title: Lactarane type sesquiterpenoids as inhibitors of leukotriene biosynthesis and other, new metabolites from submerged cultures of Lentinellus cochleatus (Pers. ex Fr.) Karst.
abstract: Three known sesquiterpenoids of the lactarane and secolactarane type, deoxylactarorufin A (1), blennin A (2) and blennin C (3), have been obtained from cultures of Lentinellus cochleatus (Basidiomycetes) together with the new metabolites (Z)-2-chloro-3-(4-methoxyphenyl)-2-propen-1-ol (4) and lentinellone (5), a protoilludane derivative. The structures were determined by spectroscopic investigations. 1, 2 and 3 are potent inhibitors of leukotriene biosynthesis in rat basophilic leukemia (RBL-1) cells and human peripheral blood leukocytes (PBL).
authors.affiliation: LB Biotechnologie der Universität, Kaiserslautern, Bundesrepublik Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Wunder
authors.forename: T
authors.initials: T
authors.lastname: Anke
authors.forename: D
authors.initials: D
authors.lastname: Klostermeyer
authors.forename: W
authors.initials: W
authors.lastname: Steglich
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001487:Basidiomycota / Q000254:growth & development / Q000378:metabolism; D002460:Cell Line; D002855:Chromatography, Thin Layer / Q000379:methods; D003470:Culture Media; D015232:Dinoprostone / Q000096:biosynthesis / Q000097:blood; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D006801:Humans; D015471:Leukemia, Basophilic, Acute; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism*; D020024:Leukotriene Antagonists; D007975:Leukotriene B4 / Q000096:biosynthesis / Q000097:blood; D017997:Leukotriene C4 / Q000096:biosynthesis / Q000097:blood; D015289:Leukotrienes / Q000096:biosynthesis*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D051381:Rats; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003470:Culture Media; D020024:Leukotriene Antagonists; D015289:Leukotrienes; D012717:Sesquiterpenes; D007975:Leukotriene B4; D017997:Leukotriene C4; D015232:Dinoprostone