Efficacy of clarithromycin versus that of clindamycin for single-dose prophylaxis of experimental streptococcal endocarditis.
Clarithromycin is compared with clindamycin for single-dose prophylaxis of streptococcal endocarditis in rats. Human-like kinetics of the two antibiotics prevented endocarditis in animals challenged with both small and large amounts of bacterial inocula. Clarithromycin was marginally superior to clindamycin against small amounts of inocula. Clarithromycin may be considered for endocarditis chemoprophylaxis in human.
Vermot
D
D
Department of Internal Medecine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Entenza
J M
JM
Vouillamoz
J
J
Glauser
M P
MP
Moreillon
P
P
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017291:Clarithromycin / Q000627:therapeutic use*; D002981:Clindamycin / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D004697:Endocarditis, Bacterial / Q000382:microbiology / Q000517:prevention & control*; D004917:Erythromycin / Q000627:therapeutic use; D051381:Rats; D015610:Serum Bactericidal Test; D013290:Streptococcal Infections / Q000382:microbiology / Q000517:prevention & control*
D000900:Anti-Bacterial Agents; D002981:Clindamycin; D004917:Erythromycin; D017291:Clarithromycin