Pemoline-induced autoimmune hepatitis.
We present a case of pemoline-induced autoimmune hepatitis in a 46-yr-old woman who received the drug for management of her multiple sclerosis. The autoimmune nature of the hepatitis is based on elevation of her anti-nuclear antibodies, anti-thyroid antibodies, IgA, and IgM globulins. These features of autoimmunity disappeared with normalization of her liver-associated enzymes and have remained negative for at least 6 months after completion of prednisone therapy.
Sterling
M J
MJ
Division of Gastroenterology, Faulkner Hospital, School of Medicine, Boston, Massachusetts, USA.
Kane
M
M
Grace
N D
ND
D000974:Antibodies, Antinuclear / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000139:chemically induced* / Q000188:drug therapy; D000697:Central Nervous System Stimulants / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy; D010389:Pemoline / Q000009:adverse effects* / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D013961:Thyroid Gland / Q000276:immunology
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D000697:Central Nervous System Stimulants; D005938:Glucocorticoids; D007070:Immunoglobulin A; D007075:Immunoglobulin M; D010389:Pemoline; D011241:Prednisone