Normalization of immune response and phosphoinositide fatty acid composition of peripheral blood lymphocytes in an alcoholic patient after alcohol abstinence.
After 10 months of alcohol abstinence a malnourished alcoholic patient improved his nutritional status. The analysis of peripheral blood lymphocyte response to mitogenic stimulation with the antibody anti-CD3 and of the fatty acid composition of the (poly)-phosphoinositide fraction derived from lymphocytes revealed: 1) a similar [3H]-thymidine uptake as in control (non-drinker) subjects; 2) a similar relative molar content of the main fatty acids in the (poly)-phosphoinositides as in control subjects. Alcohol abstinence can normalize both the parameters, which are greatly altered during alcohol abuse. This suggests a link between nutritional status and lymphocyte responsiveness via phosphoinositide fatty acid composition.
Stefanini
G F
GF
Istituto di Patologia Medica I, Università di Bologna, Policlinico S. Orsola, Italy.
Castelli
E
E
Foschi
F G
FG
Marsigli
L
L
Addolorato
G
G
Celadon
M
M
Biagi
P L
PL
Bordoni
A
A
Gasbarrini
G
G
Hrelia
S
S
D000437:Alcoholism / Q000097:blood / Q000276:immunology; D017252:CD3 Complex; D002478:Cells, Cultured; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013695:Temperance
D017252:CD3 Complex; D005227:Fatty Acids