title: Identification of C31 and C32 sterols in Pneumocystis carinii hominis-infected human lungs.
abstract: Two sterols in autopsied whole lung specimens obtained from Pneumocystis carinii pneumonia patients were detected by gas-liquid chromatography and their structures were elucidated by mass spectrometry and nuclear magnetic resonance spectrometry. Both were in the lanosterol series; the C31 sterol, with a methyl group at C-24, was identified as euphorbol, and the more abundant C32 sterol, with an ethyl group at C-24, is given the trivial name pneumocysterol.
authors.affiliation: Dept. Biol. Sci., Univ. Cincinnati, OH 45221, USA.
authors.forename: E S
authors.initials: ES
authors.lastname: Kaneshiro
authors.forename: M
authors.initials: M
authors.lastname: Swonger
authors.forename: G
authors.initials: G
authors.lastname: Kreishman
authors.forename: E
authors.initials: E
authors.lastname: Brooks
authors.forename: K
authors.initials: K
authors.lastname: Jayasimhulu
authors.forename: E J
authors.initials: EJ
authors.lastname: Parish
authors.forename: D H
authors.initials: DH
authors.lastname: Beach
mesh_terms: D002849:Chromatography, Gas; D006801:Humans; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000032:analysis; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D011020:Pneumonia, Pneumocystis / Q000378:metabolism* / Q000473:pathology
chemical_list: C102334:pneumocysterol; D007810:Lanosterol