Fanconi's anaemia and recurrent squamous cell carcinoma of the oral cavity: a case report.
Fanconi's anaemia is a rare genetic disorder and majority of the patients die of haematologic complications in their second or third decades of life. Others who have mild or no cytopenias survive long enough to develop malignancies. This is a report of a 44-year-old woman who presented with recurrent oral squamous cell carcinoma during her adulthood, without clinical haematological problem. Despite treatment with cis-retinoic acid, she developed a third squamous cell carcinoma 6 months later. In a review of the literature, only in 1 reported case was the patient treated with low-dose retinoids but he developed recurrent anal cancer after 14 months.
Koo
W H
WH
Department of Medical Oncology, Singapore General Hospital, Singapore.
Knight
L A
LA
Ang
P T
PT
D000293:Adolescent; D000328:Adult; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D002648:Child; D004285:Dogs; D005199:Fanconi Anemia / Q000150:complications* / Q000503:physiopathology; D005260:Female; D006801:Humans; D009062:Mouth Neoplasms / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012086:Reoperation; D015996:Survival Rate; D014212:Tretinoin / Q000008:administration & dosage / Q000627:therapeutic use
D000970:Antineoplastic Agents; D014212:Tretinoin