Rat fibroblast growth factor receptor-4 mRNA in the brain is preferentially expressed in cholinergic neurons in the medial habenular nucleus.
We examined the cellular localization of fibroblast growth factor receptor (FGFR)-4 mRNA preferentially expressed in the medial habenular nucleus by in situ hybridization. FGFR-4 mRNA was expressed in the ventral part of the medial habenular nucleus. FGFR-4 mRNA was colocalized with choline acetyltransferase mRNA to a high degree (more than 90%), indicating that FGFR-4 mRNA-expressed cells are cholinergic neurons. The present finding indicates that FGFR-4 in the brain has a function specific to cholinergic neurons in the ventral part of the medial habenular nucleus.
Miyake
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A
Department of Genetic Biochemistry, Kyoto University Faculty of Pharmaceutical Sciences, Japan.
Itoh
N
N
D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D002795:Choline O-Acetyltransferase / Q000096:biosynthesis / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics; D051519:Fibroblast Growth Factor 4; D005346:Fibroblast Growth Factors / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics*; D009474:Neurons / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D051499:Receptor, Fibroblast Growth Factor, Type 4; D017468:Receptors, Fibroblast Growth Factor / Q000096:biosynthesis / Q000235:genetics*; D013787:Thalamic Nuclei / Q000166:cytology / Q000378:metabolism*
D018076:DNA, Complementary; C496447:Fgf4 protein, rat; D051519:Fibroblast Growth Factor 4; D009419:Nerve Tissue Proteins; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors; D002795:Choline O-Acetyltransferase; C496373:Fgfr4 protein, rat; D051499:Receptor, Fibroblast Growth Factor, Type 4; D000109:Acetylcholine