[The antioxidative activity of the tissues and lipids in rats of different ages].
The experiment on white Wistar rats 3-, 12- and 24 months old was carried out to study antioxidative activity in homogenates of the pancreas, adrenal glands, testes, muscles, heart and in lipids isolated from these tissues. The data were obtained in the model of thermal autooxidation of homogenates and lipids as well as during autooxidation of linethol in the presence of the samples studied. kinetics of peroxidation of tissue lipids, their effect on linethol oxidation rate and content of total lipids in the tissues were estimated. Contribution of the lipids to the total antioxidative activity of the tissue varies with age. Tissue properties of the parameters in question are observed as well as active participation of all the tissues studied in the support of the antioxidative homeostasis in the organism. Intensity of the participation depended on the age of animals.
Paranich
A V
AV
Kopylov
A V
AV
Diarra
A
A
Nikipela
O H
OH
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000493:pharmacokinetics; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D008055:Lipids / Q000032:analysis; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
D000975:Antioxidants; D005231:Fatty Acids, Unsaturated; D008055:Lipids; C014642:linethol