title: Hypocholesterolemia is not associated with neurotoxicity in renal transplant patients.
abstract: Cyclosporine-associated neurotoxicity has been reported in recipients of solid organ and bone marrow transplantation. Neurotoxicity during cyclosporine therapy has been suggested to be associated with low levels of serum total cholesterol (TC). We report seven hypocholesterolemic (TC < 150 mg/dl) renal transplant recipients who remained asymptomatic during cyclosporine therapy. Three of these patients were hypocholesterolemic at the time of transplantation and received intravenous cyclosporine as induction therapy. The other four patients became hypocholesterolemic > or = 9 months after renal-transplantation. None of these patients developed neurologic signs or symptoms during cyclosporine therapy. Our short and long-term observations in renal transplant recipients suggest that perhaps factors other than low cholesterol levels may be responsible for cyclosporine-associated neurotoxicity.
authors.affiliation: Department of Internal Medicine, University of Missouri Columbia, USA.
authors.forename: H S
authors.initials: HS
authors.lastname: Trivedi
authors.forename: S M
authors.initials: SM
authors.lastname: Lal
authors.forename: N
authors.initials: N
authors.lastname: Gupta
authors.forename: G
authors.initials: G
authors.lastname: Ross
mesh_terms: D000284:Administration, Oral; D000328:Adult; D044383:Black People; D001812:Blood-Brain Barrier / Q000187:drug effects; D002784:Cholesterol / Q000097:blood*; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D007275:Injections, Intravenous; D007676:Kidney Failure, Chronic / Q000628:therapy*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D044465:White People
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D002784:Cholesterol