title: Limb-sparing treatment for soft tissue sarcomas: influence of prognostic factors.
abstract: At present, limb-sparing surgery is the most appropriate and acceptable treatment available for sarcomas of the extremities, although the right balance between conservative therapy and maximum efficacy has yet to be found. A better knowledge of prognostic factors may help in planning the appropriate strategy for each case. Eighty patients underwent limb-sparing surgery for limb sarcomas (17 had surgery alone; 19 had neoadjuvant hyperthermic antiblastic perfusion combined or not with postoperative radiotherapy, and 44 had adjuvant radiotherapy). Univariate and multivariate analyses were made to detect statistically significant differences between subgroups and identify the more significant subset of prognostic factors. Only microscopically positive surgical margins were related to a greater risk of local recurrence, whereas overall survival was compromised by high grade and large tumor size.
authors.affiliation: Second Surgery Clinic, University of Padua, Italy.
authors.forename: C R
authors.initials: CR
authors.lastname: Rossi
authors.forename: M
authors.initials: M
authors.lastname: Foletto
authors.forename: S
authors.initials: S
authors.lastname: Alessio
authors.forename: N
authors.initials: N
authors.lastname: Menin
authors.forename: E
authors.initials: E
authors.lastname: D'Amore
authors.forename: A
authors.initials: A
authors.lastname: Rigon
authors.forename: M
authors.initials: M
authors.lastname: Lise
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005121:Extremities / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D011379:Prognosis; D012509:Sarcoma / Q000401:mortality / Q000601:surgery*; D012983:Soft Tissue Neoplasms / Q000401:mortality / Q000601:surgery*; D016896:Treatment Outcome