title: Drosophila development: homeodomains and translational control.
abstract: Translation of the transcription factor caudal is repressed at the anterior end of the Drosophila embryo. Surprisingly, the DNA-binding homeodomain of the transcription factor Bicoid mediates this repression by binding caudal mRNA.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA.
authors.forename: P D
authors.initials: PD
authors.lastname: Zamore
authors.forename: R
authors.initials: R
authors.lastname: Lehmann
mesh_terms: D000818:Animals; D001665:Binding Sites; D004330:Drosophila / Q000196:embryology* / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins; D018398:Homeodomain Proteins / Q000235:genetics* / Q000378:metabolism*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism*; D015534:Trans-Activators / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C056478:bcd protein, Drosophila; C084564:cad protein, Drosophila