title: Inhibition of duck hepatitis B virus replication by 2',3'-dideoxy-3'-fluoroguanosine in vitro and in vivo.
abstract: The antiviral activity of 2',3'-dideoxy-3'-fluoroguanosine (FdG) or its triphosphate was evaluated in the duck hepatitis B virus (DHBV) system in vitro and in vivo. In primary DHBV-infected hepatocytes FdG results in a dose-dependent inhibition of viral replication with a nearly complete inhibition at a concentration of 1 microM. Also in vivo, FdG treatment of DHBV-infected ducklings reduces DHBV DNA replication by more than 90%. These data demonstrate that FdG is a strong inhibitor of DHBV replication in vitro and in vivo.
authors.affiliation: Department of Medicine, University of Freiburg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Hafkemeyer
authors.forename: A
authors.initials: A
authors.lastname: Keppler-Hafkemeyer
authors.forename: M A
authors.initials: MA
authors.lastname: al Haya
authors.forename: M
authors.initials: M
authors.lastname: von Janta-Lipinski
authors.forename: E
authors.initials: E
authors.lastname: Matthes
authors.forename: C
authors.initials: C
authors.lastname: Lehmann
authors.forename: W B
authors.initials: WB
authors.lastname: Offensperger
authors.forename: S
authors.initials: S
authors.lastname: Offensperger
authors.forename: W
authors.initials: W
authors.lastname: Gerok
authors.forename: H E
authors.initials: HE
authors.lastname: Blum
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D015139:Blotting, Southern; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004279:DNA, Viral / Q000032:analysis / Q000096:biosynthesis; D015224:Dideoxynucleosides / Q000494:pharmacology* / Q000627:therapeutic use; D004372:Ducks / Q000821:virology*; D015611:Hepatitis B Virus, Duck / Q000187:drug effects*; D006524:Hepatitis, Viral, Animal / Q000188:drug therapy* / Q000821:virology; D017403:In Situ Hybridization; D008099:Liver / Q000166:cytology / Q000821:virology; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D015224:Dideoxynucleosides; C055315:3'-fluoro-2',3'-dideoxyguanosine