Glutamate receptor subtypes localize to patches in the developing striatum.
The distribution of glutamate receptors in the developing striatum of the rat was studied using antibodies specific to AMPA and NMDA subtypes. Immunocytochemistry revealed a greater density of GluR1, GluR2/3, NMDAR1, and NMDAR2A/2B receptors in patches that matched the patches of substance P-immunoreactive neurons and dopaminergic terminals. GluR1-immunoreactive patches were the most distinctive and were present already at embryonic day 19.
Snyder-Keller
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Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201, USA. snykell@wadsworth.org
Costantini
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LC
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D003342:Corpus Striatum / Q000737:chemistry* / Q000196:embryology; D005314:Embryonic and Fetal Development / Q000502:physiology; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA / Q000032:analysis*; D016194:Receptors, N-Methyl-D-Aspartate / Q000032:analysis*
D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate