HLA-B27 and HLA-B73 polymorphism and its role on antigenicity, peptide presentation, and disease susceptibility.
Current ideas on the structure, evolution, and disease association of HLA-B27 antigens are presented, with emphasis on the effect of HLA-B27 polymorphism on T-cell recognition and antigen-presenting properties of these molecules. The molecular relationship between HLA-B27 and HLA-B73, and its implications for a putative pathogenetic role of the later antigen are discussed.
Lopez De Castro
J A
JA
Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Spain.
D016918:Arthritis, Reactive / Q000209:etiology / Q000276:immunology*; D004198:Disease Susceptibility / Q000276:immunology; D015235:HLA-B Antigens / Q000276:immunology*; D015796:HLA-B27 Antigen / Q000276:immunology*; D006801:Humans; D010455:Peptides / Q000032:analysis; D011110:Polymorphism, Genetic / Q000276:immunology; D013167:Spondylitis, Ankylosing / Q000209:etiology / Q000276:immunology*
D015235:HLA-B Antigens; D015796:HLA-B27 Antigen; C088197:HLA-B73 antigen; D010455:Peptides