The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans.
The Candida albicans HOG1 gene (HOG1CA) was cloned by functional complementation of the osmosensitive phenotype associated with Saccharomyces cerevisiae hog1 delta mutants. HOG1CA codes for a 377-amino-acid protein, 78% identical to S. cerevisiae Hog1p. A C. albicans hog1 null mutant was found to be sensitive to osmotic stress and failed to accumulate glycerol on high-osmolarity media.
San José
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Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Spain.
Monge
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Pérez-Díaz
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Pla
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Nombela
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D000222:Adaptation, Physiological / Q000235:genetics; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000235:genetics*; D002176:Candida albicans / Q000235:genetics*; D003001:Cloning, Molecular; D005800:Genes, Fungal; D005816:Genetic Complementation Test; D005990:Glycerol / Q000378:metabolism*; D020928:Mitogen-Activated Protein Kinases; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D009997:Osmotic Pressure; D010641:Phenotype; D029701:Saccharomyces cerevisiae Proteins; D017422:Sequence Analysis, DNA; D015398:Signal Transduction / Q000235:genetics
D029701:Saccharomyces cerevisiae Proteins; D017871:Calcium-Calmodulin-Dependent Protein Kinases; C088589:HOG1 protein, S cerevisiae; D020928:Mitogen-Activated Protein Kinases; D005990:Glycerol