Apolipoprotein E polymorphism, Alzheimer's disease and vascular dementia among elderly Finnish men.
An association between late-onset Alzheimer's disease, vascular dementia and the common polymorphic alleles of the gene coding for apolipoprotein E, epsilon 2, epsilon 3, and epsilon 4, was assessed in a population sample of 393 elderly Finnish men aged 70 to 89 years. Of them, 7% suffered Alzheimer's disease and 3% had vascular dementia. Among those who suffered Alzheimer's disease, there was a statistically significant excess of the epsilon 4 allele. No such an association was observed between the apolipoprotein E alleles and vascular dementia. We conclude that the apolipoprotein E polymorphism confers information about a risk of Alzheimer's disease in this population sample of elderly Finnish men.
Stengård
J H
JH
National Public Health Institute, Helsinki, Finland.
Pekkanen
J
J
Sulkava
R
R
Ehnholm
C
C
Erkinjuntti
T
T
Nissinen
A
A
D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D015140:Dementia, Vascular / Q000235:genetics*; D005387:Finland; D006801:Humans; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*
D001057:Apolipoproteins E