Some repair-deficient mutants of Dictyostelium discoideum display enhanced susceptibilities to bleomycin.
Dictyostelium discoideum, a soil eukaryote, is highly resistant to DNA-damaging agents; repair mutants are more susceptible. Susceptibility to bleomycin, produced by Streptomyces verticillus, is greater for mutants which are susceptible to other agents than for resistant strains. The high potential for DNA repair may result from the need to cope with chemicals produced by other soil microorganisms.
Deering
R A
RA
Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park 16802, USA.
Guyer
R B
RB
Stevens
L
L
Watson-Thais
T E
TE
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001761:Bleomycin / Q000494:pharmacology*; D004260:DNA Repair / Q000235:genetics*; D004269:DNA, Bacterial / Q000187:drug effects*; D004023:Dictyostelium / Q000187:drug effects* / Q000235:genetics* / Q000254:growth & development; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial; D009154:Mutation
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D001761:Bleomycin