title: Evaluation of amblyopic scotoma by electrophysiological examinations and computerized perimetry.
abstract: To evaluate amblyopic scotoma and the most affected neural cells in suppressive phenomena, eight patients with deep amblyopia from strabismus (visual acuity of the amblyopic eye between 4/50 and 2/10) underwent a pattern electroretinogram (PERG), pattern visual evoked potential (VEP), and event-related potential (ERP) from visual stimuli, and computerized perimetry. The results of stimulation of the amblyopic eye, the leading eye and the leading eye penalized by Ryser filters were compared statistically. Computerized perimetry was used to quantify the depth and amplitude of the amblyopic scotoma. All electrophysiological potentials were reduced in amplitude and the implicit times of VEP and ERP were longer when stimulating the amblyopic eye compared to the leading eye. Only in PERG the penalization induced major changes. Our data suggest that the important suppressive phenomena present in the squint amblyopic eye involve not only the occipital cortex, but also the cognitive areas.
authors.affiliation: University Eye Clinic of Genova, S. Martino Hospital, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Fioretto
authors.forename: E
authors.initials: E
authors.lastname: Gandolfo
authors.forename: C
authors.initials: C
authors.lastname: Burtolo
authors.forename: C
authors.initials: C
authors.lastname: Orione
authors.forename: G P
authors.initials: GP
authors.lastname: Fava
authors.forename: G
authors.initials: G
authors.lastname: Calabria
authors.forename: M
authors.initials: M
authors.lastname: Zingirian
mesh_terms: D000293:Adolescent; D000328:Adult; D000550:Amblyopia / Q000209:etiology / Q000503:physiopathology*; D002648:Child; D004596:Electroretinography / Q000379:methods; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation; D012607:Scotoma / Q000209:etiology / Q000503:physiopathology*; D013285:Strabismus / Q000150:complications* / Q000503:physiopathology; D014792:Visual Acuity; D058609:Visual Field Tests / Q000379:methods*; D014794:Visual Fields