Synthesis and inhibitory activity of glycosidase inhibitors, glycosylamino-oxazolines.
In connection with structural modification of the trehalase inhibitor trehazolin (1), as a new-type of glycohydrolase inhibitor, some glycosylamino-oxazolines were designed and synthesized. Among three oxazolines beta-galacto (3), beta-gluco (5) and alpha-manno-types (6) obtained in stable form, the latter 6 has been shown to possess a moderate inhibitory activity against alpha-mannosidase.
Uchida
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Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
Ogawa
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D000818:Animals; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D004926:Escherichia coli / Q000201:enzymology; D007887:Fabaceae / Q000201:enzymology; D005959:Glucosidases / Q000037:antagonists & inhibitors*; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007928:Lethal Dose 50; D008099:Liver / Q000201:enzymology; D009754:Nuts / Q000201:enzymology; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D010946:Plants, Medicinal; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D006027:Glycosides; D010080:Oxazoles; D005959:Glucosidases