Interleukin-1 and its inhibitors: implications for disease biology and therapy.
IL-1 alpha and IL-1 beta are polypeptide hormones that exhibit a broad spectrum of beneficial and harmful biologic activities. Clinical trials designed to benefit from its stimulatory effects on human hematopoiesis and from its role in improving host defenses, are being currently conducted. Other in vivo studies, using IL-1 inhibitors with an attempts to block the detrimental effects of IL-1, are underway. Because of the multifunctional effects of IL-1 in human physiology and its pathogenetic role in several diseases, the capability to control the effects of IL-1 may prove to be a useful tool in medical practice.
Estrov
Z
Z
Department of Bioimmunotherapy, UT MD Anderson Cancer Center, Houston, Texas 77030, USA.
Kurzrock
R
R
Talpaz
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001855:Bone Marrow Diseases / Q000628:therapy; D020170:Caspase 1; D003546:Cysteine Endopeptidases / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D007249:Inflammation / Q000503:physiopathology; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000009:adverse effects / Q000037:antagonists & inhibitors / Q000235:genetics / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D009369:Neoplasms / Q000628:therapy; D011499:Protein Processing, Post-Translational; D017472:Receptors, Interleukin-1 / Q000187:drug effects / Q000502:physiology; D012772:Shock, Septic / Q000628:therapy; D012795:Sialoglycoproteins / Q000502:physiology / Q000627:therapeutic use; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D013498:Suramin / Q000494:pharmacology / Q000627:therapeutic use
D000970:Antineoplastic Agents; C507763:IL1RN protein, human; D007155:Immunologic Factors; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins; D013498:Suramin; D003546:Cysteine Endopeptidases; D020170:Caspase 1