title: In vivo MR imaging and spectroscopy using hyperpolarized 129Xe.
abstract: Hyperpolarized 129Xe has been used to obtain gas phase images of mouse lung in vivo, showing distinct ventilation variation as a function of the breathing cycle. Spectra of 129Xe in the thorax show complex structure in both the gas phase (-4 to 3 ppm) and tissue-dissolved (190-205 ppm) regions. The alveolar gas peak shows correlated intensity and frequency oscillations, both attributable to changes in lung volume during breathing. The two major dissolved peaks near 195-200 ppm are attributed to lung parenchyma and to blood; they reach maximum intensity in 5-10 s and decay with an apparent T1 of 30 s. Another peak at 190 ppm takes 20-30 s to reach maximum; this must represent other well-vascularized tissue (e.g., heart and other muscles) in the thorax. The maximum integrated area of the tissue components reaches 30-80% of the maximum alveolar gas area, indicating that imaging at tissue frequencies can be achieved.
authors.affiliation: Department of Radiology, State University of New York at Stony Brook 11794-8460, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Wagshul
authors.forename: T M
authors.initials: TM
authors.lastname: Button
authors.forename: H F
authors.initials: HF
authors.lastname: Li
authors.forename: Z
authors.initials: Z
authors.lastname: Liang
authors.forename: C S
authors.initials: CS
authors.lastname: Springer
authors.forename: K
authors.initials: K
authors.lastname: Zhong
authors.forename: A
authors.initials: A
authors.lastname: Wishnia
mesh_terms: D000818:Animals; D008168:Lung / Q000502:physiology*; D008176:Lung Volume Measurements; D008279:Magnetic Resonance Imaging / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods; D051379:Mice; D012119:Respiration / Q000502:physiology*; D014979:Xenon Isotopes
chemical_list: D014979:Xenon Isotopes