Brain natriuretic peptide and cyclic guanosine-3',5' monophosphate in pre-eclampsia.
The objective of this study is to determine the possibility that pre-eclampsia, a disease characterized by altered vascular tone, may result in altered levels of fetal BNP and cGMP, and to determine whether pre-eclampsia alters the maternal-fetal relationship of BNP and cGMP. Paired maternal and umbilical venous plasma levels of BNP and cGMP were determined in 13 pre-eclamptic and 9 normotensive primigravidas in the third trimester. Statistical analysis was performed using multivariate analysis of variance, linear regression, and canonical correlation. Overall, levels of cGMP were lower in pre-eclampsia (P < 0.03). Pre-eclampsia was also associated with an altered maternal-fetal relationship for BNP and cGMP (P < 0.008, P < 0.02, respectively). With pre-eclampsia, the maternal:fetal ratio was reduced for BNP and was increased for cGMP. Because of its role as a second messenger for many vasoactive hormones, we hypothesize that fetal cGMP levels may better reflect overall vascular tone than do individual hormones. Altered BNP and cGMP maternal-fetal homeostasis raises the possibility of maternal-fetal coordination of vascular control.
Lauria
M R
MR
Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA.
Standley
C A
CA
Sorokin
Y
Y
Todt
J C
JC
Bottoms
S F
SF
Yelian
F D
FD
Cotton
D B
DB
D015415:Biomarkers / Q000097:blood; D006152:Cyclic GMP / Q000097:blood*; D005260:Female; D005312:Fetal Blood; D005333:Fetus; D006801:Humans; D007743:Labor, Obstetric / Q000097:blood; D008431:Maternal-Fetal Exchange; D020097:Natriuretic Peptide, Brain; D009419:Nerve Tissue Proteins / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third / Q000097:blood*; D012016:Reference Values; D014471:Umbilical Veins
D015415:Biomarkers; D009419:Nerve Tissue Proteins; D020097:Natriuretic Peptide, Brain; D006152:Cyclic GMP