title: Effects of cytogenin on spontaneous arthritis in MRL/1 mice and on pristane-induced arthritis (PIA) in DBA/1J mice.
abstract: Cytogenin, 8-hydroxy-3-hydroxymethyl-6-methoxyisocoumarin, has low cytotoxicity on murine and human tumour cells in vitro. It augments or suppresses phagocytosis of macrophages and lymphocyte proliferation. It has been reported that cytogenin has a potent inhibitory effect clinically on adjuvant arthritis in Lewis rats and on type II collagen-induced arthritis in DBA/1J mice. Our experimental findings provide evidence that cytogenin has beneficial effects on spontaneous polyarthritis in MRL/1 mice and pristane-induced arthritis in DBA/1J mice. The results suggest that the mode of the anti-arthritic action of cytogenin is different from those of NSAIDs; although the precise mode of action remains unclear, cytogenin may become an excellent therapeutic agent for rheumatoid arthritis.
authors.affiliation: St. Marianna University School of Medicine, Institute of Medical Sciences, Kanagawa, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Abe
authors.forename: S
authors.initials: S
authors.lastname: Hirano
authors.forename: K
authors.initials: K
authors.lastname: Wakazono
authors.forename: T
authors.initials: T
authors.lastname: Mase
authors.forename: R
authors.initials: R
authors.lastname: Yamamoto
authors.forename: M
authors.initials: M
authors.lastname: Matsufuji
authors.forename: N
authors.initials: N
authors.lastname: Sakata
authors.forename: N
authors.initials: N
authors.lastname: Agata
authors.forename: H
authors.initials: H
authors.lastname: Iguchi
authors.forename: M
authors.initials: M
authors.lastname: Ishizuka
mesh_terms: D000818:Animals; D001168:Arthritis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D003374:Coumarins / Q000494:pharmacology; D049934:Isocoumarins; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D013729:Terpenes
chemical_list: D003374:Coumarins; D049934:Isocoumarins; D013729:Terpenes; C066806:cytogenin; C009042:pristane