[Interrelationship of reflux bile acid concentration and the gastric mucosal change with reference to the pathophysiologic significance of taurine conjugated deoxycholic acid and chenodeoxycholic acid].
Since chronic gastritis is adversely affected by reflux bile acids, we are interested in which of these bile acids cause the most damage to the gastric mucosa as ulcerogenic factors in the stomach. We examined 34 patients suffering from the peptic ulcers, and have assumed that taurine conjugated deoxycholic acid (TDC) and chenodeoxycholic acid (TCDC) may act as the mst ulcerogenic factors. Moreover TCDC was suggested to be associated with the cystic dilatation of the gastric gland. It was also suggested that TDC is involved in the increased frequency of intestinal metaplasia as a factor backgrounding cancer.
Toyoshima
A
A
Center for Digestive Diseases, Nippon Medical School Second Hospital, Kanagawa-ken, Japan.
Ito
M
M
Tsunoda
S
S
Umakoshi
M
M
D000328:Adult; D000368:Aged; D001284:Atrophy; D001655:Bile Reflux / Q000150:complications* / Q000378:metabolism; D002635:Chenodeoxycholic Acid / Q000009:adverse effects* / Q000378:metabolism; D004108:Dilatation, Pathologic; D005753:Gastric Mucosa / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D013276:Stomach Ulcer / Q000209:etiology* / Q000473:pathology*; D013657:Taurodeoxycholic Acid / Q000009:adverse effects* / Q000378:metabolism
D002635:Chenodeoxycholic Acid; D013657:Taurodeoxycholic Acid