title: Distribution of HLA DQ A1 alleles and genotypes in two Spanish populations (Aragon and Asturias).
abstract: HLA DQ A1 is probably one of the PCR-based genetic marker systems most widely used in actual forensic casework analyses. As accurate data about the distribution of the alleles is one of the most important prerequisites for the application in forensic biology, we studied the allele distribution in two relevant Spanish populations (Aragonese and Asturian). Results were in good agreement with the Hardy-Weinberg law in both Aragonese and Asturian populations. The power of discrimination was 0.92 in the Aragonese and 0.93 in Asturian sample. A test for homogeneity of the HLA DQ A1 population data based on alelle frequency counts for 12 European samples was performed and no significant differences were found (P = 0.831).
authors.affiliation: Department of Legal Medicine, University of Zaragoza, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Martínez-Jarreta
authors.forename: M
authors.initials: M
authors.lastname: Bolea
authors.forename: M
authors.initials: M
authors.lastname: Castellano
authors.forename: R
authors.initials: R
authors.lastname: Hinojal
authors.forename: E
authors.initials: E
authors.lastname: Abecia
mesh_terms: D000483:Alleles; D016002:Discriminant Analysis; D005554:Forensic Medicine; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D006801:Humans; D016133:Polymerase Chain Reaction; D015203:Reproducibility of Results; D013030:Spain
chemical_list: D005819:Genetic Markers; D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen