A transcription map of the major histocompatibility complex (MHC) class I region.
We have applied cDNA hybridization selection to nine YACs spanning 3 Mb of genomic DNA from a region centromeric to HLA-A to the histone cluster that lies telomeric to the human major histocompatibility complex (MHC). In addition to Class I genes and pseudogenes, we describe over 63 genes and 23 additional expressed sequence tags distributed throughout the region. Many of the full-length genes belong to gene families. Prominent among these are a group of genes encoding proteins showing homology to the carboxyl-terminal sequences of butyrophilin and an additional group of zinc finger genes. We also detected several previously undefined genes that are specifically expressed in cells of the immune system, indicating a more complex role of the MHC in the immune response than has been appreciated.
Gruen
J R
JR
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, 06520, USA.
Nalabolu
S R
SR
Chu
T W
TW
Bowlus
C
C
Fan
W F
WF
Goei
V L
VL
Wei
H
H
Sivakamasundari
R
R
Liu
Y
Y
Xu
H X
HX
Parimoo
S
S
Nallur
G
G
Ajioka
R
R
Shukla
H
H
Bray-Ward
P
P
Pan
J
J
Weissman
S M
SM
D000595:Amino Acid Sequence; D001483:Base Sequence; D002874:Chromosome Mapping / Q000379:methods*; D018244:Chromosomes, Artificial, Yeast / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics*; D019143:Evolution, Molecular; D015870:Gene Expression; D005805:Genes, MHC Class I / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics; D011544:Pseudogenes / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D014158:Transcription, Genetic; D016335:Zinc Fingers
D018076:DNA, Complementary; D012333:RNA, Messenger