title: Reduction by streptozocin of blood glucose utilization during the appearance of the streptozocin induced early hyperglycaemia in fasting rats.
abstract: During the fasting state, in which the hepatic glycogen storage is almost depleted, streptozocin administration (60 mg/kg, iv) also induces an early hyperglycaemia. It was found that the blood glucose concentration in the hepatic vein was significantly higher than that in the tail vein before and at 4 hours after the injection of the vehicle without streptozocin. However, the blood glucose concentration in the hepatic vein was insignificantly different from that in the tail vein 4 hours after streptozocin administration. The data are interpreted as showing that streptozocin may reduce blood glucose utilization during the period of early hyperglycaemia induced by streptozocin.
authors.affiliation: Department of Pharmacology, National Yang Ming University Taipei, Taiwan, Republic of China.
authors.forename: K K
authors.initials: KK
authors.lastname: Wong
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D005215:Fasting; D006943:Hyperglycemia / Q000139:chemically induced*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D013311:Streptozocin