Prolonged ciprofloxacin administration does not accelerate neutrophil recovery after autologous bone marrow transplantation.
OBJECTIVE
To determine whether prolonged ciprofloxacin administration following autologous bone marrow transplantation (ABMT) accelerates neutrophil recovery.


METHODS
Retrospective analysis of 40 consecutive patients undergoing ABMT.


METHODS
Tertiary care bone marrow transplant program.


METHODS
Two sequential arms of 20 consecutive patients with Hodgkin's disease or non-Hodgkin's lymphoma undergoing ABMT.


METHODS
The first arm received ciprofloxacin from the day of transplantation until initiation of broad-spectrum antibiotic therapy (median 5 days) while the second arm continued ciprofloxacin until recovery of the neutrophil count (median 15 days).


RESULTS
Neutrophil recovery was similar in the two groups (16 vs 14 days; p = 0.41). There were no differences in platelet recovery, bacteremia, or treatment-related mortality.


CONCLUSIONS
Prolonged ciprofloxacin administration does not significantly accelerate neutrophil recovery following ABMT.
Hsu
J
J
University of Toronto Autologous Blood and Marrow Transplant Program, Toronto Hospital, Ontario, Canada.
Prince
H M
HM
Imrie
K R
KR
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D016026:Bone Marrow Transplantation; D002939:Ciprofloxacin / Q000008:administration & dosage*; D005260:Female; D006689:Hodgkin Disease / Q000628:therapy; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000188:drug therapy*; D009504:Neutrophils / Q000187:drug effects*; D012189:Retrospective Studies; D014182:Transplantation, Autologous
D000890:Anti-Infective Agents; D002939:Ciprofloxacin