title: Leukemoid reaction in epidermal squamous cell carcinoma.
abstract: There have been no previous concrete reports of leukemoid reactions associated with squamous cell carcinoma originating in cutaneous tissue. Here we report a case of epidermal squamous cell carcinoma of the sacral region and an associated leukemoid reaction. The tumor invaded deeply and destroyed both the sacrum and coccyx. The white blood cell count was greater than 20,000/mm3. After resection of the tumor, white blood cells transiently decreased, but did not fall under 10,000/mm3. Post-operative infection by methicillin-resistant Staphylococcus aureus and Bacteroides caccae caused sepsis and further elevation of the leukocytes to greater than 50,000/mm3. The leukemoid reaction in the case appeared to have been caused initially by direct invasion of bone by epidermal squamous cell carcinoma and later by severe infection.
authors.affiliation: Department of Dermatology, Jichi Medical School, Tochigi.
authors.forename: T
authors.initials: T
authors.lastname: Kiyosawa
authors.forename: S
authors.initials: S
authors.lastname: Hirano
authors.forename: J
authors.initials: J
authors.lastname: Nakamura
authors.forename: S
authors.initials: S
authors.lastname: Murata
authors.forename: T
authors.initials: T
authors.lastname: Demitsu
authors.forename: H
authors.initials: H
authors.lastname: Kato
authors.forename: H
authors.initials: H
authors.lastname: Yaoita
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000473:pathology / Q000601:surgery; D017809:Fatal Outcome; D006801:Humans; D007955:Leukemoid Reaction / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012445:Sacrococcygeal Region; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery