title: Radiotherapy for extreme hypertrophic pulmonary osteoarthropathy associated with malignancy.
abstract: A patient with florid hypertrophic pulmonary osteoarthropathy (HPOA) associated with metastatic nasopharyngeal carcinoma is presented. Despite the presence of metastatic disease in the thorax and in bone, the patient's main symptom was severe pain from the HPOA, which was temporarily relieved by chemotherapy. Her disease subsequently progressed during chemotherapy and the pain became resistant to conventional treatment, including high dose morphine, non-steriodal anti-inflammatory agents and steriods. It was only with local radiation to the involved joints that the pain could be controlled. Our patient demonstrates that local radiotherapy is an option for the palliation of extreme HPOA.
authors.affiliation: Prince of Wales Hospital, Shatin, Hong Kong.
authors.forename: W
authors.initials: W
authors.lastname: Yeo
authors.forename: S F
authors.initials: SF
authors.lastname: Leung
authors.forename: A T
authors.initials: AT
authors.lastname: Chan
authors.forename: K W
authors.initials: KW
authors.lastname: Chiu
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use; D018771:Arthralgia / Q000188:drug therapy / Q000532:radiotherapy*; D001859:Bone Neoplasms / Q000556:secondary; D002277:Carcinoma / Q000150:complications* / Q000473:pathology / Q000556:secondary; D018450:Disease Progression; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary*; D009020:Morphine / Q000008:administration & dosage / Q000627:therapeutic use; D009303:Nasopharyngeal Neoplasms / Q000150:complications* / Q000473:pathology; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000188:drug therapy / Q000532:radiotherapy*; D010166:Palliative Care; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000701:Analgesics, Opioid; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D009020:Morphine; D011239:Prednisolone