title: Fluconazole in Candida albicans sepsis during pregnancy: case report and review of the literature.
abstract: Candida sepsis during pregnancy is a rare but life-threatening complication of infection with Candida albicans. In contrast to the situation with other antimicrobial agents, there exists only limited experience with systemic antifungal therapy during pregnancy. A recent report focuses on amphotericin B treatment in systemic fungal infection during pregnancy. The present report discusses a pregnant patient with Candida albicans sepsis and endophthalmitis as well as candida infection of the oral and genital mucous membranes, after hyperalimentation and broad spectrum antibiotic therapy via a central venous catheter. The patient was treated with 10 mg/kg fluconazole from week 16 of gestation for a total duration of 50 days. Adverse effects did not occur and the rest of the pregnancy proceeded favourably for both the mother and the baby.
authors.affiliation: Dept. of Internal Medicine I, University of Vienna Medical School, Austria.
authors.forename: E C
authors.initials: EC
authors.lastname: Wiesinger
authors.forename: S
authors.initials: S
authors.lastname: Mayerhofer
authors.forename: C
authors.initials: C
authors.lastname: Wenisch
authors.forename: S
authors.initials: S
authors.lastname: Breyer
authors.forename: W
authors.initials: W
authors.lastname: Graninger
mesh_terms: D000031:Abortion, Septic / Q000150:complications*; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D002176:Candida albicans / Q000302:isolation & purification*; D002177:Candidiasis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D009877:Endophthalmitis / Q000150:complications*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D012196:Review Literature as Topic; D018805:Sepsis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole