[The effect of the alpha-adrenoblocker tropafen on the microcirculation and the hematocrit index in the capillaries of rats with ischemia].
The ischemia-induced decrease of the hematocrit index was the greatest in precapillaries and smallest capillaries. Significant oscillations of the index occurred in reperfusion. Tropafen decreased the index. Applied prior to ischemia, tropafen did not affect microcirculation and redistribution of erythrocytes during ischemia and reperfusion.
Khugaeva
V K
VK
Aleksandrov
P N
PN
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D002196:Capillaries / Q000187:drug effects / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D006400:Hematocrit; D007511:Ischemia / Q000503:physiopathology*; D008297:Male; D008643:Mesentery / Q000098:blood supply*; D008833:Microcirculation / Q000187:drug effects / Q000503:physiopathology; D051381:Rats; D013997:Time Factors; D014326:Tropanes / Q000494:pharmacology*
D000317:Adrenergic alpha-Antagonists; D014326:Tropanes; C009599:tropodifene