New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors.
Two new hydrolyzable tannins, shephagenins A and B, were isolated along with hippophaenin A and strictinin from the leaf extract of Shepherdia argentea, which showed a remarkable inhibitory activity against human immunodeficiency virus (HIV)-1 reverse transcriptase. Their structures, having a gluconic acid core, have been elucidated on the basis of spectroscopic and chemical methods. The inhibitory effect of the leaf extract on HIV-1 reverse transcriptase was found to be due to tannins, and their activities were stronger than that of (-)-epigallocatechin gallate as a positive control.
Yoshida
T
T
Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Ito
H
H
Hatano
T
T
Kurata
M
M
Nakanishi
T
T
Inada
A
A
Murata
H
H
Inatomi
Y
Y
Matsuura
N
N
Ono
K
K
Nakane
H
H
Noda
M
M
Lang
F A
FA
Murata
J
J
D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology*; D006801:Humans; D006868:Hydrolysis; D047348:Hydrolyzable Tannins; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D018894:Reverse Transcriptase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D013634:Tannins / Q000302:isolation & purification / Q000494:pharmacology*
D000998:Antiviral Agents; D047348:Hydrolyzable Tannins; D018894:Reverse Transcriptase Inhibitors; D013634:Tannins; C102400:shephagenin A; C102401:shephagenin B