Effect of orally administered heat-killed Enterococcus Faecalis FK-23 preparation on neutropenia in dogs treated with cyclophosphamide.
Dogs injected intravenously for 3 days with cyclophosphamide (CY) at a dose of 10 mg/kg were given 100 mg/kg of Enterococcus faecalis FK-23 preparation (FK-23) perorally for 14 days to confirm the beneficial effects of the latter drug in neutropenic dogs when orally administered. Although FK-23 treatment did not inhibit CY-induced neutropenia, it augmented neutrophil-reconstituting capacity in these dogs. Increases in the myeloid/ erythroid ratio and neutrophilic lineages were found in the bone marrow of FK-23 administered dogs. The oral administration significantly restored the reduced activity of neutrophil phagocytosis and chemiluminescence in dogs treated with CY. These findings indicate that FK-23 administered perorally not only augments neutrophil reconstitution through the activation of bone marrow but also functions in dogs treated with CY. It may thus be a useful supportive agent to reduce the adverse side-effects associated with the administration of chemotherapeutic agents such as CY.
Hasegawa
T
T
Veterinary Teaching Hospital, Faculty of Agriculture, Miyazaki University, Japan.
Kanasugi
H
H
Hidaka
M
M
Yamamoto
T
T
Abe
S
S
Yamaguchi
H
H
D000284:Administration, Oral; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000009:adverse effects; D001853:Bone Marrow / Q000502:physiology; D003520:Cyclophosphamide / Q000494:pharmacology*; D004285:Dogs; D013293:Enterococcus faecalis; D004768:Enterotoxins / Q000008:administration & dosage*; D009503:Neutropenia / Q000097:blood*; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology
D001428:Bacterial Vaccines; D004768:Enterotoxins; D003520:Cyclophosphamide