title: Long-term habituation of brain evoked potential responses and pituitary-adrenal secretion with repeated (placebo) testing.
abstract: To study whether changes in late auditory evoked potentials (AEPs) and/or in stress-sensitive hormones of the hypothalamic-pituitary-adrenal (HPA) system take place between a first and a second placebo experiment and if so, whether these changes are possibly related to each other, we conducted two identical placebo sessions (2 ml 0.9% saline) and one cortisol session (50 mg) with 10 subjects on three different days. Plasma cortisol concentrations were significantly higher at the beginning of the first placebo experiment than the second, with a concordant decrease of plasma adrenocorticotropin hormone (ACTH) concentrations. In the AEP domain, a consistently lower P2 amplitude was observed in the first session. Since the change in late auditory processing could not be demonstrated after exogenous administration of cortisol, a direct mediation through an elevation of plasma cortisol concentrations or indirect mediation through a decrease of plasma ACTH concentrations seems unlikely. We rather propose that other stress-sensitive mechanisms, such as CCK, might account for the novelty-induced P2 amplitude lowering.
authors.affiliation: Max Planck Institute of Psychiatry, Munich, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Hartmann
authors.forename: K
authors.initials: K
authors.lastname: Krumrey
authors.forename: T
authors.initials: T
authors.lastname: Dietl
authors.forename: L
authors.initials: L
authors.lastname: Vogl
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
authors.forename: G
authors.initials: G
authors.lastname: Dirlich
authors.forename: M
authors.initials: M
authors.lastname: Heuser-Link
mesh_terms: D000161:Acoustic Stimulation; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D001143:Arousal / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology; D004292:Dominance, Cerebral / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006185:Habituation, Psychophysiologic / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000097:blood*; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D008297:Male; D010913:Pituitary-Adrenal System / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D012815:Signal Processing, Computer-Assisted
chemical_list: D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone