The two-way paradigm of transplantation immunology.
The events following organ transplantation require a reciprocal cell interaction which includes both the conventional host-versus-graft reaction and a graft-versus-host component. With all successful transplantation, both graft and recipient become genetic composites. Where donors were available, chimerism has been confirmed in 30-year kidney-recipient survivors, as well as in several liver and lung recipients. A majority of liver recipients have been able to acquire an immunosuppressant-free state after 10-year survival. Animal models suggest that donor-derived cells may exert a tolerogenic effect.
Rao
A S
AS
Pittsburgh Transplant Institute, University of Pittsburgh Medical Center, Pennsylvania 15213, USA.
Starzl
T E
TE
Demetris
A J
AJ
Trucco
M
M
Thomson
A
A
Qian
S
S
Murase
N
N
Fung
J J
JJ
D000818:Animals; D006085:Graft Survival / Q000276:immunology; D006086:Graft vs Host Disease / Q000276:immunology; D006789:Host vs Graft Reaction / Q000276:immunology; D006801:Humans; D018183:Transplantation Chimera; D014181:Transplantation Immunology