Oxygen radical formation due to the effect of varying hydrogen ion concentrations on cytochrome P450-catalyzed cyclosporine metabolism in rat and human liver microsomes.
Ahmed
S S
SS
Department of Biochemistry/Molecular Biology, The University of Texas Health Science Center, Houston 77225, USA.
Napoli
K L
KL
Strobel
H W
HW
D000323:Adrenochrome / Q000096:biosynthesis; D000818:Animals; D001589:Benzphetamine / Q000378:metabolism; D000697:Central Nervous System Stimulants / Q000378:metabolism; D016572:Cyclosporine / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007166:Immunosuppressive Agents / Q000378:metabolism*; D066298:In Vitro Techniques; D008315:Malondialdehyde / Q000378:metabolism; D008862:Microsomes, Liver / Q000201:enzymology*; D009245:NADH Dehydrogenase / Q000378:metabolism; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism*
D000697:Central Nervous System Stimulants; D007166:Immunosuppressive Agents; D017382:Reactive Oxygen Species; D001589:Benzphetamine; D008315:Malondialdehyde; D000323:Adrenochrome; D016572:Cyclosporine; D003577:Cytochrome P-450 Enzyme System; D009245:NADH Dehydrogenase