title: Haemodynamic and metabolic responses of the lower limb after high intensity exercise in humans.
abstract: This study assessed blood flow in the common femoral, superficial femoral and profunda femoris arteries, the effects of vasodilator metabolites and changes in blood pressure and pulse during recovery after high intensity exercise (Wingate test). Mean common femoral artery flow increased sevenfold in response to the exercise. The subsequent decline in mean common femoral artery flow was mono-exponential with a mean time constant of 19 min. The post-exercise increase in profunda femoris artery flow (ninefold) was significantly greater than the superficial femoral artery flow (fourfold, P < 0.05). Systolic blood pressure and heart rate decreased monotonically throughout recovery. In contrast, diastolic blood pressure showed a significant fall below baseline at 3 min (P < 0.05) with a return to baseline at 60 min. The greatest drop below baseline (approximately 20 mmHg) occurred around 7 min. Lactate reached a maximum of 13.6 +/- 2.3 mmol -1 at 8 min (P < 0.05) and was still significantly above baseline at 60 min. pH remained below 7.2 until 20 min of recovery. The results demonstrate that following high intensity exercise, blood flow to the limbs appears to be controlled by complex interactions of various vaso-active metabolites, each contributing proportionally more at different times during recovery.
authors.affiliation: Professorial Surgical Unit, Medical College of St Bartholomew's Hospital, London, UK.
authors.forename: S T
authors.initials: ST
authors.lastname: Hussain
authors.forename: R E
authors.initials: RE
authors.lastname: Smith
authors.forename: S
authors.initials: S
authors.lastname: Medbak
authors.forename: R F
authors.initials: RF
authors.lastname: Wood
authors.forename: B J
authors.initials: BJ
authors.lastname: Whipp
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D001794:Blood Pressure; D002395:Catecholamines / Q000097:blood; D004573:Electrolytes / Q000097:blood; D016552:Ergometry; D015444:Exercise / Q000502:physiology*; D005263:Femoral Artery / Q000502:physiology; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D007700:Kinetics; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D007866:Leg / Q000502:physiology*; D008297:Male; D014664:Vasodilation
chemical_list: D002395:Catecholamines; D004573:Electrolytes; D007773:Lactates; D019344:Lactic Acid