title: Biological fate of fumonisin B1 in food-producing animals.
abstract: The presence of mycotoxins in grains and feedstuffs causes not only animal health problems, but also a valid concern about the transmission of potentially toxic residues into animal-derived products intended for human consumption. In a series of studies at Agriculture and Agri-Food Canada, we investigated the biological fate of fumonisin B1 (FB1) in several food-producing animals (grower pigs, laying hens, dairy cattle), as well as monitored various parameters for evidence of toxicity in these species. In several experiments involving either single-dose protocols (iv, po) or longer-term feeding trials, the pharmacokinetic profiles of FB1 (purity > 95%) in these species were determined, including tissue accumulation and transmission of residues. Toxicological (and economical) implications such as performance (feed consumption, growth), productivity, and carcass quality were also measured when appropriate.
authors.affiliation: Centre for Food and Animal Research Agriculture and Agri-Food Canada, Ottawa, Ontario.
authors.forename: D B
authors.initials: DB
authors.lastname: Prelusky
authors.forename: H L
authors.initials: HL
authors.lastname: Trenholm
authors.forename: B A
authors.initials: BA
authors.lastname: Rotter
authors.forename: J D
authors.initials: JD
authors.lastname: Miller
authors.forename: M E
authors.initials: ME
authors.lastname: Savard
authors.forename: J M
authors.initials: JM
authors.lastname: Yeung
authors.forename: P M
authors.initials: PM
authors.lastname: Scott
mesh_terms: D000042:Absorption; D000821:Animal Feed; D000818:Animals; D001822:Body Burden; D002417:Cattle / Q000378:metabolism*; D002645:Chickens / Q000378:metabolism*; D004435:Eating; D005260:Female; D005506:Food Contamination; D037341:Fumonisins; D007700:Kinetics; D009183:Mycotoxins / Q000032:analysis / Q000493:pharmacokinetics*; D009928:Organ Specificity; D013552:Swine / Q000378:metabolism*; D015430:Weight Gain
chemical_list: D037341:Fumonisins; D009183:Mycotoxins; C056933:fumonisin B1