Effects of cytogenin on spontaneous arthritis in MRL/1 mice and on pristane-induced arthritis (PIA) in DBA/1J mice.
Cytogenin, 8-hydroxy-3-hydroxymethyl-6-methoxyisocoumarin, has low cytotoxicity on murine and human tumour cells in vitro. It augments or suppresses phagocytosis of macrophages and lymphocyte proliferation. It has been reported that cytogenin has a potent inhibitory effect clinically on adjuvant arthritis in Lewis rats and on type II collagen-induced arthritis in DBA/1J mice. Our experimental findings provide evidence that cytogenin has beneficial effects on spontaneous polyarthritis in MRL/1 mice and pristane-induced arthritis in DBA/1J mice. The results suggest that the mode of the anti-arthritic action of cytogenin is different from those of NSAIDs; although the precise mode of action remains unclear, cytogenin may become an excellent therapeutic agent for rheumatoid arthritis.
Abe
C
C
St. Marianna University School of Medicine, Institute of Medical Sciences, Kanagawa, Japan.
Hirano
S
S
Wakazono
K
K
Mase
T
T
Yamamoto
R
R
Matsufuji
M
M
Sakata
N
N
Agata
N
N
Iguchi
H
H
Ishizuka
M
M
D000818:Animals; D001168:Arthritis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D003374:Coumarins / Q000494:pharmacology; D049934:Isocoumarins; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D013729:Terpenes
D003374:Coumarins; D049934:Isocoumarins; D013729:Terpenes; C066806:cytogenin; C009042:pristane