[The characteristics of the immunological indices in multiple myeloma during polychemotherapy].
Characteristics are presented of indices for immunologic reactivity in 90 patients with multiplex myeloma. It has been ascertained that in multiplex myeloma there is an imbalance of immunoregulatory cells, increase in the level of circulating immune complexes and the blood serum complementary activity. The most clear-cut deviations from the norm were recordable in B-cellular link of immunity. The patients were assigned to treatment with regimens according to a particular programme in chemotherapy. During the course of treatment the immunologic parameters were getting corrected. But VAD (vincristin+adriamicin+ dexamethasone) -- therapy was associated with suppression of T- and B-cellular link of immunity, which fact was one of the reasons of frequent infectious complications. On the basis of the previous immunologic investigation, the most efficaceous chemotherapy programme is that of VAD.
Abdulkadyrov
K M
KM
Bessmel'tsev
S S
SS
D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000097:blood / Q000187:drug effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
D000936:Antigen-Antibody Complex