Application of the dextran coupling method for analysis of interactions between intercalators and nucleotides.
Water-insoluble intercalators, acridine and pyrene, were converted to water-soluble species, Dex-Pyr and Dex-Acr, respectively, by coupling with dextran polymer. By the use of these dextran-coupled intercalators, interactions of acridine- and pyrene-skeletons with various nucleotides in aqueous solutions were analyzed.
Nakajima
O
O
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Shichita
M
M
Iwasaki
S
S
Hashimoto
Y
Y
D000166:Acridines / Q000737:chemistry; D003911:Dextrans / Q000737:chemistry*; D007364:Intercalating Agents / Q000737:chemistry*; D015394:Molecular Structure; D009711:Nucleotides / Q000737:chemistry*; D011721:Pyrenes / Q000737:chemistry; D012995:Solubility; D014867:Water
D000166:Acridines; D003911:Dextrans; D007364:Intercalating Agents; D009711:Nucleotides; D011721:Pyrenes; D014867:Water; C030984:pyrene