Cyclosporine A decreases kallikrein and BK2 mRNA expression in the rat renal cortex.
The effect of subcutaneous injection of cyclosporine (20 mg/kg/day for 3 days) on the expression of kallikrein (Kal) and bradykinin 2 receptor (BK2) mRNA in the rat renal cortex was examined. CsA decreased significantly Kal and BK2 mRNA expression in the kidney cortex. These results indicate that the kallikrein-kinin system may participate in the genesis or the aggravation of the renal haemodynamic effect induced by long term administration of CsA.
Bompart
G
G
INSERM U388 Institut Louis Bugnard, CHU Rangueil, Toulouse, France.
Tack
I
I
Marin Castaño
E
E
Pesquero
J B
JB
Girolami
J P
JP
Bascands
J L
JL
D000199:Actins / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D000818:Animals; D065168:Bradykinin Receptor Antagonists; D016572:Cyclosporine / Q000494:pharmacology*; D007610:Kallikreins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D007672:Kidney Cortex / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D012333:RNA, Messenger / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018002:Receptors, Bradykinin / Q000096:biosynthesis*
D000199:Actins; D065168:Bradykinin Receptor Antagonists; D012333:RNA, Messenger; D018002:Receptors, Bradykinin; D016572:Cyclosporine; D007610:Kallikreins