Pulmonary toxoplasmosis after allogeneic bone marrow transplantation: case report and review.
We report an isolated case of toxoplasma pneumonitis in a 27-year-old man. This acute infection occurred after induction chemotherapy for AMLo relapsing 3 years post-allogeneic BMT. The detection of Toxoplasma gondii in the bronchoalvolar lavage (BAL), by culture in fibroblast cell line MRC5 enabled us to make the diagnosis. Pyrimethamine and sulfadiazine were effective.
Saad
R
R
Department of Hematology, CHU, Angers, France.
Vincent
J F
JF
Cimon
B
B
de Gentile
L
L
Francois
S
S
Bouachour
G
G
Ifrah
N
N
D000208:Acute Disease; D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D001782:Blood Donors; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D001992:Bronchoalveolar Lavage Fluid / Q000469:parasitology; D003131:Combined Modality Therapy; D006801:Humans; D016867:Immunocompromised Host; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D007951:Leukemia, Myeloid / Q000150:complications / Q000188:drug therapy / Q000628:therapy; D008174:Lung Diseases, Parasitic / Q000276:immunology / Q000635:transmission*; D008297:Male; D051379:Mice; D009364:Neoplasm Recurrence, Local; D011739:Pyrimethamine / Q000627:therapeutic use; D019233:Retreatment; D013411:Sulfadiazine / Q000627:therapeutic use; D014019:Tissue Donors; D014122:Toxoplasma / Q000276:immunology; D014123:Toxoplasmosis / Q000188:drug therapy / Q000276:immunology / Q000635:transmission*; D065227:Transfusion Reaction; D014184:Transplantation, Homologous / Q000009:adverse effects
D000913:Antibodies, Protozoan; D000981:Antiprotozoal Agents; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D013411:Sulfadiazine; D011739:Pyrimethamine