title: Prenatal diagnosis of a stable de novo centric fission: a case report.
abstract: We report on the prenatal diagnosis of a baby with a de novo centromeric fission of chromosome 21. Both fission products were mitotically stable. Follow-up chromosome analysis after birth confirmed the centromere fission. This chromosome fission appears to be without clinical significance for this patient.
authors.affiliation: Mid-Pacific Genetics, Honolulu, HI 96814, USA.
authors.forename: M H
authors.initials: MH
authors.lastname: Bogart
authors.forename: N
authors.initials: N
authors.lastname: Fujita
authors.forename: L
authors.initials: L
authors.lastname: Serles
authors.forename: Y E
authors.initials: YE
authors.lastname: Hsia
mesh_terms: D002503:Centromere; D002869:Chromosome Aberrations; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D011247:Pregnancy; D011296:Prenatal Diagnosis