Primary Sjögren's syndrome, ulcerative colitis and selective IgA deficiency.
A 24-year-old man with primary Sjögren's syndrome presented with xerophthalmia, xerostomia, and marked parotid swelling. He had a previous history of selective IgA deficiency and ulcerative colitis treated with sulphasalazine. Immunosuppression and withdrawal of sulphasalazine resulted in rapid resolution of the parotitis and disappearance of autoantibodies. A possible role for sulphasalazine in the induction of autoimmunity in this case is discussed.
Steuer
A
A
Central Middlesex Hospital, London, UK.
McCrea
D J
DJ
Colaco
C B
CB
D000293:Adolescent; D001379:Azathioprine / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000150:complications* / Q000188:drug therapy; D005765:Gastrointestinal Agents / Q000009:adverse effects; D006801:Humans; D017098:IgA Deficiency / Q000139:chemically induced / Q000150:complications*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D012859:Sjogren's Syndrome / Q000150:complications*; D012460:Sulfasalazine / Q000009:adverse effects
D005765:Gastrointestinal Agents; D007166:Immunosuppressive Agents; D012460:Sulfasalazine; D011239:Prednisolone; D001379:Azathioprine