title: Empirical liposomal amphotericin-B therapy in a neutropenic patient: breakthrough of disseminated Blastoschizomyces capitatus infection.
abstract: Blastoschizomyces capitatus (Trichosporon capitatum) is an uncommon fungal pathogen. Infections have mostly been seen in immunocompromised patients and use of broad spectrum antibiotics was identified as a risk factor. Treatment has been extremely difficult. A report is presented about a case of fatal B. capitatum infection with clinical septicemia and multiorgan failure during intravenous liposomal amphotericin B therapy.
authors.affiliation: Institut für Medizinische Mikrobiologie und Hygiene, Köln, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Plum
authors.forename: C
authors.initials: C
authors.lastname: Scheid
authors.forename: C
authors.initials: C
authors.lastname: Franzen
authors.forename: H
authors.initials: H
authors.lastname: Schütt-Gerowitt
authors.forename: H
authors.initials: H
authors.lastname: Seifert
authors.forename: P D
authors.initials: PD
authors.lastname: Wickramanayake
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage*; D004337:Drug Carriers; D017809:Fatal Outcome; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications; D008081:Liposomes; D008297:Male; D009181:Mycoses / Q000188:drug therapy*; D009503:Neutropenia / Q000150:complications; D017211:Treatment Failure; D014250:Trichosporon / Q000302:isolation & purification*
chemical_list: D004337:Drug Carriers; D008081:Liposomes; D000666:Amphotericin B