title: Determination of the enantiomeric composition of mexiletine and its four hydroxylated metabolites in urine by enantioselective capillary gas chromatography.
abstract: The enantiomers of mexiletine and four of its hydroxylated metabolites were directly separated by capillary gas chromatography using a heptakis(6-O-tert-butyl-dimethylsilyl-2,3-di-O-methyl)-beta- cyclodextrin column. The method was applied to the analysis of urine samples from cancer patients who were treated with racemic mexiletine as part of a study of the use of mexiletine in the relief of neuropathic pain. Samples analyzed before and after deconjugation of the urine with beta-glucuronidase/arylsulfatase showed a high stereoselectivity in the formation and conjugation of these compounds.
authors.affiliation: Department of Oncology, McGill University, Quebec, Canada.
authors.forename: B
authors.initials: B
authors.lastname: Knoche
authors.forename: B
authors.initials: B
authors.lastname: Gehrcke
authors.forename: W A
authors.initials: WA
authors.lastname: König
authors.forename: I W
authors.initials: IW
authors.lastname: Wainer
mesh_terms: D002849:Chromatography, Gas; D006801:Humans; D006900:Hydroxylation; D008801:Mexiletine / Q000737:chemistry / Q000493:pharmacokinetics / Q000652:urine*; D013237:Stereoisomerism
chemical_list: D008801:Mexiletine