title: Engineering and design of blood substitutes.
abstract: Clinical experiences with chemically modified and genetically engineered hemoglobin blood substitutes have uncovered new side-effects that must be addressed before a viable oxygen-carrying alternative to blood can be developed. These include, among others, vasoactivity and rapid autoxidation resulting in free-radical-mediated toxicity. Research is now being directed towards understanding the mechanisms of these toxic side-effects and developing methods of overcoming them.
authors.affiliation: Beckman Institute, 405 North Mathews, Urbana, Illinois 61801, USA.
authors.forename: K E
authors.initials: KE
authors.lastname: Sanders
authors.forename: G
authors.initials: G
authors.lastname: Ackers
authors.forename: S
authors.initials: S
authors.lastname: Sligar
mesh_terms: D001802:Blood Substitutes / Q000633:toxicity; D002986:Clinical Trials as Topic; D006454:Hemoglobins / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D015202:Protein Engineering
chemical_list: D001802:Blood Substitutes; D006454:Hemoglobins