Anti-inflammatory activity of flavonol glycosides from Erythrospermum monticolum depending on single or repeated local TPA administration.
Two anti-inflammatory principles were isolated from the methanol extract of the leaves of Erythrospermum monticolum (Flacourtiaceae). The isolation was based on a guided bioassay of the inhibitory activity on TPA-induced ear edema in mice. These compounds were identified as quercetin 3-O-xylosyl(1-->2) rhamnoside and quercetin 3-O-rhamnoside. In addition, their effects on a chronic topic inflammation model were evaluated.
del Carmen Recio
M
M
Departament de Farmacologia, Universitat de València, Spain.
Giner
R M
RM
Máñez
S
S
Talens
A
A
Cubells
L
L
Gueho
J
J
Julien
H R
HR
Hostettmann
K
K
Rios
J L
JL
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004187:Disaccharides / Q000737:chemistry / Q000627:therapeutic use*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D051379:Mice; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D013755:Tetradecanoylphorbol Acetate / Q000008:administration & dosage / Q000633:toxicity*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004187:Disaccharides; C101971:quercetin 3-O-xylosyl-1-2-rhamnoside; C012526:quercitrin; D011794:Quercetin; D013755:Tetradecanoylphorbol Acetate