title: Influence of different fasting periods on P-31-MR-spectroscopy of the liver in normals and patients with liver metastases.
abstract: The purpose of this study was to determine the influence of different fasting periods on the in vivo P-31-MR spectroscopy of the healthy liver and patients with liver metastases. Image-guided localized P-31-MRS was performed in 24 patients with liver metastases and in 20 healthy volunteers. The spectra were obtained with a whole body scanner operating at 1.5 T using a surface coil. The P-31-MRS was performed after a fasting period of 3-5 h (group 1) and after overnight fasting (group 2). The PME/beta-NTP, PDE/beta-NTP and Pi/beta-NTP were calculated from P-31-MR spectra and were compared in relation to the nutrition status of the volunteers and patients. The PME/beta-NTP and PDE/beta-NTP were significantly increased in spectra of patients with metastases. There were no significant changes in the ratios of phosphorus metabolites in healthy liver tissue or in liver metastases after a fasting period of 3-5 h as compared with overnight fasting.
authors.affiliation: Department of Diagnostic Radiology, Christian-Albrechts-University of Kiel, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Brinkmann
authors.forename: U H
authors.initials: UH
authors.lastname: Melchert
authors.forename: C
authors.initials: C
authors.lastname: Muhle
authors.forename: J
authors.initials: J
authors.lastname: Brossmann
authors.forename: J
authors.initials: J
authors.lastname: Link
authors.forename: M
authors.initials: M
authors.lastname: Reuter
authors.forename: M
authors.initials: M
authors.lastname: Heller
mesh_terms: D000328:Adult; D000368:Aged; D005215:Fasting; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008113:Liver Neoplasms / Q000378:metabolism* / Q000556:secondary*; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods; D008297:Male; D008875:Middle Aged; D009711:Nucleotides / Q000378:metabolism; D010755:Organophosphates / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism*; D010759:Phosphorus Isotopes
chemical_list: D009711:Nucleotides; D010755:Organophosphates; D010710:Phosphates; D010759:Phosphorus Isotopes; D010758:Phosphorus