Inhibition of food intake in rats by the K+ channel opener cromakalim.
We studied the effect of the K+ channel opener cromakalim, which exhibits antihypertensive properties, on food intake in rats. Intraperitoneally injected cromakalim induced a dose-dependent (0.1, 0.5, and 1.0 mg/kg body wt.) reduction in food intake, which was associated with an inhibition of gastric emptying. The anorectic effect was not influenced by subdiaphragmatic vagotomy. Cromakalim's anorectic effect did not appear to be due to a learned taste aversion. Therefore, an intact abdominal vagus is not a prerequisite for cromakalim's anorectic effect.
Del Prete
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Institut für Veterinär-Physiologie, Universität Zürich, Switzerland.
Lutz
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TA
Scharrer
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D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D019806:Cromakalim; D003864:Depression, Chemical; D004032:Diet; D004435:Eating / Q000187:drug effects*; D005746:Gastric Emptying / Q000187:drug effects; D008297:Male; D015221:Potassium Channels / Q000187:drug effects / Q000378:metabolism*; D011758:Pyrroles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013649:Taste / Q000187:drug effects; D014628:Vagotomy
D001578:Benzopyrans; D015221:Potassium Channels; D011758:Pyrroles; D019806:Cromakalim