A neural substrate of hyperactivity in borna disease: changes in brain dopamine receptors.
Rats experimentally infected with the neurotropic RNA virus, Borna disease virus, have a hyperactive movement disorder. Because locomotor activity is modulated by the nucleus accumbens (N. Acc.) dopamine (DA) system, high-affinity DA uptake, DA D1, D2, and D3 receptor binding sites were examined in N. Acc. subregions of normal and infected rats by quantitative receptor autoradiography. The N. Acc. of infected rats had decreased mazindol and D2 and D3 radioligand binding in the core and decreased D3 radioligand binding in rostral subregions. The abnormalities observed in the N. Acc. DA system of infected rats may offer insights into the potential viral pathogenesis of psychiatric conditions with a dopaminergic substrate such as schizophrenia and affective disorders.
Solbrig
M V
MV
Department of Neurology, Markey Program in Human Neurobiology, University of California at Irvine 92717, USA.
Koob
G F
GF
Joyce
J N
JN
Lipkin
W I
WI
D000818:Animals; D001345:Autoradiography; D001890:Borna Disease / Q000378:metabolism* / Q000503:physiopathology / Q000821:virology; D001891:Borna disease virus; D006948:Hyperkinesis / Q000209:etiology / Q000378:metabolism; D017403:In Situ Hybridization; D008297:Male; D009714:Nucleus Accumbens / Q000378:metabolism* / Q000821:virology; D012367:RNA, Viral / Q000032:analysis; D051381:Rats; D011917:Rats, Inbred Lew; D011954:Receptors, Dopamine / Q000378:metabolism*; D017447:Receptors, Dopamine D1 / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D050637:Receptors, Dopamine D3
C493595:Drd3 protein, rat; D012367:RNA, Viral; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3