19p+ marker chromosome correlates with relapse in malignant fibrous histiocytoma.
In this study, we examined the relationship of 19p13 aberrations, usually leading to addition of unknown material (19p+), and ring chromosomes to clinical outcome in patients with malignant fibrous histiocytoma (MFH). Analysis of 69 MFHs revealed 19 tumors with 19p+ and 24 tumors with ring chromosomes. After a median follow-up period of 36 months, 24 patients developed metastases, and 27 patients developed local recurrences. Ten patients had both local recurrences and metastases. Local recurrence was more common in association with 19p+ than without. Metastasis was more common with 19p+ tumors in high-risk patients (tumor size > 5 cm and grade III-IV; n = 48) than those without 19p+. There was a trend suggesting fewer relapses after tumors with ring chromosomes. 19p+ may be an independent marker of unfavorable outcome in MFH.
Choong
P F
PF
Department of Orthopedics, University Hospital, Lund, Sweden.
Mandahl
N
N
Mertens
F
F
Willén
H
H
Alvegård
T
T
Kreicbergs
A
A
Mitelman
F
F
Rydholm
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D002888:Chromosomes, Human, Pair 19; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000473:pathology; D018219:Histiocytoma, Benign Fibrous / Q000235:genetics* / Q000473:pathology / Q000556:secondary; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012186:Retroperitoneal Neoplasms / Q000235:genetics / Q000473:pathology; D012303:Ring Chromosomes