title: Sequence and genomic organization of GBV-C: a novel member of the flaviviridae associated with human non-A-E hepatitis.
abstract: Recently, sequences from a novel virus, termed GB virus C (GBV-C), were identified in serum from several patients with cryptogenic hepatitis. In the present study, the nucleotide sequence of this virus has been extended to near-genome length. GBV-C encodes a putative single large polyprotein in which the structural proteins are positioned at the N-terminal end, with the non-structural proteins located at the C-terminal end. Amino acid sequence analysis of this large polyprotein reveals the presence of protease, helicase, and replicase motifs. Sequence alignments of the polyprotein followed by phylogenetic analyses suggest that GBV-C is a member of the Flaviviridae, most closely related to the recently described GB virus A.
authors.affiliation: Virus Discovery Group, Abbott Laboratories, North Chicago, Illinois, USA.
authors.forename: T P
authors.initials: TP
authors.lastname: Leary
authors.forename: A S
authors.initials: AS
authors.lastname: Muerhoff
authors.forename: J N
authors.initials: JN
authors.lastname: Simons
authors.forename: T J
authors.initials: TJ
authors.lastname: Pilot-Matias
authors.forename: J C
authors.initials: JC
authors.lastname: Erker
authors.forename: M L
authors.initials: ML
authors.lastname: Chalmers
authors.forename: G G
authors.initials: GG
authors.lastname: Schlauder
authors.forename: G J
authors.initials: GJ
authors.lastname: Dawson
authors.forename: S M
authors.initials: SM
authors.lastname: Desai
authors.forename: I K
authors.initials: IK
authors.lastname: Mushahwar
mesh_terms: D000595:Amino Acid Sequence; D010450:Endopeptidases / Q000378:metabolism; D018067:Flaviviridae / Q000737:chemistry / Q000145:classification / Q000235:genetics; D016679:Genome, Viral; D006518:Hepatitis Viruses / Q000737:chemistry / Q000145:classification / Q000235:genetics*; D006525:Hepatitis, Viral, Human / Q000821:virology*; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D011506:Proteins / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D014764:Viral Proteins / Q000378:metabolism
chemical_list: D011506:Proteins; D014764:Viral Proteins; D010450:Endopeptidases