Structural basis of autoimmunity against G protein coupled membrane receptors.
The structural basis of the function of G protein coupled membrane receptors will be considered taking the beta 2-adrenergic receptor as model. The immunogenicity and antigenicity of the same receptor will be studied to examine the immunological properties of the G protein coupled membrane receptors. From the two first parts will be derived the conditions which could lead to the building-up of a functional autoimmune response. Finally, the possible application of the structural knowledge on antibody-receptor interactions will be discussed.
Hoebeke
J
J
UFR Sciences Pharmaceutiques, Université François Rabelais, Tours, France.
D000818:Animals; D015551:Autoimmunity / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000276:immunology / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins / Q000276:immunology / Q000502:physiology; D051379:Mice
D008565:Membrane Proteins; D019204:GTP-Binding Proteins