title: Calcitonin gene-related peptide: vasoactive effects and potential therapeutic role.
abstract: 1. The cardiovascular biology of calcitonin gene-related peptide (CGRP) and the structurally related peptides amylin and adrenomedullin are briefly reviewed. 2. CGRP is a potent and long-lasting vasodilator; its possible role in disease, and the therapeutic potential of CGRP receptor agonists and antagonists is discussed.
authors.affiliation: Pharmacology Group, King's College, London, England.
authors.forename: S D
authors.initials: SD
authors.lastname: Brain
authors.forename: H
authors.initials: H
authors.lastname: Cambridge
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology* / Q000627:therapeutic use*; D000077221:Calcitonin Gene-Related Peptide Receptor Antagonists; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008969:Molecular Sequence Data; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000819:agonists; D014665:Vasodilator Agents / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000077221:Calcitonin Gene-Related Peptide Receptor Antagonists; D018015:Receptors, Calcitonin Gene-Related Peptide; D014665:Vasodilator Agents; D015740:Calcitonin Gene-Related Peptide