title: Severe acute graft-versus-host disease of conjunctivae after allogeneic blood progenitor cell infusion.
abstract: A 37-year-old woman with Philadelphia chromosome-positive acute lymphoblastic leukemia received allogeneic bone marrow transplants after first and second relapses from different HLA-identical brothers. After a third relapse, blood progenitor cells from one of the brothers were infused after six doses of cytarabine 1.5 g/m2 in an attempt to induce a graft-versus-leukemia effect. Seven weeks after the infusion, the patient developed delayed but severe acute graft-versus-host disease (GVHD) including the unusual manifestation of conjunctival involvement.
authors.affiliation: Department of Medicine, Ireland Cancer Center; Cleveland, OH, USA.
authors.forename: T P
authors.initials: TP
authors.lastname: Spiro
authors.forename: D G
authors.initials: DG
authors.lastname: O'Day
authors.forename: D
authors.initials: D
authors.lastname: Bardenstein
authors.forename: B W
authors.initials: BW
authors.lastname: Cooper
authors.forename: H M
authors.initials: HM
authors.lastname: Lazarus
mesh_terms: D000208:Acute Disease; D000328:Adult; D003229:Conjunctival Diseases / Q000209:etiology*; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D014184:Transplantation, Homologous