In-vitro evaluation of the antimicrobial activities of Enantia chlorantha Oliv. extractives.
A bioactivity-directed fractionation of the root-and stem-barks of Enantia chlorantha resulted in the isolation of palmatine chloride 1 and jatrorrhizine chloride 2 as the major antimicrobial constituents. MIC determinations indicated that these compounds were superior to those of well established broad spectrum antibiotics against some of the organisms used.
Moody
J O
JO
Chelsea Department of Pharmacy, King's College, University of London, United Kingdom.
Bloomfield
S F
SF
Hylands
P J
PJ
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001600:Berberine Alkaloids / Q000032:analysis; D001682:Biological Availability; D004353:Drug Evaluation, Preclinical; D006801:Humans; D016488:Medicine, African Traditional; D008826:Microbial Sensitivity Tests; D009549:Nigeria; D010946:Plants, Medicinal / Q000737:chemistry / Q000502:physiology*
D000890:Anti-Infective Agents; D001600:Berberine Alkaloids; C005413:palmatine