title: [Theoretical considerations of dose-rate effect for clinical application: a study of pulsed brachytherapy].
abstract: Pulsed brachytherapy is starting to be used for patients with various kinds of carcinoma, in the expectation of fair treatment results without increasing the late radiation-induced damage. We calculated the early and late biologically effective dose (BED) of this modality to predict early and late radiation damage based on the linear-quadratic model (L-Q model). The way to set the values of alpha/beta and mu (factor of repair) in the L-Q model remains controversial. The value of alpha/beta has been fixed at 3Gy for the late effect and 10Gy for the early effect in recent studies. In this study, we applied these alpha/beta values to calculate the BED, however, the effects of its alteration ranged from 0.5Gy through 15Gy on BED were also analysed. We assumed mu = 0.5 (T1/2 = 1-2 hours) in this study, but we also tried to examine the effects of its variation. Our results indicate that pulsed brachytherapy is a safe treatment procedure even if the dose-rate ranges from 1Gy/hr through 100Gy/hr, but the fractionation number should be increased when using a very high dose rate. Pulsed brachytherapy should be applied cautiously for tissues with a small mu value, such as the spinal cord, because an extremely high late BED would be expected in such cases.
authors.affiliation: Department of Radiology, Keio University School of Medicine.
authors.forename: N
authors.initials: N
authors.lastname: Shigematsu
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: A
authors.initials: A
authors.lastname: Kubo
authors.forename: T
authors.initials: T
authors.lastname: Dokiya
mesh_terms: D001918:Brachytherapy; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy; D012062:Relative Biological Effectiveness