Vaccines for gonorrhea: where are we on the curve?
Human antibodies that bind the gonococcal outer membrane modulate gonorrheal transmission and disease. The effects of antibody binding can favor either the host or the bacteria, and depend on the antigen involved. An effective gonococcal vaccine is feasible, but only by the careful selection and formulation of gonococcal antigens that elicit only host-protective antibodies.
Blake
M S
MS
University of Iowa, College of Medicine, Department of Microbiology, Iowa City, Iowa, USA.
Wetzler
L M
LM
D001428:Bacterial Vaccines; D002986:Clinical Trials as Topic; D006069:Gonorrhea / Q000517:prevention & control*; D006801:Humans; D009344:Neisseria gonorrhoeae / Q000737:chemistry / Q000276:immunology
D001428:Bacterial Vaccines