title: Predicting cognitive impairment in epilepsy: findings from the Bozeman epilepsy consortium.
abstract: We examined the contribution of age of seizure onset, seizure duration, seizure laterality, seizure location, gender, handedness, and cerebral speech representation to cognitive attainment in 1,141 patients with medically refractory seizures. The combined influence of the predictor variables was modest. Age of seizure onset was the best single indicator of Full Scale IQ (partial r = .23) and General Memory (partial r = .20). Laterality and location of dysfunction, and cerebral speech dominance were also relevant and independent indicators of aspects of cognition. Except for age of onset of seizures (early onset was associated with poorer cognitive attainment), however, the magnitude of the effects was limited.
authors.affiliation: Department of Psychology, University of Victoria, British, Columbia, Canada.
authors.forename: E
authors.initials: E
authors.lastname: Strauss
authors.forename: D
authors.initials: D
authors.lastname: Loring
authors.forename: G
authors.initials: G
authors.lastname: Chelune
authors.forename: M
authors.initials: M
authors.lastname: Hunter
authors.forename: B
authors.initials: B
authors.lastname: Hermann
authors.forename: K
authors.initials: K
authors.lastname: Perrine
authors.forename: M
authors.initials: M
authors.lastname: Westerveld
authors.forename: M
authors.initials: M
authors.lastname: Trenerry
authors.forename: W
authors.initials: W
authors.lastname: Barr
mesh_terms: D000328:Adult; D017668:Age of Onset; D003072:Cognition Disorders / Q000523:psychology*; D004827:Epilepsy / Q000523:psychology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008568:Memory; D011569:Psychiatric Status Rating Scales