A cationic polymer, Eudragit-E, as a new liquid embolic material for arteriovenous malformations.
We have developed a new liquid material for embolisation of arteriovenous malformations: a mixture of methyl and butyl methacrylate, plus dimethylaminoethyl methacrylate copolymer (Eudragit-E) in a solvent consisting of ethanol and iopamidol. Upon contact with aqueous substances, Eudragit-E precipitates rapidly and forms a soft elastic sponge within 3 s, as the ethanol diffuses. In blood, the positively charged Eudragit-E aggregates the negatively charged blood elements. Transcatheter embolisation of 4 canine and 52 rat renal arteries was feasible. Histological studies revealed no acute inflammatory reaction within 1 week, but mild to moderate reactions in the subacute and chronic stages. No recanalisation was seen. Because of its unique properties and excellent thrombogenicity the Eudragit-E, mixture seems a promising embolic material.
Yamashita
K
K
Department of Neurosurgery, Faculty of Medicine, Kyoto University, Japan.
Taki
W
W
Iwata
H
H
Kikuchi
H
H
D000704:Analysis of Variance; D000818:Animals; D001165:Arteriovenous Malformations / Q000628:therapy; D001672:Biocompatible Materials; D002406:Catheterization, Peripheral / Q000379:methods; D004285:Dogs; D004621:Embolization, Therapeutic / Q000379:methods*; D004730:Endothelium, Vascular / Q000187:drug effects; D005500:Follow-Up Studies; D007249:Inflammation / Q000209:etiology; D007261:Infusions, Intra-Arterial; D008422:Materials Testing; D008689:Methacrylates / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry; D008768:Methylmethacrylates; D011859:Radiography; D051381:Rats; D017208:Rats, Wistar; D012077:Renal Artery / Q000000981:diagnostic imaging; D014783:Viscosity
D001672:Biocompatible Materials; D008689:Methacrylates; D008768:Methylmethacrylates; C102808:Eudragit-E