Termination of second trimester pregnancy with gemeprost and misoprostol: a randomized double-blind placebo-controlled trial.
A prospective randomized double-blind placebo-controlled trial was conducted in 70 subjects to determine whether pre-treatment with misoprostol could facilitate termination of second trimester pregnancy by gemeprost. The women received either 400 micrograms oral misoprostol or placebo tablets 12 hours before the administration of vaginal pessary of gemeprost 1 mg every 3 hours. There were no significant differences in induction-abortion interval and the amount of gemeprost required between the misoprostol and the placebo group. There was no significant difference in the incidence of side effects or analgesic requirement between the two groups. We conclude that oral misoprostol is not useful in facilitating termination of second trimester pregnancy by gemeprost.
Wong
K S
KS
Department of Obstetrics and Gynaecology, Kwong Wah Hospital, Hong Kong.
Ngai
C S
CS
Chan
K S
KS
Tang
L C
LC
Ho
P C
PC
D000028:Abortion, Induced; D000282:Administration, Intravaginal; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000527:Alprostadil / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D016595:Misoprostol / Q000008:administration & dosage* / Q000009:adverse effects; D010919:Placebos; D011247:Pregnancy; D011262:Pregnancy Trimester, Second
D010919:Placebos; D016595:Misoprostol; C021182:gemeprost; D000527:Alprostadil