Studies on the formation of hepatic DNA adducts by the antiandrogenic and gestagenic drug, cyproterone acetate: 1. adduct levels in various species including man and 2. persistence and accumulation in the rat.
Werner
S
S
GSF-Forschungszentrum für Umwelt und Gesundheit, Institut für Toxikologie, Oberschleissheim, Germany.
Topinka
J
J
Kunz
S
S
Beckurts
T
T
Heidecke
C D
CD
Schwarz
L R
LR
Wolff
T
T
D000726:Androgen Antagonists / Q000378:metabolism* / Q000633:toxicity*; D000818:Animals; D002478:Cells, Cultured; D017373:Cyproterone Acetate / Q000378:metabolism* / Q000633:toxicity*; D018736:DNA Adducts / Q000378:metabolism*; D016172:DNA Fingerprinting; D005260:Female; D006727:Hormone Antagonists / Q000378:metabolism* / Q000633:toxicity*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013552:Swine
D000726:Androgen Antagonists; D018736:DNA Adducts; D006727:Hormone Antagonists; D017373:Cyproterone Acetate