Chromosomal mapping of cell death proteases CPP32, MCH2, and MCH3.
Apoptosis may involve a specialized proteolytic cascade catalyzed by interleukin-1beta-converting enzyme-like proteases. We have recently identified three new members of this family (CPP32, MCH2, MCH3) and shown that they play an important role in promoting cell death. Here we report the chromosomal mapping of CPP32 to 4q34, MCH2 to 4q25, and MCH3 to 10q25.
Bullrich
F
F
Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107, USA.
Fernandes-Alnemri
T
T
Litwack
G
G
Alnemri
E S
ES
Croce
C M
CM
D000818:Animals; D017209:Apoptosis; D020170:Caspase 1; D053148:Caspase 3; D020169:Caspases; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D002894:Chromosomes, Human, Pair 4; D003546:Cysteine Endopeptidases / Q000235:genetics*; D006801:Humans; D012377:Rodentia
C505407:CASP3 protein, human; D053148:Caspase 3; D020169:Caspases; D003546:Cysteine Endopeptidases; D020170:Caspase 1