title: The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans.
abstract: The Candida albicans HOG1 gene (HOG1CA) was cloned by functional complementation of the osmosensitive phenotype associated with Saccharomyces cerevisiae hog1 delta mutants. HOG1CA codes for a 377-amino-acid protein, 78% identical to S. cerevisiae Hog1p. A C. albicans hog1 null mutant was found to be sensitive to osmotic stress and failed to accumulate glycerol on high-osmolarity media.
authors.affiliation: Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: San José
authors.forename: R A
authors.initials: RA
authors.lastname: Monge
authors.forename: R
authors.initials: R
authors.lastname: Pérez-Díaz
authors.forename: J
authors.initials: J
authors.lastname: Pla
authors.forename: C
authors.initials: C
authors.lastname: Nombela
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000235:genetics*; D002176:Candida albicans / Q000235:genetics*; D003001:Cloning, Molecular; D005800:Genes, Fungal; D005816:Genetic Complementation Test; D005990:Glycerol / Q000378:metabolism*; D020928:Mitogen-Activated Protein Kinases; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D009997:Osmotic Pressure; D010641:Phenotype; D029701:Saccharomyces cerevisiae Proteins; D017422:Sequence Analysis, DNA; D015398:Signal Transduction / Q000235:genetics
chemical_list: D029701:Saccharomyces cerevisiae Proteins; D017871:Calcium-Calmodulin-Dependent Protein Kinases; C088589:HOG1 protein, S cerevisiae; D020928:Mitogen-Activated Protein Kinases; D005990:Glycerol