Corticosteroid contact hypersensitivity: what vehicle and concentration?
The correct concentration and vehicle for patch testing with corticosteroids is in many instances not known. The results of this study suggest that 1% in ethanol should be the initial choice, unless it can be shown that petrolatum as a vehicle is as sensitive (tixocortol pivalate and budesonide). We could find no evidence for the anti-inflammatory effects of corticosteroids inhibiting the patch test at higher concentrations. Using ethanol as the vehicle resulted in reactions developing at earlier time points than with petrolatum.
Wilkinson
S M
SM
Skin Hospital, Manchester, UK.
Beck
M H
MH
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D019819:Budesonide; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000209:etiology; D003879:Dermatologic Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology; D000431:Ethanol; D006801:Humans; D006854:Hydrocortisone / Q000009:adverse effects / Q000031:analogs & derivatives*; D010328:Patch Tests / Q000379:methods*; D010577:Petrolatum; D014677:Pharmaceutical Vehicles; D011282:Pregnenediones / Q000009:adverse effects*
D000893:Anti-Inflammatory Agents; D003879:Dermatologic Agents; D014677:Pharmaceutical Vehicles; D011282:Pregnenediones; C007975:hydrocortisone-17-butyrate; D000431:Ethanol; D019819:Budesonide; C019112:tixocortol pivalate; D010577:Petrolatum; D006854:Hydrocortisone