Adaptation of a conjugal transfer system for the export of pathogenic macromolecules.
Conjugal transfer of bacterial plasmids requires a pore through which DNA can traverse the envelopes of the donor and recipient cells. Recent studies indicate that these pores, which are composed of approximately ten proteins, are evolutionarily related to the transport systems required for the transfer of oncogenic T-DNA from Agrobacterium tumefaciens to plant cells and for toxin secretion from Bordetella pertussis.
Winans
S C
SC
Section of Microbiology, Cornell University, Ithaca, NY 14853, USA. scw2@cornell.edu
Burns
D L
DL
Christie
P J
PJ
D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D001427:Bacterial Toxins / Q000378:metabolism*; D001886:Bordetella pertussis / Q000737:chemistry / Q000235:genetics / Q000472:pathogenicity; D003227:Conjugation, Genetic; D004269:DNA, Bacterial / Q000378:metabolism; D019143:Evolution, Molecular; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics; D008957:Models, Genetic; D018933:Pili, Sex / Q000737:chemistry; D010957:Plasmids / Q000235:genetics; D018272:Porins / Q000737:chemistry / Q000235:genetics; D012231:Rhizobium / Q000235:genetics; D037521:Virulence Factors
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D004269:DNA, Bacterial; D008565:Membrane Proteins; D018272:Porins; D037521:Virulence Factors; C094736:ptlF protein, Bordetella pertussis