Sequential occurrence of hepatocellular carcinoma following Waldenström's macroglobulinemia: the pathogenetic role of chronic liver disease.
We report a case of sequential occurrence of hepatocellular carcinoma (HCC) following Waldenström's macroglobulinemia (WM) in the course of chronic liver disease. The diagnosis of WM was made in a 55-year-old man with a history of alcohol abuse. He developed HCC in the course of WM, and hepatitis C virus (HCV) infection was detected by enzyme-linked immunosorbent assay. Recent reports suggest that persistent HCV infection is related to the pathogenesis of B cell malignancy. Chronic liver disease may be associated with the pathogenesis of the double malignancies in the present case.
Izumi
T
T
Department of Medicine, Jichi Medical School, Tochigi.
Sasaki
R
R
Tsunoda
S
S
Hatakeyama
M
M
Koyama
H
H
Shinohara
N
N
Miura
Y
Y
D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000209:etiology*; D017809:Fatal Outcome; D006526:Hepatitis C / Q000097:blood / Q000150:complications*; D006521:Hepatitis, Chronic / Q000097:blood / Q000150:complications*; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000097:blood / Q000150:complications*; D008113:Liver Neoplasms / Q000097:blood / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D008258:Waldenstrom Macroglobulinemia / Q000097:blood / Q000209:etiology*