Understanding and controlling the cell cycle with natural products.
Small molecule natural products have aided in the discovery and characterization of many proteins critical to the progression and maintenance of the cell cycle. Identification of the direct target of a natural product gives scientists a tool to control a specific aspect of the cell cycle, thus facilitating the study of the cell-cycle machinery.
Hung
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Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Jamison
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Schreiber
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D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology* / Q000502:physiology; D002453:Cell Cycle / Q000187:drug effects* / Q000502:physiology; D004249:DNA Damage; D015394:Molecular Structure; D019384:Nucleic Acid Synthesis Inhibitors / Q000737:chemistry / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
D001688:Biological Products; D019384:Nucleic Acid Synthesis Inhibitors