title: Antibacterial activity of the phenolic acids fractions of Scrophularia frutescens and Scrophularia sambucifolia.
abstract: The phenolic fractions of aerial part of Scrophularia frutescens and S. sambucifolia (Scrophulariaceae) showed a potent antibacterial activity. Ferulic, isovanillic, p-hydroxycinnamic, p-hydroxybenzoic, syringic, caffeic, gentisic and protocatechuic acids were isolated from S. frutescens and ferulic, p-coumaric, vanillic, p-hydroxibenzoic and syringic acids were isolated from S. sambucifolia. Since phenolic acids have been shown in the literature to exert an antibacterial effect, the presence of these compounds in the two plants explains their antibacterial activity.
authors.affiliation: Laboratorio de Farmacognosia, Facultad de Farmacia, Universidad de Sevilla, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Fernández
authors.forename: M D
authors.initials: MD
authors.lastname: García
authors.forename: M T
authors.initials: MT
authors.lastname: Sáenz
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D001407:Bacillus / Q000187:drug effects / Q000378:metabolism; D002109:Caffeic Acids / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D005591:Chemical Fractionation; D003373:Coumaric Acids / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D005707:Gallic Acid / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D005841:Gentisates; D062385:Hydroxybenzoates / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D009016:Moraxella / Q000187:drug effects / Q000378:metabolism; D010226:Parabens / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D010936:Plant Extracts / Q000378:metabolism / Q000494:pharmacology*; D010946:Plants, Medicinal; D011422:Propionates; D012486:Salmonella typhimurium / Q000187:drug effects / Q000378:metabolism; D012706:Serratia marcescens / Q000187:drug effects / Q000378:metabolism; D013329:Structure-Activity Relationship; D014641:Vanillic Acid / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D002109:Caffeic Acids; D003373:Coumaric Acids; D016166:Free Radical Scavengers; D005841:Gentisates; D062385:Hydroxybenzoates; D010226:Parabens; D010936:Plant Extracts; D011422:Propionates; C009091:protocatechuic acid; D005707:Gallic Acid; C045317:isovanillic acid; C004999:ferulic acid; C001945:syringic acid; D014641:Vanillic Acid; C495469:p-coumaric acid; C038193:4-hydroxybenzoic acid; C040048:caffeic acid; C010925:2,5-dihydroxybenzoic acid