Colocalization of GABA and glycine in the rat dorsal column nuclei.
About half the neurons in the rat dorsal column nuclei were immunopositive for glycine or for GABA; these were smaller than immunonegative neurons. In double-stained material, 29% of stained neurons were immunopositive for GABA only, and 42% for both antigens. The results resemble those reported for spinal cord laminae that receive fast-conducting primary afferents, and suggest that glycine is an inhibitory neurotransmitter in the dorsal column nuclei.
Popratiloff
A
A
Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill 27599, USA.
Valtschanoff
J G
JG
Rustioni
A
A
Weinberg
R J
RJ
D000818:Animals; D005998:Glycine / Q000032:analysis*; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000737:chemistry* / Q000166:cytology; D005680:gamma-Aminobutyric Acid / Q000032:analysis*
D005680:gamma-Aminobutyric Acid; D005998:Glycine