Antiviral activity of some hydroxycoumarin derivatives.
Esculetin (6,7-dihydroxycoumarin) and its diacetate exhibited a marked inhibitory effect on Newcastle disease virus replication in cell cultures at concentrations of 36 microM and 62 microM, respectively. These compounds were selected from ten hydroxycoumarin derivatives through an in vitro antiviral screen involving viruses of the picorna-, orthomyxo-, paramyxo-, and herpes virus families.
Galabov
A S
AS
Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Iosifova
T
T
Vassileva
E
E
Kostova
I
I
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002031:Bulgaria; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002642:Chick Embryo; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011558:Herpesvirus 1, Suid / Q000187:drug effects; D009980:Influenza A virus / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009522:Newcastle disease virus / Q000187:drug effects / Q000502:physiology; D010936:Plant Extracts; D018547:Plant Stems; D017955:Poliovirus / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D014197:Trees; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D003374:Coumarins; D010936:Plant Extracts