title: Mifepristone prevents the expression of long-term behavioural sensitization to amphetamine.
abstract: Three weeks following intermittent amphetamine exposure (2.5 mg/kg/day for 5 days), rats showed an enhanced locomotor response to an amphetamine challenge. Mifepristone (20 mg/kg) given 45 min prior to the challenge completely prevented the expression of amphetamine hyperresponsiveness. The glucocorticoid antagonist did not affect the locomotor response to amphetamine in drug-naive rats. These data demonstrate for the first time that glucocorticoid receptor antagonist treatment may prevent long-term hyperreactivity to drugs of abuse in individuals with a drug history.
authors.affiliation: Graduate School Neurosciences Amsterdam, Research Institute Neurosciences Vrije Universiteit, Department of Pharmacology, Free University, Medical Faculty, Netherlands.
authors.forename: T J
authors.initials: TJ
authors.lastname: De Vries
authors.forename: A N
authors.initials: AN
authors.lastname: Schoffelmeer
authors.forename: G H
authors.initials: GH
authors.lastname: Tjon
authors.forename: P
authors.initials: P
authors.lastname: Nestby
authors.forename: A H
authors.initials: AH
authors.lastname: Mulder
authors.forename: L J
authors.initials: LJ
authors.lastname: Vanderschuren
mesh_terms: D000661:Amphetamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D006727:Hormone Antagonists / Q000494:pharmacology*; D008297:Male; D015735:Mifepristone / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D011965:Receptors, Glucocorticoid / Q000037:antagonists & inhibitors / Q000187:drug effects / Q000502:physiology
chemical_list: D006727:Hormone Antagonists; D011965:Receptors, Glucocorticoid; D015735:Mifepristone; D000661:Amphetamine