Cellulose acetate butyrate microparticles for controlled release of carbamazepine.
Cellulose acetate butyrate microparticles loaded in carbamazepine were prepared by a solvent evaporation technique. A decrease of the amount of organic solvent (from 80 to 40 ml of methylene chloride) increased the microparticle average diameter (73-111 and 207 microns) and decreased the carbamazepine release rate (T50% increased from 3.3 to 16.8 and 166.4 min). The microparticle area under the curve at 120 min was similar to that obtained with Tegretol LP 200 tablets.
Arnaud
P
P
Faculté de Pharmacie de Paris, Laboratoire de Pharmacie Galénique, France.
Boué
C
C
Chaumeil
J C
JC
D002214:Capsules; D002220:Carbamazepine / Q000008:administration & dosage* / Q000737:chemistry; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D008752:Methylene Chloride; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D012967:Sodium Dodecyl Sulfate; D012995:Solubility; D012997:Solvents; D013501:Surface-Active Agents
D002214:Capsules; D003692:Delayed-Action Preparations; D011108:Polymers; D012997:Solvents; D013501:Surface-Active Agents; D002220:Carbamazepine; D012967:Sodium Dodecyl Sulfate; D008752:Methylene Chloride; D002482:Cellulose; C014396:cellulose acetate-butyrate