title: Iron status following trauma, excluding burns.
abstract: Serum concentration of iron, transferrin saturation and total iron binding capacity (TIBC) were measured on days 1, 2, 3, 5, 7, 10 and 13 in 36 Thai patients with trauma (burns excluded) to determine temporal changes in iron metabolism. Throughout the study profound hypoferraemia was observed in association with decreased transferrin saturation. TIBC, in contrast, did not differ significantly from that in controls. These findings confirm previous reports which describe altered iron metabolism in association with an adverse event, a response known as 'stress hypoferraemia', and extends these observations to non-burned patients with trauma. The degree of hypoferraemia in patients in this study was not related to sepsis, Injury Severity Score, volume of blood transfused or surgery, suggesting that hypoferraemia following trauma is an independent event. The recognition of rapid and prolonged iron sequestration provides insight into the clinical condition of patients with trauma.
authors.affiliation: Division of Surgery, Walter Reed Army Institute of Research, Washington, DC, USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Walsh
authors.forename: K
authors.initials: K
authors.lastname: Pattanapanyasat
authors.forename: P
authors.initials: P
authors.lastname: Lamchiagdhase
authors.forename: P
authors.initials: P
authors.lastname: Siritongtaworn
authors.forename: P
authors.initials: P
authors.lastname: Thavichaigarn
authors.forename: N
authors.initials: N
authors.lastname: Jiarakul
authors.forename: C
authors.initials: C
authors.lastname: Chuntrasakul
authors.forename: C
authors.initials: C
authors.lastname: Komoltri
authors.forename: C
authors.initials: C
authors.lastname: Dheeradhada
authors.forename: F C
authors.initials: FC
authors.lastname: Pearce
authors.forename: W P
authors.initials: WP
authors.lastname: Wiesmann
authors.forename: H K
authors.initials: HK
authors.lastname: Webster
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D007501:Iron / Q000097:blood / Q000378:metabolism*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000209:etiology; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology; D013997:Time Factors; D014168:Transferrin / Q000378:metabolism; D014949:Wounds, Nonpenetrating / Q000097:blood / Q000378:metabolism*
chemical_list: D014168:Transferrin; D007501:Iron