Inherited predisposition to colorectal neoplasia.
This review concentrates on the genetics of colorectal neoplasia. There is now a greater understanding of the molecular genetics of the inherited condition familial adenomatous polyposis and of the adenoma-carcinoma sequence in non-inherited colorectal cancer. We consider the evidence that sporadic colorectal cancer may also have an underlying genetic susceptibility.
Stephenson
B M
BM
Cardiff Royal Infirmary.
Hall
N R
NR
Finan
P J
PJ
Bishop
T
T
D011125:Adenomatous Polyposis Coli / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D017491:Genes, APC; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D010375:Pedigree; D012307:Risk Factors