title: [Prophylaxis of peritoneal carcinomatosis with intraperitoneal administration of cell-adhesion inhibitor, in mice].
abstract: DSD was studied for its prophylactic effect against peritoneal carcinomatosis using B-16 melanoma cell line. In in vitro examinations, incubation in medium containing 0.2% DSD significantly inhibited B-16 melanoma cells from adhering both to the plastic wall and the injured peritoneum, as compared to incubation in normal medium. Upon in vivo examination, intraperitoneal administration of 0.2% of DSD (1 ml/mouse) diminished the cancer cell number implanted into the injured peritoneum more than intraperitoneal administration of DSD-free medium.
authors.affiliation: Dept. of Surgery 1, Kyoto Prefectural University of Medicine.
authors.forename: A
authors.initials: A
authors.lastname: Hagiwara
authors.forename: J
authors.initials: J
authors.lastname: Yamazaki
authors.forename: T
authors.initials: T
authors.lastname: Imanishi
authors.forename: M
authors.initials: M
authors.lastname: Ohgaki
authors.forename: M
authors.initials: M
authors.lastname: Shirasu
authors.forename: C
authors.initials: C
authors.lastname: Sakakura
authors.forename: K
authors.initials: K
authors.lastname: Sawai
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D007263:Infusions, Parenteral; D008297:Male; D008546:Melanoma, Experimental / Q000473:pathology*; D051379:Mice; D010534:Peritoneal Neoplasms / Q000517:prevention & control* / Q000556:secondary*; D011134:Polysaccharides / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D011134:Polysaccharides