title: Influence of the level of the transmembrane potential on the dynamics of the extinction of the amplitude of the synaptic reactions of the snail under voltage clamping conditions.
abstract: The influence of the level of the transmembrane potential on the dynamics of the extinction of the amplitudes of summary excitatory postsynaptic currents arising in identified giant parietal neurons in response to rhythmic stimulation of the intestinal nerve was investigated in a preparation of the isolated CNS of the common snail in order to identify the possibility of the participation of the postsynaptic element in synaptic plasticity. It was demonstrated that, at a greater value of the transmembrane potential, the decrease in the amplitudes of the postsynaptic currents which have been induced by rhythmic stimulation takes place more rapidly. It was also demonstrated that at a higher frequency of stimulation of the nerve, the effect of the influence of the membrane potential level on the dynamics of the synaptic reactions is more prominent. The data obtained may be regarded as an argument in favor of the possibility of the participation of the post-synapse in plasticity.
authors.affiliation: Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
authors.forename: P V
authors.initials: PV
authors.lastname: Gusev
mesh_terms: D000818:Animals; D004594:Electrophysiology; D005108:Extinction, Psychological / Q000502:physiology*; D006372:Helix, Snails / Q000502:physiology*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000502:physiology; D009474:Neurons / Q000502:physiology; D018408:Patch-Clamp Techniques; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology