How do Ca2+ ions pass through the sarcoplasmic reticulum membrane.
We propose an overview of the mechanism of Ca2+ transport through the sarcoplasmic reticulum membrane via the Ca(2+)-ATPase. We describe cytoplasmic calcium binding, calcium occlusion in the membrane and lumenal calcium dissociation. A channel-like structure is discussed and related to structural data on the membranous domain of the Ca(2+)-ATPase.
Mintz
E
E
Unité de Recherche 1290 Associée au Centre National de la Recherche Scientifique, Gif-sur-Yvette, France.
Guillain
F
F
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D006801:Humans; D017136:Ion Transport; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*
D015220:Calcium Channels; D000252:Calcium-Transporting ATPases; D002118:Calcium