title: Effect of thalamic stimulation on gait in Parkinson disease.
abstract: OBJECTIVE
  To assess the influence of ventral intermediate thalamic nucleus stimulation on gait in idiopathic Parkinson disease.
  
  
  METHODS
  Clinical and physiological assessments were compared in patients with and without ventral intermediate thalamic nucleus stimulation.
  
  
  METHODS
  The research clinic of a university department of gait analysis.
  
  
  METHODS
  Seven patients with idiopathic Parkinson disease who had long-term monopolar stimulation of the ventral intermediate thalamic nucleus to control a large-amplitude tremor.
  
  
  METHODS
  Gait kinematic parameters were autonomically recorded using the Vicon optoelectric system for movement analysis. Measures of locomotor displacement (cadence, walking speed, stride and step times, single and double support times, and stride and step lengths) were computed successfully during 2 conditions: stimulation on and off. Traces of ankle joint position were also analyzed for the left and right lower limbs and for the affected and unaffected lower limbs.
  
  
  RESULTS
  No difference in mean values was observed between the 2 conditions.
  
  
  CONCLUSIONS
  This study seems to confirm that ventral intermediate thalamic nucleus stimulation, effective in reducing tremor, does not modify gait parameters in idiopathic Parkinson disease.
authors.affiliation: Department of Gait Analysis, University of Lille, Lille, France.
authors.forename: L
authors.initials: L
authors.lastname: Defebvre
authors.forename: J L
authors.initials: JL
authors.lastname: Blatt
authors.forename: S
authors.initials: S
authors.lastname: Blond
authors.forename: J L
authors.initials: JL
authors.lastname: Bourriez
authors.forename: J D
authors.initials: JD
authors.lastname: Gieu
authors.forename: A
authors.initials: A
authors.lastname: Destée
mesh_terms: D000843:Ankle Joint; D004558:Electric Stimulation; D005260:Female; D007839:Functional Laterality; D005684:Gait; D006621:Hip Joint; D006801:Humans; D007719:Knee Joint; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology* / Q000601:surgery; D010388:Pelvis; D011187:Posture; D013787:Thalamic Nuclei / Q000503:physiopathology*; D013788:Thalamus / Q000601:surgery; D016138:Walking