title: New bioactive marine steroids from the Okinawan soft coral Clavularia viridis.
abstract: Eight new marine steroids were isolated from the Okinawan soft coral Clavularia viridis Quoy and Gaimard. Their structures were determined based on spectroscopic analysis, chemical conversion, and X-ray crystallographic analysis. Steroids 5 and 6 showed growth inhibition activity toward HeLa S3 cells and human diploid cells in vitro.
authors.affiliation: Laboratory of Bioorganic Chemistry, School of Life Science, Tokyo University of Pharmacy, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: M
authors.initials: M
authors.lastname: Iwashima
authors.forename: K
authors.initials: K
authors.lastname: Iguchi
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003063:Cnidaria / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D007564:Japan; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D013256:Steroids; C103409:stoloniferone 5; C103410:stoloniferone 6