title: Ontogeny of GABA-immunoreactive cells in the primate cerebellar cortex: comparison with somatostatin-immunoreactivity.
abstract: The distribution and ontogeny of GABA-immunoreactive cells were studied and compared with that of somatostatin-immunoreactivity in the primate cerebellar cortex. At embryonic day 80, we observed neither GABA-nor somatostatin-immunoreactive cells in the cerebellum. At embryonic day 110, a small number of GABA-immunoreactive cells was detectable in the granular layer only, and these cells seemed to be Golgi cells. At embryonic day 140, although almost all Purkinje cells were somatostatin-immunoreactive, a proportion of these cells was GABA-immunoreactive. At the newborn stage, most of the Purkinje cells were GABA-immunoreactive and almost all of them were also somatostatin-immunoreactive. During the postnatal stages, the number of somatostatin-immunoreactive cells decreased until postnatal day 60. At the adult stage, a large number of Purkinje cell bodies was faintly GABA-immunoreactive and a proportion of Purkinje cell dendrites was GABA-immunoreactive. In the aged animals (28 and 31 years old), a small number of Purkinje cell dendrites was GABA-immunoreactive. These findings suggest that a transition of phenotype from somatostatin to GABA occurred in Purkinje cells during development.
authors.affiliation: Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan. akiko@med.nihon-u.ac.jp
authors.forename: A
authors.initials: A
authors.lastname: Yamashita
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D002531:Cerebellum / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D004622:Embryo, Mammalian; D007150:Immunohistochemistry; D008251:Macaca; D008252:Macaca fascicularis; D008253:Macaca mulatta; D011689:Purkinje Cells / Q000502:physiology; D013004:Somatostatin / Q000276:immunology / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis* / Q000276:immunology
chemical_list: D013004:Somatostatin; D005680:gamma-Aminobutyric Acid