title: Association between a dimorphic site on chromosome 12 and clinical diagnosis of hypertension in three independent populations.
abstract: With the aim of identifying putative quantitative trait loci (QTLs) involved in the regulation of blood pressure, we have carried out association studies at a candidate genetic locus-a human pancreatic phospholipase A2 (PLA2) gene localized on chromosome 12. Positive associations were found between the presence of a Taq I dimorphic site localized in the first intron of this gene and hypertension in three sample populations (two from USA and one from Germany). These results indicate that a QTL implicated in determining an individual's genetic susceptibility to hypertension could be present within up to 30 cM of this human PLA2 gene.
authors.affiliation: Department of Pathology, Faculty of Medicine and Health Sciences, Al Ain, United Arab Emirates.
authors.forename: P M
authors.initials: PM
authors.lastname: Frossard
authors.forename: G G
authors.initials: GG
authors.lastname: Lestringant
mesh_terms: D002881:Chromosomes, Human, Pair 12; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D005787:Gene Frequency; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007962:Leukocytes / Q000502:physiology; D008875:Middle Aged; D010179:Pancreas / Q000737:chemistry; D010741:Phospholipases A / Q000235:genetics*; D054467:Phospholipases A2; D012150:Polymorphism, Restriction Fragment Length; D011159:Population Surveillance
chemical_list: D010741:Phospholipases A; D054467:Phospholipases A2; D015252:Deoxyribonucleases, Type II Site-Specific; C027046:TCGA-specific type II deoxyribonucleases