title: Quinidine-induced pigmentation.
abstract: Antimalarial agents have long been known to cause a variety of pigmentary disturbances. Quinidine, a cincha alkaloid and D-isomer of quinine, is widely used for the treatment of ventricular arrhythmias. A paucity of literature, however, exists concerning quinidine-associated hyperpigmentation. We describe a case of focal ceruloderma we believe to be secondary to quinidine therapy.
authors.affiliation: Department of Dermatology, Cleveland Clinic Foundation, Ohio 44195, USA.
authors.forename: E A
authors.initials: EA
authors.lastname: Conroy
authors.forename: M O
authors.initials: MO
authors.lastname: Liranzo
authors.forename: J
authors.initials: J
authors.lastname: McMahon
authors.forename: W D
authors.initials: WD
authors.lastname: Steck
authors.forename: R J
authors.initials: RJ
authors.lastname: Tuthill
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005533:Foot Dermatoses / Q000139:chemically induced / Q000473:pathology; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced* / Q000473:pathology; D007501:Iron / Q000032:analysis; D007868:Leg Dermatoses / Q000139:chemically induced / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009260:Nail Diseases / Q000139:chemically induced / Q000473:pathology; D011802:Quinidine / Q000008:administration & dosage / Q000009:adverse effects*; D017180:Tachycardia, Ventricular / Q000188:drug therapy; D014034:Toes / Q000473:pathology
chemical_list: D000889:Anti-Arrhythmia Agents; D007501:Iron; D011802:Quinidine