Effects of magnesium and potassium on Wolff-Parkinson-White syndrome.
To investigate the effects of electrolytes on anterograde conduction via accessory pathways, 12 patients with Wolff-Parkinson-White syndrome received, while in sinus rhythm, intravenous KCl (7 mEq in 200 mL of 0.9% NaCl), MgSO4 (10 mL 20% in 200 mL of 0.9% NaCl), NaCl (0.9%, 200 mL), and procainamide (maximal dose, 10 mg/kg of body weight over a 5-minute period) in a randomized fashion. NaCl had no effect on preexcitation. Procainamide abolished preexcitation in seven patients, of whom five had a similar response with MgSO4 and four with KCl. The finding that potassium and magnesium transiently abolish preexcitation in some Wolff-Parkinson-White patients deserves further study, especially during tachyarrhythmias in patients with accessory pathways.
Sideris
A M
AM
First Department of Cardiology, Evangelismos Hospital, Athens, Greece.
Galiatsu
E
E
Filippatos
G S
GS
Kappos
K
K
Anthopoulos
L P
LP
D000293:Adolescent; D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D008274:Magnesium / Q000097:blood; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D011188:Potassium / Q000097:blood; D011189:Potassium Chloride / Q000008:administration & dosage*; D011342:Procainamide / Q000008:administration & dosage*; D014927:Wolff-Parkinson-White Syndrome / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology
D000889:Anti-Arrhythmia Agents; D011189:Potassium Chloride; D008278:Magnesium Sulfate; D008274:Magnesium; D011342:Procainamide; D011188:Potassium