title: Common variable immunodeficiency in a patient with systemic lupus erythematosus.
abstract: This report describes a young girl who developed systemic lupus erythematosus at the age of 11. In the years thereafter a conversion took place from hypergammaglobulinemia to hypogammaglobulinemia with the absence of circulating and bone marrow B-cells. Some aspects of the aetiopathogenesis of common variable immunodeficiency are discussed.
authors.affiliation: Department of Rheumatology, Dr. Daniel den Hoed Clinic, Rotterdam, The Netherlands.
authors.forename: A J
authors.initials: AJ
authors.lastname: Swaak
authors.forename: H G
authors.initials: HG
authors.lastname: van den Brink
mesh_terms: D000361:Agammaglobulinemia / Q000150:complications; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000209:etiology / Q000276:immunology; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications; D007136:Immunoglobulins / Q000097:blood; D066298:In Vitro Techniques; D015850:Interleukin-6 / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: D007136:Immunoglobulins; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha