title: Selective suppression of in vitro T-dependent humoral immunity by synthetic food additive antioxidants.
abstract: Effect of antioxidants on humoral immune responses, such as butylated hydroxytoluene (BHT), n-propyl gallate (PG) and dimethyl sulfoxide (DMSO) is suppression in vitro antibody production. These antioxidants all inhibited T-dependent B cell response, not T-independent and polyclonal B cell response. These data suggest that antioxidants suppress humoral immunity by suppression of regulation of T cells or action of macrophages on B cells, not by direct suppression of B cells. The other possible explanation for antioxidant action is the lack of T-B cell contact required for the triggering of the B cell response with T-dependent antigens.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, Taejon City.
authors.forename: H M
authors.initials: HM
authors.lastname: Kim
authors.forename: S B
authors.initials: SB
authors.lastname: Han
authors.forename: W I
authors.initials: WI
authors.lastname: Chang
authors.forename: B H
authors.initials: BH
authors.lastname: Hyun
authors.forename: G T
authors.initials: GT
authors.lastname: Oh
authors.forename: C J
authors.initials: CJ
authors.lastname: Ahn
authors.forename: Y N
authors.initials: YN
authors.lastname: Cha
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000975:Antioxidants / Q000633:toxicity*; D002084:Butylated Hydroxytoluene / Q000633:toxicity*; D004121:Dimethyl Sulfoxide / Q000633:toxicity*; D005520:Food Preservatives / Q000633:toxicity*; D051379:Mice; D011435:Propyl Gallate / Q000633:toxicity*; D013154:Spleen / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects*
chemical_list: D000975:Antioxidants; D005520:Food Preservatives; D002084:Butylated Hydroxytoluene; D011435:Propyl Gallate; D004121:Dimethyl Sulfoxide