D-amphetamine challenge effects on Wisconsin Card Sort Test. Performance in schizotypal personality disorder.
The authors assessed the effects on Wisconsin Card Sort (WCST) performance and psychiatric symptoms of 30 mg d-amphetamine, a dopamine and norepinephrine agonist, vs placebo in nine patients with schizotypal personality disorder (SPD). Patients, particularly those who made more perseverative errors, demonstrated amphetamine-associated improvement on WCST performance. The data in this preliminary study suggest that some of the cognitive dysfunction present in SPD may improve with amphetamine challenge.
Siegel
B V
BV
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.
Trestman
R L
RL
O'Flaithbheartaigh
S
S
Mitropoulou
V
V
Amin
F
F
Kirrane
R
R
Silverman
J
J
Schmeidler
J
J
Keefe
R S
RS
Siever
L J
LJ
D000328:Adult; D000368:Aged; D001143:Arousal / Q000502:physiology; D001288:Attention / Q000502:physiology; D003072:Cognition Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D003913:Dextroamphetamine; D004298:Dopamine / Q000502:physiology; D015259:Dopamine Agents; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009638:Norepinephrine / Q000502:physiology; D011340:Problem Solving / Q000502:physiology; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology; D012569:Schizotypal Personality Disorder / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology
D015259:Dopamine Agents; D003913:Dextroamphetamine; D004298:Dopamine; D009638:Norepinephrine