title: Cocaine-induced microvascular vasoconstriction but differential systemic haemodynamic responses in Yucatan versus Yorkshire varieties of swine.
abstract: 1. Systemic and coronary haemodynamics were measured in 6 Yorkshire swine and 6 Yucatan miniature swine under isoflurane anaesthesia to investigate the influence of cocaine following its intravenous administration at 1, 3 and 7 mg kg-1. 2. Cocaine in Yorkshire swine decreased mean arterial pressure and rate pressure product (systolic pressure x heart rate), suggesting a cardiac depressant effect, whereas cocaine in Yucatan miniature swine increased these parameters, consistent with a hyperadrenergic state. 3. Cocaine in both Yorkshire swine and Yucatan miniature swine decreased coronary blood flow and coronary flow reserve, and increased coronary vascular resistance. 4. A modest generalized epicardial coronary artery constriction was observed by angiography, without evidence of focal spasm. 5. Our results confirm a marked vasoconstrictor effect of cocaine on the coronary arterial circulation, predominantly distal to the epicardial coronary arteries, but also indicate important differences in the systemic cardiovascular responses to the drug between two closely related strains of animals within the same species. Due to the similarities between the swine and human coronary arterial vasculature, we suggest that vasoconstriction in the coronary microcirculation may produce cardiac toxicity in man.
authors.affiliation: Charles A. Dana Research Institute and Harvard-Thorndike Laboratory of Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: L
authors.initials: L
authors.lastname: Miao
authors.forename: B D
authors.initials: BD
authors.lastname: Núñez
authors.forename: V
authors.initials: V
authors.lastname: Susulic
authors.forename: S
authors.initials: S
authors.lastname: Wheeler
authors.forename: J P
authors.initials: JP
authors.lastname: Carrozza
authors.forename: J N
authors.initials: JN
authors.lastname: Ross
authors.forename: J P
authors.initials: JP
authors.lastname: Morgan
mesh_terms: D000790:Angiocardiography; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003042:Cocaine / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D013045:Species Specificity; D013552:Swine; D013556:Swine, Miniature; D014655:Vascular Resistance / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
chemical_list: D014662:Vasoconstrictor Agents; D003042:Cocaine