[Bone marrow transplantation from an unrelated donor in patient with congenital heart diseases].
A 9-year-old with chronic myelogenous leukemia (CML) who received bone marrow transplantation from an unrelated donor (UBMT), is reported. He also suffered from congenital heart disease (CHD) consisting of corrected transposition of the great arteries and dextrocardia. The cardiac output was within normal limits. The conditioning regimen included busulfan, melphalan, ALG and TLI. Cyclophosphamide was not used because of it cardiotoxicity. The HLA-phenotype of the donor was identical with that of the patient. DNA typing showed was haplodentical DRB1. The patient is alive 18 months after the UBMT. This case showed that UBMT was possible in a CML patient with CHD, without congestive heart failure.
Kumazaki
H
H
Saitama Children's Medical Center.
Hanada
R
R
Kikuchi
A
A
Ichikawa
M
M
Yamamoto
K
K
Aoyagi
H
H
D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D006086:Graft vs Host Disease / Q000517:prevention & control; D006330:Heart Defects, Congenital / Q000150:complications*; D006650:Histocompatibility Testing; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000628:therapy*; D008297:Male; D010641:Phenotype; D014019:Tissue Donors
D007166:Immunosuppressive Agents