[CFTR as cAMP-dependent chloride channels and as cAMP-dependent regulator of sodium channels].
Cystic fibrosis transmembrane conductance regulator (CFTR) is mutated in cystic fibrosis (CF) patients. It has been established that CFTR functions as a cAMP-dependent chloride channel. Therefore mutation of CFTR causes the abnormality of the chloride ion secretion. Furthermore, it has been shown recently that CFTR functions as cAMP-dependent negative regulator of sodium channels. The evidence accounts an abnormally high rate of sodium ion in the airway epithelia of the CF patients.
Tohyama
M
M
Department of Anatomy and Neuroscience, Osaka University Medical School.
D018118:Chloride Channels / Q000502:physiology*; D000242:Cyclic AMP / Q000502:physiology*; D003550:Cystic Fibrosis / Q000378:metabolism; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000502:physiology*; D006801:Humans; D012137:Respiratory System / Q000378:metabolism; D015222:Sodium Channels / Q000502:physiology*
C505032:CFTR protein, human; D018118:Chloride Channels; D015222:Sodium Channels; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D000242:Cyclic AMP