Amelanotic Spitzoid melanoma in the burn scar of a child.
We report a 3-year-old girl with a rapidly growing, amelanotic, nodular melanoma developing within a burn scar over the dorsal aspect of the left foot. Histologically, the lesion was spindle cell and exhibited lack of maturation, cellular atypia, and scattered mitotic figures. Twenty five percent of the tumor cells were positive for proliferating cell nuclear antigen by immunohistochemical stain. A left inguinal lymph node was also positive for regional metastasis. The child died with disseminated metastases 13 months after the lesion was removed.
Ghorbani
Z
Z
Center for Research and Education in Skin Disease and Leprosy, Tehran, Iran.
Dowlati
Y
Y
Mehregan
A H
AH
D002056:Burns / Q000473:pathology*; D002675:Child, Preschool; D002921:Cicatrix / Q000473:pathology*; D004396:Coloring Agents; D017809:Fatal Outcome; D005260:Female; D005534:Foot Diseases / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007264:Inguinal Canal; D008207:Lymphatic Metastasis; D018328:Melanoma, Amelanotic / Q000473:pathology* / Q000556:secondary; D008938:Mitosis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D012878:Skin Neoplasms / Q000473:pathology*
D004396:Coloring Agents; D018809:Proliferating Cell Nuclear Antigen