Chromosomal localization of a new mouse lens opacity gene (lop18)
Examination of mouse strains with a slit lamp and indirect ophthalmoscopy revealed that strain CBA/CaGnLe has a white cataract obvious at weaning age. It soon progresses to a large white nuclear cataract with mild cortical changes. Crosses with C57BL/6J showed that this is inherited as a single recessive fully penetrant gene, which we have designated lop18 (lens opacity 18). Linkage analysis using visible marker T (brachyury), histocompatibility marker H2, and microsatellite markers D17Mit21, D17Mit28, D17Mit38, and D17Mit46 shows that the lop18 gene is located, approximately 16 cM from the centromere on mouse Chromosome 17. It is a likely candidate mutation for the alpha-crystallin (Crya1) gene.
Chang
B
B
The Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Hawes
N L
NL
Smith
R S
RS
Heckenlively
J R
JR
Davisson
M T
MT
Roderick
T H
TH
D000818:Animals; D002386:Cataract / Q000235:genetics* / Q000473:pathology; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D003459:Crystallins / Q000235:genetics; D005260:Female; D005808:Genes, Recessive / Q000235:genetics*; D006183:H-2 Antigens / Q000235:genetics; D007908:Lens, Crystalline / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA
D003459:Crystallins; D006183:H-2 Antigens