title: High dose of intravenous antithrombin III without heparin in the treatment of disseminated intravascular coagulation and organ failure in four children.
abstract: In several animal experiments, high doses of antithrombin III concentrates have shown beneficial effects on mortality and reversal of coagulation abnormalities which had resulted from disseminated intravascular coagulation. Other experiments have suggested that antithrombin III infusion without heparin is effective in the treatment of organ failure. We clinically treated children suffering disseminated intravascular coagulation only with antithrombin concentrate. Four patients suffering disseminated intravascular coagulation with organ failure were selected. We started antithrombin III concentrate infusion as soon as the diagnosis was established. The dosage of antithrombin III was 120-250 units/kg/day for 2 or 3 days. Heparin was not used. All 4 patients recovered completely and quickly without any complications within 14 days. We suggest that the high-dose antithrombin III infusion without heparin is an effective and safe therapy for disseminated intravascular coagulation with organ failure.
authors.affiliation: Department of Pediatrics, Sapporo Medical University School of Medicine, Hokkaido, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Fuse
authors.forename: H
authors.initials: H
authors.lastname: Tomita
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: T
authors.initials: T
authors.lastname: Hori
authors.forename: C
authors.initials: C
authors.lastname: Igarashi
authors.forename: S
authors.initials: S
authors.lastname: Fujita
mesh_terms: D000990:Antithrombin III / Q000008:administration & dosage*; D004211:Disseminated Intravascular Coagulation / Q000150:complications* / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008297:Male; D009102:Multiple Organ Failure / Q000150:complications*; D015842:Serine Proteinase Inhibitors / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D015842:Serine Proteinase Inhibitors; D000990:Antithrombin III