Benzene-induced bone marrow cell depression caused by inhibition of the conversion of pre-interleukins-1alpha and -1beta to active cytokines by hydroquinone, a biological reactive metabolite of benzene.
Niculescu
R
R
Department of Biochemistry and Molecular Biology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Renz
J F
JF
Kalf
G F
GF
D000818:Animals; D001554:Benzene / Q000633:toxicity*; D001711:Biotransformation; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002273:Carcinogens / Q000633:toxicity*; D016207:Cytokines / Q000096:biosynthesis*; D006801:Humans; D006873:Hydroquinones / Q000378:metabolism* / Q000494:pharmacology; D007375:Interleukin-1 / Q000378:metabolism*; D009153:Mutagens / Q000378:metabolism* / Q000494:pharmacology
D002273:Carcinogens; D016207:Cytokines; D006873:Hydroquinones; D007375:Interleukin-1; D009153:Mutagens; D001554:Benzene; C031927:hydroquinone