[Biochemical mechanisms of protective action of enomelanin during hemic hypoxia caused by carbon monoxide].
Prophylactic injection of enomelanine has been studied for its effect on hemic hypoxia and on different parts of breathing system. The enomelanine was shown to be effective for decreasing the level of carboxyhemoglobin and for protection from succinate dehydrogenase and cytochromoxidase. The authors think that these effects of enomelanine are conditioned not only by its anti-hypoxia abilities, but also by the capacity to activate the alternative protective mechanisms of the cell.
Barinova
I E
IE
Galkin
B N
BN
Golovenko
N Ia
NIa
Osetrov
V E
VE
Savva
V M
VM
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001921:Brain / Q000201:enzymology; D002245:Carbon Dioxide; D002263:Carboxyhemoglobin / Q000096:biosynthesis*; D004579:Electron Transport / Q000187:drug effects; D003576:Electron Transport Complex IV / Q000187:drug effects; D000860:Hypoxia / Q000139:chemically induced / Q000517:prevention & control*; D008099:Liver / Q000201:enzymology; D008297:Male; D008543:Melanins / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013385:Succinate Dehydrogenase / Q000187:drug effects
D000975:Antioxidants; D008543:Melanins; C049066:enomelanin; D002245:Carbon Dioxide; D002263:Carboxyhemoglobin; D013385:Succinate Dehydrogenase; D003576:Electron Transport Complex IV