title: Colonization of a calcium phosphate/elastin-solubilized peptide-collagen composite material by human osteoblasts.
abstract: The evaluation of the suitability of a new biomaterial as a possible substitute for bone tissue is described here. This biomaterial is based on calcium phosphate particles linked to an artificial connective matrix, the elastin-solubilized peptides (ESP) associated with type I and III collagens. This work demonstrates the feasibility of shaping this composite material into discs, describes its microstructural characteristics, and evaluates its capacity as a substrate for the proliferation of human osteoblasts without loss of their phenotypic expression.
authors.affiliation: CIDA (Centro de Investigacion y Desarrollo Aplicado sal) Centro Industrial Santiga, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Rovira
authors.forename: J
authors.initials: J
authors.lastname: Amedee
authors.forename: R
authors.initials: R
authors.lastname: Bareille
authors.forename: M
authors.initials: M
authors.lastname: Rabaud
mesh_terms: D000327:Adsorption; D000469:Alkaline Phosphatase / Q000378:metabolism; D001672:Biocompatible Materials; D015415:Biomarkers; D002455:Cell Division; D003094:Collagen; D004247:DNA / Q000096:biosynthesis; D017886:Durapatite; D004549:Elastin; D006801:Humans; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000166:cytology* / Q000502:physiology*; D015675:Osteocalcin / Q000096:biosynthesis; D015676:Osteonectin / Q000096:biosynthesis; D010446:Peptide Fragments; D013936:Thymidine / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D015415:Biomarkers; D015676:Osteonectin; D010446:Peptide Fragments; D015675:Osteocalcin; D003094:Collagen; D004247:DNA; D004549:Elastin; D017886:Durapatite; D000469:Alkaline Phosphatase; D013936:Thymidine