title: Gene therapy of diabetes mellitus--aims, methods and future prospects.
abstract: Progress in pancreatic islet research and molecular biology techniques has opened the perspective for gene therapy of diabetes mellitus. This review will focus on the prerequisites for the generation of genetically engineered insulin-producing cells and current methods of gene transfer. A short account of the genetically modified insulin-secreting cell lines generated so far is also given. Although still experimental each of these new insulin-secreting cell lines is a step forward on the way to gene therapy of human diabetes.
authors.affiliation: Institute of Clinical Biochemistry, Hannover Medical School, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Tiedge
authors.forename: S
authors.initials: S
authors.lastname: Lenzen
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000235:genetics / Q000628:therapy*; D015870:Gene Expression / Q000502:physiology; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods / Q000639:trends; D006801:Humans; D007328:Insulin / Q000235:genetics / Q000378:metabolism*; D000078790:Insulin Secretion
chemical_list: D007328:Insulin