title: The effects of continuous versus interrupted noise exposures on distortion product otoacoustic emissions in guinea pigs.
abstract: Distortion product otoacoustic emissions (DPOAE) were measured serially in guinea pigs before and following 4-h exposures to a half-octave band of noise centered at 6 kHz. Stimulus parameters used to elicit the DPOAE were f2/f1 = 1.26 and L2 = L1-10. The 80 dB SPL exposures resulted in attenuation of emissions, which was maximal at the frequency one-half octave above the exposure when referenced to the f2 stimulus, and which recovered back to baseline after 2 days. The 90 dB SPL exposures resulted in a permanent deficit in emissions elicited by high-frequency stimuli, as measured after 8 days of recovery. A statistically significant difference was also found between animals exposed continuously for 4 h versus animals given two 2-h exposures separated by a 1-h break. Measures of f2-f1 and 3f1-2f2 indicated that they were more sensitive than 2f1-f2 to alterations in cochlear function after noise exposure.
authors.affiliation: Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology, University of Washington School of Medicine, Seattle, WA 98195, USA. kchang@u. washington.edu
authors.forename: K W
authors.initials: KW
authors.lastname: Chang
authors.forename: S J
authors.initials: SJ
authors.lastname: Norton
mesh_terms: D000161:Acoustic Stimulation; D000704:Analysis of Variance; D000818:Animals; D001309:Auditory Threshold / Q000502:physiology; D003051:Cochlea / Q000502:physiology; D003055:Cochlear Microphonic Potentials / Q000502:physiology; D006168:Guinea Pigs; D009622:Noise / Q000009:adverse effects*; D017084:Otoacoustic Emissions, Spontaneous