Effect of furosemide oral solution versus furosemide tablets on diuresis and electrolytes in patients with moderate congestive heart failure.
Oral furosemide solution was claimed to produce a greater diuretic response than furosemide tablets in patients with congestive heart failure. The aim of this study was to assess this observation and to further investigate the effects on the electrolyte balance. We compared the effects of oral furosemide in tablets versus oral furosemide solution on serum levels as well as on 4- and cumulative 24-hour urinary volume and sodium, potassium, calcium, magnesium and zinc excretions in 10 patients with moderate congestive heart failure due to ischemic heart disease. Oral furosemide (40-80 mg) was given at the usual once-daily dosage. No change in serum electrolyte levels has been found. All urinary parameters, except zinc, were significantly greater during the first 4 h following oral solution as compared with tablets (volume p < 0.001, sodium p < 0.001, potassium p < 0.05, calcium p < 0.003, magnesium p < 0.05). However, after 24 h, significant differences were found in urinary volume (p < 0.03) and sodium excretion (p < 0.004) only. We conclude that: (1) oral furosemide solution provides a more potent 24-hour diuretic and natriuretic effect than an identical dosage in tablet form, without entailing greater cumulative urinary losses of potassium, calcium, magnesium, and zinc; (2) following the first 4 h of furosemide solution, brisk diuresis, kaliuresis, and magnesiuria are produced, and (3) despite the urinary losses, serum electrolytes remained within normal limits at 4 and 24 h.
Cohen
N
N
Department of Internal Medicine A, Assaf Harofeh Medical Center, Zerifin, Israel.
Golik
A
A
Dishi
V
V
Zaidenstein
R
R
Weissgarten
J
J
Averbukh
Z
Z
Modai
D
D
D000368:Aged; D000369:Aged, 80 and over; D002118:Calcium / Q000097:blood / Q000652:urine; D004231:Diuresis / Q000187:drug effects*; D004573:Electrolytes / Q000097:blood* / Q000652:urine*; D005260:Female; D005665:Furosemide / Q000008:administration & dosage* / Q000627:therapeutic use; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008274:Magnesium / Q000097:blood / Q000652:urine; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood / Q000652:urine; D012996:Solutions; D013607:Tablets; D015032:Zinc / Q000097:blood / Q000652:urine
D004573:Electrolytes; D012996:Solutions; D013607:Tablets; D005665:Furosemide; D008274:Magnesium; D015032:Zinc; D011188:Potassium; D002118:Calcium