title: Measurement of spin-lattice relaxation times with FLASH for dynamic MRI of the breast.
abstract: Using a variable flip angle gradient refocused imaging technique, dynamic quantitative T1 relaxation maps acquired before and after the administration of a gadolinium contrast bolus enable the concentration-time curve of the paramagnetic agent in breast tissue to be calculated. This imaging technique has the aim of improving the diagnostic accuracy of MR mammography. Measurements with phantoms of calibrated T1 values have been carried out to investigate the accuracy of the method, with particular reference to errors caused by incomplete spoiling of residual transverse magnetization and inaccurate radio frequency (RF) flip-angle settings. A clinical example is presented. The method has potential use for any patient study which necessitates rapid quantitation of changing in vivo T1 values as a result of contrast agent injection.
authors.affiliation: Department of Bio-Medical Physics, University of Aberdeen, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Brookes
authors.forename: T W
authors.initials: TW
authors.lastname: Redpath
authors.forename: F J
authors.initials: FJ
authors.lastname: Gilbert
authors.forename: G
authors.initials: G
authors.lastname: Needham
authors.forename: A D
authors.initials: AD
authors.lastname: Murray
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008327:Mammography / Q000379:methods; D008875:Middle Aged; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D019047:Phantoms, Imaging; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA