title: Animal models of demyelination.
abstract: In the past year, animal studies on central nervous system demyelination have focused on therapeutic strategies and the functional characterization of T-cells, cytokines, and adhesion molecules. Significant progress has been realized in the treatment of animals with experimentally induced demyelinating disease using glial cell transplants, autoantibodies, cytokines, growth factors, and by inhibiting adhesion molecules and cytokines. In this review, we summarize the important contributions made in those respective areas.
authors.affiliation: Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: M K
authors.initials: MK
authors.lastname: Njenga
authors.forename: M
authors.initials: M
authors.lastname: Rodriguez
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D003711:Demyelinating Diseases / Q000503:physiopathology*; D004195:Disease Models, Animal; D008959:Models, Neurological
chemical_list: D001324:Autoantigens; D016207:Cytokines