title: Neonatal MSG reduces hypothalamic DA, beta-endorphin, and delays weight gain in genetically obese (A viable yellow/alpha) mice.
abstract: Neonatal treatment with monosodium glutamate (MSG) decreases proopiomelanocortin (POMC) peptides and results in obesity. The yellow mouse is a model of obesity induced by the viable yellow (Avy) gene at the agouti locus on Chromosome 2, which results in overproduction of a POMC receptor antagonist. Thus we hypothesized that MSG, when imposed on the genetically susceptible model, would alter the development of obesity. Both yellow obese (Avy) and black lean (alpha/alpha) males were injected on Postnatal Days 1, 3, 5, 7, and 9 with 2.0 mg/g body weight MSG or saline SC. Their food intake, growth parameters, and neurochemical status were examined. Paradoxically, MSG interacted with the yellow phenotype to delay the rapid rate of weight gain characteristic of this model (p < 0.05). Food intake was decreased (p < 0.05) in both phenotypes treated with MSG, as was hypothalamic content of dopamine (p < 0.05) and of the POMC peptide, beta-endorphin (p < 0.001). The yellow obese phenotype was more sensitive than the black lean phenotype to the neurochemical effect of early postnatal MSG administration. Recent reports suggest the agouti locus protein is an antagonist of the receptor for another POMC peptide, melanocyte-stimulating hormone (MSH). Therefore, the balance of functional activity between various POMC peptides appears to be an important factor in the development of both acquired and genetic obesity.
authors.affiliation: Division of Neurotoxicology, National Center for Toxicological Research/USFDA, Jefferson, AR 72079, USA.
authors.forename: F A
authors.initials: FA
authors.lastname: Caputo
authors.forename: S F
authors.initials: SF
authors.lastname: Ali
authors.forename: G L
authors.initials: GL
authors.lastname: Wolff
authors.forename: A C
authors.initials: AC
authors.lastname: Scallet
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D003864:Depression, Chemical; D004298:Dopamine / Q000378:metabolism*; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D006200:Hair Color / Q000187:drug effects; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D008805:Mice, Inbred A; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000235:genetics* / Q000517:prevention & control*; D009929:Organ Size / Q000187:drug effects; D010641:Phenotype; D011333:Pro-Opiomelanocortin / Q000378:metabolism; D051381:Rats; D012970:Sodium Glutamate / Q000494:pharmacology*; D015430:Weight Gain / Q000187:drug effects*; D001615:beta-Endorphin / Q000378:metabolism*
chemical_list: D001615:beta-Endorphin; D011333:Pro-Opiomelanocortin; D004298:Dopamine; D012970:Sodium Glutamate