Neuropeptide Y reverses corticotropin-releasing hormone- and psychological stress-caused shortening of sodium pentobarbital-induced sleep in rats.
Intracerebroventricular injection of neuropeptide Y (NPY) prolonged sodium pentobarbital (PhNa)-induced sleep in rats. The prolongation of PbNa-induced sleep by NPY was blocked by naloxone. Both corticotropin-releasing hormone and psychological stress caused shortening of PbNa-induced sleep, and the shortening was reversed by NPY. These results suggest that NPY has a sedative action and that an opioid system in the brain mediates at least in part the action of NPY.
Yamada
K
K
Department of Medicine, Tokyo Women's Medical College, Japan.
Shibasaki
T
T
Tsumori
C
C
Imaki
T
T
Hotta
M
M
Wakabayashi
I
I
Demura
H
H
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D006993:Hypnotics and Sedatives / Q000037:antagonists & inhibitors*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D009478:Neuropeptide Y / Q000494:pharmacology*; D010424:Pentobarbital / Q000037:antagonists & inhibitors*; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects*; D013315:Stress, Psychological / Q000188:drug therapy*; D013997:Time Factors
D006993:Hypnotics and Sedatives; D009292:Narcotic Antagonists; D009478:Neuropeptide Y; D009270:Naloxone; D003346:Corticotropin-Releasing Hormone; D010424:Pentobarbital