Successful treatment of phenol poisoning with charcoal hemoperfusion.
A 50-y-old Caucasian female inadvertantly received 30 ml of 89% phenol (26.9 g, 0.44 g/kg bw) [corrected]. At 23 min post-injection the patient was unresponsive and in shock. By 4 h post-injection she required large doses of vasopressors. At 4.5 h, charcoal hemoperfusion (CHP) was begun and she received that for 6 h and 20 min. Her clinical status improved during the CHP and she made a complete recovery. Phenol levels drawn prior to and after the procedure correlated her recovery with the improving phenol levels. CHP appears to have efficacy in severe acute phenol intoxication.
Christiansen
R G
RG
Department of Nephrology, University of Illinois College of Medicine-Rockford 61107, USA.
Klaman
J S
JS
D001798:Blood Proteins / Q000378:metabolism; D002606:Charcoal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002908:Chronic Disease; D005260:Female; D006464:Hemoperfusion; D006801:Humans; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000188:drug therapy; D007677:Kidney Function Tests; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008875:Middle Aged; D010195:Pancreatitis / Q000188:drug therapy; D019800:Phenol; D010636:Phenols / Q000097:blood / Q000506:poisoning* / Q000627:therapeutic use; D011041:Poisoning / Q000628:therapy; D016896:Treatment Outcome
D001798:Blood Proteins; D010636:Phenols; D002606:Charcoal; D019800:Phenol; D007770:L-Lactate Dehydrogenase