Intracellular signalling: more jobs for G beta gamma.
G-protein-coupled receptors that modulate Ca2+ channels that mediate synaptic transmission seem to use the G beta gamma, and not the G alpha, subunits of the trimeric G protein to slow and inhibit the Ca2+ currents.
Clapham
D E
DE
Department of Pharmacology, Mayo Foundation, Rochester, Minnesota 55905, USA.
D015220:Calcium Channels / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D015220:Calcium Channels; D019204:GTP-Binding Proteins