title: Urticaria from allergy to a purified human anti-Rh antibody preparation.
abstract: This case presentation describes a young woman who developed generalized urticaria after receiving the human anti-RhD(D) preparation, WinRho, intravenously. Allergy skin tests and the radioallergosorbent test (RAST) for IgE antibodies to the human anti-D immunoglobulin preparation were positive. Further studies using high-pressure liquid chromatography and protein A column chromatography implicated a nonimmunoglobulin low-molecular-weight contaminant. This case report illustrates an allergic reaction to a highly purified human immunoglobulin preparation, and demonstrates approaches to assessment of such a reaction.
authors.affiliation: Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
authors.forename: I
authors.initials: I
authors.lastname: Sulakvelidze
authors.forename: S
authors.initials: S
authors.lastname: Evans
authors.forename: I
authors.initials: I
authors.lastname: Switzer
authors.forename: B
authors.initials: B
authors.lastname: Underdown
authors.forename: J
authors.initials: J
authors.lastname: Greenbaum
authors.forename: J
authors.initials: J
authors.lastname: Dolovich
mesh_terms: D000328:Adult; D002170:Canada; D004340:Drug Contamination; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007518:Isoantibodies / Q000009:adverse effects* / Q000276:immunology; D011852:Radioallergosorbent Test; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin / Q000009:adverse effects* / Q000276:immunology; D012882:Skin Tests; D014581:Urticaria / Q000209:etiology*
chemical_list: D007518:Isoantibodies; C033242:RH-antibodies; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin; D007073:Immunoglobulin E