Cholecystokinin A receptor antagonist inhibits feed memory in Japanese quail.
Cholecystokinin (CCK) modulates learning and memory processes in mammals. The main objective of this work was to study the effect of two cholecystokinin receptor antagonists (CCKA antagonist devazepide and CCKB antagonist PD135158) on feed memory processes in Japanese quail. Memorization of colored food was measured by comparing the feeding behavior of 6- to 8-day-old quails during two successive sessions of 10 min after a 30-min fast in the test box, intersession interval: 24 h. The CCKA antagonist devazepide (0.1 mg/kg, b.wt) injected after the first session appears to disrupt feed memory formation. The CCKB antagonist PD135158 at the same dose induced a similar trend, but no significant effect on feed memorization could be measured. It is suggested that CCKA antagonist inhibits feed memory processes.
Berthelot
V
V
Station de Recherches Avicoles, Institut National de la Recherche Agronomique, Nouzilly, France.
Belzung
C
C
Meunier-Salaun
M C
MC
Nowak
R
R
Picard
M
M
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001570:Benzodiazepinones / Q000494:pharmacology; D002766:Cholecystokinin / Q000378:metabolism; D003370:Coturnix / Q000502:physiology*; D020109:Devazepide; D005247:Feeding Behavior / Q000187:drug effects*; D006727:Hormone Antagonists / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology; D008536:Meglumine / Q000031:analogs & derivatives / Q000494:pharmacology; D008568:Memory / Q000187:drug effects*; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors*
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D006727:Hormone Antagonists; D007211:Indoles; D011949:Receptors, Cholecystokinin; C065600:PD 135158; D008536:Meglumine; D002766:Cholecystokinin; D020109:Devazepide