title: Catheter-related complications of cancer therapy.
abstract: Although the management of CVC-related infection appears complex and at times the literature seems to be contradictory, simple guidelines can direct the clinician in a stepwise fashion. Knowledge of the pathogenesis of each organism and the immune status of the host is crucial to decide whether catheter removal or retention is indicated. For example, in general, GNB bacteremia does not immediately prompt catheter removal in a neutropenic patient but does in a nonneutropenic host because of the gastrointestinal source of the former and a primary catheter source in the latter. In summary, as more CVCs are inserted in patients undergoing chemotherapeutic, antimicrobial, transfusional, and nutritional supportive care, novel approaches to prevention and treatment of the associated infectious complications inherent with such devices are needed. A multifaceted approach from impregnated catheters to local catheter-site antisepsis was reviewed. We may find, however, that as simple handwashing between patients is crucial to infection control, so too is a trained catheter-care team using total barrier precautions and ensuring proper local catheter maintenance critical to preventing CVC-related infections.
authors.affiliation: Division of Infectious Diseases, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
authors.forename: J N
authors.initials: JN
authors.lastname: Greene
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000517:prevention & control; D002177:Candidiasis / Q000188:drug therapy / Q000517:prevention & control; D002404:Catheterization / Q000009:adverse effects*; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000295:instrumentation; D002406:Catheterization, Peripheral / Q000009:adverse effects; D016983:Enterococcus / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000517:prevention & control; D016908:Gram-Positive Bacterial Infections / Q000517:prevention & control; D006801:Humans; D007239:Infections / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D009181:Mycoses / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy; D018805:Sepsis / Q000209:etiology / Q000517:prevention & control; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents