The role of sertraline in a patient with recurrent hyponatremia.
A 75-year-old female with major depression was admitted to the hospital on two separate occasions for medical problems. During both her hospitalizations she was evaluated by a psychiatrist and diagnosed with a major depressive episode. On both admissions the antidepressant chosen to treat her depression was sertraline. Each time the patient was treated with sertraline she developed significant hyponatremia within 7 days of the initiation of therapy. The case is presented and discussed, with special emphasis on the prior reports of hyponatremia associated with sertraline use, and the treatment alternatives.
Catalano
G
G
Department of Psychiatry and Behavioral Medicine, University of South Florida College of Medicine, Tampa, USA.
Kanfer
S N
SN
Catalano
M C
MC
Alberts
V A
VA
D015057:1-Naphthylamine / Q000009:adverse effects / Q000031:analogs & derivatives*; D000368:Aged; D000928:Antidepressive Agents / Q000009:adverse effects*; D003866:Depressive Disorder / Q000188:drug therapy; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced* / Q000378:metabolism / Q000628:therapy; D012008:Recurrence; D020280:Sertraline
D000928:Antidepressive Agents; D015057:1-Naphthylamine; D020280:Sertraline