title: Redistribution on I-123 IMP SPECT in children and adolescents with partial seizures.
abstract: To evaluate the redistribution phenomenon on delayed I-123 IMP SPECT images of children and adolescents with partial seizures, 25 patients were selected and investigated in the interictal state. Early and delayed SPECT were performed 15-20 minutes and 5 hours, respectively, after I-123 IMP injection. Redistribution patterns were classified into three groups: 1) redistribution (RD) (-) group (n = 5), in which a low-uptake area on the early image persisted or was enlarged on the delayed image, 2) RD (+) group (n = 14), in which a low-uptake area on the early image changed to normal distribution on the delayed image, and 3) marked redistribution (MRD) (+) group (n = 6), In which a low-uptake area on the early image changed to a high uptake area on the delayed image. Among the patients who were followed for at least 12 months after the SPECT scans, the short-term clinical outcome tended to be good in the RD (+) group, intermediate in the MRD (+) group, and poor in the RD (-) group. These results of our preliminary comparative study indicate that the redistribution pattern of I-123 IMP may be related to the clinical aspects in patients with partial seizures and that it may play an important role in predicting their short-term clinical outcome.
authors.affiliation: Department of Pediatrics, Niigata University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: I
authors.initials: I
authors.lastname: Odano
authors.forename: N
authors.initials: N
authors.lastname: Takahashi
mesh_terms: D000293:Adolescent; D000662:Amphetamines; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D002648:Child; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000000981:diagnostic imaging*; D017029:Epilepsy, Complex Partial / Q000175:diagnosis / Q000000981:diagnostic imaging; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008279:Magnetic Resonance Imaging; D008297:Male; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine