title: Haemophilus influenzae type b (HIB)-conjugate immunization before bone marrow harvest in autologous bone marrow transplantation.
abstract: Immune reconstitution following autologous bone marrow transplantation (ABMT) is characterized by defects in B cell and T cell function and loss of specific antibody. In the late post-transplant period, patients are at risk for infections with polysaccharide encapsulated organisms and respond poorly to polysaccharide vaccines. We examined whether immunizing ABMT patients before bone marrow (BM) harvest enhanced the early recovery of specific antibody. Twelve patients were immunized before BM harvest with Haemophilus influenzae type b (HIB)-conjugate, tetanus toxoid and polysaccharide pneumococcal vaccines. Forty-one comparable ABMT patients not immunized prior to BM harvest were also studied. Following ABMT, both groups of patients were immunized with HIB-conjugate and tetanus toxoid vaccines at 3, 6, 12 and 24 months and with pneumococcal vaccine at 12 and 24 months. Patients immunized before BM harvest had higher HIB antibody concentrations during the first 2 years post-transplant, the differences reaching significance at 3 months (P = 0.0001) and following the 24-month dose (P = 0.048). Tetanus toxoid antibody concentrations were also significantly higher at 3 months (P = 0.001) and 6 months (P = 0.032) in patients immunized before BM harvest. There were no differences in pneumococcal antibody concentrations between the two groups. Immunization of patients before bone marrow harvest resulted in higher anti-HIB antibody concentrations following ABMT and may be an effective strategy to prevent infectious complications.
authors.affiliation: Laboratory of Infectious Diseases; Dana-Farber Cancer Institute, Boston, MA 02115, USA.
authors.forename: D C
authors.initials: DC
authors.lastname: Molrine
authors.forename: E C
authors.initials: EC
authors.lastname: Guinan
authors.forename: J H
authors.initials: JH
authors.lastname: Antin
authors.forename: C
authors.initials: C
authors.lastname: Wheeler
authors.forename: S K
authors.initials: SK
authors.lastname: Parsons
authors.forename: H J
authors.initials: HJ
authors.lastname: Weinstein
authors.forename: C
authors.initials: C
authors.lastname: McGarigle
authors.forename: P
authors.initials: P
authors.lastname: Blanding
authors.forename: N R
authors.initials: NR
authors.lastname: Phillips
authors.forename: A
authors.initials: A
authors.lastname: Ciamarra
authors.forename: S
authors.initials: S
authors.lastname: George
authors.forename: D M
authors.initials: DM
authors.lastname: Ambrosino
mesh_terms: D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D016667:Bacterial Capsules; D001424:Bacterial Infections / Q000517:prevention & control; D001428:Bacterial Vaccines / Q000276:immunology; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D005260:Female; D018073:Haemophilus Vaccines / Q000276:immunology*; D006801:Humans; D007114:Immunization; D008297:Male; D008875:Middle Aged; D022242:Pneumococcal Vaccines; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D013745:Tetanus Toxoid / Q000276:immunology; D014182:Transplantation, Autologous; D018074:Vaccines, Conjugate / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; D022242:Pneumococcal Vaccines; D011135:Polysaccharides, Bacterial; D013745:Tetanus Toxoid; D018074:Vaccines, Conjugate