title: Energy metabolism patterns in mammalian myocardium adapted to chronic physiopathological conditions.
abstract: OBJECTIVE
  When the myocardium is subjected to a chronic overload, it enlarges and a major restructuring of all organelles and cellular functions occurs. The changes occurring at the level of the contractile apparatus are well documented; less is known about the alterations in the energy status of the hypertrophied cardiomyocyte. The purpose of this paper is firstly to provide a brief review of the data published on this topic and secondly to analyse previously published data drawn from studies devoted to the evaluation of the capacity of the ATP-producing processes to respond to an acute change in workload.
  
  
  METHODS
  Several different chronic conditions were studied in rats: senescence, hypertension, chronic hypoxia, and administration of thyroid hormone. The pattern of the metabolic response of the heart to acute changes in workload was characterized by alterations in the concentrations of phosphocreatine, inorganic phosphate and ATP followed in isolated heart by 31P-NMR spectroscopy.
  
  
  RESULTS
  In most of the models studied the pattern of these changes was very similar to that observed in controls. The only exceptions concerned the hearts of young hypertensive rats and those of animals subjected to a cumulated overload (hypertension + thyroid hormone).
  
  
  CONCLUSIONS
  Our results demonstrate that the regulation of energy metabolism was well preserved in spite of the extensive restructuring that occurs in rat hearts subjected to different chronic conditions which could affect the energy balance of the cardiomyocyte.
authors.affiliation: Laboratoire de Physiologie Cellulaire Cardiaque, Universite Joseph Fourier, Grenoble, France.
authors.forename: A
authors.initials: A
authors.lastname: Rossi
authors.forename: S
authors.initials: S
authors.lastname: Lortet
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D006332:Cardiomegaly / Q000378:metabolism*; D002908:Chronic Disease; D004734:Energy Metabolism; D009206:Myocardium / Q000378:metabolism*; D051381:Rats
chemical_list: D000255:Adenosine Triphosphate