Anti-red blood cell autoantibody transgenic mice: murine model of autoimmune hemolytic anemia.
We established an anti-red blood cell (RBC) autoantibody transgenic mouse line, in which almost all B cells were deleted in the periphery. A small number of B-1 cells, however, escaped from deletion, survived and expanded in the peritoneal cavity and the gut, because of the absence of RBC. The activation of B-1 cells by enteric bacteria induced autoimmune hemolytic anemia (AIHA). In turn, AIHA was cured by elimination of peritoneal B-1 cells. This Tg mouse line is useful for revealing the generation and activation of B-1 cells, and for clarifying the physiological and pathological roles of B-1 cells.
Murakami
M
M
Department of Medical Chemistry, Kyoto University, Japan.
Honjo
T
T
D000744:Anemia, Hemolytic, Autoimmune / Q000209:etiology*; D000818:Animals; D001323:Autoantibodies / Q000235:genetics / Q000502:physiology*; D001402:B-Lymphocytes / Q000502:physiology*; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D018928:Immunity, Mucosal; D007422:Intestines / Q000382:microbiology; D008213:Lymphocyte Activation; D051379:Mice; D008822:Mice, Transgenic
D001323:Autoantibodies