Lipid peroxidation: the role of Ca2+ and protection by calcinine.
When calcinine (A-23187) (2 microM), a known Ca2+ ionophore, is present, a significant protection is observed to a mitochondrial suspension undergoing lipid peroxidation by Fe(2+)-citrate complex. A-23187 can remove Ca2+, which seems to have an important role in the lipid peroxidation process, from its 'lesive sites' and consequently preventing the damage. This information has importance in terms of knowing the mechanisms and avoiding the damages of lipid peroxidation that occur in some pathological cases such as tumor promotion and hemochromatosis.
Pereira
R S
RS
Department of Biochemistry, Universidade Estadual Paulista (UNESP), Araraquara, São Paulo, Brazil.
D000818:Animals; D000001:Calcimycin / Q000378:metabolism / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D007476:Ionophores / Q000378:metabolism / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism
D007476:Ionophores; D017382:Reactive Oxygen Species; D000001:Calcimycin; D002118:Calcium