Activation of B lymphocytes: integrating signals from CD19, CD22 and Fc gamma RIIb1.
Three accessory membrane proteins, CD19, CD22 and Fc gamma RIIb1, alter signaling through membrane immunoglobulin of B cells by binding cytosolic proteins containing SH2 domains. Recent biochemical and genetic studies have shown that these receptors enable B cells to amplify responses to certain T-cell-dependent antigens (CD19), to restrict their response to T-cell zones of secondary lymphoid organs (CD22), and to dampen their response to antigens for which IgG is already available (Fc gamma RIIb1).
Doody
G M
GM
Wellcome Trust Immunology Unit, University of Cambridge, School of Clinical Medicine, UK.
Dempsey
P W
PW
Fearon
D T
DT
D000818:Animals; D015703:Antigens, CD / Q000502:physiology*; D018941:Antigens, CD19 / Q000502:physiology*; D000944:Antigens, Differentiation, B-Lymphocyte / Q000502:physiology*; D001402:B-Lymphocytes / Q000276:immunology*; D015815:Cell Adhesion Molecules; D006801:Humans; D037102:Lectins; D008213:Lymphocyte Activation; D017452:Receptors, IgG / Q000502:physiology*; D051918:Sialic Acid Binding Ig-like Lectin 2; D015398:Signal Transduction / Q000276:immunology*
D015703:Antigens, CD; D018941:Antigens, CD19; D000944:Antigens, Differentiation, B-Lymphocyte; C497867:CD22 protein, human; D015815:Cell Adhesion Molecules; D037102:Lectins; D017452:Receptors, IgG; D051918:Sialic Acid Binding Ig-like Lectin 2