title: Effect of new macrolide roxithromycin upon nasal polyps associated with chronic sinusitis.
abstract: We often observe shrinkage of nasal polyps with low-dose long-term macrolide treatment, which was recently developed in Japan for the treatment of intractable chronic sinusitis. In order to assess the efficacy of this treatment for nasal polyps, we administered the new macrolide roxithromycin (RXM) (1 tablet: 150 mg a day) for at least 8 weeks to 20 patients with nasal polyps associated with chronic sinusitis. It was competent in controlling nasal polyp with the overall incidence of improvement being 52%. The combination of RXM with azelastine (1 mg twice/day), an inhibitor of mediator release, was examined in 20 other patients. It augmented the rate of improvement to 68%, but the increase was not significant. The incidence of improvement increased with time after the start of medication in both groups. Smaller polyps were more likely to decrease in size, but some larger polyps also markedly decreased in size. Associated allergic conditions and the extent of eosinophilic infiltration had no relation to the treatment result. We speculate that the mechanism of effectiveness of RXM is through its suppressive potency in cytokine production from inflammatory cells.
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ichimura
authors.forename: Y
authors.initials: Y
authors.lastname: Shimazaki
authors.forename: T
authors.initials: T
authors.lastname: Ishibashi
authors.forename: R
authors.initials: R
authors.lastname: Higo
mesh_terms: D000328:Adult; D016207:Cytokines / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D018942:Macrolides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000188:drug therapy* / Q000209:etiology*; D010793:Phthalazines / Q000008:administration & dosage / Q000627:therapeutic use*; D015575:Roxithromycin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D012852:Sinusitis / Q000150:complications*
chemical_list: D016207:Cytokines; D006634:Histamine H1 Antagonists; D018942:Macrolides; D010793:Phthalazines; D015575:Roxithromycin; C020976:azelastine