Characteristics of the mouse genomic histamine H1 receptor gene.
We report here the molecular cloning of a mouse histamine H1 receptor gene. The protein deduced from the nucleotide sequence is composed of 488 amino acid residues with characteristic properties of GTP binding protein-coupled receptors. Our results suggest that the mouse histamine H1 receptor gene is a single locus, and no related sequences were detected. Interspecific backcross analysis indicated that the mouse histamine H1 receptor gene (Hrh1) is located in the central region of mouse Chromosome 6 linked to microphthalmia (Mitfmi), ras-related fibrosarcoma oncogene 1 (Raf1), and ret proto-oncogene (Ret) in a region of homology with human chromosome 3p.
Inoue
I
I
Department of Molecular Immunology, Kyushu University 3-1-1, Higashi-ku, Fukuoka, 812, Japan.
Taniuchi
I
I
Kitamura
D
D
Jenkins
N A
NA
Gilbert
D J
DJ
Copeland
N G
NG
Watanabe
T
T
D000595:Amino Acid Sequence; D000818:Animals; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D003433:Crosses, Genetic; D019204:GTP-Binding Proteins; D018628:Gene Dosage; D005796:Genes / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009115:Muridae; D012150:Polymorphism, Restriction Fragment Length; D000090063:Proto-Oncogene Mas; D011969:Receptors, Histamine H1 / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011969:Receptors, Histamine H1; D019204:GTP-Binding Proteins