Interferon-gamma-secreting cells in multiple sclerosis patients treated with interferon beta-1b.
Fifteen percent of multiple sclerosis patients about to be treated with interferon beta-1b exhibited elevated numbers of circulating interferon-gamma-secreting cells, defined as a value that exceeded the mean value for healthy controls by more than two standard deviations. Sixty percent of patients receiving the drug exhibited elevated interferon-gamma-secreting cell numbers during their first 2 months of treatment. Values normalized after 3 months. Prednisone treatment during the first month on the drug prevented the interferon-gamma-secreting cell surge.
Dayal
A S
AS
Department of Neurology, University of Chicago, IL 60637, USA.
Jensen
M A
MA
Lledo
A
A
Arnason
B G
BG
D000293:Adolescent; D000328:Adult; D001773:Blood Cells / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006801:Humans; D016899:Interferon-beta / Q000009:adverse effects* / Q000627:therapeutic use; D007371:Interferon-gamma / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000628:therapy*; D011241:Prednisone / Q000627:therapeutic use; D012016:Reference Values; D013997:Time Factors
D016899:Interferon-beta; D007371:Interferon-gamma; D011241:Prednisone