Radiation biology of lung cancer.
The enormous problem that is lung cancer still defies satisfactory therapeutic strategy. This article summarizes some of the more important laboratory efforts directed at understanding the biology of this complex disease. The radiation sensitivities of established lung cancer cell lines are outlined. The effect of radiation dose rate and chemotherapy is explored. The emerging biology of oncogenetic alterations is explored as it relates to radiation sensitivity in general, and lung cancer in particular. Finally, novel therapeutic approaches including photodynamic therapy are introduced.
Sullivan
F J
FJ
Radiation Oncology Branch, NCI, Bethesda, Maryland 20992, USA.
Carmichael
J
J
Glatstein
E
E
Mitchell
J B
JB
D000970:Antineoplastic Agents / Q000494:pharmacology; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D004307:Dose-Response Relationship, Radiation; D019008:Drug Resistance, Neoplasm; D006367:HeLa Cells / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*; D009857:Oncogenes / Q000528:radiation effects; D010778:Photochemotherapy; D011836:Radiation Tolerance; D014407:Tumor Cells, Cultured / Q000528:radiation effects; D014410:Tumor Stem Cell Assay
D000970:Antineoplastic Agents