Development of B-cell memory and effector function.
The past year has seen significant advances in our understanding of molecules that both positively and negatively regulate B- and T-cell responses. Of particular interest is the lethal phenotype of CTLA-4-deficient mice, which has illuminated the importance of downregulation of T-cell responses and the increasingly complicated role of CD40 and its ligand in directing both T- and B-cell priming.
Lane
P
P
Basel Institute for Immunology, Switzerland. lane@bii.ch
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D008213:Lymphocyte Activation; D008211:Lymphocyte Cooperation