In vitro percutaneous absorption of piroxicam through synthetic membranes and abdominal rat skin.
The in vitro release of piroxicam from carbomer gels and its penetration through isopropyl myristate impregnated membranes and abdominal rat skin were investigated. Attempts were made to relate the differences in the release rate with physicochemical properties of the drug and the vehicle. The results showed that piroxicam is released from the topical gel formulations and diffuses through skin. It is suggested that although piroxicam flux across abdominal rat skin was lower than through isopropyl myristate membranes, this kind of membranes can be used in preliminary screening among the different piroxicam formulations.
Santoyo
S
S
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Navarra, Pamplona, Spain.
Arellano
A
A
Ygartua
P
P
Martín
C
C
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D066298:In Vitro Techniques; D008297:Male; D008567:Membranes, Artificial; D010894:Piroxicam / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D012869:Skin Absorption
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008567:Membranes, Artificial; D010894:Piroxicam