Long-term behavioural effects of TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline) after subchronic treatment in rats.
1-Trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo), which shows a great structural similarity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), when administered to rats lead to enhanced spontaneous locomotion when they were tested 4-9 days after subchronic injection at a daily dose of 0.2 mg/kg over a seven week period. However, 9 weeks after the end of the course of injections animals walked more slowly during 12 hours of nocturnal activity, and apomorphine-induced locomotion was decreased 12 weeks later. These results suggest that the drug may exert a progressive neurotoxic effect.
Sontag
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KH
Max-Planck-Institute for Experimental Medicine, Göttingen, Federal Republic of Germany.
Heim
C
C
Sontag
T A
TA
God
R
R
Reichmann
H
H
Wesemann
W
W
Rausch
W D
WD
Riederer
P
P
Bringmann
G
G
D000704:Analysis of Variance; D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors*; D002243:Carbolines / Q000008:administration & dosage / Q000633:toxicity*; D004334:Drug Administration Schedule; D005260:Female; D009043:Motor Activity / Q000187:drug effects*; D009498:Neurotoxins / Q000008:administration & dosage / Q000633:toxicity*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000523:psychology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D002243:Carbolines; D009498:Neurotoxins; C067372:1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline; D001058:Apomorphine