title: [High uptake of N-isopropyl-p-[123I]-iodoamphetamine (123I-IMP) demonstrated by dynamic SPECT in some cases of glioma].
abstract: Selective high uptake of N-isopropyl-p-[123I]-iodoamphetamine (123I-IMP) in the brain tumors is not common, the mechanism of uptake in the brain tumor is not yet clearly understood. Among 26 cases of gliomas investigated by dynamic SPECT, 4 cases including 2 cases of anaplastic astrocytoma and 2 cases of oligodendroglioma, showed high uptake of 123I-IMP. New three detector type camera which enables us to investigate rapid successive scanning, was used in our study. In dynamic SPECT, 15 successive scans of 2 minutes interval were made for 30 minutes after administration of 123I-IMP. In addition, quick dynamic SPECT was tried in 2 cases, in which 10 quick successive scans of 24 seconds interval were investigated for initial 4 minutes immediately after administration of 123I-IMP. Radioactivity in the region of interest inside the tumor (T) and radioactivity of the corresponding site in the contralateral hemisphere (C) was measured respectively, and T/C ratio was calculated. Time course change of radioactivity (time activity curve: TAC) was analyzed in all cases. Radioactivity was always higher in the tumor and the average T/C ratio was 1.40. TAC showed rapid increase of 123I-IMP in the tumor during initial 2 minutes after administration and keeping its high plateau level for 30 minutes. Angiography in these cases revealed a remarkable tumor stain. On the other hand, these gliomas showed no or slight enhancement effect in CT or MRI. These findings are interpretable as that early high uptake of 123I-IMP in some gliomas is attributable to an increased vascular bed and blood flow with no or minimal derangement of blood brain barrier in these tumors.
authors.affiliation: Department of Neurosurgery, Toho University School of Medicine.
authors.forename: N
authors.initials: N
authors.lastname: Sugou
authors.forename: I
authors.initials: I
authors.lastname: Shibata
authors.forename: A
authors.initials: A
authors.lastname: Nemoto
authors.forename: M
authors.initials: M
authors.lastname: Nemoto
authors.forename: H
authors.initials: H
authors.lastname: Ohishi
authors.forename: T
authors.initials: T
authors.lastname: Kuroki
authors.forename: Y
authors.initials: Y
authors.lastname: Seiki
authors.forename: H
authors.initials: H
authors.lastname: Terao
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Takano
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
mesh_terms: D000328:Adult; D000662:Amphetamines / Q000493:pharmacokinetics*; D001812:Blood-Brain Barrier / Q000502:physiology; D001932:Brain Neoplasms / Q000098:blood supply* / Q000175:diagnosis / Q000378:metabolism; D002533:Cerebral Angiography; D005260:Female; D005909:Glioblastoma / Q000098:blood supply* / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D020367:Iofetamine; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009837:Oligodendroglioma / Q000098:blood supply* / Q000175:diagnosis / Q000378:metabolism; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine