title: Recurrent brain metastases.
abstract: Metastases of the brain are the most frequent metastatic neurologic complication of systemic cancer and are second only to metabolic encephalopathies as a cause of central nervous system dysfunction in cancer patients. Despite recent significant advances in the diagnosis and treatment of metastases to the brain, many patients will suffer from recurrence. Future advances in the use of chemotherapy, radiosurgery, and newer cancer therapy techniques may lead to further increases in the efficacy of treatment for recurrent brain metastases.
authors.affiliation: Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: E
authors.initials: E
authors.lastname: Alexander
authors.forename: J S
authors.initials: JS
authors.lastname: Loeffler
mesh_terms: D001932:Brain Neoplasms / Q000150:complications / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D003131:Combined Modality Therapy; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000150:complications / Q000175:diagnosis / Q000628:therapy