title: [Clinical significance of the determination of protein C dependent disorders of hemostasis in surgical patients].
abstract: Diagnostic value of protein C measurements was investigated in 159 surgical patients with diseases of the liver, great vessels, and wound infection. Protein C antigen was detected by ELISA with specific antibodies to protein C. The changes of protein C antigenic activity correlated with severity of hepatic disorders. Inhibition of protein C synthetic activity went on in parallel with a fall in pseudocholine esterase concentrations. This suggests feasibility of protein C measurements for examination of protein production by the liver. Characteristics and location of the lesions in great vessels were also related to protein C antigen levels. The fall in this antigen quantity was observed in patients with purulent wound infection. The greater the fall, the more serious the patient's condition became.
authors.forename: A A
authors.initials: AA
authors.lastname: Karelin
authors.forename: A A
authors.initials: AA
authors.lastname: Adamian
authors.forename: M I
authors.initials: MI
authors.lastname: Titova
authors.forename: V V
authors.initials: VV
authors.lastname: Egorova
mesh_terms: D001778:Blood Coagulation Disorders / Q000175:diagnosis / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000601:surgery; D008107:Liver Diseases / Q000175:diagnosis / Q000601:surgery; D011379:Prognosis; D011486:Protein C / Q000032:analysis* / Q000276:immunology; D013514:Surgical Procedures, Operative; D013530:Surgical Wound Infection / Q000175:diagnosis; D014652:Vascular Diseases / Q000175:diagnosis / Q000601:surgery
chemical_list: D011486:Protein C