[The mechanism of the anticonvulsive effect of the delta sleep-inducing peptide under conditions of elevated oxygen pressure].
Delta-sleep-inducing peptide (DSIP) exerted a protective effect against seizures, the effect depending on the DSIP ability to create an optimal ratio between inhibitory and excitatory amino acid neurotransmitters. Administration of the DSIP dramatically increased the contents of gamma-aminobutyric acid and homocarnosine while decreasing the glutamate and aspartate contents in the rat brain cortex.
Mendzheritskiĭ
A M
AM
Lysenko
A V
AV
Uskova
N I
NI
Sametskiĭ
E A
EA
D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology*; D001273:Atmosphere Exposure Chambers; D001923:Brain Chemistry / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology; D003701:Delta Sleep-Inducing Peptide / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004567:Electrodes, Implanted; D006931:Hyperbaric Oxygenation / Q000009:adverse effects*; D008297:Male; D051381:Rats; D012640:Seizures / Q000209:etiology / Q000517:prevention & control
D000927:Anticonvulsants; D003701:Delta Sleep-Inducing Peptide