title: XYY male and hematologic malignancy.
abstract: Two cases of XYY male with refractory anemia with excess of blasts are reported, and previous reported XYY males with hematologic malignancy are reviewed. Altogether 26 cases were collected for analysis: acute myeloid leukemia (10), acute lymphocytic leukemia (seven), acute leukemia (two), chronic myelocytic leukemia (three), myelodysplastic syndrome (three), and essential thrombocythemia (one). The age at the time of diagnosis ranged in age from 7.5 to 81 years. In three of six XYY/XY mosaicism cases, XYY clone was associated with malignancy. However, in two cases XYY clone was not involved. The evidence presented here suggests that the event of an XYY male with hematologic malignancy is incidental rather than a genetic etiology.
authors.affiliation: Department of Cancer Cytogenetics, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Oguma
authors.forename: C
authors.initials: C
authors.lastname: Shigeta
authors.forename: N
authors.initials: N
authors.lastname: Kamada
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000473:pathology*; D002648:Child; D019337:Hematologic Neoplasms / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000473:pathology; D012729:Sex Chromosome Aberrations; D014960:X Chromosome; D014998:Y Chromosome