title: Renal function during intravenous infusion of urological irrigating fluids in the sheep.
abstract: BACKGROUND
  Oliguria or anuria is an important sign of the transurethral resection syndrome, but the mechanism is not clear.
  
  
  METHODS
  We gave an intravenous infusion of 40 ml/kg of glycine 1.5%, sorbitol 2%-mannitol 1%, and isotonic saline (control) in 6 conscious ewes and studied if irrigating fluids cause acute disturbances of kidney function.
  
  
  RESULTS
  Both the electrolyte-free solutions induced an increase in urine flow and persistent hypo-osmolality. The renal clearances of p-aminohippuric acid and inulin as well as the unilateral renal blood flow, which was measured via ultrasonic flow probes, increased in response to infusion of glycine but not to sorbitol-mannitol. After the infusions, the renal clearances decreased transiently to below baseline levels. Hypertonic saline was given after half of the infusions of electrolyte-free irrigating fluid. This treatment redistributed water from the cells to the extracellular fluid, but had no effect on renal function.
  
  
  CONCLUSIONS
  We conclude that 2500 ml of electrolyte-free irrigating fluid had no detrimental effects on kidney function in sheep. The changes we observed were essentially the same as after infusion of isotonic saline.
authors.affiliation: Department of Physiology, Karolinska Institute, Stockholm, Sweden.
authors.forename: R G
authors.initials: RG
authors.lastname: Hahn
authors.forename: A
authors.initials: A
authors.lastname: Nilsson
authors.forename: H
authors.initials: H
authors.lastname: Hjelmqvist
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Rundgren
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D001825:Body Fluid Compartments / Q000502:physiology; D003404:Creatinine / Q000378:metabolism; D005260:Female; D005998:Glycine / Q000008:administration & dosage; D007262:Infusions, Intravenous; D007444:Inulin / Q000378:metabolism; D007552:Isotonic Solutions / Q000008:administration & dosage; D007668:Kidney / Q000502:physiology*; D008353:Mannitol / Q000008:administration & dosage; D009994:Osmolar Concentration; D011188:Potassium / Q000378:metabolism; D012079:Renal Circulation; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage; D012756:Sheep; D012964:Sodium / Q000378:metabolism; D012965:Sodium Chloride / Q000008:administration & dosage; D013012:Sorbitol / Q000008:administration & dosage; D007507:Therapeutic Irrigation; D014508:Urea / Q000378:metabolism; D014551:Urinary Tract; D010130:p-Aminohippuric Acid / Q000378:metabolism
chemical_list: D001798:Blood Proteins; D007552:Isotonic Solutions; D012462:Saline Solution, Hypertonic; D008353:Mannitol; D012965:Sodium Chloride; D013012:Sorbitol; D014508:Urea; D007444:Inulin; D012964:Sodium; D003404:Creatinine; D011188:Potassium; D005998:Glycine; D010130:p-Aminohippuric Acid