Porins: general to specific, native to engineered passive pores.
Several porins from bacterial outer membranes have been crystallized and analyzed by X-ray diffraction, yielding a consistent picture of these membrane-channel proteins. The structures of general and specific channels are in agreement with electrophysiological, diffusional and biochemical data, and provide a starting point for the engineering of other passive membrane pores or porins with new selectivities.
Schulz
G E
GE
Institut für Organische Chemie und Biochemie, Albert-Ludwigs-Univerśität, Albertstrasse 21, D-79104, Freiburg im Breisgau, Germany. schulz@bio5.chemie.uni-freiburg.de
D004058:Diffusion; D015195:Drug Design; D007473:Ion Channels; D008565:Membrane Proteins / Q000737:chemistry*; D018272:Porins / Q000737:chemistry*; D017510:Protein Folding; D017433:Protein Structure, Secondary; D050994:Voltage-Dependent Anion Channels
D007473:Ion Channels; D008565:Membrane Proteins; D018272:Porins; D050994:Voltage-Dependent Anion Channels