title: Global tests for analysis of multiple tumour data from animal carcinogenicity experiments.
abstract: This paper presents test procedures for testing of the overall dose effect at every tumour type site simultaneously in a chronic animal carcinogenicity bioassay. I derive global tests of the tumour prevalence rates and the tumour onset rates using the generalized estimating equations approach. The test is based on the model of a common dose effect alternative. I used the logistic regression model for simultaneous testing of non-lethal tumours, and the Poly-3 test for testing of mixtures of lethal or non-lethal tumours of different types/sites. An application illustrating the proposed tests concerns analysis of a carcinogenicity experiment designed to study the dose response of hepatocellular and bladder tumours to 2-acetylaminofluorene (2-AAF) exposure.
authors.affiliation: Division of Biometry and Risk Assessment, Food and Drug Administration, Jefferson, Arkansas 72079, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Chen
mesh_terms: D015073:2-Acetylaminofluorene; D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D001681:Biological Assay; D015197:Carcinogenicity Tests; D002273:Carcinogens; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced; D016009:Chi-Square Distribution; D003627:Data Interpretation, Statistical; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D008113:Liver Neoplasms / Q000139:chemically induced; D016015:Logistic Models; D008297:Male; D015233:Models, Statistical; D009378:Neoplasms, Multiple Primary / Q000139:chemically induced; D010212:Papilloma / Q000139:chemically induced; D015995:Prevalence; D012044:Regression Analysis; D016019:Survival Analysis; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced
chemical_list: D002273:Carcinogens; D015073:2-Acetylaminofluorene