title: Possible pathogenic role for Sporothrix cyanescens isolated from a lung lesion in a heart transplant patient.
abstract: Sporothrix cyanescens is a fungus rarely isolated from human specimens. Its pathogenic role has never been demonstrated but has been postulated on the basis of its occurrence in normally sterile body sites, its isolation from debilitated individuals and its thermotolerance. A first case of nodular pulmonary lesions developing in an immunosuppressed, heart transplant patient is reported. Sporothrix cyanescens was isolated from a fine needle lung biopsy. The patient failed to respond to itraconazole therapy, whereas he was successfully treated with amphotericin B.
authors.affiliation: Division of Infectious Diseases, Ospedali Riuniti, Bergamo, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Tambini
authors.forename: C
authors.initials: C
authors.lastname: Farina
authors.forename: R
authors.initials: R
authors.lastname: Fiocchi
authors.forename: B
authors.initials: B
authors.lastname: Dupont
authors.forename: E
authors.initials: E
authors.lastname: Guého
authors.forename: G
authors.initials: G
authors.lastname: Delvecchio
authors.forename: F
authors.initials: F
authors.lastname: Mamprin
authors.forename: G
authors.initials: G
authors.lastname: Gavazzeni
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D016027:Heart Transplantation; D006801:Humans; D016867:Immunocompromised Host; D008172:Lung Diseases, Fungal / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology*; D011859:Radiography; D013175:Sporothrix / Q000302:isolation & purification*
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B