Suspected extragonadal germ-cell cancer syndrome presenting with an orbital mass and elevation of serum CEA, CA 19-9 and CA50 levels.
Patients with extragonadal germ-cell cancer syndrome (EGCCS) represent a subgroup of patients with poorly differentiated carcinoma or adenocarcinoma of an unknown primary site for whom potentially curative therapy is available. We report the case of a young man presenting an orbital tumor and high serum levels of CEA, CA 19-9 and CA50 for whom an initial diagnosis of metastatic poorly differentiated carcinoma was made. Suspecting EGCCS, he was treated as for a germ-cell tumor. While in treatment, he underwent residual orbital mass resection, and the histologic diagnosis was embryonal carcinoma based on alpha-fetoprotein immunoperoxidase staining. We discuss the rare location at diagnosis, the impressive increase in the commonly considered gastrointestinal markers that he showed, and the potential utility of these markers for such patients.
Cruz
J J
JJ
Department of Oncology, University Hospital, Salamanca, Spain.
Dueñas
A
A
Sanchez
C
C
Fonseca
E
E
Gomez
A
A
Martin
G
G
Sanchez
P
P
Navalon
M
M
Garcia-Palomo
A
A
D000328:Adult; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D018395:CA-19-9 Antigen / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood*; D003937:Diagnosis, Differential; D018237:Germinoma / Q000175:diagnosis* / Q000276:immunology / Q000556:secondary*; D006801:Humans; D008297:Male; D009382:Neoplasms, Unknown Primary / Q000175:diagnosis* / Q000276:immunology; D009918:Orbital Neoplasms / Q000209:etiology* / Q000276:immunology* / Q000556:secondary
D015295:Antigens, Tumor-Associated, Carbohydrate; D018395:CA-19-9 Antigen; C082699:CA-50 antigen; D002272:Carcinoembryonic Antigen