Hepatic lobar atrophy: association with ipsilateral portal vein obstruction.
OBJECTIVE
This study was performed to evaluate the association between hepatic lobar atrophy, bile duct obstruction, and portal vein obstruction.


METHODS
Thirty cases of hepatic lobar atrophy identified on angiography with CT during arterial portography from August 1992 to March 1995 were retrospectively reviewed by two independent observers. Cases were evaluated for vascular patency and bile duct obstruction. Malignant diagnoses were present in 28 of 30 patients.


RESULTS
Twenty-two patients (73%) had atrophy in the left lobe and eight patients (27%) had right lobar atrophy. Portal vein obstruction was unilateral and confined to the atrophic lobe in 26 patients (87%). In contrast, bile duct obstruction was bilateral in 23 patients (77%) and in only four patients (13%) was it isolated to the atrophic lobe. The correlation between atrophy and portal vein obstruction was significant, with 90% sensitivity, 97% specificity, and 96% positive predictive value (p < .00001). For the correlation between atrophy and biliary obstruction, the sensitivity of angiography with CT during arterial portography was 90%, specificity was 23%, and positive predictive value was 54% (p = .17).


CONCLUSIONS
Hepatic lobar atrophy usually occurs in the setting of combined biliary and portal vein obstruction. A significant correlation exists between hepatic lobar atrophy and ipsilateral portal vein obstruction.
Hann
L E
LE
Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Getrajdman
G I
GI
Brown
K T
KT
Bach
A M
AM
Teitcher
J B
JB
Fong
Y
Y
Blumgart
L H
LH
D000328:Adult; D000368:Aged; D000792:Angiography; D001284:Atrophy; D002779:Cholestasis / Q000150:complications; D003251:Constriction, Pathologic; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications; D011169:Portal Vein / Q000000981:diagnostic imaging / Q000473:pathology*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed