Rhabdomyolysis: an unusual complication of cytotoxic chemotherapy.
Acute rhabdomyolysis has rarely been reported after cytotoxic chemotherapy, including cytarabine and 5-azacytidine. We observed a case of acute rhabdomyolysis and renal failure after treatment with mitoxantrone and cyclophosphamide. No other cause of muscle injury could be identified, although biochemical analysis of a muscle biopsy specimen revealed a deficiency of muscle phosphorylase activity. Retreatment with doxorubicin and paclitaxel was not associated with recurrent rhabdomyolysis.
Levy
R J
RJ
Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, New York, USA.
Sparano
J A
JA
Khan
G
G
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage; D012206:Rhabdomyolysis / Q000139:chemically induced*
D003520:Cyclophosphamide; D008942:Mitoxantrone