title: Phase II trial of edatrexate in patients with metastatic colorectal cancer.
abstract: Edatrexate is an analog of methotrexate which in vitro demonstrated activity against human colon cancer xenografts grown in nude mice. In a phase II trial, 12 patients with metastatic colorectal cancer and no prior chemotherapy were treated with Edatrexate 80 mg/m2/week for an initial period of 8 weeks. No objective responses were observed. Edatrexate is inactive against colon cancer at the dose and schedule used in this trial.
authors.affiliation: Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, 52242, USA.
authors.forename: G H
authors.initials: GH
authors.lastname: Clamon
authors.forename: C E
authors.initials: CE
authors.lastname: Riggs
authors.forename: R
authors.initials: R
authors.lastname: Dreicer
authors.forename: R J
authors.initials: RJ
authors.lastname: Hohl
mesh_terms: D000368:Aged; D000630:Aminopterin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000970:Antineoplastic Agents; C040210:edatrexate; D000630:Aminopterin