Micronuclear and macronuclear sequences of a Euplotes crassus gene encoding a putative nuclear protein kinase.
The sequences of a 1.8-kbp macronuclear DNA molecule (V3), and the majority of its micronuclear counterpart, are reported. The macronuclear V3 DNA molecule contains an open reading frame that is interrupted by a single intron, while the micronuclear copy is interrupted by four internal eliminated sequences, one of which is located within the intron. The predicted protein product of the macronuclear V3 gene is a 471-amino acid polypeptide that is very similar to a group of protein-serine/threonine kinases from both plant and animal species, some of whose members appear to be involved in cell cycle or growth control.
Hale
C A
CA
Department of Biochemistry, University of Connecticut Health Center, Farmington 06030, USA.
Jacobs
M E
ME
Estes
H G
HG
Ghosh
S
S
Klobutcher
L A
LA
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002467:Cell Nucleus / Q000235:genetics; D016054:DNA, Protozoan / Q000032:analysis; D016812:Euplotes / Q000201:enzymology* / Q000235:genetics; D017125:Genes, Protozoan; D006801:Humans; D048631:Micronucleus, Germline / Q000235:genetics; D008969:Molecular Sequence Data; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
D016054:DNA, Protozoan; D017346:Protein Serine-Threonine Kinases