Effects of benzodiazepine receptor ligands on isolated rat superior cervical ganglia neurons.
We studied the effects of diazepam, CL 218,872, Ro 15-1788, beta-CCM and Ro 15-4513 on the gamma-aminobutyric acid-activated current in adult and newborn rat superior cervical ganglion neurons. Diazepam (10-1,000 nmol/l) potentiated the current in a concentration-dependent manner. CL 218,872 was less effective and weaker than diazepam. The other ligands reduced the amplitude of the current. These peripheral receptors might be involved in some of the side effects of benzodiazepines.
Aguayo
L G
LG
Laboratory of Neuropharmacology, Catholic University at Valparaiso, Chile.
Cisternas
C
C
Tapia
J C
JC
Pancetti
F C
FC
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004594:Electrophysiology; D005442:Flumazenil / Q000494:pharmacology; D008024:Ligands; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D011724:Pyridazines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000378:metabolism* / Q000502:physiology; D017783:Superior Cervical Ganglion / Q000187:drug effects* / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D008024:Ligands; D011724:Pyridazines; D011963:Receptors, GABA-A; D005442:Flumazenil; D005680:gamma-Aminobutyric Acid; C021604:CL 218872; D003975:Diazepam