The role of Sec1p-related proteins in vesicle trafficking in the nerve terminal.
Vesicle trafficking at multiple stages of the secretory pathway depends on a family of soluble proteins related to yeast Sec1p. In yeast, this family consists of four members: the late-acting Sec1p that is required for vesicular transport between the Golgi apparatus and the cell surface; Vps33p and Vps45p which are required for trafficking between the Golgi complex and the lysosome-like vacuole; and Sly1p that is essential for trafficking between the endoplasmic reticulum and the Golgi apparatus. In mammalian systems, homologues of these proteins have been identified. In particular, a neural-specific Sec1p homologue (n-sec1/Munc-18) binds the plasma membrane protein syntaxin and may regulate synaptic vesicle docking. The Sec1p family of proteins is essential for vesicle trafficking in both regulated and constitutive trafficking pathways, and n-sec1 is critical in the regulated release of neurotransmitter from the nerve terminal.
Pevsner
J
J
Kennedy Krieger Research Institute, Baltimore, Maryland, USA.
D000818:Animals; D017173:Caenorhabditis elegans; D004330:Drosophila; D004721:Endoplasmic Reticulum / Q000502:physiology; D005656:Fungal Proteins / Q000502:physiology; D006056:Golgi Apparatus / Q000502:physiology; D006801:Humans; D008322:Mammals; D008565:Membrane Proteins / Q000502:physiology; D008954:Models, Biological; D008959:Models, Neurological; D051938:Munc18 Proteins; D009411:Nerve Endings / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology*; D050765:Qa-SNARE Proteins; D012441:Saccharomyces cerevisiae / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins; D013572:Synaptic Vesicles / Q000502:physiology*; D033921:Vesicular Transport Proteins
D005656:Fungal Proteins; D008565:Membrane Proteins; D051938:Munc18 Proteins; D009419:Nerve Tissue Proteins; D050765:Qa-SNARE Proteins; C497931:SEC1 protein, S cerevisiae; C497937:STXBP1 protein, human; D029701:Saccharomyces cerevisiae Proteins; D033921:Vesicular Transport Proteins