title: CYP2D6 genotyping in a Russian population using a novel approach for identification of the CYP2D6A mutation.
abstract: The frequency of 29A and 29B mutations in the CYP2D6 gene, the most common mutations among Caucasoid PM (debrisoquine 4-hydroxylase defficient) individuals, has been analyzed in the Russian population. For the detection of the 29A mutation, a new one-step ARMS PCR approach has been developed. The frequency of the 29B mutant allele in Russians appeared to be significantly lower than in other Caucasoid populations, and this observation can be explained by the mixed origin of the population inhabiting Russia. Comparative analysis of the mutation frequencies among individuals of various ages showed no age-related differences.
authors.affiliation: Petersburg Institute of Nuclear Physics, Gatchina, St. Petersburg region, 188350, Russia.
authors.forename: S N
authors.initials: SN
authors.lastname: Akhmedova
authors.forename: E A
authors.initials: EA
authors.lastname: Pushnova
authors.forename: S
authors.initials: S
authors.lastname: Anisimov
authors.forename: L A
authors.initials: LA
authors.lastname: Bogdanova
authors.forename: L K
authors.initials: LK
authors.lastname: Bova
authors.forename: E I
authors.initials: EI
authors.lastname: Schwartz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D005787:Gene Frequency; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008659:Metabolic Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D009154:Mutation; D016133:Polymerase Chain Reaction / Q000379:methods; D012426:Russia; D044465:White People / Q000235:genetics
chemical_list: D019389:Cytochrome P-450 CYP2D6