Expression of cyclin D1 and p53 protein in various malignant skin tumors.
BACKGROUND
Overexpression of cyclin D1 and p53 protein has been reported in many types of malignant tumors.


OBJECTIVE
We investigated whether cyclin D1 was detected immunohistochemically in various types of malignant tumors of the skin, comparable with p53 protein.


METHODS
Immunohistochemical staining of cyclin D1 and p53 protein was applied to squamous cell carcinoma, malignant melanoma and malignant fibrous histiocytoma and various kinds of benign skin tumors.


RESULTS
Cyclin D1 was positive only in malignant tumors at the same incidence as p53 protein.


CONCLUSIONS
Cyclin D1 immunohistochemical staining may be a malignant marker for various skin tumors.
Inohara
S
S
Department of Dermatology, Hyogo College of Medicine, Japan.
Kitagawa
K
K
Kitano
Y
Y
D015415:Biomarkers / Q000032:analysis; D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D019938:Cyclin D1; D016213:Cyclins / Q000032:analysis*; D018219:Histiocytoma, Benign Fibrous / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008545:Melanoma / Q000378:metabolism* / Q000473:pathology; D015513:Oncogene Proteins / Q000032:analysis*; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
D015415:Biomarkers; D016213:Cyclins; D015513:Oncogene Proteins; D016159:Tumor Suppressor Protein p53; D019938:Cyclin D1