Telomere shortening, ageing, and chromosome damage.
A relationship between telomere shortening and ageing has been established. A series of young and elderly healthy donors. Alzheimer disease patients, young and old Down's syndrome individuals were cytogenetically analyzed. No preferential damage in distal bands was seen in age-related chromosome instability.
Kormann-Bortolotto
M H
MH
UNIFESP-Escola Paulista de Medicina, Depto. de Morfologia, São Paulo, SP, Brazil.
Borsatto
B
B
Smith
M
M
D000375:Aging / Q000235:genetics*; D000544:Alzheimer Disease / Q000235:genetics*; D016022:Case-Control Studies; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D004314:Down Syndrome / Q000235:genetics*; D006801:Humans; D016615:Telomere / Q000648:ultrastructure*