[Microalbuminuria and macrovascular risk factors in insulin-dependent diabetic children].
OBJECTIVE
To investigate the prevalence of microalbuminuria in children and teenagers with IDDM and its relationship with other variables.


METHODS
We studied 160 IDDM children and teenagers with a mean age of 13 +/- 4 years from our endocrine department outpatient clinic. A complete medical history was obtained as well as a fasting blood sample for glycemia, glycosilated hemoglobin and lipid profile and a urine sample for microalbuminuria using laser immunonephelometry.


RESULTS
13 patients (8%) had microalbuminuria (20-200 micrograms/min) and 5 (3%) clinical proteinuria (> 200 micrograms/min). The abnormal excretion was more prevalent in females with the poorest metabolic control, the longest duration of diabetes, and the highest age (13-18 years). The presence of microalbuminuria or clinical proteinuria associated with a more atherogenic risk profile compared to patients with a normal urinary albumin excretion.


CONCLUSIONS
There was a poor metabolic control in our IDDM population. In addition, our current findings in a population with a relatively short duration of their diabetes point out the need to improve an integral management strategy to prevent or delay the late complications associated with IDDM.
Bravo Ríos
E L
EL
Departamento de Endocrinología Pediátrica, Centro Medico Nacional La Razza.
Cardoso Saldãna
G
G
Torres Tamayo
M
M
Lerman Garber
I
I
Zamora González
J
J
García Bulnes
G
G
Mendoza Morfín
F
F
Posadas Romero
C
C
D000293:Adolescent; D000419:Albuminuria / Q000453:epidemiology* / Q000209:etiology; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000652:urine*; D003925:Diabetic Angiopathies / Q000453:epidemiology*; D003928:Diabetic Nephropathies / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D012307:Risk Factors
D001786:Blood Glucose