Bleomycin therapy of experimental disseminated candidiasis in mice.
Bleomycin, an antineoplastic agent, was found to be very effective in vitro against a variety of fungi, including Candida albicans. Mice were infected with C. albicans intravenously and then treated with various doses of bleomycin. No efficacy was shown by either prolongation of survival or reduction of tissue counts.
Graybill
J R
JR
University of Texas Health Science Center, San Antonio 78284, USA.
Bocanegra
R
R
Fothergill
A
A
Rinaldi
M G
MG
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D001761:Bleomycin / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D015169:Colony Count, Microbial; D007668:Kidney / Q000382:microbiology; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D051381:Rats; D013154:Spleen / Q000382:microbiology
D000903:Antibiotics, Antineoplastic; D001761:Bleomycin