title: Effect of sympathoadrenal blockade on the hyperglycemic action of angiotensin II.
abstract: The present experiments were designed to investigate the influence of the sympathoadrenal system on the hyperglycemic action of angiotensin II in freely moving rats divided into four experimental groups: (1) sham-operated animals submitted to intravenous administration of angiotensin II (1.9 nmol) which caused a rapid increase in plasma glucose reaching the highest values at 5 min after the injection (26.5% of the initial values; P < 0.01); (2) Sham-operated animals submitted to blockade of sympathetic noradrenergic pathways by treatment with guanethidine (10 mg/100 g body weight), which greatly decreased the baseline value of plasma glucose (85 +/- 5.5 mg% vs 136 +/- 5.1 mg% P < 0.01), and increased the hyperglycemic response to angiotensin II by 96% (P < 0.01); (3) Animals submitted to adrenodemedullation that did not alter the hyperglycemic response to angiotensin II; (4) Adrenodemedullated animals submitted to sympathetic blockade by guanethidine treatment which caused a 40.5% decrease in the hyperglycemic response to angiotensin II (P < 0.05). These data indicate that angiotensin II has a direct hyperglycemic effect in addition to its action on sympathetic nervous system activation and adrenomedullary secretion.
authors.affiliation: Department of Physiology and Biophysics, Federal University of Minas Gerais, Brazil.
authors.forename: I
authors.initials: I
authors.lastname: Mihessen-Neto
authors.forename: A M
authors.initials: AM
authors.lastname: Reis
authors.forename: U
authors.initials: U
authors.lastname: Marubayashi
authors.forename: C C
authors.initials: CC
authors.lastname: Coimbra
mesh_terms: D000313:Adrenal Medulla / Q000601:surgery; D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D006145:Guanethidine / Q000494:pharmacology; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology*; D013565:Sympatholytics / Q000494:pharmacology
chemical_list: D001786:Blood Glucose; D013565:Sympatholytics; D000804:Angiotensin II; D006145:Guanethidine