A limited genomic region contains the human REG and REG-related genes.
A glycoprotein expressed in exocrine pancreas (where it has been called lithostathine) and endocrine pancreas (where it has been called the regeneration protein) is encoded by a gene (REG) which maps to 2p12. A REG-related sequence (REGL) is also located in 2p12 and expressed in the pancreas. Here we describe the physical mapping of these genes within a 100-kb genomic region. A YAC clone was converted into an ordered cosmid contig. We constructed a restriction map of the cosmid contig and localized the loci corresponding to the genes. A third REG-related sequence also maps to this region. Although this sequence was previously described as a pseudogene, we show here that it is also expressed in the pancreas.
Bartoli
C
C
INSERM U 406, Marseille, France.
Dagorn
J C
JC
Fontes
M
M
Bergé-Lefranc
J L
JL
D001483:Base Sequence; D002135:Calcium-Binding Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast / Q000235:genetics; D003360:Cosmids; D017931:DNA Primers; D015870:Gene Expression; D006801:Humans; D051847:Lithostathine; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins; D011544:Pseudogenes
D002135:Calcium-Binding Proteins; D017931:DNA Primers; D051847:Lithostathine; D009419:Nerve Tissue Proteins; C497617:REG1A protein, human