Cell adhesion molecules in HTLV-I infection.
Cell adhesion molecules expressed on the cell surface of leukemic cells and on vascular endothelial cells may play a key role in trafficking, localization, and infiltration of leukemic cells in adult T-cell leukemia (ATL). The predominant adhesion pathway between ATL cells or human T-cell leukemia virus type I (HTLV-I)-infected cell lines and human umbilical vein endothelial cells (HUVECs) is an E-selectin-mediated pathway as determined by studies using adhesion-blocking monoclonal antibodies, although fresh leukemic cells and HTLV-I-infected cell lines also expressed LFA-I, VLA-4, L-selectin, and CD44. Our study also strongly suggested the presence of adhesion pathway(s) mediated by as yet unknown cell adhesion molecule(s), to which we have recently developed monoclonal antibodies.
Uchiyama
T
T
Research Center for Immunodeficiency Virus, Kyoto University, Japan.
Ishikawa
T
T
Imura
A
A
D002448:Cell Adhesion / Q000276:immunology / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000096:biosynthesis* / Q000502:physiology*; D002461:Cell Line, Transformed; D002465:Cell Movement / Q000276:immunology / Q000502:physiology; D004727:Endothelium / Q000166:cytology / Q000378:metabolism*; D015490:HTLV-I Infections / Q000276:immunology*; D006801:Humans; D013601:T-Lymphocytes / Q000378:metabolism* / Q000821:virology; D014407:Tumor Cells, Cultured; D014471:Umbilical Veins / Q000166:cytology / Q000378:metabolism*
D015815:Cell Adhesion Molecules