title: DLG1: chromosome location of the closest human homologue of the Drosophila discs large tumor suppressor gene.
abstract: The Drosophila discs large tumor suppressor protein, Dlg, is the prototype of a newly discovered family of proteins termed MAGUKs (membrane-associated guanylate kinase homologues). MAGUKs are localized at the membrane-cytoskeleton interface, usually at cell-cell junctions, where they appear to have both structural and signaling roles. They contain several distinct domains, including a modified guanylate kinase domain, an SH3 motif, and one or three copies of the DHR (GLGF/PDZ) domain. Recessive lethal mutations in the discs large tumor suppressor gene interfere with the formation of septate junctions (thought to be the arthropod equivalent of tight junctions) between epithelial cells, and they cause neoplastic overgrowth of imaginal discs, suggesting a role for cell junctions in proliferation control. A homologue of the Dlg protein, named Hdlg, has been isolated from human B lymphocytes. It shows 65-79% identity to Dlg in the different domains, and it binds to the cytoskeletal protein 4.1. Here, we report that the gene for lymphocyte Hdlg, named DLG1, is located at chromosome band 3q29. This finding identifies a novel site for a candidate tumor suppressor on chromosome 3.
authors.affiliation: Department of Biomedical Research, Tufts University School of Medicine, Boston, Massachusetts 02135, USA.
authors.forename: A C
authors.initials: AC
authors.lastname: Azim
authors.forename: J H
authors.initials: JH
authors.lastname: Knoll
authors.forename: S M
authors.initials: SM
authors.lastname: Marfatia
authors.forename: D J
authors.initials: DJ
authors.lastname: Peel
authors.forename: P J
authors.initials: PJ
authors.lastname: Bryant
authors.forename: A H
authors.initials: AH
authors.lastname: Chishti
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D017931:DNA Primers; D000074288:Discs Large Homolog 1 Protein; D004330:Drosophila / Q000235:genetics; D029721:Drosophila Proteins; D016147:Genes, Tumor Suppressor; D006801:Humans; D006822:Hybrid Cells; D007301:Insect Hormones / Q000235:genetics*; D008565:Membrane Proteins; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics*; D012377:Rodentia; D025521:Tumor Suppressor Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C513314:DLG1 protein, human; D017931:DNA Primers; D000074288:Discs Large Homolog 1 Protein; D029721:Drosophila Proteins; D007301:Insect Hormones; D008565:Membrane Proteins; D011506:Proteins; D025521:Tumor Suppressor Proteins; C070350:dlg1 protein, Drosophila