title: Itraconazole in the treatment of orbital aspergillosis.
abstract: BACKGROUND
  Sino-orbital aspergillosis is typically treated with surgical debridement and intravenous amphotericin B. Some authors have advocated intraorbital irrigation or injection of amphotericin B in specific cases.
  
  
  METHODS
  An immunocompetent patient with recurrent sino-orbital aspergillosis is presented. After failing two attempts at traditional therapeutic modalities, treatment with oral itraconazole was initiated.
  
  
  RESULTS
  The patient has had resolution of her sino-orbital disease without recurrence at 10 months of follow-up.
  
  
  CONCLUSIONS
  In immunocompetent patients with orbital aspergillosis, itraconazole should be considered as a treatment option in patients who have recurrent or recalcitrant disease, or in those who cannot tolerate amphotericin B.
authors.affiliation: Department of Ophthalmology, St. Louis University School of Medicine, Anheuser-Busch Eye Institute, USA.
authors.forename: G G
authors.initials: GG
authors.lastname: Massry
authors.forename: A
authors.initials: A
authors.lastname: Hornblass
authors.forename: W
authors.initials: W
authors.lastname: Harrison
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000473:pathology; D001232:Aspergillus fumigatus / Q000302:isolation & purification; D015821:Eye Infections, Fungal / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D017964:Itraconazole / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D009915:Orbit / Q000382:microbiology; D009916:Orbital Diseases / Q000188:drug therapy* / Q000382:microbiology* / Q000473:pathology; D012008:Recurrence
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole