title: Outcome in paired recipients of single lung transplants from the same donor.
abstract: METHODS
  We compared outcome measures in twenty single lung transplant recipients: 10 patients received the first lung of a donor pair (group 1), and 10 patients received the second lung (group 2) to determine the feasibility of sequential use, respectively, of donor lungs from the same donor in the same institution. The paired recipients underwent transplantation in the same operating room by the same surgical team. Both groups were well matched for age, gender, pretransplantation symptom class and diagnosis.
  
  
  RESULTS
  The ischemic time for group 1 versus group 2 was 164 +/- 53 minutes (mean +/- standard deviation) (range 103 to 250 minutes) versus 377 +/- 53 minutes (range 315 to 445 minutes), respectively, (p < 0.001), but the longer ischemic time for group 2 did not adversely affect time to extubation (10.5 +/- 5.1 hours versus 10.3 +/- 7.6 hours; p = Not significant), early gas exchange (partial pressure of arterial oxygen on a fractional concentration of oxygen in inspired gas of 0.60: 237 +/- 61 versus 267 +/- 88 mm Hg; p = Not significant), length of hospital stay (16 +/- 13 days versus 16 +/- 5 days; p = Not significant), or actuarial one-year survival (80 +/- 12% versus 90 +/- 12%; p = Not significant). However, acute lung rejection (expressed as events/100 days) was more common within the first 3 months in group 1 versus group 2 (2.68 +/- 0.57 versus 1.32 +/- 0.38, respectively; p < 0.01), as were infectious events (2.07 +/- 0.50 versus 0.99 +/- 0.33; p < 0.01).
  
  
  CONCLUSIONS
  These data confirm the safety of using the second lung from a donor pair sequentially in the same institution. The longer cold ischemic time for the second lung does not impair demonstrably early graft function and may be associated with a lower perioperative morbidity from acute rejection and subsequent infection. One-year outcome appears favorable for both groups.
authors.affiliation: Cardiopulmonary Transplant Unit, St Vincent's Hospital, Darlinghurst, Australia.
authors.forename: A R
authors.initials: AR
authors.lastname: Glanville
authors.forename: D
authors.initials: D
authors.lastname: Marshman
authors.forename: A
authors.initials: A
authors.lastname: Keogh
authors.forename: P
authors.initials: P
authors.lastname: Macdonald
authors.forename: R
authors.initials: R
authors.lastname: Larbalestier
authors.forename: A
authors.initials: A
authors.lastname: Kaan
authors.forename: D
authors.initials: D
authors.lastname: Bryant
authors.forename: P
authors.initials: P
authors.lastname: Spratt
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006084:Graft Rejection; D006801:Humans; D016040:Lung Transplantation / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009926:Organ Preservation; D015996:Survival Rate; D013997:Time Factors; D014019:Tissue Donors