Anti-inflammatory effect of flurbiprofen tape applied percutaneously to rats with adjuvant-induced arthritis.
The anti-inflammatory effect of flurbiprofen tape (FP-T) by topical application was investigated, and the findings were compared with the results of oral administration of flurbiprofen to adjuvant arthritic rats. The topical application of FP-T significantly suppressed both applied and non-applied hind paw edema, with a potency similar to that seen with the oral administration of flurbiprofen. Body weight also increased with these treatments. Plasma levels of flurbiprofen differed little between topical application of FP-T and oral administration of flurbiprofen. Gastric damage induced by topical application of FP-T was significantly less than that seen in case of oral administration of flurbiprofen. These results suggest that the anti-inflammatory effects of FP-T cannot be entirely explained by flurbiprofen permeating inflamed tissue below the application site; rather, flurbiprofen penetrating into the systemic circulation may explain these actions.
Uchida
S
S
Research Laboratory, Yutoku Pharmaceutical Industries Co., Ltd., Saga, Japan.
Morishita
T
T
Ikeda
Y
Y
Akashi
T
T
D000287:Administration, Topical; D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy*; D001835:Body Weight / Q000187:drug effects; D005480:Flurbiprofen / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D013997:Time Factors
D005480:Flurbiprofen