8-Methylguanine-containing oligonucleotides: useful structural constraint for Z form DNA.
The preparation and thermodynamic property of 8-methylguanine (8mG)-containing oligonucleotides were described. It was found that the introduction of a methyl group at the guanine C8 position remarkably stabilizes the Z conformation of short oligonucleotides of a variety of base sequences under low salt conditions.
Kawai
K
K
Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Japan.
Sugiyama
H
H
Fujimoto
K
K
Saito
I
I
D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D006147:Guanine / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D013816:Thermodynamics
D009838:Oligodeoxyribonucleotides; C066771:8-methylguanine; D006147:Guanine; D004247:DNA