title: [Serum sodium imbalance in the bedridden elderly. Part One: Realities and problem of management].
abstract: Symptoms and other abnormalities associated with serum sodium imbalance were studied in bedridden elderly and healthy elderly subjects. 1. A significantly higher number of the bedridden elderly suffered from chronic wasting disease. 2. The average serum sodium concentration in bedridden elderly subjects was significantly lower than in healthy subjects, as was the sodium intake and the sodium content in urine, which indicate that the bedridden elderly subjects suffered from chronic sodium deficiency. 3. The bedridden elderly subjects had high levels of plasma PRA and antidiuretic hormone, and their aldosterone levels were low, which indicate that their condition was associated with a decrease in available circulating plasma, hypersecretion of antidiuretic hormone, and a decline in the ability to retain sodium. 4. Measurement of 24-hr creatinine clearance, albumin, and beta 2-microglobulin in urine revealed that bedridden elderly subjects had high levels of renal dysfunction, the result of which may a disturbance in water excretion. Abnormalities in serum sodium levels in the bedridden elderly subjects were related to a chronic deficiency in sodium intake, which reduced their ability to maintain sodium levels and impaired their renal function. Iatrogenic factors are likely to play an important role in the genesis of this condition, and should be taken into account in during management.
authors.affiliation: Department of Internal Medicine, Omotemachi Hospital.
authors.forename: A
authors.initials: A
authors.lastname: Sasaki
authors.forename: D
authors.initials: D
authors.lastname: Kogure
authors.forename: K
authors.initials: K
authors.lastname: Ogawa
authors.forename: H
authors.initials: H
authors.lastname: Sakurai
authors.forename: H
authors.initials: H
authors.lastname: Katsunuma
authors.forename: Y
authors.initials: Y
authors.lastname: Maehata
authors.forename: M
authors.initials: M
authors.lastname: Takasaki
mesh_terms: D000368:Aged; D001510:Bed Rest; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007049:Iatrogenic Disease; D007674:Kidney Diseases / Q000150:complications; D008297:Male; D012964:Sodium / Q000172:deficiency*; D014667:Vasopressins / Q000097:blood; D014883:Water-Electrolyte Imbalance / Q000150:complications
chemical_list: D014667:Vasopressins; D012964:Sodium