title: Acute encephalopathy attributed to 5-FU.
abstract: Acute encephalopathy attributable to 5-fluorouracil (5-FU) is rare. A patient experienced this reaction associated with a continuous 5-FU infusion. The etiology of the event remains uncertain, but it is generally reversible and does not preclude retreatment with 5-FU at reduced dosages. Steroids and thiamine may expedite neurologic recovery.
authors.affiliation: Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Langer
authors.forename: A
authors.initials: A
authors.lastname: Hageboutros
authors.forename: D D
authors.initials: DD
authors.lastname: Kloth
authors.forename: D
authors.initials: D
authors.lastname: Roby
authors.forename: A H
authors.initials: AH
authors.lastname: Shaer
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D001921:Brain / Q000187:drug effects*; D001927:Brain Diseases / Q000139:chemically induced; D002526:Cerebellar Diseases / Q000139:chemically induced; D002531:Cerebellum / Q000187:drug effects; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil