Serum lidocaine concentrations after subcutaneous administration in patients undergoing cardiac catheterization in a pediatric institution.
OBJECTIVE
We wished to determine serum lidocaine concentrations after subcutaneous injection during cardiac catheterization.


METHODS
Serum lidocaine concentrations were measured in 50 patients during catheterization.


RESULTS
Serum concentration was linearly related to dose per kilogram of body weight. Lidocaine concentrations were therapeutic in 38% of patients.


CONCLUSIONS
Lidocaine dose must be considered when the drug is used for local anesthesia in children.
Cassidy
S C
SC
Department of Pediatrics, Ohio State University, Columbus, USA.
Jones
P R
PR
Cox
S
S
Walson
P D
PD
Allen
H D
HD
D000779:Anesthetics, Local / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006328:Cardiac Catheterization; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007279:Injections, Subcutaneous; D008012:Lidocaine / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics
D000779:Anesthetics, Local; D008012:Lidocaine