title: An anti-CD3 epsilon serum detects T lymphocytes in paraffin-embedded pathological tissues in many animal species.
abstract: The in situ identification of T cells has been difficult and restricted to frozen tissue samples of a limited range of species. In this study, we demonstrate that an antiserum recognizing a phylogenetically conserved part of the CD3 epsilon cytoplasmic tail detects T cells of many avian and mammalian species in formalin-fixed paraffin-embedded tissue sections. This antiserum enables the morphological characterization of normal and pathological lymphoid tissues and lymphoid infiltrations in experimental work and in animal disease.
authors.affiliation: Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary. immun@everx.szbk.u-szeged.hu
authors.forename: G
authors.initials: G
authors.lastname: Keresztes
authors.forename: R
authors.initials: R
authors.lastname: Glávits
authors.forename: L
authors.initials: L
authors.lastname: Krenács
authors.forename: E
authors.initials: E
authors.lastname: Kurucz
authors.forename: I
authors.initials: I
authors.lastname: Andó
mesh_terms: D000818:Animals; D017252:CD3 Complex / Q000276:immunology*; D006801:Humans; D007158:Immunologic Techniques; D010232:Paraffin; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D017252:CD3 Complex; D010232:Paraffin