title: The effect of parenteral fish oil on leukocyte membrane fatty acid composition and leukotriene-synthesizing capacity in patients with postoperative trauma.
abstract: The incorporation of omega-3 and omega-6 fatty acids (FAs) into leukocyte membranes and the leukotriene (LT)B4-, LTB5 -, LTC4-, and LTCs-synthesizing capacity in stimulated leukocytes were measured following parenteral omega-3 FA nutrition in 20 postoperative patients. Total parenteral nutrition (TPN) over 5 days postoperatively was isonitrogenous (0.24 g N x kg-1 x d1) and isoenergetic (92 kJ/22 kcal x kg-1 x d-1), containing 0.15 g fish oil and 0.85 g soybean oil per kg-1 x d-1 (FO) or 1.0 g soybean oil x kg-1 x d-1 (SO). Following 5 days' FO administration, the content of eicosapentaenoic acid (EPA) was increased 2.5-fold, LTB5 1.5-fold, and LTC5 sevenfold. With SO nutrition, EPA and LTB5 generation remained unaltered, whereas LTC5 doubled. The production of LTB4 and LTC4 was not affected in any of the groups. We conclude that a 5-day parenteral fish oil supplementation has an immunomodulatory effect on lipid-mediator generation in human leukocytes in postoperative trauma.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, Ruhr-University of Bochum, Germany.
authors.forename: B J
authors.initials: BJ
authors.lastname: Morlion
authors.forename: E
authors.initials: E
authors.lastname: Torwesten
authors.forename: H
authors.initials: H
authors.lastname: Lessire
authors.forename: G
authors.initials: G
authors.lastname: Sturm
authors.forename: B M
authors.initials: BM
authors.lastname: Peskar
authors.forename: P
authors.initials: P
authors.lastname: Fürst
authors.forename: C
authors.initials: C
authors.lastname: Puchstein
mesh_terms: D000328:Adult; D000368:Aged; D002462:Cell Membrane / Q000378:metabolism; D005227:Fatty Acids / Q000097:blood*; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology; D005260:Female; D005395:Fish Oils / Q000494:pharmacology*; D006801:Humans; D007263:Infusions, Parenteral; D007962:Leukocytes / Q000378:metabolism*; D015289:Leukotrienes / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D013024:Soybean Oil / Q000494:pharmacology; D013312:Stress, Physiological / Q000097:blood* / Q000209:etiology
chemical_list: D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D015289:Leukotrienes; D013024:Soybean Oil