title: Changes in the management of critical limb ischaemia.
abstract: A prospective study of all patients with critical limb ischaemia (CLI) who presented to a single vascular unit was undertaken for a 12-month period. There were 222 referrals in 188 patients, 80.2 per cent of which were emergency or urgent admissions. The majority (72.5 per cent) were initially investigated with colour duplex scanning to characterize the arterial lesion. Diagnostic angiography was performed in 35.1 per cent. An attempt at revascularization was made in 73.0 per cent of cases using percutaneous transluminal angioplasty (PTA) in 42.3 per cent, surgery in 24.3 per cent, and a combination of surgery and PTA in 6.3 per cent. Primary major amputation was required in 22 cases (9.9 per cent) and conservative treatments were used in 38 (17.1 per cent). The in-hospital mortality rate was 10 per cent with a limb salvage rate of 79 per cent. Diabetes was an independent risk factor for amputation (odds ratio 2.4, 95 per cent confidence interval 1.22-4.79, P = 0.012). Median hospital stay was much shorter for patients treated by PTA (4.5 days) than surgery (16 days) or primary amputation (18 days). The complication rate of PTA requiring surgery was 5.5 per cent. CLI represents a large non-elective workload for a vascular unit. The increasing use of non-invasive duplex assessment and angioplasty plays a major part in the successful management of these patients.
authors.affiliation: Department of Surgery, University of Leicester, Leicester Royal Infirmary, UK.
authors.forename: K
authors.initials: K
authors.lastname: Varty
authors.forename: S
authors.initials: S
authors.lastname: Nydahl
authors.forename: P
authors.initials: P
authors.lastname: Butterworth
authors.forename: M
authors.initials: M
authors.lastname: Errington
authors.forename: A
authors.initials: A
authors.lastname: Bolia
authors.forename: P R
authors.initials: PR
authors.lastname: Bell
authors.forename: N J
authors.initials: NJ
authors.lastname: London
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical; D000800:Angioplasty, Balloon; D016638:Critical Illness; D004630:Emergencies; D005260:Female; D017052:Hospital Mortality; D006760:Hospitalization; D006801:Humans; D007511:Ischemia / Q000000981:diagnostic imaging / Q000601:surgery / Q000628:therapy*; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D018616:Ultrasonography, Doppler, Duplex