title: Statistical error mapping for reliable quantitative T1 imaging.
abstract: We developed a statistically based error image for rapid appreciation of unreliable regions in quantitative water proton T1 images. The chi-squared error and co-efficient of variation of the fitted parameter were used to estimate uncertainties in the goodness-of-fit to mono-exponential T1 relaxation and the reliability of the calculated T1, respectively, for each pixel. Errors exceeding a statistical threshold based on a .1 acceptance criterion were displayed as a color-coded overlay on the T1 image. Error maps of quantitative T1 images from 31 healthy volunteers showed a characteristic error structure; few pixels within the parenchyma had excessive errors. Clinical cases with stroke and sickle cell disease showed deviations from the normal pattern in the spatial distribution and magnitude of chi-squared errors. Disease states may deviate from mono-exponential T1 relaxation more than normal brain does. The color-coded error map is a valuable tool for investigators using quantitative MR imaging to determine tissue relaxation parameters.
authors.affiliation: Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
authors.forename: W E
authors.initials: WE
authors.lastname: Reddick
authors.forename: R J
authors.initials: RJ
authors.lastname: Ogg
authors.forename: R G
authors.initials: RG
authors.lastname: Steen
authors.forename: J S
authors.initials: JS
authors.lastname: Taylor
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000175:diagnosis; D001921:Brain / Q000033:anatomy & histology / Q000473:pathology; D016009:Chi-Square Distribution; D002648:Child; D003627:Data Interpretation, Statistical; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male