title: Targets of glass regulation in the Drosophila eye disc.
abstract: The Drosophila glass gene is required for the differentiation and survival of photoreceptors in the compound eye, ocelli and larval photoreceptor organ, glass encodes a zinc finger protein which can activate transcription in cell culture and is likely to act by regulating the expression of other genes. We have shown that it directly or indirectly controls the expression of approximately 25% of all enhancer trap lines expressed in the eye disc. glass gene activity is required to activate 19% of the lines, some of which express beta-galactosidase in photoreceptor subtype-specific patterns, and to repress 6%. The phenotype of eye discs doubly mutant for glass and the homeobox gene rough suggests that glass is required for subtype specification and for recruitment of cells to the ommatidial cluster.
authors.affiliation: MCB and HHMI, UC Berkeley, CA 94720, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Treisman
authors.forename: G M
authors.initials: GM
authors.lastname: Rubin
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins / Q000502:physiology*; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000196:embryology* / Q000235:genetics; D047108:Embryonic Development; D004742:Enhancer Elements, Genetic; D005123:Eye / Q000196:embryology*; D018507:Gene Expression Regulation, Developmental; D008869:Microtubule-Associated Proteins; D010641:Phenotype; D010786:Photoreceptor Cells / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology
chemical_list: D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D008869:Microtubule-Associated Proteins; C064993:ROD protein, Drosophila; D014157:Transcription Factors; C087289:gl protein, Drosophila