Comparative effects of dopexamine and dopamine on glycerol-induced acute renal failure in rats.
Acute renal failure (ARF) was induced in rats by intramuscular injection of 50% glycerol, 10 mL/kg body weight. Rats were given isotonic saline (1.5 mL/h) dopexamine hydrochloride (dopexamine, 100 microg/h) or dopamine (100 microg/h), commencing either immediately after glycerol administration and maintained during all the observation time (90 min, acute studies) or 20 min before administration of glycerol and during 60 min (chronic studies). Renal function was assessed during 90 min after induction of ARF in anesthetized rats and during 3 days following ARF induction in conscious animals. In anesthetized rats treated with dopexamine or dopamine, the reduction in insulin and para-aminohippuric acid clearance was markedly lower than that observed in untreated animals. In conscious animals, urinary flow and creatinine clearance were higher in rats treated with dopamine or dopexamine than in the non-treated group. Rats treated with dopexamine had higher renal Na+ and K+ excretion than dopamine-treated rats. Survival was higher in the dopexamine group than in either of the other two groups. These results demonstrate that pretreatment with dopexamine or dopamine significantly improves the course of ARF, with better survival after treatment with dopexamine.
Gömez-Garre
D N
DN
Instituto Reina Sofia de Investigaciones Nefrológicas, Departamento deFisiología y Farmacología, Universidad de Salamanca, Spain.
López-Farré
A
A
Eleno
N
N
López-Novoa
J M
JM
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D000318:Adrenergic beta-Agonists / Q000627:therapeutic use*; D000818:Animals; D004195:Disease Models, Animal; D004298:Dopamine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D018491:Dopamine Agonists / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005919:Glomerular Filtration Rate / Q000187:drug effects; D005990:Glycerol; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017595:Renal Plasma Flow / Q000187:drug effects; D013997:Time Factors
D000318:Adrenergic beta-Agonists; D018491:Dopamine Agonists; C046318:dopexamine; D005990:Glycerol; D004298:Dopamine