title: Prenatal diagnosis in Treacher Collins syndrome using combined linkage analysis and ultrasound imaging.
abstract: Treacher Collins syndrome is an autosomal dominant disorder of facial development, the features of which include conductive hearing loss and cleft palate. In the current investigation, linkage analysis has been used to make first trimester diagnostic predictions in a pregnancy at high risk of producing an affected child. The results of this analysis predicted that the child would be affected. As predictions of the severity of the disease were not possible, the pregnancy was also assessed by ultrasound imaging. This confirmed the affected diagnosis and predicted that the child would be severely affected.
authors.affiliation: School of Biological Stlences, University of Manchester, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Edwards
authors.forename: A
authors.initials: A
authors.lastname: Fowlie
authors.forename: M P
authors.initials: MP
authors.lastname: Cust
authors.forename: D T
authors.initials: DT
authors.lastname: Liu
authors.forename: I D
authors.initials: ID
authors.lastname: Young
authors.forename: M J
authors.initials: MJ
authors.lastname: Dixon
mesh_terms: D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005799:Genes, Dominant / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008342:Mandibulofacial Dysostosis / Q000175:diagnosis / Q000235:genetics*; D010375:Pedigree; D011296:Prenatal Diagnosis; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics; D014178:Translocation, Genetic / Q000235:genetics; D014463:Ultrasonography
chemical_list: D005819:Genetic Markers