Histamine receptors and bioeffects on clonal parathyroid endothelial cells.
Using a clonal line of bovine parathyroid endothelial cells (BPE-1) we defined the presence on these cells of a histamine H2 receptor and characterized its pharmacological properties. Interaction of histamine with its receptor induced an increase of cAMP accumulation in a dose- and time-dependent fashion. This effect appears unique for parathyroid endothelial cells, in fact, clonal parathyroid epithelial cells did not exhibit a similar response. No effect of histamine was observed on BPE-1 cell proliferation.
Frediani
U
U
Dipartimento di Fisiopatologia Clinica e, University of Firenze, Italy.
Benvenuti
S
S
Masi
L
L
Tanini
A L
AL
Brandi
M L
ML
D000818:Animals; D002417:Cattle; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis; D017259:Dimaprit / Q000031:analogs & derivatives / Q000378:metabolism; D004727:Endothelium / Q000166:cytology / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D007457:Iodine Radioisotopes; D007700:Kinetics; D010280:Parathyroid Glands / Q000166:cytology* / Q000378:metabolism; D011970:Receptors, Histamine H2 / Q000502:physiology*
D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D007457:Iodine Radioisotopes; D011970:Receptors, Histamine H2; C071989:APT; D006632:Histamine; D004247:DNA; D000242:Cyclic AMP; D017259:Dimaprit