[A study on the pathogenesis of hepatomegaly in patients with Crow-Fukase syndrome].
We studied pathogenesis of hepatomegaly in Crow-Fukase syndrome. Hepatocytes were isolated from BALB/c mice and cultured with serum or ascites of three patients with Crow-Fukase syndrome. After 24 hours culture, total number of hepatocytes was counted. The levels of human hepatocyte growth factor (h-HGF) in the serum were also measured. In the hepatocyte culture study, the numbers of hepatocytes after 24 hours cultured in the serum of two patients were significantly larger than those of the control group. When the hepatocytes were cultured with patients' serum after corticosteroid therapy, the survival numbers were markedly reduced. The serum levels of h-HGF in our three patients were 0.62, 0.52, 0.53 ng/ml respectively. They were all slightly higher than normal values (< or = 0.39 ng/ml). Our study indicates that in the serum or ascites of patients with Crow-Fukase syndrome, there may be some humoral factors other than h-HGF, which promote proliferation of hepatocyte or protect hepatocyte.
Fushimi
T
T
Department of Medicine (Neurology), Shinshu University School of Medicine.
Inoue
A
A
Koh
C S
CS
Yahikozawa
H
H
Yanagisawa
N
N
D000368:Aged; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D001202:Ascitic Fluid / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D017228:Hepatocyte Growth Factor / Q000378:metabolism / Q000502:physiology; D006529:Hepatomegaly / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008099:Liver / Q000166:cytology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D016878:POEMS Syndrome / Q000150:complications*; D011239:Prednisolone / Q000494:pharmacology / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D017228:Hepatocyte Growth Factor; D011239:Prednisolone