title: Structure-activity relationships of novel hematoregulatory peptides.
abstract: Hematopoiesis is a lifelong cell renewal process regulated by a family of lineage specific hematopoietic growth factors. Several hematopoietic growth factors such as G-CSF, GM-CSF, and M-CSF have been clinically evaluated for enhancement of host defense in normal and immunocompromised patients and for the treatment of infectious diseases. This paper reports the structure-activity relationships of low molecular weight hematoregulatory peptides based on a nonapeptide (1, SK&F 107647). Like the macromolecular growth factors, these peptides modulate host defense. A molecular target for this class of compounds has not yet been identified. However, the structure-activity relationships established by this study implicate a very specific molecular recognition event that is pivotal for the biological activities of 1 and its analogues.
authors.affiliation: Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA.
authors.forename: P K
authors.initials: PK
authors.lastname: Bhatnagar
authors.forename: E K
authors.initials: EK
authors.lastname: Agner
authors.forename: D
authors.initials: D
authors.lastname: Alberts
authors.forename: B E
authors.initials: BE
authors.lastname: Arbo
authors.forename: J F
authors.initials: JF
authors.lastname: Callahan
authors.forename: A S
authors.initials: AS
authors.lastname: Cuthbertson
authors.forename: S J
authors.initials: SJ
authors.lastname: Engelsen
authors.forename: H
authors.initials: H
authors.lastname: Fjerdingstad
authors.forename: M
authors.initials: M
authors.lastname: Hartmann
authors.forename: D
authors.initials: D
authors.lastname: Heerding
authors.forename: J
authors.initials: J
authors.lastname: Hiebl
authors.forename: W F
authors.initials: WF
authors.lastname: Huffman
authors.forename: M
authors.initials: M
authors.lastname: Hysben
authors.forename: A G
authors.initials: AG
authors.lastname: King
authors.forename: P
authors.initials: P
authors.lastname: Kremminger
authors.forename: C
authors.initials: C
authors.lastname: Kwon
authors.forename: S
authors.initials: S
authors.lastname: LoCastro
authors.forename: D
authors.initials: D
authors.lastname: Løvhaug
authors.forename: L M
authors.initials: LM
authors.lastname: Pelus
authors.forename: S
authors.initials: S
authors.lastname: Petteway
authors.forename: J S
authors.initials: JS
authors.lastname: Takata
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001854:Bone Marrow Cells; D002460:Cell Line; D003114:Colony-Forming Units Assay; D004305:Dose-Response Relationship, Drug; D006410:Hematopoiesis / Q000187:drug effects*; D016298:Hematopoietic Cell Growth Factors / Q000096:biosynthesis*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D009842:Oligopeptides / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D010848:Picolinic Acids / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology; D017154:Stromal Cells / Q000187:drug effects / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D016298:Hematopoietic Cell Growth Factors; D009842:Oligopeptides; D010848:Picolinic Acids; C101620:picolinoyl-seryl-aspartyl-picolinoyl-seryl-aspartyl-2,5-diaminoadipoyl-lysyl-lysine; C086049:SK&F 107647