Simultaneous administration of neuromedin B-10 and gastrin-releasing peptide(1-27) reproduces the satiating and microstructural effects of bombesin.
Bombesin (BN) suppresses food intake more than an equimolar dose of neuromedin B-10 (NMB-10) or gastrin-releasing peptide(1-27) [GRP(1-27)]. Because BN is active at both NMB- and GRP-preferring receptors, it is possible that its greater potency is due to the simultaneous activation of both receptor subtypes. This hypothesis was tested by administering a mixture of NMB-10 and GRP(1-27). The results were consistent with our hypothesis: administration of the mixture of NMB-10 and GRP(1-27) produced an inhibition of intake volume and total licks equivalent to that seen after an equimolar dose of BN and resulted in similar changes in the rate and pattern of licking.
Stratford
T R
TR
Department of Psychiatry, Cornell University Medical College, White Plains, NY 10605, USA.
Gibbs
J
J
Smith
G P
GP
D000818:Animals; D001839:Bombesin / Q000494:pharmacology*; D004347:Drug Interactions; D004435:Eating / Q000187:drug effects; D019886:Gastrin-Releasing Peptide; D008297:Male; D015287:Neurokinin B / Q000008:administration & dosage / Q000031:analogs & derivatives*; D010455:Peptides / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012527:Satiation / Q000187:drug effects*
D010455:Peptides; D019886:Gastrin-Releasing Peptide; D015287:Neurokinin B; C038393:neuromedin B; D001839:Bombesin