title: Evolution and the structural domains of proteins.
abstract: Domains are regarded as the basic units of globular proteins and are associated to protein function, folding, and evolution. The occurrence of similar domains in different proteins has led to the proposal of divergent evolution from a common ancestral gene that has been duplicated and fused with a variety of different genes, which suggests that large proteins have been constructed using a modular mechanism in which domains are the building blocks. The appearance of proteins with new or different functions could then arise by exon recombination since these protein coding units frequently correspond to protein structural domains. Some aspects of the evolution of phosphofructokinase are assessed from this standpoint.
authors.affiliation: Departamento de Química, Facultad de Ciencias, Universidad de Chile, Santiago, Chile.
authors.forename: J
authors.initials: J
authors.lastname: Babul
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics; D019143:Evolution, Molecular; D005796:Genes; D008958:Models, Molecular; D005810:Multigene Family; D010732:Phosphofructokinase-1 / Q000235:genetics; D011487:Protein Conformation; D017510:Protein Folding; D017433:Protein Structure, Secondary; D011506:Proteins / Q000235:genetics; D011995:Recombination, Genetic; D013329:Structure-Activity Relationship
chemical_list: D001426:Bacterial Proteins; D011506:Proteins; D010732:Phosphofructokinase-1