Immunity to a challenge infection of Strongyloides stercoralis third-stage larvae in the jird.
Jirds support the entire life-cycle of Strongyloides stercoralis. We therefore used this host as a model to define the mechanism of the immune response to a challenge infection, as well as the parasite stage effected by the response. Jirds given a primary infection of S. stercoralis are resistant to re-infection. The use of implanted diffusion chambers containing larvae showed that the immune response killed the third-stage larvae, and this was confirmed by subcutaneous infections. The larvae of a challenge infection are killed within 48 h, a time period too short to allow for the development of L4 and adult worms. The immune response is dependent on both a serum factor and cells, suggestive of an ADCC type response.
Nolan
T J
TJ
Department of Pathobiology, University of Pennsylvania, Philadelphia 19104, USA.
Rotman
H L
HL
Bhopale
V M
VM
Schad
G A
GA
Abraham
D
D
D000818:Animals; D000969:Antinematodal Agents / Q000627:therapeutic use; D004195:Disease Models, Animal; D005849:Gerbillinae / Q000276:immunology / Q000469:parasitology; D007109:Immunity; D007559:Ivermectin / Q000627:therapeutic use; D007814:Larva; D008297:Male; D017171:Strongyloides stercoralis / Q000276:immunology*; D013322:Strongyloidiasis / Q000188:drug therapy / Q000276:immunology*
D000969:Antinematodal Agents; D007559:Ivermectin