Purpurins and benzochlorins as sensitizers for photodynamic therapy.
Purpurins and benzochlorins are hydrophobic second generation photosensitizers, which have sizable absorption in the 650-780 nm range and exhibit photodynamic activity against tumors after visible light treatment. This review summarizes the published data regarding these compounds: from the spectroscopic, photophysical and photochemical characteristics to the in vivo and in vitro photodynamic inactivation of tumors and normal tissue effects. Some mechanistic studies using both the Sn-etiopurpurin and/or the Cu-benzochlorin derivatives are also reviewed.
Garbo
G M
GM
Department of Chemistry, University of Toledo, OH 43606, USA.
D000818:Animals; D000880:Anthraquinones; D004333:Drug Administration Routes; D006801:Humans; D037102:Lectins / Q000737:chemistry / Q000627:therapeutic use*; D010777:Photochemistry; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000627:therapeutic use*; D011166:Porphyrins / Q000737:chemistry / Q000627:therapeutic use*
D000880:Anthraquinones; D037102:Lectins; D017319:Photosensitizing Agents; D011166:Porphyrins; C006969:chlorin; C511975:purpurin anthraquinone