[Clozapine for resistant schizophrenia and characteristics of those responding].
Clozapine (Leponex) is an atypical antipsychotic drug which is effective in the treatment of resistant schizophrenia. The most severe side-effect is agranulocytosis, which occurs in 12%. 50 patients with resistant schizophrenia were screened retrospectively in order to characterize features which might help predict good response to the drug. The drug was more effective in young patients with recent onset of illness and short total duration of hospitalization.
Talmon
Y
Y
Psychiatric Day Care Unit, Kaplan Hospital, Rehovot.
Guy
N
N
Wittenberg
N
N
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003024:Clozapine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012559:Schizophrenia / Q000188:drug therapy*
D014150:Antipsychotic Agents; D003024:Clozapine