title: Fox-Fordyce disease in two prepubertal girls: histopathologic demonstration of eccrine sweat gland involvement.
abstract: This report presents two prepubertal girls with Fox-Fordyce disease. The pruritic papules extensively affected the areas where apocrine glands are distributed (axillae, periareolar and intermammary zones, pubes, infraumbilical midline), and also extended to the neck and face near the external angle of the eyes in one child. Analyses of several biopsy specimens showed that the main lesion was a spongiotic vesicle containing inflammatory cells and keratinocytes affecting the hair infundibula and acrosyringia, together, with hyperkeratosis of both adnexa. The cause of the disease remains elusive, but the microscopic findings may explain the good results obtained with keratolytic agents.
authors.affiliation: Department of Dermatology, Hospital de Niños, Superiora Sor María Ludovica, La Plata, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Ranalletta
authors.forename: A
authors.initials: A
authors.lastname: Rositto
authors.forename: R
authors.initials: R
authors.lastname: Drut
mesh_terms: D000005:Abdomen; D001050:Apocrine Glands / Q000473:pathology; D001365:Axilla / Q000473:pathology; D001940:Breast / Q000473:pathology; D002648:Child; D004439:Eccrine Glands / Q000473:pathology*; D005148:Facial Dermatoses / Q000473:pathology; D005260:Female; D005588:Fox-Fordyce Disease / Q000473:pathology*; D006197:Hair / Q000473:pathology; D006801:Humans; D015603:Keratinocytes / Q000473:pathology; D007641:Keratolytic Agents / Q000627:therapeutic use; D007642:Keratosis / Q000473:pathology; D009333:Neck / Q000473:pathology; D009558:Nipples / Q000473:pathology; D011537:Pruritus / Q000473:pathology; D011627:Puberty; D014472:Umbilicus / Q000473:pathology
chemical_list: D007641:Keratolytic Agents