Enhanced oxidative killing of azole-resistant Candida glabrata strains with ERG11 deletion.
The susceptibility of genetically defined Candida glabrata strains to killing by H2O2 and neutrophils was assessed. Fluconazole-susceptible L5L and L5D strains demonstrated survival rates higher than those of two fluconazole-resistant strains lacking the ERG11 gene coding for 14 alpha-demethylase. Fluconazole resistance can occur by mechanisms which increase fungal susceptibility to oxidative killing by H2O2 and neutrophils.
Kan
V L
VL
Infectious Diseases Section (151B), Veterans Affairs Medical Center, Washington, DC 20422, USA.
Geber
A
A
Bennett
J E
JE
D000935:Antifungal Agents / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000235:genetics*; D002478:Cells, Cultured; D004352:Drug Resistance, Microbial; D017353:Gene Deletion; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology; D016877:Oxidants / Q000494:pharmacology*
D000935:Antifungal Agents; D001393:Azoles; D016877:Oxidants; D006861:Hydrogen Peroxide