Immunological determinants of disease caused by respiratory syncytial virus.
Various disease syndromes caused by respiratory syncytial virus (RSV) may have a common mechanism of pathogenesis mediated by cytokines produced by type 2 T helper cells. The nature of the immune response to RSV is determined by the pattern of cytokines produced sequentially by many different cell types. Vaccination can influence the types of cytokine produced by selectively activating T cell subpopulations and inducing an immune response that clears the virus with minimal immunopathology.
Graham
B S
BS
Dept of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2605, USA. Barney.Graham@mcmail.vanderbilt.edu
D000818:Animals; D002417:Cattle; D016207:Cytokines / Q000378:metabolism; D051379:Mice; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology*; D018113:Respiratory Syncytial Virus, Human / Q000472:pathogenicity*; D006377:T-Lymphocytes, Helper-Inducer / Q000378:metabolism*; D013997:Time Factors; D014765:Viral Vaccines / Q000008:administration & dosage / Q000009:adverse effects*
D016207:Cytokines; D014765:Viral Vaccines