Cardiotoxic properties of cocaine: studies with positron emission tomography.
This study documented marked accumulation of cocaine in the human and baboon heart, which was not inhibited by desipramine pretreatment. However, cocaine inhibited 6-[18F]fluoronorepinephrine uptake in heart to the same degree as did desipramine (Fowler et al. 1994). Since uptake of [18F]norepinephrine in the heart is a function of its uptake by the NE transporter (Fowler et al. 1994), its inhibition by cocaine corroborates in vivo a significant interaction of cocaine with this transporter.
Volkow
N D
ND
Clinical Research Center, Brookhaven National Laboratory, NY, USA.
Fowler
J S
JS
Ding
Y S
YS
D000328:Adult; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D003042:Cocaine / Q000493:pharmacokinetics / Q000633:toxicity*; D006321:Heart / Q000187:drug effects; D006331:Heart Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D009294:Narcotics / Q000493:pharmacokinetics / Q000633:toxicity*; D009638:Norepinephrine / Q000378:metabolism; D050484:Norepinephrine Plasma Membrane Transport Proteins; D010215:Papio; D027981:Symporters; D014055:Tomography, Emission-Computed
D002352:Carrier Proteins; D009294:Narcotics; D050484:Norepinephrine Plasma Membrane Transport Proteins; C493227:SLC6A2 protein, human; D027981:Symporters; D003042:Cocaine; D009638:Norepinephrine