Gastric malt lymphoma with crystalline immunoglobulin inclusions and secondary immunoblastic lymphoma in a cervical lymph node.
A case of gastric B cell lymphoma of the mucosa-associated lymphoid tissue (MALT) with crystalline immunoglobulin inclusions in monotypic plasma cells is reported, which initially presented as a secondary immunoblastic lymphoma in a cervical lymph node. The low-grade MALT lymphoma was diagnosed 14 months after detection of the nodal high-grade lymphoma, but rare crystal-containing plasma cells of identical immunoglobulin isotype found in the immunoblastic lymphoma retrospectively confirmed a common clonal origin. The diagnostic significance of crystalline immunoglobulin inclusions and the unusual initial presentation of MALT lymphoma as a secondary high-grade lymphoma at a distant nodal site are discussed.
Fend
F
F
Department of Pathology, University of Innsbruck, Austria.
Gabl
C
C
Hittmair
A
A
Greil
R
R
Feichtinger
H
H
D000368:Aged; D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis*; D002479:Inclusion Bodies / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D016393:Lymphoma, B-Cell / Q000473:pathology* / Q000601:surgery; D018442:Lymphoma, B-Cell, Marginal Zone / Q000473:pathology*; D008297:Male; D009333:Neck; D010950:Plasma Cells / Q000473:pathology; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery; D013276:Stomach Ulcer / Q000473:pathology
D007136:Immunoglobulins