The origin of the antiseptic-resistance gene ebr in Staphylococcus aureus.
The antiseptic-resistance gene ebr was detected not only in resistant strains of Staphylococcus aureus but also in sensitive strains of S. aureus, in coagulase-negative staphylococcal strains and in enterococcal strains by means of the polymerase chain reaction. The nucleotide sequence of the amplified DNA fragment of the ebr gene from a sensitive strain and that of the previously reported ebr gene were identical. It seems likely that antiseptic-resistant cells result from an increase in the copy number of a gene whose normal function is to remove toxic substances from normal sensitive cells of staphylococci and enterococci.
Sasatsu
M
M
Department of Microbiology, Showa College of Pharmaceutical Sciences, Machida, Tokyo, Japan.
Shirai
Y
Y
Hase
M
M
Noguchi
N
N
Kono
M
M
Behr
H
H
Freney
J
J
Arai
T
T
D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D017920:Antiporters; D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D004269:DNA, Bacterial / Q000737:chemistry; D004352:Drug Resistance, Microbial; D029968:Escherichia coli Proteins; D005798:Genes, Bacterial; D008565:Membrane Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D013211:Staphylococcus aureus / Q000187:drug effects / Q000235:genetics*
D000891:Anti-Infective Agents, Local; D017920:Antiporters; D001426:Bacterial Proteins; D002352:Carrier Proteins; D004269:DNA, Bacterial; D029968:Escherichia coli Proteins; D008565:Membrane Proteins; C075436:EmrE protein, E coli