Metaphase analysis of metanephric adenoma reveals chromosome Y loss with chromosome 7 and 17 gain.
A 61-year-old man underwent wedge excision of a 3-cm right renal metanephric adenoma. This recently recognized tumor has been considered benign, although no genetic studies have been reported. Metaphase analysis demonstrated a 47,X,-Y,+7,+17 karyotype. These results are consistent with a clonal neoplastic disorder.
Brown
J A
JA
Department of Urology and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Sebo
T J
TJ
Segura
J W
JW
D000236:Adenoma / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008677:Metaphase; D008875:Middle Aged