Immunomodulatory activities of Cedrela tubiflora leaf aqueous extracts.
Human peripheral blood monocytes and polymorphonuclear leukocytes treated with leaf aqueous extracts of the Meliaceae tree Cedrela tubiflora showed a diminution in both their phagocytic and respiratory burst activities. Besides, the extract inhibited the proliferation of Concanavalin A stimulated lymphocytes. A decrease in the hemolytic capacity of the human complement was also observed. The significance of the inhibitory effect observed over some components of the human immune system closely related with the inflammatory process is discussed.
Benencia
F
F
Laboratory of Virology, University of Buenos Aires, Argentina.
Courrèges
M C
MC
Nores
M M
MM
Coulombié
F C
FC
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D001118:Argentina; D002455:Cell Division / Q000187:drug effects; D003167:Complement Activation / Q000187:drug effects*; D003208:Concanavalin A / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007962:Leukocytes / Q000166:cytology / Q000187:drug effects*; D008934:Mitogens / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D037121:Plant Lectins; D010946:Plants, Medicinal; D016897:Respiratory Burst / Q000187:drug effects
D000276:Adjuvants, Immunologic; D008934:Mitogens; D010936:Plant Extracts; D037121:Plant Lectins; D003208:Concanavalin A