title: Structural classification of proteins: new superfamilies.
abstract: The structural classification of proteins reveals that it is already more likely to find that a new protein structure has similarity to another structure than to find that it has a new fold. Reviewed here are those new superfamilies that include proteins of general interest: Sonic hedgehog, macrophage migration inhibitory factor, nuclear transport factor-2, double stranded RNA binding domain, GroES, the proteasome, new ATP-hydrolyzing ligases and flavoproteins.
authors.affiliation: Centre for Protein Engineering, Medical Research Council Centre, Cambridge, UK. agm@mrc-lmb.cam.ac.uk
authors.forename: A G
authors.initials: AG
authors.lastname: Murzin
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000426:Alcohol Dehydrogenase / Q000737:chemistry; D002352:Carrier Proteins / Q000737:chemistry; D018835:Chaperonin 10 / Q000737:chemistry; D005182:Flavin-Adenine Dinucleotide / Q000378:metabolism; D053823:Hedgehog Proteins; D006801:Humans; D008025:Ligases / Q000737:chemistry / Q000378:metabolism; D008263:Macrophage Migration-Inhibitory Factors / Q000737:chemistry; D008958:Models, Molecular; D009687:Nuclear Proteins / Q000737:chemistry; D029543:Nucleocytoplasmic Transport Proteins; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry / Q000145:classification*; D012330:RNA, Double-Stranded / Q000737:chemistry; D015534:Trans-Activators
chemical_list: D002352:Carrier Proteins; D018835:Chaperonin 10; D053823:Hedgehog Proteins; D008263:Macrophage Migration-Inhibitory Factors; D009687:Nuclear Proteins; D029543:Nucleocytoplasmic Transport Proteins; D011506:Proteins; D012330:RNA, Double-Stranded; C509239:SHH protein, human; D015534:Trans-Activators; D005182:Flavin-Adenine Dinucleotide; D000255:Adenosine Triphosphate; D000426:Alcohol Dehydrogenase; D008025:Ligases