title: Cutaneous mucor infection treated with wide excision in two children who underwent marrow transplantation.
abstract: Cutaneous mucor infection developed in two children who had undergone bone marrow transplantation for treatment of leukemia. One infection occurred before transplantation, and the other occurred during the period of profound neutropenia after transplantation. Both children were treated with an extensive wide excision of the infected area, and there was no evidence of mucor along the resected edges of tissue. Both patients received extensive treatment with either amphotericin (case 1) or amphotericin and itraconazole (case 2). These two cases represent aggressive management of cutaneous mucor infections, which is believed to be required for the successful completion of a marrow transplantation procedure.
authors.affiliation: Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City 52242, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Trigg
authors.forename: M A
authors.initials: MA
authors.lastname: Comito
authors.forename: S L
authors.initials: SL
authors.lastname: Rumelhart
mesh_terms: D000293:Adolescent; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002648:Child; D003881:Dermatomycoses / Q000601:surgery*; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage / Q000627:therapeutic use; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008297:Male; D009091:Mucormycosis / Q000601:surgery*; D009503:Neutropenia / Q000150:complications; D009894:Opportunistic Infections / Q000601:surgery; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy; D012233:Rhizopus / Q000302:isolation & purification
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B