title: Localization of the tight junction protein gene TJP1 to human chromosome 15q13, distal to the Prader-Willi/Angelman region, and to mouse chromosome 7.
abstract: The gene encoding the tight junction (zonula occludens) protein, TJP1, was mapped to human chromosome 15q13 by fluorescence in situ hybridization (FISH) using a cDNA probe. The Jackson Laboratory backcross DNA panel derived from the cross (C57BL/6JEi x SPRET/Ei) F1 females x SPRET/Ei males was used to map the mouse Tjp1 to chromosome 7 near position 30 on the Chromosome Committee Map, a region with conserved homology to human chromosome 15q13. FISH studies on metaphases from patients with the Prader-Willi (PWS) or the Angelman syndrome (AS) showed that TJP1 maps close but distal to the PWS/AS chromosome region.
authors.affiliation: Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA.
authors.forename: T K
authors.initials: TK
authors.lastname: Mohandas
authors.forename: X N
authors.initials: XN
authors.lastname: Chen
authors.forename: L B
authors.initials: LB
authors.lastname: Rowe
authors.forename: E H
authors.initials: EH
authors.lastname: Birkenmeier
authors.forename: A S
authors.initials: AS
authors.lastname: Fanning
authors.forename: J M
authors.initials: JM
authors.lastname: Anderson
authors.forename: J R
authors.initials: JR
authors.lastname: Korenberg
mesh_terms: D017204:Angelman Syndrome / Q000235:genetics*; D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D010750:Phosphoproteins / Q000235:genetics*; D011218:Prader-Willi Syndrome / Q000235:genetics*; D062826:Zonula Occludens-1 Protein
chemical_list: D008565:Membrane Proteins; D010750:Phosphoproteins; C569042:TJP1 protein, human; C569043:Tjp1 protein, mouse; D062826:Zonula Occludens-1 Protein