The effects of low-, medium-, and high-fat diets on 2-deoxy-D-glucose- and mercaptoacetate-induced feeding.
The present study examined the feeding responses stimulated by low suprathreshold and optimal doses of 2-DG and MA in three groups of rats maintained and tested on low (4.3%), medium (13.5%), or high (66.4%) fat diets. Results show that diet alters the response to 2-DG and MA. Rats on the low-fat diet significantly increased food intake after both the low and high doses of 2-DG. Rats on the medium- and high-fat diet significantly increased food intake after both the low and high doses of 2-DG. Rats on the medium- and high-fat diets significantly increased food intake only after the high dose of 2-DG. After administration of the low and high doses of MA, rats on the high-fat diet ate significantly more. However, rats on the low- and medium-fat diets significantly increased food intake only after the high dose of MA. These results suggest that diet-induced dependence of rats on fat or carbohydrate metabolism alters the sensitivity of systems controlling food intake in response to deficits in the availability of these specific metabolic fuels.
Singer-Koegler
L K
LK
Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman 99164-6520, USA.
Magluyan
P
P
Ritter
S
S
D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology*; D001066:Appetite / Q000187:drug effects*; D001786:Blood Glucose / Q000378:metabolism; D003847:Deoxyglucose / Q000494:pharmacology*; D004041:Dietary Fats / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D005227:Fatty Acids / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013864:Thioglycolates / Q000494:pharmacology*
D000963:Antimetabolites; D001786:Blood Glucose; D004041:Dietary Fats; D005227:Fatty Acids; D013864:Thioglycolates; C017487:2-mercaptoacetate; D003847:Deoxyglucose