Endothelium activation related increase of soluble intercellular adhesion molecule-1 in human schistosomiasis. Lack of correlation with serology.
Soluble intercellular adhesion molecule-1 (sICAM-1) level was measured in sera from 41 patients with Schistosoma mansoni schistosomiasis and compared with the sICAM-1 level in 41 healthy subjects. A significant increase in serum sICAM-1 was observed in patients with schistosomiasis compared with control subjects. As they were inhabitants of the French Antilles, the patients were, however, not settled in a malaria endemic zone, allowing this cause of sICAM-1 enhancement to be eliminated. No correlation was found between the level of sICAM-1 and the schistosomiasis serological titre. Such results favour the hypothesis of an activation of vascular endothelial cells due to egg deposition.
Lejoly-Boisseau
H
H
Laboratoire d'Immunologie et Biologie Parasitaire, Universiaté de Bordeaux II, France.
Blann
A D
AD
Seigneur
M
M
Tribouley-Duret
J
J
Tribouley
J
J
Boisseau
M R
MR
D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D012555:Schistosomiasis mansoni / Q000097:blood* / Q000276:immunology
D018799:Intercellular Adhesion Molecule-1