Combination therapy with cyclosporine in rheumatoid arthritis.
The role of combination therapy in rheumatoid arthritis is increasing with the recent development of various new treatment modalities. While past combinations of slow acting antirheumatic drugs have resulted in either excessive side effects or lack of efficacy over single agent therapy, recent combinations appear more promising. Recently, the combination of cyclosporine and methotrexate (MTX) was shown to be more efficacious than MTX alone. Improved methodology and a better understanding of the mechanisms of action of these newer agents is responsible for these exciting results.
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Department of Medicine, Arizona Arthritis Center University of Arizona, Tucson, USA.
D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D016572:Cyclosporine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005544:Forecasting; D006801:Humans
D018501:Antirheumatic Agents; D016572:Cyclosporine