Analysis of serological surveys using mixture models: application to a survey of parvovirus B19.
A method for the analysis of age stratified antibody prevalence surveys is developed. The age specific distribution of the quantitative results of serological antibody tests is modelled as a mixture of seropositive and seronegative components. This yields maximum likelihood estimates of the prevalence at each age. The method is illustrated using data from a previously reported survey of antibody to parvovirus B19.
Gay
N J
NJ
Immunisation Division, PHLS Communicable Disease Surveillance Centre, London, U.K.
D000293:Adolescent; D017677:Age Distribution; D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D016001:Confidence Intervals; D004797:Enzyme-Linked Immunosorbent Assay; D006306:Health Surveys; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016013:Likelihood Functions; D015233:Models, Statistical; D016732:Parvovirus B19, Human / Q000276:immunology / Q000302:isolation & purification*; D015995:Prevalence; D012698:Serologic Tests / Q000706:statistics & numerical data*
D000914:Antibodies, Viral