Synthesis and antihypertensive activity of novel 1-(4-benzyl-1-phthalazinyl)-pyrazolo[3,4-d]pyrimidines.
Convenient Syntheses of derivatives of the pyrazolo[3,4-d]pyrimidines from 1-(4-benzyl-1-phthalazinyl)-3-amino-4-cyano-5-methylpyrazole (1) and carbon disulphide, aryl isothiocyanates, nitriles or guanidine are described. Derivatives of compound 1 undergo cyclization to the titled ring system by action of dimethylformamide dimethylacetal or hydrogen sulphide followed by treatment with triethylamine. Some of the new compounds were studied as antihypertensive agents.
el-Feky
S A
SA
Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, Zagazig University, Egypt.
Abd el-Samii
Z K
ZK
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013055:Spectrophotometry, Infrared
D000959:Antihypertensive Agents; D011720:Pyrazoles; D011743:Pyrimidines