Anti-emetic principles of Poria cocos.
The triterpenes isolated from P. cocos and their derivatives were examined for anti-emetic activity. Some of these triterpenes inhibited emetic action induced by oral administration of copper sulfate pentahydrate to leopard frog. The triterpenes having an exomethylene group at C-24 showed anti-emetic activity to frogs.
Tai
T
T
Central Research Laboratory Kotaro Pharmaceutical Co. Ltd., Osaka, Japan.
Akita
Y
Y
Kinoshita
K
K
Koyama
K
K
Takahashi
K
K
Watanabe
K
K
D000818:Animals; D000932:Antiemetics / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008516:Medicine, Chinese Traditional; D010946:Plants, Medicinal / Q000737:chemistry*; D011894:Rana pipiens; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*
D000932:Antiemetics; D014315:Triterpenes