Spinal MRI in progressive myeloneuropathy associated with vitamin E deficiency.
We describe a patient with a progressive neurological disorder consisting of ataxia, loss of proprioception and pyramidal tract dysfunction in his sixth decade. He had severe vitamin E deficiency due to fat malabsorption secondary to chronic inflammatory bowel disease. Sural nerve biopsy revealed a reduced number of myelinated fibres. MRI of the cervical spine showed high-signal lesions on T2-weighted images in the posterior columns, correlating well with the clinical findings.
Vorgerd
M
M
Department of Neurology, Ruhr University Bochum, BG-Kliniken Bergmannsheil, Germany.
Tegenthoff
M
M
Kühne
D
D
Malin
J P
JP
D001706:Biopsy; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000209:etiology; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis; D013116:Spinal Cord / Q000473:pathology*; D013118:Spinal Cord Diseases / Q000175:diagnosis; D013497:Sural Nerve / Q000473:pathology; D014811:Vitamin E Deficiency / Q000150:complications*