[Clinical significance of plasma free and conjugated dopamine and urinary excretion of free and conjugated dopamine in patients with renal transplantation].
Although free and conjugated dopamine (DA) constitutes most of plasma and urine catecholamine pool, the diagnostic significance of DA estimation for the evaluation of illness is not clear. Plasma free DA is mainly derived from the peripheral sympathetic nerve terminals and the released DA is converted to conjugated DA and to DA metabolites. The free DA concentration in plasma is trace in amount. Urinary free DA is mainly derived from renal tubular cells, and urinary conjugated DA is derived from filtrated DA at glomerulus. We investigated clinical significance of plasma free and conjugated DA and urinary excretion of free and conjugated DA in patients with chronic renal failure before and after renal transplantation. Marked elevation of plasma conjugated DA in patients with renal failure disappeared after hemodialysis or transplantation, like clinical picture of creatinine and blood urea nitrogen. Increases of urinary excretion of free and conjugated DA and of urinary volume were augmented in these patients after renal transplantation. The augmented excretion of urinary free DA resulted from the transplanted renal tubules, which indicate the functional fixation of transplanted kidneys into host patients. These results suggest that the estimations of plasma conjugated DA and urinary excretion of free DA are an important index for the evaluation of renal transplantation and renal function.
Komori
T
T
Clinical Laboratory Unit of University Hospital, Kyoto Prefectural University of Medicine.
Yoshimura
M
M
Yasumura
T
T
Suzuki
K
K
Morimoto
T
T
D000328:Adult; D004298:Dopamine / Q000097:blood* / Q000652:urine; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D011237:Predictive Value of Tests
D004298:Dopamine