title: Prescriptions for mesalazine and sulphasalazine: a prevalence estimate of patients treated for inflammatory bowel disease in Rome.
abstract: BACKGROUND
  Sulphasalazine and 5-amino salicyclic acid drugs are specifically indicated for the treatment of inflammatory bowel disease.
  
  
  OBJECTIVE
  To use drug consumption by a given population as a marker to estimate the number of patients with inflammatory bowel disease.
  
  
  METHODS
  Prescriptions for sulphasalazine and mesalazine were identified for the 133000 inhabitants of a local health unit in Rome. Other prescriptions received by the patients, who were users of sulphasalazine or mesalazine, were also studied.
  
  
  RESULTS
  99465 patients received at least one prescription for any drug in 1991. Three hundred and seventy-six patients were prescribed sulphasalazine and/or mesalazine, an average of 3.8 prescriptions per patient. These patients were exposed more frequently than the general population to other drugs often used in inflammatory bowel disease treatment, for example, corticosteroids, anti-diarrhoeal drugs and intestinal anti-infectives. We identified that 258 of 100000 inhabitants were prescribed either sulphasalazine or mesalazine; 127 of 100000 inhabitants received full-dose treatment for at least 30 days, and 42.8 of 100000 inhabitants received prescriptions of either drug, also associated with systemic corticosteroids.
  
  
  CONCLUSIONS
  The consumption of drugs used specifically for inflammatory bowel disease may act as a marker for the prevalence of the condition in a community.
authors.affiliation: Istituto Superiore di Sanità, Rome, Italy.
authors.forename: M T
authors.initials: MT
authors.lastname: Tebano
authors.forename: G
authors.initials: G
authors.lastname: Traversa
authors.forename: R
authors.initials: R
authors.lastname: Da Cas
authors.forename: A
authors.initials: A
authors.lastname: Loizzo
mesh_terms: D000636:Aminosalicylic Acids / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004363:Drug Utilization; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000453:epidemiology*; D007558:Italy / Q000453:epidemiology; D019804:Mesalamine; D015995:Prevalence; D012460:Sulfasalazine / Q000627:therapeutic use*
chemical_list: D000636:Aminosalicylic Acids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005765:Gastrointestinal Agents; D012460:Sulfasalazine; D019804:Mesalamine