Gastrin levels in mothers and neonates at delivery in various perinatal conditions.
BACKGROUND
This study was designed to assess the variations of gastrin (Ga) serum levels in mothers and newborns at birth in some perinatal disorders.


METHODS
Ga levels were measured by RIA in maternal serum, amniotic fluid and cord sera of newborns in 55 cases with the following conditions: normal pregnancy and eutocic vaginal delivery (n = 8), repeat cesarean section (n = 10), and cardiotogographic register suggestive of fetal compromise (n = 15), cephalopelvic disproportion (n = 8), preeclampsia (n = 7) and postdate pregnancy (n = 7). Statistical analysis was performed by Mann-Whitney U test.


RESULTS
Ga levels in cord sera of newborn and amniotic fluid in normal pregnancy and eutocic delivery were significantly higher (p < 0.02 and p < 0.01, respectively) than those found in patients with repeat cesarean operation. Serum Ga concentrations in women with postterm pregnancy were significantly higher (p < 0.02) than in women with prior cesarean section. Ga levels in amniotic fluid samples in the presence of suspected fetal compromise and postdate pregnancy were significantly higher (p < 0.001) than those observed in women who had repeat cesarean operation.


CONCLUSIONS
Vaginal delivery and perinatal pathology may induce hypergastrinemia in both mother and neonate at birth.
Morán
C
C
Research Unit of Reproductive Medicine, Hospital Luis Castelazo Ayala, Mexico.
Carranza-Lira
S
S
Ochoa
R
R
Martínez
J C
JC
Herrera
M
M
Fonseca
E
E
Zárate
A
A
D000328:Adult; D000653:Amniotic Fluid / Q000737:chemistry*; D002585:Cesarean Section; D036861:Delivery, Obstetric; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005755:Gastrins / Q000032:analysis* / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D007746:Labor Presentation; D011247:Pregnancy
D005755:Gastrins