Effects of OP-1206 (prostaglandin E1) on nerve-conduction velocity in the dog cauda equina subjected to acute experimental compression.
The effect of OP-1206, a prostaglandin E1 derivative, on cauda equina function was analyzed in a model for acute cauda equina compression in the dog. An inflatable balloon was placed under the lamina of the seventh lumbar vertebra in the dog and muscle action potential area (MAP area) and nerve-conduction velocity (NCV) were monitored during 2 h of compression and 1.5 h of recovery. OP-1206 was infused systemically at three concentrations. Only the highest concentration (30 ng/kg/min) of OP-1206 could prevent the reduction in NCV. However, this concentration had no similar effect on the MAP area. The data suggest the potential therapeutic use of prostaglandin E1 analogues for the future treatment of intermittent claudication.
Konno
S
S
Department of Orthopaedic Surgery, Fukushima Medical College, Japan.
Kayama
S
S
Olmarker
K
K
Kikuchi
S
S
D000200:Action Potentials / Q000187:drug effects; D000527:Alprostadil / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D002420:Cauda Equina / Q000187:drug effects* / Q000503:physiopathology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D018482:Muscle, Skeletal / Q000187:drug effects / Q000503:physiopathology; D009408:Nerve Compression Syndromes / Q000503:physiopathology*; D009431:Neural Conduction / Q000187:drug effects*; D009994:Osmolar Concentration; D013997:Time Factors; D014665:Vasodilator Agents / Q000494:pharmacology*
D014665:Vasodilator Agents; C025090:ONO 1206; D000527:Alprostadil