Variations in steroid hormone receptor content throughout age and menopausal periods, and menstrual cycle in breast cancer patients.
Variations in steroid hormone receptor contents throughout age and menopausal periods define three breast carcinoma groups: younger premenopausal carcinomas (aged up to 45), middle-aged carcinomas (pre-, peri- and postmenopausal aged 45-59) and older postmenopausal carcinomas (aged over 59). Age-related steroid hormone receptor contents within premenopausal and postmenopausal carcinoma groups are characterized by the important increase of both receptor contents, while menopausal-related steroid hormone receptor contents within middle-aged carcinoma group (aged 45-59) are characterized by the important decrease of progesterone receptor content and estrogen receptor functionality. No variations in steroid hormone receptor contents throughout menstrual cycle within the follicular and the luteal phases were obtained. The important decrease of estrogen receptor content in the mid-cycle phase versus the perimenstrual phase was found. Variations in steroid hormone receptor contents throughout age and menopausal periods, as well as throughout menstrual cycle could not be associated with variations in the blood steroid hormone concentrations. However, important association between steroid hormone receptor contents and the blood steroid hormone concentrations was found within the luteal phase carcinoma group and within older postmenopausal carcinoma group. It is interesting that within carcinoma group with the highest concentration of progesterone, progesterone receptor content increases with an increase of the ratio of estradiol and progesterone blood concentrations, while within carcinoma group with the lowest steroid hormone concentration and the highest content of estrogen receptor content, estrogen receptor content decreases with an increase of either the blood estradiol concentration or the ratio of the blood estradiol and progesterone blood concentrations.
Nikolić-Vukosavljević
D
D
Institute of Oncology and Radiology of Serbia, Department of Experimental and Clinical Oncology, Belgrade, Yugoslavia.
Vasiljević
N
N
Branković-Magić
M
M
Polić
D
D
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000375:Aging / Q000502:physiology*; D001943:Breast Neoplasms / Q000503:physiopathology*; D004967:Estrogens / Q000097:blood; D005260:Female; D006801:Humans; D008593:Menopause / Q000502:physiology; D008597:Menstrual Cycle / Q000502:physiology*; D008875:Middle Aged; D011374:Progesterone / Q000097:blood; D011960:Receptors, Estrogen / Q000502:physiology*; D011980:Receptors, Progesterone / Q000502:physiology*
D004967:Estrogens; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011374:Progesterone