Experimental and clinical studies on balloon laserthermia using Nd: YAG laser for uterine endometrial cancer.
OBJECTIVE
No conservative therapy for endometrial cancer exists. We therefore evaluated the new balloon laserthermia for such cases.


METHODS
Experimental and clinical study. We examined experimentally porcine kidney and stomach, human resected uterus and clinically on 12 patients with endometrial cancer and two patients with hyperplasia.


RESULTS
Temperatures were safely kept at the balloon surface. Laser irradiation should be performed for at least 10-15 min, 65-70 degrees C to produce a suitable degeneration, experimentally. Clinically, necrosis and degeneration to a depth of 4-6 mm was histologically observed. Eight patients with carcinoma and hyperplasia for which laserthermia was effective showed that the surface of cancer was smooth and the depth of invasion was in most cases up to 1/4 of muscle layer.


CONCLUSIONS
Balloon laserthermia may be effective in early endometrial cancer or precancerous lesions. Its clinical usefulness should be investigated further.
Ueki
M
M
Department of Obstetrics and Gynecology, Osaka Medical College, Japan.
Inoki
C
C
Ueda
M
M
Tsutsumi
A
A
Nakazato
M
M
Daikuzono
N
N
D000328:Adult; D000368:Aged; D000818:Animals; D004714:Endometrial Hyperplasia / Q000628:therapy; D016889:Endometrial Neoplasms / Q000473:pathology / Q000628:therapy*; D004717:Endometrium / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D007668:Kidney / Q000528:radiation effects; D053685:Laser Therapy; D008875:Middle Aged; D013270:Stomach / Q000528:radiation effects; D013552:Swine; D013696:Temperature; D014594:Uterine Neoplasms / Q000628:therapy*