title: Electrical stimulation of cerebellar fastigial nucleus fails to rematch blood flow and metabolism in focal ischemic infarctions.
abstract: Electrical stimulation of the cerebellar fastigial nucleus (FN) in rat (1 h) reduces, by 50%, the infarction produced by occlusion of the middle cerebral artery (MCAO). We investigated whether salvage was associated with elevations in regional cerebral blood flow (rCBF) and/or reductions of regional cerebral glucose utilization (rCGU) in the retrievable zone (RZ). rCGU and rCBF were measured autoradiographically 1 h after MCAO. MCAO reduced rCBF to < 15% in the irretrievable zone (IZ) and approximately 50% in the RZ (P < 0.01 for each) while FN stimulation alone globally elevated rCBF by approximately 60% (P < 0.01). rCGU was not changed. After MCAO, FN stimulation failed to increase the reduced rCBF but elevated rCGU globally (to approximately 30%). Reductions of focal ischemic infarctions by stimulating FN cannot be attributed to changes in rCBF and or rCGU.
authors.affiliation: Department of Neurology and Neuroscience, Cornell University Medical College, New York, NY 10021, USA.
authors.forename: E V
authors.initials: EV
authors.lastname: Golanov
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
authors.forename: D J
authors.initials: DJ
authors.lastname: Reis
mesh_terms: D000818:Animals; D001345:Autoradiography; D001923:Brain Chemistry / Q000502:physiology*; D002545:Brain Ischemia / Q000503:physiopathology*; D002529:Cerebellar Nuclei / Q000502:physiology*; D002536:Cerebral Arteries / Q000502:physiology; D002544:Cerebral Infarction / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004558:Electric Stimulation; D005947:Glucose / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR
chemical_list: D005947:Glucose