A new twist to the tale? Apoptosis.
The DNA helicases XPB and XPD, components of transcription factor TFIIH, have been implicated in a p53-induced apoptotic pathway. These new findings suggest a role for the core TFIIH complex in the coordination, not only of transcription, the cell cycle and DNA repair, but also of apoptosis.
Warbrick
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Department of Anatomy and Physiology, Medical Sciences Institute, University of Dundee, Dundee DD1 4HN, Scotland, UK.
D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D004265:DNA Helicases / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology*; D006801:Humans; D011506:Proteins / Q000502:physiology*; D015398:Signal Transduction; D051758:Transcription Factor TFIIH; D014157:Transcription Factors / Q000378:metabolism / Q000502:physiology*; D019473:Transcription Factors, TFII; D014158:Transcription, Genetic; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000502:physiology*; D051759:Xeroderma Pigmentosum Group D Protein
D004268:DNA-Binding Proteins; D011506:Proteins; D014157:Transcription Factors; D019473:Transcription Factors, TFII; D016159:Tumor Suppressor Protein p53; C072022:XPBC-ERCC-3 protein; D051758:Transcription Factor TFIIH; D018844:Cyclin-Dependent Kinases; D004265:DNA Helicases; D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human