title: Electron transfer from cytochrome b5 to cytochrome c.
abstract: The reaction of cytochrome b5 with cytochrome c has become a very prominent system for investigating fundamental questions regarding interprotein electron transfer. One of the first computer modeling studies of electron transfer and protein/protein interaction was reported using this system. Subsequently, numerous studies focused on the experimental determination of the features which control protein/protein interactions. Kinetic measurements of the intracomplex electron transfer reaction have only appeared in the last 10 years. The current review will provide a summary of the kinetic measurements and a critical assessment of the interpretation of these experiments.
authors.affiliation: Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville 72701, USA.
authors.forename: B
authors.initials: B
authors.lastname: Durham
authors.forename: J L
authors.initials: JL
authors.lastname: Fairris
authors.forename: M
authors.initials: M
authors.lastname: McLean
authors.forename: F
authors.initials: F
authors.lastname: Millett
authors.forename: J R
authors.initials: JR
authors.lastname: Scott
authors.forename: S G
authors.initials: SG
authors.lastname: Sligar
authors.forename: A
authors.initials: A
authors.lastname: Willie
mesh_terms: D000595:Amino Acid Sequence; D001665:Binding Sites; D003198:Computer Simulation; D003574:Cytochrome c Group / Q000737:chemistry* / Q000378:metabolism*; D015786:Cytochromes b5 / Q000737:chemistry* / Q000378:metabolism*; D004579:Electron Transport; D007700:Kinetics; D008958:Models, Molecular; D017433:Protein Structure, Secondary; D013816:Thermodynamics
chemical_list: D003574:Cytochrome c Group; D015786:Cytochromes b5