The absence of genetic markers for streptomycin and rifampicin resistance in Mycobacterium avium complex strains.
Mycobacterium avium, Mycobacterium intracellulare complex (MAC) bacilli are an important cause of bacteraemia in AIDS patients but treatment is complicated by their resistance to the usual antimycobacterial agents. In this study of 20 strains of MAC none was found to have the mutations associated with resistance to rifampicin and streptomycin in M. tuberculosis suggesting that MAC have unique mechanisms for resistance to these agents.
Portillo-Gomez
L
L
Laboratory of Mycobacteria, Food and Drug Administration, Bethesda, Maryland 20892, USA.
Nair
J
J
Rouse
D A
DA
Morris
S L
SL
D000595:Amino Acid Sequence; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000904:Antibiotics, Antitubercular / Q000494:pharmacology*; D001483:Base Sequence; D002417:Cattle; D002645:Chickens; D012321:DNA-Directed RNA Polymerases; D004352:Drug Resistance, Microbial; D005819:Genetic Markers; D008969:Molecular Sequence Data; D009154:Mutation; D015269:Mycobacterium avium Complex / Q000187:drug effects* / Q000235:genetics*; D010940:Plant Proteins / Q000235:genetics; D012269:Ribosomal Proteins / Q000235:genetics; D012293:Rifampin / Q000494:pharmacology*; D017386:Sequence Homology, Amino Acid; D013307:Streptomycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular; D005819:Genetic Markers; D010940:Plant Proteins; D012269:Ribosomal Proteins; C101305:RpoB protein, Oryza sativa; C034212:ribosomal protein S12; D012321:DNA-Directed RNA Polymerases; D012293:Rifampin; D013307:Streptomycin