[The changes of blood gas analysis values and platelet aggregability on acute phase in the experimental model of pulmonary embolism prepared by sephadex G-75 (SG-75) injection].
To study pathophysiologic phenomena in acute pulmonary embolism, we injected sephadex G-75 (SG-75) into rabbit auricular veins and measured the changes in blood gases and in platelet aggregability. Severe hypoxemia developed within 10 minutes of SG-75 injection. Microscopic examination of samples taken 120 minutes after SG-75 injection pulmonary artery had been embolized by the SG-75 particles, and that thrombin had formed around the particles. The lowest platelet counts were measured 10 minutes after SG-75 injection. The rates of platelet aggregation induced by adenosine diphosphate and by platelet-activating factor were abnormally low until 40 minutes after SG-75 injection. These results suggest that platelets were activated by anoxia and that the activated platelets moved around the emboli after obstruction of the pulmonary artery. We conclude that decreases in PaO2 and changes in platelet aggregability exacerbate the pathophysiologic processes in acute pulmonary embolism.
Yasugahira
H
H
Second Department of Internal Medicine, Hirosaki University, School of Medicine, Aomori-Prefecture, Japan.
Kanazawa
T
T
Takanashi
S
S
Onodera
K
K
D000210:Acute-Phase Reaction; D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000097:blood*; D003911:Dextrans; D004195:Disease Models, Animal; D008297:Male; D010100:Oxygen / Q000097:blood*; D010972:Platelet Activating Factor / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count; D011655:Pulmonary Embolism / Q000097:blood* / Q000139:chemically induced / Q000473:pathology; D011817:Rabbits
D003911:Dextrans; D010972:Platelet Activating Factor; D002245:Carbon Dioxide; D000244:Adenosine Diphosphate; C025614:sephadex; D010100:Oxygen