Molecular aspects of osteoclast function.
In this article we have overviewed recent important advances in understanding the molecular mechanisms involved in osteoclastic bone resorption. Specifically, new findings relating to osteoclast activation and the process of bone resorption are reviewed and a current overall model of how osteoclasts resorb bone is presented. Controversial research topics concerning the regulation of osteoclast activity are also critically discussed.
Hall
T J
TJ
Research Department, Ciba-Geigy Ltd., Basel, Switzerland.
Chambers
T J
TJ
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001862:Bone Resorption; D002403:Cathepsins / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000502:physiology; D009569:Nitric Oxide / Q000378:metabolism; D010010:Osteoclasts / Q000502:physiology*; D053495:Osteopontin; D017382:Reactive Oxygen Species / Q000378:metabolism; D012795:Sialoglycoproteins / Q000502:physiology
D016023:Integrins; D017382:Reactive Oxygen Species; C506895:SPP1 protein, human; D012795:Sialoglycoproteins; D053495:Osteopontin; D009569:Nitric Oxide; D002403:Cathepsins; D000251:Adenosine Triphosphatases