Effects of lactate on cross-spectral analysis of heart rate, blood pressure, and lung volume in normal volunteers.
Baroreceptor reflex sensitivity, coherence functions, and transfer functions between respiration and heart rate, and between respiration and blood pressure, were studied in nine normal volunteers before and after intravenous sodium lactate infusions. Cross-spectral analysis was used to examine heart rate, finger blood pressure, and respiration obtained with the subjects in a supine posture during spontaneous breathing. Sodium lactate produced a significant decrease of the modulus between respiration and heart rate (beats/min/l). There was no such change for the placebo infusions. The absence of a significant difference in the modulus between systolic blood pressure and heart rate for placebo or lactate indicated that there were no significant changes in the baroreceptor sensitivity index. These findings suggest that lactate infusions are associated with a decrease in cardiac vagal function.
Yeragani
V K
VK
Wright State University School of Medicine and Dayton VA Medical Center, OH 45428, USA.
Srinivasan
K
K
Balon
R
R
Berchou
R
R
D000328:Adult; D017704:Baroreflex / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D019344:Lactic Acid / Q000494:pharmacology*; D010919:Placebos; D012119:Respiration / Q000187:drug effects; D014109:Total Lung Capacity / Q000187:drug effects*
D010919:Placebos; D019344:Lactic Acid