Cyclosporin A mouthwash in the treatment of oral lichen planus.
Seven patients with long-standing atrophic/erosive oral lichen planus were treated for 4 weeks with cyclosporin A as a mouthwash. At the end of the 3-month follow-up period, no improvement in disease status was noted in any of the patients, although two patients showed a slight improvement of their lesions at the end of 1 month of treatment. Cyclosporin A as a mouthwash does not seem to be an effective means of treating severe oral lichen planus.
Jungell
P
P
Department of Oral and Maxillofacial Surgery, University of Helsinki, Finland.
Malmstrom
M
M
D000368:Aged; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005882:Gingival Diseases / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D017676:Lichen Planus, Oral / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000187:drug effects; D009067:Mouthwashes; D014060:Tongue Diseases / Q000188:drug therapy
D007166:Immunosuppressive Agents; D009067:Mouthwashes; D016572:Cyclosporine