Genetic maps of polymorphic DNA loci on rat chromosome 1.
Genetic linkage maps of loci defined by polymorphic DNA markers on rat chromosome 1 were constructed by genotyping F2 progeny of F344/N x LEW/N, BN/SsN x LEW/N, and DA/Bkl x F344/Hsd inbred rat strains. In total, 43 markers were mapped, of which 3 were restriction fragment length polymorphisms and the others were simple sequence length polymorphisms. Nineteen of these markers were associated with genes. Six markers for five genes, gamma-aminobutyric acid receptor beta3 (Gabrb3), syntaxin 2 (Stx2), adrenergic receptor beta1 (Adrb1), carcinoembryonic antigen gene family member 1 (Cgm1), and lipogenic protein S14 (Lpgp), and 20 anonymous loci were not previously reported. Thirteen gene loci (Myl2, Aldoa, Tnt, Igf2, Prkcg, Cgm4, Calm3, Cgm3, Psbp1, Sa, Hbb, Ins1, and Tcp1) were previously mapped. Comparative mapping analysis indicated that a large portion of rat chromosome 1 is homologous to mouse chromosome 7, although the homologs of two rat genes are located on mouse chromosomes 17 and 19. Homologs of the rat chromosome 1 genes that we mapped are located on human chromosomes 6, 10, 11, 12, 15, 16, and 19.
Ding
Y P
YP
Arthritis and Rheumatism Branch, National Institutes of Health, Bethesda, Maryland, 20892, USA.
Remmers
E F
EF
Du
Y
Y
Longman
R E
RE
Goldmuntz
E A
EA
Zha
H
H
Kotake
S
S
Cannon
G W
GW
Griffiths
M M
MM
Wilder
R L
RL
D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes; D004247:DNA; D005260:Female; D005819:Genetic Markers; D008297:Male; D018895:Microsatellite Repeats; D011110:Polymorphism, Genetic; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew
D005819:Genetic Markers; D004247:DNA