Human syngeneic intestinal transplantation: evaluation of enterocyte viability with serum levels of intestinal fatty acid binding protein.
In a case of human syngeneic intestinal transplantation, the post-operative course was complicated by the Systemic Inflammatory Response System (SIRS). This syndrome was characterized by negative cultures and elevated levels of the pro-inflammatory cytokines, IL-1 beta, IL-6 and TNF. In keeping with current concepts of translocation across the enterocyte barrier as the etiology of SIRS, levels of intestinal fatty acid binding protein (I-FABP), an enterocyte-specific protein, also increased. These observations suggest that (i) a clinical syndrome consistent with translocation may occur in the absence of rejection in intestinal transplantation, and (ii) I-FABP may serve as a clinically relevant marker for enterocyte injury.
Kuo
P C
PC
Department of Surgery, Stanford University Medical Center, California, USA.
Morris
J
J
Marks
W H
WH
Lieberman
J M
JM
Johnson
D L
DL
Alfrey
E J
EJ
Bastidas
J A
JA
Dafoe
D C
DC
D000328:Adult; D015415:Biomarkers / Q000097:blood; D002352:Carrier Proteins / Q000097:blood*; D002432:Cecum / Q000637:transplantation*; D002470:Cell Survival; D016207:Cytokines / Q000097:blood; D004751:Enteritis / Q000175:diagnosis* / Q000209:etiology; D004847:Epithelial Cells; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D007082:Ileum / Q000637:transplantation*; D007422:Intestines / Q000166:cytology*; D008297:Male; D018996:Myelin P2 Protein / Q000097:blood*; D009363:Neoplasm Proteins; D011183:Postoperative Complications; D014185:Transplantation, Isogeneic; D025521:Tumor Suppressor Proteins
D015415:Biomarkers; D002352:Carrier Proteins; D016207:Cytokines; C107608:FABP7 protein, human; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D018996:Myelin P2 Protein; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins