Eosinophils and basophilic cells in sputum and nasal smears taken from infants and young children during acute asthma.
To examine the increase in eosinophils and basophilic cells in the respiratory areas of infants and young children with asthma (n = 111), we analyzed the numbers of eosinophils and basophilic cells in sputum and nasal smears. The number of children with eosinophilia grades of 2+ or greater (> or = 11 cells/five fields in x1000 magnification) in sputum and nasal smears, respectively, in each age group was as follows: 33% and 21% under 1 year, 59% and 64% at 1 year, and 79-80% and 75-78% at 2-3 years. An increased infiltration of basophilic cells according to age was also observed. Infiltration of these cells began earlier than the appearance of IgE antibodies to mite in blood.
Nagayama
Y
Y
Department of Allergy and Respiratory Disease, Chiba Children's Hospital, Chiba City, Japan.
Odazima
Y
Y
Nakayama
S
S
Toba
T
T
Funabashi
S
S
D000208:Acute Disease; D001249:Asthma / Q000276:immunology* / Q000473:pathology; D001491:Basophils / Q000473:pathology*; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D002675:Child, Preschool; D004804:Eosinophils / Q000473:pathology*; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D017817:Nasal Lavage Fluid / Q000166:cytology*; D011852:Radioallergosorbent Test; D013183:Sputum / Q000166:cytology*