YM-24074, a new peptide antibiotic. II. Structural elucidation.
YM-24074 (formerly called YL-01869P) is a new antibiotic and type I collagenase inhibitor. The structure of this compound was elucidated by spectroscopic analysis and confirmed by acid degradation to be N-(1"-acetyl-3"-methylbutyl)-2- [2'-[(N-hydroxycarbamoyl)methyl]heptanoyl]-hexahydropyrid azine-3-carboxamide. The stereochemistry of two of three chiral centers was determined by degradation products to be 3S, 2'R.
Sato
T
T
Analytical Science Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Shizuoka Prefecture, Japan.
Takebayashi
Y
Y
Tokunaga
T
T
Ozasa
T
T
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010455:Peptides; D011724:Pyridazines / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D010455:Peptides; D011724:Pyridazines; C092181:YL 01869P