title: Clinical utility of clozapine in 16 patients with neurological disease.
abstract: Patients who develop psychosis or agitated behavior secondary to neurological disorders present a therapeutic dilemma. The authors review clinical efficacy and side effect profiles of clozapine in a cohort of 16 patients with various neurobehavioral disorders. One-third showed a marked decrease in symptoms while on clozapine. However, one-quarter developed an acute confusional state; of these, all had diffuse slowing on their baseline EEG prior to starting the drug.
authors.affiliation: Department of Psychiatry, Medical College of Pennsylvania, Pittsburgh, PA 15212, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Duffy
authors.forename: R
authors.initials: R
authors.lastname: Kant
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003024:Clozapine / Q000009:adverse effects / Q000627:therapeutic use*; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000150:complications / Q000188:drug therapy*; D011618:Psychotic Disorders / Q000209:etiology* / Q000523:psychology; D012189:Retrospective Studies
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine