The use of haemodialysis and 2,3 propanesulphonate (DMPS) to manage acute oral poisoning by lethal dose of arsenic trioxide.
The paper discusses a case of oral acute poisoning by dental paste containing arsenic trioxide. A 33-year-old woman ingested 1/3 of the dental paste package, which corresponds to 1850 mg pure arsenic trioxide. Acute gastroenteritis and oral mucosa burn developed within 3 hours since the poisoning. Considering the amount of the ingested poison, highly exceeding the lethal dose, haemodialysis was undertaken. During the treatment, DMPS (Unithiol) was administered, with the patient's consent. The patient recovered completely, with no complications or side-effects of the therapy.
Kruszewska
S
S
Clinic of Acute Poisoning, Nofer Institute of Occupational Medicine, Lodz, Poland.
Wiese
M
M
Kołaciński
Z
Z
Mielczarska
J
J
D000328:Adult; D020261:Arsenic Poisoning; D000077237:Arsenic Trioxide; D001152:Arsenicals; D002614:Chelating Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D010087:Oxides / Q000506:poisoning*; D011041:Poisoning / Q000628:therapy; D006435:Renal Dialysis; D014100:Toothpastes / Q000009:adverse effects*; D014494:Unithiol / Q000627:therapeutic use*
D001152:Arsenicals; D002614:Chelating Agents; D010087:Oxides; D014100:Toothpastes; D014494:Unithiol; D000077237:Arsenic Trioxide