title: D-amphetamine challenge effects on Wisconsin Card Sort Test. Performance in schizotypal personality disorder.
abstract: The authors assessed the effects on Wisconsin Card Sort (WCST) performance and psychiatric symptoms of 30 mg d-amphetamine, a dopamine and norepinephrine agonist, vs placebo in nine patients with schizotypal personality disorder (SPD). Patients, particularly those who made more perseverative errors, demonstrated amphetamine-associated improvement on WCST performance. The data in this preliminary study suggest that some of the cognitive dysfunction present in SPD may improve with amphetamine challenge.
authors.affiliation: Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.
authors.forename: B V
authors.initials: BV
authors.lastname: Siegel
authors.forename: R L
authors.initials: RL
authors.lastname: Trestman
authors.forename: S
authors.initials: S
authors.lastname: O'Flaithbheartaigh
authors.forename: V
authors.initials: V
authors.lastname: Mitropoulou
authors.forename: F
authors.initials: F
authors.lastname: Amin
authors.forename: R
authors.initials: R
authors.lastname: Kirrane
authors.forename: J
authors.initials: J
authors.lastname: Silverman
authors.forename: J
authors.initials: J
authors.lastname: Schmeidler
authors.forename: R S
authors.initials: RS
authors.lastname: Keefe
authors.forename: L J
authors.initials: LJ
authors.lastname: Siever
mesh_terms: D000328:Adult; D000368:Aged; D001143:Arousal / Q000502:physiology; D001288:Attention / Q000502:physiology; D003072:Cognition Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D003913:Dextroamphetamine; D004298:Dopamine / Q000502:physiology; D015259:Dopamine Agents; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009638:Norepinephrine / Q000502:physiology; D011340:Problem Solving / Q000502:physiology; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology; D012569:Schizotypal Personality Disorder / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology
chemical_list: D015259:Dopamine Agents; D003913:Dextroamphetamine; D004298:Dopamine; D009638:Norepinephrine