HLA-B27 subtypes in Japanese with seronegative spondyloarthropathies and healthy controls.
OBJECTIVE
To determine HLA-B27 subtype frequencies in Japanese patients with seronegative spondyloarthropathies (SpA) and healthy controls.


METHODS
We determined HLA-B27 subtypes of 20 Japanese patients with ankylosing spondylitis and one with Reiter's syndrome, and 11 healthy Japanese individuals using a polymerase chain reaction sequence specific oligonucleotide hybridization method specifically designed for the discrimination of B*2701-09.


RESULTS
14 of 21 (67%) patients and 9 of 11 (82%) controls were typed as B*2704. The remainder were B*2705.


CONCLUSIONS
HLA-B*2704 and B*2705 are present in the Japanese population, the former being the predominant subtype of HLA-B27. Both subtypes are associated with SpA.
Yamaguchi
A
A
Department of Internal Medicine and Physical Therapy, Faculty of Medicine University of Tokyo, Japan.
Ogawa
A
A
Tsuchiya
N
N
Shiota
M
M
Mitsui
H
H
Tokunaga
K
K
Tadokoro
K
K
Juji
T
T
Ito
K
K
D044466:Asian People; D001483:Base Sequence; D016384:Consensus Sequence; D015796:HLA-B27 Antigen / Q000032:analysis* / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D015151:Immunoblotting; D007564:Japan; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D017422:Sequence Analysis, DNA; D013167:Spondylitis, Ankylosing / Q000097:blood / Q000276:immunology*
D015796:HLA-B27 Antigen