Monocyte chemoattractant protein 1: a potential regulator of monocyte recruitment in inflammatory disease.
The appearance of specific types of leukocytes in inflammatory infiltrates may be governed by cell-specific chemoattractants called chemokines. In particular, monocyte chemoattractant protein 1 (MCP-1) has been implicated in diseases characterized by monocyte-rich infiltrates, including atherosclerosis, rheumatoid arthritis and multiple sclerosis. While we are beginning to understand the structural determinants that govern the activities of MCP-1 in vitro, we know much less about its physiological functions in vivo and its pathogenetic role in disease. However, recent data from genetically modified mice have begun to place MCP-1 in a central position in monocyte trafficking and activation.
Rollins
B J
BJ
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. barrett-rollins@macmailgw.dfci.harvard.edu
D000595:Amino Acid Sequence; D000818:Animals; D018932:Chemokine CCL2 / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D051379:Mice; D008969:Molecular Sequence Data; D009000:Monocytes / Q000276:immunology*; D013329:Structure-Activity Relationship
D018932:Chemokine CCL2