Familial hiatus hernia and gastro-oesophageal reflux.
This report describes a family in which the father and three children had a sliding hiatus hernia. In each case there was gastro-oesophageal reflux from the neonatal period which proved unresponsive to medical therapy, ultimately requiring anti-reflux surgery. The trait in this family supports an autosomal dominant genetic component to the infant hiatus hernia.
Chana
J
J
Department of Paediatric Surgery, Hospital for Sick Children, London, UK.
Crabbe
D C
DC
Spitz
L
L
D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D004942:Esophagitis, Peptic / Q000175:diagnosis / Q000235:genetics / Q000601:surgery; D005260:Female; D018662:Fundoplication; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D005799:Genes, Dominant / Q000235:genetics*; D006551:Hernia, Hiatal / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011183:Postoperative Complications / Q000209:etiology / Q000601:surgery; D011706:Pyloric Antrum / Q000601:surgery; D012086:Reoperation