title: Identification of a neuronal cell surface molecule, plexin, in mice.
abstract: We searched for mouse homologues of the cell adhesion protein plexin which was originally found in Xenopus, and obtained a cDNA encoding a plexin-like protein. We referred to this protein as mouse plexin 1. The overall amino acid identity between mouse plexin 1 and Xenopus plexin was 84%. As in the Xenopus plexin, the extracellular segment of mouse plexin 1 protein possessed three cysteine-rich domains which showed significant homology with the cysteine-rich domain of the c-Met proto-oncogene protein product (c-Met protein) and Met-like receptor protein tyrosine kinases. Northern blot analysis indicated that mouse plexin 1 was predominantly expressed in the brain.
authors.affiliation: Laboratory of Development Biology, Nagoya University Graduate School of Science, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kameyama
authors.forename: Y
authors.initials: Y
authors.lastname: Murakami
authors.forename: F
authors.initials: F
authors.lastname: Suto
authors.forename: A
authors.initials: A
authors.lastname: Kawakami
authors.forename: S
authors.initials: S
authors.lastname: Takagi
authors.forename: T
authors.initials: T
authors.lastname: Hirata
authors.forename: H
authors.initials: H
authors.lastname: Fujisawa
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D003001:Cloning, Molecular; D018076:DNA, Complementary; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D012313:RNA / Q000235:genetics / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
chemical_list: D015815:Cell Adhesion Molecules; D018076:DNA, Complementary; D009419:Nerve Tissue Proteins; C091529:plexin; D012313:RNA