title: Role of ribosome degradation in the death of heat-stressed Salmonella typhimurium.
abstract: Heat treatment of Salmonella typhimurium results in cell death, which coincides with a significant reduction of the cellular content of 16S ribosomal RNA. It is suggested that the degradation of ribosomal RNA is a direct cause of cell death. This conclusion is based on the observation of carbon-starved and magnesium-supplemented cells, which survive heat treatment much better, and which also maintain stable levels of ribosomal RNA.
authors.affiliation: Department of Microbiology, University of Denmark, Lyngby, Copenhagen, Denmark.
authors.forename: T
authors.initials: T
authors.lastname: Tolker-Nielsen
authors.forename: S
authors.initials: S
authors.lastname: Molin
mesh_terms: D002244:Carbon / Q000378:metabolism; D016923:Cell Death; D015342:DNA Probes / Q000235:genetics; D006358:Hot Temperature / Q000009:adverse effects*; D017403:In Situ Hybridization; D008274:Magnesium / Q000378:metabolism; D012336:RNA, Ribosomal, 16S / Q000235:genetics / Q000378:metabolism*; D012338:RNA, Ribosomal, 23S / Q000235:genetics / Q000378:metabolism*; D012486:Salmonella typhimurium / Q000378:metabolism*
chemical_list: D015342:DNA Probes; D012336:RNA, Ribosomal, 16S; D012338:RNA, Ribosomal, 23S; D002244:Carbon; D008274:Magnesium