[Intra-arterial infusion chemotherapy for breast cancer].
In order to reduce toxic effects while attaining maximal therapeutic effects, epirubicin 10 mg/day, cyclophosphamide 100 mg/day and prednisolone 10 mg/day were administered through in indwelling catheter inserted into the internal mammary artery and/or subclavian artery for 3-4 weeks, employing the implantable port system for the treatment of unresectable breast cancer and recurrent cancer. Ten out of 11 patients (91%) with unresectable breast cancer showed a response (CR 3, PR 7, NC 1) to this modality of intra-arterial infusion chemotherapy. Seven out of 11 patients (64%) with recurrent cancer of the breast showed a response (CR 1, PR 6, NC 4). Intraarterial infusion chemotherapy for the unresectable advanced breast cancer and recurrent breast cancer proved to be an effective modality of treatment.
Matsumoto
Y
Y
Miura Hospital, Japan.
Terakado
H
H
Ikawa
M
M
Hamada
E
E
Watanabe
Y
Y
Nakasato
S
S
Takaki
S
S
Murata
M
M
Miura
T
T
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D011239:Prednisolone / Q000008:administration & dosage
D015251:Epirubicin; D003520:Cyclophosphamide; D011239:Prednisolone; D005472:Fluorouracil