title: Sequence databases and homology searching using the World Wide Web.
abstract: RNA, DNA and protein sequence data produced in laboratories around the world may be freely accessed by other scientists using the Internet. Originally, these sequence databases were compiled from published literature, but now researchers may deposit sequence data directly, using the World Wide Web. Almost 50,000 protein sequences and over 600,000 nucleotide sequences are available, forming a significant scientific resource. By comparing novel sequence data with sequence entries and structural data showing significant homology, it is possible to predict the function and three-dimensional structure of novel proteins.
authors.affiliation: Department of Medicine, St. Mary's Hospital Medical School, Imperial College, London, UK m.paterson@sm.ic.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Paterson
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D003195:Computer Communication Networks; D004247:DNA / Q000737:chemistry; D016208:Databases, Factual; D009862:Online Systems; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry; D012313:RNA / Q000737:chemistry; D017386:Sequence Homology, Amino Acid; D012984:Software
chemical_list: D011506:Proteins; D012313:RNA; D004247:DNA