alpha 2A/D-Adrenoceptor subtype predominates also in the neonatal rat spinal cord.
alpha 2-Adrenoceptors are remarkably regulated by developmental factors. In this study alpha 2-adrenoceptor subtypes have been characterised in neonatal and adult rat spinal cords. In saturation experiments, a 5% proportion of [3H]rauwolscine binding has a high affinity component, representing the alpha 2C-subtype in both tissues. Competition studies with [3H]RX821002 indicate that in both tissues the alpha 2A/D subtype is expressed similarly.
Savola
M K
MK
Department of Pharmacology, University of Turku, Finland.
Savola
J M
JM
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D005260:Female; D019329:Idazoxan / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D018341:Receptors, Adrenergic, alpha-2 / Q000032:analysis*; D013116:Spinal Cord / Q000737:chemistry*; D014316:Tritium; D015016:Yohimbine / Q000494:pharmacology
D000316:Adrenergic alpha-Agonists; D018341:Receptors, Adrenergic, alpha-2; D014316:Tritium; D015016:Yohimbine; C058525:2-methoxyidazoxan; D019329:Idazoxan