title: Local recurrences in giant cell tumour of bone. Long-term follow up of 31 cases.
abstract: We studied the value of histopathological grading in determining the prognosis of giant cell tumour (osteoclastoma) and the rate of local and distant recurrences in a consecutive series of 31 patients. We found that grading had no prognostic value. Eighteen patients were treated by intralesional curettage and 13 by wide excision. Ten patients (56%), who were all treated by curettage, had local recurrences, but none of the tumours with wide excision recurred (p < 0.05). Five (16%) had local recurrences as well as distant metastases, usually to the lungs. The recurrences developed later than an average of 12 years after primary treatment in 3 patients. Wide excision and life-long follow up should be considered in the management of these tumours.
authors.affiliation: Department of Orthopaedic Surgery, Rigshospitalet, University of Copenhagen, Denmark.
authors.forename: G S
authors.initials: GS
authors.lastname: Lausten
authors.forename: P K
authors.initials: PK
authors.lastname: Jensen
authors.forename: T
authors.initials: T
authors.lastname: Schiødt
authors.forename: B
authors.initials: B
authors.lastname: Lund
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000145:classification / Q000473:pathology* / Q000601:surgery; D003646:Debridement; D005260:Female; D005500:Follow-Up Studies; D018212:Giant Cell Tumor of Bone / Q000145:classification / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D013514:Surgical Procedures, Operative / Q000379:methods