Abnormalities of the vitamin D receptor in uraemia.
The 1,25-dihydroxyvitamin D3 (1,25(OH)2 D3) receptor mediates many of the actions of 1,25(OH)2D3 in cells of target tissues. Abnormalities in vitamin D receptor concentration and regulation exist in tissues of subjects with chronic renal failure and end-stage renal disease. There is evidence that inhibitors of vitamin D receptor-1,25(OH)2D3 binding and 1,25(OH)2D3 action are present in dialysates and sera of individuals with end-stage renal disease. The biological significance of decreased vitamin D receptor number and altered vitamin D receptor regulation in uraemia is unclear at present as responses to 1,25(OH)2D3 in uraemia have not been systematically compared with responses in normal subjects.
Kumar
R
R
Department of Medicine, Mayo Clinic/Foundation, Rochester, MN 55905, USA.
D002117:Calcitriol / Q000494:pharmacology; D006801:Humans; D012333:RNA, Messenger / Q000032:analysis; D018167:Receptors, Calcitriol / Q000032:analysis* / Q000737:chemistry / Q000235:genetics; D014511:Uremia / Q000378:metabolism*
D012333:RNA, Messenger; D018167:Receptors, Calcitriol; D002117:Calcitriol