title: Massive hepatic necrosis and death following repeated isoflurane exposure: case report and review of the literature.
abstract: Multiple exposures to halothane have been shown to produce hepatic injury and subsequent hepatic failure often leading to death. Isoflurane, a related haloalkane, is considered a nonhepatotoxic alternative to halothane and its potential to cause injury has been greeted with skepticism. Described is a 30-year-old woman who developed hepatic failure and died after being exposed twice to isoflurane. Recent exposure to anesthetic agents must be considered when death is caused by massive hepatic necrosis.
authors.affiliation: Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston 29425, USA.
authors.forename: P L
authors.initials: PL
authors.lastname: Gelven
authors.forename: S J
authors.initials: SJ
authors.lastname: Cina
authors.forename: J D
authors.initials: JD
authors.lastname: Lee
authors.forename: C A
authors.initials: CA
authors.lastname: Nichols
mesh_terms: D000328:Adult; D018685:Anesthetics, Inhalation / Q000009:adverse effects; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007530:Isoflurane / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects* / Q000473:pathology*; D009336:Necrosis
chemical_list: D018685:Anesthetics, Inhalation; D007530:Isoflurane