Familial type V hyperlipoproteinemia with hyper-remnant-like particle-cholesterol accompanied with apolipoprotein E3/E4 phenotype.
A 41-year-old woman and her 2 sons had Type V hyperlipoproteinemia. Interestingly, the patient and her younger son had higher levels of remnant-like particle (RLP)-cholesterol than her elder son; the former two had apolipoprotein E phenotype E3/E4, while the latter had E3/E3. Hyper-RLP-ch levels may be associated with the apolipoprotein E4 phenotype. Moreover, after administration of bezafibrate, the patient's triglyceride, RLP-cholesterol and RLP-triglyceride levels decreased markedly and the chylomicron fraction disappeared. Further studies may be necessary to determine if hypertriglyceridemic patients with or without apolipoprotein E4 show a greater reduction in serum TG levels with lipid-lowering agents.
Nagai
T
T
Department of Internal Medicine, Public Tomioka General Hospital.
Tomizawa
T
T
Saito
T
T
Nakano
T
T
Nakajima
K
K
Mori
M
M
D000328:Adult; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics*; D001629:Bezafibrate / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood* / Q000737:chemistry; D002914:Chylomicrons / Q000097:blood*; D005260:Female; D006493:Heparin; D006801:Humans; D006954:Hyperlipoproteinemia Type V / Q000097:blood* / Q000188:drug therapy / Q000235:genetics; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D008049:Lipase / Q000097:blood; D008071:Lipoprotein Lipase / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood*; D008297:Male; D010641:Phenotype; D014280:Triglycerides / Q000097:blood
D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D002914:Chylomicrons; D000960:Hypolipidemic Agents; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D006493:Heparin; D002784:Cholesterol; D008049:Lipase; D008071:Lipoprotein Lipase; D001629:Bezafibrate