Is it possible to trigger collagen synthesis by electric current in skin wounds?
The effect of direct micro currents on collagen synthesis in wound healing on the 3rd day of wounding has been examined in rabbit skin. Two circular skin wounds were formed bilaterally on the gluteal region and current was applied to one of the wounds and the other was taken as the control with placebo electrode on it, the current intensities being 200 microA and 400 microA and application time 72 hrs with 8 hr/day. The hydroxyproline content was found to be increased in wound tissue at the end of 72 hrs of applying current which indicated that collagen synthesis is promoted by electric current.
Canseven
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AG
Gazi University, Faculty of Medicine, Department of Biophysics, Ankara, Turkey.
Atalay
N S
NS
D000704:Analysis of Variance; D000818:Animals; D003094:Collagen / Q000096:biosynthesis*; D004558:Electric Stimulation; D008297:Male; D011817:Rabbits; D012867:Skin / Q000293:injuries* / Q000378:metabolism*; D014945:Wound Healing; D014947:Wounds and Injuries / Q000378:metabolism* / Q000503:physiopathology
D003094:Collagen