title: Subchronic use of the St. Jude centrifugal pump as a mechanical assist device in calves.
abstract: The purpose of this experiment was to study the effects of the St. Jude Lifestream centrifugal pump on hemodynamic and hematologic parameters and the incidence of postmortem findings in a subchronic ex vivo left ventricular assist animal model. Five calves were implanted with the pump as a left ventricular assist device (left atrial to thoracic aorta bypass) and studied for 96 h of continuous pumping under identical conditions. Heparin (100 IU/kg) was administered only in the initial saline pump prime. Throughout the protocol, mean arterial and central venous pressures averaged 102.1 +/- 4.6 and 3.4 +/- 2.2 mm Hg, respectively. Pump flow was 47.8 +/- 8.4 ml/kg/min at a mean pump speed of 1,676.3 +/- 106.1 rpm. No clinical abnormalities or mechanical malfunctions attributable to the pump were detected during the 96 h of continuous pumping for each calf. Mean plasma-free hemoglobin after 96 h was 3.9 +/- 3.7 mumol/L (p = 0.337 compared to baseline). At post mortem, renal infarctions were detected in 1 calf. No other pump-associated lesions were detected in any of the other calves. We have concluded that the St. Jude Lifestream centrifugal pump functions reliably during 96 h of continuous left heart bypass in a calf model.
authors.affiliation: Department of Surgery, School of Medicine, University of Missouri, Columbia, USA.
authors.forename: J
authors.initials: J
authors.lastname: Curtis
authors.forename: C
authors.initials: C
authors.lastname: Wagner-Mann
authors.forename: F
authors.initials: F
authors.lastname: Mann
authors.forename: T
authors.initials: T
authors.lastname: Demmy
authors.forename: J
authors.initials: J
authors.lastname: Walls
authors.forename: J
authors.initials: J
authors.lastname: Turk
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology*; D002417:Cattle; D002498:Centrifugation; D018611:Heart Bypass, Left; D006353:Heart-Assist Devices / Q000592:standards*; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D010976:Platelet Count; D011183:Postoperative Complications / Q000517:prevention & control
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D006493:Heparin