title: Increased frequency of apolipoprotein epsilon 2 allele in non-insulin dependent diabetic (NIDDM) patients with nephropathy.
abstract: The genetic polymorphism of apolipoprotein E (epsilon 2, epsilon 3 and epsilon 4) is associated with lipid abnormalities. It has been suggested that lipid abnormalities may contribute to the development and progression of kidney diseases, including diabetic nephropathy. Thus, in this study we compared the apo E allele frequencies among 146 non-insulin-dependent diabetic (NIDDM) patients with nephropathy, 135 NIDDM patients without nephropathy and 576 of the general Japanese population. The epsilon 2 allele frequency was significantly higher in diabetic patients with nephropathy (7.2%) and with renal failure (9.7%) than in diabetic patients without nephropathy (2.6%) and in the general Japanese population (3.7%). It is concluded that there is a possibility that the epsilon 2 allele is associated with nephropathy in NIDDM.
authors.affiliation: Second Department of Internal Medicine, Asahikawa Medical College, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Eto
authors.forename: K
authors.initials: K
authors.lastname: Horita
authors.forename: A
authors.initials: A
authors.lastname: Morikawa
authors.forename: H
authors.initials: H
authors.lastname: Nakata
authors.forename: M
authors.initials: M
authors.lastname: Okada
authors.forename: M
authors.initials: M
authors.lastname: Saito
authors.forename: M
authors.initials: M
authors.lastname: Nomura
authors.forename: A
authors.initials: A
authors.lastname: Abiko
authors.forename: Y
authors.initials: Y
authors.lastname: Iwashima
authors.forename: A
authors.initials: A
authors.lastname: Ikoda
mesh_terms: D000483:Alleles; D053329:Apolipoprotein E2; D001057:Apolipoproteins E / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D010641:Phenotype
chemical_list: D053329:Apolipoprotein E2; D001057:Apolipoproteins E