Larvicidal constituents of Melantheria albinervia.
Bioactivity-guided fractionation has led to the isolation of two larvicidal diterpenes, active against the yellow fever-transmitting mosquito Aedes aegypti, from a dichloromethane root extract of Melantheria albinervia (Asteraceae), a plant from Zimbabwe. These diterpenes were identified as ent-kaur-16-en-19-oic acid and 9(11),16-kauradien-19-oic acid. The diterpenes were also weakly active against Bacillus subtilis.
Slimestad
R
R
Institut de Pharmacognosie et Phytochimie, Université de Lausanne, Switzerland.
Marston
A
A
Mavi
S
S
Hostettmann
K
K
D000330:Aedes / Q000187:drug effects* / Q000196:embryology / Q000821:virology; D000818:Animals; D004224:Diterpenes / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects*; D009032:Mosquito Control; D010944:Plants / Q000737:chemistry*
C101982:9(11),16-kauradien-19-oic acid; D004224:Diterpenes; C014341:argyrophilic acid