Fibroblasts from Li-Fraumeni patients are resistant to low dose-rate irradiation.
A group of adult skin fibroblast cultures from four individuals representing Li-Fraumeni families with different mutations in the p53 gene were found to be resistant to low dose-rate (0.011 Gy per min) 60Co radiation when compared with a control group of four cultures from normal individuals. The Li-Fraumeni fibroblasts, which could not be distinguished from controls after high dose rate (1.07 Gy per min) irradiation, were shown to be heterozygous (+/mut) at the p53 locus at the time of irradiation.
Sproston
A R
AR
CRC Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Manchester, UK.
Boyle
J M
JM
Heighway
J
J
Birch
J M
JM
Scott
D
D
D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D002675:Child, Preschool; D005260:Female; D005347:Fibroblasts / Q000528:radiation effects; D016158:Genes, p53; D006801:Humans; D016864:Li-Fraumeni Syndrome / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011836:Radiation Tolerance