title: Brain aging in normal Egyptians: neuropsychological, electrophysiological and cranial tomographic assessment.
abstract: Eighty-eight normal Egyptian volunteers above the age of 40 years were studied for brain aging and subjected to neuropsychological (the Paced Auditory Serial Addition Test; the Trailmaking test A, B; the Digit Symbol Substitution Test; sensory and secondary memory tests), electrophysiological (computerized EEG, P300 and reaction time measures), and Computerized Cranial Tomography (CCT) assessment. A significant correlation was found between age and both perception (Digit Symbol Substitution Test (DDST) and psychomotor performance (Trailmaking B test (TMb)), reaction time (RT) and the size of the third ventricle. Whereas females were worse in attention (Paced Auditory Serial Addition Test (PASAT)), males had worse performance in secondary memory test. Elderly subjects with vascular risk factors did worse in psychomotor performance (TMa) than subjects with no risk factors. Non-educated subjects showed worse perception (DSST) than educated subjects. A significant decrease in upper and lower limit percent power of the alpha band was found in subjects above 60 years, males, and non-educated subjects. A significant increase in theta activity was found only in non-educated subjects. It is concluded that decline in specific cognitive functions occurs with advancing age. Vascular risk factors and lack of education early in life enhance these changes. Moreover, the EEG slowing in the elderly was linked to lack of education early in life.
authors.affiliation: Department of Neurology, Cairo University, Egypt.
authors.forename: O
authors.initials: O
authors.lastname: Elwan
authors.forename: A A
authors.initials: AA
authors.lastname: Hassan
authors.forename: M
authors.initials: M
authors.lastname: Abdel Naseer
authors.forename: M
authors.initials: M
authors.lastname: Fahmy
authors.forename: F
authors.initials: F
authors.lastname: Elwan
authors.forename: A
authors.initials: A
authors.lastname: Abel Kader
authors.forename: M
authors.initials: M
authors.lastname: Mahfouz
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001288:Attention / Q000502:physiology; D001921:Brain / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000502:physiology*; D003071:Cognition / Q000502:physiology; D004493:Education; D004534:Egypt; D004569:Electroencephalography; D004594:Electrophysiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012016:Reference Values; D012307:Risk Factors; D014054:Tomography; D014057:Tomography, X-Ray Computed