Protective effects of BQ-123, an ETA receptor antagonist, against leukotoxin-induced injury in rat lungs.
We tested the hypothesis that BQ-123, a novel endothelin type A (ETA) receptor antagonist, protects the lung against leukotoxin 9,10-epoxy-12-octadecenoate (Lx), which causes acute lung injury in animals. In isolated rat lungs perfused with Earle's balanced salt solution, BQ-123 suppressed the Lx-induced increase in wet lung weight, wet lung weight/dry lung weight, the effluent perfusate lactic dehydrogenase activity, and effluent perfusate and lung tissue ET-1 levels. BQ-123 also significantly attenuated the Lx-induced increase of the pulmonary capillary filtration coefficient. Thus our experimental results indicate that the ETA receptor antagonist, BQ-123, protects against Lx-induced experimental lung vascular injury.
Ishizaki
T
T
Department of Internal Medicine, Fukui Medical School, Japan.
Shigemori
K
K
Ameshima
S
S
Nakai
T
T
Miyabo
S
S
Hayakawa
M
M
Ozawa
T
T
Voelkel
N F
NF
D000818:Animals; D065128:Endothelin Receptor Antagonists; D005098:Exotoxins / Q000633:toxicity*; D007166:Immunosuppressive Agents / Q000633:toxicity*; D008168:Lung / Q000187:drug effects / Q000473:pathology*; D008297:Male; D010456:Peptides, Cyclic / Q000008:administration & dosage*; D011654:Pulmonary Edema / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley
D065128:Endothelin Receptor Antagonists; D005098:Exotoxins; D007166:Immunosuppressive Agents; D010456:Peptides, Cyclic; C018579:leukotoxin; C072247:cyclo(Trp-Asp-Pro-Val-Leu)