Evaluation of selected parameters of a metabolic profile and levels of cadmium in reproductive organs of rabbits after an experimental administration.
Selected serum parameters of metabolic profile and distribution of cadmium in reproductive organs in rabbits were studied after an acute and subchronic administration. After an i.p. application of cadmium (1.5 mg.kg-1) a significant increase of glucose (5.90 mmol.l-1) and cholesterol (2.22 mmol.l-1) was observed. There were no significant differences in these parameters after the subchronic (5 month) p.o. application. The concentration of AST and ALT significantly decreased after a subchronic p.o. administration (1.0 mg.kg-1) but not after an acute i.p. application. There were no significant differences in the level of total proteins and total lipids. The highest accumulation in reproductive organs (testis, ovary, uterus) was observed after i.p. administration. The level in the testis was 40 times higher than in the control group (0.04 mg.kg-1; 1.93 mg.kg-1), 174 times higher in the ovary (0.03; 5.21) and 65 times higher in the uterus (0.04; 2.59). After a subchronic p.o. application, the concentration was only 2.5 times higher in the testis (0.04; 0.10), 16 times higher in the ovary and 6 times higher in the uterus than in the control group.
Massanyi
P
P
University of Agriculture, Nitra, Slovak Republic.
Toman
R
R
Valent
M
M
Cupka
P
P
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001774:Blood Chemical Analysis; D001786:Blood Glucose / Q000378:metabolism; D002104:Cadmium / Q000378:metabolism*; D002105:Cadmium Poisoning / Q000097:blood / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D005260:Female; D008297:Male; D010053:Ovary / Q000378:metabolism*; D011817:Rabbits; D013737:Testis / Q000378:metabolism*; D014599:Uterus / Q000378:metabolism*
D001786:Blood Glucose; D002104:Cadmium; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase