The impact of cocaine on plasma growth hormone levels in the adult male rat.
Little is known about the neuroendocrine impact of cocaine as it relates to pituitary growth hormone secretion. In these studies, in adult male rats, intracerebroventricular administration of cocaine caused a potent dose-related suppression of circulating growth hormone (GH) in animals sacrificed 15 min after drug administration. We conclude that in the adult male rat cocaine suppresses plasma GH levels.
Emanuele
N V
NV
Research Service, Department of Veterans Affairs Hospital, Hines, IL 60141, USA.
Levey
A D
AD
Li
Q
Q
Kirsteins
L
L
Van de Kar
L D
LD
D000818:Animals; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D013006:Growth Hormone / Q000097:blood*; D007700:Kinetics; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D013006:Growth Hormone; D003042:Cocaine