Evaluation of serum and tissue levels of alpha-tocopherol.
This study was designed to test the effect of supplementation of several antioxidants, including alpha-tocopherol, on the clinical reduction of premalignant oral lesions. Samples of oral mucosa and serum were taken from baseline to 9 months of supplementation from patients with premalignant oral lesions and analyzed for alpha-tocopherol by HPLC. Statistical increases in both serum and tissue alpha-tocopherol were found after supplementation. There was no statistical relationship between alpha-tocopherol and beta-carotene levels.
Brandt
R B
RB
Department of Biochemistry, Medical College of Virginia/Virginia Commonwealth University, Richmond, Virginia, 23298, USA.
Kaugars
G E
GE
Riley
W T
WT
Bei
R A
RA
Silverman
S
S
Lovas
J G
JG
Dezzutti
B P
BP
Chan
W
W
D005260:Female; D006801:Humans; D008297:Male; D009059:Mouth Diseases / Q000188:drug therapy* / Q000473:pathology; D009061:Mouth Mucosa / Q000473:pathology*; D011230:Precancerous Conditions / Q000188:drug therapy* / Q000473:pathology; D012737:Sex Factors; D016896:Treatment Outcome; D019207:beta Carotene / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use
D019207:beta Carotene