Vertebrate neural progenitor cells: subtypes and regulation.
Several advances have been made recently in characterizing neural progenitor cells. In vertebrates, multipotential stem cells have been demonstrated in the developing forebrain both in vitro and in vivo, and a class of stem cells has been identified in the adult CNS. Factors that regulate the proliferation and differentiation of subtypes of neural progenitor cells have also been described. In invertebrates, progress has been made in identifying genes involved in neural progenitor cell specification, cell-fate choices and regulation.
Temple
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Department of Pharmacology and Neuroscience, Albany Medical College, New York 12208, USA. Sally_Temple@ccgateway.amc.edu
Qian
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D000818:Animals; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology*; D014714:Vertebrates / Q000254:growth & development*