title: Antibacterial activity of some Garcinia benzophenone derivatives against methicillin-resistant Staphylococcus aureus.
abstract: Benzophenone derivatives, garcinol (1) and isogarcinol (2) isolated from the pericarps of Garcinia purpurea (Guttiferae), and xanthochymol (3) and a mixture of isoxanthochymol (4) cycloxanthochymol (5) from the pericarps of G. subelliptica were evaluated for their antibacterial activity against methicillin-resistant Staphylococcus aureus. Among them, 3 showed the lowest minimum inhibitory concentration at 3.1-12.5 micrograms/ml. This concentration is nearly equal to that of the antibiotic, vancomycin.
authors.affiliation: Department of Pharmacognosy, Gifu Pharmaceutical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Iinuma
authors.forename: H
authors.initials: H
authors.lastname: Tosa
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Kanamaru
authors.forename: F
authors.initials: F
authors.lastname: Asai
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: K
authors.initials: K
authors.lastname: Miyauchi
authors.forename: R
authors.initials: R
authors.lastname: Shimano
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001577:Benzophenones / Q000494:pharmacology*; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects*; D013729:Terpenes / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001577:Benzophenones; D013729:Terpenes; C054597:garcinol