Metal-independent putative superoxide dismutase mimics in chemistry, biology, and medicine.
The excessive generation of superoxide radicals O2-. with inadequate available defence provided by the enzyme superoxide dismutase (SOD) may result in the development and exacerbation of many of mankind's common illnesses. The native SOD proves too problematic to be used for the prevention and cure of such diseases. A number of metal-independent synthetic SOD mimics, based on organic nitroxides, have been tried as therapeutic interventions. Among the widely studied mimics, 2-ethyl-2,5,5-trimethyl-3-oxazolidinanyl, 2,2,6,6-tetramethyl-1-piperidimyloxy, nitrosoureas, and triazene derivatives have indicated promising results with possible future applications in chemistry, biology, and medicine.
Ahmad
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N
Industrial Toxicology Research Centre, M. G. Marg, Lucknow, 226001, India.
Misra
M
M
Husain
M M
MM
Srivastava
R C
RC
D003497:Cyclic N-Oxides / Q000627:therapeutic use*; D004358:Drug Therapy / Q000592:standards; D006801:Humans; D010080:Oxazoles / Q000627:therapeutic use*; D011315:Preventive Medicine / Q000592:standards; D017382:Reactive Oxygen Species; D013113:Spin Labels; D013329:Structure-Activity Relationship; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism*; D013812:Therapeutics / Q000592:standards
D003497:Cyclic N-Oxides; D010080:Oxazoles; D017382:Reactive Oxygen Species; D013113:Spin Labels; C034590:2-ethyl-2,5,5-trimethyl-3-oxazolidinoxyl; D013482:Superoxide Dismutase; C003959:TEMPO