Histopathological effects of illudin S, a toxic substance of poisonous mushroom, in rat.
1. Rats were dosed orally with illudin S, a toxic substance derived from the poisonous mushroom Lampteromyces japonicus. The digestive tract showed severe damage, whereas the liver, kidney and lung did not show any significant changes. 2. The effects observed became more pronounced with increasing illudin S dose (5, 10 or 20 mg kg-1 body weight). 3. Severe inflammation and oedema were observed in the stomach and moderate changes in the proximal part of the small intestine. 4. Histopathological examination revealed haemorrhagic erosions and marked inflammatory oedema in the gastric mucosa.
Tanaka
K
K
National Research Institute of Police Science, Tokyo, Japan.
Miyasaka
S
S
Inoue
T
T
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000187:drug effects* / Q000473:pathology; D008297:Male; D000081223:Polycyclic Sesquiterpenes; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000633:toxicity; D013270:Stomach / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C008105:illudin S