title: Myocardial suppression in vivo by spin locking with composite pulses.
abstract: Improved myocardium-blood contrast by myocardial suppression resulting from T1 rho-weighting in contrast-enhanced, gradient-echo, bright-blood cine images, acquired at 1.5T, is shown. In the standard images, blood has twice the intensity of muscle. In similar T1 rho-weighted images, it has 3-4 times the intensity of muscle. A composite spin-lock pulse before each observation pulse provides T1 rho-weighting. A typical pulse was: 90y-135x-360x-135x-90(-y) with element durations: 0.84, 1.26, 8.12, 1.26, and 0.84 ms. The tolerance of this composite pulse to shimmering and frequency errors allows spin locking with comparatively weak RF and therefore low specific absorption rate (SAR). Initial clinical evaluation on patients with poor ventricular function demonstrates both a qualitative and quantitative improvement in delineation of myocardial borders.
authors.affiliation: Frederik Philips Magnetic Resonance Research Center, Emory University Department of Radiology, Atlanta, Georgia, USA.
authors.forename: W T
authors.initials: WT
authors.lastname: Dixon
authors.forename: J N
authors.initials: JN
authors.lastname: Oshinski
authors.forename: J D
authors.initials: JD
authors.lastname: Trudeau
authors.forename: B C
authors.initials: BC
authors.lastname: Arnold
authors.forename: R I
authors.initials: RI
authors.lastname: Pettigrew
mesh_terms: D000042:Absorption; D001769:Blood; D003287:Contrast Media; D003326:Coronary Circulation; D003327:Coronary Disease / Q000175:diagnosis / Q000473:pathology; D004578:Electron Spin Resonance Spectroscopy; D005682:Gadolinium; D019786:Gadolinium DTPA; D006321:Heart / Q000033:anatomy & histology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods; D009206:Myocardium / Q000473:pathology; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D019047:Phantoms, Imaging; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000473:pathology
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA