Neuronal bungarotoxin displaces (125I) alpha-bungarotoxin binding at the neuromuscular junction as well as to the spinal cord during embryogenesis.
Alpha-Bungarotoxin (alpha BTX) administration in ovo prevents motoneuron apoptosis during development. This process may be mediated by alpha BTX-sensitive nicotinic cholinoceptors in the spinal cord, at the neuromuscular junction or at both sites. In order to differentiate between these possibilities, neuronal bungarotoxin binding (NBTX) binding to embryonic muscle and spinal cord was investigated in the chick.
Renshaw
G M
GM
Department of Anatomical Sciences, University of Queensland, St. Lucia, Australia. g.renshaw@mailbox.uq.oz.au
Goldie
R
R
D000818:Animals; D001667:Binding, Competitive; D002038:Bungarotoxins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D002642:Chick Embryo; D005314:Embryonic and Fetal Development; D007457:Iodine Radioisotopes; D009132:Muscles / Q000196:embryology / Q000378:metabolism; D009469:Neuromuscular Junction / Q000196:embryology* / Q000378:metabolism; D009538:Nicotine / Q000494:pharmacology; D013116:Spinal Cord / Q000196:embryology* / Q000378:metabolism
D002038:Bungarotoxins; D007457:Iodine Radioisotopes; D009538:Nicotine; C073712:neuronal bungarotoxin