Peripheral osteopenia in adult patients with insulin-dependent diabetes mellitus.
Alterations in bone metabolism in diabetes mellitus is a topic of special interest. Bone blood flow is increased in the distal limb of diabetic patients, which is believed to increase osteoclastic activity. We measure bone mineral density using dual-photon absorptiometry in the distal lower limb, the femoral neck, and the lumbar spine in 41 IDDM patients and in 30 control persons. In the diabetic group there was a 10% reduction of bone mineral density in the femoral neck (p < 0.01) and a 12% reduction in the distal limb (p < 0.001) compared with the control group. No significant difference was found in the lumbar spine (p = 0.22). Our data yield incidence for peripheral osteopenia in IDDM-patients, independent of any systemic bone disease such as osteoporosis. A link between decreased bone mineral density and diabetic neuropathy has been observed for the femoral neck (p < 0.001), but not for the distal limb or axial skeleton. Whether there is a common aetiological link or a casual connection between diabetic neuropathy and bone mineral density has still to be determined.
Forst
T
T
Department of Endocrinology and Internal Medicine, University Hospital Mainz, Germany.
Pfützner
A
A
Kann
P
P
Schehler
B
B
Lobmann
R
R
Schäfer
H
H
Andreas
J
J
Bockisch
A
A
Beyer
J
J
D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D000419:Albuminuria; D015992:Body Mass Index; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003404:Creatinine / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000503:physiopathology*; D005260:Female; D005269:Femur; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007866:Leg; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012044:Regression Analysis
D003404:Creatinine; D006442:Glycated Hemoglobin