Biological activity of 4-(4-bromophenyl)-thiosemicarbazide.
The two molecules (A and B) in the asymmetric unit of the title compound, C7H8BrN3S, display different conformation. In both molecules, the S atom is trans to the NH2 group. The Br atoms of the two molecules approach each other at a distance of 3.573(2) A. The crystal structure of the bromine compound is isomorphous with that of its chlorine analogue. In the crystal structure, intramolecular N-H...N and intermolecular N-H...S hydrogen bonds help stabilize the molecular packing. The increased antibacterial activity of the title compound compared to that of its chlorine analogue may be attributed to the increase in electron density on the hydrazinic end of the thiosemicarbazide chain.
Seth
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S
Department of Physics, Presidency College, Calcutta, West Bengal, India.
Biswas
A
A
Banerjee
A
A
Chattopadhyay
S K
SK
Ghosh
S
S
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D012663:Semicarbazides / Q000737:chemistry* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D012663:Semicarbazides; C102066:4-(4-bromophenyl)thiosemicarbazide