A radioimmunoimaging and MIRD dosimetry treatment planning program for radioimmunotherapy.
A treatment planning program for radioimmunotherapy employing quantitative Anger camera imaging and the MIRD formalism has been designed and implemented on a clinical nuclear medicine computer. Radionuclide residence times are calculated from linear, mono- and bi-exponential, and cubic spline fits to regional activity versus time curves, and radiation-absorbed dose estimates for all target organs for 131I, 67Cu, and 58 other radionuclides can be calculated. This software has been successfully applied to radioimmunotherapy of B-cell malignancies and breast adenocarcinomas.
Erwin
W D
WD
Siemens Medical Systems, Hoffman Estates, IL 60195-7372, USA.
Groch
M W
MW
Macey
D J
DJ
DeNardo
G L
GL
DeNardo
S J
SJ
Shen
S
S
D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008432:Mathematical Computing; D008954:Models, Biological; D016719:Radioimmunodetection / Q000379:methods*; D016499:Radioimmunotherapy / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D012984:Software