title: Cyclic nucleotide-gated ion channels: an extended family with diverse functions.
abstract: An ion channel directly activated by cGMP was first discovered about ten years ago. Since then, a number of ion channels with the same property (cyclic nucleotide-activated channels) have been reported that are involved in a variety of cell functions. In addition, other channels have been found that are not primarily controlled by cyclic nucleotides but are modulated by them (cyclic nucleotide-modulated channels). These channels likewise have diverse functions and tissue distributions. Both channel classes are reviewed here. Coverage includes the cyclic-nucleotide binding site on these channels, ion permeation, pharmacological blockers, channel gating and modulation, and physiological functions of the channels.
authors.affiliation: Thomas C. Jenkins Department of Biophysics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
authors.forename: J T
authors.initials: JT
authors.lastname: Finn
authors.forename: M E
authors.initials: ME
authors.lastname: Grunwald
authors.forename: K W
authors.initials: KW
authors.lastname: Yau
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000242:Cyclic AMP / Q000502:physiology*; D006152:Cyclic GMP / Q000502:physiology*; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology*; D008969:Molecular Sequence Data
chemical_list: D007473:Ion Channels; D000242:Cyclic AMP; D006152:Cyclic GMP