title: Comparison of Tc-99m MIBI and TI-201/Tc-99m pertechnetate for diagnosis of primary hyperparathyroidism.
abstract: The purpose of this study was to directly compare the efficacy of Tc-99m MIBI with TI-201/Tc-99m pertechnetate scintigraphy for localizing parathyroid adenomas in patients with primary hyperparathyroidism. Of 21 patients suspected of having primary hyperparathyroidism who had undergone both studies, 14 had subsequent surgery and pathologic correlation. Based on the surgical and pathologic results, Tc-99m MIBI yielded 13 true-positive and 1 false-negative result. Thallium-201/ Tc-99m pertechnetate imaging yielded eight true-positive, four false-negative, and two nondiagnostic studies because of lack of Tc-99m pertechnetate uptake from thyroid hormone suppression. In conclusion, Tc-99m MIBI scintigraphy is an accurate method for localizing parathyroid adenomas in patients with primary hyperparathyroidism and the results suggest that it is superior to using TI-201/Tc-99m pertechnetate.
authors.affiliation: Department of Radiology, Georgetown University Hospital, Washington, District of Columbia 20007, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Rauth
authors.forename: R B
authors.initials: RB
authors.lastname: Sessions
authors.forename: S C
authors.initials: SC
authors.lastname: Shupe
authors.forename: H A
authors.initials: HA
authors.lastname: Ziessman
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000601:surgery; D007089:Image Enhancement; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010282:Parathyroid Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D012680:Sensitivity and Specificity; D016037:Single-Blind Method; D013670:Sodium Pertechnetate Tc 99m / Q000008:administration & dosage; D017256:Technetium Tc 99m Sestamibi / Q000008:administration & dosage; D013794:Thallium Radioisotopes / Q000008:administration & dosage; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000187:drug effects; D013963:Thyroid Hormones / Q000627:therapeutic use
chemical_list: D019275:Radiopharmaceuticals; D013794:Thallium Radioisotopes; D013963:Thyroid Hormones; D017256:Technetium Tc 99m Sestamibi; D013670:Sodium Pertechnetate Tc 99m