title: Oral fluconazole for vaginal candidiasis.
abstract: The recent surge of interest in fluconazole is due to its approval by the U.S. Food and Drug Administration for use as a single 150-mg oral dose in the treatment of vaginal candidiasis. Fluconazole is a triazole antifungal agent that acts primarily by inhibiting sterol synthesis in the fungal cell membrane. Recent studies have shown that a single dose of oral fluconazole is as effective as intravaginal antifungal agents. Many physicians and patients prefer this single-dose regimen because of its low rate of side effects, cost-effectiveness and ease of administration.
authors.affiliation: Hamot Family Practice Residency Program, Hamot Medical Center, Erie, Pennsylvania, USA.
authors.forename: P C
authors.initials: PC
authors.lastname: Desai
authors.forename: B A
authors.initials: BA
authors.lastname: Johnson
mesh_terms: D000284:Administration, Oral; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole