Is oral levamisole immunostimulation in rats mediated by reduced levels of free plasma corticosterone?
A brief review of the immunostimulative and anti-inflammatory properties of levamisole is followed by a research report which indicates that in rats under antigenic challenge by ovalbumin, oral levamisole (18 mg/kg) decreases corticosterone levels. This previously unreported finding may belie the immunostimulative effect of levamisole.
Stogaus
R
R
Department of Psychology, University of Newcastle, Callaghan, NSW, Australia.
King
M G
MG
D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000494:pharmacology*; D000284:Administration, Oral; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D003345:Corticosterone / Q000097:blood* / Q000502:physiology; D004435:Eating / Q000187:drug effects; D007978:Levamisole / Q000008:administration & dosage* / Q000276:immunology / Q000494:pharmacology*; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D051381:Rats; D011920:Rats, Inbred WF
D000276:Adjuvants, Immunologic; D007978:Levamisole; D010047:Ovalbumin; D003345:Corticosterone