title: Oral treatment of late Lyme borreliosis with a combination of roxithromycin and co-trimoxazole--a pilot study on 18 patients.
abstract: In this pilot trial, 18 patients participated in an investigation in which the combined therapy of co-trimoxazole and roxithromycin in late Lyme borreliosis was tested. The study has been performed as a result of earlier case reports in "The Lancet" where this combination has been used successfully in order to thwart late Lyme disease. The authors show that 76% of the patients recovered completely. In 2 patients, symptoms could be resolved with i.v. penicillin and 2 did not respond to any antibiotic therapy. These results show that oral therapy of co-trimoxazole and roxithromycin in combination provides similar results as i.v. antibiotics in earlier studies.
authors.affiliation: Department of Internal Medicine, University Graz.
authors.forename: R
authors.initials: R
authors.lastname: Gasser
authors.forename: E
authors.initials: E
authors.lastname: Reisinger
authors.forename: B
authors.initials: B
authors.lastname: Sedaj
authors.forename: R
authors.initials: R
authors.lastname: Horvarth
authors.forename: G
authors.initials: G
authors.lastname: Seinost
authors.forename: A
authors.initials: A
authors.lastname: Keplinger
authors.forename: I
authors.initials: I
authors.lastname: Wendelin
authors.forename: W
authors.initials: W
authors.lastname: Klein
mesh_terms: D000284:Administration, Oral; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008193:Lyme Disease / Q000175:diagnosis / Q000188:drug therapy*; D010865:Pilot Projects; D015575:Roxithromycin / Q000009:adverse effects / Q000627:therapeutic use*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D015575:Roxithromycin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination