title: Prevention of de-novo adhesion formation after laparoscopic myomectomy: a randomized trial to evaluate the effectiveness of an oxidized regenerated cellulose absorbable barrier.
abstract: To evaluate the effectiveness of the oxidized regenerated cellulose absorbable barrier (Interceed, TC7) in the prevention of de-novo adhesion formation after laparoscopic myomectomy, a prospective and randomized study was performed at the Department of Obstetrics and Gynaecology of the University of Cagliari, Cagliari, Italy. A total of 50 pre-menopausal non-pregnant women, aged 23-42 years, who submitted to laparoscopic myomectomy from January 1993 to June 1994, were randomized to surgery alone (control group, n = 25) or surgery and oxidized regenerated cellulose barrier (Interceed group, n = 25). Neither group received any other treatment for adhesion prevention. A second-look laparoscopy was performed 12-14 weeks after laparoscopic myomectomy. The incidence of adhesion-free patients was assessed at second-look laparoscopy by an investigator not informed of the treatment. The numbers of adhesion-free patients were three out of 25 (12%) in the control group and 15 out of 25 (60%) in the treatment group (P < 0.05). In conclusion, the oxidized regenerated cellulose absorbable barrier significantly reduced de-novo adhesion formation after laparoscopic myomectomy.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Cagliari, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Mais
authors.forename: S
authors.initials: S
authors.lastname: Ajossa
authors.forename: B
authors.initials: B
authors.lastname: Piras
authors.forename: S
authors.initials: S
authors.lastname: Guerriero
authors.forename: D
authors.initials: D
authors.lastname: Marongiu
authors.forename: G B
authors.initials: GB
authors.lastname: Melis
mesh_terms: D000328:Adult; D002483:Cellulose, Oxidized / Q000494:pharmacology*; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects*; D007889:Leiomyoma / Q000601:surgery; D009215:Myometrium / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control*; D011446:Prospective Studies; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control*; D014594:Uterine Neoplasms / Q000601:surgery
chemical_list: D002483:Cellulose, Oxidized; C060002:INTERCEED