title: Modulation of SERCA2 activity: regulated splicing and interaction with phospholamban.
abstract: Ca(2+)-uptake into intracellular stores is mediated by the sarco/endoplasmic reticulum Ca(2+)ATPases (SERCAs). This review deals first with the gene structural and the characterization of the tissue-specific SERCA2 transcript processing. Secondly, the two different protein isoforms and their regulation are described. Finally, this review ends with a discussion on the possible physiological role of the SERCA2 isoform diversity.
authors.affiliation: Laboratorium voor Fysiologie, KULeuven, Belgium.
authors.forename: H
authors.initials: H
authors.lastname: Verboomen
authors.forename: L
authors.initials: L
authors.lastname: Mertens
authors.forename: J
authors.initials: J
authors.lastname: Eggermont
authors.forename: F
authors.initials: F
authors.lastname: Wuytack
authors.forename: L
authors.initials: L
authors.lastname: Van Den Bosch
mesh_terms: D000818:Animals; D002135:Calcium-Binding Proteins / Q000502:physiology*; D000252:Calcium-Transporting ATPases / Q000502:physiology*; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D017136:Ion Transport; D012519:Sarcoplasmic Reticulum / Q000502:physiology*; D014158:Transcription, Genetic; D000099211:Phospholamban
chemical_list: D002135:Calcium-Binding Proteins; D000252:Calcium-Transporting ATPases; D000099211:Phospholamban