Lymphoid involvement in a patient with acute myeloid leukemia: a direct phenotypic and genotypic study of single cells.
Lymphoid involvement in acute myeloid leukemia (AML) was studied using the morphology-antibody-chromosome (MAC) combination technique in one patient. The chromosomal aberration, trisomy 8, was demonstrated in AML blasts, glycophorin A-positive erythroblasts, and CD3- and CD20/22-positive small lymphocytes. This suggests that in this patient even lymphocytes belonged to the leukemic clone.
El-Rifai
W
W
Department of Medical Genetics, University of Helsinki, Finland.
Larramendy
M L
ML
Ruutu
T
T
Knuutila
S
S
D000208:Acute Disease; D000368:Aged; D002454:Cell Differentiation; D002898:Chromosomes, Human, Pair 8; D005260:Female; D005838:Genotype; D006801:Humans; D016130:Immunophenotyping; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D010641:Phenotype; D014314:Trisomy; D014407:Tumor Cells, Cultured