title: Time course of exercise capacity, skeletal and respiratory muscle performance after heart-lung transplantation.
abstract: Recipients of heart-lung transplantation (HLT) show reduced exercise capacity due to several pre- and postsurgical factors. The aim of this study was to evaluate the time course of exercise capacity, and skeletal and respiratory muscle performance in 11 patients (5 females and 6 males; age (mean +/- SD) 38 +/- 13 yrs) undergoing HLT. All of the patients were admitted to our institution for a rehabilitation programme after surgery, and were followed-up for 18 months. On admission, at discharge after an in-patient rehabilitation programme, and every 6 months, patients underwent evaluation of: lung function values; incremental treadmill exercise, 6 min walking distance (6-MWD); maximal inspiratory and expiratory pressures (MIP and MEP, respectively); and peak torque of isokinetic contraction of leg flexor and extensor muscles (IFX and IEX, respectively). On admission, patients had: reduced lung volumes as assessed by vital capacity (VC) (60 +/- 15% of predicted); reduced exercise capacity as assessed by peak oxygen consumption (V'O2,peak) (40 +/- 12% pred); reduced skeletal and respiratory muscle performance as assessed by IEX, IFX (48 +/- 16 and 28 +/- 12 Newton-metres (N x m), respectively) and by MIP and MEP (54 +/- 21 and 58 +/- 19 cmH2O, respectively). Ten patients completed the rehabilitation programme. At discharge, no significant change in dynamic and static lung volumes was observed. However, nonsignificant increases in MIP, MEP, IEX, IFX, 6-MWD and V'O2,peak were recorded. After 6 and 12 months, indices of skeletal and respiratory muscle function and V'O2, peak improved further, but still remained lower than normal values. We conclude that in patients with heart-lung transplantation, skeletal and respiratory muscle function and exercise performance are reduced after surgery, that they may improve with time but are still less than normal after 18 months.
authors.affiliation: Salvatore Maugeri Foundation IRCCS, Medical Center, Montescano, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Ambrosino
authors.forename: C
authors.initials: C
authors.lastname: Bruschi
authors.forename: G
authors.initials: G
authors.lastname: Callegari
authors.forename: S
authors.initials: S
authors.lastname: Baiocchi
authors.forename: G
authors.initials: G
authors.lastname: Felicetti
authors.forename: C
authors.initials: C
authors.lastname: Fracchia
authors.forename: C
authors.initials: C
authors.lastname: Rampulla
mesh_terms: D000328:Adult; D005080:Exercise Test; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D016041:Heart-Lung Transplantation / Q000502:physiology* / Q000534:rehabilitation; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology*; D012129:Respiratory Function Tests; D012132:Respiratory Muscles / Q000502:physiology*; D013997:Time Factors