title: The impact of cocaine on plasma growth hormone levels in the adult male rat.
abstract: Little is known about the neuroendocrine impact of cocaine as it relates to pituitary growth hormone secretion. In these studies, in adult male rats, intracerebroventricular administration of cocaine caused a potent dose-related suppression of circulating growth hormone (GH) in animals sacrificed 15 min after drug administration. We conclude that in the adult male rat cocaine suppresses plasma GH levels.
authors.affiliation: Research Service, Department of Veterans Affairs Hospital, Hines, IL 60141, USA.
authors.forename: N V
authors.initials: NV
authors.lastname: Emanuele
authors.forename: A D
authors.initials: AD
authors.lastname: Levey
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.forename: L
authors.initials: L
authors.lastname: Kirsteins
authors.forename: L D
authors.initials: LD
authors.lastname: Van de Kar
mesh_terms: D000818:Animals; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D013006:Growth Hormone / Q000097:blood*; D007700:Kinetics; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D013006:Growth Hormone; D003042:Cocaine