Distribution of the HLA-DQA1 polymorphism in the population of the Basque Country (Spain).
Allele and genotype frequencies at the HLA-DQA1 locus were determined in Basque Country populations using PCR methodology and a dot-blot assay with ASO probes. The results showed no deviation from the Hardy-Weinberg equilibrium. No differences were found between the three Basque Provinces, but gene frequencies were significantly different from those of some other Spanish and world populations.
Esparza
B
B
Facultad de Medicina y Odontología, Universidad del País Vasco, Leioa, Vizcaya, Spain.
Pestoni
C
C
Martin
M D
MD
Merino
F
F
Carracedo
A
A
D000483:Alleles; D001483:Base Sequence; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D006801:Humans; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D013030:Spain / Q000453:epidemiology
D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen