title: Rhabdomyolysis: an unusual complication of cytotoxic chemotherapy.
abstract: Acute rhabdomyolysis has rarely been reported after cytotoxic chemotherapy, including cytarabine and 5-azacytidine. We observed a case of acute rhabdomyolysis and renal failure after treatment with mitoxantrone and cyclophosphamide. No other cause of muscle injury could be identified, although biochemical analysis of a muscle biopsy specimen revealed a deficiency of muscle phosphorylase activity. Retreatment with doxorubicin and paclitaxel was not associated with recurrent rhabdomyolysis.
authors.affiliation: Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, New York, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Levy
authors.forename: J A
authors.initials: JA
authors.lastname: Sparano
authors.forename: G
authors.initials: G
authors.lastname: Khan
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage; D012206:Rhabdomyolysis / Q000139:chemically induced*
chemical_list: D003520:Cyclophosphamide; D008942:Mitoxantrone