title: In-111 WBC imaging of osteomyelitis in patients with underlying bone scan abnormalities.
abstract: One hundred seven combined In-111 WBC/Tc-99m MDP scans performed on 87 patients with a high clinical suspicion of osteomyelitis were retrospectively reviewed. An 86% sensitivity and a 94% specificity for detecting osteomyelitis were found. In addition, patients were grouped into one of five clinical settings for more detailed analysis: diabetic osteoarthropathy, previous arthroplasty, fracture, overlying skin ulcer, and other etiology. Forty-seven studies were performed while patients received antibiotic therapy without loss of sensitivity for detecting osteomyelitis. Results obtained with scintigraphy compared favorably to other imaging and laboratory studies used to detect osteomyelitis. In conclusion, the combined In-111 WBC/Tc-99m MDP scan is a very sensitive and specific method to detect osteomyelitis in patients with concurrent diabetic osteoarthropathy, fracture, postoperative healing, and overlying skin ulcer. Antibiotic treatment does not appear to adversely affect the sensitivity of these scans.
authors.affiliation: Department of Radiology, Medical College of Wisconsin, Milwaukee 53226, USA.
authors.forename: A
authors.initials: A
authors.lastname: Kolindou
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: K
authors.initials: K
authors.lastname: Ozker
authors.forename: A Z
authors.initials: AZ
authors.lastname: Krasnow
authors.forename: A T
authors.initials: AT
authors.lastname: Isitman
authors.forename: R S
authors.initials: RS
authors.lastname: Hellman
authors.forename: B D
authors.initials: BD
authors.lastname: Collier
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001178:Arthroplasty; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D048909:Diabetes Complications; D003952:Diagnostic Imaging; D005260:Female; D050723:Fractures, Bone / Q000150:complications; D006801:Humans; D007205:Indium Radioisotopes; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000150:complications / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012883:Skin Ulcer / Q000150:complications; D013669:Technetium Tc 99m Medronate
chemical_list: D000900:Anti-Bacterial Agents; D007205:Indium Radioisotopes; D013669:Technetium Tc 99m Medronate