Prolongation of murine cardiac allograft survival by microspheres containing TNF alpha and IL1-beta neutralizing antibodies.
Efficient delivery of therapeutic agents to a critical microenvironment may increase the efficacy of drugs used to modulate the allograft rejection response. This study demonstrates the ability of the combination of microspheres containing neutralizing anti-TNF alpha and anti-IL1-beta antibodies to significantly prolong murine cardiac allograft survival. These results suggest that the microsphere technique is an efficacious method to target antibody delivery to prolong allograft survival.
Gerber
D A
DA
Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA.
Oettinger
C W
CW
D'Souza
M
M
Milton
G V
GV
Larsen
C P
CP
Pearson
T C
TC
D000818:Animals; D000906:Antibodies / Q000008:administration & dosage* / Q000276:immunology; D006085:Graft Survival / Q000187:drug effects*; D016027:Heart Transplantation / Q000502:physiology*; D007375:Interleukin-1 / Q000276:immunology*; D007457:Iodine Radioisotopes; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008863:Microspheres; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
D000906:Antibodies; D007375:Interleukin-1; D007457:Iodine Radioisotopes; D014409:Tumor Necrosis Factor-alpha