title: [Effects of amrinon and prostaglandin E1 on intraoperative central and peripheral temperatures during peripheral arterial surgery].
abstract: Effects of amrinon (AM) and prostaglandin E1 (PG) on body temperatures during surgery under general anesthesia were studied. Thirty-nine elective peripheral arterial surgery patients were assigned to one of three groups. All groups received dopamine (DOA) 3 micrograms.kg-1.min-1 after intubation and ten patients receiving only DOA served as a control group. Fifteen patients who received AM 1 microgram.kg-1 followed by AM 5 micrograms.kg-1.min-1 were assigned as an AM group. Fourteen patients who received PG 0.02 micrograms.kg-1.min-1 were defined as a PG group. Rectal and fingertip temperatures were monitored continuously during surgery. Fingertip temperatures in both AM and PG groups were significantly higher than those in the control group 120 minutes after the administration of drugs. On the other hand, rectal temperatures in all groups did not differ significantly throughout the study. The rectum-fingertip temperature gradient was lower in both AM and PG group than in the control group. These results suggest that bolus injection of AM 1 microgram.kg-1 followed by AM 5 micrograms.kg-1.min-1 and PG 0.02 micrograms.kg-1.min-1 may be effective for maintaining central and peripheral temperatures during surgery under general anesthesia.
authors.affiliation: Department of Anesthesiology, Yamanashi Medical University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Nonaka
authors.forename: S
authors.initials: S
authors.lastname: Kashimoto
authors.forename: T
authors.initials: T
authors.lastname: Matsukawa
authors.forename: T
authors.initials: T
authors.lastname: Kumazawa
mesh_terms: D000368:Aged; D000527:Alprostadil / Q000008:administration & dosage* / Q000494:pharmacology; D000676:Amrinone / Q000008:administration & dosage* / Q000494:pharmacology; D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D001157:Arterial Occlusive Diseases / Q000601:surgery; D001833:Body Temperature Regulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D014665:Vasodilator Agents; D000527:Alprostadil; D000676:Amrinone