The mechanism of coupling chemical and physical reactions by the calcium ATPase of sarcoplasmic reticulum and other coupled vectorial systems.
The coupling of the chemical reaction of ATP hydrolysis to the transport of calcium from the cytoplasm into the lumen of sarcoplasmic reticulum vesicles can be defined by a set of rules that define alternating changes in the specificities of the enzyme for catalysis of chemical and physical reactions.
Jencks
W P
WP
Graduate Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02254-9110, USA.
D000818:Animals; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D006801:Humans; D006868:Hydrolysis; D017136:Ion Transport; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*
D000252:Calcium-Transporting ATPases