title: Macronodular congenital adrenal hyperplasia in an adult with female pseudohermaphroditism.
abstract: We report a case of previously undiagnosed congenital adrenal hyperplasia presenting with virilisation in a 59-year-old woman. Biochemical analysis revealed C-21 hydroxylase deficiency. CT demonstrated adrenal hyperplasia and a 3.8-cm adrenal nodule, raising the possibility of the development of an autonomous adrenal adenoma or carcinoma. The adrenal nodule regressed significantly with oral replacement steroid therapy over the next 30 months, indicating it to be an ACTH-dependent hyperplastic nodule and thus avoiding the need for biopsy or surgical excision. Macronodular adrenal hyperplasia should be considered in the differential diagnosis of a patient presenting with virilisation and an adrenal mass.
authors.affiliation: Department of Diagnostic Radiology, Hope Hospital, Salford Royal NHS Trust, United Kingdom.
authors.forename: A M
authors.initials: AM
authors.lastname: Norris
authors.forename: J B
authors.initials: JB
authors.lastname: O'Driscoll
authors.forename: H
authors.initials: H
authors.lastname: Mamtora
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging; D000284:Administration, Oral; D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging; D000311:Adrenal Glands / Q000000981:diagnostic imaging; D000312:Adrenal Hyperplasia, Congenital / Q000175:diagnosis* / Q000000981:diagnostic imaging; D000324:Adrenocorticotropic Hormone / Q000502:physiology; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002277:Carcinoma / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D012734:Disorders of Sex Development / Q000175:diagnosis*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D014770:Virilism / Q000175:diagnosis*
chemical_list: D000893:Anti-Inflammatory Agents; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone