[Signal transduction system in cardiac cells].
The electrical excitation and conduction in the heart is due to ionic events via ion channels and gap junctions. Function of these channels and gap junctions is regulated by intracellular milieu, which is regulated by many kinds of receptors through intracellular second messengers i.e.; GTP binding proteins, protein kinases, Ca2+ concentrations, H+ concentration, cyclic nucleotides and triphosphate nucleotides. In this paper, we focus on signal transduction systems in cardiac myocytes. Subsequently, some of interactions between signal transduction systems are introduced.
Kaibara
M
M
Second Department of Pharmacology, Nagasaki University, School of Medicine.
Hayano
M
M
Yano
K
K
D000242:Cyclic AMP / Q000502:physiology; D006152:Cyclic GMP / Q000502:physiology; D004594:Electrophysiology; D019204:GTP-Binding Proteins / Q000502:physiology; D006321:Heart / Q000502:physiology*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism / Q000502:physiology; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D011494:Protein Kinases / Q000502:physiology; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction
D007473:Ion Channels; D000242:Cyclic AMP; D011494:Protein Kinases; D019204:GTP-Binding Proteins; D006152:Cyclic GMP