The discovery of a new organic nitrate: an overview.
Organic nitrates have been in therapeutic use for the treatment of angina pectoris for over a century. During the past decade, the search for new organic nitro esters with reduced side effects and improved oral bioavailability has been greatly intensified. We have discovered a new class of organic nitrates characterized by good oral activity and a coronary vascular selectivity greater than that of glyceryl trinitrate. Full structure-activity relationship studies of this new class of nitroesters are reported. From the screening of these compounds, ITF 296 was chosen for further evaluation.
Benedini
F
F
Italfarmaco Research Center, Milan, Italy.
Bertolini
G
G
Gromo
G
G
Mizrahi
J
J
Sala
A
A
D000818:Animals; D048588:Benzoxazines; D006801:Humans; D009566:Nitrates / Q000737:chemistry* / Q000494:pharmacology; D010078:Oxazines / Q000737:chemistry* / Q000494:pharmacology; D014665:Vasodilator Agents / Q000737:chemistry* / Q000494:pharmacology
D048588:Benzoxazines; D009566:Nitrates; D010078:Oxazines; D014665:Vasodilator Agents; C091726:sinitrodil