Effects of the mycelial extract of cultured Cordyceps sinensis on in vivo hepatic energy metabolism in the mouse.
Mice were given the extract of cultured Cordyceps sinensis (Cs) (200 mg/kg daily, p.o.) for 3 weeks. In vivo phosphorus-31 nuclear magnetic resonance (NMR) spectra of the liver were acquired at weekly intervals using a surface coil. From 1 to 3 weeks, a consistent increase in the ATP/inorganic phosphate ratio, which represents the high energy state, was observed in the Cs extract-treated mice. The intracellular pH of the Cs extract-treated mice was not significantly different from that of the control mice. No steatosis, necrosis, inflammation or fibrosis were observed in the liver specimens from Cs extract-treated mice.
Manabe
N
N
Department of Animal Science, Kyoto University, Japan.
Sugimoto
M
M
Azuma
Y
Y
Taketomo
N
N
Yamashita
A
A
Tsuboi
H
H
Tsunoo
A
A
Kinjo
N
N
Nian-Lai
H
H
Miyamoto
H
H
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004734:Energy Metabolism; D006863:Hydrogen-Ion Concentration; D006999:Hypocreales; D008099:Liver / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010710:Phosphates / Q000378:metabolism; D010758:Phosphorus
D004365:Drugs, Chinese Herbal; D010710:Phosphates; D010758:Phosphorus; D000255:Adenosine Triphosphate