Detection of malignant tumors using Tc-99m labeled Fab' fragments from a monoclonal antibody with specificity for D-dimer of cross-linked fibrin.
The authors present the case studies of two patients whose malignant tumors were detected with a Tc-99m labeled antifibrin monoclonal antibody (DD-3B6/22), which is specific for cross-linked fibrin. The first case was a malignant fibrous histiocytoma involving the proximal aspect of the left thigh, whereas in the second case, the patient was receiving treatment for a squamous cell carcinoma of the right mainstem bronchus. The results highlight the potential of this anti-D-dimer radiopharmaceutical for noninvasive detection of malignant tumors.
Angelides
S
S
Department of Nuclear Medicine, Royal Prince Alfred Hospital, Sydney, Australia.
Lee
F T
FT
Basten
A
A
Lambrecht
R M
RM
Walker
K Z
KZ
Bundesen
P G
PG
Bautovich
G J
GJ
D000368:Aged; D001984:Bronchial Neoplasms / Q000000981:diagnostic imaging*; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging*; D005338:Fibrin Fibrinogen Degradation Products / Q000276:immunology*; D018219:Histiocytoma, Benign Fibrous / Q000000981:diagnostic imaging*; D006801:Humans; D007140:Immunoglobulin Fab Fragments; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging; D016719:Radioimmunodetection; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging*; D013667:Technetium; D013848:Thigh; D013924:Thrombophlebitis / Q000000981:diagnostic imaging
D005338:Fibrin Fibrinogen Degradation Products; D007140:Immunoglobulin Fab Fragments; C036309:fibrin fragment D; D013667:Technetium