title: Signal transduction as a therapeutic target.
authors.affiliation: Signal Transduction and Prevention Unit, National Cancer Institute, Bethesda, MD 20892-1500, USA.
authors.forename: R
authors.initials: R
authors.lastname: Alessandro
authors.forename: J
authors.initials: J
authors.lastname: Spoonster
authors.forename: R P
authors.initials: RP
authors.lastname: Wersto
authors.forename: E C
authors.initials: EC
authors.lastname: Kohn
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002118:Calcium / Q000502:physiology; D002121:Calcium Channel Blockers / Q000494:pharmacology / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D019204:GTP-Binding Proteins / Q000037:antagonists & inhibitors / Q000502:physiology; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D015640:Ion Channel Gating / Q000187:drug effects; D007473:Ion Channels / Q000187:drug effects; D051379:Mice; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000502:physiology; D009369:Neoplasms / Q000503:physiopathology / Q000628:therapy*; D009857:Oncogenes; D019869:Phosphatidylinositol 3-Kinases; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D010727:Phosphoric Diester Hydrolases / Q000502:physiology; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000037:antagonists & inhibitors / Q000502:physiology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000502:physiology; D016283:Proto-Oncogene Proteins p21(ras) / Q000037:antagonists & inhibitors / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects; D014230:Triazoles / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D002121:Calcium Channel Blockers; D006133:Growth Substances; D007473:Ion Channels; D009363:Neoplasm Proteins; D014230:Triazoles; C062058:carboxyamido-triazole; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor); D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases; D011493:Protein Kinase C; D010727:Phosphoric Diester Hydrolases; D019204:GTP-Binding Proteins; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras); D043265:Phosphatidylinositol Diacylglycerol-Lyase; D002118:Calcium