The role of motor activity in diet-induced obesity in C57BL/6J mice.
Previous research in our laboratory has demonstrated that the C57BL/6J (B/6J) mouse has a predisposition to develop severe obesity if placed on a high-fat diet. In the present study we assessed the role of physical activity in this phenomenon. Obesity-prone B/6J and obesity-resistant A/J mice were placed on one of four diets; high fat/high sucrose, high fat/low sucrose, low fat/high sucrose, and low fat/low sucrose. After 4 months, all animals on the high-fat diets had gained more weight than animals on the low-fat diets, and this phenomenon was greatly exaggerated in B/6J mice. Despite the fact that B/6J mice gained more weight than A/J mice on high-fat diets without consuming more calories, spontaneous motor activity was elevated in B/6J mice compared to A/J mice. There was no effect of the diets on activity either within or across strains. These data suggest that predisposition to diet-induced obesity is not explainable by reduced levels of physical activity.
Brownlow
B S
BS
Department of Psychology, Sarah W. Stedman Nutrition Center of Duke University, Durham, NC, USA.
Petro
A
A
Feinglos
M N
MN
Surwit
R S
RS
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage*; D002149:Energy Intake / Q000235:genetics; D007328:Insulin / Q000097:blood; D008297:Male; D051379:Mice; D008805:Mice, Inbred A / Q000235:genetics; D008810:Mice, Inbred C57BL / Q000235:genetics; D008820:Mice, Obese / Q000235:genetics; D009043:Motor Activity / Q000235:genetics* / Q000502:physiology; D009765:Obesity / Q000235:genetics*; D013045:Species Specificity; D015430:Weight Gain / Q000235:genetics
D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin