[Expression of the heat shock protein 70 in inflammatory myopathies].
Heat shock protein 70 (HSP 70) expression was immunohistochemically observed in diseased muscle fibers of 35 patients with dermatomyositis (DM) and 7 with polymyositis (PM). In DM, HSP 70 was localized in the sarcoplasm of type 1 fibers adjacent to the small vessels showing deposits of complement components in 13 patients and in the atrophic fibers at perifascicular regions in 7. HSP 70 was also expressed more preferentially in the small vessels rather than in the sarcoplasm in 13 DM patients. In PM, the expression of HSP 70 was blurred in all fibers including non-necrotic fibers invaded by T cells. In conclusion, HSP 70 is likely more frequently to be expressed in the sarcoplasm of DM than PM due to probable ischemic insults.
Ibi
T
T
Fourth Department of Medicine, Aichi Medical University.
Sahashi
K
K
Ling
J
J
Mitsuma
T
T
D003882:Dermatomyositis / Q000378:metabolism*; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D017285:Polymyositis / Q000378:metabolism*; D012519:Sarcoplasmic Reticulum / Q000378:metabolism
D018840:HSP70 Heat-Shock Proteins