Cholesterol-fed rabbits: study of the response of the vas deferens to adrenergic and non-adrenergic stimulus and to a kappa-opioid agonist.
The aim of the present study was to analyse the contractility of the isolated vas deferens from hypercholesterolaemic rabbits; for this purpose we evaluated the contractile response induced by noradrenaline and by electrical stimulation. A significant increase in the amplitude of adrenergic and non-adrenergic responses was observed in vas deferens from hypercholesterolaemic rabbits. These data suggest an increase in the contractility of the smooth muscle in these animals.
Alfaro
M J
MJ
Departamento de Farmacología, Facultad de Medicina, Universidad Complutense de Madrid, Spain.
Ormazábal
M J
MJ
García-Arroba
L
L
Martín
M I
MI
D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D000322:Adrenergic Agonists / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D002791:Cholesterol, Dietary / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D006937:Hypercholesterolemia / Q000503:physiopathology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology; D011817:Rabbits; D017473:Receptors, Opioid, kappa / Q000819:agonists*; D014649:Vas Deferens / Q000187:drug effects / Q000502:physiology*
D000322:Adrenergic Agonists; D000959:Antihypertensive Agents; D002791:Cholesterol, Dietary; D011759:Pyrrolidines; D017473:Receptors, Opioid, kappa; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D009638:Norepinephrine