title: Patients with polycystic kidney disease would benefit from routine magnetic resonance angiographic screening for intracerebral aneurysms: a decision analysis.
abstract: Autosomal dominant polycystic kidney disease (ADPKD) is associated with increased prevalence of cerebral aneurysms and increased risk of subarachnoid hemorrhage. A decision analysis by Levey et al. in 1983 demonstrated that patients with ADPKD would not significantly benefit from routine arteriographic screening for cerebral aneurysms. We reexamined this conclusion in light of new clinical data and the introduction of magnetic resonance imaging (MRI) as a screening method. We compared an MRI screening strategy with a nonscreening strategy. The screening strategy specified MRI screening and then neurosurgical management of detected aneurysms. The nonscreening strategy specified cerebrovascular care only in the event of subarachnoid hemorrhage. The decision tree incorporated estimates derived from the clinical literature for the prevalence of asymptomatic aneurysms in patients with ADPKD (15%), the annual incidence of aneurysmal rupture (1.6%), the morbidity and mortality rates associated with subarachnoid hemorrhage (70 and 56%, respectively), the risk of transfemoral arteriography (0.2%), the sensitivity and specificity of MRI, the morbidity and mortality rates associated with surgical treatment of an unruptured aneurysm (4.1 and 1.0%, respectively), and the life expectancy of patients with ADPKD. The model predicted that the screening strategy would provide 1.0 additional year of life without neurological disability to a 20-year-old patient with ADPKD. A sensitivity analysis showed that the model was most sensitive to estimates of the prevalence of aneurysms in ADPKD, the annual incidence of rupture, and the morbidity and mortality rates associated with rupture. A financial analysis showed that a screening strategy is likely to cost less than a nonscreening strategy. The model predicts that an MRI screening strategy would increase the life expectancy of young patients with ADPKD and reduce the financial impact on society of ADPKD.
authors.affiliation: Neurosurgical Service, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: W E
authors.initials: WE
authors.lastname: Butler
authors.forename: F G
authors.initials: FG
authors.lastname: Barker
authors.forename: R M
authors.initials: RM
authors.lastname: Crowell
mesh_terms: D000328:Adult; D017542:Aneurysm, Ruptured / Q000175:diagnosis / Q000235:genetics / Q000401:mortality; D002423:Cause of Death; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D003362:Cost-Benefit Analysis; D003663:Decision Trees; D006233:Persons with Disabilities; D005799:Genes, Dominant / Q000235:genetics*; D006801:Humans; D002532:Intracranial Aneurysm / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality; D008017:Life Expectancy; D018810:Magnetic Resonance Angiography / Q000191:economics; D008390:Markov Chains; D007690:Polycystic Kidney Diseases / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality; D012306:Risk; D013345:Subarachnoid Hemorrhage / Q000175:diagnosis / Q000235:genetics / Q000401:mortality; D015996:Survival Rate