title: Prolonged, complete remission after 2-chlorodeoxyadenosine therapy in a patient with refractory essential mixed cryoglobulinemia.
abstract: Essential mixed cryoglobulinemia is a systemic disorder in which cutaneous vasculitis and frequently glomerulonephritis are associated with cryoprecipitable serum immune complexes. Typically, the treatment regimen consists of plasmapheresis, high-dose corticosteroids, and cytotoxic chemotherapy, as well as interferon alfa for hepatitis C virus-related cryoglobulinemia. Herein we describe a man with progressive, symptomatic cryoglobulinemia and multisystem organ dysfunction in whom corticosteroid and alkylating therapy failed; however, he had a complete and long-lasting remission after administration of 2-chlorodeoxyadenosine (cladribine).
authors.affiliation: Division of Hematology and Oncology, Ida M. and Cecil H. Green Cancer Center, Scripps Clinic and Research Foundation, La Jolla, California 92037, USA.
authors.forename: T C
authors.initials: TC
authors.lastname: Lee
authors.forename: W E
authors.initials: WE
authors.lastname: Miller
authors.forename: J G
authors.initials: JG
authors.lastname: Curd
authors.forename: L D
authors.initials: LD
authors.lastname: Piro
authors.forename: A
authors.initials: A
authors.lastname: Saven
mesh_terms: D000368:Aged; D017338:Cladribine / Q000627:therapeutic use*; D003449:Cryoglobulinemia / Q000188:drug therapy*; D018450:Disease Progression; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D012074:Remission Induction
chemical_list: D007166:Immunosuppressive Agents; D017338:Cladribine