Absence of CD69 expression on peripheral eosinophils in episodic angioedema and eosinophilia.
A 45-year-old woman with episodic angioedema and eosinophilia is presented. CD69, which is one of the surface antigens of activated eosinophils, was not expressed on the peripheral eosinophils in this patient, in contrast to hypereosinophilic syndrome. This suggests that CD69, which is not dependent on eosinophil density, may be another useful activation marker of eosinophils to distinguish episodic angioedema and eosinophilia from hypereosinophilic syndrome.
Kawano
M
M
Second Department of Internal Medicine, Kanazawa University, Japan.
Muramoto
H
H
Tsunoda
S
S
Koni
I
I
Mabuchi
H
H
Yachie
A
A
Miyawaki
T
T
D000799:Angioedema / Q000276:immunology*; D015703:Antigens, CD / Q000096:biosynthesis*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000096:biosynthesis*; D004802:Eosinophilia / Q000276:immunology*; D004804:Eosinophils / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique; D005786:Gene Expression Regulation; D006801:Humans; D037181:Lectins, C-Type; D008875:Middle Aged; D000099192:CD69 Antigens
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D037181:Lectins, C-Type; D000099192:CD69 Antigens