title: Obstetric complications and autoantibodies in schizophrenia.
abstract: Our hypothesis stated that patients with schizophrenia who had obstetric complications (OC) were more likely to have autoimmune abnormalities than those without OC. OC were rated using a checklist. Anti-brain autoantibodies were measured in serum using an enzyme immunoassay. Autoantibodies to non-CNS tissues were detected using serological procedures. There were no significant differences between the groups with respect to anti-brain antibodies, but patients with OC (n = 24) had a significantly higher prevalence of autoantibodies to non-CNS tissues than patients without OC (n = 25). Both groups were receiving neuroleptic drugs. OC may contribute to autoimmune abnormalities among patients with schizophrenia.
authors.affiliation: Department of Psychiatry (Immunopsychiatry Program), Western Psychiatric Institute & Clinic, Pittsburgh, PA 15213-2593, USA.
authors.forename: K N
authors.initials: KN
authors.lastname: Chengappa
authors.forename: V L
authors.initials: VL
authors.lastname: Nimgaonkar
authors.forename: C
authors.initials: C
authors.lastname: Bachert
authors.forename: Z W
authors.initials: ZW
authors.lastname: Yang
authors.forename: B S
authors.initials: BS
authors.lastname: Rabin
authors.forename: R
authors.initials: R
authors.lastname: Ganguli
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology*; D001930:Brain Injuries / Q000150:complications / Q000209:etiology* / Q000276:immunology*; D002746:Chlorpromazine / Q000627:therapeutic use; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D007744:Obstetric Labor Complications; D011247:Pregnancy; D012559:Schizophrenia / Q000188:drug therapy / Q000209:etiology / Q000276:immunology*
chemical_list: D014150:Antipsychotic Agents; D001323:Autoantibodies; D002746:Chlorpromazine