title: [Atherosclerosis obliterance; thrombolytic therapy].
abstract: Thrombolytic therapy used to be considered ineffective for chronic arteriosclerotic obiterance. However, direct infusion of a thrombotic agent into the thrombus through a vascular catheter was shown to be more effective than expected. We have performed high-dose intra-thrombotic urokinase injection for arteriosclerotic obiterance of iliac and femoropopliteal arterial region since 1985. In this procedure, urokinase is infused at 10,000 unit/ minute through a catheter inserted into the thrombus. In the 65 lesions treated by this method, the initial success rate was 85%, and the cumulative 1-year patency rate was 72%. The mean total dose of urokinase was 620,000 units. Here we discussed thrombolytic therapy for chronic arteriosclerosis obliterance based on our experience.
authors.affiliation: Deparment of Radiology, Wakayama Medical College, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Terada
authors.forename: R
authors.initials: R
authors.lastname: Yamada
mesh_terms: D001162:Arteriosclerosis Obliterans / Q000188:drug therapy*; D002406:Catheterization, Peripheral; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D006801:Humans; D015912:Thrombolytic Therapy / Q000379:methods; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D014568:Urokinase-Type Plasminogen Activator