title: Allele doses of apolipoprotein E type epsilon 4 in sporadic late-onset Alzheimer's disease.
abstract: Apoliprotein E, type epsilon 4 allele (ApoE-epsilon 4) is associated with late-onset sporadic Alzheimer's disease (AD). We have found that the cumulative probability of remaining unaffected over time decreases for each dose of ApoE-epsilon 4 in sporadic, late-onset French AD. The effect of genotypes on age at onset of AD was analyzed using the product limit method, to compare unaffected groups during aging.
authors.affiliation: Régional Center of Neurogenetics, CHR of Reims, France.
authors.forename: G
authors.initials: G
authors.lastname: Lucotte
authors.forename: A
authors.initials: A
authors.lastname: Aouizérate
authors.forename: N
authors.initials: N
authors.lastname: Gérard
authors.forename: J C
authors.initials: JC
authors.lastname: Turpin
authors.forename: P
authors.initials: P
authors.lastname: Landais
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D018628:Gene Dosage; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012737:Sex Factors
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E