title: Duplication of 2q31-qter as a sole aberration in a case of non-Hodgkin's lymphoma.
abstract: We report a case of peripheral T-cell lymphoma that was initially found to have the aberrant karyotype 47,XX,t(2;13)(q22;q22),+19. At relapse 2 years later, a malignant clone with the karyotype 46,XX,der(22)t(2;22)(q31;q13) was identified. This rearrangement leads to a duplication of the distal part of the long arm of chromosome 2. We used chromosome-specific painting libraries and multicolor fluorescence in situ hybridization, as a complement to banding analysis, to resolve the karyotype.
authors.affiliation: Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Bajalica-Lagercrantz
authors.forename: N
authors.initials: N
authors.lastname: Tingaard Pedersen
authors.forename: A G
authors.initials: AG
authors.lastname: Sørensen
authors.forename: M
authors.initials: M
authors.lastname: Nordenskjöld
mesh_terms: D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002882:Chromosomes, Human, Pair 13; D002889:Chromosomes, Human, Pair 2; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D016399:Lymphoma, T-Cell / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D014178:Translocation, Genetic