title: The effect of skin incision followed by alfentanil on catecholamine levels and on the T-wave amplitude of ECG during isoflurane anaesthesia.
abstract: Haemodynamic, ECG T-wave amplitude and plasma potassium changes and plasma catecholamine responses to skin incision followed by alfentanil were studied in 24 ASA I patients. Propofol and vecuronium were used without anticholinergics for induction of anaesthesia followed by isoflurane in 02/air. End-tidal isoflurane concentration was kept constant (0.7%) for 30 min before the skin incision. Five min after the skin incision alfentanil 30 mu g kg-1 was given. Blood samples for catecholamines and plasma potassium concentrations were drawn from right ventricle of the heart one minute before and after the skin incision and two minutes after alfentanil. Heart rate, systolic and diastolic arterial pressures increased after the skin incision (P < 0.001), and decreased after alfentanil (P < 0.001). Plasma adrenaline and noradrenaline concentrations increased slightly after the skin incision (P < 0.05 and P < 0.01, respectively). Noradrenaline levels continued to increase after alfentanil (P < 0.001) despite totally abolished haemodynamic responses to the skin incision. ECG T-wave amplitude changes, measured as R/T ratio, did not correlate to the changes in plasma catecholamine levels: both rapid increases and decreases in R/T ratio were seen. No plasma potassium changes were seen during the trial. T-wave changes, occurring in seconds after the skin incision, are probably produced by a direct catecholamine release from cardiac sympathetic nerve endings.
authors.affiliation: Medical School, University of Tampere, Finland.
authors.forename: P A
authors.initials: PA
authors.lastname: Annila
authors.forename: L
authors.initials: L
authors.lastname: Lindgren
authors.forename: P
authors.initials: P
authors.lastname: Loula
authors.forename: M
authors.initials: M
authors.lastname: Scheinin
authors.forename: A M
authors.initials: AM
authors.lastname: Yli-Hankala
mesh_terms: D000328:Adult; D015760:Alfentanil; D000704:Analysis of Variance; D000768:Anesthesia, General / Q000706:statistics & numerical data; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D002395:Catecholamines / Q000097:blood*; D062109:Dermatologic Surgical Procedures; D004562:Electrocardiography / Q000187:drug effects* / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007530:Isoflurane; D008297:Male; D008875:Middle Aged; D012815:Signal Processing, Computer-Assisted; D013514:Surgical Procedures, Operative
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D002395:Catecholamines; D015760:Alfentanil; D007530:Isoflurane