[The significance of citrate, uromucoid and GAG for diagnosis of renal tubular acidosis in patients with urinary calculi].
Renal tubular acidosis (type I) is characterized by alterations that lead to disturbed acidification in the tubule. As a result of these alterations, the excretion of uromucoid (formed in the distal tubule), citrate and glycosaminoglycan (GAG) is considerably reduced. There have been numerous investigations on changes in urine pH, citrate and calcium, but few, if any studies on the excretion of uromucoid and GAG. Apart from calcium, phosphate, pH and urease, the present study investigated the excretion of uromucoid, citrate and GAG in a collective of 41 stone patients with renal tubular acidosis (type I). We found that uromucoid excretion was reduced on 90.5%, GAG in 72.2% and citrate in 96% of cases. The reduction of uromucoid excretion in particular is characteristic of RTA I, and it has the function of a marker.
Bichler
K H
KH
Urologische Abteilung der Universität Tübingen.
Henzler
B
B
Strohmaier
W L
WL
Stahl
C
C
Korn
S
S
D000141:Acidosis, Renal Tubular / Q000175:diagnosis* / Q000652:urine; D000643:Ammonium Chloride; D002118:Calcium / Q000652:urine; D002951:Citrates / Q000652:urine*; D006025:Glycosaminoglycans / Q000652:urine*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007669:Kidney Calculi / Q000175:diagnosis* / Q000652:urine; D007677:Kidney Function Tests; D009088:Mucoproteins / Q000652:urine*; D010710:Phosphates / Q000652:urine; D012016:Reference Values; D012189:Retrospective Studies; D058949:Uromodulin
D002951:Citrates; D006025:Glycosaminoglycans; D009088:Mucoproteins; D010710:Phosphates; C548612:UMOD protein, human; D058949:Uromodulin; D000643:Ammonium Chloride; D002118:Calcium