title: Kanchanamycins, new polyol macrolide antibiotics produced by Streptomyces olivaceus Tü 4018. I. Taxonomy, fermentation, isolation and biological activities.
abstract: The kanchanamycins, a group of novel 36-membered polyol macrolide antibiotics were detected in the culture filtrate and mycelium of Streptomyces olivaceus Tü 4018 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. The compounds show antibacterial and antifungal activities, and are especially effective against Pseudomonas fluorescens. Besides the kanchanamycin complex, strain Tü 4018 produces the 42-membered macrolactones, oasomycin A and desertomycin A, as well as tryptophan-dehydrobutyrine diketopiperazine and daidzein.
authors.affiliation: Biologisches Institut, Universität Tübingen, Germany.
authors.forename: H P
authors.initials: HP
authors.lastname: Fiedler
authors.forename: M
authors.initials: M
authors.lastname: Nega
authors.forename: C
authors.initials: C
authors.lastname: Pfefferle
authors.forename: I
authors.initials: I
authors.lastname: Groth
authors.forename: C
authors.initials: C
authors.lastname: Kempter
authors.forename: H
authors.initials: H
authors.lastname: Stephan
authors.forename: J W
authors.initials: JW
authors.lastname: Metzger
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D007783:Lactones / Q000302:isolation & purification / Q000494:pharmacology; D018942:Macrolides; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D007783:Lactones; D018942:Macrolides; C101773:kanchanamycin A; C101774:kanchanamycin C; C101775:kanchanamycin D