title: Localization of two X-linked mental retardation (XLMR) genes to Xp: MRX37 gene at Xp22.31-p22.32 and a putative MRX gene on Xp22.11-p22.2.
abstract: MRX genes of 2 families with X-linked mental retardation (XLMR) were localized by linkage analysis. In family A, the gene was mapped to Xp22.31-p22.32, with significant LOD scores to various Xp22 markers within a distance of 6 Mb between DXS1223 and DXS1224. The MRX gene of this family was designated MRX37. In a mentally retarded female who is a carrier of the MRX37 gene, a random pattern of X inactivation was demonstrated. In family B, a positive LOD score, although not significant (< + 2), was found with the marker DXS1202 at Xp22.11-p22.2.
authors.affiliation: Department of Human Genetics, Hadassah Hebrew University Hospital, Jerusalem, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Bar-David
authors.forename: I
authors.initials: I
authors.lastname: Lerer
authors.forename: C K
authors.initials: CK
authors.lastname: Sarfaty
authors.forename: Z G
authors.initials: ZG
authors.lastname: Kohan
authors.forename: V
authors.initials: V
authors.lastname: Meiner
authors.forename: J
authors.initials: J
authors.lastname: Zlotogora
authors.forename: D
authors.initials: D
authors.lastname: Abeliovich
mesh_terms: D002874:Chromosome Mapping; D004303:Dosage Compensation, Genetic; D005260:Female; D006580:Genetic Carrier Screening; D008040:Genetic Linkage; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D008126:Lod Score; D008297:Male; D010375:Pedigree; D014960:X Chromosome