title: Infection of a total knee arthroplasty by Candida parapsilosis. A case report of successful treatment by joint reimplantation with a literature review.
abstract: This article describes a case of total knee infection by Candida parapsilosis treated by joint reimplantation. Surgical treatment consisted of resection arthroplasty with wound stablization by external fixation. Antibiotic treatment consisted of 6 weeks of intravenous amphotericin B and 7 weeks of oral 5-fluorocytosine begun at the time of resection arthroplasty. Cultures at reimplantation were negative. Reimplanted components were all cemented with perioperative cefazolin antibiotic. No further antifungal treatment was necessary.
authors.affiliation: Great Falls Clinic, Department of Orthopaedic Surgery, Montana 59403, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Hennessy
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D002177:Candidiasis / Q000209:etiology / Q000628:therapy*; D003131:Combined Modality Therapy; D016267:External Fixators; D005260:Female; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D007720:Knee Prosthesis / Q000009:adverse effects*; D008875:Middle Aged; D011474:Prosthesis Design; D016459:Prosthesis-Related Infections / Q000382:microbiology* / Q000628:therapy*; D012086:Reoperation
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D005437:Flucytosine