The epilepsy of trisomy 9p.
Trisomy 9p is associated with structural abnormalities of the brain, neurologic dysfunction, and epilepsy. This report of a 27-year-old man with trisomy 9p and complex partial epilepsy is the first with a detailed description of the epilepsy associated with trisomy 9p. The patient's EEG shows multifocal independent spike discharges and an asymmetric generalized spike discharge. In the first MRI obtained on an adult with this disorder, we find poorly developed white matter, an atrophic corpus callosum and cerebellum, and a choroidal fissure cyst.
Stern
J M
JM
Department of Neurology, UCLA School of Medicine 90095-1769, USA.
D000328:Adult; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D004569:Electroencephalography; D004827:Epilepsy / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D014314:Trisomy / Q000235:genetics*