title: "Stat." single dose of acyclovir for prevention of herpes simplex.
abstract: A single "stat." 800-mg dose of acyclovir taken at the first sensory signs for either oral or genital herpes simplex regularly prevented lesions from appearing in twenty-six of thirty-two persons known to have recurrent attacks. This dosage schedule is a cost-effective alternative to the long-term daily prophylactic dosing currently recommended.
authors.affiliation: Department of Medicine, Medical College of Ohio, Toledo 43699-0008, USA.
authors.forename: W B
authors.initials: WB
authors.lastname: Shelley
authors.forename: E D
authors.initials: ED
authors.lastname: Shelley
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage / Q000191:economics / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000008:administration & dosage / Q000191:economics / Q000627:therapeutic use*; D018890:Chemoprevention / Q000191:economics; D003362:Cost-Benefit Analysis; D004334:Drug Administration Schedule; D005260:Female; D006558:Herpes Genitalis / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013283:Stomatitis, Herpetic / Q000517:prevention & control*
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir