Nucleocytoplasmic transport of proteins and control of cellular function.
Nucleocytoplasmic transport of proteins occurs through pores embedded in the nuclear envelope. Recent studies have defined the cytoplasmic factors required for signal-mediated import of nuclear proteins. Considerable progress has been made in understanding the mechanism of nuclear export of proteins by the identification of specific signal sequences needed for export. Regulatory molecules have been shown to adopt novel mechanisms to control their entry into the nucleus and thereby regulate their functions.
Parnaik
V K
VK
Centre for Cellular and Molecular Biology, Hyderabad, India.
D000595:Amino Acid Sequence; D000818:Animals; D002453:Cell Cycle; D002467:Cell Nucleus / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D015694:Gene Products, rev / Q000378:metabolism; D015497:HIV-1 / Q000378:metabolism; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism; D009685:Nuclear Envelope / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D021382:Protein Sorting Signals; D011506:Proteins / Q000378:metabolism*; D054321:rev Gene Products, Human Immunodeficiency Virus
D015694:Gene Products, rev; D016328:NF-kappa B; D021382:Protein Sorting Signals; D011506:Proteins; D054321:rev Gene Products, Human Immunodeficiency Virus