title: Effect of spironolactone on antipyrine metabolism in calves.
abstract: Ten female calves of the Black and White breed aged seven to eight days were studied before and after seven days of treatment with spironolactone at a dose rate of 1 mg kg bodyweight-1 twice a day. The treatment was associated with a statistically significant decrease in the half-life of antipyrine in plasma and an increase in its rate of metabolic clearance. The excretion of 4-hydroxyantipyrine in urine was significantly increased after the treatment with spironolactone, but there were no changes in the rates of excretion of 3-hydroxymethylantipyrine or norantipyrine. These results indicate that spironolactone enhanced the activity of the microsomal drug-metabolising enzyme system and induced cytochrome P-450 in the calves.
authors.affiliation: Department of Animal Physiology, University of Agriculture, Szczecin, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Janus
authors.forename: J
authors.initials: J
authors.lastname: Suszycka
mesh_terms: D000818:Animals; D000983:Antipyrine / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics; D001711:Biotransformation; D002417:Cattle; D005260:Female; D006207:Half-Life; D008657:Metabolic Clearance Rate; D013148:Spironolactone / Q000494:pharmacology*
chemical_list: D013148:Spironolactone; D000983:Antipyrine