title: A unique human gene that spans over 230 kb in the human chromosome 8p11-12 and codes multiple family proteins sharing RNA-binding motifs.
abstract: A unique gene, RBP-MS, spanning over 230 kb in the human chromosome 8p11-12 near the Werner syndrome gene locus is described. The single-copy RBP-MS gene is alternatively spliced, resulting in a family of at least 12 transcripts (average length of 1.5 kb). Nine different types of cDNAs that encode an RNa-binding motif at the N terminus and helix-rich sequences at the C terminus have been identified thus far. Among the 16 exons identified, four 5'-proximal exons contained sequences homologous to the RNA-binding domain of Drosophila couch potato gene. Northern blot analysis showed that the RBP-MS gene was expressed strongly in the heart, prostate, intestine, and ovary, and poorly in the skeletal muscle, spleen, thymus, brain, and peripheral leukocytes. The possible role of this gene in RNA metabolism is discussed.
authors.affiliation: AGENE Research Institute, Kamakura, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Shimamoto
authors.forename: S
authors.initials: S
authors.lastname: Kitao
authors.forename: K
authors.initials: K
authors.lastname: Ichikawa
authors.forename: N
authors.initials: N
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Yamabe
authors.forename: O
authors.initials: O
authors.lastname: Imamura
authors.forename: Y
authors.initials: Y
authors.lastname: Tokutake
authors.forename: M
authors.initials: M
authors.lastname: Satoh
authors.forename: T
authors.initials: T
authors.lastname: Matsumoto
authors.forename: J
authors.initials: J
authors.lastname: Kuromitsu
authors.forename: H
authors.initials: H
authors.lastname: Kataoka
authors.forename: K
authors.initials: K
authors.lastname: Sugawara
authors.forename: M
authors.initials: M
authors.lastname: Sugawara
authors.forename: M
authors.initials: M
authors.lastname: Sugimoto
authors.forename: M
authors.initials: M
authors.lastname: Goto
authors.forename: Y
authors.initials: Y
authors.lastname: Furuichi
mesh_terms: D017398:Alternative Splicing; D000595:Amino Acid Sequence; D001483:Base Sequence; D002898:Chromosomes, Human, Pair 8; D003001:Cloning, Molecular; D005091:Exons; D015870:Gene Expression; D005796:Genes; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics; D016601:RNA-Binding Proteins / Q000235:genetics*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution; D014898:Werner Syndrome / Q000235:genetics
chemical_list: C101827:RBPMS protein, human; D012333:RNA, Messenger; D016601:RNA-Binding Proteins