Influence of carboxylate ions containing polymers on calcification: in vitro study.
Calcification of implant or surrounding tissues represents an important complication of its function. The role of the molecular structure of a model hydrogel on the calcification is studied here in a simple in vitro, cell free system. The results show that-COO- containing polymers have an inhibitory effect on Ca2+ crystal formation. This process seems to be unspecific, because the polymers of different structure and origin have an inhibitory effect. However, its efficiency is related to a different extent of Ca2+ binding capacity of distinct polymers.
Smetana
K
K
Institute of Anatomy, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
Stol
M
M
Novák
M
M
Danes
J
J
D000464:Alginates; D001672:Biocompatible Materials / Q000009:adverse effects; D002114:Calcinosis; D002118:Calcium; D002264:Carboxylic Acids; D002474:Cell-Free System; D005780:Gelatin / Q000737:chemistry*; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D006820:Hyaluronic Acid; D008954:Models, Biological
D000464:Alginates; D001672:Biocompatible Materials; D002264:Carboxylic Acids; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D005780:Gelatin; D006820:Hyaluronic Acid; D002118:Calcium