title: [Quantitative assessment of an increase of myocardial 99mTc-MIBI accumulation during exercise--usefulness of response rate].
abstract: The increase of myocardial 99mTc-MIBI accumulation during exercise was evaluated quantitatively, and the feasibility of response rate as a noninvasive marker of coronary stenosis was tested. Myocardial perfusion imaging with 99mTc-MIBI during exercise and at rest was performed in patients with suspected coronary artery disease. A dose of 296 MBq of 99mTc-MIBI was injected intravenously at maximal treadmill exercise, and myocardial image was obtained 90 min later (1st image). Then, 740 MBq of 99mTc-MIBI was administered at rest, and myocardial image was repeated (2nd image). These images were corrected for a decay and injected dose, and the 1st image was subtracted from the 2nd image to obtain the rest image. An increase of myocardial accumulation of 99mTc-MIBI during exercise was defined as (exercise image-rest image) x 100/rest image (response rate). A response rate of a patient with normal coronary artery was 102%, whereas a response rate in the area of severe coronary stenosis was 21% in a patients with angina pectoris. After successful PTCA to a stenosed coronary artery, a response rate increased to 75% in this patient. Coronary perfusion reserve during exercise can be assessed noninvasively by 99mTc-MIBI. Response rate of 99mTc-MIBI provides additional information to conventional perfusion imaging and may be a new marker of severity of coronary artery disease.
authors.affiliation: Division of Radiology, Yamagata University School of Medicine.
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Takeishi
authors.forename: S
authors.initials: S
authors.lastname: Fujiwara
authors.forename: H
authors.initials: H
authors.lastname: Atsumi
authors.forename: T
authors.initials: T
authors.lastname: Akutsu
authors.forename: A
authors.initials: A
authors.lastname: Komatani
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
mesh_terms: D015415:Biomarkers; D003326:Coronary Circulation; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005080:Exercise Test; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D017256:Technetium Tc 99m Sestamibi / Q000493:pharmacokinetics*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015415:Biomarkers; D017256:Technetium Tc 99m Sestamibi