The mouse mutation sarcosinemia (sar) maps to chromosome 2 in a region homologous to human 9q33-q34.
The autosomal recessive mouse mutation sarcosinemia (sar), which was discovered segregating in the progeny of a male whose premeiotic germ cells had been treated with the mutagen ethylnitrosourea, is characterized by a deficiency in sarcosine dehydrogenase activity. Using an intersubspecific cross, we mapped the sar locus to mouse chromosome 2, approximately 15-18 cM from the centromere. The genetic localization of this locus in the mouse allows the identification of a candidate region in human (9q33-q34) where the homologous disease should map.
Brunialti
A L
AL
Institut Pasteur à Paris, 25 rue du Docteur Roux, Paris Cedex 15, 75724, France.
Harding
C O
CO
Wolff
J A
JA
Guénet
J L
JL
D000592:Amino Acid Metabolism, Inborn Errors / Q000235:genetics*; D000818:Animals; D002503:Centromere / Q000235:genetics; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D005260:Female; D005808:Genes, Recessive / Q000235:genetics; D006801:Humans; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D018895:Microsatellite Repeats; D009154:Mutation; D011110:Polymorphism, Genetic; D012521:Sarcosine / Q000097:blood / Q000378:metabolism*
D012521:Sarcosine