Empirical liposomal amphotericin-B therapy in a neutropenic patient: breakthrough of disseminated Blastoschizomyces capitatus infection.
Blastoschizomyces capitatus (Trichosporon capitatum) is an uncommon fungal pathogen. Infections have mostly been seen in immunocompromised patients and use of broad spectrum antibiotics was identified as a risk factor. Treatment has been extremely difficult. A report is presented about a case of fatal B. capitatum infection with clinical septicemia and multiorgan failure during intravenous liposomal amphotericin B therapy.
Plum
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Institut für Medizinische Mikrobiologie und Hygiene, Köln, Germany.
Scheid
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C
Franzen
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C
Schütt-Gerowitt
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H
Seifert
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H
Wickramanayake
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PD
D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage*; D004337:Drug Carriers; D017809:Fatal Outcome; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications; D008081:Liposomes; D008297:Male; D009181:Mycoses / Q000188:drug therapy*; D009503:Neutropenia / Q000150:complications; D017211:Treatment Failure; D014250:Trichosporon / Q000302:isolation & purification*
D004337:Drug Carriers; D008081:Liposomes; D000666:Amphotericin B