Cadaver kidney transplantation in the north Italy transplant program in the nineties.
The most relevant changes which have taken place in the NITp in the nineties include the introduction of HLA-DRB1 matching, the extension of both recipient and donor selection criteria, and an increase in donor procurement and consequently, in transplantation activity. Some of the changes in policy resulted from extensive analysis of our previous experience. For the future years, the NITp has set the following priorities: Consolidate the increase of donor procurement activity registered in the past 15 months by educational campaigns for health workers and the public, and organizational measures aimed at strengthening ICUs, nominating transplant coordinators and introducing a system of reimbursement for organs procured. Improve the quality of results in terms of patient rehabilitation and cost-benefit through: continued evaluation of protocols for patient admission on the waiting lists and careful selection of donors; and prospective use of genomic HLA Class II matching and also consider genomic typing for HLA Class I which is almost a reality. Establish a single pool of patients on the waiting list evaluated according to common protocols with the possibility of performing the transplant in each of the authorized centers in turn, respecting the best HLA match and the local use of organs. Finally, standards for donor treatment, organ procurement, histocompatibility testing and transplantation must be established. For this purpose, accreditation programs which have begun to be applied in Europe seem to be the adequate tool.
Sirchia
G
G
North Italy Transplant Program and Regional Tissue Bank, Ospedale Maggiore Policlinico di Milano.
Mascaretti
L
L
Poli
F
F
Scalamogna
M
M
Pappalettera
M
M
Pizzi
C
C
D000293:Adolescent; D000328:Adult; D002102:Cadaver; D002648:Child; D005260:Female; D006085:Graft Survival; D006680:HLA Antigens; D006650:Histocompatibility Testing; D006801:Humans; D007558:Italy; D016030:Kidney Transplantation / Q000276:immunology / Q000401:mortality; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D015996:Survival Rate; D014019:Tissue Donors; D009927:Tissue and Organ Procurement; D014850:Waiting Lists
D006680:HLA Antigens