Amphotericin B resistant isolates of Cryptococcus neoformans without alteration in sterol biosynthesis.
Amphotericin B resistant mutants of Cryptococcus neoformans were isolated accumulating mainly ergosterol. Cross-resistance to azole antifungals was not observed. Together with previous data this indicates that at least three categories of amphotericin B resistance can arise: sterol mutants, amphotericin B and azole cross-resistant mutants and amphotericin B resistant mutants with no azole cross-resistance.
Joseph-Horne
T
T
Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, UK.
Loeffler
R S
RS
Hollomon
D W
DW
Kelly
S L
SL
D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D003455:Cryptococcus neoformans / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism*; D004352:Drug Resistance, Microbial; D013261:Sterols / Q000096:biosynthesis*
D000935:Antifungal Agents; D013261:Sterols; D000666:Amphotericin B