Effects of thiofedrine on platelet aggregation, thromboxane B2 and 6-keto-PGF1 alpha in rats.
Thiofedrine inhibited rat platelet aggregation and intraplatelet thromboxane B2 (TxB2) generation induced by arachidonic acid. The IC50 values were 0.18 and 0.21 mmol/l, respectively. Thiofedrine, 1.25-5.00 mg/kg i.v., showed a significant inhibition of rat platelet aggregation and intraplatelet TxB2 generation induced by arachidonic acid, with ID50 values of 2.4 and 3.3 mg/kg. Thiofedrine, 0.5-2.0 mg/kg i.v., reduced TxB2 generation but increased 6-keto-PGF1 alpha formation in rat plasma.
Qu
Y Z
YZ
Department of Pharmacology, Inner Mongolia Medical College, Huhhot, China.
Wang
Y E
YE
Li
X X
XX
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000818:Animals; D000991:Antithrombins / Q000494:pharmacology*; D016718:Arachidonic Acid / Q000494:pharmacology; D003864:Depression, Chemical; D005260:Female; D008297:Male; D010099:Oxyfedrine / Q000031:analogs & derivatives* / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013929:Thromboxane B2 / Q000096:biosynthesis* / Q000097:blood
D000991:Antithrombins; D010975:Platelet Aggregation Inhibitors; D016718:Arachidonic Acid; C088651:thiofedrine; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D010099:Oxyfedrine