Stabilisation of poliovirus with pirodavir.
Two hundred and forty pyridazinamine derivates were assayed for their ability to stabilize the Oral Polio Vaccine (OPV). Of these, pirodavir (R 77975) was selected for vaccine potency tests. Although pirodavir turned out to be an effective stabilizer of OPV, the protection induced by pirodavir was not better, nor additive to the effect by MgCl2 1 M, the usual stabilizer. Both stabilizers were effective in preventing damage to the viral proteins, but could not prevent damage of viral RNA.
Rombaut
B
B
Department of Microbiology and Hygiene, Vrije Universiteit Brussel, Belgium.
Andries
K
K
Boeyé
A
A
D000914:Antibodies, Viral / Q000276:immunology; D000956:Antigens, Viral / Q000737:chemistry / Q000187:drug effects / Q000276:immunology; D002213:Capsid / Q000187:drug effects; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral; D004355:Drug Stability; D004357:Drug Synergism; D006358:Hot Temperature; D015636:Magnesium Chloride / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology*; D017955:Poliovirus / Q000737:chemistry / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D011055:Poliovirus Vaccine, Oral / Q000737:chemistry* / Q000276:immunology; D011310:Preservatives, Pharmaceutical / Q000494:pharmacology*; D011485:Protein Binding; D011487:Protein Conformation; D011489:Protein Denaturation; D011724:Pyridazines / Q000494:pharmacology*; D012367:RNA, Viral / Q000737:chemistry
D000914:Antibodies, Viral; D000956:Antigens, Viral; D010880:Piperidines; D011055:Poliovirus Vaccine, Oral; D011310:Preservatives, Pharmaceutical; D011724:Pyridazines; D012367:RNA, Viral; D015636:Magnesium Chloride; C070921:R 78206; C074589:pirodavir