Induction of macrophage antiprotozoal activity by monocyte chemotactic and activating factor.
To determine if monocyte chemotactic and activating factor (MCAF) induces intracellular antimicrobial activity, human monocyte-derived macrophages were treated with MCAF and challenged with Toxoplasma gondii and Leishmania donovani. Pretreatment with MCAF induced macrophages to inhibit protozoal replication by approximately 50%. These findings suggest a potential host defense role for MCAF in the inflammatory response to intracellular pathogens.
Mannheimer
S B
SB
Division of Infectious Diseases, Cornell University Medical College, New York, NY 10021, USA.
Hariprashad
J
J
Stoeckle
M Y
MY
Murray
H W
HW
D000818:Animals; D018932:Chemokine CCL2 / Q000494:pharmacology*; D006801:Humans; D007893:Leishmania donovani / Q000187:drug effects* / Q000254:growth & development; D007896:Leishmaniasis / Q000517:prevention & control*; D008264:Macrophages / Q000469:parasitology*; D014122:Toxoplasma / Q000187:drug effects* / Q000254:growth & development; D014123:Toxoplasmosis / Q000517:prevention & control*
D018932:Chemokine CCL2