The effect of Yohimbine, an alpha2 adrenergic receptor antagonist, on the growth hormone response to apomorphine in normal subjects.
Yohimbine HCl (16 mg po) administered 30 min before clonidine (CLON) (2 ug/kg infused over 10 min) (N = 5) or apomorphine HCl (Apo) (0.5 mg sc) (N = 10) antagonized the growth hormone (GH) response to CLON but had no effect on the GH response to Apo in normal men. This finding suggests that in humans, alpha2 adrenergic mechanisms do not modulate dopaminergic function, at least not in the hypothalamic-pituitary axis, and that the GH response to Apo is not mediated via an alpha2 adrenergic link.
Lal
S
S
Douglas Hospital Research Centre, Verdun, Quebec, Canada.
Thavundayil
J X
JX
Krishnan
B
B
Nair
N P
NP
Schwartz
G
G
Guyda
H
H
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000328:Adult; D001058:Apomorphine / Q000378:metabolism*; D003000:Clonidine / Q000378:metabolism; D018491:Dopamine Agonists / Q000378:metabolism*; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects; D010919:Placebos; D015016:Yohimbine / Q000494:pharmacology*
D000317:Adrenergic alpha-Antagonists; D018491:Dopamine Agonists; D010919:Placebos; D015016:Yohimbine; D013006:Growth Hormone; D003000:Clonidine; D001058:Apomorphine