title: Influence of experimental rat model of multiple organ dysfunction on cefepime and amikacin pharmacokinetics.
abstract: We adapted an experimental model of multiple organ dysfunction to study the alterations it induces in the pharmacology of cefepime and amikacin. The half-lives of both antibiotics were significantly prolonged because of nonsignificant enhancement of the volume of distribution and reduced renal elimination. In the presence of multiple organ dysfunction, the concentration of each antibiotic in the lungs, compared with that in the lungs of healthy controls, was significantly decreased, despite similar concentrations in plasma, indicating that the application of a standard antibiotic concentration in plasma could lead to underdosage in tissues during the initial days of therapy.
authors.affiliation: Service d'Anesthésie-Réanimation Chirurgicale, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
authors.forename: O
authors.initials: O
authors.lastname: Mimoz
authors.forename: A
authors.initials: A
authors.lastname: Jacolot
authors.forename: C
authors.initials: C
authors.lastname: Padoin
authors.forename: J
authors.initials: J
authors.lastname: Quillard
authors.forename: M
authors.initials: M
authors.lastname: Tod
authors.forename: K
authors.initials: K
authors.lastname: Louchahi
authors.forename: K
authors.initials: K
authors.lastname: Samii
authors.forename: O
authors.initials: O
authors.lastname: Petitjean
mesh_terms: D000583:Amikacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002511:Cephalosporins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006207:Half-Life; D008168:Lung / Q000378:metabolism; D009102:Multiple Organ Failure / Q000097:blood / Q000378:metabolism*; D051381:Rats; D000097572:Cefpirome
chemical_list: D000583:Amikacin; D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000097572:Cefpirome