Abnormalities in behavior, learning ability, and the cholinergic system induced by long-term ultraviolet A irradiation of mice.
Behavioral abnormalities, jumping reaction, increase in spontaneous activity abnormal violence, and lethargy were observed in long-term ultraviolet A (UVA)-irradiated hairy male Crj:CD-1 mice. The learning ability of 6- and 12-months UVA-irradiated mice was significantly reduced compared to un-irradiated age-matched mice. Acetylcholine levels, acetylcholinesterase and choline acetyltransferase activities in the whole brains were decreased in both of 6- and 12-month irradiated mice. Only 1 of 6 mice irradiated for 12 months was histologically observed to have a drastic loss of bilateral hippocampal pyramidal cells in the CA1 field of Ammon's horn.
Hiramoto
K
K
Biochemical Research Institute, Nippon Menard Cosmetic Co., Ltd, Gifu, Japan.
Okada
T
T
Ito
M
M
D000818:Animals; D001522:Behavior, Animal / Q000528:radiation effects*; D002799:Cholinergic Fibers / Q000528:radiation effects*; D006624:Hippocampus / Q000528:radiation effects; D007858:Learning / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D014466:Ultraviolet Rays