title: Evaluation for intrinsic skin permeation of unstable compounds.
abstract: An evaluation method is proposed for the intrinsic skin permeation rate of unstable compounds. Vitamin C and vitamin E were used as the model compounds. The degradation of vitamin C and E in the solutions followed first-order kinetics with degradation constants of 0.26 h-1 and 0.014 h-1, respectively. The apparent skin permeation profiles of vitamin C and E in vitro, approximated by a nonlinear profile of the polynomial regression method, was corrected for intrinsic permeation rate considering first-order degradation in the receptor solution. The intrinsic profiles evaluated agreed well with the ones determined from radio-labelled compounds, indicating the feasibility of the present analysis.
authors.affiliation: Controlled Drug Delivery Research Center, College of Pharmacy, Rutgers University, Piscataway, NJ 08855-0789, USA.
authors.forename: A R
authors.initials: AR
authors.lastname: Lee
authors.forename: K
authors.initials: K
authors.lastname: Tojo
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000737:chemistry / Q000493:pharmacokinetics*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005260:Female; D066298:In Vitro Techniques; D051379:Mice; D008812:Mice, Hairless; D014677:Pharmaceutical Vehicles; D012869:Skin Absorption; D014810:Vitamin E / Q000737:chemistry / Q000493:pharmacokinetics*
chemical_list: D014677:Pharmaceutical Vehicles; D014810:Vitamin E; D001205:Ascorbic Acid