[Effect of low doses of irradiation on synthesis of DNA, RNA and proteins in cerebral cortex cells].
Short-term external gamma-irradiation (0.1-5 Gy) and long-term (30 days) internal irradiation of rats by everyday intake of 137Cs and 85Sr isotopes into their organisms induced, most probably, irreversible changes in the level of synthetic processes in the rat brain cortex neurons. Synthesis of RNA and proteins decreased significantly after 2h-long irradiation. Irradiation which lasted for 30 days has somewhat shortened the level of reparative DNA synthesis and has almost twice increased RNA synthesis. It was accompanied by changes in the relative activity of RNA-polymerases A, B and C. Doses over 1 Gy have induced an exponential delay of dose-dependent changes in the level of synthetic processes.
Protas
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AF
D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism / Q000528:radiation effects*; D004247:DNA / Q000096:biosynthesis*; D012321:DNA-Directed RNA Polymerases / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D009457:Neuroglia / Q000378:metabolism / Q000528:radiation effects; D009474:Neurons / Q000378:metabolism / Q000528:radiation effects; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar
D009419:Nerve Tissue Proteins; D012313:RNA; D004247:DNA; D012321:DNA-Directed RNA Polymerases