Comparative estimation of the neurotoxic risks of N-hexane and N-heptane in rats and humans based on the formation of the metabolites 2,5-hexanedione and 2,5-heptanedione.
Filser
J G
JG
GSF-Institute of Toxicology, Oberschleissheim, Germany.
Csanády
G A
GA
Dietz
W
W
Kessler
W
W
Kreuzer
P E
PE
Richter
M
M
Störmer
A
A
D000280:Administration, Inhalation; D000328:Adult; D000818:Animals; D001822:Body Burden; D003432:Cross-Linking Reagents / Q000737:chemistry / Q000378:metabolism; D006207:Half-Life; D006536:Heptanes / Q000493:pharmacokinetics* / Q000633:toxicity*; D006586:Hexanes / Q000493:pharmacokinetics* / Q000633:toxicity*; D006588:Hexanones / Q000737:chemistry / Q000378:metabolism / Q000652:urine; D006801:Humans; D007659:Ketones / Q000737:chemistry / Q000378:metabolism / Q000652:urine; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology; D011758:Pyrroles / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D018570:Risk Assessment
D003432:Cross-Linking Reagents; D006536:Heptanes; D006586:Hexanes; D006588:Hexanones; D007659:Ketones; D011758:Pyrroles; C011841:2,5-heptanedione; C026385:n-hexane; C028618:n-heptane; C011269:2,5-hexanedione