Exploiting the potential of antisense: beyond phosphorothioate oligodeoxynucleotides.
Phosphorothioate oligodeoxynucleotides, designed as nuclease-resistant antisense agents, appear to have a number of surprising biological effects that are unrelated to their intended antisense activity. These effects may be useful in themselves, but must be understood for the full potential of antisense technology to be realized.
Stein
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Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.
D004705:Endocytosis; D006493:Heparin / Q000378:metabolism; D016376:Oligonucleotides, Antisense / Q000378:metabolism / Q000494:pharmacology*; D009943:Organophosphorus Compounds / Q000378:metabolism / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism
D016376:Oligonucleotides, Antisense; D009943:Organophosphorus Compounds; D011956:Receptors, Cell Surface; D006493:Heparin