Removal of autoantibodies in dilated cardiomyopathy by immunoadsorption.
Immunoadsorption with Ig-Therasorb leads to a marked decrease in serum levels of immunoglobulins including of the agonist-like anti-beta 1-adrenoceptor autoantibody found in the serum of patients with idiopathic dilated cardiomyopathy. The reduction in autoantibody levels was accompanied by an improvement of heart function and a shift to a lower NYHA state. In this disease, as in a variety of other autoimmune disorders, apheresis with Ig-Therasorb led to a rapid improvement of the clinical status and could be used in end-stage dilated cardiomyopathy (with autoantibodies) as a bridge for transplantation.
Wallukat
G
G
Max Delbrück Centre for Molecular Medicine, Berlin, Germany.
Reinke
P
P
Dörffel
W V
WV
Luther
H P
HP
Bestvater
K
K
Felix
S B
SB
Baumann
G
G
D001323:Autoantibodies; D009202:Cardiomyopathies / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007163:Immunosorbent Techniques; D016896:Treatment Outcome
D001323:Autoantibodies