Severe acute graft-versus-host disease of conjunctivae after allogeneic blood progenitor cell infusion.
A 37-year-old woman with Philadelphia chromosome-positive acute lymphoblastic leukemia received allogeneic bone marrow transplants after first and second relapses from different HLA-identical brothers. After a third relapse, blood progenitor cells from one of the brothers were infused after six doses of cytarabine 1.5 g/m2 in an attempt to induce a graft-versus-leukemia effect. Seven weeks after the infusion, the patient developed delayed but severe acute graft-versus-host disease (GVHD) including the unusual manifestation of conjunctival involvement.
Spiro
T P
TP
Department of Medicine, Ireland Cancer Center; Cleveland, OH, USA.
O'Day
D G
DG
Bardenstein
D
D
Cooper
B W
BW
Lazarus
H M
HM
D000208:Acute Disease; D000328:Adult; D003229:Conjunctival Diseases / Q000209:etiology*; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D014184:Transplantation, Homologous