title: A chronic microelectrode investigation of the tonotopic organization of human auditory cortex.
abstract: We investigated the functional organization of human auditory cortex using a new chronic microelectrode technique. Tonotopic mapping data was obtained at the single unit level for the first time in humans. All sound-driven units were noted to have frequency-dependent response patterns. The majority of units (73%) demonstrated sharply tuned excitatory best-frequency responses. Twenty seven percent of units showed wide receptive fields, representing excitatory responses to almost the entire range of frequencies presented. A tonotopic pattern was observed with best frequencies systematically increasing as more medial-caudal recording sites were sampled.
authors.affiliation: Division of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Howard
authors.forename: I O
authors.initials: IO
authors.lastname: Volkov
authors.forename: P J
authors.initials: PJ
authors.lastname: Abbas
authors.forename: H
authors.initials: H
authors.lastname: Damasio
authors.forename: M C
authors.initials: MC
authors.lastname: Ollendieck
authors.forename: M A
authors.initials: MA
authors.lastname: Granner
mesh_terms: D000161:Acoustic Stimulation; D001303:Auditory Cortex / Q000166:cytology / Q000502:physiology*; D001931:Brain Mapping; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004594:Electrophysiology; D006801:Humans; D008839:Microelectrodes