Effect of oxybutynin on the QTc interval in elderly patients with urinary incontinence.
1. Terodiline, an anticholinergic drug with calcium antagonist properties, is associated with QT prolongation and ventricular arrhythmias. It is not known if oxybutynin, a drug with a similar pharmacological profile, causes QT prolongation. ECGs were obtained before and at least 4 weeks after commencement of oxybutynin (mean daily dose 7.6, range 2.5-10 mg), in 21 elderly (mean age 75, range 58-88 years) patients treated for urinary incontinence. Heart rate, (mean +/- s.d.) 74 +/- 11 vs 69 +/- 11 beats min-1, -6 (-13,2), before vs during oxybutynin therapy, mean difference (95% confidence intervals); PR interval, 168 +/- 27 vs 156 +/- 27 ms, -11 (-26,3); QTc 454 +/- 27 vs 447 +/- 31 ms1/2, -9 (-23,5), and QTc dispersion, QTc max-QTc min, 68 +/- 24 vs 63 +/- 26 ms1/2, -1 (-15,14) were all unaltered by oxybutynin therapy. The lack of an effect on resting heart rate suggests that oxybutynin has little anticholinergic action at cardiac M2 receptors at usually administered doses. Oxybutynin therapy is not associated with QTc interval prolongation and is unlikely to produce ventricular arrhythmias.
Hussain
R M
RM
Department of Medicine (Geriatrics), University of Newcastle upon Tyne, UK.
Hartigan-Go
K
K
Thomas
S H
SH
Ford
G A
GA
D000368:Aged; D000369:Aged, 80 and over; D004562:Electrocardiography / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008333:Mandelic Acids / Q000494:pharmacology* / Q000627:therapeutic use; D008875:Middle Aged; D010276:Parasympatholytics / Q000494:pharmacology*; D014549:Urinary Incontinence / Q000188:drug therapy*
D008333:Mandelic Acids; D010276:Parasympatholytics; C005419:oxybutynin