title: Screening of the macromolecular component of CSF from various pathologies for its interference with GABAA receptor function.
abstract: Cerebrospinal fluid (CSF) samples from patients undergoing lumbar puncture for suspected neurological diseases were fractioned into macromolecular (MW > 3000 Daltons) and small molecule components (MW < 3000 Daltons). The macromolecular component was tested for its interference with GABA stimulation of 36Cl- accumulation in rat cerebral cortex microsacs. For many pathologies, no interference was apparent; an exception was two patients with Parkinson's disease in whom there were clear signs of stimulated GABA activity. This last result seems worthy of further investigation.
authors.affiliation: Centro di Neurofisiologia Cerebrale, CNR, Genova, Italy.
authors.forename: M V
authors.initials: MV
authors.lastname: Rapallino
authors.forename: A
authors.initials: A
authors.lastname: Cupello
authors.forename: A
authors.initials: A
authors.lastname: Leonardi
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism; D002555:Cerebrospinal Fluid / Q000737:chemistry*; D002713:Chlorine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid*; D011868:Radioisotopes; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000134:cerebrospinal fluid
chemical_list: D011868:Radioisotopes; D011963:Receptors, GABA-A; D002713:Chlorine; D005680:gamma-Aminobutyric Acid