title: Anti-inflammatory activity of flavonol glycosides from Erythrospermum monticolum depending on single or repeated local TPA administration.
abstract: Two anti-inflammatory principles were isolated from the methanol extract of the leaves of Erythrospermum monticolum (Flacourtiaceae). The isolation was based on a guided bioassay of the inhibitory activity on TPA-induced ear edema in mice. These compounds were identified as quercetin 3-O-xylosyl(1-->2) rhamnoside and quercetin 3-O-rhamnoside. In addition, their effects on a chronic topic inflammation model were evaluated.
authors.affiliation: Departament de Farmacologia, Universitat de València, Spain.
authors.forename: M
authors.initials: M
authors.lastname: del Carmen Recio
authors.forename: R M
authors.initials: RM
authors.lastname: Giner
authors.forename: S
authors.initials: S
authors.lastname: Máñez
authors.forename: A
authors.initials: A
authors.lastname: Talens
authors.forename: L
authors.initials: L
authors.lastname: Cubells
authors.forename: J
authors.initials: J
authors.lastname: Gueho
authors.forename: H R
authors.initials: HR
authors.lastname: Julien
authors.forename: K
authors.initials: K
authors.lastname: Hostettmann
authors.forename: J L
authors.initials: JL
authors.lastname: Rios
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004187:Disaccharides / Q000737:chemistry / Q000627:therapeutic use*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D051379:Mice; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D013755:Tetradecanoylphorbol Acetate / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004187:Disaccharides; C101971:quercetin 3-O-xylosyl-1-2-rhamnoside; C012526:quercitrin; D011794:Quercetin; D013755:Tetradecanoylphorbol Acetate