title: Identification of cyclic cystathionine sulfoxide and N-acetylcyclic cystathionine in the urine of a patient with cystathioninuria using liquid chromatography-mass spectrometry with an atmospheric pressure chemical ionization interface system.
abstract: Perhydro-1,4-thiazepine-4,5-dicarboxylic acid sulfoxide (cyclic cystathionine sulfoxide [cyclic cystaSO]) and N-acetylperhydro-1,4-thiazepine-3,5-dicarboxylic acid (NAc-cyclic cysta) have been identified in the urine of a patient with cystathioninuria as new metabolites of cystathionine for the first time using liquid chromatography-mass spectrometry with an atmospheric pressure chemical ionization interface system (LC/APCI-MS). The concentrations of cyclic cystaSO and NAc-cyclic cysta in the urine of a patient with cystathioninuria have also been determined for the first time using this method: 18.24 +/- 0.79 and 25.23 +/- 0.83 mg/g creatinine, respectively.
authors.affiliation: Department of Chemistry, Kochi Medical School, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: K
authors.initials: K
authors.lastname: Sugahara
authors.forename: Y
authors.initials: Y
authors.lastname: Sagara
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: N
authors.initials: N
authors.lastname: Masuoka
authors.forename: H
authors.initials: H
authors.lastname: Kodama
mesh_terms: D001274:Atmospheric Pressure; D002621:Chemistry / Q000379:methods; D002853:Chromatography, Liquid; D003540:Cystathionine / Q000031:analogs & derivatives* / Q000652:urine*; D005260:Female; D006801:Humans; D013058:Mass Spectrometry; D009994:Osmolar Concentration
chemical_list: D003540:Cystathionine; C010094:cystathionine sulfoxide