Transmembrane Ca2+ gradient and function of membrane proteins.
This review will focus on the recent advance in the study of effect of transmembrane Ca2+ gradient on the function of membrane proteins. It consits of two parts: 1. Transmembrane Ca2+ gradient and sarcoplasmic reticulum Ca(2+)-ATPase; 2. Effect of transmembrane Ca2+ gradient on the components and coupling of cAMP signal transduction pathway. The results obtained indicate that a proper transmembrane Ca2+ gradient may play an important role in modulating the conformation and activity of SR Ca(2+)-ATPase and the function of membrane proteins involved in the cAMP signal transduction by mediating the physical state change of the membrane phospholipids.
Yang
F Y
FY
National Laboratory of Biomacromolecules, Institute of Biophysics, Beijing, China.
Huang
Y G
YG
Tu
Y P
YP
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D006801:Humans; D017136:Ion Transport; D008565:Membrane Proteins / Q000378:metabolism*; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*; D015398:Signal Transduction
D008565:Membrane Proteins; D000252:Calcium-Transporting ATPases; D002118:Calcium