Effects of the adjuvant MPL + TDM on tumor challenge in the B16 mouse melanoma model.
Mice were injected three times at 2 week intervals with the adjuvant MPL + TDM or phosphate-buffered saline. Two weeks after the last injection, all mice were challenged subcutaneously with a tumorgenic dose of B16 tumor and observed for 40 days. The adjuvant hastened the time at which tumors appeared (P = 0.02).
Price
J A
JA
Department of Biochemistry and Microbiology, College of Osteopathic Medicine, Oklahoma State University, Tulsa 74107, USA.
McGee
J M
JM
Patten
M R
MR
Snyder
D
D
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D003311:Cord Factors / Q000494:pharmacology*; D008050:Lipid A / Q000031:analogs & derivatives* / Q000494:pharmacology; D008546:Melanoma, Experimental / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D014407:Tumor Cells, Cultured
D000276:Adjuvants, Immunologic; D003311:Cord Factors; D008050:Lipid A; C043399:6,6'-dicorynomycolyl trehalose; C048436:monophosphoryl lipid A