Renal and spermatozoal toxicity of alpha-bromohydrin, 3-bromolactate and 3-bromopyruvate.
(R,S)- and (R)-3-Bromopropan-1,2-diol (alpha-bromohydrin) produced diuresis and glucosuria when administered to male rats but had no effect on the metabolic activity of rat kidney tubules in vitro. The oxidation products (R,S)-3-bromolactate and 3-bromopyruvate produced brief phases of diuresis but not glucosuria, and severely inhibited the metabolic activity of rat kidney tubules in vitro. alpha-Bromohydrin had no effect on the metabolic activity of boar spermatozoa whereas the oxidation products severely affected mitochondrial metabolism. 3-Bromopyruvate also inhibited boar spermatozoal glyceraldehyde 3-phosphate dehydrogenase.
Jones
A R
AR
Department of Biochemistry, University of Sydney, NSW, Australia.
Porter
K E
KE
Dobbie
M S
MS
D000818:Animals; D004791:Enzyme Inhibitors / Q000633:toxicity*; D006029:Glycosuria / Q000139:chemically induced; D066298:In Vitro Techniques; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D007684:Kidney Tubules / Q000187:drug effects / Q000473:pathology; D007773:Lactates / Q000633:toxicity*; D008297:Male; D011409:Propylene Glycols / Q000633:toxicity*; D011768:Pyruvate Dehydrogenase Complex / Q000037:antagonists & inhibitors*; D011773:Pyruvates / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013089:Spermatocidal Agents / Q000633:toxicity*; D013094:Spermatozoa / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D013552:Swine
D004791:Enzyme Inhibitors; D007773:Lactates; D011409:Propylene Glycols; D011768:Pyruvate Dehydrogenase Complex; D011773:Pyruvates; D013089:Spermatocidal Agents; C043352:3-bromolactic acid; C006818:alpha-bromohydrin; C017092:bromopyruvate