Comparison of the satiating effect of the CCKA receptor agonist A71378 with CCK-8S.
The satiating effect of the selective cholecystokininA (CCKA) receptor agonist A71378 and the mixed A and B receptor agonist CCK-8S were compared in 24-h food-deprived rats. After systemic application of 1.6, 8.0, and 40 micrograms/kg A71378 or CCK-8S, respectively, food intake was measured for 24 h. During the first hour A71378 and CCK-8S decreased food intake similarly. Two and 4 h after treatment, the satiating effect of A71378 continued. In contrast, 2 h after administration of CCK-8S a slight effect was observed at the highest dose (40 micrograms/kg), which totally disappeared after 4 h. In summary, the effect of A71378 on food intake is longer lasting compared to CCK-8S.
Voits
M
M
Institute of Pharmacology and Toxicology, Charité, Medical Faculty of the Humboldt University, Berlin, Germany.
Voigt
J P
JP
Boomgaarden
M
M
Henklein
P
P
Fink
H
H
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011949:Receptors, Cholecystokinin / Q000819:agonists*; D012527:Satiation / Q000187:drug effects*; D012844:Sincalide / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors
C090019:8-sulfocholecystokinin octapeptide; D009842:Oligopeptides; D011949:Receptors, Cholecystokinin; C063897:A 71378; D012844:Sincalide