title: Energy expenditure in rhesus monkeys (Macaca mulatta) during spaceflight using doubly labeled water (2H2(18)O).
abstract: The mean daily energy expenditure rates of three rhesus monkeys (Macaca mulatta) were determined during spaceflight on the joint US-Russian Cosmos 2044 and 2229 missions by the doubly labeled water (2H2(18)O) method. In-flight values were compared with ground data obtained from seven measurements taken from six chair-adapted control monkeys. The mean energy expenditure for the ground control determinations was 94.5 +/- 6.4 kcal.kg-1.day-1 (n = 6). The mean in-flight energy expenditure, 55.1 +/- 8.0 kcal.kg-1.day-1 (n = 3), was significantly less than the mean ground control value (P < 0.05). These data suggest that energy expenditure in restrained rhesus monkeys is significantly reduced during spaceflight.
authors.affiliation: Section of Neurobiology, Physiology, and Behavior, University of California, Davis 95616-8519, USA.
authors.forename: T P
authors.initials: TP
authors.lastname: Stein
authors.forename: M A
authors.initials: MA
authors.lastname: Dotsenko
authors.forename: V I
authors.initials: VI
authors.lastname: Korolkov
authors.forename: D W
authors.initials: DW
authors.lastname: Griffin
authors.forename: C A
authors.initials: CA
authors.lastname: Fuller
mesh_terms: D000818:Animals; D001834:Body Water / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D017666:Deuterium Oxide / Q000378:metabolism; D004032:Diet; D004734:Energy Metabolism / Q000502:physiology*; D006112:Gravitation; D007553:Isotope Labeling; D008253:Macaca mulatta; D008297:Male; D010103:Oxygen Isotopes; D012149:Restraint, Physical; D013026:Space Flight
chemical_list: D010103:Oxygen Isotopes; D017666:Deuterium Oxide