Effect of pulsed electromagnetic fields on bone formation and bone loss during limb lengthening.
We examined the effect of pulsed electromagnetic fields (PEMFs) on bone formation and disuse osteoporosis sustained during limb lengthening in a double-blind study. Seven males (mean age 13 years, range 11-19 years) and six females (mean age 12 years, range 9-19 years) were randomly allocated to receive either an active or an inactive PEMF coil. Limb lengthening was performed by the Villarubbias technique using either a unilateral or circular frame system. Sequential bone density measurements were made using dual energy X-ray absorptiometry and compared to traditional radiographs. Ten segments (eight tibial and two femoral) in seven patients were lengthened under the influence of active coils and eight segments (six tibial and two femoral) in six patients using inactive coils. There was no difference in the rate nor the amount of new bone formed at the site of distraction between the two groups. Bone loss in the segments of bone distal to the lengthening sites was observed in both groups but was significantly more marked using inactive coils (BMD reduced by 23% +/- SEM 3% and 33% +/- 4% control values after one and two months, respectively; p < 0.0001) than using active coils (BMD reduced by 10% +/- 2% at 2 months). These differences were greater at 12 months after surgery (reduced by 54% +/- 5% and 13% +/- 4%, respectively; p < 0.0001). Stimulation with pulsed electromagnetic fields has no effect on the regenerate bone, but does prevent bone loss adjacent to the distraction gap.
Eyres
K S
KS
WHO Collaborating Centre for Metabolic Bone Disease, University of Sheffield Medical School, UK.
Saleh
M
M
Kanis
J A
JA
D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D015519:Bone Density / Q000502:physiology; D001846:Bone Development / Q000502:physiology*; D001852:Bone Lengthening; D002648:Child; D004311:Double-Blind Method; D004574:Electromagnetic Fields; D005260:Female; D005269:Femur / Q000502:physiology; D006801:Humans; D007866:Leg / Q000601:surgery*; D008297:Male; D010024:Osteoporosis / Q000503:physiopathology* / Q000517:prevention & control; D010027:Osteotomy; D011446:Prospective Studies; D013977:Tibia / Q000502:physiology