Base eversion and shuffling by DNA methyltransferases.
The structures of two DNA cytosine methyltransferases reveal two novel methods of gaining access to the substrate cytosine residue, both of which involve eversion of the cytosine in a process that may require DNA bending. In one instance there is also widespread base shuffling and distortion of the DNA.
Nelson
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HC
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Bestor
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TH
D015254:DNA Modification Methylases / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular
D015254:DNA Modification Methylases