[Immunological reactivity and the hypophyseal-ovarian system in patients with circumscribed scleroderma].
Immune responsiveness and functional activity of hypophyseal-gonadal system were studied in 30 women of childbearing age presenting with circumscribed scleroderma. The findings obtained are consistent with a clinical picture of immunity T-system deficiency suggesting a role for T-lymphocyte subpopulations in derangement of immune regulation. Alterations in hormonal homeostasis were manifested by hypoestrogenia and imbalance of gonadotrophic hormones. Relationship of sex hormones to indices for cell-mediated immunity is discussed as is their role in the pathogenesis of this medical condition.
Bolotnaia
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D000328:Adult; D000937:Antigen-Antibody Reactions; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D006801:Humans; D008875:Middle Aged; D010053:Ovary / Q000503:physiopathology*; D010902:Pituitary Gland / Q000503:physiopathology*; D012397:Rosette Formation; D012594:Scleroderma, Localized / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D013601:T-Lymphocytes / Q000276:immunology