Effect of aspirin-dipyridamole and heparin and their combination on venous thrombosis in hypercoagulable or thrombotic animals.
Epsilon-amino-caproic acid (EACA) induces a clinically-useful anti-haemorrhagic, mildly thrombotic state while ellagic acid (EA) induces a severe hypercoagulable one. Reversal of these states may on occasion be necessary. The effectiveness of the antiplatelet drugs, aspirin and dipyridamole (ASA/D), in reducing thrombus weight was studied in normocoagulable animals and animals made hypercoagulable with EACA (333mg/kg) or EA (1.2mg/kg). Heparin (114iu/kg) was tested in the EACA group, both alone and in combination with ASA/D. Thrombogenicity was measured by weight formed on intravenous platinum wire in one hour. In normocoagulable animals, ASA/D reduced thrombus by 32%. Ellagic acid trebled mean thrombus weight and ASA/D reduced this by 49%, but did not restore normality. EACA increased mean thrombosis by one sixth. Treatment with heparin reduced this by 48% to a level well below that of untreated animals. Addition of a single dose of aspirin/dipyridamole to the heparin regime, reduced thrombosis by a further 31%, reaching to 21% of control thrombus. The results were statistically significant. Kaolin-activated blood clotting time was shortened by EA, but EACA had little effect on it, while ASA/D slightly and heparin markedly lengthened it.
Iomhair
M M
MM
Department of Experimental Medicine, University College Galway, Ireland.
Lavelle
S M
SM
D000818:Animals; D001241:Aspirin / Q000008:administration & dosage*; D001777:Blood Coagulation / Q000187:drug effects; D004176:Dipyridamole / Q000008:administration & dosage*; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D004610:Ellagic Acid / Q000633:toxicity; D005260:Female; D006493:Heparin / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013927:Thrombosis / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D014682:Vena Cava, Inferior / Q000473:pathology*
D004338:Drug Combinations; D010975:Platelet Aggregation Inhibitors; D004610:Ellagic Acid; D004176:Dipyridamole; D006493:Heparin; D001241:Aspirin