Nausea and vomiting after laparoscopic surgery: a comparison of propofol and thiopentone/halothane anaesthesia.
Sixty ASA I and II patients scheduled for laparoscopic cholecystectomy or inguinal herniotomy were randomly assigned to one of two groups: Group one (n = 30): induction with thiopentone 4-6 mg kg-1, fentanyl 2 micrograms kg-1, pancuronium 0.03 mg kg-1, and succinylcholine 1 mg kg-1, maintainance with halothane (0.8-1.5%), and N2O in O2 (FiO2 = 0.33). Group two (n = 30): induction with propofol 2-3 mg kg-1, fentanyl 2 micrograms kg-1, pancuronium 0.03 mg kg-1, and succinylcholine 1 mg kg-1, maintainance with propofol 6-10 mg kg-1 h-1, and O2 in N2 (FiO2:0.33). Seven of the patients experienced nausea in each group with group one having higher emetic scores. Six patients in group one vomited compared to none in group two (P < 0.05). The overall incidence of emetic sequelae (nausea or vomiting) was 43% in group one and 23% in group two (P = 0.17). Patients with propofol anaesthesia had lower emetic scores and higher recovery scores compared with those after thiopentone/halothane anaesthesia.
Klockgether-Radke
A
A
Department of Anaesthesiology, Georg August University of Göttingen, Germany.
Piorek
V
V
Crozier
T
T
Kettler
D
D
D000328:Adult; D000368:Aged; D000758:Anesthesia / Q000009:adverse effects; D000777:Anesthetics / Q000009:adverse effects*; D005260:Female; D006221:Halothane / Q000009:adverse effects*; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000209:etiology*; D011183:Postoperative Complications / Q000209:etiology*; D015742:Propofol / Q000009:adverse effects*; D013874:Thiopental / Q000009:adverse effects*; D014839:Vomiting / Q000209:etiology*
D000777:Anesthetics; D013874:Thiopental; D006221:Halothane; D015742:Propofol