Met-11 of HLA class II DP alpha 1 first domain associated with onchocerciasis.
Human infection with the pathogenic tissue nematode Onchocerca volvulus may result in a spectrum of clinical manifestations or in a putatively immune condition. A methionine at amino acid position 11 of the HLA class II DP alpha 1 chain correlates with the occurring disease after infection (relative risk 3.3). The alternative alanine at position 11 is, conversely, associated with protection from disease ("relative protection' 3.5). DPA1*0301 is associated with the localized form of disease after O. volvulus infection.
Meyer
C G
CG
Department of Molecular Biology, Institute for Tropical Medicine, Berlin, Germany.
Schnittger
L
L
May
J
J
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004198:Disease Susceptibility; D000939:Epitopes / Q000235:genetics / Q000276:immunology; D008040:Genetic Linkage / Q000235:genetics*; D006682:HLA-DP Antigens / Q000235:genetics* / Q000276:immunology; D059867:HLA-DP alpha-Chains; D059868:HLA-DP beta-Chains; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008715:Methionine / Q000032:analysis*; D008969:Molecular Sequence Data; D017181:Onchocerca volvulus / Q000472:pathogenicity; D009855:Onchocerciasis / Q000235:genetics* / Q000503:physiopathology; D012307:Risk Factors
D000939:Epitopes; D006682:HLA-DP Antigens; D059867:HLA-DP alpha-Chains; D059868:HLA-DP beta-Chains; C071172:HLA-DPA1 antigen; C071170:HLA-DPB1 antigen; D008715:Methionine