title: Participation of the autonomic nervous system in lipolysis induced by intraventricular injection of carbachol in the pigeon.
abstract: The possible involvement of central cholinergic neurotransmission in lipomobilization in avian species was investigated by injecting carbachol into the brain lateral ventricle (i.c.v.) of conscious pigeons (N = 9 per experimental group). I.c.v. injections of carbachol (27 nmol in 1 microliter) induced an intense increase (nearly 91% above baseline levels) in the concentration of plasma free fatty acids (FFA). Previous intraperitoneal administration of hexamethonium (10 mg/kg) completely blocked the lipomobilizing effect of i.c.v. injections of carbachol. These results suggest that cholinergic neurons may be involved in central mechanisms controlling FFA mobilization in pigeons, and that this response is mainly mediated by activation of autonomic nervous system.
authors.affiliation: Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Brazil.
authors.forename: D M
authors.initials: DM
authors.lastname: de Mello
authors.forename: C G
authors.initials: CG
authors.lastname: Freitas
authors.forename: J M
authors.initials: JM
authors.lastname: Neto
authors.forename: M A
authors.initials: MA
authors.lastname: Paschoalini
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology*; D002217:Carbachol / Q000008:administration & dosage / Q000494:pharmacology*; D018679:Cholinergic Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D018680:Cholinergic Antagonists / Q000494:pharmacology; D010856:Columbidae / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D018738:Hexamethonium / Q000494:pharmacology; D007276:Injections, Intraventricular; D008066:Lipolysis / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
chemical_list: D018679:Cholinergic Agonists; D018680:Cholinergic Antagonists; D005230:Fatty Acids, Nonesterified; D018738:Hexamethonium; D002217:Carbachol; D000109:Acetylcholine