title: A randomized, double-blind, placebo-controlled study of bromocriptine in nonfluent aphasia.
abstract: We carried out a double-blind and placebo-controlled study of the efficacy of bromocriptine in the treatment of nonfluent aphasia. Seven patients received bromocriptine (up to 60 mg/d) and an identical placebo in a randomized order. End points were the number of content words, content units, and pauses > 3 seconds during the description of a figure; verbal naming; and verbal fluency. There were no significant benefits of bromocriptine over placebo in any of the variables examined.
authors.affiliation: Department of Behavioral Neurology, Raúl Carrea Institute of Neurological Research, Buenos Aires, Argentina.
authors.forename: L
authors.initials: L
authors.lastname: Sabe
authors.forename: F
authors.initials: F
authors.lastname: Salvarezza
authors.forename: A
authors.initials: A
authors.lastname: García Cuerva
authors.forename: R
authors.initials: R
authors.lastname: Leiguarda
authors.forename: S
authors.initials: S
authors.lastname: Starkstein
mesh_terms: D000328:Adult; D000368:Aged; D001039:Aphasia, Broca / Q000188:drug therapy* / Q000523:psychology; D001971:Bromocriptine / Q000009:adverse effects / Q000627:therapeutic use*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010919:Placebos; D013060:Speech; D016896:Treatment Outcome
chemical_list: D010919:Placebos; D001971:Bromocriptine