title: Erythema nodosum caused by omeprazole.
abstract: We report a case of erythema nodosum caused by omeprazole. This side effect of omeprazole has not been previously reported. A 35-year-old white woman developed multiple tender erythematous nodules over the anterior aspect of her upper and lower extremities, fever, malaise, and edema. Her symptoms resolved with withdrawal of all preexisting medications and conservative treatment. Her symptoms flared soon after a rechallenge with omeprazole. A thorough history, physical examination, laboratory evaluation, and roentgenogram failed to reveal another cause for erythema nodosum. It is clear from the rechallenge that this patient's erythema nodosum was caused by omeprazole. We consider that omeprazole should be added to the list of medications known to cause erythema nodosum.
authors.affiliation: Department of Dermatology, Wilford Hall Medical Center, Lackland Air Force Base, Texas 78236-5300, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Ricci
authors.forename: K C
authors.initials: KC
authors.lastname: Deering
mesh_terms: D000328:Adult; D000897:Anti-Ulcer Agents / Q000009:adverse effects*; D001132:Arm; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D004487:Edema / Q000139:chemically induced; D004893:Erythema Nodosum / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D007868:Leg Dermatoses / Q000139:chemically induced / Q000473:pathology; D008487:Medical History Taking; D009853:Omeprazole / Q000009:adverse effects*; D010808:Physical Examination
chemical_list: D000897:Anti-Ulcer Agents; D009853:Omeprazole