title: Synthesis and structure-DNA binding relationship analysis of DNA triple-helix specific intercalators.
abstract: 4-[N-(Aminoalkyl)amino]-2-arylquinolines with conformational freedom around positions 2 and 4 of the quinoline stabilize strongly poly(dT.dA.dT) (triplex DNA) and bind weakly to poly-(dA.dT) (duplex DNA). Basicity of N1 of the quinoline parallels the interaction strength of these compounds with the triple-helical DNA structure suggesting that N1 of the quinoline is protonated in the complex with the DNA triplex. The experimental results support the interaction model suggested previously.
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta 30303, USA.
authors.forename: L
authors.initials: L
authors.lastname: Strekowski
authors.forename: Y
authors.initials: Y
authors.lastname: Gulevich
authors.forename: T C
authors.initials: TC
authors.lastname: Baranowski
authors.forename: A N
authors.initials: AN
authors.lastname: Parker
authors.forename: A S
authors.initials: AS
authors.lastname: Kiselyov
authors.forename: S Y
authors.initials: SY
authors.lastname: Lin
authors.forename: F A
authors.initials: FA
authors.lastname: Tanious
authors.forename: W D
authors.initials: WD
authors.lastname: Wilson
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D007364:Intercalating Agents / Q000138:chemical synthesis* / Q000378:metabolism*; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D011071:Poly T / Q000378:metabolism; D011067:Poly dA-dT / Q000378:metabolism; D011804:Quinolines / Q000737:chemistry* / Q000378:metabolism; D013053:Spectrophotometry; D013329:Structure-Activity Relationship; D013816:Thermodynamics
chemical_list: D007364:Intercalating Agents; D011804:Quinolines; D011071:Poly T; D011067:Poly dA-dT; D004247:DNA