A bilateral model integrating vergence and the vestibulo-ocular reflex.
The majority of previous modelling studies of vergence and the vestibulo-ocular reflex (VOR) have postulated arbitrary structures mainly on the basis of input-output behavioural relationships. Such models were developed following traditional schemes of oculomotor organization, based upon the notion of independence between different oculomotor subsystems. This impedes the simulation of complex binocular interactions and associated central activities. In contrast to preceding studies, the mathematical model for binocular control presented here was developed fully on physiological and anatomical grounds which reflect the organization and functional properties of known vergence and VOR premotor centres. Computer simulations show the model properly simulates the main observed characteristics in the discharge of several premotor and motor nuclei during slow vergence and the VOR in the dark. In particular, the model reproduces the activity profiles of abducens internuclear neurons, secondary vestibular cells, tonic prepositus hypoglossi neurons and ocular motoneurons during vergence and the VOR. It also simulates the activity of mesencephalic neurons whose discharge is modulated by vergence parameters alone. It is shown that given recent neurophysiological and behavioural findings, ocular reflexes cannot be properly modelled as separate independent subsystems whereas a single, unified modelling approach can produce results consistent with observed data. This study also shows how changes in the functional activity of shared pathways in a single two-sided structure produce vergence and conjugate integrators whose function relies on coupled loops across the brainstem: separate, dedicated operators are not necessary to replicate data. This provides evidence that challenges previous studies supporting the existence of separate vergence and conjugate integrators to transform velocity to position signals in the brainstem. A major implication of this study is that it questions the validity of testing conjugate and vergence systems independently, neglecting potential interactions.
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Department of Biomedical Engineering, McGill University, Montréal, Canada.
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D003198:Computer Simulation; D003290:Convergence, Ocular / Q000502:physiology*; D005133:Eye Movements / Q000502:physiology; D005403:Fixation, Ocular / Q000502:physiology; D006257:Head / Q000502:physiology; D007002:Hypoglossal Nerve / Q000502:physiology; D008959:Models, Neurological; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology*; D014726:Vestibular Nuclei / Q000502:physiology; D015348:Vision, Binocular / Q000502:physiology