title: Anti-tumor-promoting activities of triterpenoids from ferns. I.
abstract: To search for possible anti-tumor-promoters (cancer chemopreventive agents), we carried out primary screening of 23 triterpenoid hydrocarbons (1-23) isolated from ferns using an in vitro synergistic assay system. Of these triterpenoids, hop-17(21)-ene (2), neohop-13(18)-ene (3), neohop-12-ene (4), taraxerane (17), multiflor-9(11)-ene (18), multiflor-8-ene (19), glutin-5(10)-ene (21) and taraxastane (23) exhibited remarkable inhibitory effects on Epstein-Barr virus (EBV) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). Further, compounds 2 and 3 exhibited remarkable anti-tumorpromoting effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test using 7,12-dimethybenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.
authors.affiliation: Kyoto Pharmaceutical University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Konoshima
authors.forename: M
authors.initials: M
authors.lastname: Takasaki
authors.forename: H
authors.initials: H
authors.lastname: Tokuda
authors.forename: K
authors.initials: K
authors.lastname: Masuda
authors.forename: Y
authors.initials: Y
authors.lastname: Arai
authors.forename: K
authors.initials: K
authors.lastname: Shiojima
authors.forename: H
authors.initials: H
authors.lastname: Ageta
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D004854:Herpesvirus 4, Human; D051379:Mice; D008813:Mice, Inbred ICR; D010212:Papilloma / Q000473:pathology; D010946:Plants, Medicinal / Q000737:chemistry*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D016588:Anticarcinogenic Agents; D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes