title: Adenocarcinoma in situ of the uterine cervix progressing to invasive adenocarcinoma.
abstract: This report documents a case of adenocarcinoma in situ (AIS) of the cervix progressing to invasive adenocarcinoma. The patient, who was 32-years-old at the time of diagnosis of AIS, was followed with negative smears for 7 years after conization when a smear showed malignant glandular cells. A repeat conization demonstrated well differentiated papillary adenocarcinoma. The patient remains well 8 years after radical hysterectomy and lymph node dissection. The clinicopathological features of this case and a brief review of the literature are presented.
authors.affiliation: Department of Pathology, Box Hill Hospital, Victoria.
authors.forename: G R
authors.initials: GR
authors.lastname: Hocking
authors.forename: J A
authors.initials: JA
authors.lastname: Hayman
authors.forename: A G
authors.initials: AG
authors.lastname: Ostör
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000231:Adenocarcinoma, Papillary / Q000473:pathology*; D000328:Adult; D002278:Carcinoma in Situ / Q000473:pathology*; D019092:Conization; D018450:Disease Progression; D005260:Female; D006801:Humans; D014594:Uterine Neoplasms / Q000473:pathology*; D014626:Vaginal Smears