[The role of free radical processes in the development of autosensitization in ischemic heart disease].
Derangement in freeradical processes (FRP) and lipid metabolism is known to occur in ischemic heart disease. Since autoimmune component appear to play an important role in the pathogenesis of IHD, the contributers to the article studied the state of freeradical processes in IHD patients during development of autosensibilization. A total of 42 patients with unstable angina and 8 essentially healthy subjects were examined. The blood level of FRP, antioxidant protection were determined using chemiluminometry technique. The blood serum content of free cholesterol and phospholipid fatty acid composition were evaluated by gas-liquid chromatography, the T- and B-lymphocyte functional status by fluorescent probing with acridine orange. The level of autoantibodies was determined as recommended by Boiden. The lymphocyte circulating population functional activity was found to be related to the state of FRP, antioxidant protection and the blood serum lipidic complex composition.
Afonina
G B
GB
Girina
O N
ON
Briuzgina
T S
TS
Mostbauér
G V
GV
Rusin
E V
EV
Garkavaia
E G
EG
Bordonos
V G
VG
D000975:Antioxidants; D001327:Autoimmune Diseases / Q000097:blood / Q000209:etiology*; D015551:Autoimmunity; D005609:Free Radicals / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood; D008214:Lymphocytes / Q000276:immunology; D017202:Myocardial Ischemia / Q000097:blood / Q000209:etiology*
D000975:Antioxidants; D005609:Free Radicals; D008055:Lipids