title: Production of [18F]F2 using the 16O(3He,p)18F reaction.
abstract: For the first time, the 16O(3He,p)18F reaction has been used for the production of 18F electrophilic reagents. The predominant reactive chemical specie recovered in the single-step postirradiation gases was [18F]F2. Decay curve and Ge(Li) analyses established the main radionuclidic impurities in this nuclear reaction as 11C and 15O. Recovery of the 18F activity was exceptionally high, approaching 90% using an electroformed nickel target body. Consistent 18F recoveries for this nuclear reaction (approximately 70%) were realized with a novel aluminum target body. The utility of the [18F]F2 recovered from this oxygen gas target system in radiopharmaceutical preparations is demonstrated by the successful synthesis of 6-[18F]fluoro-L-dopa (11.0 mCi at EOB) via a fluorodemercuration method.
authors.affiliation: Department of Molecular and Medical Pharmacology, UCLA School of Medicine, USA.
authors.forename: A
authors.initials: A
authors.lastname: Bishop
authors.forename: N
authors.initials: N
authors.lastname: Satyamurthy
authors.forename: G
authors.initials: G
authors.lastname: Bida
authors.forename: M
authors.initials: M
authors.lastname: Phelps
authors.forename: J R
authors.initials: JR
authors.lastname: Barrio
mesh_terms: D005462:Fluorine Radioisotopes / Q000737:chemistry* / Q000302:isolation & purification; D005740:Gases; D006371:Helium / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods; D010100:Oxygen / Q000737:chemistry*; D011854:Radiochemistry / Q000379:methods*
chemical_list: D005462:Fluorine Radioisotopes; D005740:Gases; D006371:Helium; D010100:Oxygen