Transferable cefoxitin resistance in enterobacteria from Greek hospitals and characterization of a plasmid-mediated group 1 beta-lactamase (LAT-2).
Cefoxitin resistance in Klebsiella pneumoniae from Escherichia coli strains isolated in Greek hospitals was found to be due to the acquisition of similar plasmids coding for group 1 beta-lactamases. The plasmids were not self-transferable but were mobilized by conjugative plasmids. These elements have also been spread to Enterobacter aerogenes. The most common enzyme was a Citrobacter freundii-derived cephalosporinase (LAT-2) which differed from LAT-1 by three amino acids.
Gazouli
M
M
Department of Bacteriology, Hellenic Pasteur Institute, Athens, Greece.
Tzouvelekis
L S
LS
Prinarakis
E
E
Miriagou
V
V
Tzelepi
E
E
D000595:Amino Acid Sequence; D001483:Base Sequence; D002440:Cefoxitin / Q000494:pharmacology*; D002513:Cephamycins / Q000494:pharmacology*; D016971:Citrobacter freundii / Q000187:drug effects / Q000201:enzymology / Q000235:genetics; D003227:Conjugation, Genetic; D003428:Cross Infection / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D004754:Enterobacter / Q000187:drug effects / Q000201:enzymology / Q000235:genetics; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000235:genetics; D006115:Greece; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010405:Penicillinase / Q000235:genetics*; D010957:Plasmids
D002513:Cephamycins; D002440:Cefoxitin; D010405:Penicillinase