title: Induction of macrophage antiprotozoal activity by monocyte chemotactic and activating factor.
abstract: To determine if monocyte chemotactic and activating factor (MCAF) induces intracellular antimicrobial activity, human monocyte-derived macrophages were treated with MCAF and challenged with Toxoplasma gondii and Leishmania donovani. Pretreatment with MCAF induced macrophages to inhibit protozoal replication by approximately 50%. These findings suggest a potential host defense role for MCAF in the inflammatory response to intracellular pathogens.
authors.affiliation: Division of Infectious Diseases, Cornell University Medical College, New York, NY 10021, USA.
authors.forename: S B
authors.initials: SB
authors.lastname: Mannheimer
authors.forename: J
authors.initials: J
authors.lastname: Hariprashad
authors.forename: M Y
authors.initials: MY
authors.lastname: Stoeckle
authors.forename: H W
authors.initials: HW
authors.lastname: Murray
mesh_terms: D000818:Animals; D018932:Chemokine CCL2 / Q000494:pharmacology*; D006801:Humans; D007893:Leishmania donovani / Q000187:drug effects* / Q000254:growth & development; D007896:Leishmaniasis / Q000517:prevention & control*; D008264:Macrophages / Q000469:parasitology*; D014122:Toxoplasma / Q000187:drug effects* / Q000254:growth & development; D014123:Toxoplasmosis / Q000517:prevention & control*
chemical_list: D018932:Chemokine CCL2