Immunogenetics of HTLV-I/II and associated diseases.
The ethnic background of human T-lymphotropic virus types I and II (HTLV-I/II) infections and associated diseases was investigated in association with human leukocyte antigens (HLA) (alleles) and haplotypes. Japanese HTLV-I carriers were characterized by two categories of HLA class I antigens (A24, A26, B7, B61, Cw1, and Cw7) and class II alleles (DRB1 *0101, 0803, 1403, 1501, and 1502 and DQB1 *0303, 0501, and 0601); one category was associated with adult T-cell leukemia (ATL) patients and the other with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. The ATL-associated haplotypes had unique DRB1-DQB1 alleles (0901-0303, 1501-0602, 1401-0503), which were correlated with a low immune responsiveness to HTLV-I, while the HAM/TSP haplotypes had different DRB1-DQB1 alleles (0101-0501, 0803-0601, 1502-0601), which were correlated with a high immune responsiveness to HTLV-I. Both ATL- and HAM/TSP-associated haplotypes were found among HTLV-I carriers and the patients from other ethnic groups (Jamaican blacks, Andes natives, South American mestizos, and Mashhadi Jews). HLA haplotypes of HTLV-II carriers were different from those of HTLV-I carriers among South American natives. These results suggested that HTLV-I/II infections and the associated diseases might be determined by immunogenetic factors segregated with HLA alleles and haplotypes.
Sonoda
S
S
Department of Virology, Faculty of Medicine, Kagoshima University, Japan.
Fujiyoshi
T
T
Yashiki
S
S
D002353:Carrier State; D015490:HTLV-I Infections / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D015491:HTLV-II Infections / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D006239:Haplotypes / Q000235:genetics / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000032:analysis / Q000235:genetics / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000032:analysis / Q000235:genetics / Q000276:immunology; D006801:Humans; D007198:Indians, North American / Q000235:genetics; D007563:Jamaica; D007564:Japan; D007585:Jews / Q000235:genetics; D015458:Leukemia, T-Cell / Q000208:ethnology / Q000235:genetics*; D015493:Paraparesis, Tropical Spastic / Q000208:ethnology / Q000235:genetics; D013020:South America
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II