Inhibitory MHC class I receptors on NK cells and T cells.
Natural killer (NK) and T cells express receptors for polymorphic major histocompatibility complex (MHC) class I molecules, and activation of these receptors results in inhibition of their effector cell function. Genes encoding the murine and human NK-cell receptors have been cloned, and studies of their structure, function and expression are progressing rapidly, as reviewed here by Lewis Lanier and Joseph Phillips.
Lanier
L L
LL
DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA. lanier@dnax.org
Phillips
J H
JH
D000818:Animals; D005786:Gene Expression Regulation; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D015395:Histocompatibility Antigens Class I; D011971:Receptors, Immunologic