Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein.
To determine the function of the pS2 trefoil protein, which is normally expressed in the gastric mucosa, the mouse pS2 (mpS2) gene was inactivated. The antral and pyloric gastric mucosa of mpS2-null mice was dysfunctional and exhibited severe hyperplasia and dysplasia. All homozygous mutant mice developed antropyloric adenoma, and 30 percent developed multifocal intraepithelial or intramucosal carcinomas. The small intestine was characterized by enlarged villi and an abnormal infiltrate of lymphoid cells. These results indicate that mpS2 is essential for normal differentiation of the antral and pyloric gastric mucosa and may function as a gastric-specific tumor suppressor gene.
Lefebvre
O
O
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/Université Louis Pasteur/Collège de France, Communauté Urbaine de Strasbourg, France.
Chenard
M P
MP
Masson
R
R
Linares
J
J
Dierich
A
A
LeMeur
M
M
Wendling
C
C
Tomasetto
C
C
Chambon
P
P
Rio
M C
MC
D000236:Adenoma / Q000209:etiology / Q000473:pathology; D000818:Animals; D001483:Base Sequence; D002454:Cell Differentiation; D003001:Cloning, Molecular; D005260:Female; D005753:Gastric Mucosa / Q000166:cytology / Q000473:pathology*; D018390:Gene Targeting; D016147:Genes, Tumor Suppressor; D007413:Intestinal Mucosa / Q000166:cytology / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics / Q000502:physiology*; D010641:Phenotype; D011506:Proteins; D011706:Pyloric Antrum; D013274:Stomach Neoplasms / Q000209:etiology* / Q000473:pathology; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins
D009363:Neoplasm Proteins; D011506:Proteins; C051838:TFF1 protein, human; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins