Rush immunotherapy with house dust extract in patients with mild extrinsic asthma.
Rush immunotherapy (RIT) with house dust extract was given to 15 patients with mild extrinsic or mixed asthma. Every patient was strongly positive for IgE on the radioimmunosorbent test and sensitive to house dust extract on the scratch skin test. Nine patients were positive on the bronchial provocation test to house dust extract and 6 could not be examined. All patients did not drop out and got to house dust extract solution 10(-1) within 1 week. The symptom-medication scores decreased significantly after RIT. During RIT 1 patient developed a mild asthmatic attack and 3 patients developed generalized skin reaction. Eight weeks later, the threshold for house dust-provoked bronchoconstriction increased in 9 patients, but did not in 3 patients. The blood eosinophil count and blood histamine level significantly decreased. We conclude that RIT is able to raise antigen concentrations for a short periods and effective but not risky for mild asthma.
Hirokawa
Y
Y
Department of Pulmonology, Tokai University School of Medicine, Isehara, Japan.
Kondo
T
T
Kobayashi
I
I
Ohta
Y
Y
D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000008:administration & dosage* / Q000627:therapeutic use*; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001249:Asthma / Q000503:physiopathology / Q000628:therapy*; D001980:Bronchi / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D016084:Bronchoconstriction / Q000502:physiology; D004205:Cromolyn Sodium / Q000008:administration & dosage / Q000627:therapeutic use; D004391:Dust / Q000009:adverse effects*; D004804:Eosinophils; D005260:Female; D006632:Histamine / Q000097:blood; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007167:Immunotherapy; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011852:Radioallergosorbent Test; D012129:Respiratory Function Tests
D000485:Allergens; D018927:Anti-Asthmatic Agents; D004391:Dust; D007074:Immunoglobulin G; D006632:Histamine; D004205:Cromolyn Sodium