Could an aminoacridine interfere with the cellular mechanisms involved in the process of human immunodeficiency virus infection?
Immune activation and synthesis of nucleic acids participate in the course of infection by human immunodeficiency virus. Aminoacridines, formally used as antiparasitic drugs, but almost abandoned nowadays for therapeutic use, are strong deoxyribonucleic acid chemoprotectors and lysosome stabilizers. Theoretically, these actions within the cell and other peculiar pharmacological characteristics of aminoacridines, particularly quinacrine, could pose barriers to human immunodeficiency virus infection and replication.
Sotelo
J
J
National Institute of Neurology and Neurosurgery of Mexico, Mexico City, Mexico. jsotelo@servidor.unam.mx
D000585:Aminacrine / Q000494:pharmacology / Q000627:therapeutic use*; D006678:HIV / Q000187:drug effects / Q000502:physiology*; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D007364:Intercalating Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008213:Lymphocyte Activation / Q000187:drug effects; D008962:Models, Theoretical; D011796:Quinacrine / Q000627:therapeutic use; D014779:Virus Replication / Q000187:drug effects*
D007364:Intercalating Agents; D000585:Aminacrine; D011796:Quinacrine