title: Arisugacins A and B, novel and selective acetylcholinesterase inhibitors from Penicillium sp. FO-4259. II. Structure elucidation.
abstract: The structures of new acetylcholinesterase inhibitors, arisugacins A and B, were elucidated by NMR study. Arisugacins have a (4aR,6aR,12aS,12bS)-4a,6,6a,12,12a, 12b-hexahydro-4a,12a-dihydroxy-4,4,6a,12b-tetramethyl-4H,11H -naphtho[2,1-b] pyrano[3,4-e]pyran-1,11(5H)-dione moiety in common and 3,4-dimethoxyphenyl or 4-methoxyphenyl residues are attached to C-9 of the moiety.
authors.affiliation: Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Kuno
authors.forename: K
authors.initials: K
authors.lastname: Shiomi
authors.forename: K
authors.initials: K
authors.lastname: Otoguro
authors.forename: T
authors.initials: T
authors.lastname: Sunazuka
authors.forename: S
authors.initials: S
authors.lastname: Omura
mesh_terms: D002800:Cholinesterase Inhibitors / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010407:Penicillium / Q000378:metabolism*; D011714:Pyrans / Q000737:chemistry*
chemical_list: D002800:Cholinesterase Inhibitors; D011714:Pyrans; C095353:arisugacin