title: [Haemostatic defects in venous thromboembolic disease].
abstract: The aim of this study was to assess the frequency of haemostatic defects in 78 patients with the history of venous thromboembolic disease. In all patients antithrombin III activity and in 50 of them protein C, in 53-protein S, in 49 activated protein C (APC) resistance, plasminogen, alfa-2-antiplasmin were measured. We found 35 patients with haemostatic defect: 3 patients with decreased protein C activity and one case with decrease of protein C both activity and antigen level; 15 patients with decreaced antithrombin III activity; 7 patients with decreased free protein S antigen level; 5 patients with APC resistance. In 4 patients we found more than one defect; 2 patients had decreased concentration of free protein S and APC resistance, one patient had decreased activity of both antithrombin III and protein C, one patient had decreased antithrombin III activity and free protein S antigen level. Plasminogen and alfa-2-antiplasmin levels were within the normal range. Family studies indicated hereditary thrombophilia in 6 families. Screening for thrombophilia is very important for the optimal prophylaxis and treatment of venous thromboembolic disease.
authors.affiliation: Kliniki Hematologii Instytutu Chorób Wewnetrznych Akademii Medycznej.
authors.forename: A
authors.initials: A
authors.lastname: Grzywacz
authors.forename: P
authors.initials: P
authors.lastname: Psuja
authors.forename: Z
authors.initials: Z
authors.lastname: Turowiecka
authors.forename: K
authors.initials: K
authors.lastname: Lewandowski
authors.forename: M
authors.initials: M
authors.lastname: Zozulińska
authors.forename: K
authors.initials: K
authors.lastname: Zawilska
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000502:physiology; D005260:Female; D005820:Genetic Testing; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000502:physiology; D017293:Protein S / Q000502:physiology; D013923:Thromboembolism / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy
chemical_list: D011486:Protein C; D017293:Protein S; D000990:Antithrombin III