[The central catecholaminergic mechanisms regulating thyroid function in birds].
Response of the hypothalamo-hypophyseal-thyroid system of birds to drugs influencing brain catecholaminergic structures was analyzed by means of radioimmunoassay and morphometry. The 12-day- and 60-day-old cockerels were given dopamine precursor (L-DOPA), dopamine-blocking agent (haloperidole) and alpha-adrenoceptor activator (phenylephrine) during 7 days. The results obtained demonstrate that the brain catecholaminergic structures have participated in regulation of the hypothalamo-hypophyseal-thyroid system of birds. The dopaminergic structures have inhibited, the thyroid function while, alpha-adrenergic structures have stimulated it.
Hordiienko
V M
VM
Paziuk
L M
LM
Dzerzhyns'kyĭ
M E
ME
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D002230:Carbidopa / Q000494:pharmacology; D002645:Chickens / Q000502:physiology*; D018491:Dopamine Agonists / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D004338:Drug Combinations; D006220:Haloperidol / Q000494:pharmacology; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000502:physiology; D007980:Levodopa / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D017983:Receptors, Catecholamine / Q000187:drug effects / Q000502:physiology*; D013961:Thyroid Gland / Q000187:drug effects / Q000502:physiology*
D000316:Adrenergic alpha-Agonists; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D004338:Drug Combinations; D017983:Receptors, Catecholamine; C009265:carbidopa, levodopa drug combination; D010656:Phenylephrine; D007980:Levodopa; D006220:Haloperidol; D002230:Carbidopa