title: A transcription map of the major histocompatibility complex (MHC) class I region.
abstract: We have applied cDNA hybridization selection to nine YACs spanning 3 Mb of genomic DNA from a region centromeric to HLA-A to the histone cluster that lies telomeric to the human major histocompatibility complex (MHC). In addition to Class I genes and pseudogenes, we describe over 63 genes and 23 additional expressed sequence tags distributed throughout the region. Many of the full-length genes belong to gene families. Prominent among these are a group of genes encoding proteins showing homology to the carboxyl-terminal sequences of butyrophilin and an additional group of zinc finger genes. We also detected several previously undefined genes that are specifically expressed in cells of the immune system, indicating a more complex role of the MHC in the immune response than has been appreciated.
authors.affiliation: Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, 06520, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Gruen
authors.forename: S R
authors.initials: SR
authors.lastname: Nalabolu
authors.forename: T W
authors.initials: TW
authors.lastname: Chu
authors.forename: C
authors.initials: C
authors.lastname: Bowlus
authors.forename: W F
authors.initials: WF
authors.lastname: Fan
authors.forename: V L
authors.initials: VL
authors.lastname: Goei
authors.forename: H
authors.initials: H
authors.lastname: Wei
authors.forename: R
authors.initials: R
authors.lastname: Sivakamasundari
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: H X
authors.initials: HX
authors.lastname: Xu
authors.forename: S
authors.initials: S
authors.lastname: Parimoo
authors.forename: G
authors.initials: G
authors.lastname: Nallur
authors.forename: R
authors.initials: R
authors.lastname: Ajioka
authors.forename: H
authors.initials: H
authors.lastname: Shukla
authors.forename: P
authors.initials: P
authors.lastname: Bray-Ward
authors.forename: J
authors.initials: J
authors.lastname: Pan
authors.forename: S M
authors.initials: SM
authors.lastname: Weissman
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002874:Chromosome Mapping / Q000379:methods*; D018244:Chromosomes, Artificial, Yeast / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics*; D019143:Evolution, Molecular; D015870:Gene Expression; D005805:Genes, MHC Class I / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics; D011544:Pseudogenes / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D014158:Transcription, Genetic; D016335:Zinc Fingers
chemical_list: D018076:DNA, Complementary; D012333:RNA, Messenger