An Epstein Barr virus-related cross reactive autoimmune response in multiple sclerosis in Norway.
In studies of patients in Norway with multiple sclerosis (MS), we have found cross reactive autoantibodies related to the Epstein Barr virus nuclear antigen-1 (EBNA-1). The MS patients had elevated IgG antibody to EBNA-1, as measured by reactivity with a synthetic glycine/alanine peptide, P62, which represents the glycine/alanine repeat in EBNA-1. The mean titer of anti-P62 in patients with acute relapse at the time of assay was significantly higher than in the remaining patients. Patients with remitting/relapsing MS also had elevated autoantibody to a lymphocyte protein, p542, cross reactive with EBNA-1 through a glycine/serine epitope. High titered anti-EBNA-1 antibodies from some MS, as well as from some SLE sera, were shown to cross react with 80-82 kDa and 60 kDa proteins in neuroglial cells.
Vaughan
J H
JH
Department of Medicine-0663, University of California, San Diego, La Jolla 92093, USA. jvaughan@ucsd.edu
Riise
T
T
Rhodes
G H
GH
Nguyen
M D
MD
Barrett-Connor
E
E
Nyland
H
H
D000595:Amino Acid Sequence; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000737:chemistry / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D003429:Cross Reactions; D019309:Epstein-Barr Virus Nuclear Antigens / Q000276:immunology*; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D009103:Multiple Sclerosis / Q000276:immunology*; D009664:Norway; D010455:Peptides / Q000276:immunology
D001323:Autoantibodies; D001324:Autoantigens; D019309:Epstein-Barr Virus Nuclear Antigens; D010455:Peptides