Anaphylaxis from cow's milk casein.
The case of a 35-year-old woman who suffered anaphylaxis after the ingestion of milk or milk-containing products is presented. Symptoms also appeared after the patient used a cosmetic which contained casein. Skin prick tests, specific IgE measurement, and immunoblotting were carried out with cow's milk extract, and its purified proteins: casein, beta-lactoglobulin, and alpha-lactalbumin. Specific IgE to cow's milk casein was detected with the three tests. Immunoblotting revealed one band of 24 kDa approximately corresponding to the beta-fraction of casein. Negative results to beta-lactoglobulin and alpha-lactalbumin were obtained with the three methods. Symptoms were controlled by rigorous dietary and behavior measures.
Tabar
A I
AI
Sección de Alergología, Hospital Virgen del Camino, Pamplona, Spain.
Alvarez
M J
MJ
Echechipía
S
S
Acero
S
S
Garcia
B E
BE
Olaguíbel
J M
JM
D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced* / Q000276:immunology*; D000818:Animals; D002364:Caseins / Q000009:adverse effects* / Q000276:immunology*; D005260:Female; D006801:Humans; D008892:Milk / Q000276:immunology*
D002364:Caseins