Ion channels as pharmacologic receptors: the chirality of drug interactions.
Ion channels are pharmacologic receptors and as such exhibit stereoselective interactions with drugs. Ion channels are conformationally mobile transmembrane proteins existing in a number of open and closed states. Drug interactions with these different states may differ quantitatively and qualitatively. Stereoselectivity may not be a constant factor and may change according to channel state as determined by stimulus mode or experimental conditions. Selected examples are cited for Na+ and Ca2+ channels.
Triggle
D J
DJ
School of Pharmacy, State University of New York, Buffalo 14260, USA.
D000818:Animals; D006801:Humans; D007473:Ion Channels / Q000737:chemistry / Q000378:metabolism*; D008968:Molecular Conformation; D011955:Receptors, Drug / Q000737:chemistry / Q000378:metabolism*; D013237:Stereoisomerism
D007473:Ion Channels; D011955:Receptors, Drug