title: Hematologic malignancies developing in Syrian golden hamsters during induction of pancreatic carcinoma.
abstract: We report 30 hematologic malignancies arising in 25 of 236 Syrian golden hamsters (SGH) that received combinations of N-nitrobis(2-oxopropyl)amine (BOP) and Streptozotocin (STZ). Lesions developed with morphological similarity to human small lymphocytic (n = 7), diffuse mixed (n = 2), diffuse large cell lymphoma (n = 13), follicular lymphoma (n = 2), anaplastic large cell lymphoma (n = 3), hairy cell leukemia (n = 2), malignant histiocytosis (n = 1) and discordant lymphomas (n = 5). The types and distribution of these lesions are different from epizootic lymphomas in SGH. We also report a higher percentage (12 versus 4.6%) and the earlier appearance (< or = 40 versus 80-112 weeks) compared with aging-associated spontaneous SGH lymphoma. The features of these hematologic malignancies have not been previously reported in epizootic or aging-associated spontaneous lymphomas and therefore suggest a new class of hematologic lesions in SGH. Benign and atypical hyperplasia correlated with STZ administration (r = 0.97, P = 0.03). The malignant lesions correlated with areas of lymphoid hyperplasia (r = 0.78, P= 0.004). Only one of the 21 untreated SGH spontaneously developed a low grade lymphoma. The unusual types, distribution and occurrence of these lesions may suggest a role for these carcinogens in their induction.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, OH 45267-0529, USA.
authors.forename: H D
authors.initials: HD
authors.lastname: Cualing
authors.forename: S P
authors.initials: SP
authors.lastname: Povoski
authors.forename: R S
authors.initials: RS
authors.lastname: Yassin
authors.forename: C M
authors.initials: CM
authors.lastname: Fenoglio-Preiser
authors.forename: R H
authors.initials: RH
authors.lastname: Bell
mesh_terms: D000375:Aging; D000818:Animals; D002273:Carcinogens; D006224:Cricetinae; D003921:Diabetes Mellitus, Experimental / Q000473:pathology; D004347:Drug Interactions; D019337:Hematologic Neoplasms / Q000139:chemically induced / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia; D007943:Leukemia, Hairy Cell / Q000139:chemically induced / Q000473:pathology*; D008221:Lymphoid Tissue / Q000187:drug effects / Q000473:pathology*; D008223:Lymphoma / Q000139:chemically induced / Q000145:classification / Q000473:pathology*; D008647:Mesocricetus; D009602:Nitrosamines; D010190:Pancreatic Neoplasms / Q000139:chemically induced / Q000473:pathology*; D013311:Streptozocin; D013997:Time Factors
chemical_list: D002273:Carcinogens; D009602:Nitrosamines; D013311:Streptozocin; C013622:nitrosobis(2-oxopropyl)amine