title: Sequence of the cDNA for the liver/non-muscle isoform of mouse cytochrome-c oxidase subunit VIII.
abstract: We have isolated and sequenced the cDNA for the liver (L) or non-muscle isoform of mouse cytochrome-c oxidase subunit VIII (COX VIII-L). Comparison of deduced COX VIII-L protein sequences from three mammalian species indicated that the human gene has sustained more amino acid replacement substitutions than either the mouse or the cow. The most highly conserved regions of this subunit are the N-terminal presequence and the C-terminal domain of the mature protein.
authors.affiliation: Department of Anatomy and Cell Biology, University of Michigan, Ann Arbor 48109, USA.
authors.forename: G J
authors.initials: GJ
authors.lastname: Makris
authors.forename: M I
authors.initials: MI
authors.lastname: Lomax
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D003001:Cloning, Molecular; D017124:Conserved Sequence / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics*; D003576:Electron Transport Complex IV / Q000737:chemistry / Q000235:genetics*; D019143:Evolution, Molecular; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000235:genetics*; D008099:Liver / Q000201:enzymology*; D051379:Mice; D008969:Molecular Sequence Data; D017421:Sequence Analysis; D017386:Sequence Homology, Amino Acid
chemical_list: D018076:DNA, Complementary; D007527:Isoenzymes; D003576:Electron Transport Complex IV