title: Alloxan stimulation and subsequent inhibition of insulin release from in situ perfused rat pancreas.
abstract: In the performed experiment the effect of alloxan on insulin secretion by in situ perfused rat pancreas was determined. It was found that alloxan added to the perfusion medium results in a sudden, short-term release of insulin. This effect is independent on the presence of glucose (6.66 mmol/l) in the perfusion medium. Furthermore, it was observed that glucose at 16.66 mmol/l concentration after alloxan perfusion does not stimulate insulin secretion.
authors.affiliation: Department of Animal Physiology and Biochemistry, Academy of Agriculture, Poznań, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Kliber
authors.forename: T
authors.initials: T
authors.lastname: Szkudelski
authors.forename: J
authors.initials: J
authors.lastname: Chichłowska
mesh_terms: D000496:Alloxan / Q000494:pharmacology*; D000818:Animals; D005947:Glucose / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D007328:Insulin; D000496:Alloxan; D005947:Glucose