title: Assessing the effects of 10 percent carbamide peroxide on oral soft tissues.
abstract: To examine the effects of a 10 percent carbamide peroxide bleaching gel on the oral soft tissues, the authors conducted a prospective, double-blind, placebo-controlled clinical investigation. Fifty-two patients completed a two-week treatment regimen, applying either a placebo or a 10 percent carbamide peroxide gel in a soft tray for eight hours a day. Clinicians examined the participants' oral soft tissues at baseline and one week, two weeks and six weeks after the first treatment. The examiners recorded the Silness and Löe plaque and gingival indexes, nonmarginal gingival index and nongingival oral mucosal index at each examination. The data collected at these intervals did not indicate that any soft tissue damage had occurred as a result of the bleaching regimen.
authors.affiliation: Department of Oral Rehabilitation, School of Dentistry, Medical College of Georgia, Augusta 30912-1260, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Curtis
authors.forename: G L
authors.initials: GL
authors.lastname: Dickinson
authors.forename: M C
authors.initials: MC
authors.lastname: Downey
authors.forename: C M
authors.initials: CM
authors.lastname: Russell
authors.forename: V B
authors.initials: VB
authors.lastname: Haywood
authors.forename: M L
authors.initials: ML
authors.lastname: Myers
authors.forename: M H
authors.initials: MH
authors.lastname: Johnson
mesh_terms: D000328:Adult; D000077463:Carbamide Peroxide; D003774:Dental Plaque Index; D004311:Double-Blind Method; D004338:Drug Combinations; D005881:Gingiva / Q000187:drug effects*; D006801:Humans; D009061:Mouth Mucosa / Q000187:drug effects*; D010512:Periodontal Index; D010545:Peroxides / Q000009:adverse effects*; D018709:Statistics, Nonparametric; D014073:Tooth Bleaching / Q000009:adverse effects / Q000379:methods*; D014508:Urea / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D004338:Drug Combinations; D010545:Peroxides; D000077463:Carbamide Peroxide; D014508:Urea