title: In vitro interleukin-1 and 2 production and interleukin 2 receptor expression in the rhesus monkey.
abstract: Anti-human monoclonal antibodies were used to detect and quantify interleukins-1 and 2 and interleukin-2 receptor expression in peripheral blood mononuclear cells from a rhesus monkey. Interleukin-1 production could be induced by phorbol esters (PMA) and was potentiated by phytohemagglutinin (PHA). Interleukin-2 secretion could also be induced by the combination of PHA and PMA, but only weakly with PHA alone. Interleukin-2 receptor expression was present in a subpopulation of unstimulated lymphocytes and could be enhanced by PHA or PMA. These data show once again that the rhesus monkey immune system is cross-reactive with the human one and that rhesus macaque could be a good model to study interleukin therapy.
authors.affiliation: Laboratoire d'Immunologie, Faculté de Médecine et CHU Rangueil, Toulouse, France.
authors.forename: D A
authors.initials: DA
authors.lastname: Schmitt
authors.forename: G
authors.initials: G
authors.lastname: Sonnenfeld
authors.forename: D
authors.initials: D
authors.lastname: Husson
authors.forename: J
authors.initials: J
authors.lastname: Tkaczuk
authors.forename: E
authors.initials: E
authors.lastname: André
authors.forename: L
authors.initials: L
authors.lastname: Schaffar
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D007375:Interleukin-1 / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008253:Macaca mulatta; D010835:Phytohemagglutinins / Q000494:pharmacology; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D007375:Interleukin-1; D007376:Interleukin-2; D010835:Phytohemagglutinins; D015375:Receptors, Interleukin-2; D013755:Tetradecanoylphorbol Acetate