title: [Assessment of tobacco impact on penile vascularization with echo-Doppler and intracavernous injection].
abstract: The negative role of smoking on circulation is widespread knowledge and it has been rated as a vascular risk factor. This paper evaluates the influence of smoking on the arterial supply to the erectile tissue, establishing the flow speed parameters in cavernous arteries with eco-doppler both at rest and after intracavernous PgE1 injection. Four groups were studied: non-smokers, without arterial disease and with arterial disease of non-smoking etiology; smokers with vascular disease, and another group where smoking was the only verified etiological factor. No significant differences were detected in flow speed parameters at rest among smokers and non smokers both in individuals with preserved erectile potency or with erectile dysfunction. Following drug therapy, impotent smokers showed the worse erectile response. With regard to flow speed parameters, although the differences were not significant, it can be seen that smokers, whether potent or not, show less differential speed, flow time, and acceleration, exhibiting a certain degree of arterial rigidity. That flow speed parameters, in cases with erectile dysfunction, can be superposed in individuals with arterial-origin impotence and those where smoking is the sole risk factor, indicates that this is a factor which causes erectile dysfunction due to vascular damage, as severe as any other caused by other factors such as arteriosclerosis, diabetes, or hypertension.
authors.affiliation: Servicio de Urología, Hospital Universitario La Fe, Valencia.
authors.forename: J F
authors.initials: JF
authors.lastname: Vidal Moreno
authors.forename: B
authors.initials: B
authors.lastname: Moreno Pardo
authors.forename: J F
authors.initials: JF
authors.lastname: Jiménez Cruz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000527:Alprostadil / Q000008:administration & dosage; D000704:Analysis of Variance; D001783:Blood Flow Velocity; D006801:Humans; D018783:Impotence, Vasculogenic / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D007267:Injections; D008297:Male; D008875:Middle Aged; D010413:Penis / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000187:drug effects; D012907:Smoking / Q000009:adverse effects*; D018608:Ultrasonography, Doppler
chemical_list: D000527:Alprostadil