title: Improvement of some pharmaceutical properties of drugs by cyclodextrin complexation. Part 6: Ampicillin.
abstract: The potentiality of interaction of ampicillin with beta-cyclodextrin (beta-CD) was investigated by spectrophotometric and vapour pressure osmometric methods. The results revealed formation of a two-to-one inclusion complex of the drug in beta-CD. Complexation of the drug with beta-CD was found to increase both the solubility as well as the dissolution rate of the drug. On the other hand, assessment of bioavailability in human subjects depicted highly significant increase in both the rate and extent of absorption of the drug.
authors.affiliation: Department of Pharmaceutical Sciences, National Research Centre, Dokki, Cairo, Egypt.
authors.forename: H O
authors.initials: HO
authors.lastname: Ammar
authors.forename: S A
authors.initials: SA
authors.lastname: el-Nahhas
authors.forename: M M
authors.initials: MM
authors.lastname: Ghorab
mesh_terms: D000277:Adjuvants, Pharmaceutic; D000328:Adult; D000667:Ampicillin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology*; D001682:Biological Availability; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003505:Cyclodextrins; D004355:Drug Stability; D005260:Female; D006801:Humans; D008297:Male; D009997:Osmotic Pressure; D010406:Penicillins / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000277:Adjuvants, Pharmaceutic; D003505:Cyclodextrins; D010406:Penicillins; D000667:Ampicillin