title: Early tumour response and treatment toxicity after hyperfractionated radiotherapy in nasopharyngeal carcinoma.
abstract: The aim of the present study was to undertake a planned interim analysis of a prospective randomized trial comparing the tumour response and the acute and subacute complications of hyperfractionated radiotherapy and conventional radiotherapy in non-metastatic nasopharyngeal carcinoma (NPC). 100 patients with newly diagnosed non-metastatic NPC were randomized to receive either conventional radiotherapy (Arm I) or hyperfractionated radiotherapy (Arm II). Stratification was done according to the T-Stage (modified Ho's T-Stage classification). The biological effective dose (10 Gy) to the primary and the upper cervical lymphatics were 75.0 and 73.1 for Arm I and 84.4 and 77.2 for Arm II, respectively. Hyperfractionated radiotherapy was associated with significant mucositis which is of higher grade than conventional radiotherapy (p = 0.0001), but the duration of mucositis was similar between the two Arms and all study patients completed radiotherapy on schedule without interruption of radiotherapy. Early survival and tumour recurrence rates were comparable between the Arms. The preliminary results indicate that the hyperfractionated radiotherapy has excellent patient compliance in Chinese patients, with acceptable acute and subacute toxicities and the local and regional complete tumour response rates being comparable with conventional radiotherapy. The significance of the time required after start of radiotherapy to achieve a complete tumour response is discussed.
authors.affiliation: Clinical Oncology Department, Prince of Wales Hospital, Hong Kong.
authors.forename: P M
authors.initials: PM
authors.lastname: Teo
authors.forename: W H
authors.initials: WH
authors.lastname: Kwan
authors.forename: S F
authors.initials: SF
authors.lastname: Leung
authors.forename: W T
authors.initials: WT
authors.lastname: Leung
authors.forename: A
authors.initials: A
authors.lastname: Chan
authors.forename: P
authors.initials: P
authors.lastname: Choi
authors.forename: P
authors.initials: P
authors.lastname: Yu
authors.forename: W Y
authors.initials: WY
authors.lastname: Lee
authors.forename: P
authors.initials: P
authors.lastname: Johnson
mesh_terms: D002277:Carcinoma / Q000532:radiotherapy*; D018572:Disease-Free Survival; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy*; D011446:Prospective Studies; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods; D011879:Radiotherapy Dosage; D016896:Treatment Outcome