Release of 5-fluorouracil from poly(acrylamide-co-monopropyl itaconate) hydrogels.
The aim of this work was to test the application of copolymeric poly(acrylamide-co-monopropyl itaconate) (A-MPI) hydrogels on the release of 5-fluorouracil (5-FU). The equilibrium degree of swelling in saline solution was 83 +/- 2%. 5-FU, as the sodium salt, was trapped in gels by placing it in the polymerization feed mixture. The diffusion coefficients for both swelling of the gels and the release of 5-FU were determined, in addition to the activation energies for both processes. To determine the applicability of these copolymers, A-MPI (75:25) gel was subcutaneously implanted in rats and the drug plasma concentration was determined by HPLC.
Blanco
M D
MD
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Computense de Madrid, Spain.
García
O
O
Olmo
R
R
Teijón
J M
JM
Katime
I
I
D020106:Acrylamide; D000178:Acrylamides / Q000737:chemistry*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004058:Diffusion; D016503:Drug Delivery Systems / Q000379:methods*; D004343:Drug Implants; D005472:Fluorouracil / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics; D005782:Gels; D008297:Male; D011108:Polymers / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013386:Succinates / Q000737:chemistry*; D013696:Temperature; D013997:Time Factors
D000178:Acrylamides; D004343:Drug Implants; D005782:Gels; D011108:Polymers; D013386:Succinates; D020106:Acrylamide; C005229:itaconic acid; D005472:Fluorouracil