Antisense oligodeoxynucleotides to c-fos are amnestic for passive avoidance in the chick.
Induction of c-fos occurs in the forebrain when chicks are trained on a passive avoidance task. Suppression of c-Fos protein synthesis with antisense oligodeoxynucleotides prevented long-term memory retention when injected 10-11 h before training, but not if injections were made between 3 h pre-and 3 h post-training. c-fos expression is thus necessary for long-term memory retention, presumably because of its control of induction of the signalling pathway that ultimately results in the protein synthesis subserving synaptic remodelling.
Mileusnic
R
R
Open University, Biology Department, Milton Keynes, UK.
Anokhin
K
K
Rose
S P
SP
D000595:Amino Acid Sequence; D000647:Amnesia / Q000139:chemically induced*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002645:Chickens; D005260:Female; D008297:Male; D008969:Molecular Sequence Data; D016376:Oligonucleotides, Antisense / Q000494:pharmacology*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D012153:Retention, Psychology / Q000187:drug effects*
D016376:Oligonucleotides, Antisense; D016760:Proto-Oncogene Proteins c-fos