title: The activity of azithromycin on the infectivity of Chlamydia trachomatis in human amniotic cells.
abstract: The effects of azithromycin on the infectivity and growth of Chlamydia trachomatis were investigated in primary human amniotic epithelial cells. Infection was prevented when cultures were exposed to the drug 6 h after inoculation and growth was completely inhibited when the drug was added to cultures 24, 48, 72 h or 7 days after infection. The same inhibition was observed at 0.5, 1.0 and 5.0 mg/L. Ultrastructural observations depicted interruption in the growth cycle of the chlamydia and ghost-like envelopes were present in the near empty inclusions. Azithromycin is effective in inhibiting chlamydial growth no matter when treatment is initiated after infection.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Washington, Seattle 98195, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Patton
authors.forename: S K
authors.initials: SK
authors.lastname: Wang
authors.forename: C C
authors.initials: CC
authors.lastname: Kuo
mesh_terms: D000650:Amnion / Q000166:cytology / Q000187:drug effects / Q000382:microbiology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001345:Autoradiography; D017963:Azithromycin / Q000494:pharmacology*; D002250:Carbon Radioisotopes; D002692:Chlamydia trachomatis / Q000187:drug effects* / Q000472:pathogenicity* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D011247:Pregnancy
chemical_list: D000900:Anti-Bacterial Agents; D002250:Carbon Radioisotopes; D017963:Azithromycin