title: Lack of activational influence of ovarian hormones on the size of the female rat's corpus callosum.
abstract: The sex difference in the midsagittal area of the adult rat corpus callosum (CC) has been shown to be mediated, in part, by gonadal steroids in early development, with the sensitive period of hormone action in the female extending at least up to postnatal day 25. Given this prolonged sensitivity, the current study attempted to delineate organizational vs. activational influences of gonadal hormones on the female rat CC. In Experiment 1, callosal size was examined across the estrous cycle at 52 and 90 days of age. In Experiment 2, females were ovariectomized at 78 days and CC parameters assessed at 110 days. Last, in Experiment 3, females were ovariectomized at 78 days and sacrificed at 110 days; in addition, sham females were sacrificed during proestrus or estrus. Neither stage of estrous cycle nor adult ovariectomy affected midsagittal CC size. These results provide evidence for organizational effects of ovarian steroids on the female callosum, with the sensitive period of hormone action ending sometime between days 25 and 78.
authors.affiliation: Biobehavioral Sciences Graduate Degree Program, University of Connecticut, Storrs 06269, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Mack
authors.forename: R H
authors.initials: RH
authors.lastname: Fitch
authors.forename: L A
authors.initials: LA
authors.lastname: Hyde
authors.forename: A J
authors.initials: AJ
authors.lastname: Seaman
authors.forename: H A
authors.initials: HA
authors.lastname: Bimonte
authors.forename: W
authors.initials: W
authors.lastname: Wei
authors.forename: V H
authors.initials: VH
authors.lastname: Denenberg
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000254:growth & development; D003337:Corpus Callosum / Q000187:drug effects / Q000254:growth & development*; D004967:Estrogens / Q000494:pharmacology* / Q000502:physiology*; D004971:Estrus / Q000187:drug effects; D005260:Female; D009929:Organ Size / Q000187:drug effects; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D014599:Uterus / Q000187:drug effects / Q000254:growth & development
chemical_list: D004967:Estrogens