title: [Treatment of arteriosclerotic obstruction by blood purification].
abstract: Almost a half of the patients with arteriosclerotic obstruction in the lower extremities is complicated with dyslipidemia (a blood total cholesterol level > or = 220 mg/dl and/or LDL cholesterol level > or = 140 mg/dl). Currently available plasma purification technics which actively correct dyslipidemia are whole-plasma exchange, double filtration plasmapheresis and LDL adsorption. However, because of the advantage in specificity in removal of LDL cholesterol, the LDL adsorption is most frequently applied in clinical practice. As a result of the LDL adsorption treatment, ten procedures for approximately 3 months as a usual treatment, course, sch as warmness, amelioration in pain and/or disappearance of ulcer in the lower extremities, elongation of a walk distance are obtained. Normalization of a total and LDL cholesterol level is also achieved. A rise in extremity temperature and improvement in plethysmograph are observed. These favorite effects are maintained in 80 to 90% of the patients so treated, respectively in different symptoms even averagely 1.2 years after a completion of the treatment course.
authors.affiliation: Kidney Center, Tokyo Women's Medical College, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Agishi
mesh_terms: D001162:Arteriosclerosis Obliterans / Q000097:blood / Q000628:therapy*; D008078:Cholesterol, LDL / Q000097:blood; D006464:Hemoperfusion; D006801:Humans
chemical_list: D008078:Cholesterol, LDL