IL4 and IL13 receptors share the gamma c chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells.
IL13 induces the same biological effects as IL4 in normal human B cells. We show that as in the IL4R complex, both IL4R alpha and IL2R gamma c are components of the IL13R and that both cytokines induced STAT6, STAT3 and STAT5 activation in B cells. In spite of this similar downstream signalling, IL4 and IL13 used a different set of Janus kinases: IL13 is unable to activate JAK1 and JAK3.
Rolling
C
C
INSERM U131, Institut Paris-Sud sur les Cytokines, Clamart, France.
Treton
D
D
Pellegrini
S
S
Galanaud
P
P
Richard
Y
Y
D015703:Antigens, CD / Q000737:chemistry / Q000378:metabolism*; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D002648:Child; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006801:Humans; D007127:Immunoglobulin Constant Regions / Q000276:immunology; D007142:Immunoglobulin gamma-Chains / Q000276:immunology; D018793:Interleukin-13 / Q000378:metabolism; D053661:Interleukin-13 Receptor alpha1 Subunit; D015847:Interleukin-4 / Q000378:metabolism; D053613:Janus Kinase 1; D053616:Janus Kinase 3; D008894:Milk Proteins; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D018123:Receptors, Interleukin / Q000737:chemistry / Q000378:metabolism*; D053660:Receptors, Interleukin-13; D015375:Receptors, Interleukin-2 / Q000276:immunology; D019948:Receptors, Interleukin-4; D011994:Recombinant Proteins / Q000378:metabolism; D050796:STAT3 Transcription Factor; D050799:STAT5 Transcription Factor; D050800:STAT6 Transcription Factor; D013997:Time Factors; D015534:Trans-Activators / Q000378:metabolism*; D014443:Tyrosine / Q000378:metabolism
D015703:Antigens, CD; D004268:DNA-Binding Proteins; C508181:IL13RA1 protein, human; D007127:Immunoglobulin Constant Regions; D007142:Immunoglobulin gamma-Chains; D018793:Interleukin-13; D053661:Interleukin-13 Receptor alpha1 Subunit; D008894:Milk Proteins; D018123:Receptors, Interleukin; D053660:Receptors, Interleukin-13; D015375:Receptors, Interleukin-2; D019948:Receptors, Interleukin-4; D011994:Recombinant Proteins; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D050799:STAT5 Transcription Factor; D050800:STAT6 Transcription Factor; C494101:STAT6 protein, human; D015534:Trans-Activators; D015847:Interleukin-4; D014443:Tyrosine; D011505:Protein-Tyrosine Kinases; C507904:JAK1 protein, human; C507933:JAK3 protein, human; D053613:Janus Kinase 1; D053616:Janus Kinase 3