title: Intraperitoneal administration of Senegae Radix extract and its main component, senegin-II, affects lipid metabolism in normal and hyperlipidemic mice.
abstract: The hypolipidemic effect of Senegae Radix, i.e. "Senega," was investigated in normal and hyperlipidemic mice. The n-butanol fraction of the methanol extract of Senegae Radix (SN) (5 mg/kg) significantly reduced the blood triglyceride level of normal mice 7 h after intraperitoneal administration (p < 0.05) and also significantly reduced the blood triglyceride level of cholesterol-fed mice under similar conditions (p < 0.05). SN (5 mg/kg) also reduced the blood triglyceride and cholesterol levels after repeated administration to cholesterol-fed mice. SN also decreased the blood triglyceride level in Triton-induced hyperlipidemia. It is suggested that this fraction contains one or more hypolipidemic components including the main triterpenoid glycoside, senegin-II, which significantly reduces the levels of blood triglycerides in normal mice.
authors.affiliation: Suzuka University Medical Sciense and Technology, Mie, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Masuda
authors.forename: K
authors.initials: K
authors.lastname: Ohsumi
authors.forename: M
authors.initials: M
authors.lastname: Kako
authors.forename: T
authors.initials: T
authors.lastname: Miura
authors.forename: Y
authors.initials: Y
authors.lastname: Nishiyama
authors.forename: M
authors.initials: M
authors.lastname: Ichimaru
authors.forename: M
authors.initials: M
authors.lastname: Moriyasu
authors.forename: A
authors.initials: A
authors.lastname: Kato
mesh_terms: D000818:Animals; D006949:Hyperlipidemias / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D050356:Lipid Metabolism; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000960:Hypolipidemic Agents; D010936:Plant Extracts