title: Skip metastasis to the mediastinal lymph nodes in non-small cell lung cancer.
abstract: BACKGROUND
  Whether any difference exists in clinical characteristics between resected non-small cell lung cancer with either skip or ordinary mediastinal lymph node metastases (N2 disease) needs to be clarified.
  
  
  METHODS
  There were 110 patients with stage IIIA N2 disease. Thirty-three patients demonstrating no metastasis at the hilar nodes [skip (+) group] were compared with the other 77 patients [skip (-) group]. To investigate the extent of nodal involvement, we classified the mediastinal lymph nodes into three regions (superior, inferior, or aortic).
  
  
  RESULTS
  There were no significant differences regarding histologic type, T status, or the site of the primary tumors between the skip (+) and the skip (-) N2 groups. In the skip (+) group, mediastinal node metastasis was found in only one region (level 1) in 30 patients (90.9%) and in two regions (level 2) in 3 (9.1%), whereas 28 patients (36.4%) from the skip (-) group revealed mediastinal metastasis at two or three regions (level 2 or 3). The overall survival rate at 5 years after operation was 35% in the skip (+) group and 12.7% in the skip (-) group (p = 0.054). This favorable clinical outcome in the skip (+) group could be explained partially by the higher proportion of patients with level 1 metastases. Furthermore, regarding patients with level 1 disease, the skip (+) group tended to have a better prognosis than the skip (-) group (p = 0.096).
  
  
  CONCLUSIONS
  These results suggest that patients with skip mediastinal lymph node metastases represent a unique subgroup of N2 disease.
authors.affiliation: Department of Chest Surgery, National Kyushu Cancer Center, Fukuoka, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Yoshino
authors.forename: H
authors.initials: H
authors.lastname: Yokoyama
authors.forename: T
authors.initials: T
authors.lastname: Yano
authors.forename: T
authors.initials: T
authors.lastname: Ueda
authors.forename: E
authors.initials: E
authors.lastname: Takai
authors.forename: K
authors.initials: K
authors.lastname: Mizutani
authors.forename: H
authors.initials: H
authors.lastname: Asoh
authors.forename: Y
authors.initials: Y
authors.lastname: Ichinose
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008482:Mediastinum; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate