title: The successful treatment of a gender dysphoric patient with pimozide.
abstract: OBJECTIVE
  The case is reported of a gender dysphoric patient who responded successfully to pharmacotherapy with pimozide.
  
  
  METHODS
  An adult male patient with a borderline learning disability presented with cross-dressing and a strong wish to undergo a sex change.
  
  
  METHODS
  Supportive psychotherapy and pharmacotherapy with pimozide was tried.
  
  
  RESULTS
  There was an excellent response to pimozide 2 mg daily, with a cessation of both cross-dressing and the wish for sex reassignment. When, after 1 year, the dose was reduced to 1 mg daily, there was a rapid return of the cross-dressing and the wish for sex reassignment. An increase in the dose again led to a remission which has been maintained since then.
  
  
  CONCLUSIONS
  Pharmacotherapy with pimozide should be considered in cases of doubtful gender dysphoria.
authors.affiliation: Department of Psychiatry, Charing Cross and Westminster Medical School, University of London, UK.
authors.forename: B K
authors.initials: BK
authors.lastname: Puri
authors.forename: I
authors.initials: I
authors.lastname: Singh
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005783:Gender Identity; D006801:Humans; D008297:Male; D010868:Pimozide / Q000008:administration & dosage* / Q000009:adverse effects; D014189:Transsexualism / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology
chemical_list: D014150:Antipsychotic Agents; D010868:Pimozide