Calcitonin gene-related peptide: vasoactive effects and potential therapeutic role.
1. The cardiovascular biology of calcitonin gene-related peptide (CGRP) and the structurally related peptides amylin and adrenomedullin are briefly reviewed. 2. CGRP is a potent and long-lasting vasodilator; its possible role in disease, and the therapeutic potential of CGRP receptor agonists and antagonists is discussed.
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Pharmacology Group, King's College, London, England.
Cambridge
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D000595:Amino Acid Sequence; D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology* / Q000627:therapeutic use*; D000077221:Calcitonin Gene-Related Peptide Receptor Antagonists; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008969:Molecular Sequence Data; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000819:agonists; D014665:Vasodilator Agents / Q000494:pharmacology* / Q000627:therapeutic use
D000077221:Calcitonin Gene-Related Peptide Receptor Antagonists; D018015:Receptors, Calcitonin Gene-Related Peptide; D014665:Vasodilator Agents; D015740:Calcitonin Gene-Related Peptide