HLA antigens in an Omani population with dilated cardiomyopathy.
We have investigated the frequency of HLA antigens in 50 Omanis with idiopathic dilated cardiomyopathy to establish whether there are ethnic/racial differences in the reported HLA associations with this disease. There were no statistically significant HLA-A, B, C, DR or DQ antigen frequency differences between the patients and 247 healthy Omanis. THe reported association of HLA-DR4 with idiopathic dilated cardiomyopathy in the Caucasian population does not apply to the Omanis. This confirms the heterogeneity of this disease and points to ethnic/racial origins as important factors when examining the HLA association. This is particularly pertinent as HLD-DR4 has been strongly linked to autoantibody formation in idiopathic dilated cardiomyopathy in Caucasians. The lack of any HLA antigen association in Omanis would argue against the proposed HLA-linked autoimmune pathology of idiopathic dilated cardiomyopathy.
Agarwal
A K
AK
Department of Medicine, College of Medicine, Sultan Qaboos University, Sultanate of Oman.
White
A G
AG
Ali
M
M
Leheny
W A
WA
Daar
A S
AS
D002311:Cardiomyopathy, Dilated / Q000208:ethnology / Q000235:genetics / Q000276:immunology*; D005006:Ethnicity; D006680:HLA Antigens / Q000097:blood*; D006801:Humans; D009850:Oman / Q000453:epidemiology
D006680:HLA Antigens