Autopsy case of colocalized tumors of hepatocellular carcinoma and malignant lymphoma.
We present a rare case of colocalized tumors of hepatocellular carcinoma (HCC) and malignant lymphoma in the liver and bone marrow. A 64-year-old man with hepatitis B virus (HBV)-induced cirrhosis was admitted after detection of elevated serum alpha-fetoprotein level. He was diagnosed as having HCC and treated with chemotherapy and radiotherapy, but the size of the tumors did not diminish. After 11 months' hospitalization, he died due to rupture of esophageal varices. Autopsy revealed two heterogenic malignant tumors, HCC and malignant lymphoma (B cell type), in the liver. These tumors showed colocalization in the liver and bone marrow. The carcinogenetic process of colocalized tumors of HCC and lymphoma was not clarified, but the possibility that persistent HBV infection play a role in promoting hepatocarcinogenic and hematopoietic tumor growths in the reticuloendothelial organs could not be excluded.
Shikuwa
S
S
Department of Pathology, Nagasaki University School of Medicine, Japan.
Ito
M
M
Nakashima
M
M
Hamasaki
K
K
Naito
S
S
Sekine
I
I
Fujii
H
H
D001344:Autopsy; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000473:pathology*; D002908:Chronic Disease; D017809:Fatal Outcome; D006509:Hepatitis B / Q000150:complications*; D006801:Humans; D007124:Immunoenzyme Techniques; D008113:Liver Neoplasms / Q000150:complications / Q000473:pathology*; D016393:Lymphoma, B-Cell / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000473:pathology*