No significant effect of age of onset on response to anti-asthmatic medications in adult asthmatics.
In order to know the effect of age of onset on response to antiasthmatic medications in adult asthmatics, the changes in bronchial hyper-responsiveness and symptoms were retrospectively assessed following four to five month-treatments in patients with a less than two-year history of asthma. There was no significant difference in regimens among the three groups. The histamine PC20 value increased significantly from 456 to 1015 micrograms/ml in group A (20-39 yrs), 531 to 2363 micrograms/ml in group B (40-59 yrs), and 256 to 1148 micrograms/ml in group C (60 < or =) following the administration of the agents for four to five months. The percentage of patients who became symptom-free also increased significantly in each group along with a decrease in the bronchial hyper-responsiveness. There was no significant difference in the degrees of improvement in bronchial hyper-responsiveness and symptoms. These results suggest that the age of onset of asthma may not be related to the response to anti-asthmatic medications in adult asthmatics.
Oosaki
R
R
First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.
Mizushima
Y
Y
Kawasaki
A
A
Kashii
T
T
Kobayashi
M
M
D000328:Adult; D017668:Age of Onset; D000368:Aged; D001249:Asthma / Q000188:drug therapy*; D001507:Beclomethasone / Q000627:therapeutic use*; D016535:Bronchial Hyperreactivity / Q000188:drug therapy; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
D001993:Bronchodilator Agents; D001507:Beclomethasone