title: Inhibitory effects of funoran on the adherence and colonization of mutans streptococci.
abstract: Funoran, a sulfated polysaccharide extracted from the seaweed Gloiopeltis furcata strongly inhibited the absorption of mutans streptococci to saliva-coated hydroxyapatite (S-HA), but enhanced that of Streptococcus sanguis ATCC 10556 and Streptococcus oralis ATCC 10557. Furthermore, funoran had a strong desorption activity against mutans streptococci preadsorbed to S-HA. In the presence of sucrose, the absorption of cells of Streptococcus sobrinus B13, Streptococcus mutans Ingbritt, and S. mutans MT8148R to S-HA was strongly inhibited by 0.01% funoran. The colonization of S. sobrinus 6715 inoculated on the molar teeth of experimental rats that were administered funoran was less frequent than that in a funoran-free group. The mean buccal and lingual, sulcal, and total caries scores of rat groups administered funoran were significantly lower than those of the funoran-free group.
authors.affiliation: Department of Bio-Technology, Lotte Central Laboratory Co., Ltd., Saitama, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Saeki
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: Y
authors.initials: Y
authors.lastname: Naito
authors.forename: I
authors.initials: I
authors.lastname: Takazoe
authors.forename: K
authors.initials: K
authors.lastname: Okuda
mesh_terms: D000327:Adsorption; D000818:Animals; D001422:Bacterial Adhesion / Q000187:drug effects*; D002327:Cariostatic Agents / Q000494:pharmacology*; D003731:Dental Caries / Q000382:microbiology; D003773:Dental Plaque / Q000382:microbiology; D017886:Durapatite / Q000737:chemistry; D005260:Female; D006801:Humans; D011134:Polysaccharides / Q000032:analysis / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012463:Saliva; D012624:Seaweed / Q000737:chemistry; D013295:Streptococcus mutans / Q000187:drug effects*; D019533:Streptococcus oralis / Q000187:drug effects; D013298:Streptococcus sanguis / Q000187:drug effects; D016986:Streptococcus sobrinus / Q000187:drug effects*; D013395:Sucrose / Q000494:pharmacology; D013499:Surface Properties; D013501:Surface-Active Agents / Q000494:pharmacology*; D014070:Tooth / Q000382:microbiology
chemical_list: D002327:Cariostatic Agents; D011134:Polysaccharides; D013501:Surface-Active Agents; D013395:Sucrose; C093529:funoran; D017886:Durapatite