Scutione, a new bioactive norquinonemethide triterpene from Maytenus scutioides (Celastraceae).
Scutione (1), a new norquinonemethide triterpene with a netzahualcoyene type skeleton, has been isolated from the root bark of Maytenus scutioides (Celastraceae) by bioactivity-directed fractionation. The structure of 1 has been elucidated by means of 1H and 13C NMR spectroscopic studies, including 1H-13C heteronuclear correlation (HETCOR), a long-range correlation spectrum with inverse detection (HMBC) and ROESY experiments. Compound 1 showed antibiotic activity against Gram-positive bacteria and modest cytotoxic activity against HeLa, Hep-2 and Vero cell lines. Fluoride derivatives 2-4 were prepared and assayed for bioactivity, where 2 showed slight improvement of the cytotoxic potency.
González
A G
AG
Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, Tenerife, Canary Islands, Spain.
Alvarenga
N L
NL
Ravelo
A G
AG
Bazzocchi
I L
IL
Ferro
E A
EA
Navarro
A G
AG
Moujir
L M
LM
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D006367:HeLa Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D010944:Plants / Q000737:chemistry; D013057:Spectrum Analysis; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014709:Vero Cells
D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C103715:scutione