Vasodilator effect of human adrenomedullin(13-52) on hypertensive rats.
Human adrenomedullin (hADM) is a newly isolated peptide with hypotensive activity in normotensive rats. The objective of this study was to investigate the effect of hADM(13-52) on hypertensive animals. hADM(13-52) induced a dose-dependent decrease in the blood pressure of spontaneously hypertensive rats and renal hypertensive rats. This result suggests that hADM is a novel antihypertensive peptide. In isolated rat aortic arteries, hADM(13-52) produced nitric oxide dependent relaxation and inhibited endothelin 1 and angiotensin II release. These in vitro effects may represent the molecular mechanisms underlying the hypotensive action of hADM in vivo.
Tian
Q
Q
J.K. Chang Peptide Research Laboratory, Beijing Medical University, People's Republic of China.
Zhao
D
D
Tan
D Y
DY
Zhao
Y T
YT
Li
Q H
QH
Qiu
J X
JX
Song
L W
LW
Gong
C N
CN
Yang
J
J
Lippton
H
H
D053607:Adrenomedullin; D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D016232:Endothelins / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D009569:Nitric Oxide / Q000502:physiology; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000494:pharmacology*
D000959:Antihypertensive Agents; D016232:Endothelins; D010446:Peptide Fragments; D014665:Vasodilator Agents; C094546:adrenomedullin (13-52); D000804:Angiotensin II; D053607:Adrenomedullin; D009569:Nitric Oxide