Oestrogen receptors and cardiovascular disease.
1. Animal and human studies indicate that female sex hormones are protective against the development of coronary atherosclerosis. 2. Experiments on vascular smooth muscle cells suggest a direct effect of oestrogen on vascular tissue. Although oestrogen receptors (ER) in vascular tissues and an association between ER stimulation and physiological effects have been demonstrated, the cellular mechanisms underlying the effects of oestrogen on the arterial wall remain to be defined. 3. Elucidation of the cellular mechanism underlying the effects of oestrogen on vascular smooth muscle will provide insights into coronary atherosclerosis and will provide an opportunity to apply the protective effects of oestrogen to women in older age groups and to the male population.
Baysal
K
K
Department of Medicine (Cardiology), St. Elizabeth's Hospital, Tufts University School of Medicine, Boston, Massachusetts, USA.
Losordo
D W
DW
D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000503:physiopathology*; D004967:Estrogens / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D011960:Receptors, Estrogen / Q000096:biosynthesis / Q000187:drug effects / Q000502:physiology*
D004967:Estrogens; D011960:Receptors, Estrogen