title: Chemical and biological approaches to glycoprotein synthesis.
abstract: Protein glycosylation is a common posttranslational modification that produces glycoproteins that are highly complex in terms of both their structure and in their function. Systematic structure-function studies of such glycoproteins require synthetic methods that can produce homogeneous glycoproteins with defined oligosaccharide sidechains.
authors.affiliation: Department of Chemistry, The University of Michigan, Ann Arbor, MI 48109-1055, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Bill
authors.forename: S L
authors.initials: SL
authors.lastname: Flitsch
mesh_terms: D006023:Glycoproteins / Q000096:biosynthesis* / Q000138:chemical synthesis / Q000378:metabolism; D006031:Glycosylation; D009844:Oligosaccharides / Q000378:metabolism*
chemical_list: D006023:Glycoproteins; D009844:Oligosaccharides