[Cytogenetic markers in blood lymphocytes from members of a family with high predisposition to breast cancer].
A medico-genealogical study was concerned with a line consisting of 38 members. Four of 18 women had breast cancer (BrCr) and one-leukemia. BrCr was diagnosed in the 1st generation in the proband's grandmother (1-2) at the age of 40 and in the 3rd generation: in the proband (III-8) at the age of 43 and in two of her sisters at the age of 44 (III-2) and 48 (III-10), respectively. Breast tumors appeared in the 3rd generation patients approximately at the same age. A cytogenetic study of venous blood lymphocyte metaphases using G-banding of chromosomes revealed homogeneously-stained regions in 100% of cells in the proband's chromosome I: (q11-q12). In the proband's asymptomatic daughter (IV-9), pronounced chromosomal instability (ruptures in chromosomes and chromatids in 50% of cells) was observed. Also, single and multiple double minutes were detected in 10% of cells, while marker 14(p12-pter)-in 100%. This marker was also identified in 100% of lymphocytes taken from the asymptomatic daughter (IV-11) of the proband's sister (III-10). The nature and significance of cytogenetic markers detected in blood lymphocytes of the proband and said siblings are discussed. Heritability of said cytogenetic markers pointing to predisposition to cancer development (of BrCr in said family) is suggested.
Monakhov
A S
AS
Semiglazov
V F
VF
Brezhneva
T V
TV
D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000235:genetics*; D015984:Causality; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D005260:Female; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes; D008875:Middle Aged; D010375:Pedigree
D014408:Biomarkers, Tumor