Cyclooxygenase-independent mechanisms are not involved in the antipyretic action of indomethacin in the prepubertal pig.
The effects of an intravenous, antipyretic dose of indomethacin (IND) on basal and prostaglandin E2 (PGE2)-induced changes in body temperature were investigated in an attempt to assess whether noncyclooxygenase pathways contribute to the pharmacological actions of IND in swine. The results showed that IND lowered basal temperature for about 90 min but failed to modify the febrile effects of PGE2. These findings suggest that IND acts only as an antagonist of constitutive and inducible cyclooxygenase in this species. Neuroanatomical and sex-steroid dependent mechanisms are discussed as explanations for the apparently different actions of IND in rodents and ungulates.
Parrott
R F
RF
MAFF Welfare and Behaviour Laboratory, Department of Neurobiology, Babraham Institute, Cambridge, UK.
Vellucci
S V
SV
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D015232:Dinoprostone / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D011451:Prostaglandin-Endoperoxide Synthases / Q000502:physiology*; D013552:Swine
D018712:Analgesics, Non-Narcotic; D011451:Prostaglandin-Endoperoxide Synthases; D015232:Dinoprostone; D007213:Indomethacin