Gangliosides modulate the growth rate and cell phenotype of a murine primitive neuro-ectodermal tumour.
Intratumoural administration of gangliosides (GSD) into a murine primitive neuro-ectodermal tumour, growing in the epicranial subcutaneous tissue of syngenic rats, results in a decrease in the tumour growth rate and causes a more differentiated phenotype of tumour cell, with immunohistochemical expression of neuronal markers. These findings suggest that the potential usefulness of intralesional administration of GSD for the control of tumours of primitive neuro-epithelial character could be considered.
Vaquero
J
J
Neurosurgical Department, Puerta de Hierro Clinic, Autonomous University, Complutensis University, Madrid, Spain.
Zurita
M
M
Oya
S
S
Coca
S
S
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis*; D001921:Brain / Q000187:drug effects / Q000473:pathology; D001932:Brain Neoplasms / Q000139:chemically induced / Q000473:pathology*; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D002455:Cell Division / Q000187:drug effects* / Q000502:physiology; D005038:Ethylnitrosourea; D005732:Gangliosides / Q000494:pharmacology*; D015552:Injections, Intralesional; D009368:Neoplasm Transplantation; D018242:Neuroectodermal Tumors, Primitive / Q000139:chemically induced / Q000473:pathology*; D010641:Phenotype; D051381:Rats; D017208:Rats, Wistar; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000473:pathology
D014408:Biomarkers, Tumor; D005732:Gangliosides; D005038:Ethylnitrosourea