Molecular mechanisms for focal adhesion assembly through regulation of protein-protein interactions.
Focal adhesions provide a useful model for studying cell/extracellular matrix interactions and the subsequent cytoskeletal reorganization. Recent advances have suggested potential mechanisms by which cells may regulate focal adhesion assembly following integrin-mediated cell adhesion.
Gilmore
A P
AP
Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill 27599, USA.
Burridge
K
K
D000199:Actins / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism*; D005353:Fibronectins / Q000378:metabolism; D051416:Focal Adhesion Protein-Tyrosine Kinases; D016023:Integrins / Q000378:metabolism*; D008958:Models, Molecular; D011505:Protein-Tyrosine Kinases / Q000378:metabolism
D000199:Actins; D015815:Cell Adhesion Molecules; D005353:Fibronectins; D016023:Integrins; D011505:Protein-Tyrosine Kinases; D051416:Focal Adhesion Protein-Tyrosine Kinases