title: Sequential occurrence of hepatocellular carcinoma following Waldenström's macroglobulinemia: the pathogenetic role of chronic liver disease.
abstract: We report a case of sequential occurrence of hepatocellular carcinoma (HCC) following Waldenström's macroglobulinemia (WM) in the course of chronic liver disease. The diagnosis of WM was made in a 55-year-old man with a history of alcohol abuse. He developed HCC in the course of WM, and hepatitis C virus (HCV) infection was detected by enzyme-linked immunosorbent assay. Recent reports suggest that persistent HCV infection is related to the pathogenesis of B cell malignancy. Chronic liver disease may be associated with the pathogenesis of the double malignancies in the present case.
authors.affiliation: Department of Medicine, Jichi Medical School, Tochigi.
authors.forename: T
authors.initials: T
authors.lastname: Izumi
authors.forename: R
authors.initials: R
authors.lastname: Sasaki
authors.forename: S
authors.initials: S
authors.lastname: Tsunoda
authors.forename: M
authors.initials: M
authors.lastname: Hatakeyama
authors.forename: H
authors.initials: H
authors.lastname: Koyama
authors.forename: N
authors.initials: N
authors.lastname: Shinohara
authors.forename: Y
authors.initials: Y
authors.lastname: Miura
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000209:etiology*; D017809:Fatal Outcome; D006526:Hepatitis C / Q000097:blood / Q000150:complications*; D006521:Hepatitis, Chronic / Q000097:blood / Q000150:complications*; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000097:blood / Q000150:complications*; D008113:Liver Neoplasms / Q000097:blood / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D008258:Waldenstrom Macroglobulinemia / Q000097:blood / Q000209:etiology*