BalI and MspI polymorphisms of the dopamine D3 receptor gene in African Blacks and Caucasians.
An exonic BalI polymorphism and an intronic MspI polymorphism of the dopamine D3 gene were genotyped in 101 Caucasians from the Alsace and in 56 people from the Congo. This is the first study of the BalI polymorphism in sub-Saharan Africa and the first population study of the MspI site. BalI allele 1 was rare in the Congo (0.12) whereas it is the most frequent allele in all studies in Europe and Asia. MspI allele 1 was also significantly less frequent in the Congolese (0.24) than in Caucasians (0.52). D3 gene alleles show different frequencies in sub-Saharan Africa and may be useful for population studies.
Crocq
M A
MA
Centre Hospitalier, FORENAP, Rouffach, France.
Buguet
A
A
Bisser
S
S
Burgert
E
E
Stanghellini
A
A
Uyanik
G
G
Dumas
M
M
Macher
J P
JP
Mayerova
A
A
D000483:Alleles; D000818:Animals; D001483:Base Sequence; D044383:Black People / Q000235:genetics*; D017931:DNA Primers; D015257:DNA-Cytosine Methylases / Q000378:metabolism*; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008969:Molecular Sequence Data; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050637:Receptors, Dopamine D3; D044465:White People / Q000235:genetics*
D017931:DNA Primers; C493593:DRD3 protein, human; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; C029641:DNA modification methylase HpaII; D015257:DNA-Cytosine Methylases; D015252:Deoxyribonucleases, Type II Site-Specific; C060616:TGGCCA-specific type II deoxyribonucleases