title: Low dose hydrochlorothiazide (12.5 to 25 mg daily) as monotherapy in black patients with mild to moderate hypertension. Assessment by ambulatory blood pressure monitoring.
abstract: The efficacy of low dose (12.5 to 25 mg daily) hydrochlorothiazide (HCTZ) was evaluated by ambulatory blood pressure monitoring (ABPM) in 19 mild to moderate hypertensive (mean daytime 12-h diastolic BP > or = 90 mm Hg and < 115 mm Hg) South African black patients. After a 3-week placebo run-in period, HCTZ was administered for 8 weeks as monotherapy. The mean daytime ABPM was reduced from 159 +/- 13/105 +/- 6 to 145 +/- 11/97 +/- 10 mm Hg (P < .005). Only 6/19 (32%) patients achieved BP control. The 24-h BP load fell from 69% at baseline, to 53% with 12.5 mg HCTZ and to 47% with 25 mg HCTZ daily. There were no side effects but the increase of HCTZ to 25 mg daily was followed by adverse changes (P < .05) in serum potassium levels. It is concluded that low dose of HCTZ monotherapy has only a moderate effect on the BP control and 24-h BP load while the higher 25 mg dose is associated with significant decrease in serum potassium level.
authors.affiliation: Division of Cardiology, Barawanath Hospital, Johannesburg, South Africa.
authors.forename: J
authors.initials: J
authors.lastname: Skoularigis
authors.forename: V
authors.initials: V
authors.lastname: Strugo
authors.forename: A
authors.initials: A
authors.lastname: Chopamba
authors.forename: S
authors.initials: S
authors.lastname: Setekge
authors.forename: P
authors.initials: P
authors.lastname: Sareli
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D044383:Black People; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage* / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy* / Q000208:ethnology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D000959:Antihypertensive Agents; D006852:Hydrochlorothiazide