title: Trisomy 7 in keratoacanthoma and squamous cell carcinoma detected by fluorescence in-situ hybridization.
abstract: Keratoacanthoma (KA) is generally considered to be a clinically and histologically distinct entity, but it often remains difficult to separate from well-differentiated squamous cell carcinoma (WDSCC). Recently, trisomy 7 has been identified in squamous cell carcinoma of the skin. In this study, we examined classical KA (n = 6), WDSCC (n = 7) and squamous cell carcinoma with KA-like features (SCC-KA) (n = 8) for trisomy 7 by fluorescence in-situ hybridization (FISH) to determine if this chromosomal abnormality is unique to squamous lesions diagnosed as WDSCC, or shared by both KA and SCC. In addition, the pertinent clinical-histopathologic findings were summarized. Trisomy 7 was identified in one KA, one SCC-KA and two WDSCC. This study demonstrates that there is a chromosomal abnormality shared by KA and SCC, providing further evidence that KA is most likely a form of SCC. Further studies are required to determine if trisomy 7 in these lesions is of prognostic significance.
authors.affiliation: Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City 52242, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Cheville
authors.forename: C
authors.initials: C
authors.lastname: Bromley
authors.forename: Z B
authors.initials: ZB
authors.lastname: Argenyi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology*; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007636:Keratoacanthoma / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*; D014314:Trisomy