title: Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q.
abstract: Metabotropic glutamate receptors (GRMs) are neurotransmitter receptors that respond to glutamate stimulations by activating GTP-binding proteins and modulating second-messenger cascades. Eight related GRMs have been identified to date. In this study, we have mapped GRM3 and GRM8 to human chromosome 7q21.1-q21.2 and 7q31.3-q32.1, respectively, using somatic cell hybrid and fluorescence in situ hybridization analysis. A yeast artificial chromosome contig was constructed surrounding the genes, allowing their location to be integrated into the genetic and physical map of chromosome 7.
authors.affiliation: Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada.
authors.forename: S W
authors.initials: SW
authors.lastname: Scherer
authors.forename: R M
authors.initials: RM
authors.lastname: Duvoisin
authors.forename: R
authors.initials: R
authors.lastname: Kuhn
authors.forename: H H
authors.initials: HH
authors.lastname: Heng
authors.forename: E
authors.initials: E
authors.lastname: Belloni
authors.forename: L C
authors.initials: LC
authors.lastname: Tsui
mesh_terms: D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D004247:DNA / Q000235:genetics; D015894:Genome, Human; D006801:Humans; D008969:Molecular Sequence Data; D051381:Rats; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics*
chemical_list: D018094:Receptors, Metabotropic Glutamate; D004247:DNA