title: Liver transplantation without the use of fresh frozen plasma.
abstract: In orthotopic liver transplantations (OLT), fresh frozen plasma (FFP) is classically used to normalize coagulation factor concentrations. In this study, 28 OLT were performed without the use of FFP. According to their preoperative factor V (FV) levels, two groups of patients were defined: Group 1 (13 patients, FV > 10% and < 60%) and Group 2 (15 patients, FV > 60%). Spontaneous evolution of coagulation factors, concentration, and bleeding were observed during OLT and up to 48 h after surgery. Total intraoperative bleeding was similar in both groups (3460 +/- 2700 mL and 3470 +/- 2110 mL in Groups 1 and 2, respectively). Levels of clotting factors were not different between groups after the anhepatic stage. The lowest values were noted after reperfusion. Thirty-six hours after surgery, all levels of clotting factors in both groups were more than 50%, with FV level increasing the most rapidly. Hematocrit from the subhepatic drainage liquid was 1.8% and less than 1% at 24 and 48 h, respectively, after surgery. No reintervention for bleeding was necessary. These results suggest that, in OLT, correct hemostasis can be assumed without FFP use when hyperfibrinolysis, platelet count, fibrinogen rate, and hemodynamic status are controlled.
authors.affiliation: Départment d'Anesthésie Réanimation Chirurgicale II CHRU, Lille, France.
authors.forename: J
authors.initials: J
authors.lastname: Dupont
authors.forename: F
authors.initials: F
authors.lastname: Messiant
authors.forename: N
authors.initials: N
authors.lastname: Declerck
authors.forename: B
authors.initials: B
authors.lastname: Tavernier
authors.forename: B
authors.initials: B
authors.lastname: Jude
authors.forename: L
authors.initials: L
authors.lastname: Durinck
authors.forename: F R
authors.initials: FR
authors.lastname: Pruvot
authors.forename: P
authors.initials: P
authors.lastname: Scherpereel
mesh_terms: D000328:Adult; D001779:Blood Coagulation Factors / Q000032:analysis; D016913:Blood Component Transfusion; D016063:Blood Loss, Surgical; D001803:Blood Transfusion; D001804:Blood Transfusion, Autologous; D004322:Drainage; D005165:Factor V / Q000032:analysis; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis; D005500:Follow-Up Studies; D006400:Hematocrit; D006488:Hemostasis, Surgical; D006801:Humans; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010949:Plasma; D010976:Platelet Count; D019106:Postoperative Hemorrhage / Q000517:prevention & control; D011446:Prospective Studies; D012086:Reoperation; D015424:Reperfusion
chemical_list: D001779:Blood Coagulation Factors; D005165:Factor V; D005340:Fibrinogen