Chromosomal localization of the mouse Src-like adapter protein (Slap) gene and its putative human homolog SLA.
Molecules containing Src-homology 2 (SH2) and Src-homology 3 (SH3) domains are critical components of signal transduction pathways that serve to relay signals originating from the cell surface to the interior of the cell. Src-like adapter protein (SLAP) is a recently described adapter protein that binds activated the Eck receptor protein-tyrosine kinase. Although SLAP bears a striking homology to the SH3 and SH2 domains of the Src family of nonreceptor tyrosine kinases, it does not contain a tyrosine kinase catalytic domain. In this report, the Slap gene was mapped by linkage analysis to mouse chromosome 15, while its putative human homolog (SLA) was identified and mapped to human 8q22.3-qter using a panel of somatic cell hybrids.
Angrist
M
M
Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106-4955, USA.
Wells
D E
DE
Chakravarti
A
A
Pandey
A
A
D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D016392:Proto-Oncogene Proteins pp60(c-src) / Q000235:genetics*; D012377:Rodentia; D017386:Sequence Homology, Amino Acid
D048868:Adaptor Proteins, Signal Transducing; C490635:SLA protein, human; C095148:Sla protein, mouse; D004247:DNA; D016392:Proto-Oncogene Proteins pp60(c-src)