title: Change of refraction in premature infants after cryotherapy for retinopathy of prematurity between the age of six months and three years.
abstract: To investigate the chronological change of refraction in premature infants after cryotherapy for retinopathy of prematurity (ROP), cycloplegic refractions had been performed at 6 months and 3 years after term in premature infants who underwent cryotherapy for ROP. The changes of refractions between the two study ages were evaluated not only in the total cryo-treated eyes, but also in the subdivided groups according to the posterior pole appearances. In the total 61 eyes of 32 premature infants, mean spherical equivalents were -4.05D vs. -5.94D (6 months vs. 3 years) (p = 0.0001). In the normal posterior pole group (48 eyes), mean spherical equivalents were -3.45D vs. -5.68D (6 months vs. 3 years) (p = 0.0000), and in the abnormal posterior pole group (13 eyes), -6.28D vs. -6.86D (6 months vs. 3 years) (p = 0.6496). These results mean that there is a myopic progressive change between 6 months and 3 years after term in the cryo-treated eyes for acute ROP and it is more evident in the eyes with normal posterior pole.
authors.affiliation: Department of Ophthalmology, College of Medicine, Seoul National University, Korea.
authors.forename: S I
authors.initials: SI
authors.lastname: Khwarg
authors.forename: H G
authors.initials: HG
authors.lastname: Yu
authors.forename: Y S
authors.initials: YS
authors.lastname: Yu
mesh_terms: D000208:Acute Disease; D002675:Child, Preschool; D003452:Cryosurgery / Q000009:adverse effects*; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D009216:Myopia / Q000209:etiology* / Q000503:physiopathology; D012029:Refraction, Ocular; D012178:Retinopathy of Prematurity / Q000503:physiopathology / Q000601:surgery*