title: Ceftiofur hydrochloride: plasma and tissue distribution in swine following intramuscular administration at various doses.
abstract: Twelve mixed-breed swine (26.5-42.5 kg) received three daily intramuscular (i.m.) doses of 14C-ceftiofur hydrochloride. Three males and three females, received 6.76 +/- 0.83 mg of 14C-ceftiofur free acid equivalents (CFAE)/kg body weight (b.w.)/day, while the other group received 4.41 +/- 0.97 mg.CFAE/kg b.w./day. The swine were slaughtered 12 h following the last dose. Total dose accountability for the 6.76 mg dose was 91.44 +/- 16.11% (72.51% in urine; 12.63% in faeces). For the 4.41 mg dose, accountability was 100.35 +/- 20.45% (82.48% in urine; 12.85% in faeces). Within the tissues used for residue monitoring, the highest concentrations were observed in the kidneys (10.68 and 6.33 micrograms.CFAE/g for the 6.76 and 4.41 mg doses, respectively), followed by the injection sites, lungs, liver and muscle. In a separate study, twelve mix-breed swine (23.1-39.7 kg) received 14C-ceftiofur hydrochloride at 3.08 mg.CFAE/kg b.w. once daily for 3 days. Two males and two females were slaughtered at either 12, 72 or 120 h after the last dose. Total dose accountability for the 3.08 mg dose was > 83% (> 68% in urine; > 13% in faeces). In swine slaughtered 12 h after last dose, residue concentrations closest to the safe concentrations were observed in the kidneys (3.62 micrograms.CFAE/g), followed by the injection sites, lungs, liver and muscle.
authors.affiliation: Upjohn Company, Kalamazoo, MI 49001, USA.
authors.forename: M G
authors.initials: MG
authors.lastname: Beconi-Barker
authors.forename: R E
authors.initials: RE
authors.lastname: Hornish
authors.forename: T J
authors.initials: TJ
authors.lastname: Vidmar
authors.forename: K J
authors.initials: KJ
authors.lastname: Dame
authors.forename: S A
authors.initials: SA
authors.lastname: Brown
mesh_terms: D000818:Animals; D002250:Carbon Radioisotopes; D002511:Cephalosporins / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism / Q000652:urine; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000737:chemistry; D005260:Female; D007273:Injections, Intramuscular / Q000662:veterinary; D007553:Isotope Labeling; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D013552:Swine; D014018:Tissue Distribution
chemical_list: D002250:Carbon Radioisotopes; D002511:Cephalosporins; C053503:ceftiofur