Chronic neutrophil leukaemia in adolescence and young adulthood.
Chronic neutrophil leukaemia (CNL) is a rare myeloproliferative disorder predominantly reported in elderly patients. We present a 15-year-old girl and a 25-year-old male with CNL. Clonal cytogenetic abnormalities were detected in both patients. One showed trisomy 21 evolving into tetrasomy 21. The second patient showed a unique chromosome aberration during blast crisis: t(2;2)(q32;p24). Both patients were successfully treated with allogeneic bone marrow transplantation (BMT). CNL should also be considered as a differential diagnosis in adolescence and young adulthood. BMT represents a potentially curative treatment option in such patients.
Hasle
H
H
Department of Paediatrics, Danish Cancer Society, Denmark.
Olesen
G
G
Kerndrup
G
G
Philip
P
P
Jacobsen
N
N
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D002869:Chromosome Aberrations; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006801:Humans; D007621:Karyotyping; D015467:Leukemia, Neutrophilic, Chronic / Q000235:genetics* / Q000628:therapy; D008297:Male; D014314:Trisomy