title: Role of serotonin3 receptors in prolactin release induced by electroconvulsive therapy: a study with ondansetron.
abstract: The effect of pretreatment with odansetron on prolactin (PRL) release induced by electroconvulsive therapy (ECT) was examined in 16 depressive patients in a double-blind, placebo-controlled crossover study. Ten patients were pretreated with 4 mg and the other six with 8 mg of ondansetron. The order of administration of study medication (ondansetron and placebo) was counterbalanced. The failure of ondansetron to attenuate ECT-induced PRL release suggested that serotonin3 receptors are not involved in mediating this response.
authors.affiliation: Department of Psychiatry, University of British Columbia, Vancouver, Canada.
authors.forename: L N
authors.initials: LN
authors.lastname: Yatham
authors.forename: A P
authors.initials: AP
authors.lastname: Zis
authors.forename: R W
authors.initials: RW
authors.lastname: Lam
authors.forename: M
authors.initials: M
authors.lastname: Srisurapanont
authors.forename: K
authors.initials: K
authors.lastname: McGarvey
authors.forename: O
authors.initials: O
authors.lastname: Agbayewa
mesh_terms: D000328:Adult; D018592:Cross-Over Studies; D003866:Depressive Disorder / Q000188:drug therapy* / Q000628:therapy*; D004311:Double-Blind Method; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017294:Ondansetron / Q000494:pharmacology* / Q000627:therapeutic use*; D010919:Placebos; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000187:drug effects*; D012701:Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D010919:Placebos; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D012701:Serotonin; D017294:Ondansetron; D011388:Prolactin