Organization of the chicken histone genes in a major gene cluster and generation of an almost complete set of the core histone protein sequences.
We present a detailed picture of the disposition of the histone genes in the chicken genome and an almost complete set of the core histone protein sequences. Thirty-nine histone genes, six H1, nine H2A, eight H2B, eight H3 and eight H4, were located within a histone gene cluster of 110 kb, which was covered by five cosmid clones and two lambda clones. Results of our sequence analyses, together with those reported previously, generated a set of the core histone amino acid sequences as follows: three H2A variants, four H2B variants, two H3 variants and an H4 protein.
Takami
Y
Y
Department of Biochemistry, Miyazaki Medical College, Japan.
Higashio
M
M
Fukuoka
T
T
Takechi
S
S
Nakayama
T
T
D000595:Amino Acid Sequence; D000818:Animals; D002645:Chickens / Q000235:genetics*; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D006657:Histones / Q000737:chemistry* / Q000235:genetics*; D005810:Multigene Family; D016366:Open Reading Frames; D015183:Restriction Mapping; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid
D006657:Histones