No evidence for linkage of chromosome 6p markers to schizophrenia in southern African Bantu-speaking families.
Previous studies have yielded evidence for a locus conferring susceptibility to schizophrenia and schizophrenia spectrum disorders on chromosome 6p24-22 in a sample of multiply affected Irish families. We tested for linkage between highly polymorphic chromosome 6p24-22 markers and narrowly defined schizophrenia in a sample of 19 Southern African Bantu-speaking families, a population known to have diverged in the last 2000 years. There is no evidence to support the linkage of markers in this region of chromosome 6 to schizophrenia in this population.
Riley
B P
BP
Department of Biochemistry and Molecular Genetics, St Mary's Hospital Medical School, Imperial College, London, UK.
Rajagopalan
S
S
Mogudi-Carter
M
M
Jenkins
T
T
Williamson
R
R
D044383:Black People / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6; D003198:Computer Simulation; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*; D013019:South Africa / Q000453:epidemiology
D005819:Genetic Markers