title: The intensity dependence of the site of maximal energy deposition in focused ultrasound surgery.
abstract: The relationship between spatial peak intensity and the position of ultrasound induced tissue damage was studied in in vitro tissue models, using a 1.69 MHz spherical bowl transducer. The models corresponded to the transabdominal route to the bladder and prostate, which are potential target sites for focused ultrasound surgery. The results confirm that there is a relationship between lesion position and intensity, with lesions forming, under some exposure conditions, ahead of the geometric focus. Forward growth of lesions appears to be due to changes in the absorption characteristics of the tissue in the beam path. Using a computer model, we have demonstrated that the absorption coefficient of the tissue must increase significantly in front of the focus to enable lesions to form ahead of the predicted position. A possible mechanism for this is bubble formation as a result of acoustic cavitation. The effect of nonlinear propagation in the tissue, at the intensities studied, is shown to be relatively small.
authors.affiliation: Joint Department of Physics, Royal Marsden Hospital, Sutton, Surrey, U.K.
authors.forename: N A
authors.initials: NA
authors.lastname: Watkin
authors.forename: G R
authors.initials: GR
authors.lastname: ter Haar
authors.forename: I
authors.initials: I
authors.lastname: Rivens
mesh_terms: D000005:Abdomen; D000042:Absorption; D000818:Animals; D002417:Cattle; D003198:Computer Simulation; D066298:In Vitro Techniques; D008107:Liver Diseases / Q000628:therapy*; D008297:Male; D008954:Models, Biological; D011471:Prostatic Neoplasms / Q000628:therapy*; D013552:Swine; D014464:Ultrasonic Therapy / Q000379:methods*; D001749:Urinary Bladder Neoplasms / Q000628:therapy*