title: [Small-cell lung cancer and subacute sensory neuropathy in a patient positive for the anti-Hu antigen].
abstract: We encountered a case of small-cell lung cancer in a patient with subacute sensory neuropathy that began 5 months before the cancer was diagnosed. A 60-year-old man complained of abnormalities in the functioning of his peripheral sensory systems (senses of pain, touch, position, and vibration). A chest X-ray film obtained on admission showed an anterior mediastinal tumor. The anti-Hu antibody was found in his serum. The diagnosis was small-cell lung cancer. Combination chemotherapy (cisplatin and irinotecan, CPT-11) was begun and the response was a complete remission. The symptoms of neuropathy continued. The anti-Hu antibody was useful in the diagnosis in the case of small-cell lung cancer combined with subacute sensory neuropathy.
authors.affiliation: First Department of Internal Medicine, Osaka City University Medical School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Okishio
authors.forename: S
authors.initials: S
authors.lastname: Kudoh
authors.forename: E
authors.initials: E
authors.lastname: Katsumoto
authors.forename: T
authors.initials: T
authors.lastname: Ohtsuka
authors.forename: S
authors.initials: S
authors.lastname: Shoji
authors.forename: T
authors.initials: T
authors.lastname: Fujii
authors.forename: H
authors.initials: H
authors.lastname: Kanazawa
authors.forename: K
authors.initials: K
authors.lastname: Hirata
authors.forename: N
authors.initials: N
authors.lastname: Kurihara
authors.forename: J
authors.initials: J
authors.lastname: Yoshikawa
mesh_terms: D000208:Acute Disease; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001323:Autoantibodies / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D002945:Cisplatin / Q000008:administration & dosage; D006801:Humans; D000077146:Irinotecan; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000209:etiology*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D014408:Biomarkers, Tumor; D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin