Role of adenosine in blood flow in the rat intestine.
We examined the relation between adenosine production and increased blood flow. For this purpose, we used a sensor holding system with a laser Doppler blood flowmeter. The elevation of blood flow was observed by administration of adenosine. Therefore, when AMP was administered to the rats, the elevation of blood flow rate was observed. These results suggest that AMP is rapidly transported to the adenosine active site by ecto-5'-nucleotidase.
Obata
T
T
Department of Pharmacology, Oita Medical University, Japan.
Yamanaka
Y
Y
Hirata
T
T
Uchida
Y
Y
D015720:5'-Nucleotidase / Q000378:metabolism*; D000241:Adenosine / Q000502:physiology*; D000249:Adenosine Monophosphate / Q000494:pharmacology*; D000818:Animals; D007583:Jejunum / Q000098:blood supply; D017078:Laser-Doppler Flowmetry; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow
D000249:Adenosine Monophosphate; D015720:5'-Nucleotidase; D000241:Adenosine