The activity of azithromycin on the infectivity of Chlamydia trachomatis in human amniotic cells.
The effects of azithromycin on the infectivity and growth of Chlamydia trachomatis were investigated in primary human amniotic epithelial cells. Infection was prevented when cultures were exposed to the drug 6 h after inoculation and growth was completely inhibited when the drug was added to cultures 24, 48, 72 h or 7 days after infection. The same inhibition was observed at 0.5, 1.0 and 5.0 mg/L. Ultrastructural observations depicted interruption in the growth cycle of the chlamydia and ghost-like envelopes were present in the near empty inclusions. Azithromycin is effective in inhibiting chlamydial growth no matter when treatment is initiated after infection.
Patton
D L
DL
Department of Obstetrics and Gynaecology, University of Washington, Seattle 98195, USA.
Wang
S K
SK
Kuo
C C
CC
D000650:Amnion / Q000166:cytology / Q000187:drug effects / Q000382:microbiology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001345:Autoradiography; D017963:Azithromycin / Q000494:pharmacology*; D002250:Carbon Radioisotopes; D002692:Chlamydia trachomatis / Q000187:drug effects* / Q000472:pathogenicity* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D011247:Pregnancy
D000900:Anti-Bacterial Agents; D002250:Carbon Radioisotopes; D017963:Azithromycin