title: New insights into lung growth and development.
abstract: Lung development requires a complex series of developmentally controlled interactions that involve mechanical forces, genetic and endocrine influences, and cell-cell communication. At each step, cell-matrix or cell-cell signaling mediated by peptide growth factors and extracellular matrix components is crucial in directing cell proliferation, differentiation, and migration. Although a comprehensive understanding of how these components interact to guide lung organogenesis has been elusive, the action and control of peptide growth factors in autocrine and paracrine signaling, mesenchymal-epithelial interactions in controlling branching morphogenesis, cell-cell communication in the regulation of cellular differentiation, and factors regulating pattern formation are being clarified.
authors.affiliation: Department of Pediatrics, University of North Carolina at Chapel Hill 27599, USA.
authors.forename: W A
authors.initials: WA
authors.lastname: Price
authors.forename: A D
authors.initials: AD
authors.lastname: Stiles
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D006133:Growth Substances / Q000235:genetics / Q000502:physiology; D006801:Humans; D008168:Lung / Q000196:embryology*; D008648:Mesoderm / Q000502:physiology; D009024:Morphogenesis / Q000502:physiology
chemical_list: D006133:Growth Substances