The state of the union. Neuromuscular junction.
Synaptic differentiation is triggered by signals from the ingrowing axon and is shaped by information exchange between the presynaptic and postsynaptic cells. The central role of agrin in this process, and the identity of the signaling component of its receptor, have now been established.
Wells
D G
DG
Department of Neuroscience, Brown University, 190 Thayer Street, Box 1953, Providence, Rhode Island 02912, USA. David_Wells@Brown.edu
Fallon
J R
JR
D018171:Agrin / Q000378:metabolism / Q000502:physiology; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D004789:Enzyme Activation; D009132:Muscles / Q000201:enzymology; D009469:Neuromuscular Junction / Q000502:physiology*; D010770:Phosphotransferases / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D011950:Receptors, Cholinergic / Q000235:genetics; D015398:Signal Transduction; D013569:Synapses / Q000378:metabolism
D018171:Agrin; D012333:RNA, Messenger; D011950:Receptors, Cholinergic; D010770:Phosphotransferases