title: Short strong hydrogen bonds: can they explain enzymic catalysis?
abstract: It has been proposed that some remarkable enzymic catalytic effects can be explained by the existence of unusually strong hydrogen bonds within the enzyme's active site. Although such hydrogen bonds may be short, and may have unusual properties, there is no evidence that unusually strong hydrogen bonds exist in solution or in enzyme active sites. Thus there is no basis for invoking strong hydrogen bonds to explain enzymic rate enhancements.
authors.affiliation: Department of Chemistry, University of Western Ontario, London, Ontario N6A 5B7, Canada.
authors.forename: J P
authors.initials: JP
authors.lastname: Guthrie
mesh_terms: D002384:Catalysis; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism*; D006860:Hydrogen Bonding
chemical_list: D004798:Enzymes