Pseudotumor cerebri associated with cyclosporine use.
OBJECTIVE
An 11-year-old boy had a one-month history of horizontal diplopia. Three years earlier, he had undergone allogeneic bone marrow transplantation complicated by graft versus host disease.


METHODS
The patient had esotropia and bilateral optic disk edema. A magnetic resonance imaging scan disclosed no intracranial lesion. The opening pressure of the lumbar puncture was 500 mm of water. Pseudotumor cerebri secondary to cyclosporine was diagnosed.


RESULTS
The patient improved with resolution of his esotropia and diplopia within five days of discontinuing his cyclosporine. The optic disk edema resolved within three months.


CONCLUSIONS
Cyclosporine must be added to the list of medications with a known association with pseudotumor cerebri.
Cruz
O A
OA
Anheuser-Busch Eye Institute, St. Louis University School of Medicine, MO, USA. CRUZOA@SLUVCA.SLV.EDU
Fogg
S G
SG
Roper-Hall
G
G
D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002648:Child; D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D004172:Diplopia / Q000139:chemically induced; D004948:Esotropia / Q000139:chemically induced; D006086:Graft vs Host Disease / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D007427:Intracranial Pressure; D008297:Male; D010211:Papilledema / Q000139:chemically induced; D011559:Pseudotumor Cerebri / Q000139:chemically induced*; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D016572:Cyclosporine