Allergic contact dermatitis from azathioprine.
A 51-year-old production mechanic for a pharmaceutical company complained of a dermatitis involving his hands. The onset of the eruption coincided with when he was placed on the production packing line for azathioprine tablets. Patch testing showed a positive allergic reaction only to azathioprine diluted in petrolatum. A pharmaceutical product such as azathioprine may need to be considered as a cause for allergic contact dermatitis in patients with a history of exposure during the manufacturing process.
Soni
B P
BP
Department of Dermatology, Bowman, Gray School of Medicine of Wake Forest University, Winston-Salem, NC, USA.
Sherertz
E F
EF
D001379:Azathioprine / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000209:etiology / Q000503:physiopathology; D009783:Dermatitis, Occupational / Q000209:etiology* / Q000503:physiopathology; D004345:Drug Industry; D006229:Hand Dermatoses / Q000139:chemically induced*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged
D007166:Immunosuppressive Agents; D001379:Azathioprine