[Cardiac impairment of elderly patients with diabetes mellitus as studied with non-invasive myocardial scintigraphy and signal-averaged electrocardiography].
In patients more than 65-year-old with diabetes mellitus, positive late potentials on signal-averaged electrocardiograms were more common than in normal subjects (p < 0.05). This suggests that aged patients with diabetes mellitus are at risk for micromyocardial impairment. Myocardial scintigraphy with 123I-metaiodobenzylguanidine showed abnormally low uptake, in parallel with the data on SA-ECG. Thus, both methods may be clinically useful ways to noninvasively reveal micromyocardial impairment in aged patients with diabetes mellitus. Moreover, trimetazidine hydrochloride may be effective as therapy for micromyocardial impairment: the uptake of 123I-metaiodobenzyl guanidine had increased in some patients when measured 1 year after administration of trimetazidine hydrochloride (18 mg/day) and the late potential changed from positive to negative.
Matsuki
T
T
Department of Internal Medicine, Okayama Red Cross General Hospital.
Adachi
N
N
Kondo
A
A
Hayashi
K
K
Matsuoka
T
T
Himei
H
H
D019797:3-Iodobenzylguanidine; D000368:Aged; D009202:Cardiomyopathies / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D048909:Diabetes Complications; D004562:Electrocardiography / Q000379:methods*; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008875:Middle Aged; D015899:Tomography, Emission-Computed, Single-Photon; D014292:Trimetazidine / Q000008:administration & dosage; D014665:Vasodilator Agents / Q000008:administration & dosage
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D014665:Vasodilator Agents; D019797:3-Iodobenzylguanidine; D014292:Trimetazidine