Clozapine as a treatment for psychosis in Parkinson's disease: a review.
Psychotic symptoms such as visual hallucinations and delusions are a relatively common clinical problem in patients with Parkinson's disease (PD). A dilemma arises in the treatment of psychosis in these patients because traditional antipsychotics are dopaminergic antagonists that worsen the motor symptoms of PD. Clozapine, an atypical antipsychotic, has been successfully used in the treatment of psychosis in PD patients. The use of clozapine in these patients differs significantly, however, from its use in young, relatively healthy, treatment-resistant schizophrenic patients in the dosage required, side effects, and other aspects of management.
Musser
W S
WS
Department of Psychiatry, University of Pittsburgh Medical Center, Pennsylvania 15213, USA.
Akil
M
M
D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003024:Clozapine / Q000627:therapeutic use*; D003704:Dementia / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D010300:Parkinson Disease / Q000150:complications* / Q000523:psychology
D014150:Antipsychotic Agents; D003024:Clozapine