Temporal association between the use of methotrexate and development of leukemia in 2 patients with rheumatoid arthritis.
To date only a single case of leukemia coincident with the use of methotrexate (MTX) in rheumatoid arthritis (RA) has been reported. We report 2 additional patients with RA, each of whom developed leukemia after receiving short term low dose MTX. Whether these cases represent an adverse effect of MTX treatment has yet to be determined.
Dubin Kerr
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Department of Medicine, Mount Sinai Medical Center, New York, NY 10029, USA.
Troy
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Isola
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D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000139:chemically induced* / Q000150:complications*; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged; D013997:Time Factors
D008727:Methotrexate