Regulation of Epstein-Barr virus latency by latent membrane protein 2.
Like other herpesviruses, Epstein-Barr virus persists in its host through its ability to establish a latent infection that periodically reactivates. Latent membrane protein 2A (LMP2A) regulates reactivation from latency by interfering with normal B cell signal transduction processes, and may define a new class of regulators of herpesvirus latency.
Longnecker
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Microbiology-Immunology Dept, Northwestern University Medical School, Chicago, IL 60611, USA. r-longnecker@nwu.edu
Miller
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CL
D000595:Amino Acid Sequence; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D015967:Gene Expression Regulation, Viral; D005814:Genes, Viral / Q000235:genetics*; D006566:Herpesviridae Infections / Q000276:immunology* / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000276:immunology* / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D015398:Signal Transduction; D014763:Viral Matrix Proteins / Q000235:genetics / Q000276:immunology*; D017735:Virus Latency / Q000502:physiology*
C037662:EBV-associated membrane antigen, Epstein-Barr virus; D014763:Viral Matrix Proteins