Sagittal sinus thrombosis in adult minimal change nephrotic syndrome.
Nephrotic syndrome causes a hypercoagulable state, leading to both venous and arterial thrombosis. The mechanisms are as yet unclear, but numerous alterations in coagulant and anti-coagulant factors have been reported [Llach et al. 1985, Harris and Ismail 1994]. The most common clinical features in adults are renal vein thrombosis, femoral vein thrombosis and pulmonary embolism, although thrombosis in numerous other arterial and venous sites has been described [Cameron 1984, Llach et al. 1985]. Intracranial thrombosis is rare, although in adult nephrotic syndrome arterial thrombosis is well recognized [Fuh et al. 1991]. We report a patient with minimal change nephrotic syndrome who developed venous sinus thrombosis detected by magnetic resonance (MR) scanning.
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Department of Medicine, Hammersmith Hospital, London, UK.
Pusey
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D000328:Adult; D003392:Cranial Sinuses; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D009402:Nephrosis, Lipoid / Q000150:complications*; D012851:Sinus Thrombosis, Intracranial / Q000175:diagnosis / Q000209:etiology*