title: 3D MR angiography with ramp-shaped flip-angle distribution.
abstract: This study addressed the use of 3D MR angiography with flip angles (FAs) linearly varying across the excitation volume in order to diminish spin saturation. The shape of the ramp profile was varied to optimize the method for different regions and pathological alterations. Radio frequency pulses with ramp-shaped excitation profiles were generated using Fourier transformation and integrated into a flow-compensated 3D-FISP sequence. With the use of ramp-shaped excitation profiles good results were obtained for intracranial arteries as well as for neck arteries (i.e. carotid and vertebral arteries) which were demonstrated in 6 healthy volunteers and in 5 patients with various stenoses and anomalies of the carotid and vertebral arteries. With this technique it was possible to use increased thicknesses of the excitation volume (slab) up to 256 mm. Ramp-shaped excitation pulses with linearly increasing FAs in main flow direction can provide improved contrast of the vessel parts located distally to the entry side of the slab. Although this method has no advantage concerning complex flow or other dephasing effects; its particular effectiveness lies in the reduction of spin saturation.
authors.affiliation: National Institute of Neurosurgery, Budapest, Hungary.
authors.forename: J
authors.initials: J
authors.lastname: Martos
authors.forename: T
authors.initials: T
authors.lastname: Nägele
authors.forename: U
authors.initials: U
authors.lastname: Klose
authors.forename: D
authors.initials: D
authors.lastname: Petersen
authors.forename: K
authors.initials: K
authors.lastname: Voigt
mesh_terms: D000368:Aged; D001157:Arterial Occlusive Diseases / Q000175:diagnosis; D001921:Brain / Q000098:blood supply; D002339:Carotid Arteries / Q000473:pathology; D017536:Carotid Artery, Common / Q000473:pathology; D002342:Carotid Artery, External / Q000473:pathology; D002343:Carotid Artery, Internal / Q000473:pathology; D016893:Carotid Stenosis / Q000175:diagnosis; D003251:Constriction, Pathologic / Q000175:diagnosis; D005583:Fourier Analysis; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow; D014711:Vertebral Artery / Q000473:pathology