title: Evaluation of certain ureas and nitrosoureas of 2,3-dihydro-1,4-benzothiazines against Sarcoma-180 solid tumors in vivo.
abstract: Different derivatives of nitrosoureas were synthesized by a long sequence of reactions and were evaluated for their anticancer activities against female Swiss albino mice, 6-8 weeks old, weighing 18-24 g and bearing Sarcoma-180 (S-180) ascitic tumor. Experimental protocols include injecting a total of 2 x 10(5) S-180 viable ascitic cells s.c. on day 0 in the left flank of mice to obtain solid tumors, followed by the treatment of urea/nitrosourea derivatives on days 1, 5 and 9 at different dose levels. Of the 32 compounds tested, eight were found highly active against solid tumors with significant growth delay and tumor weight inhibition ratio. 5-Fluorouracil was injected s.c. as referent compound to positive control animals.
authors.affiliation: Department of Zoology, University of Rajasthan, Jaipur, India.
authors.forename: M K
authors.initials: MK
authors.lastname: Nyati
authors.forename: C M
authors.initials: CM
authors.lastname: Rajoria
authors.forename: R R
authors.initials: RR
authors.lastname: Gupta
authors.forename: P K
authors.initials: PK
authors.lastname: Dev
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D051379:Mice; D012510:Sarcoma 180 / Q000188:drug therapy*; D013843:Thiazines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use*; D014508:Urea / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D013843:Thiazines; C097624:2,3-dihydro-1,4-benzothiazine; D014508:Urea