title: Influence of smoking in the glutathione-S-transferase M1 deficiency--associated risk for squamous cell carcinoma of the bladder in schistosomiasis patients in Egypt.
abstract: In this study we show an effect of the glutathione-S-transferase M1 (GSTM1) null phenotype on the risk for squamous cell carcinoma (SCC) of the bladder among male smokers in Egypt, with an adjusted odds ratio of 4.8 (95% confidence interval: 1.06-21.77). However, no overall effect of the GSTM1 null phenotype on the risk for bladder SCC was observed.
authors.affiliation: Institut de Salut Pública, University of Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Lafuente
authors.forename: M M
authors.initials: MM
authors.lastname: Zakahary
authors.forename: M A
authors.initials: MA
authors.lastname: el-Aziz
authors.forename: C
authors.initials: C
authors.lastname: Ascaso
authors.forename: M J
authors.initials: MJ
authors.lastname: Lafuente
authors.forename: M
authors.initials: M
authors.lastname: Trias
authors.forename: P
authors.initials: P
authors.lastname: Carretero
mesh_terms: D000328:Adult; D000367:Age Factors; D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D016009:Chi-Square Distribution; D004198:Disease Susceptibility; D004534:Egypt / Q000453:epidemiology; D005260:Female; D005982:Glutathione Transferase / Q000172:deficiency* / Q000235:genetics; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D012307:Risk Factors; D012552:Schistosomiasis / Q000150:complications* / Q000473:pathology; D012907:Smoking / Q000009:adverse effects*; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology / Q000209:etiology*
chemical_list: D005982:Glutathione Transferase