title: Emergence of fluoroquinolone-resistant Escherichia coli in fecal flora of cancer patients receiving norfloxacin prophylaxis.
abstract: We studied 122 stool samples collected from 25 patients with hematologic malignancies who received prophylactic norfloxacin. Fecal samples were obtained at admission and twice weekly thereafter during prophylaxis. Fluoroquinolone-resistant Escherichia coli strains were isolated from the feces of 10 (40%) of the patients; two patients had fluoroquinolone-resistant E. coli strains prior to beginning norfloxacin treatment, and in the other eight patients, the strains appeared subsequently. One patient developed fluoroquinolone-resistant E. coli bacteremia after 10 days of norfloxacin administration.
authors.affiliation: Services of Infectious Diseases, University of Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Carratala
authors.forename: A
authors.initials: A
authors.lastname: Fernandez-Sevilla
authors.forename: F
authors.initials: F
authors.lastname: Tubau
authors.forename: M A
authors.initials: MA
authors.lastname: Dominguez
authors.forename: F
authors.initials: F
authors.lastname: Gudiol
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004269:DNA, Bacterial / Q000032:analysis; D004352:Drug Resistance, Microbial / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D005243:Feces / Q000382:microbiology*; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008223:Lymphoma / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000382:microbiology; D009643:Norfloxacin / Q000627:therapeutic use*; D009894:Opportunistic Infections / Q000517:prevention & control*
chemical_list: D000890:Anti-Infective Agents; D004269:DNA, Bacterial; D009643:Norfloxacin