Chlamydia trachomatis as a possible cofactor for Kaposi's sarcoma in AIDS.
AIDS-associated Kaposi's sarcoma (KS) is much more frequent in patients acquiring HIV infection via the sexual route. Epidemiological studies have confirmed the likely involvement of a sexually acquired cofactor in the pathogenesis of this form of KS. We have formulated a set of postulates, epidemiological and experimental, to fit a single unifying hypothetical agent. Chlamydia trachomatis is one of 3 agents to fit the epidemiological criteria. Our data suggest a possible association between increased IgG serum antibody to C. trachomatis and the occurrence of KS. Conversely, higher titres of IgG serum antibody to C. pneumoniae were associated with the absence of KS. We feel that it is important to study further the relationship between C. trachomatis and KS.
Peters
B S
BS
Department of Genitourinary Medicine and Communicable Diseases, St Mary's Hospital Medical School, London, UK.
Thomas
B J
BJ
Yi
C
C
Beck
E J
EJ
Weber
J
J
Pinching
A J
AJ
Taylor-Robinson
D
D
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000473:pathology; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D002690:Chlamydia Infections / Q000150:complications* / Q000276:immunology; D002692:Chlamydia trachomatis / Q000276:immunology / Q000472:pathogenicity; D016993:Chlamydophila pneumoniae / Q000276:immunology; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D012514:Sarcoma, Kaposi / Q000150:complications* / Q000209:etiology*; D012725:Sexual Behavior
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G