title: Laboratory and field studies on the effects of the antibiotic tylosin on honey bee Apis mellifera L. (Hymenoptera: Apidae) development and prevention of American foulbrood disease.
abstract: Laboratory and field studies were conducted to determine the effectiveness of the antibiotic tylosin in preventing and controlling infections of American foulbrood disease (AFB) of honey bees. Studies conducted on immature worker bees maintained in the laboratory revealed that honey bee larvae could tolerate quite a range of doses of antibiotic in their diet. Intermediate doses of tylosin protected very young larvae from becoming infected by Bacillus larvae at a concentration of 1.5 x 10(8) spores/ml of diet. Antibiotic treatment had no measurable effects on larval or pupal developmental rates until the dose reached a lethal level. Bees in field colonies readily consumed tylosin in powered sugar, up to a level of 800 mg/7 g sugar. No negative colony effects were noted at any dosage rates. Protection against infection by American foulbrood was compared to results obtained with 200 mg Terramycin, the standard dose of the only substance currently registered for foulbrood control. Both 200 mg Terramycin and 100 mg tylosin protected the colonies for up to 3 weeks. A 200-mg dose of tylosin protected the colony for an additional week. Doses of 100 mg or more of tylosin were adequate to eliminate signs of AFB infection in overtly diseased colonies.
authors.affiliation: Department of Entomology, University of California, Davis 95616, USA.
authors.forename: C Y
authors.initials: CY
authors.lastname: Peng
authors.forename: E
authors.initials: E
authors.lastname: Mussen
authors.forename: A
authors.initials: A
authors.lastname: Fong
authors.forename: P
authors.initials: P
authors.lastname: Cheng
authors.forename: G
authors.initials: G
authors.lastname: Wong
authors.forename: M A
authors.initials: MA
authors.lastname: Montague
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016863:Bacillaceae Infections / Q000209:etiology / Q000517:prevention & control* / Q000662:veterinary*; D001407:Bacillus / Q000187:drug effects*; D001516:Bees / Q000187:drug effects* / Q000254:growth & development / Q000382:microbiology*; D007814:Larva / Q000187:drug effects; D015645:Tylosin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D015645:Tylosin