Acute encephalopathy attributed to 5-FU.
Acute encephalopathy attributable to 5-fluorouracil (5-FU) is rare. A patient experienced this reaction associated with a continuous 5-FU infusion. The etiology of the event remains uncertain, but it is generally reversible and does not preclude retreatment with 5-FU at reduced dosages. Steroids and thiamine may expedite neurologic recovery.
Langer
C J
CJ
Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Hageboutros
A
A
Kloth
D D
DD
Roby
D
D
Shaer
A H
AH
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D001921:Brain / Q000187:drug effects*; D001927:Brain Diseases / Q000139:chemically induced; D002526:Cerebellar Diseases / Q000139:chemically induced; D002531:Cerebellum / Q000187:drug effects; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil