title: Comparison of centrifugal and roller pump hemolysis rates at low flow.
abstract: We compared in vitro rates of hemolysis for a recently developed centrifugal pump with a conventional roller pump (10-10-00; Stöckert, Munich, Germany). Flow rates of 0.3 L/min and 1 L/min and a pressure of 200 mm Hg were chosen to simulate conditions during neonatal extracorporeal membrane oxygenation (ECMO). There was no significant difference in hemolysis rates between centrifugal and roller pumps (p = 0.57) nor between high and low flow (p = 0.86). The centrifugal pump caused no more blood trauma than the roller pump at the low-flow/high-pressure conditions required for neonatal ECMO. The Nikkiso pump is superior to roller pumps in size and priming volume (25 ml) and may permit development of a smaller and simpler ECMO system.
authors.affiliation: Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Y S
authors.initials: YS
authors.lastname: Moon
authors.forename: S
authors.initials: S
authors.lastname: Ohtsubo
authors.forename: M R
authors.initials: MR
authors.lastname: Gomez
authors.forename: J K
authors.initials: JK
authors.lastname: Moon
authors.forename: Y
authors.initials: Y
authors.lastname: Nosé
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D002417:Cattle; D002498:Centrifugation; D004912:Erythrocytes / Q000166:cytology / Q000473:pathology; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects / Q000592:standards* / Q000639:trends; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis; D066298:In Vitro Techniques; D011312:Pressure
chemical_list: D006454:Hemoglobins