title: Contribution to heart rate variability by mechanoelectric feedback. Stretch of the sinoatrial node reduces heart rate variability.
abstract: BACKGROUND
  Heart rate variability is an important prognostic indicator for sudden death. An increased risk of sudden death and arrhythmia is associated with reduced heart rate variability in heart failure. In heart failure, there is also dilatation of the atria, which raises the prospect that there could be some physiological basis to possibly link heart rate variability with atrial dilatation. We therefore investigated whether sustained atrial stretch could modulate heart rate variability directly.
  
  
  RESULTS
  Pigs were anesthetized and their hearts exposed. A specially built device stretched the sinoatrial node before and after vagal section and then after administration of propranolol. Stretch of the sinoatrial node decreases heart rate variability in the following ways: The standard deviation of the beat-to-beat interval decreases (4.2 to 2.6 ms; P = .004), and the high-frequency components are reduced (control, 6.5 +/- 2.2 ms2, during stretch, 1.4 +/- 0.3 ms2, P = .003). After section of both vagi, the high-frequency components are reduced by stretch of the sinoatrial node (2.8 +/- 0.9 ms2 for control versus 1.2 +/- 0.3 ms2 during stretch; P = .05). Similarly, after both vagal section and beta-blockade, stretch of the sinoatrial node reduces the high-frequency components (10.6 +/- 3.5 ms2 for control verses 3.0 +/- 1.5 ms2 during stretch; P = .01).
  
  
  CONCLUSIONS
  We conclude that stretch of the sinoatrial node reduces high-frequency heart rate variability. This may account in part for the reduced heart rate variability seen in clinical conditions in which the right atrium is dilated, such as congestive cardiac failure.
authors.affiliation: British Heart Foundation Cardiac Arrhythmia Research Group, Department of Physiology, Charing Cross and Westminster Medical School, London, England.
authors.forename: S M
authors.initials: SM
authors.lastname: Horner
authors.forename: C F
authors.initials: CF
authors.lastname: Murphy
authors.forename: B
authors.initials: B
authors.lastname: Coen
authors.forename: D J
authors.initials: DJ
authors.lastname: Dick
authors.forename: F G
authors.initials: FG
authors.lastname: Harrison
authors.forename: Z
authors.initials: Z
authors.lastname: Vespalcova
authors.forename: M J
authors.initials: MJ
authors.lastname: Lab
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D016280:Atrial Function, Right; D001340:Autonomic Nerve Block; D001696:Biomechanical Phenomena; D003714:Denervation; D004562:Electrocardiography; D004594:Electrophysiology; D005246:Feedback; D005260:Female; D006339:Heart Rate; D008297:Male; D010812:Physical Stimulation; D011433:Propranolol / Q000494:pharmacology; D012849:Sinoatrial Node / Q000502:physiology*; D013552:Swine; D014630:Vagus Nerve / Q000502:physiology
chemical_list: D000319:Adrenergic beta-Antagonists; D011433:Propranolol