title: The novel neuropeptide orphanin FQ fails to produce conditioned place preference or aversion.
abstract: An unbiased conditioned place preference procedure was used to determine whether the newly-identified neuropeptide orphanin FQ produced motivational effects after intracerebroventricular microinjections. Microinjections of orphanin FQ (0.1-100 nmol) failed to produce conditioned place preference or aversion, but a pronounced motor impairment was observed during conditioning sessions with the two highest doses. Thus, it appears that orphanin FQ lacks motivational effects when administered at behaviourally active doses.
authors.affiliation: Mental Health Research Institute, University of Michigan, Ann Arbor 48109-0720, USA.
authors.forename: D P
authors.initials: DP
authors.lastname: Devine
authors.forename: R K
authors.initials: RK
authors.lastname: Reinscheid
authors.forename: F J
authors.initials: FJ
authors.lastname: Monsma
authors.forename: O
authors.initials: O
authors.lastname: Civelli
authors.forename: H
authors.initials: H
authors.lastname: Akil
mesh_terms: D000818:Animals; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular; D008297:Male; D008845:Microinjections; D009020:Morphine / Q000494:pharmacology; D009042:Motivation; D009043:Motor Activity / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists; D018847:Opioid Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000097629:Nociceptin
chemical_list: D009020:Morphine; D009270:Naloxone; D009292:Narcotic Antagonists; D018847:Opioid Peptides; D000097629:Nociceptin