Prevention by cycloheximide of the audiogenic seizures and tryptophan metabolic disturbances of ethanol withdrawal in rats.
Cycloheximide (20 mg/kg body wt, given intraperitoneally at-1 and 3 h after withdrawal of an ethanol-containing liquid diet) prevents the activation of liver tryptophan pyrrolase, the consequent inhibition of synthesis of brain 5-hydroxytryptamine, and the audiogenic seizures observed at 7 h after alcohol withdrawal. We suggest that a rapidly-turning-over protein mediates the alcohol withdrawal syndrome and discuss the possible role of liver tryptophan pyrrolase.
Oretti
R
R
Department of Psychological Medicine, University of Wales College of Medicine, Health Park, Cardiff, UK.
Bano
S
S
Morgan
C J
CJ
Badawy
A A
AA
Bonner
A
A
Buckland
P
P
McGuffin
P
P
D000161:Acoustic Stimulation; D000430:Alcohol Withdrawal Delirium / Q000503:physiopathology* / Q000517:prevention & control; D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000503:physiopathology* / Q000517:prevention & control; D012701:Serotonin / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism*; D014366:Tryptophan Oxygenase / Q000037:antagonists & inhibitors / Q000502:physiology
D011500:Protein Synthesis Inhibitors; D012701:Serotonin; D014364:Tryptophan; D003513:Cycloheximide; D014366:Tryptophan Oxygenase