title: Early bactericidal activity of rifabutin versus that of placebo in treatment of disseminated Mycobacterium avium complex bacteremia in AIDS patients.
abstract: Rifabutin, 600 mg/day, was compared with a placebo in the early treatment of culture-proven Mycobacterium avium bacteremia in patients with AIDS. Following 14 days' treatment, bacteriological success, defined as a negative culture or a reduction in the number of CFU of M. avium organisms per milliliter of blood by a factor of > or = 0.5 log from the baseline, was observed in 7 of 10 (70%) evaluable rifabutin patients and in 1 of 13 (8%) evaluable placebo patients (P = 0.002). Rifabutin is active against M. avium as a single agent and can make a significant contribution to combination regimens for the treatment of disseminated M. avium infection in AIDS patients.
authors.affiliation: Groupe Hospitalier Pitié Salpêtrière, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Dautzenberg
authors.forename: P
authors.initials: P
authors.lastname: Castellani
authors.forename: J L
authors.initials: JL
authors.lastname: Pellegrin
authors.forename: D
authors.initials: D
authors.lastname: Vittecoq
authors.forename: C
authors.initials: C
authors.lastname: Truffot-Pernot
authors.forename: N
authors.initials: N
authors.lastname: Pirotta
authors.forename: D
authors.initials: D
authors.lastname: Sassella
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000382:microbiology; D000284:Administration, Oral; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015269:Mycobacterium avium Complex; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy*; D010919:Placebos; D017828:Rifabutin / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D010919:Placebos; D017828:Rifabutin