High performance thin layer chromatographic analysis of hydrolyzed tinidazole solutions. II. Hydrolysis kinetics of tinidazole.
In a citrate-borate-phosphate buffer, 5 mM tinidazole solutions exhibited maximum stability stability around pH 4.0-5.0. The hydrolysis of tinidazole was mostly a first-order reaction. At pH 10.0 and 60-80 degrees C, tinidazole had an activation energy of 122 kJ mol-1 for hydrolysis. It was postulated that tinidazole decomposes by different mechanisms under basic and neutral/acidic conditions.
Salo
J P
JP
Department of Pharmacy, University of Helsinki, Finland.
Salomies
H
H
D000994:Antitrichomonal Agents / Q000032:analysis* / Q000737:chemistry; D002855:Chromatography, Thin Layer; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007700:Kinetics; D012996:Solutions; D014011:Tinidazole / Q000032:analysis* / Q000737:chemistry
D000994:Antitrichomonal Agents; D012996:Solutions; D014011:Tinidazole