Examination of the role of nitric oxide synthase and renal kallikrein as candidate genes for essential hypertension.
1. Nitric oxide synthase and renal kallikrein are both involved in blood pressure regulation. Genes for these enzymes may, therefore, be considered candidates for hypertension pathogenesis. 2. In the present study, genotypes for nitric oxide synthase and renal kallikrein microsatellite markers were determined in a cross-sectional association analysis of hypertensive patients and normotensive control subjects. 3. Results from this study did not indicate an association of either of the candidate gene polymorphisms with essential hypertension. Hence, findings for this study do not support a role for these genes in human hypertension.
Friend
L R
LR
Molecular Genetics Laboratory, School of Health Science, NHS Faculty, Griffith University, Gold Coast, Queensland, Australia.
Morris
B J
BJ
Gaffney
P T
PT
Griffiths
L R
LR
D000483:Alleles; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000201:enzymology* / Q000235:genetics*; D007610:Kallikreins / Q000235:genetics* / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology*; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D019001:Nitric Oxide Synthase / Q000235:genetics* / Q000378:metabolism*; D011110:Polymorphism, Genetic
D019001:Nitric Oxide Synthase; D007610:Kallikreins