Metabolic alkalosis and myoclonus from antacid ingestion.
A patient with a history of cerebrovascular disease, hypertension, and previous gastrectomy developed metabolic alkalosis and myoclonus. His medications included the anti-hypertensive agents nicardipine hydrochloride, delapril, prazosin; dihydroergotoxin and ticlopidine for cerebral infarction; estazolam for insomnia; azuren-L-glutamine compound and S-M powder. In addition, he had taken 12 grams per day of Ohta's Isan antacid, which contained 625 mg sodium bicarbonate per 1.3 g of antacid powder over a 6-month period. This antacid is commonly used in Japan. This is the first report of a case of metabolic alkalosis and myoclonus secondary to ingestion of a commercially available antacid in Japan.
Okada
K
K
Internal Medicine III, Shimane Medical University, Izumo.
Kono
N
N
Kobayashi
S
S
Yamaguchi
S
S
D000368:Aged; D000471:Alkalosis / Q000139:chemically induced*; D000863:Antacids / Q000009:adverse effects*; D002317:Cardiovascular Agents / Q000627:therapeutic use; D002544:Cerebral Infarction / Q000150:complications / Q000188:drug therapy; D004415:Dyspepsia / Q000150:complications / Q000188:drug therapy; D005743:Gastrectomy; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D007008:Hypokalemia / Q000139:chemically induced; D008297:Male; D009207:Myoclonus / Q000139:chemically induced*; D007319:Sleep Initiation and Maintenance Disorders / Q000150:complications / Q000188:drug therapy; D017693:Sodium Bicarbonate / Q000009:adverse effects*
D000863:Antacids; D002317:Cardiovascular Agents; D006993:Hypnotics and Sedatives; D017693:Sodium Bicarbonate