title: Luminal capsaicin inhibits fluid secretion induced by enterotoxin E. coli STa, but not by carbachol, in vivo in rat small and large intestine.
abstract: The enterotoxin E. coli STa induced fluid secretion in the rat jejunum, ileum and proximal colon in vivo that was greatly inhibited by the co-presence of luminal capsaicin, which is a specific neural toxin of afferent C fibres. The same dose of capsaicin had no effect on the fluid secretion activated by carbachol in the jejunum, ileum and proximal colon. Afferent C fibres appear to be involved in the activation by STa of fluid secretion in the rat intestine in vivo.
authors.affiliation: Faculty of Health and Social Work, Anglia Polytechnic University, Chelmsford, UK.
authors.forename: H C
authors.initials: HC
authors.lastname: Nzegwu
authors.forename: R J
authors.initials: RJ
authors.lastname: Levin
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology*; D002712:Chlorides / Q000378:metabolism; D004768:Enterotoxins / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004926:Escherichia coli; D007419:Intestinal Secretions / Q000187:drug effects* / Q000502:physiology; D009412:Nerve Fibers / Q000187:drug effects / Q000378:metabolism; D009498:Neurotoxins / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002712:Chlorides; D004768:Enterotoxins; D009498:Neurotoxins; D002217:Carbachol; D002211:Capsaicin