Developmental toxicity of JP-8 jet fuel in the rat.
JP-8 aviation fuel is being phased in as a replacement for both JP-4 and JP-5 jet fuels presently in use by the Air Force and Navy, respectively. At the present time, 11% of active-duty Air Force personnel are women of child-bearing age. This study was undertaken to determine the threat posed to the unborn fetus should female active-duty personnel come in contact with JP-8 while pregnant. Time-mated Sprague-Dawley rats were dosed orally with JP-8 at 0, 500, 1000, 1500 and 2000 mg kg-1 day-1 on days 6-15 of pregnancy. The number and type of fetal malformations and variations observed did not differ significantly between dose groups. Dams in the 1000, 1500 and 2000 mg kg-1 day-1 groups gained significantly less body weight during pregnancy than did control dams. Embryo toxicity was indicated by a significant reduction in fetal body weight in the 1500 and 2000 mg kg-1 day-1 dose groups.
Cooper
J R
JR
Comparative Medicine Branch/Armstrong Laboratory, Wright-Patterson Air Force Base, OH 45433-7902, USA.
Mattie
D R
DR
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D006838:Hydrocarbons / Q000633:toxicity*; D007648:Kerosene; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D013723:Teratogens / Q000633:toxicity*
D006838:Hydrocarbons; C098607:JP8 aviation fuel; D007648:Kerosene; D013723:Teratogens