Human endopeptidase (THOP1) is localized on chromosome 19 within the linkage region for the late-onset alzheimer disease AD2 locus.
A cDNA encoding the rat endopeptidase 24.15 was used to determine the chromosomal localization of the respective human gene. Hybridization to DNA from human-rodent somatic cell hybrids assigned the human gene to chromosome 19. Fluorescence in situ hybridization on human metaphase chromosomes localized the human endopeptidase 24.15 to 19q13.3.
Meckelein
B
B
Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA.
de Silva
H A
HA
Roses
A D
AD
Rao
P N
PN
Pettenati
M J
MJ
Xu
P T
PT
Hodge
R
R
Glucksman
M J
MJ
Abraham
C R
CR
D000544:Alzheimer Disease / Q000235:genetics; D000818:Animals; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D010450:Endopeptidases / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D051381:Rats
D010450:Endopeptidases