Daily hypocaloric feeding entrains circadian rhythms of wheel-running and body temperature in rats kept in constant darkness.
Since high levels of physical activity are known to interact with the circadian system, we tested whether hyperactivity induced by hypocaloric feeding may facilitate the synchronizing effect of periodic feeding in rats in constant darkness. Wheel-running (WRR) and body temperature (BTR) rhythms were analyzed in rats fed daily 50% of ad libitum food intake. In addition to a feeding-associated component (FAC) expressed for both rhythms, WRR and BTR were phase-shifted towards the feeding time by 12.1 +/- 0.4 and 12.4 +/- 0.4 h, respectively. BTR and FAC of temperature merged into a single cosine-wave food-entrained rhythm (FER) of temperature. Similarly, WRR and FAC of activity merged into a unimodal FER of wheel-running. This indicates that daily hypocaloric feeding may synchronize circadian rhythms in rats.
Challet
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E
Neurobiologie des Fonctions Rythmiques et Saisonnières, CNRS-URA 1332, Université Louis Pasteur, Strasbourg, France.
Malan
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A
Pévet
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P
D000818:Animals; D001831:Body Temperature / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D003624:Darkness; D002149:Energy Intake / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012044:Regression Analysis