title: Cortical laminar necrosis and central pontine myelinolysis in a patient with Sheehan syndrome and severe hyponatremia.
abstract: Hypoxic encephalopathy and osmotic demyelination are independent clinical entities. We describe a rare case with these two complications as demonstrated by magnetic resonance imaging (MRI). A 58-year-old woman had adrenal crises twice a decade due to Sheehan syndrome. At the second crisis, hyponatremia was remarkable with consciousness disturbance which was rapidly corrected by intravenous administration of glucocorticoid and hypertonic saline. The maneuver improved consciousness disturbance, but resulted in hypokalemic ventricular fibrillation with circulatory failure. After the normalization of the circulation, however, her consciousness level deteriorated again. Repeated brain MRI revealed acute and chronic phases of cortical laminar necrosis and central pontine myelinolysis.
authors.affiliation: Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai.
authors.forename: M
authors.initials: M
authors.lastname: Shoji
authors.forename: T
authors.initials: T
authors.lastname: Kimura
authors.forename: K
authors.initials: K
authors.lastname: Ota
authors.forename: M
authors.initials: M
authors.lastname: Ohta
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Funyu
authors.forename: T
authors.initials: T
authors.lastname: Mori
authors.forename: M
authors.initials: M
authors.lastname: Tateyama
authors.forename: K
authors.initials: K
authors.lastname: Abe
mesh_terms: D001921:Brain / Q000473:pathology; D003711:Demyelinating Diseases / Q000209:etiology / Q000473:pathology*; D004829:Epilepsy, Generalized / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000209:etiology / Q000473:pathology*; D007018:Hypopituitarism / Q000150:complications / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009336:Necrosis; D011149:Pons / Q000473:pathology*