Nuclear hormone receptors: ligand-activated regulators of transcription and diverse cell responses.
Signal transduction via nuclear hormone receptors is unusual in that the hormone ligand forms an integral part of the protein complex involved in DNA binding and transcriptional activation. New structural and biochemical results have begun to unravel how these receptors produce different effects in different cells, and the structural changes involved in transcriptional activation.
Katzenellenbogen
J A
JA
Department of Chemistry, University of Illinois, Urbana, IL 61801, USA.
Katzenellenbogen
B S
BS
D000818:Animals; D004247:DNA / Q000378:metabolism; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D011487:Protein Conformation; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry / Q000378:metabolism*; D015533:Transcriptional Activation
D008024:Ligands; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D004247:DNA