title: Apo-E genotype and verbal deficits in Alzheimer's disease.
abstract: Apo-E genotype was not significantly related to cognitive performance in 157 Alzheimer's disease patients. However, patients homozygous for the epsilon 4 allele appeared most impaired on global cognition but least impaired on language measures. Further study with larger samples may reveal that Apo-E genotype accounts for some of the variability in cognitive deficits observed in Alzheimer's disease.
authors.affiliation: Department of Psychiatry/Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. xeno@mvx.grc.nia.nih.gov
authors.forename: D X
authors.initials: DX
authors.lastname: Rasmusson
authors.forename: G
authors.initials: G
authors.lastname: Dal Forno
authors.forename: J
authors.initials: J
authors.lastname: Brandt
authors.forename: A C
authors.initials: AC
authors.lastname: Warren
authors.forename: J
authors.initials: J
authors.lastname: Troncoso
authors.forename: C
authors.initials: C
authors.lastname: Lyketsos
mesh_terms: D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics* / Q000523:psychology*; D001057:Apolipoproteins E / Q000235:genetics / Q000378:metabolism*; D003072:Cognition Disorders / Q000235:genetics* / Q000523:psychology*; D005260:Female; D005838:Genotype; D006801:Humans; D007806:Language Disorders / Q000235:genetics* / Q000523:psychology*; D007807:Language Tests; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests
chemical_list: D001057:Apolipoproteins E