title: Application of stripping voltammetry to trace lead analysis in intermediates and final products of syntheses of pharmaceuticals.
abstract: Applications of differential pulse anodic stripping voltammetry using a new pen-type renewed hanging mercury electrode have been investigated for trace analysis of lead in pharmaceutical substances and intermediates of their syntheses, such as procaine hydrochloride, 4-aminobenzoic acid, methyl 4-aminobenzoate, 2-(4-chlor-3-aminobenzoyl) benzoic acid, benzyl 2-naphthyl ether, 5-aminoisophthalic acid, 3-aminobenzoic acid, 5-hydroxyisophthalic acid, and N, N'-dibenzylethylenediamine diacetate. Samples were dissolved in 1 M HCI or 1 M NaOH and the electrochemical scan was carried out. No sample mineralization was necessary. The method showed a good linearity up to 50-100 ppm Pb with a detection limit less than 100 ppb. The results agreed well, but were more precise than those obtained by atomic absorption spectrometry using air/acetylene flame atomisation.
authors.affiliation: Department of Analytical Chemistry, University of Pardubice, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Pravda
authors.forename: K
authors.initials: K
authors.lastname: Vytras
mesh_terms: D010129:4-Aminobenzoic Acid / Q000032:analysis / Q000737:chemistry; D062365:Aminobenzoates / Q000032:analysis / Q000737:chemistry; D004563:Electrochemistry; D004566:Electrodes; D004791:Enzyme Inhibitors / Q000032:analysis / Q000737:chemistry; D004987:Ethers / Q000032:analysis / Q000737:chemistry; D007854:Lead / Q000032:analysis*; D008628:Mercury / Q000737:chemistry; D010795:Phthalic Acids / Q000032:analysis / Q000737:chemistry; D011343:Procaine / Q000032:analysis / Q000737:chemistry; D015203:Reproducibility of Results; D013054:Spectrophotometry, Atomic; D062368:meta-Aminobenzoates; D062366:para-Aminobenzoates
chemical_list: D062365:Aminobenzoates; D004791:Enzyme Inhibitors; D004987:Ethers; D010795:Phthalic Acids; D062368:meta-Aminobenzoates; D062366:para-Aminobenzoates; D007854:Lead; D011343:Procaine; C102689:benzyl 2-naphthyl ether; C037880:5-hydroxyisophthalic acid; C067182:methyl 4-aminobenzoate; C102688:5-aminoisophthalic acid; D008628:Mercury; C044855:3-aminobenzoic acid; D010129:4-Aminobenzoic Acid