title: Haemorrhagic shock and encephalopathy associated with rotavirus infection.
abstract: We report on a 21-month-old girl with a haemorrhagic shock and encephalopathy who survived. Rotavirus genomic ribonucleic acid was detected by reverse transcription polymerase chain reaction in stool, blood and cerebrospinal fluid. Serum antibody titres of the rotavirus were also high. Plasmapheresis had a stabilizing effect on the course of the disease. This case indicates that rotavirus infection may play an important role in the devastating cascade that occurs in some patients with this syndrome. The findings suggest that extensive investigation for rotavirus infection, particularly infection of the central nervous system, should be carried out in patients with haemorrhagic shock and encephalopathy.
authors.affiliation: Division of Neurology, Chiba Children's Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Makino
authors.forename: Y
authors.initials: Y
authors.lastname: Tanabe
authors.forename: K
authors.initials: K
authors.lastname: Shinozaki
authors.forename: S
authors.initials: S
authors.lastname: Matsuno
authors.forename: T
authors.initials: T
authors.lastname: Furuya
mesh_terms: D001927:Brain Diseases / Q000821:virology*; D005260:Female; D006801:Humans; D007223:Infant; D010956:Plasmapheresis; D016133:Polymerase Chain Reaction / Q000379:methods; D012367:RNA, Viral / Q000032:analysis; D012401:Rotavirus / Q000235:genetics; D012400:Rotavirus Infections / Q000628:therapy; D012771:Shock, Hemorrhagic / Q000628:therapy / Q000821:virology*
chemical_list: D012367:RNA, Viral