[Pulmonary nitric oxide synthase isoform expression and their functional significance].
Nitric oxide (NO), discovered as an endothelium derived relaxing factor, is generated during conversion of L-arginine to L-citrulin by nitric oxide synthase (NOS). Now, genes for three isoforms of NOS (nNOS, eNOS, and iNOS) have been cloned and pulmonary expressions of these NOS isoforms have been studied extensively. Localization of these NOS isoforms in the lung and their functional roles are discussed.
Munakata
M
M
First Department of Medicine, Hokkaido University.
D000818:Animals; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism* / Q000502:physiology*; D008168:Lung / Q000201:enzymology*; D019001:Nitric Oxide Synthase / Q000235:genetics / Q000378:metabolism* / Q000502:physiology*
D007527:Isoenzymes; D019001:Nitric Oxide Synthase