Lactarane type sesquiterpenoids as inhibitors of leukotriene biosynthesis and other, new metabolites from submerged cultures of Lentinellus cochleatus (Pers. ex Fr.) Karst.
Three known sesquiterpenoids of the lactarane and secolactarane type, deoxylactarorufin A (1), blennin A (2) and blennin C (3), have been obtained from cultures of Lentinellus cochleatus (Basidiomycetes) together with the new metabolites (Z)-2-chloro-3-(4-methoxyphenyl)-2-propen-1-ol (4) and lentinellone (5), a protoilludane derivative. The structures were determined by spectroscopic investigations. 1, 2 and 3 are potent inhibitors of leukotriene biosynthesis in rat basophilic leukemia (RBL-1) cells and human peripheral blood leukocytes (PBL).
Wunder
A
A
LB Biotechnologie der Universität, Kaiserslautern, Bundesrepublik Deutschland.
Anke
T
T
Klostermeyer
D
D
Steglich
W
W
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001487:Basidiomycota / Q000254:growth & development / Q000378:metabolism; D002460:Cell Line; D002855:Chromatography, Thin Layer / Q000379:methods; D003470:Culture Media; D015232:Dinoprostone / Q000096:biosynthesis / Q000097:blood; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D006801:Humans; D015471:Leukemia, Basophilic, Acute; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism*; D020024:Leukotriene Antagonists; D007975:Leukotriene B4 / Q000096:biosynthesis / Q000097:blood; D017997:Leukotriene C4 / Q000096:biosynthesis / Q000097:blood; D015289:Leukotrienes / Q000096:biosynthesis*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D051381:Rats; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003470:Culture Media; D020024:Leukotriene Antagonists; D015289:Leukotrienes; D012717:Sesquiterpenes; D007975:Leukotriene B4; D017997:Leukotriene C4; D015232:Dinoprostone