Influence of opioid peptides on the priming action of estrogen on lordosis in ovariectomized rats.
Lordosis in response to male mounting in estrogen-progesterone primed ovariectomized rats was facilitated by beta-endorphin or metenkephalin but inhibited by leu-enkephalin if the peptides were injected into third ventricle at the time of estrogen-priming. It is suggested that opioidergic systems modulate the activation of the estrogen-dependent brain functions that control lordosis.
Torii
M
M
Laboratory for Environmental Bioregulation, Faculty of Engineering, Kyushu Institute of Technology, Fukuoka, Japan.
Kubo
K
K
Sasaki
T
T
D000818:Animals; D004743:Enkephalin, Leucine / Q000494:pharmacology; D004744:Enkephalin, Methionine / Q000494:pharmacology; D004967:Estrogens / Q000502:physiology*; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D018847:Opioid Peptides / Q000502:physiology*; D010052:Ovariectomy; D011187:Posture / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012726:Sexual Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D001615:beta-Endorphin / Q000494:pharmacology
D004967:Estrogens; D018847:Opioid Peptides; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine; D001615:beta-Endorphin