title: Neuroleptic malignant syndrome in a patient with head injury.
abstract: Neuroleptic malignant syndrome is an idiosyncratic reaction associated with the use of neuroleptic drugs. We report a case of this rare syndrome in a head injury patient associated with some unusual features: rhabdomyolysis with a high level of creatine kinase, the development of acute renal failure, the early use of continuous venovenous haemofiltration in treatment and rigidity that was refractory to conventional treatment with dantrolene and bromocriptine. The diagnosis in patients with multiple injuries must be based on a high index of suspicion.
authors.affiliation: Intensive Care Medicine Department, University Hospital 12 Octubre, Madrid, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Perez-Vela
authors.forename: M
authors.initials: M
authors.lastname: Sanchez Casado
authors.forename: J A
authors.initials: JA
authors.lastname: Sanchez-Izquierdo Riera
authors.forename: A
authors.initials: A
authors.lastname: Ambros Checa
authors.forename: R
authors.initials: R
authors.lastname: Caballero Cubedo
authors.forename: E
authors.initials: E
authors.lastname: Alted Lopez
mesh_terms: D000293:Adolescent; D001971:Bromocriptine / Q000627:therapeutic use; D006259:Craniocerebral Trauma / Q000150:complications*; D003402:Creatine Kinase / Q000097:blood; D003620:Dantrolene / Q000627:therapeutic use; D006440:Hemofiltration; D006801:Humans; D008297:Male; D009104:Multiple Trauma / Q000150:complications; D009459:Neuroleptic Malignant Syndrome / Q000209:etiology* / Q000628:therapy; D010197:Pancuronium / Q000627:therapeutic use; D012206:Rhabdomyolysis / Q000150:complications
chemical_list: D001971:Bromocriptine; D003402:Creatine Kinase; D003620:Dantrolene; D010197:Pancuronium