Effect of angiotensin-converting enzyme genotype on renin-angiotensin components in hypertensives.
Plasma angiotensin-converting enzyme (ACE) tracks with the deletion allele of an insertion/deletion (I/D) polymorphism of the ACE gene. The aim of the present study was to determine plasma renin and angiotensinogen for each ACE genotype in 54 hypertensive and 96 normotensive subjects. Plasma renin was reduced by 52 +/- 15 S.E.% in DD and by 24 +/- 12% in ID hypertensives when compared to II hypertensives (P < 0.05 by one-way ANOVA), but in the normotensive subjects, renin values were similar for each genotype. Plasma angiotensinogen did not differ across ACE genotypes, but was elevated by 25 +/- 3 S.E.% in hypertensives and showed a significant correlation with blood pressure. In conclusion, although renin does not differ significantly between ACE genotypes of normotensives, a reciprocal relationship may exist between plasma renin and plasma ACE in hypertensives.
Zee
R Y
RY
Department of Physiology, University of Sydney, New South Wales, Australia.
Schrader
A P
AP
Morris
B J
BJ
D000328:Adult; D000808:Angiotensinogen / Q000097:blood; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000235:genetics*
D000808:Angiotensinogen; D007703:Peptidyl-Dipeptidase A; D012083:Renin