title: Formation of DNA-adducts by selected sex steroids in rat liver.
abstract: 1. We are reporting investigations into the potential of the steroid hormones chlormadinone acetate (CMA), cyproterone acetate (CPA), ethinylestradiol (EE2) gestodene (GEST), megestrol acetate (MGA), norethisterone acetate (NET-Ac), estradiol (E2), and progesterone (P) to form DNA-adducts in rat liver in vivo. 2. Compound-related DNA-adduct spots were detected in male and female rat liver following CMA, CPA, and MGA using the 32P-postlabeling-technique. Substance-specific DNA-adducts were also observed in male rats after administration of E2. The other compounds showed no DNA-adduct formation. After treatment with CMA, CPA or MGA, the relative adduct labeling (RAL) differed sex- and substance-specifically.
authors.affiliation: Research Laboratories, Schering Aktiengesellschaft, Berlin, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Feser
authors.forename: R S
authors.initials: RS
authors.lastname: Kerdar
authors.forename: H
authors.initials: H
authors.lastname: Blode
authors.forename: R
authors.initials: R
authors.lastname: Reimann
mesh_terms: D000818:Animals; D004247:DNA / Q000187:drug effects / Q000302:isolation & purification; D018736:DNA Adducts / Q000187:drug effects* / Q000378:metabolism; D004249:DNA Damage / Q000502:physiology; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010761:Phosphorus Radioisotopes; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics; D013256:Steroids / Q000633:toxicity*
chemical_list: D018736:DNA Adducts; D010761:Phosphorus Radioisotopes; D013256:Steroids; D004247:DNA