title: Reduction of urinary basic fibroblast growth factor using pentosan polysulphate sodium.
abstract: OBJECTIVE
  To evaluate the use of pentosan polysulphate sodium (PPS) to reduce the level of urinary basic fibroblast growth factor (bFGF).
  
  
  METHODS
  Forty-one patients with a clam enterocystoplasty were randomized to receive either 200 mg three times daily of oral PPS (n = 21) or placebo (n = 20) for 6 weeks. Three patients acted as a cross-over study. Urinary bFGF was measured before and after treatment and the degree of symptomatic benefit assessed using a questionnaire.
  
  
  RESULTS
  There was no reduction in bFGF in the patients receiving placebo (P = 0.235) but there was a statistically significant reduction in bFGF (P = 0.0251) in the patients receiving PPS, most of whom were symptomatically improved, especially with regard to mucus production.
  
  
  CONCLUSIONS
  PPS may have a role in reducing urinary bFGF in patients with bladder tumours or following an enterocystoplasty and also in improving the quality of life of patients with a clam enterocystoplasty.
authors.affiliation: Department of Urology, Cardiff Royal Infirmary, UK.
authors.forename: J W
authors.initials: JW
authors.lastname: Barrington
authors.forename: S
authors.initials: S
authors.lastname: Fulford
authors.forename: L
authors.initials: L
authors.lastname: Fraylin
authors.forename: R
authors.initials: R
authors.lastname: Fish
authors.forename: M
authors.initials: M
authors.lastname: Shelley
authors.forename: T P
authors.initials: TP
authors.lastname: Stephenson
mesh_terms: D000293:Adolescent; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use*; D002648:Child; D018592:Cross-Over Studies; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000652:urine*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010426:Pentosan Sulfuric Polyester / Q000627:therapeutic use*; D011182:Postoperative Care; D001749:Urinary Bladder Neoplasms / Q000601:surgery
chemical_list: D000925:Anticoagulants; D016222:Fibroblast Growth Factor 2; D010426:Pentosan Sulfuric Polyester