Differential roles for IL-12 in the maintenance of immune responses in infectious versus autoimmune disease.
IL-12 has been shown to be important in the generation of a functional Th1 response in animal models of both infectious and autoimmune disease. Furthermore, the role of IL-12 in the maintenance of the immune responses in these diseases is now emerging. Herein, we discuss the idea that memory responses for certain infections may be IL-12 independent, whereas memory responses for specific autoimmune diseases still require IL-12 to maintain a pathogenic response.
Seder
R A
RA
Laboratory of Clinical Investigation, National Institutes of Health, Bethesda, MD 20892, USA. rseder@nih.gov
Kelsall
B L
BL
Jankovic
D
D
D000276:Adjuvants, Immunologic; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D006801:Humans; D007114:Immunization; D007121:Immunocompetence; D007156:Immunologic Memory; D007239:Infections / Q000276:immunology*; D007371:Interferon-gamma / Q000502:physiology; D018664:Interleukin-12 / Q000502:physiology*; D051379:Mice; D018417:Th1 Cells / Q000276:immunology*
D000276:Adjuvants, Immunologic; D018664:Interleukin-12; D007371:Interferon-gamma