Hepatotoxicity of N, N-dimethylformamide in rats following intraperitoneal or inhalation routes of administration.
Male Sprague-Dawley rats were administered a single intraperitoneal injection of N, N-dimethylformamide (DMF, 0.01-1.5 g kg-1) or were exposed for 4 h to DMF vapours (75-900 ppm). The serum activities of the enzymes sorbitol deshydrogenase and glutamate deshydrogenase were used as indicators of liver damage, and were determined at 24, 48 or 72 h post-treatment. Following either route of administration DMF caused concentration-dependent elevations in enzyme activities, the maxima of which occurred later after administration of higher concentrations of DMF than after lower concentrations.
Roure
M B
MB
Institut National de Recherche et de Sécurité, Vandoeuvre, France.
Lambert
A M
AM
Cour
C
C
Bonnet
P
P
Saillenfait
A M
AM
D000280:Administration, Inhalation; D000818:Animals; D004126:Dimethylformamide / Q000008:administration & dosage / Q000633:toxicity*; D005969:Glutamate Dehydrogenase / Q000032:analysis; D007274:Injections, Intraperitoneal; D007064:L-Iditol 2-Dehydrogenase / Q000032:analysis; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D018675:Toxicity Tests
D004126:Dimethylformamide; D007064:L-Iditol 2-Dehydrogenase; D005969:Glutamate Dehydrogenase