Oral fluconazole in the treatment of pulmonary cryptococcosis in non-AIDS patients.
Four non-AIDS patients with pulmonary cryptococcus infection who could not tolerate amphotericin B treatment were given oral fluconazole at a dose of 600 mg once daily for 4-5 weeks followed by 400 mg once daily for 10-12 weeks resulting in cure. All patients did not have relapse of disease when followed-up for 8-24 months after cessation of treatment. The very good tolerance of oral fluconazole by these patients suggests that such effective monotherapy should be evaluated further in non-AIDS patients with pulmonary cryptococcosis.
Yew
W W
WW
Tuberculosis and Chest Unit, Grantham Hospital, Hong Kong.
Wong
P C
PC
Wong
C F
CF
Lee
J
J
Chau
C H
CH
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D003453:Cryptococcosis / Q000188:drug therapy*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000188:drug therapy*; D008297:Male
D000935:Antifungal Agents; D015725:Fluconazole