title: Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease.
abstract: We have studied the relationship between the apolipoprotein E gene (APOE) and the development of myoclonus, tremors, rigidity and seizures in 168 patients with probable early-onset Alzheimer's disease (AD). There was a statistically significantly lower risk of tremor for carriers of the epsilon 4 allele of APOE. This allele was also associated with an increased risk of myoclonus. Our findings suggest that there may be differences in progression and clinical appearance in early-onset AD related to the APOE genotype.
authors.affiliation: Department of Epidemiology & Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Bronzova
authors.forename: C M
authors.initials: CM
authors.lastname: van Duijn
authors.forename: L M
authors.initials: LM
authors.lastname: Havekes
authors.forename: P
authors.initials: P
authors.lastname: de Knijff
authors.forename: C
authors.initials: C
authors.lastname: Van Broeckhoven
authors.forename: A
authors.initials: A
authors.lastname: Hofman
mesh_terms: D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology; D001053:Apolipoproteins / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D001053:Apolipoproteins