title: Force: a new structural control parameter?
abstract: Recent technical developments that allow precise force measurements on single molecules, together with numerical simulations of biomolecules under stress, offer new insight into how stress affects molecular interactions, and how large the force developed by a travelling enzyme such as RNA polymerase can be.
authors.affiliation: Laboratoire de Physique Statistique, ENS, URA D1306 CNRS, 24 rue Lhomond, 75231 Paris Cedex, France. david@physique.ens.fr
authors.forename: D
authors.initials: D
authors.lastname: Bensimon
mesh_terms: D000818:Animals; D001360:Avidin / Q000737:chemistry / Q000378:metabolism; D001710:Biotin / Q000737:chemistry / Q000378:metabolism; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004278:DNA, Superhelical / Q000737:chemistry / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D004548:Elasticity; D006801:Humans; D006860:Hydrogen Bonding; D008024:Ligands; D008956:Models, Chemical; D008958:Models, Molecular; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism; D012399:Rotation; D013314:Stress, Mechanical
chemical_list: D004278:DNA, Superhelical; D008024:Ligands; D011956:Receptors, Cell Surface; D001360:Avidin; D001710:Biotin; D004247:DNA; D012321:DNA-Directed RNA Polymerases