The design and engineering of nucleic acid nanoscale assemblies.
It is possible to design DNA molecules that can form unusual structures and topologies. Stable DNA-branched junctions have been used to construct polyhedral catenated molecules with the connectivities of a cube and of a truncated octahedron. The truncated octahedron has been constructed following a solid-support-based methodology. Branched-DNA molecules are flexible, suggesting that triangular and deltahedral DNA objects should be favored as the components of two- and three-dimensional nucleic acid arrays. DNA polyhedra are complex catenanes. The engineering of single-stranded DNA knots and catenanes exploits the fact that a node can be equated with a half-turn of DNA.
Seeman
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NC
Department of Chemistry, New York University, New York, NY 10003, USA. Ned.Seeman@nyu.edu
D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D004277:DNA, Single-Stranded / Q000737:chemistry; D005818:Genetic Engineering / Q000379:methods*; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation
D004277:DNA, Single-Stranded; D004247:DNA