Arisugacins A and B, novel and selective acetylcholinesterase inhibitors from Penicillium sp. FO-4259. II. Structure elucidation.
The structures of new acetylcholinesterase inhibitors, arisugacins A and B, were elucidated by NMR study. Arisugacins have a (4aR,6aR,12aS,12bS)-4a,6,6a,12,12a, 12b-hexahydro-4a,12a-dihydroxy-4,4,6a,12b-tetramethyl-4H,11H -naphtho[2,1-b] pyrano[3,4-e]pyran-1,11(5H)-dione moiety in common and 3,4-dimethoxyphenyl or 4-methoxyphenyl residues are attached to C-9 of the moiety.
Kuno
F
F
Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
Shiomi
K
K
Otoguro
K
K
Sunazuka
T
T
Omura
S
S
D002800:Cholinesterase Inhibitors / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010407:Penicillium / Q000378:metabolism*; D011714:Pyrans / Q000737:chemistry*
D002800:Cholinesterase Inhibitors; D011714:Pyrans; C095353:arisugacin