title: Exercise fails to improve postprandial glycemic excursion in women with gestational diabetes.
abstract: The effect of an acute period of moderate intensity exercise on maternal glycemic excursion following a mixed nutrient meal was studied. Five normal (NL) and six gestational diabetic (GDM) subjects were enrolled. A randomized crossover design was used to compare fasting glucose and insulin levels, peak glucose and insulin levels and incremental area of the glycemic and insulin curves following a mixed nutrient meal with or without an exercise stress that took place 14 h earlier. Exercise consisted of upright stationary cycling for 30 min at a heart rate consistent with 60% VO2max. The clinical characteristics of normal and gestational diabetic subjects were comparable. Mean values (+/-SEM) with, versus without, exercise for fasting glucose (NL: 78.9 +/- 2.6 vs. 80.0 +/- 2.6 mg/dl; GDM: 86.4 +/- 2.0 vs. 82.1 +/- 3.5 mg/ dl), peak glucose (NL: 132.3 +/- 10.4 vs. 139.1 +/- 15.6 mg/dl; GDM: 165.8 +/- 5.5 vs. 160.3 +/- 7.8 mg/dl), the area under the glycemic curve (NL: 5758 +/- 1038 vs. 6393 +/- 1281 mg/dl.min; GDM: 8,178 +/- 890 vs. 8,331 +/- 563 mg/dl.min) did not differ. Similarly, plasma insulin levels did not differ between protocols for either group of subjects. Exercise has been proposed as a treatment to reduce glycemia in gestational diabetes. Results from this study indicate a single bout of exercise did not blunt the glycemic response observed following a mixed nutrient meal.
authors.affiliation: Department of Obstetrics and Gynecology, Women and Infants Hospital, Brown University School of Medicine, Providence, Rhode Island, USA.
authors.forename: K B
authors.initials: KB
authors.lastname: Lesser
authors.forename: P A
authors.initials: PA
authors.lastname: Gruppuso
authors.forename: R B
authors.initials: RB
authors.lastname: Terry
authors.forename: M W
authors.initials: MW
authors.lastname: Carpenter
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D018592:Cross-Over Studies; D016640:Diabetes, Gestational / Q000097:blood / Q000503:physiopathology*; D004435:Eating; D015444:Exercise; D005080:Exercise Test; D005260:Female; D006339:Heart Rate; D006801:Humans; D007328:Insulin / Q000097:blood*; D011247:Pregnancy; D011897:Random Allocation; D012016:Reference Values; D012044:Regression Analysis; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin