Keeping the centrosome cycle on track. Genome stability.
The protein kinase Mps1 and p53 both function in centrosome duplication and the spindle cell-cycle checkpoint. Defects in these functions can be potent sources of genomic instability by allowing mitosis to proceed with aberrant mitotic spindles.
Winey
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Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Campus Box 347, Boulder, 80309-0347, USA.
D000818:Animals; D018385:Centrosome; D016681:Genome, Fungal; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins; D016159:Tumor Suppressor Protein p53 / Q000502:physiology
D029701:Saccharomyces cerevisiae Proteins; D016159:Tumor Suppressor Protein p53; D011505:Protein-Tyrosine Kinases; D017346:Protein Serine-Threonine Kinases; C093416:MPS1 protein, S cerevisiae