Serum IgE concentration and other immune manifestations of treatment with gold salts are linked to the MHC and IL4 regions in the rat.
A subset of patients with rheumatoid arthritis occasionally develops skin reactions and glomerulonephritis and exhibits an increase in serum IgE concentration when treated with gold salts. Brown-Norway (BN) rats injected with aurothiopropanolsulfonate (ATPS) also manifest an autoimmune glomerulonephritis and increased serum IgE concentration, whereas Lewis (LEW) rats are resistant to complications. Here, we show linkage between responses to ATPS in a (BN x LEW) F2 cohort and the major histocompatibility complex (RT1) on rat chromosome 20 and between markers in the region of IL4 and other candidate genes on rat chromosome 10. Recently, human serum IgE concentration has been reported to be linked to the IL-4 region. Taken together, these findings raise the possibility that homologous genes could be implicated in ATPS manifestations in the rat and in the regulation of IgE levels in the human.
Kermarrec
N
N
INSERM U28 Hôpital Broussais, Paris, France.
Dubay
C
C
De Gouyon
B
B
Blanpied
C
C
Gauguier
D
D
Gillespie
K
K
Mathieson
P W
PW
Druet
P
P
Lathrop
M
M
Hirsch
F
F
D000818:Animals; D018501:Antirheumatic Agents / Q000633:toxicity*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000235:genetics / Q000276:immunology; D001483:Base Sequence; D003433:Crosses, Genetic; D017931:DNA Primers / Q000235:genetics; D004112:Dimercaprol / Q000031:analogs & derivatives* / Q000633:toxicity; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005921:Glomerulonephritis / Q000139:chemically induced; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D015847:Interleukin-4 / Q000235:genetics*; D008285:Major Histocompatibility Complex; D008297:Male; D008969:Molecular Sequence Data; D050607:Organogold Compounds; D009942:Organometallic Compounds / Q000633:toxicity*; D020005:Propanols; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D012867:Skin / Q000187:drug effects / Q000276:immunology; D013438:Sulfhydryl Compounds
D018501:Antirheumatic Agents; D017931:DNA Primers; D005819:Genetic Markers; D050607:Organogold Compounds; D009942:Organometallic Compounds; D020005:Propanols; D013438:Sulfhydryl Compounds; D004112:Dimercaprol; D015847:Interleukin-4; D007073:Immunoglobulin E; C013394:aurotioprol