Cyclic nucleotide-gated ion channels: an extended family with diverse functions.
An ion channel directly activated by cGMP was first discovered about ten years ago. Since then, a number of ion channels with the same property (cyclic nucleotide-activated channels) have been reported that are involved in a variety of cell functions. In addition, other channels have been found that are not primarily controlled by cyclic nucleotides but are modulated by them (cyclic nucleotide-modulated channels). These channels likewise have diverse functions and tissue distributions. Both channel classes are reviewed here. Coverage includes the cyclic-nucleotide binding site on these channels, ion permeation, pharmacological blockers, channel gating and modulation, and physiological functions of the channels.
Finn
J T
JT
Thomas C. Jenkins Department of Biophysics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Grunwald
M E
ME
Yau
K W
KW
D000595:Amino Acid Sequence; D000818:Animals; D000242:Cyclic AMP / Q000502:physiology*; D006152:Cyclic GMP / Q000502:physiology*; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology*; D008969:Molecular Sequence Data
D007473:Ion Channels; D000242:Cyclic AMP; D006152:Cyclic GMP