Myelodysplasia and acute myeloid leukemia occurring after autologous bone marrow transplantation for lymphoma.
Secondary hematopoietic disease manifesting as acute myeloid leukemia, myelodysplastic syndrome or clonal karyotypic abnormalities, has been recently recognized as a relatively frequent and potentially serious complication of autologous bone marrow transplantation for both Hodgkin's disease and non-Hodgkin's lymphoma. The available evidence suggests the disease results primarily from repeated exposure of the host stem cells to therapeutic agents before the time of transplant, but a conspiratory role for the transplantation procedure itself cannot be entirely excluded. Strategies to decrease the incidence of secondary hematopoietic disease include earlier stem cell harvest and/or transplantation, and the performance of screening karyotypic studies on the bone marrow prior to autologous grafting.
Traweek
S T
ST
Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA.
Slovak
M L
ML
Nademanee
A P
AP
Brynes
R K
RK
Niland
J C
JC
Forman
S J
SJ
D000208:Acute Disease; D000970:Antineoplastic Agents / Q000009:adverse effects; D001853:Bone Marrow / Q000473:pathology; D001856:Bone Marrow Examination; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005500:Follow-Up Studies; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000209:etiology* / Q000517:prevention & control; D007953:Leukemia, Radiation-Induced / Q000209:etiology; D008223:Lymphoma / Q000150:complications / Q000235:genetics / Q000628:therapy*; D009190:Myelodysplastic Syndromes / Q000209:etiology*; D018365:Neoplasm, Residual; D016609:Neoplasms, Second Primary / Q000209:etiology* / Q000517:prevention & control; D014411:Neoplastic Stem Cells / Q000637:transplantation; D011878:Radiotherapy / Q000009:adverse effects; D012189:Retrospective Studies; D012307:Risk Factors; D013156:Splenectomy / Q000009:adverse effects; D019172:Transplantation Conditioning / Q000009:adverse effects; D014182:Transplantation, Autologous / Q000009:adverse effects
D000970:Antineoplastic Agents