[Lipid peroxidation in an experimental study of an erosion-ulcer lesion of the stomach as affected by the new high-protein products and ethonium].
New high-protein vitamin product "Biostim" and bisquaternary ammonium compound etonium have been studied for their effect on the content of endogenic lipids (isolated binary bonds, diene conjugates, ketodienes and conjugated trienes) and reduced glutathione in the stomach and liver tissues under experimental duodenal ulcer with results presented. Maximal effect of "Biostim" on the intensity of the processes of free-radical oxidation in these tissue falls on the 14th day of the experiment, that of etonium on the 10th day, their simultaneous use--on the 6th day of the treatment. It is supposed that the combination of the above drugs takes most pronounced antioxidant effect owing to the fact that etonium activates the operation of glutathione cycle, promotes blocking of formation of free radicals and interacts with them. Under these conditions biosynthetic processes in the cell membranes induced by "Biostim" are more intensive and this, in its turn, promotes free-radical inhibition of lipids and biopolymers.
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D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D001426:Bacterial Proteins / Q000627:therapeutic use*; D005609:Free Radicals; D005753:Gastric Mucosa / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010437:Peptic Ulcer / Q000188:drug therapy* / Q000378:metabolism; D000644:Quaternary Ammonium Compounds / Q000627:therapeutic use*; D051381:Rats; D013270:Stomach / Q000187:drug effects
D000897:Anti-Ulcer Agents; D000975:Antioxidants; D001426:Bacterial Proteins; D005609:Free Radicals; D000644:Quaternary Ammonium Compounds; C004921:Ethonium; C037567:glycoprotein, Klebsiella pneumoniae