Anti-pseudomonal activity of collagen sponge with liposomal polymyxin B.
An antibiotic delivery system has been developed using collagen sponge with liposome-encapsulated polymyxin B. Superficial, non-lethal infection was produced in mice by injecting Pseudomonas aeruginosa into the skin windows. Wounds were dressed with collagen sponge containing liposomal polymyxin B or containing empty liposomes (with PBS) as a control. Single dose of topically applied collagen sponge with encapsulated polymyxin B decreased bacterial cell number as compared to the control. Finally, after 8 days of experiment, the number of bacterial colonies dropped below 10(4) per biopsy. Presented polymyxin B delivery system offers potential clinical advantages.
Trafny
E A
EA
Department of Microbiology, Military Institute of Hygiene and Epidemiology, Warszawa, Poland.
Grzybowski
J
J
Olszowska-Golec
M
M
Antos
M
M
Struzyna
J
J
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003094:Collagen; D004337:Drug Carriers; D008081:Liposomes; D051379:Mice; D011112:Polymyxin B / Q000494:pharmacology*; D011549:Pseudomonas / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D008081:Liposomes; D003094:Collagen; D011112:Polymyxin B