title: Effects of the mycelial extract of cultured Cordyceps sinensis on in vivo hepatic energy metabolism in the mouse.
abstract: Mice were given the extract of cultured Cordyceps sinensis (Cs) (200 mg/kg daily, p.o.) for 3 weeks. In vivo phosphorus-31 nuclear magnetic resonance (NMR) spectra of the liver were acquired at weekly intervals using a surface coil. From 1 to 3 weeks, a consistent increase in the ATP/inorganic phosphate ratio, which represents the high energy state, was observed in the Cs extract-treated mice. The intracellular pH of the Cs extract-treated mice was not significantly different from that of the control mice. No steatosis, necrosis, inflammation or fibrosis were observed in the liver specimens from Cs extract-treated mice.
authors.affiliation: Department of Animal Science, Kyoto University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Manabe
authors.forename: M
authors.initials: M
authors.lastname: Sugimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Azuma
authors.forename: N
authors.initials: N
authors.lastname: Taketomo
authors.forename: A
authors.initials: A
authors.lastname: Yamashita
authors.forename: H
authors.initials: H
authors.lastname: Tsuboi
authors.forename: A
authors.initials: A
authors.lastname: Tsunoo
authors.forename: N
authors.initials: N
authors.lastname: Kinjo
authors.forename: H
authors.initials: H
authors.lastname: Nian-Lai
authors.forename: H
authors.initials: H
authors.lastname: Miyamoto
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004734:Energy Metabolism; D006863:Hydrogen-Ion Concentration; D006999:Hypocreales; D008099:Liver / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010710:Phosphates / Q000378:metabolism; D010758:Phosphorus
chemical_list: D004365:Drugs, Chinese Herbal; D010710:Phosphates; D010758:Phosphorus; D000255:Adenosine Triphosphate