title: Membrane-bound tyrosine aminopeptidase activities in the rat brain throughout the estrous cycle.
abstract: Puromycin sensitive and insensitive membrane-bound aminopeptidase activity levels during the estrous cycle in several brain areas have been described in this research. We have found the highest aminopeptidase M activity levels during the proetrous stage in the hypothalamus, the amygdala and the pituitary gland. Since this enzyme has been involved in opioid peptide metabolism, it is suggested that aminopeptidase M could play a part in the decrease in the inhibitory influence of the endogenous opioids peptides that participate in the LH surge.
authors.affiliation: Department of Physiology, Medical School, University of the Basque Country, Bilbao, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: de Gandarias
authors.forename: J
authors.initials: J
authors.lastname: Irazusta
authors.forename: D
authors.initials: D
authors.lastname: Fernández
authors.forename: M
authors.initials: M
authors.lastname: Gallego
authors.forename: M
authors.initials: M
authors.lastname: Silió
authors.forename: L
authors.initials: L
authors.lastname: Casis
mesh_terms: D000626:Aminopeptidases / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000502:physiology; D002462:Cell Membrane / Q000201:enzymology; D004971:Estrus; D005260:Female; D011691:Puromycin / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D011691:Puromycin; D000626:Aminopeptidases