The effect of chloroform-extractable secondary metabolites of filamentous fungi on the movement of respiratory tract cilia of one-day-old chicks in vitro.
The ciliostatic activity of the chloroform-extractable metabolites of 72 strains of filamentous fungi growing in a liquid medium, on tracheal cilia from 1-d-old chicks in vitro was evaluated. Forty-eight of the investigated strains produced ciliostatic metabolites; 13, 11, 16, and 25% of the strains stopped the movement of cilia after 1, 2, 3, 6 d, respectively. The results are discussed in relationship with chronic bronchitis of people working with mouldy materials, living in mouldy dwellings and with the "sick-building syndrome".
Piecková
E
E
Institute of Preventive and Clinical Medicine, Bratislava, Slovakia.
Jesenská
Z
Z
D000818:Animals; D000831:Animals, Newborn; D002645:Chickens; D002725:Chloroform; D002923:Cilia / Q000187:drug effects* / Q000502:physiology*; D005658:Fungi / Q000378:metabolism* / Q000472:pathogenicity*; D006801:Humans; D066298:In Vitro Techniques; D009183:Mycotoxins / Q000302:isolation & purification / Q000633:toxicity*; D012137:Respiratory System / Q000187:drug effects* / Q000503:physiopathology*; D018877:Sick Building Syndrome / Q000209:etiology; D014132:Trachea / Q000187:drug effects / Q000503:physiopathology
D009183:Mycotoxins; D002725:Chloroform