title: Transmembrane Ca2+ gradient and function of membrane proteins.
abstract: This review will focus on the recent advance in the study of effect of transmembrane Ca2+ gradient on the function of membrane proteins. It consits of two parts: 1. Transmembrane Ca2+ gradient and sarcoplasmic reticulum Ca(2+)-ATPase; 2. Effect of transmembrane Ca2+ gradient on the components and coupling of cAMP signal transduction pathway. The results obtained indicate that a proper transmembrane Ca2+ gradient may play an important role in modulating the conformation and activity of SR Ca(2+)-ATPase and the function of membrane proteins involved in the cAMP signal transduction by mediating the physical state change of the membrane phospholipids.
authors.affiliation: National Laboratory of Biomacromolecules, Institute of Biophysics, Beijing, China.
authors.forename: F Y
authors.initials: FY
authors.lastname: Yang
authors.forename: Y G
authors.initials: YG
authors.lastname: Huang
authors.forename: Y P
authors.initials: YP
authors.lastname: Tu
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D006801:Humans; D017136:Ion Transport; D008565:Membrane Proteins / Q000378:metabolism*; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D008565:Membrane Proteins; D000252:Calcium-Transporting ATPases; D002118:Calcium