Kanchanamycins, new polyol macrolide antibiotics produced by Streptomyces olivaceus Tü 4018. I. Taxonomy, fermentation, isolation and biological activities.
The kanchanamycins, a group of novel 36-membered polyol macrolide antibiotics were detected in the culture filtrate and mycelium of Streptomyces olivaceus Tü 4018 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. The compounds show antibacterial and antifungal activities, and are especially effective against Pseudomonas fluorescens. Besides the kanchanamycin complex, strain Tü 4018 produces the 42-membered macrolactones, oasomycin A and desertomycin A, as well as tryptophan-dehydrobutyrine diketopiperazine and daidzein.
Fiedler
H P
HP
Biologisches Institut, Universität Tübingen, Germany.
Nega
M
M
Pfefferle
C
C
Groth
I
I
Kempter
C
C
Stephan
H
H
Metzger
J W
JW
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D007783:Lactones / Q000302:isolation & purification / Q000494:pharmacology; D018942:Macrolides; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D007783:Lactones; D018942:Macrolides; C101773:kanchanamycin A; C101774:kanchanamycin C; C101775:kanchanamycin D