Hypoglycemic and aldose reductase activity of Polichia campestris.
The hypoglycemic activity of 80% methanol extract of Polichia campestris (PM) was investigated in both normal and streptozotocin-induced diabetic mice, one of the insulin-dependent diabetic mellitus. PM (300 mg/kg) reduced the blood glucose of normal mice from 2 to 7 h after oral administration. It also decreased hyperglycemia from 594 +/- 46 to 472 +/- 31 mg/dl 4 h after oral administration in streptozotocin-induced diabetic mice (p < 0.05). PM strongly increased glucose uptake in adipose tissues. In addition, the petroleum ether fraction of PM inhibited aldose reductase activity. These experimental results suggest that the antidiabetic activity of Polichia campestris supports its use in traditional medicine.
Miura
T
T
Suzuka University of Medical Science and Technology, Japan.
Kato
A
A
D000273:Adipose Tissue / Q000378:metabolism; D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D013311:Streptozocin
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D013311:Streptozocin; D000449:Aldehyde Reductase