title: Serum insulin-like growth factor-I (IGF-I) in normal Japanese adults.
abstract: To evaluate surgical and medical treatment of GH-producing pituitary tumors and GH supplement to GH-deficient patients, we determined the reference values for serum IGF-I in Japanese adults. The serum IGF-I concentration in 454 apparently healthy subjects (246 men aged 21-70 years and 208 women aged 21-72 years) was measured with a commercial RIA kit after acid-ethanol extraction. The concentration of serum IGF-I decreased with age in both sexes. The IGF-I in females was significantly higher than that in males in the group aged 21-30 years and lower in the group aged 61-72 years. We conclude that an age- or sex-related standard is necessary for comparing IGF-I values in patients.
authors.affiliation: Clinical Endocrine Laboratory, Toranomon Hospital, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kitano
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: Y
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Umezu
authors.forename: Y
authors.initials: Y
authors.lastname: Arakawa
authors.forename: Y
authors.initials: Y
authors.lastname: Daimon
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007564:Japan; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D017678:Sex Distribution
chemical_list: D007334:Insulin-Like Growth Factor I