title: Lack of correlation between the molecular size and the efficacy of lanthanides for potentiating GABAA currents in rat septal cholinergic neurons in culture.
abstract: Actions of lanthanides were examined on GABAA receptor-activated responses in rat septal neurons in culture by using the whole-cell voltage-clamp technique. GABA (10 microM) currents were enhanced by these ions at 100 microM with an efficacy sequence of Pr3+ (1.11) > or = Lu3+ (1.07) > or = Gd3+ (1.02) > or = Er3+ (1.01) > or = La3+ (1: 40% increase) > or = Ce3+ (0.980) > or = Nd3+ (0.932) > or = Yb3+ (0.913) > or = Tb3+ (0.912), indicating the lack of correlation between the potentiating efficacy and ionic size of lanthanides.
authors.affiliation: Department of Physiology, Saga Medical School, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Kumamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Murata
mesh_terms: D000818:Animals; D002478:Cells, Cultured / Q000187:drug effects; D002799:Cholinergic Fibers / Q000187:drug effects*; D008674:Metals, Rare Earth / Q000494:pharmacology*; D008970:Molecular Weight; D018408:Patch-Clamp Techniques; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects*; D012686:Septal Nuclei / Q000187:drug effects*
chemical_list: D008674:Metals, Rare Earth; D011963:Receptors, GABA-A