title: Effect of estriol on bone loss in postmenopausal Japanese women: a multicenter prospective open study.
abstract: OBJECTIVE
  To assess the effects of oral estriol on the bone mineral density (BMD) and bone metabolism in postmenopausal women.
  
  
  METHODS
  Seventy-five natural postmenopausal women with a BMD of more than 10% below the peak bone density were treated for 50 weeks with 2 mg/day estriol (E3) cyclically and 0.8 g/day of calcium lactate continuously. BMDs at L2-L4 were measured by dual energy X-ray absorptiometry (DXA).
  
  
  RESULTS
  The BMD increased 1.79% (p < 0.01 vs. pretreatment) after 50 weeks, accompanied with decrease of biochemical markers of bone turnover. With regard to climacteric symptoms, Kupperman's menopausal index improved (p < 0.01 vs. pretreatment) after 5 weeks of treatment. As to the incidence of adverse events genital bleeding was observed in only 8.0% of the subjects. Endometrial histology and cytology showed neither abnormalities nor hyperplasia during and after the treatment.
  
  
  CONCLUSIONS
  Estriol prevented postmenopausal bone loss and improved climacteric symptoms effectively with low incidence of genital bleeding.
authors.affiliation: Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Kanagawa, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Minaguchi
authors.forename: T
authors.initials: T
authors.lastname: Uemura
authors.forename: K
authors.initials: K
authors.lastname: Shirasu
authors.forename: A
authors.initials: A
authors.lastname: Sato
authors.forename: S
authors.initials: S
authors.lastname: Tsukikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ibuki
authors.forename: H
authors.initials: H
authors.lastname: Mizunuma
authors.forename: T
authors.initials: T
authors.lastname: Aso
authors.forename: T
authors.initials: T
authors.lastname: Koyama
authors.forename: S
authors.initials: S
authors.lastname: Nozawa
authors.forename: H
authors.initials: H
authors.lastname: Ohta
authors.forename: T
authors.initials: T
authors.lastname: Ikeda
authors.forename: K
authors.initials: K
authors.lastname: Kusuhara
authors.forename: K
authors.initials: K
authors.lastname: Ochiai
authors.forename: J
authors.initials: J
authors.lastname: Kato
authors.forename: T
authors.initials: T
authors.lastname: Kinoshita
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Minagawa
authors.forename: T
authors.initials: T
authors.lastname: Kurabayashi
authors.forename: M
authors.initials: M
authors.lastname: Fukunaga
mesh_terms: D015519:Bone Density / Q000187:drug effects; D002979:Climacteric / Q000187:drug effects; D004964:Estriol / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000097:blood / Q000517:prevention & control*; D011446:Prospective Studies
chemical_list: D004964:Estriol