Midazolam co-induction and laryngeal mask insertion.
We have studied the effect of alfentanil and midazolam+alfentanil on the conditions for laryngeal mask airway insertion in patients receiving propofol for induction of anaesthesia. Ninety unpremedicated. ASA 1 or 2 adult patients were randomly allocated to one of three groups: group P received propofol only (2.5 mg.kg-1); group PA received alfentanil (10 micrograms.kg-1) followed by propofol (1.25 mg.kg-1); group PMA received midazolam (0.04 mg.kg-1) and alfentanil (10 micrograms.kg-1) followed by propofol (1.25 mg.kg-1). Further boluses of propofol (0.25 mg.kg-1 every 15 s) were given if the initial dose was inadequate for induction of anaesthesia. Patients in the midazolam+alfentanil group required less propofol (p < 0.001), had better mouth opening (p < 0.001) and fewer undesired responses to laryngeal mask airway insertion (p < 0.001) than the other two groups.
Driver
I K
IK
Department of Anaesthesia, Ipswich Hospital, Suffolk.
Wiltshire
S
S
Mills
P
P
Lillywhite
N
N
Howard-Griffin
R
R
D000328:Adult; D015760:Alfentanil / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D017214:Laryngeal Masks; D008874:Midazolam / Q000008:administration & dosage*; D015742:Propofol / Q000008:administration & dosage
D006993:Hypnotics and Sedatives; D015760:Alfentanil; D008874:Midazolam; D015742:Propofol