title: Results of resection of T3 non-small cell lung cancer invading the mediastinum or main bronchus.
abstract: BACKGROUND
  T3 tumors can be divided into several subgroups. Surgical treatment of T3 tumors with chest wall invasion results in good survival. This study shows the results of resection of T3 non-small cell tumors located in the main bronchus or with invasion of mediastinal structures.
  
  
  METHODS
  From 1977 through 1993, 108 patients underwent resection for primary non-small cell carcinomas located in the main bronchus or with invasion of mediastinal structures. A complete resection was performed in 70 patients (64.8%). Actuarial survival time was estimated and risk factors for late death were identified.
  
  
  RESULTS
  Overall hospital mortality was 8.3%. All deaths followed pneumonectomy. Mean 5-year survival was 29% for all hospital survivors, 35% for patients with complete resection, and 18% for patients with incomplete resection (p = 0.03). In patients with complete resection, mean 5-year survival was 45% for N0 patients and 37% for N1 patients. There were no 5-year survivors in the group of N2 patients. The mean 5-year survival was greater (but not statistically significantly greater) in patients with tumors located in the main bronchus (40%) than in patients with tumors with invasion of mediastinal structures (25%) (p > 0.05). Histology, tumor spill, age, sex, and type of operative procedure were not significant prognostic factors.
  
  
  CONCLUSIONS
  Patients with tumors located in the main bronchus have a better survival than patients with invasion of the mediastinal structures. Pneumonectomy increases hospital mortality. Incompleteness of resection and mediastinal lymph node involvement influence survival significantly.
authors.affiliation: Department of Pulmonology, Sint Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: C C
authors.initials: CC
authors.lastname: Pitz
authors.forename: A
authors.initials: A
authors.lastname: Brutel de la Rivière
authors.forename: H R
authors.initials: HR
authors.lastname: Elbers
authors.forename: C J
authors.initials: CJ
authors.lastname: Westermann
authors.forename: J M
authors.initials: JM
authors.lastname: van den Bosch
mesh_terms: D000328:Adult; D000368:Aged; D001980:Bronchi / Q000473:pathology*; D002283:Carcinoma, Bronchogenic / Q000401:mortality / Q000473:pathology / Q000601:surgery; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D008482:Mediastinum / Q000473:pathology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011013:Pneumonectomy; D012189:Retrospective Studies; D015996:Survival Rate