title: Bacterial entry into epithelial cells: the paradigm of Shigella.
abstract: Shigella flexneri is a model for the entry of bacterial pathogens into nonphagocytic epithelial cells. On contact with the epithelial cell surface, the Ipa proteins are secreted from the bacterium. The Ipa complex then triggers a reorganization of the host-cell cytoskeleton leading to the formation of membrane ruffles, which engulf the bacterium.
authors.affiliation: Unité de Pathogénie Microbienne Moléculaire, Institut Pasteur, Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Ménard
authors.forename: C
authors.initials: C
authors.lastname: Dehio
authors.forename: P J
authors.initials: PJ
authors.lastname: Sansonetti
mesh_terms: D001422:Bacterial Adhesion / Q000235:genetics / Q000502:physiology; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology; D003599:Cytoskeleton / Q000382:microbiology; D004405:Dysentery, Bacillary / Q000209:etiology / Q000382:microbiology; D004848:Epithelium / Q000382:microbiology; D005798:Genes, Bacterial; D006367:HeLa Cells; D006801:Humans; D018832:Molecular Chaperones / Q000235:genetics / Q000502:physiology; D010957:Plasmids / Q000235:genetics; D012763:Shigella flexneri / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D015398:Signal Transduction; D014774:Virulence / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D018832:Molecular Chaperones; C094580:IpgC protein, Shigella