Absence of restricted T cell receptor V beta repertoire in skin lesions of a patient with both psoriasis vulgaris and lichen planus.
In a patient with both lichen planus and psoriasis, and suffering from hepatitis C virus infection, we examined the T cell receptor (TCR) Vb repertoire by reverse transcriptase polymerase chain reaction in skin lesions from psoriasis and lichen planus. A variety of rearranged variable TCR genes was found in the skin lesions, and the TCR Vb repertoire of the infiltrating T cells was not restricted. Although different patterns of expression were observed in the two lesions, TCR Vb 2 and 7 were commonly found.
Yamamoto
T
T
Tokyo Medical and Dental University, School of Medicine, Tokyo, Japan.
Katayama
I
I
Nishioka
K
K
D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D006526:Hepatitis C / Q000150:complications / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008010:Lichen Planus / Q000150:complications / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011565:Psoriasis / Q000150:complications / Q000276:immunology / Q000473:pathology*; D011948:Receptors, Antigen, T-Cell / Q000032:analysis*
D011948:Receptors, Antigen, T-Cell