[Aevit and glutamic acid in the treatment of patients with bronchial asthma].
To elucidate the effect of antioxidants aevit and glutaminic acid on the course of bronchial asthma (BA) and free radical processes in this disease, 54 BA patients were divided into 2 groups: glucocorticoid-untreated and glucocorticoid-treated. Each of two subgroups made of these groups either received antioxidants (AO) or not. The response was assessed by clinical BA symptoms and free radical processes reflecting production of active oxygen forms by leukocytes (PAOFL) and free radical peroxidation (FRPO). PAOFL was studied using luminol-dependent chemiluminescence (CL). CL basal and stimulated values were calculated. FRPO was measured by plasma levels of malonic dialdehyde. Aevit and glutaminic acid treated BA patients improved clinically and exhibited reduced CL of PAOFL and malonic dialdehyde in plasma compared to BA patients on conventional therapy or conventional therapy plus glucocorticoids. Aevit and glutaminic acid are recommended for BA patients.
Daniliak
I G
IG
Kogan
A Kh
AKh
Bolevich
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use*; D001249:Asthma / Q000097:blood / Q000188:drug therapy*; D004338:Drug Combinations; D005260:Female; D005609:Free Radicals; D005938:Glucocorticoids / Q000627:therapeutic use; D018698:Glutamic Acid / Q000627:therapeutic use*; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D014801:Vitamin A / Q000627:therapeutic use*; D014810:Vitamin E / Q000627:therapeutic use*
D000975:Antioxidants; D004338:Drug Combinations; D005609:Free Radicals; D005938:Glucocorticoids; D014801:Vitamin A; D014810:Vitamin E; D018698:Glutamic Acid; D008315:Malondialdehyde; C048974:vitamin A, vitamin E drug combination