title: Vasodilator effect of human adrenomedullin(13-52) on hypertensive rats.
abstract: Human adrenomedullin (hADM) is a newly isolated peptide with hypotensive activity in normotensive rats. The objective of this study was to investigate the effect of hADM(13-52) on hypertensive animals. hADM(13-52) induced a dose-dependent decrease in the blood pressure of spontaneously hypertensive rats and renal hypertensive rats. This result suggests that hADM is a novel antihypertensive peptide. In isolated rat aortic arteries, hADM(13-52) produced nitric oxide dependent relaxation and inhibited endothelin 1 and angiotensin II release. These in vitro effects may represent the molecular mechanisms underlying the hypotensive action of hADM in vivo.
authors.affiliation: J.K. Chang Peptide Research Laboratory, Beijing Medical University, People's Republic of China.
authors.forename: Q
authors.initials: Q
authors.lastname: Tian
authors.forename: D
authors.initials: D
authors.lastname: Zhao
authors.forename: D Y
authors.initials: DY
authors.lastname: Tan
authors.forename: Y T
authors.initials: YT
authors.lastname: Zhao
authors.forename: Q H
authors.initials: QH
authors.lastname: Li
authors.forename: J X
authors.initials: JX
authors.lastname: Qiu
authors.forename: L W
authors.initials: LW
authors.lastname: Song
authors.forename: C N
authors.initials: CN
authors.lastname: Gong
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.forename: H
authors.initials: H
authors.lastname: Lippton
mesh_terms: D053607:Adrenomedullin; D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D016232:Endothelins / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D009569:Nitric Oxide / Q000502:physiology; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D000959:Antihypertensive Agents; D016232:Endothelins; D010446:Peptide Fragments; D014665:Vasodilator Agents; C094546:adrenomedullin (13-52); D000804:Angiotensin II; D053607:Adrenomedullin; D009569:Nitric Oxide