[The participation of the renin-angiotensin-aldosterone system in the pathogenesis of acute kidney failure in endotoxemia].
It was found in acute experiments on white rats that injection of Salmonella typhimurium lipopolysaccharide activates renin-angiotensin-aldosterone system (RAAS) and causes oligohydruria form of acute renal failure (ARF). Enalapril, angiotensin-converting enzyme, being injected simultaneously with endotoxin, increases diuresis, glomerular filtration rate, electrolytes excretion and reabsorption by proximal tubules, decreases proteinuria and blood nitrogen-down to the normal. Thus, RAAS takes part in endotoxemia ARF induction and enalapril has protective effect.
Krishtal'
N V
NV
Frolov
A F
AF
Kukharchuk
A L
AL
D058186:Acute Kidney Injury / Q000209:etiology* / Q000503:physiopathology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D004656:Enalapril / Q000627:therapeutic use; D004731:Endotoxins / Q000097:blood*; D008297:Male; D009846:Oliguria / Q000209:etiology / Q000503:physiopathology; D011239:Prednisolone / Q000627:therapeutic use; D051381:Rats; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology*; D012486:Salmonella typhimurium; D014115:Toxemia / Q000150:complications* / Q000503:physiopathology
D000806:Angiotensin-Converting Enzyme Inhibitors; D004731:Endotoxins; D004656:Enalapril; D011239:Prednisolone