title: Sonic hedgehog: making the gradient.
abstract: The amino-terminal peptide of Sonic hedgehog is a cell-tethered molecule, which nevertheless seems to provide a developmental signal that acts at a distance and has different effects depending on its concentration. Recent structural data suggest that zinc-dependent proteolysis may somehow be involved in Sonic hedgehog's function.
authors.affiliation: Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Bumcrot
authors.forename: A P
authors.initials: AP
authors.lastname: McMahon
mesh_terms: D053823:Hedgehog Proteins; D006868:Hydrolysis; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction; D015534:Trans-Activators; D015032:Zinc / Q000378:metabolism
chemical_list: D053823:Hedgehog Proteins; D011506:Proteins; D015534:Trans-Activators; D015032:Zinc