Human enzyme polymorphism in the Canary Islands. VII. G6PD Seattle in Canarians and North African Berbers.
Sequence analysis of the glucose-6-phosphate dehydrogenase (G6PD) variant Gc, characterized by slower electrophoretic mobility than G6PD-B, in 14 Canarian and 2 Berber males, has revealed that all of them share the G-->C mutation at nucleotide 844 in exon 8 leading to an Asp-->His substitution at amino acid 282 known as G6PD Seattle. No additional differences have been detected among them nor with the common haplotype previously found for this variant.
Cabrera
V M
VM
Department of Genetics, University of La Laguna, Tenerife, Spain.
González
P
P
Salo
W L
WL
D000352:Africa, Northern; D000483:Alleles; D001266:Atlantic Islands; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D005820:Genetic Testing; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA
D005954:Glucosephosphate Dehydrogenase