Closing the gap on DNA ligase.
The crystal structure of T7 DNA ligase complexed with ATP illuminates the mechanism of covalent catalysis by a superfamily of nucleotidyl transferases that includes the ATP-dependent polynucleotide ligases and the GTP-dependent mRNA capping enzymes.
Shuman
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Molecular Biology Program, Sloan-Kettering Institute, New York, NY 10021, USA.
D000255:Adenosine Triphosphate / Q000737:chemistry / Q000378:metabolism; D000595:Amino Acid Sequence; D001665:Binding Sites; D017124:Conserved Sequence / Q000235:genetics; D018360:Crystallography, X-Ray; D000072481:DNA Ligase ATP; D011088:DNA Ligases / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009713:Nucleotidyltransferases / Q000737:chemistry; D011487:Protein Conformation
D000255:Adenosine Triphosphate; D009713:Nucleotidyltransferases; D011088:DNA Ligases; D000072481:DNA Ligase ATP