title: Putting a lid on protein folding: structure and function of the co-chaperonin, GroES.
abstract: The co-chaperonin GroES is an essential partner in protein folding mediated by the chaperonin, GroEL. Two recent crystal structures of GroES provide a structural basis to understand how GroES forms the lid on the folding-active cis ternary complex, and how the GroEL-GroES complex enhances folding.
authors.affiliation: Department of Genetics, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
authors.forename: W A
authors.initials: WA
authors.lastname: Fenton
authors.forename: J S
authors.initials: JS
authors.lastname: Weissman
authors.forename: A L
authors.initials: AL
authors.lastname: Horwich
mesh_terms: D018835:Chaperonin 10 / Q000737:chemistry* / Q000378:metabolism*; D011485:Protein Binding; D011487:Protein Conformation; D017510:Protein Folding; D013329:Structure-Activity Relationship
chemical_list: D018835:Chaperonin 10