Long term follow-up of children with mixed connective tissue disease.
Mixed connective tissue disease (MCTD) is characterized by features of more than one of the rheumatic disorders with antinuclear antibodies in a speckled pattern and with antibodies to nuclear ribonucleoprotein (nRNP). MCTD is uncommon in children and long-term follow-up studies in children are infrequently reported. A retrospective review of clinical experience at five pediatric rheumatology centers provided 11 patients who met the following inclusion criteria: (1) Kasukawa's criteria for MCTD1; (2) presentation younger than 18th birthday; (3) greater than five years of follow-up; (4) completion of data collection form. The widely varying outcomes of these 11 children with MCTD on long-term follow-up may lend doubt that this is a unique and distinctive rheumatologic disorder.
Mier
R
R
Shriners Hospital, Lexington, Kentucky 40502, USA.
Ansell
B
B
Hall
M A
MA
Hasson
N
N
Levinson
J
J
Lovell
D
D
Passo
M
M
Rennebohm
R
R
Woo
P
P
D000293:Adolescent; D000974:Antibodies, Antinuclear / Q000097:blood; D001324:Autoantigens; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006680:HLA Antigens; D006801:Humans; D008297:Male; D008947:Mixed Connective Tissue Disease / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D011379:Prognosis; D012189:Retrospective Studies; D012261:Ribonucleoproteins / Q000276:immunology; D055517:snRNP Core Proteins
D000974:Antibodies, Antinuclear; D001324:Autoantigens; D006680:HLA Antigens; D012261:Ribonucleoproteins; D055517:snRNP Core Proteins