Unsuspected multiple sclerosis in patients with psychiatric disorders: a magnetic resonance imaging study.
Over a 6-year period, 2,783 subjects, consecutively referred from the inpatient unit of a private psychiatric hospital, were evaluated with brain MRI. Twenty-three patients (0.83%) had brain white matter hyperintensities (WMH) that were highly suggestive of multiple sclerosis (MS). The subjects with WMH consistent with MS were most commonly diagnosed with affective illness. They had a significantly longer length of hospital stay during the index admission, a greater number of past psychiatric admissions, a greater prevalence of brain atrophy, and a history of more frequent neurological symptoms and signs than those without these findings.
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McLean Brain Imaging Center, Belmont, Massachusetts 02178, USA.
Seol
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Byun
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Renshaw
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D000293:Adolescent; D000328:Adult; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D007902:Length of Stay; D008279:Magnetic Resonance Imaging; D008297:Male; D001523:Mental Disorders / Q000150:complications / Q000473:pathology* / Q000523:psychology; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000473:pathology* / Q000523:psychology; D011619:Psychotropic Drugs / Q000627:therapeutic use
D011619:Psychotropic Drugs