title: [Rational hypertension treatment].
abstract: The primary objective of antihypertensive treatment is to prevent the involvement of target-organs, including hypertensive vascular disease of the kidney or left ventricular hypertrophy. Antihypertensive treatment should not worsen other cardiovascular risk factors (e.g. lipids) or impair quality of life. Contemporary efforts to optimize antihypertensive therapy are focused on single-drug therapy and on individualizing treatment according to patients age, sex, race and the presence of concomitant illnesses and therapies, in order to improve compliance and reduce overall cardiovascular morbidity and mortality. Several antihypertensive drugs such as ACE-inhibitors, beta-adrenergic-receptor antagonists, calcium channel blockers, diuretics, alpha-adrenergic-receptor antagonists, and newer substances such as imidazoline-receptor antagonists and angiotensin-II antagonists are discussed.
authors.affiliation: Medizinische Klinik, Kantonsspital Chur.
authors.forename: C R
authors.initials: CR
authors.lastname: Canova
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000804:Angiotensin II / Q000037:antagonists & inhibitors; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D006978:Hypertension, Renovascular / Q000517:prevention & control; D017379:Hypertrophy, Left Ventricular / Q000517:prevention & control; D007093:Imidazoles / Q000037:antagonists & inhibitors; D054755:Imidazoline Receptors; D008297:Male; D011955:Receptors, Drug / Q000037:antagonists & inhibitors; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D004232:Diuretics; D007093:Imidazoles; D054755:Imidazoline Receptors; D011955:Receptors, Drug; D014665:Vasodilator Agents; D000804:Angiotensin II