title: Replacement of the ascending aorta with composite valve grafts: long term results.
abstract: OBJECTIVE
  Long term survival after replacement of the aortic root is improving. The most common cause of late death is progression of disease in the remaining aorta (dissection or atherosclerosis). The purpose of this study was to review our clinical experience with composite graft replacement of the aortic root with special reference to long term results.
  
  
  METHODS
  One hundred twenty-six patients (mean age: 53 years) with different pathologies of the ascending aorta underwent aortic root replacement with a composite-graft prosthesis over a 12-year period. Twenty-three patients had previously undergone cardiovascular surgery. The surgical technique included resection of the ascending aorta with the aortic valve and end-to-side anastomosis between full-thickness buttons of the aortic wall with the coronary ostia and the graft. One or more associated cardiovascular procedures were performed in 24 cases. Long term follow up to July 1995 is complete. Uni- and multivariate analysis were performed to identify risk-factors for early and late mortality and reoperation.
  
  
  RESULTS
  Twenty-three patients died during the first 30 days (18%). Sixteen of them had aortic dissection. The most common cause of early death was heart failure. Twenty-three patients died during the follow up time with heart failure, again, being the most common cause of death. Thirteen late reoperations on the composite-graft or the remaining aorta were performed in 12 patients, six of whom had Marfan's syndrome. The 30-day mortality at reoperation was 30%.
  
  
  CONCLUSIONS
  This surgical option offers good long term results with a five-year actuarial survival of 67% or 75% when the 30-day mortality is excluded. Careful follow up of patients with Marfan's syndrome and/or aortic dissection is mandatory to increase the long term survival.
authors.affiliation: Department of Cardiothoracic Surgery, Sahlgren's Hospital, Göteborg, Sweden.
authors.forename: V
authors.initials: V
authors.lastname: Lepore
authors.forename: S
authors.initials: S
authors.lastname: Larsson
authors.forename: M
authors.initials: M
authors.lastname: Bugge
authors.forename: V
authors.initials: V
authors.lastname: Mantovani
authors.forename: T
authors.initials: T
authors.lastname: Karlsson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000714:Anastomosis, Surgical / Q000379:methods / Q000401:mortality; D001011:Aorta / Q000601:surgery*; D001018:Aortic Diseases / Q000150:complications / Q000401:mortality / Q000601:surgery*; D001021:Aortic Valve / Q000601:surgery*; D001807:Blood Vessel Prosthesis / Q000379:methods* / Q000401:mortality; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis / Q000379:methods* / Q000401:mortality; D006801:Humans; D008297:Male; D008382:Marfan Syndrome / Q000150:complications / Q000401:mortality / Q000601:surgery; D008875:Middle Aged; D015999:Multivariate Analysis; D012086:Reoperation / Q000401:mortality; D012189:Retrospective Studies; D015996:Survival Rate