title: Carbohydrate-deficient transferrin as a marker of alcohol intake: a study with healthy subjects.
abstract: This paper reports the results of a 3-week drinking experiment in 51 healthy male subjects, examining the value of %CDT (carbohydrate-deficient transferrin) in the context of different levels of alcohol intake. All healthy persons were urine-tested drug-free and underwent daily breath alcohol tests for the 7 days preceding, and during the whole 3 weeks of, the experiment. Subjects were divided into five groups, consuming different amounts of alcohol daily over a 3-h period in the presence of the investigators. The five groups consisted of 10, 9, 10, 16 and 6 subjects respectively and consumed a daily dose of ethanol of 20, 40, 60, 80 and 80 g respectively for 3 weeks. No significant changes in %CDT were detected in most subjects, even in the 80 g alcohol-consuming groups. The results suggest that CDT is not sensitive for the detection of short-term heavy drinking by healthy subjects.
authors.affiliation: Universitätsklinik für Psychiatrie, Wien, Austria.
authors.forename: O M
authors.initials: OM
authors.lastname: Lesch
authors.forename: H
authors.initials: H
authors.lastname: Walter
authors.forename: J
authors.initials: J
authors.lastname: Antal
authors.forename: D E
authors.initials: DE
authors.lastname: Heggli
authors.forename: A
authors.initials: A
authors.lastname: Kovacz
authors.forename: A
authors.initials: A
authors.lastname: Leitner
authors.forename: A
authors.initials: A
authors.lastname: Neumeister
authors.forename: I
authors.initials: I
authors.lastname: Stumpf
authors.forename: E
authors.initials: E
authors.lastname: Sundrehagen
authors.forename: S
authors.initials: S
authors.lastname: Kasper
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000097:blood*; D000437:Alcoholism / Q000175:diagnosis* / Q000201:enzymology; D015415:Biomarkers / Q000032:analysis; D001944:Breath Tests; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D014168:Transferrin / Q000031:analogs & derivatives* / Q000032:analysis; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D015415:Biomarkers; D014168:Transferrin; C056759:carbohydrate-deficient transferrin; D005723:gamma-Glutamyltransferase