does intravenous administration of human albumin prevent severe ovarian hyperstimulation syndrome?
OBJECTIVE
To report our experience with i.v. albumin as a means to prevent ovarian hyperstimulation syndrome (OHSS) in high-risk patients.


METHODS
Retrospective case-series.


METHODS
University hospital-based IVF program.


METHODS
Five women undergoing controlled ovarian stimulation for IVF-Based on previous history and/or E2 measurements and number of ovarian follicles, these patients were considered to be at high risk for developing OHSS.


METHODS
Intravenous albumin was given at the time of oocyte retrieval. Additional doses were given 12 and 24 hours later.


METHODS
Development of OHSS.


RESULTS
Four patients developed OHSS; two of them had the severe form of the syndrome.


CONCLUSIONS
Severe OHSS may develop in high-risk patients despite the prophylactic administration of i.v. albumin.
Lewit
N
N
Department of Obsterics and Gynecology, Rambam Medical Center, Haifa, Israel.
Kol
S
S
Ronen
N
N
Itskovitz-Eldor
J
J
D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D016471:Ovarian Hyperstimulation Syndrome / Q000517:prevention & control*; D012189:Retrospective Studies; D012709:Serum Albumin / Q000008:administration & dosage*
D012709:Serum Albumin