title: Suppression of systemic lupus erythematosus by the human immunodeficiency virus.
abstract: We describe a patient with refractory systemic lupus erythematosus (SLE) who demonstrated complete resolution of all SLE symptoms. He was subsequently found to be infected with the human immunodeficiency virus (HIV-1) and had marked depletion of peripheral CD4 positive T lymphocytes. In addition, while his SLE remained completely inactive, the course of HIV was rapidly progressive, suggesting that retroviral replication may have been enhanced by the underlying state of T cell transactivation characteristic of SLE.
authors.affiliation: Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
authors.forename: V M
authors.initials: VM
authors.lastname: Byrd
authors.forename: J S
authors.initials: JS
authors.lastname: Sergent
mesh_terms: D000328:Adult; D018450:Disease Progression; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000821:virology*; D008297:Male; D013601:T-Lymphocytes / Q000502:physiology / Q000821:virology