Xenobiotic metabolism genes and the risk of recurrent spontaneous abortion.
We examined the relation between spontaneous abortion and polymorphisms in two genes, glutathione S-transferase (GSTM1) and N-acetyltransferase (NAT2), which are involved in the metabolism of xenobiotics. In a case-control study of 29 women, we found that, among women with the GSTM1 null genotype, the odds ratio (OR) was 3.1 [95% confidence interval (CI) = 1.3-7.0]. There was less evidence of a relation with NAT2 [Mantel-Haenszel adjusted OR (ORMH) = 1.4; 95% CI = 0.45-4.3]. We sought to replicate the GSTM1 finding in an independent case-control study from New York involving 89 cases. We found an inverse association (OR = 0.8; 95% CI = 0.4-2.4). Taken together, these data provide little evidence of an association between GSTM1 or NAT2 genotype and risk of spontaneous abortion.
Hirvonen
A
A
Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Taylor
J A
JA
Wilcox
A
A
Berkowitz
G
G
Schachter
B
B
Chaparro
C
C
Bell
D A
DA
D000026:Abortion, Habitual / Q000201:enzymology / Q000235:genetics*; D000328:Adult; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D044383:Black People / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D007527:Isoenzymes / Q000235:genetics*; D009657:North Carolina; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics; D011247:Pregnancy; D012306:Risk; D044465:White People / Q000235:genetics; D015262:Xenobiotics / Q000493:pharmacokinetics*; D001741:Black or African American
D007527:Isoenzymes; D015262:Xenobiotics; D001191:Arylamine N-Acetyltransferase; D005982:Glutathione Transferase