[Selective permeability of the glomerular filtration barrier in man].
Glomerular ultrafiltration of macromolecules is a biophysical process sharing both a diffusive and a convective component, governed by glomerular hemodynamics, through a composite structure, the glomerular filtration barrier. Studies of the fractional clearance of macromolecules have showed that transcapillary filtration of macromolecules is hindered by size, electrostatic charge and to a lesser degree by spatial conformation. Several modelizations of ultrafiltration have been developped to quantify the respective role of glomerular hemodynamic and/or membrane structural alternations as found in glomerular diseases.
Petitjean
P
P
Département de néphrologie, Hôpitaux Universitaires de Strasbourg.
Chantrel
F
F
Hannedouche
T
T
D002199:Capillary Permeability; D006801:Humans; D007678:Kidney Glomerulus / Q000098:blood supply*; D011506:Proteins / Q000737:chemistry / Q000378:metabolism
D011506:Proteins