title: NMR analysis of the backbone structure of DNA oligomers containing (5R)-/(5S)-[5'-2H]-2'-deoxynucleosides.
abstract: In order to distinguish between NMR signals for pro-R and pro-S protons of the 5'-methylene group, DNA oligomers containing [5'-2H]-2'-deoxynucleosides were synthesized. As the deuterium labeled nucleosides were mixtures of [(5'S)-2H]- and [(5'R)-2H]-isotopomers approximately in a ratio of 2:1, the signals du to pro-R and pro-S protons were assigned undoubt-edly.
authors.affiliation: Department of Chemistry, Faculty of Science, Tokyo Metropolitan University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Ono
authors.forename: Y
authors.initials: Y
authors.lastname: Kubo
authors.forename: T
authors.initials: T
authors.lastname: Makita
authors.forename: S
authors.initials: S
authors.lastname: Tate
authors.forename: E
authors.initials: E
authors.lastname: Kawashima
authors.forename: Y
authors.initials: Y
authors.lastname: Ishido
authors.forename: M
authors.initials: M
authors.lastname: Kainosho
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D003853:Deoxyribonucleosides / Q000737:chemistry; D003903:Deuterium / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism; D013936:Thymidine / Q000737:chemistry
chemical_list: D003853:Deoxyribonucleosides; D009838:Oligodeoxyribonucleotides; D004247:DNA; D003903:Deuterium; D013936:Thymidine