Farnesyl transferase inhibitors: the successes and surprises of a new class of potential cancer chemotherapeutics.
Proteins that transmit abnormal growth signals offer enticing points of intervention for the treatment of cancer. The discovery that isoprenoid attachment is required for the aberrant biological activity of oncogenic Ras proteins has provided just such a target.
Buss
J E
JE
Department of Biochemistry and Biophysics, Iowa State University, Ames 50011, USA. jbuss@iastate.edu
Marsters
J C
JC
D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors* / Q000235:genetics; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D011905:Genes, ras / Q000235:genetics; D009374:Neoplasms, Experimental / Q000235:genetics; D051381:Rats
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D019883:Alkyl and Aryl Transferases; C064911:p21(ras) farnesyl-protein transferase