Activities of monoamine oxidase-A and -B in adult rat cerebellum following neonatal X-irradiation.
The activities of monoamine oxidases, MAO-A and MAO-B, were separately determined in the cerebellum (CE) from adult rats neonatally exposed to 5 Gy X-irradiation. They were found to be markedly reduced: 58% and 66% of values from nonirradiated, littermate controls. Since the specific activities of both isoenzymes (per mg tissue weight) were not significantly different from controls, the reduction of activity per CE is basically explained by the irradiation-induced cerebellar atrophy. The unmodified MAO-A specific activity makes it highly improbable that the increase in the cerebellar noradrenaline content, characteristic of neonatally X-irradiated rats, could be due to a decreased neuronal metabolism of noradrenaline by this enzyme.
Guelman
L R
LR
1a Cátedra de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, Paraguay, Argentina.
Zieher
L M
LM
Zorrilla Zubilete
M A
MA
Dopico
A M
AM
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D002531:Cerebellum / Q000166:cytology / Q000201:enzymology* / Q000528:radiation effects*; D003010:Clorgyline / Q000494:pharmacology; D005260:Female; D007527:Isoenzymes / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism* / Q000528:radiation effects; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects; D051381:Rats; D017208:Rats, Wistar; D012642:Selegiline / Q000494:pharmacology
D007527:Isoenzymes; D008996:Monoamine Oxidase Inhibitors; D012642:Selegiline; D008995:Monoamine Oxidase; D003010:Clorgyline