High-dose chemotherapy with peripheral blood stem-cell transplantation for hormone-refractory advanced carcinoma of the prostate: experience of two cases.
Two patients with hormone-refractory advanced prostate cancer were treated with high-dose chemotherapy and peripheral blood stem-cell transplantation. A satisfactory number of stem cells were collected by appropriately timed leukapheresis in these patients. The stem-cell samples collected from the first patient were positive for prostate-specific antigen messenger ribonucleic acid expression; such expression was not detected in the samples from the second patient. The first patient has remained in complete remission as of December 1995. The second patient died of the disease.
Nishiyama
T
T
Department of Urology, Koseiren Nagaoka Chuo General Hospital, Japan.
Kishi
K
K
Deguchi
T
T
Mukaiyama
T
T
Terunuma
M
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001773:Blood Cells / Q000637:transplantation*; D002277:Carcinoma / Q000628:therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000628:therapy*; D033581:Stem Cell Transplantation; D013852:Thiotepa / Q000008:administration & dosage
D007987:Gonadotropin-Releasing Hormone; D003520:Cyclophosphamide; D013852:Thiotepa