Antiinflammatory activity of topically applied sertaconazole nitrate.
The antiinflammatory activity of topically applied sertaconazole nitrate was investigated. The dermal administration of 2% sertaconazole to rats, in which edema was induced by application of croton oil in the external ear, induced a 39.8% reduction of edema. The results show that sertaconazole applied by topical route at the concentration at which it is used in clinic, has antiinflammatory action in this experimental model.
Agut
J
J
Ferrer International Research Center, Barcelona, Spain.
Tarrida
N
N
Sacristán
A
A
Ortiz
J A
JA
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D003436:Croton Oil / Q000008:administration & dosage / Q000633:toxicity; D004423:Ear; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D007093:Imidazoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007509:Irritants / Q000008:administration & dosage / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000187:drug effects*; D013876:Thiophenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D007093:Imidazoles; D007509:Irritants; D013876:Thiophenes; C061131:sertaconazole; D003436:Croton Oil