Lithiation-based silylation and stannylation of 6-chloro-9-(beta-D-ribofuranosyl)purine.
Reaction of the lithiated species of 9-(2,3,5-tris-O-tert-butyldimethylsilyl-beta-D-ribofuranosyl)-6-chloropu rine with Me3SiCl or Bu3SnCl was found to furnish the corresponding C-2 substituted product, as a result of silyl or stannyl migration from C-8 to C-2 position.
Katoh
K
K
School of Pharmaceutical Sciences, Showa University, Japan.
Hayakawa
H
H
Tanaka
H
H
Kumamoto
H
H
Miyasaka
T
T
D004563:Electrochemistry; D007202:Indicators and Reagents; D008094:Lithium / Q000737:chemistry; D008722:Methods; D015394:Molecular Structure; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry*; D012825:Silicon / Q000737:chemistry; D014001:Tin / Q000737:chemistry
D007202:Indicators and Reagents; D011684:Purine Nucleosides; C024008:6-chloropurine riboside; D014001:Tin; D008094:Lithium; D012825:Silicon