Cutaneous T-cell lymphoma of the eyelid in a patient with acquired immunodeficiency syndrome.
Cutaneous T-cell lymphoma (CTCL) is significantly less common than B-cell lymphoma in patients with acquired immunodeficiency syndrome (AIDS). Periocular involvement by CTCL usually occurs in the setting of more widespread plaque or tumor-stage disease; therefore, CTCL localized solely to the periocular region is rare. We report the case of a 38-year-old Hispanic woman with AIDS and an enlarging tumor of the left upper eyelid. The clinical differential diagnosis included various infections and neoplasms. Examination of an incisional biopsy specimen revealed a dense infiltrate of atypical lymphocytes that labeled as T cells with use of the immunoperoxidase technique. The tumor subsequently regressed with local radiotherapy. Eyelid CTCL is reviewed and the differential diagnosis of eyelid lesions is reviewed.
Gibertson
E O
EO
University of California, San Diego, School of Medicine, Division of Dermatology 92103, USA.
Hunt
S J
SJ
Spellman
M C
MC
D017088:AIDS-Related Opportunistic Infections / Q000473:pathology; D000163:Acquired Immunodeficiency Syndrome / Q000473:pathology; D000328:Adult; D003937:Diagnosis, Differential; D005142:Eyelid Neoplasms / Q000473:pathology* / Q000532:radiotherapy; D005260:Female; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000473:pathology* / Q000532:radiotherapy; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology* / Q000532:radiotherapy