Effects of neuroleptic medications on the cognition of patients with schizophrenia: a review of recent studies.
In this review, we have examined the effects of neuroleptic medications on neurocognitive functions in articles published since 1990. Based on recent work and reviews of older studies, neuroleptics do not appear to have marked positive or negative effects on working memory or secondary memory. In contrast, neuroleptic medications appear to have a salutary effect on sustained vigilance or response readiness. The relationship or lack thereof between changes in cognition and changes in clinical state (produced by neuroleptics) is also discussed.
Goldberg
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Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Washington, D.C. 20032, USA.
Weinberger
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D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001288:Attention / Q000187:drug effects; D003024:Clozapine / Q000494:pharmacology / Q000627:therapeutic use; D003071:Cognition / Q000187:drug effects*; D006801:Humans; D007360:Intelligence / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D009048:Motor Skills / Q000187:drug effects; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D014888:Wechsler Scales
D014150:Antipsychotic Agents; D003024:Clozapine