[The differentiation of the antigens making up the circulating immune complexes].
A simple method for the detection and analysis of circulating immune complexes (CIC) in specimens of biological fluids is proposed. The method was approved in the examination of patients with chronic infections caused by mycoplasmas and Streptococcus pyogenes L-forms. The method made it possible to diagnose infectious diseases accompanied by the formation of immune complexes and to study the dynamics of the processes of the accumulation and elimination of CIC in the course of the disease. Thus, the detection rate of specific antigens (Ag) incorporated into CIC in patients with mycoplasmal pneumonia exceeded 90 %. In children aged up to 1 year this rate decreased to 40 %. The diagnostic value of the determination of specific Ag incorporated into CIC was shown in streptococcal infections caused by S.pyogenes L-forms, viz. in frequently relapsing erysipelas, as well as in subacute rheumatism and in infectious allergic myocarditis.
Gorina
L G
LG
Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia.
Vul'fovich
Iu V
IuV
D000293:Adolescent; D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood*; D000942:Antigens, Bacterial / Q000097:blood*; D001170:Arthritis, Infectious / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D002850:Chromatography, Gel; D000939:Epitopes / Q000097:blood; D004886:Erysipelas / Q000276:immunology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009177:Mycoplasma pneumoniae / Q000276:immunology; D009205:Myocarditis / Q000276:immunology; D011019:Pneumonia, Mycoplasma / Q000276:immunology; D012008:Recurrence; D012216:Rheumatic Diseases / Q000276:immunology; D013297:Streptococcus pyogenes / Q000276:immunology
D000936:Antigen-Antibody Complex; D000942:Antigens, Bacterial; D000939:Epitopes