title: A case of Churg-Strauss syndrome: tissue diagnosis established by sigmoidoscopic rectal biopsy.
abstract: A case is presented of Churg-Strauss syndrome in a young man in whom the definitive diagnostic procedure was a full thickness sigmoidoscopic rectal biopsy, with submucosal sampling. Gastrointestinal changes in Churg-Strauss syndrome, a rare systemic illness characterised by asthma, blood and tissue eosinophilia, vasculitis, and granulomatous inflammation are common but poorly reported. The endoscopic and histopathological features of a case are described and emphasise the potential value of a limited sigmoidoscopy in establishing the diagnosis, when lower gastrointestinal symptoms are present.
authors.affiliation: Department of Histopathology, Guy's Hospital, London.
authors.forename: E J
authors.initials: EJ
authors.lastname: Leen
authors.forename: P J
authors.initials: PJ
authors.lastname: Rees
authors.forename: J D
authors.initials: JD
authors.lastname: Sanderson
authors.forename: M L
authors.initials: ML
authors.lastname: Wilkinson
authors.forename: M I
authors.initials: MI
authors.lastname: Filipe
mesh_terms: D000328:Adult; D001706:Biopsy; D015267:Churg-Strauss Syndrome / Q000473:pathology*; D006801:Humans; D008297:Male; D012002:Rectal Diseases / Q000473:pathology*; D012810:Sigmoid Diseases / Q000473:pathology; D012812:Sigmoidoscopy / Q000379:methods