The gene for calcium-modulating cyclophilin ligand (CAMLG) is located on human chromosome 5q23 and a syntenic region of mouse chromosome 13.
The CAMLG gene encodes a novel cyclophilin B-binding protein called calcium-modulating cyclophilin ligand, which appears to be involved in the regulation of calcium signaling in T lymphocytes and other cells. The murine homolog, Caml, was localized by interspecific backcross analysis to the middle of chromosome 13. By fluorescence in situ hybridization, this gene was localized to human chromosome 5 in a region (q23) known to be syntenic to mouse chromosome 13. These results provide further evidence supporting the extensive homology between human chromosome 5q and mouse chromosome 13. In addition, the results will provide a basis for further evaluation of cytogenetic anomalies that may contribute to inherited defects in calcium signaling or immune system function.
Bram
R J
RJ
Department of Experimental Oncology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. bram@stjude.org
Valentine
V
V
Shapiro
D N
DN
Jenkins
N A
NA
Gilbert
D J
DJ
Copeland
N G
NG
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D005260:Female; D015894:Genome, Human; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
D048868:Adaptor Proteins, Signal Transducing; C089404:CAMLG protein, human; C490314:Caml protein, mouse; D002352:Carrier Proteins