Two selectins converge on sulphate. Leukocyte adhesion.
Selectins mediate the attachment of leukocytes to endothelial cells and to platelets under conditions of blood flow. Sulphation of the ligands for two of the selectins is required for optimal cell-cell interactions.
Rosen
S D
SD
Department of Anatomy and Program in Immunology, University of California, San Francisco, 94143-0452, USA.
Bertozzi
C R
CR
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D002240:Carbohydrate Sequence; D002448:Cell Adhesion; D004727:Endothelium / Q000166:cytology; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D008969:Molecular Sequence Data; D019087:Selectins / Q000378:metabolism*; D013431:Sulfates / Q000378:metabolism*
D019087:Selectins; D013431:Sulfates