title: Chronic intoxication with lead- and sulfur compounds may produce Parkinson's disease.
abstract: Parkinson's disease was found in three post office workers who were in close contact with lead-sulfate batteries over a period between 1947 and 1983. The workers had been working in a charging station for lead storage batteries used for the battery-traction of post wagons. Parkinson's disease was diagnosed by the characteristic features of rigidity, tremor and elements of hypo-, brady- and akinesia. Additional symptoms were: bradyphrenia (n = 3), memory deficits (n = 3), depressive symptoms (n = 2) and peripheral neuropathy (n = 2). We hypothesize that the parkinsonian symptoms of these post office workers are primarily caused by lead or lead compounds. However a possible toxicity of sulfur containing compounds cannot be ruled out.
authors.affiliation: Department of Neurology, Ruhr-University Bochum, Federal Republic of Germany.
authors.forename: R
authors.initials: R
authors.lastname: Winkel
authors.forename: W
authors.initials: W
authors.lastname: Kuhn
authors.forename: H
authors.initials: H
authors.lastname: Przuntek
mesh_terms: D000368:Aged; D002908:Chronic Disease; D006801:Humans; D007855:Lead Poisoning / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure; D010302:Parkinson Disease, Secondary / Q000139:chemically induced*; D013431:Sulfates / Q000506:poisoning*
chemical_list: D013431:Sulfates