title: Enhanced levels of soluble VCAM-1 in sickle cell patients and their specific increment during vasoocclusive crisis.
abstract: Adhesion of sickle erythrocytes to vascular endothelium plays a central role in sickle cell disease complications. Cytokines and adhesion molecules are critically involved in the regulation of these adhesive processes. To analyze their role, IL-6, GM-CSF, sVCAM-1, sICAM-1, sE-Selectin, and sP-Selectin serum levels were determined in sickle cell patients under basic conditions and during vasoocclusive crisis. In nonsymptomatic patients a high serum level of sVCAM-1 was observed compared to controls. In patients having vasoocclusive crisis sVCAM-1 levels increased even more and seemed to correlate with crisis evolution.
authors.affiliation: Clinical Laboratory Department, St. Elisabeth Hospital, Red Cross Blood Bank Curaçao, Netherlands Antilles. aduits@ibm.net
authors.forename: A J
authors.initials: AJ
authors.lastname: Duits
authors.forename: R C
authors.initials: RC
authors.lastname: Pieters
authors.forename: A W
authors.initials: AW
authors.lastname: Saleh
authors.forename: E
authors.initials: E
authors.lastname: van Rosmalen
authors.forename: H
authors.initials: H
authors.lastname: Katerberg
authors.forename: K
authors.initials: K
authors.lastname: Berend
authors.forename: R A
authors.initials: RA
authors.lastname: Rojer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000276:immunology*; D016022:Case-Control Studies; D019040:E-Selectin / Q000097:blood; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood; D006450:Hemoglobin SC Disease / Q000097:blood / Q000276:immunology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D012995:Solubility; D013997:Time Factors; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
chemical_list: D019040:E-Selectin; D015850:Interleukin-6; D019007:P-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D016178:Granulocyte-Macrophage Colony-Stimulating Factor