[Helicobacter pylori eradication: triple therapy versus dual therapy].
For the eradication of Helicobacter pylori using dual therapy, the combination of a PPI with clarithromycin is clearly superior to PPI and amoxicillin. At the present time, a modified triple therapy, largely a PPI plus macrolide plus imidazole antibiotics, should be given preference as a cure of Helicobacter pylori infection. The short--one week--duration of the treatment means better tolerability, fewer side-effects and improved patient compliance. The high cure rate achieved with this form of treatment results in a favourable cost-benefit ratio. Overall, this form of therapy should overcome the reservations, still to be found, regarding the use of Helicobacter pylori eradication as optimal treatment of patients with peptic ulcer.
Dammann
H G
HG
KLIFO Hamburg, Wissenschaftliches Institut.
D000658:Amoxicillin / Q000008:administration & dosage; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D001729:Bismuth / Q000008:administration & dosage; D017291:Clarithromycin / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage; D009853:Omeprazole / Q000008:administration & dosage; D010437:Peptic Ulcer / Q000188:drug therapy*; D013752:Tetracycline / Q000008:administration & dosage; D014011:Tinidazole / Q000008:administration & dosage; D016896:Treatment Outcome
D000897:Anti-Ulcer Agents; D014011:Tinidazole; D008795:Metronidazole; D000658:Amoxicillin; D013752:Tetracycline; D017291:Clarithromycin; D009853:Omeprazole; D001729:Bismuth