title: Studies on the scale-up of crossflow filtration devices.
abstract: This paper describes a new method that makes it possible to predict the performance of crossflow ultrafiltration and microfiltration when scaling up from small laboratory scale to process-scale systems. Using this method, one characterizes a solution's filtration properties with a specific ultrafiltration or microfiltration membrane in a laboratory-scale crossflow device. Based on experimental results at this scale, one can accurately predict scale-up performance from laboratory through clinical production to full marketing production. Given the need for biopharmaceutical engineers to rapidly predict the size and cost of full-scale filtration processes once products receive regulatory approval, this method will find wide use in the pharmaceutical industry.
authors.affiliation: Chemica Technologies, Incorporated, Bend, Oregon 97701-5711, USA.
authors.forename: D
authors.initials: D
authors.lastname: Brose
authors.forename: M
authors.initials: M
authors.lastname: Dosmar
authors.forename: S
authors.initials: S
authors.lastname: Cates
authors.forename: F
authors.initials: F
authors.lastname: Hutchison
mesh_terms: D004345:Drug Industry; D011237:Predictive Value of Tests; D012996:Solutions; D014462:Ultrafiltration / Q000295:instrumentation / Q000379:methods*
chemical_list: D012996:Solutions