Antibodies to GM1 and Gal(beta 1-3)GalNAc at the nodes of Ranvier in human and experimental autoimmune neuropathy.
Autoantibodies to Gal(beta 1-3)GalNAc epitopes on glycolipids and glycoproteins are associated with motor neuron disease and motor or sensorimotor neuropathy. These epitopes are ubiquitously distributed on cell surfaces. In the nervous system they are present on axons and myelin, specifically also at the nodes of Ranvier. Binding of GM1 antibodies to the nodal area may contribute to disease development in some of these conditions.
Thomas
F P
FP
Department of Neurology, St. Louis University, Missouri 63110-2592, USA.
D000818:Animals; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis / Q000276:immunology* / Q000502:physiology; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000276:immunology*; D005677:G(M1) Ganglioside / Q000276:immunology*; D006801:Humans; D016472:Motor Neuron Disease / Q000276:immunology*; D011901:Ranvier's Nodes / Q000276:immunology*
D015295:Antigens, Tumor-Associated, Carbohydrate; D001323:Autoantibodies; C016467:Thomsen-Friedenreich antigen; D005677:G(M1) Ganglioside