Effect of intermittent acid and pepsin exposure on burned esophageal mucosa.
OBJECTIVE
To determine if gastroesophageal reflux affects the healing of esophageal mucosa damaged by alkaline substances.


METHODS
In a rabbit model, the effects of intermittent acid and pepsin exposure (thereby mimicking gastroesophageal reflux) on post-caustic-burn esophageal mucosa were examined. Exposures were group I (n = 9), sodium hydroxide exposure alone; group II (n = 9), daily acid and pepsin exposure; and group III (n = 8), sodium hydroxide, then daily acid and pepsin exposure. After 3 weeks, the animals were killed and their esophagi examined.


RESULTS
Grossly, specimens in group II appeared normal; specimens in groups I and III were abnormal, displaying some scar tissue, but were not significantly different. Histologically, the differences between groups I and III approached significance. Increased numbers of intraepithelial eosinophils were seen in those specimens exposed to reflux.


CONCLUSIONS
Gastroesophageal reflux may retard the healing of injured esophageal mucosa and should be studied further in an effort to improve the care of patients who sustain alkaline esophageal burns.
Messner
A H
AH
Department of Otolaryngology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27157-1034, USA.
Browne
J D
JD
Geisinger
K R
KR
D000818:Animals; D002057:Burns, Chemical / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D002424:Caustics / Q000009:adverse effects; D004195:Disease Models, Animal; D004947:Esophagus / Q000473:pathology* / Q000503:physiopathology; D005744:Gastric Acid / Q000502:physiology*; D005764:Gastroesophageal Reflux / Q000503:physiopathology*; D010434:Pepsin A / Q000502:physiology*; D010865:Pilot Projects; D011817:Rabbits; D014945:Wound Healing / Q000502:physiology*
D002424:Caustics; D010434:Pepsin A