Influence of skin and muscle lesions on the hepatic cytochrome P450 function in 10 and 60 day-old male Wistar rats.
In 10 and 60 day-old male Wistar rats skin lesions of different extents and muscle lesions lead to decreases in cytochrome P450 concentrations and monooxygenase activities (ethylmorphine N-demethylation and ethoxycoumarin O-deethylation) at least up to 7 days after operation. The extent of the depression was related to the extent of the lesion and independent of the nature of the tissue involved.
Klinger
W
W
Institute of Pharmacology and Toxicology, Friedrich-Schiller-University Jena, Germany.
Karge
E
E
D015660:7-Alkoxycoumarin O-Dealkylase / Q000032:analysis; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism / Q000502:physiology*; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis* / Q000502:physiology*; D005037:Ethylmorphine-N-Demethylase / Q000032:analysis; D008099:Liver / Q000201:enzymology* / Q000502:physiology; D008297:Male; D009132:Muscles / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000473:pathology*
D003577:Cytochrome P-450 Enzyme System; D015660:7-Alkoxycoumarin O-Dealkylase; D005037:Ethylmorphine-N-Demethylase