Hepato-protective effect of daturaolone isolated from Solanum arundo.
The triterpene daturaolone was isolated for the first time from Solanum arundo Mattei. The structure has been elucidated by comparison of MS and 1H NMR spectra with the reported literature data, and was confirmed by 13C NMR. The compound proved its potency in reducing the harmful effects or in maintaining the normal hepatic physiological mechanisms in both acute and chronic hepato-toxic induced liver damage in rats.
Grace
M H
MH
Pharmaceutical Science Department, National Research Centre, Cairo, Egypt.
Saleh
M M
MM
D000818:Animals; D001663:Bilirubin / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology / Q000517:prevention & control; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D004798:Enzymes / Q000097:blood; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000378:metabolism; D011198:Solanum tuberosum / Q000737:chemistry*; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
D001798:Blood Proteins; D004798:Enzymes; D012709:Serum Albumin; D014315:Triterpenes; C007219:daturaolone; D001663:Bilirubin