title: Long term follow-up of children with mixed connective tissue disease.
abstract: Mixed connective tissue disease (MCTD) is characterized by features of more than one of the rheumatic disorders with antinuclear antibodies in a speckled pattern and with antibodies to nuclear ribonucleoprotein (nRNP). MCTD is uncommon in children and long-term follow-up studies in children are infrequently reported. A retrospective review of clinical experience at five pediatric rheumatology centers provided 11 patients who met the following inclusion criteria: (1) Kasukawa's criteria for MCTD1; (2) presentation younger than 18th birthday; (3) greater than five years of follow-up; (4) completion of data collection form. The widely varying outcomes of these 11 children with MCTD on long-term follow-up may lend doubt that this is a unique and distinctive rheumatologic disorder.
authors.affiliation: Shriners Hospital, Lexington, Kentucky 40502, USA.
authors.forename: R
authors.initials: R
authors.lastname: Mier
authors.forename: B
authors.initials: B
authors.lastname: Ansell
authors.forename: M A
authors.initials: MA
authors.lastname: Hall
authors.forename: N
authors.initials: N
authors.lastname: Hasson
authors.forename: J
authors.initials: J
authors.lastname: Levinson
authors.forename: D
authors.initials: D
authors.lastname: Lovell
authors.forename: M
authors.initials: M
authors.lastname: Passo
authors.forename: R
authors.initials: R
authors.lastname: Rennebohm
authors.forename: P
authors.initials: P
authors.lastname: Woo
mesh_terms: D000293:Adolescent; D000974:Antibodies, Antinuclear / Q000097:blood; D001324:Autoantigens; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006680:HLA Antigens; D006801:Humans; D008297:Male; D008947:Mixed Connective Tissue Disease / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D011379:Prognosis; D012189:Retrospective Studies; D012261:Ribonucleoproteins / Q000276:immunology; D055517:snRNP Core Proteins
chemical_list: D000974:Antibodies, Antinuclear; D001324:Autoantigens; D006680:HLA Antigens; D012261:Ribonucleoproteins; D055517:snRNP Core Proteins