title: Thymosin alpha 1 protects liver and aorta from oxidative damage in atherosclerotic rabbits.
abstract: The thymus hormones were reported to be effective on lipid peroxidation and the antioxidant system. Thymus plays a broader role than just regulating the immune system. Thymosin alpha 1 is the first subgroup extracted from thymosin F5 and has higher biological activity than thymosin F5. In the present study, we have examined the effects of thymosin alpha 1 on lipid levels and lipid peroxidation and glutathione (GSH) content in the plasma, liver and aorta tissues of atherosclerotic rabbits. At the end of thymosin alpha 1 treatment, we determined the lipid levels and lipid peroxidation of the plasma, liver and aorta tissues and hepatic subcellular fractions in these rabbits. Our results demonstrated that thymosin alpha 1 might normalize changed lipid levels and increased lipid peroxides and also elevate decreased GSH in the plasma, liver and aorta tissues of atherosclerotic rabbits. Results of this study suggest that thymosin alpha 1 may be beneficial to prevent and/or to treat atherosclerosis.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Istanbul, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Gökkusu
authors.forename: E
authors.initials: E
authors.lastname: Ademoğlu
authors.forename: U M
authors.initials: UM
authors.lastname: Türkoğlu
authors.forename: H
authors.initials: H
authors.lastname: Oz
authors.forename: F
authors.initials: F
authors.lastname: Oz
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001011:Aorta / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D001161:Arteriosclerosis / Q000378:metabolism* / Q000473:pathology; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress; D011817:Rabbits; D000077596:Thymalfasin; D013947:Thymosin / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D002791:Cholesterol, Dietary; D008315:Malondialdehyde; D013947:Thymosin; D000077596:Thymalfasin