title: Differential distribution of adenosine A2 receptors in the epididymal and prostatic portions of the rat vas deferens.
abstract: In the rat vas deferens there are prejunctional A1 receptors mediating inhibition of transmitter release and post-junctional A1 and A2 receptors mediating enhancement and inhibition of contractions respectively. In this study the distribution of adenosine receptors in the prostatic and epididymal portions of the bisected rat vas deferens was investigated. The pre- and post-junctional A1 receptors were present on both portions of the bisected tissue. However, post-junctional A2 receptors appear to be present only in the prostatic region, showing that adenosine receptors are differentially distributed along the length of the rat vas deferens.
authors.affiliation: Receptors and Cellular Regulation Research Group, School of Biological Sciences, University of Surrey, Guildford, UK.
authors.forename: V R
authors.initials: VR
authors.lastname: Brownhill
authors.forename: S M
authors.initials: SM
authors.lastname: Hourani
authors.forename: I
authors.initials: I
authors.lastname: Kitchen
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D019830:Adenosine-5'-(N-ethylcarboxamide); D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018047:Receptors, Purinergic P1 / Q000187:drug effects / Q000378:metabolism*; D014649:Vas Deferens / Q000187:drug effects / Q000378:metabolism*; D014970:Xanthines / Q000494:pharmacology
chemical_list: D018047:Receptors, Purinergic P1; D014970:Xanthines; D019830:Adenosine-5'-(N-ethylcarboxamide); C048599:N(6)-cyclopentyladenosine; C051360:1,3-dipropyl-8-cyclopentylxanthine; D000241:Adenosine