Linking the metabolism of hydroquinone to its nephrotoxicity and nephrocarcinogenicity.
Lau
S S
SS
Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, 78712, USA.
Peters
M M
MM
Kleiner
H E
HE
Canales
P L
PL
Monks
T J
TJ
D000818:Animals; D002273:Carcinogens / Q000378:metabolism* / Q000633:toxicity*; D002417:Cattle; D016923:Cell Death / Q000187:drug effects; D004247:DNA / Q000737:chemistry / Q000187:drug effects; D004249:DNA Damage; D006873:Hydroquinones / Q000378:metabolism* / Q000633:toxicity*; D006965:Hyperplasia / Q000139:chemically induced / Q000473:pathology; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D017382:Reactive Oxygen Species / Q000378:metabolism
D002273:Carcinogens; D006873:Hydroquinones; D017382:Reactive Oxygen Species; D004247:DNA; C031927:hydroquinone