Clozapine therapy in patients with neurologic illness.
OBJECTIVE
This review will analyze the use of clozapine in patients with neurologic illness.


METHODS
A review of the literature was performed. Attention is focused particularly on patients with seizure disorder, head injury, mental retardation, Parkinson's disease, Huntington's disease, tardive dyskinesia, and selected other neurological disorders.


RESULTS
This review discusses clinical difficulties/issues associated with clozapine therapy in patients with a variety of neurological disorders.


CONCLUSIONS
Although clozapine therapy should be reserved for those patients who are refractory to conventional psychotropic medications, when used appropriately it may offer a safe and effective way of improving quality of life for patients with behavioral symptoms and neurologic illness.
Sajatovic
M
M
Cleveland Veterans Administration Medical Center, Brecksville, OH 44141, USA.
Ramirez
L
L
D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003024:Clozapine / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D009422:Nervous System Diseases / Q000188:drug therapy* / Q000209:etiology; D011788:Quality of Life; D016896:Treatment Outcome
D014150:Antipsychotic Agents; D003024:Clozapine