Knockout mice and dirty drugs. Drug addiction.
Recent studies with knockout mice implicate the dopamine transporter as the target of the locomotor effects of the addictive psychomotor drugs cocaine and amphetamine; studies of reward in these animals are eagerly awaited.
Uhl
G R
GR
Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse Addiction Research Center, PO Box 5180, Baltimore, Maryland 21224, USA.
Vandenbergh
D J
DJ
Miner
L L
LL
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D002352:Carrier Proteins / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D003042:Cocaine / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D050483:Dopamine Plasma Membrane Transport Proteins; D008124:Locomotion / Q000187:drug effects; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D051379:Mice; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins; D009293:Opioid-Related Disorders / Q000235:genetics* / Q000378:metabolism
D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D000661:Amphetamine; D003042:Cocaine; D004298:Dopamine