title: Clinical heparin coated cardiopulmonary bypass: reduction of systemic heparin requirements for redo cardiac surgery.
abstract: The authors compared blood loss, transfusion requirements, and heparin doses for reoperative cardiac surgery using either: a) a Duraflow (Baxter Corporation, Irvine, CA) heparin coated cardiopulmonary bypass (CPB) system or b) standard CPB. Twenty patients underwent redo cardiac surgery while supported with heparin coated CPB, and 17 patients underwent redo cardiac surgery with standard CPB. The following data are presented as mean +/- standard deviation. The heparin coated CPB circuit group received significantly less heparin than the standard CPB group (322 +/- 80 IU/kg versus 448 +/- 80 IU/kg, p < 0.01). There was no difference in blood loss in the first 24 postoperative hrs or mean transfusion requirements for the two groups. Despite the reduced dose of heparin, the mean activated clotting time in the heparin coated group was similar to the mean activated clotting time of the standard CPB group (577 +/- 98 sec versus 612 +/- 117 sec, p = ns). In conclusion, heparin coated CPB without reduced activated clotting time does not reduce transfusion requirements or blood loss in reoperative cardiac surgery. The heparin coated CPB system allows maintenance of the activated clotting time level despite reduced heparin doses.
authors.affiliation: Indiana/Ohio Heart, Fort Wayne 46804, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Ladowski
authors.forename: M H
authors.initials: MH
authors.lastname: Schatzlein
authors.forename: A C
authors.initials: AC
authors.lastname: Peterson
authors.forename: W P
authors.initials: WP
authors.lastname: Deschner
authors.forename: R
authors.initials: R
authors.lastname: Matheis
authors.forename: M
authors.initials: M
authors.lastname: Ellenwood
authors.forename: J
authors.initials: J
authors.lastname: Bach
authors.forename: L
authors.initials: L
authors.lastname: Moldovan
authors.forename: D
authors.initials: D
authors.lastname: McKamey
mesh_terms: D001803:Blood Transfusion; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D005069:Evaluation Studies as Topic; D005112:Extracorporeal Circulation; D005260:Female; D006493:Heparin / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D012086:Reoperation
chemical_list: D006493:Heparin