[Low doses of heparin in the prevention of postoperative thrombosis of deep veins of the lower limbs].
As shown by 125I-fibrinogen, in the course of 10-year investigation on low-dose heparin given in low doses (15000 U/day) to prevent postoperative thrombosis in the deep veins of the lower limbs, the investigators succeeded in the reduction of the thrombosis occurrence from 32 to 8%. Out of 3700 surgical patients (age over 40, duration of surgery 1 hour and more) pretreated with anticoagulant only 6 (0.16%) died of pulmonary artery thrombosis. This means that relevant lethality decreased 9-fold compared to controls untreated with prophylactic heparin. Serious hemorrhagic complication due to low-dose heparin were not observed.
Baeshko
A A
AA
Shorokh
G P
GP
D000328:Adult; D000367:Age Factors; D006493:Heparin / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D011183:Postoperative Complications / Q000517:prevention & control*; D013924:Thrombophlebitis / Q000517:prevention & control*
D006493:Heparin