[Cholecystokinin-B/gastrin receptor is a novel molecular probe for human small cell lung cancer].
Cloning of CCK-B/gastrin receptor cDNAs showed that they possess the feature of serpentine G protein coupled receptors. In this study, the receptor mRNA was detected selectively in all SCLCs (10 cases) with a RT-PCR assay. By contrast, it was detectable in only one of thirteen squamous cell carcinomas or twenty-one adenocarcinomas of lung. Thus, CCK-B/gastrin receptor has been demonstrated to provide a novel molecular marker for the diagnosis of small cell lung cancer (SCLC) by using biopsy specimens.
Matsumori
Y
Y
Department of Medicine, Kobe University School of Medicine.
Katakami
N
N
Iwata
N
N
Matsui
T
T
D014408:Biomarkers, Tumor / Q000235:genetics*; D018288:Carcinoma, Small Cell / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D011949:Receptors, Cholecystokinin / Q000235:genetics*
D014408:Biomarkers, Tumor; D011949:Receptors, Cholecystokinin