Effect of transient moderate hyperventilation on dynamic cerebral autoregulation after severe head injury.
OBJECTIVE
This study was undertaken to evaluate the effect of acute moderate hyperventilation on cerebral autoregulation in head-injured patients.


METHODS
Dynamic cerebral autoregulation was analyzed by use of transcranial doppler ultrasonography before and after hyperventilation in 10 patients with severe head injury. All of the patients were artificially ventilated and underwent continuous monitoring of arterial blood pressure, intracranial pressure, and end-tidal carbon dioxide. To test autoregulation, rapid transient decreases in systemic blood pressure were achieved by quickly releasing large blood pressure cuffs that were inflated around both thighs. This resulted in a drop of 24 +/- 6 mm Hg in mean systemic blood pressure, which lasted an average of 49 +/- 24 seconds. Cerebral blood flow velocity was monitored continuously in both middle cerebral arteries by use of transcranial doppler ultrasonography. The percentage change in middle cerebral artery velocity was used as an index of the change in cerebral blood flow during the autoregulatory response. The change in estimated cerebrovascular resistance, immediately after the blood pressure drop, or the rate of regulation was used to analyze the effectiveness of the cerebral autoregulation. This value was calculated by determining the rate of increase in middle cerebral artery velocity during the 1st 5 seconds after a blood pressure drop, relative to the rate of increase of the cerebral perfusion pressure.


RESULTS
The average rate of regulation during normocapnia at pCO2 of 37 mm Hg was 11.4 +/- 5% per second. After reduction of the pCO2 to 28 mm Hg, the average rate of regulation improved significantly (P < 0.001) to 17.7 +/- 6% per second. Autoregulation improved, despite no significant change in the cerebral perfusion pressure during hyperventilation. The degree of improvement in autoregulation was significantly correlated with the CO2 reactivity (r = 0.45, P < 0.05) but did not correlate (r = -0.23, P = 0.33) with the change in arterial pH value after hyperventilation.


CONCLUSIONS
These results confirm the finding that dynamic autoregulation is disturbed in severe head injury and that moderate transient hyperventilation can temporarily improve the efficiency of the autoregulatory response, probably as a result of a transient increase in vascular tone.
Newell
D W
DW
Department of Neurological Surgery, University of Washington School of Medicine, Seattle, USA.
Weber
J P
JP
Watson
R
R
Aaslid
R
R
Winn
H R
HR
D000136:Acid-Base Equilibrium / Q000502:physiology; D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D001921:Brain / Q000098:blood supply*; D001924:Brain Concussion / Q000000981:diagnostic imaging / Q000503:physiopathology; D001929:Brain Edema / Q000000981:diagnostic imaging / Q000503:physiopathology; D001930:Brain Injuries / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D006408:Hematoma, Subdural / Q000000981:diagnostic imaging / Q000503:physiopathology; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D006985:Hyperventilation / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D012121:Respiration, Artificial; D017585:Ultrasonography, Doppler, Transcranial
D002245:Carbon Dioxide