title: Aspergillus laryngotracheobronchitis presenting as stridor in a patient with peripheral T cell lymphoma.
abstract: Invasive aspergillosis is a serious opportunistic infection in immunocompromised patients. The case history is described of a 44 year old patient with peripheral T cell lymphoma who developed hoarseness and stridor after chemotherapy. Aspergillus fumigatus was isolated repeatedly from the sputum. Bronchoscopic examination showed symmetrical creamy-white exophytic lesions involving both vocal cords and the supraglottic area. There was diffuse tracheobronchitis with multiple raised cream-coloured plaques in the trachea which histologically consisted of numerous septate branching hyphae consistent with Aspergillus species. The lesions responded to systemic treatment with amphotericin B.
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital, Taipei.
authors.forename: P H
authors.initials: PH
authors.lastname: Kuo
authors.forename: L N
authors.initials: LN
authors.lastname: Lee
authors.forename: P C
authors.initials: PC
authors.lastname: Yang
authors.forename: Y C
authors.initials: YC
authors.lastname: Chen
authors.forename: K T
authors.initials: KT
authors.lastname: Luh
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications* / Q000188:drug therapy; D001232:Aspergillus fumigatus; D001991:Bronchitis / Q000382:microbiology; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D007827:Laryngitis / Q000382:microbiology; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications* / Q000382:microbiology; D008297:Male; D012135:Respiratory Sounds / Q000209:etiology*; D012141:Respiratory Tract Infections / Q000150:complications* / Q000382:microbiology; D014136:Tracheitis / Q000382:microbiology
chemical_list: D017964:Itraconazole; D000666:Amphotericin B