Exfoliative dermatitis due to immunologically confirmed carbamazepine hypersensitivity.
A 6-year-old Caucasian girl experienced a generalized erythematous skin rash during carbamazepine therapy. Over the next four days the eruption worsened into erythroderma with fever and generalized lymphadenopathy. Routine laboratory studies revealed increased serum levels of liver enzymes and eosinophilia. Immunologic reactivity to the anticonvulsant carbamazepine and its analogs was investigated both in vivo and in vitro by patch tests and lymphocyte proliferation assays, respectively.
Troost
R J
RJ
Department of Immunology, Erasmus University, Rotterdam, The Netherlands.
Oranje
A P
AP
Lijnen
R L
RL
Benner
R
R
Prens
E P
EP
D000410:Alanine Transaminase / Q000097:blood; D000927:Anticonvulsants / Q000009:adverse effects*; D001219:Aspartate Aminotransferases / Q000097:blood; D002220:Carbamazepine / Q000009:adverse effects* / Q000031:analogs & derivatives; D002648:Child; D003873:Dermatitis, Exfoliative / Q000139:chemically induced*; D003875:Drug Eruptions / Q000209:etiology*; D004342:Drug Hypersensitivity / Q000209:etiology*; D004802:Eosinophilia / Q000139:chemically induced; D005260:Female; D005334:Fever / Q000139:chemically induced; D006801:Humans; D008206:Lymphatic Diseases / Q000139:chemically induced; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D010328:Patch Tests
D000927:Anticonvulsants; D002220:Carbamazepine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase