title: [Changes in the spectrum of AIDS-defining diseases in Spain].
abstract: BACKGROUND
  Since the late 1980s the use of prophylaxis against several AIDS-diagnostic diseases has been recommended. In order to detect the impact of these measures we analyzed the shifts in the spectrum of AIDS-diagnostic diseases in Spain.
  
  
  METHODS
  AIDS cases (CDC-1987) among patients over 12 years of age diagnosed in Spain during the period 1988-1993 were studied. Number and percentage of annual AIDS cases corresponding to each reported AIDS-diagnostic disease were analyzed. Annual percentage trends were assessed by means of chi 2 trend test and logistic regression adjusting for possible changes in distribution by transmission category, sex, and age-group.
  
  
  RESULTS
  Annual incidence in most of AIDS-defining diseases rose over the period 1988-1993, although the proportion of cases in which the respective conditions appeared as AIDS-diagnostic diseases exhibited declining trends (p < 0.05) in: invasive candidiasis, Herpes simplex virus infection, isosporidiasis, Pneumocystis carinii pneumonia, extrapulmonary tuberculosis, Salmonella (non-typhoid) septicemia, HIV encephalopathy and wasting syndrome. Increases were observed in the proportion of Mycobacterium avium complex disease and progressive multifocal leukoencephalopathy (p < 0.05).
  
  
  CONCLUSIONS
  Some shifts in the spectrum of diseases are noted, which could be due to primary prophylaxis. Efforts should be targeted to improve coverage and compliance, and to develop guidelines of prophylaxis against the remaining diseases.
authors.affiliation: Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid.
authors.forename: J
authors.initials: J
authors.lastname: Castilla
authors.forename: A
authors.initials: A
authors.lastname: Gutiérrez
authors.forename: I
authors.initials: I
authors.lastname: Noguer
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology*; D000293:Adolescent; D000328:Adult; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D013030:Spain / Q000453:epidemiology