Transdermal drug delivery: useful paradigms.
The successful development of transdermal delivery systems requires a systematic evaluation and understanding of a number of complex phenomena. For example, the study of drug transport through skin (and other biomembranes) has lead to a significant advance in our ability to select drugs which are appropriate for transdermal delivery. Drug release from the transdermal system is also crucial to effective drug delivery and provides a clear opportunity for research in adhesion, polymer physical chemistry, mass transport, and film coating, to name a few. The incorporation of several disciplines into transdermal science holds the exciting promise to provide rapid advances in this technology.
Potts
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Cygnus Therapeutic Systems, Redwood City, CA 94063, USA.
Cleary
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D000279:Administration, Cutaneous; D000818:Animals; D002626:Chemistry, Pharmaceutical; D006801:Humans; D012867:Skin / Q000737:chemistry / Q000378:metabolism*; D012879:Skin Physiological Phenomena