[Effect of aprotinin on endothelial cell functions during cardiopulmonary bypass].
Fourteen patients undergoing cardiac or great vessel surgery using cardiopulmonary bypass (ECC) were divided into two groups. Group A of 7 patients received 2 x 10(6) units of aprotinin (apr) 15 min before ECC and 0.5 x 10(6) unit immediately after the ECC. Group B of 7 patients received 0.5 x 10(6) unit of aprotinin 15 min before ECC and 2 x 10(6) units immediately after the ECC. Several physiological parameters were measured two hours before ECC, immediately after the cessation of the ECC and 4 hours thereafter. No difference was noted in coagulation time, which remained within normal range, and postoperative hemorrhage between the groups after ECC. Although thrombomodulin, ELAM-1 and ICAM-1 tended to decrease slightly in the two groups immediately after ECC, recovery of the thrombomodulin was much more rapid in the A group than in the B group. On the other hand, blood endothelin level and von Willebrand factor activity were elevated progressively after the ECC. Blood granulocyte-elastase activity and IL-8 increased markedly immediately after the ECC and then tended to decrease. These data indicate that no marked damage would be caused on the endothelial cells during ECC which was carried out using a relatively small dose of apr. However, the protective effect of apr remained to be clarified in the future.
Takaori
M
M
Department of Anesthesiology, Kawasaki Medical School, Kurashiki.
Fukui
A
A
Kimura
K
K
Mihira
M
M
Fujiwara
T
T
D000328:Adult; D000368:Aged; D007611:Aprotinin / Q000008:administration & dosage* / Q000494:pharmacology; D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D002318:Cardiovascular Diseases / Q000097:blood / Q000601:surgery; D004305:Dose-Response Relationship, Drug; D019040:E-Selectin / Q000097:blood; D019332:Endothelin-1 / Q000097:blood; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D019106:Postoperative Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D018180:Thrombomodulin / Q000097:blood; D014841:von Willebrand Factor / Q000032:analysis
D019040:E-Selectin; D019332:Endothelin-1; D016209:Interleukin-8; D018180:Thrombomodulin; D014841:von Willebrand Factor; D018799:Intercellular Adhesion Molecule-1; D007611:Aprotinin