title: Structural studies of mitomycins. VIII. Mitomycin D hydrate, C15H18N4O5.1.5H2O.
abstract: The title compound, [1aS]-6-amino-1, 1a,2,4,7,8,8a,8b-octahydro-8a-hydroxy-1,5-dimethyl-4,7-dioxoazirino++ +[2',-3': 3,4]pyrrolo[1,2-a]indol-7-ylmethyl, is a mitomycin derivative, mitomycins being antitumor antibiotics. The O atoms of the quinone ring deviate significantly from the least-squares plane through the quinone ring.
authors.affiliation: Department of Biological Science and Technology, Tokai University, Shizouka, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Hirayama
authors.forename: H
authors.initials: H
authors.lastname: Arai
authors.forename: M
authors.initials: M
authors.lastname: Kasai
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008937:Mitomycins / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000903:Antibiotics, Antineoplastic; D008937:Mitomycins; C102065:mitomycin D