title: [An experimental study of the immunogenic and protective properties of Coxiella burnetii strain M-44 and a live enteral vaccine against Q fever].
abstract: High effectiveness of C.burnetii strain M-44 was confirmed in experimental studies on subcutaneously immunized guinea pigs ¿correction of pig] after their intratracheal infection with the virulent culture of the infective agent. The study revealed that the dose necessary for the enteral immunization of guinea pigs and monkeys was 10(4.8) -- 10(5.0) times less than that needed for the oral immunization of the animals. Live enteral vaccine obtained on the basis of this strain possessed sufficiently pronounced immunogenic and protective properties, protecting 75% of immunized monkeys from subcutaneous infection with C.burnetii virulent culture.
authors.affiliation: Virological Center of the Research Institute of Microbiology, Sergiev Posad, Moscow Region, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Mikhaĭlov
authors.forename: A A
authors.initials: AA
authors.lastname: Vorob'ev
authors.forename: A A
authors.initials: AA
authors.lastname: Makhlaĭ
authors.forename: G G
authors.initials: GG
authors.lastname: Khaltaeva
authors.forename: T A
authors.initials: TA
authors.lastname: Suvorova
authors.forename: V P
authors.initials: VP
authors.lastname: Krasnianskiĭ
authors.forename: E A
authors.initials: EA
authors.lastname: Iakovlev
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Pashanin
authors.forename: G A
authors.initials: GA
authors.lastname: Dykanov
authors.forename: V N
authors.initials: VN
authors.lastname: Podkuĭko
authors.forename: E V
authors.initials: EV
authors.lastname: Lebedinskaia
mesh_terms: D000818:Animals; D016997:Coxiella burnetii / Q000276:immunology* / Q000472:pathogenicity; D004306:Dose-Response Relationship, Immunologic; D006168:Guinea Pigs; D007114:Immunization / Q000379:methods; D008252:Macaca fascicularis; D010215:Papio; D011778:Q Fever / Q000276:immunology / Q000517:prevention & control*; D051381:Rats; D012290:Rickettsial Vaccines / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000276:immunology; D014774:Virulence
chemical_list: D012290:Rickettsial Vaccines; D014613:Vaccines, Attenuated