DNA condensation.
Recent progress in our understanding of DNA condensation includes the observation of the collapse of single DNA molecules, greater insights into the intermolecular forces driving condensation, the recognition of helix-structure perturbation in condensed DNA, and the increasing recognition of the likely biological consequences of condensation. DNA condensed with cationic liposomes is an efficient agent for the transfection of eukaryotic cells, with considerable potential interest for gene therapy.
Bloomfield
V A
VA
Department of Biochemistry, University of Minnesota, St. Paul 55108, USA. victor@biosci.cbs.umn.edu
D000438:Alcohols / Q000378:metabolism; D002152:Calorimetry, Differential Scanning; D002412:Cations / Q000378:metabolism; D004247:DNA / Q000737:chemistry*; D008081:Liposomes / Q000378:metabolism; D009690:Nucleic Acid Conformation; D011092:Polyethylene Glycols / Q000378:metabolism
D000438:Alcohols; D002412:Cations; D008081:Liposomes; D011092:Polyethylene Glycols; D004247:DNA