The genetic structure of a province as revealed by surnames and HLA genes: potential utility in transplantation policy.
The combined use of surnames, which simulate selectively neutral genetic markers, and HLA genes may constitute a useful tool for the genetic survey of a small area. We found a coincidence between HLA genetic structure and surname "selectively neutral' pattern, in an Italian province, although HLA genes indicate a more pronounced genetic isolation for one particular subregion of the province. The patchiness of HLA allele distribution that is sometimes created by drift and/or selection can be used as the basis both of anthropological and of epidemiological studies. The creation of genetic maps of relatively small areas may also constitute a tool for the selection of bone marrow donors.
Guglielmino
C R
CR
Dipartimento di Genetica e Microbiologia A. Buzzati Traverso Università di Pavia, Italy. GUGLIELMINO@IPVGBE.IGBE.PV.CNR.IT
De Silvestri
A
A
Martinetti
M
M
Daielli
C
C
Salvaneschi
L
L
Cuccia
M
M
D016000:Cluster Analysis; D003241:Consanguinity; D005190:Family; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D005828:Genetics, Population; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007558:Italy / Q000453:epidemiology; D015999:Multivariate Analysis; D010375:Pedigree; D012699:Serology; D012984:Software; D014180:Transplantation
D005819:Genetic Markers; D006680:HLA Antigens