title: The effect of long-term post-ischemic bifemelane hydrochloride treatment on cholinergic systems in the gerbil hippocampus.
abstract: Bifemelane hydrochloride (BF) is a modulator of various neurotransmitter systems. The effect of BF on the cholinergic system was studied in the gerbil hippocampus at 100 days after ischemic damage. Marked enhancement of AChE staining was noticed in the CA1 of saline-treated animals at 100 days after ischemia, while the post-ischemic enhancement of AChE staining intensity was milder in BF-treated animals. Muscarinic receptor density was markedly decreased in the CA1 subfield after ischemia. Interestingly, BF-treated animals showed higher muscarinic receptor binding in many brain areas, particularly in the dentate gyrus. These results indicate that BF modulates cholinergic neuronal plasticity in the ischemic hippocampus after long-term survival.
authors.affiliation: Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: Y L
authors.initials: YL
authors.lastname: Huang
authors.forename: H
authors.initials: H
authors.lastname: Onodera
authors.forename: A
authors.initials: A
authors.lastname: Takeda
authors.forename: Y
authors.initials: Y
authors.lastname: Itoyama
authors.forename: K
authors.initials: K
authors.lastname: Kogure
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D005260:Female; D005849:Gerbillinae; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D006651:Histocytochemistry; D002546:Ischemic Attack, Transient / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D018697:Nootropic Agents / Q000494:pharmacology*; D010275:Parasympathetic Nervous System / Q000187:drug effects* / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000378:metabolism; D013194:Staining and Labeling; D013997:Time Factors
chemical_list: D001559:Benzhydryl Compounds; D018697:Nootropic Agents; D011976:Receptors, Muscarinic; D000110:Acetylcholinesterase; C031906:bifemelane