Role of serotonin3 receptors in prolactin release induced by electroconvulsive therapy: a study with ondansetron.
The effect of pretreatment with odansetron on prolactin (PRL) release induced by electroconvulsive therapy (ECT) was examined in 16 depressive patients in a double-blind, placebo-controlled crossover study. Ten patients were pretreated with 4 mg and the other six with 8 mg of ondansetron. The order of administration of study medication (ondansetron and placebo) was counterbalanced. The failure of ondansetron to attenuate ECT-induced PRL release suggested that serotonin3 receptors are not involved in mediating this response.
Yatham
L N
LN
Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Zis
A P
AP
Lam
R W
RW
Srisurapanont
M
M
McGarvey
K
K
Agbayewa
O
O
D000328:Adult; D018592:Cross-Over Studies; D003866:Depressive Disorder / Q000188:drug therapy* / Q000628:therapy*; D004311:Double-Blind Method; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017294:Ondansetron / Q000494:pharmacology* / Q000627:therapeutic use*; D010919:Placebos; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000187:drug effects*; D012701:Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000494:pharmacology* / Q000627:therapeutic use*
D010919:Placebos; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D012701:Serotonin; D017294:Ondansetron; D011388:Prolactin