The effect of muscarinic and nicotinic ACh antagonist on the facilitation of rat visual cortical responses.
Combined blockade of both muscarinic and nicotinic receptors fully eliminated the effect of reticular facilitation in rat visual cortex. However, this effect lasted only 2 h, what can suggest that there may be other excitatory input to the cholinergic neurones in rat visual cortex which is activated after blockade of cholinergic transmission.
Lewandowski
M H
MH
Department of Animal Physiology, Jagiellonian University, Kraków, Poland. lew@zuk.iz.uj.edu.pl
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D008297:Male; D008464:Mecamylamine / Q000494:pharmacology; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D018733:Nicotinic Antagonists / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012154:Reticular Formation / Q000187:drug effects*; D012601:Scopolamine / Q000494:pharmacology; D014793:Visual Cortex / Q000187:drug effects*
D018727:Muscarinic Antagonists; D018733:Nicotinic Antagonists; D008464:Mecamylamine; D001285:Atropine; D012601:Scopolamine