Changes in the surface carbohydrate composition and exposure of anionic groups caused by beta-lactam antibiotics in streptococci.
Upon the addition of beta-lactam antibiotics at concentrations that caused a 50% reduction in the dry weight, beta-haemolytic streptococci produced increased amount of rhamnose, though the hexosamine content remained unchanged. These sugars are components of C-carbohydrate. Sialic acid content also increased in group B streptococcal surfaces and penicillin treatment generated new accessible surface sialic acid residues.
Figueiredo
A M
AM
Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Brazil.
Ferreira-Carvalho
B T
BT
Alviano
C S
CS
Angluster
J
J
Silva Filho
F C
FC
Benchetrit
L C
LC
D000838:Anions; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D050260:Carbohydrate Metabolism; D006595:Hexosamines / Q000378:metabolism; D012210:Rhamnose / Q000378:metabolism; D012794:Sialic Acids / Q000378:metabolism; D013292:Streptococcus agalactiae / Q000187:drug effects* / Q000378:metabolism*; D013499:Surface Properties; D047090:beta-Lactams
D000838:Anions; D000900:Anti-Bacterial Agents; D006595:Hexosamines; D012794:Sialic Acids; D047090:beta-Lactams; D012210:Rhamnose