Plasma triglycerides cosegregate with erythrocyte sodium content in F2 rats of HTG x Lewis cross.
The possible association of plasma lipids (triglycerides and cholesterol) with erythrocyte Na+ content (Na+i) and/or with alterations in red cell Na+ and K+ (Rb+) transport was studied in a population of F2 hybrids obtained by crossing hypertensive Prague hereditary hypertriglyceridaemic (HTG) rats with normotensive Lewis rats. The obtained data indicated a strong cosegregation (p < 0.001) of plasma triglycerides with erythrocyte Na+ content. This was the cause for the close correlation of plasma triglycerides with the Na(+)-K+ pump activity (measured as ouabain-sensitive Na+ extrusion). On the contrary, there was only marginal association (p < 0.05) of erythrocyte Na+ content with plasma cholesterol which was significantly (p < 0.01) related to burnetanide-sensitive Rb+ uptake mediated by the Na(+)-K+ cotransport system. Na+ leak (bumetanide-resistant net Na+ uptake) correlated positively with blood pressure in female but not in male F2 rats. The close association between plasma triglycerides and erythrocyte Na+ content suggests that ion transport alterations might contribute to mechanisms responsible for the cosegregation of blood pressure with plasma triglycerides in HTG x Lewis F2 hybrids.
Zicha
J
J
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Dobesová
Z
Z
Kunes
J
J
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003433:Crosses, Genetic; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D012413:Rubidium / Q000097:blood; D012964:Sodium / Q000097:blood*; D028021:Sodium-Potassium-Chloride Symporters; D014280:Triglycerides / Q000097:blood*
D002352:Carrier Proteins; D028021:Sodium-Potassium-Chloride Symporters; D014280:Triglycerides; D002784:Cholesterol; D012964:Sodium; D012413:Rubidium