'Superwarfarin' poisoning leading to prolonged coagulopathy.
An elderly Chinese was admitted for haemetemesis. Investigations revealed markedly prolonged clotting times that recurred every few days despite administration of fresh frozen plasma and vitamin K. The derangement in coagulation lasted more than 3 months. In view of the absence of liver disease or malabsorption syndromes, long-acting anticoagulant ('superwarfarin') ingestion was suspected. The diagnosis of rodenticide poisoning was hampered by the lack of available assays. Diagnosis of brodifacoum intoxication using HPLC was confirmed only months after prolonged treatment with high dose vitamin K1. Superwarfarin poisoning should be suspected in cases of deranged coagulation refractory to treatment since these over-the-counter rodenticides are easily available.
Hui
C H
CH
Department of Pathology, University of Hong Kong.
Lie
A
A
Lam
C K
CK
Bourke
C
C
D015110:4-Hydroxycoumarins / Q000506:poisoning*; D000368:Aged; D001778:Blood Coagulation Disorders / Q000139:chemically induced* / Q000150:complications; D006801:Humans; D008297:Male; D012378:Rodenticides / Q000506:poisoning*
D015110:4-Hydroxycoumarins; D012378:Rodenticides; C013418:bromfenacoum