Distinctive developmental origins and specificities of the CD5+ B-cell subset.
In this review we present our recent work defining the pathway of B-cell development in the adult bone marrow of the mouse. We next present similarities and contrasts between fetal and adult B lymphopoiesis. Finally, considering the striking biases in specificity and V-gene usage between the progeny of fetal B lymphopoiesis, CD5+ B cells, and the bulk of adult-derived CD5- B cells, we suggest a model for developmentally distinct generation of this subset.
Hardy
R R
RR
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 1911
Li
Y S
YS
Hayakawa
K
K
D000818:Animals; D016175:B-Lymphocyte Subsets / Q000502:physiology*; D001854:Bone Marrow Cells; D018956:CD5 Antigens / Q000032:analysis*; D005803:Genes, Immunoglobulin; D006410:Hematopoiesis; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000235:genetics
D018956:CD5 Antigens; D007135:Immunoglobulin Variable Region