title: Procyanidins from tormentil: antioxidant properties towards lipoperoxidation and anti-elastase activity.
abstract: Procyanidins extracted from the rhizomes of Potentilla tormentilla were fractionated according to their degree of polymerization by chromatography on Sephadex LH20. Dimers and trimers displayed the highest anti-radical activity towards lipoperoxidation. Pentamers and hexamers possessed the most marked anti-elastase properties.
authors.affiliation: Laboratoire de Pharmacie Galénique et Pharmacotechnie Industrielle, UFR Pharmacie, Clermont-Ferrand, France.
authors.forename: M A
authors.initials: MA
authors.lastname: Bos
authors.forename: B
authors.initials: B
authors.lastname: Vennat
authors.forename: M T
authors.initials: MT
authors.lastname: Meunier
authors.forename: M P
authors.initials: MP
authors.lastname: Pouget
authors.forename: A
authors.initials: A
authors.lastname: Pourrat
authors.forename: J
authors.initials: J
authors.lastname: Fialip
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification* / Q000494:pharmacology*; D044946:Biflavonoids; D002392:Catechin / Q000302:isolation & purification* / Q000494:pharmacology*; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008969:Molecular Sequence Data; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry*; D044945:Proanthocyanidins; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D044946:Biflavonoids; D010936:Plant Extracts; D044945:Proanthocyanidins; C017674:procyanidin; D002392:Catechin; D010196:Pancreatic Elastase