title: A feasibility study of screening for endometrial carcinoma in postmenopausal women by ultrasonography.
abstract: BACKGROUND
  Abnormal endometrial thickness assessed by ultrasonography has been reported as a reliable indicator for early asymptomatic endometrial carcinoma.
  
  
  METHODS
  We evaluated the feasibility and the performance of screening by ultrasonography in a consecutive series of postmenopausal volunteers.
  
  
  RESULTS
  A total of 2,025 women were screened, and 117 (5.8%) showed abnormal endometrial thickness. Ninety-eight subjects consented to be assessed by outpatient endometrial biopsy, which was not possible in 32 for cervical stenosis. Three cancers were detected among 66 assessed subjects, 34 not-assessed subjects were controlled by repeat sonography (no change), and 17 were lost to follow-up. No other cancer was recorded by the local Cancer Registry among screened subjects. The prevalence/incidence ratio was 2.65:1, and the cost per screen-detected cancer was 18,571,000 Italian lire.
  
  
  CONCLUSIONS
  Screening by endometrial sonography is feasible on a practical basis, but its efficacy needs to be proven by prospective controlled studies which would enroll large populations to ensure sufficient statistical power, considering the low incidence and the low lethality of the disease. Studies of screening for other carcinomas may be considered of higher priority.
authors.affiliation: Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Ciatto
authors.forename: S
authors.initials: S
authors.lastname: Cecchini
authors.forename: R
authors.initials: R
authors.lastname: Bonardi
authors.forename: G
authors.initials: G
authors.lastname: Grazzini
authors.forename: A
authors.initials: A
authors.lastname: Mazzotta
authors.forename: M
authors.initials: M
authors.lastname: Zappa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016889:Endometrial Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000517:prevention & control*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D010349:Patient Compliance; D017698:Postmenopause; D011237:Predictive Value of Tests; D015995:Prevalence; D011446:Prospective Studies; D014463:Ultrasonography / Q000295:instrumentation / Q000379:methods; D014621:Vagina