title: Effects of ebelactone B, a lipase inhibitor, on intestinal fat absorption in the rat.
abstract: Ebelactones A and B, natural products from Streptomyces aburaviensis are potent inhibitors of pancreatic lipase. Lipase is the key enzyme required for the absorption of dietary triglycerides (TG). Ebelactone B inhibited, in a dose-dependent manner, the intestinal absorption of fat after fat-feeding in the rat. The most effective inhibition was observed when the inhibitor was administered at 60 min prior to fat-feeding. When ebelactone B (10 mg/kg) was administered, the serum levels of TG (58%) and cholesterol (36%) were decreased. Since ebelactone B effectively inhibitors absorption of dietary fat, if may provide a promising means for prophylaxis or therapeutics of hyperlipidemia and obesity.
authors.affiliation: Showa College of Pharmaceutical Science, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nonaka
authors.forename: H
authors.initials: H
authors.lastname: Ohtaki
authors.forename: E
authors.initials: E
authors.lastname: Ohtsuka
authors.forename: T
authors.initials: T
authors.lastname: Kocha
authors.forename: T
authors.initials: T
authors.lastname: Fukuda
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
authors.forename: T
authors.initials: T
authors.lastname: Aoyagi
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D004032:Diet; D004950:Esterases / Q000037:antagonists & inhibitors; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption / Q000187:drug effects*; D007783:Lactones / Q000494:pharmacology; D008049:Lipase / Q000037:antagonists & inhibitors* / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D015394:Molecular Structure; D010179:Pancreas / Q000201:enzymology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
chemical_list: D007783:Lactones; D008074:Lipoproteins; D014280:Triglycerides; C030795:ebelactone B; C030794:ebelactone A; D002784:Cholesterol; D004950:Esterases; D008049:Lipase