title: Serum haptoglobin concentration in growing swine after intranasal challenge with Bordetella bronchiseptica and toxigenic Pasteurella multocida type D.
abstract: The acute phase reaction, in association with progressive atrophic rhinitis (AR), was monitored for 3 wk using serum haptoglobin (HPT) quantification in thirty-six, 15 kg swine after intranasal challenge with varying doses of Pasteurella multocida type D (toxigenic strain) and Bordetella bronchiseptica. The challenge doses were administered alone or in combination with pigs divided into 9 isolated treatment groups. Increasing doses of B. bronchiseptica were associated with lower serum HPT (P < 0.05), whereas increasing doses of P. multocida tended to increase serum HPT (0.05 < P < 0.10). Significant and positive correlation of mean HPT and AR score was found in these pigs; increased AR scores were associated with elevated mean HPT concentration (r = 0.41, P < 0.01). A significant interaction between P. multocida and B. bronchiseptica dose indicated that increasing the dose of B. bronchiseptica, for a fixed P. multocida dose, was associated with less AR (P < 0.05). The AR scores were greater in pigs given P. multocida, than B. bronchiseptica alone. These results indicate that a complex interaction between Pasteurella multocida and Bordetella bronchiseptica causes progressive atrophic rhinitis and alters serum HPT concentration in swine.
authors.affiliation: Department of Veterinary Clinical medicine, College of Veterinary Medicine, University of Illinois, Urbana 61801, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Francisco
authors.forename: T R
authors.initials: TR
authors.lastname: Shryock
authors.forename: D P
authors.initials: DP
authors.lastname: Bane
authors.forename: L
authors.initials: L
authors.lastname: Unverzagt
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D001885:Bordetella Infections / Q000097:blood / Q000150:complications / Q000662:veterinary*; D016950:Bordetella bronchiseptica / Q000502:physiology*; D005260:Female; D006242:Haptoglobins / Q000032:analysis*; D010326:Pasteurella Infections / Q000097:blood / Q000150:complications / Q000662:veterinary*; D016979:Pasteurella multocida / Q000502:physiology*; D012222:Rhinitis, Atrophic / Q000209:etiology / Q000382:microbiology / Q000662:veterinary; D013552:Swine / Q000097:blood* / Q000254:growth & development*; D013553:Swine Diseases / Q000097:blood*
chemical_list: D006242:Haptoglobins