title: The surgical treatment and outcome of pathological fractures in localised osteosarcoma.
abstract: We reviewed the surgical treatment and oncological results of 40 patients with pathological fractures from localised osteosarcoma of the long bones to determine the outcome of limb salvage in their management. All had had adjuvant chemotherapy. There were 26 males and 14 females with a median age at diagnosis of 18 years (2 to 46) and a median follow-up of 55 months (8 to 175). We performed limb salvage in 27 patients and amputation in 13. The margins of resection were radical in five patients, wide in 26, marginal in six, wide but contaminated in two and intralesional in one. Local recurrence developed in 19% of those treated by limb salvage and in none of those who had an amputation. The cumulative five-year survival of all the patients was 57% and in those treated by limb salvage or amputation it was 64% and 47%, respectively (p > 0.05). Limb-sparing surgery with adequate margins of excision can be achieved in many patients with pathological fractures from primary osteosarcoma without compromising survival, but the risk of local recurrence is significant.
authors.affiliation: Royal Orthopaedic Hospital Oncology Service, Royal Orthopaedic Hospital, Northfield, Birmingham, UK.
authors.forename: A
authors.initials: A
authors.lastname: Abudu
authors.forename: N K
authors.initials: NK
authors.lastname: Sferopoulos
authors.forename: R M
authors.initials: RM
authors.lastname: Tillman
authors.forename: S R
authors.initials: SR
authors.lastname: Carter
authors.forename: R J
authors.initials: RJ
authors.lastname: Grimer
mesh_terms: D000293:Adolescent; D000328:Adult; D000671:Amputation, Surgical; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D005260:Female; D005264:Femoral Fractures / Q000150:complications*; D005500:Follow-Up Studies; D005598:Fractures, Spontaneous / Q000209:etiology / Q000601:surgery*; D006801:Humans; D006810:Humeral Fractures / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000150:complications*; D016019:Survival Analysis; D013978:Tibial Fractures / Q000150:complications*; D016896:Treatment Outcome