title: Induction of anaesthesia by propofol and hepatic blood flow in the rabbit.
abstract: Effects of propofol (12.5 mg kg-1, i.v. bolus injection) or 0.9% sodium chloride on arterial blood pressure, arterial blood gases and hepatic circulation (radio-labelled microsphere technique) were studied in 15 conscious and unpremedicated rabbits. No significant changes were observed after sodium chloride. Propofol resulted in anaesthesia, respiratory depression (-49 +/- 14% decrease in PaO2; mean +/- SD) and hypotension (-49 +/- 13% decrease in mean arterial pressure; mean +/- SD) but no changes in hepatic arterial and portal venous blood flows. We conclude that propofol does not affect the liver circulation despite marked depression of mean arterial pressure and respiration.
authors.affiliation: Département d'Anesthésie-Réanimation Chirurgicale, Hôtel-Dieu, Nantes, France.
authors.forename: D
authors.initials: D
authors.lastname: Demeure dit Latte
authors.forename: J M
authors.initials: JM
authors.lastname: Bernard
authors.forename: Y
authors.initials: Y
authors.lastname: Blanloeil
authors.forename: P
authors.initials: P
authors.lastname: Peltier
authors.forename: T
authors.initials: T
authors.lastname: Francois
authors.forename: J F
authors.initials: JF
authors.lastname: Chatal
mesh_terms: D000758:Anesthesia; D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects*; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects; D008099:Liver / Q000187:drug effects*; D015742:Propofol / Q000494:pharmacology*; D011817:Rabbits; D011869:Radioligand Assay; D013997:Time Factors
chemical_list: D015742:Propofol