title: Post-operative intravenous continuous analgesia: comparison of buprenorphine, fentanyl and nalbuphine.
abstract: Continuous intravenous infusions of fentanyl, buprenorphine or nalbuphine were investigated to provide pain relief for patients after major abdominal surgery. Buprenorphine (n = 23) was given as a loading dose of 5 micrograms kg-1 and infused at 0.8 micrograms kg-1 h-1. Fentanyl (n = 20) was given as a loading dose of 2 micrograms kg-1 and infused at 0.7 micrograms kg-1 h-1. Nalbuphine (n = 21) was given as a loading dose of 200 micrograms kg-1 and infused at 80 micrograms kg-1 h-1. The infusion rate was increased when analgesia was inadequate, and decreased if respiratory depression occurred. Mean doses were respectively 0.74 +/- 0.15 microgram kg-1 h-1 buprenorphine, 0.68 +/- 0.18 microgram kg-1 h-1 fentanyl, 83 +/- 21 micrograms kg-1 h-1 nalbuphine. Titration of continuous intravenous infusion of buprenorphine and fentanyl provided better analgesia than nalbuphine with smaller doses than those reported in similar studies allowing spontaneous breathing.
authors.affiliation: Service d'Anesthésie et de Réanimation Chirurgicale, Hôtel-Dieu, Nantes, France.
authors.forename: C
authors.initials: C
authors.lastname: Lejus
authors.forename: Y
authors.initials: Y
authors.lastname: Blanloeil
authors.forename: T
authors.initials: T
authors.lastname: François
authors.forename: S
authors.initials: S
authors.lastname: Testa
authors.forename: P
authors.initials: P
authors.lastname: Michel
authors.forename: B
authors.initials: B
authors.lastname: Dixneuf
mesh_terms: D000328:Adult; D000368:Aged; D000698:Analgesia; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D002047:Buprenorphine / Q000008:administration & dosage*; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009266:Nalbuphine / Q000008:administration & dosage*; D010149:Postoperative Pain / Q000188:drug therapy*; D011446:Prospective Studies
chemical_list: D000701:Analgesics, Opioid; D002047:Buprenorphine; D009266:Nalbuphine; D005283:Fentanyl