Platelet PGI2 receptor affinity is reduced in pre-eclampsia.
Prostacyclin (PGI2) receptors were studied in platelet membrane preparations from women with normal pregnancy, pregnancy-induced hypertension (PIH) or pre-eclampsia. Patient groups showed no differences in gestational week at delivery. A markedly lower birth weight, however, was found in pre-eclampsia. No differences between groups could be detected in platelet PGI2 receptor number. In contrast, the binding affinity to the PGI2 mimetic iloprost was considerably reduced in pre-eclampsia, whereas receptor affinity between PIH and normal pregnancy did not differ significantly.
Klockenbusch
W
W
Institut für Pharmakologie, Heinrich-Heine-Universität Düsseldorf, Germany.
Hohlfeld
T
T
Wilhelm
M
M
Somville
T
T
Schrör
K
K
D000328:Adult; D001724:Birth Weight; D001792:Blood Platelets / Q000378:metabolism*; D011464:Epoprostenol / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology; D016285:Iloprost / Q000097:blood; D007231:Infant, Newborn; D011225:Pre-Eclampsia / Q000097:blood* / Q000503:physiopathology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood / Q000503:physiopathology; D011485:Protein Binding; D044006:Receptors, Epoprostenol; D011982:Receptors, Prostaglandin / Q000097:blood*
D044006:Receptors, Epoprostenol; D011982:Receptors, Prostaglandin; D011464:Epoprostenol; D016285:Iloprost