Biological evaluation of mechanical circulatory support systems in calves.
Data from animal experiments with mechanical circulatory support systems (MCSS) performed in Groningen and Marseille over the past years were used to obtain normal values of hematological, coagulation, rheological and blood chemistry parameters in calves. These parameters were divided between two groups: a limited number of parameters necessary to assess biocompatibility properties of MCSS quickly and a more extensive number of parameters suitable for more detailed biological evaluation of blood pumps. All applied tests can be examined in calf blood as well as in human blood. Parameters were selected on clinical relevance and usefulness for standardization procedures. The obtained data were compared with normal values in human beings derived from the literature.
Rakhorst
G
G
Center for Biomedical Technology, University of Groningen, The Netherlands.
van der Meer
J
J
Kik
C
C
Mihaylov
D
D
Havlik
P
P
Trinkl
J
J
Monties
J R
JR
D000818:Animals; D000990:Antithrombin III / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000097:blood; D002417:Cattle; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D004906:Erythrocyte Count; D005112:Extracorporeal Circulation / Q000592:standards*; D006353:Heart-Assist Devices; D006454:Hemoglobins / Q000378:metabolism; D006487:Hemostasis; D007677:Kidney Function Tests; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007962:Leukocytes / Q000166:cytology; D008021:Life Support Systems / Q000592:standards*; D008111:Liver Function Tests; D010314:Partial Thromboplastin Time; D011516:Prothrombin / Q000378:metabolism; D018570:Risk Assessment; D013927:Thrombosis / Q000473:pathology
D006454:Hemoglobins; D000990:Antithrombin III; D011516:Prothrombin; D003404:Creatinine; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases