title: Acromegalic pregnancy associated with a Beckwith-Wiedemann fetus.
abstract: BACKGROUND
  Beckwith-Wiedemann syndrome is a rare serious condition with a high rate of malignant tumors. A relationship between Beckwith-Wiedemann syndrome and insulin-like growth factor (IGF) II gene located at the level of the 11p15 chromosomic region has been demonstrated.
  
  
  METHODS
  An acromegalic woman (elevated IGF I serum levels) undergoing pregnancy with a Beckwith-Wiedemann fetus is reported. We therefore reviewed data about this association and particularly fetal growth, and analyzed fetal blood samples for IGF I and II.
  
  
  CONCLUSIONS
  We conclude that this association (i.e. Beckwith-Wiedemann syndrome and acromegaly) is independent, and point out that IGF I and II might be very high in the Beckwith-Wiedemann fetus.
authors.affiliation: Maternité de l'Hôpital Robert-Debré, Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Luton
authors.forename: J
authors.initials: J
authors.lastname: Lepercq
authors.forename: O
authors.initials: O
authors.lastname: Sibony
authors.forename: P
authors.initials: P
authors.lastname: Barbet
authors.forename: Y
authors.initials: Y
authors.lastname: Le Bouc
authors.forename: J
authors.initials: J
authors.lastname: Chavinié
authors.forename: F
authors.initials: F
authors.lastname: Lewin
mesh_terms: D000172:Acromegaly / Q000097:blood*; D000328:Adult; D001506:Beckwith-Wiedemann Syndrome / Q000235:genetics*; D005260:Female; D005315:Fetal Diseases / Q000235:genetics; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007335:Insulin-Like Growth Factor II / Q000235:genetics; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood
chemical_list: D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II