title: Cyclic ADP-ribose and calcium signaling in eggs.
abstract: Cyclic ADP-ribose is a cyclic nucleotide with Ca2+ signaling functions. It was first discovered in sea urchin eggs and has since been shown to be active in a variety of cells. Another Ca2+ release mechanism recently described in the eggs is mediated by nicotinic acid dinucleotide phosphate, a derivative of NADP+. This article summarizes current results on these two novel Ca(2+)-mobilizing pathways that are independent of inositol trisphosphate.
authors.affiliation: Department of Physiology, University of Minnesota, Minneapolis 55455, USA.
authors.forename: H C
authors.initials: HC
authors.lastname: Lee
mesh_terms: D036541:ADP-ribosyl Cyclase; D051997:ADP-ribosyl Cyclase 1; D000246:Adenosine Diphosphate Ribose / Q000031:analogs & derivatives* / Q000378:metabolism; D000818:Animals; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D036563:Cyclic ADP-Ribose; D009699:N-Glycosyl Hydrolases / Q000378:metabolism; D009249:NADP / Q000031:analogs & derivatives* / Q000378:metabolism; D010063:Ovum / Q000502:physiology*; D012617:Sea Urchins; D015398:Signal Transduction
chemical_list: D015703:Antigens, CD; D000943:Antigens, Differentiation; D036563:Cyclic ADP-Ribose; D000246:Adenosine Diphosphate Ribose; D009249:NADP; C024376:NAADP; D009699:N-Glycosyl Hydrolases; D036541:ADP-ribosyl Cyclase; D051997:ADP-ribosyl Cyclase 1; D002118:Calcium