Antioxidant activity of dioscorea and dehydroepiandrosterone (DHEA) in older humans.
Dioscorea is a yam steroid extract used in commercial steroid synthesis and consumed by people. DHEA is a steroid which declines with age, but without known activity. This study was designed to determine whether dioscorea supplementation could increase serum dehydroepiandrosterone sulfate (DHEAS) in humans and modulate lipid levels in older people. The subjects were selected volunteers aged 65-82 years. The serum DHEAS level, lipid peroxidation and lipid profile were assessed. Three weeks of dioscorea supplementation had no affect on serum DHEAS level. However DHEA intake of 85 mg/day increased serum DHEA levels 100.3%. DHEA and dioscorea significantly reduced serum lipid peroxidation, lowered serum triglycerides, phospholipid and increased HDL levels. Both DHEA and the steroid yam extract, dioscorea, have significant activities as antioxidant to modify serum lipid levels.
Araghiniknam
M
M
Arizona Prevention Center, University of Arizona, School of Medicine, Tucson 85724, USA.
Chung
S
S
Nelson-White
T
T
Eskelson
C
C
Watson
R R
RR
D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants; D003687:Dehydroepiandrosterone / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D010743:Phospholipids / Q000097:blood; D013256:Steroids / Q000008:administration & dosage / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
D000975:Antioxidants; D008055:Lipids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D010743:Phospholipids; D013256:Steroids; D014280:Triglycerides; D003687:Dehydroepiandrosterone