GSH transporters: molecular characterization and role in GSH homeostasis.
Considerable progress has been made in the last few years in the molecular identification and characterization of hepatic GSH transporter-associated polypeptides. We are now poised to determine their precise mechanisms of action and regulation at the transcriptional and post-translational level. It is also anticipated that molecular characterization of the mitochondrial GSH transporter and sodium GSH co-transporters will be accomplished in the near future. With this information, a more complete understanding of GSH/cysteine homeostasis can be achieved which can be applied to furthering the prevention and treatment of the diseases of oxidative stress, such as aging, HIV, cataract, atherosclerosis, cancer and alcoholic liver disease.
Kaplowitz
N
N
USC Center for Liver Diseases, USC School of Medicine, Los Angeles, 90033-4581, USA.
Fernández-Checa
J C
JC
Kannan
R
R
Garcia-Ruiz
C
C
Ookhtens
M
M
Yi
J R
JR
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D005978:Glutathione / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000378:metabolism; D026901:Membrane Transport Proteins
D002352:Carrier Proteins; D026901:Membrane Transport Proteins; C086860:glutathione transporter; D005978:Glutathione