title: Propafenone pharmacokinetics and pharmacodynamics in patients with sustained ventricular tachycardia.
abstract: The myocardium accumulation and pharmacodynamics of propafenone were evaluated during intravenous infusion in 6 patients undergoing electrophysiologic study for evaluation of ventricular tachycardia. The myocardial accumulation of propafenone was delayed and resulted in nonlinear arterial concentration-effect relations.
authors.affiliation: Division of Cardiology, Foothills Hospital, Calgary, Alberta, Canada.
authors.forename: A M
authors.initials: AM
authors.lastname: Gillis
authors.forename: D G
authors.initials: DG
authors.lastname: Wyse
authors.forename: L B
authors.initials: LB
authors.lastname: Mitchell
authors.forename: H J
authors.initials: HJ
authors.lastname: Duff
mesh_terms: D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D011405:Propafenone / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D017180:Tachycardia, Ventricular / Q000097:blood*
chemical_list: D000889:Anti-Arrhythmia Agents; D011405:Propafenone