Mechanism of action of cyclosporin in rheumatoid arthritis.
Heterogenous population of cells, including macrophages, synoviocytes and lymphocytes play important roles in the immunopathogenesis of rheumatoid arthritis (RA). T cells, however, seem to be a common thread throughout the disease process. In inhibiting T lymphocytes, cyclosporin A presents a more selective form of therapy in RA. The immunosuppressive action of cyclosporin is primarily due to the inhibition of antigen/mitogen-induced secretion of lymphokines at the transcriptional level from T cell. The inhibition of Ca2(+)-dependent signaling pathways by cyclophilin-cyclosporin complexes in T cell appears to shut down lymphokine-gene transcription.
Bentin
J
J
Clinic of Rheumatology, Hôpital Universitaire Erasme, Brussels, Belgium.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000503:physiopathology; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000187:drug effects; D003238:Connective Tissue / Q000187:drug effects; D016572:Cyclosporine / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000187:drug effects
D007166:Immunosuppressive Agents; D016572:Cyclosporine