title: Primary signet-ring cell carcinoma of the urinary bladder.
abstract: Signet-ring cell carcinoma of the urinary bladder is a rare tumour, accounting for approximately 0.24% of all bladder malignancies. In this study, the clinicopathological findings in 13 cases are described. This malignancy is far more common in men than in women (ratio 11:2). The distribution by age and clinical symptoms can not distinguish it from transitional cell carcinoma. The tumour behaves like other high grade malignancies, presenting frequently at an advanced stage, and having an unfavourable clinical outcome. No special therapy seems superior to another.
authors.affiliation: Department of Pathology, Free University Hospital, Amsterdam.
authors.forename: R
authors.initials: R
authors.lastname: Torenbeek
authors.forename: R A
authors.initials: RA
authors.lastname: Koot
authors.forename: C E
authors.initials: CE
authors.lastname: Blomjous
authors.forename: P C
authors.initials: PC
authors.lastname: De Bruin
authors.forename: D W
authors.initials: DW
authors.lastname: Newling
authors.forename: C J
authors.initials: CJ
authors.lastname: Meijer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000473:pathology; D018279:Carcinoma, Signet Ring Cell / Q000473:pathology*; D018288:Carcinoma, Small Cell / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008679:Metaplasia / Q000473:pathology; D008875:Middle Aged; D012189:Retrospective Studies; D001749:Urinary Bladder Neoplasms / Q000473:pathology*