title: Isolated late asthmatic reaction after exposure to a high-molecular-weight occupational agent, subtilisin.
abstract: High-molecular-weight agents generally induce immediate asthmatic reactions. We report the case of a subject who experienced a reaction that started after the first hour following exposure to subtilisin, a high-molecular-weight occupational agent. Any occurrence of immediate reaction was ruled out by measuring both FEV1 and lung volumes every 10 min in the first hour. This reaction was IgE-mediated as shown by immediate skin reactivity and increased specific IgE levels.
authors.affiliation: Department of Chest Medicine, Sacré-Coeur Hospital, Montreal, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Lemière
authors.forename: A
authors.initials: A
authors.lastname: Cartier
authors.forename: J
authors.initials: J
authors.lastname: Dolovich
authors.forename: J L
authors.initials: JL
authors.lastname: Malo
mesh_terms: D000328:Adult; D001249:Asthma / Q000139:chemically induced* / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D005541:Forced Expiratory Volume; D006282:Health Personnel; D006801:Humans; D008297:Male; D008970:Molecular Weight; D009784:Occupational Diseases / Q000139:chemically induced* / Q000503:physiopathology; D016273:Occupational Exposure; D013381:Subtilisins / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D013381:Subtilisins