[Specifics of reproductive disorders and hormonal sensitivity of tumors in patients with "hormone-related neoplastic syndrome"].
Blood-serum levels of gonadotrophins and estradiol were assayed alongside with those of estradiol and progesterone receptors in the tissue of tumors of the breast, uterus, ovary and large bowel to establish general regularities of reproductive homeostasis in patients. The study was based on the assumption that risk of secondary tumor development is considerable in a patient who bears one of said malignancies. The effect of estrogen hormones was shown to be one of general causes of tumorigenesis. This is corroborated by enhanced hyperestrinism observed in cases of carcinoma of the corpus uteri as well as by certain data pointing to a reliable correlation between estrogen-stimulated synthesis of progesterone receptors and prognosis in patients with tumors of the breast, uterus and ovary. No estrogen dependence, however, was registered in patients with tumors of the bowel. Pathogenetic features shared by tumors of the large bowel and those of the reproductive system should probably be accounted for by disorders in metabolism.
Rybin
E P
EP
Tsyrlina
E V
EV
Gamaiunova
V B
VB
Vishnevskiĭ
A S
AS
Livshits
M A
MA
Semiglazov
V F
VF
Bershteĭn
L M
LM
Bokhman
I V
IV
D000328:Adult; D001943:Breast Neoplasms / Q000503:physiopathology; D003110:Colonic Neoplasms / Q000503:physiopathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000378:metabolism / Q000503:physiopathology*; D009378:Neoplasms, Multiple Primary / Q000378:metabolism / Q000503:physiopathology*; D010051:Ovarian Neoplasms / Q000503:physiopathology; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D012098:Reproduction; D014594:Uterine Neoplasms / Q000503:physiopathology
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone