title: Desulfation of tyrosine-O-sulfated peptides by some eukaryotic sulfatases.
abstract: Three mammalian and eight non-mammalian arylsulfatases were investigated for their activities toward tyrosine-O-sulfate (TyrS) in peptides. None of the mammalian arylsulfatases exhibited detectable activities toward TyrS-containing peptides. Of the non-mammalian arylsulfatases tested, Types VII, VIII, and H-1, 2, and 5 displayed strong activity on endo-TyrS residues. The prokaryotic sulfatase, Type VI, was active only on free TyrS and N-terminal TyrS of Leu-enkephalin. All the sulfatases were active on p-nitrophenyl sulfate and p-nitrocatechol sulfate.
authors.affiliation: Department of Biological Resource Sciences, Miyazaki University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Suiko
authors.forename: T
authors.initials: T
authors.lastname: Tojo
authors.forename: P H
authors.initials: PH
authors.lastname: Fernando
authors.forename: Y
authors.initials: Y
authors.lastname: Sakakibara
authors.forename: J
authors.initials: J
authors.lastname: Kawano
authors.forename: M C
authors.initials: MC
authors.lastname: Liu
mesh_terms: D010455:Peptides / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000235:genetics; D013429:Sulfatases / Q000737:chemistry*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D010455:Peptides; C005662:tyrosine O-sulfate; D014443:Tyrosine; D013429:Sulfatases