title: Failure of prostatitis treatment secondary to probable ciprofloxacin-sucralfate drug interaction.
abstract: Metal cations such as aluminum, magnesium, ferrous sulfate, and zinc are thought to form chelation complexes with fluoroquinolone antibiotics and prevent the drugs from being absorbed. Sucralfate, which has a high aluminum content, reduces the bioavailability of ciprofloxacin to approximately 4%. The concomitant administration of ciprofloxacin and sucralfate resulted in treatment failure for a patient with prostatitis and a subsequent 5-day hospitalization. Fluoroquinolone antibiotics should be administered at least 2 hours before agents containing metal cations to allow for their absorption. In addition, sucralfate should not be administered less than 6 hours before fluoroquinolone antibiotic administration.
authors.affiliation: Department of Family Medicine, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Spivey
authors.forename: D M
authors.initials: DM
authors.lastname: Cummings
authors.forename: N R
authors.initials: NR
authors.lastname: Pierson
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects*; D002939:Ciprofloxacin / Q000009:adverse effects*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005765:Gastrointestinal Agents / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011472:Prostatitis / Q000188:drug therapy*; D013290:Streptococcal Infections / Q000188:drug therapy; D013392:Sucralfate / Q000009:adverse effects*
chemical_list: D000890:Anti-Infective Agents; D005765:Gastrointestinal Agents; D013392:Sucralfate; D002939:Ciprofloxacin