Augmentation by phthalimides of phorbol ester-induced expression of tumor necrosis factor alpha message.
N(alpha)-Phthalimidoglutarimide (thalidomide), 2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione (PP-33) and its 4,5,6,7-tetrafluoro derivative (FPP-33) augmented 12-O-tetradecanoylphorbol 13-acetate-induced production by human leukemia HL-60 cells of both tumor necrosis factor alpha (TNF-alpha) mRNA and secreted TNF-alpha protein. Intracellular TNF-alpha protein production was increased to a lesser extent.
Azuma
A
A
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Miyachi
H
H
Shibata
Y
Y
Hashimoto
Y
Y
Iwasaki
S
S
D015152:Blotting, Northern; D002273:Carcinogens / Q000633:toxicity*; D018922:HL-60 Cells; D006801:Humans; D054833:Isoindoles; D010797:Phthalimides / Q000633:toxicity*; D012333:RNA, Messenger / Q000096:biosynthesis; D015398:Signal Transduction / Q000187:drug effects; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity*; D013792:Thalidomide / Q000633:toxicity; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis* / Q000378:metabolism
C103309:2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione; C103310:2-(2,6-diisopropylphenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3-dione; D002273:Carcinogens; D054833:Isoindoles; D010797:Phthalimides; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D013792:Thalidomide; D013755:Tetradecanoylphorbol Acetate