title: The effect of cholesterol absorption inhibition on low density lipoprotein cholesterol level.
abstract: The degree of serum cholesterol lowering by up to almost maximal inhibition of cholesterol absorption was tested during neomycin and neomycin + sitostanol treatment in six hypercholesterolemic men. Neomycin decreased cholesterol absorption efficiency by 49% and the combination by 79%, and serum cholesterol level by 27% and 36%, respectively. The correlation between the absorption percentage and low density lipoprotein (LDL) cholesterol was significant (r = 0.510), and the regression equation (y = 0.04x + 2.59) suggested that the mean LDL cholesterol content would be about 2.5 mmol/l at zero cholesterol absorption. In conclusion, in hypercholesterolemic subjects, the lowering of LDL cholesterol appears to be limited to a low normal range only by almost totally inhibiting cholesterol absorption.
authors.affiliation: Second Department of Medicine, University of Helsinki, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Gylling
authors.forename: T A
authors.initials: TA
authors.lastname: Miettinen
mesh_terms: D000042:Absorption; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D002784:Cholesterol / Q000378:metabolism*; D008078:Cholesterol, LDL / Q000097:blood*; D006801:Humans; D006937:Hypercholesterolemia / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009355:Neomycin / Q000494:pharmacology*; D012855:Sitosterols / Q000494:pharmacology*
chemical_list: D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D012855:Sitosterols; D002784:Cholesterol; C021255:stigmastanol; D009355:Neomycin