Measurement of the arterial concentration of Gd-DTPA using MRI: a step toward quantitative perfusion imaging.
A noninvasive method using an inversion recovery turbo-FLASH for dynamic measurement of the arterial input function represented by the bolus passage of Gd-DTPA in the descending aorta is presented, and the results are compared with the input function obtained by arterial blood samples. A good accordance between the two input functions was found, indicating that it is possible to measure the input function to the myocardium using MRI. A variation between the two concentration curves of 5% at upslope, 2.7% at peak point, and < 7% at downslope was found. The study also indicates that a short inversion time < 250 ms has to be used to ensure correct measurement of peak concentration.
Fritz-Hansen
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T
Danish Research Center of Magnetic Resonance, Hvidovre Hospital, Denmark.
Rostrup
E
E
Larsson
H B
HB
Søndergaard
L
L
Ring
P
P
Henriksen
O
O
D000328:Adult; D001013:Aorta, Thoracic; D001158:Arteries; D003287:Contrast Media / Q000032:analysis*; D005682:Gadolinium / Q000097:blood*; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds / Q000032:analysis*; D004369:Pentetic Acid / Q000031:analogs & derivatives* / Q000032:analysis; D019047:Phantoms, Imaging
D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA