title: Evaluation of atovaquone in the treatment of patients with uncomplicated Plasmodium falciparum malaria.
abstract: The activity of atovaquone in patients with oligosymptomatic Plasmodium falciparum malaria was assessed in an open, non-comparative clinical study. The patients showed a good clinical response, but there was a high rate of recrudescence. The activity of atovaquone in combination with another antimalarial agent should be investigated.
authors.affiliation: Department of Clinical Parasitology, Hospital for Tropical Diseases, London.
authors.forename: P L
authors.initials: PL
authors.lastname: Chiodini
authors.forename: C P
authors.initials: CP
authors.lastname: Conlon
authors.forename: D B
authors.initials: DB
authors.lastname: Hutchinson
authors.forename: J A
authors.initials: JA
authors.lastname: Farquhar
authors.forename: A P
authors.initials: AP
authors.lastname: Hall
authors.forename: T E
authors.initials: TE
authors.lastname: Peto
authors.forename: H
authors.initials: H
authors.lastname: Birley
authors.forename: D A
authors.initials: DA
authors.lastname: Warrell
mesh_terms: D000328:Adult; D000962:Antimalarials / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D053626:Atovaquone; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005069:Evaluation Studies as Topic; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009285:Naphthoquinones / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials; D009285:Naphthoquinones; D053626:Atovaquone