title: Myosin and kinesin: mother and child reunited.
abstract: The recent solution of the crystal structure of the kinesin motor domain reveals striking similarities to the core region of the myosin motor domain, implying a strong evolutionary relationship between these two motors. However, a complete understanding of the way that motility is generated will require additional structural information, which may explain how the two motors have adapted to their fundamentally different linear substrates, F-actin and microtubules.
authors.affiliation: Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15214, USA.
authors.forename: D D
authors.initials: DD
authors.lastname: Hackney
mesh_terms: D000818:Animals; D016547:Kinesins / Q000737:chemistry* / Q000502:physiology / Q000648:ultrastructure; D008854:Microscopy, Electron; D008870:Microtubules / Q000502:physiology; D008958:Models, Molecular; D015394:Molecular Structure; D009068:Movement / Q000502:physiology; D009119:Muscle Contraction / Q000502:physiology; D009218:Myosins / Q000737:chemistry* / Q000502:physiology / Q000648:ultrastructure; D011487:Protein Conformation
chemical_list: D009218:Myosins; D016547:Kinesins