title: Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human.
abstract: The Group IIA phospholipase gene (PLA2G2A) protein coding regions exhibit significant homology with recently described Group IIC (PLA2G2C) and Group V (PLA2GV) genes. All three genes are present in many mammalian species and are expressed in a tissue-specific pattern. Here, we demonstrate in human that they are tightly linked and map to chromosome 1p34-p36.1. We also show that the homologous mouse loci are tightly linked (no observed recombination) on the distal part of chromosome 4, a region exhibiting synteny with human 1p34-p36. Unlike its rodent counterpart, human PLA2G2C appears to be a nonfunctional pseudogene.
authors.affiliation: Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202-5251, USA. JTISCHF@INDYVAX.IUPUI.EDU
authors.forename: J A
authors.initials: JA
authors.lastname: Tischfield
authors.forename: Y R
authors.initials: YR
authors.lastname: Xia
authors.forename: D M
authors.initials: DM
authors.lastname: Shih
authors.forename: I
authors.initials: I
authors.lastname: Klisak
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: S J
authors.initials: SJ
authors.lastname: Engle
authors.forename: A N
authors.initials: AN
authors.lastname: Siakotos
authors.forename: M V
authors.initials: MV
authors.lastname: Winstead
authors.forename: J J
authors.initials: JJ
authors.lastname: Seilhamer
authors.forename: V
authors.initials: V
authors.lastname: Allamand
authors.forename: G
authors.initials: G
authors.lastname: Gyapay
authors.forename: A J
authors.initials: AJ
authors.lastname: Lusis
mesh_terms: D000818:Animals; D001483:Base Sequence; D002118:Calcium; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D003001:Cloning, Molecular; D003433:Crosses, Genetic; D004252:DNA Mutational Analysis; D005091:Exons / Q000235:genetics; D005796:Genes / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D017403:In Situ Hybridization; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009472:Neuronal Ceroid-Lipofuscinoses / Q000235:genetics; D010741:Phospholipases A / Q000235:genetics*; D054467:Phospholipases A2; D012150:Polymorphism, Restriction Fragment Length; D011544:Pseudogenes
chemical_list: D010741:Phospholipases A; D054467:Phospholipases A2; D002118:Calcium