A neuroimmune hypothesis for the aetiopathology of viral illness and manic depression: a case report of an adolescent.
This paper explores the unifying aetiopathology between disorders of the immune system and the CNS, using a case example. An adolescent had a 2-year history of chronic-active Epstein-Barr virus infection and recurrent acute pancreatitis that resolved following a course of immunotherapy. Subsequently, she redeveloped acute symptoms of infectious mononucleosis and pancreatitis, along with manic depression, and then made a complete recovery with combination of lithium carbonate and electroconvulsive therapy. On follow-up, lithium carbonate effectively controlled the previous neuroimmune dysfunction.
Pavuluri
M N
MN
Department of Child and Adolescent Psychiatry, Royal Children's Hospital, Parkville, Australia.
Smith
M
M
D000208:Acute Disease; D000293:Adolescent; D000956:Antigens, Viral / Q000097:blood; D018692:Antimanic Agents / Q000008:administration & dosage; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology* / Q000523:psychology / Q000628:therapy; D001714:Bipolar Disorder / Q000175:diagnosis / Q000276:immunology* / Q000523:psychology / Q000628:therapy; D001921:Brain / Q000276:immunology; D003131:Combined Modality Therapy; D004565:Electroconvulsive Therapy; D006801:Humans; D007244:Infectious Mononucleosis / Q000175:diagnosis / Q000276:immunology* / Q000523:psychology / Q000628:therapy; D016651:Lithium Carbonate / Q000008:administration & dosage; D019965:Neurocognitive Disorders / Q000175:diagnosis / Q000276:immunology* / Q000523:psychology / Q000628:therapy; D009474:Neurons / Q000276:immunology; D010195:Pancreatitis / Q000175:diagnosis / Q000276:immunology / Q000523:psychology / Q000628:therapy; D017981:Receptors, Neurotransmitter / Q000276:immunology
D000956:Antigens, Viral; D018692:Antimanic Agents; D017981:Receptors, Neurotransmitter; D016651:Lithium Carbonate