title: Synergism of Ce (IV) and Pr(III) for the fastest non-enzymatic DNA hydrolysis ever.
abstract: By the synergistic catalysis of Ce4+ and Pr3+, DNA is efficiently hydrolyzed at so far the highest rate. When [Ce4+] = 10 mM and [Pr3+] = 5 mM, the half-life of dinucleotide hydrolysis at pH 7 and 50 degrees C is only 24 min. This catalytic activity is 9 times as large as that of Ce4+, which is the only prominent catalyst hitherto reported. The Ce(4+)-Nd3+ combination is also effective. These bimetallic catalytic systems are eminent tools for the future molecular biology and biotechnology.
authors.affiliation: Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Takeda
authors.forename: M
authors.initials: M
authors.lastname: Irisawa
authors.forename: T
authors.initials: T
authors.lastname: Imai
authors.forename: M
authors.initials: M
authors.lastname: Yashiro
authors.forename: M
authors.initials: M
authors.lastname: Komiyama
mesh_terms: D002384:Catalysis; D002563:Cerium; D004247:DNA / Q000737:chemistry*; D015226:Dinucleoside Phosphates / Q000737:chemistry; D004357:Drug Synergism; D006868:Hydrolysis; D007202:Indicators and Reagents; D007700:Kinetics; D009354:Neodymium; D011221:Praseodymium
chemical_list: D015226:Dinucleoside Phosphates; D007202:Indicators and Reagents; C017758:thymidylyl-(3'-5')-thymidine; D009354:Neodymium; D002563:Cerium; D004247:DNA; D011221:Praseodymium