[Antioxidant effect of metallothioneins in acute bromobenzene poisoning in mice].
An increase in the content of malondialdehyde (MDA) and endogenous metallothioneins (MT) in the liver of mice 1 day after intraperitoneal injection of bromobenzene (0.5-2 g/kg) has been found. An exogenic zinc-MT polymer injected to mice decreases the basal and xenobiotic-induced MDA level in the liver and blood plasma and decreases the acute toxicity of bromobenzene. The mixture modelling zinc-MT composition (albumin, cysteine and zinc) possesses no such properties. A conclusion is made that the protective effect is specific for the MT structure and is induced by antioxidant properties of MT.
Koterov
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D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001481:Basal Metabolism; D001969:Bromobenzenes / Q000506:poisoning*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D008668:Metallothionein / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D015032:Zinc
D000975:Antioxidants; D001969:Bromobenzenes; C021267:zinc thionein; D008315:Malondialdehyde; D008668:Metallothionein; C032036:bromobenzene; D015032:Zinc