title: Lymphoid involvement in a patient with acute myeloid leukemia: a direct phenotypic and genotypic study of single cells.
abstract: Lymphoid involvement in acute myeloid leukemia (AML) was studied using the morphology-antibody-chromosome (MAC) combination technique in one patient. The chromosomal aberration, trisomy 8, was demonstrated in AML blasts, glycophorin A-positive erythroblasts, and CD3- and CD20/22-positive small lymphocytes. This suggests that in this patient even lymphocytes belonged to the leukemic clone.
authors.affiliation: Department of Medical Genetics, University of Helsinki, Finland.
authors.forename: W
authors.initials: W
authors.lastname: El-Rifai
authors.forename: M L
authors.initials: ML
authors.lastname: Larramendy
authors.forename: T
authors.initials: T
authors.lastname: Ruutu
authors.forename: S
authors.initials: S
authors.lastname: Knuutila
mesh_terms: D000208:Acute Disease; D000368:Aged; D002454:Cell Differentiation; D002898:Chromosomes, Human, Pair 8; D005260:Female; D005838:Genotype; D006801:Humans; D016130:Immunophenotyping; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D010641:Phenotype; D014314:Trisomy; D014407:Tumor Cells, Cultured