title: Understanding and controlling the cell cycle with natural products.
abstract: Small molecule natural products have aided in the discovery and characterization of many proteins critical to the progression and maintenance of the cell cycle. Identification of the direct target of a natural product gives scientists a tool to control a specific aspect of the cell cycle, thus facilitating the study of the cell-cycle machinery.
authors.affiliation: Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
authors.forename: D T
authors.initials: DT
authors.lastname: Hung
authors.forename: T F
authors.initials: TF
authors.lastname: Jamison
authors.forename: S L
authors.initials: SL
authors.lastname: Schreiber
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology* / Q000502:physiology; D002453:Cell Cycle / Q000187:drug effects* / Q000502:physiology; D004249:DNA Damage; D015394:Molecular Structure; D019384:Nucleic Acid Synthesis Inhibitors / Q000737:chemistry / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
chemical_list: D001688:Biological Products; D019384:Nucleic Acid Synthesis Inhibitors