Effect of flow on the resistance of modelled femoral artery stenoses.
An accurate model of the pressure-flow relationship of a stenosis is necessary for the correct interpretation of haemodynamic measurements. Modelled femoral artery stenoses were tested in vitro and the pressure drop: flow ratio (resistance) was most accurately represented by a fixed component (Rf) combined with a variable component (Rv) that increased linearly with flow (Q) such that Rv = SvQ. For stenoses of 68-94 per cent area, Rf increased from 3.2 to 77.7 milliperipheral resistance units (mPRU), while Sv increased from 0.009 to 0.578 mPRU ml-1 min and Rv was dominant for physiological flow rates. It was concluded that the approximation of a significant stenosis to a fixed resistance is incorrect.
Dodds
S R
SR
Department of Vascular Surgery, Royal South Hants Hospital, Southampton, UK.
Bourne
N K
NK
Chant
A D
AD
D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000502:physiology; D003251:Constriction, Pathologic / Q000503:physiopathology; D005263:Femoral Artery / Q000503:physiopathology*; D006801:Humans; D008954:Models, Biological; D016491:Peripheral Vascular Diseases / Q000473:pathology / Q000503:physiopathology; D014655:Vascular Resistance / Q000502:physiology*