Effect of Haemophilus influenzae type b conjugate vaccine in combination with peroral immunization with Escherichia coli on experimental otitis media.
The protective ability of a conjugated Haemophilus influenzae type b vaccine, ACT-HIB, used singly or in combination with orally administered Escherichia coli, was investigated in a rat model for acute otitis media. The humoral response to ACT-HIB was also analyzed. The study demonstrated that ACT-HIB vaccination resulted in a prompt antibody response, and that ACT-HIB was efficient in preventing middle ear infections caused by Haemophilus influenzae type b. The efficiency increased if the vaccine was combined with Escherichia coli. The results suggest that Escherichia coli could possibly be useful in the future as a vaccine vehicle, and since Haemophilus influenzae acute mastoiditis seems to be almost exclusively due to serotype b, the incidence of this infection may be reduced with the conjugated Haemophilus influenzae type b vaccines.
Melhus
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A
Department of Medical Microbiology, Lund University, Malmö General Hospital, Sweden.
Hermansson
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A
Forsgren
A
A
Prellner
K
K
D000208:Acute Disease; D000284:Administration, Oral; D000818:Animals; D004926:Escherichia coli / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000517:prevention & control*; D006192:Haemophilus Infections / Q000517:prevention & control*; D018073:Haemophilus Vaccines / Q000008:administration & dosage* / Q000627:therapeutic use*; D006193:Haemophilus influenzae / Q000472:pathogenicity; D008297:Male; D010033:Otitis Media / Q000209:etiology / Q000276:immunology* / Q000517:prevention & control; D051381:Rats; D017207:Rats, Sprague-Dawley; D014611:Vaccination
D018073:Haemophilus Vaccines