title: Malabsorption and wasting in AIDS patients with microsporidia and pathogen-negative diarrhea.
abstract: OBJECTIVE
  To define the clinical syndrome, nutritional status and malabsorptive status in patients with HIV and chronic diarrhea and either microsporidia or no identified pathogen.
  
  
  METHODS
  HIV-positive patients from an urban, hospital-based infectious disease clinic with chronic diarrhea who had undergone exhaustive gastrointestinal and stool studies for enteric pathogens and were found to have either microsporidia or no pathogen.
  
  
  METHODS
  Patients were evaluated for clinical history, physical, body composition, nutritional and malabsorptive studies including D-xylose, Schilling test, determinations of 24 h stool fat, weight and nitrogen, and 24 h urea nitrogen.
  
  
  RESULTS
  Ten patients with microsporidia were studied, four of whom were infected with Septata intestinalis, six with Enterocytozoon bieneusi; nine patients had no identified pathogen. Patients in both groups were comparable in stage of HIV disease, and demonstrated abnormal nutritional status and malabsorptive parameters. Patients with no pathogen had significantly longer duration of symptoms prior to presentation; however, patients with microsporidia had significantly greater malabsorption of fat, D-xylose, vitamin B12, and significantly lower serum levels of zinc. Nutritional status and malabsorption were similarly depressed in patients infected with either species of microsporidia.
  
  
  CONCLUSIONS
  HIV-infected patients with chronic diarrhea associated with either microsporidial infection or with no identified pathogen had abnormal parameters of absorption and malnutrition, and those infected with microsporidia demonstrated more severe malabsorption.
authors.affiliation: Division of Infectious Diseases, New England Deaconess Hospital, Boston, MA 02215, USA.
authors.forename: B B
authors.initials: BB
authors.lastname: Lambl
authors.forename: M
authors.initials: M
authors.lastname: Federman
authors.forename: D
authors.initials: D
authors.lastname: Pleskow
authors.forename: C A
authors.initials: CA
authors.lastname: Wanke
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000378:metabolism* / Q000469:parasitology; D000328:Adult; D000818:Animals; D018791:CD4 Lymphocyte Count; D003967:Diarrhea / Q000209:etiology*; D004041:Dietary Fats / Q000378:metabolism; D019247:HIV Wasting Syndrome / Q000150:complications* / Q000209:etiology* / Q000469:parasitology; D006801:Humans; D008286:Malabsorption Syndromes / Q000150:complications* / Q000209:etiology* / Q000821:virology; D008297:Male; D016816:Microsporida; D011528:Protozoan Infections / Q000150:complications* / Q000209:etiology* / Q000378:metabolism; D014805:Vitamin B 12 / Q000378:metabolism; D014994:Xylose / Q000378:metabolism; D015032:Zinc / Q000378:metabolism
chemical_list: D004041:Dietary Fats; D014994:Xylose; D015032:Zinc; D014805:Vitamin B 12