title: Double-blind comparison of zopiclone and flunitrazepam in elderly insomniacs with special focus on residual effects.
abstract: In a double-blind study of 102 patients with a mean age of 79 years, zopiclone was compared to flunitrazepam. The patients rated their sleep in a diary. There was no statistically significant difference between the relatively low dose of 5 mg zopiclone and 1 mg flunitrazepam for eleven out of the twelve variables measuring subjective sleep quality and quantity. There was no differences between the drugs as regards patients' feelings of being rested or alertness.
authors.affiliation: Department of Internal Medicine, University Hospital, Lund, Sweden.
authors.forename: O
authors.initials: O
authors.lastname: Dehlin
authors.forename: B
authors.initials: B
authors.lastname: Rubin
authors.forename: A
authors.initials: A
authors.lastname: Rundgren
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D053961:Azabicyclo Compounds; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005445:Flunitrazepam / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000009:adverse effects* / Q000627:therapeutic use; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*; D016896:Treatment Outcome; D014851:Wakefulness / Q000187:drug effects
chemical_list: D053961:Azabicyclo Compounds; D006993:Hypnotics and Sedatives; D010879:Piperazines; C515050:zopiclone; D005445:Flunitrazepam