title: Can the wound healing process be improved by vitamin supplementation? Experimental study on humans.
abstract: The improvement of the wound healing process in humans by vitamin supplements is still controversial because of the lack of a clearly demonstrated correlation with the mechanical properties of scars.
  
  
  OBJECTIVE
  The aim of this work was to study the effects of high doses of ascorbic acid (AA) and pantothenic acid (PA) on the wound healing process of human skin.
  
  
  METHODS
  Two groups of patients undergoing surgery for tattoo removal by the successive resection procedure received AA (1 or 3 g/day) and PA (0.2 or 0.9 g/day). More than 80 mechanical, biological and histological parameters were investigated in both preoperated skin and the scars.
  
  
  RESULTS
  The breaking energy of scars was higher in group 2, and energy and treatment were directly correlated (p = 0.006). Mg and Mn significantly rose in group 2 whereas Fe decreased in a dose-dependent manner. Intragroup comparison showed patient and treatment effects for Mg, a time.treatment effect for Cu and a treatment effect for Fe.
  
  
  CONCLUSIONS
  The degree and rapidity of variations rather than the variations of the absolute values themselves of fibroblasts, hydroxyproline, Fe, Cu and Mg are significantly related to the enhancement of the mechanical properties of scars. From this study, it may be assumed that in order to obtain 'better', more solid and resistant scars, the decrease of Fe must be quick and acute in order to avoid the harmful effects of toxic radicals; the increase of Cu, Mg and Mn must be early and high in order to have more stable and solid collagen.
authors.affiliation: INSERM U61 et Laboratoire Pautrier, Chirurgie B, Hôpitaux Universitaires de Strasbourg, France.
authors.forename: F
authors.initials: F
authors.lastname: Vaxman
authors.forename: S
authors.initials: S
authors.lastname: Olender
authors.forename: A
authors.initials: A
authors.lastname: Lambert
authors.forename: G
authors.initials: G
authors.lastname: Nisand
authors.forename: J F
authors.initials: JF
authors.lastname: Grenier
mesh_terms: D001205:Ascorbic Acid / Q000097:blood / Q000494:pharmacology*; D002921:Cicatrix / Q000378:metabolism; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D006909:Hydroxyproline / Q000032:analysis; D007501:Iron / Q000032:analysis / Q000378:metabolism; D008274:Magnesium / Q000032:analysis / Q000378:metabolism; D008345:Manganese / Q000032:analysis / Q000378:metabolism; D010205:Pantothenic Acid / Q000494:pharmacology*; D012867:Skin / Q000737:chemistry; D014945:Wound Healing / Q000187:drug effects*; D015032:Zinc / Q000032:analysis / Q000378:metabolism
chemical_list: D010205:Pantothenic Acid; D008345:Manganese; D007501:Iron; D008274:Magnesium; D015032:Zinc; D001205:Ascorbic Acid; D006909:Hydroxyproline