title: Demonstration of late cardiotoxicity following bone marrow transplantation by assessment of exercise diastolic filling characteristics.
abstract: We evaluated the role of rest and exercise left ventricular diastolic filling parameters as a marker of cardiotoxicity in 25 consecutive patients 1 year following BMT. Ten age- and sex-matched subjects served as controls. Patients were evaluated in toto and in three sub-groups according to chemotherapy. Left ventricular ejection fraction (EF), peak filling rate (PFR) and time to peak filling (TTPF) were assessed at rest and at peak exercise. EF and PFR were similar at rest and at peak exercise in patients and controls. TTPF was significantly prolonged at rest in patients compared to controls (200 +/- 65 vs 131 +/- 26 ms, P = 0.003) and at peak exercise was markedly longer in patients (142 +/- 40 vs 54 +/- 19 ms, P < 0.001). Sub-group analysis demonstrated abnormal resting TTPF in those patients who had received either combination anthracycline and CY or anthracycline and melphalan, while those patients who received CY alone had normal resting TTPF. However, exercise TTPF was abnormally prolonged in all patient groups. While all controls demonstrated a normal decrease in TTPF during exercise, four of the 25 patients had a paradoxical increase in TTPF during exercise. Exercise diastolic function may provide evidence of cardiotoxicity in long-term survivors of BMT.
authors.affiliation: Department of Cardiology, Royal Brisbane Hospital, Australia.
authors.forename: S S
authors.initials: SS
authors.lastname: Lele
authors.forename: S T
authors.initials: ST
authors.lastname: Durrant
authors.forename: J J
authors.initials: JJ
authors.lastname: Atherton
authors.forename: T D
authors.initials: TD
authors.lastname: Moore
authors.forename: H L
authors.initials: HL
authors.lastname: Thomson
authors.forename: F A
authors.initials: FA
authors.lastname: Khafagi
authors.forename: M P
authors.initials: MP
authors.lastname: Frenneaux
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000494:pharmacology; D003971:Diastole; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019172:Transplantation Conditioning; D016277:Ventricular Function, Left
chemical_list: D003520:Cyclophosphamide