Use of stents covered with polytetrafluoroethylene in experimental abdominal aortic aneurysm.
OBJECTIVE
To establish the effectiveness of covered stents in the treatment of aortic aneurysms, to investigate the histopathologic healing patterns of the device, and to determine the long-term endurance and integrity of modified polytetrafluoroethylene (PTFE).


METHODS
Experimental aneurysms were created in dogs by enlarging the aortic lumen with a patch of abdominal fascia. After 5 months, eight animals underwent an endoluminal bypass. The bypass device consisted of a 6-cm-long stent covered with thin PTFE. After surgery, the animals were killed at 3, 6, and 12 months in groups of three, three, and two, respectively. Specimens were processed for luminal surface studies and cross-sectional histologic study. Explanted PTFE material was analyzed for its physical characteristics and performance and was compared with retained control samples.


RESULTS
Before the animals were killed, aortography showed patent bypass conduits in all animals, although two of eight had leaks into the aneurysmal sac. Endothelialized neointima largely covered the luminal surface of the PTFE stent. The percentage of prosthetic surface covered by tissue did not change from 3 months to 1 year. Physical testing of the explanted PTFE material showed no structural deterioration and no change in the internodal distance. Thickness and axial tensile strength varied 12% and 17% from controls, respectively.


CONCLUSIONS
Thin-walled PTFE seems to have physicochemical characteristics that make this material adequate for endovascular use. Though limited, this study supports the establishment of preliminary clinical evaluation of metallic stents combined with PTFE for the treatment of abdominal aortic aneurysm.
Palmaz
J C
JC
Section of Cardiovascular and Special Interventions, University of Texas Health Science Center at San Antonio 78284-7800, USA.
Tio
F O
FO
Laborde
J C
JC
Clem
M
M
Rivera
F J
FJ
Murphy
K D
KD
Encarnacion
C E
CE
D000818:Animals; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging / Q000473:pathology; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D001027:Aortography; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004285:Dogs; D004867:Equipment Design; D005500:Follow-Up Studies; D008422:Materials Testing; D008670:Metals / Q000737:chemistry; D011138:Polytetrafluoroethylene / Q000737:chemistry; D015607:Stents; D013499:Surface Properties; D013718:Tensile Strength; D014945:Wound Healing
D008670:Metals; D011138:Polytetrafluoroethylene