title: Influence of low doses of radiation due to 222Rn on proliferation of fibroblasts and MCF-7 human breast cancer cells in vitro.
abstract: The aim of the present study is to analyze the effects of low doses of radiation due to radon (within the range present in the environment) in the proliferation of normal (fibroblasts) and tumoral (MCF-7 human breast cancer cells) mammalian cells. Both fibroblast and MCF-7 cells were incubated in culture media with different levels of radon (doses of 10-15 000 microGy), or non-radon (control). After incubation the number of cells per plate was measured with a hemocytometer. The dissolution of radon in the culture media decreased the proliferation of MCF-7 cells (not the fibroblasts). Within the range of doses used in this experiment, the lowest as well as the highest doses of radiation had the lowest antiproliferative effects. Intermediate doses strongly decreased the number of final cells with respect to those in the control population.
authors.affiliation: Department of Medical Physics, Faculty of Medicine, University of Cantabria, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Soto
authors.forename: L S
authors.initials: LS
authors.lastname: Quindós
authors.forename: S
authors.initials: S
authors.lastname: Cos
authors.forename: E J
authors.initials: EJ
authors.lastname: Sánchez-Barceló
mesh_terms: D016475:3T3 Cells / Q000528:radiation effects*; D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology; D002455:Cell Division / Q000528:radiation effects; D005260:Female; D006801:Humans; D051379:Mice; D011886:Radon / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000528:radiation effects
chemical_list: D011886:Radon