Sertraline-associated syndrome of inappropriate antidiuretic hormone: case report and review of the literature.
Selective serotonin reuptake inhibitors have gained widespread use in the treatment of depression. A 78-year-old woman became hyponatremic 3 days after being treated with sertraline and was subsequently diagnosed with the syndrome of inappropriate antidiuretic hormone (SIADH). She became symptomatic, but experienced rapid resolution of the laboratory and clinical abnormalities associated with SIADH on discontinuing sertraline and receiving fluid restriction, hypertonic saline, and demeclocycline. Several mechanisms may relate SIADH and vasopressin release to serotonin.
Bradley
M E
ME
Department of Pharmacy Practice and Administration, College of Pharmacy, Rutgers, State University of New Jersey, Piscataway 08855-0789, USA.
Foote
E F
EF
Lee
E N
EN
Merkle
L
L
D015057:1-Naphthylamine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000368:Aged; D000928:Antidepressive Agents / Q000009:adverse effects*; D003866:Depressive Disorder / Q000188:drug therapy; D005260:Female; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced*; D020280:Sertraline; D014667:Vasopressins / Q000378:metabolism
D000928:Antidepressive Agents; D014667:Vasopressins; D015057:1-Naphthylamine; D020280:Sertraline