Chiral resolution of the dansyl derivative of 2-methyltaurine by capillary electrophoresis.
A cyclodextrin-modified micellar capillary electrophoretic method was developed for the chiral separation of 2-methyltaurine. The racemic mixture was separated after derivatization with dansyl chloride. The enantiomeric separation of the dansyl derivative was done using electrolyte solutions containing beta-cyclodextrin (beta-CD) or different ratios of beta- and gamma-CD. The mixture of beta- and gamma-CD optimally resolved the compound studied.
Anselmi
S
S
Dipartimento di Scienze Farmaceutiche, Università di Modena, Italy.
Braghiroli
D
D
Di Bella
M
M
Schmid
M G
MG
Wintersteiger
R
R
Gübitz
G
G
D003505:Cyclodextrins / Q000737:chemistry*; D003619:Dansyl Compounds / Q000737:chemistry*; D004573:Electrolytes / Q000737:chemistry; D019075:Electrophoresis, Capillary / Q000379:methods*; D008823:Micelles; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D013237:Stereoisomerism; D013654:Taurine / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification*
D003505:Cyclodextrins; D003619:Dansyl Compounds; D004573:Electrolytes; D008823:Micelles; D013654:Taurine; D012967:Sodium Dodecyl Sulfate; C103438:2-methyltaurine; C029038:dansyl chloride