Molecular genetics and molecular biology advances in brain tumors.
As the genes that regulate cell growth and proliferation are being identified and their encoded proteins characterized, our understanding of the molecular basis of tumor development is expanding rapidly. This review focuses on recent studies examining alterations of growth-regulatory genes in brain tumors, including those involving the inactivation of gene products that normally suppress cell growth (tumor-suppressor genes) or those involving the activation of gene products that promote cell growth (oncogenes) and presents information concerning the molecular biology associated with these changes.
James
C D
CD
Department of Pathology and Laboratory Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
Olson
J J
JJ
D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D002352:Carrier Proteins / Q000096:biosynthesis / Q000235:genetics; D002453:Cell Cycle / Q000235:genetics; D019941:Cyclin-Dependent Kinase Inhibitor p16; D005784:Gene Amplification; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D016158:Genes, p53; D005910:Glioma / Q000235:genetics; D006801:Humans; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics; D009687:Nuclear Proteins; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis / Q000235:genetics; D051736:Proto-Oncogene Proteins c-mdm2; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
D002352:Carrier Proteins; D019941:Cyclin-Dependent Kinase Inhibitor p16; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D016159:Tumor Suppressor Protein p53; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2