title: Molecular studies on kinin receptors.
abstract: We describe the results of functional studies on DNA clones encoding functional bradykinin receptors derived from human, rat, and mouse sources and including both genomic and complementary DNA clones. In both the Xenopus oocyte and the COS cell expression systems, the receptors from human and rat showed the pharmacological properties of B2 receptors, but receptors from mouse displayed both B1- and B2-like pharmacological properties. We further investigated the molecular relationship between the B1 and B2 receptor subtypes expressed by a human fibroblast cell line, and we demonstrate that these two receptor subtypes are encoded by distinct mRNA species.
authors.affiliation: Sandoz Institute for Medical Research, London, United Kingdom.
authors.forename: M
authors.initials: M
authors.lastname: Brown
authors.forename: M
authors.initials: M
authors.lastname: Webb
authors.forename: E
authors.initials: E
authors.lastname: Phillips
authors.forename: E
authors.initials: E
authors.lastname: Skidmore
authors.forename: P
authors.initials: P
authors.lastname: McIntyre
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D003001:Cloning, Molecular; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009865:Oocytes / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D018002:Receptors, Bradykinin / Q000235:genetics*; D014162:Transfection; D014981:Xenopus
chemical_list: D012333:RNA, Messenger; D018002:Receptors, Bradykinin