Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease.
We have studied the relationship between the apolipoprotein E gene (APOE) and the development of myoclonus, tremors, rigidity and seizures in 168 patients with probable early-onset Alzheimer's disease (AD). There was a statistically significantly lower risk of tremor for carriers of the epsilon 4 allele of APOE. This allele was also associated with an increased risk of myoclonus. Our findings suggest that there may be differences in progression and clinical appearance in early-onset AD related to the APOE genotype.
Bronzova
J
J
Department of Epidemiology & Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.
van Duijn
C M
CM
Havekes
L M
LM
de Knijff
P
P
Van Broeckhoven
C
C
Hofman
A
A
D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology; D001053:Apolipoproteins / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis
D001053:Apolipoproteins