title: Low-dose mitomycin C trabeculectomy in patients with advanced glaucoma.
abstract: OBJECTIVE
  The purpose of this study was to analyze the efficacy and safety of low-dose (0.2 mg/ml) intraoperative mitomycin C in primary trabeculectomy.
  
  
  METHODS
  Twenty-eight eyes of 28 patients with advanced primary open-angle glaucoma undergoing primary trabeculectomy were randomized to either mitomycin C (0.2 mg/ml) or saline solution intraoperatively for 3 min. Intraocular pressure was measured at 1 day; 1 week; 1, 3, and 6 months postoperatively; and at the final visit.
  
  
  RESULTS
  Mean follow-up was 17.0 +/- 5.6 months for the mitomycin C group and 15.7 +/- 5.1 months for the control group. Mean intraocular pressures were significantly lower in the treated group on the first postoperative day (p = 0.021), at the 6-month interval (p = 0.001), and at the final visit (p = 0.001). At the last follow-up examination, intraocular pressure was < or = 15 mm Hg in 12 (85.7%) of the mitomycin C-treated eyes and in four (28.6%) of the control eyes (p = 0.002). Life table analysis showed a significantly higher probability of intraocular pressure control in the mitomycin C group than in the control group (p = 0.0065). Choroidal effusion was observed in five (35.7%) treated eyes and two (14.3%) control eyes, whereas shallow anterior chamber were present in five (35.7%) treated eyes and one control eye (7.1%).
  
  
  CONCLUSIONS
  Despite inducing a higher short-term complication rate, low-dose mitomycin C may be an alternative in the treatment of eyes with advanced glaucomatous damage requiring low final intraocular pressures.
authors.affiliation: Department of Ophthalmology, University of Campinas (UNICAMP), Brazil.
authors.forename: V P
authors.initials: VP
authors.lastname: Costa
authors.forename: P E
authors.initials: PE
authors.lastname: Comegno
authors.forename: J P
authors.initials: JP
authors.lastname: Vasconcelos
authors.forename: R F
authors.initials: RF
authors.lastname: Malta
authors.forename: N K
authors.initials: NK
authors.lastname: José
mesh_terms: D000368:Aged; D000477:Alkylating Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000009:adverse effects / Q000627:therapeutic use*; D009883:Ophthalmic Solutions; D011183:Postoperative Complications; D016019:Survival Analysis; D014130:Trabeculectomy
chemical_list: D000477:Alkylating Agents; D009883:Ophthalmic Solutions; D016685:Mitomycin