title: A novel human leukocyte elastase inhibitor from duck egg white.
abstract: A serine proteinase inhibitor (ovomucoid) has been isolated from duck egg white. The duck ovomucoid effectively inhibited HLE, PPE, chymotrypsin, and HCG in a 1:1 molar ratio, and trypsin in a 1:2 molar ratio. Inhibition of human plasmin and porcine pancreatic kallikrein was not observed. The ovomucoid shows equilibrium dissociation constants of 0.002; 2.4; 2.2; 6.1; and 18.0 nM for HLE, PPE, chymotrypsin, trypsin, and HCG, respectively. The molecule of inhibitor can simultaneously bind two trypsin molecules and one molecule of elastase (or chymotrypsin).
authors.affiliation: A.N. Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia.
authors.forename: T A
authors.initials: TA
authors.lastname: Valueva
authors.forename: G V
authors.initials: GV
authors.lastname: Kladnitskaya
authors.forename: V V
authors.initials: VV
authors.lastname: Mosolov
mesh_terms: D000818:Animals; D004372:Ducks; D004529:Egg White / Q000032:analysis*; D006801:Humans; D015843:Serpins / Q000032:analysis*; D013045:Species Specificity
chemical_list: D015843:Serpins