The relation between nuclear gene expression and calcium ion in osteoblastic MC3T3-E1 cells.
The effect of calcium ionophore, A23187, on c-fos mRNA expression was examined in the osteoblastic MC3T3-E1 cells. We found that the calcium concentration of the medium is related to the c-fos mRNA expression by A23187.
Deyama
Y
Y
Department of Dental Pharmacology, School of Dentistry, Hokkaido University, Sapporo, Japan.
Matsumoto
A
A
Yoshimura
Y
Y
Suzuki
K
K
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism* / Q000494:pharmacology; D002460:Cell Line; D015870:Gene Expression / Q000187:drug effects; D016762:Genes, fos / Q000187:drug effects*; D007476:Ionophores / Q000494:pharmacology; D051379:Mice; D010006:Osteoblasts / Q000187:drug effects / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
D007476:Ionophores; D012333:RNA, Messenger; D000001:Calcimycin; D002118:Calcium