Increased soluble CD23 molecules in serum/saliva and correlation with the stage of sialoectasis in patients with primary Sjögren's syndrome.
OBJECTIVE
We examined the soluble CD23 (sCD23) molecules in sera and saliva from patients with Sjögren's syndrome.


METHODS
The determination of sCD23 and other soluble molecules were made by the enzyme-linked immunosorbent assay.


RESULTS
The amounts of sCD23 in the sera/saliva were significantly increased in the patients compared to the controls and the levels were significantly correlated with sialoectasis.


CONCLUSIONS
The findings suggest that increased sCD23 molecules in saliva from patients with Sjögren's syndrome may reflect active sialoectasis.
Takei
M
M
First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
Azuhata
T
T
Yoshimatu
T
T
Shigihara
S
S
Hashimoto
S
S
Horie
T
T
Horikoshi
A
A
Sawada
S
S
D000328:Adult; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008875:Middle Aged; D017455:Receptors, IgE / Q000096:biosynthesis* / Q000097:blood; D012463:Saliva / Q000737:chemistry* / Q000276:immunology; D012469:Salivary Glands / Q000378:metabolism* / Q000473:pathology*; D012859:Sjogren's Syndrome
D007136:Immunoglobulins; D017455:Receptors, IgE