title: High-affinity anti-DNA antibody parallels clinical course of immunoadsorption therapy for systemic lupus erythematosus.
abstract: Anti-DNA antibody, especially high-affinity anti-DNA antibody (ADNA), is thought to have an important role in the pathogenesis of lupus nephritis. In this study, ADNA which binds to double-stranded DNA under a high concentration of sodium chloride was measured in patients who had received immunoadsorption (IA) therapy with a dextran-sulfate column. Titers of high-affinity ADNA in the cases with renal dysfunction tended to be higher than in those without renal dysfunction. The change in the titer of high-affinity ADNA paralleled the clinical course. These findings suggest that measurement of high-affinity ADNA is useful for follow-up of the clinical course of patients who have undergone IA therapy.
authors.affiliation: Third Department of Internal Medicine, Kinki University School of Medicine, Osaka.
authors.forename: M
authors.initials: M
authors.lastname: Funauchi
authors.forename: S
authors.initials: S
authors.lastname: Ikoma
authors.forename: H
authors.initials: H
authors.lastname: Enomoto
authors.forename: M
authors.initials: M
authors.lastname: Ohno
authors.forename: K
authors.initials: K
authors.lastname: Kinoshita
authors.forename: A
authors.initials: A
authors.lastname: Horiuchi
authors.forename: N
authors.initials: N
authors.lastname: Kurata
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood* / Q000276:immunology; D000915:Antibody Affinity; D001327:Autoimmune Diseases / Q000097:blood / Q000276:immunology / Q000628:therapy*; D002846:Chromatography, Affinity; D004247:DNA / Q000276:immunology*; D016264:Dextran Sulfate; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007163:Immunosorbent Techniques; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology / Q000628:therapy*; D008181:Lupus Nephritis / Q000097:blood / Q000276:immunology / Q000628:therapy; D010956:Plasmapheresis
chemical_list: D000974:Antibodies, Antinuclear; D004247:DNA; D016264:Dextran Sulfate