Clinical efficacy of itraconazole with initial flucytosine in AIDS-related cryptococcal meningitis: a preliminary study.
This open, prospective study systematically examined the clinical efficacy of itraconazole and initial flucytosine in AIDS-associated cryptococcal meningitis. Clinical as well as mycological responses were evaluated in 10 patients. Satisfactory outcome was achieved in 8 patients (cure in 4 and improvement in 4). In all, 5 patients died, three as a result of cryptococcal meningitis. The remaining 5 patients have been followed for 5-12 months. The treatment proved to be well-tolerated and safe.
Riantawan
P
P
Central Chest Hospital, Department of Communicable Diseases Control, Ministry of Public Health, Nonthaburi, Thailand.
Ponglertnapakorn
P
P
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005437:Flucytosine / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D008297:Male; D016919:Meningitis, Cryptococcal / Q000188:drug therapy*; D011446:Prospective Studies; D016896:Treatment Outcome
D000935:Antifungal Agents; D017964:Itraconazole; D005437:Flucytosine