Pharmacological studies to examine the source of ATP released by pelvic nerve stimulation in the feline lower urinary tract.
1. Pretreatment with 6-OHDA or bilateral sectioning of the hypogastric nerves decreased the noradrenaline content of lower urinary tract tissue. 2. Pelvic nerve stimulation-induced contractions were not significantly changed by either 6-OHDA pretreatment or bilateral sectioning of the hypogastric nerves. 3. Hypogastric nerve stimulation-induced contractions were significantly attenuated by the pretreatments. 4. Neither ATP- nor acetylcholine-induced contractions were significantly altered by either 6-OHDA or bilateral sectioning of the hypogastric nerves. 5. The data indicate that ATP, released by pelvic nerve stimulation, which induces a bladder contraction, is released from parasympathetic, cholinergic nerve fibres in the pelvic nerve trunks and not sympathetic, nor adrenergic nerve fibres also present in the pelvic nerve trunks.
Theobald
R J
RJ
Department of Pharmacology, Kirksville College of Osteopathic Medicine, MO 6350, USA.
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D005260:Female; D007001:Hypogastric Plexus / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000378:metabolism; D016627:Oxidopamine / Q000494:pharmacology; D013562:Sympathectomy; D001743:Urinary Bladder / Q000187:drug effects / Q000294:innervation / Q000502:physiology; D014551:Urinary Tract / Q000187:drug effects / Q000294:innervation*; D014553:Urinary Tract Physiological Phenomena
D016627:Oxidopamine; D000255:Adenosine Triphosphate; D009638:Norepinephrine