Continuous urine oxygen tension monitoring in patients undergoing cardiac surgery.
OBJECTIVE
To evaluate the effect of cardiopulmonary bypass (CPB) on urine oxygen tension (PuO2) and to determine whether perioperative PuO2 can predict postoperative renal dysfunction in patients undergoing cardiac surgery.


METHODS
Prospective clinical study.


METHODS
A university research laboratory, a university-affiliated hospital.


METHODS
Ninety-eight consecutive adult patients undergoing coronary artery bypass surgery or valvular surgery.


METHODS
PuO2 was continuously measured by inserting a polarographic electrode into the urinary tube connected to a Foley catheter.


RESULTS
PuO2 was constant before CPB and then progressively decreased after the start of CPB. It partially recovered at weaning from CPB but did not completely return to its original level until the end of surgery. Postoperative serum creatinine concentrations were significantly higher in patients whose PuO2 decreased after CPB, as compared with those whose PuO2 was constant or increased. The amplitude and the rate of recovery in PuO2 after CPB were significantly associated with peak values of postoperative serum creatinine concentrations.


CONCLUSIONS
These results suggest the possibility of PuO2 detecting an early stage of renal dysfunction in cardiac surgery, although further studies will be required to substantiate it.
Kainuma
M
M
Department of Anesthesiology, Fujita Health University School of Medicine, Aichi, Japan.
Yamada
M
M
Miyake
T
T
D058186:Acute Kidney Injury / Q000175:diagnosis*; D000328:Adult; D000368:Aged; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000652:urine*; D011446:Prospective Studies
D010100:Oxygen