Increased non-angiotensin II [125I]CGP 42112 binding in rat carotid artery after balloon injury.
In this study, [125I]CGP 42112, a ligand of high affinity and selectivity for the angiotensin II AT2 receptor, was used to detect and quantify a non-angiotensin II binding site in the balloon-injured carotid artery of the rat. The amount of [125I]CGP 42112 binding was significantly enhanced in the adventitia of the injured arteries. Localization of the binding site using emulsion autoradiography and immunocytochemistry suggests that the binding sites may be expressed by macrophages in the inflamed tissue surrounding the injured artery.
Viswanathan
M
M
Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1514, USA.
Jöhren
O
O
de Oliveira
M
M
Saavedra
J M
JM
D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D002339:Carotid Arteries / Q000378:metabolism* / Q000473:pathology; D020212:Carotid Artery Injuries; D002404:Catheterization / Q000009:adverse effects*; D007150:Immunohistochemistry; D007249:Inflammation; D007457:Iodine Radioisotopes; D008264:Macrophages; D008297:Male; D009842:Oligopeptides / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011945:Receptors, Angiotensin / Q000378:metabolism
D007457:Iodine Radioisotopes; D009842:Oligopeptides; D011945:Receptors, Angiotensin; D000804:Angiotensin II; C060894:CGP 42112A