title: A genetic analysis of pannier, a gene necessary for viability of dorsal tissues and bristle positioning in Drosophila.
abstract: A genetic and phenotypic analysis of the gene pannier is described. Animals mutant for strong alleles die as embryos in which the cells of the amnioserosa are prematurely lost. This leads to a dorsal cuticular hole. The dorsal-most cells of the imagos are also affected: viable mutants exhibit a cleft along the dorsal midline. pannier mRNA accumulates specifically in the dorsal-most regions of the embryo and the imaginal discs. Viable mutants and mutant combinations also affect the thoracic and head bristle patterns in a complex fashion. Only those bristles within the area of expression of pannier are affected. A large number of alleles have been studied and reveal that pannier may have opposing effects on the expression of achaete and scute leading to a loss or a gain of bristles.
authors.affiliation: Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France. pascal@igbmc.u-strasbg.fr
authors.forename: P
authors.initials: P
authors.lastname: Heitzler
authors.forename: M
authors.initials: M
authors.lastname: Haenlin
authors.forename: P
authors.initials: P
authors.lastname: Ramain
authors.forename: M
authors.initials: M
authors.lastname: Calleja
authors.forename: P
authors.initials: P
authors.lastname: Simpson
mesh_terms: D000483:Alleles; D000818:Animals; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D018628:Gene Dosage; D008297:Male; D009154:Mutation; D012333:RNA, Messenger; D013909:Thorax; D014157:Transcription Factors / Q000235:genetics*; D016335:Zinc Fingers / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D014157:Transcription Factors