Sonic hedgehog: making the gradient.
The amino-terminal peptide of Sonic hedgehog is a cell-tethered molecule, which nevertheless seems to provide a developmental signal that acts at a distance and has different effects depending on its concentration. Recent structural data suggest that zinc-dependent proteolysis may somehow be involved in Sonic hedgehog's function.
Bumcrot
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Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.
McMahon
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AP
D053823:Hedgehog Proteins; D006868:Hydrolysis; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction; D015534:Trans-Activators; D015032:Zinc / Q000378:metabolism
D053823:Hedgehog Proteins; D011506:Proteins; D015534:Trans-Activators; D015032:Zinc