Sertraline in the treatment of severe aggressiveness in Huntington's disease.
Sertraline, a selective serotonin reuptake inhibitor, was used to treat two consecutive cases of genetically confirmed Huntington's disease in which severe irritability and aggressiveness required inpatient admission. The complete cessation of aggressive behavior in both cases has been maintained on follow-up. This report adds to the literature implicating serotonergic mechanisms in irritability and aggressiveness in both neuropsychiatric and idiopathic psychiatric disorders.
Ranen
N G
NG
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Lipsey
J R
JR
Treisman
G
G
Ross
C A
CA
D015057:1-Naphthylamine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000328:Adult; D000374:Aggression / Q000187:drug effects* / Q000523:psychology; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000188:drug therapy* / Q000523:psychology*; D007508:Irritable Mood; D008297:Male; D008875:Middle Aged; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D020280:Sertraline
D015057:1-Naphthylamine; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline