Thermogenic responses to high-energy phosphate contents and/or hindlimb suspension in rats.
Effects of chronic depletion of high-energy phosphate compounds by feeding beta-guanidinopropionic acid (beta-GPA) with or without hindlimb suspension (HS) on body temperature were studied in rats. Lower rectal and skin temperatures were observed in rats after 10 d of HS. Suspension-related enlargement of the interscapular brown adipose tissue (BAT), associated with adrenal hypertrophy, was seen. Feeding beta-GPA also caused a hypothermia and BAT enlargement. It is suggested that the hypothermic response to HS may be due to decreased contractile activity and metabolic rate in skeletal muscles, associated with stress. It is also speculated that the changes in the thermogenesis in rats fed beta-GPA might be related to a stimulated ATP synthesis with sacrificed heat production, but not associated with stress.
Wakatsuki
T
T
Department of Physiology and Biomechanics, National Institute of Fitness and Sports, Kanoya, Japan.
Hirata
F
F
Ohno
H
H
Yamamoto
M
M
Sato
Y
Y
Ohira
Y
Y
D000818:Animals; D001831:Body Temperature / Q000502:physiology*; D001833:Body Temperature Regulation / Q000502:physiology*; D001835:Body Weight / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D006146:Guanidines / Q000494:pharmacology; D006614:Hindlimb / Q000502:physiology*; D008297:Male; D010710:Phosphates / Q000378:metabolism*; D011422:Propionates / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D006146:Guanidines; D010710:Phosphates; D011422:Propionates; C005775:guanidinopropionic acid