title: Biventricular systolic function and mass studied with MR imaging in children with pulmonary regurgitation after repair for tetralogy of Fallot.
abstract: OBJECTIVE
  To study biventricular systolic function and mass of the heart in young patients with residual pulmonary regurgitation who had undergone surgical correction of tetralogy of Fallot.
  
  
  METHODS
  Transverse gradient-echo magnetic resonance (MR) images covering both ventricles were obtained in 19 patients who had undergone corrective surgery for tetralogy of Fallot at the age of 1.5 years +/- 1 and in 12 age-matched control subjects. In addition, MR velocity maps of the pulmonary artery were obtained. Biventricular volumes, ejection fraction and myocardial mass, and pulmonary flow volumes were measured. Exercise tests were performed in 17 patients.
  
  
  RESULTS
  The right ventricular ejection fraction was lower (P < .001) and the right ventricular mass was higher (P < .0005) in patients than in control subjects; the left ventricular ejection fraction was lower (P < .0005) in patients and correlated statistically significantly with pulmonary regurgitation (r = -.68; P < .005). Exercise performance inversely correlated with pulmonary regurgitation (tau = -0.5; P = .01).
  
  
  CONCLUSIONS
  In children who undergo early surgical repair of tetralogy of Fallot, residual pulmonary regurgitation correlates with biventricular systolic dysfunction and diminished exercise capacity. Despite successful surgical correction, right ventricular hypertrophy may persist.
authors.affiliation: Department of Diagnostic Radiology and Nuclear Medicine, Leiden University Hospital, The Netherlands.
authors.forename: R A
authors.initials: RA
authors.lastname: Niezen
authors.forename: W A
authors.initials: WA
authors.lastname: Helbing
authors.forename: E E
authors.initials: EE
authors.lastname: van der Wall
authors.forename: R J
authors.initials: RJ
authors.lastname: van der Geest
authors.forename: S A
authors.initials: SA
authors.lastname: Rebergen
authors.forename: A
authors.initials: A
authors.lastname: de Roos
mesh_terms: D016022:Case-Control Studies; D002648:Child; D015150:Echocardiography, Doppler; D005080:Exercise Test; D005260:Female; D006801:Humans; D017380:Hypertrophy, Right Ventricular / Q000175:diagnosis* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D011183:Postoperative Complications / Q000175:diagnosis* / Q000503:physiopathology; D011651:Pulmonary Artery / Q000503:physiopathology; D011665:Pulmonary Valve Insufficiency / Q000175:diagnosis* / Q000503:physiopathology; D013318:Stroke Volume / Q000502:physiology; D013771:Tetralogy of Fallot / Q000601:surgery*; D016276:Ventricular Function / Q000502:physiology*