Genetic analysis of aging in Saccharomyces cerevisiae.
The natural limits to life span are poorly understood. Yeast is a good model organism for studies of the aging process because single cells can be followed for many cell divisions and their loss of division potential follows kinetics identical to mortality rates in complex organisms. Recent experimental approaches in yeast are beginning to lead to basic models of the factors that facilitate aging.
Kennedy
B K
BK
Department of Biology, MIT, Cambridge, MA 02139, USA. bkennedy@mit.edu
Guarente
L
L
D016922:Cellular Senescence / Q000235:genetics; D005656:Fungal Proteins / Q000235:genetics; D005800:Genes, Fungal; D008957:Models, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000254:growth & development*; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; D013997:Time Factors
D005656:Fungal Proteins; C061573:SIR4 protein, S cerevisiae; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae