title: Postoperative nausea and vomiting. Propofol or thiopentone: does choice of induction agent affect outcome?
abstract: Postoperative nausea and vomiting (PONV) has many causes, including anaesthetic drugs. Choice of induction agent may affect the incidence of PONV, though the evidence is conflicting. We have analysed our database of outcome after surgery. Data on 4173 patients were analysed using multivariate logistic regression, with an overall incidence of PONV 21.3%. Propofol, when compared to thiopentone for induction of anaesthesia, resulted in an 18% reduction in PONV (OR = 0.82, P = 0.03). The likely postoperative benefits of propofol may outweigh concerns about its additional cost.
authors.affiliation: Department of Anaesthesia and Pain Management, Alfred Hospital, Melbourne, Victoria.
authors.forename: P S
authors.initials: PS
authors.lastname: Myles
authors.forename: M
authors.initials: M
authors.lastname: Hendrata
authors.forename: A M
authors.initials: AM
authors.lastname: Bennett
authors.forename: M
authors.initials: M
authors.lastname: Langley
authors.forename: M R
authors.initials: MR
authors.lastname: Buckland
mesh_terms: D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced* / Q000453:epidemiology; D011183:Postoperative Complications / Q000139:chemically induced* / Q000453:epidemiology; D015742:Propofol / Q000009:adverse effects*; D013874:Thiopental / Q000009:adverse effects*; D014839:Vomiting / Q000139:chemically induced* / Q000453:epidemiology
chemical_list: D018686:Anesthetics, Intravenous; D013874:Thiopental; D015742:Propofol