title: Resorption kinetics of osseous substitute: natural coral and synthetic hydroxyapatite.
abstract: Coral and hydroxyapatite may be used as substitution biomaterials for bone grafts. In this work, we extracted the implants from the femora to study the kinetics of elementary mineral transformation of the osseous substitutes. The use of physical analysis methods such as PIXE (particle-induced X-ray emission) shows that coral and hydroxyapatite, after their implantation in vivo, reach a mineral composition comparable with that of bone. For the first time we have measured the concentration of mineral elements, at different time intervals after implantation, along a cross-section. The distribution according to mineral elements (Ca, P, Sr, Zn, Fe) in the implant, in the receiver site and also at the interface, showed that the kinetics of coral resorption was faster than that of hydroxyapatite; in the same way, the osseous attack was not global but, rather, centripetal.
authors.affiliation: Laboratoire de Physique Corpusculaire de Clermont-Ferrand, IN2P3/C.N.R.S. et Université Blaise Pascal, Aubiere, France.
authors.forename: F
authors.initials: F
authors.lastname: Braye
authors.forename: J L
authors.initials: JL
authors.lastname: Irigaray
authors.forename: E
authors.initials: E
authors.lastname: Jallot
authors.forename: H
authors.initials: H
authors.lastname: Oudadesse
authors.forename: G
authors.initials: G
authors.lastname: Weber
authors.forename: N
authors.initials: N
authors.lastname: Deschamps
authors.forename: C
authors.initials: C
authors.lastname: Deschamps
authors.forename: P
authors.initials: P
authors.lastname: Frayssinet
authors.forename: P
authors.initials: P
authors.lastname: Tourenne
authors.forename: H
authors.initials: H
authors.lastname: Tixier
authors.forename: S
authors.initials: S
authors.lastname: Terver
authors.forename: J
authors.initials: J
authors.lastname: Lefaivre
authors.forename: A
authors.initials: A
authors.lastname: Amirabadi
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000378:metabolism*; D018786:Bone Substitutes / Q000493:pharmacokinetics*; D017886:Durapatite / Q000493:pharmacokinetics*; D008422:Materials Testing / Q000295:instrumentation / Q000379:methods; D019736:Prostheses and Implants; D012756:Sheep; D013052:Spectrometry, X-Ray Emission; D013997:Time Factors
chemical_list: D018786:Bone Substitutes; D017886:Durapatite