title: Effect of temperature on the high-performance liquid chromatographic separation of the anti-HIV agents, didanosine and stavudine.
abstract: This paper examines the effect of temperature on the chromatographic separation characteristics of anti-HIV agents, didanosine and stavudine. As a result of lowering the column temperature, an improved resolution between didanosine and stavudine peaks is observed. Thus, lower temperatures may permit the simultaneous monitoring of didanosine and stavudine levels.
authors.affiliation: Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543, USA.
authors.forename: F A
authors.initials: FA
authors.lastname: Stancato
authors.forename: N R
authors.initials: NR
authors.lastname: Srinivas
authors.forename: C A
authors.initials: CA
authors.lastname: Knupp
mesh_terms: D000998:Antiviral Agents / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid / Q000379:methods* / Q000706:statistics & numerical data; D016049:Didanosine / Q000302:isolation & purification*; D006678:HIV / Q000187:drug effects*; D018119:Stavudine / Q000302:isolation & purification*; D013696:Temperature
chemical_list: D000998:Antiviral Agents; D018119:Stavudine; D016049:Didanosine