title: A radioimmunoimaging and MIRD dosimetry treatment planning program for radioimmunotherapy.
abstract: A treatment planning program for radioimmunotherapy employing quantitative Anger camera imaging and the MIRD formalism has been designed and implemented on a clinical nuclear medicine computer. Radionuclide residence times are calculated from linear, mono- and bi-exponential, and cubic spline fits to regional activity versus time curves, and radiation-absorbed dose estimates for all target organs for 131I, 67Cu, and 58 other radionuclides can be calculated. This software has been successfully applied to radioimmunotherapy of B-cell malignancies and breast adenocarcinomas.
authors.affiliation: Siemens Medical Systems, Hoffman Estates, IL 60195-7372, USA.
authors.forename: W D
authors.initials: WD
authors.lastname: Erwin
authors.forename: M W
authors.initials: MW
authors.lastname: Groch
authors.forename: D J
authors.initials: DJ
authors.lastname: Macey
authors.forename: G L
authors.initials: GL
authors.lastname: DeNardo
authors.forename: S J
authors.initials: SJ
authors.lastname: DeNardo
authors.forename: S
authors.initials: S
authors.lastname: Shen
mesh_terms: D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008432:Mathematical Computing; D008954:Models, Biological; D016719:Radioimmunodetection / Q000379:methods*; D016499:Radioimmunotherapy / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D012984:Software