title: Central mechanisms of tremor.
abstract: Physiologic and pathologic tremors are mechanistically classified into two broad groups: (1) those produced by oscillation in sensorimotor loops, so-called mechanical-reflex tremors, and (2) those produced by the oscillatory properties of central neuronal networks. This review provides a contemporary perspective of tremor pathophysiology while acknowledging that no form of tremor is understood completely. Indeed, the origin of oscillation in most forms of tremor is undefined, and in many instances the underlying pathology is unknown.
authors.affiliation: Department of Neurology, Southern Illinois University School of Medicine, Springfield 62794-9230, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Elble
mesh_terms: D001479:Basal Ganglia / Q000503:physiopathology*; D002531:Cerebellum / Q000503:physiopathology; D004298:Dopamine / Q000502:physiology; D005971:Glutamates / Q000502:physiology; D006801:Humans; D008636:Mesencephalon / Q000503:physiopathology; D009069:Movement Disorders / Q000175:diagnosis / Q000503:physiopathology; D014202:Tremor / Q000175:diagnosis / Q000503:physiopathology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
chemical_list: D005971:Glutamates; D005680:gamma-Aminobutyric Acid; D004298:Dopamine