title: Failure of buflomedil to improve wound healing in ischaemic skin flaps.
abstract: The effect of buflomedil and isoxsuprine on the healing of ischaemic wounds was investigated using an ischaemic flap model previously evaluated on rats. The drugs were given twice daily intraperitoneally for a total of nine days starting on the day before operation. The wounds were tested biomechanically after 10 and 20 days of healing, respectively, and the length of surface necrosis on the flaps was measured after 10 days. The study showed no differences in any of the biomechanical (functional) parameters of the ischaemic wounds compared with the control groups, either after 10 or 20 days of healing. There were no differences in the length of surface necrosis on the flaps. Neither of these drugs has so far convincingly proved to be effective in the treatment of ischaemic wounds or flaps.
authors.affiliation: Department of Connective Tissue Biology, University of Aarhus, Denmark.
authors.forename: A
authors.initials: A
authors.lastname: Quirinia
authors.forename: F
authors.initials: F
authors.lastname: Gottrup
authors.forename: A
authors.initials: A
authors.lastname: Viidik
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000818:Animals; D007511:Ischemia / Q000188:drug therapy*; D007556:Isoxsuprine / Q000627:therapeutic use*; D008297:Male; D009336:Necrosis; D011759:Pyrrolidines / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013524:Surgical Flaps / Q000098:blood supply* / Q000473:pathology; D013718:Tensile Strength; D014665:Vasodilator Agents / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000317:Adrenergic alpha-Antagonists; D011759:Pyrrolidines; D014665:Vasodilator Agents; D007556:Isoxsuprine; C010651:buflomedil