Lymphocyte dynamics, apoptosis and HIV infection.
Death of HIV-infected CD4+ cells and HIV-induced death of uninfected CD4+ cells by apoptosis have been suggested to be important factors in causing the gradual progressive decline of CD4+ cells in the blood of HIV-positive patients. Recent advances in our knowledge of the dynamics of infection and the mechanism of apoptosis are reviewed with the aid of a mathematical model.
Frost
S D
SD
Department of Zoology, Oxford University, UK, sfrost@vax.ox.ac.uk
Michie
C A
CA
D017209:Apoptosis; D015496:CD4-Positive T-Lymphocytes / Q000821:virology*; D006678:HIV / Q000276:immunology / Q000472:pathogenicity; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007700:Kinetics; D018448:Models, Immunological; D014779:Virus Replication