title: Intrarectal transmission of simian immunodeficiency virus in rhesus macaques: selective amplification and host responses to transient or persistent viremia.
abstract: Intrarectal simian immunodeficiency virus (SIV) infection in rhesus macaques is a model for sexual transmission of primate retroviruses. Phylogenetic studies on envelope gene sequences that were present in blood following intrarectal SIV inoculation provided evidence for selective amplification of a subset of viruses present in the inoculum and defined one amino acid sequence uniquely associated with intrarectal infection. Both persistent and transient viremia states were observed after intrarectal infection. Immune responses in persistently infected animals accounted for slower rates of disease progression despite the presence of highly pathogenic viruses that were documented by transfusion studies. Transient viremia elicited protective immunity against subsequent intrarectal virus challenge but did not protect against intravenous virus challenge. Transient viremia usually but not always led to self-limiting infection. In one animal, we documented a relapse to active viremia long after the initial transient viremia. SIV transmission across mucosal barriers affects pathogenesis in the short term by limiting the types of viruses established in the host and in the longer term by establishing host responses that slow disease progression despite the presence of highly pathogenic viruses in blood.
authors.affiliation: Department of Pathology, University of Wisconsin, Madison 53706, USA.
authors.forename: P
authors.initials: P
authors.lastname: Trivedi
authors.forename: D
authors.initials: D
authors.lastname: Horejsh
authors.forename: S B
authors.initials: SB
authors.lastname: Hinds
authors.forename: I I
authors.initials: II
authors.lastname: Hinds PW
authors.forename: M S
authors.initials: MS
authors.lastname: Wu
authors.forename: M S
authors.initials: MS
authors.lastname: Salvato
authors.forename: C D
authors.initials: CD
authors.lastname: Pauza
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005784:Gene Amplification; D005814:Genes, Viral; D008253:Macaca mulatta; D008969:Molecular Sequence Data; D010802:Phylogeny; D012007:Rectum / Q000821:virology*; D016415:Sequence Alignment; D016097:Simian Acquired Immunodeficiency Syndrome / Q000097:blood / Q000635:transmission* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000235:genetics*; D014759:Viral Envelope Proteins / Q000097:blood / Q000235:genetics*; D014766:Viremia
chemical_list: D014759:Viral Envelope Proteins