Prostaglandin release from rat femurs after implantation of hydroxylapatite and aluminium oxide ceramics.
The bony reaction after implantation of uncemented ceramics is of special interest. Therefore porous and dense hydroxylapatite and aluminium oxide ceramics were implanted in rat femurs. One group received no surgical manipulation and another with a sham procedure where no ceramics were implanted served as controls. After 6 and 10 days the rat femurs were harvested and the release of PGE2 and 6-keto-PGF1 alpha was measured with specific radioimmunoassays. Decrease in the release of PGE2 from day 6 to day 10 was present in all three implants. In contrast, 6-keto-PGF1 alpha increased from day 6 to day 10. Comparing the ceramic types an increase in 6-keto-PGF1 alpha release was seen in the porous hydroxylapatite group. These prostaglandin (PG) release patterns after ceramic implantation are similar to those of fracture healing, but aluminium oxide seems to be inert, while hydroxylapatite, especially the porous type, stimulates 6-keto-PGF1 alpha release.
Wittenberg
J M
JM
Department of Oral and Maxillofacial Surgery, Louisiana State University, Shreveport, USA.
Wittenberg
R H
RH
Osborn
J F
JF
D000537:Aluminum Oxide / Q000494:pharmacology*; D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000502:physiology* / Q000601:surgery; D002516:Ceramics / Q000494:pharmacology*; D015237:Dinoprost / Q000378:metabolism; D015232:Dinoprostone / Q000378:metabolism; D017886:Durapatite / Q000494:pharmacology*; D005269:Femur; D008297:Male; D010000:Osteitis / Q000209:etiology; D011453:Prostaglandins / Q000378:metabolism*; D019736:Prostheses and Implants / Q000009:adverse effects; D051381:Rats; D017207:Rats, Sprague-Dawley
C078129:6-keto-prostaglandin F2alpha; D011453:Prostaglandins; D017886:Durapatite; D015237:Dinoprost; D015232:Dinoprostone; D000537:Aluminum Oxide