title: Interleukin-8 immunoreactivity in malignant tumours of the skin.
abstract: In the past, interleukin-8 (IL-8) could be demonstrated within keratinocytes in normal epidermis and inflammatory skin diseases, like psoriasis and eczema. Using monoclonal antibodies, the distribution of IL-8 immunoreactivity was inversely related to the density of inflammatory infiltrate. Other in vitro observations indicated IL-8 to be a growth factor for keratinocytes. These results prompted an immunohistochemical examination of IL-8 immunoreactivity in malignant and semimalignant epithelial tumours of human skin. Whereas IL-8 could not be detected within the transformed cells of epithelial tumours or melanoma, some tumour cells within well differentiated squamous cell carcinoma and Bowen's disease showed IL-8 immunoreactivity. Thus, loss of IL-8 immunoreactivity can be a sign of malignant transformation. This indicates an important role in growth regulation as well as terminal differentiation of human keratinocytes.
authors.affiliation: Department of Dermatology, University of Kiel, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Bornscheuer
authors.forename: J M
authors.initials: JM
authors.lastname: Schröder
authors.forename: E
authors.initials: E
authors.lastname: Christophers
authors.forename: M
authors.initials: M
authors.lastname: Sticherling
mesh_terms: D001913:Bowen's Disease / Q000378:metabolism; D002280:Basal Cell Carcinoma / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D016209:Interleukin-8 / Q000032:analysis*; D015603:Keratinocytes / Q000378:metabolism; D008545:Melanoma / Q000378:metabolism; D012867:Skin / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism*
chemical_list: D016209:Interleukin-8