title: HPLC and GLC determination of residual solvents in busulphan.
abstract: Quantitative methods using HPLC and GLC for the determination of residual pyridine and ethanol in busulphan have been developed. The measurement errors for pyridine and ethanol in busulphan samples (p = 0.95) were found to be 10% and 7%. It was shown that one recrystallization enabled pure busulphan to be prepared.
authors.affiliation: Institute of Organic Chemistry, Ukrainian Academy of Sciences, Kiev.
authors.forename: O I
authors.initials: OI
authors.lastname: Kalchenko
authors.forename: V A
authors.initials: VA
authors.lastname: Golub
authors.forename: I V
authors.initials: IV
authors.lastname: Zavatskaja
mesh_terms: D002066:Busulfan / Q000032:analysis*; D002138:Calibration; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D004340:Drug Contamination; D004350:Drug Residues / Q000032:analysis*; D000431:Ethanol / Q000032:analysis; D011725:Pyridines / Q000032:analysis; D012996:Solutions; D012997:Solvents / Q000032:analysis*
chemical_list: D011725:Pyridines; D012996:Solutions; D012997:Solvents; D000431:Ethanol; D002066:Busulfan