title: Activation of pulmonary rapidly adapting receptors does not induce bronchoconstriction in dogs.
abstract: Activation of pulmonary rapidly adapting receptors (RARs) is believed to constrict airways by a vagally mediated reflex. We tested this hypothesis in dogs anesthetized with sufentanil citrate. We ventilated both lungs separately at a positive end-expiratory pressure of 4 cmH2O. We stimulated RARs in one lung under three different conditions: 1) deflation of the lung; 2) decrease in lung compliance; and 3) aerosolization of methacholine. We monitored the airway pressure in the nonstimulated lung as an index for airway muscle tone and could not detect increases in the pressure swing under these conditions. On the other hand, electrical stimulation of the distal end of cervical vagus nerve increased the pressure swing bilaterally (ipsilateral dominant), suggesting that reflex response could be detected in our preparation. Moreover, deflation (or inflation) of either lung increased (or suppressed) diaphragmatic activity. The results indicate intact vagal afferents and central response in our preparation. We conclude that activation of RARs located below the carina does not induce bronchoconstriction by a centrally mediated reflex. If any effect is present, it appears to be small.
authors.affiliation: Section of Respiratory Diseases, University of Manitoba, Winnipeg, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Yu
authors.forename: S
authors.initials: S
authors.lastname: Mink
mesh_terms: D000336:Aerosols; D000399:Air Pressure; D000403:Airway Resistance / Q000187:drug effects / Q000502:physiology; D000818:Animals; D016084:Bronchoconstriction / Q000187:drug effects / Q000502:physiology*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000494:pharmacology; D003964:Diaphragm / Q000502:physiology; D004285:Dogs; D004558:Electric Stimulation; D004576:Electromyography; D005246:Feedback / Q000502:physiology; D005260:Female; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology; D008170:Lung Compliance / Q000187:drug effects / Q000502:physiology; D008297:Male; D016210:Methacholine Chloride / Q000008:administration & dosage / Q000494:pharmacology; D009476:Neurons, Efferent / Q000502:physiology; D011175:Positive-Pressure Respiration; D011661:Pulmonary Stretch Receptors / Q000187:drug effects / Q000502:physiology*; D012026:Reflex, Stretch / Q000187:drug effects / Q000502:physiology; D014630:Vagus Nerve / Q000166:cytology / Q000502:physiology
chemical_list: D000336:Aerosols; D001993:Bronchodilator Agents; D016210:Methacholine Chloride; D006632:Histamine