Evolution of senescence: Alzheimer's disease and evolution.
The genetic basis of Alzheimer's disease is becoming clear; it appears to fit the postulates of the two main theories of the evolution of senescence, with both polymorphic alleles and rare mutations involved.
Charlesworth
B
B
Department of Ecology and Evolution, University of Chicago, Illinois 60637-1573, USA.
D000375:Aging / Q000235:genetics*; D000544:Alzheimer Disease / Q000235:genetics*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics; D005075:Biological Evolution; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D009154:Mutation; D011110:Polymorphism, Genetic; D053766:Presenilin-2
D016564:Amyloid beta-Protein Precursor; D001057:Apolipoproteins E; D008565:Membrane Proteins; C508861:PSEN2 protein, human; D053766:Presenilin-2; C095101:Psen2 protein, mouse