title: The effects of n-3 and n-6 polyunsaturated fatty acids on plasma lipids and fatty acids of treated phenylketonuric children.
abstract: Dietary-treated phenylketonuric patients (PKUs) display low levels of long-chain polyunsaturated fatty acids (PUFA) in plasma lipids. In a 6-month clinical trial we observed a decrease of triglycerides and an increase of n-3 long-chain PUFA in plasma of PKUs supplemented with fish oil, while no major differences in respect to the baseline values were found in a group supplemented with blackcurrant oil. A more complete source of long-chain PUFA of both the n-6 and n-3 series should be investigated for dietary supplementation of PKU patients.
authors.affiliation: Fifth Department of Pediatrics, University of Milan, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Agostoni
authors.forename: E
authors.initials: E
authors.lastname: Riva
authors.forename: G
authors.initials: G
authors.lastname: Biasucci
authors.forename: D
authors.initials: D
authors.lastname: Luotti
authors.forename: M G
authors.initials: MG
authors.lastname: Bruzzese
authors.forename: F
authors.initials: F
authors.lastname: Marangoni
authors.forename: M
authors.initials: M
authors.lastname: Giovannini
mesh_terms: D002648:Child; D002675:Child, Preschool; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D005227:Fatty Acids / Q000097:blood*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D010661:Phenylketonurias / Q000097:blood* / Q000178:diet therapy; D014280:Triglycerides / Q000097:blood
chemical_list: D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; D008055:Lipids; D014280:Triglycerides