title: [Early intervention for very-low-birth-weight infant].
abstract: In order to establish an early intervention (EI) system for very-low-birth-weight infants, we designed a randomized trial at multiple institutions in Japan. We also reviewed the concept and history of early intervention in USA. Eight medical institutions in different locations were selected for participation. Sixty-two EI group patients and 48 controls without neurological abnormalities (age 2 years) were selected for study. The developmental quotient (DQ) by the revised Kyoto-K method and 15 questionnaire items were monitored twice, at the age of 2 and after one year of EI (3 years). Improvements in behavioral problems, circadian rhythm, and speech were significantly greater in the EI group than in the control group. (P < 0.01). Data on all patients are being collected, and further evaluation and analysis of DQ are planned. The most effective EI method in each specific location and the financial support of its official institutions are required for the success of the EI program for very-low-birth-weight infants.
authors.affiliation: Department of Pediatrics, Kurume University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Matsuishi
authors.forename: S
authors.initials: S
authors.lastname: Ishibashi
authors.forename: Y
authors.initials: Y
authors.lastname: Yamashita
authors.forename: N
authors.initials: N
authors.lastname: Kuriya
authors.forename: Y
authors.initials: Y
authors.lastname: Kamiya
authors.forename: S
authors.initials: S
authors.lastname: Fukuda
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
authors.forename: J
authors.initials: J
authors.lastname: Hara
authors.forename: H
authors.initials: H
authors.lastname: Azuma
authors.forename: J
authors.initials: J
authors.lastname: Shoji
authors.forename: K
authors.initials: K
authors.lastname: Maekawa
mesh_terms: D018479:Early Intervention, Educational / Q000379:methods; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008297:Male