Proton and potassium transport by H+/K(+)-ATPases.
1. H+/K(+)-ATPases are members of the P-type ATPase multigene family. The prototypical H+/K(+)-ATPase is the protein that acidifies gastric luminal contents. The physiological and pharmacological significance of this pump has led to a detailed investigation of its biochemistry and molecular and cell biology. 2. Recently, a number of closely related H+/K(+)-ATPase isoforms have been discovered. These isoforms are present in organs other than the stomach, including the colon and kidney, where they contribute to acid-base and potassium homeostasis. The structure, expression and physiological roles of the gastric H+/K(+)-ATPase and other isoforms are reviewed.
van Driel
I R
IR
Department of Pathology and Immunology, Monash University Medical School, Melbourne, Victoria, Australia.
Callaghan
J M
JM
D000818:Animals; D003106:Colon / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D017506:H(+)-K(+)-Exchanging ATPase / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D017136:Ion Transport; D015394:Molecular Structure; D011188:Potassium / Q000378:metabolism*; D011522:Protons
D011522:Protons; D017506:H(+)-K(+)-Exchanging ATPase; D011188:Potassium