Itraconazole in the treatment of orbital aspergillosis.
BACKGROUND
Sino-orbital aspergillosis is typically treated with surgical debridement and intravenous amphotericin B. Some authors have advocated intraorbital irrigation or injection of amphotericin B in specific cases.


METHODS
An immunocompetent patient with recurrent sino-orbital aspergillosis is presented. After failing two attempts at traditional therapeutic modalities, treatment with oral itraconazole was initiated.


RESULTS
The patient has had resolution of her sino-orbital disease without recurrence at 10 months of follow-up.


CONCLUSIONS
In immunocompetent patients with orbital aspergillosis, itraconazole should be considered as a treatment option in patients who have recurrent or recalcitrant disease, or in those who cannot tolerate amphotericin B.
Massry
G G
GG
Department of Ophthalmology, St. Louis University School of Medicine, Anheuser-Busch Eye Institute, USA.
Hornblass
A
A
Harrison
W
W
D000284:Administration, Oral; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000473:pathology; D001232:Aspergillus fumigatus / Q000302:isolation & purification; D015821:Eye Infections, Fungal / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D017964:Itraconazole / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D009915:Orbit / Q000382:microbiology; D009916:Orbital Diseases / Q000188:drug therapy* / Q000382:microbiology* / Q000473:pathology; D012008:Recurrence
D000935:Antifungal Agents; D017964:Itraconazole