Effect of iodixanol on in vitro bleeding time.
OBJECTIVE
Both monomeric and dimeric ionic radio contrast media (CM) have been shown to be more anticoagulant than nonionic monomeric CM. Iodixanol is a relatively new nonionic dimeric contrast medium. We investigated whether the dimeric structure of iodixanol would produce the same level of anticoagulation that has been observed using nonionic monomeric CM.


METHODS
We used a global screening device that operates under physiologic flow conditions to monitor the effects of iodixanol on in vitro bleeding time (IVBT). This flow dynamic technique perfuses nonanticoagulated whole blood through a hollow fiber device. A leak in the fiber is created by a precision needle, and the resulting pressure fluctuations within the fiber are monitored to examine the ability of the hemostatic system to close the leak by forming a stable platelet plug.


RESULTS
In 20 donors, iodixanol (25% CM/blood, v/v) was shown to lengthen the mean IVBT (18.74 min) compared with the normal blood mean IVBT (4.24 min).


CONCLUSIONS
The addition of dimeric iodixanol to normal blood affects the IVBT in the same manner as nonionic monomeric CM (ioversol, iopamidol, and iohexol).
Melton
L G
LG
Department of Medicine, University of North Carolina School of Medicine, Chapel Hill 27599, USA.
Muga
K M
KM
Gabriel
D A
DA
D000925:Anticoagulants / Q000494:pharmacology; D001760:Bleeding Time; D001777:Blood Coagulation / Q000187:drug effects*; D003287:Contrast Media; D006801:Humans; D066298:In Vitro Techniques; D014283:Triiodobenzoic Acids / Q000494:pharmacology*
D000925:Anticoagulants; D003287:Contrast Media; D014283:Triiodobenzoic Acids; C044834:iodixanol