title: New evidence for the involvement of oxygen radicals in triggering neonatal chronic lung disease.
abstract: We measured the plasma concentration of allantoin, an oxidation product of uric acid and an "in vivo" marker of free radical generation, within 24-48 h after birth in 10 premature infants who subsequently developed chronic lung disease (CLD) and 9 infants without CLD (non-CLD). The plasma allantoin level (mean +/- SD, 25.9 +/- 9.8 microM for CLD versus 11.0 +/- 5.7 microM for non-CLD, p < 0.01) and the allantoin/urate ratio (5.8 +/- 2.0% for CLD infants versus 2.4 +/- 0.9% for non-CLD infants, p < 0.01) were significantly higher in the CLD group than those in the non-CLD group. These observations suggest the possible involvement of oxygen radicals in triggering CLD. In addition, the plasma allantoin concentration and the allantoin/urate ratio may be useful early predictors of the development of CLD.
authors.affiliation: Department of Pediatrics, Osaka Medical College, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ogihara
authors.forename: R
authors.initials: R
authors.lastname: Okamoto
authors.forename: H S
authors.initials: HS
authors.lastname: Kim
authors.forename: A
authors.initials: A
authors.lastname: Nagai
authors.forename: T
authors.initials: T
authors.lastname: Morinobu
authors.forename: H
authors.initials: H
authors.lastname: Moji
authors.forename: H
authors.initials: H
authors.lastname: Kamegai
authors.forename: K
authors.initials: K
authors.lastname: Hirano
authors.forename: H
authors.initials: H
authors.lastname: Ogihara
authors.forename: H
authors.initials: H
authors.lastname: Tamai
authors.forename: M
authors.initials: M
authors.lastname: Mino
mesh_terms: D000481:Allantoin / Q000097:blood*; D002908:Chronic Disease; D005260:Female; D005609:Free Radicals; D006801:Humans; D007231:Infant, Newborn; D008171:Lung Diseases / Q000209:etiology*; D008297:Male; D010100:Oxygen; D014527:Uric Acid / Q000097:blood*
chemical_list: D005609:Free Radicals; D014527:Uric Acid; D000481:Allantoin; D010100:Oxygen