title: Prevention by cycloheximide of the audiogenic seizures and tryptophan metabolic disturbances of ethanol withdrawal in rats.
abstract: Cycloheximide (20 mg/kg body wt, given intraperitoneally at-1 and 3 h after withdrawal of an ethanol-containing liquid diet) prevents the activation of liver tryptophan pyrrolase, the consequent inhibition of synthesis of brain 5-hydroxytryptamine, and the audiogenic seizures observed at 7 h after alcohol withdrawal. We suggest that a rapidly-turning-over protein mediates the alcohol withdrawal syndrome and discuss the possible role of liver tryptophan pyrrolase.
authors.affiliation: Department of Psychological Medicine, University of Wales College of Medicine, Health Park, Cardiff, UK.
authors.forename: R
authors.initials: R
authors.lastname: Oretti
authors.forename: S
authors.initials: S
authors.lastname: Bano
authors.forename: C J
authors.initials: CJ
authors.lastname: Morgan
authors.forename: A A
authors.initials: AA
authors.lastname: Badawy
authors.forename: A
authors.initials: A
authors.lastname: Bonner
authors.forename: P
authors.initials: P
authors.lastname: Buckland
authors.forename: P
authors.initials: P
authors.lastname: McGuffin
mesh_terms: D000161:Acoustic Stimulation; D000430:Alcohol Withdrawal Delirium / Q000503:physiopathology* / Q000517:prevention & control; D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000503:physiopathology* / Q000517:prevention & control; D012701:Serotonin / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism*; D014366:Tryptophan Oxygenase / Q000037:antagonists & inhibitors / Q000502:physiology
chemical_list: D011500:Protein Synthesis Inhibitors; D012701:Serotonin; D014364:Tryptophan; D003513:Cycloheximide; D014366:Tryptophan Oxygenase