title: Antitumoral local effect and metastatic risk of focused extracorporeal pyrotherapy on Dunning R-3327 tumors.
abstract: We evaluated the effect of focused extracorporeal pyrotherapy on local tumor growth and metastatic potential of the Dunning R-3327 tumor inoculated into male Copenhagen Fisher rats, using the highly metastatic MAT Ly Lu cell line in 64 rats and the slightly metastatic G cell line in 60 rats. Five million cells were inoculated subcutaneously into a lower limb and the tumor volume was determined every 48 h. The local effect, the presence of lung and/or lymph node metastases and the spontaneous survival were evaluated in the treated groups (n = 30 for MAT Ly Lu and n = 29 for G) and in the sham control groups (n = 19 for MAT Ly Lu and n = 13 for G) by autopsy of the animals at successive times after treatment. A local effect of treatment was obtained for the two cell lines with complete local cure in 53% of cases. The animals developing metastases were not more numerous in the treated groups than in the control groups. Long-term survivals were obtained in the animals inoculated with the two cell lines. These results suggest that pyrotherapy exerts a local effect on the Dunning R-3327 tumor model without increasing its metastatic potential and allows long-term survivals. Controlled therapeutic trials in human cancers are envisaged.
authors.affiliation: Department of Urology, Centre d'Etude et de Recherche appliquée, CMC de la Porte de Choisy, Paris, France.
authors.forename: N
authors.initials: N
authors.lastname: Bataille
authors.forename: G
authors.initials: G
authors.lastname: Vallancien
authors.forename: D
authors.initials: D
authors.lastname: Chopin
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D006979:Hyperthermia, Induced; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D051381:Rats; D011916:Rats, Inbred F344; D012307:Risk Factors; D012878:Skin Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome; D014407:Tumor Cells, Cultured; D014464:Ultrasonic Therapy / Q000379:methods*; D014463:Ultrasonography