title: T-cell costimulation: T cells themselves call the shots.
abstract: The CD40L molecule expressed by CD4+ regulatory T lymphocytes is known to deliver signals that activate B cells and macrophages. It now appears that CD40L regulates T cells themselves, during both their development and their participation in adaptive immune responses.
authors.affiliation: Montreal Neurological Institute, McGill University, Quebec, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Owens
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D019013:CD40 Antigens / Q000276:immunology; D023201:CD40 Ligand; D008562:Membrane Glycoproteins / Q000276:immunology*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
chemical_list: D019013:CD40 Antigens; D008562:Membrane Glycoproteins; D023201:CD40 Ligand