Osmotic nephrosis due to high-dose immunoglobulin therapy containing sucrose (but not with glycine) in a patient with immunoglobulin A nephritis.
Acute renal failure has been described as a complication of immunoglobulin therapy. It is not clear whether the immunoglobulin per se or the sucrose that is used as a stabilizer is the cause. We describe a patient with immunoglobulin A nephropathy who was treated with sucrose-containing immunoglobulin. He developed acute renal failure with osmotic nephrosis found on kidney biopsy. When using a glycine-containing immunoglobulin no acute renal impairment was observed in this patient.
Hansen-Schmidt
S
S
Department of Internal Medicine, University Hospital Ulm, Germany.
Silomon
J
J
Keller
F
F
D058186:Acute Kidney Injury / Q000209:etiology* / Q000473:pathology; D000328:Adult; D005922:Glomerulonephritis, IGA / Q000628:therapy*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000009:adverse effects*; D007668:Kidney / Q000473:pathology; D008297:Male; D009401:Nephrosis / Q000209:etiology* / Q000473:pathology; D009995:Osmosis; D013395:Sucrose
D016756:Immunoglobulins, Intravenous; D013395:Sucrose