title: Urinary excretion of sucrose and fructose as a predictor of sucrose intake in dietary intervention studies.
abstract: The urinary excretion of sucrose, glucose, and fructose was measured in 9 healthy subjects consuming a common Italian diet and after 3 days of a low sucrose diet, in which the intake of sucrose was restricted but the other main nutrients were unmodified. After the low sucrose diet, we observed a significant drop in the average urinary excretion of sucrose, glucose, and fructose determined at four different times (8:00 and 10:00 a.m.; 3:00 and 10:00 p.m.). The average urinary excretion of fructose in the four urine samples was significantly correlated with dietary sucrose intake. We also found a significant correlation between the average urinary excretion of sucrose and dietary sucrose intake. Urinary fructose can be used as a marker of sucrose intake in dietary intervention studies aimed at studying the effect of variation of carbohydrate intake on specific cancers.
authors.affiliation: Department of Pharmacology, University of Florence, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Luceri
authors.forename: G
authors.initials: G
authors.lastname: Caderni
authors.forename: M
authors.initials: M
authors.lastname: Lodovici
authors.forename: M T
authors.initials: MT
authors.lastname: Spagnesi
authors.forename: C
authors.initials: C
authors.lastname: Monserrat
authors.forename: L
authors.initials: L
authors.lastname: Lancioni
authors.forename: P
authors.initials: P
authors.lastname: Dolara
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000652:urine; D003404:Creatinine / Q000652:urine; D004032:Diet; D015930:Diet Records; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D019422:Dietary Sucrose / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D005632:Fructose / Q000008:administration & dosage / Q000652:urine*; D005947:Glucose / Q000008:administration & dosage; D006029:Glycosuria / Q000652:urine; D006801:Humans; D007558:Italy; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D013395:Sucrose / Q000652:urine*; D013997:Time Factors
chemical_list: D015415:Biomarkers; D004040:Dietary Carbohydrates; D019422:Dietary Sucrose; D005632:Fructose; D013395:Sucrose; D003404:Creatinine; D005947:Glucose