[An experimental study of the immunogenic and protective properties of Coxiella burnetii strain M-44 and a live enteral vaccine against Q fever].
High effectiveness of C.burnetii strain M-44 was confirmed in experimental studies on subcutaneously immunized guinea pigs ¿correction of pig] after their intratracheal infection with the virulent culture of the infective agent. The study revealed that the dose necessary for the enteral immunization of guinea pigs and monkeys was 10(4.8) -- 10(5.0) times less than that needed for the oral immunization of the animals. Live enteral vaccine obtained on the basis of this strain possessed sufficiently pronounced immunogenic and protective properties, protecting 75% of immunized monkeys from subcutaneous infection with C.burnetii virulent culture.
Mikhaĭlov
V V
VV
Virological Center of the Research Institute of Microbiology, Sergiev Posad, Moscow Region, Russia.
Vorob'ev
A A
AA
Makhlaĭ
A A
AA
Khaltaeva
G G
GG
Suvorova
T A
TA
Krasnianskiĭ
V P
VP
Iakovlev
E A
EA
Pashanin
Iu G
IuG
Dykanov
G A
GA
Podkuĭko
V N
VN
Lebedinskaia
E V
EV
D000818:Animals; D016997:Coxiella burnetii / Q000276:immunology* / Q000472:pathogenicity; D004306:Dose-Response Relationship, Immunologic; D006168:Guinea Pigs; D007114:Immunization / Q000379:methods; D008252:Macaca fascicularis; D010215:Papio; D011778:Q Fever / Q000276:immunology / Q000517:prevention & control*; D051381:Rats; D012290:Rickettsial Vaccines / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000276:immunology; D014774:Virulence
D012290:Rickettsial Vaccines; D014613:Vaccines, Attenuated