Cooperative interaction between Cra and Fnr in the regulation of the cydAB operon of Escherichia coli.
In vivo and in vitro experiments are reported demonstrating that the catabolite repressor-activator (Cra) protein (formerly designated FruR) regulates expression of the cydAB operon of Escherichia coli encoding cytochrome d oxidase. The Fnr protein is required for Cra-mediated transcriptional control, but the ArcA protein antagonizes the response to Cra. The results establish that Fnr, ArcA, and Cra exert their effects in an interdependent fashion.
Ramseier
T M
TM
Department of Biology, University of California at San Diego, La Jolla, CA 92093-0116, USA.
Chien
S Y
SY
Saier
M H
MH
D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000235:genetics*; D002874:Chromosome Mapping; D004269:DNA, Bacterial / Q000032:analysis; D003576:Electron Transport Complex IV / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics*; D029968:Escherichia coli Proteins; D005696:Galactosidases / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D007506:Iron-Sulfur Proteins / Q000235:genetics*; D009876:Operon / Q000502:physiology*; D012097:Repressor Proteins / Q000037:antagonists & inhibitors / Q000235:genetics*; D014158:Transcription, Genetic; D056968:Lac Repressors
D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D003576:Electron Transport Complex IV; D029968:Escherichia coli Proteins; D005696:Galactosidases; D007506:Iron-Sulfur Proteins; D012097:Repressor Proteins; C060704:FNR protein, E coli; C489416:FruR protein, E coli; C041610:arcA protein, E coli; C068837:FruR protein, Bacteria; D056968:Lac Repressors