Lymphocyte migration into tissue: the paradigm derived from CD4 subsets.
The appropriate recirculation and migration of naive, effector and memory T cells into inflamed tissue are precisely controlled by adhesive interactions with vascular endothelium. Analyses of CD4 lymphocytes have indicated that naive and antigen-experienced cells exhibit distinctive patterns of homing and recirculation, and that subsets of cells preferentially localize in different anatomical locations as a consequence of previous antigen exposure and differences in adhesion receptor usage.
Bradley
L M
LM
Department of Biology and Cancer Center, University of California, San Diego, La Jolla 92093, USA. lbradley@jeeves.ucsd.edu
Watson
S R
SR
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002465:Cell Movement / Q000276:immunology*; D006801:Humans; D018448:Models, Immunological