title: Methimazole-induced cholestatic liver injury, mimicking sclerosing cholangitis.
abstract: Cholestatic jaundice caused by imidazole derivates is a rare complication of antithyroid therapy. Only 20 such cases have been reported in the literature since the introduction of methimazole in 1949 and of carbimazole in 1953. We present a further case of methimazole-induced cholestatic liver injury, mimicking sclerosing cholangitis, where the etiology has been proven by a clear chronological relationship and the lack of other causative factors.
authors.affiliation: 2nd Department of Surgery, University of Innsbruck, Austria.
authors.forename: G P
authors.initials: GP
authors.lastname: Schwab
authors.forename: G J
authors.initials: GJ
authors.lastname: Wetscher
authors.forename: W
authors.initials: W
authors.lastname: Vogl
authors.forename: E
authors.initials: E
authors.lastname: Redmond
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D000368:Aged; D013956:Antithyroid Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001653:Bile Ducts, Intrahepatic / Q000000981:diagnostic imaging / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000000981:diagnostic imaging*; D002760:Cholangiopancreatography, Endoscopic Retrograde; D015209:Cholangitis, Sclerosing / Q000139:chemically induced* / Q000000981:diagnostic imaging; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced* / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D006801:Humans; D006980:Hyperthyroidism / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008111:Liver Function Tests; D008297:Male; D008713:Methimazole / Q000009:adverse effects* / Q000627:therapeutic use; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*
chemical_list: D013956:Antithyroid Agents; D008713:Methimazole