title: The versatility of phosphoenolpyruvate and its vinyl ether products in biosynthesis.
abstract: The diverse enzymes that use phosphoenolpyruvate as a substrate lie at the heart of cellular energy metabolism, as well as a number of critical biosynthetic pathways. The versatility of the enol ether linkage is reflected not only in the rich chemistry and enzymology of PEP, but also in the variety of metabolites in which the high-energy enol ether linkage is preserved.
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
authors.forename: C T
authors.initials: CT
authors.lastname: Walsh
authors.forename: T E
authors.initials: TE
authors.lastname: Benson
authors.forename: D H
authors.initials: DH
authors.lastname: Kim
authors.forename: W J
authors.initials: WJ
authors.lastname: Lees
mesh_terms: D004734:Energy Metabolism; D004798:Enzymes / Q000378:metabolism; D015335:Molecular Probes; D010728:Phosphoenolpyruvate / Q000378:metabolism*; D011134:Polysaccharides / Q000378:metabolism; D013379:Substrate Specificity; D014753:Vinyl Compounds / Q000378:metabolism*
chemical_list: D004798:Enzymes; D015335:Molecular Probes; D011134:Polysaccharides; D014753:Vinyl Compounds; C100195:vinyl ether; D010728:Phosphoenolpyruvate