HIV-1, Vpr and the cell cycle.
The human immunodeficiency virus 1 (HIV-1) is a complex retrovirus with more genes than most retroviruses. One of these extra genes codes for a protein called Vpr, which has recently been shown to prevent activation of the mitotic cyclin-dependent kinase and thereby prevent infected cells from undergoing mitosis and proliferating. Vpr also plays an important role in another property of HIV-1 that is unusual for a retrovirus - its ability to enter the nucleus of a nondividing cell. Understanding the interactions between HIV-1 and the cell cycle should lead to new insights into both viral pathogenesis and basic cell biology.
Emerman
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Room C2-023, Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, Washington 98104, USA.
D002453:Cell Cycle / Q000235:genetics*; D002454:Cell Differentiation; D016336:Gene Products, vpr / Q000378:metabolism / Q000502:physiology*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D014779:Virus Replication / Q000502:physiology; D054325:vpr Gene Products, Human Immunodeficiency Virus
D016336:Gene Products, vpr; D054325:vpr Gene Products, Human Immunodeficiency Virus