title: How to alter the bacterial genome structure.
abstract: Bacterial chromosomes, mostly of circular form, have an unique primary structure that are stably maintained. We initiated a systematic study to induce changes of the structure of the Bacillus subtilis chromosome. There are two main goals: (i) to obtain general concepts for possible plasticity of the bacterial genome and (ii) to apply the proposed genome technology to bacteria.
authors.affiliation: Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Itaya
authors.forename: T
authors.initials: T
authors.lastname: Toda
authors.forename: Y
authors.initials: Y
authors.lastname: Ohshiro
authors.forename: M
authors.initials: M
authors.lastname: Ogura
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D001412:Bacillus subtilis / Q000187:drug effects / Q000235:genetics; D002876:Chromosomes, Bacterial / Q000235:genetics*; D004269:DNA, Bacterial / Q000235:genetics; D004352:Drug Resistance, Microbial / Q000235:genetics; D015321:Gene Rearrangement; D016680:Genome, Bacterial; D015394:Molecular Structure; D011995:Recombination, Genetic
chemical_list: D004269:DNA, Bacterial