T-cell recognition of non-peptide antigens.
Studies of two distinct human T-cell systems have provided the exciting finding that T cells are able to recognize non-peptide antigens: gammadelta T cells have been shown to recognize isopentenyl pyrophosphate and related structures and human CD1 has been shown to present microbial lipids and lipoglycans such as mycolic acids and lipoarabinomannan to T cells. T-cell responses to these non-peptide antigens should provide a strategic target for immunologic intervention in infectious disease.
Porcelli
S A
SA
Division of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Morita
C T
CT
Modlin
R L
RL
D017951:Antigen Presentation; D000942:Antigens, Bacterial / Q000737:chemistry* / Q000276:immunology*; D002240:Carbohydrate Sequence; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology*; D008969:Molecular Sequence Data; D013601:T-Lymphocytes / Q000276:immunology*
D000942:Antigens, Bacterial; D008070:Lipopolysaccharides