title: Hepatic epoxide concentrations during biotransformation of 1,2- and 1,4-dichlorobenzene: the use of in vitro and in vivo metabolism, kinetics and PB-PK modeling.
authors.affiliation: TNO Toxicology, Zeist, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: Hissink
authors.forename: B
authors.initials: B
authors.lastname: van Ommen
authors.forename: J J
authors.initials: JJ
authors.lastname: Bogaards
authors.forename: P J
authors.initials: PJ
authors.lastname: van Bladeren
mesh_terms: D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000493:pharmacokinetics* / Q000633:toxicity; D002722:Chlorobenzenes / Q000493:pharmacokinetics* / Q000633:toxicity; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004852:Epoxy Compounds / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D008954:Models, Biological; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002273:Carcinogens; D002722:Chlorobenzenes; D004852:Epoxy Compounds; C004726:2-dichlorobenzene; D003577:Cytochrome P-450 Enzyme System; C018511:4-dichlorobenzene