Augmentation of leukocyte count with G-CSF in a patient with neutropenia before In-111 WBC scintigraphy.
Neutropenia with persistent fevers and a wound infection developed in a patient with AIDS after an uncomplicated hysterectomy. After a single dose of G-CSF (granulocyte-colony stimulating factor), the WBC count transiently recovered, and an In-111 labeled WBC scan was successfully performed to exclude an intra-abdominal source of infection and to implicate the superficial wound as a source of her fevers. The patient underwent wound debridement the next day and made an uneventful recovery. This article describes a potential new role for G-CSF, namely enhancement of the WBC count in patients with neutropenia who are referred for In-111 WBC imaging to improve diagnostic yield.
Lin
S
S
Department of Radiology, Harbor-UCLA Medical Center, Torrance, USA.
Marcus
C S
CS
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000150:complications*; D000328:Adult; D005260:Female; D005335:Fever of Unknown Origin / Q000209:etiology; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007044:Hysterectomy; D007205:Indium Radioisotopes; D007958:Leukocyte Count; D007962:Leukocytes; D009503:Neutropenia / Q000209:etiology / Q000628:therapy*; D011877:Radionuclide Imaging; D013530:Surgical Wound Infection / Q000150:complications / Q000000981:diagnostic imaging*
D007205:Indium Radioisotopes; D016179:Granulocyte Colony-Stimulating Factor