title: Activity of glycylcyclines CL 329998 and CL 331002 against minocycline-resistant and other strains of methicillin-resistant Staphylococcus aureus.
abstract: Two glycylcyclines have been tested against 191 strains of methicillin-resistant Staphylococcus aureus, 72 of which were resistant to minocycline, isolated from many parts of the world. MICs of CL 329998 ranged from 0.06 to 4 mg/L, with MIC50 and MIC90 0.5 and 2 mg/L, respectively. CL 331002 was slightly less potent, having an MIC range 0.12-16 mg/L and MIC50 and MIC90 values of 1 and 4 mg/L, respectively.
authors.affiliation: Department of Medical Microbiology, Royal Free Hospital School of Medicine, London, UK.
authors.forename: J M
authors.initials: JM
authors.lastname: Hamilton-Miller
authors.forename: S
authors.initials: S
authors.lastname: Shah
mesh_terms: D000569:Americas; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001208:Asia; D001426:Bacterial Proteins / Q000235:genetics; D005060:Europe; D008565:Membrane Proteins / Q000235:genetics; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology*; D010641:Phenotype; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics; D013753:Tetracycline Resistance / Q000235:genetics; D013754:Tetracyclines / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D008565:Membrane Proteins; C083138:Tet M resistance protein, Bacteria; D013754:Tetracyclines; C084212:tet(K) protein, Staphylococcus aureus; C087533:CL 331002; C087532:N,N-dimethylglycylamidominocycline; D008911:Minocycline