Retinoids in patterning: chimeras win by a knockout.
Recent studies on the regenerating newt limb, using cells transfected with chimeric retinoic acid receptors that can be activated by thyroid hormone, have provided unique insights into the function of specific retinoic acid receptor isoforms.
Maden
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Developmental Biology Research Centre, King's College, London, UK.
D000818:Animals; D051379:Mice; D018345:Mice, Knockout / Q000196:embryology / Q000378:metabolism; D018168:Receptors, Retinoic Acid / Q000235:genetics / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D012176:Retinoids / Q000378:metabolism; D014212:Tretinoin / Q000378:metabolism
D018168:Receptors, Retinoic Acid; D011993:Recombinant Fusion Proteins; D012176:Retinoids; D014212:Tretinoin