The neurochemistry of Parkinson's disease--comments on present and future developments.
The neurochemistry of Parkinson's disease is currently undergoing considerable changes. From the analysis of diseased tissue and of lesion models, attention has turned to basic questions of neuronal development and neuronal death including the role played by trophic factors in the protection and regeneration of nervous tissue. Here some aspects are highlighted which emphasize molecular targets of possible causes and of future therapies, e.g., transmitter transporters and novel trophic effectors.
Hucho
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Institute of Biochemistry, Free University of Berlin, Federal Republic of Germany.
D000110:Acetylcholinesterase / Q000502:physiology; D002091:Butyrylcholinesterase / Q000502:physiology; D016166:Free Radical Scavengers / Q000494:pharmacology / Q000627:therapeutic use*; D015316:Genetic Therapy; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D018377:Neurotransmitter Agents / Q000378:metabolism / Q000502:physiology; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D010300:Parkinson Disease / Q000378:metabolism* / Q000628:therapy
D016166:Free Radical Scavengers; D006133:Growth Substances; D018377:Neurotransmitter Agents; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase