Beta 1-adrenoceptor autoimmunity in cardiomyopathy.
A growing body of studies have confirmed that autoantibodies against beta 1-adrenoceptors are present in different types of cardiomyopathy. This suggests that they play a role in the pathophysiology of the disease. This article will review the data indicating the presence of anti-beta 1-adrenoceptor autoantibodies in cardiomyopathy. It will focus upon their structural and functional properties which could explain their possible role in the induction and development of cardiomyopathic diseases.
Magnusson
Y
Y
Wallenberg Laboratory, Sahlgren's Hospital, University of Gothenburg, Sweden.
Hjalmarson
A
A
Hoebeke
J
J
D001323:Autoantibodies / Q000032:analysis / Q000096:biosynthesis*; D002311:Cardiomyopathy, Dilated / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D011943:Receptors, Adrenergic, beta / Q000032:analysis / Q000096:biosynthesis*
D001323:Autoantibodies; D011943:Receptors, Adrenergic, beta