title: Parietal bone non-secreting solitary myeloma (plasmacytoma) with spread to the epidural space and scalp. Case report.
abstract: A case of solitary osteolytic lesion in the parietal bone in an otherwise asymptomatic patient is reported. Skull radiographs showed a radio-lucent lesion with well-defined margins without sclerotic reaction, CT scan demonstrated a mass that markedly enhanced extending from the epidural to the subcutaneous space of the parietal region. The patient underwent surgery and tumor was completely excised. Pathological examination showed tumor to be a plasmacytoma synthesizing kappa chains. Postoperatively the patient received radiotherapy. Four years after treatment there was no sign of local recurrence on CT can and of progression of multiple myeloma on clinical and laboratory studies. Our recommended treatment is that of a complete surgical excision followed by radiation to dose levels of 45-50 Gy. The patients should be followed carefully because of either local recurrence or possible progression to multiple myeloma. Radiotherapy and chemotherapy should started when signs of progression or other significant disease manifestations occur.
authors.affiliation: Institute for Neurosurgery, University of Catania, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Zingale
authors.forename: G
authors.initials: G
authors.lastname: Magro
authors.forename: V
authors.initials: V
authors.lastname: Albanese
mesh_terms: D000368:Aged; D004824:Epidural Space / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000378:metabolism; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism; D009361:Neoplasm Invasiveness; D010294:Parietal Bone / Q000000981:diagnostic imaging* / Q000378:metabolism; D010954:Plasmacytoma / Q000000981:diagnostic imaging* / Q000378:metabolism; D012535:Scalp / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed
chemical_list: D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains