All-trans retinoic acid affects the expression of orphan receptors COUP-TF I and COUP-TF II in the developing neural tube.
The effect of all-trans retinoic acid (RA) on chicken ovalbumin upstream promoter-transcription factor (COUP-TF) I and COUP-TF II expression in the developing cervical spinal cord and telencephalon was examined using embryonic day 11 and 13 mice. All-trans RA treatment results in changes in expression of COUP-TF I and COUP-TF II genes in the spinal cord and telencephalon. COUP-TF I mRNA levels were reduced in the spinal cord ventricular zone (VZ) after treatment, whereas in the telencephalon, mRNA levels were unaffected in the VZ and increased in the intermediate zone (IZ). COUP-TF II mRNA levels were increased in the spinal cord VZ after treatment, while in the telencephalon, IZ mRNA levels were decreased in the E11 embryos and increased in E13 embryos.
Brubaker
K
K
Department of Anatomy and Neurobiology, Colorado State University, Fort Collins 80523, USA.
McMillan
M
M
Neuman
T
T
Nornes
H O
HO
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D051838:COUP Transcription Factor I; D051836:COUP Transcription Factors; D002490:Central Nervous System / Q000737:chemistry / Q000196:embryology*; D004268:DNA-Binding Proteins / Q000187:drug effects* / Q000235:genetics; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects; D017403:In Situ Hybridization; D051379:Mice; D008813:Mice, Inbred ICR; D008969:Molecular Sequence Data; D011247:Pregnancy; D012333:RNA, Messenger / Q000032:analysis; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000235:genetics; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000235:genetics; D011987:Receptors, Steroid; D014157:Transcription Factors / Q000187:drug effects* / Q000235:genetics; D014212:Tretinoin / Q000494:pharmacology*
D000970:Antineoplastic Agents; D051838:COUP Transcription Factor I; D051836:COUP Transcription Factors; D004268:DNA-Binding Proteins; C497590:Nr2f1 protein, mouse; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D014157:Transcription Factors; D014212:Tretinoin