Effects of roxithromycin and erythromycin on interleukin 8-induced neutrophil recruitment and goblet cell secretion in guinea pig tracheas.
Inhaled interleukin 8 caused an increase in goblet cell secretion in guinea pig tracheas, which was accompanied by mucosal infiltration of neutrophils. These responses were inhibited by pretreatment with roxithromycin or erythromycin in a dose-dependent fashion. Macrolides may thus be a value in protecting against neutrophil-associated airway hypersecretion.
Tamaoki
J
J
First Department of Medicine, Tokyo Women's Medical College, Japan.
Nakata
J
J
Tagaya
E
E
Konno
K
K
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004917:Erythromycin / Q000494:pharmacology*; D006168:Guinea Pigs; D016209:Interleukin-8 / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects*; D015575:Roxithromycin / Q000494:pharmacology*; D014132:Trachea / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D016209:Interleukin-8; D015575:Roxithromycin; D004917:Erythromycin