[The effect of glucocorticoids on mineral metabolism in bronchial asthma patients].
Nuclear-absorption spectrophotometry (AAC-508, Hitachi, Japan) and selective ionometry (microlyte, Kone, Finland) were employed to measure magnesium and calcium concentrations in the serum, red cells, lymphocytes, 24-h urine and exhaled air moisture in 40 patients with hormone-dependent asthma (BA) and 15 BA patients given beclomet, becotid in inhalations and injections of hydrocortisone, prednisolone and dexason. Intravenous infusions and steroid inhalations in moderate doses for 10-14 days induce only insignificant changes in bivalent cation homeostasis. Complications associated with deranged mineral metabolism occurred more frequently in BA patients on long-term (at least 4 years) courses of oral glucocorticoids. Increased renal and bronchial excretion of magnesium and calcium in patients with hormone-dependent BA with complications of glucocorticoid therapy shows its significant contribution to development of steroid osteopathy and myopathy.
Emel'ianov
A V
AV
Trofimov
V I
VI
D000280:Administration, Inhalation; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000188:drug therapy* / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D005938:Glucocorticoids; D008274:Magnesium; D002118:Calcium