Compositional analysis surveillance of eleven brands of enrofloxacin including Baytril for veterinary use.
Lack of consistency in clinical effectiveness of various commercial preparations of enrofloxacin prompted a compositional analysis surveillance of 11 trade marks of this fluoroquinolone using various physicochemical properties and high performance liquid chromatography (HPLC). Only one preparation resembled Baytril (Bayer of Mexico), the original brand of enrofloxacin. Variations in the concentration of enrofloxacin, use of different vehicles, substitution of this fluoroquinolone by ciprofloxacin and variations in pH were found. The use of ciprofloxacin in veterinary medicine is discussed.
Sumano
H
H
Department of Physiology and Pharmacology, Veterinary College, National Autonomous University of Mexico, Mexico City.
Ocampo
L
L
D000818:Animals; D000890:Anti-Infective Agents / Q000032:analysis* / Q000592:standards; D002851:Chromatography, High Pressure Liquid / Q000379:methods / Q000662:veterinary; D002939:Ciprofloxacin / Q000032:analysis / Q000592:standards; D004348:Drug Labeling / Q000592:standards*; D000077422:Enrofloxacin; D024841:Fluoroquinolones; D006863:Hydrogen-Ion Concentration; D011358:Product Surveillance, Postmarketing / Q000592:standards*; D015363:Quinolones / Q000032:analysis* / Q000592:standards; D019155:Veterinary Drugs / Q000032:analysis* / Q000592:standards
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D019155:Veterinary Drugs; D000077422:Enrofloxacin; D002939:Ciprofloxacin