title: Fluconazole infused via a nephrostomy tube: a novel and effective route of delivery.
abstract: Fluconazole is an effective oral or intravenous anti-fungal agent. It undergoes little or no metabolism with 70-80% of the drug excreted unchanged in the urine. There is no readily available information on its effectiveness in treating fungal urinary tract infections in the presence of chronic renal failure. We report a case of chronic renal failure with ureteric obstruction complicated by infection with Candida albicans that was successfully treated by the infusion of fluconazole via a nephrostomy tube. There were no complications related to the use of fluconazole.
authors.affiliation: Department of Nephrology, Dunedin Hospital, New Zealand.
authors.forename: S E
authors.initials: SE
authors.lastname: Oliver
authors.forename: R J
authors.initials: RJ
authors.lastname: Walker
authors.forename: D J
authors.initials: DJ
authors.lastname: Woods
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage*; D002177:Candidiasis / Q000150:complications / Q000188:drug therapy*; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage*; D006801:Humans; D009403:Nephrostomy, Percutaneous / Q000295:instrumentation; D051437:Renal Insufficiency / Q000150:complications; D014552:Urinary Tract Infections / Q000150:complications / Q000188:drug therapy*
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole