Synthesis of oligonucleotides containing a carbocyclic nucleoside.
2'-Bromo-substituted cyclopentane-type carbocyclic nucleoside (7a, 7b) was synthesized from sodium cyclopentadienylide. Subsequently, 7a was incorporated into DNA oligomer by means of a conventional phosphoramidite method. Melting-temperature, CD spectra and chemical reaction of such carbocyclic oligonucleotide are described.
Komeda
Y
Y
Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Japan.
Sakata
K
K
Sugiyama
H
H
Saito
I
I
D001483:Base Sequence; D003517:Cyclopentanes / Q000737:chemistry; D008722:Methods; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry
D003517:Cyclopentanes; D009705:Nucleosides; D009841:Oligonucleotides