Failure to unwind causes cancer. Genome stability.
The recent cloning of the gene defective in individuals with Bloom's syndrome has revealed a link between DNA helicases, genetic instability and a predisposition to cancer.
Watt
P M
PM
Imperial Cancer Research Fund Laboratories, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Hickson
I D
ID
D000251:Adenosine Triphosphatases / Q000737:chemistry / Q000378:metabolism*; D001816:Bloom Syndrome / Q000201:enzymology* / Q000235:genetics; D004265:DNA Helicases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D020022:Genetic Predisposition to Disease; D016678:Genome; D006801:Humans; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics; D053484:RecQ Helicases; D029701:Saccharomyces cerevisiae Proteins
D029701:Saccharomyces cerevisiae Proteins; D000251:Adenosine Triphosphatases; C097151:Bloom syndrome protein; C506725:RECQL protein, human; C090472:SGS1 protein, S cerevisiae; D004265:DNA Helicases; D053484:RecQ Helicases