RNA surfaces as functional mimetics of proteins.
Accumulating evidence suggests that RNA molecules can form surfaces that mimic those of proteins. Reactivity of autoantibodies with RNA surfaces may be due to cross-reactivity between a protein epitope and the RNA. The structural mimicry detected by an autoantibody may reflect functional mimicry.
Keene
J D
JD
Department of Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
D000818:Animals; D001323:Autoantibodies; D001483:Base Sequence; D003429:Cross Reactions; D000939:Epitopes; D006801:Humans; D008954:Models, Biological; D018716:Molecular Mimicry; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D011506:Proteins / Q000737:chemistry* / Q000276:immunology; D012313:RNA / Q000737:chemistry* / Q000235:genetics / Q000276:immunology; D012333:RNA, Messenger / Q000737:chemistry / Q000276:immunology; D012367:RNA, Viral / Q000737:chemistry / Q000276:immunology; D013499:Surface Properties
D001323:Autoantibodies; D000939:Epitopes; D011506:Proteins; D012333:RNA, Messenger; D012367:RNA, Viral; D012313:RNA