Molecular cloning of the N-terminus of GTBP.
Defects in mismatch repair genes cause the genetic instability characteristic of hereditary nonpolyposis colorectal cancer and a subset of sporadic colon tumors. The newest member of the mismatch repair gene family, GTBP, has recently been identified as a partial cDNA. Here, we describe the isolation of its 5' terminus, allowing definition of the entire coding region. Several polymorphisms within the 5' end were identified and are presented.
Nicolaides
N C
NC
Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA.
Palombo
F
F
Kinzler
K W
KW
Vogelstein
B
B
Jiricny
J
J
D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA; D004268:DNA-Binding Proteins / Q000235:genetics*; D006367:HeLa Cells; D006801:Humans; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic
D004268:DNA-Binding Proteins; C094443:G-T mismatch-binding protein; D004247:DNA