Dietary raw versus retrograded resistant starch enhances apparent but not true magnesium absorption in rats.
Dietary raw (RS2) vs. retrograded resistant starch (RS3) raises apparent magnesium absorption in rats. The mechanism proposed is that RS2 enhances magnesium avaibility for absorption; it does this by increasing ileal solubility of magnesium due to a reduction in pH as a consequence of RS2 fermentation in the gut. The mechanism implies that dietary RS2 vs. RS3 would raise true magnesium absorption and stimulate reabsorption of endogenous magnesium, leading to a lower fecal excretion of endogenous magnesium. Dietary lactulose vs. glucose raises apparent magnesium absorption, and the mechanism proposed is similar to that for the stimulatory effect of RS2 vs. RS3. Thus, we measured in rats fed RS3, RS2, glucose or lactulose true magnesium absorption on the basis of the retention of the orally and intraperitoneally administered radiotracer 28Mg. Feeding rats RS2 instead of RS3 significantly enhanced apparent but not true magnesium absorption, because RS2 lowered fecal excretion of endogenous magnesium. When compared with dietary glucose, lactulose significantly raised both apparent and true magnesium absorption, but did not affect fecal excretion of endogenous magnesium. It is suggested that the proposed mechanism by which RS2 and lactulose would enhance magnesium absorption is disproved by the present data.
Heijnen
M L
ML
Department of Human Nutrition, Wageningen Agricultural University, The Netherlands.
van den Berg
G J
GJ
Beynen
A C
AC
D000042:Absorption / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001835:Body Weight / Q000502:physiology; D004032:Diet / Q000592:standards; D004040:Dietary Carbohydrates / Q000032:analysis / Q000494:pharmacology*; D004435:Eating / Q000502:physiology; D005243:Feces / Q000737:chemistry; D005285:Fermentation / Q000502:physiology; D005947:Glucose / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007082:Ileum / Q000378:metabolism / Q000502:physiology; D007792:Lactulose / Q000494:pharmacology; D008274:Magnesium / Q000032:analysis / Q000493:pharmacokinetics* / Q000652:urine; D008297:Male; D011868:Radioisotopes; D051381:Rats; D017208:Rats, Wistar; D013213:Starch / Q000737:chemistry / Q000494:pharmacology*
D004040:Dietary Carbohydrates; D011868:Radioisotopes; D007792:Lactulose; D013213:Starch; D008274:Magnesium; D005947:Glucose