Inheritance of Chediak-Higashi syndrome in Japanese black cattle.
Fifty-six Japanese black cattle affected with Chediak-Higashi syndrome (C-HS) have been referred to Miyazaki University Veterinary Teaching Hospital during the past 12 years, and 44 pedigree records were collected. In pedigree analysis, the parents had no clinical sign, the affected dams had clinically normal calves, and approximately equal numbers of males and females were affected, we therefore considered this syndrome to be an autosomal recessive trait. Quantitative genetic analyses were then made in a restricted area. Segregation analysis by the a priori method in 8 families showed that C-HS was a simple autosomal recessive trait. Furthermore, 36 dams and their 257 offspring (including 8 C-HS affected cattle) were analyzed using population genetics in the same area. The result was the same as in the former analysis.
Tu
C H
CH
Department of Veterinary Surgery, Faculty of Agriculture, Miyazaki University, Japan.
Takahashi
Y
Y
Kaseda
Y
Y
Uchida
K
K
Yamaguchi
R
R
Suzuki
K
K
Ogawa
H
H
Otsuka
H
H
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000235:genetics*; D002609:Chediak-Higashi Syndrome / Q000235:genetics / Q000662:veterinary*; D005260:Female; D005787:Gene Frequency; D005808:Genes, Recessive; D006580:Genetic Carrier Screening; D007564:Japan; D008297:Male; D010375:Pedigree; D012727:Sex Characteristics