Lessons from human genetic variants in the study of B-cell differentiation.
Several human B-cell immunodeficiencies result from mutations in signal transducing molecules. The past year has seen significant advances in our understanding of how these molecules are integrated into B cell signaling pathways. The phenotypes of mice deficient in several of these genes have revealed species-specific differences in the requirements for early B cell development.
Satterthwaite
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Department of Microbiology and Molecular Genetics, University of California, Los Angeles, CA 90095-1662, USA. annes@microbio.lifesci.ucla.edu
Witte
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D000818:Animals; D001402:B-Lymphocytes / Q000473:pathology*; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics* / Q000473:pathology*