title: Wear-resistant, hemocompatible Ti-Nb-Zr and Zr-Nb alloys to improve blood pump design and performance.
abstract: Over the past several years, we have developed novel titanium-niobium-zirconium (Ti-Nb-Zr) alloys to address the long-term performance needs of orthopedic implants. The unique properties of these alloys also render them promising candidates for blood pumps. These properties include excellent biocompatibility in combination with high strength and toughness, and low elastic modulus (low stiffness). Additionally, these metal alloys are readily hot or cold worked into complex shapes including wire, foil, tubing and bar. They are readily machined and polished, and they can be surface oxidized to form a hard, wear-resistant, low-friction ceramic surface layer. In this diffusion-hardened condition, oxygen also hardens the underlying metal to optimize the bone between the ceramic oxide surface and the tough metal substrate. Unlike metal surfaces, oxidative wear, which can alter surface energy, friction, and hemocompatibility, does not occur. Consequently, the combined benefits of a stable, wear-resistant, low-friction ceramic surface layer with the toughness, strength, formability, and thermal conductivity of metal may provide improvements in the design and performance of blood pumps and peripheral graft and percutaneous (power) components of the pump.
authors.affiliation: Smith & Nephew Richards, Inc., Memphis, Tennessee, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Davidson
authors.forename: K P
authors.initials: KP
authors.lastname: Daigle
authors.forename: P
authors.initials: P
authors.lastname: Kovacs
mesh_terms: D000497:Alloys / Q000592:standards*; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D001792:Blood Platelets / Q000378:metabolism; D002448:Cell Adhesion / Q000502:physiology; D002516:Ceramics / Q000737:chemistry; D003362:Cost-Benefit Analysis; D004058:Diffusion; D004389:Durable Medical Equipment / Q000639:trends; D006353:Heart-Assist Devices / Q000009:adverse effects / Q000592:standards*; D006801:Humans; D009556:Niobium / Q000378:metabolism; D010084:Oxidation-Reduction; D014025:Titanium / Q000378:metabolism; D015040:Zirconium / Q000378:metabolism
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D009556:Niobium; D015040:Zirconium; D014025:Titanium