Effect of ethanol on amino acids and related compounds in rat plasma, heart, aorta, bronchus, and pancreas.
The composition of 36 amino acids and related amino compounds is presented for plasma, aorta, heart, pancreas, and bronchi. The distribution pattern of these biochemicals is similar but not identical among the tissues. The effect of an acute dose of ethanol (2 g/kg, i.p.) on these amino acids and related compounds was then studied. In the plasma, alanine, arginine, aspartic acid, beta-alanine, glycine, phenylalanine, and serine are decreased. In the aorta, ammonia and taurine are decreased. In the heart, aspartic acid and leucine are decreased, and carnosine, GABA, glutamic acid, and ornithine are increased. In the pancreas, asparagine and taurine are decreased, and citrulline, cysteine, histidine, and isoleucine are increased. In the bronchi, GABA, ethanolamine, histidine, taurine, and isoleucine are decreased. A number of correlations of some compounds in plasma or tissues were found but differed often between control and ethanol-treated animals. Ethanol-induced tissue changes generally do not correlate with plasma changes and are mostly specific for a given tissue.
Abdel-Nabi
R
R
Department of Pharmacology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Milakofsky
L
L
Hofford
J M
JM
Hare
T A
TA
Vogel
W H
WH
D000596:Amino Acids / Q000097:blood / Q000378:metabolism*; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism; D001980:Bronchi / Q000187:drug effects / Q000378:metabolism; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D000596:Amino Acids; D002492:Central Nervous System Depressants; D000431:Ethanol