Diagnostic evaluation of the substantia nigra.
An improved method for the histopathological evaluation of the substantia nigra for diagnostic purposes is proposed. This method takes advantage of the natural architecture of the constituent cell clusters of the substantia nigra by combining standardized sections in the horizontal plane and simple quantification. The use of this standardized technique should increase the diagnostic reliability and sensitivity of patterns of cell loss within the substantia nigra.
McRitchie
D A
DA
Department of Pathology, University of Sydney, Australia.
Halliday
G M
GM
Pamphlett
R
R
D001933:Brain Stem / Q000033:anatomy & histology / Q000473:pathology; D006801:Humans; D010300:Parkinson Disease / Q000175:diagnosis* / Q000473:pathology; D010336:Pathology / Q000379:methods*; D013378:Substantia Nigra / Q000473:pathology*