Effect of PG-SPI and PG-KII, two novel and natural tachykinins, on salivary secretion in the rat.
In an in vivo study of salivation in rats, the scialogogic effects of two natural and amphibian tachykinins, PG-SPI and PG-KII, which activate distinct tachykinin receptors, were compared with those of the tachykinins substance P, neurokinin A and B, and kassinin. The rank order of potencies of these peptides injected intravenously on salivation was: PG-SPI = SP > or = PG-KII = KASS > NKA > > NKB. Atropine (1 mg/kg. i.v.) had no effect on PG-SPI-, SP-, and NKA-induced salivation, but reduced that stimulated by PG-KII and KASS. We conclude that PG-SPI and PG-KII increase salivary secretion through different mechanisms and that rat salivary glands contain PG-SPI-and PG-KII-sensitive receptors.
Broccardo
M
M
Institute of Pharmacology, University La Sapienza, Rome, Italy.
Improta
G
G
Brandoni
A
A
Tabacco
A
A
D000595:Amino Acid Sequence; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D017208:Rats, Wistar; D012463:Saliva / Q000187:drug effects / Q000378:metabolism*; D013329:Structure-Activity Relationship; D015320:Tachykinins / Q000494:pharmacology*
D009842:Oligopeptides; C103114:PG-KII peptide; D015320:Tachykinins; C096302:pyroglutamyl-prolyl-asparaginyl-prolyl-aspartyl-glutamyl-phenylalanyl-phenylalanyl-glycyl-leucyl-methioninamide; D001285:Atropine; D011761:Pyrrolidonecarboxylic Acid