RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.
The RXR gamma (RXR, retinoid X receptor) gene was disrupted in the mouse. Homozygous mutant mice developed normally and were indistinguishable from their RXR gamma +/- or wild-type littermates with respect to growth, fertility, viability, and apparent behavior in the animal facility. Moreover, RXR alpha -/-/RXR gamma -/- and RXR beta -/-/RXR gamma -/- mutant phenotypes were indistinguishable from those of RXR alpha -/- and RXR beta -/- mutants, respectively. Strikingly, RXR alpha +/-/RXR beta -/-/RXR gamma -/- triple mutants were viable. Thus, it appears that RXR gamma does not exert any essential function that cannot be performed by RXR alpha or RXR beta, and one copy of RXR alpha is sufficient to perform most of the functions of the RXRs.
Krezel
W
W
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Collège de France, Illkirch, France.
Dupé
V
V
Mark
M
M
Dierich
A
A
Kastner
P
P
Chambon
P
P
D000818:Animals; D001835:Body Weight; D006579:Heterozygote; D006720:Homozygote; D051379:Mice; D018345:Mice, Knockout / Q000196:embryology / Q000254:growth & development; D008969:Molecular Sequence Data; D024510:Muscle Development; D018482:Muscle, Skeletal / Q000737:chemistry / Q000196:embryology / Q000254:growth & development; D012333:RNA, Messenger / Q000302:isolation & purification; D018168:Receptors, Retinoic Acid / Q000235:genetics* / Q000302:isolation & purification; D047488:Retinoid X Receptors; D014018:Tissue Distribution; D014157:Transcription Factors / Q000235:genetics* / Q000302:isolation & purification
D012333:RNA, Messenger; D018168:Receptors, Retinoic Acid; D047488:Retinoid X Receptors; D014157:Transcription Factors