title: Myelodysplasia and acute myeloid leukemia occurring after autologous bone marrow transplantation for lymphoma.
abstract: Secondary hematopoietic disease manifesting as acute myeloid leukemia, myelodysplastic syndrome or clonal karyotypic abnormalities, has been recently recognized as a relatively frequent and potentially serious complication of autologous bone marrow transplantation for both Hodgkin's disease and non-Hodgkin's lymphoma. The available evidence suggests the disease results primarily from repeated exposure of the host stem cells to therapeutic agents before the time of transplant, but a conspiratory role for the transplantation procedure itself cannot be entirely excluded. Strategies to decrease the incidence of secondary hematopoietic disease include earlier stem cell harvest and/or transplantation, and the performance of screening karyotypic studies on the bone marrow prior to autologous grafting.
authors.affiliation: Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: S T
authors.initials: ST
authors.lastname: Traweek
authors.forename: M L
authors.initials: ML
authors.lastname: Slovak
authors.forename: A P
authors.initials: AP
authors.lastname: Nademanee
authors.forename: R K
authors.initials: RK
authors.lastname: Brynes
authors.forename: J C
authors.initials: JC
authors.lastname: Niland
authors.forename: S J
authors.initials: SJ
authors.lastname: Forman
mesh_terms: D000208:Acute Disease; D000970:Antineoplastic Agents / Q000009:adverse effects; D001853:Bone Marrow / Q000473:pathology; D001856:Bone Marrow Examination; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005500:Follow-Up Studies; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000209:etiology* / Q000517:prevention & control; D007953:Leukemia, Radiation-Induced / Q000209:etiology; D008223:Lymphoma / Q000150:complications / Q000235:genetics / Q000628:therapy*; D009190:Myelodysplastic Syndromes / Q000209:etiology*; D018365:Neoplasm, Residual; D016609:Neoplasms, Second Primary / Q000209:etiology* / Q000517:prevention & control; D014411:Neoplastic Stem Cells / Q000637:transplantation; D011878:Radiotherapy / Q000009:adverse effects; D012189:Retrospective Studies; D012307:Risk Factors; D013156:Splenectomy / Q000009:adverse effects; D019172:Transplantation Conditioning / Q000009:adverse effects; D014182:Transplantation, Autologous / Q000009:adverse effects
chemical_list: D000970:Antineoplastic Agents