[Cytokines during the perisurgical period].
Systematic inflammatory response syndrome, SIRS, is one of the biological responses to surgical and anesthetic invasions. SIRS itself is a defense response, but excessive SIRS may result in post-operative failure of major organs. There is evidence that inflammatory cytokines play an important role in SIRS. Therefore it may be treated by regulating these inflammatory cytokines. Changes in inflammatory cytokines during the perisurgical period were discussed in relation to post-operative organ injury in patients who had undergone highly invasive procedures such as open heart surgery or resection of esophageal cancer to explore the possibility of anticytokine therapy.
Kawamura
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Department of Anesthesiology, School of Medicine, Iwate Medical University, Morioka, Japan.
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D006348:Cardiac Surgical Procedures; D016207:Cytokines / Q000502:physiology*; D004938:Esophageal Neoplasms / Q000601:surgery; D006023:Glycoproteins / Q000627:therapeutic use; D006801:Humans; D007431:Intraoperative Complications / Q000188:drug therapy / Q000209:etiology*; D008775:Methylprednisolone / Q000627:therapeutic use; D009102:Multiple Organ Failure / Q000188:drug therapy / Q000209:etiology; D011183:Postoperative Complications / Q000188:drug therapy / Q000209:etiology; D018746:Systemic Inflammatory Response Syndrome / Q000188:drug therapy / Q000209:etiology
D000893:Anti-Inflammatory Agents; D016207:Cytokines; D006023:Glycoproteins; C028665:urinastatin; D008775:Methylprednisolone