Serial position and temporal cue effects in multiple sclerosis: two subtypes of defective memory mechanisms.
Neurocognitive studies of multiple sclerosis (MS) have identified a robust long-term memory deficit. We hypothesized that this is due in part to the limited representation and use of serial order information. MS patients and controls were studied with a supraspan list learning procedure with post-encoding retrieval and recognition trials. MS patients demonstrated post-encoding negative recency with normal recognition, and word order recall was impaired. These findings appear to be in part to difficulty using temporal order cues in long-term memory. Two dissociable memory deficits were identified, suggesting that there are at least two neurocognitive mechanisms underlying memory impairment in MS.
Armstrong
C
C
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104-4283, USA. armstrong@shy.neuro.upenn.edu
Onishi
K
K
Robinson
K
K
D'Esposito
M
M
Thompson
H
H
Rostami
A
A
Grossman
M
M
D000328:Adult; D006801:Humans; D008569:Memory Disorders / Q000150:complications* / Q000175:diagnosis; D009103:Multiple Sclerosis / Q000150:complications*; D013647:Task Performance and Analysis; D013997:Time Factors