Placebo-controlled, randomized, double-blind study of intravenous enalaprilat efficacy and safety in acute cardiogenic pulmonary edema.
BACKGROUND
Converting enzyme inhibitors meet most of the criteria required to be used in acute pulmonary edema. However, they could also induce deleterious effects on renal function and electrolytes. The purpose of this study was to evaluate the efficacy and safety of a single intravenous 2-hour infusion of enalaprilat (1 mg) after an acute pulmonary edema.


RESULTS
This was a placebo-controlled, randomized, double-blind study performed in 20 congestive heart failure patients (New York Heart Association class III or IV). Systemic and regional hemodynamic parameters, biological parameters, and blood gases were measured before and repeatedly after the onset of infusion. Compared with placebo, enalaprilat decreased pulmonary capillary wedge pressure (-37% versus -10%, P = .001), diastolic and mean systemic blood pressures (-21% versus 0%, P = .009, and -18% versus -1%, P = .026, respectively), diastolic and mean pulmonary blood pressures (-21% versus -8%, P = .040; -18% versus -9%, P = .046), and brachial and renal resistances (-44% versus -14%, P = .017, and -22% versus -2%, P = .014, respectively); increased brachial and renal blood flows (+77% versus +8%, P = .036, and +12% versus 0%, P = .043, respectively), arterial oxygen tension (+2% versus -16%, P = .041), and arterial oxygen saturation (+1% versus -2%, P = .045); and tended to decrease rate-pressure product (-19% versus -7%, P = .076), increase brachial artery diameter (+13% versus 0%, P = .081), and improve intrapulmonary shunt (-18% versus +16%, P = .080). Enalaprilat did not affect cardiac output or carotid or hepatosplanchnic hemodynamics.


CONCLUSIONS
Early administration of enalaprilat is effective and well tolerated in acute pulmonary edema.
Annane
D
D
Service de Réanimation Médicale, Hôpital Raymond Poincaré, Garches, France.
Bellissant
E
E
Pussard
E
E
Asmar
R
R
Lacombe
F
F
Lanata
E
E
Madonna
O
O
Safar
M
M
Giudicelli
J F
JF
Gajdos
P
P
D000208:Acute Disease; D000368:Aged; D004311:Double-Blind Method; D015773:Enalaprilat / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005740:Gases / Q000097:blood; D006333:Heart Failure / Q000150:complications* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006728:Hormones / Q000097:blood; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D010919:Placebos; D011652:Pulmonary Circulation / Q000187:drug effects; D011654:Pulmonary Edema / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology
D005740:Gases; D006728:Hormones; D010919:Placebos; D015773:Enalaprilat