High-affinity anti-DNA antibody parallels clinical course of immunoadsorption therapy for systemic lupus erythematosus.
Anti-DNA antibody, especially high-affinity anti-DNA antibody (ADNA), is thought to have an important role in the pathogenesis of lupus nephritis. In this study, ADNA which binds to double-stranded DNA under a high concentration of sodium chloride was measured in patients who had received immunoadsorption (IA) therapy with a dextran-sulfate column. Titers of high-affinity ADNA in the cases with renal dysfunction tended to be higher than in those without renal dysfunction. The change in the titer of high-affinity ADNA paralleled the clinical course. These findings suggest that measurement of high-affinity ADNA is useful for follow-up of the clinical course of patients who have undergone IA therapy.
Funauchi
M
M
Third Department of Internal Medicine, Kinki University School of Medicine, Osaka.
Ikoma
S
S
Enomoto
H
H
Ohno
M
M
Kinoshita
K
K
Horiuchi
A
A
Kurata
N
N
D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood* / Q000276:immunology; D000915:Antibody Affinity; D001327:Autoimmune Diseases / Q000097:blood / Q000276:immunology / Q000628:therapy*; D002846:Chromatography, Affinity; D004247:DNA / Q000276:immunology*; D016264:Dextran Sulfate; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007163:Immunosorbent Techniques; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology / Q000628:therapy*; D008181:Lupus Nephritis / Q000097:blood / Q000276:immunology / Q000628:therapy; D010956:Plasmapheresis
D000974:Antibodies, Antinuclear; D004247:DNA; D016264:Dextran Sulfate