title: [Studies on the synthesis of cholecystokinin A receptor antagonists. IV. Synthesis and cholecystokinin A receptor inhibitory activities of benzimidazole derivatives].
abstract: A number of benzimidazole derivatives were synthesized and tested for cholecystokinin A (CCK-A) receptor inhibitory activity in order to study structure-activity relationships. Significant CCK-A receptor inhibitory activities were found in the compounds having carboxyl or tetrazolyl group. As the most preferred compound, 4-(5,6-dichlorobenzimidazol-2-yl)-N-(3-methoxypropyl)-N-pentylg lutaramic acid (4g) was selected.
authors.affiliation: Central Research Laboratories, Kissei Pharmaceutical Co. Ltd., Nagano, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ajisawa
authors.forename: K
authors.initials: K
authors.lastname: Akahane
authors.forename: M
authors.initials: M
authors.lastname: Akahane
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Tamai
authors.forename: M
authors.initials: M
authors.lastname: Saito
authors.forename: N
authors.initials: N
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Kamata
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000478:Alkylation; D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D006868:Hydrolysis; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D043886:Receptor, Cholecystokinin A; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D001562:Benzimidazoles; D043886:Receptor, Cholecystokinin A; D011949:Receptors, Cholecystokinin; C031000:benzimidazole