title: [Concentration of adenine nucleotides in blood of predialysis patients with chronic renal failure].
abstract: Intraerythrocyte and blood level ATP concentration is increased in CRF. But little is known on the blood concentration of ADP and AMP in CRF. HPLC was applied to evaluate the ATP, ADP, AMP concentration in blood of 25 CRF patients, with serum creatinine from 2.4 mg/dl to 14.4 mg/dl treated conservatively. Controls were healthy people, with normal renal function. In CRF ATP was higher (p < 0.001) and ADP, AMP and hypoxanthine were lower (p < 0.001) then in controls. Also ATP correlated (r = 0.78; p < 0.001) with serum phosphate and (r = 0.40; p < 0.05) with serum creatinine in CRF patients. Adenine nucleotides turnover is increased in CRF and this process is related to severity of the disease.
authors.affiliation: Z Kliniki Chorób Nerek Akademii Medycznej w Gdańsku.
authors.forename: B
authors.initials: B
authors.lastname: Bułło
authors.forename: M
authors.initials: M
authors.lastname: Marlewski
authors.forename: J
authors.initials: J
authors.lastname: Manitius
authors.forename: R T
authors.initials: RT
authors.lastname: Smoleński
authors.forename: B
authors.initials: B
authors.lastname: Rutkowski
mesh_terms: D000244:Adenosine Diphosphate / Q000097:blood*; D000249:Adenosine Monophosphate / Q000097:blood*; D000255:Adenosine Triphosphate / Q000097:blood*; D000328:Adult; D000368:Aged; D002851:Chromatography, High Pressure Liquid; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D019271:Hypoxanthine / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
chemical_list: D019271:Hypoxanthine; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D003404:Creatinine