title: Fractionated stereotactic radiotherapy for the treatment of acoustic neuromas: preliminary results.
abstract: OBJECTIVE
  To evaluate the efficacy and toxicity of fractionated, stereotactic radiotherapy (SRT) for acoustic neuromas.
  
  
  METHODS
  Twelve patients with acoustic neuroma were treated with SRT between June 1992 and October 1994. Follow-up ranged from 16-44 months. Patient age ranged from 27-70 (median: 45). Eight patients were treated with primary SRT and four patients were treated after primary surgical intervention for recurrent [3] or persistent [1] disease. Tumor volumes were 1.2-18.4 cm3 (median: 10.1 cm3). Collimator sizes ranged from 30-50 mm (median: 37.5). Tumors received 1.8 Gy/day normalized to the 95% isodose line. Patients received a minimum prescribed dose of 54 Gy in 27-30 fractions over a 6-week period.
  
  
  RESULTS
  After a median follow-up of 26.5 months, local control was obtained in 12 out of 12 lesions. Tumor regression was noted in three patients, and tumor stabilization was found in the remaining nine patients. No patient developed a new cranial nerve deficit. One patients developed worsening of preexisting Vth cranial neuropathy and another experienced a decrease in hearing. However, all nine patients with useful hearing prior to SRT maintained useful hearing at last follow-up.
  
  
  CONCLUSIONS
  Stereotactic radiotherapy provided excellent local control without new cranial nerve deficits. These results must be viewed as tentative in nature because of the small number of patients and the short median follow-up period.
authors.affiliation: Department of Radiation Oncology, Harvard Medical School, Boston MA, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Varlotto
authors.forename: D C
authors.initials: DC
authors.lastname: Shrieve
authors.forename: E
authors.initials: E
authors.lastname: Alexander
authors.forename: H M
authors.initials: HM
authors.lastname: Kooy
authors.forename: P M
authors.initials: PM
authors.lastname: Black
authors.forename: J S
authors.initials: JS
authors.lastname: Loeffler
mesh_terms: D000328:Adult; D006801:Humans; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000532:radiotherapy*; D016634:Radiosurgery / Q000379:methods*; D011879:Radiotherapy Dosage; D014057:Tomography, X-Ray Computed