Recovery of olfactory function in thirteen-day-old rats after olfactory bulb transplantation but not after olfactory bulb ablation.
Previous studies have shown recovery of olfactory ability along with reconnectivity of olfactory nerve (ON) following both olfactory bulb (OB) lesions and OB transplants (TX) when performed in newborn rats. The purpose of the present study is to correlate functional recovery with patterns of anatomical reconnectivity in older, postnatal (PN) 13-day-old rats (a possible critical period for plasticity in the system). Reinnervation of olfactory areas was seen in all OB TX animals regardless of the extent of functional recovery. Eight of nineteen animals with OB TXs demonstrated some degree of behavioral recovery. No reinnervation or behavioral recovery of OB lesion animals was observed. At this age, behavioral recovery is dependent upon reconnectivity within the system and transplantation may be required to facilitate this process.
Evers
S M
SM
Department of Neurological Surgery, University of Washington, Seattle 98195, USA.
Hendricks
K R
KR
Kott
J N
JN
Lee
M E
ME
Gregov
M E
ME
Westrum
L E
LE
D000367:Age Factors; D000758:Anesthesia; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D015415:Biomarkers / Q000032:analysis; D003213:Conditioning, Psychological / Q000502:physiology; D005260:Female; D005508:Food Deprivation; D008297:Male; D009419:Nerve Tissue Proteins / Q000032:analysis; D009473:Neuronal Plasticity / Q000502:physiology; D009830:Olfactory Bulb / Q000737:chemistry / Q000601:surgery* / Q000637:transplantation*; D051842:Olfactory Marker Protein; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012903:Smell / Q000502:physiology*
D015415:Biomarkers; D009419:Nerve Tissue Proteins; D051842:Olfactory Marker Protein; C497599:Omp protein, rat