title: Evaluation of serum and tissue levels of alpha-tocopherol.
abstract: This study was designed to test the effect of supplementation of several antioxidants, including alpha-tocopherol, on the clinical reduction of premalignant oral lesions. Samples of oral mucosa and serum were taken from baseline to 9 months of supplementation from patients with premalignant oral lesions and analyzed for alpha-tocopherol by HPLC. Statistical increases in both serum and tissue alpha-tocopherol were found after supplementation. There was no statistical relationship between alpha-tocopherol and beta-carotene levels.
authors.affiliation: Department of Biochemistry, Medical College of Virginia/Virginia Commonwealth University, Richmond, Virginia, 23298, USA.
authors.forename: R B
authors.initials: RB
authors.lastname: Brandt
authors.forename: G E
authors.initials: GE
authors.lastname: Kaugars
authors.forename: W T
authors.initials: WT
authors.lastname: Riley
authors.forename: R A
authors.initials: RA
authors.lastname: Bei
authors.forename: S
authors.initials: S
authors.lastname: Silverman
authors.forename: J G
authors.initials: JG
authors.lastname: Lovas
authors.forename: B P
authors.initials: BP
authors.lastname: Dezzutti
authors.forename: W
authors.initials: W
authors.lastname: Chan
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D009059:Mouth Diseases / Q000188:drug therapy* / Q000473:pathology; D009061:Mouth Mucosa / Q000473:pathology*; D011230:Precancerous Conditions / Q000188:drug therapy* / Q000473:pathology; D012737:Sex Factors; D016896:Treatment Outcome; D019207:beta Carotene / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D019207:beta Carotene