title: A non-specific defence inducer in preventing clinical signs of infectious bovine rhinotracheitis in calves.
abstract: One calf was infected with bovine herpesvirus-1 (BHV-1) and mixed with five other calves, of which one had been vaccinated with a BHV-1 modified live vaccine one month earlier. The other four calves were vaccinated at the time the experimentally infected calf developed the first signs of the disease (fever, depression, nasal discharge), i.e. on post infection day (PID) 2. In addition to the vaccine, two of the four PID 2 vaccinated calves also received a non-specific defence (NSD) inducer (Baypamun, Bayer AG) at the same time as the vaccine. The calf that was vaccinated 1 month before the start of the experiment, as expected, did not show any signs of the disease. Of the remaining four, the two vaccine-only calves experienced a classical form of infectious bovine rhinotracheitis. However, the two calves that had also received the NSD inducer remained generally healthy during the entire observation period of 30 days. It was speculated that the use of a NSD inducer once an outbreak of a respiratory disease has started on a farm could be of significant help in an emergency in reducing the clinical manifestations in those animals that may subsequently be infected.
authors.affiliation: Istituto di Malattie Infettive, Università di Perugia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Castrucci
authors.forename: M
authors.initials: M
authors.lastname: Ferrari
authors.forename: B I
authors.initials: BI
authors.lastname: Osburn
authors.forename: F
authors.initials: F
authors.lastname: Frigeri
authors.forename: F
authors.initials: F
authors.lastname: Barreca
authors.forename: S
authors.initials: S
authors.lastname: Tagliati
authors.forename: V
authors.initials: V
authors.lastname: Cuteri
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D002417:Cattle; D007242:Herpesvirus 1, Bovine / Q000276:immunology*; D007241:Infectious Bovine Rhinotracheitis / Q000150:complications / Q000517:prevention & control*; D013997:Time Factors; D014613:Vaccines, Attenuated; D014765:Viral Vaccines / Q000008:administration & dosage*; D017201:Virus Shedding
chemical_list: D000276:Adjuvants, Immunologic; C076692:Baypamun HK; D014613:Vaccines, Attenuated; D014765:Viral Vaccines