[Nitroxyl radical Tempol as a modulator of toxic and antineoplastic effect of 6-mercaptopurine].
Both intact mice and those with transplantable adenocarcinoma 755 were used in the investigation. The nitroxyl radical Tempol was shown to cut down the toxicity of 6-mercaptopurine and potentiate its antitumor effect to a certain degree. The study results suggest on the basis of an investigation of cytochrome P450 and some other evidence that said effect of Tempol might be due, at least, in part to antioxidant activity.
Konovalova
N P
NP
D'iachkovskaia
R F
RF
Volkova
L M
LM
Varfolomeev
V N
VN
D000230:Adenocarcinoma / Q000188:drug therapy*; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use* / Q000633:toxicity*; D000970:Antineoplastic Agents / Q000037:antagonists & inhibitors* / Q000633:toxicity; D000975:Antioxidants / Q000494:pharmacology*; D003497:Cyclic N-Oxides / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004357:Drug Synergism; D008297:Male; D015122:Mercaptopurine / Q000037:antagonists & inhibitors* / Q000627:therapeutic use* / Q000633:toxicity; D051379:Mice; D008810:Mice, Inbred C57BL; D013113:Spin Labels; D016019:Survival Analysis
D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D000975:Antioxidants; D003497:Cyclic N-Oxides; D013113:Spin Labels; D015122:Mercaptopurine; C001803:tempol