Prevention of sepsis in total joint arthroplasty.
Because of the adoption of effective prophylactic measures such as improved operating room techniques and systemic antibiotics, the prosthetic infection rate for artificial joint procedures has been reduced to 1-2%. However, because of the devastating results and large number of prosthetic procedures, prosthetic infection remains a major challenge. Common pathogens and mechanisms of infection, methods of preventing bacterial adherence to biomaterial surfaces, and clinical preventive strategies for prosthetic infections are discussed.
An
Y H
YH
Department of Orthopaedic Surgery, Medical University of South Carolina, Charleston 29425, USA.
Friedman
R J
RJ
D001422:Bacterial Adhesion; D004866:Equipment Contamination; D006801:Humans; D017053:Infection Control / Q000379:methods*; D007595:Joint Prosthesis / Q000009:adverse effects*; D016459:Prosthesis-Related Infections / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D018805:Sepsis / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*