title: Effects of the adjuvant MPL + TDM on tumor challenge in the B16 mouse melanoma model.
abstract: Mice were injected three times at 2 week intervals with the adjuvant MPL + TDM or phosphate-buffered saline. Two weeks after the last injection, all mice were challenged subcutaneously with a tumorgenic dose of B16 tumor and observed for 40 days. The adjuvant hastened the time at which tumors appeared (P = 0.02).
authors.affiliation: Department of Biochemistry and Microbiology, College of Osteopathic Medicine, Oklahoma State University, Tulsa 74107, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Price
authors.forename: J M
authors.initials: JM
authors.lastname: McGee
authors.forename: M R
authors.initials: MR
authors.lastname: Patten
authors.forename: D
authors.initials: D
authors.lastname: Snyder
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D003311:Cord Factors / Q000494:pharmacology*; D008050:Lipid A / Q000031:analogs & derivatives* / Q000494:pharmacology; D008546:Melanoma, Experimental / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D014407:Tumor Cells, Cultured
chemical_list: D000276:Adjuvants, Immunologic; D003311:Cord Factors; D008050:Lipid A; C043399:6,6'-dicorynomycolyl trehalose; C048436:monophosphoryl lipid A