title: Effects of oral and intramuscular vitamin K prophylaxis on PIVKA-II assay parameters in breastfed infants in Turkey.
abstract: Protein induced by vitamin K absence (PIVKA-II) has been used for the evaluation of vitamin K deficiency in the newborn. Differing PIVKA-II detection rates in various studies on hemorrhagic disease of the newborn have not been explained satisfactorily. In this study we investigated the PIVKA-II values of 44 healthy breastfed infants, of whom 29 received vitamin K1 either orally (N = 13) or intramuscularly (n = 16), and the remaining 15 constituted the control group. PIVKA-II was detected in 15.3 percent (2/13) of the oral and 25 percent of the (4/16) intramuscular group on the third day of life. The detection rate was 93.3 percent (14/15) in the control group. However, at the one-month follow-up, there were no PIVKA-II positive infants. In conclusion, PIVKA-II positivity among breastfed Turkish infants on the third day of life was high compared to that in other studies, perhaps due to a delay in enzyme maturation related to racial, environmental and nutritional factors.
authors.affiliation: Department of Pediatrics, Ankara University Faculty of Medicine.
authors.forename: N
authors.initials: N
authors.lastname: Uluşahin
authors.forename: S
authors.initials: S
authors.lastname: Arsan
authors.forename: F
authors.initials: F
authors.lastname: Ertogan
mesh_terms: D000284:Administration, Oral; D015415:Biomarkers; D001942:Breast Feeding; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007273:Injections, Intramuscular; D008297:Male; D011498:Protein Precursors / Q000378:metabolism*; D011516:Prothrombin / Q000378:metabolism*; D014421:Turkey; D014812:Vitamin K / Q000008:administration & dosage* / Q000627:therapeutic use; D014813:Vitamin K Deficiency / Q000517:prevention & control*
chemical_list: D015415:Biomarkers; D011498:Protein Precursors; D014812:Vitamin K; C008208:acarboxyprothrombin; D011516:Prothrombin