World distribution of HLA alleles and implications for disease.
The high level of polymorphism of the HLA system makes it useful for the study of diversity in different populations. However, its relationships with disease susceptibility, resistance and progression impose selective pressure on population frequencies that must be taken into consideration. These relationships allow useful studies on the genetic susceptibility to disease, which can be studied further and may provide us with another tool with which to examine the history of populations.
Bodmer
J
J
Imperial Cancer Research Fund, London, UK.
D000483:Alleles; D004194:Disease; D005787:Gene Frequency; D014943:Global Health; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D011153:Population; D014612:Vaccines
D006680:HLA Antigens; D014612:Vaccines