[Transgenic mice for analysis of neoplasm transformation processes of T and B lymphocytes].
This article describes the significance of the mouse transgenic model in elucidation of the role and the oncogenic potential of such genes as N-ras, pim-1, bcl-2, myc and p53. The role of gene targetting by homologous recombination in the study of preneoplastic state in the mice model was also discussed.
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Laboratorium Immunologii Komórkowej Instytutu Immunologii i Terapii Doświadczalnej im. L. Hirszfelda PAN we Wrocławiu.
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D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000276:immunology; D004195:Disease Models, Animal; D016153:Genes, Suppressor; D008213:Lymphocyte Activation / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D011230:Precancerous Conditions / Q000503:physiopathology*; D011519:Proto-Oncogenes / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*