Hepatic epoxide concentrations during biotransformation of 1,2- and 1,4-dichlorobenzene: the use of in vitro and in vivo metabolism, kinetics and PB-PK modeling.
Hissink
E
E
TNO Toxicology, Zeist, The Netherlands.
van Ommen
B
B
Bogaards
J J
JJ
van Bladeren
P J
PJ
D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000493:pharmacokinetics* / Q000633:toxicity; D002722:Chlorobenzenes / Q000493:pharmacokinetics* / Q000633:toxicity; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004852:Epoxy Compounds / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D008954:Models, Biological; D051381:Rats; D017208:Rats, Wistar
D002273:Carcinogens; D002722:Chlorobenzenes; D004852:Epoxy Compounds; C004726:2-dichlorobenzene; D003577:Cytochrome P-450 Enzyme System; C018511:4-dichlorobenzene