title: Further exploration of a latent class typology of schizophrenia.
abstract: We previously derived a typology of schizophrenia from a latent class analysis of 447 first-contact non-affective functional psychotic patients from a defined catchment area. Here, using the same sample, we show that the three subtypes, 'neurodevelopmental' (Type A), 'paranoid' (Type B) and 'schizoaffective' (Type C) have different premorbid, phenomenological and treatment response characteristics. A canonical variate analysis of the three subtypes achieved partial separation between the first two subtypes, but the 'schizoaffective' type was less distinct.
authors.affiliation: Department of Psychological Medicine, Institute of Psychiatry, London, UK.
authors.forename: P C
authors.initials: PC
authors.lastname: Sham
authors.forename: D J
authors.initials: DJ
authors.lastname: Castle
authors.forename: S
authors.initials: S
authors.lastname: Wessely
authors.forename: A E
authors.initials: AE
authors.lastname: Farmer
authors.forename: R M
authors.initials: RM
authors.lastname: Murray
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D019965:Neurocognitive Disorders / Q000145:classification* / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D010553:Personality Development; D010554:Personality Disorders / Q000145:classification / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D011618:Psychotic Disorders / Q000145:classification* / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D012307:Risk Factors; D012559:Schizophrenia / Q000145:classification* / Q000175:diagnosis / Q000235:genetics; D012563:Schizophrenia, Paranoid / Q000145:classification* / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D012565:Schizophrenic Psychology; D012917:Social Adjustment