Fatal Candida tropicalis fungaemia in a leukaemic patient receiving fluconazole prophylaxis.
A 50-year-old man with newly diagnosed acute myeloid leukaemia developed breakthrough candidaemia while receiving fluconazole as antifungal prophylaxis during remission-inducing chemotherapy. Candida tropicalis was isolated; the strain was resistant to fluconazole on in vitro sensitivity testing, a phenomenon which has not been previously reported in this setting.
Barnes
A J
AJ
Public Health Laboratory, Withington Hospital, Manchester, U.K.
Wardley
A M
AM
Oppenheim
B A
BA
Morgenstern
G R
GR
Scarffe
J H
JH
Warnock
D W
DW
Johnson
E M
EM
D000935:Antifungal Agents / Q000627:therapeutic use*; D002177:Candidiasis / Q000517:prevention & control*; D004352:Drug Resistance, Microbial; D015725:Fluconazole / Q000627:therapeutic use*; D016469:Fungemia / Q000517:prevention & control*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008297:Male; D008875:Middle Aged
D000935:Antifungal Agents; D015725:Fluconazole