title: Interleukin-12: a pivotal regulator of cell-mediated immunity.
authors.affiliation: Department of Inflammation/Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110-1199, USA.
authors.forename: M K
authors.initials: MK
authors.lastname: Gately
authors.forename: M J
authors.initials: MJ
authors.lastname: Brunda
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism / Q000821:virology; D002461:Cell Line, Transformed; D003001:Cloning, Molecular; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005786:Gene Expression Regulation; D000882:Haplorhini; D006410:Hematopoiesis / Q000187:drug effects; D004854:Herpesvirus 4, Human; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology*; D007073:Immunoglobulin E / Q000096:biosynthesis; D007239:Infections / Q000628:therapy; D018664:Interleukin-12 / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use / Q000633:toxicity; D008213:Lymphocyte Activation / Q000187:drug effects; D016131:Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology; D051379:Mice; D009374:Neoplasms, Experimental / Q000628:therapy; D018123:Receptors, Interleukin / Q000737:chemistry / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D053707:Receptors, Interleukin-12; D015398:Signal Transduction / Q000502:physiology; D014162:Transfection; D014612:Vaccines / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D018123:Receptors, Interleukin; D053707:Receptors, Interleukin-12; D014612:Vaccines; D018664:Interleukin-12; D007073:Immunoglobulin E