[Genetic analysis of bronchial asthma in Japanese population--Fc epsilon RI beta gene and beta 2 adrenergic receptor gene].
Atopy and bronchial hyperresponsiveness are important elements for the development of bronchial asthma. On the basis of the progression of molecular biology, the genetic regulations of asthma are being examined extensively and, recently, the gene encoding a beta subunit of the high affinity receptor for IgE (Fc epsilon RI beta) and the gene encoding beta 2 adrenergic receptor (beta 2ADR) are considered to be responsible for asthma. The mutation in the Fc epsilon RI beta gene on chromosome 11q13 is reported to be associated with atopy in British families with maternal inheritance of atopy. However there is no such an association between atopy and 11q13 in Japanese families. The polymorphisms in the beta 2 adrenergic receptor gene are reported to be related to the degree of agonist promoted downregulation of the receptor, and these polymorphisms are found to affect the severity of asthma. There is also evidence which supports a relationship between the polymorphism of the receptor and airway hyperresponsiveness in Japanese families.
Hizawa
N
N
First Department of Medicine, Hokkaido University.
Ohe
M
M
Kawakami
Y
Y
D044466:Asian People / Q000235:genetics*; D001249:Asthma / Q000235:genetics*; D006801:Humans; D007564:Japan; D011943:Receptors, Adrenergic, beta / Q000235:genetics*; D017455:Receptors, IgE / Q000235:genetics*
D011943:Receptors, Adrenergic, beta; D017455:Receptors, IgE