title: Clinical and immunohistochemical characterization of thymic lymphosarcoma in a heifer.
abstract: A 2-year-old Holstein heifer with a swollen brisket, jugular vein distention, muffled heart sounds, tachycardia, and free gas bloat was examined. Thymic lymphosarcoma was suspected based on a negative agar gel immunodiffusion test for bovine leukemia virus, presence of atypical lymphocytes in pleural fluid, and detection of a mass in the thoracic inlet. Right-sided cardiac catheterization was performed, and markedly increased jugular venous pressures (41 mm Hg) with a pressure gradient of 29 mm Hg immediately cranial to the heart indicated constriction of the cranial vena cava. Immunohistochemical staining of formalin fixed, paraffin-embedded tissue sections of the tumor using a rabbit antihuman T cell, CD3 polyclonal antibody confirmed that the neoplastic lymphocytes were of thymic origin.
authors.affiliation: Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign 61801, USA.
authors.forename: A N
authors.initials: AN
authors.lastname: Alexander
authors.forename: P D
authors.initials: PD
authors.lastname: Constable
authors.forename: W A
authors.initials: WA
authors.lastname: Meier
authors.forename: R A
authors.initials: RA
authors.lastname: French
authors.forename: D E
authors.initials: DE
authors.lastname: Morin
authors.forename: J E
authors.initials: JE
authors.lastname: Lowry
authors.forename: W E
authors.initials: WE
authors.lastname: Hoffman
mesh_terms: D000818:Animals; D000906:Antibodies; D001707:Biopsy, Needle; D017252:CD3 Complex / Q000276:immunology; D002417:Cattle; D002418:Cattle Diseases; D004562:Electrocardiography / Q000662:veterinary; D005260:Female; D006801:Humans; D007601:Jugular Veins / Q000000981:diagnostic imaging; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary / Q000662:veterinary; D008207:Lymphatic Metastasis; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D011817:Rabbits; D013601:T-Lymphocytes / Q000276:immunology; D013953:Thymus Neoplasms / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D014463:Ultrasonography
chemical_list: D000906:Antibodies; D017252:CD3 Complex