[The effect of the blood corrective agent Lactosorbal on liver functional activity in dogs with a model of severe hemorrhagic shock].
A new complex action hemocorrective <<Lactosorbal>> was studied for its effect on functional activity of the liver, for which purpose a total of 5 dogs subjected to severe hemorrhagic shock were used. Apart from marked hemodynamic effects the <<Lactosorbal>> intravenous transfusions (10 ml/kg) promote restoration of hepatic functions and survival of animals. Possible modes of action responsible for therapeutic effect of <<Lactosorbal>> are considered. The results of the present study serve to experimentally substentiate the use of <<Lactosorbal>> in combined therapy of grave forms of shock of different genesis during all stages of medical evacuation as well as of acute renal insufficiency in clinical settings.
Oborin
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AN
Mindiuk
M V
MV
D000208:Acute Disease; D000818:Animals; D001802:Blood Substitutes / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D012709:Serum Albumin / Q000627:therapeutic use*; D012771:Shock, Hemorrhagic / Q000503:physiopathology / Q000628:therapy*; D013011:Sorbic Acid / Q000627:therapeutic use*; D013997:Time Factors
D001802:Blood Substitutes; D012709:Serum Albumin; C091503:lactosorbal; D013011:Sorbic Acid