Mitomycin-C and lonidamine as second-line therapy for colorectal cancer: a phase II study.
OBJECTIVE
Recent preclinical data have suggested that lonidamine may potentiate the acitivity of mitomycin C in human colon cancer cell lines LoVo and HT29.


METHODS
A phase II study was carried out in 14 patients with advanced colorectal cancer pretreated with fluorouracil and folinic acid. Treatment consisted of lonidamine, 600 mg po, followed after 2 h by mitomycin, 20 mg/m2 by iv bolus, followed by lonidamine, 150 mg tio for 5 days; the cycle was repeated every 6 weeks.


RESULTS
No objective response was seen. Three patients had stable disease; the median survival for the whole group was 4 months. Although hematologic toxicity was negligible, lonidamine-related side effects were moderate to severe in most patients and mainly represented by myalgia and gastric pain.


CONCLUSIONS
Despite a sound preclinical rationale, this schedule of lonidamine and mitomycin C was ineffective and toxic in patients with advanced colorectal cancer. More experimental data about lonidamine are needed in order to design more effective regimens based on the combination of this interesting drug with other anticancer agents.
Zaniboni
A
A
Servizio di Oncologia, Spedali Civili, Brescia, Italy.
Meriggi
F
F
Alghisi
A
A
Mutti
S
S
Distefano
L
L
Rizzi
A
A
Bettini
L
L
Simoncini
E
E
Marpicati
P
P
Montini
E
E
D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007191:Indazoles / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D010865:Pilot Projects; D016896:Treatment Outcome
D000903:Antibiotics, Antineoplastic; D007191:Indazoles; D016685:Mitomycin; C016371:lonidamine