Central DSP-4 treatment decreases norepinephrine levels and courtship behavior in male zebra finches.
In zebra finches, gonadal steroids activate male courtship, including singing, and also strongly modulate norepinephrine (NE) levels and turnover in brain areas regulating courtship behavior. In a previous study, systemic administration of DSP-4 caused significant decreases in courtship singing. These behavioral decrements were correlated with the degree of NE depletion in several vocal control nuclei. In the present study, we attempted to further decrease brain NE levels while minimizing systemic effects by infusing DSP-4 directly into the third ventricle. DSP-4 treatment significantly reduced NE levels in three of six vocal control nuclei and both hypothalamic nuclei sampled without significantly altering dopamine or serotonin levels in any areas. DSP-4-treated males took longer to begin singing and performed fewer song bouts and courtship displays. Interestingly, behavioral deficits were limited to courtship song displays, other behavior patterns, including female-directed behaviors like approach and follow, were unaffected by DSP-4 treatment. DSP-4 treatment appeared to affect singing behavior by causing deficits in initial attentiveness to females and initiation of singing rather than by affecting song structure.
Barclay
S R
SR
Biopsychology Program, Hunter College, CUNY, NY 10021, USA.
Harding
C F
CF
Waterman
S A
SA
D000818:Animals; D001596:Benzylamines / Q000008:administration & dosage / Q000494:pharmacology*; D001717:Birds / Q000033:anatomy & histology / Q000502:physiology*; D001923:Brain Chemistry / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D003864:Depression, Chemical; D004298:Dopamine / Q000378:metabolism; D004563:Electrochemistry; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D014179:Neurotransmitter Uptake Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D014828:Vocalization, Animal / Q000187:drug effects
D001596:Benzylamines; D014179:Neurotransmitter Uptake Inhibitors; D012701:Serotonin; C012102:DSP 4; D004298:Dopamine; D009638:Norepinephrine