title: Long-term hemodynamic effects of portocaval shunt and Sugiura procedure in patients with cirrhosis.
abstract: Systemic and splanchnic hemodynamics were studied before and six months after a portal systemic shunt (n = 6) or a Sugiura procedure (n = 9) in 15 patients with cirrhosis and a past history of variceal bleeding. Hepatic blood flow was estimated by hepatic extraction and clearance of continuous indocyanine green infusion. Azygos blood flow was measured with a continuous thermodilution catheter. After portocaval shunt, the cardiac index increased significantly from 4.0 +/- .4 to 5.4 +/- 0.8 l/min m2 (p < 0.05), the hepatic venous pressure gradient and hepatic blood flow were significantly decreased from 21 +/- 3 to 13 +/- 5 mm Hg (p < 0.05) and from 1.20 +/- 0.35 to 0.37 +/- 0.16 l/min (p < 0.05) respectively. The decrease in azygos blood flow was not significant (0.51 +/- 0.31 vs 0.25 +/- 0.33 l/min; p = 0.1). After Sugiura procedure, there was no significant change in cardiac index, hepatic venous pressure gradient, hepatic blood flow or azygos blood flow. This is the first study to show the long-term maintenance of splanchnic and systemic hemodynamics in patients with cirrhosis after Sugiura procedure. The absence of long-term hemodynamic alterations could explain the absence of encephalopathy after this procedure.
authors.affiliation: Groupe de Recherche sur la Chirurgia du Foie et de l'Hypertension Portale, Hôpital Antoine Béclère, France.
authors.forename: C
authors.initials: C
authors.lastname: Vons
authors.forename: A
authors.initials: A
authors.lastname: Hadengue
authors.forename: C
authors.initials: C
authors.lastname: Smadja
authors.forename: D
authors.initials: D
authors.lastname: Franco
authors.forename: D
authors.initials: D
authors.lastname: Lebrec
mesh_terms: D001401:Azygos Vein / Q000503:physiopathology; D001783:Blood Flow Velocity; D001794:Blood Pressure; D002302:Cardiac Output; D004932:Esophageal and Gastric Varices / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D008102:Liver Circulation; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications / Q000503:physiopathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011167:Portacaval Shunt, Surgical; D011446:Prospective Studies; D013152:Splanchnic Circulation; D014655:Vascular Resistance