The radical scavenging abilities of a new anti-nephritic drug, OPC-15161.
A new anti-nephritic drug, 6-(1H-indol-3-ylmethyl)-5-methoxy-3-(2-methylpropyl)-2-(1H)-pyr azi none 4-oxide (OPC-15161), a natural product derivative, did not react with the free radical, 1,1-diphenyl-2-picrylhydrazyl (DPPH) and was only slightly reactive with superoxide (O2-), but it easily reacted with hydroxyl radical (.OH). The scavenging ability of OPC-15161 against .OH was dependent on its concentration, and formed a new radical species by reaction with .OH. The structure of this new radical species is proposed.
Ozawa
T
T
Department of Bioregulation Research, National Institute of Radiological Sciences, Chiba, Japan.
Nakano
Y
Y
D015764:Bepridil / Q000031:analogs & derivatives / Q000737:chemistry; D001713:Biphenyl Compounds; D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers / Q000737:chemistry*; D017665:Hydroxyl Radical / Q000737:chemistry; D010851:Picrates; D011719:Pyrazines / Q000737:chemistry*; D013481:Superoxides / Q000737:chemistry
D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D011719:Pyrazines; D013481:Superoxides; C067708:OPC 15161; D017665:Hydroxyl Radical; D015764:Bepridil; C004931:1,1-diphenyl-2-picrylhydrazyl