title: Transforming growth factor-beta 1 promotes re-elongation of injured axons of cultured rat hippocampal neurons.
abstract: Transforming growth factor-beta 1 (TGF-beta 1) is highly expressed in neural tissues following brain injuries. To determine a role of TGF-beta 1 in neural pathologies, axons of cultured rat hippocampal neurons were cut by local irradiation of laser beam, and the effect of TGF-beta 1 on neurite regeneration following axotomy was investigated. The axonal growth was stopped by laser irradiation, but addition of TGF-beta 1 remarkably promoted the axonal re-elongation from the injured site. The effect of TGF-beta 1 was concentration dependent and seen maximally at a concentration of 1 ng/ml. These results suggest that TGF-beta 1 has a capability of promoting axonal regeneration of brain neurons after lesioning.
authors.affiliation: Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Abe
authors.forename: P J
authors.initials: PJ
authors.lastname: Chu
authors.forename: A
authors.initials: A
authors.lastname: Ishihara
authors.forename: H
authors.initials: H
authors.lastname: Saito
mesh_terms: D000818:Animals; D001369:Axons / Q000187:drug effects*; D002478:Cells, Cultured / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000187:drug effects*; D051381:Rats; D016212:Transforming Growth Factor beta / Q000494:pharmacology*
chemical_list: D016212:Transforming Growth Factor beta