Neurotransmitter receptors in the developing cerebral cortex.
This review deals with several aspects of neurotransmitter receptor development in the primate cerebral cortex. It describes the presence of multiple neurotransmitter receptors in the transient zones of the fetal cerebral wall. These zones are involved in the production and migration of cortical neurons and the establishment of appropriate innervation of the cortex. It also suggests functions that neurotransmitter receptors may perform in these embryonic zones. In addition, this review shows that a remarkable diversity of neurotransmitter receptors develops concurrently in disparate areas of the primate cerebral cortex and discusses the implications of this finding on our understanding of the general principles underlying development of the cerebral cortical circuitry. Finally, it speculates on factors that may be involved in regulation of neurotransmitter receptor development in the primate cerebral cortex.
Lidow
M S
MS
Yale University School of Medicine, Section of Neurobiology, New Haven, CT 06510, USA.
Wang
F
F
D000818:Animals; D002540:Cerebral Cortex / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism*; D006801:Humans; D017981:Receptors, Neurotransmitter / Q000378:metabolism*
D017981:Receptors, Neurotransmitter