The regulation of retinoic acid formation.
Rat liver microsomal as well as cytosolic retinol dehydrogenases from cellular retinal-binding protein (CRBP)-retinal from CRBP-retinol. A cytosolic dehydrogenase transforms retinal into retinoic acid. Apo-CRBP and ethanol inhibit the cytosolic but not the microsomal retinol dehydrogenase, the latter being the primary enzyme in the rate-limiting step in retinoic acid synthesis.
Wolf
G
G
Department of Nutritional Sciences, University of California at Berkeley 94720-3104, USA.
D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000818:Animals; D000072467:Cytochrome P450 Family 2; D003600:Cytosol / Q000201:enzymology; D008099:Liver / Q000201:enzymology / Q000648:ultrastructure; D008862:Microsomes, Liver / Q000201:enzymology; D051381:Rats; D012172:Retinaldehyde / Q000378:metabolism; D012177:Retinol-Binding Proteins / Q000378:metabolism; D054840:Retinol-Binding Proteins, Cellular; D014212:Tretinoin / Q000378:metabolism*
D012177:Retinol-Binding Proteins; D054840:Retinol-Binding Proteins, Cellular; D014212:Tretinoin; D000429:Alcohol Oxidoreductases; C022520:retinol dehydrogenase; C504568:Cyp2d1 protein, rat; D000072467:Cytochrome P450 Family 2; D012172:Retinaldehyde