title: Differences between 99mTc-DTPA and 99mTc-MAG3 captopril renographies in renovascular hypertension.
abstract: Captopril renography (CRS) with 99mTc-DTPA and 99mTc-MAG3 was performed on a 21-year-old woman with renovascular hypertension due to right renal artery stenosis caused by fibromuscular dysplasia. In the affected kidney, the renogram pattern was substantially changed with 99mTc-DTPA and 99mTc-MAG3 following the administration of captopril, and the quantitated renal uptake indicating individual renal function was significantly decreased in 99mTc-DTPA and slightly decreased in 99mTc-MAG3. In the contralateral normal kidney, the renogram showed some minor changes with both radioagents, while the quantitated renal uptake was significantly decreased with 99mTc-DTPA and substantially increased with 99mTc-MAG3. The combined use of physiologically different renal agents 99mTc-DTPA and 99mTc-MAG3 is helpful in investigating hemodynamic and functional changes in the stenosed kidney as well as the normal kidney in RVH.
authors.affiliation: Department of Nuclear Medicine, Hokkaido University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Itoh
authors.forename: Y
authors.initials: Y
authors.lastname: Matsui
authors.forename: C
authors.initials: C
authors.lastname: Kato
authors.forename: T
authors.initials: T
authors.lastname: Mochizuki
authors.forename: A
authors.initials: A
authors.lastname: Kitabatake
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood; D002216:Captopril; D005260:Female; D006801:Humans; D006978:Hypertension, Renovascular / Q000000981:diagnostic imaging*; D007668:Kidney / Q000000981:diagnostic imaging*; D009638:Norepinephrine / Q000097:blood; D011859:Radiography; D011877:Radionuclide Imaging; D012077:Renal Artery / Q000000981:diagnostic imaging; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging; D012083:Renin / Q000097:blood; D017263:Technetium Tc 99m Mertiatide; D016284:Technetium Tc 99m Pentetate; D013997:Time Factors
chemical_list: D017263:Technetium Tc 99m Mertiatide; D000450:Aldosterone; D002216:Captopril; D012083:Renin; D016284:Technetium Tc 99m Pentetate; D009638:Norepinephrine