title: Treatment of nonoccupational limb and trunk dystonia with botulinum toxin.
abstract: We report the results of treatment of 16 patients (14 women, two men; 18-81 years old) with nonoccupational limb and trunk dystonia with botulinum toxin A (BTX; Dysport). A total of 18 clinical problems were identified. Outcomes were assessed in terms of pain relief and improvement in posture and function by the combined observations of the patient and physician. Patients' satisfaction with treatment was high--the benefit in 15 of 18 problems was rated as good to excellent. Reduction in pain was achieved in nine of 10 painful problems, with total relief in four cases. Some normalisation of posture was obtained in 17 of 18; it was complete in three cases. Functional improvement was less common (10 of 18). Excessive weakness was the most common side effect, affecting five patients, but it was disabling in only two. We conclude that BTX can provide substantial benefit with minimal side effects in the majority of patients with these conditions, particularly with pain relief and postural improvements.
authors.affiliation: National Hospital for Neurology and Neurosurgery, London, England.
authors.forename: J A
authors.initials: JA
authors.lastname: Quirk
authors.forename: G L
authors.initials: GL
authors.lastname: Sheean
authors.forename: C D
authors.initials: CD
authors.lastname: Marsden
authors.forename: A J
authors.initials: AJ
authors.lastname: Lees
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D004185:Disability Evaluation; D004305:Dose-Response Relationship, Drug; D004421:Dystonia / Q000188:drug therapy* / Q000209:etiology; D004576:Electromyography / Q000187:drug effects; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000187:drug effects; D010147:Pain Measurement; D016896:Treatment Outcome
chemical_list: D019274:Botulinum Toxins, Type A