title: [Metamphocin in the treatment of ocular mycoses].
abstract: Metamphocin (methyl ether of amphotericin B), a new antifungal polyene antibiotic was used in the treatment of ocular mycoses. The procedure and results of its use are described. The clinical trials included 8 patients with keratomycosis and 2 patients with fungal endophthalmitis. Metamphocin was administered as drop-like intravenous injections in combination with local instillation of ketoconazole and dexamethasol. The clinical trials showed that metamphocin was an efficient antifungal drug useful in the treatment of ocular mycoses. Metamphocin proved to be less toxic than amphotericin B.
authors.forename: Iu F
authors.initials: IuF
authors.lastname: Maĭchuk
authors.forename: U V
authors.initials: UV
authors.lastname: Diadina
mesh_terms: D000666:Amphotericin B / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D003316:Corneal Diseases / Q000188:drug therapy; D003907:Dexamethasone / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D009877:Endophthalmitis / Q000188:drug therapy; D015821:Eye Infections, Fungal / Q000188:drug therapy*; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; C017501:methylamphotericin B; D003907:Dexamethasone; D000666:Amphotericin B; D007654:Ketoconazole