Putting a lid on protein folding: structure and function of the co-chaperonin, GroES.
The co-chaperonin GroES is an essential partner in protein folding mediated by the chaperonin, GroEL. Two recent crystal structures of GroES provide a structural basis to understand how GroES forms the lid on the folding-active cis ternary complex, and how the GroEL-GroES complex enhances folding.
Fenton
W A
WA
Department of Genetics, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
Weissman
J S
JS
Horwich
A L
AL
D018835:Chaperonin 10 / Q000737:chemistry* / Q000378:metabolism*; D011485:Protein Binding; D011487:Protein Conformation; D017510:Protein Folding; D013329:Structure-Activity Relationship
D018835:Chaperonin 10