title: Influence of carboxylate ions containing polymers on calcification: in vitro study.
abstract: Calcification of implant or surrounding tissues represents an important complication of its function. The role of the molecular structure of a model hydrogel on the calcification is studied here in a simple in vitro, cell free system. The results show that-COO- containing polymers have an inhibitory effect on Ca2+ crystal formation. This process seems to be unspecific, because the polymers of different structure and origin have an inhibitory effect. However, its efficiency is related to a different extent of Ca2+ binding capacity of distinct polymers.
authors.affiliation: Institute of Anatomy, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
authors.forename: K
authors.initials: K
authors.lastname: Smetana
authors.forename: M
authors.initials: M
authors.lastname: Stol
authors.forename: M
authors.initials: M
authors.lastname: Novák
authors.forename: J
authors.initials: J
authors.lastname: Danes
mesh_terms: D000464:Alginates; D001672:Biocompatible Materials / Q000009:adverse effects; D002114:Calcinosis; D002118:Calcium; D002264:Carboxylic Acids; D002474:Cell-Free System; D005780:Gelatin / Q000737:chemistry*; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D006820:Hyaluronic Acid; D008954:Models, Biological
chemical_list: D000464:Alginates; D001672:Biocompatible Materials; D002264:Carboxylic Acids; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D005780:Gelatin; D006820:Hyaluronic Acid; D002118:Calcium