title: Antiretroviral drug resistance: mechanisms, pathogenesis, clinical significance.
abstract: The contribution of HIV drug resistance to treatment failure, the relationship of drug resistance to pathogenesis and the impact of resistance in the role of the promising new class of protease inhibitors remain areas of active investigation. A more precise understanding of these aspects of antiretroviral drug resistance will permit the more effective use of available drugs and the design of new drugs and drug regimens.
authors.affiliation: San Diego Veterans Affairs Medical Center, La Jolla, California, USA.
authors.forename: D D
authors.initials: DD
authors.lastname: Richman
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial / Q000235:genetics; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology; D017320:HIV Protease Inhibitors / Q000494:pharmacology; D006801:Humans; D012190:Retroviridae / Q000187:drug effects* / Q000235:genetics; D012192:Retroviridae Infections / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D017320:HIV Protease Inhibitors; D018894:Reverse Transcriptase Inhibitors