Interaction of oligonucleotides containing anthraquinone at the 2'-sugar position with complementary nucleic acids.
Oligonucleotide 15-mers containing 2-anthraquinonylmethyl substituents at the different 2'-sugar residues have been synthesized. These oligomers exhibit increased stability in formation of hybrids with complementary DNA and RNA without loss of sequence specificity.
Mitsui
T
T
Department of Applied Chemistry, Himeji Institute of Technology, Himeji, Japan.
Yoshioka
J
J
Isuno
T
T
Yamana
K
K
Nakano
H
H
D000880:Anthraquinones / Q000138:chemical synthesis / Q000737:chemistry*; D001483:Base Sequence; D002241:Carbohydrates / Q000737:chemistry; D004355:Drug Stability; D015394:Molecular Structure; D009691:Nucleic Acid Denaturation; D009693:Nucleic Acid Hybridization; D009696:Nucleic Acids / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013816:Thermodynamics
D000880:Anthraquinones; D002241:Carbohydrates; D009696:Nucleic Acids; D009841:Oligonucleotides