title: More on false thrombocytopenias: EDTA-dependent pseudothrombocytopenia associated with a congenital platelet release defect.
abstract: We report herein the case of a 54-year-old woman with a moderate bleeding tendency, diagnosed as an EDTA-dependent pseudothrombocytopenia associated with a congenital platelet release defect. The patient, at the age of 12, had a misleading diagnosis of idiopathic thrombocytopenic purpura and all the recurrent bleeding problems she had during her life were referred to that disease. The recent correct diagnosis of a false thrombocytopenia stimulated further laboratory investigation on the cause of the patient's bleeding tendency with the consequent identification of a congenital platelet deficiency of the arachidonic acid pathway. This finding is of relevant importance for the management of the patient in case of elective surgery or hemorrhagic emergency.
authors.affiliation: Division of Haematology, University Hospital, Udine, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Silvestri
authors.forename: A
authors.initials: A
authors.lastname: Masotti
authors.forename: P
authors.initials: P
authors.lastname: Pradella
authors.forename: F
authors.initials: F
authors.lastname: Zaja
authors.forename: G
authors.initials: G
authors.lastname: Barillari
authors.forename: L
authors.initials: L
authors.lastname: De Marco
mesh_terms: D016718:Arachidonic Acid / Q000097:blood; D001778:Blood Coagulation Disorders / Q000175:diagnosis*; D001792:Blood Platelets / Q000378:metabolism*; D004492:Edetic Acid; D005260:Female; D006801:Humans; D008875:Middle Aged; D010974:Platelet Aggregation; D013921:Thrombocytopenia / Q000175:diagnosis*
chemical_list: D016718:Arachidonic Acid; D004492:Edetic Acid