Systemic anti-inflammatory effect induced by antidromic stimulation of the dorsal roots in the rat.
Neurogenic inflammation and other local efferent functions of the capsaicin-sensitive nerve endings is well established. Here, we describe evidence for a systemic neurogenic anti-inflammatory effect initiated in the rat by this local response. A preceding local neurogenic inflammation induced by antidromic stimulation of lumbar dorsal roots inhibited a subsequent inflammatory response due to antidromic stimulation of the contralateral dorsal roots or evoked by subplantar carrageenin injection or instillation of capsaicin solution into the eye. Initiation of these anti-inflammatory responses were prevented by degeneration of the capsaicin-sensitive afferents after perineural capsaicin pre-treatment, but not by bilateral adrenalectomy. These results demonstrate an unorthodox new type of neurohumoral regulatory mechanism of sensory fibres and provide a possible mode of action for the anti-inflammatory effect of counter-irritation and acupuncture.
Pintér
E
E
Department of Pharmacology, University Medical School of Pécs, Hungary.
Szolcsányi
J
J
D000315:Adrenalectomy; D000818:Animals; D002211:Capsaicin / Q000494:pharmacology; D002351:Carrageenan; D004396:Coloring Agents; D004558:Electric Stimulation; D005070:Evans Blue; D005079:Excipients; D005260:Female; D005727:Ganglia, Spinal / Q000187:drug effects* / Q000502:physiology*; D009443:Neuritis / Q000503:physiopathology*; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D015320:Tachykinins / Q000378:metabolism
D004396:Coloring Agents; D005079:Excipients; D015320:Tachykinins; D005070:Evans Blue; D002351:Carrageenan; D002211:Capsaicin