title: Field evaluation of arthropod repellents, deet and a piperidine compound, AI3-37220, against Anopheles funestus and Anopheles arabiensis in western Kenya.
abstract: A field evaluation of the repellents N,N-diethyl-3-methylbenzamide (deet) and 1-(3-cyclohexen-1-yl-carbonyl)-2-methylpiperidine (AI3-37220, a piperidine compound) was conducted against Anopheles funestus and An. arabiensis in Kenya. Both repellents provided significantly more protection (P < 0.001) than the ethanol control. AI3-37220 was significantly more effective (P < 0.001) than deet in repelling both species of mosquitoes. After 9 h, 0.1 mg/cm2 of AI3-37220 provided 89.8% and 71.1% protection against An. arabiensis and An. funestus, respectively. Deet provided > 80% protection for only 3 h, and protection rapidly decreased after this time to 60.2% and 35.1% for An. arabiensis and An. funestus, respectively, after 9 h. Anopheles funestus was significantly less sensitive (P < 0.001) to both repellents than An. arabiensis. The results of this study indicate that AI3-37220 is more effective than deet in repelling anopheline mosquitoes in western Kenya.
authors.affiliation: United States Army Center for Health Promotion, Preventive Medicine, Divisional Support Activity-West, Aurora, CO 80045-5001, USA.
authors.forename: T W
authors.initials: TW
authors.lastname: Walker
authors.forename: L L
authors.initials: LL
authors.lastname: Robert
authors.forename: R A
authors.initials: RA
authors.lastname: Copeland
authors.forename: A K
authors.initials: AK
authors.lastname: Githeko
authors.forename: R A
authors.initials: RA
authors.lastname: Wirtz
authors.forename: J I
authors.initials: JI
authors.lastname: Githure
authors.forename: T A
authors.initials: TA
authors.lastname: Klein
mesh_terms: D000328:Adult; D000818:Animals; D000852:Anopheles; D003671:DEET; D006801:Humans; D007302:Insect Repellents; D007630:Kenya; D008297:Male; D009032:Mosquito Control / Q000379:methods*; D010880:Piperidines
chemical_list: D007302:Insect Repellents; D010880:Piperidines; D003671:DEET; C075892:1-(3-cyclohexen-1-ylcarbonyl)-2-methylpiperidine