title: Scutione, a new bioactive norquinonemethide triterpene from Maytenus scutioides (Celastraceae).
abstract: Scutione (1), a new norquinonemethide triterpene with a netzahualcoyene type skeleton, has been isolated from the root bark of Maytenus scutioides (Celastraceae) by bioactivity-directed fractionation. The structure of 1 has been elucidated by means of 1H and 13C NMR spectroscopic studies, including 1H-13C heteronuclear correlation (HETCOR), a long-range correlation spectrum with inverse detection (HMBC) and ROESY experiments. Compound 1 showed antibiotic activity against Gram-positive bacteria and modest cytotoxic activity against HeLa, Hep-2 and Vero cell lines. Fluoride derivatives 2-4 were prepared and assayed for bioactivity, where 2 showed slight improvement of the cytotoxic potency.
authors.affiliation: Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, Tenerife, Canary Islands, Spain.
authors.forename: A G
authors.initials: AG
authors.lastname: González
authors.forename: N L
authors.initials: NL
authors.lastname: Alvarenga
authors.forename: A G
authors.initials: AG
authors.lastname: Ravelo
authors.forename: I L
authors.initials: IL
authors.lastname: Bazzocchi
authors.forename: E A
authors.initials: EA
authors.lastname: Ferro
authors.forename: A G
authors.initials: AG
authors.lastname: Navarro
authors.forename: L M
authors.initials: LM
authors.lastname: Moujir
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D006367:HeLa Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D010944:Plants / Q000737:chemistry; D013057:Spectrum Analysis; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014709:Vero Cells
chemical_list: D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C103715:scutione