Anti-Ro/SSA associated recurrent annular erythema: autoimmune response to recombinant 60- and 52-kDa Ro/SSA proteins.
Recurrent annular erythema associated with anti-Ro/SSA antibody response has recently been recognized as a distinct clinical entity. Serum samples from 15 anti-Ro/SSA positive patients with recurrent annular erythema were tested by enzyme-linked immunosorbent assay (ELISA) for reactivity with full-length recombinant human 60-kDa and 52-kDa Ro/SSA proteins. All the 15 sera were positive for anti-60-kDa Ro/SSA, and 11 sera (73.3%) contained anti-52-kDa Ro/SSA. These results suggest the importance of 60-kDa polypeptide component of the Ro/SSA particle as a potential target in anti-Ro/SSA associated annular erythema.
Miyagawa
S
S
Department of Dermatology, Nara Medical University, Japan.
Fukumoto
T
T
Hachiya
T
T
Shirai
T
T
D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D001324:Autoantigens / Q000737:chemistry / Q000494:pharmacology*; D015551:Autoimmunity / Q000187:drug effects*; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D004890:Erythema / Q000276:immunology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D008970:Molecular Weight; D020733:RNA, Small Cytoplasmic; D011994:Recombinant Proteins; D012008:Recurrence; D012261:Ribonucleoproteins / Q000737:chemistry / Q000494:pharmacology*; D000099207:SS-A Antigen
D000974:Antibodies, Antinuclear; D001324:Autoantigens; D020733:RNA, Small Cytoplasmic; D011994:Recombinant Proteins; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C116006:RO60 protein, human; C035356:SS-A antibodies; C035357:SS-B antibodies