Regulation of IGFBP-1 in humans.
IGFBP-1 secretion in humans is regulated by insulin and the counter-regulatory hormones with a high production rate and rapid turnover. The IGFBP-1 fasting levels are both genetically and environmentally determined. Serum IGFBP-1 levels may be regulated by so far unknown factors during certain conditions. The fasting IGFBP-1 level can be used as a marker of diurnal IGFBP-1 and insulin secretion.
Brismar
K
K
Department of Molecular Medicine, Unit for Endocrinology and Diabetology, Karolinska Institute, Stockholm, Sweden.
Hilding
A
A
Lindgren
B
B
D003920:Diabetes Mellitus / Q000378:metabolism; D005215:Fasting; D005260:Female; D006801:Humans; D007328:Insulin / Q000502:physiology; D007333:Insulin Resistance; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D008196:Lymph / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate
D007328:Insulin; D018970:Insulin-Like Growth Factor Binding Protein 1