title: Coronary microcirculation during left heart bypass with a centrifugal pump.
abstract: To estimate coronary microcirculation during left heart bypass (LHB), we performed an experimental comparison study of LHB and intraaortic balloon pumping (IABP). LHB was performed with a BioMedicus BP-80 pump supporting half of the flow of cardiac output whereas the IABP was pumped in a 1:1 mode for cardiogenic shock in a swine model. Coronary circulations were analyzed by electromagnetic flowmeter, pulsed Doppler velocimeter, and laser Doppler flowmeter. Left ventricular end-diastolic pressure (LVEDP) was reduced significantly by LHB. Although there was no significant difference in epicardial flow between the LHB and IABP groups, endo cardial flow was increased significantly by LHB. In the LHB group, the systolic reverse wave of the coronary velocity called a myocardial invalid circulation was reduced remarkably. There was a significant inverse correlation between endocardial flow and LVEDP. These results suggested that LHB was more effective for myocardial microcirculation than was IABP.
authors.affiliation: Second Department of Surgery, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hata
authors.forename: M
authors.initials: M
authors.lastname: Shiono
authors.forename: Y
authors.initials: Y
authors.lastname: Orime
authors.forename: K
authors.initials: K
authors.lastname: Nakata
authors.forename: A
authors.initials: A
authors.lastname: Sezai
authors.forename: H
authors.initials: H
authors.lastname: Yamada
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: Y
authors.initials: Y
authors.lastname: Sezai
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002498:Centrifugation; D003326:Coronary Circulation / Q000502:physiology*; D004195:Disease Models, Animal; D018611:Heart Bypass, Left / Q000379:methods*; D006353:Heart-Assist Devices / Q000592:standards*; D007423:Intra-Aortic Balloon Pumping / Q000379:methods*; D017078:Laser-Doppler Flowmetry; D012770:Shock, Cardiogenic / Q000628:therapy*; D013552:Swine