title: Immediate cardiac allograft failure. ECMO versus total artificial heart support.
abstract: Optimal support for immediate cardiac allograft failure is unknown. With the introduction of heparin bonded extracorporeal membrane oxygenated circuits, prolonged cardiopulmonary support is possible. The authors report a case that involved 2 days of right atrial to ascending aorta extracorporeal membrane oxygenated support after immediate donor organ failure prevented the patient from exiting bypass. Continued deterioration in cardiac function led to an attempt at conversion to a total artificial heart as a bridge to retransplant. However, this procedure resulted in transbronchial exsanguination and recipient death. The autopsy showed pulmonary thrombosis with infarction and hemorrhage. The authors recommend caution in the use of extracorporeal membrane oxygenated support for patients with immediate and profound graft failure because of the increased risk of stasis thrombosis and pulmonary infarction due to sluggish pulmonary and left atrial blood flow. Instead, institution of total artificial heart or biventricular support may be preferable as the risks of thrombus and infarction are less.
authors.affiliation: Sharp Memorial Hospital, San Diego, California, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Adamson
authors.forename: W P
authors.initials: WP
authors.lastname: Dembitsky
authors.forename: P O
authors.initials: PO
authors.lastname: Daily
authors.forename: R
authors.initials: R
authors.lastname: Moreno-Cabral
authors.forename: J
authors.initials: J
authors.lastname: Copeland
authors.forename: R
authors.initials: R
authors.lastname: Smith
mesh_terms: D000293:Adolescent; D003326:Coronary Circulation / Q000502:physiology; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects; D005260:Female; D006333:Heart Failure / Q000401:mortality / Q000628:therapy*; D006354:Heart, Artificial / Q000009:adverse effects; D006470:Hemorrhage / Q000401:mortality; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007238:Infarction / Q000401:mortality; D008297:Male; D008875:Middle Aged; D013927:Thrombosis / Q000401:mortality; D014019:Tissue Donors
chemical_list: D006493:Heparin