Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human.
The Group IIA phospholipase gene (PLA2G2A) protein coding regions exhibit significant homology with recently described Group IIC (PLA2G2C) and Group V (PLA2GV) genes. All three genes are present in many mammalian species and are expressed in a tissue-specific pattern. Here, we demonstrate in human that they are tightly linked and map to chromosome 1p34-p36.1. We also show that the homologous mouse loci are tightly linked (no observed recombination) on the distal part of chromosome 4, a region exhibiting synteny with human 1p34-p36. Unlike its rodent counterpart, human PLA2G2C appears to be a nonfunctional pseudogene.
Tischfield
J A
JA
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202-5251, USA. JTISCHF@INDYVAX.IUPUI.EDU
Xia
Y R
YR
Shih
D M
DM
Klisak
I
I
Chen
J
J
Engle
S J
SJ
Siakotos
A N
AN
Winstead
M V
MV
Seilhamer
J J
JJ
Allamand
V
V
Gyapay
G
G
Lusis
A J
AJ
D000818:Animals; D001483:Base Sequence; D002118:Calcium; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D003001:Cloning, Molecular; D003433:Crosses, Genetic; D004252:DNA Mutational Analysis; D005091:Exons / Q000235:genetics; D005796:Genes / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D017403:In Situ Hybridization; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009472:Neuronal Ceroid-Lipofuscinoses / Q000235:genetics; D010741:Phospholipases A / Q000235:genetics*; D054467:Phospholipases A2; D012150:Polymorphism, Restriction Fragment Length; D011544:Pseudogenes
D010741:Phospholipases A; D054467:Phospholipases A2; D002118:Calcium