Effect of serum from fertile and infertile patients with endometriosis on the development of mouse embryos.
OBJECTIVE
To evaluate the effect of serum from infertile and fertile patients with endometriosis on the development of 2-cell mouse embryos.


METHODS
Serum was obtained from 26 infertile patients and 8 fertile patients with endometriosis. Mouse embryo development in serum samples was compared using chi 2 analysis.


RESULTS
In the infertile group 23% of the embryos reached blastocyst stage, whereas 22 of the 26 samples were embryo toxic. In the fertile group significantly more embryos (45%) developed to blastocysts and only one serum samples was embryo toxic.


CONCLUSIONS
The embryo toxicity of serum samples from patients with endometriosis is related to the infertility associated with the disease and not with the disease per se.
Abu-Musa
A
A
Department of Obstetrics and Gynecology, American University of Beirut, Lebanon.
Takahashi
K
K
Kitao
M
M
D000818:Animals; D001681:Biological Assay; D001755:Blastocyst; D005314:Embryonic and Fetal Development; D004715:Endometriosis / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000097:blood* / Q000150:complications; D051379:Mice; D008813:Mice, Inbred ICR