IgG glycosylation in association with tropical infections and rheumatoid arthritis in the tropics.
Studies conducted in Europe suggest an association between IgG glycosylation abnormalities and rheumatoid arthritis (RA). Glycosylation abnormalities have been shown in other inflammatory diseases such as tuberculosis, systemic lupus erythematosus (SLE) and Crohn's disease. These observations led us to study glycosylation abnormalities among patients with RA and healthy controls in the tropics (sub-Saharan Africa). Using a lectin binding assay, we found that glycosylation differences were present in both groups when compared with British rheumatoid and healthy controls. This suggests that IgG glycosylation abnormalities may occur in association with chronic infections in the tropics.
Adebajo
A O
AO
Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, U.K.
Hazelman
B L
BL
D000293:Adolescent; D000328:Adult; D000368:Aged; D016918:Arthritis, Reactive / Q000150:complications; D001172:Arthritis, Rheumatoid / Q000208:ethnology / Q000378:metabolism*; D002908:Chronic Disease; D005260:Female; D006031:Glycosylation; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D007074:Immunoglobulin G / Q000097:blood / Q000378:metabolism*; D007239:Infections / Q000150:complications*; D008288:Malaria / Q000150:complications; D008297:Male; D008875:Middle Aged; D009549:Nigeria; D012044:Regression Analysis; D012217:Rheumatoid Factor / Q000378:metabolism*; D014329:Tropical Climate
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D012217:Rheumatoid Factor