title: Dissolution of pseudophakic fibrinous exudate with intraocular streptokinase.
abstract: A fibrinous exudate developed in 8 children after cataract extraction. Blunt trauma was the cause of cataract formation in 6 children; the other 2 presented with congenital cataract. In 4 of 6 children with traumatic cataract, iris damage was evident. Seven children had an intraocular lens implanted. The development of fibrinous exudate in the anterior chamber was noted despite routine post-operative topically administered steroids. It typically formed 1-4 days after surgery. In all cases topical fortified steroids were unsuccessful in hastening dissolution. Intracameral injection of streptokinase (500-1000 IU) caused dissolution of fibrin in all cases. No adverse effects were apparent clinically with intraocular administration of streptokinase.
authors.affiliation: King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
authors.forename: P B
authors.initials: PB
authors.lastname: Mullaney
authors.forename: D T
authors.initials: DT
authors.lastname: Wheeler
authors.forename: T
authors.initials: T
authors.lastname: al-Nahdi
mesh_terms: D000293:Adolescent; D002387:Cataract Extraction; D002648:Child; D002675:Child, Preschool; D005122:Exudates and Transudates / Q000187:drug effects*; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D007267:Injections; D007910:Lenses, Intraocular; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*; D013300:Streptokinase / Q000008:administration & dosage*
chemical_list: D005343:Fibrinolytic Agents; D013300:Streptokinase