Behavioral effects of amylin injected intracerebroventricularly in the rat.
Amylin is a peptide of pancreatic origin that has been reported to possess high-affinity binding sites in the brain and to affect central dopaminergic and serotonergic neurotransmission. Administered ICV the peptide induced a dose-dependent decrease of locomotor activity without affecting grooming and sniffing. At a dose of 5 micrograms/ rat, it antagonized the hypermotility and stereotypies induced by s.c. injection of amphetamine (2 mg/kg) or of the dopamine receptor agonist, apomorphine (250 mg/kg). Amylin did not change significantly the effect of haloperidol (0.5 mg/kg, s.c.) on locomotor activity, grooming, and sniffing. Moreover, the peptide did not modify the locomotor behavior of animals injected with the 5-HT2 antagonist, ritanserin (2 mg/kg, s.c.). These results suggest that amylin may exert motor effects, probably by interfering with central dopaminergic neurotransmission.
Clementi
G
G
Institute of Pharmacology, University of Catania School Medicine, Italy.
Valerio
C
C
Emmi
I
I
Prato
A
A
Drago
F
F
D000661:Amphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000682:Amyloid / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D018491:Dopamine Agonists / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006120:Grooming; D006220:Haloperidol / Q000494:pharmacology; D007276:Injections, Intraventricular; D058228:Islet Amyloid Polypeptide; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016713:Ritanserin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology; D012919:Social Behavior; D013239:Stereotyped Behavior / Q000187:drug effects*
D000682:Amyloid; D018491:Dopamine Agonists; D058228:Islet Amyloid Polypeptide; D012702:Serotonin Antagonists; D016713:Ritanserin; D000661:Amphetamine; D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine