title: Transcriptional regulation in the obligate intracytoplasmic bacterium Rickettsia prowazekii.
abstract: Transcriptional regulation was demonstrated in Rickettsia prowazekii, an obligate intracytoplasmic bacterium. The level of citrate synthase (gltA) mRNA II, from promoter P2, was greater in the total RNA isolated from heavily infected L929 cells than in moderately infected L929 cells; conversely, the level of ATP/ADP translocase (tlc) mRNA was greater in moderately infected cells. The level of gltA mRNA I, from promoter P1, did not change under these conditions. The chemical half-lives of gltA mRNA II and tlc mRNA under these conditions were very similar.
authors.affiliation: Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile 36688, USA.
authors.forename: J
authors.initials: J
authors.lastname: Cai
authors.forename: H H
authors.initials: HH
authors.lastname: Winkler
mesh_terms: D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D002950:Citrate (si)-Synthase / Q000096:biosynthesis; D015964:Gene Expression Regulation, Bacterial; D006207:Half-Life; D051379:Mice; D000226:Mitochondrial ADP, ATP Translocases / Q000096:biosynthesis; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D012329:RNA, Bacterial / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D012283:Rickettsia prowazekii / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D012329:RNA, Bacterial; D012333:RNA, Messenger; D000226:Mitochondrial ADP, ATP Translocases; D002950:Citrate (si)-Synthase