title: Simulation of mechanical respiration using a multicompartment model for ventilation mechanics and gas exchange.
abstract: The mechanical respiration of intubated patients is a process which is influenced by many parameters and, through its many interactions, is extremely complex. Taken by itself the logical analysis of this complexity is extraordinarily difficult and leads very often to false conclusions. For that reason computer simulation of complex systems by means of the computer is an important tool in the analysis of these processes. Required is a model which describes the actual behavior of the system. However, it should not be overlooked that a model always describes only a portion of reality. Models having exclusively to do with ventilation mechanics or with gas exchange cannot simulate the interactions between the two. To accomplish this purpose, an improved model is necessary, including both partial processes and thereby capturing the complexity of the system. Accordingly, both ventilation mechanics and gas exchange have been integrated equally into the newly developed model for the simulation program Simu Vent. The core of the program builds a functional multicompartment model of the lungs and considers the partial processes ventilation mechanics, gas transport, gas mixing and gas exchange. Further considered are the respirator, blood circulation and peripheral compartments. The program runs under a graphical user interface, allowing its easy use. Responsible for this ease is the user's ability to interact with the program while simulation is in progress and the specially designed graphic screen mask. Comparing measured with simulated values demonstrated that the measured curve can be simulated with minimal error. Furthermore, the multicompartment model describes disruptions in distribution. Simu Vent's application is especially well advised in the description and analysis of the theoretical fundamentals of mechanical respiration. This aspect is meaningful above all in education and research, rendering these two the model's main areas of use.
authors.affiliation: Technische Universität Dresden, Institute of Biomedical Engineering, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Winkler
authors.forename: A
authors.initials: A
authors.lastname: Krause
authors.forename: S
authors.initials: S
authors.lastname: Kaiser
mesh_terms: D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D011659:Pulmonary Gas Exchange; D012121:Respiration, Artificial / Q000706:statistics & numerical data; D015656:Respiratory Mechanics; D012984:Software; D014584:User-Computer Interface; D012122:Ventilators, Mechanical / Q000706:statistics & numerical data