Role of cell-surface molecules of Blastomyces dermatitidis in host-pathogen interactions.
The fungal pathogen Blastomyces dermatitidis produces an adhesin (WI-1) in yeast stages, which contains repetitive regions that bind host-cell receptors. Adhesin and glucan may modulate fungal interactions with macrophages; their level of expression is altered in hypovirulent mutants. Adhesin is also involved in immune responses, and may be important in eliciting the clearance of the fungus.
Klein
B S
BS
Depts of Pediatrics, University of Wisconsin Medical School, Madison, 53792, USA. brklein@macc.wisc.edu
Newman
S L
SL
D018829:Adhesins, Bacterial; D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology; D001758:Blastomyces / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D001759:Blastomycosis / Q000209:etiology*; D002462:Cell Membrane / Q000502:physiology; D005656:Fungal Proteins / Q000235:genetics / Q000276:immunology / Q000502:physiology; D006023:Glycoproteins / Q000235:genetics / Q000276:immunology / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D008969:Molecular Sequence Data; D014774:Virulence / Q000502:physiology
D018829:Adhesins, Bacterial; D001426:Bacterial Proteins; D005656:Fungal Proteins; D006023:Glycoproteins; C053476:invasin, Yersinia