title: Effects of prolonged low exposure to methyl isocyanate.
abstract: An assessment of human pulmonary effects from long-term, low-level exposure to methyl isocyanate (MIC) has been undertaken. Serial pulmonary function data, cigarette smoking histories, and other information were available for over 400 workers from a large chemical facility. In addition, industrial-hygiene measurements had been made and were used to classify jobs according to level of MIC exposure. In some instances, work records were incomplete and workers' predominant job and extent of inferred exposures were therefore based on the ratings of their supervisors and coworkers. The availability of these data allowed us to evaluate the frequency of pulmonary impairment in workers according to the assumed four levels of MIC exposure. No specific or consistent pulmonary impairment was evident. Long-term, low-level exposure to MIC at the levels existing at this particular facility could not be shown to be producing detectable effects on lung function.
authors.affiliation: Department of Community Medicine, West Virginia University, Morgantown, USA.
authors.forename: B
authors.initials: B
authors.lastname: Avashia
authors.forename: M C
authors.initials: MC
authors.lastname: Battigelli
authors.forename: W K
authors.initials: WK
authors.lastname: Morgan
authors.forename: R B
authors.initials: RB
authors.lastname: Reger
mesh_terms: D000395:Air Pollutants, Occupational / Q000009:adverse effects* / Q000032:analysis; D000402:Airway Obstruction / Q000139:chemically induced / Q000453:epidemiology; D000704:Analysis of Variance; D002617:Chemical Industry; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D017953:Isocyanates / Q000009:adverse effects* / Q000032:analysis; D008137:Longitudinal Studies; D008168:Lung / Q000187:drug effects*; D016273:Occupational Exposure / Q000009:adverse effects* / Q000145:classification / Q000706:statistics & numerical data*; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D013997:Time Factors; D014797:Vital Capacity / Q000187:drug effects
chemical_list: D000395:Air Pollutants, Occupational; D017953:Isocyanates; C008461:methyl isocyanate