Increased expression of NLRR-3 mRNA after cortical brain injury in mouse.
In Drosophila, members of the leucine-rich repeat (LRR) family have significant functions in neural development. We have isolated mouse brain cDNAs which encode three new independent LRR proteins (neuronal leucine-rich repeat: NLRR-1, NLRR-2, NLRR-3). Levels of expression of these NLRR mRNAs were measured in a unilateral cortical injury model by in-situ hybridization and Northern blot analysis. In the injured cerebral cortex, only NLRR-3 mRNA increased in layers 2-3, while the other two genes showed no up-regulation. The level of NLRR-3 mRNA induction peaked around 7-10 days postinjury. This study suggests that NLRR-3 may be an important component of the pathophysiological response to brain injury.
Ishii
N
N
Department of Anatomy and Neuroscience, Osaka University Medical School, Japan.
Wanaka
A
A
Tohyama
M
M
D000818:Animals; D001921:Brain / Q000378:metabolism*; D001930:Brain Injuries / Q000378:metabolism*; D002540:Cerebral Cortex; D004330:Drosophila; D017403:In Situ Hybridization; D008562:Membrane Glycoproteins; D051379:Mice; D008813:Mice, Inbred ICR; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D015347:RNA Probes; D012333:RNA, Messenger / Q000096:biosynthesis; D013997:Time Factors; D014158:Transcription, Genetic
C102717:Lrrn3 protein, mouse; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D015347:RNA Probes; D012333:RNA, Messenger