Familial risks of squamous cell carcinoma of the head and neck: retrospective case-control study.
OBJECTIVE
To determine the contribution of inheritance to the incidence of squamous cell carcinoma of the head and neck.


METHODS
Historical cohort study. First degree relatives of cases with squamous cell carcinoma of the head and neck made up the exposed cohort and first degree relatives of spouses of cases made up the comparison unexposed cohort.


METHODS
Ear, nose, and throat clinic in a large metropolitan teaching hospital.


METHODS
1429 first degree relatives of 242 index cases of squamous cell carcinoma of the head and neck; as controls, 934 first degree relatives of the spouses of 156 index cases.


METHODS
Relative risk of developing squamous cell carcinoma in first degree relatives of cases compared with risk in first degree relatives of spouses.


RESULTS
The adjusted relative risk for developing head and neck cancer if the index case had squamous cell carcinoma of the head and neck was 3.79 (95% confidence interval 1.11 to 13.0). There were no significantly increased risks associated with a family history of cancer at other sites. The adjusted relative risk for squamous cell carcinoma of the head and neck was 7.89 (1.50 to 41.6) in first degree relatives of patients with multiple primary head and neck tumours.


CONCLUSIONS
These data suggest that genetic factors are important in the aetiology of head and neck cancer, in particular for patients with multiple primary cancers. Given the prolonged exposure of these subjects to carcinogens, these genetic factors may have a role in modifying carcinogen activity or in host resistance to carcinogens. Inherited factors may be important in persons with environmentally induced cancers.
Foulkes
W D
WD
Department of Medicine, Montreal General Hospital, McGill University, Canada. MDWF@musica.mcgill.ca
Brunet
J S
JS
Sieh
W
W
Black
M J
MJ
Shenouda
G
G
Narod
S A
SA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics; D010375:Pedigree; D011792:Quebec; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking