Effects of TRH and atropine on induction and duration of anesthesia with propofol in rats.
The effects of IV TRH pretreatment on induction of anesthesia with propofol or pentobarbital were investigated in rats. The effects of IV TRH, administered after induction, on duration of propofol anesthesia and the interaction with atropine were also studied. The doses of propofol or pentobarbital were not influenced by TRH. TRH reduced duration of anesthesia after propofol, with higher brain concentrations of propofol at recovery. Atropine did not block this effect, but given alone prolonged duration of anesthesia. It is concluded that TRH shortens the duration of propofol anesthesia, probably due to a pharmacodynamic effect and not to a pharmacokinetic interaction.
Larsson
J E
JE
Department of Pharmacology, Umeå University, Sweden.
Koskinen
L O
LO
Wahlström
G
G
D000758:Anesthesia; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D010424:Pentobarbital / Q000008:administration & dosage / Q000494:pharmacology; D010863:Piloerection / Q000187:drug effects; D015742:Propofol; D051381:Rats; D017207:Rats, Sprague-Dawley; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D014202:Tremor
D013973:Thyrotropin-Releasing Hormone; D001285:Atropine; D010424:Pentobarbital; D015742:Propofol