title: The role of Na+/H+ exchange in ischemia-reperfusion.
abstract: In ischemia the cytosol of cardiomyocytes acidifies; this is reversed upon reperfusion. One of the major pH(i)-regulating transport systems involved is the Na+/H+ exchanger. Inhibitors of the Na+/H+ exchanger have been found to more effectively protect ischemic-reperfused myocardium when administered before and during ischemia than during reperfusion alone. It has been hypothesized that the protection provided by pre-ischemic administration is due to a reduction in Na+ and secondary Ca2+ influx. Under reperfusion conditions Na+/H/ exchange inhibition also seems protective since it prolongs intracellular acidosis which can prevent hypercontracture. In detail, however, the mechanisms by which Na+/H+ exchange inhibition provides protection in ischemic-reperfused myocardium are still not fully identified.
authors.affiliation: Physiologisches Institut, Justus-Liebig-Universität, Giessen, FRG.
authors.forename: H M
authors.initials: HM
authors.lastname: Piper
authors.forename: C
authors.initials: C
authors.lastname: Balser
authors.forename: Y V
authors.initials: YV
authors.lastname: Ladilov
authors.forename: M
authors.initials: M
authors.lastname: Schäfer
authors.forename: B
authors.initials: B
authors.lastname: Siegmund
authors.forename: M
authors.initials: M
authors.lastname: Ruiz-Meana
authors.forename: D
authors.initials: D
authors.lastname: Garcia-Dorado
mesh_terms: D000138:Acidosis / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007424:Intracellular Fluid / Q000378:metabolism; D017202:Myocardial Ischemia / Q000503:physiopathology* / Q000517:prevention & control; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology* / Q000517:prevention & control; D015427:Reperfusion Injury / Q000503:physiopathology* / Q000517:prevention & control; D012964:Sodium / Q000378:metabolism; D017923:Sodium-Hydrogen Exchangers / Q000037:antagonists & inhibitors / Q000502:physiology*
chemical_list: D017923:Sodium-Hydrogen Exchangers; D012964:Sodium; D002118:Calcium