Effect of haloperidol on the behavioral stimulation by N-cyanomethylmethamphetamine, a main product of smoking methamphetamine mixed with tobacco.
N-Cyanomethylmethamphetamine is a main product of smoking methamphetamine mixed with tobacco. The aim of this experiment was to evaluate the effects of haloperidol on behavioral stimulation by N-cyanomethylmethamphetamine (3 mg/kg s.c.) in terms of ambulation in mice. Repeated administration of N-cyanomethylmethamphetamine, carried out 5 x at 3-day intervals, induced a sensitization to its ambulation-increasing effect. Haloperidol (0.01, 0.03, 0.1 and 0.3 mg/kg s.c.) significantly inhibited not only the acute stimulant effect of N-cyanomethylmethamphetamine but also the induction of sensitization. The dose-effect curves for the inhibitory effects of haloperidol on the N-cyanomethylmethamphetamine-induced ambulatory stimulation were almost the same between the drug-native and N-cyanomethylmethamphetamine-sensitized mice. Moreover, such behavioral characteristics of N-cyanomethylmethamphetamine; the behavioral stimulant effect, the induction of sensitization following repeated administration, and the inhibition of its effects by haloperidol, were qualitatively the same as those of methamphetamine (2 mg/kg s.c.). These results suggest that N-cyanomethylmethamphetamine possesses methamphetamine-like central stimulant effect and that D2 dopaminergic mechanisms are involved in the effect of N-cyanomethylmethamphetamine.
Kuribara
H
H
Department of Neurobiology and Behavior, Gunma University School of Medicine, Japan.
Sekine
H
H
Nakahara
Y
Y
D000662:Amphetamines / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*; D012907:Smoking / Q000503:physiopathology*
D000662:Amphetamines; D014150:Antipsychotic Agents; D000697:Central Nervous System Stimulants; D018492:Dopamine Antagonists; C094439:N-cyanomethylmethamphetamine; D008694:Methamphetamine; D006220:Haloperidol