Atrial natriuretic factor increases peritoneal dialysis efficiency in nephrectomized rats.
The effect of atrial natriuretic factor (ANF) on peritoneal dialysis was studied in bilaterally nephrectomized rats. ANF was injected prior to every dialysis exchange and blood samples were obtained before the instillation of the dialysis solution and during the collection of dialysates. Urea, creatinine, potassium, and sodium were determined in both plasma and dialysates. Results showed that ANF increased the plasma clearance of all studied solutes, probably through vasodilation. Solute clearances showed a gradual increase with each dialysis exchange in both control and experimental animals. Therefore, ANF plasma levels were assayed before, during, and after peritoneal dialysis in a control group of nephrectomized rats to determine whether ANF plasma levels were modified during dialysis. Plasma ANF values were higher during and after peritoneal dialysis, though basal levels were similar to those of non-nephrectomized rats. These results suggest the release of endogenous ANF from the cardiac atria during peritoneal dialysis. The present results suggest that ANF may be of potential interest in the clinical field to increase the efficiency of peritoneal dialysis in man.
Bianciotti
L G
LG
Cátedra de Fisiopatología, Universidad de Buenos Aires, Argentina.
Vatta
M S
MS
Bengochea
L A
LA
Puyo
A M
AM
Fernandez
B E
BE
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D003404:Creatinine / Q000378:metabolism; D015314:Dialysis Solutions; D008297:Male; D009392:Nephrectomy; D010530:Peritoneal Dialysis; D011188:Potassium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000378:metabolism; D014508:Urea / Q000378:metabolism
D015314:Dialysis Solutions; D009320:Atrial Natriuretic Factor; D014508:Urea; D012964:Sodium; D003404:Creatinine; D011188:Potassium