title: Neuroendocrine differentiation in non-neuroendocrine thyroid carcinoma.
abstract: Specimens from 40 cases of thyroid carcinomas, including 35 papillary, 2 follicular, 2 undifferentiated, and 1 Hurtle cell carcinoma were analyzed for neuroendocrine differentiation with immunohistochemical tests for synapthophysin, neuron-specific enolase (NSE), chromogranin, and calcitonin; all cases were stained for thyroglobulin. Histologically, none of the cases resembled a medullary carcinoma. Twenty-five percent (10 cases) were immunoreactive for one, 30% (12 cases) for two, and 15% (6 cases) for three markers. Three of the cases that were positive for all 3 markers (7.5% of all total) had diffuse strong immunoreactivity. These results demonstrated neuroendocrine differentiation may occur in non-neuroendocrine thyroid tumors and may support the postulation that endodermally derived ultimobronchial stem cells might give rise to C cells as well as follicular cells.
authors.affiliation: Department of Pathology, Faculty of medicine, Dokuz Eylül University, Izmir, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Kargi
authors.lastname: Yörükoglu
authors.forename: S
authors.initials: S
authors.lastname: Aktaş
authors.lastname: Cakalagaoglu
authors.forename: M
authors.initials: M
authors.lastname: Ermete
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000473:pathology; D002116:Calcitonin / Q000032:analysis; D002277:Carcinoma / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000473:pathology; D002454:Cell Differentiation; D002864:Chromogranins / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D009490:Neurosecretory Systems / Q000473:pathology*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D016708:Synaptophysin / Q000032:analysis; D013954:Thyroglobulin / Q000032:analysis; D013964:Thyroid Neoplasms / Q000473:pathology*
chemical_list: D002864:Chromogranins; D016708:Synaptophysin; D002116:Calcitonin; D013954:Thyroglobulin; D010751:Phosphopyruvate Hydratase