A pharmacophore for high affinity PAF antagonists. I. Electronic model using molecular electrostatic potential.
PAF is a powerful phospholipid-derived autacoid involved in many physio-pathological mechanisms. Many PAF antagonists have been synthesized and assayed for therapeutic purposes. In this study, molecular electrostatic potential is used to compare the electronic properties of 48 'heterocyclic sp2 nitrogen' highly potent PAF antagonists, belonging to six series (nine hetrazepines, five pyrrolo[1,2-c]thiazoles, 14 carboxamides, nine dihydropyridines, nine pyridinylthiazolidines and two imidazo[4,5-c]pyridines). Their common features consist of three main electronegative zones (A, B1 and B2) describing the electronic pharmacophore of these ligands. The high affinity of these PAF antagonists seems to be related to this electronegative system A-B(x), which is characterized by three distances A-B1 (9.3 +/- 1.0 A), A-B2 (13.4 +/- 0.7 A) and B1-B2 (4.9 +/- 0.9 A). Moreover, B1 and B2 may surround a common anchorage point in the binding site of the receptor.
Le Solleu
H
H
G.E.R.S.A.A.C., Laboratoire de Chimie Analytique, UFR des Sciences Pharmaceutiques, Université de Bordeaux II, France.
Laguerre
M
M
Saux
M
M
Dubost
J P
JP
D008956:Models, Chemical; D015394:Molecular Structure; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors* / Q000737:chemistry
D010972:Platelet Activating Factor