Portrait of a myristoyl switch protein.
Myristoylated proteins transduce a diverse range of cellular signals. Recoverin is a myristoylated, calcium-binding protein in the retina that serves as a calcium sensor in vision. The recent elucidation of the structures of several forms of myristoylated and unmyristoylated recoverin provides insight into how calcium induces the binding of recoverin to membranes.
Ames
J B
JB
Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305, USA.
Tanaka
T
T
Stryer
L
L
Ikura
M
M
D000595:Amino Acid Sequence; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000737:chemistry*; D005136:Eye Proteins; D051597:Hippocalcin; D008074:Lipoproteins; D008969:Molecular Sequence Data; D019814:Myristic Acid; D009227:Myristic Acids / Q000737:chemistry*; D009419:Nerve Tissue Proteins; D011487:Protein Conformation; D051603:Recoverin; D015398:Signal Transduction / Q000502:physiology*
D002135:Calcium-Binding Proteins; D005136:Eye Proteins; D008074:Lipoproteins; D009227:Myristic Acids; D009419:Nerve Tissue Proteins; D019814:Myristic Acid; D051603:Recoverin; D051597:Hippocalcin; D002118:Calcium