An EcoRI RFLP in human APC gene.
A novel EcoRI-restriction fragment length polymorphism in the genomic sequence of the human adenomatous polyposis coli (APC) gene is described. This polymorphism in the APC gene would be very useful for examination of segregation of the mutated APC gene in the kindreds of familial adenomatous polyposis, and also for studying the loss of heterozygosity at the APC region in certain tumors.
Kurahashi
H
H
Department of Medical Genetics, Osaka University Medical School, Japan.
Takami
K
K
Yana
I
I
Akagi
K
K
Okada
S
S
Nishisho
I
I
D015246:Deoxyribonuclease EcoRI; D017491:Genes, APC / Q000235:genetics*; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length
D015246:Deoxyribonuclease EcoRI