title: Role of neurotrophic factors in neuronal development.
abstract: The spectrum of potential biological roles for neurotrophic factors in development and maturation of the nervous system continues to widen. Careful analysis of the phenotypes of knock-out mice has been used to test directly the 'neurotrophic hypothesis', and the role of members of the transforming growth factor beta superfamily--in particular, glial cell line derived neurotrophic factor--in regulating neuronal survival has become apparent. The effects of neurotrophin-3 on early neuronal differentiation and maturation have proved to be both multiple and complex. Neurotrophic factors are also emerging as potential regulators of synapse stabilization and function.
authors.affiliation: INSERM U.382, Developmental Biology Institute of Marseille (IBDM), CNRS-INSERM Université de la Méditerranée, Campus de Liminy, France. chris@ibdm.univ-mrs.fr
authors.forename: C E
authors.initials: CE
authors.lastname: Henderson
mesh_terms: D000818:Animals; D051379:Mice; D009414:Nerve Growth Factors / Q000502:physiology*; D009420:Nervous System / Q000254:growth & development*; D013569:Synapses / Q000502:physiology*
chemical_list: D009414:Nerve Growth Factors