title: Human endopeptidase (THOP1) is localized on chromosome 19 within the linkage region for the late-onset alzheimer disease AD2 locus.
abstract: A cDNA encoding the rat endopeptidase 24.15 was used to determine the chromosomal localization of the respective human gene. Hybridization to DNA from human-rodent somatic cell hybrids assigned the human gene to chromosome 19. Fluorescence in situ hybridization on human metaphase chromosomes localized the human endopeptidase 24.15 to 19q13.3.
authors.affiliation: Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA.
authors.forename: B
authors.initials: B
authors.lastname: Meckelein
authors.forename: H A
authors.initials: HA
authors.lastname: de Silva
authors.forename: A D
authors.initials: AD
authors.lastname: Roses
authors.forename: P N
authors.initials: PN
authors.lastname: Rao
authors.forename: M J
authors.initials: MJ
authors.lastname: Pettenati
authors.forename: P T
authors.initials: PT
authors.lastname: Xu
authors.forename: R
authors.initials: R
authors.lastname: Hodge
authors.forename: M J
authors.initials: MJ
authors.lastname: Glucksman
authors.forename: C R
authors.initials: CR
authors.lastname: Abraham
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics; D000818:Animals; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D010450:Endopeptidases / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D051381:Rats
chemical_list: D010450:Endopeptidases