title: A gene for nonspecific X-linked mental retardation (MRX41) is located in the distal segment of Xq28.
abstract: We report on a family in which nonsyndromal mild to moderate mental retardation segregates as an X-linked trait (MRX41). Two point linkage analysis demonstrated linkage between the disorder and marker DXS3 in Xq21.33 with a lod score of 2.56 at theta = 0.0 and marker DXS1108 in Xq28 with a lod score of 3.82 at theta = 0.0. Multipoint linkage analysis showed that the odds for a location of the gene in Xq28 vs Xq21.33 are 100:1. This is the fourth family with non-specific X-linked mental retardation with Xq28-qter as the most likely gene localization.
authors.affiliation: Department of Human Genetics, University Hospital, Nijmegen, The Netherlands.
authors.forename: B C
authors.initials: BC
authors.lastname: Hamel
authors.forename: H
authors.initials: H
authors.lastname: Kremer
authors.forename: E
authors.initials: E
authors.lastname: Wesby-van Swaay
authors.forename: B
authors.initials: B
authors.lastname: van den Helm
authors.forename: A P
authors.initials: AP
authors.lastname: Smits
authors.forename: B A
authors.initials: BA
authors.lastname: Oostra
authors.forename: H H
authors.initials: HH
authors.lastname: Ropers
authors.forename: E C
authors.initials: EC
authors.lastname: Mariman
mesh_terms: D002874:Chromosome Mapping; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D008126:Lod Score; D008297:Male; D010375:Pedigree; D014960:X Chromosome