Achieving natural product synthesis and diversity via catalytic networking ex vivo.
Recent studies on ex vivo synthesis of natural products reveal that even complex multistep pathways can be successfully reconstructed. Genetic engineering of such reconstituted pathways has already been used to generate 'unnatural' natural products related to the original compound. In the future, it may be possible to use these approaches to make natural products that are currently inaccessible to conventional synthesis.
Roessner
C A
CA
Center for Biological NMR, Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA.
Scott
A I
AI
D002241:Carbohydrates / Q000096:biosynthesis; D002384:Catalysis; D045728:Corrinoids; D004798:Enzymes / Q000378:metabolism*; D011166:Porphyrins / Q000096:biosynthesis
D002241:Carbohydrates; D045728:Corrinoids; D004798:Enzymes; D011166:Porphyrins