Membrane-bound tyrosine aminopeptidase activities in the rat brain throughout the estrous cycle.
Puromycin sensitive and insensitive membrane-bound aminopeptidase activity levels during the estrous cycle in several brain areas have been described in this research. We have found the highest aminopeptidase M activity levels during the proetrous stage in the hypothalamus, the amygdala and the pituitary gland. Since this enzyme has been involved in opioid peptide metabolism, it is suggested that aminopeptidase M could play a part in the decrease in the inhibitory influence of the endogenous opioids peptides that participate in the LH surge.
de Gandarias
J M
JM
Department of Physiology, Medical School, University of the Basque Country, Bilbao, Spain.
Irazusta
J
J
Fernández
D
D
Gallego
M
M
Silió
M
M
Casis
L
L
D000626:Aminopeptidases / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000502:physiology; D002462:Cell Membrane / Q000201:enzymology; D004971:Estrus; D005260:Female; D011691:Puromycin / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
D011691:Puromycin; D000626:Aminopeptidases