Modeling AIDS in a mouse.
Mice that are lacking their own lymphocytes are given a human immune system, which then is infected with HIV. Such models are proving themselves in studies of immunization techniques. They also yield insights into HIV, including its capacity for infecting particular cell types and its so-called accessory genes. The models may even help in establishing precisely how HIV kills host CD4 T cells.
Mosier
D E
DE
Department of Immunology, Scripps Research Institute, La Jolla, Calif, USA.
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000628:therapy; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D004195:Disease Models, Animal; D015754:Genes, nef / Q000235:genetics; D014644:Genetic Variation; D015497:HIV-1 / Q000472:pathogenicity / Q000502:physiology; D006801:Humans; D007167:Immunotherapy; D051379:Mice; D016513:Mice, SCID; D014779:Virus Replication