Galactosamine alters glucose regulation in ten-day-old rats treated with a low dose of endotoxin.
Hypoglycemia develops rapidly during septic shock and is a common and life-threatening problem in the human newborn. In adult animals, galactosamine alter glucose metabolism and increases mortality of endotoxic shock. Galactosamine may alter tissue glucose uptake and induce hypoglycemia in ten-day-old rats. The present study showed that galactosamine induced hypoglycemia and a high mortality without an increase in plasma insulin concentration in ten-day-old rats treated with a low dose of endotoxin. Galactosamine decreased tissue glucose uptake in endotoxin-treated animals. Hypoglycemia induced by galactosamine could be due to decreased gluconeogenesis.
Topaloglu
A K
AK
Children's Hospital at Loyola University of Chicago, Maywood, Illinois 60153, USA.
Goto
M
M
Ravindranath
T
T
Zeller
W P
WP
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001427:Bacterial Toxins / Q000633:toxicity*; D001786:Blood Glucose / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D004731:Endotoxins / Q000633:toxicity*; D004768:Enterotoxins / Q000633:toxicity*; D005260:Female; D005688:Galactosamine / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D007003:Hypoglycemia / Q000097:blood / Q000139:chemically induced; D007328:Insulin / Q000097:blood; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012477:Salmonella enteritidis / Q000378:metabolism*
D001427:Bacterial Toxins; D001786:Blood Glucose; D004731:Endotoxins; D004768:Enterotoxins; D007328:Insulin; D007773:Lactates; C027952:salmonella toxin; D019344:Lactic Acid; D005688:Galactosamine; D005947:Glucose