title: Poliovirus: new insights from an old paradigm.
abstract: A combination of structural and genetic studies of poliovirus suggests that the final stages of viral assembly lock the virus in a metastable structure primed to undergo the receptor-catalyzed conformational changes required for cell entry. Future studies promise to provide detailed insights into the conformational dynamics of the virion during its life cycle.
authors.affiliation: Committee for Higher Degrees in Biophysics, Harvard University, Cambridge, MA 02138, USA.
authors.forename: M W
authors.initials: MW
authors.lastname: Wien
authors.forename: M
authors.initials: M
authors.lastname: Chow
authors.forename: J M
authors.initials: JM
authors.lastname: Hogle
mesh_terms: D008565:Membrane Proteins; D008958:Models, Molecular; D015394:Molecular Structure; D017955:Poliovirus / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D012367:RNA, Viral / Q000235:genetics; D011991:Receptors, Virus / Q000502:physiology; D013329:Structure-Activity Relationship
chemical_list: D008565:Membrane Proteins; D012367:RNA, Viral; D011991:Receptors, Virus; C066100:poliovirus receptor