title: Neuromuscular disorders in patients with intermittent claudication.
abstract: OBJECTIVE
  To evaluate the effect of claudication on nerve function in patients with unilateral peripheral arterial disease.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  District hospital, The Netherlands.
  
  
  METHODS
  11 Patients with unilateral intermittent claudication (diagnosed from history and ankle-brachial blood pressure index) underwent electrophysiological studies of both legs, including nerve conduction velocities, motor unit action potentials, H-reflex measurements, and muscle strength testing. The asymptomatic leg was used as the control in each case.
  
  
  RESULTS
  Six patients had neuropathy in both the claudicating and the control leg. Three other patients had neuropathy in the claudicating leg only, which consisted mainly of disorders of nerve conduction including the H-reflex. There was no clear difference between muscle strength in the symptomatic and control legs, possibly because more than half the patients studied, had neuropathy in both legs.
  
  
  CONCLUSIONS
  Neuropathy is common at an early stage of arterial disease and could be one of the factors leading to impaired muscle function in such patients.
authors.affiliation: Department of Surgery, Westeinde Hospital, The Hague, The Netherlands.
authors.forename: J P
authors.initials: JP
authors.lastname: Koopman
authors.forename: A C
authors.initials: AC
authors.lastname: de Vries
authors.forename: A W
authors.initials: AW
authors.lastname: de Weerd
mesh_terms: D000200:Action Potentials; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004576:Electromyography; D005260:Female; D006181:H-Reflex; D006801:Humans; D007383:Intermittent Claudication / Q000150:complications*; D007866:Leg / Q000294:innervation; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000503:physiopathology; D009431:Neural Conduction; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D011446:Prospective Studies