title: SOX genes: architects of development.
abstract: Development in higher organisms involves complex genetic regulation at the molecular level. The emerging picture of development control includes several families of master regulatory genes which can affect the expression of down-stream target genes in developmental cascade pathways. One new family of such development regulators is the SOX gene family. The SOX genes are named for a shared motif called the SRY box a region homologous to the DNA-binding domain of SRY, the mammalian sex determining gene. Like SRY, SOX genes play important roles in chordate development. At least a dozen human SOX genes have been identified and partially characterized (Tables 1 and 2). Mutations in SOX9 have recently been linked to campomelic dysplasia and autosomal sex reversal, and other SOX genes may also be associated with human disease.
authors.affiliation: Ocular Genetics Research Group, University of Alberta, Edmonton, Canada.
authors.forename: H M
authors.initials: HM
authors.lastname: Prior
authors.forename: M A
authors.initials: MA
authors.lastname: Walter
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002874:Chromosome Mapping; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics; D005786:Gene Expression Regulation; D005801:Genes, Homeobox; D006609:High Mobility Group Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics; D055748:SOXB1 Transcription Factors; D055751:SOXC Transcription Factors; D055755:SOXD Transcription Factors; D012732:Sex Determination Analysis; D051876:Sex-Determining Region Y Protein; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology
chemical_list: D004268:DNA-Binding Proteins; D006609:High Mobility Group Proteins; D009687:Nuclear Proteins; C097473:SOX11 protein, human; C527785:SOX3 protein, human; C490301:SOX5 protein, human; C486270:SOX6 protein, human; D055748:SOXB1 Transcription Factors; D055751:SOXC Transcription Factors; D055755:SOXD Transcription Factors; C497745:SRY protein, human; D051876:Sex-Determining Region Y Protein; C490793:Sox11 protein, mouse; C527786:Sox3 protein, mouse; D014157:Transcription Factors