title: The effect of two toothpaste detergents on the frequency of recurrent aphthous ulcers.
abstract: The aim of the present clinical double-blind crossover study was to investigate the effect of two different toothpaste detergents, sodium lauryl sulfate (SLS) and cocoamidopropyl betaine (CAPB), as compared with a detergent-free paste, on 30 patients with frequent occurrences of recurrent aphthous ulcers. The study consisted of three 6-week periods during which the patients brushed twice daily with the different test toothpastes. The localization and number of new ulcers were assessed. A significantly higher frequency of aphthous ulcers was demonstrated when the patients brushed with an SLS- than with a CAPB-containing or a detergent-free placebo paste. An SLS-free toothpaste may thus be recommended for patients with recurrent aphthous ulcers.
authors.affiliation: Department of Oral Surgery and Oral Medicine, Dental Faculty, University of Oslo, Norway.
authors.forename: B B
authors.initials: BB
authors.lastname: Herlofson
authors.forename: P
authors.initials: P
authors.lastname: Barkvoll
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001622:Betaine / Q000031:analogs & derivatives* / Q000494:pharmacology; D002648:Child; D018592:Cross-Over Studies; D003902:Detergents / Q000009:adverse effects / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D012008:Recurrence; D012967:Sodium Dodecyl Sulfate / Q000009:adverse effects / Q000494:pharmacology*; D013281:Stomatitis, Aphthous / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D013501:Surface-Active Agents / Q000009:adverse effects / Q000494:pharmacology*; D014100:Toothpastes / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D003902:Detergents; D010919:Placebos; D013501:Surface-Active Agents; D014100:Toothpastes; D012967:Sodium Dodecyl Sulfate; D001622:Betaine; C077055:cocamidopropyl betaine