title: Oral mucosal desquamation of pre- and post-menopausal women. A comparison of response to sodium lauryl sulphate in toothpastes.
abstract: The aim of the present study was to investigate whether a difference in susceptibility to chemically induced irritation of the oral mucosa in 14 pre- and 14 post-menopausal women exists, following local exposure to sodium lauryl sulphate (SLS) in toothpastes. 4 different pastes differing only in detergent concentration present, or not, were used. The participants applied 1 cm of the different test toothpastes to a cap splint covering the teeth and the oral mucosa of the upper jaw 2 x daily for 2 min during a period of 4 days. 42 desquamative reactions of the oral mucosa (in 20 subjects) were observed, 29 and 13 in the pre- and the post-menopausal group, respectively. Desquamation was only experienced following exposure to SLS-containing toothpastes, not succeeding SLS-free paste. The results demonstrated that oral mucosa of pre-menopausal women was significantly more sensitive to SLS than oral mucosa of post-menopausal women. The difference in mucosal irritation between the 2 groups increased with increasing concentration of SLS.
authors.affiliation: Department of Oral Surgery and Oral Medicine, Dental Faculty, University of Oslo, Norway.
authors.forename: B B
authors.initials: BB
authors.lastname: Herlofson
authors.forename: P
authors.initials: P
authors.lastname: Barkvoll
mesh_terms: D000328:Adult; D000368:Aged; D003902:Detergents / Q000009:adverse effects* / Q000032:analysis; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D007509:Irritants / Q000009:adverse effects / Q000032:analysis; D008875:Middle Aged; D017698:Postmenopause; D017697:Premenopause; D012044:Regression Analysis; D012907:Smoking / Q000009:adverse effects; D012967:Sodium Dodecyl Sulfate / Q000009:adverse effects* / Q000032:analysis; D013280:Stomatitis / Q000139:chemically induced*; D013501:Surface-Active Agents / Q000009:adverse effects* / Q000032:analysis; D014100:Toothpastes / Q000009:adverse effects* / Q000032:analysis
chemical_list: D003902:Detergents; D007509:Irritants; D013501:Surface-Active Agents; D014100:Toothpastes; D012967:Sodium Dodecyl Sulfate