title: A cellular automata model of the heart and its coupling with a qualitative model.
abstract: Cellular Automata (CA) models offer a good compromise between computational complexity and biological plausibility while qualitative models have expressive power for explicitly describing dynamic processes. In this paper we present a 2D CA model and its coupling with a qualitative model. The CA model includes elements characterizing muscle, nodal tissue, and bypass conduction. Each element exhibits adaptive properties to cycle length and to the prematurity of incoming impulses. A crude electrocardiogram is also simulated via an equivalent source formulation. Arrhythmias such as the Wenckebach phenomenon, atrial flutter, or extrasystole-triggered tachyarrhythmias can be simulated using relatively simple models when they incorporate the fast conduction system with muscle tissue and when the model elements exhibit adaptive properties. We then illustrate how a CA model can be coupled to a qualitative model to produce a system that combines the fine grained description of CA models with the high level interpretative role of qualitative models.
authors.affiliation: Départment d'Information Médicale, Université de Rennes I, France.
authors.forename: P
authors.initials: P
authors.lastname: Siregar
authors.forename: J P
authors.initials: JP
authors.lastname: Sinteff
authors.forename: M
authors.initials: M
authors.lastname: Chahine
authors.forename: P
authors.initials: P
authors.lastname: Lebeux
mesh_terms: D000222:Adaptation, Physiological; D001281:Atrial Fibrillation / Q000503:physiopathology; D001282:Atrial Flutter / Q000503:physiopathology; D003198:Computer Simulation; D004562:Electrocardiography; D006321:Heart / Q000502:physiology* / Q000503:physiopathology; D006327:Heart Block / Q000503:physiopathology; D006329:Heart Conduction System / Q000502:physiology; D006339:Heart Rate; D006801:Humans; D008564:Membrane Potentials; D008955:Models, Cardiovascular; D009206:Myocardium; D012032:Refractory Period, Electrophysiological; D017180:Tachycardia, Ventricular / Q000503:physiopathology; D014693:Ventricular Fibrillation / Q000503:physiopathology; D018879:Ventricular Premature Complexes / Q000503:physiopathology