New p-quinonoid aporphine alkaloids and antiplatelet aggregation constituents of Hernandia sonora.
Three minor new p-quinonoid aporphine alkaloids, sonodione (1), demethylsonodione (2), and norsonodione (3), have been additionally isolated from the stem bark of Hernandia sonora. The structures of these compounds were elucidated by spectral analysis. Among the isolates obtained till now, five compounds, ovigerine (4), hernangerine (5), N-methylhernangerine (6), (+)-malekulatine (7), and isovanillin (8) showed moderate antiplatelet aggregation activity in vitro.
Chen
I S
IS
Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan, Republic of China.
Chen
J J
JJ
Tsai
I L
IL
Chang
Y L
YL
Teng
C M
CM
D000818:Animals; D001060:Aporphines / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D010944:Plants / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D016339:Spectrometry, Mass, Fast Atom Bombardment
D001060:Aporphines; D010975:Platelet Aggregation Inhibitors; C101975:demethylsonodione; C101976:norsonodione; C101974:sonodione