Autoimmune myocarditis.
We have developed two models of myocarditis in mice. The first is produced by infection with Coxsackievirus B3; the second results from immunization with cardiac myosin. Both forms of myocarditis occur in the same genetically predisposed strains. Genetically resistant mice can be rendered susceptible to myocarditis by co-treatment with cytokines IL-1 or TNF. Moreover, the disease is inhibited by administration of an antagonist of IL-1. These models will be useful for clarifying outstanding issues related to human myocarditis or dilated cardiomyopathy.
Rose
N R
NR
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA.
Hill
S L
SL
D000818:Animals; D015551:Autoimmunity; D004195:Disease Models, Animal; D029822:Enterovirus B, Human / Q000737:chemistry*; D051379:Mice; D009205:Myocarditis / Q000209:etiology / Q000503:physiopathology; D009218:Myosins / Q000008:administration & dosage / Q000276:immunology*
D009218:Myosins