title: Leukocyte-endothelial adhesion and angiogenesis in tumors.
abstract: Leukocyte-endothelial adhesion and angiogenesis, until recently considered as separate processes, have been shown to be linked by two recent findings: soluble cellular adhesion molecules (CAMs) involved in leukocyte-endothelial interactions are angiogenic and well known angiogenic molecules secreted by cancer or immune. cells can modulate the endothelial CAMs. This molecular link may partially explain why the overall leukocyte-endothelial interaction is often low and heterogeneous in angiogenic tumor vessels and why activated lymphocytes adhere nonuniformly to tumor vessels when injected into the tumor's blood supply.
authors.affiliation: Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Boston, USA.
authors.forename: R K
authors.initials: RK
authors.lastname: Jain
authors.forename: G C
authors.initials: GC
authors.lastname: Koenig
authors.forename: M
authors.initials: M
authors.lastname: Dellian
authors.forename: D
authors.initials: D
authors.lastname: Fukumura
authors.forename: L L
authors.initials: LL
authors.lastname: Munn
authors.forename: R J
authors.initials: RJ
authors.lastname: Melder
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000502:physiology; D002450:Cell Communication / Q000502:physiology*; D004730:Endothelium, Vascular / Q000166:cytology*; D006801:Humans; D007962:Leukocytes / Q000166:cytology*; D009369:Neoplasms / Q000098:blood supply*; D009389:Neovascularization, Pathologic / Q000473:pathology*
chemical_list: D015815:Cell Adhesion Molecules