Replication of DNA containing cisplatin lesions and its mutagenic consequences.
Cisplatin [cis-diamminedichloroplatinum II] is widely used in the treatment of a broad range of tumors. A number of biological and biochemical results indicate that the reaction of cisplatin with DNA is responsible for the cytotoxic action of the drug. However, cisplatin can induce mutagenesis and may be carcinogenic in humans. Error prone replication of damaged DNA must be considered as a possible mechanism of mutagenesis. In this short review, we present data indicating that DNA containing cisplatin lesions can be replicated by prokaryotes and eukaryotes in a mutagenic fashion.
Pillaire
M J
MJ
Laboratoire de Pharmacologie et Toxicologie Fondamentales du CNRS, Toulouse, France.
Hoffmann
J S
JS
Defais
M
M
Villani
G
G
D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D002945:Cisplatin / Q000494:pharmacology*; D004247:DNA / Q000187:drug effects*; D004261:DNA Replication / Q000187:drug effects*; D006801:Humans; D016296:Mutagenesis
D002273:Carcinogens; D004247:DNA; D002945:Cisplatin