title: Microbiological N-deoxygenation and C-oxygenation of pioglitazone-N-oxide in a single fermentation.
abstract: Oxygenation of pioglitazone-N-oxide by a microorganism isolated from soil was accompanied by N-deoxygenation to produce the pioglitazone metabolites 5-[4-[2-[5-(1-hydroxyethyl)-2-pyridyl]ethoxy]benzyl]-2,4-thiazolidinedio ne and 5-[4-[2-(5-acetyl-2-pyridyl)ethoxy]benzyl]2,4-thiazolidinedione. The oxygenating/deoxygenating organism has been characterized as Streptomyces hygroscopicus strain 02179 (UC 11099). The culture has been deposited with Agricultural Research Service, USDA, with accession number NRRL 18975.
authors.affiliation: Research Laboratories, Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 49001, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Johnson
authors.forename: V P
authors.initials: VP
authors.lastname: Marshall
authors.forename: G P
authors.initials: GP
authors.lastname: Li
authors.forename: J C
authors.initials: JC
authors.lastname: Sih
authors.forename: J I
authors.initials: JI
authors.lastname: Cialdella
authors.forename: W F
authors.initials: WF
authors.lastname: Liggett
authors.forename: E G
authors.initials: EG
authors.lastname: Nidy
mesh_terms: D005285:Fermentation; D007004:Hypoglycemic Agents / Q000378:metabolism*; D000077205:Pioglitazone; D013302:Streptomyces / Q000378:metabolism*; D013844:Thiazoles / Q000378:metabolism*; D045162:Thiazolidinediones
chemical_list: D007004:Hypoglycemic Agents; D013844:Thiazoles; D045162:Thiazolidinediones; D000077205:Pioglitazone