title: Insulin-degrading activity in experimental liver cirrhosis of the rat.
abstract: Liver cirrhosis in man is often associated with hyperinsulinemia but its pathogenesis is still unexplained. To investigate whether insulin degradation is impaired in cirrhotic liver, the specific insulin-degrading enzyme activity (EC 3.4.22.11) was assayed in liver cytosol of rats with CCl4-induced liver cirrhosis. No difference was found between liver cytosol of cirrhotic and control rats. The results show that experimental CCl4-induced liver cirrhosis does not damage the specific insulin-degrading activity and support the hypothesis that impaired hepatic insulin handling is not an important cause of hyperinsulinemia in liver cirrhosis.
authors.affiliation: Department of Internal Medicine, Federico II University, Naples, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Auletta
authors.forename: S
authors.initials: S
authors.lastname: Antoniello
authors.forename: N
authors.initials: N
authors.lastname: Abrescia
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology; D003593:Cytoplasm / Q000201:enzymology / Q000378:metabolism; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D007339:Insulysin / Q000378:metabolism*; D008106:Liver Cirrhosis, Experimental / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D007328:Insulin; D002251:Carbon Tetrachloride; D007339:Insulysin