Effects of antihypertensive drugs on maternal and fetal hemodynamics and uterine blood flow in pregnant goats--comparison of nicardipine and labetalol.
This study was designed to compare the effects of nicardipine (0.02 mg/kg) and labetalol (0.5 mg/kg) on the uterine blood flow and fetal circulation after intravenous administration in unanesthetized, chronically instrumented pregnant goats. Significant decreases in maternal blood pressure and uterine blood flow were observed in both groups. The maternal heart rate increased significantly after the injection of nicardipine, whereas this change was not observed after the labetalol injection. The fetal heart rate, blood pressure and acid-base status did not change after the injection of either nicardipine or labetalol. These observations in pregnant goats suggest that both nicardipine and labetalol might be useful drugs for the treatment of acutely hypertensive crises in pregnant patients.
Sakamoto
H
H
Department of Veterinary Medicine, Faculty of Agriculture, Kagoshima University, Japan.
Misumi
K
K
Matsuda
Y
Y
Ikenoue
T
T
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D005312:Fetal Blood; D005333:Fetus; D006041:Goats; D006339:Heart Rate / Q000187:drug effects; D006340:Heart Rate, Fetal / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D007741:Labetalol / Q000494:pharmacology*; D008431:Maternal-Fetal Exchange; D009529:Nicardipine / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D012039:Regional Blood Flow / Q000187:drug effects; D013997:Time Factors; D014599:Uterus / Q000098:blood supply*
D000959:Antihypertensive Agents; D002245:Carbon Dioxide; D009529:Nicardipine; D007741:Labetalol; D010100:Oxygen