Pulmonary responses to heparin-protamine complexes: the effects of age and species.
To test the hypothesis that heparin-protamine complexes (H-P complexes) react with pulmonary intravascular macrophages, we studied the difference in the pulmonary reaction to H-P complexes between goats and rabbits and among different-aged goats. The increases in pulmonary arterial pressure (Ppa) and plasma thromboxane levels (Tx) after injection of H-P complexes (1.2 ml/kg) in goats (delta Ppa = 17 +/- 7.0 mmHg, delta Tx = 17.3 +/- 10.1 ng/ml) were significantly greater than in rabbits (delta Ppa = 0.50 +/- 1.0 mmHg, delta Tx = -0.01 +/- 0.17 ng/ml), the increase in Ppa in adult goats (> 150 days old; delta Ppa = 17 +/- 7.0 mmHg) was about sixfold higher than in newborn goats (1-3 days old; delta Ppa = 2.8 +/- 4.0 mmHg), and the increase in Tx in adult goats (delta Tx = 17.3 +/- 10.1 ng/ml) was significantly greater than those in newborn and young (19 days old) goats (delta Tx = 0.69 +/- 0.48 and 3.60 +/- 0.36 ng/ml, respectively). The pulmonary hemodynamic reaction to H-P complexes is consistent with the concept that the H-P complexes react with pulmonary intravascular macrophages.
Horiguchi
T
T
Department of Anesthesia, Akita Kumiai Hospital, Japan.
Enzan
K
K
Kawamura
K
K
Suzuki
M
M
D000375:Aging / Q000473:pathology*; D000818:Animals; D000831:Animals, Newborn; D005260:Female; D006041:Goats; D006439:Hemodynamics / Q000187:drug effects; D008168:Lung / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure; D016676:Macrophages, Alveolar / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D011652:Pulmonary Circulation / Q000187:drug effects; D011817:Rabbits; D013045:Species Specificity; D013929:Thromboxane B2 / Q000494:pharmacology
D013929:Thromboxane B2