Generation of T-cell memory.
Recent studies of T-cell memory have suggested that the persistent presence of the priming antigen is not necessary for maintenance of CD8 memory. Factors contributing to the development of memory from activated T cells remain ill defined but accumulating data suggest that cytokines play a key role in this process. There has also been recent progress in understanding turnover of naive and memory cells in the mouse.
Beverley
P C
PC
Edward Jenner Institute for Vaccine Research, Newbury, Berkshire, UK. peter.beverley@bbsrc.ac.uk
D000818:Animals; D007156:Immunologic Memory; D013601:T-Lymphocytes / Q000276:immunology*