A molecular model for human Big-Endothelin-1 (Big ET-1).
A molecular model has been developed for human Big Endothelin-1, which is the immediate precursor to the potent vasoconstrictor polypeptide endothelin-1 and the target of the highly specific endothelin converting enzyme. This model is produced by a threading algorithm protocol and is consistent with all the currently available structural and biochemical data for this molecule.
Peto
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Department of Crystallography, Birkbeck College, University of London, UK.
Corder
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Janes
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Wallace
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BA
D000465:Algorithms; D004220:Disulfides / Q000737:chemistry; D010450:Endopeptidases / Q000378:metabolism; D019332:Endothelin-1 / Q000494:pharmacology; D016232:Endothelins / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D011498:Protein Precursors / Q000737:chemistry*; D017433:Protein Structure, Secondary
D004220:Disulfides; D019332:Endothelin-1; D016232:Endothelins; D011498:Protein Precursors; D010450:Endopeptidases