Directed TOCSY, a method for selection of directed correlations by optimal combinations of isotropic and longitudinal mixing.
The directed TOCSY pulse sequence element transfers coherence predominantly into "forward-directed" antiphase coherences while simultaneously suppressing in-phase and "backward-directed" antiphase coherences. This novel selection principle, based on the "direction" of the target coherences, provides a new approach for the simplification of crowded spectra. In this article, the theory of directed TOCSY is presented for linear spin systems that are frequently found in carbon-labeled biomolecules.
Glaser
S J
SJ
Institut für Organische Chemie, Universität Frankfurt, Marie-Curie-Strasse 11, Frankfurt, D-60439, Germany.
Schwalbe
H
H
Marino
J P
JP
Griesinger
C
C
D008279:Magnetic Resonance Imaging / Q000379:methods*; D008433:Mathematics; D009841:Oligonucleotides / Q000032:analysis; D012313:RNA / Q000032:analysis
D009841:Oligonucleotides; D012313:RNA