The role of stromelysin-1 in stromal-epithelial interactions and cancer.
Stromelysin-1 was one of the first proteinases found to be associated with cancer. In this review we describe the role of stromelysin-1 in normal mammary gland involution. When stromelysin-1 is overexpressed in transgenic mice the mammary gland undergoes precocious involution and is predisposed to forming a reactive stroma resembling that of a wound site or a tumor. Stromelysin-1 may act as an oncogene because transgenic mice expressing an active form of the enzyme develop mammary tumors. These observations suggest that stromelysin-1 and other matrix metalloproteinases may be useful targets for therapeutic intervention in cancer.
Wiesen
J F
JF
Laboratory of Radiobiology and Environmental Health, University of California, San Francisco 94143-0750, USA.
Werb
Z
Z
D000818:Animals; D002450:Cell Communication; D004847:Epithelial Cells; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000201:enzymology*; D019278:Matrix Metalloproteinase 3 / Q000502:physiology*; D051379:Mice; D017154:Stromal Cells / Q000166:cytology / Q000201:enzymology*
D019278:Matrix Metalloproteinase 3