title: Generating 'tiger' as an animal name or a word beginning with T: differences in brain activation.
abstract: Positron emission tomography was used to investigate differences in regional cerebral activity during word retrieval in response to different prompts. The contrast of semantic category fluency and initial letter fluency resulted in selective activation of left temporal regions; the reverse contrast yielded activation in left frontal regions (BA44/6). A further comparison between types of category fluency demonstrated a more anterior temporal response for natural kinds and more posterior activation for manipulable manmade objects. These results support behavioural data suggesting that category fluency is relatively more dependent on temporal-lobe regions, and initial letter fluency on frontal structures; and that categorical word retrieval is not a uniformly distributed function within the brain. This is compatible with the category-specific deficits observed after some focal lesions.
authors.affiliation: Wellcome Department of Cognitive Neurology, Institute of Neurology, London, U.K.
authors.forename: C J
authors.initials: CJ
authors.lastname: Mummery
authors.forename: K
authors.initials: K
authors.lastname: Patterson
authors.forename: J R
authors.initials: JR
authors.lastname: Hodges
authors.forename: R J
authors.initials: RJ
authors.lastname: Wise
mesh_terms: D000328:Adult; D001288:Attention; D003463:Cues; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000502:physiology*; D006801:Humans; D007807:Language Tests; D008297:Male; D008606:Mental Processes; D011939:Mental Recall; D008875:Middle Aged; D011859:Radiography; D014055:Tomography, Emission-Computed