title: Perinatal manifestations of idiopathic long QT syndrome.
abstract: A neonate who had presented with sustained irregular heart rate during labor was found to have QT prolongation and repetitive polymorphic ventricular tachycardia (torsades de pointes) postnatally. Propranolol and propafenone successfully controlled the ventricular arrhythmias. Follow-up electrocardiograms and Holter records show persistent QT prolongation, bizarre T waves, and intermittent episodes of T wave alternans. On propranolol monotherapy the boy is thriving and completely free of ventricular arrhythmias. In the rare case of long QT syndrome in the neonate, early detection and therapy are mandatory to prevent ventricular arrhythmias and sudden death.
authors.affiliation: Department of Pediatric Cardiology, Children's Hospital, University of Graz, Austria.
authors.forename: C J
authors.initials: CJ
authors.lastname: Mache
authors.forename: A
authors.initials: A
authors.lastname: Beitzke
authors.forename: M
authors.initials: M
authors.lastname: Haidvogl
authors.forename: A
authors.initials: A
authors.lastname: Gamillscheg
authors.forename: C
authors.initials: C
authors.lastname: Suppan
authors.forename: J I
authors.initials: JI
authors.lastname: Stein
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000627:therapeutic use; D004562:Electrocardiography; D015716:Electrocardiography, Ambulatory; D005315:Fetal Diseases / Q000175:diagnosis*; D006801:Humans; D007231:Infant, Newborn; D008133:Long QT Syndrome / Q000150:complications / Q000151:congenital / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D011296:Prenatal Diagnosis; D011405:Propafenone / Q000008:administration & dosage / Q000627:therapeutic use; D011433:Propranolol / Q000008:administration & dosage / Q000627:therapeutic use; D017180:Tachycardia, Ventricular / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology
chemical_list: D000889:Anti-Arrhythmia Agents; D011405:Propafenone; D011433:Propranolol