title: Dosimetric verification of intensity-modulated fields.
abstract: The optimization of intensity distributions and the delivery of intensity-modulated treatments with dynamic multi-leaf collimators (MLC) offer important improvements to three-dimensional conformal radiotherapy. In this study, a nine-beam intensity-modulated prostate plan was generated using the inverse radiotherapy technique. The resulting fluence profiles were converted into dynamic MLC leaf motions as functions of monitor units. The leaf motion pattern data were then transferred to the MLC control computer and were used to guide the motions of the leaves during irradiation. To verify that the dose distribution predicted by the optimization and planning systems was actually delivered, a homogeneous polystyrene phantom was irradiated with each of the nine intensity-modulated beams incident normally on the phantom. For each exposure, a radiographic film was placed normal to the beam in the phantom to record the deposited dose. The films were calibrated and scanned to generate 2-D isodose distributions. The dose was also calculated by convolving the incident fluence pattern with pencil beams. The measured and calculated dose distributions were compared and found to have discrepancies in excess of 5% of the central axis dose. The source of discrepancies was suspected to be the rounded edges of the leaves and the scattered radiation from the various components of the collimation system. After approximate corrections were made for these effects, the agreement between the two dose distributions was within 2%. We also studied the impact of the "tongue-and-groove" effect on dynamic MLC treatments and showed that it is possible to render this effect inconsequential by appropriately synchronizing leaf motions. This study also demonstrated that accurate and rapid delivery of realistic intensity-modulated plans is feasible using a dynamic multi-leaf collimator.
authors.affiliation: Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: S
authors.initials: S
authors.lastname: Spirou
authors.forename: T
authors.initials: T
authors.lastname: LoSasso
authors.forename: J
authors.initials: J
authors.lastname: Stein
authors.forename: C S
authors.initials: CS
authors.lastname: Chui
authors.forename: B
authors.initials: B
authors.lastname: Mohan
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D005069:Evaluation Studies as Topic; D006801:Humans; D008297:Male; D019047:Phantoms, Imaging; D011471:Prostatic Neoplasms / Q000532:radiotherapy; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods* / Q000706:statistics & numerical data