McArdle's disease with non-insulin-dependent diabetes mellitus: the beneficial effects of hyperglycemia and hyperinsulinemia for exercise intolerance.
A 64-year-old female with McArdle's disease and non-insulin-dependent diabetes mellitus (NIDDM) is reported. She had none of the characteristic symptoms of McArdle's disease such as muscle cramps but her serum creatine kinase level was elevated. Muscle biopsy with negative muscle phosphorylase staining showed McArdle's disease. Modified forearm ischemic exercise test was done at two conditions; fasting and two hours after a meal. When fasting, the level of lactic acid did not elevate after exercise. After a meal, however, the serum lactic acid level rose with the elevation of plasma glucose and IRI. Thus, we suggested that high plasma glucose and insulin due to NIDDM may induce blood-borne glucose uptake with exercise.
Yamauchi
A
A
Department of Internal Medicine, School of Medicine, Keio University, Tokyo.
Amano
K
K
Ichikawa
Y
Y
Nakamoto
S
S
Takei
I
I
Maruyama
H
H
Kono
N
N
Saruta
T
T
D001706:Biopsy; D001786:Blood Glucose / Q000032:analysis; D002544:Cerebral Infarction / Q000150:complications; D003402:Creatine Kinase / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D004435:Eating; D005080:Exercise Test; D005215:Fasting / Q000097:blood; D005260:Female; D006012:Glycogen Storage Disease Type V / Q000150:complications* / Q000175:diagnosis; D006019:Glycolysis; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology / Q000503:physiopathology*; D006946:Hyperinsulinism / Q000209:etiology / Q000503:physiopathology*; D019344:Lactic Acid / Q000378:metabolism*; D008875:Middle Aged; D009120:Muscle Cramp / Q000503:physiopathology; D009124:Muscle Proteins / Q000172:deficiency*; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology; D006005:Phosphorylases / Q000172:deficiency*; D005082:Physical Exertion
D001786:Blood Glucose; D009124:Muscle Proteins; D019344:Lactic Acid; D006005:Phosphorylases; D003402:Creatine Kinase