Fungal glycoproteins and their biosynthetic pathway as potential targets for antifungal agents.
The yeast cell wall as a good antifungal target is discussed in general. More specifically the reaction, catalyzed by Dol-P-Man: protein O-D-mannosyltransferase is proposed as a new potential target. Six genes responsible for this endoplasmic reticulum-localized reaction have been cloned and characterized so far. Triple disruptions of these genes are either lethal or the corresponding cells have to be osmotically stabilized to survive. No inhibitors of this reaction are as yet known.
Tanner
W
W
Lehrstuhl für Zellbiologie und Pflanzenphysiologie, University of Regensburg, Germany.
Gentzsch
M
M
Immervoll
T
T
Scheinost
A
A
Strahl-Bolsinger
S
S
D000935:Antifungal Agents / Q000494:pharmacology*; D002473:Cell Wall / Q000378:metabolism; D006023:Glycoproteins / Q000096:biosynthesis* / Q000378:metabolism; D006031:Glycosylation; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000378:metabolism*
D000935:Antifungal Agents; D006023:Glycoproteins