IL-1 and anti-inflammatory drugs modulate A beta cytotoxicity in PC12 cells.
We studied the effect of the inflammatory cytokine interleukin-1 beta (IL-1) and several anti-inflammatory drugs on amyloid beta-peptide (A beta) cytotoxicity. Incubation of PC12 cells with 10(-6) M A beta 1-42 for 24 h reduced viabilty to 36%; coincubation with 10(-7) M IL-1 further reduced viability to 13% of baseline. With preincubation of PC12 cells with the drugs indomethacin, dexamethasone and chloroquine, reduction in viability was limited to 51%, 48% and 44%, respectively, compared to 32% with A beta alone. These experiments support further study of anti-inflammatory therapy in Alzheimer's disease.
Fagarasan
M O
MO
Department of Psychiatry, Mount Sinai Medical Center, New York, NY 10029, USA.
Aisen
P S
PS
D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D007375:Interleukin-1 / Q000494:pharmacology*; D016716:PC12 Cells / Q000187:drug effects*; D051381:Rats
D016229:Amyloid beta-Peptides; D000893:Anti-Inflammatory Agents; D007375:Interleukin-1