title: Genetic relationship between dopamine transporter gene and schizophrenia: linkage and association.
abstract: This study explores the genetic relationship between schizophrenia and the dopamine transporter gene (DAT) by a variety of methods. In a sample of 48 families--each family containing at least one nuclear family with a pair of affected siblings--we performed linkage analysis using the maximum likelihood (LOD score) method as well as sibpair analysis (identity by descent). In addition, we investigated a sample of 108 nuclear families--index case affected with schizophrenia/chronic schizoaffective disorder--for association using the haplotype relative risk method. Linkage between schizophrenia and DAT using two- and three-point linkage analysis was excluded with all disease models employed. No evidence for association between haplotypes of the VNTR-probe of the DAT and schizophrenia has been detected. Thus, a contribution of the DAT gene to the genetic diathesis of schizophrenia is unlikely in the families studied.
authors.affiliation: Department of Psychiatry, University of Mainz, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Maier
authors.forename: J
authors.initials: J
authors.lastname: Minges
authors.forename: N
authors.initials: N
authors.lastname: Eckstein
authors.forename: C
authors.initials: C
authors.lastname: Brodski
authors.forename: M
authors.initials: M
authors.lastname: Albus
authors.forename: B
authors.initials: B
authors.lastname: Lerer
authors.forename: J
authors.initials: J
authors.lastname: Hallmayer
authors.forename: R
authors.initials: R
authors.lastname: Fimmers
authors.forename: M
authors.initials: M
authors.lastname: Ackenheil
authors.forename: R E
authors.initials: RE
authors.lastname: Ebstein
authors.forename: M
authors.initials: M
authors.lastname: Borrmann
authors.forename: D
authors.initials: D
authors.lastname: Lichtermann
authors.forename: D B
authors.initials: DB
authors.lastname: Wildenauer
mesh_terms: D000328:Adult; D002352:Carrier Proteins / Q000235:genetics*; D002908:Chronic Disease; D050483:Dopamine Plasma Membrane Transport Proteins; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D018598:Minisatellite Repeats / Q000235:genetics; D008957:Models, Genetic; D009419:Nerve Tissue Proteins; D010641:Phenotype; D011618:Psychotic Disorders / Q000175:diagnosis / Q000235:genetics; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*
chemical_list: D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D005819:Genetic Markers; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493214:SLC6A3 protein, human