Systemic inflammatory response and the splanchnic bed in cardiopulmonary bypass.
The splanchnic bed undoubtedly undergoes sub-clinical injury in the majority of patients undergoing routine CPB. Dependent upon patient and perfusion factors, this injury may be self-limiting or develop through a cascade of inflammatory mediators into multisystem organ failure. The gut may be damaged by the bioincompatibility of CPB, but it is, as a consequence of hypoperfusion and dysoxia, also a major source of bacterial and nonbacterial inflammatory mediators.
Ohri
S K
SK
Cardiothoracic Unit, Hammersmith Hospital, Royal Postgraduate Medical School, London, UK.
D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D006801:Humans; D000860:Hypoxia / Q000209:etiology; D007249:Inflammation / Q000209:etiology*; D018836:Inflammation Mediators / Q000502:physiology; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism; D011183:Postoperative Complications / Q000209:etiology*; D013152:Splanchnic Circulation
D018836:Inflammation Mediators