title: Immunology: resistance to paratuberculosis.
abstract: Disease caused by Mycobacterium paratuberculosis involves a complex interaction of lymphoid and phagocytic cells of the peripheral and mucosal immune responses. For resistance to develop, animals must generate an effective cellular immune response to primary infections as well as multifocal exogenous and endogenous reinfections. If an effective immune response does not develop, infected animals transgress through a complex immunologic spectrum in which the immunologic reactions themselves are responsible for the disease manifestations.
authors.affiliation: International Association for Paratuberculosis, Inc. Rehoboth, Massachusetts, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Chiodini
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology / Q000502:physiology; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology* / Q000503:physiopathology; D004064:Digestive System / Q000382:microbiology / Q000503:physiopathology; D015511:Goat Diseases / Q000276:immunology* / Q000503:physiopathology; D006041:Goats; D006168:Guinea Pigs; D007113:Immunity, Innate; D016927:Mycobacterium avium subsp. paratuberculosis / Q000276:immunology; D010283:Paratuberculosis / Q000276:immunology* / Q000503:physiopathology; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology* / Q000503:physiopathology; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology / Q000502:physiology
chemical_list: D000907:Antibodies, Bacterial