Association study between schizophrenia and monoamine oxidase A and B DNA polymorphisms.
Monoamine oxidases (MAO) A and B, which are encoded by two distinct genes located on the human X chromosome, are both involved in the oxidative metabolism of dopamine. Decreased levels of platelet MAO-B activity has been reported in patients with schizophrenia and genetic variation in MAO activity had been proposed as a significant factor in the etiology of this disease. We carried out an association study using two intragenic polymorphisms within the MAO-A and MAO-B genes in 110 schizophrenic patients and 87 control subjects. For each polymorphic marker, no significant difference in allelic frequencies was observed between patients and controls. Nevertheless, a trend toward an association between allele 1 of the MAO-B gene and paranoid schizophrenia was found. Our results do not support the hypothesis that inherited variants of MAO genes might play a major role in a genetic predisposition to schizophrenia. Since several previous reports found a low MAO-B platelet activity in patients with paranoid schizophrenia, the identification of polymorphisms related to enzyme activity would be useful.
Coron
B
B
Groupe de Recherche sur la Schizophrénie, Université de Rouen, Centre Hospitalier Spécialisé du Rouvray, Sotteville Les Rouen, France.
Campion
D
D
Thibaut
F
F
Dollfus
S
S
Preterre
P
P
Langlois
S
S
Vasse
T
T
Moreau
V
V
Martin
C
C
Charbonnier
F
F
Laurent
C
C
Mallet
J
J
Petit
M
M
Frebourg
T
T
D000293:Adolescent; D000328:Adult; D000483:Alleles; D004247:DNA / Q000235:genetics*; D004298:Dopamine / Q000502:physiology; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000201:enzymology / Q000235:genetics*; D012565:Schizophrenic Psychology
D007527:Isoenzymes; D004247:DNA; D008995:Monoamine Oxidase; D004298:Dopamine