The ubiquitin-mediated proteolytic system: involvement of molecular chaperones, degradation of oncoproteins, and activation of transcriptional regulators.
Ciechanover
A
A
The Department of Biochemistry, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
Laszlo
A
A
Bercovich
B
B
Stancovski
I
I
Alkalay
I
I
Ben-Neriah
Y
Y
Orian
A
A
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism*; D050883:HSC70 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D020672:I-kappa B Proteins; D066298:In Vitro Techniques; D008954:Models, Biological; D018832:Molecular Chaperones / Q000378:metabolism*; D000072000:NF-KappaB Inhibitor alpha; D016328:NF-kappa B / Q000378:metabolism; D015513:Oncogene Proteins / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism; D011817:Rabbits; D012156:Reticulocytes / Q000378:metabolism; D015533:Transcriptional Activation; D014452:Ubiquitins / Q000378:metabolism*
D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D050883:HSC70 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D020672:I-kappa B Proteins; D018832:Molecular Chaperones; D016328:NF-kappa B; D015513:Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; D014452:Ubiquitins; D000072000:NF-KappaB Inhibitor alpha; D010450:Endopeptidases