Acromegalic pregnancy associated with a Beckwith-Wiedemann fetus.
BACKGROUND
Beckwith-Wiedemann syndrome is a rare serious condition with a high rate of malignant tumors. A relationship between Beckwith-Wiedemann syndrome and insulin-like growth factor (IGF) II gene located at the level of the 11p15 chromosomic region has been demonstrated.


METHODS
An acromegalic woman (elevated IGF I serum levels) undergoing pregnancy with a Beckwith-Wiedemann fetus is reported. We therefore reviewed data about this association and particularly fetal growth, and analyzed fetal blood samples for IGF I and II.


CONCLUSIONS
We conclude that this association (i.e. Beckwith-Wiedemann syndrome and acromegaly) is independent, and point out that IGF I and II might be very high in the Beckwith-Wiedemann fetus.
Luton
D
D
Maternité de l'Hôpital Robert-Debré, Paris, France.
Lepercq
J
J
Sibony
O
O
Barbet
P
P
Le Bouc
Y
Y
Chavinié
J
J
Lewin
F
F
D000172:Acromegaly / Q000097:blood*; D000328:Adult; D001506:Beckwith-Wiedemann Syndrome / Q000235:genetics*; D005260:Female; D005315:Fetal Diseases / Q000235:genetics; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007335:Insulin-Like Growth Factor II / Q000235:genetics; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood
D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II