Genetic relationship between dopamine transporter gene and schizophrenia: linkage and association.
This study explores the genetic relationship between schizophrenia and the dopamine transporter gene (DAT) by a variety of methods. In a sample of 48 families--each family containing at least one nuclear family with a pair of affected siblings--we performed linkage analysis using the maximum likelihood (LOD score) method as well as sibpair analysis (identity by descent). In addition, we investigated a sample of 108 nuclear families--index case affected with schizophrenia/chronic schizoaffective disorder--for association using the haplotype relative risk method. Linkage between schizophrenia and DAT using two- and three-point linkage analysis was excluded with all disease models employed. No evidence for association between haplotypes of the VNTR-probe of the DAT and schizophrenia has been detected. Thus, a contribution of the DAT gene to the genetic diathesis of schizophrenia is unlikely in the families studied.
Maier
W
W
Department of Psychiatry, University of Mainz, Germany.
Minges
J
J
Eckstein
N
N
Brodski
C
C
Albus
M
M
Lerer
B
B
Hallmayer
J
J
Fimmers
R
R
Ackenheil
M
M
Ebstein
R E
RE
Borrmann
M
M
Lichtermann
D
D
Wildenauer
D B
DB
D000328:Adult; D002352:Carrier Proteins / Q000235:genetics*; D002908:Chronic Disease; D050483:Dopamine Plasma Membrane Transport Proteins; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D018598:Minisatellite Repeats / Q000235:genetics; D008957:Models, Genetic; D009419:Nerve Tissue Proteins; D010641:Phenotype; D011618:Psychotic Disorders / Q000175:diagnosis / Q000235:genetics; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*
D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D005819:Genetic Markers; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493214:SLC6A3 protein, human