Indomethacin loaded chitosan microspheres. Correlation between the erosion process and release kinetics.
The preparation of chitosan microspheres covalently linked with citric acid and loaded with indomethacin is described. The release kinetics correlated with the concentration of chitosan in the microsphere preparative mixture and the pH of the release medium. Deviations from Fickian to zero order kinetics were observed at higher concentrations of chitosan and at pH 7.4. The variations induced by these parameters on drug diffusion and solubility in the matrix undergoing erosion were analyzed.
Orienti
I
I
Aiedeh
K
K
Gianasi
E
E
Bertasi
V
V
Zecchi
V
V
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry; D002021:Buffers; D002614:Chelating Agents / Q000737:chemistry; D002686:Chitin / Q000031:analogs & derivatives; D048271:Chitosan; D019343:Citric Acid / Q000737:chemistry; D003432:Cross-Linking Reagents; D004058:Diffusion; D007213:Indomethacin / Q000008:administration & dosage* / Q000737:chemistry; D007700:Kinetics; D008863:Microspheres; D008970:Molecular Weight; D012995:Solubility; D014783:Viscosity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002021:Buffers; D002614:Chelating Agents; D003432:Cross-Linking Reagents; D002686:Chitin; D019343:Citric Acid; D048271:Chitosan; D007213:Indomethacin