Cytotoxic T lymphocyte responses to Epstein-Barr virus.
Epstein-Barr virus induces a potent cytotoxic T lymphocyte response in man that is preferentially directed towards a particular subset of the virus latent cycle antigens; the immunodominance of these proteins, apparent in both primary and memory responses, may reflect some differential access to the HLA class I processing pathway. Effector cells recognizing these immunodominant antigens can reverse the growth of virus-induced lymphoproliferative lesions in immunosuppressed patients; however, responses to some of the subdominant latent proteins will be needed to target other virus-positive tumours.
Rickinson
A B
AB
CRC Institute for Cancer Studies, Clinical Research Block, The Medical School, University of Birmingham, Edgbaston, B15 2TJ, UK. D.Williams.can@bham.ac.uk
Lee
S P
SP
Steven
N M
NM
D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*