A linkage study between bipolar disorder and genes involved in dopaminergic and GABAergic neurotransmission.
Neurobiological studies indicate a dysregulation of the dopaminergic and GABAergic neurotransmission in bipolar disorder. We examined two large families segregating bipolar disorder, for linkage with the genes encoding dopamine beta-hydroxylase, the dopamine transporter DAT1, the dopamine D2, D3 and D5 receptors, and the alpha-1, alpha-5 and beta-1 subunits of the GABAA receptor. Under at least one diagnostic model one of the two families provided evidence to exclude linkage for the DAT1, DRD2, DRD3, DRD5, DBH, GABRA1 and GABARB1 genes but could not exclude the GABRA5 locus. A second family excluded only the GABRA1 and GABRA5 loci at zero recombination and could not formally reject linkage at the DBH, DRD2, DRD3, DRD5, DAT1 and GABARB1 loci. Further analyses at these loci are warranted.
De bruyn
A
A
Neurogenetics Laboratory, Flanders Interuniversity Institute for Biotechnology (VIB), University of Antwerp (UIA), Belgium.
Souery
D
D
Mendelbaum
K
K
Mendlewicz
J
J
Van Broeckhoven
C
C
D001714:Bipolar Disorder / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics; D004298:Dopamine / Q000502:physiology*; D050483:Dopamine Plasma Membrane Transport Proteins; D004299:Dopamine beta-Hydroxylase / Q000235:genetics; D005260:Female; D006801:Humans; D008126:Lod Score; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D010375:Pedigree; D011954:Receptors, Dopamine / Q000235:genetics; D011963:Receptors, GABA-A / Q000235:genetics; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D011954:Receptors, Dopamine; D011963:Receptors, GABA-A; C493214:SLC6A3 protein, human; D005680:gamma-Aminobutyric Acid; D004299:Dopamine beta-Hydroxylase; D004298:Dopamine