title: Early and late morbidity in patients undergoing pulmonary resection with low diffusion capacity.
abstract: BACKGROUND
  We sought to determine whether low diffusion capacity of the lung to carbon monoxide (DLCO) is a predictor of high postoperative mortality and morbidity after major pulmonary resection and whether major pulmonary resection in patients with low DLCO results in substantial long-term morbidity.
  
  
  METHODS
  Sixty-two major pulmonary resections were performed in 61 patients with low DLCO (DLCO < or = 60% predicted for pneumonectomy or bilobectomy; < or = 50% predicted for lobectomy). Contemporaneously, 262 other patients underwent 263 major pulmonary resections (group II). Long-term morbidity was assessed in subsets of patients with low (n = 24) and high (n = 22; DLCO > 60% predicted) DLCO.
  
  
  RESULTS
  The hospital mortality rates were equivalent (4.8% low DLCO versus 4.9% group II), whereas respiratory complications were more frequent in patients with low DLCO (18% versus 9.5%; p = 0.05). In the subgroup analyses, patients with low DLCO had more hospitalizations for respiratory compromise and worse median dyspnea scores. Analysis of patients with substantial dyspnea revealed an association with extended pulmonary resection and postoperative radiation therapy in patients with low DLCO.
  
  
  CONCLUSIONS
  Patients with low DLCO underwent major pulmonary resection with a low mortality rate and an acceptable, but increased, respiratory complication rate. Long-term respiratory morbidity was increased in patients with low DLCO; however, the extent of pulmonary resection and the use of postoperative radiation therapy may have contributed to the development of dyspnea in these patients.
authors.affiliation: Department of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee 53226, USA.
authors.forename: M
authors.initials: M
authors.lastname: Bousamra
authors.forename: K W
authors.initials: KW
authors.lastname: Presberg
authors.forename: J H
authors.initials: JH
authors.lastname: Chammas
authors.forename: J S
authors.initials: JS
authors.lastname: Tweddell
authors.forename: B L
authors.initials: BL
authors.lastname: Winton
authors.forename: M R
authors.initials: MR
authors.lastname: Bielefeld
authors.forename: G B
authors.initials: GB
authors.lastname: Haasler
mesh_terms: D000368:Aged; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy / Q000009:adverse effects* / Q000401:mortality; D011183:Postoperative Complications; D011653:Pulmonary Diffusing Capacity; D012307:Risk Factors; D014797:Vital Capacity