title: Drosophila melanogaster genomic DNA sequence homologous to mammalian cytosine DNA-methyltransferase gene.
abstract: Using Southern blotting procedure we have shown that Drosophila genomic DNA hybridizes with 4423-bp C-terminal fragment of murine cytosine DNA-methyltransferase gene. Thus, the Drosophila genome has a sequence homologous to the mammalian cytosine DNA-methyltransferase gene. We assume that DNA methylation most likely responsible for strong CpG suppression in the Drosophila genome mainly was catalyzed by a cytosine DNA-methyltransferase that has since been lost.
authors.affiliation: Division of Nutritional Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
authors.forename: B F
authors.initials: BF
authors.lastname: Vanyushin
authors.forename: L A
authors.initials: LA
authors.lastname: Poirier
mesh_terms: D000818:Animals; D015257:DNA-Cytosine Methylases / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics*; D016678:Genome; D008322:Mammals / Q000235:genetics; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
chemical_list: C054926:DNA modification methylase AluI; D015257:DNA-Cytosine Methylases