title: Effects of strenuous exercise on serum myosin heavy chain fragments in male triathletes.
abstract: During the Nice Triathlon (June 26, 1994), the serum levels of type I myosin heavy chain (MHC) fragments and creatine kinase (CK and CK-MB) activities were assessed in 12 athletes in order to evaluate the exercise-induced muscle damage. Blood samples (BS) were taken 2 days before the event (baseline), on arrival, 6 and 24 h later, and 2 and 4 days later. The mean results (and SD) were respectively: MHC (microU.I-1): 142 (69), 156 (116), 242 (144), 1183 (574), 2603 (1405), 1002 (523); CK (U.I-1): 109 (27), 626 (267), 1188 (562), 1159 (442), 633 (385), 224 (119). The CK peak occurred at BS-6h for 8 subjects, and at BS-24h for the other ones. The MHC peak occurred at BS-48h in all the subjects. The CK-MB/CK ratios exhibited a profile similar to those described previously. Serum MHC peak values were correlated with CK ones (r = 0.67; p < 0.05). After a four-day recovery period, as the CK values had decreased, the MHC levels were still elevated. The main result of the study is the MHC peak occurrence at BS-48h in all the subjects.
authors.affiliation: Centre National de la Recherche Scientifique (UPR 9041), Université d'Aix-Marseille II.
authors.forename: E
authors.initials: E
authors.lastname: Prou
authors.forename: I
authors.initials: I
authors.lastname: Margaritis
authors.forename: F
authors.initials: F
authors.lastname: Tessier
authors.forename: J F
authors.initials: JF
authors.lastname: Marini
mesh_terms: D000328:Adult; D003402:Creatine Kinase / Q000097:blood; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007527:Isoenzymes; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology*; D018995:Myosin Heavy Chains / Q000097:blood*; D010807:Physical Endurance / Q000502:physiology; D013997:Time Factors
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase; D018995:Myosin Heavy Chains