title: Bradykinin B2 receptor antagonists: development and applications.
abstract: Most physiological and pathophysiological responses to bradykinin are mediated by G-protein-coupled receptors designated B2 receptors. Discovery of antagonists for these receptors has brought about a revolution in research in the kinin field. The chemistry and development of antagonists for B2 kinin receptors are discussed. Uses of the antagonists in biomedical research and potential clinical applications are presented.
authors.affiliation: Department of Biochemistry, University of Colorado Medical School, Denver 80262, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Stewart
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D065168:Bradykinin Receptor Antagonists; D006801:Humans; D008969:Molecular Sequence Data
chemical_list: D065168:Bradykinin Receptor Antagonists