title: Oligonucleotide directed triple helix formation.
abstract: Oligonucleotide directed triple helix formation allows the sequence-specific recognition of the major groove of double-helical DNA. Recently synthesized base analogs and backbones, such as N3'-->P5' phosphoramidates, allow stable triplexes to be formed under physiological conditions. However, it remains a challenge to design new oligomers that would extend the range of recognition sequences (which are still limited to oligopurine-rich tracts). Oligonucleotide directed triple helix formation could be used to control biological processes such as transcription and replication. Three-stranded structures formed during recombination processes have been further characterized.
authors.affiliation: Laboratoire de Biophysique, Muséum National d'Histoire Naturelle, INSERM U201, Centre National de la Recherche Scientifique, URA481, Paris, France. biophy@mnhn.fr
authors.forename: J S
authors.initials: JS
authors.lastname: Sun
authors.forename: T
authors.initials: T
authors.lastname: Garestier
authors.forename: C
authors.initials: C
authors.lastname: Hélène
mesh_terms: D001482:Base Composition; D004247:DNA / Q000737:chemistry; D007700:Kinetics; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry; D011938:Rec A Recombinases / Q000737:chemistry / Q000235:genetics; D013816:Thermodynamics
chemical_list: C051802:triplex DNA; D012313:RNA; D004247:DNA; D011938:Rec A Recombinases