title: Correlation of intrinsic DNA curvature with DNA property periodicity.
abstract: Twelve di- and trinucleotide parameter sets representing various structural, thermodynamic or bendability-related properties of DNA were tested in the prediction of DNA curvature applying Fourier analysis on curved and straight, A/T-type or G/C-type DNA sequence motifs. The best predictions were obtained with a new consensus bendability scale created by combining a nucleosome-based and a deoxyribonuclease I-based parameter set. Geometry calculations on the same sequences showed that the helical parameters derived from NMR structures can correctly predict curvature, as distinct from the parameters derived from X-ray crystallographic analysis.
authors.affiliation: International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Gabrielian
authors.forename: S
authors.initials: S
authors.lastname: Pongor
mesh_terms: D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D005583:Fourier Analysis; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009690:Nucleic Acid Conformation
chemical_list: D004247:DNA