The human early pregnancy factor/chaperonin 10 gene family.
cDNA clones corresponding to the sequence for human early pregnancy factor were isolated from a human melanoma library and hybridized to DNA digested with four restriction enzymes obtained from twelve different subjects. Up to 20 cross hybridizing bands were observed. When hybridized to metaphase spreads from four different humans, significant signals were present in nine locations, on eight different chromosome arms. These results suggest that the early pregnancy factor gene is a member of a large gene family. The coding sequence for early pregnancy factor has a high degree of homology with the sequence for human chaperonin 10, and the gene family described here should contain the genes for both of these proteins.
Summers
K M
KM
Department of Surgery, University of Queensland, Royal Brisbane Hospital, Australia.
Murphy
R M
RM
Webb
G C
GC
Peters
G B
GB
Morton
H
H
Cassady
A I
AI
Cavanagh
A C
AC
D015139:Blotting, Southern; D018835:Chaperonin 10 / Q000235:genetics*; D002874:Chromosome Mapping; D018076:DNA, Complementary / Q000737:chemistry; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000235:genetics*; D016366:Open Reading Frames; D010455:Peptides / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011257:Pregnancy Proteins; D015183:Restriction Mapping; D013491:Suppressor Factors, Immunologic; D014407:Tumor Cells, Cultured
D018835:Chaperonin 10; D018076:DNA, Complementary; D010455:Peptides; D011257:Pregnancy Proteins; D013491:Suppressor Factors, Immunologic; C025124:early pregnancy factor