title: Magnetic resonance imaging of massive bone allografts with histologic correlation.
abstract: OBJECTIVE
  The objective of this study was to better understand the MRI appearance of massive bone allografts.
  
  
  METHODS
  The MRI findings of three massive bone allografts imaged in vivo were correlated with the histologic findings following removal of the allografts. A fourth allograft, never implanted, was imaged and evaluated histologically.
  
  
  METHODS
  Allografts were placed for the treatment of primary or recurrent osteosarcoma.
  
  
  CONCLUSIONS
  The in-vivo allografts have a heterogeneous appearance on MRI which we attribute to the revascularization process. Fibrovascular connective tissue grows into the graft in a patchy, focal fashion, down the medullary canal from the graft-host junction and adjacent of the periosteum. The marrow spacers are initially devoid of normal cellular elements and occupied by fat and gelatinous material. This normal postoperative appearance of massive bone allografts must be interpreted as recurrent neoplasm or infection in the allograft. Recognition of these complications rests on features outside the marrow.
authors.affiliation: Department of Radiology, Wayne State University School of Medicine, Detroit, Michigan, USA.
authors.forename: E G
authors.initials: EG
authors.lastname: Hoeffner
authors.forename: J R
authors.initials: JR
authors.lastname: Ryan
authors.forename: F
authors.initials: F
authors.lastname: Qureshi
authors.forename: R L
authors.initials: RL
authors.lastname: Soulen
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D001859:Bone Neoplasms / Q000473:pathology* / Q000601:surgery*; D016025:Bone Transplantation / Q000473:pathology*; D005269:Femur / Q000473:pathology* / Q000637:transplantation; D006801:Humans; D008279:Magnetic Resonance Imaging; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery; D012516:Osteosarcoma / Q000473:pathology* / Q000601:surgery*; D014184:Transplantation, Homologous