Acquired growth hormone resistance in catabolic states.
Catabolic patients are resistant to the actions of GH. This resistance is probably multifactorial in origin. It is likely that both the fasting state and circulating factors, possibly cytokines, are aetiological. Resistance or insensitivity is characterized by raised GH levels, low IGF-I levels and a reduced anabolic response to GH.
Jenkins
R C
RC
University of Sheffield, Clinical Sciences Centre, Northern General Hospital.
Ross
R J
RJ
D006130:Growth Disorders / Q000209:etiology*; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism / Q000503:physiopathology; D011502:Protein-Energy Malnutrition / Q000378:metabolism / Q000503:physiopathology; D018805:Sepsis / Q000378:metabolism / Q000503:physiopathology; D013997:Time Factors; D014947:Wounds and Injuries / Q000378:metabolism / Q000503:physiopathology
D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone