Non-major histocompatibility complex antigen class I-regulatory molecule for cytotoxicity by natural killer cells.
The mechanism of the cytotoxicity by natural killer (NK) cells is not known. It is speculated that there exist several positively regulated and negatively regulated target molecules expressed on the target cell surface. Although one of the latter is considered to be major histocompatibility complex antigen (MHC) class I, in this study we described a novel non-MHC class I molecule that may negatively regulate the NK cytotoxicity. This antigen is defined by monoclonal antibody Cho-1 and is composed of noncovalently associated antigens that are 40 and 200 kilodaltons in molecular size. The expression of this antigen is reduced along with the cell growth induced by growth factors and/or oncogenes. Thus, Cho-1-defined antigen appears to be involved as one of the resistant molecules in the cytotoxic mechanism of NK cells.
Kamiguchi
K
K
Department of Pathology, Sapporo Medical University, School of Medicine, Japan.
Takashima
S
S
Tamura
Y
Y
Cho
J M
JM
Torigoe
T
T
Takahashi
S
S
Sato
N
N
Kikuchi
K
K
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000235:genetics / Q000276:immunology; D002455:Cell Division / Q000187:drug effects / Q000276:immunology; D004591:Electrophoresis, Polyacrylamide Gel; D005347:Fibroblasts / Q000166:cytology* / Q000276:immunology; D005434:Flow Cytometry; D005786:Gene Expression Regulation / Q000235:genetics / Q000276:immunology; D005805:Genes, MHC Class I / Q000276:immunology*; D006133:Growth Substances / Q000633:toxicity; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology*; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000276:immunology*; D008970:Molecular Weight; D015513:Oncogene Proteins / Q000633:toxicity; D051381:Rats
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D006133:Growth Substances; D008869:Microtubule-Associated Proteins; D015513:Oncogene Proteins