The role of host immune responses in determining the outcome of HIV infection.
The progression of disease following infection with human immunodeficiency virus (HIV) correlates with an activated immune system and would appear to depend to some degree on the immunogenetics of the host. Here, Michael Westby, Fabrizio Manca and Angus Dalgleish discuss the evidence for HLA determination of clinical outcome and the potential implications of a restricted T-cell receptor repertoire for pathogenesis.
Westby
M
M
Division of Oncology, Cellular and Molecular Sciences, St George's Hospital Medical School, Tooting, UK. dalgleis@sghms.ac.uk
Manca
F
F
Dalgleish
A G
AG
D000595:Amino Acid Sequence; D001483:Base Sequence; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000032:analysis / Q000502:physiology; D018089:Superantigens / Q000502:physiology
D016693:Receptors, Antigen, T-Cell, alpha-beta; D018089:Superantigens