title: Intercellular adhesion molecule-1 (ICAM-1) immunoreactivity in well-differentiated thyroid papillary carcinomas.
abstract: Fifty-nine cases of tumors, 51 taken from the thyroid gland including 17 well-differentiated papillary, 1 medullary and 3 follicular carcinomas, 14 follicular adenomas, 16 nodular goiters and 8 cases selected from other sites; 5 breast carcinomas; 1 melanoma; 1 Merkel cell tumor; and 1 squamous cell carcinoma of the uterine cervix, were investigated for intercellular adhesion molecule-1 (ICAM-1) expression. All cases of well-differentiated papillary thyroid carcinoma showed positivity for ICAM-1, whereas the follicular carcinomas, follicular adenomas, and all but one nodular goiters were negative. It is suggested that the occurrence of ICAM-1 on the thyroid cell surfaces in well-differentiated papillary thyroid carcinomas may contribute to the understanding of their biology and could be of potential significance for diagnostic purposes.
authors.affiliation: Institute of Histopathology and Pathologic Anatomy, University of Sassari, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Tanda
authors.forename: A
authors.initials: A
authors.lastname: Cossu
authors.forename: L
authors.initials: L
authors.lastname: Bosincu
authors.forename: A
authors.initials: A
authors.lastname: Manca
authors.forename: M
authors.initials: M
authors.lastname: Ibba
authors.forename: G
authors.initials: G
authors.lastname: Massarelli
mesh_terms: D002291:Carcinoma, Papillary / Q000737:chemistry / Q000276:immunology* / Q000473:pathology*; D002454:Cell Differentiation; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis / Q000276:immunology*; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000276:immunology* / Q000473:pathology*
chemical_list: D018799:Intercellular Adhesion Molecule-1