Intracellular regulation of plasticity in Helix.
An increase of PKA activity in the cytoplasmic membrane and nuclei of the CNS conditioned snails was shown. We also found that c-fos as present in the Helix CNS, and its expression is enhanced during learning. A translocation of the PKA catalytic subunit into the nuclei and an activation of the c-fos expression might underlie the long-term plasticity in Helix.
Grinkevich
L N
LN
Computer Technology Research Institute, Institute of Cytology and Genetics, Siberian Branch of the RAS, Novosibirsk, Russia.
Lisachov
P D
PD
Nagibneva
I N
IN
Toporkova
L D
LD
D000818:Animals; D002467:Cell Nucleus / Q000201:enzymology; D002490:Central Nervous System / Q000502:physiology; D003213:Conditioning, Psychological / Q000502:physiology; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D003593:Cytoplasm / Q000201:enzymology; D015870:Gene Expression; D016762:Genes, fos; D006372:Helix, Snails / Q000235:genetics / Q000502:physiology*; D007858:Learning / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015290:Second Messenger Systems / Q000502:physiology
D012333:RNA, Messenger; D017868:Cyclic AMP-Dependent Protein Kinases