title: Midazolam co-induction and laryngeal mask insertion.
abstract: We have studied the effect of alfentanil and midazolam+alfentanil on the conditions for laryngeal mask airway insertion in patients receiving propofol for induction of anaesthesia. Ninety unpremedicated. ASA 1 or 2 adult patients were randomly allocated to one of three groups: group P received propofol only (2.5 mg.kg-1); group PA received alfentanil (10 micrograms.kg-1) followed by propofol (1.25 mg.kg-1); group PMA received midazolam (0.04 mg.kg-1) and alfentanil (10 micrograms.kg-1) followed by propofol (1.25 mg.kg-1). Further boluses of propofol (0.25 mg.kg-1 every 15 s) were given if the initial dose was inadequate for induction of anaesthesia. Patients in the midazolam+alfentanil group required less propofol (p < 0.001), had better mouth opening (p < 0.001) and fewer undesired responses to laryngeal mask airway insertion (p < 0.001) than the other two groups.
authors.affiliation: Department of Anaesthesia, Ipswich Hospital, Suffolk.
authors.forename: I K
authors.initials: IK
authors.lastname: Driver
authors.forename: S
authors.initials: S
authors.lastname: Wiltshire
authors.forename: P
authors.initials: P
authors.lastname: Mills
authors.forename: N
authors.initials: N
authors.lastname: Lillywhite
authors.forename: R
authors.initials: R
authors.lastname: Howard-Griffin
mesh_terms: D000328:Adult; D015760:Alfentanil / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D017214:Laryngeal Masks; D008874:Midazolam / Q000008:administration & dosage*; D015742:Propofol / Q000008:administration & dosage
chemical_list: D006993:Hypnotics and Sedatives; D015760:Alfentanil; D008874:Midazolam; D015742:Propofol