Strength in numbers: non-natural polyvalent carbohydrate derivatives.
Many processes mediated by protein-carbohydrate interactions involve multivalent low-affinity binding, which is inherently difficult to study. New structural templates for the generation of multivalent carbohydrate displays have recently been developed, and tailored multivalent saccharide derivatives can now be used to study and modulate a wide variety of biological recognition events.
Kiessling
L L
LL
Department of Chemistry, 1101 University Avenue, University of Wisconsin-Madison, Madison, WI 53706, USA.
Pohl
N L
NL
D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000737:chemistry*; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism
D002241:Carbohydrates; D011506:Proteins