title: [Myelodysplastic syndrome with CREST syndrome successfully treated with metenolone--A case report].
abstract: A 54-year-old woman was diagnosed as having refractory anemia (RA) with CREST syndrome (incomplete type). She showed Raynaud's phenomenon, sclerodactyly and telangiectasia, but not calcinosis and esophageal dysmotility. Laboratory findings revealed anemia and thrombocytopenia, and myelodysplasia, abnormal karyotype of 47, XX, +8 in bone marrow cells. Antinuclear and centromere antibody was positive. Treatment with prednisolone was not successful. After prednisolone was tapered, she was given 20 mg/body metenolone orally, which led to hematological improvement, and after 6 months of therapy, abnormal karyotype of 47, XX, +8 disappeared.
authors.affiliation: Third Department of Internal Medicine, Japanese Red Cross Society Wakayama Medical Center, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hamamoto
authors.forename: T
authors.initials: T
authors.lastname: Ohno
authors.forename: H
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D045930:Anabolic Agents / Q000627:therapeutic use*; D017675:CREST Syndrome / Q000150:complications / Q000188:drug therapy*; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007621:Karyotyping; D008710:Methenolone / Q000627:therapeutic use*; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000188:drug therapy* / Q000235:genetics; D014314:Trisomy
chemical_list: D045930:Anabolic Agents; D008710:Methenolone