Effect of amino acids on the stability properties of nitrofurantoin suspensions. Flocculation and redispersion compared with interaction energy curves.
The influence of the addition of amino acids, lysine, alanine and glutamic acid on the properties of nitrofurantoin suspensions was investigated. Flocculation and redispersability was investigated, taking into account the electrical properties of the nitrofurantoin/solution interface. We conclude that lysine and glutamic acid, but not alanine, would be suitable amino acids for control of the stability of nitrofurantoin suspensions.
Gallardo
V
V
Pharmacy and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Granada, Spain.
Ruiz
M A
MA
Vera
P
P
Gonzalez-Caballero
F
F
Delgado
A V
AV
D000409:Alanine / Q000494:pharmacology; D000596:Amino Acids / Q000494:pharmacology*; D004355:Drug Stability; D004563:Electrochemistry; D005427:Flocculation; D018698:Glutamic Acid / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008239:Lysine / Q000494:pharmacology; D009582:Nitrofurantoin / Q000737:chemistry*; D010316:Particle Size; D012995:Solubility; D013535:Suspensions
D000596:Amino Acids; D013535:Suspensions; D018698:Glutamic Acid; D009582:Nitrofurantoin; D008239:Lysine; D000409:Alanine