Effect of long-term in vivo treatment with imipramine on the oxidative energy metabolism in rat brain mitochondria.
The effects of long-term administration of the tricyclic antidepressant imipramine on energy metabolism of rat brain mitochondria were examined. Intraperitoneal administration of the drug resulted in significant stimulation of the state 3 respiration rates with glutamate, pyruvate+malate, beta-hydroxybutyrate and succinate as the substrates. The effect was evident within a week of imipramine administration and was sustained through the second week of the drug treatment. State 4 respiration rates were also found to be increased in general. However, the respiration with ascorbate+TMPD as the electron donor system decreased. The intramitochondrial content of cytochrome b and c+c1 increased in the first week of the drug treatment; that of aa3 cytochrome increased only in the second week.
Katyare
S S
SS
Department of Biochemistry, M.S. University of Baroda, India.
Rajan
R R
RR
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003580:Cytochromes / Q000187:drug effects / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D007099:Imipramine / Q000494:pharmacology*; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats
D003580:Cytochromes; D007099:Imipramine