Improved stereospecific synthesis of novel 1-alkyl-3-benzoyl-4-hydroxy-4-phenylpiperidines.
The stereoselective synthesis of conformationally restricted 1-alkyl-3-benzoyl-4-hydroxy-4-phenylpiperidine hydrochlorides via the Mannich reaction followed by an intramolecular aldol condensation is reported. The compounds were evaluated by 1H NMR and 13C NMR techniques.
Jaffar
M
M
School of Pharmacy and Pharmacology, University of Bath, UK.
Upton
C
C
D006633:Histamine Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008352:Mannich Bases / Q000737:chemistry; D008968:Molecular Conformation; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology; D013237:Stereoisomerism
D006633:Histamine Antagonists; D008352:Mannich Bases; D010880:Piperidines