P50 changes with visual interference in normal subjects: a sensory distraction model for schizophrenia.
Twenty-five normal subjects were tested in a Conditioning-Testing (S1-S2) auditory P50 study. Each subject was tested twice under two experimental conditions: distraction condition (with light interference) and control condition (without interference). Results showed that S1 P50 amplitude was significantly decreased with visual interference compared with that in the control condition, while the S2 response remained unchanged. Consequently, the S2/S1 gating ratio was also increased remarkably in the distraction condition. The auditory EP changes with the visual distraction in normals closely resembled the abnormal findings in schizophrenic subjects. These data may provide an alternative model to elucidate the psychophysiological mechanism that possibly rules the changes of attention in schizophrenia.
Jin
Y
Y
Department of Psychiatry and Human Behavior, University of California Irvine Medical Center, Orange 92668, USA.
Potkin
S G
SG
D000161:Acoustic Stimulation; D000328:Adult; D001143:Arousal / Q000502:physiology*; D001288:Attention / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D010775:Photic Stimulation; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D012815:Signal Processing, Computer-Assisted