title: Development and expression of hormonal systems regulating aggression.
abstract: There are multiple pathways involved in the regulation of male typical aggression by T, and the functional pathway is determined by genotype. Target-tissue sensitivity to the aggression-promoting properties of T and its estrogenic and androgenic metabolites is determined by a complex sequence of events in which steroid receptors play a critical role. To date, it appears that the relative density of AR may be an important factor in the biobehavioral effects of androgens. Regarding sensitivity to estrogens, characterization of ER-NM interactions, and understanding of the contribution of the two activating functions within ER, appears to be necessary to comprehensively describe the cellular basis for responsiveness to the aggression-promoting effect of this T metabolite. In broader terms, these observations indicate that understanding the relationship between T and the expression of aggression in humans will require models that incorporate cellular aspects of steroid hormone action, including metabolism, receptor function, and gene regulation.
authors.affiliation: Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA.
authors.forename: N G
authors.initials: NG
authors.lastname: Simon
authors.forename: S E
authors.initials: SE
authors.lastname: McKenna
authors.forename: S F
authors.initials: SF
authors.lastname: Lu
authors.forename: A
authors.initials: A
authors.lastname: Cologer-Clifford
mesh_terms: D000374:Aggression / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D005260:Female; D006728:Hormones / Q000378:metabolism*; D008297:Male; D009434:Neural Pathways / Q000502:physiology*; D012737:Sex Factors
chemical_list: D006728:Hormones