[Cardiorespiratory and analgesic effects of continuous infusion of propofol in swine as experimental animals].
OBJECTIVE
To study the effects of 3 doses of continuous infusion of propofol on heart rate (HR), arterial pressure (AP), cardiac output (CO), pulmonary artery pressure (PAP), pulmonary capillary pressure (PCP), central venous pressure, flow volume, minute volume, arterial gases and analgesic effect.


METHODS
Eighteen Landrace-Large-White pigs were randomly assigned to 3 groups of 6 based on dose of propofol used. An intravenous dose of 2 mg/kg propofol was followed by the continuous infusion corresponding to each group: group I (GI) received 9 mg/kg/h, group II (GII) received 11 mg/kg/h and group III (GIII) received 13 mg/kg/h, each for a period of 1 hour. Variables were recorded 5, 15, 30, 45 and 60 min after the intravenous induction dose. When the infusion was withdrawn, the time elapsing before recovery of sternal decubitus (SDT) position was recorded for each animal.


RESULTS
The following changes from baseline values were statistically significant: AP and PAP increased and PaO2 and MV decreased in GI, with SDT recovery after 27 +/- 4 min; PA increased and FV decreased in GII, while SDT recovery was at 29 +/- 5 min; and diastolic arterial pressure, PCP, CO and HR decreased in GIII. All the pigs in the last group experienced apnea requiring mechanical ventilation and SDT was recovered after 63 +/- 7 min. PCP was significantly higher in GII and GIII than in GI. None of the doses produced an analgesic effect.
Tendillo
F J
FJ
Departamento de Cirugía, Universidad Autónoma de Madrid.
Mascías
A
A
Santos
M
M
de Segura
I A
IA
Castillo-Olivares
J L
JL
D000698:Analgesia; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D000818:Animals; D006439:Hemodynamics / Q000187:drug effects*; D007262:Infusions, Intravenous; D015742:Propofol / Q000008:administration & dosage*; D015656:Respiratory Mechanics / Q000187:drug effects*; D013552:Swine
D018686:Anesthetics, Intravenous; D015742:Propofol