How pathogens exploit interactions mediated by SH3 domains.
An important event in signal transduction is the binding of SH3 domains, found in viral proteins such as v-Src and v-Crk, to proline-rich sequences. Recently, proline-rich proteins that bind host-cell SH3 domains have been identified in a variety of pathogenic microorganisms. Exploitation of SH3-mediated interactions by pathogens may be more common than previously suspected.
Bliska
J
J
Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA.
D001419:Bacteria / Q000472:pathogenicity*; D002472:Cell Transformation, Viral; D010455:Peptides / Q000378:metabolism; D055232:Proline-Rich Protein Domains; D015398:Signal Transduction; D014764:Viral Proteins / Q000378:metabolism; D014780:Viruses / Q000472:pathogenicity*; D018909:src Homology Domains
D010455:Peptides; D014764:Viral Proteins