title: (+)-10 alpha-Hydroxy-4-muurolen-3-one, a new inhibitor of leukotriene biosynthesis from a Favolaschia species. Comparison with other sesquiterpenes.
abstract: A new inhibitor of leukotriene biosynthesis, (+)-10 alpha-hydroxy-4-muurolen-3-one (1), was isolated from fermentations of Favolaschia sp. 87129. Its structure was established by spectroscopic methods. The compound exhibited no antifungal or antibacterial activities. The effects of 1 on leukotriene biosynthesis were compared with (+)-T-cadinol, (-)-3-oxo-T-cadinol, and (+)-3 alpha-hydroxy-T-cadinol, three related sesquiterpenes.
authors.affiliation: LB Biotechnologie der Universität, Kaiserslautern, Bundesrepublik Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Zapf
authors.forename: A
authors.initials: A
authors.lastname: Wunder
authors.forename: T
authors.initials: T
authors.lastname: Anke
authors.forename: D
authors.initials: D
authors.lastname: Klostermeyer
authors.forename: W
authors.initials: W
authors.lastname: Steglich
authors.forename: R
authors.initials: R
authors.lastname: Shan
authors.forename: O
authors.initials: O
authors.lastname: Sterner
authors.forename: W
authors.initials: W
authors.lastname: Scheuer
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D002118:Calcium / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D015232:Dinoprostone / Q000096:biosynthesis / Q000097:blood; D005285:Fermentation; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D066298:In Vitro Techniques; D007939:Leukemia L1210; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism*; D020024:Leukotriene Antagonists; D017997:Leukotriene C4 / Q000096:biosynthesis / Q000097:blood; D015289:Leukotrienes / Q000096:biosynthesis*; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D011124:Polyporaceae; D051381:Rats; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C102553:10-hydroxy-4-muurolen-3-one; D000972:Antineoplastic Agents, Phytogenic; D020024:Leukotriene Antagonists; D015289:Leukotrienes; D012717:Sesquiterpenes; D017997:Leukotriene C4; D015232:Dinoprostone; D002118:Calcium