title: An Epstein Barr virus-related cross reactive autoimmune response in multiple sclerosis in Norway.
abstract: In studies of patients in Norway with multiple sclerosis (MS), we have found cross reactive autoantibodies related to the Epstein Barr virus nuclear antigen-1 (EBNA-1). The MS patients had elevated IgG antibody to EBNA-1, as measured by reactivity with a synthetic glycine/alanine peptide, P62, which represents the glycine/alanine repeat in EBNA-1. The mean titer of anti-P62 in patients with acute relapse at the time of assay was significantly higher than in the remaining patients. Patients with remitting/relapsing MS also had elevated autoantibody to a lymphocyte protein, p542, cross reactive with EBNA-1 through a glycine/serine epitope. High titered anti-EBNA-1 antibodies from some MS, as well as from some SLE sera, were shown to cross react with 80-82 kDa and 60 kDa proteins in neuroglial cells.
authors.affiliation: Department of Medicine-0663, University of California, San Diego, La Jolla 92093, USA. jvaughan@ucsd.edu
authors.forename: J H
authors.initials: JH
authors.lastname: Vaughan
authors.forename: T
authors.initials: T
authors.lastname: Riise
authors.forename: G H
authors.initials: GH
authors.lastname: Rhodes
authors.forename: M D
authors.initials: MD
authors.lastname: Nguyen
authors.forename: E
authors.initials: E
authors.lastname: Barrett-Connor
authors.forename: H
authors.initials: H
authors.lastname: Nyland
mesh_terms: D000595:Amino Acid Sequence; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000737:chemistry / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D003429:Cross Reactions; D019309:Epstein-Barr Virus Nuclear Antigens / Q000276:immunology*; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D009103:Multiple Sclerosis / Q000276:immunology*; D009664:Norway; D010455:Peptides / Q000276:immunology
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D019309:Epstein-Barr Virus Nuclear Antigens; D010455:Peptides