Low-frequency stimulation does not readily cause long-term depression or depotentiation in the dentate gyrus of awake rats.
The ability of low-frequency stimulation (LFS) to induce either long-term depression (LTD) or depotentiation was assessed for perforant path synapses in the dentate gyrus of awake, adult rats. Neither LFS at 1 Hz (100 or 900 pulses) nor LFS at 3 Hz (900 pulses) was sufficient to produce either LTD or depotentiation. LFS at 3 Hz did produce a transient response depression of previously potentiated synapses, but this lasted less than 24 h and was secondary to seizure-like afterdischarges. We conclude that the LFS protocols so effective at eliciting LTD and depotentiation in area CA1 are ineffective for perforant path synapses in the dentate gyrus.
Abraham
W C
WC
Department of Psychology, University of Otago, Dunedin, New Zealand. cabraham@otago.ac.nz
Mason-Parker
S E
SE
Logan
B
B
D000818:Animals; D018891:Dentate Gyrus / Q000502:physiology*; D004558:Electric Stimulation / Q000379:methods; D004594:Electrophysiology; D017774:Long-Term Potentiation; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000503:physiopathology; D013569:Synapses / Q000502:physiology; D013997:Time Factors