title: cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region.
abstract: cDNA clones corresponding to the HKE4 and HKE6 genes at the centromeric end of the HLA region on human chromosome 6p21.3 were isolated and characterized. The predicted amino acid sequences of HKE4 and HKE6 exhibited 81.5 and 85.6% identity to the mouse homologues, Ke4 and Ke6, respectively. HKE4 may encode a membrane protein with histidine-rich charge clusters. HKE6 possesses remarkable amino acid sequence conservation with several bacterial proteins with oxidoreductase function and also shows significant homology with the two unique functional domains containing the nucleotide cofactor binding site and the consensus motif characteristic of the members of the superfamily of short-chain alcohol dehydrogenases such as human and rat steroid and prostaglandin dehydrogenases.
authors.affiliation: Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Ando
authors.forename: Y Y
authors.initials: YY
authors.lastname: Kikuti
authors.forename: A
authors.initials: A
authors.lastname: Shigenari
authors.forename: H
authors.initials: H
authors.lastname: Kawata
authors.forename: N
authors.initials: N
authors.lastname: Okamoto
authors.forename: T
authors.initials: T
authors.lastname: Shiina
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.forename: T
authors.initials: T
authors.lastname: Ikemura
authors.forename: K
authors.initials: K
authors.lastname: Abe
authors.forename: M
authors.initials: M
authors.lastname: Kimura
authors.forename: H
authors.initials: H
authors.lastname: Inoko
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D027682:Cation Transport Proteins; D002460:Cell Line; D002503:Centromere; D002896:Chromosomes, Human, Pair 6; D003001:Cloning, Molecular; D018076:DNA, Complementary; D018628:Gene Dosage; D006680:HLA Antigens / Q000235:genetics*; D006649:Histocompatibility Antigens / Q000235:genetics; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D010088:Oxidoreductases; D011506:Proteins / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
chemical_list: D027682:Cation Transport Proteins; D018076:DNA, Complementary; C079876:H2-Ke6 protein, mouse; D006680:HLA Antigens; C102228:HSD17B8 protein, human; D006649:Histocompatibility Antigens; D008565:Membrane Proteins; D011506:Proteins; C102227:SLC39A7 protein, human; D010088:Oxidoreductases