Interferon-alpha induces renal dysfunction and injury.
Interferon-alpha has been used extensively as a therapeutic agent for several clinically relevant diseases. Although some success has been achieved by using this agent to treat viral diseases and malignancy, there are serious side effects on different organ systems, including the kidney. This review examines the evidence that establishes that interferon-alpha can be either directly nephrotoxic or involved in other pathophysiological processes which can lead to renal dysfunction and injury.
Phillips
T M
TM
Immunochemistry Laboratory, Division of Renal Diseases and Hypertension, Washington, DC 20037, USA.
D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects*; D016898:Interferon-alpha / Q000009:adverse effects*; D007668:Kidney / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D009369:Neoplasms / Q000628:therapy; D011994:Recombinant Proteins; D014777:Virus Diseases / Q000628:therapy
D007370:Interferon Type I; D016898:Interferon-alpha; D011994:Recombinant Proteins