Estimating linkage heterogeneity.
The admixture model for linkage heterogeneity is modified to take account of the difference in recombination fractions in the two sexes. The data used may concern a single (marker) locus on one chromosome, which is suspected of being sometimes near a (disease) locus for a particular condition of interest, or there may be data on more than one locus on this chromosome. There may be data on a locus or loci on a second chromosome, which is also suspected of sometimes carrying an allele for the condition in question. The general principle for the analysis is the same in all such cases, though details may differ. The object is to estimate the relevant recombination fractions, and the proportions of cases in which the allele for the condition falls on each chromosome.
Smith
C A
CA
Galton Laboratory, University College London.
Stephens
D A
DA
D002885:Chromosomes, Human, Pair 16; D002899:Chromosomes, Human, Pair 9; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D014402:Tuberous Sclerosis / Q000235:genetics