title: MRI in characterization of focal liver lesions: comparison of T2 weighting by conventional spin-echo and turbo spin-echo sequences.
abstract: Forty-one patients with 61 proved focal liver lesions underwent MRI of the liver at 1.0 T, with the aim of evaluating the usefulness of turbo spin-echo (TSE) sequences in characterizing focal liver lesions, by comparing them with conventional spin-echo (CSE) sequences. Two different TSE protocols were employed. with constant echo time and varying repetition time: TSE-S (3000 msec) and TSE-L (5100 msec). All images were evaluated quantitatively (signal-to-noise ration 'SNR') and qualitatively: because benign lesions were all liquid (12 cysts and 10 hemangiomas), they were well characterized morphologically on the basis of signal intensity. Mean SNR was significantly different between metastases and benign lesions (P < .0001) with all T2 sequences. Among the single T2 sequences tested, logistic regression analysis showed TSE-L to have the best predictive ability of the nature of focal lesions, with a G value of 42.02, compared to 29.87 of TSE-S and 25.55 of CSE second echo (SE II). The combination of TSE-L with TSE-S did not modify these results, whereas the combination of TSE-L with CSE only resulted in slight improvement (G = 46.95). Comparison of the receiver operating characteristic (ROC) curves showed only SE II (area under the ROC curve of .8312) to be significantly inferior to the best single sequence, or TSE-L (area under the ROC curve of .9176; P = .027). All sequences were equivalent in qualitative evaluation with good reproducibility, sensitivity ranging from .94 to 1.0 and specificity ranging from .86 to .93. This study confirms the value of TSE sequences in characterization of focal liver lesions. Time of acquisition is strongly reduced with these sequences, whereas results are fairly similar to those obtained with CSE. TSE sequences could therefore replace CSE for the study of focal liver lesions.
authors.affiliation: Department of Radiology, University of Ancona, NMR Center Angelini, Ospedale Torrette, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Giovagnoni
authors.forename: E
authors.initials: E
authors.lastname: Paci
authors.forename: G
authors.initials: G
authors.lastname: Valeri
authors.forename: P
authors.initials: P
authors.lastname: Ercolani
authors.forename: R
authors.initials: R
authors.lastname: Gesuita
authors.forename: F
authors.initials: F
authors.lastname: Carle
authors.forename: A
authors.initials: A
authors.lastname: Piga
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D016477:Artifacts; D003560:Cysts / Q000175:diagnosis; D005260:Female; D005544:Forecasting; D006391:Hemangioma / Q000175:diagnosis; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008107:Liver Diseases / Q000175:diagnosis*; D008113:Liver Neoplasms / Q000175:diagnosis / Q000556:secondary; D016015:Logistic Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012044:Regression Analysis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity