Two steps to binding replication origins? DNA-protein interactions.
Recent structural studies of the Epstein-Barr virus EBNA1 protein bound to DNA suggest that it binds to DNA replication origins in a two-step process; the first step involves recognition of the correct sequence and the second initiates structural changes in the DNA.
Dean
F B
FB
Microbiology Department, Hearst Research Foundation and Howard Hughes Medical Institute, Cornell University Medical College, 1300 York Avenue, New York, New York 10021, USA.
O'Donnell
M
M
D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D019309:Epstein-Barr Virus Nuclear Antigens / Q000737:chemistry / Q000378:metabolism*; D009690:Nucleic Acid Conformation; D011485:Protein Binding; D011487:Protein Conformation; D018741:Replication Origin
D004268:DNA-Binding Proteins; D019309:Epstein-Barr Virus Nuclear Antigens; D004247:DNA