Time and dose dependency of radiation-induced changes in tumor microvascular characteristics using contrast-enhanced magnetic resonance imaging: impact on the delivery of chemotherapeutic agents.
Schmidt
H C
HC
Department of Radiology, University of California, San Francisco, USA.
Brasch
R C
RC
Roberts
T P
TP
Shames
D M
DM
van Dijke
C F
CF
Stiskal
M
M
Mann
J S
JS
Mühler
A
A
Demsar
F
F
D000230:Adenocarcinoma / Q000098:blood supply* / Q000532:radiotherapy; D000418:Albumins / Q000493:pharmacokinetics*; D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D002199:Capillary Permeability / Q000502:physiology* / Q000528:radiation effects; D002945:Cisplatin / Q000493:pharmacokinetics / Q000494:pharmacology*; D003287:Contrast Media / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D019786:Gadolinium DTPA; D008279:Magnetic Resonance Imaging; D008325:Mammary Neoplasms, Experimental / Q000098:blood supply* / Q000532:radiotherapy; D008833:Microcirculation / Q000503:physiopathology / Q000528:radiation effects; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D004369:Pentetic Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D051381:Rats; D011916:Rats, Inbred F344
D000418:Albumins; D000970:Antineoplastic Agents; D003287:Contrast Media; D009942:Organometallic Compounds; C058946:albumin-(gadolinium-DTPA); D004369:Pentetic Acid; D019786:Gadolinium DTPA; D002945:Cisplatin