title: Splenic abscesses and abdominal tuberculosis in patients with AIDS.
abstract: Tuberculous splenic abscesses do virtually not occur in immunocompetent patients. Tuberculous abscesses have been reported only from areas, where the prevalence of both HIV infection and tuberculosis is very high such as Central Africa. In our institution two of seven patients with AIDS and disseminated tuberculosis who were treated during the year 1994 developed tuberculous splenic abscesses. Both patients were resident in Central Europe and had fever and weight loss prior to admission. Multiple hypoechoic lesions up to 1.5 cm in diameter developed in the spleen of both patients on day 11 and 16 after admission, respectively. Initially no symptoms related to the splenic involvement and no leucocytosis were seen in both patients. One patient developed leucocytosis and left sided flank pain caused by a subtotal splenic abscess because the diagnosis and therapy of tuberculosis was delayed. Both patients responded promptly to triple drug antituberculous therapy without surgical intervention. We conclude that also in European patients multiple hypoechoic/hypodense lesions in the spleen of HIV positive patients are highly suggestive of disseminated tuberculosis. Follow-up by ultrasound may help to establish the correct diagnosis and may further prevent unnecessary complications in these patients.
authors.affiliation: Department of General Internal Medicine, University of Bonn.
authors.forename: C
authors.initials: C
authors.lastname: Reichel
authors.forename: A
authors.initials: A
authors.lastname: Theisen
authors.forename: J K
authors.initials: JK
authors.lastname: Rockstroh
authors.forename: H
authors.initials: H
authors.lastname: Müller-Miny
authors.forename: U
authors.initials: U
authors.lastname: Spengler
authors.forename: T
authors.initials: T
authors.lastname: Sauerbruch
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000188:drug therapy; D018784:Abdominal Abscess / Q000175:diagnosis* / Q000188:drug therapy; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011477:Sex Work; D015819:Substance Abuse, Intravenous / Q000150:complications; D014057:Tomography, X-Ray Computed; D014376:Tuberculosis / Q000175:diagnosis* / Q000188:drug therapy; D014400:Tuberculosis, Splenic / Q000175:diagnosis* / Q000188:drug therapy; D014463:Ultrasonography
chemical_list: D000995:Antitubercular Agents