Evaluation of certain ureas and nitrosoureas of 2,3-dihydro-1,4-benzothiazines against Sarcoma-180 solid tumors in vivo.
Different derivatives of nitrosoureas were synthesized by a long sequence of reactions and were evaluated for their anticancer activities against female Swiss albino mice, 6-8 weeks old, weighing 18-24 g and bearing Sarcoma-180 (S-180) ascitic tumor. Experimental protocols include injecting a total of 2 x 10(5) S-180 viable ascitic cells s.c. on day 0 in the left flank of mice to obtain solid tumors, followed by the treatment of urea/nitrosourea derivatives on days 1, 5 and 9 at different dose levels. Of the 32 compounds tested, eight were found highly active against solid tumors with significant growth delay and tumor weight inhibition ratio. 5-Fluorouracil was injected s.c. as referent compound to positive control animals.
Nyati
M K
MK
Department of Zoology, University of Rajasthan, Jaipur, India.
Rajoria
C M
CM
Gupta
R R
RR
Dev
P K
PK
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D051379:Mice; D012510:Sarcoma 180 / Q000188:drug therapy*; D013843:Thiazines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use*; D014508:Urea / Q000031:analogs & derivatives* / Q000737:chemistry
D000970:Antineoplastic Agents; D013843:Thiazines; C097624:2,3-dihydro-1,4-benzothiazine; D014508:Urea