Degenerative brain disease.
Inherited degenerative diseases of the brain are chronically progressive and often lead to severe debilitation. The cerebellum is particularly susceptible to degenerative processes. For lysosomal storage disorders, the metabolic defect is often known and diagnostic tests are available. For other abiotrophies, the inborn error of metabolism is not known and diagnosis is made on postmortem. Pathogenesis of brain dysfunction is not well understood in a majority of the neurodegenerative diseases.
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Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, Indiana, USA.
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