Donor-to-donor and donor-to-patient transmission of hepatitis C virus.
A patient was reported with suspected acute post-transfusion hepatitis C virus (HCV) infection, 5 months after the transfusion of 2 units of red cells. The archived serum samples of the two implicated donations were retested by the original 3rd-generation assay together with another 3rd-generation assay and RI-BA III, and were tested for HCV RNA using the PCR. Both donations were anti-HCV negative but one was found to be PCR positive. This donor was a regular donor and was identified as the husband of a donor identified 18 months earlier as being HCV positive. This case is an example of transmission of HCV in the window period of infection, and a probable example of the transmission of HCV from wife to husband through intimate contact.
Kitchen
A D
AD
Department of Microbiology, Brentwood Transfusion Centre, UK.
Wallis
P A
PA
Gorman
A M
AM
D001782:Blood Donors; D005260:Female; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology; D006526:Hepatitis C / Q000276:immunology / Q000517:prevention & control / Q000635:transmission*; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood; D065227:Transfusion Reaction
D018937:Hepatitis C Antibodies; D012367:RNA, Viral