Five years on the wings of fork head.
Since its discovery five years ago the conserved family of fork head/HNF-3-related transcription factors has gained increasing importance for the analysis of gene regulatory mechanisms during embryonic development and in differentiated cells. Different members of this family, which is defined by a conserved 110 amino acid residues encompassing DNA binding domain of winged helix structure, serve as regulatory keys in embryogenesis, in tumorigenesis or in the maintenance of differentiated cell states. The purpose of this review is to summarize the accumulating amount of data on structure, expression and function of fork head/HNF-3-related transcription factors.
Kaufmann
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E
Abteilung Biochemie, Universität Ulm, Germany.
Knöchel
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W
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites / Q000502:physiology; D017173:Caenorhabditis elegans / Q000235:genetics; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics; D004330:Drosophila / Q000235:genetics; D005544:Forecasting; D051858:Forkhead Transcription Factors; D018507:Gene Expression Regulation, Developmental; D051542:Hepatocyte Nuclear Factor 3-beta; D008562:Membrane Glycoproteins; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000235:genetics; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D017386:Sequence Homology, Amino Acid; D019699:Thrombospondins; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D014178:Translocation, Genetic; D014714:Vertebrates / Q000235:genetics; D015003:Yeasts / Q000235:genetics
D004268:DNA-Binding Proteins; D051858:Forkhead Transcription Factors; D008562:Membrane Glycoproteins; D009687:Nuclear Proteins; D019699:Thrombospondins; D014157:Transcription Factors; D051542:Hepatocyte Nuclear Factor 3-beta