title: Onset time of topical analgesia with EMLA 5%: no reduction with glyceryl trinitrate.
abstract: Many adults are distressed by painful investigations or treatment, including venepuncture. The early effects of Eutectic Mixture of Local Anaesthetics (EMLA) 5%, on relief of pinprick pain in the antecubital area was investigated and compared with EMLA plus glyceryl trinitrate and with a placebo cream in 100 patients. Topical analgesia after application of EMLA developed within 5 min in 69% and within 10 min in 83% of those tested, significantly different from placebo, (P = 0.01).
authors.affiliation: Royal West Sussex Hospital, Chichester, United Kingdom.
authors.forename: M R
authors.initials: MR
authors.lastname: Nott
authors.forename: C J
authors.initials: CJ
authors.lastname: Clemson
authors.forename: J L
authors.initials: JL
authors.lastname: Peacock
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000698:Analgesia; D000779:Anesthetics, Local / Q000494:pharmacology*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000494:pharmacology*; D000077442:Lidocaine, Prilocaine Drug Combination; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000494:pharmacology*; D011318:Prilocaine / Q000494:pharmacology*; D013997:Time Factors; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D000779:Anesthetics, Local; D004338:Drug Combinations; D000077442:Lidocaine, Prilocaine Drug Combination; D014665:Vasodilator Agents; D011318:Prilocaine; D008012:Lidocaine; D005996:Nitroglycerin