title: A solution-phase strategy for the synthesis of chemical libraries containing small organic molecules: a universal and dipeptide mimetic template.
abstract: A general approach to the solution phase, parallel synthesis of chemical libraries, which allows the preparation of multi-milligram quantities of each individual member, is exemplified with both a universal and dipeptide mimetic template. In each step of the sequence, the reactants, unreacted starting material, reagents and their byproducts are removed by simple liquid/ liquid or liquid/solid extractions providing the desired intermediates and final compounds in high purities (> or = 90-100%) independent of the reaction yields and without deliberate reaction optimization.
authors.affiliation: CombiChem, Inc., San Diego, CA 92121, USA.
authors.forename: S
authors.initials: S
authors.lastname: Cheng
authors.forename: C M
authors.initials: CM
authors.lastname: Tarby
authors.forename: D D
authors.initials: DD
authors.lastname: Comer
authors.forename: J P
authors.initials: JP
authors.lastname: Williams
authors.forename: L H
authors.initials: LH
authors.lastname: Caporale
authors.forename: P L
authors.initials: PL
authors.lastname: Myers
authors.forename: D L
authors.initials: DL
authors.lastname: Boger
mesh_terms: D004151:Dipeptides / Q000138:chemical synthesis* / Q000592:standards*; D015195:Drug Design; D012996:Solutions / Q000737:chemistry; D013698:Templates, Genetic
chemical_list: D004151:Dipeptides; D012996:Solutions