title: Immunoglobulin M immunoblot for diagnosis of Borrelia burgdorferi infection in patients with acute facial palsy.
abstract: We used immunoblotting to improve the specificity of the serologic diagnosis of Lyme borreliosis in cases of acute facial palsy. Twelve of 15 patients (80%) with suspected Lyme borreliosis, versus 0 of 10 controls, were positive by immunoglobulin M immunoblotting of acute-phase sera and 3 were negative, including 2 with borderline enzyme immunoassay results. Immunoglobulin M immunoblotting is a useful test to confirm Borrelia burgdorferi infection in patients with acute facial palsy and a positive enzyme immunoassay result.
authors.affiliation: Division of Infectious Diseases, Schneider Children's Hospital, New Hyde Park, New York 11040, USA.
authors.forename: V K
authors.initials: VK
authors.lastname: Jain
authors.forename: E
authors.initials: E
authors.lastname: Hilton
authors.forename: J
authors.initials: J
authors.lastname: Maytal
authors.forename: G
authors.initials: G
authors.lastname: Dorante
authors.forename: N T
authors.initials: NT
authors.lastname: Ilowite
authors.forename: S K
authors.initials: SK
authors.lastname: Sood
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D003289:Convalescence; D005158:Facial Paralysis / Q000097:blood / Q000150:complications / Q000382:microbiology*; D005260:Female; D006801:Humans; D015151:Immunoblotting / Q000379:methods*; D007124:Immunoenzyme Techniques; D007075:Immunoglobulin M / Q000032:analysis*; D008193:Lyme Disease / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged
chemical_list: D000907:Antibodies, Bacterial; D007075:Immunoglobulin M