title: In vitro and in vivo antitrypanosomal activity of Xanthium strumarium leaves.
abstract: Antitrypanosomal activity of crude 50% ethanolic extract of Xanthium strumarium leaves was studied in vitro and in vivo. The extract exhibited trypanocidal activity at all four concentrations tested i.e. 5, 50, 500 and 1000 micrograms/ml, in vitro. In vivo trial revealed that the extract exerted antitrypanosomal effect at dosage of 100, 300 and 1000 mg/kg, intraperitoneally. At 100 and 300 mg/kg doses the survival period of the Trypanosoma evansi infected mice was significantly prolonged. However, the extract was found to be toxic to the animals at 1000 mg/kg dose.
authors.affiliation: Division of Medicine, Indian Veterinary Research Institute, Izatnagar.
authors.forename: T S
authors.initials: TS
authors.lastname: Talakal
authors.forename: S K
authors.initials: SK
authors.lastname: Dwivedi
authors.forename: S R
authors.initials: SR
authors.lastname: Sharma
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D007194:India; D008297:Male; D008515:Medicine, Ayurvedic; D051379:Mice; D018512:Parasitemia / Q000188:drug therapy*; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal; D014345:Trypanosoma / Q000187:drug effects*; D014352:Trypanosomiasis / Q000188:drug therapy*
chemical_list: D010936:Plant Extracts