Optimal dose of enterococcal preparation (FK-23) supplemented perorally for stimulation of leukocyte reconstitution in dogs treated with cyclophosphamide.
Optimal doses of orally supplemented heat-killed Enterococcus faecalis FK-23 preparation (FK-23) were evaluated in dogs treated with cyclophosphamide (CY). Leukocyte reconstitution was stimulated by the supplement of 100 mg/kg of FK-23 through an induction of neutrophilia, and the treatment of 10 mg/kg of FK-23 induced mild neutrophilia in dogs tested. However, the reconstitution was not stimulated by the treatment of 200 or 400 mg/kg of the drug. Although the effects of FK-23 appeared to be milder than those of recombinant human granulocyte colony stimulating factor (rhG-CSF), there was no significant difference in the leukocyte reconstitution between the two substances. An appropriate dose of FK-23 is 100 mg/kg for augmentation of leukocyte reconstituting capacity in dogs treated with CY.
Kanasugi
H
H
Faculty of Agriculture, Miyazaki University, Japan.
Hasegawa
T
T
Yamamoto
T
T
Abe
S
S
Yamaguchi
H
H
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000284:Administration, Oral; D000818:Animals; D003520:Cyclophosphamide / Q000633:toxicity*; D004285:Dogs; D013293:Enterococcus faecalis; D005527:Food, Fortified; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D006801:Humans; D007962:Leukocytes / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D009504:Neutrophils / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D011994:Recombinant Proteins / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D003520:Cyclophosphamide