CD30-positive T cell lymphoma of the intestine, complicating ulcerative colitis.
Large cell lymphoma with massive necrosis and a phagocytic reaction (malignant histiocytosis-type lymphoma) occurred multifocally in the small and large intestine of a 52 year old male, who had suffered from ulcerative colitis of a pancolonic type for 2 years. After total colectomy and partial jejunectomy, the tumor recurred repeatedly during the subsequent 3-year period. He died of massive intestinal hemorrhage with mild regional lymph nodal involvement. Surface marker studies disclosed CD4/CD8-double negative and CD30+ T cell features. CD3 was weakly expressed. Epstein-Barr virus infection was not identified. The relationship of this neoplasm with 'enteropathy-associated T cell lymphoma' and intestinal Ki-1 lymphoma is discussed.
Tsutsuml
Y
Y
Department of Pathology, Tokai University School of Medicine, Isehara, Japan.
Nakamura
M
M
Machimura
T
T
D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D003093:Colitis, Ulcerative / Q000150:complications* / Q000473:pathology; D003937:Diagnosis, Differential; D054747:Histiocytic Sarcoma / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007414:Intestinal Neoplasms / Q000150:complications / Q000276:immunology* / Q000473:pathology; D017730:Ki-1 Antigen / Q000032:analysis*; D016399:Lymphoma, T-Cell / Q000150:complications / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010641:Phenotype
D015704:CD4 Antigens; D016827:CD8 Antigens; D017730:Ki-1 Antigen