[Human papilloma virus infection and renal transplantation. Two personally observed cases and a review of the literature].
Two cases of recurrent genital infection due to human papilloma virus (HPV) infection with preneoplasic lesions were observed in kidney transplant recipients. The neoplasic component appears to be very frequent in this immunosuppressed population with a risk estimated at 7%. According to the different authors in the literature [correction of litterature], genital lesions due to HPV, with or without dysplasia are found in 15 to 30% of the transplant population. The factors of risk are not different from the general population and are a function of sexual activity. The clinical expression of the lesions, their clinical course and recurrence are probably related to the immunosuppressor treatment. All such patients should be carefully screened to allow prevention and treatment, which, as seen in these cases, may be insufficient to irradicate the lesions. New therapeutic approaches should be studied in this group of patients at risk.
Lefebvre
G
G
Service de Chirurgie Gynécologique et Obstétrique, CHU Pitié-Salpêtrière, Paris.
Darbois
Y
Y
Bitker
M O
MO
Luciani
J
J
Mouquet
C
C
D005260:Female; D005831:Genital Diseases, Female / Q000209:etiology*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D015994:Incidence; D016030:Kidney Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000209:etiology*; D012008:Recurrence; D012307:Risk Factors; D014412:Tumor Virus Infections / Q000209:etiology*