A gene for nonspecific X-linked mental retardation (MRX41) is located in the distal segment of Xq28.
We report on a family in which nonsyndromal mild to moderate mental retardation segregates as an X-linked trait (MRX41). Two point linkage analysis demonstrated linkage between the disorder and marker DXS3 in Xq21.33 with a lod score of 2.56 at theta = 0.0 and marker DXS1108 in Xq28 with a lod score of 3.82 at theta = 0.0. Multipoint linkage analysis showed that the odds for a location of the gene in Xq28 vs Xq21.33 are 100:1. This is the fourth family with non-specific X-linked mental retardation with Xq28-qter as the most likely gene localization.
Hamel
B C
BC
Department of Human Genetics, University Hospital, Nijmegen, The Netherlands.
Kremer
H
H
Wesby-van Swaay
E
E
van den Helm
B
B
Smits
A P
AP
Oostra
B A
BA
Ropers
H H
HH
Mariman
E C
EC
D002874:Chromosome Mapping; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D008126:Lod Score; D008297:Male; D010375:Pedigree; D014960:X Chromosome