title: No significant effect of age of onset on response to anti-asthmatic medications in adult asthmatics.
abstract: In order to know the effect of age of onset on response to antiasthmatic medications in adult asthmatics, the changes in bronchial hyper-responsiveness and symptoms were retrospectively assessed following four to five month-treatments in patients with a less than two-year history of asthma. There was no significant difference in regimens among the three groups. The histamine PC20 value increased significantly from 456 to 1015 micrograms/ml in group A (20-39 yrs), 531 to 2363 micrograms/ml in group B (40-59 yrs), and 256 to 1148 micrograms/ml in group C (60 < or =) following the administration of the agents for four to five months. The percentage of patients who became symptom-free also increased significantly in each group along with a decrease in the bronchial hyper-responsiveness. There was no significant difference in the degrees of improvement in bronchial hyper-responsiveness and symptoms. These results suggest that the age of onset of asthma may not be related to the response to anti-asthmatic medications in adult asthmatics.
authors.affiliation: First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Oosaki
authors.forename: Y
authors.initials: Y
authors.lastname: Mizushima
authors.forename: A
authors.initials: A
authors.lastname: Kawasaki
authors.forename: T
authors.initials: T
authors.lastname: Kashii
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D001249:Asthma / Q000188:drug therapy*; D001507:Beclomethasone / Q000627:therapeutic use*; D016535:Bronchial Hyperreactivity / Q000188:drug therapy; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D001993:Bronchodilator Agents; D001507:Beclomethasone