title: Perfusion imaging of the human brain at 1.5 T using a single-shot EPI spin tagging approach.
abstract: Single-shot echo planar imaging (EPI) techniques have been applied, in conjunction with arterial spin tagging approaches, to obtain images of cerebral blood flow in a single axial slice in the human brain. Serial studies demonstrate that cerebral blood flow images acquired in 8 min are reproducible, with a statistical precision of approximately +/-10 cc/100 g/min. The average value of cerebral blood flow in the slice is 51 +/- 11 cc/100 g/min for six normal subjects. The cerebral blood flow images contain two types of artifact, probably due to arterial and venous blood volume contributions, which must be overcome before the arterial spin tagging approach can be used for routine clinical studies.
authors.affiliation: Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, MD 20892-1060, USA.
authors.forename: F Q
authors.initials: FQ
authors.lastname: Ye
authors.forename: J J
authors.initials: JJ
authors.lastname: Pekar
authors.forename: P
authors.initials: P
authors.lastname: Jezzard
authors.forename: J
authors.initials: J
authors.lastname: Duyn
authors.forename: J A
authors.initials: JA
authors.lastname: Frank
authors.forename: A C
authors.initials: AC
authors.lastname: McLaughlin
mesh_terms: D016477:Artifacts; D001921:Brain / Q000033:anatomy & histology*; D002560:Cerebrovascular Circulation; D017352:Echo-Planar Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D015203:Reproducibility of Results