title: Could somatostatin scintigraphy be superior to MIBG scan in the staging of stage IVs neuroblastoma (Pepper's syndrome)?
abstract: A 4-month-old infant suffering from Stage IVs neuroblastoma (NB IVs; Pepper's syndrome) was repeatedly examined by I-123 MIBG and somatostatin analog in-111 pentetreotide (SMS) scintigraphy, during a 2-year period. Treatment was restricted to surgery of the primary tumor. I-123 MIBG and SMS scan results were positive in the primary tumor and liver, but I-123 MIBG yielded very poor images and failed to reliably detect bone marrow metastases in the lower limbs and skull, whereas SMS precisely visualized these lesions. Six months after diagnosis, the infant was in complete clinical remission. I-123 MIBG and SMS images had returned to normal at 1 year. The prognostic implication of positive SMS imaging, in combination with positive or negative I-123 MIBG scan results, is not known in NB IVs and requires further investigation.
authors.affiliation: Department of Nuclear Medicine, Institut Curie, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Manil
authors.forename: V
authors.initials: V
authors.lastname: Edeline
authors.forename: J
authors.initials: J
authors.lastname: Michon
authors.forename: S
authors.initials: S
authors.lastname: Neuenschwander
authors.forename: H
authors.initials: H
authors.lastname: Lequen
authors.forename: C
authors.initials: C
authors.lastname: Lavocat
authors.forename: J M
authors.initials: JM
authors.lastname: Zucker
mesh_terms: D019797:3-Iodobenzylguanidine; D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D019046:Bone Marrow Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D005500:Follow-Up Studies; D006801:Humans; D007205:Indium Radioisotopes; D007223:Infant; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000556:secondary; D011877:Radionuclide Imaging; D013004:Somatostatin / Q000031:analogs & derivatives*; D013577:Syndrome
chemical_list: D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine; D013004:Somatostatin; C081788:pentetreotide