Nortriptyline-induced hepatic failure.
We report a case of hepatic injury after treatment with nortriptyline in a therapeutic dose. There were symptoms of hepatitis and increased prothrombin time, serum alanine aminotransferase and alkaline phosphatases. The patient recovered after discontinuation of the drug.
Pedersen
A M
AM
Department of Medicine, Sundby Hospital, Copenhagen, Denmark.
Enevoldsen
H K
HK
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D005260:Female; D006801:Humans; D017093:Liver Failure / Q000139:chemically induced* / Q000201:enzymology; D008875:Middle Aged; D009661:Nortriptyline / Q000009:adverse effects*; D011517:Prothrombin Time
D000929:Antidepressive Agents, Tricyclic; D009661:Nortriptyline; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase