title: Epidemiology of cryptococcosis in France: a 9-year survey (1985-1993). French Cryptococcosis Study Group.
abstract: We analyzed the data collected during a nationwide survey of cryptococcosis (1985-1993). We first checked the quality of the survey. The stability of its completeness (approximately 50%) and its representativity were assessed by the capture-recapture method after we cross-checked our data on cryptococcosis (as a presenting manifestation of AIDS) against those of the national registry of AIDS. Of the 1,057 cases of cryptococcosis (1,013 patients), 827 (86%) involved patients with AIDS. The increasing number of cases of human immunodeficiency virus (HIV)-related cryptococcosis over time paralleled the AIDS epidemic except for a higher male-to-female ratio. Malignancies (32%), organ transplantation (19%), and corticosteroid therapy (33%) were the main predisposing conditions in 163 patients without AIDS. Cryptococcal meningitis more frequently occurred in patients with AIDS than in HIV-negative patients (P < 10(-6)). Among the 413 isolates available for serotyping, 410 were Cryptococcus neoformans variety neoformans (including 20.5% of serotype D). Three isolates of the variety gattii (serotype B) were recovered from patients without AIDS.
authors.affiliation: Centre National de Référence des Mycoses et des Antifongiques, Institut Pasteur, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Dromer
authors.forename: S
authors.initials: S
authors.lastname: Mathoulin
authors.forename: B
authors.initials: B
authors.lastname: Dupont
authors.forename: A
authors.initials: A
authors.lastname: Laporte
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000453:epidemiology / Q000382:microbiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D002648:Child; D003453:Cryptococcosis / Q000150:complications / Q000453:epidemiology* / Q000382:microbiology; D003455:Cryptococcus neoformans / Q000145:classification / Q000302:isolation & purification; D003625:Data Collection; D005069:Evaluation Studies as Topic; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012703:Serotyping; D011795:Surveys and Questionnaires; D013997:Time Factors
chemical_list: D000935:Antifungal Agents