title: Microbiologic and economic evaluation of multiday infusion pumps for control of cancer pain.
abstract: OBJECTIVE
  To confirm established methods and assess bacteriologic and economic consequences for using external portable infusion pumps for the control of cancer pain in the home environment.
  
  
  METHODS
  Sixteen patients with terminal cancer were treated subcutaneously or epidurally with continuous infusions of morphine using external multiday infusion pumps. Bacterial growth in the pumps and costs linked to use in a hospital or at home were assessed. Patients treats at home received 2 pumps weekly, marked A for first use and B for second use, patients treated in the hospital received 1 pump every fourth day. After use, the remaining solution in the reservoirs was examined for microbiologic contents.
  
  
  RESULTS
  A total of 317 pumps was used and 211 pumps were cultured (66.6%). Growth was found in 16 (7.6%) (Staphylococcus albus in 13, Escherichia coli 2, and Candida albicans in 1 pump). There were no significant differences in contamination between pumps used in the hospital or A or B pumps used at home. No patient showed any signs of clinical infection associated with the infusions. The use multiday devices led to overall cost savings of $284,553 (2.1 million SKr) and a maximum cost savings potential of $379,404 (2.8 million SKr).
  
  
  CONCLUSIONS
  The multiday pump system used and the methods established were found to be safe and bacteriologically satisfactory, as well as cost-effective for both hospital and home use.
authors.affiliation: Department of Anaesthesia, Central Hospital, Kristianstad, Sweden.
authors.forename: L J
authors.initials: LJ
authors.lastname: Ohlsson
authors.forename: T S
authors.initials: TS
authors.lastname: Rydberg
authors.forename: T
authors.initials: T
authors.lastname: Edén
authors.forename: B A
authors.initials: BA
authors.lastname: Glimhall
authors.forename: L A
authors.initials: LA
authors.lastname: Thulin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use*; D002176:Candida albicans / Q000302:isolation & purification; D004866:Equipment Contamination / Q000191:economics*; D004926:Escherichia coli / Q000302:isolation & purification; D005069:Evaluation Studies as Topic; D005260:Female; D006699:Home Care Services; D006760:Hospitalization / Q000191:economics; D006801:Humans; D007260:Infusion Pumps / Q000191:economics*; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000627:therapeutic use*; D009369:Neoplasms / Q000503:physiopathology*; D010146:Pain / Q000188:drug therapy*; D013210:Staphylococcus / Q000302:isolation & purification; D013997:Time Factors
chemical_list: D000701:Analgesics, Opioid; D009020:Morphine