Nonsteroidal antiinflammatory drug use and cognitive function in the elderly: inconclusive results from a population-based cohort study.
As part of the cohort Paquid, we studied the relationship between the use of NSAID, incidence of dementia, and evolution of cognitive functions. Dementia was diagnosed by DSM-III criteria and cognitive functions was assessed through the Mini-Mental Status Examination (MMSE). During 2 years of follow-up, the incidence rate of dementia was 3.84% among 53 NSAID users as compared with 3.77% in 1199 nonusers (OR, 0.98; 95% CI, 0.23-4.16). Using a cutoff of -3 points for the MMSE score and taking into account age and educational status in a logistic regression model, NSAID use was related to an unfavourable variation of the MMSE score (OR, 2.84; 95% CI, 0.99-8.1).
Fourrier
A
A
Arme-Pharmacovigilance, Centre de Pharmacovigilance, Hôpital Pellegrin, Bordeaux, France.
Letenneur
L
L
Bégaud
B
B
Dartigues
J F
JF
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D003072:Cognition Disorders / Q000453:epidemiology*; D015331:Cohort Studies; D003704:Dementia / Q000453:epidemiology; D006801:Humans; D007361:Intelligence Tests; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal