title: Xenobiotic metabolism genes and the risk of recurrent spontaneous abortion.
abstract: We examined the relation between spontaneous abortion and polymorphisms in two genes, glutathione S-transferase (GSTM1) and N-acetyltransferase (NAT2), which are involved in the metabolism of xenobiotics. In a case-control study of 29 women, we found that, among women with the GSTM1 null genotype, the odds ratio (OR) was 3.1 [95% confidence interval (CI) = 1.3-7.0]. There was less evidence of a relation with NAT2 [Mantel-Haenszel adjusted OR (ORMH) = 1.4; 95% CI = 0.45-4.3]. We sought to replicate the GSTM1 finding in an independent case-control study from New York involving 89 cases. We found an inverse association (OR = 0.8; 95% CI = 0.4-2.4). Taken together, these data provide little evidence of an association between GSTM1 or NAT2 genotype and risk of spontaneous abortion.
authors.affiliation: Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
authors.forename: A
authors.initials: A
authors.lastname: Hirvonen
authors.forename: J A
authors.initials: JA
authors.lastname: Taylor
authors.forename: A
authors.initials: A
authors.lastname: Wilcox
authors.forename: G
authors.initials: G
authors.lastname: Berkowitz
authors.forename: B
authors.initials: B
authors.lastname: Schachter
authors.forename: C
authors.initials: C
authors.lastname: Chaparro
authors.forename: D A
authors.initials: DA
authors.lastname: Bell
mesh_terms: D000026:Abortion, Habitual / Q000201:enzymology / Q000235:genetics*; D000328:Adult; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D044383:Black People / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D007527:Isoenzymes / Q000235:genetics*; D009657:North Carolina; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics; D011247:Pregnancy; D012306:Risk; D044465:White People / Q000235:genetics; D015262:Xenobiotics / Q000493:pharmacokinetics*; D001741:Black or African American
chemical_list: D007527:Isoenzymes; D015262:Xenobiotics; D001191:Arylamine N-Acetyltransferase; D005982:Glutathione Transferase