title: [Oral surgical procedures during anticoagulant therapy].
abstract: Minor oral surgery, in patients being treated with anticoagulant therapy, constitutes a problem for the oral and maxillofacial surgeon. 77 patients getting coumarin underwent 168 oral surgical procedures (tooth extraction, apicoectomy, crown-lengthening, excision of lesions) without lowering the dose of anticoagulant. Local hemostasis was achieved in all cases by silk suture. For tooth extraction gelfoam was used as well. In 12 patients who presented with postoperative bleeding, it was controlled in all by gauze pressure with tranexamic acid and/or biologic glue and/or surgical splinting. Postoperative bleeding was not correlated with the international normalized ratio (INR), but with degree of local inflammation. The study shows that interruption of anticoagulant therapy in such cases is not justified, and the use of tranexamic acid or biological glue can control bleeding.
authors.affiliation: Dept. of Oral and Maxillofacial Surgery, Chaim Sheba Medical Center, Tel Hashomer.
authors.forename: D
authors.initials: D
authors.lastname: Blinder
authors.forename: U
authors.initials: U
authors.lastname: Martinowitz
authors.forename: L
authors.initials: L
authors.lastname: Ardekian
authors.forename: M
authors.initials: M
authors.lastname: Peleg
authors.forename: S
authors.initials: S
authors.lastname: Taicher
mesh_terms: D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D003374:Coumarins / Q000627:therapeutic use*; D003738:Dental Cements; D005260:Female; D005781:Gelatin Sponge, Absorbable; D006487:Hemostasis; D006489:Hemostatic Techniques; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D013515:Surgery, Oral; D014081:Tooth Extraction; D014148:Tranexamic Acid / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D003374:Coumarins; D003738:Dental Cements; D014148:Tranexamic Acid; C030123:coumarin