title: Protein A immunoadsorption column versus splenectomy in the treatment of steroid-resistant immune thrombocytopenic purpura. A cost-effectiveness analysis.
abstract: The protein A immunoadsorption column is a new treatment for immune thrombocytopenic purpura (ITP). We used a decision-analytic approach with a Markov process to model the cost effectiveness of this treatment compared with splenectomy for steroid-resistant ITP patients. Data informing the model were obtained from published literature, a panel of physicians, and public databases. We found initial treatment with the protein A immunoadsorption column to be less expensive and more effective than initial treatment with splenectomy.
authors.forename: K
authors.initials: K
authors.lastname: Kunz
authors.forename: M
authors.initials: M
authors.lastname: Kuppermann
authors.forename: T
authors.initials: T
authors.lastname: Bowe
authors.forename: A
authors.initials: A
authors.lastname: Williamson
authors.forename: P
authors.initials: P
authors.lastname: Mazonson
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D003131:Combined Modality Therapy; D003362:Cost-Benefit Analysis; D003661:Decision Support Techniques; D004351:Drug Resistance; D017048:Health Care Costs; D006801:Humans; D007163:Immunosorbent Techniques / Q000191:economics*; D008390:Markov Chains; D018803:Models, Economic; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000191:economics* / Q000628:therapy; D019057:Quality-Adjusted Life Years; D013156:Splenectomy / Q000191:economics*; D013205:Staphylococcal Protein A
chemical_list: D000305:Adrenal Cortex Hormones; D013205:Staphylococcal Protein A