title: Successful allogeneic bone marrow transplantation for agnogenic myeloid metaplasia in a 3-year-old boy.
abstract: OBJECTIVE
  Agnogenic myeloid metaplasia (AMM) is a myeloproliferative disorder characterized by marrow fibrosis, extramedullary hematopoiesis, splenomegaly, and leukoerythroblastosis with abnormalities of red blood cell morphology. This is rarely encountered in children. No conventional curative therapy is known; however, allogeneic bone marrow transplantation (BMT) may eradicate the underlying stem cell abnormality with subsequent normal hematopoiesis.
  
  
  RESULTS
  We report a 3-year-old Arab boy who had AMM and who had normal marrow hematopoiesis and markedly reduced fibrosis after high-dose chemotherapy and matched sibling BMT.
  
  
  CONCLUSIONS
  Allogeneic BMT offers a potential cure for patients with agnogenic myeloid metaplasia. A preparatory regimen containing busulfan and cyclophosphamide appears promising for patients with the disease.
authors.affiliation: Division of Pediatric Hematology/Oncology, All Children's Hospital, St. Petersburg, Florida 33701, USA.
authors.forename: H C
authors.initials: HC
authors.lastname: Rossbach
authors.forename: N H
authors.initials: NH
authors.lastname: Grana
authors.forename: W
authors.initials: W
authors.lastname: Chamizo
authors.forename: N J
authors.initials: NJ
authors.lastname: Barrios
authors.forename: J L
authors.initials: JL
authors.lastname: Barbosa
mesh_terms: D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D006410:Hematopoiesis / Q000502:physiology; D006801:Humans; D008297:Male; D055728:Primary Myelofibrosis / Q000601:surgery*