title: Comparison of single-entry and double-entry two-step couple screening for cystic fibrosis carriers.
abstract: Both single-entry two-step (SETS) couple screening and double-entry two-step (DETS) couple screening have been recommended as methods to screen for cystic fibrosis gene carriers. In this paper we compare the expected results from both types of screening. In general, DETS results in a higher detection rate of couples in which both partners are carriers, but also in a higher proportion of couples with only one identified carrier who have a significant remaining risk in their offspring.
authors.affiliation: Department of Human Genetics, Free University, Amsterdam, Netherlands.
authors.forename: L P
authors.initials: LP
authors.lastname: ten Kate
authors.forename: J B
authors.initials: JB
authors.lastname: Verheij
authors.forename: M F
authors.initials: MF
authors.lastname: Wildhagen
authors.forename: H B
authors.initials: HB
authors.lastname: Hilderink
authors.forename: L
authors.initials: L
authors.lastname: Kooij
authors.forename: J G
authors.initials: JG
authors.lastname: Verzijl
authors.forename: J D
authors.initials: JD
authors.lastname: Habbema
mesh_terms: D002648:Child; D003550:Cystic Fibrosis / Q000235:genetics*; D005260:Female; D006580:Genetic Carrier Screening / Q000379:methods*; D006801:Humans; D008297:Male; D008432:Mathematical Computing