title: Isolation and identification of compounds from Brazilian propolis which enhance macrophage spreading and mobility.
abstract: Brazilian propolis is known to induce the activation of murine effector cells. We isolated and identified six compounds from a water-soluble extract of Brazilian propolis, all of which have enhancing effects on the spreading and mobility of murine macrophages. These compounds were identified as caffeoylquinic acid-derivatives, namely, 5-caffeoylquinic acid (1), chlorogenic acid (2), 4-caffeoylquinic acid (3), 4,5-dicaffeoylquinic acid (4), 3,5-dicaffeoylquinic acid (5) and 3,4-dicaffeoylquinic acid (6).
authors.affiliation: Hayashibara Biochemical Laboratories, Inc., Okayama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tatefuji
authors.forename: N
authors.initials: N
authors.lastname: Izumi
authors.forename: T
authors.initials: T
authors.lastname: Ohta
authors.forename: S
authors.initials: S
authors.lastname: Arai
authors.forename: M
authors.initials: M
authors.lastname: Ikeda
authors.forename: M
authors.initials: M
authors.lastname: Kurimoto
mesh_terms: D000818:Animals; D001938:Brazil; D002465:Cell Movement / Q000187:drug effects; D002630:Chemotactic Factors / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D066298:In Vitro Techniques; D017737:Macrophages, Peritoneal / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008815:Mice, Inbred Strains; D011429:Propolis / Q000737:chemistry / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013268:Stimulation, Chemical
chemical_list: D002630:Chemotactic Factors; D011429:Propolis