title: [Blood patch therapy of the perilymphatic fistulas--an experimental study].
abstract: Blood patch is a therapeutic procedure that uses a perilymphatic fistula to repair an inner ear window rupture by filling the tympanic cavity with autologous blood. The experimental study was conducted in 13 guinea pigs. Autologous blood or commercially available fibrin glue was poured into the otic bulla after artificial rupture of the round window. The animals were sacrificed immediately, or 1 to 7 days after the operation. The results showed that the blood or the fibrin glue successfully closed the window rupture by closing directly and by facilitating the formation of granulation at the margin of the rupture. Fibrin glue seemed to be preferable to autologous blood due to its non-toxic nature in the inner ear.
authors.affiliation: Department of Otorhinolaryngology, Ehime University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Shinohara
authors.forename: K
authors.initials: K
authors.lastname: Gyo
authors.forename: S
authors.initials: S
authors.lastname: Murakami
authors.forename: N
authors.initials: N
authors.lastname: Yanagihara
mesh_terms: D000818:Animals; D001769:Blood; D004432:Ear, Middle; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use; D005402:Fistula / Q000628:therapy*; D006168:Guinea Pigs; D007759:Labyrinth Diseases / Q000628:therapy*; D008722:Methods; D012405:Round Window, Ear / Q000293:injuries; D012421:Rupture
chemical_list: D015718:Fibrin Tissue Adhesive