title: [Relationship between exposure to environmental toxins and motor neuron disease: a case report].
abstract: A case is reported of amyotrophic lateral sclerosis with occupational exposure to solvents and metals. The environmental toxin theory of motorneuron disease, including aspects of epidemiological, clinical, experimental and individual susceptibility is discussed. An overall evaluation of animal and human data was made using a methodological approach developed by the International Agency for Research on Cancer and a Scandinavian group of experts. It is concluded that there is a probable linkage between metals/solvents exposure and motorneuron disease.
authors.affiliation: Dipartimento di Scienze Neurologiche, Università La Sapienza, Roma.
authors.forename: N
authors.initials: N
authors.lastname: Vanacore
authors.forename: L
authors.initials: L
authors.lastname: Corsi
authors.forename: E
authors.initials: E
authors.lastname: Fabrizio
authors.forename: V
authors.initials: V
authors.lastname: Bonifati
authors.forename: G
authors.initials: G
authors.lastname: Meco
mesh_terms: D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000139:chemically induced; D000818:Animals; D002415:Cats; D004785:Environmental Pollutants / Q000009:adverse effects*; D006801:Humans; D007855:Lead Poisoning / Q000209:etiology; D008297:Male; D008630:Mercury Poisoning / Q000209:etiology; D008670:Metals / Q000009:adverse effects*; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000139:chemically induced*; D009784:Occupational Diseases / Q000139:chemically induced*; D009790:Occupations; D011323:Primates; D051381:Rats; D012307:Risk Factors; D012997:Solvents / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D004785:Environmental Pollutants; D008670:Metals; D012997:Solvents