title: Reduced renal fractional excretion of lithium in cystic fibrosis.
abstract: We hypothesized that patients with cystic fibrosis would have abnormal lithium handling because the genetic defect in cystic fibrosis encodes an ion channel which causes a generalized electrolyte transport disorder in epithelial membranes. Eight patients with cystic fibrosis and eight age-sex matched healthy subjects ingested 600 mg lithium carbonate and had urine and serum lithium levels assessed 24 h later. Compared with healthy subjects, the patients with cystic fibrosis had higher serum lithium levels (0.071 +/- 0.038 vs 0.113 +/- 0.055 mmol l-1, P = 0.03) and had lower fractional renal excretion of lithium (27.5 +/- 14.8 vs 18.8 +/- 9.3%, P = 0.03). Caution should be used in prescribing standard doses of lithium to patients with cystic fibrosis until more definitive data are available.
authors.affiliation: Department of Psychiatry, University of Calgary, Alberta, Canada.
authors.forename: N P
authors.initials: NP
authors.lastname: Brager
authors.forename: N R
authors.initials: NR
authors.lastname: Campbell
authors.forename: H
authors.initials: H
authors.lastname: Reisch
authors.forename: M
authors.initials: M
authors.lastname: Chaudhuri
authors.forename: H R
authors.initials: HR
authors.lastname: Rabin
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000097:blood / Q000652:urine*; D005260:Female; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008094:Lithium / Q000097:blood / Q000652:urine*; D016651:Lithium Carbonate / Q000008:administration & dosage / Q000493:pharmacokinetics; D008297:Male
chemical_list: D016651:Lithium Carbonate; D008094:Lithium