title: Pregnancy induced hypertension and antithrombin-III.
abstract: This study was undertaken to determine the coagulation profile of women with pregnancy induced hypertension and to evaluate the changes in the level of AT-III in pre-eclampsia and eclampsia and its correlation with severity of disease in order to evaluate if it can be used as a marker for severity of PIH. 119 women with PIH in the third trimester of pregnancy constituted the study group. Age and parity matched 25 normal pregnant and 25 non-pregnant women were taken as control group. No significant difference between the coagulation profile of non-pregnant and normal pregnant women was seen. There is evidence of consumption coagulopathy in PIH patients and AT-III activity shows a gradual and almost linear reduction in various groups ranging from normal pregnant women to eclampsia. Reduction in AT-III activity has positive correlation with PIH and it can be a useful marker for severity of PIH.
authors.affiliation: Department of Obstetrics and Gynaecology, Safdarjang Hospital, New Delhi.
authors.forename: M
authors.initials: M
authors.lastname: Srivastava
authors.forename: S
authors.initials: S
authors.lastname: Bali
authors.forename: J
authors.initials: J
authors.lastname: Pandey
authors.forename: V
authors.initials: V
authors.lastname: Nayar
authors.forename: V H
authors.initials: VH
authors.lastname: Talib
mesh_terms: D000990:Antithrombin III / Q000378:metabolism*; D001777:Blood Coagulation; D004461:Eclampsia / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007194:India; D011225:Pre-Eclampsia / Q000097:blood* / Q000503:physiopathology; D011247:Pregnancy; D011507:Proteinuria / Q000097:blood
chemical_list: D000990:Antithrombin III