Lod score curves for phase-unknown matings.
For a phase-unknown nuclear family, we show that the likelihood and lod score are unimodal, and we describe conditions under which the maximum occurs at recombination fraction theta = 0, theta = 1/2, and 0 < theta < 1/2. These simply stated necessary and sufficient conditions seem to have escaped the notice of previous statistical geneticists.
Hulbert-Shearon
T
T
Department of Biostatistics, University of Michigan, Ann Arbor, USA.
Boehnke
M
M
Lange
K
K
D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008297:Male; D008432:Mathematical Computing; D008957:Models, Genetic; D010375:Pedigree