title: Diagnostic value of nasal provocation testing and rhinomanometry in allergic rhinitis.
abstract: We studied 32 patients, aged 7 to 17 years, with clinical symptoms of perennial allergic rhinitis, isolated (n = 21) or associated with asthma (n = 11), all of them with positive skin test and specific serum IgE for Dermatophagoides pteronyssinus (Dpt). The control group consisted of 10 children aged 7 to 16 years, with no personal or family history of allergy and with negative skin tests and negative specific serum IgE for mites. Total and specific IgE measurements in nasal secretion and nasal provocation testing (NPT) were also performed with increasing concentrations of Dermatophagoides pteronyssinus (Dpt) extracts. The nasal response was evaluated using a clinical score and active anterior rhinomanometry. The levels of total and specific IgE in nasal secretion were higher in patients with allergic rhinitis than in individuals from the control group. The NPT presented a significant correlation with clinical symptoms, skin tests and specific serum IgE. None of the individuals from the control group presented a positive NPT. No generalized reactions or bronchial response at the immediate phase of NPT were observed. The NPT constitutes a safe, dependable investigative procedure of nasal reactivity to a specific allergen, presenting a good sensitivity and specificity when compared to the other methods classically used in allergy studies.
authors.affiliation: Universidade Federal de São Pãulo, Brazil.
authors.forename: F R
authors.initials: FR
authors.lastname: Fernandes
authors.forename: D
authors.initials: D
authors.lastname: Solé
authors.forename: C
authors.initials: C
authors.lastname: Naspitz
authors.forename: F
authors.initials: F
authors.lastname: Muñoz-López
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000276:immunology; D039741:Antigens, Dermatophagoides; D002648:Child; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008365:Manometry; D009297:Nasal Mucosa / Q000276:immunology / Q000378:metabolism; D009299:Nasal Provocation Tests / Q000706:statistics & numerical data; D011237:Predictive Value of Tests; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis*
chemical_list: D000485:Allergens; D039741:Antigens, Dermatophagoides; D006023:Glycoproteins; D007073:Immunoglobulin E