title: [Agents inducing cell death of the vascular wall].
abstract: Arterial wall is constituted by endothelial cells, smooth muscle cells and fibroblasts. A number of agents are capable of inducing damages in these cells leading either to apoptosis or necrosis involved in various pathologies. Such agents are constituted by: bacterial endotoxins, mediators and modulators of immunitary and/or inflammatory systems, drugs, reactive oxygen metabolites, free radicals, cholesterol oxidation derivatives included or not in lipoproteins. The study of the mechanisms of action implied in cell death would permit a better understanding of vascular diseases and open new therapeutic perspectives.
authors.affiliation: Laboratoire de biochimie des lipoprotéines, hôpital du Bocage, Dijon, France.
authors.forename: B
authors.initials: B
authors.lastname: Munsch
authors.forename: G
authors.initials: G
authors.lastname: Lizard
authors.forename: S
authors.initials: S
authors.lastname: Gueldry
authors.forename: P
authors.initials: P
authors.lastname: Gambert
mesh_terms: D016923:Cell Death / Q000187:drug effects*; D004730:Endothelium, Vascular / Q000166:cytology*; D004731:Endotoxins / Q000494:pharmacology; D005347:Fibroblasts / Q000166:cytology*; D005609:Free Radicals / Q000494:pharmacology; D006801:Humans; D006888:Hydroxycholesterols / Q000494:pharmacology; D008077:Lipoproteins, LDL / Q000494:pharmacology; D009131:Muscle, Smooth, Vascular / Q000166:cytology*
chemical_list: D004731:Endotoxins; D005609:Free Radicals; D006888:Hydroxycholesterols; D008077:Lipoproteins, LDL