Successful pregnancy after bone marrow transplantation for thalassaemia.
Bone marrow transplantation from an HLA-identical sibling can cure thalassaemia. The risk of chemotherapy-induced sterility, however, represents a deterrent for many patients already at risk of gonadal insufficiency and reduced fertility because of the effects of transfusional iron overload. We report here the first patient transplanted for thalassaemia, after ablative therapy with busulfan and cyclophosphamide, who, despite late pubertal maturation, became pregnant and delivered a full-term, normal infant.
Borgna-Pignatti
C
C
Department of Pediatrics, University of Verona, Italy.
Marradi
P
P
Rugolotto
S
S
Marcolongo
A
A
D000328:Adult; D016026:Bone Marrow Transplantation; D002066:Busulfan / Q000009:adverse effects; D015913:Chelation Therapy; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000009:adverse effects; D005260:Female; D006065:Gonadotropins, Pituitary / Q000378:metabolism; D006486:Hemosiderosis / Q000150:complications; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007231:Infant, Newborn; D007501:Iron; D010903:Pituitary Gland, Anterior / Q000378:metabolism; D011247:Pregnancy; D011628:Puberty, Delayed / Q000209:etiology; D065227:Transfusion Reaction; D017086:beta-Thalassemia / Q000150:complications / Q000628:therapy*
D006065:Gonadotropins, Pituitary; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D007501:Iron; D002066:Busulfan