Propafenone pharmacokinetics and pharmacodynamics in patients with sustained ventricular tachycardia.
The myocardium accumulation and pharmacodynamics of propafenone were evaluated during intravenous infusion in 6 patients undergoing electrophysiologic study for evaluation of ventricular tachycardia. The myocardial accumulation of propafenone was delayed and resulted in nonlinear arterial concentration-effect relations.
Gillis
A M
AM
Division of Cardiology, Foothills Hospital, Calgary, Alberta, Canada.
Wyse
D G
DG
Mitchell
L B
LB
Duff
H J
HJ
D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D011405:Propafenone / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D017180:Tachycardia, Ventricular / Q000097:blood*
D000889:Anti-Arrhythmia Agents; D011405:Propafenone