title: Neointimized Gore-Tex graft for ureteral prosthesis in the dog.
abstract: OBJECTIVE
  To determine the feasibility of replacing a ureteral segment with a neointimized Gore-Tex graft.
  
  
  METHODS
  Seven adult mongrel dogs underwent a two-stage operative procedure. The first procedure involved arterializing the graft to stimulate spread of a luminal neoendothelium by transmural capillary growth. Eight weeks after the initial procedure, a segment of the ipsilateral ureter was replaced with a segment of the neointimized graft.
  
  
  RESULTS
  Histologic evaluation of a portion of the graft removed during the second procedure demonstrated transmural neocapillary ingrowth in all grafts; however, there was no neoendothelial growth on the luminal surface. In 5 dogs the graft was occluded with blood clot and was not suitable for a ureteral prosthesis. In 2 dogs the graft was patent and was successfully incorporated into the urinary system. After 1 year of observation, both of these dogs maintained a patent ureter and had no evidence of hydronephrosis on intravenous urogram.
  
  
  CONCLUSIONS
  These data demonstrate that a Gore-Tex graft can be used as a ureteral prosthesis in the dog. The importance of preliminary arterialization, however, remains to be determined.
authors.affiliation: Department of Surgery, University of Mississippi Medical Center, Jackson 39216, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Peters
authors.forename: W B
authors.initials: WB
authors.lastname: Shingleton
authors.forename: D
authors.initials: D
authors.lastname: Morgan
authors.forename: B
authors.initials: B
authors.lastname: Allen
authors.forename: J E
authors.initials: JE
authors.lastname: Fowler
mesh_terms: D000818:Animals; D001187:Artificial Organs; D002196:Capillaries; D004285:Dogs; D011138:Polytetrafluoroethylene; D014513:Ureter / Q000601:surgery*
chemical_list: D011138:Polytetrafluoroethylene