title: Changes in forebrain serotonin at the light-dark transition: correlation with behaviour.
abstract: In vivo microdialysis in the rat was used to determine whether changes in forebrain serotonin (5-HT) levels seen during the light-dark transition differ by area examined and whether these changes could be accounted for by complementary changes in behaviour. 5-HT levels increased significantly during the first half hour of dark phase in the hippocampus (45.9%), striatum (13.4%), amygdala (19.7%) and prefrontal cortex (18.4%), the increase in the hippocampus being significantly larger than those in the other areas. 5-HT levels co-varied significantly with changes in the levels of alert waking, a behavioural measure of the time spent in active waking, suggesting that this factor might account for the changes in 5-HT across the light-dark transition.
authors.affiliation: Program in Neuroscience, Princeton University, NJ 08544-1010, USA.
authors.forename: L E
authors.initials: LE
authors.lastname: Rueter
authors.forename: B L
authors.initials: BL
authors.lastname: Jacobs
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001143:Arousal / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D003624:Darkness; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008027:Light; D008297:Male; D017551:Microdialysis; D009474:Neurons / Q000502:physiology; D016548:Prosencephalon / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism*; D012890:Sleep / Q000502:physiology; D014851:Wakefulness / Q000502:physiology
chemical_list: D012701:Serotonin; D006897:Hydroxyindoleacetic Acid