Labelling of uric acid and allantoin in different purine organs and urine of the rat.
We studied the incorporation of 14C-formate into uric acid and allantoin in different organs (liver, lung, kidney, spleen), isolated hepatocytes, perfused liver and urine of the rat. Allantoin had a higher specific radioactivity than uric acid after 14C-formate load in the liver in vivo. This was found to be a strictly hepatic phenomenon and not due to the influence of other tissues.
Pizzichini
M
M
Istituto di Biochimica e di Enzimologia, Università di Siena, Italy.
Pandolfi
M L
ML
Arezzini
L
L
Terzuoli
L
L
Fe
L
L
Bontemps
F
F
Van den Berghe
G
G
Marinello
E
E
D000481:Allantoin / Q000378:metabolism* / Q000652:urine; D000818:Animals; D002250:Carbon Radioisotopes; D005561:Formates / Q000378:metabolism*; D007553:Isotope Labeling; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism* / Q000652:urine
D002250:Carbon Radioisotopes; D005561:Formates; C030544:formic acid; D014527:Uric Acid; D000481:Allantoin