title: A controlled study of the effect of balanced general anaesthesia on cognitive functions in hypertensives on propranolol.
abstract: The aim of this study was to observe the effect of general anaesthesia (GA) on multiple dimensions of cognitive functioning in hypertensives on propranolol therapy (group A) in comparison to a control group (group B). Ten subjects in each group were administered a battery of six psychological cognitive tests pre- and post-intervention under GA. Both groups showed a significant decrement in memory scores on the 4th postoperative day which showed signs of recovery on seventh day (P < 0.05 for both groups). The group A patients were further compromised in one of the intelligence test scores (Standard progressive matrices) from the beginning (P < 0.05). Although this intergroup deficit persisted even on the 7th postoperative day (P < 0.05), no added effects of GA on this parameter was observed in group A (P > 0.05). In conclusion, GA induced transient memory deficit in both groups. This should be kept in mind while considering 'street fitness' following general anaesthesia.
authors.affiliation: Department of Anaesthesia, Postgraduate Institute of Medical Education & Research, Chandigarh.
authors.forename: S
authors.initials: S
authors.lastname: Sharma
authors.forename: S
authors.initials: S
authors.lastname: Mitra
authors.forename: D
authors.initials: D
authors.lastname: Arora
authors.forename: D
authors.initials: D
authors.lastname: Pershad
authors.forename: H
authors.initials: H
authors.lastname: Singh
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D003071:Cognition; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000523:psychology; D008297:Male; D011433:Propranolol / Q000627:therapeutic use*; D012016:Reference Values
chemical_list: D011433:Propranolol