title: Spatial reversal learning in preclinical scrapie-inoculated mice.
abstract: Acquisition and reversal of a two-choice spatial discrimination were tested in scrapie-inoculated mice. Both acquisition and reversal were normal in mice tested 138 and 103 days prior to the onset of clinical symptoms. At 65 days before onset of clinical symptoms, scrapie-inoculated mice required more trails to criterion in reversal learning, but this effect was not significant in a second experiment (68 days preclinical) and was transient: no effect was seen 33 days before symptoms. However, the course of reversal learning was abnormal in all three late preclinical groups (68, 65 and 33 days before symptoms). Reversal learning in these three groups was characterized by a rapid extinction of the original discrimination, followed by a period, absent in controls, during which performance showed no further improvement. This effect corresponds in time of onset to the appearance of characteristic neuropathological features.
authors.affiliation: Department of Psychology, University of Wales Swansea, UK.
authors.forename: A M
authors.initials: AM
authors.lastname: Lysons
authors.forename: S J
authors.initials: SJ
authors.lastname: Woollard
mesh_terms: D000818:Animals; D005260:Female; D007274:Injections, Intraperitoneal; D018782:Maze Learning / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains; D012608:Scrapie / Q000523:psychology*; D013037:Spatial Behavior / Q000502:physiology*