On the origin of heterogeneity of lipofuscin fluorophores and their possible interrelations.
A comparison of the response of different cell types (thymus, spleen, liver, tumor) to the development of oxidative stress was investigated on an experimental model of tumor growth in vivo. Only spleen cells exhibited the yellow-red fluorescent pigment with high resistance to oxidative stress (as is typical for age-related lipofuscin pigment). Under oxidative stress, the cytoplasm in normal cells showed a tendency forward increased levels of fluorescent products of protein or lipid peroxidation, which was opposite from the response of tumor cells. In the present paper a novel hypothesis of lipofuscinogenesis is developed where oxidative stress is considered to be a trigger for switching on some adaptive cell pathways whose activity is associated with the induction of specific groups of cellular fluorophores.
Schwartsburd
P M
PM
Institute of Theor. & Exper. Biophysics, Russian Acad. of Science, Puschino.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism / Q000473:pathology*; D002455:Cell Division; D008062:Lipofuscin / Q000378:metabolism*; D008099:Liver / Q000166:cytology; D051379:Mice; D009374:Neoplasms, Experimental; D018384:Oxidative Stress / Q000502:physiology; D013154:Spleen / Q000166:cytology; D013950:Thymus Gland / Q000166:cytology; D014407:Tumor Cells, Cultured / Q000378:metabolism*
D008062:Lipofuscin