title: Aup1, a novel gene on mouse chromosome 6 and human chromosome 2p13.
abstract: We have cloned a novel mouse cDNA, Aup1, encoding a predicted protein of 410 amino acid residues. The 1.5-kb Aup1 transcript is ubiquitously expressed in mouse tissues. An evolutionary relationship to the Caenorhabditis elegans predicted protein F44b9.5 is indicated by the 35% identity and 53% conservation of the amino acid sequences. Nineteen related human ESTs spanning 80% of the protein have also been identified, with a predicted amino acid sequence identity of 86% between the human and the mouse proteins. The gene has been mapped to a conserved linkage group on human chromosome 2p13 and mouse Chromosome 6. Aup1 was eliminated as a candidate gene for two closely linked disorders, human LGMD2B and mouse mnd2.
authors.affiliation: Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, 48109-0618, USA.
authors.forename: W
authors.initials: W
authors.lastname: Jang
authors.forename: J S
authors.initials: JS
authors.lastname: Weber
authors.forename: R
authors.initials: R
authors.lastname: Bashir
authors.forename: K
authors.initials: K
authors.lastname: Bushby
authors.forename: M H
authors.initials: MH
authors.lastname: Meisler
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D006801:Humans; D008565:Membrane Proteins; D051379:Mice; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
chemical_list: C103007:AUP1 protein, mouse; D008565:Membrane Proteins; D011506:Proteins