Serum haptoglobin concentration in growing swine after intranasal challenge with Bordetella bronchiseptica and toxigenic Pasteurella multocida type D.
The acute phase reaction, in association with progressive atrophic rhinitis (AR), was monitored for 3 wk using serum haptoglobin (HPT) quantification in thirty-six, 15 kg swine after intranasal challenge with varying doses of Pasteurella multocida type D (toxigenic strain) and Bordetella bronchiseptica. The challenge doses were administered alone or in combination with pigs divided into 9 isolated treatment groups. Increasing doses of B. bronchiseptica were associated with lower serum HPT (P < 0.05), whereas increasing doses of P. multocida tended to increase serum HPT (0.05 < P < 0.10). Significant and positive correlation of mean HPT and AR score was found in these pigs; increased AR scores were associated with elevated mean HPT concentration (r = 0.41, P < 0.01). A significant interaction between P. multocida and B. bronchiseptica dose indicated that increasing the dose of B. bronchiseptica, for a fixed P. multocida dose, was associated with less AR (P < 0.05). The AR scores were greater in pigs given P. multocida, than B. bronchiseptica alone. These results indicate that a complex interaction between Pasteurella multocida and Bordetella bronchiseptica causes progressive atrophic rhinitis and alters serum HPT concentration in swine.
Francisco
C J
CJ
Department of Veterinary Clinical medicine, College of Veterinary Medicine, University of Illinois, Urbana 61801, USA.
Shryock
T R
TR
Bane
D P
DP
Unverzagt
L
L
D000281:Administration, Intranasal; D000818:Animals; D001885:Bordetella Infections / Q000097:blood / Q000150:complications / Q000662:veterinary*; D016950:Bordetella bronchiseptica / Q000502:physiology*; D005260:Female; D006242:Haptoglobins / Q000032:analysis*; D010326:Pasteurella Infections / Q000097:blood / Q000150:complications / Q000662:veterinary*; D016979:Pasteurella multocida / Q000502:physiology*; D012222:Rhinitis, Atrophic / Q000209:etiology / Q000382:microbiology / Q000662:veterinary; D013552:Swine / Q000097:blood* / Q000254:growth & development*; D013553:Swine Diseases / Q000097:blood*
D006242:Haptoglobins