Calcium signalling: sphingosine kinase versus phospholipase C?
A recent study shows that sphingosine kinase and its lipid product have an essential signalling function; they act in the mobilization of calcium ions in antigen-stimulated mast cells. This finding may have relevance to signalling in other cells of the immune system.
Beaven
M A
MA
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1760, USA. beaven@helix.nih.gov
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015394:Molecular Structure; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013107:Sphingolipids / Q000378:metabolism; D010738:Type C Phospholipases / Q000378:metabolism*; D000099157:Sphingosine Kinase
D002118:Calcium; D017853:Phosphotransferases (Alcohol Group Acceptor); D013107:Sphingolipids; D010738:Type C Phospholipases; D000099157:Sphingosine Kinase