title: Current role and future perspectives for radiofrequency catheter ablation of postmyocardial infarction ventricular tachycardia.
abstract: The most common substrate for ventricular tachycardia (VT) is a postmyocardial infarction (MI) scar. Radiofrequency catheter ablation (RFCA) in post-MI VT faces clinical, electrophysiologic, anatomic, and methodologic difficulties not found in many other human tachycardias. The pathophysiologic understanding of post-MI VT is incomplete; this influences the process of selecting RFCA target sites, which is time consuming, demands catheter stability, and has low sensitivity and predictive value for VT interruption by RF current. Improving and simplifying the methodology of RFCA in post-MI VT is badly needed. We review the pathophysiology of post-MI VT from the data reported on endocardial, epicardial, and intramural ventricular mapping obtained either intraoperatively or in a Langendorff perfused set-up in hearts from transplanted patients. From these studies we conclude that (1) some post-MI VT cases are not amenable to RFCA (reentry around the scar, VT having a subepicardial or deep intramural substrate, or a wide, extensive, subendocardial intrascar area of slow conduction); and (2) searching for the endocardial exit is advantageous for selecting the RFCA targets. We also comment on a new self-reference mapping catheter that allows the recording of high gain, noise-free, unfiltered and filtered unipolar signals as well as unipolar pacing. Among the unresolved issues in these patients is the meaning of fast nonclinical VT induced after successful RFCA of the clinical VT, which may explain why a substantial number of these patients still receive an implantable cardioverter-defibrillator.
authors.affiliation: Servicio de Cardiología, Fundación Jiménez Díaz, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Farré
authors.forename: J M
authors.initials: JM
authors.lastname: Rubio
authors.forename: F
authors.initials: F
authors.lastname: Navarro
authors.forename: L
authors.initials: L
authors.lastname: Sanziani
authors.forename: D
authors.initials: D
authors.lastname: Rivas
authors.forename: J
authors.initials: J
authors.lastname: Romero
mesh_terms: D017115:Catheter Ablation; D004562:Electrocardiography; D006801:Humans; D009203:Myocardial Infarction / Q000150:complications*; D017180:Tachycardia, Ventricular / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*