title: Massive pulmonary embolism: preliminary results of treatment with the Amplatz thrombectomy device.
abstract: OBJECTIVE
  To determine the feasibility of using the Amplatz thrombectomy device (ATD) to treat massive pulmonary embolism (PE).
  
  
  METHODS
  Five patients (four men, one woman; mean age, 45.2 years) with massive PE underwent mechanical thrombectomy with the ATD, which creates a vortex that pulverizes and recirculates the clots within the pulmonary circulation. The patients were followed up for 7-18 months after thrombectomy.
  
  
  RESULTS
  Marked improvement in pulmonary perfusion was observed in three patients at angiography and ventilation-perfusion scanning. No changes could be assessed in one patient who died shortly after the procedure. One patient developed hemoptysis during the procedure, most likely because of a reperfusion syndrome. A reduction in pulmonary artery pressure was observed in only one patient; the remaining patients had increased pressure. The four surviving patients were discharged within 8 days.
  
  
  CONCLUSIONS
  Mechanical thrombectomy with the ATD provides rapid debulking of thrombus in some patients with massive PE and has the potential to improve treatment and outcomes of the most sick patients.
authors.affiliation: Department of Radiology, Medical University of South Carolina, Charleston 29425, USA.
authors.forename: R
authors.initials: R
authors.lastname: Uflacker
authors.forename: C
authors.initials: C
authors.lastname: Strange
authors.forename: I
authors.initials: I
authors.lastname: Vujic
mesh_terms: D000328:Adult; D000792:Angiography; D001794:Blood Pressure; D002407:Catheterization, Swan-Ganz; D004867:Equipment Design; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006469:Hemoptysis / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery / Q000000981:diagnostic imaging; D011652:Pulmonary Circulation; D011655:Pulmonary Embolism / Q000601:surgery*; D015427:Reperfusion Injury / Q000209:etiology; D015996:Survival Rate; D017131:Thrombectomy / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D016896:Treatment Outcome; D014692:Ventilation-Perfusion Ratio