Perspectives and molecular diagnosis of Duchenne and Becker muscular dystrophies.
Molecular genetic understanding of Duchenne and Becker muscular dystrophies has unfolded rapidly in the past decade. The new molecular understanding has enhanced diagnosis, prognosis, carrier detection, and prenatal diagnosis. Most importantly, strategies are being devised currently for the treatment of the disorder. This article provides an update on the molecular findings and their applicability in clinical practice.
Prior
T W
TW
Department of Pathology, Ohio State University, Columbus 43210, USA.
D001706:Biopsy; D015139:Blotting, Southern; D015153:Blotting, Western; D017690:Cell Transplantation; D004247:DNA / Q000302:isolation & purification; D004252:DNA Mutational Analysis / Q000379:methods*; D017353:Gene Deletion; D018014:Gene Transfer Techniques; D006580:Genetic Carrier Screening; D015316:Genetic Therapy; D006801:Humans; D008967:Molecular Biology; D005810:Multigene Family / Q000235:genetics; D018482:Muscle, Skeletal / Q000166:cytology / Q000637:transplantation; D009132:Muscles / Q000737:chemistry; D009136:Muscular Dystrophies / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy
D004247:DNA