title: Gastrointestinal transit in patients with idiopathic megarectum.
abstract: OBJECTIVE
  In patients with idiopathic megarectum, it is unknown whether abnormality is limited to the dilated large bowel or whether the upper gut is abnormal, as in the various forms of chronic intestinal pseudo-obstruction. This has important implications for treatment, especially surgery.
  
  
  METHODS
  Ten patients (4 females; median age, 18 (range, 17-26) years) with idiopathic megarectum had contrast studies of the upper and lower gut, radioisotope (technetium-99m liquid and indium-111 solid phase) measurement of gastric, small-bowel, and colonic regional transit, and radiopaque marker colonic studies.
  
  
  RESULTS
  All patients had a dilated large bowel. No patient had radiographic evidence of upper gut dilation. Four patients had normal and six patients had abnormally slow gastric emptying. Both the radioisotope scans and radiopaque marker studies showed abnormal colonic transit. Regions of delay corresponded with the region of dilated bowel. Symptoms of abdominal distention and bloating did not correspond to abnormalities of gastric emptying but rather with effectiveness of rectal evacuation.
  
  
  CONCLUSIONS
  Patients with idiopathic megarectum have abnormal colonic transit, delay occurring predominantly in the dilated gut. Marker studies are less sensitive than isotope studies but provide adequate information for clinical purposes. Although motility abnormalities of the upper gut are common, symptoms correlate with large-bowel abnormalities.
authors.affiliation: St. Mark's Hospital, London, United Kingdom.
authors.forename: J M
authors.initials: JM
authors.lastname: Gattuso
authors.forename: M A
authors.initials: MA
authors.lastname: Kamm
authors.forename: G
authors.initials: G
authors.lastname: Morris
authors.forename: K E
authors.initials: KE
authors.lastname: Britton
mesh_terms: D000293:Adolescent; D000328:Adult; D003287:Contrast Media; D004108:Dilatation, Pathologic; D005260:Female; D005746:Gastric Emptying; D005772:Gastrointestinal Transit; D006801:Humans; D008297:Male; D011877:Radionuclide Imaging; D012002:Rectal Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology*
chemical_list: D003287:Contrast Media