title: Fluorescence studies of DNA and RNA structure and dynamics.
abstract: Fluorescence spectroscopy is increasingly being used as a technique for probing the structure and dynamics of nucleic acids. Recently, fluorescence methods have been used to elucidate the three-dimensional arrangement of complex DNA and RNA structures, characterize structural perturbations resulting from base bulges in helices and junctions, determine helical handedness in solution, and analyze the protein-induced melting of DNA.
authors.affiliation: Scripps Research Institute, Department of Molecular Biology, La Jolla, CA 92037, USA.
authors.forename: D P
authors.initials: DP
authors.lastname: Millar
mesh_terms: D004247:DNA / Q000737:chemistry*; D015342:DNA Probes; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods*
chemical_list: D015342:DNA Probes; D012313:RNA; D004247:DNA