title: Cell-mediated immune function and the outcome of chronic fatigue syndrome.
abstract: This study examined the importance of cell-mediated immunity in determining the long-term outcome of patients diagnosed with chronic fatigue syndrome (CSF). A total of 103 patients (74%) of 139 previously enrolled in one of two treatment trials conducted within a university hospital referral center was reviewed a mean of 3.2 yr after trial entry. Ongoing symptom severity, levels of disability and immunological function were assessed at follow-up. The relationship between immunological function at trial entry and measures of outcome was also evaluated. Sixty-five patients (63%) had improved, while only 6 (6%) reported no current symptoms. Thirty-one subjects (30%) were unable to perform any form of work and 26 (25%) were on a disability benefit directly attributable to CFS. Cell-mediated immune function, as measured at trial entry or follow-up, did not appear to affect outcome. Whilst improvement occurred in the majority of patients with CFS, a substantial proportion (37%) remained functionally impaired. Impairment of cell-mediated immunological function measured during the course of the illness may not be an important factor in determining long-term outcome.
authors.affiliation: Department of Psychiatry, Prince Henry Hospital, Little Bay, NSW, Australia.
authors.forename: A
authors.initials: A
authors.lastname: Wilson
authors.forename: I
authors.initials: I
authors.lastname: Hickie
authors.forename: A
authors.initials: A
authors.lastname: Lloyd
authors.forename: D
authors.initials: D
authors.lastname: Hadzi-Pavlovic
authors.forename: D
authors.initials: D
authors.lastname: Wakefield
mesh_terms: D000328:Adult; D000368:Aged; D015673:Fatigue Syndrome, Chronic / Q000276:immunology* / Q000523:psychology / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000523:psychology; D007111:Immunity, Cellular; D008231:Lymphopenia / Q000523:psychology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013601:T-Lymphocytes / Q000276:immunology