Cyclosporine nephrotoxicity and rejection crisis: diagnosis by urinary enzyme excretion.
The urinary enzymes alanine aminopeptidase (AAP; EC 3.4.11.2) and N-acetyl-B-D-glucosaminidase (NAG; EC 3.2.1.30) were measured daily in 35 renal transplant recipients during the early postoperative period. Each peak value of fractional excretion was corrected for its baseline value (CFE). CFE values above normal for both NAG and AAP were more frequently found in episodes of acute rejection than in cyclosporine acute nephrotoxicity episodes (76 vs. 0%; p < 0.001). Consequently, a rise in CFE levels for both NAG and AAP is strongly suggestive of acute rejection crisis.
Bornstein
B
B
Department of Biochemistry and Nephrology, Hospital 12 de Octubre, Madrid, Spain.
Arenas
J
J
Morales
J M
JM
Praga
M
M
Rodicio
J L
JL
Martinez
A
A
Valdivieso
L
L
D000118:Acetylglucosaminidase / Q000652:urine*; D000328:Adult; D018826:CD13 Antigens / Q000652:urine*; D016572:Cyclosporine / Q000633:toxicity*; D003937:Diagnosis, Differential; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis* / Q000188:drug therapy / Q000201:enzymology; D006801:Humans; D007166:Immunosuppressive Agents / Q000633:toxicity*; D007674:Kidney Diseases / Q000139:chemically induced; D016030:Kidney Transplantation / Q000276:immunology; D008297:Male; D008875:Middle Aged
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D000118:Acetylglucosaminidase; D018826:CD13 Antigens