Myc-mediated apoptosis.
Mammalian cells contain an intron-less myc gene, such as the rat s-myc gene and human myc L2 gene, which are expressed in rat embryo chondrocytes and human testis, respectively. Our recent findings demonstrated that s-Myc expression suppresses the growth activity and tumorigenicity of glioma cells, indicating that s-Myc acts as a negative regulator in tumor growth. In addition, we found that s-Myc overexpression can effectively induce apoptotic cell death in human and rat glioma cells without serum deprivation, which is distinct from c-Myc-mediated apoptosis.
Kuchino
Y
Y
Biophysics Division, National Cancer Research Institute, Tokyo, Japan.
Asai
A
A
Kitanaka
C
C
D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis; D001483:Base Sequence; D019254:Genes, bcl-2; D016259:Genes, myc; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics; D051381:Rats
D016271:Proto-Oncogene Proteins c-myc