Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q.
Metabotropic glutamate receptors (GRMs) are neurotransmitter receptors that respond to glutamate stimulations by activating GTP-binding proteins and modulating second-messenger cascades. Eight related GRMs have been identified to date. In this study, we have mapped GRM3 and GRM8 to human chromosome 7q21.1-q21.2 and 7q31.3-q32.1, respectively, using somatic cell hybrid and fluorescence in situ hybridization analysis. A yeast artificial chromosome contig was constructed surrounding the genes, allowing their location to be integrated into the genetic and physical map of chromosome 7.
Scherer
S W
SW
Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada.
Duvoisin
R M
RM
Kuhn
R
R
Heng
H H
HH
Belloni
E
E
Tsui
L C
LC
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D004247:DNA / Q000235:genetics; D015894:Genome, Human; D006801:Humans; D008969:Molecular Sequence Data; D051381:Rats; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics*
D018094:Receptors, Metabotropic Glutamate; D004247:DNA