Value of plasma P-selectin for vascular complications in liver transplantation.
Recent data suggest that plasma P-selectin, an adhesion molecule, may be a clinically useful marker for thrombosis. Hepatic vessel thrombosis is one of the most serious complications following liver transplantation. To assess the contribution of the soluble P-selectin to this complication, we measured plasma P-selectin levels in 32 orthotopic liver transplantations, pre-, intra-, and post-operatively. We found that levels of circulating P-selectin were not different between cirrhotic patients and healthy subjects. Of the 32 patients, 8 had vascular complications. We found a significant increase in the plasma P-selectin concentration in the thrombotic group in early postoperative period compared with the non-thrombotic group (p < 0.002). It measurement may facilitate the diagnosis of thrombosis in the early postoperative period after liver transplantation, and therefore the management of these patients.
Fábrega
E
E
Gastroenterology and Hepatology Unit, University Hospital Marques de Valdecilla, Faculty of Medicine, Santander, Spain.
Casafont
F
F
Merino
J
J
de la Peña
J
J
Crespo
J
J
Amado
J A
JA
Pons-Romero
F
F
D000328:Adult; D015415:Biomarkers / Q000097:blood; D006502:Budd-Chiari Syndrome / Q000097:blood / Q000175:diagnosis; D005260:Female; D006499:Hepatic Artery; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D011169:Portal Vein; D011183:Postoperative Complications; D012372:ROC Curve; D013927:Thrombosis / Q000097:blood / Q000175:diagnosis*
D015415:Biomarkers; D019007:P-Selectin