A specific beta 3-adrenoceptor agonist induces increased pancreatic islet blood flow and insulin secretion in rats.
In order to study the role of beta 3-adrenoceptor stimulation on insulin secretion in rats, plasma insulin level and islet blood flow were measured during treatment with CL 316243 which is chemically named disodium (R,R)-5-[2-[[2,3-(3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]-1, 3-benzodioxole-2,2-dicarboxylate, a specific beta 3-adrenoceptor agonist. CL 316243 induced a marked increase in both islet blood flow and plasma insulin concentration without changes in whole pancreatic blood flow. This increase was totally prevented when the rats were pretreated with bupranolol, a beta 1, beta 2, beta 3-adrenoceptor antagonist, but not with nadolol, a beta 1, beta 2-adrenoceptor antagonist. We conclude that beta 3-adrenoceptor stimulation provokes a marked vasodilatation of microvessels in the islets of Langerhans, which in turn could contribute to the increase in insulin secretion.
Atef
N
N
Laboratory of Physiopathology of Nutrition, CNRS URA 307, University Paris VII, France.
Lafontan
M
M
Doublé
A
A
Hélary
C
C
Ktorza
A
A
Pénicaud
L
L
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D002046:Bupranolol / Q000494:pharmacology; D004149:Dioxoles / Q000494:pharmacology*; D005260:Female; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D009248:Nadolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D022702:Receptors, Adrenergic, beta-3; D012039:Regional Blood Flow / Q000187:drug effects
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D004149:Dioxoles; D007328:Insulin; D011943:Receptors, Adrenergic, beta; D022702:Receptors, Adrenergic, beta-3; C076126:disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate; D009248:Nadolol; D002046:Bupranolol