Antiepileptic drug treatment during pregnancy and neonatal screening results.
Many antiepileptic drugs induce hepatic metabolic enzymes and thus enhance metabolism of steroid and thyroid hormones. Antiepileptic drugs readily cross the placenta and the foetal liver is metabolically active. We therefore evaluated the neonatal screening results of TSH and 17-hydroxyprogesterone in 34 study children and their matched controls. There were no statistically significant differences in the results between the groups.
Wide
K
K
Department of Paediatrics, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden.
Winbladh
B
B
Guthenberg
C
C
von Döbeln
U
U
D019326:17-alpha-Hydroxyprogesterone / Q000097:blood; D000927:Anticonvulsants / Q000009:adverse effects*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D015997:Neonatal Screening; D011247:Pregnancy; D013972:Thyrotropin / Q000097:blood
D000927:Anticonvulsants; D019326:17-alpha-Hydroxyprogesterone; D013972:Thyrotropin