Phonologic processing deficits in Alzheimer's disease.
We investigated phonologic production in patients with mild to moderate Alzheimer's disease (AD) on a repetition task. AD patients produced significantly more speech errors than age-matched controls. AD patients' errors, unlike those of controls, resulted in the transformation of real words into pseudowords, occurred disproportionately in word-initial positions, and were not influenced by the phonologic environment. This pattern of errors suggests a lexical phonologic retrieval deficit in AD.
Biassou
N
N
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA.
Grossman
M
M
Onishi
K
K
Mickanin
J
J
Hughes
E
E
Robinson
K M
KM
D'Esposito
M
M
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D012016:Reference Values; D013060:Speech; D013064:Speech Disorders / Q000209:etiology* / Q000523:psychology