Regulation of CTL recognition by receptors for HLA-DR molecules.
NK cells and some T cells have receptors for MHC class I molecules that negatively regulate the recognition of these cells. In the present study, we show alpha beta CTL clones carrying the receptors for HLA-DR molecules that inhibit this cytotoxicity. The cytotoxicity of two CTL clones possessing NK activity was inhibited by the surface expression of HLA-DR and HLA class I molecules on the target cells. The inhibitory effect of DR molecules on the cytotoxicity of the CTL clones was confirmed by using T2 transfectants expressing HLA-DR3. These results suggest that receptors for both HLA-DR and HLA class I molecules negatively regulate the recognition of T cells.
Nakajima
H
H
Department of Tumor Biology, Institute of Medical Science, University of Tokyo, Japan.
Takiguchi
M
M
D017951:Antigen Presentation; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D015536:Down-Regulation / Q000276:immunology; D006684:HLA-DR Antigens / Q000378:metabolism*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors / Q000502:physiology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000378:metabolism*
D006684:HLA-DR Antigens; D011971:Receptors, Immunologic