Quinidine-induced pigmentation.
Antimalarial agents have long been known to cause a variety of pigmentary disturbances. Quinidine, a cincha alkaloid and D-isomer of quinine, is widely used for the treatment of ventricular arrhythmias. A paucity of literature, however, exists concerning quinidine-associated hyperpigmentation. We describe a case of focal ceruloderma we believe to be secondary to quinidine therapy.
Conroy
E A
EA
Department of Dermatology, Cleveland Clinic Foundation, Ohio 44195, USA.
Liranzo
M O
MO
McMahon
J
J
Steck
W D
WD
Tuthill
R J
RJ
D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005533:Foot Dermatoses / Q000139:chemically induced / Q000473:pathology; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced* / Q000473:pathology; D007501:Iron / Q000032:analysis; D007868:Leg Dermatoses / Q000139:chemically induced / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009260:Nail Diseases / Q000139:chemically induced / Q000473:pathology; D011802:Quinidine / Q000008:administration & dosage / Q000009:adverse effects*; D017180:Tachycardia, Ventricular / Q000188:drug therapy; D014034:Toes / Q000473:pathology
D000889:Anti-Arrhythmia Agents; D007501:Iron; D011802:Quinidine