Homobotcinolide: a biologically active natural homolog of botcinolide from Botrytis cinerea.
A novel natural product exhibiting biological activity was isolated from a strain of Botrytis cinerea that had infected raspberry fruit (Rubus ideaus). Liquid fermentation and bioassay-directed fractionation of the organism yielded a compound with molecular formula C22H38O8 that is trivially named homobotcinolide. It significantly inhibited etiolated wheat coleoptile growth. Greenhouse-grown bean, corn, and tobacco plants were also affected by exogenous application of homobotcinolide, severe chlorosis and necrosis being exhibited in corn. The compound is a polyhydroxylated nonalactone esterified with 4-hydroxy-2-decenoic acid.
Cutler
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HG
USDA, ARS, Richard B. Russell Research Center, Athens, Georgia 30613, USA.
Parker
S R
SR
Ross
S A
SA
Crumley
F G
FG
Schreiner
P R
PR
D001681:Biological Assay; D005591:Chemical Fractionation; D003651:Decanoates / Q000302:isolation & purification*; D005285:Fermentation; D007783:Lactones / Q000302:isolation & purification*; D003904:Mitosporic Fungi / Q000737:chemistry*; D015394:Molecular Structure; D010937:Plant Growth Regulators / Q000302:isolation & purification*
D003651:Decanoates; D007783:Lactones; D010937:Plant Growth Regulators; C101236:botcinolide; C101235:homobotcinolide