title: Lepidic intrapulmonary growth of malignant mesothelioma presenting as recurrent hydropneumothorax.
abstract: We report a case of malignant mesothelioma with unusual clinical and histological findings. The patient presented with recurrent hydropneumothorax and minimal pleural thickening on chest computed tomography (CT). Histologically, the pleura was involved by the malignant mesothelioma, albeit to a limited degree. Unexpectedly, the lung parenchyma from two different lobes showed focal nests of mesothelioma cells filling the alveolar spaces and growing on the luminal surface of the alveolar septa, closely resembling the multicentric growth pattern of bronchioloalveolar adenocarcinoma. Immunohistochemical and ultrastructural studies confirmed that the pulmonary lesions were an extension of the malignant mesothelioma. This case illustrates clinically, the importance of a high index of suspicion for malignancy in older patients with unexplained recurrent hydropneumothorax; and histologically the potential of malignant mesothelioma to invade the lung at an early stage of growth.
authors.affiliation: Department of Pathology and Laboratory Medicine, Hospital of University of Pennsylvania, Philadelphia, USA.
authors.forename: H
authors.initials: H
authors.lastname: Wu
authors.forename: G
authors.initials: G
authors.lastname: Tino
authors.forename: F H
authors.initials: FH
authors.lastname: Gannon
authors.forename: L R
authors.initials: LR
authors.lastname: Kaiser
authors.forename: G G
authors.initials: GG
authors.lastname: Pietra
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D006801:Humans; D006872:Hydropneumothorax / Q000175:diagnosis*; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008654:Mesothelioma / Q000175:diagnosis / Q000473:pathology*; D010997:Pleural Neoplasms / Q000175:diagnosis / Q000473:pathology*; D012008:Recurrence