title: Molecular mechanisms of NaCl cotransport.
abstract: Electroneutral Na-(K)-Cl cotransporters are present in most cell types, where they play an important role in both sodium-chloride absorption and secretion and cell volume regulation. Recent advances in the molecular identification of these cotransporters have provided a new level of insight into the mechanisms of sodium-chloride-coupled cotransport and its regulation. Here we review what is known about the Na-(K)-Cl cotransporters cloned to date and what can be deduced about their structure and function and summarize recent physiological investigations of the regulation of Na-(K)-Cl cotransport. These studies represent the beginning of an exciting and rapidly expanding field examining the molecular mechanisms of sodium-chloride-coupled cotransport.
authors.affiliation: Department of Medicine, Brigham & Women's Hospital, Massachusetts 02115, USA.
authors.forename: M R
authors.initials: MR
authors.lastname: Kaplan
authors.forename: D B
authors.initials: DB
authors.lastname: Mount
authors.forename: E
authors.initials: E
authors.lastname: Delpire
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000096:biosynthesis / Q000378:metabolism* / Q000502:physiology; D002712:Chlorides / Q000378:metabolism; D006801:Humans; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D028021:Sodium-Potassium-Chloride Symporters
chemical_list: D002352:Carrier Proteins; D002712:Chlorides; D028021:Sodium-Potassium-Chloride Symporters; D012964:Sodium; D011188:Potassium