title: Span of apprehension deficits in older outpatients with schizophrenia.
abstract: Performance on the span of apprehension task, a well-studied information processing task in schizophrenia research, was examined in 11 schizophrenia patients and 11 normal comparison participants, all over the age of 45 years. Subjects detected "T' and "F' targets in briefly-flashed arrays of 1, 6, and 12 letters on the span task. Consistent with previously reported findings in younger schizophrenia patients, the older patients detected significantly fewer targets in the larger (12-letter), but not smaller (1-, or 6-letter), arrays. The older schizophrenia patients also showed significantly slower reaction times in all array-size conditions. Neither age of onset nor duration of illness was significantly correlated with span task performance. The characteristic span of apprehension task deficit found in the older schizophrenia patients suggests that late-life schizophrenia shares a common cognitive impairment with childhood and young adulthood schizophrenia, and provides supportive evidence for a possible stable vulnerability trait deficit in schizophrenia that is independent of age of onset and duration of illness.
authors.affiliation: Department of Psychiatry, University of California, San Diego, USA. egranholm@ucsd.edu
authors.forename: E
authors.initials: E
authors.lastname: Granholm
authors.forename: R F
authors.initials: RF
authors.lastname: Asarnow
authors.forename: S P
authors.initials: SP
authors.lastname: Verney
authors.forename: P
authors.initials: P
authors.lastname: Nelson
authors.forename: D V
authors.initials: DV
authors.lastname: Jeste
mesh_terms: D000367:Age Factors; D000368:Aged; D001288:Attention; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual; D011569:Psychiatric Status Rating Scales; D011930:Reaction Time; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis*; D012565:Schizophrenic Psychology