title: Axonal interactions regulate Schwann cell apoptosis in developing peripheral nerve: neuregulin receptors and the role of neuregulins.
abstract: Programmed cell death during development resulting from the lack of appropriate survival factors has been demonstrated in both neurons and oligodendrocytes and occurs mostly in the form of apoptosis. We now demonstrate that Schwann cells in the rat sciatic nerve undergo apoptosis during early postnatal development and that the amount of apoptosis is markedly increased by axotomy. The apoptotic Schwann cells express the low-affinity nerve growth factor receptor but not myelin-related proteins, indicating that they are in the premyelinating state. Apoptosis resulting from normal development or from axotomy can be inhibited markedly by exogenous neuregulin. Consistent with this, the neuregulin receptor components erbB2 and erbB3 are expressed and phosphorylated in developing sciatic nerve. These data suggest that Schwann cell number in developing peripheral nerve is regulated by apoptosis through competition for axonally derived neuregulin.
authors.affiliation: Division of Neurological Research, Children's Hospital of Philadelphia, Pennsylvania 19104, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Grinspan
authors.forename: M A
authors.initials: MA
authors.lastname: Marchionni
authors.forename: M
authors.initials: M
authors.lastname: Reeves
authors.forename: M
authors.initials: M
authors.lastname: Coulaloglou
authors.forename: S S
authors.initials: SS
authors.lastname: Scherer
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000502:physiology; D017209:Apoptosis / Q000187:drug effects; D001369:Axons / Q000502:physiology*; D003714:Denervation; D066246:ErbB Receptors / Q000378:metabolism; D006023:Glycoproteins / Q000494:pharmacology / Q000502:physiology*; D009186:Myelin Sheath / Q000502:physiology; D020880:Neuregulins; D010641:Phenotype; D010766:Phosphorylation; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D020893:Receptor, ErbB-3; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism*; D012583:Schwann Cells / Q000502:physiology*; D012584:Sciatic Nerve / Q000166:cytology / Q000254:growth & development / Q000502:physiology*
chemical_list: D066246:ErbB Receptors; D006023:Glycoproteins; D020880:Neuregulins; D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D020893:Receptor, ErbB-3; D017475:Receptors, Nerve Growth Factor