title: HmGlu1d, a novel splice variant of the human type I metabotropic glutamate receptor.
abstract: A novel splice variant, hmGlu1d, of the human mGlu1 metabotropic glutamate receptor has been isolated from a human brain library. This clone is identical to human mGlu1a except that it lacks 35 nucleotides in the 3' coding sequence, which predicts a truncated protein and a novel carboxy terminus. After injection of the encoding sequence into mouse A9 fibroblasts, quisqualate and (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3R)-ACPD) elicited concentration-dependent increases in intracellular Ca2+ (pEC50 values of 6.09 and 4.33, respectively).
authors.affiliation: Preclinical Research, Sandoz Pharma AG, Basle, Switzerland.
authors.forename: D J
authors.initials: DJ
authors.lastname: Laurie
authors.forename: H W
authors.initials: HW
authors.lastname: Boddeke
authors.forename: R
authors.initials: R
authors.lastname: Hiltscher
authors.forename: B
authors.initials: B
authors.lastname: Sommer
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D017931:DNA Primers; D018076:DNA, Complementary; D006801:Humans; D008969:Molecular Sequence Data; D012326:RNA Splicing; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
chemical_list: D017931:DNA Primers; D018076:DNA, Complementary; D018094:Receptors, Metabotropic Glutamate