Cutaneous leishmaniasis: a model for analysis of the immunoregulation by accessory cells.
In the mammalian host, Leishmania are obligate intracellular parasites and invade macrophages and Langerhans cells. The accessory functions of both types of host cells are important for regulation of the specific cellular immune response and involve the following activities: infiltration into the site of infection, initiation of a T cell response, maintenance of immunity and the effector mechanisms that control intracellular parasite replication.
Moll
H
H
Research Center for Infectious Diseases, University of Würzburg, Germany.
Ritter
U
U
Flohé
S
S
Erb
K
K
Bauer
C
C
Blank
C
C
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D018925:Chemokines / Q000494:pharmacology; D004195:Disease Models, Animal; D006801:Humans; D016773:Leishmaniasis, Cutaneous / Q000276:immunology*; D051379:Mice; D009569:Nitric Oxide / Q000494:pharmacology
D018925:Chemokines; D009569:Nitric Oxide