Liver metastases from gastric carcinoma: report of a patient treated with adoptive immunotherapy (tumor-infiltrating lymphocytes plus interleukin-2 and subsequently local-regional lymphokine-activated killer cells plus interleukin-2).
A 37-year-old patient with liver metastases from gastric cancer was treated with a double adoptive immunotherapy regimen comprising tumor-infiltrating lymphocytes plus interleukin-2 and subsequently local-regional lymphokine-activated killer cells plus interleukin-2 because of an extremely high in vitro cytotoxic specific activity on established gastric cancer cell lines. The necrosis verified in the center of the hepatic metastasis would appear to demonstrate treatment efficacy, but no clinical response was seen. In vitro cytotoxicity data alone are insufficient to predict the clinical efficacy of adoptive immunotherapy.
Fabbri
L
L
Istituto Oncologico Romagnolo, Forlì, Italy.
Ridolfi
R
R
Riccobon
A
A
Maltoni
R
R
Flamini
E
E
Fedriga
R
R
Flamigni
A
A
Migliori
G
G
Ortolani
F
F
Calzolari
F
F
D000328:Adult; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D007376:Interleukin-2 / Q000627:therapeutic use*; D015979:Killer Cells, Lymphokine-Activated; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D016246:Lymphocytes, Tumor-Infiltrating; D008297:Male; D013274:Stomach Neoplasms / Q000473:pathology*
D007376:Interleukin-2