Physiology and biochemistry of the kidney vacuolar H+-ATPase.
Vacuolar H+-ATPases have an essential role in renal hydrogen ion secretion in the proximal tubule, collecting duct, and other segments of the nephron. Control of H+ transport is achieved by variations in the intrinsic properties of the renal H+-ATPases and by several cellular regulatory mechanisms, including redistribution of the enzyme both by vesicular traffic and regulated assembly and disassembly, and cytosolic regulatory proteins that interact directly with H+-ATPase. These mechanisms may provide a means for fine control of net acid excretion and for regulating vacuolar H+-ATPases residing on the plasma membrane independently from those in intracellular compartments.
Gluck
S L
SL
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Underhill
D M
DM
Iyori
M
M
Holliday
L S
LS
Kostrominova
T Y
TY
Lee
B S
BS
D000818:Animals; D006801:Humans; D007668:Kidney / Q000201:enzymology* / Q000648:ultrastructure; D006180:Proton-Translocating ATPases / Q000378:metabolism*; D014617:Vacuoles / Q000201:enzymology / Q000648:ultrastructure
D006180:Proton-Translocating ATPases