Cardioactive compounds from Eremophila species.
The isolation and identification of two cardioactive compounds from two Eremophila species (Myoporaceae) considered important in the pharmacopoeia of the Australian Aboriginal people is described. Verbascoside, isolated from the methanol and water extracts of E. alternifolia leaves, mediated significant increases in chronotropism, inotropism and coronary perfusion rate (CPR) in the Langendorff rat heart. Geniposidic acid, isolated from the methanol extract of E. longifolia leaves, mediated an inhibitory effect with significant negative chronotropism, negative inotropism and CPR.
Pennacchio
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M
School of Environmental Biology, Curtin University of Technology, Perth, Australia.
Syah
Y M
YM
Ghisalberti
E L
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Alexander
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E
D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification* / Q000494:pharmacology; D001315:Australia; D003326:Coronary Circulation / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D005960:Glucosides / Q000302:isolation & purification* / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D057888:Iridoid Glucosides; D039823:Iridoids; D008519:Medicine, Traditional; D000432:Methanol / Q000737:chemistry; D009200:Myocardial Contraction / Q000187:drug effects*; D010636:Phenols; D010936:Plant Extracts / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves / Q000378:metabolism; D011714:Pyrans / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D059808:Polyphenols
D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D057888:Iridoid Glucosides; D039823:Iridoids; D000432:Methanol; D010636:Phenols; D010936:Plant Extracts; D011714:Pyrans; C058966:geniposidic acid; C058956:acteoside; D059808:Polyphenols