[Prophylaxis of peritoneal carcinomatosis with intraperitoneal administration of cell-adhesion inhibitor, in mice].
DSD was studied for its prophylactic effect against peritoneal carcinomatosis using B-16 melanoma cell line. In in vitro examinations, incubation in medium containing 0.2% DSD significantly inhibited B-16 melanoma cells from adhering both to the plastic wall and the injured peritoneum, as compared to incubation in normal medium. Upon in vivo examination, intraperitoneal administration of 0.2% of DSD (1 ml/mouse) diminished the cancer cell number implanted into the injured peritoneum more than intraperitoneal administration of DSD-free medium.
Hagiwara
A
A
Dept. of Surgery 1, Kyoto Prefectural University of Medicine.
Yamazaki
J
J
Imanishi
T
T
Ohgaki
M
M
Shirasu
M
M
Sakakura
C
C
Sawai
K
K
Takahashi
T
T
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D007263:Infusions, Parenteral; D008297:Male; D008546:Melanoma, Experimental / Q000473:pathology*; D051379:Mice; D010534:Peritoneal Neoplasms / Q000517:prevention & control* / Q000556:secondary*; D011134:Polysaccharides / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D011134:Polysaccharides