Localization of human elav-like neuronal protein 1 (Hel-N1) on chromosome 9p21 by chromosome microdissection polymerase chain reaction and fluorescence in situ hybridization.
Hel-N1 is a member of the highly conserved elav family of neuronal genes. It shares considerable sequence homology with HuD, another human member, and both genes are expressed in brain. HuD was recently mapped to chromosome 1p34. Here, we have utilized chromosome microdissection polymerase chain reaction and fluorescence in situ hybridization to map Hel-N1 to chromosome 9p21. The different chromosomal locations of these homologous genes underscore their distinct identities.
Han
J
J
Laboratory of Medical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA.
Knops
J F
JF
Longshore
J W
JW
King
P H
PH
D002874:Chromosome Mapping / Q000379:methods*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D051959:ELAV Proteins; D000067777:ELAV-Like Protein 2; D005821:Genetic Techniques; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D009419:Nerve Tissue Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D016601:RNA-Binding Proteins / Q000235:genetics*
D051959:ELAV Proteins; D000067777:ELAV-Like Protein 2; C086811:ELAVL2 protein, human; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins