Peroxidative oxidation of lipids in slices of olfactory cortex of the rat brain during long-term potentiation.
The content of the products of the peroxidative oxidation of lipids (POL) in slices of olfactory cortex of the rat brain during long-term potentiation was investigated. The phasic character of the changes in the level of POL as a function of the duration of potentiation was demonstrated. The initial stages of potentiation (5 min) is characterized by an increase in POL; the stationary phase (15 min) is accompanied by inhibition of free-radical oxidation of lipids; the concluding phase of long-term potentiation (30 min) leads to the normalization of POL. The dynamics of the change in POL reflect the adaptive character of the development of potentiation in the slices.
Nilova
N S
NS
Laboratory of Functional Neurochemistry, I.P. Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg.
Polezhaeva
L N
LN
D000818:Animals; D005609:Free Radicals; D066298:In Vitro Techniques; D050356:Lipid Metabolism; D015227:Lipid Peroxidation / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012903:Smell / Q000502:physiology*; D013003:Somatosensory Cortex / Q000378:metabolism* / Q000502:physiology
D005609:Free Radicals