Dopamine transporter gene polymorphism and psychiatric symptoms seen in schizophrenic patients at their first episode.
To investigate the possible role of the dopamine transporter (DAT) gene in determining the phenotype in human subjects, allele frequencies for the 40-bp variable number of tandem repeats (VNTR) polymorphism at this site were compared between 117 Japanese normal controls and 118 schizophrenic patients, including six subgroups: early-onset, those with a family history, and those suffering from one of the following psychiatric symptoms at their first episode: delusion and hallucination; disorganization; bizarre behavior; and negative symptoms. No significant differences were observed between the group as a whole or any subgroup of schizophrenic patients and controls. The results indicate that VNTR polymorphism in the DAT gene is unlikely to be a major contributor to any of the psychiatric parameters examined in the present population of schizophrenic subjects.
Inada
T
T
National Institute of Mental Health, National Center of Neurology and Psychiatry, Chiba, Japan.
Sugita
T
T
Dobashi
I
I
Inagaki
A
A
Kitao
Y
Y
Matsuda
G
G
Kato
S
S
Takano
T
T
Yagi
G
G
Asai
M
M
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D002352:Carrier Proteins / Q000235:genetics*; D004247:DNA / Q000097:blood; D003702:Delusions; D050483:Dopamine Plasma Membrane Transport Proteins; D005260:Female; D005787:Gene Frequency; D006212:Hallucinations; D006801:Humans; D007564:Japan; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D008875:Middle Aged; D018598:Minisatellite Repeats; D009419:Nerve Tissue Proteins; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012016:Reference Values; D012559:Schizophrenia / Q000235:genetics*; D012563:Schizophrenia, Paranoid / Q000235:genetics; D012565:Schizophrenic Psychology
D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493214:SLC6A3 protein, human; D004247:DNA