Periodontal tissue engineering by growth factors.
Polypeptide growth factors (GFs) have been shown to modulate the wound healing response in both hard and soft tissues. During the past decade, many investigators have demonstrated the anabolic effects of these wound healing molecules on the promotion of periodontal attachment structures, namely alveolar bone, periodontal ligament and tooth root cementum. The molecular cloning and large scale purification of GFs has allowed expanded in vivo studies on periodontal tissue regeneration. This review will outline specific effects of these factors at both the in vitro and in vivo level on the promotion of periodontal and peri-implant bone wound healing. This paper will conclude with a future perspective of ongoing studies in the human clinical trial arena using growth and osteoinductive factors to promote periodontal tissue regeneration and alveolar bone repair in the oral cavity.
Giannobile
W V
WV
Department of Periodontology, Harvard School of Dental Medicine, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.
D000818:Animals; D001698:Biomedical Engineering; D001861:Bone Regeneration / Q000502:physiology; D002986:Clinical Trials as Topic; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D010006:Osteoblasts / Q000502:physiology; D010519:Periodontium / Q000502:physiology*; D010982:Platelet-Derived Growth Factor / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*
D006133:Growth Substances; D010982:Platelet-Derived Growth Factor