title: Larvicidal constituents of Melantheria albinervia.
abstract: Bioactivity-guided fractionation has led to the isolation of two larvicidal diterpenes, active against the yellow fever-transmitting mosquito Aedes aegypti, from a dichloromethane root extract of Melantheria albinervia (Asteraceae), a plant from Zimbabwe. These diterpenes were identified as ent-kaur-16-en-19-oic acid and 9(11),16-kauradien-19-oic acid. The diterpenes were also weakly active against Bacillus subtilis.
authors.affiliation: Institut de Pharmacognosie et Phytochimie, Université de Lausanne, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Slimestad
authors.forename: A
authors.initials: A
authors.lastname: Marston
authors.forename: S
authors.initials: S
authors.lastname: Mavi
authors.forename: K
authors.initials: K
authors.lastname: Hostettmann
mesh_terms: D000330:Aedes / Q000187:drug effects* / Q000196:embryology / Q000821:virology; D000818:Animals; D004224:Diterpenes / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects*; D009032:Mosquito Control; D010944:Plants / Q000737:chemistry*
chemical_list: C101982:9(11),16-kauradien-19-oic acid; D004224:Diterpenes; C014341:argyrophilic acid