title: Isolation and chromosomal mapping of a mouse homolog of the Batten disease gene CLN3.
abstract: We describe the isolation and chromosomal mapping of a mouse homolog of the Batten disease gene, CLN3. Like its human counterpart, the mouse cDNA contains an open reading frame of 1314 bp encoding a predicted protein product of 438 amino acids. The mouse and human coding regions are 82 and 85% identical at the nucleic acid and amino acid levels, respectively. The mouse gene maps to distal Chromosome 7, in a region containing genes whose homologs are on human chromosome 16p12, where CLN3 maps. Isolation of a mouse CLN3 homolog will facilitate the creation of a mouse model of Batten disease.
authors.affiliation: Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown 02129, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Lee
authors.forename: K R
authors.initials: KR
authors.lastname: Johnson
authors.forename: T J
authors.initials: TJ
authors.lastname: Lerner
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D018076:DNA, Complementary; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins; D051379:Mice; D008810:Mice, Inbred C57BL; D018832:Molecular Chaperones; D008969:Molecular Sequence Data; D009472:Neuronal Ceroid-Lipofuscinoses / Q000235:genetics*; D011506:Proteins / Q000235:genetics*
chemical_list: C102229:CLN3 protein, mouse; D018076:DNA, Complementary; D008562:Membrane Glycoproteins; D018832:Molecular Chaperones; D011506:Proteins