Platelet activating factor antagonism improves cardiovascular function in non-hypotensive sepsis in pigs.
OBJECTIVE
To study the effects of platelet activating factor (PAF) antagonism on cardiovascular function in Escherichia coli endotoxaemia in non-hypotensive anaesthetised pigs.


METHODS
Experimental study.


METHODS
Trauma research unit, Sweden.


METHODS
24 Domestic juvenile pigs.


METHODS
18 Pigs received a continuous infusion of E coli endotoxin in a dose of 36 micrograms/kg/hour for 5 hours. They were allocated to two groups of 9 each. The first group (BB-882 group) received a continuous infusion of BB-882 (a novel potent PAF antagonist) 33 mg/kg/hour 30 minutes before the endotoxin while the second group (placebo group) received vehicle alone. Another 6 pigs (control group) received only BB-882.


METHODS
Blood temperature, rigors, heart rate, intravascular pressure, cardiac and stroke volume indices and systemic vascular resistance.


RESULTS
Animals in the BB-882 group had significantly fewer rigors (p < 0.001) and episodes of tachycardia (p < 0.001) than the placebo group. BB-882 significantly reduced the endotoxin-induced systemic hypertension (p < 0.001) and the rise in systemic vascular resistance (p < 0.001). BB-882 group had significantly higher central venous pressure (p < 0.05), pulmonary capillary wedge pressure (p < 0.001), cardiac index (p < 0.02), and stroke volume index (p < 0.001).


CONCLUSIONS
Pretreatment with a potent PAF receptor antagonist improved the cardiovascular function during non-hypotensive E coli endotoxaemia in pigs.
Abu-Zidan
F M
FM
Department of Surgery, University Hospital, Linköping, Sweden.
Walther
S
S
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D019446:Endotoxemia / Q000503:physiopathology; D004927:Escherichia coli Infections / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007930:Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D018805:Sepsis / Q000503:physiopathology*; D013318:Stroke Volume / Q000187:drug effects; D013552:Swine
C094498:BB 882; D010972:Platelet Activating Factor; D007930:Leucine