The effect of decoction of Artemisia, Rheum, and Gardeniae in a piglet model of hyperbilirubinemia.
To find an alternative treatment for neonatal hyperbilirubinemia, the effect of a decoction of Artemisia Rheum Gardeniae was tested in an animal model. Fifteen male newborn piglets (four to six days old) were separated into three groups (five piglets/group). The animals of the first group, or Control Group, were intravenously infused with purified bilirubin (40 mg/kg) to simulate neonatal indirect hyperbilirubinemia. The animals of the second and the third groups received the decoction via oral-gastric tube feeding (Enteral Treatment Group) and intravenous injection (Parenteral Treatment Group), respectively, after infusion of bilirubin. Serum bilirubin levels were determined at 0, 0.5, 1, 2, 4 and 8 hours in these groups. The results revealed no significant effect of the decoction on hyperbilirubinemia within eight hours. The implication of this study suggests that a decoction of Artemisia Rheum Gardeniae may be not useful in the treatment of neonatal hyperbilirubinemia.
Kuo
C Y
CY
Department of Pediatrics, Chang Gung Children's Hospital, Taoyuan, R.O.C.
Chang
P C
PC
Wei
J S
JS
D000818:Animals; D000831:Animals, Newborn; D019306:Artemisia; D001663:Bilirubin / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000628:therapy*; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D010946:Plants, Medicinal; D012250:Rheum; D013552:Swine
D010936:Plant Extracts; D001663:Bilirubin