HLA-DPB1 polymorphism in seven South American Indian tribes in Colombia.
HLA-DPB1 allele frequencies were investigated in seven geographically and linguistically distinct Amerindian tribes of Colombia. Allele *1301 was found only in the Embera tribe living along the Pacific coast, while allele *0101 was found only in two individuals of the Wayuu tribe inhabiting the Guajira desert. Significant geographical variation was observed in the other two alleles (*1401 and *0402), which were found in all seven tribal groups. The possible reasons for this restricted polymorphism and the genetic diversity found in the investigation are discussed.
Briceno
I
I
Department of Human Genetics, University of Newcastle upon Tyne, UK.
Gomez
A
A
Bernal
J E
JE
Papiha
S S
SS
D000483:Alleles; D003105:Colombia; D005006:Ethnicity; D006682:HLA-DP Antigens / Q000235:genetics*; D059868:HLA-DP beta-Chains; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D011110:Polymorphism, Genetic
D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen