title: Increased serum concentration of soluble CD14 is a prognostic marker in gram-positive sepsis.
abstract: Increased serum sCD14 concentrations are associated with poor outcome in Gram-negative sepsis and trauma patients. In the present study serum sCD14 concentrations were measured in patients with Gram-positive sepsis and compared with Gram-negative septic and nonseptic intensive care unit patients. Furthermore, serum sCD14 concentration was correlated with patient's outcome. Serum samples of 28 Gram-positive (8 nonsurvivors/20 survivors) and 10 Gram-negative bacteriemic patients (3 nonsurvivors/7 survivors) were obtained at the day they met the sepsis criteria defined by Bone et al. (Day 0) and at Days 4 and 7 and compared with 10 nonseptic ICU patients and 10 healthy volunteers. Serum concentrations of sCD14 were measured by ELISA. Significantly higher sCD14 serum concentrations were found on Days 4 and 7 in Gram-positive nonsurvivors than in Gram-positive survivors (Day 4: 5.85 +/- 0.48 vs 4.07 +/- 0.43 microgram/ml, P < 0.05; Day 7: 6.12 +/- 0.46 vs 3.53 +/- 0.33 microgram/ml, P < 0.01). In addition, sCD14 concentrations of Gram-positive nonsurvivors were significantly higher than those of nonseptic ICU patients and healthy volunteers at any time of observation. However, no significant difference was calculated between Gram-positive and Gram-negative patients. Summarizing our results, the serum level of sCD14 could be proven to be a good prognostic marker in the course of Gram-positive sepsis. Increased levels are associated with a high mortality.
authors.affiliation: Department of Internal Medicine 1, University of Vienna Medical School, Austria.
authors.forename: H
authors.initials: H
authors.lastname: Burgmann
authors.forename: S
authors.initials: S
authors.lastname: Winkler
authors.forename: G J
authors.initials: GJ
authors.lastname: Locker
authors.forename: E
authors.initials: E
authors.lastname: Presterl
authors.forename: K
authors.initials: K
authors.lastname: Laczika
authors.forename: T
authors.initials: T
authors.lastname: Staudinger
authors.forename: S
authors.initials: S
authors.lastname: Knapp
authors.forename: F
authors.initials: F
authors.lastname: Thalhammer
authors.forename: C
authors.initials: C
authors.lastname: Wenisch
authors.forename: K
authors.initials: K
authors.lastname: Zedwitz-Liebenstein
authors.forename: M
authors.initials: M
authors.lastname: Frass
authors.forename: W
authors.initials: W
authors.lastname: Graninger
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000097:blood; D016908:Gram-Positive Bacterial Infections / Q000097:blood*; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012995:Solubility
chemical_list: D015415:Biomarkers; D018950:Lipopolysaccharide Receptors