title: Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain.
abstract: Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) support the viability and function of many types of neurons, and are likely mediators of activity-dependent changes in the CNS. We examined BDNF and NGF mRNA levels in several brain areas of adult male rats following 0, 2, 4, or 7 nights with ad libitum access to running wheels. BDNF mRNA was significantly increased in several brain areas, most notably in the hippocampus and caudal 1/3 of cerebral cortex following 2, 4, and 7 nights with exercise. Significant elevations in BDNF mRNA were localized in Ammon's horn areas 1 (CA1) and 4 (CA4) of the hippocampus, and layers II-III of the caudal neocortex and retrosplenial cortex. NGF mRNA was also significantly elevated in the hippocampus and caudal 1/3 of the cortex, affecting primarily the dentate gyrus granular layer (DG) and CA4 of the hippocampus and layers II-III in caudal neocortex.
authors.affiliation: Department of Psychobiology, University of California at Irvine 92717-4540, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Neeper
authors.forename: F
authors.initials: F
authors.lastname: Gómez-Pinilla
authors.forename: J
authors.initials: J
authors.lastname: Choi
authors.forename: C W
authors.initials: CW
authors.lastname: Cotman
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000378:metabolism*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009414:Nerve Growth Factors / Q000235:genetics*; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D012333:RNA, Messenger