Relationship between glutathione and DL alpha-lipoic acid against cadmium-induced hepatotoxicity.
Cadmium, a divalent metal toxicant, preferentially localizes in hepatocytes and causes liver injury. DL alpha-lipoic acid is a dithiol which is effective in rendering protection against cadmium-associated liver damage, by virtue of its two sulfhydryl moieties. Lipoate was administered to cadmium-exposed rats which were either prior administered with buthionine sulfoximine to deplete liver glutathione or not. During lipoate treatment, significant protection was rendered against cadmium toxicity even under glutathione-depleted experimental condition. This highlights the antioxidant property of lipoic acid and its efficacy in mitigating cadmium-associated liver assault even in the absence of glutathione synthesis.
Sumathi
R
R
Department of Medical Biochemistry, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, India.
Baskaran
G
G
Varalakshmi
P
P
D000818:Animals; D019328:Buthionine Sulfoximine / Q000494:pharmacology; D002104:Cadmium / Q000633:toxicity*; D005978:Glutathione / Q000502:physiology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D008063:Thioctic Acid / Q000502:physiology*
D002104:Cadmium; D019328:Buthionine Sulfoximine; D008063:Thioctic Acid; D005978:Glutathione