Influence of smoking in the glutathione-S-transferase M1 deficiency--associated risk for squamous cell carcinoma of the bladder in schistosomiasis patients in Egypt.
In this study we show an effect of the glutathione-S-transferase M1 (GSTM1) null phenotype on the risk for squamous cell carcinoma (SCC) of the bladder among male smokers in Egypt, with an adjusted odds ratio of 4.8 (95% confidence interval: 1.06-21.77). However, no overall effect of the GSTM1 null phenotype on the risk for bladder SCC was observed.
Lafuente
A
A
Institut de Salut Pública, University of Barcelona, Spain.
Zakahary
M M
MM
el-Aziz
M A
MA
Ascaso
C
C
Lafuente
M J
MJ
Trias
M
M
Carretero
P
P
D000328:Adult; D000367:Age Factors; D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D016009:Chi-Square Distribution; D004198:Disease Susceptibility; D004534:Egypt / Q000453:epidemiology; D005260:Female; D005982:Glutathione Transferase / Q000172:deficiency* / Q000235:genetics; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D012307:Risk Factors; D012552:Schistosomiasis / Q000150:complications* / Q000473:pathology; D012907:Smoking / Q000009:adverse effects*; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology / Q000209:etiology*
D005982:Glutathione Transferase