The interaction of quinacrine with triple-stranded poly(U).poly(A).poly(U).
The interaction of the antimalarial drug quinacrine (QAC) with triple-stranded poly(U).poly(A).poly(U)(poly(U.A.U)) has been investigated by absorption, fluorescence and circular dichroism (CD) measurements. The results indicate that QAC binds to poly(U.A.U), as well as double-stranded poly (A).poly(U) (poly(A.U)) and poly(I).poly(C) (poly(I.C)). It is concluded that the acridine ring of QAC intercalates into successive U.A.U base-triplets from the minor groove, because the third-strand poly(U) in the major groove of poly(A.U) inhibits the binding of QAC to the major groove.
Tani
S
S
Department of Chemistry, Faculty of Science, Yamaguchi University, Japan.
Kubota
Y
Y
D000962:Antimalarials / Q000737:chemistry; D001665:Binding Sites; D002942:Circular Dichroism; D007364:Intercalating Agents / Q000737:chemistry; D015394:Molecular Structure; D011131:Polyribonucleotides / Q000737:chemistry*; D011796:Quinacrine / Q000737:chemistry*; D013053:Spectrophotometry
D000962:Antimalarials; D007364:Intercalating Agents; D011131:Polyribonucleotides; C063025:poly(U).poly(A).poly(U); D011796:Quinacrine