title: Mucosal permeability of ileal and colonic reservoirs for urine.
abstract: OBJECTIVE
  To evaluate the intestinal mucosal permeability in continent reservoirs for urine.
  
  
  METHODS
  The mucosal permeability in continent urinary reservoirs, constructed either from an ileal or a colonic segment (six patients each), was assessed by analysing serial samples of plasma, after instilling the reservoir with 51Cr-ethylene diaminetetra-acetic acid (51Cr-EDTA), and serum, after instillation with polyethylene glycol (PEG 400).
  
  
  RESULTS
  There was no or negligible permeation of 51Cr-EDTA and PEG 400 in either type of reservoir, as there was no significant increase of the markers in plasma and serum, respectively.
  
  
  CONCLUSIONS
  The intestinal barrier to medium-sized hydrophilic molecules seems intact in continent urinary reservoirs. The lack of significant permeation of 51Cr-EDTA confirms the usefulness of a single injection of 51Cr-EDTA for the determination of glomerular filtration rate in patients with intestinal urinary diversion.
authors.affiliation: Department of Urology, University Hospital, Lund, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Davidsson
authors.forename: S
authors.initials: S
authors.lastname: Akerlund
authors.forename: T
authors.initials: T
authors.lastname: White
authors.forename: G
authors.initials: G
authors.lastname: Olaisson
authors.forename: W
authors.initials: W
authors.lastname: Månsson
mesh_terms: D003106:Colon / Q000378:metabolism / Q000637:transplantation; D004492:Edetic Acid / Q000493:pharmacokinetics; D005500:Follow-Up Studies; D006801:Humans; D007082:Ileum / Q000378:metabolism / Q000637:transplantation; D007413:Intestinal Mucosa / Q000378:metabolism*; D010539:Permeability; D016476:Urinary Reservoirs, Continent
chemical_list: D004492:Edetic Acid