A new series of coumarin derivatives having monoamine oxidase inhibitory activity from Monascus anka.
Monankarins A-F (1-6), a new series of pigments having conjugated pyrano-coumarin skeleton have been isolated from Monascus anka. Their structures have been elucidated by spectroscopic means and chemical modification. Monankarins A-D exhibited monoamine oxidase (MAO) inhibitory activity, while the activity was not observed in monankarins E and F or some other simple coumarins. Monankarin C (3) showed stronger inhibition of MAO-B than MAO-A in mice brain. However, the specificity was not found in mice liver MAO.
Hossain
C F
CF
Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Okuyama
E
E
Yamazaki
M
M
D000818:Animals; D001203:Ascomycota / Q000737:chemistry*; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003374:Coumarins / Q000302:isolation & purification* / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008996:Monoamine Oxidase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology*
D003374:Coumarins; D008996:Monoamine Oxidase Inhibitors