Clonidine in the management of asymmetrical gustatory facial sweating: an N-of-1 trial.
OBJECTIVE
To determine the efficacy of clonidine in the management of gustatory facial sweating (GFS) ipsilateral to an upper thoracic sympathectomy.


METHODS
Placebo-controlled N-of-1 trial.


METHODS
Tertiary care referral center.


METHODS
Clonidine patch that delivers 0.2mg/d.


METHODS
Daily episodes of GFS are recorded. The severity of GFS is graded as mild, moderate, or severe, and a daily GFS score is calculated.


RESULTS
Clonidine was shown to significantly decrease (p < .05) the incidence and frequency of gustatory facial sweating.
Nesathurai
S
S
Department of Rehabilitation Medicine, Boston University Medical Center Hospital, MA 02118-2393, USA.
Harvey
D T
DT
D000279:Administration, Cutaneous; D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D000328:Adult; D003000:Clonidine / Q000627:therapeutic use*; D005728:Ganglia, Sympathetic / Q000601:surgery*; D015171:Ganglionectomy / Q000009:adverse effects*; D006801:Humans; D008297:Male; D013547:Sweating, Gustatory / Q000188:drug therapy* / Q000209:etiology
D000316:Adrenergic alpha-Agonists; D003000:Clonidine