Apo-E genotype and verbal deficits in Alzheimer's disease.
Apo-E genotype was not significantly related to cognitive performance in 157 Alzheimer's disease patients. However, patients homozygous for the epsilon 4 allele appeared most impaired on global cognition but least impaired on language measures. Further study with larger samples may reveal that Apo-E genotype accounts for some of the variability in cognitive deficits observed in Alzheimer's disease.
Rasmusson
D X
DX
Department of Psychiatry/Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. xeno@mvx.grc.nia.nih.gov
Dal Forno
G
G
Brandt
J
J
Warren
A C
AC
Troncoso
J
J
Lyketsos
C
C
D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics* / Q000523:psychology*; D001057:Apolipoproteins E / Q000235:genetics / Q000378:metabolism*; D003072:Cognition Disorders / Q000235:genetics* / Q000523:psychology*; D005260:Female; D005838:Genotype; D006801:Humans; D007806:Language Disorders / Q000235:genetics* / Q000523:psychology*; D007807:Language Tests; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests
D001057:Apolipoproteins E