Amphotericin B lipid complex treatment of a leukemic child with disseminated Fusarium solani infection.
We report a case of Fusarium solani infection in a 2 1/2-year-old girl with acute lymphoblastic leukemia and severe neutropenia. The infection, initially limited to her sinuses, became disseminated, as evidenced by the development of a characteristic cutaneous lesion on her left leg after a cumulative dose of amphotericin B of 18.3 mg/kg. Amphotericin B lipid complex (ABLC), 5 mg/kg/day, in conjunction with repeated surgical debridement of the sinuses and correction of neutropenia with granulocyte colony stimulating factor (GCSF), led to clinical and mycologic cure.
Patterson
T S
TS
Department of Pediatrics, University of Arizona, Tucson 85724, USA.
Barton
L L
LL
Shehab
Z M
ZM
Hutter
J J
JJ
D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D003881:Dermatomycoses / Q000188:drug therapy / Q000382:microbiology; D004338:Drug Combinations; D004352:Drug Resistance, Microbial; D005260:Female; D005670:Fusarium / Q000187:drug effects; D006801:Humans; D016867:Immunocompromised Host; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology; D009503:Neutropenia / Q000150:complications; D010254:Paranasal Sinus Diseases / Q000188:drug therapy* / Q000382:microbiology; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D010715:Phosphatidylglycerols / Q000627:therapeutic use*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*
D000935:Antifungal Agents; D004338:Drug Combinations; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; C068538:liposomal amphotericin B; D000666:Amphotericin B