Effects of dietary restriction on experimental gastric mucosal injury in Fischer 344 rats.
The present study was designed to determine whether dietary restriction would render rats more resistant to experimental gastric mucosal injury induced by either aspirin or acidified ethanol. We have found that dietary restriction rendered rats more resistant to experimental gastric mucosal injury, and that dietary restriction prevented decreases in endogenous mucosal antioxidants (such as glutathione) and energy stores (such as adenosine triphosphate) in rat stomachs that had been injured by acidified ethanol. Our findings suggest that dietary restriction may reverse some of the age-related reductions in gastric mucosal protective factors and thereby may render the aged stomach more resistant to experimental injury.
Lee
M
M
Department of Medicine, University of Texas Health Science Center, San Antonio 78284-7878, USA.
Devi
B G
BG
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity*; D001241:Aspirin / Q000633:toxicity*; D002149:Energy Intake; D000431:Ethanol / Q000633:toxicity*; D005753:Gastric Mucosa / Q000187:drug effects*; D008297:Male; D011897:Random Allocation; D051381:Rats; D011916:Rats, Inbred F344
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000431:Ethanol; D001241:Aspirin