title: A new magnetic resonance imaging analysis method for the measurement of disc height variations.
abstract: METHODS
  A new magnetic resonance image analysis method is proposed which is based on the definition of the borders of the vertebral bodies adjacent to the intervertebral disc and their varying relationships. The reproducibility of this method (the so-called "centroid" method) was assessed by consecutive measurements. Its potential to depict diurnal disc height variations was studied using randomized groups of volunteers.
  
  
  OBJECTIVE
  To determine if magnetic resonance imaging can reliably measure disc height variations in the lumbar spine in vivo.
  
  
  BACKGROUND
  A review of the literature indicates that noninvasive, accurate methods to study the effect of load on intervertebral discs in vivo are needed.
  
  
  METHODS
  The reproducibility of the centroid method was assessed in 10 healthy volunteers in 2 consecutive measurements and compared to a conventional method (mean anterior and posterior disc height). To investigate the potential for the depiction of diurnal disc height variations, 10 volunteers were randomized in a study group (1 measurement in the morning, 1 measurement in the evening) and a control group (2 consecutive measurements in the morning).
  
  
  RESULTS
  The centroid method allows the depiction of disc height variations as small as 0.85 mm with a 95% confidence (tolerance limits), whereas a conventional method needs variations of at least 1.66 mm. In the study (diurnal) group, the disc height decreased significantly (P < 0.0001) during the day (mean, -0.9 mm), while no variation (P < 0.8) was found in the control group.
  
  
  CONCLUSIONS
  These results indicate that the centroid method can reliably detect disc height variations in an experimental setting. The centroid method provides the potential for evaluations of the effects of various work places, work equipment, work tasks, and postures.
authors.affiliation: Department of Orthopaedic Surgery, University of Bern, Switzerland.
authors.forename: N
authors.initials: N
authors.lastname: Boos
authors.forename: A
authors.initials: A
authors.lastname: Wallin
authors.forename: M
authors.initials: M
authors.lastname: Aebi
authors.forename: C
authors.initials: C
authors.lastname: Boesch
mesh_terms: D000328:Adult; D000886:Anthropometry; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007403:Intervertebral Disc / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011859:Radiography; D012016:Reference Values; D015203:Reproducibility of Results