Mortality and morbidity in treated hypertensive type 2 diabetic patients with micro- or macroproteinuria.
In order to describe the natural history of high risk diabetic patients treated for hypertension we have followed a sequential sample of 100 hypertensive Type 2 diabetic patients with elevated urinary protein excretion ( > or = 60 mg 24 h-1) for a period of 1-7 years. Antihypertensive treatment was instituted in all patients and, in addition, the patients were offered the possibility of participation in an intensified antihypertensive therapy programme. After a mean follow-up of 4 years overall mortality was 13%. Nineteen percent of all patients experienced a cardiovascular event and 7% a cerebrovascular event. In conclusion, in this study the overall mortality was lower that previously reported in proteinuric Type 2 diabetic patients. Antihypertensive treatment may account for this outcome.
Sawicki
P T
PT
Medical Department for Metabolic Diseases and Nutrition, (WHO Collaborating Centre for Diabetes), Heinrich-Heine University of Düsseldorf, Germany.
Mühlhauser
I
I
Didjurgeit
U
U
Reimann
M
M
Bender
R
R
Berger
M
M
D000367:Age Factors; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000401:mortality; D002561:Cerebrovascular Disorders / Q000453:epidemiology / Q000401:mortality; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000453:epidemiology* / Q000401:mortality; D004232:Diuretics / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000453:epidemiology* / Q000401:mortality; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D016016:Proportional Hazards Models; D011507:Proteinuria / Q000453:epidemiology* / Q000401:mortality; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome
D000959:Antihypertensive Agents; D004232:Diuretics