title: Effect of vaccination with an Escherichia coli bacterin-toxoid on milk production in dairy cattle.
abstract: OBJECTIVE
  To determine whether vaccination of lactating cattle with an Escherichia coli J5 bacterin-toxoid would produce a significant short-term change in milk production.
  
  
  METHODS
  Randomized, controlled clinical trial.
  
  
  METHODS
  84 healthy, lactating cows (42 Holsteins and 42 Jerseys).
  
  
  METHODS
  Control and vaccinated cows were paired on the basis of breed, days in milk, daily milk production 1 week prior to vaccination, and parity. One cow in each pair was inoculated IM with a commercially available bacterin-toxoid according to label directions; the other cow was given saline solution. Cows were milked twice daily for 5 days before and 5 days after inoculation. Milk production was compared by ANCOVA.
  
  
  RESULTS
  Vaccinated cows produced significantly less milk than did control cows at the second and third milkings after inoculation. At these milkings, milk production in vaccinated cows was approximately 7% less than that of controls.
  
  
  CONCLUSIONS
  Vaccination of lactating cattle with an E coli J5 bacterin-toxoid may cause a significant short-term decrease in milk production.
authors.affiliation: Department of Food Animal and Equine Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Musser
authors.forename: K L
authors.initials: KL
authors.lastname: Anderson
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000009:adverse effects*; D002417:Cattle / Q000502:physiology*; D004926:Escherichia coli / Q000276:immunology*; D004927:Escherichia coli Infections / Q000517:prevention & control / Q000662:veterinary*; D022361:Escherichia coli Vaccines; D005260:Female; D007774:Lactation / Q000187:drug effects*; D008414:Mastitis, Bovine / Q000517:prevention & control*; D014121:Toxoids / Q000009:adverse effects / Q000276:immunology; D014611:Vaccination / Q000009:adverse effects / Q000662:veterinary
chemical_list: D001428:Bacterial Vaccines; D022361:Escherichia coli Vaccines; D014121:Toxoids