title: [Locoregional injection of OK-432/fibrinogen/thrombin for unresectable metastatic liver tumors].
abstract: We performed the locoregional injection of OK-432/fibrinogen/thrombin to unresectable hepatic tumors metastasized from colorectal cancers, which were hardly controlled by arterial infusion chemotherapy. CEA was markedly decreased following this treatment, although abdominal CT did not show a significant reduction of tumor mass. This immuno-injection therapy may be a choice of treatment for metastatic liver tumors, refractory to treatment by conventional chemotherapy.
authors.affiliation: Dept. of Surgery II, Osaka University Medical School.
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
authors.forename: H
authors.initials: H
authors.lastname: Osato
authors.forename: M
authors.initials: M
authors.lastname: Sakon
authors.forename: T
authors.initials: T
authors.lastname: Monden
authors.forename: M
authors.initials: M
authors.lastname: Amano
authors.forename: T
authors.initials: T
authors.lastname: Aoki
authors.forename: S
authors.initials: S
authors.lastname: Kishimoto
authors.forename: K
authors.initials: K
authors.lastname: Umeshita
authors.forename: K
authors.initials: K
authors.lastname: Dono
authors.forename: M
authors.initials: M
authors.lastname: Gotoh
authors.forename: M
authors.initials: M
authors.lastname: Monden
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002272:Carcinoembryonic Antigen / Q000097:blood; D015179:Colorectal Neoplasms / Q000473:pathology; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005340:Fibrinogen / Q000008:administration & dosage*; D006801:Humans; D015552:Injections, Intralesional; D008113:Liver Neoplasms / Q000276:immunology / Q000556:secondary / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010844:Picibanil / Q000008:administration & dosage*; D013917:Thrombin / Q000008:administration & dosage*
chemical_list: D000970:Antineoplastic Agents; D002272:Carcinoembryonic Antigen; D010844:Picibanil; D005340:Fibrinogen; D013917:Thrombin