title: Anti-pseudomonal activity of collagen sponge with liposomal polymyxin B.
abstract: An antibiotic delivery system has been developed using collagen sponge with liposome-encapsulated polymyxin B. Superficial, non-lethal infection was produced in mice by injecting Pseudomonas aeruginosa into the skin windows. Wounds were dressed with collagen sponge containing liposomal polymyxin B or containing empty liposomes (with PBS) as a control. Single dose of topically applied collagen sponge with encapsulated polymyxin B decreased bacterial cell number as compared to the control. Finally, after 8 days of experiment, the number of bacterial colonies dropped below 10(4) per biopsy. Presented polymyxin B delivery system offers potential clinical advantages.
authors.affiliation: Department of Microbiology, Military Institute of Hygiene and Epidemiology, Warszawa, Poland.
authors.forename: E A
authors.initials: EA
authors.lastname: Trafny
authors.forename: J
authors.initials: J
authors.lastname: Grzybowski
authors.forename: M
authors.initials: M
authors.lastname: Olszowska-Golec
authors.forename: M
authors.initials: M
authors.lastname: Antos
authors.forename: J
authors.initials: J
authors.lastname: Struzyna
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003094:Collagen; D004337:Drug Carriers; D008081:Liposomes; D051379:Mice; D011112:Polymyxin B / Q000494:pharmacology*; D011549:Pseudomonas / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D008081:Liposomes; D003094:Collagen; D011112:Polymyxin B