title: Measurement of myocardial accumulation of 123I-metaiodobenzylguanidine for studying cardiac autonomic neuropathy in diabetes mellitus.
abstract: The association of myocardial 123I-metaiodobenzylguanidine (MIBG) accumulation and autonomic neuropathy, as well as factors known to affect autonomic nervous function, were studied in a group of 12 diabetic patients representing different degrees of autonomic failure. The early myocardial uptake phase of 123I-MIBG was measured by calculating the peak net influx rate for the first 30 min after the 123I-MIBG injection and by single photon emission computed tomography (SPECT) imaging 1 h after the injection. The retainment of 123I-MIBG in the myocardium was measured using SPECT imaging 6 h after the injection, and myocardial uptake and the myocardium/liver uptake ratio were calculated. The 6-h myocardium/liver uptake ratio of 123I-MIBG was significantly (p < 0.05) lower in the diabetic patients with clinically evident autonomic neuropathy compared with those without autonomic neuropathy. Greater body mass index was associated with lower peak net influx rate and 1-h myocardial uptake of 123I-MIBG, and greater diastolic blood pressure was associated with lower 1-h myocardial uptake of 123I-MIBG, whether or not the patients had diabetic autonomic neuropathy. In conclusion, reduction in the 6-h myocardium/liver uptake ratio of 123I-MIBG is related to diabetic autonomic neuropathy. Because the early 123I-MIBG accumulation in myocardium is reduced in diabetic patients with greater body mass index and diastolic blood pressure, irrespective of autonomic neuropathy, our results encourage the use of the late myocardial accumulation of 123I-MIBG for studying sympathetic neuropathy in the diabetic heart.
authors.affiliation: Research Institute of Military Medicine, Helsinki, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Mäntysaari
authors.forename: J
authors.initials: J
authors.lastname: Kuikka
authors.forename: J
authors.initials: J
authors.lastname: Mustonen
authors.forename: K
authors.initials: K
authors.lastname: Tahvanainen
authors.forename: E
authors.initials: E
authors.lastname: Vanninen
authors.forename: E
authors.initials: E
authors.lastname: Länsimies
authors.forename: M
authors.initials: M
authors.lastname: Uusitupa
mesh_terms: D019797:3-Iodobenzylguanidine; D000328:Adult; D000368:Aged; D001342:Autonomic Nervous System Diseases / Q000378:metabolism*; D016022:Case-Control Studies; D003929:Diabetic Neuropathies / Q000378:metabolism*; D005080:Exercise Test; D006321:Heart / Q000294:innervation; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D011869:Radioligand Assay; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine