The expanding universe of T-cell subsets: Th1, Th2 and more.
Since their discovery nearly ten years ago, T helper 1 (Th1) and Th2 subsets have been implicated in the regulation of many immune responses. In this article, Tim Mosmann and Subash Sad discuss the increasing number of T-cell subsets defined by cytokine patterns; the differentiation pathways of CD4+ and CD8+ T cells; the contribution of other cell types to these patterns; and the cytokine interactions during infection and pregnancy.
Mosmann
T R
TR
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada. tim.mosmann@ualberta.ca
Sad
S
S
D000818:Animals; D002454:Cell Differentiation; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007376:Interleukin-2 / Q000378:metabolism; D018417:Th1 Cells / Q000502:physiology*; D018418:Th2 Cells / Q000502:physiology*
D016207:Cytokines; D007376:Interleukin-2