title: The comparative safety and diagnostic accuracy of adenosine myocardial perfusion imaging in women versus men.
abstract: OBJECTIVE
  To determine if the diagnostic accuracy and safety of intravenous adenosine myocardial perfusion imaging is significantly different in men compared with women.
  
  
  METHODS
  Prospective, comparative, open-label clinical trial.
  
  
  METHODS
  Nuclear medicine laboratory in a university-affiliated hospital.
  
  
  METHODS
  Consecutive patients who were referred for evaluation of known or suspected coronary artery disease. Patients were judged not to be able to exercise adequately.
  
  
  METHODS
  Coronary angiography was conducted within 6 weeks of an adenosine thallium-201 myocardial perfusion imaging study.
  
  
  RESULTS
  Diagnostic accuracy is shown in the table. [table: see text] Overall, side effects from adenosine were not different between men and women. The frequencies of ST depression and chest pain were significantly greater in women than men, although their etiologies are unknown. The frequency of severe side effects such as heart block and hypotension was not different between men and women.
  
  
  CONCLUSIONS
  The diagnostic accuracy and safety of adenosine thallium-201 myocardial perfusion imaging are generally similar in women and men.
authors.affiliation: School of Medicine, Creighton University, Omaha, Nebraska, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Mohiuddin
authors.forename: C K
authors.initials: CK
authors.lastname: Ravage
authors.forename: D J
authors.initials: DJ
authors.lastname: Esterbrooks
authors.forename: B D
authors.initials: BD
authors.lastname: Lucas
authors.forename: D E
authors.initials: DE
authors.lastname: Hilleman
mesh_terms: D000241:Adenosine / Q000008:administration & dosage / Q000009:adverse effects; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000187:drug effects; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D004311:Double-Blind Method; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012737:Sex Factors; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D013794:Thallium Radioisotopes; D000241:Adenosine