title: Long term effect of renal transplantation on dialysis-related amyloid deposits and symptomatology.
abstract: We report the five year outcome of nine patients with dialysis-related amyloid (DRA) who underwent successful renal transplantation (RT) and six patients who remained on hemodialysis (HD). Amyloid bone cysts, a radiologic feature of DRA, and scintigraphy with 123I-labeled serum amyloid P component (SAP), a specific technique for evaluating amyloid deposits in vivo, were monitored and compared with clinical features. In all HD patients there was clinical, scintigraphic and/or radiologic evidence that DRA progressed. In contrast, eight of the RT patients experienced profound early relief of DRA symptoms following transplantation that persisted throughout follow-up, despite the reduction or withdrawal of corticosteroids. Amyloid bone cysts improved in four patients and SAP scans demonstrated regression of articular amyloid in eight out of nine cases. The modest radiographic improvement suggests that amyloid is mobilized more slowly in bone cysts than elsewhere or that cystic bone is remodeled poorly. This is the first objective evidence that DRA regresses following renal transplantation, and suggests that this may contribute to the long-term relief of DRA symptoms in transplant recipients who discontinue corticosteroids.
authors.affiliation: Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom.
authors.forename: S Y
authors.initials: SY
authors.lastname: Tan
authors.forename: A
authors.initials: A
authors.lastname: Irish
authors.forename: C G
authors.initials: CG
authors.lastname: Winearls
authors.forename: E A
authors.initials: EA
authors.lastname: Brown
authors.forename: P E
authors.initials: PE
authors.lastname: Gower
authors.forename: E J
authors.initials: EJ
authors.lastname: Clutterbuck
authors.forename: S
authors.initials: S
authors.lastname: Madhoo
authors.forename: J P
authors.initials: JP
authors.lastname: Lavender
authors.forename: M B
authors.initials: MB
authors.lastname: Pepys
authors.forename: P N
authors.initials: PN
authors.lastname: Hawkins
mesh_terms: D000328:Adult; D000368:Aged; D000682:Amyloid / Q000378:metabolism*; D005260:Female; D006801:Humans; D007592:Joint Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011859:Radiography; D006435:Renal Dialysis / Q000009:adverse effects*; D000683:Serum Amyloid P-Component / Q000378:metabolism
chemical_list: D000682:Amyloid; D000683:Serum Amyloid P-Component