Transient paroxysmal dystonia in an infant possibly induced by cisapride.
The case is reported of an infant presenting paroxysmal dystonia during cisapride theraphy. We suggest that this drug, a substituted benzamide, probably interfered with the age-related modification of striatal neurotransmitters, provoking extrapyramidal symptoms. Considering the widespread use of cisapride in early infancy for the treatment of gastrointestinal disorders, attention must be drawn to this possible side effect.
Angelini
L
L
Divisione di Neuropsichiatria Infantile, Istituto Nazionale Neurologico, C. Besta, Milano, Italy.
Zorzi
G
G
Rumi
V
V
Nardocci
N
N
Mennini
T
T
D020117:Cisapride; D004421:Dystonia / Q000139:chemically induced* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007223:Infant; D010880:Piperidines / Q000009:adverse effects*; D011379:Prognosis
D010880:Piperidines; D020117:Cisapride