Effects of monoclonal anticardiolipin antibody on pregnant mice.
OBJECTIVE
To clarify the effects of anticardiolipin antibodies (aCL) on pregnancy.


METHODS
Monoclonal aCL obtained from MRL/lpr mice was administered to pregnant BALB/c mice and changes in the outcome of pregnancy were evaluated.


RESULTS
The pregnant BALB/c mice injected with monoclonal aCL showed a higher intrauterine fetal death rate than controls, but there were no significant differences in platelet counts. We observed signs of placental infarction only in the placenta of the treated pregnant BALB/c mice.


CONCLUSIONS
The intrauterine fetal deaths may have been due to thrombosis.
Suzuki
T
T
Second Department of Internal Medicine, Chiba University School of Medicine, Japan.
Takabayashi
K
K
Ichikawa
K
K
Itou
I
I
Ishiguro
N
N
Yoshiki
T
T
Koike
T
T
D000818:Animals; D017153:Antibodies, Anticardiolipin / Q000276:immunology / Q000494:pharmacology*; D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000494:pharmacology*; D001808:Blood Vessels / Q000473:pathology; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D009336:Necrosis; D010976:Platelet Count / Q000187:drug effects; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects* / Q000276:immunology; D013927:Thrombosis / Q000209:etiology
D017153:Antibodies, Anticardiolipin; D000911:Antibodies, Monoclonal