Isolation and semi-synthesis of a bioactive taxane from Taxus canadensis.
A minor bioactive taxane, isolated from the needles of Taxus canadensis and semi-synthesized, was shown to be taxcultine.
Zamir
L O
LO
Institut Armand-Frappier, Université du Québec, Laval-des-Rapides, Canada.
Nedea
M E
ME
Zhou
Z H
ZH
Caron
G
G
Sauriol
F
F
Mamer
O
O
D000818:Animals; D001921:Brain / Q000187:drug effects; D002417:Cattle; D009682:Magnetic Resonance Spectroscopy; D008870:Microtubules / Q000187:drug effects; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification; D016339:Spectrometry, Mass, Fast Atom Bombardment; D043823:Taxoids; D014197:Trees / Q000737:chemistry*
D043823:Taxoids; C103052:taxcultine; D017239:Paclitaxel