title: IgG1 and IgG2 antibody responses to Plasmodium falciparum exoantigens correlate inversely and positively, respectively, to the number of malaria attacks.
abstract: In Manarintsoa, near Antananarivo, Madagascar, two groups of patients were defined in terms of malaria clinical immune status: Group MA+ consisted of 36 patients who suffered from between one to four malaria attacks (MA) during the 20-week study, and Group MA- who comprised of 48 persons who did not have any malaria attacks during this time. In group MA+, IgM and IgG antibody levels to Plasmodium falciparum exoantigens (E-Ag) were inversely related to the number of malaria attacks. The level of IgM antibodies were significantly higher in group MA+. In contrast, IgG, IgG1, IgG2, IgG3 and IgG4 antibodies to E-Ag were significantly higher in group MA-. The level of IgG1 antibodies was inversely correlated, and IgG2 antibodies were positively correlated to the number of malaria attacks.
authors.affiliation: Département de Parasitologie Mycologie Médicale et Moléculaire, Faculté de Médecine, CNRS EP 78, Université Joseph Fourier-Grenoble I, La Tronche, France.
authors.forename: B F
authors.initials: BF
authors.lastname: Chumpitazi
authors.forename: J P
authors.initials: JP
authors.lastname: Lepers
authors.forename: J
authors.initials: J
authors.lastname: Simon
authors.forename: P
authors.initials: P
authors.lastname: Deloron
mesh_terms: D000293:Adolescent; D000328:Adult; D000913:Antibodies, Protozoan / Q000097:blood*; D000953:Antigens, Protozoan / Q000276:immunology*; D002648:Child; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008137:Longitudinal Studies; D008270:Madagascar / Q000453:epidemiology; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000276:immunology*; D008875:Middle Aged; D015999:Multivariate Analysis; D010507:Periodicity; D015995:Prevalence; D018709:Statistics, Nonparametric
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D007074:Immunoglobulin G