About the large fluctuations observed using gas-phase molecular dynamics in the K-ras gene containing a mismatch.
We describe how we can reduce the periodic bending motions in the simulation in vacuo of the molecular dynamics of a short DNA fragment containing the Gly 12 hot spot of the K-ras oncogene and having at its center a mismatch CA+.
Ouali
M
M
Unité de Physicochimie, URA 147 CNRS, Villejuif, France.
Pothier
J
J
Gabarro-Arpa
J
J
Le Bret
M
M
D001483:Base Sequence; D004247:DNA / Q000235:genetics; D011905:Genes, ras; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008969:Molecular Sequence Data
D004247:DNA