title: The two-way paradigm of transplantation immunology.
abstract: The events following organ transplantation require a reciprocal cell interaction which includes both the conventional host-versus-graft reaction and a graft-versus-host component. With all successful transplantation, both graft and recipient become genetic composites. Where donors were available, chimerism has been confirmed in 30-year kidney-recipient survivors, as well as in several liver and lung recipients. A majority of liver recipients have been able to acquire an immunosuppressant-free state after 10-year survival. Animal models suggest that donor-derived cells may exert a tolerogenic effect.
authors.affiliation: Pittsburgh Transplant Institute, University of Pittsburgh Medical Center, Pennsylvania 15213, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Rao
authors.forename: T E
authors.initials: TE
authors.lastname: Starzl
authors.forename: A J
authors.initials: AJ
authors.lastname: Demetris
authors.forename: M
authors.initials: M
authors.lastname: Trucco
authors.forename: A
authors.initials: A
authors.lastname: Thomson
authors.forename: S
authors.initials: S
authors.lastname: Qian
authors.forename: N
authors.initials: N
authors.lastname: Murase
authors.forename: J J
authors.initials: JJ
authors.lastname: Fung
mesh_terms: D000818:Animals; D006085:Graft Survival / Q000276:immunology; D006086:Graft vs Host Disease / Q000276:immunology; D006789:Host vs Graft Reaction / Q000276:immunology; D006801:Humans; D018183:Transplantation Chimera; D014181:Transplantation Immunology