title: Plexiform leiomyoma of the esophagus: a peculiar gross variant simulating plexiform neurofibroma.
abstract: A plexiform variant of leiomyoma of the esophagus in a 51-year-old woman is reported. The patient was diagnosed with a tumor of the esophagus in an X-ray mass survey of the upper gastrointestinal tract. She was referred to the Ryukyu University Hospital for further examination. She appeared healthy with no complaints. Upper gastrointestinal series revealed an oval, well-defined filling defect in the lower esophagus just above the esophagogastric junction. Endoscopy revealed an undulating bulge covered with normal esophageal mucosa. Endoscopic ultrasonography showed a sharply demarcated hypoechoic mural tumor with internal linear pattern, with no evidence of penetration into the surrounding tissue. These findings were evaluated as consistent with a leiomyoma. Removing the tumor by enucleation was easily accomplished. Unexpectedly, on gross inspection, the tumor was a plexiform type, mimicking a plexiform neurofibroma. Light and electron microscopic examination and immunohistochemistry of the tumor tissue confirmed leiomyoma. Since the enucleation of the tumor, the patient has been free of recurrence and symptoms for 1.5 years at the time of this report.
authors.affiliation: First Department of Surgery, Ryukyu University School of Medicine, Okinawa, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Higa
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: O
authors.initials: O
authors.lastname: Tamai
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: T
authors.initials: T
authors.lastname: Kusano
authors.forename: Y
authors.initials: Y
authors.lastname: Muto
authors.forename: M
authors.initials: M
authors.lastname: Kiyuna
authors.forename: T
authors.initials: T
authors.lastname: Toda
mesh_terms: D003937:Diagnosis, Differential; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D004945:Esophagoscopy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007889:Leiomyoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009455:Neurofibroma / Q000175:diagnosis