Age-associated changes in detrusor sensory function in women with lower urinary tract symptoms.
This study examined changes in bladder sensation which occur with age in women. 1381 women (age range 20-95 years, mean 54.9) with symptoms of lower urinary tract dysfunction underwent urodynamic study. The bladder capacity at which they first became aware of the desire to void was taken as a quantitative measure of bladder sensation. Maximum bladder capacity fell in the eighth and ninth decades (H = 95.84, df = 7, P = 0.00), but by contrast bladder capacity at first desire to void rose progressively in association with age, both in the group as a whole (H = 17.13, df = 7, P = 0.017) and in a subgroup with detrusor instability (n = 952, H = 15.42, df = 7, P = 0.032). This rise in capacity points to a decrease in bladder sensation in association with age. This is not due to neurological disease, anti-muscarinic drugs or oestrogens, as the median capacity at first desire to void of these three subgroups did not differ significantly from that of the group as a whole.
Collas
D M
DM
Department of Medicine, University College London Medical School, St. Pancras Hospital, UK.
Malone-Lee
J G
JG
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D004967:Estrogens / Q000009:adverse effects; D005260:Female; D006801:Humans; D008875:Middle Aged; D009475:Neurons, Afferent / Q000502:physiology; D010275:Parasympathetic Nervous System / Q000502:physiology*; D012677:Sensation / Q000187:drug effects / Q000502:physiology*; D001743:Urinary Bladder / Q000294:innervation* / Q000503:physiopathology; D014555:Urination Disorders / Q000209:etiology / Q000503:physiopathology*; D014563:Urodynamics
D004967:Estrogens