Double agent: translational regulation by a transcription factor.
The homeodomain protein bicoid activates transcription of several target genes by binding to target sequences in DNA. It has recently been shown that bicoid is also an RNA-binding protein that regulates the translation of caudal mRNA. Several ways for a protein to acquire dual functions can be imagined.
Mayfield
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Department of Cell Biology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
D029721:Drosophila Proteins; D005786:Gene Expression Regulation; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D007301:Insect Hormones / Q000378:metabolism; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D015534:Trans-Activators; D014157:Transcription Factors / Q000378:metabolism*
D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D007301:Insect Hormones; D012333:RNA, Messenger; D015534:Trans-Activators; D014157:Transcription Factors; C056478:bcd protein, Drosophila; C084564:cad protein, Drosophila