title: The design and synthesis of substituted biphenyl libraries.
abstract: A novel scaffold system for the generation of diversity libraries has been designed which allows for rapid modification not only of functional groups, but their spatial arrangements as well. The biphenyl scaffold allows for display of three or four diverse functional groups in a wide variety of spatial arrangements depending on the substitution pattern selected. The libraries are generated by a combination of solution and solid-phase chemistries and are cleaved off the solid-support for screening.
authors.affiliation: Sphinx Pharmaceuticals, Eli Lilly and Company, Cambridge, MA 01239, USA.
authors.forename: M R
authors.initials: MR
authors.lastname: Pavia
authors.forename: M P
authors.initials: MP
authors.lastname: Cohen
authors.forename: G J
authors.initials: GJ
authors.lastname: Dilley
authors.forename: G R
authors.initials: GR
authors.lastname: Dubuc
authors.forename: T L
authors.initials: TL
authors.lastname: Durgin
authors.forename: F W
authors.initials: FW
authors.lastname: Forman
authors.forename: M E
authors.initials: ME
authors.lastname: Hediger
authors.forename: G
authors.initials: G
authors.lastname: Milot
authors.forename: T S
authors.initials: TS
authors.lastname: Powers
authors.forename: I
authors.initials: I
authors.lastname: Sucholeiki
authors.forename: S
authors.initials: S
authors.lastname: Zhou
authors.forename: D G
authors.initials: DG
authors.lastname: Hangauer
mesh_terms: D001713:Biphenyl Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D015195:Drug Design; D009682:Magnetic Resonance Spectroscopy
chemical_list: D001713:Biphenyl Compounds