Efficacy and toxicity of radiation in preparative regimens for pediatric stem cell transplantation. I: Clinical applications and therapeutic effects.
Here, we review the role of total body irradiation in the treatment of children with bone marrow transplantation, as well as alternative sources of stem cells. We were unable to demonstrate any clear superiority of TBI-containing preparative regimens, but we were able to find a few definitive reports of significantly enhanced toxicity or important variations in control of the underlying primary diseases, in comparing TBI-based regimens, with those containing only chemotherapy.
Miale
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TD
Department of Pediatrics, University of Tennessee Medical Center at Knoxville, USA.
Sirithorn
S
S
Ahmed
S
S
D000328:Adult; D016465:Bone Marrow Purging / Q000379:methods*; D002648:Child; D004307:Dose-Response Relationship, Radiation; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000601:surgery*; D014916:Whole-Body Irradiation / Q000009:adverse effects* / Q000379:methods*