Pharmacokinetic profile of plasma tocopherol following intramuscular administration of acetylated alpha-tocopherol to sheep.
Five sheep, with a mean BW of 45 kg, were given a single i.m. injection (600 IU) of dl-alpha-tocopherol acetate. Plasma concentration of alpha-tocopherol was best fitted to a single-compartment model. Two successive absorption processes were selected. The individual pharmacokinetic parameters were absorption rate constant, Ka1 = 0.29 +/- 0.02/h; the second absorption rate constant, Ka2 = 0.03 +/- 0.002/h; elimination half-life = 42.40 +/- 1.70/h; mean residence time = 46 +/- 0.92 h; and area under the curve = 290 +/- 10.77 micrograms/h per ml. During the first absorption process, elimination half-life was 2.46 +/- 0.22 h, and the second elimination half-life was 21.20 +/- 1.72 h. The peak concentration of vitamin E plasma (4.78 +/- 0.23 micrograms/ml) was observed at 14.6 +/- 4.08 h after i.m. injection. The increase in vitamin E concentration occurred because of gradual hepatic hydrolysis of the absorbed acetylated tocopherol.
Hidiroglou
M
M
Agriculture and Agri-Food Canada, Centre for Food and Animal Research, Ottawa, ON, Canada.
D000107:Acetylation; D000818:Animals; D007273:Injections, Intramuscular; D008433:Mathematics; D012756:Sheep / Q000097:blood*; D014810:Vitamin E / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*
D014810:Vitamin E