title: The indoor air and children's health study: methods and incidence rates.
abstract: The Indoor Air and Children's Health Study is a prospective cohort study of the relation between indoor air pollution and lower respiratory illness (LRI) during the first 2 years of life. Information on family and household characteristics was obtained from a health maintenance organization for 1,424 infants enrolled at birth. Data on LRI were abstracted from medical records. The incidence of all LRI was 48.4 per 100 child-years. Wheezing-associated respiratory illness (WARI)/asthma was the most common specific LRI, with an incidence of 11.5 per 100 child-years. Total LRI incidence was lowest during the first 6 months of life. Girls had lower incidence than boys [rate ratio (RR) = 0.8; 95% confidence interval (CI) = 0.7-0.8)]. With the exception of croup, all LRI were most common during February and March. These results are comparable with those of other prospective studies. Consistent with other studies, self-reported maternal smoking demonstrated an RR of 1.5 (95% CI = 1.2-1.8) for total LRI, but the association varied for specific LRIs from 2.3 (95% CI = 1.5-3.0) for WARI/asthma to 1.0 (95% CI = 0.7-1.6) for bronchitis.
authors.affiliation: Section of Chronic Disease and Environmental Epidemiology, Minnesota Department of Health, Minneapolis, MN 55414, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Marbury
authors.forename: G
authors.initials: G
authors.lastname: Maldonado
authors.forename: L
authors.initials: L
authors.lastname: Waller
mesh_terms: D016902:Air Pollution, Indoor / Q000009:adverse effects* / Q000706:statistics & numerical data; D001249:Asthma / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D002675:Child, Preschool; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004781:Environmental Exposure / Q000009:adverse effects / Q000706:statistics & numerical data; D005260:Female; D006306:Health Surveys; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008910:Minnesota / Q000453:epidemiology; D011446:Prospective Studies; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000209:etiology* / Q000517:prevention & control; D012306:Risk; D014028:Tobacco Smoke Pollution / Q000009:adverse effects / Q000706:statistics & numerical data
chemical_list: D014028:Tobacco Smoke Pollution