Acellular human dermal matrix as a small vessel substitute.
In both vascular and microvascular surgery, there is a need for a non-thrombogenic, small-caliber, arterial substitute. Clinically, most vessel substitutes with diameters under 4 mm have low patency rates. An arterial conduit made from a biocompatible human acellular dermis may be useful as a small vessel conduit. The purpose of this study was to evaluate and compare the patency rates of a vascular conduit made from rolled human acellular dermal (ACD) matrix and a similar-sized polytetrafluoroethylene (PTFE) tube, using the rat femoral artery interposition model. Twenty-eight days after implantation, 9 or 10 (90 percent) ACD grafts and 5 of 8 (62.5 percent) PTFE grafts were patent. False aneurysms formed in 6 ACD conduits along the longitudinal suture line. The three patent non-aneurysmal ACD conduits developed an endothelial luminal lining. While further studies are needed, acellular dermis appears to be a promising material for use as a vessel substitute.
Inoue
Y
Y
Department of Plastic and Reconstructive Surgery, Kurume University School of Medicine, Japan.
Anthony
J P
JP
Lleon
P
P
Young
D M
DM
D017541:Aneurysm, False / Q000209:etiology; D000818:Animals; D001807:Blood Vessel Prosthesis; D005263:Femoral Artery / Q000601:surgery*; D006801:Humans; D008297:Male; D011138:Polytetrafluoroethylene; D011183:Postoperative Complications; D051381:Rats; D017207:Rats, Sprague-Dawley; D016038:Skin Transplantation; D014183:Transplantation, Heterologous; D014654:Vascular Patency
D011138:Polytetrafluoroethylene