Frequent deletion of chromosome 1p sequences in an aggressive histologic subtype of endometrial cancer.
The molecular genetic events underlying endometrial tumorigenesis are ill-defined at present. We have identified a region on the short arm of chromosome 1 which is frequently deleted in endometrial cancers. The region of deletion has been localized to bands 1p32-33. Deletion of 1p32-33 is seen more frequently in cancers of the highly aggressive papillary serous type than in cancers of the less-aggressive endometrioid type. These data suggest the presence of a tumor suppressor gene on 1p32-33 which is specifically involved in the development of endometrial cancers with poor outcome.
Arlt
M F
MF
Department of Surgery, Washington University School of Medicine, St Louis MO 63110, USA.
Herzog
T J
TJ
Mutch
D G
DG
Gersell
D J
DJ
Liu
H
H
Goodfellow
P J
PJ
D018262:Adenocarcinoma, Clear Cell / Q000235:genetics; D018269:Carcinoma, Endometrioid / Q000235:genetics; D002872:Chromosome Deletion; D002877:Chromosomes, Human / Q000235:genetics; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D018283:Cystadenocarcinoma, Papillary / Q000235:genetics*; D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D006579:Heterozygote; D006801:Humans; D018895:Microsatellite Repeats; D011110:Polymorphism, Genetic
D005819:Genetic Markers