title: Central precocious puberty following feminizing right ovarian granulosa cell tumor.
abstract: A 7-month-old girl presented with ascites and breast enlargement due to right ovarian granulosa cell tumor. After tumor removal, the clinical signs of incomplete precocious puberty regressed. Four years later, the patient reappeared with signs of precocious puberty. Our investigations proved that this was not due to tumor recurrence, but it was a true central precocious puberty. She responded well to therapy with a luteinizing hormone releasing hormone agonist, and 3 years after onset of this therapy, she is growing at a normal prepubertal rate.
authors.affiliation: Department of Paediatrics, McGill University, Montreal, Que., Canada.
authors.forename: A
authors.initials: A
authors.lastname: Kukuvitis
authors.forename: C
authors.initials: C
authors.lastname: Matte
authors.forename: C
authors.initials: C
authors.lastname: Polychronakos
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D005260:Female; D006106:Granulosa Cell Tumor / Q000150:complications* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007223:Infant; D016729:Leuprolide / Q000627:therapeutic use; D010051:Ovarian Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D011629:Puberty, Precocious / Q000188:drug therapy / Q000209:etiology*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D016729:Leuprolide