A solution-phase strategy for the synthesis of chemical libraries containing small organic molecules: a universal and dipeptide mimetic template.
A general approach to the solution phase, parallel synthesis of chemical libraries, which allows the preparation of multi-milligram quantities of each individual member, is exemplified with both a universal and dipeptide mimetic template. In each step of the sequence, the reactants, unreacted starting material, reagents and their byproducts are removed by simple liquid/ liquid or liquid/solid extractions providing the desired intermediates and final compounds in high purities (> or = 90-100%) independent of the reaction yields and without deliberate reaction optimization.
Cheng
S
S
CombiChem, Inc., San Diego, CA 92121, USA.
Tarby
C M
CM
Comer
D D
DD
Williams
J P
JP
Caporale
L H
LH
Myers
P L
PL
Boger
D L
DL
D004151:Dipeptides / Q000138:chemical synthesis* / Q000592:standards*; D015195:Drug Design; D012996:Solutions / Q000737:chemistry; D013698:Templates, Genetic
D004151:Dipeptides; D012996:Solutions