title: The comparative in vitro activity of clinafloxacin and other antimicrobials against vancomycin-susceptible and vancomycin-resistant enterococci.
abstract: The susceptibilities of 50 unique vancomycin-susceptible (n = 15) and vancomycin-resistant (n = 35) enterococci to 6 antimicrobials were compared. Teicoplanin was consistently the most active agent for all strains. Ampicillin and imipenem were active primarily for vancomycin-sensitive Enterococcus faecalis. Clinafloxacin and ciprofloxacin showed poorer activity compared to prior studies, suggesting that the emergence of quinolone resistance is now occurring in enterococci.
authors.affiliation: Department of Pharmacy, Michael Reese Hospital and Medical Center, Chicago, Illinois, USA.
authors.forename: G S
authors.initials: GS
authors.lastname: Itokazu
authors.forename: C
authors.initials: C
authors.lastname: Nathan
authors.forename: R
authors.initials: R
authors.lastname: Hariharan
authors.forename: J R
authors.initials: JR
authors.lastname: Kostman
authors.forename: S A
authors.initials: SA
authors.lastname: Kabins
authors.forename: R A
authors.initials: RA
authors.lastname: Weinstein
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D016983:Enterococcus / Q000187:drug effects*; D013293:Enterococcus faecalis / Q000187:drug effects; D016984:Enterococcus faecium / Q000187:drug effects; D024841:Fluoroquinolones; D015378:Imipenem / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology; D015363:Quinolones / Q000494:pharmacology*; D017334:Teicoplanin / Q000494:pharmacology; D013845:Thienamycins / Q000494:pharmacology; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D010406:Penicillins; D015363:Quinolones; D013845:Thienamycins; D002939:Ciprofloxacin; D017334:Teicoplanin; D014640:Vancomycin; D015378:Imipenem; D000667:Ampicillin; C057477:clinafloxacin