title: Impact of antenatal diagnosis on incidence and prognosis in abdominal wall defects.
abstract: The authors review data from the Congenital Malformation Registry in South East Thames regarding fetal abdominal wall defects. Over 24 months, 80 cases were observed (40 gastroschisis, 40 exomphalos). Live-born infants with gastroschisis had few associated anomalies and an excellent prognosis (83% survival rate). Exomphalos is associated with an increased rate of life-threatening anomalies and chromosomal defects. The latter cases often are terminated prenatally. If these cases are excluded, the 1-year survival rate for liveborn infants with exomphalos is favorable (close to 80%). Fetuses in whom gastroschisis and exomphalos are identified by ultrasonography but who have no associated life-threatening chromosomal anomalies should have a favorable prognosis.
authors.affiliation: South East Thames Congenital Malformation Registry, Children's Hospital, London, England.
authors.forename: R
authors.initials: R
authors.lastname: Fisher
authors.forename: A
authors.initials: A
authors.lastname: Attah
authors.forename: A
authors.initials: A
authors.lastname: Partington
authors.forename: E
authors.initials: E
authors.lastname: Dykes
mesh_terms: D000009:Abdominal Muscles / Q000002:abnormalities*; D000015:Abnormalities, Multiple / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000517:prevention & control*; D003430:Cross-Sectional Studies; D004739:England / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006554:Hernia, Umbilical / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis; D016216:Ultrasonography, Prenatal