title: Local cerebral glucose metabolism in patients with long-term behavioral and cognitive deficits following mild traumatic brain injury.
abstract: A retrospective study of 20 patients with mild traumatic brain injury (MTBI) examined brain regions of interest by comparing [18F]-2-deoxyglucose PET, neuropsychological test results, and continuing behavioral dysfunction. Abnormal local cerebral metabolic rates (rLCMs) were most prominent in midtemporal, anterior cingulate, precuneus, anterior temporal, frontal white, and corpus callosum brain regions. Abnormal rLCMs were significantly correlated statistically with 1) overall clinical complaints, most specifically with inconsistent attention/concentration and 2) overall neuropsychological test results. The authors conclude that 1) even mild TBI may result in continuing brain behavioral deficits; 2) PET can help elucidate dysfunctional brain circuitry in neurobehavioral disorders; and 3) specific brain areas may correlate with deficits in daily neurobehavioral functioning and neuropsychological test findings.
authors.affiliation: Psychiatry Service, Sepulveda Veterans Administration Medical Center, California, USA.
authors.forename: H
authors.initials: H
authors.lastname: Gross
authors.forename: A
authors.initials: A
authors.lastname: Kling
authors.forename: G
authors.initials: G
authors.lastname: Henry
authors.forename: C
authors.initials: C
authors.lastname: Herndon
authors.forename: H
authors.initials: H
authors.lastname: Lavretsky
mesh_terms: D000293:Adolescent; D000328:Adult; D000963:Antimetabolites; D001923:Brain Chemistry / Q000502:physiology*; D001930:Brain Injuries / Q000378:metabolism* / Q000523:psychology*; D002648:Child; D003072:Cognition Disorders / Q000378:metabolism* / Q000523:psychology*; D003847:Deoxyglucose; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000378:metabolism* / Q000523:psychology*; D008875:Middle Aged; D019964:Mood Disorders / Q000209:etiology / Q000523:psychology; D009483:Neuropsychological Tests; D012189:Retrospective Studies; D014055:Tomography, Emission-Computed
chemical_list: D000963:Antimetabolites; D003847:Deoxyglucose; D005947:Glucose