title: Comparison of survival of an expanded polytetrafluoroethylene graft designed for early cannulation to standard wall polytetrafluoroethylene grafts.
abstract: BACKGROUND
  Placement and maintenance of a well-functioning vascular access are essential for delivery of adequate hemodialysis. Newly placed polytetrafluoroethylene (PTFE) arteriovenous grafts require a period of wound healing and incorporation of fibrous tissue before use, a period typically lasting two to three weeks. An ideal PTFE graft would be one that can be used for vascular access immediately, obviating the need for temporary dialysis catheters. Recently an expanded PTFE (ePTFE) graft with a mesh cannulation segment (Diastat graft) has been proposed for early cannulation.
  
  
  METHODS
  This is a retrospective single-center study comparing ePTFE graft survival to contemporaneously placed standard wall PTFE (GORE-TEX) grafts.
  
  
  RESULTS
  Forty-seven consecutive new or established patients receiving chronic hemodialysis had grafts (25 ePTFE, 22 standard PTFE) placed between November 1994 and July 1995. There were no significant differences between the groups in age, race, gender, incidence of diabetes mellitus, or peripheral vascular disease. By the end of the study, 21 of 25 ePTFE grafts had clotted, compared with 11 of the 22 patients receiving a standard PTFE graft. Median time to first clotting was 53 days for the ePTFE grafts and 164 days for the standard PTFE grafts (p < 0.0001). Nine patients with ePTFE grafts required a temporary catheter after their first clotting episode.
  
  
  CONCLUSIONS
  The ePTFE grafts thrombosed at a significantly higher rate than standard wall PTFE grafts. Further experience with the Diastat graft might improve graft survival. However, early experience does not suggest that the avoidance of short-term temporary access outweighs the problem of high clotting rate, and its attendant morbidity.
authors.affiliation: Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110-1093, USA.
authors.forename: D W
authors.initials: DW
authors.lastname: Coyne
authors.forename: J A
authors.initials: JA
authors.lastname: Lowell
authors.forename: D W
authors.initials: DW
authors.lastname: Windus
authors.forename: J A
authors.initials: JA
authors.lastname: Delmez
authors.forename: S
authors.initials: S
authors.lastname: Shenoy
authors.forename: J
authors.initials: J
authors.lastname: Audrain
authors.forename: T K
authors.initials: TK
authors.lastname: Howard
mesh_terms: D001166:Arteriovenous Shunt, Surgical; D001807:Blood Vessel Prosthesis; D001916:Brachial Artery / Q000601:surgery; D002408:Catheters, Indwelling; D005260:Female; D005542:Forearm / Q000098:blood supply; D006083:Graft Occlusion, Vascular / Q000453:epidemiology*; D006085:Graft Survival; D006801:Humans; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D011138:Polytetrafluoroethylene; D011474:Prosthesis Design; D006435:Renal Dialysis; D012189:Retrospective Studies; D013997:Time Factors; D014680:Veins / Q000601:surgery
chemical_list: D011138:Polytetrafluoroethylene