Alloxan stimulation and subsequent inhibition of insulin release from in situ perfused rat pancreas.
In the performed experiment the effect of alloxan on insulin secretion by in situ perfused rat pancreas was determined. It was found that alloxan added to the perfusion medium results in a sudden, short-term release of insulin. This effect is independent on the presence of glucose (6.66 mmol/l) in the perfusion medium. Furthermore, it was observed that glucose at 16.66 mmol/l concentration after alloxan perfusion does not stimulate insulin secretion.
Kliber
A
A
Department of Animal Physiology and Biochemistry, Academy of Agriculture, Poznań, Poland.
Szkudelski
T
T
Chichłowska
J
J
D000496:Alloxan / Q000494:pharmacology*; D000818:Animals; D005947:Glucose / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D007328:Insulin; D000496:Alloxan; D005947:Glucose