title: Observations on the transmission of scrapie in experiments using embryo transfer.
abstract: This investigation studied the maternal transmission of scrapie in sheep by using embryo transfer to examine the viability of highly susceptible offspring derived from scrapie-affected and uninfected donors. The study also examined the effect of washing the embryos. Scrapie occurred in both washed and unwashed embryo-derived Sip sAsA progeny from both groups of donor ewes. As a result, the earlier observation that scrapie might pass via the unwashed embryo to develop as disease in adult sheep has to be reassessed. Several other implications of the work are considered, including the possibility that natural scrapie is not purely a genetic disease.
authors.affiliation: Institute for Animal Health, BBSRC and MRC Neuropathogenesis Unit, Edinburgh.
authors.forename: J D
authors.initials: JD
authors.lastname: Foster
authors.forename: N
authors.initials: N
authors.lastname: Hunter
authors.forename: A
authors.initials: A
authors.lastname: Williams
authors.forename: M J
authors.initials: MJ
authors.lastname: Mylne
authors.forename: W A
authors.initials: WA
authors.lastname: McKelvey
authors.forename: J
authors.initials: J
authors.lastname: Hope
authors.forename: H
authors.initials: H
authors.lastname: Fraser
authors.forename: C
authors.initials: C
authors.lastname: Bostock
mesh_terms: D000483:Alleles; D000822:Animal Husbandry / Q000379:methods; D000818:Animals; D015153:Blotting, Western / Q000662:veterinary; D002490:Central Nervous System / Q000737:chemistry; D004624:Embryo Transfer / Q000009:adverse effects / Q000379:methods / Q000662:veterinary*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D008297:Male; D008431:Maternal-Fetal Exchange; D018620:PrPSc Proteins / Q000032:analysis; D011247:Pregnancy; D012608:Scrapie / Q000175:diagnosis / Q000235:genetics / Q000635:transmission*; D012756:Sheep / Q000235:genetics*
chemical_list: D018620:PrPSc Proteins