Distribution of lead in lactating mice and suckling offspring with special emphasis on the mammary gland.
The distribution of lead in lactating mice and suckling offspring was studied with whole body autoradiography at 4 and 24 h after a single intravenous injection of 203Pb (50 nmol Pb/kg) to the dams. In the lactating mice on day 14 of lactation, the highest uptake of radioactivity at 4 h after administration was recorded in renal cortex, skeleton and liver. A high uptake was also evident in the mammary gland. At 24 h after administration, the radioactivity had decreased in most organs except in the skeleton. In the suckling pups, exposed to lead only via dams' milk for 24 h, the highest level of radioactivity was present in the intestinal mucosa and a much lower level of radioactivity was present in the skeleton. The mammary glands from mice given three daily intravenous injections of 240 mumol Pb/kg were examined with X-ray microanalysis. At 4 h after the last injection, lead was found associated with casein micelles both inside the alveolar cell and in the milk lumen, indicating that lead is excreted into the milk, bound to casein, via the Golgi secretory system.
Hallén
I P
IP
Toxicology Division, Swedish National Food Administration, Uppsala.
Norrgren
L
L
Oskarsson
A
A
D000818:Animals; D000833:Animals, Suckling; D005260:Female; D007774:Lactation / Q000187:drug effects*; D007854:Lead / Q000032:analysis*; D008321:Mammary Glands, Animal / Q000737:chemistry* / Q000648:ultrastructure; D051379:Mice; D008815:Mice, Inbred Strains; D009928:Organ Specificity
D007854:Lead