Coronary arteriography with an oxygenated contrast medium: cardiac effects in dogs with and without acute ischemic heart failure.
OBJECTIVE
We investigated the possible cardiac effects of oxygen addition to contrast media (CM) during coronary arteriography in dogs that did and did not have ischemic heart failure.


METHODS
Acute ischemic heart failure was induced by injecting small plastic microspheres into the left coronary artery of 18 dogs. Hemodynamic and electrophysiologic measurements were performed during a single injection before and during heart failure and during a single injection and five rapidly repeated CM injections during heart failure. Iohexol supplemented with electrolytes (iohexol + electrolytes = IPE), oxygenated IPE (IPE+O), Ringer acetate, and oxygenated Ringer acetate were injected into the left coronary artery.


RESULTS
Single injections of IPE and IPE+O induced small hemodynamic and electrophysiologic effects. However, repeated injections of IPE and IPE+O increased left ventricular inotropy (maximum value of the first derivative of the left ventricular pressure) by 36% and 39%, reduced heart rate by 7% (for both), and lengthened QTc time (corrected QT interval) by 39 and 38 msec, respectively. A comparison of IPE and IPE+O revealed no statistically significant differences.


CONCLUSIONS
Although electrolyte addition to nonionic CM may reduce the risk of cardiac complications during coronary arteriography, oxygenation does not seem to significantly further reduce this risk.
Pedersen
H K
HK
Department of Radiology, University of Tromsø, Norway.
Jacobsen
E A
EA
Refsum
H
H
D000818:Animals; D003287:Contrast Media; D017023:Coronary Angiography / Q000379:methods*; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004285:Dogs; D004573:Electrolytes; D006333:Heart Failure / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology; D007269:Injections, Intra-Arterial; D007472:Iohexol; D007552:Isotonic Solutions; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology; D010100:Oxygen; D000077325:Ringer's Lactate
D003287:Contrast Media; D004573:Electrolytes; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D007472:Iohexol; D010100:Oxygen