Role of Fas-mediated cell death in the regulation of immune responses.
Interaction of the cell-surface molecule Fas (CD95 APO-1) with its specific ligand triggers apoptotic death of T and B lymphocytes. This pathway is important for eliminating self-reactive lymphocytes and thus preventing autoimmunity. Fas is also involved in controlling injurious lymphocyte reactions in immunologically 'privileged' tissues, and may provide a strategy for reducing graft rejection.
Van Parijs
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Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA. lukvp@bustoff.bwh.harvard.edu
Abbas
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AK
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D016923:Cell Death / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology*; D019014:fas Receptor / Q000502:physiology*
D019014:fas Receptor