[A study of soluble form of L-selectin in blood of patients with neuroimmunological disorders].
Members of the selection family mediate the first step of leukocyte-endothelial cell interaction in inflammatory lesion. We have examined the soluble form of L-selectin (sL-selectin) in patients with neuroimmunological disorders (48 multiple sclerosis, 2 Balo's sclerosis, 18 Guillain-Barré syndrome, 7 Miller-Fisher syndrome, 8 chronic inflammatory demyelinating polyneuropathy, and 25 human T-lymphotropic virus type-1 associated myelopathy). The levels of sL-selectin were measured by monoclonal antibody-based enzyme immunoassay on serum samples taken from patients with neuro immunological disorders. The level of sL-selectin were significantly decreased in the blood of patient with inactive stage of multiple sclerosis (MS), Guillain-Barré syndrome (GBS), and human T-lymphotropic virus type-1 associated myelopathy (HAM). The levels of sL-selectin in the sera of patients with active phase of MS tended to be high, but not significantly increased. The levels of sL-selectin, however, in the sort of patients with Balo's concentric sclerosis tended to be decreased. Thus, the findings that the serum concentrations of sL-selectin were decreased in stable phase of MS and acute phase of GBS and HAM suggest that sL-selectin may be differently involved in between patients with MS and patients with GBS or HAM.
Sakai
T
T
Department of Medicine (Neurology), Shinshu University School of Medicine.
Inoue
A
A
Koh
C S
CS
Yamazaki
M
M
Yanagisawa
N
N
D000328:Adult; D003711:Demyelinating Diseases / Q000097:blood*; D006801:Humans; D019041:L-Selectin / Q000097:blood*; D009103:Multiple Sclerosis / Q000097:blood*; D015493:Paraparesis, Tropical Spastic / Q000097:blood*; D011129:Polyradiculoneuropathy / Q000097:blood*
D019041:L-Selectin