Neuronal lesions and behavioral modifications in rat following cerebral ischemia and reperfusion.
Neurons of the mammalian CNS differ in their vulnerability to various disease processes and other insults, particularly in their response to total anoxia/ischemia. In this study we have tested the histological and behavioral modifications induced by experimental conditions of partial cerebral ischemia in the rats. The specific morphological and histological alterations, observed in our experimental conditions of reversible partial cerebral ischemia, confirm the selective vulnerability of certain neuronal populations to ischemic injury and are also evidenced by behavioral modifications which may mirror the functional impairment observed in humans after a transitory ischemic attack.
Martinez
G
G
Institute of Human Anatomy, University of Catania, Italy.
Carnazza
M L
ML
Giacomo
C D
CD
Sorrenti
V
V
Castana
R
R
Pennisi
G
G
Perez-Polo
J R
JR
Vanella
A
A
D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology*; D005069:Evaluation Studies as Topic; D007858:Learning / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009474:Neurons / Q000502:physiology* / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000503:physiopathology*