Effect of ganglioside (GM1) on memory in senescent rats.
Monosialoganglioside GM1 (GM1) has been found to alleviate genetic and lesion-induced memory deficits. The purpose of this study was to investigate the effects of 7-day treatment with GM1 (50 mg/kg IP) on acquisition and retention performance of senescent rats in a passive avoidance situation. Saline-treated old rats showed a decreased performance in acquisition and retention tests as compared to saline-treated adult rats. GM1 improved both acquisition and retention performance of old animals, and there was no significant difference between GM1-treated old rats and saline-treated adult rats. These data suggest that GM1 treatment can improve memory deficits in intact senescent animals.
Silva
R H
RH
Departamento de Farmacologia, Escola Paulista de Medicina, São Paulo, Brasil.
Felicio
L F
LF
Nasello
A G
AG
Vital
M A
MA
Frussa-Filho
R
R
D000375:Aging / Q000187:drug effects*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D005732:Gangliosides / Q000494:pharmacology*; D008124:Locomotion / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D005732:Gangliosides