Involvement of signal transduction pathways in lung cancer biology.
Pathways involved in the transduction of biological signals within cells overlap with those involved in oncogenesis. Previous studies have identified a number of discrete disturbances of some elements of these pathways in human lung cancer cells, by virtue of the overexpression or the mutation of certain key molecules. The sequence of biochemical events triggered by a mitogenic stimulus such as the exposure to bombesin-like peptides are being unravelled. The opportunity exists to identify additional changes involving regulatory proteins which may contribute to the regulation of these systems and which may function as suppressors of the malignant phenotype. Furthermore, the understanding of these pathways may identify targets for the pharmacological regulation of tumor cell response to mitogens which may be usable in the clinic.
Viallet
J
J
Department of Medicine, Hôpital Notre-Dame, Montreal, P.Q., Canada.
Sausville
E A
EA
D001839:Bombesin / Q000494:pharmacology; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism*; D008934:Mitogens / Q000494:pharmacology; D009479:Neuropeptides / Q000494:pharmacology; D010766:Phosphorylation; D011494:Protein Kinases / Q000145:classification / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D018004:Receptors, Bombesin / Q000187:drug effects / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
D008934:Mitogens; D009479:Neuropeptides; D018004:Receptors, Bombesin; D011494:Protein Kinases; D019204:GTP-Binding Proteins; D001839:Bombesin