PTPN13, a fas-associated protein tyrosine phosphatase, is located on the long arm of chromosome 4 at band q21.3.
PTPN13 is a protein tyrosine phosphatase that associates with the C-terminal negative regulatory domain in the Fas (APO-1/CD95) receptor. The PTPN13 protein contains six GLGF repeats that have been found in the rat postsynaptic density protein (PSD-95) and the Drosophila tumor suppressor protein, lethal-(1)-disc-large-1 (dlg-1). The localization of the PTPN13 gene to human chromosome 4q21.3 was determined by both FISH and PCR analysis of somatic cell hybrids. This 4q21.3 chromosomal region contains a gene for autosomal dominant polycystic kidney disease as well as the region frequently deleted in liver and ovarian cancers, suggesting that PTPN13 is a candidate for one of the putative tumor suppressor genes on the long arm of chromosome 4.
Inazawa
J
J
Department of Hygiene, Kyoto Prefectural University of Medicine, Japan.
Ariyama
T
T
Abe
T
T
Druck
T
T
Ohta
M
M
Huebner
K
K
Yanagisawa
J
J
Reed
J C
JC
Sato
T
T
D001483:Base Sequence; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D017931:DNA Primers; D015894:Genome, Human; D006801:Humans; D008969:Molecular Sequence Data; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D019014:fas Receptor / Q000378:metabolism*
D017931:DNA Primers; D019014:fas Receptor; D017027:Protein Tyrosine Phosphatases