title: Epigenetic phase variation of the pap operon in Escherichia coli.
abstract: Expression of the pyelonephritis-associated pilus (pap) operon in Escherichia coli is regulated by a complex epigenetic phase-variation mechanism involving the formation of differential DNA-methylation patterns. This review discusses how DNA-methylation patterns are formed by protein-DNA interactions and how methylation patterns, in turn, control pap gene expression.
authors.affiliation: Dept of Pathology, Health Sciences Center, Salt Lake City, UT 84132, USA.
authors.forename: M
authors.initials: M
authors.lastname: van der Woude
authors.forename: B
authors.initials: B
authors.lastname: Braaten
authors.forename: D
authors.initials: D
authors.lastname: Low
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D004269:DNA, Bacterial / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics*; D010861:Fimbriae, Bacterial / Q000737:chemistry*; D005544:Forecasting; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics*; D008745:Methylation; D008958:Models, Molecular; D009876:Operon / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial