title: A genetic linkage map of the rat derived from recombinant inbred strains.
abstract: We have constructed a genetic linkage map in the rat by analyzing the strain distribution patterns of 500 genetic markers in a large set of recombinant inbred strains derived from the spontaneously hypertensive rat and the Brown-Norway rat (HXB and BXH recombinant inbred strains). 454 of the markers could be assigned to specific chromosomes, and the amount of genome covered by the mapped markers was estimated to be 1151 centimorgans. By including a variety of morphologic, biochemical, immunogenetic, and molecular markers, the current map integrates and extends existing linkage data and should facilitate rat gene mapping and genetic studies of hypertension and other complex phenotypes of interest in the HXB and BXH recombinant inbred strains.
authors.affiliation: Institute of Physiology, Czech Academy of Sciences, Prague.
authors.forename: M
authors.initials: M
authors.lastname: Pravenec
authors.forename: D
authors.initials: D
authors.lastname: Gauguier
authors.forename: J J
authors.initials: JJ
authors.lastname: Schott
authors.forename: J
authors.initials: J
authors.lastname: Buard
authors.forename: V
authors.initials: V
authors.lastname: Kren
authors.forename: V
authors.initials: V
authors.lastname: Bílá
authors.forename: C
authors.initials: C
authors.lastname: Szpirer
authors.forename: J
authors.initials: J
authors.lastname: Szpirer
authors.forename: J M
authors.initials: JM
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Huang
authors.forename: E
authors.initials: E
authors.lastname: St Lezin
authors.forename: M A
authors.initials: MA
authors.lastname: Spence
authors.forename: P
authors.initials: P
authors.lastname: Flodman
authors.forename: M
authors.initials: M
authors.lastname: Printz
authors.forename: G M
authors.initials: GM
authors.lastname: Lathrop
authors.forename: G
authors.initials: G
authors.lastname: Vergnaud
authors.forename: T W
authors.initials: TW
authors.lastname: Kurtz
mesh_terms: D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D017931:DNA Primers; D005260:Female; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D051381:Rats; D011914:Rats, Inbred BN; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains / Q000235:genetics*; D011995:Recombination, Genetic
chemical_list: D017931:DNA Primers