Suppression of sympathetic nervous system attenuates the development of two-kidney, one-clip Goldblatt hypertension.
OBJECTIVE
This study tried to assess the possible contribution of the sympathetic nervous system to the onset of two-kidney, one-clip (2K-1C) Goldblatt hypertension.


METHODS
The effect of chlorisondamine administration with or without subsequent splanchnicotomy on the development of hypertension was examined in 2K-1C rats with special reference to norepinephrine synthesis.


RESULTS
The 2K-1C rats were treated either with chlorisondamine or chlorisondamine plus subsequent splanchnicotomy, so that the development of hypertension was effectively arrested for 4 weeks. An apparently high rate of release of norepinephrine in 2K-1C rats was reduced by treatment with chlorisondamine plus splanchnicotomy. A similar trend was also seen in plasma norepinephrine concentration and norepinephrine clearance, to a lesser extent. There were significant positive relationships between percent change of systolic blood pressure and apparent rate of release of norepinephrine, plasma norepinephrine concentration and norepinephrine clearance in 2K-1C rats and 2K-1C + chlorisondamine + splanchnicotomy rats. There were no significant relationships in these parameters in sham-treated rats.


CONCLUSIONS
Increased sympathetic innervation appears to participate in the development of 2K-1C Goldblatt hypertension.
Nakada
T
T
Department of Urology, Yamagata University, School of Medicine, Japan.
Kubota
Y
Y
Suzuki
H
H
Sasagawa
I
I
Watanabe
M
M
Ishigooka
M
M
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D002714:Chlorisondamine / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006978:Hypertension, Renovascular / Q000097:blood / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D009638:Norepinephrine / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D013153:Splanchnic Nerves / Q000601:surgery
D000959:Antihypertensive Agents; D002714:Chlorisondamine; D009638:Norepinephrine