Pharmacological characterization of glial cell line-derived neurotrophic factor (GDNF): implications for GDNF as a therapeutic molecule for treating neurodegenerative diseases.
This review presents a comprehensive survey of the recently described pharmacological activities of glial cell line-derived neurotrophic factor on the central nervous system.
Lapchak
P A
PA
AMGEN Inc., Department of Neuroscience, MC 5-1-C, 1840 de Havilland Drive, Thousand Oaks, CA 91320-1789, USA. plapchak@amgen.com
Jiao
S
S
Miller
P J
PJ
Williams
L R
LR
Cummins
V
V
Inouye
G
G
Matheson
C R
CR
Yan
Q
Q
D000818:Animals; D051100:Glial Cell Line-Derived Neurotrophic Factor; D006801:Humans; D009410:Nerve Degeneration / Q000187:drug effects*; D009414:Nerve Growth Factors / Q000494:pharmacology*; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D009422:Nervous System Diseases / Q000188:drug therapy*; D018696:Neuroprotective Agents / Q000494:pharmacology*
C495039:GDNF protein, human; D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D018696:Neuroprotective Agents