Protection of mice against fatal pneumococcal challenge by immunization with pneumococcal surface adhesin A (PsaA).
Pneumococcal surface adhesin A (PsaA) is a 37-kDa surface protein present on Streptococcus pneumoniae having significant homology with fimbrial adhesion proteins. Immunization of CBA/CaHNJ Xid mice with PsaA using either complete Freund's or TiterMax adjuvants significantly protected mice against heterologous intravenous challenge with type 3 pneumococcal strain WU2 at doses up to 45 times the LD50. The results indicate that PsaA warrants further evaluation as a vaccine candidate for human pneumococcal disease.
Talkington
D F
DF
Division of Bacterial and Mycotic Diseases, Center for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Brown
B G
BG
Tharpe
J A
JA
Koenig
A
A
Russell
H
H
D018829:Adhesins, Bacterial; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D001426:Bacterial Proteins / Q000276:immunology*; D015153:Blotting, Western; D008074:Lipoproteins; D026901:Membrane Transport Proteins; D051379:Mice; D008808:Mice, Inbred CBA; D045331:Photosystem I Protein Complex; D011008:Pneumococcal Infections / Q000276:immunology / Q000517:prevention & control*; D013047:Specific Pathogen-Free Organisms; D013296:Streptococcus pneumoniae / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology*
D018829:Adhesins, Bacterial; D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D008074:Lipoproteins; D026901:Membrane Transport Proteins; D045331:Photosystem I Protein Complex; C085000:PsaA protein, Streptococcus; D014614:Vaccines, Synthetic; C051592:pneumococcal surface protein A