Changing concepts in the management of endometrial cancer.
Endometrial carcinoma was a clinically staged disease until the late 1980s, at which point, staging changed to a surgicopathologically defined system. This change in staging, in turn, altered the clinical management of this cancer. Based on surgicopathologic prognostic information, adjuvant radiation evolved from a preoperative treatment for all patients to a postoperative treatment for selected patients. The role of radiation in surgically staged patients is currently being evaluated. More innovative systemic strategies are needed for patients with advanced or recurrent disease.
Karasek
K
K
University of Pittsburgh Magee-Womens Hospital Department of Radiation Oncology, Pittsburgh, Pennsylvania, USA.
Faul
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C
D000970:Antineoplastic Agents / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D016889:Endometrial Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D018579:Patient Selection; D011182:Postoperative Care; D011300:Preoperative Care; D011379:Prognosis; D018714:Radiotherapy, Adjuvant
D000970:Antineoplastic Agents