Structural and pharmacological aspects of the GABAA receptor: involvement in behavioral pathogenesis.
The gamma-aminobutyric acidA (GABAA) receptor is a complex hetero-oligomeric protein. It is composed of several subunits which assemble to form a functional chloride channel. The precise molecular organization of the receptor is as yet unknown. In the first part, we review recent literature dealing with the molecular and pharmacological aspects of the GABAA receptor, the second part will review some of the pathologies probably associated with gene defects and/or quantitative differential expression of transcripts encoding GABAA receptor subunits.
Clément
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URA-CNRS 1957, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
D000818:Animals; D001519:Behavior / Q000187:drug effects / Q000502:physiology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D018118:Chloride Channels / Q000235:genetics / Q000378:metabolism; D006801:Humans; D011963:Receptors, GABA-A / Q000737:chemistry / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*
D018118:Chloride Channels; D011963:Receptors, GABA-A