High performance liquid chromatography enantioseparation of chiral pharmaceuticals using tris(chloro-methylphenylcarbamate)s of cellulose.
Chiral recognition abilities of a recently developed new type of cellulose phenylcarbamates were studied. These chiral stationary phases (CSPs) simultaneously contain both electron-withdrawing (Cl) and electron-donating (CH3) substituents on the phenyl moiety. Chiral pharmaceuticals which belong to the various pharmacological groups (sedatives, hypnotics, anticonvulsants, Ca2+ channel blockers, beta-blockers, antitusives, antihystaminics, choleretics, diuretics, antimycotics, etc) were resolved to enantiomers. These new CSPs sometimes exhibit alternative chiral recognition ability to that most successful commercially available cellulosic CSP Chiralcel-OD and can be used as a good complement to it in analytical and preparative scale enantioseparations.
Chankvetadze
B
B
Department of Chemistry, Tbilisi State University, Georgia.
Chankvetadze
L
L
Sidamonidze
S
S
Yashima
E
E
Okamoto
Y
Y
D000319:Adrenergic beta-Antagonists / Q000032:analysis; D014151:Anti-Anxiety Agents / Q000032:analysis; D000935:Antifungal Agents / Q000032:analysis; D001463:Barbiturates / Q000032:analysis; D001569:Benzodiazepines / Q000032:analysis; D002219:Carbamates; D002482:Cellulose / Q000031:analogs & derivatives*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004095:Dihydropyridines / Q000032:analysis; D006634:Histamine H1 Antagonists / Q000032:analysis; D006993:Hypnotics and Sedatives / Q000032:analysis; D007093:Imidazoles / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011412:Propanolamines / Q000032:analysis; D011725:Pyridines / Q000032:analysis; D013237:Stereoisomerism; D014665:Vasodilator Agents / Q000032:analysis
D000319:Adrenergic beta-Antagonists; D014151:Anti-Anxiety Agents; D000935:Antifungal Agents; D001463:Barbiturates; D002219:Carbamates; D004095:Dihydropyridines; D006634:Histamine H1 Antagonists; D006993:Hypnotics and Sedatives; D007093:Imidazoles; D004364:Pharmaceutical Preparations; D011412:Propanolamines; D011725:Pyridines; D014665:Vasodilator Agents; D001569:Benzodiazepines; D002482:Cellulose