Polymorphism of acute-phase serum amyloid A isoforms and amyloid resistance in wild-type Mus musculus czech.
Until CE/J mice and their offspring were characterized as amyloid-resistant, all mice were thought to be amyloid-susceptible to multiple injections of azocasein or a single injection of silver nitrate following administration of amyloid enhancing factor. We now report, for the first time, that wild-type Mus musculus czech and F1 hybrids bred by crossing M. musculus czech with amyloid-susceptible CBA/J mice are also amyloid resistant. Based on the derived amino acid sequences of two serum amyloid A (SAA) cDNA clones, we describe two unusual SAA gene isoforms in M. musculus czech, one of which differs from four previously characterized acute-phase apoSAA isoforms at several amino acid residues. Our findings support the hypothesis that protection against amyloid fibril formation in wild-type M. musculus czech mice and their offspring is linked to apoSAA gene mutations (molecular motif).
Cathcart
E S
ES
Edith Nourse Rogers Memorial Veterans Hospital, Bedford, Massachusetts 01730, USA.
Carreras
I
I
Elliott-Bryant
R
R
Liang
J S
JS
Gonnerman
W A
WA
Sipe
J D
JD
D000595:Amino Acid Sequence; D000686:Amyloidosis / Q000097:blood / Q000235:genetics*; D000818:Animals; D000835:Animals, Wild; D001483:Base Sequence; D003001:Cloning, Molecular; D003433:Crosses, Genetic; D017931:DNA Primers / Q000235:genetics; D005260:Female; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008969:Molecular Sequence Data; D009154:Mutation; D011110:Polymorphism, Genetic; D000685:Serum Amyloid A Protein / Q000235:genetics*
D017931:DNA Primers; D000685:Serum Amyloid A Protein