title: Ethylene-oxide and steam-sterilised polysulfone membrane in dialysis patients with eosinophilia.
abstract: Eosinophilia and some acute dialysis side-effects, such as itching, flushing and bronchospasm, are often associated with the presence of ethylene oxide (ETO) as dialyzer sterilizing agent. This study evaluated the effects of two different polysulfone (PS) hollow-fiber dialysers sterilized with ETO and steam in 31 chronic dialysis patients with eosinophilia. Clinical symptoms, metabolic and biochemical parameters, complement (C3a and C5a) activation and production were evaluated in each patient dialysed for two months at a time with Cuprophan dialyser, ETO-PS dialyser and steam-PS dialyser. The steam-sterilizer agent does not alter the purifying capacity of the PS membrane which maintains its superiority over Cuprophan in terms of biocompatibility. Using steam-PS, intradialytic eosinophil kinetics seems to improve. In some patients with high serum levels of ETO-specific IgE these levels tend to diminish. Generic intradialytic symptoms do not differ between the two sterilization methods, although some hypersensitivity symptoms during the first dialysis hour are considerably lower in some patients when steam-sterilized PS is used.
authors.affiliation: Laboratorio Analisi Chimico-Cliniche, Ospedali Riuniti, Bergamo, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Santoro
authors.forename: G
authors.initials: G
authors.lastname: Ferrari
authors.forename: A
authors.initials: A
authors.lastname: Francioso
authors.forename: P
authors.initials: P
authors.lastname: Zucchelli
authors.forename: E
authors.initials: E
authors.lastname: Duranti
authors.forename: M
authors.initials: M
authors.lastname: Sasdelli
authors.forename: A
authors.initials: A
authors.lastname: Rosati
authors.forename: M
authors.initials: M
authors.lastname: Salvadori
authors.forename: G M
authors.initials: GM
authors.lastname: Sanna
authors.forename: M
authors.initials: M
authors.lastname: Briganti
authors.forename: M
authors.initials: M
authors.lastname: Fusaroli
authors.forename: G
authors.initials: G
authors.lastname: Lindner
authors.forename: A
authors.initials: A
authors.lastname: Stefani
authors.forename: P
authors.initials: P
authors.lastname: Borgatti
authors.forename: F
authors.initials: F
authors.lastname: Badiali
authors.forename: R
authors.initials: R
authors.lastname: Mignani
authors.forename: L
authors.initials: L
authors.lastname: Cagnoli
authors.forename: F
authors.initials: F
authors.lastname: Aucella
authors.forename: C
authors.initials: C
authors.lastname: Stallone
authors.forename: M
authors.initials: M
authors.lastname: Massazza
authors.forename: M
authors.initials: M
authors.lastname: Borghi
authors.forename: L
authors.initials: L
authors.lastname: Gualandris
authors.forename: S
authors.initials: S
authors.lastname: Modoni
authors.forename: E
authors.initials: E
authors.lastname: Grandone
authors.forename: G
authors.initials: G
authors.lastname: Orlandini
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001639:Bicarbonates / Q000378:metabolism; D001672:Biocompatible Materials; D002482:Cellulose / Q000031:analogs & derivatives / Q000627:therapeutic use; D015926:Complement C3a / Q000378:metabolism; D015936:Complement C5a / Q000378:metabolism; D015314:Dialysis Solutions / Q000592:standards; D004797:Enzyme-Linked Immunosorbent Assay; D004802:Eosinophilia / Q000503:physiopathology*; D005027:Ethylene Oxide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010196:Pancreatic Elastase / Q000097:blood; D011108:Polymers / Q000627:therapeutic use; D011863:Radioimmunoassay; D006435:Renal Dialysis / Q000592:standards*; D013227:Steam; D013242:Sterilization / Q000592:standards; D013450:Sulfones / Q000627:therapeutic use
chemical_list: D001639:Bicarbonates; D001672:Biocompatible Materials; D015314:Dialysis Solutions; D008567:Membranes, Artificial; D011108:Polymers; D013227:Steam; D013450:Sulfones; C017662:polysulfone P 1700; D007073:Immunoglobulin E; D015926:Complement C3a; D015936:Complement C5a; D002482:Cellulose; C009865:cuprammonium cellulose; D010196:Pancreatic Elastase; D005027:Ethylene Oxide