Genetics of insulin-dependent diabetes; non-major histocompatibility genes.
Recently, the major advances in understanding the genetics of type 1 diabetes have come using the positional cloning approach, both in mouse and human. Construction of congenic mouse strains and, in human, the exploitation of linkage disequilibrium between very closely linked markers and disease-predisposing loci, is enabling fine mapping of these loci.
Merriman
T R
TR
University of Oxford, United Kingdom.
Todd
J A
JA
D000818:Animals; D002874:Chromosome Mapping; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D008040:Genetic Linkage; D006239:Haplotypes; D006801:Humans; D051379:Mice; D016688:Mice, Inbred NOD