title: Immunoglobulin A-specific serodiagnosis of acute human cytomegalovirus infection by using recombinant viral antigens.
abstract: The immunoglobulin A-specific reactivities of recombinant viral proteins from nine different reading frames of human cytomegalovirus were evaluated in enzyme-linked immunosorbent assay experiments. Antigen fragments of reading frames pUL32, pUL44, and pUL57 were identified as preferable antigens for immunoglobulin A serodiagnosis. Application of autologous fusion proteins which combine these polypeptides may be useful especially for the early detection of acute secondary human cytomegalovirus infection.
authors.affiliation: Research Department, Biotest AG, Dreieich, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Vornhagen
authors.forename: W
authors.initials: W
authors.lastname: Hinderer
authors.forename: H H
authors.initials: HH
authors.lastname: Sonneborn
authors.forename: G
authors.initials: G
authors.lastname: Bein
authors.forename: L
authors.initials: L
authors.lastname: Matter
authors.forename: T H
authors.initials: TH
authors.lastname: The
authors.forename: G
authors.initials: G
authors.lastname: Jahn
authors.forename: B
authors.initials: B
authors.lastname: Plachter
mesh_terms: D000208:Acute Disease; D000914:Antibodies, Viral / Q000097:blood*; D000956:Antigens, Viral / Q000235:genetics; D003587:Cytomegalovirus / Q000235:genetics / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005069:Evaluation Studies as Topic; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D016364:Reading Frames; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000276:immunology; D012698:Serologic Tests / Q000379:methods*; D013997:Time Factors
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D007070:Immunoglobulin A; D011993:Recombinant Fusion Proteins