A new intronic polymorphism in the C7 gene 36 bp from the common expressed C7 M/N polymorphism.
We report a new polymorphism in the complement C7 gene that results from an A-C transversion in intron 12, 27 bp upstream of exon 13 (C712.-27) and 36 bp upstream of the point mutation that underlies the C7 M/N antigenic polymorphism. The C7 12.-27 polymorphism subdivides C7 M haplotypes, but not C7 N. It also sheds light on the evolution of the various types of deficiency genes at the adjacent C6 locus.
Fernie
B A
BA
Molecular Immunopathology Unit, MRC Centre, Cambridge, U.K.
Würzner
R
R
Orren
A
A
Hobart
M
M
D001483:Base Sequence; D002648:Child; D003184:Complement C7 / Q000172:deficiency / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D007438:Introns / Q000235:genetics*; D008969:Molecular Sequence Data; D017354:Point Mutation / Q000235:genetics; D011110:Polymorphism, Genetic
D003184:Complement C7