Effect of six months of growth hormone therapy, followed by treatment withdrawal in short children with normal quantitative indexes of growth hormone secretion.
Eight short patients with normal 24-hour integrated concentration of growth hormone by continuous withdrawal (IC-GH) received 6 months of GH therapy, followed by 6 months off. GH therapy increased growth rate (+2.9 cm/yr), repeated IC-GH (sixfold), and IGF-1 concentration (twofold). Posttreatment growth reverted to the pretreatment rate. Thus increased growth rate and IGF-1 concentration is associated with supraphysiologic IC-GH after injection.
Chalew
S A
SA
Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201, USA.
Phillip
M
M
Kowarski
A A
AA
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006128:Growth; D006130:Growth Disorders / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D013006:Growth Hormone / Q000008:administration & dosage* / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008297:Male
D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone