title: Simultaneous squamous cell carcinoma of the head and neck and reticuloendothelial malignancies.
abstract: BACKGROUND
  Multiple primary neoplasms have been reported 4% to 26% of patients with a squamous cell carcinoma (SCC) of the head and neck. The vast majority of these second primaries are SCC and occur in the upper aerodigestive tract; however, head and neck SCC patients are also at higher risk for nonepidermoid neoplasms at any site. Reticuloendothelial malignancies (REM) have been reported in many patients that have SCC of the head and neck as well.
  
  
  METHODS
  Retrospective case series of 5 advanced cases of SCC of the head and neck with synchronous REM.
  
  
  RESULTS
  There was 40% mortality with 19.4 months mean follow-up. Fifty percent of the case had simultaneous cervical involvement with both processes.
  
  
  CONCLUSIONS
  REM can occur simultaneously with SCC of the head and neck and confound staging of nodal status. Head and neck SCC patients are at increased risk for REM secondary to age and treatment factors.
authors.affiliation: Division of Otolaryngology-Head and Neck Surgery, University of South Florida College of Medicine, Tampa, FL 33612, USA.
authors.forename: B C
authors.initials: BC
authors.lastname: Stack
authors.forename: M B
authors.initials: MB
authors.lastname: Ridley
authors.forename: J N
authors.initials: JN
authors.lastname: Endicott
mesh_terms: D000367:Age Factors; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000473:pathology / Q000601:surgery; D002574:Cervical Vertebrae / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000473:pathology / Q000601:surgery; D008297:Male; D008334:Mandible / Q000473:pathology / Q000601:surgery; D008339:Mandibular Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010306:Parotid Gland / Q000473:pathology / Q000601:surgery; D010307:Parotid Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies