Chemical and biological approaches to glycoprotein synthesis.
Protein glycosylation is a common posttranslational modification that produces glycoproteins that are highly complex in terms of both their structure and in their function. Systematic structure-function studies of such glycoproteins require synthetic methods that can produce homogeneous glycoproteins with defined oligosaccharide sidechains.
Bill
R M
RM
Department of Chemistry, The University of Michigan, Ann Arbor, MI 48109-1055, USA.
Flitsch
S L
SL
D006023:Glycoproteins / Q000096:biosynthesis* / Q000138:chemical synthesis / Q000378:metabolism; D006031:Glycosylation; D009844:Oligosaccharides / Q000378:metabolism*
D006023:Glycoproteins; D009844:Oligosaccharides