title: Raised level of amniotic endothelin in pregnancies with fetal aneuploidy.
abstract: Amniotic fluid endothelin-1 (ET-1) levels were measured in 38 euploid and in 15 aneuploid pregnancies in the 17th gestational week. Varying distribution of the peptide levels was found in the two groups, with higher values in the pathological cases. Should this finding be confirmed in maternal blood, ET-1 could represent a further analyte to be used in prenatal screening for aneuploidy.
authors.affiliation: Department of Obstetrics and Gynecology, University of Ferrara, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Vesce
authors.forename: A
authors.initials: A
authors.lastname: Farina
authors.forename: G
authors.initials: G
authors.lastname: Jorizzo
authors.forename: C
authors.initials: C
authors.lastname: Tarabbia
authors.forename: O
authors.initials: O
authors.lastname: Calabrese
authors.forename: D
authors.initials: D
authors.lastname: Pelizzola
authors.forename: G
authors.initials: G
authors.lastname: Giovannini
authors.forename: A
authors.initials: A
authors.lastname: Piffanelli
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000378:metabolism*; D000782:Aneuploidy; D019332:Endothelin-1 / Q000378:metabolism*; D005260:Female; D005315:Fetal Diseases / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*
chemical_list: D019332:Endothelin-1