Oligonucleotide directed triple helix formation.
Oligonucleotide directed triple helix formation allows the sequence-specific recognition of the major groove of double-helical DNA. Recently synthesized base analogs and backbones, such as N3'-->P5' phosphoramidates, allow stable triplexes to be formed under physiological conditions. However, it remains a challenge to design new oligomers that would extend the range of recognition sequences (which are still limited to oligopurine-rich tracts). Oligonucleotide directed triple helix formation could be used to control biological processes such as transcription and replication. Three-stranded structures formed during recombination processes have been further characterized.
Sun
J S
JS
Laboratoire de Biophysique, Muséum National d'Histoire Naturelle, INSERM U201, Centre National de la Recherche Scientifique, URA481, Paris, France. biophy@mnhn.fr
Garestier
T
T
Hélène
C
C
D001482:Base Composition; D004247:DNA / Q000737:chemistry; D007700:Kinetics; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry; D011938:Rec A Recombinases / Q000737:chemistry / Q000235:genetics; D013816:Thermodynamics
C051802:triplex DNA; D012313:RNA; D004247:DNA; D011938:Rec A Recombinases