title: The effect of reduced physical activity on longevity of mice.
abstract: Reduced physical activity leads, in female mice, to a reduction of the average and maximal life span. The average age at death of the inactive experimental group was 497 +/- 121 days (mean +/- S.D.) compared to 557 +/- 139 days in the active control group, and the six oldest inactive experimental mice died at age 732 +/- 50 days, while the six oldest active control mice died at 890 +/- 52 days. The restriction of mobility was connected with a higher growth rate and a higher body weight in spite of a significant decrease in food intake. In spite of a reduced food intake leading to a reduced whole body metabolism, the results show that mobility restriction shortens life span in female mice.
authors.affiliation: Institute of Medical Chemistry and Pregl Laboratory, Karl-Franzens-Universität Graz, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Mlekusch
authors.forename: H
authors.initials: H
authors.lastname: Tillian
authors.forename: M
authors.initials: M
authors.lastname: Lamprecht
authors.forename: H
authors.initials: H
authors.lastname: Trutnovsky
authors.forename: R
authors.initials: R
authors.lastname: Horejsi
authors.forename: G
authors.initials: G
authors.lastname: Reibnegger
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight / Q000502:physiology*; D004435:Eating / Q000502:physiology*; D005260:Female; D008136:Longevity / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000502:physiology*; D012149:Restraint, Physical