title: Effects of joining peptide (1-18) and histamine on dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS) production of human adrenocortical cells in vitro.
abstract: Joining peptide 1-18 (JP 1-18), added alone in concentrations of 10(-13)-10(-7) M to collagenase-dispersed human adrenocortical cells, did not affect the basal production of corticosterone, cortisol, aldosterone, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS). JP 1-18 potentiated the ACTH-stimulated production of steroids. When administered in combination with histamine (10(-8)-10(-3) M), JP 1-18 (10(-8) or 10(-10) M), enhanced the synthesis of DHEA and DHEAS. JP 1-18, together with histamine, may play a role in the regulation of DHEA and DHEAS production.
authors.affiliation: Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary.
authors.forename: E
authors.initials: E
authors.lastname: Orsó
authors.forename: K S
authors.initials: KS
authors.lastname: Szalay
authors.forename: D
authors.initials: D
authors.lastname: Szabó
authors.forename: E
authors.initials: E
authors.lastname: Stark
authors.forename: T
authors.initials: T
authors.lastname: Fehér
authors.forename: F
authors.initials: F
authors.lastname: Perner
authors.forename: M
authors.initials: M
authors.lastname: Hidvégi
mesh_terms: D000302:Adrenal Cortex / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000595:Amino Acid Sequence; D003687:Dehydroepiandrosterone / Q000378:metabolism*; D019314:Dehydroepiandrosterone Sulfate / Q000378:metabolism; D004357:Drug Synergism; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000494:pharmacology*; D011333:Pro-Opiomelanocortin / Q000494:pharmacology*
chemical_list: D010446:Peptide Fragments; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; D011333:Pro-Opiomelanocortin; D006632:Histamine; D000324:Adrenocorticotropic Hormone