title: Chemiluminescence flow-injection analysis of captopril applying a sensitized rhodamine 6G method.
abstract: A flow-injection analysis with chemiluminescence detection is described for the determination of captopril based on the photochemical reaction with cerium(IV) in sulphuric acid medium yielding a strong chemiluminescent signal which can be sensitized by some fluorescers. The proposed procedure has a linear application range of 1 x 10(-6) - 2 x 10(-4) M (r = 0.997) with a detection limit of 2 x 10(-7) M, an RSD of 2.8% at 1 x 10(-6) M captopril, and a sample measurement frequency of 500 h-1. The method was used for the simple and rapid determination of captopril in a pharmaceutical preparation.
authors.affiliation: Department of Pharmaceutical Analysis, Faculty of Pharmaceutical Sciences, University of Ghent, Belgium.
authors.forename: Z D
authors.initials: ZD
authors.lastname: Zhang
authors.forename: W R
authors.initials: WR
authors.lastname: Baeyens
authors.forename: X R
authors.initials: XR
authors.lastname: Zhang
authors.forename: G
authors.initials: G
authors.lastname: Van der Weken
mesh_terms: D002216:Captopril / Q000032:analysis*; D002563:Cerium; D004396:Coloring Agents; D017022:Flow Injection Analysis / Q000379:methods; D008163:Luminescent Measurements; D012235:Rhodamines; D013464:Sulfuric Acids; D013607:Tablets / Q000032:analysis
chemical_list: D004396:Coloring Agents; D012235:Rhodamines; D013464:Sulfuric Acids; D013607:Tablets; C026188:rhodamine 6G; D002563:Cerium; D002216:Captopril; C033158:sulfuric acid