Treatment-resistant depression in children and adolescents.
Treatment resistance in depressed children and adolescents cannot yet be defined fully because of the paucity of controlled studies that demonstrate efficacy. Therefore, this article addresses several of the age-specific, developmental considerations that may impinge upon treatment response. Areas covered include familial-genetic, psychosocial, and neuroimaging studies in addition to a review of controlled studies to date.
Geller
B
B
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
Todd
R D
RD
Luby
J
J
Botteron
K N
KN
D000293:Adolescent; D000367:Age Factors; D017668:Age of Onset; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000235:genetics; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002648:Child; D015897:Comorbidity; D018849:Controlled Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology / Q000628:therapy; D003952:Diagnostic Imaging; D004351:Drug Resistance; D005192:Family Health; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D019964:Mood Disorders / Q000000981:diagnostic imaging / Q000473:pathology; D010553:Personality Development; D011613:Psychotherapy; D011859:Radiography; D011877:Radionuclide Imaging; D012917:Social Adjustment
D000928:Antidepressive Agents