Cytosolic and mitochondrial enzymes inactivation by uroporphyrin in light and darkness.
The effect of uroporphyrin I (UI) on several cytosolic and mitochondrial enzymes (succinyl CoA synthetase, delta-aminolevulinic acid synthetase, rhodanese, lactate dehydrogenase) has been examined. All the enzymes were inactivated in the presence of the porphyrin both in the dark and under UV light.
Afonso
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SG
Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), University of Buenos Aires, Argentine.
Enriquez de Salamanca
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Batlle
A M
AM
D000624:5-Aminolevulinate Synthetase / Q000037:antagonists & inhibitors; D000818:Animals; D002417:Cattle; D003593:Cytoplasm / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005969:Glutamate Dehydrogenase / Q000037:antagonists & inhibitors; D007770:L-Lactate Dehydrogenase / Q000037:antagonists & inhibitors*; D008930:Mitochondria, Liver / Q000201:enzymology; D008931:Mitochondria, Muscle / Q000201:enzymology; D017319:Photosensitizing Agents / Q000494:pharmacology; D011817:Rabbits; D013389:Succinate-CoA Ligases / Q000037:antagonists & inhibitors; D013884:Thiosulfate Sulfurtransferase / Q000037:antagonists & inhibitors*; D014466:Ultraviolet Rays / Q000009:adverse effects; D014578:Uroporphyrins / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D017319:Photosensitizing Agents; D014578:Uroporphyrins; C034103:uroporphyrin I; D007770:L-Lactate Dehydrogenase; D005969:Glutamate Dehydrogenase; D000624:5-Aminolevulinate Synthetase; D013884:Thiosulfate Sulfurtransferase; D013389:Succinate-CoA Ligases