title: Histopathological changes in the reproductive organs of Manchego ewes grazing on lucerne.
abstract: The effects of prolonged exposure to phyto-oestrogens (coumestrol) on the morphology of the reproductive organs of ewes were studied in 28 lucerne-grazing animals, and compared with 28 control ewes given a standard coumestrol-free diet. The anatomical studies showed that 43% of the ewes fed lucerne displayed macroscopic changes within the genital tract, of which the uterine alterations were especially prominent. The microscopic examination of the test group ewes identified specific histopathological features of the uterus and cervix. A greater than normal development of the cervical folds was observed, as well as cystic formations of different sizes whose content was eosinophilic. In the rest of the uterus, more glandular activity was detected in the lucerne-grazing group than in the control ewes, although cystic formations were not seen.
authors.affiliation: State Agrarian Investigation Service of the Community of Madrid, El Encin Farm, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Cantero
authors.forename: J L
authors.initials: JL
authors.lastname: Sancha
authors.forename: J M
authors.initials: JM
authors.lastname: Flores
authors.forename: A
authors.initials: A
authors.lastname: Rodriguez
authors.forename: T
authors.initials: T
authors.lastname: Gonzalez
mesh_terms: D000818:Animals; D002584:Cervix Uteri / Q000473:pathology*; D003375:Coumestrol / Q000009:adverse effects*; D005260:Female; D000455:Medicago sativa / Q000009:adverse effects*; D011897:Random Allocation; D012756:Sheep / Q000033:anatomy & histology* / Q000502:physiology; D014599:Uterus / Q000473:pathology* / Q000502:physiology
chemical_list: D003375:Coumestrol