Somatostatin analogues and exocrine pancreatic secretion.
Subcutaneous injection of 50 micrograms octreotide before a meal can almost totally prevent the increase in exocrine pancreatic secretions caused by the meal. Octreotide inhibits plasma amino acid uptake by pancreatic acinar cells, and thus synthesis of pancreatic enzymes. This effect has clinical potential.
Gullo
L
L
Department of Medicine and Gastroenterology, University of Bologna, St. Orsola Hospital, Italy.
D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology*; D002478:Cells, Cultured; D006727:Hormone Antagonists / Q000494:pharmacology*; D006801:Humans; D015282:Octreotide / Q000494:pharmacology*; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000494:pharmacology*
D018931:Antineoplastic Agents, Hormonal; D006727:Hormone Antagonists; D013004:Somatostatin; D015282:Octreotide