Synthesis of deuterated 7-(5'-deoxy-5'-methylthio-beta-D-ribofuranosyl)adenine-d3.
Synthesis of 7-(5'-deoxy-5'-methyl-thio-beta-D-ribofuranosyl)-adenine(7-MTA) has been developed from imidazole through 7-beta -D-ribofuranosyladenine. Deuterated 7-MTA-d3 was also synthesized by this synthetic procedure using deuterium labelled dimethyl disulfide-d6. The deuterium content of 7-MTA-d3 was 98.28%. The spectral and chemical properties of 7-MTA were defined.
Sugiyama
T
T
Department of Agricultural Chemistry, Meiji University, Kanagawa, Japan.
Yamashita
M
M
D003839:Deoxyadenosines / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D003903:Deuterium; D004121:Dimethyl Sulfoxide; D008722:Methods; D015394:Molecular Structure; D013056:Spectrophotometry, Ultraviolet; D013872:Thionucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification
D003839:Deoxyadenosines; D013872:Thionucleosides; C008500:5'-methylthioadenosine; D003903:Deuterium; D004121:Dimethyl Sulfoxide