title: Occupational asthma induced by aniseed.
abstract: This report deals with clinical and immunologic studies in a butcher with work-related asthma. Both the positive methacholine inhalation test and the significant changes observed in PEFR measurements supported the diagnosis of asthma. The significant fall observed in PEFR measurements when the patient handled aniseed supported the diagnosis of occupational asthma. Skin prick tests carried out with 13 spices showed positive reactions only to aniseed extract. The patient had high levels of specific antianiseed IgE antibodies. The bronchial challenge test with an aniseed extract showed an immediate response without a late response. These findings suggest that the respiratory symptoms in our patient were induced by the inhalation of aniseed dust through an IgE-mediated immunologic mechanism of immediate hypersensitivity. This study established the diagnosis of occupational asthma from aniseed dust sensitization.
authors.affiliation: Servicio de Alergología, Hospital Clínico, Universitario Lozano Blesa, Zaragoza, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Fraj
authors.forename: A
authors.initials: A
authors.lastname: Lezaun
authors.forename: C
authors.initials: C
authors.lastname: Colás
authors.forename: F
authors.initials: F
authors.lastname: Duce
authors.forename: M A
authors.initials: MA
authors.lastname: Domínguez
authors.forename: M D
authors.initials: MD
authors.lastname: Alonso
mesh_terms: D000328:Adult; D001249:Asthma / Q000209:etiology* / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D004391:Dust / Q000009:adverse effects; D006801:Humans; D007428:Intradermal Tests; D008297:Male; D009784:Occupational Diseases / Q000209:etiology* / Q000503:physiopathology; D011852:Radioallergosorbent Test; D012639:Seeds / Q000276:immunology; D017365:Spices / Q000009:adverse effects*
chemical_list: D004391:Dust