Turning off natural killers. Innate immunity.
Inhibitory receptors specific for class I molecules of the major histocompatibility complex regulate the cytolytic activity of natural killer cells. Recent studies suggest that recruitment of the protein tyrosine phosphatase SHP-1 enables these receptors to block natural killing.
Imboden
J
J
Department of Medicine, San Francisco General Hospital and the University of California, Box 0868, San Francisco, 94143, USA.
D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D011971:Receptors, Immunologic / Q000276:immunology; D013379:Substrate Specificity
D015395:Histocompatibility Antigens Class I; D047908:Intracellular Signaling Peptides and Proteins; D011971:Receptors, Immunologic; C516724:PTPN11 protein, human; C509249:PTPN6 protein, human; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases