title: Age-associated changes in detrusor sensory function in women with lower urinary tract symptoms.
abstract: This study examined changes in bladder sensation which occur with age in women. 1381 women (age range 20-95 years, mean 54.9) with symptoms of lower urinary tract dysfunction underwent urodynamic study. The bladder capacity at which they first became aware of the desire to void was taken as a quantitative measure of bladder sensation. Maximum bladder capacity fell in the eighth and ninth decades (H = 95.84, df = 7, P = 0.00), but by contrast bladder capacity at first desire to void rose progressively in association with age, both in the group as a whole (H = 17.13, df = 7, P = 0.017) and in a subgroup with detrusor instability (n = 952, H = 15.42, df = 7, P = 0.032). This rise in capacity points to a decrease in bladder sensation in association with age. This is not due to neurological disease, anti-muscarinic drugs or oestrogens, as the median capacity at first desire to void of these three subgroups did not differ significantly from that of the group as a whole.
authors.affiliation: Department of Medicine, University College London Medical School, St. Pancras Hospital, UK.
authors.forename: D M
authors.initials: DM
authors.lastname: Collas
authors.forename: J G
authors.initials: JG
authors.lastname: Malone-Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D004967:Estrogens / Q000009:adverse effects; D005260:Female; D006801:Humans; D008875:Middle Aged; D009475:Neurons, Afferent / Q000502:physiology; D010275:Parasympathetic Nervous System / Q000502:physiology*; D012677:Sensation / Q000187:drug effects / Q000502:physiology*; D001743:Urinary Bladder / Q000294:innervation* / Q000503:physiopathology; D014555:Urination Disorders / Q000209:etiology / Q000503:physiopathology*; D014563:Urodynamics
chemical_list: D004967:Estrogens