title: Randomized, controlled phase I/II, trial of combination therapy with delavirdine (U-90152S) and conventional nucleosides in human immunodeficiency virus type 1-infected patients.
abstract: Delavirdine mesylate (DLV) is a potent nonnucleoside reverse transcriptase inhibitor with activity specific for human immunodeficiency virus type 1. In the present phase I/II study we evaluated the safety, toxicity, pharmacokinetics, and antiretroviral activities of two-drug and three-drug combinations of DLV and conventional doses of nucleoside analogs compared with those of both DLV monotherapy and two-drug nucleoside analog therapy. A total of 85 human immunodeficiency virus type 1 infected patients with CD4 counts of 100 to 300 cells per mm3 were enrolled in two periods: in the first period patients were randomized to receive either zidovudine (ZDV) plus didanosine (group 1) or ZDV plus didanosine plus escalating doses (400 to 1,200 mg/day) of DLV (group 2). In the second period, patients were randomized to receive either 1,200 mg of DLV alone per day (group 3) or ZDV plus 1,200 mg of DLV per day (group 4). DLV demonstrated good oral bioavailability at all five doses tested. The major toxicity was a transient mild rash which appeared in 44% of all DLV recipients. Overall, group 2 patients demonstrated more sustained improvements in CD4 counts, percent CD4 cells, branched DNA levels, p24 antigen levels, and virus titers in plasma than group 1, 3, or 4 patients. The magnitude of the response correlated with the intensity of prior nucleoside analog treatment, the non-syncytium-inducing or syncytium-inducing viral phenotype at baseline, and the presence of a wild-type codon at amino acid position 215 in the baseline reverse transcriptase genotype. Despite a transient rash, DLV therapy was well tolerated. Combination therapy with DLV and nucleoside analogs appears promising, with the three-drug combination appearing to be more potent that either two-drug combinations or monotherapy.
authors.affiliation: National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, USA. rdavey@pop.niaid.nih.gov
authors.forename: R T
authors.initials: RT
authors.lastname: Davey
authors.forename: D G
authors.initials: DG
authors.lastname: Chaitt
authors.forename: G F
authors.initials: GF
authors.lastname: Reed
authors.forename: W W
authors.initials: WW
authors.lastname: Freimuth
authors.forename: B R
authors.initials: BR
authors.lastname: Herpin
authors.forename: J A
authors.initials: JA
authors.lastname: Metcalf
authors.forename: P S
authors.initials: PS
authors.lastname: Eastman
authors.forename: J
authors.initials: J
authors.lastname: Falloon
authors.forename: J A
authors.initials: JA
authors.lastname: Kovacs
authors.forename: M A
authors.initials: MA
authors.lastname: Polis
authors.forename: R E
authors.initials: RE
authors.lastname: Walker
authors.forename: H
authors.initials: H
authors.lastname: Masur
authors.forename: J
authors.initials: J
authors.lastname: Boyle
authors.forename: S
authors.initials: S
authors.lastname: Coleman
authors.forename: S R
authors.initials: SR
authors.lastname: Cox
authors.forename: L
authors.initials: L
authors.lastname: Wathen
authors.forename: C L
authors.initials: CL
authors.lastname: Daenzer
authors.forename: H C
authors.initials: HC
authors.lastname: Lane
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D001682:Biological Availability; D020008:Delavirdine; D016049:Didanosine / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1; D006801:Humans; D007211:Indoles / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*; D015215:Zidovudine / Q000627:therapeutic use*
chemical_list: D019380:Anti-HIV Agents; D007211:Indoles; D010879:Piperazines; D018894:Reverse Transcriptase Inhibitors; D015215:Zidovudine; D020008:Delavirdine; D016049:Didanosine