Antihypertensive and renal effects of acute and chronic therapy with a dihydropyridine Ca-antagonist in patients with different salt sensitivity.
We evaluated the effect of the dihydropyridine Ca-channel blocker nitrendipine on blood pressure (BP) and electrolyte urinary excretion after acute and chronic therapy in 33 patients with different NaCl sensitivity as assessed by a modification of the test of Grim and colleagues. Acute nitrendipine administration significantly reduced BP in the group as a whole, although the hypotensive effect was greater in patients with greater NaCl sensitivity; this difference was still evident after 1 month of chronic therapy. Furthermore, urinary sodium and calcium excretion significantly increased in the 3 h after nitrendipine administration during both acute and chronic therapy: these effects on electrolyte excretion were independent of the NaCl sensitivity of the subject.
Galletti
F
F
Department of Clinical and Experimental Medicine, Federico II, University of Naples Medical School, Italy.
Strazzullo
P
P
Barba
G
G
Ferrara
I
I
Iacone
R
R
Stinga
F
F
Mancini
M
M
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D002118:Calcium / Q000652:urine; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000652:urine; D008297:Male; D008875:Middle Aged; D009568:Nitrendipine / Q000627:therapeutic use*; D012964:Sodium / Q000652:urine; D012965:Sodium Chloride / Q000008:administration & dosage*
D002121:Calcium Channel Blockers; D012965:Sodium Chloride; D009568:Nitrendipine; D012964:Sodium; D002118:Calcium