title: High-frequency oscillatory ventilation combined with intermittent mandatory ventilation in critically ill neonates and infants.
abstract: We have evaluated the high-frequency oscillatory ventilation (HFOV) combined with intermittent mandatory ventilation (IMV) in critically ill neonates and infants using the Babylog 8000 SW 4.0. We used HFOV combined with IMV as a rescue mode in 10 neonates and infants aged 1 day to 17 months, who were receiving maximal conventional ventilation for severe respiratory failure. There was a significant reduction in inspired oxygen requirement when starting HFOV combined with intermittent mandatory ventilation (IMV), from a baseline mean of 0.90 (CI95 0.79-1.01) to 0.55 (CI95 0.40-0.71) at 6h and 0.44 (CI95 0.37-0.52) at 12h. There was also an overall improvement in gas exchange with complete haemodynamic stability. These data suggest that HFOV-IMV mode offers significant improvement as a rescue mode for neonates and infants with severe respiratory failure.
authors.affiliation: Cardiac Intensive Care Unit, Royal Liverpool Children's NHS Trust, Alder Hey, UK.
authors.forename: B V
authors.initials: BV
authors.lastname: Murthy
authors.forename: A J
authors.initials: AJ
authors.lastname: Petros
mesh_terms: D000403:Airway Resistance; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D016638:Critical Illness; D006612:High-Frequency Ventilation; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007385:Intermittent Positive-Pressure Ventilation; D010100:Oxygen / Q000097:blood; D012131:Respiratory Insufficiency / Q000097:blood / Q000503:physiopathology / Q000628:therapy
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen