title: Effect of sucralose in coffee on plaque pH in human subjects.
abstract: Our earlier work demonstrated that the sweetener sucralose, C12 H19 CI3 O8, mixed with water had no effect on intraoral plaque pH. The current study compared the effect on resting plaque pH of sucralose to sucrose when these sweeteners were used in hot coffee at equivalent sweetness levels. Twelve subjects with an identified acidogenic plaque were tested at dicrete sessions, using coffee as vehicle with: (1) sucrose; (2) sucralose; (3) sucralose plus maltodextrin (SM); (4) sucralose plus dextrose and maltodextrin (SMD), and (5) no additional sweetener. Each subject rinsed for 1 min with the test rinse, expectorated, and plaque pH was measured at six dental sites for 60 min using an antimony touch electrode method. Data were summarized for baseline pH, delta pH (baseline pH minus lowest pH attained), minimum pH, and area under the pH curve (AUC). Baseline pH was not different throughout all tests. Quantification of AUC in the various groups showed that sucralose with coffee had no statistically significant impact on plaque acidogenesis. AUC, minimum pH and delta pH were least changed by coffee and sucralose, while the SM and SMD combinations generally led to intermediate changes as compared with coffee sweetened with sucrose or sucralose. Because of its acidic nature, unsweetened coffee led to a modest pH depression, the effect of which appears to be blunted by sucralose. This study confirms that sucralose is non-acidogenic and indicates that sucralose may reduce the acidogenic potential of coffee.
authors.affiliation: Center for Clinical Research, Columbia University, School of Dental and Oral Surgery, New York, N.Y., USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Steinberg
authors.forename: F
authors.initials: F
authors.lastname: Odusola
authors.forename: I D
authors.initials: ID
authors.lastname: Mandel
mesh_terms: D000143:Acids / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000368:Aged; D000965:Antimony; D019540:Area Under Curve; D003069:Coffee; D003773:Dental Plaque / Q000378:metabolism / Q000503:physiopathology*; D004566:Electrodes; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008320:Maltose / Q000008:administration & dosage / Q000494:pharmacology; D008875:Middle Aged; D011134:Polysaccharides / Q000008:administration & dosage / Q000494:pharmacology; D013395:Sucrose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D013549:Sweetening Agents / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000143:Acids; D003069:Coffee; D011134:Polysaccharides; D013549:Sweetening Agents; D013395:Sucrose; D008320:Maltose; C008315:maltodextrin; C026285:trichlorosucrose; D000965:Antimony; D005947:Glucose