The cell-death machine.
Apoptosis, or programmed cell death, is the physiological process whereby individual cells are deliberately eliminated to achieve homeostasis and proper metazoan development. Numerous genes have recently been identified that are involved in apoptosis: some are believed to encode death effectors, whereas others encode positive or negative regulators of the cell-death machine. Precisely how these various proteins interact in the molecular mechanism of apoptosis remains to be discovered.
Chinnaiyan
A M
AM
University of Michigan Medical School, Department of Pathology, 1301 Catherine Street, Box 0602, Ann Arbor, Michigan 48109, USA.
Dixit
V M
VM
D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D006801:Humans