[An experimental study on antitumor effect of MMC-fibrin glue mixture].
In spite of postoperative chemo- and/or radiation therapy, the prognosis of advanced cancer patients undergoing palliative operation is still poor. Therefore, in order to improve the effect of chemotherapy, we made a mixture of MMC and fibrin glue (MMC-FIB) as a local chemotherapy. Using FIB with MMC, we expected to enhance the efficiency of MMC by sustained release of MMC. We examined cytotoxic effects and anti-tumor effects of the MMC-FIB using a gastric cancer cell line (MKN-28) and an esophageal cancer cell line (KE-3). Effects of the MMC-FIB were twice as strong as those of MMC on in vitro and in vivo studies. MMC-FIB is easy to make and apply to residual tumor. These results suggest that MMC-FIB is an effective treatment as a local chemotherapy for postoperative residual cancer.
Tanaka
T
T
First Dept. of Surgery, Kurume University School of Medicine.
Yamana
H
H
Fujita
H
H
Ono
T
T
Tou
Y
Y
Fujii
T
T
Uhi
T
T
Shirouzu
K
K
D000818:Animals; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage*; D051379:Mice; D008819:Mice, Nude; D016685:Mitomycin / Q000008:administration & dosage*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014407:Tumor Cells, Cultured
D015718:Fibrin Tissue Adhesive; D016685:Mitomycin