title: Lump detection is enhanced in silicone breast models simulating postmenopausal breast tissue.
abstract: We varied the softness and nodularity of silicone breast models to assess the effects of age-related breast tissue characteristics on lump detection. In two sets of six silicone breast models manufactured to simulate premenopausal and postmenopausal breast tissue, respectively, 82 internal medicine attending and housestaff physicians more readily detected lumps among models simulating older breast tissue. The proportion of models with one or more false-positive findings was higher among models simulating postmenopausal breast tissue. We conclude that age-related changes in breast tissue most likely contribute to the higher sensitivity of clinical breast examination in older women.
authors.affiliation: Division of General Internal Medicine, Northwestern University Medical School, Chicago, Illinois, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: McDermott
authors.forename: N C
authors.initials: NC
authors.lastname: Dolan
authors.forename: J
authors.initials: J
authors.lastname: Huang
authors.forename: D
authors.initials: D
authors.lastname: Reifler
authors.forename: A W
authors.initials: AW
authors.lastname: Rademaker
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D017698:Postmenopause; D017697:Premenopause; D019736:Prostheses and Implants; D012680:Sensitivity and Specificity; D012826:Silicone Elastomers / Q000627:therapeutic use
chemical_list: D012826:Silicone Elastomers