Iron absorption in patients with chronic uremia on maintenance hemodialysis and in healthy volunteers measured with a simple oral iron load test.
Gastrointestinal iron absorption was measured by an oral iron load test in patients with uremia on maintenance hemodialysis (n = 19), with iron overload (n = 9), iron deficiency (n = 10) and in healthy volunteers (n = 9). After an overnight fast, serum iron was measured before, and 1, 2, 4 and 6 h after administration of 100 mg ferrous chloride. Bone marrow iron was assessed after staining with Prussian blue. The study shows that iron absorption is impaired in uremic patients. Even uremic subjects with iron deficiency absorbed significantly less than normal subjects. Patients with iron overload and uremia absorbed even less, showing that the iron status of the patient influences absorption also in uremia.
Goch
J
J
Department of Internal Medicine, University Hospital, Uppsala, Sweden.
Birgegård
G
G
Danielson
B G
BG
Wikström
B
B
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000378:metabolism; D002908:Chronic Disease; D005260:Female; D005293:Ferritins / Q000378:metabolism; D005296:Ferrous Compounds / Q000493:pharmacokinetics; D006801:Humans; D007408:Intestinal Absorption; D007501:Iron / Q000493:pharmacokinetics*; D000090463:Iron Deficiencies; D019190:Iron Overload / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014511:Uremia / Q000378:metabolism* / Q000628:therapy
D005296:Ferrous Compounds; D005293:Ferritins; D007501:Iron; C029451:ferrous chloride