Stimulation of adenosine A1 receptors prevents the EEG arousal due to dopamine D1 receptor activation in rabbits.
The influence of adenosine A1 (N6-cyclopentyladenosine, CPA) and A2 (2-[4-(2-carboxylethyl)phenethylamino]-5'-N-ethylcarboxamido -adenosine hydrochloride, CGS 21680) receptor agonists on SKF 38393-induced electroencephalographic (EEG) arousal was studied in rabbits. While CPA (0.1 mg/kg i.v.) significantly prevented the EEG effects of SKF 38393, CGS 21680 (0.2 mg/kg i.v.) did not affect them. These results demonstrate that adenosine A1 receptors can modulate dopamine D1 receptor-induced EEG arousal and show, for the first time, that adenosine-dopamine interactions are involved in brain functions other than motor activity.
Popoli
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P
Department of Pharmacology, Istituto Superiore di Sanità, Roma, Italy.
Ferré
S
S
Pèzzola
A
A
Reggio
R
R
Scotti de Carolis
A
A
Fuxe
K
K
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology; D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D001143:Arousal / Q000187:drug effects*; D018491:Dopamine Agonists / Q000494:pharmacology; D004347:Drug Interactions; D004569:Electroencephalography; D008297:Male; D010627:Phenethylamines / Q000494:pharmacology; D058906:Purinergic P1 Receptor Agonists; D011817:Rabbits; D017447:Receptors, Dopamine D1 / Q000502:physiology*; D018047:Receptors, Purinergic P1 / Q000502:physiology
D018491:Dopamine Agonists; D010627:Phenethylamines; D058906:Purinergic P1 Receptor Agonists; D017447:Receptors, Dopamine D1; D018047:Receptors, Purinergic P1; C061282:2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine; C048599:N(6)-cyclopentyladenosine; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D000241:Adenosine