Clinical information on serum IGFBP-3 levels and IGFBP-3 proteolytic activity in childhood.
In this review paper, three pieces of clinical information in childhood are presented: (1) IGFBP-3 may replace GH provocation tests in the diagnosis of GH deficiency (GHD); (2) IGFBP-3 levels are regulated by IGF-I levels in a short period, and (3) ratio of free IGF-I to total IGF-I is high in serum of early infancy, similarly to serum of pregnancy, only partially owing to the presence of IGFBP-3 proteolytic activity. Each paper will be published soon.
Hasegawa
Y
Y
Division of Endocrinology and Metabolism, Tokyo Metropolitan Kiyose Children's Hospital, Japan.
Hasegawa
T
T
Fujii
K
K
Konii
H
H
Anzo
M
M
Aso
T
T
Kotoh
S
S
Tsuchiya
Y
Y
D000293:Adolescent; D000328:Adult; D001120:Arginine; D002648:Child; D002675:Child, Preschool; D006130:Growth Disorders / Q000175:diagnosis*; D019382:Human Growth Hormone / Q000172:deficiency* / Q000378:metabolism; D006801:Humans; D007223:Infant; D007328:Insulin; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*
D007328:Insulin; D018972:Insulin-Like Growth Factor Binding Protein 3; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D001120:Arginine