title: Bile salt inhibits acid-promoting feeding tube occlusion.
abstract: Occlusion of feeding tubes is a common and costly complication of enteral feeding. Although the composition of feeding formulas, the size, design, and material of the feeding tube, and the rate of delivery have been considered as factors that determine the rate of tube occlusion, little information is available on the effect of the luminal content of the gut on tube occlusion. Enteral feeding tubes are placed either in the stomach or postpylorically, in the small intestine. The chemical composition of these regions including acidity and bile salt concentration may vary. Since acidity has been shown to promote tube occlusion and bile salts have detergent-like properties, these chemical differences in the luminal environment may be important to tube occlusion. To test the idea that bile salt inhibits acid-promoted occlusion of feeding tubes, in an in vitro study, we compared the time-to-complete occlusion of four groups of formula-filled feeding tubes (six tubes in each group) immersed in an acidic solution (pH 3.0) containing 0 (control), 10, 20, or 40 mM of taurocholate. We found that although 33% of the feeding tubes were occluded within 12 hours in the absence of exposure to bile salt, none were occluded when 20 or 40 mM of taurocholate was added to the acidic solution. After 24 hours, 40 mM of taurocholate inhibited acid-promoted occlusion of 67% of the feeding tubes. Thus 0 to 40 mM of taurocholate still inhibited acid-promoted tube occlusion in a dose-dependent fashion (p < .05). Acidity and the concentration of bile salt may work together, but in opposite directions, as luminal factors that determine the rate of occlusion of feeding tubes.
authors.forename: D
authors.initials: D
authors.lastname: Yeoh
authors.forename: X T
authors.initials: XT
authors.lastname: Zhao
authors.forename: S L
authors.initials: SL
authors.lastname: Sanders
authors.forename: J D
authors.initials: JD
authors.lastname: Elashoff
authors.forename: G
authors.initials: G
authors.lastname: Bonorris
authors.forename: H C
authors.initials: HC
authors.lastname: Lin
mesh_terms: D002756:Cholagogues and Choleretics; D004353:Drug Evaluation, Preclinical; D004750:Enteral Nutrition / Q000295:instrumentation*; D004868:Equipment Failure; D005745:Gastric Acidity Determination; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007441:Intubation, Gastrointestinal / Q000295:instrumentation*; D013656:Taurocholic Acid
chemical_list: D002756:Cholagogues and Choleretics; D013656:Taurocholic Acid