Identification of LytSR-regulated genes from Staphylococcus aureus.
In this report, the characterization of a Staphylococcus aureus operon containing two LytSR-regulated genes, lrgA and lrgB, is described. Sequence and mutagenesis studies of these genes suggest that lrgA encodes a murein hydrolase exporter similar to bacteriophage holin proteins while lrgB may encode a protein having murein hydrolase activity.
Brunskill
E W
EW
Program in Molecular and Cell Biology, University of Maryland, Baltimore County 21228, USA.
Bayles
K W
KW
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics*; D001433:Bacteriolysis / Q000235:genetics; D001483:Base Sequence; D001692:Biological Transport; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D008969:Molecular Sequence Data; D009238:N-Acetylmuramoyl-L-alanine Amidase / Q000096:biosynthesis / Q000235:genetics; D013211:Staphylococcus aureus / Q000201:enzymology / Q000235:genetics*; D014157:Transcription Factors
D001426:Bacterial Proteins; C093500:LytR protein, Staphylococcus aureus; C101904:LytS protein, Staphylococcus aureus; D014157:Transcription Factors; D009238:N-Acetylmuramoyl-L-alanine Amidase