title: Estimation of in vivo proton intrinsic and cross-relaxation rate in human brain.
abstract: By using on-resonance binomial pulse saturation of the immobile component in tissues and by monitoring the time development of the longitudinal decay of the free water magnetization, it has been shown that it is possible to estimate physical model parameters not directly measurable by conventional methods. Since pulsed saturation is easy and safe to implement in a clinical MRI machine, it should be possible to estimate these parameters in vivo by the same means. In this article, we report the results of such estimates of the parameters of the principal components (gray and white matter) in brains of two normal volunteers.
authors.affiliation: Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China.
authors.forename: J W
authors.initials: JW
authors.lastname: Chai
authors.forename: C
authors.initials: C
authors.lastname: Chen
authors.forename: J H
authors.initials: JH
authors.lastname: Chen
authors.forename: S K
authors.initials: SK
authors.lastname: Lee
authors.forename: H N
authors.initials: HN
authors.lastname: Yeung
mesh_terms: D000328:Adult; D000465:Algorithms; D001834:Body Water / Q000378:metabolism; D001921:Brain / Q000033:anatomy & histology*; D002555:Cerebrospinal Fluid / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D011522:Protons
chemical_list: D011522:Protons