title: Noninvasive perfusion imaging of human brain tumors with EPISTAR.
abstract: A total of 17 patients with histologically proven diagnoses of low-grade astrocytoma (n = 4), high-grade astrocytoma (n = 8), lymphoma (n = 3), and meningioma (n = 2) were examined by using EPISTAR MR imaging. Meningiomas had the highest EPISTAR tumor/white matter contrast and low-grade astrocytomas and lymphomas the lowest. High-grade astrocytomas demonstrated elevated EPISTAR signal with marked regional heterogeneity. There was agreement between tumor vascularity by SPECT and EPISTAR in the five cases where both were done. Our results show that tumor vascularity can be assessed qualitatively by using EPISTAR without the need for contrast medium injection.
authors.affiliation: Department of Radiology, Beth Israel Hospital, Boston, MA 02215, USA.
authors.forename: J
authors.initials: J
authors.lastname: Gaa
authors.forename: S
authors.initials: S
authors.lastname: Warach
authors.forename: P
authors.initials: P
authors.lastname: Wen
authors.forename: V
authors.initials: V
authors.lastname: Thangaraj
authors.forename: P
authors.initials: P
authors.lastname: Wielopolski
authors.forename: R R
authors.initials: RR
authors.lastname: Edelman
mesh_terms: D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000098:blood supply / Q000175:diagnosis / Q000000981:diagnostic imaging; D001932:Brain Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D003287:Contrast Media; D017352:Echo-Planar Imaging; D005260:Female; D005909:Glioblastoma / Q000098:blood supply / Q000175:diagnosis / Q000000981:diagnostic imaging; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008223:Lymphoma / Q000175:diagnosis / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008577:Meningeal Neoplasms / Q000098:blood supply / Q000175:diagnosis / Q000000981:diagnostic imaging; D008579:Meningioma / Q000098:blood supply / Q000175:diagnosis / Q000000981:diagnostic imaging; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D003287:Contrast Media; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime