title: Coumarins and antiplatelet aggregation constituents from Formosan Peucedanum japonicum.
abstract: Four new khellactone esters, (-)-trans-3'-acetyl-4'-senecioylkhellactone, (+-)-cis-3'-acetyl-4'-tigloylkhellactone, (+-)-cis-4-tigloylkhellactone, (+)-trans-4'-tigloylkhellactone, together with 14 known coumarins, isoimperatorin, psoralen, bergapten, xanthotoxol, cnidilin, (-)-selinidin, (-)-deltoin, (+)-pteryxin, (+)-peucedanocoumarin III, xanthotoxin, imperatorin, (+)-marmesin, (+)-oxypeucedanin hydrate, (+)-peucedanol and three chromones, eugenin, (-)-hamaudol, (+)-visamminol, have been isolated from the root of Formosan Peucedanum japonicum. The structures of the new compounds were elucidated by spectral data. The identities of (+)-trans-3'-tigloyl-4'-acetylkhellactone, formerly reported as a new compound, and (+)-cis-3'-angeloyl-4'-acetyl-khellactone, with the known (+)-peucedanocoumarin III and (+)-pteryxin, respectively, are discussed. Among the isolates, seven compounds, eugenin, (-)-selinidin, (+)-pteryxin, imperatorin, bergapten, cnidilin and (+)-visamminol, show strong antiplatelet aggregation activity in vitro.
authors.affiliation: Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan, ROC.
authors.forename: I S
authors.initials: IS
authors.lastname: Chen
authors.forename: C T
authors.initials: CT
authors.lastname: Chang
authors.forename: W S
authors.initials: WS
authors.lastname: Sheen
authors.forename: C M
authors.initials: CM
authors.lastname: Teng
authors.forename: I L
authors.initials: IL
authors.lastname: Tsai
authors.forename: C Y
authors.initials: CY
authors.lastname: Duh
authors.forename: F N
authors.initials: FN
authors.lastname: Ko
mesh_terms: D003374:Coumarins / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D003374:Coumarins; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors