Failure of prostatitis treatment secondary to probable ciprofloxacin-sucralfate drug interaction.
Metal cations such as aluminum, magnesium, ferrous sulfate, and zinc are thought to form chelation complexes with fluoroquinolone antibiotics and prevent the drugs from being absorbed. Sucralfate, which has a high aluminum content, reduces the bioavailability of ciprofloxacin to approximately 4%. The concomitant administration of ciprofloxacin and sucralfate resulted in treatment failure for a patient with prostatitis and a subsequent 5-day hospitalization. Fluoroquinolone antibiotics should be administered at least 2 hours before agents containing metal cations to allow for their absorption. In addition, sucralfate should not be administered less than 6 hours before fluoroquinolone antibiotic administration.
Spivey
J M
JM
Department of Family Medicine, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354, USA.
Cummings
D M
DM
Pierson
N R
NR
D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects*; D002939:Ciprofloxacin / Q000009:adverse effects*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005765:Gastrointestinal Agents / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011472:Prostatitis / Q000188:drug therapy*; D013290:Streptococcal Infections / Q000188:drug therapy; D013392:Sucralfate / Q000009:adverse effects*
D000890:Anti-Infective Agents; D005765:Gastrointestinal Agents; D013392:Sucralfate; D002939:Ciprofloxacin