title: Thermoregulation and the pathogenesis of fever.
abstract: Infections, trauma, inflammatory processes, and some malignant diseases induce a constellation of host responses that are collectively referred to as the "acute-phase response." Elevation of core temperature is certainly part of the acute-phase response, and cytokines that raise core temperature in pathologic states are some of the same cytokines that account for other manifestations of the acute-phase response. This article examines fever as a part of the acute-phase reaction and the role of cytokines in thermoregulation.
authors.affiliation: Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Dinarello
mesh_terms: D000210:Acute-Phase Reaction / Q000209:etiology*; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology; D001833:Body Temperature Regulation; D002097:C-Reactive Protein / Q000032:analysis; D016207:Cytokines / Q000235:genetics / Q000502:physiology; D005334:Fever / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D007239:Infections / Q000150:complications; D007249:Inflammation / Q000150:complications; D009369:Neoplasms / Q000150:complications; D011749:Pyrogens / Q000502:physiology; D014947:Wounds and Injuries / Q000150:complications
chemical_list: D018712:Analgesics, Non-Narcotic; D016207:Cytokines; D011749:Pyrogens; D002097:C-Reactive Protein