title: Effect of central glucagon infusion on macronutrient selection in rats.
abstract: Compared were the light-dark pattern of absolute energy intake and macronutrient selection of male Wistar rats intracerebroventricularly infused with glucagon (5 ng/h) or saline for 7 days in a three-way selection of macronutrients. Glucagon infusion induced a decrease in 24 h and nocturnal energy intake, whereas no significant change in kcal intake accompanied vehicle infusion. The decrease in kcal intake was due to a suppression of nocturnal ingestion of carbohydrate. This parameter was left unaffected with central vehicle infusion. Glucagon-infused rats had a significantly lower body weight gain than those infused with vehicle. Our study supports the hypothesis of central glucagon's suppressive effect on food intake, but reveals that the latter reflects a lower disposition to eat carbohydrate during the dark phase. The present work emphasizes the role of glucagon in the circadian regulation of carbohydrate intake.
authors.affiliation: Department of Food Science and Nutrition, Nara Women's University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Komenami
authors.forename: F H
authors.initials: FH
authors.lastname: Su
authors.forename: L
authors.initials: L
authors.lastname: Thibault
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology; D002149:Energy Intake / Q000502:physiology*; D005518:Food Preferences / Q000502:physiology*; D005934:Glucagon / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005934:Glucagon