Poliovirus: new insights from an old paradigm.
A combination of structural and genetic studies of poliovirus suggests that the final stages of viral assembly lock the virus in a metastable structure primed to undergo the receptor-catalyzed conformational changes required for cell entry. Future studies promise to provide detailed insights into the conformational dynamics of the virion during its life cycle.
Wien
M W
MW
Committee for Higher Degrees in Biophysics, Harvard University, Cambridge, MA 02138, USA.
Chow
M
M
Hogle
J M
JM
D008565:Membrane Proteins; D008958:Models, Molecular; D015394:Molecular Structure; D017955:Poliovirus / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D012367:RNA, Viral / Q000235:genetics; D011991:Receptors, Virus / Q000502:physiology; D013329:Structure-Activity Relationship
D008565:Membrane Proteins; D012367:RNA, Viral; D011991:Receptors, Virus; C066100:poliovirus receptor