title: Acquired immune deficiency syndrome caused by hyperimmunity.
abstract: Normal immunocytes including T and B cells are equilibrated by a reciprocal attacking mechanism called a network. Continuous disequilibrium of this network results in general immunodeficiency with oligo- and polyclonal hyperimmunity, for example, T-cell activation due to spontaneous reticuloendotheliosis, paraneoplastic autoimmune syndromes, and human immunodeficiency virus infection. In these disorders, reciprocal self-reactivity, including autologous graft-versus-host reaction, plays a role in the immunodeficiency. A priori self-targeting immunity is a key mechanism to explain autoimmunity in the acquired immunodeficiency syndrome. In the treatment of the immunodeficiency due to hyperimmunity, I propose immunological suppression by agents and reconstitution of the network by bone-marrow transplantation.
authors.affiliation: Department of Orthopedic Surgery, Gunma University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Chigira
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000628:therapy; D000818:Animals; D017209:Apoptosis; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology*; D016026:Bone Marrow Transplantation; D006087:Graft vs Host Reaction; D006801:Humans; D008206:Lymphatic Diseases / Q000276:immunology; D018448:Models, Immunological; D010257:Paraneoplastic Syndromes / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*