[The action of lactoperoxidase, lactoferrin and lactoglobulin on Shigella sonnei in an in-vivo experiment].
The synergism of the protective action of lactoperoxidase, lactoferrin and lactoglobulin obtained from cow milk, as well as lactoferrin obtained from human milk, was shown in experiments on white mice, infected intranasally with S. sonnei and used as an experimental model. The combined administration of these preparations in doses, each one having no protective action, contributed to the elimination of the bacteria from the lungs and prevented the death of the animals. This phenomenon was found to be nonspecific and suitable for use in the development of preparations for passive immunization against a wide spectrum of microorganisms.
Denisova
I I
II
Pasteur Research Institute of Epidemiology and Microbiology, St.-Petersburg, Russia.
Gennad'eva
T Ia
TIa
Zhdanova
T V
TV
Khristova
M
M
Khazenson
L B
LB
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004405:Dysentery, Bacillary / Q000188:drug therapy* / Q000382:microbiology; D007781:Lactoferrin / Q000627:therapeutic use*; D007782:Lactoglobulins / Q000627:therapeutic use*; D007784:Lactoperoxidase / Q000627:therapeutic use*; D008168:Lung / Q000382:microbiology; D051379:Mice; D012764:Shigella sonnei / Q000302:isolation & purification; D013997:Time Factors
D000900:Anti-Bacterial Agents; D007782:Lactoglobulins; D007784:Lactoperoxidase; D007781:Lactoferrin