title: [Effect of clarithromycin on symptoms and mucociliary transport in patients with sino-bronchial syndrome].
abstract: The effect of clarithromycin on symptoms and on mucociliary transport (as assessed by the saccharin test) were studied in 32 patients with sino-bronchial syndrome. Before treatment with clarithromycin, the nasal clearance time was significantly longer in these patients (70.3 +/- 64.7 min, mean +/- SD) than in control subjects (11.9 +/- 5.3 min, p < 0.001). By the end of 4 weeks of treatment with oral clarithromycin (400 mg/day), nasal clearance time in the patients had improved significantly (30.4 +/- 39.5 min, p < 0.001). Before clarithromycin therapy, bacteria were found in cultures of sputum from 15 patients. After clarithromycin therapy, bacteria were found in cultures of sputum from only 3 of those 15 patients. Cough frequency, volume of sputum, and dyspnea on exertion were significantly improved by clarithromycin therapy. These findings suggest that mucociliary transport is abnormal in patients with sino-bronchial syndrome, and that clarithromycin can be clinically useful in these patients.
authors.affiliation: Division of Pulmonary Medicine, Ishikawa Prefectural Central Hospital, Kanazawa, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nishi
authors.forename: M
authors.initials: M
authors.lastname: Mizuguchi
authors.forename: H
authors.initials: H
authors.lastname: Tachibana
authors.forename: T
authors.initials: T
authors.lastname: Ooka
authors.forename: T
authors.initials: T
authors.lastname: Amemiya
authors.forename: S
authors.initials: S
authors.lastname: Myou
authors.forename: M
authors.initials: M
authors.lastname: Fujimura
authors.forename: T
authors.initials: T
authors.lastname: Matsuda
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001982:Bronchial Diseases / Q000188:drug therapy* / Q000503:physiopathology; D002908:Chronic Disease; D017291:Clarithromycin / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000187:drug effects*; D012852:Sinusitis / Q000188:drug therapy* / Q000503:physiopathology; D013577:Syndrome
chemical_list: D000900:Anti-Bacterial Agents; D017291:Clarithromycin