Versatile molecular glue. Transcriptional control.
CBP and p300 are versatile coactivators that physically connect many DNA-binding factors to the basal transcription machinery. Phosphorylation by cyclin-dependent or signal-induced protein kinases may regulate their function.
Janknecht
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R
The Salk Institute Molecular Biology and Virology Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
Hunter
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T
D000123:Acetyltransferases; D000818:Animals; D050882:CREB-Binding Protein; D018797:Cell Cycle Proteins / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D051548:Histone Acetyltransferases; D009687:Nuclear Proteins / Q000378:metabolism*; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism; D015534:Trans-Activators; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic; D050880:p300-CBP Transcription Factors; D000099224:p300-CBP-Associated Factor
D000123:Acetyltransferases; D050882:CREB-Binding Protein; D018797:Cell Cycle Proteins; D000242:Cyclic AMP; D051548:Histone Acetyltransferases; D009687:Nuclear Proteins; D011494:Protein Kinases; D015534:Trans-Activators; D014157:Transcription Factors; D050880:p300-CBP Transcription Factors; D000099224:p300-CBP-Associated Factor