The poliovirus receptor: a hook, or an unzipper?
The cell receptor for poliovirus may be more than a simple "snare' that attaches virus to cells. Recent results indicate that receptor binding may cause conformational changes in the virus that lead to uncoating of the viral RNA.
Racaniello
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Department of Microbiology, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA. racaniello@cuccfa.ccc.columbia.edu
D002213:Capsid / Q000737:chemistry; D008561:Membrane Fusion; D008565:Membrane Proteins; D008968:Molecular Conformation; D017955:Poliovirus / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D012367:RNA, Viral / Q000235:genetics; D011991:Receptors, Virus / Q000502:physiology*
D008565:Membrane Proteins; D012367:RNA, Viral; D011991:Receptors, Virus; C066100:poliovirus receptor