[Pneumocystis carinii pneumonia in a HTLV-I carrier with monoclonal proliferation of HTLV-I infected lymphocyte].
A 63-year-old woman had Pneumocystis carinii pneumonia without any apparent underlying disease such as cancers or HIV infection. Although she reacted positively for HTLV-I antibody, hematological findings and clinical symptoms did not suggest that this patient had an ATL. Southern blot analysis revealed that HTLV-I infected lymphocytes had already proliferated monoclonally. The development of overt ATL should be carefully monitored in this type of patient as Pneumocystis carinii infection in HTLV-I carriers were reported to be a predictive sign of ATL and the monoclonal integration of a HTLV-I genome in the lymphocytes in this patient also suggests the presence of neoplastic clone.
Kawahigashi
N
N
Department of Internal Medicine, Kagoshima City Hospital.
Furukawa
Y
Y
Tara
M
M
Niina
K
K
D015139:Blotting, Southern; D002353:Carrier State; D005260:Female; D015481:HTLV-I Antibodies / Q000032:analysis; D015490:HTLV-I Infections / Q000150:complications*; D015368:Human T-lymphotropic virus 1; D006801:Humans; D008214:Lymphocytes / Q000821:virology; D008232:Lymphoproliferative Disorders / Q000821:virology*; D008875:Middle Aged; D011020:Pneumonia, Pneumocystis / Q000150:complications*
D015481:HTLV-I Antibodies