Seven days of exercise increase GLUT-4 protein content in human skeletal muscle.
Insulin-responsive glucose transporter (GLUT-4) content increases by 1.8-fold in skeletal muscle with 14 wk of exercise training [Houmard et al. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E896-E901, 1993]. The purpose of this study was to determine whether more short-term training (7 days) increases GLUT-4 protein content in human skeletal muscle. Seven sedentary men [25.0 +/- 1.1 (SE) yr, 44.1 +/- 2.2 ml.kg-1.min-1 maximal O2 uptake, 14.9 +/- 2.1% body fat] were examined before and after 7 days of cycle ergometer training (1 h/day, 76 +/- 2% maximal heart rate). Needle biopsy samples from the vastus lateralis were used to determine GLUT-4 protein content. Muscle GLUT-4 increased (P < 0.05) by an average of 2.8 +/- 0.5-fold with 7 days of training. GLUT-4 content in skeletal muscle thus increases substantially with short-term exercise training.
Houmard
J A
JA
Department of Biochemistry, East Carolina University, Greenville, North Carolina 27858, USA.
Hickey
M S
MS
Tyndall
G L
GL
Gavigan
K E
KE
Dohm
G L
GL
D015153:Blotting, Western; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D009004:Monosaccharide Transport Proteins / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D013997:Time Factors
D009004:Monosaccharide Transport Proteins