A case of resistant Goodpasture's syndrome and staghorn calculus--treatment with bilateral nephrectomy.
We report the case of a 49-year-old female with severe Goodpasture's syndrome, staghorn calculus, and subacute thyroiditis. Despite the use of a combined therapy with corticosteroid, cyclophosphamide, azathioprine and plasma exchange, we were unable to suppress the disease activity or normalize the anti-glomerular basement membrane (GBM) antibody levels. Disease remission with a parallel reduction in anti-GBM antibody titer was only achieved after sequential bilateral nephrectomy.
Pai
P
P
Regional Renal Unit, Royal Liverpool University Hospital, UK.
Kumar
S
S
Bell
G M
GM
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D019867:Anti-Glomerular Basement Membrane Disease / Q000150:complications / Q000276:immunology / Q000601:surgery*; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007669:Kidney Calculi / Q000150:complications / Q000276:immunology / Q000601:surgery*; D008875:Middle Aged; D009392:Nephrectomy; D010951:Plasma Exchange; D013968:Thyroiditis, Subacute / Q000150:complications
D000305:Adrenal Cortex Hormones; D019268:Antibodies, Antineutrophil Cytoplasmic; D007166:Immunosuppressive Agents