The use of hydroxychloroquine in lupus pregnancy: the British experience.
Hydroxychloroquine (HCQ) is a valuable and possibly underused agent in treating mild lupus. Whether this drug should be discontinued in pregnancy is still controversial. We studied the full obstetric histories of 33 women with lupus who had taken HCQ at some point during pregnancy. HCQ was not, apparently, teratogenic and we believe that continuation of this drug is probably safe in lupus pregnancies.
Khamashta
M A
MA
Lupus Research Unit, Rayne Institute, St. Thomas' Hospital, London.
Buchanan
N M
NM
Hughes
G R
GR
D000328:Adult; D000962:Antimalarials / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000009:adverse effects / Q000627:therapeutic use*; D007231:Infant, Newborn; D008179:Lupus Erythematosus, Discoid / Q000150:complications* / Q000188:drug therapy*; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011256:Pregnancy Outcome; D012449:Safety; D006113:United Kingdom
D000962:Antimalarials; D006886:Hydroxychloroquine