[Clinical significance of the determination of protein C dependent disorders of hemostasis in surgical patients].
Diagnostic value of protein C measurements was investigated in 159 surgical patients with diseases of the liver, great vessels, and wound infection. Protein C antigen was detected by ELISA with specific antibodies to protein C. The changes of protein C antigenic activity correlated with severity of hepatic disorders. Inhibition of protein C synthetic activity went on in parallel with a fall in pseudocholine esterase concentrations. This suggests feasibility of protein C measurements for examination of protein production by the liver. Characteristics and location of the lesions in great vessels were also related to protein C antigen levels. The fall in this antigen quantity was observed in patients with purulent wound infection. The greater the fall, the more serious the patient's condition became.
Karelin
A A
AA
Adamian
A A
AA
Titova
M I
MI
Egorova
V V
VV
D001778:Blood Coagulation Disorders / Q000175:diagnosis / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000601:surgery; D008107:Liver Diseases / Q000175:diagnosis / Q000601:surgery; D011379:Prognosis; D011486:Protein C / Q000032:analysis* / Q000276:immunology; D013514:Surgical Procedures, Operative; D013530:Surgical Wound Infection / Q000175:diagnosis; D014652:Vascular Diseases / Q000175:diagnosis / Q000601:surgery
D011486:Protein C