title: Removal of autoantibodies in dilated cardiomyopathy by immunoadsorption.
abstract: Immunoadsorption with Ig-Therasorb leads to a marked decrease in serum levels of immunoglobulins including of the agonist-like anti-beta 1-adrenoceptor autoantibody found in the serum of patients with idiopathic dilated cardiomyopathy. The reduction in autoantibody levels was accompanied by an improvement of heart function and a shift to a lower NYHA state. In this disease, as in a variety of other autoimmune disorders, apheresis with Ig-Therasorb led to a rapid improvement of the clinical status and could be used in end-stage dilated cardiomyopathy (with autoantibodies) as a bridge for transplantation.
authors.affiliation: Max Delbrück Centre for Molecular Medicine, Berlin, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Wallukat
authors.forename: P
authors.initials: P
authors.lastname: Reinke
authors.forename: W V
authors.initials: WV
authors.lastname: Dörffel
authors.forename: H P
authors.initials: HP
authors.lastname: Luther
authors.forename: K
authors.initials: K
authors.lastname: Bestvater
authors.forename: S B
authors.initials: SB
authors.lastname: Felix
authors.forename: G
authors.initials: G
authors.lastname: Baumann
mesh_terms: D001323:Autoantibodies; D009202:Cardiomyopathies / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007163:Immunosorbent Techniques; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies