title: Eosinophils and basophilic cells in sputum and nasal smears taken from infants and young children during acute asthma.
abstract: To examine the increase in eosinophils and basophilic cells in the respiratory areas of infants and young children with asthma (n = 111), we analyzed the numbers of eosinophils and basophilic cells in sputum and nasal smears. The number of children with eosinophilia grades of 2+ or greater (> or = 11 cells/five fields in x1000 magnification) in sputum and nasal smears, respectively, in each age group was as follows: 33% and 21% under 1 year, 59% and 64% at 1 year, and 79-80% and 75-78% at 2-3 years. An increased infiltration of basophilic cells according to age was also observed. Infiltration of these cells began earlier than the appearance of IgE antibodies to mite in blood.
authors.affiliation: Department of Allergy and Respiratory Disease, Chiba Children's Hospital, Chiba City, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nagayama
authors.forename: Y
authors.initials: Y
authors.lastname: Odazima
authors.forename: S
authors.initials: S
authors.lastname: Nakayama
authors.forename: T
authors.initials: T
authors.lastname: Toba
authors.forename: S
authors.initials: S
authors.lastname: Funabashi
mesh_terms: D000208:Acute Disease; D001249:Asthma / Q000276:immunology* / Q000473:pathology; D001491:Basophils / Q000473:pathology*; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D002675:Child, Preschool; D004804:Eosinophils / Q000473:pathology*; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D017817:Nasal Lavage Fluid / Q000166:cytology*; D011852:Radioallergosorbent Test; D013183:Sputum / Q000166:cytology*