title: Encoding of sequence and boundaries of scripts following prefrontal lesions.
abstract: Script analysis was investigated in patients with lesions in the prefrontal (n = 10) and posterior (n = 8) cortical regions, and in normal subjects (n = 15). The selection and temporal organization of relevant actions belonging to different pre-established sequences were studied in three different situations: (A) script with headers, (B) script with headers and distractors, and (C) scripts without headers. Contrarily to Normals and Posterior patients, Frontal patients committed sequence and boundary errors, and failed to eliminate distractors elements. The analysis of errors suggests two different cognitive modes of representing actions: (1) One using temporal contiguity between actions, that would be mainly under the control of the posterior associative areas; (2) the other, using the goal of the action and its consequences as a binding element between script and context, that would require the intervention of prefrontal cortex.
authors.affiliation: INSERM Unité 289, Hôpital de la Salpétrière, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Sirigu
authors.forename: T
authors.initials: T
authors.lastname: Zalla
authors.forename: B
authors.initials: B
authors.lastname: Pillon
authors.forename: J
authors.initials: J
authors.lastname: Grafman
authors.forename: Y
authors.initials: Y
authors.lastname: Agid
authors.forename: B
authors.initials: B
authors.lastname: Dubois
mesh_terms: D000293:Adolescent; D000328:Adult; D001930:Brain Injuries / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000293:injuries* / Q000473:pathology; D011932:Reading; D014057:Tomography, X-Ray Computed; D014796:Visual Perception / Q000502:physiology*