[The role of calcitonin gene-related peptide fragments in regulating the microcirculation in rats].
Fragments of the calcitonin gene-related neuropeptide's molecule with the amino acid sequence 1-9, 10-20, 15-24, 20-29 and 30-37, were studied. The fragment 20-29 revealed the greatest biological activity: it induced a dose-dependent drop of arterial pressure in i.v. administration, enlarges arterial and venous microvessels when locally applied.
Akopian
V A
VA
Balashov
N V
NV
Burov
S V
SV
Vlasov
G P
GP
Korol'kov
V I
VI
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D008208:Lymphatic System / Q000187:drug effects / Q000502:physiology; D008297:Male; D008643:Mesentery / Q000098:blood supply* / Q000187:drug effects; D008833:Microcirculation / Q000187:drug effects / Q000502:physiology; D010446:Peptide Fragments / Q000494:pharmacology / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
D010446:Peptide Fragments; D015740:Calcitonin Gene-Related Peptide