Synthetic analogues of netropsin and distamycin. II. Synthesis of a carbocyclic analogue of the pyrrolecarboxamide antitumour antibiotics.
The synthesis of a carbocyclic analogue of netropsin (X) in which N-methylpyrrole rings were replaced by 1,3-disubstituted benzene rings was accomplished in eight steps starting from 4-hydroxyazobenzene-3-carboxylic acid.
Bartulewicz
D
D
Department of Organic Chemistry, Medical Academy of Białystok.
Bielawski
K
K
Krajewska
D
D
Rózański
A
A
D000998:Antiviral Agents / Q000138:chemical synthesis*; D001554:Benzene / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D002855:Chromatography, Thin Layer; D004214:Distamycins / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009429:Netropsin / Q000031:analogs & derivatives*; D011758:Pyrroles / Q000737:chemistry
D000998:Antiviral Agents; D004214:Distamycins; D011758:Pyrroles; D009429:Netropsin; C030000:stallimycin; D001554:Benzene