Antioxidant action of a new flavonic derivative in acute carbon tetrachloride intoxication.
The antioxidant potential of a new flavonic derivative named conventionally theophylline-rutoside [TR-1722] was estimated by the measurement of G-6-Pase activity (marker enzyme for the endoplasmic reticulum), catalase activity (enzyme involved in the antioxidant defence process), and total -SH groups from the hepatic homogenate, using CCl4 as a free radical generating model. To show changes in the permeability of the hepatocyte membrane, the activity of lactate dehydrogenase (LDH) in plasma was determined. The obtained results suggest that TR-1722 acts by curtailing both lipid peroxidation and alkylation processes.
Paduraru
I
I
Department of Biochemistry, University of Medicine and Pharmacy, Iasi, Romania.
Saramet
A
A
Danila
G
G
Nichifor
M
M
Jerca
L
L
Iacobovici
A
A
Ungureanu
D
D
Filip
M
M
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants; D002251:Carbon Tetrachloride / Q000633:toxicity*; D002374:Catalase / Q000378:metabolism; D004338:Drug Combinations; D019298:Glucose-6-Phosphate / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000473:pathology; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012431:Rutin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D013806:Theophylline / Q000737:chemistry / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D004338:Drug Combinations; C068270:theophylline-rutozide; D019298:Glucose-6-Phosphate; D012431:Rutin; D013806:Theophylline; D002251:Carbon Tetrachloride; D007770:L-Lactate Dehydrogenase; D002374:Catalase