Contraceptive treatment increases the affinity of uterine estrogen receptor in adult rat: perinatal gestagen treatment changes the reaction.
Uterus estrogen receptor affinity increases in adult rats if treated with contraceptive, without receptor density change. Uterus estrogen receptor density decreases in adulthood following allylestrenol (Gestanon) treatment perinatally with receptor affinity unchanging. In perinatally allylestrenol treated rats contraceptive treatment resulted in the decrease of receptor affinity and increase of density, related to the only perinatally allylestrenol treated animals. The results draw attention to the fact that contraceptives may influence the estrogen receptor state of the uterus and the pregnancy maintaining treatment (by allylestrenol) may influence the state of uterine estrogen receptors for life via the later effect of contraceptives commonly dosed.
Csaba
G
G
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
Gonda
A I
AI
Karabélyos
C
C
D000500:Allylestrenol / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D045166:Estradiol Congeners / Q000494:pharmacology; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D007700:Kinetics; D009092:Mucous Membrane / Q000187:drug effects / Q000378:metabolism; D009644:Norgestrel / Q000494:pharmacology; D045167:Progesterone Congeners / Q000494:pharmacology; D051381:Rats; D011960:Receptors, Estrogen / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
D003278:Contraceptives, Oral, Hormonal; D045166:Estradiol Congeners; D045167:Progesterone Congeners; D011960:Receptors, Estrogen; D009644:Norgestrel; D004997:Ethinyl Estradiol; D000500:Allylestrenol