Design and analysis of lipid tracer kinetic studies.
A fundamental problem in lipid metabolism is designing experiments to quantitate the kinetics of the plasma lipids and lipoproteins in the body. Tracers have been used extensively. In this review, we will combine our knowledge of the theory and application of tracer kinetic studies to discuss current state of the art methodologies for lipid metabolism. We will review the use of stable and radioactive isotopes pointing out the importance of the measurement variables, and the theory and application of noncompartmental and compartmental models to interpret the data.
Hugh
P
P
Center for Bioengineering, University of Washington, Seattle 98195, USA.
Barrett
R
R
Foster
D M
DM
D006801:Humans; D007700:Kinetics; D008074:Lipoproteins / Q000378:metabolism*; D008954:Models, Biological; D011868:Radioisotopes
D008074:Lipoproteins; D011868:Radioisotopes