In vitro studies of the loss of antibacterial activity of oxytetracycline in presence of Ca(II) or Mg(II) ions.
The results of a comparative study, which evaluated the in vitro effect on the antibacterial activity of oxytetracycline (OTC, CAS 79-57-2) in presence of Ca(II)/Mg(II) ions suggest that susceptibility of Staphylococcus aureus, Bacillus pumilis and Bacillus subtilis to OTC is reduced in presence of Ca(II)/Mg(II) ions. As the ratio of concentration of Ca(II)/Mg(II) to OTC was increased, antibacterial activity of OTC declined. In addition to the difference observed between the antibacterial effect of pure OTC and its Ca(II)/Mg(II) complexes, it was found that decline in antibacterial activity is greater for Mg(II)-OTC complex than Ca(II)-OTC complex for the same concentration of Ca(II)/Mg(II) ions.
Naz
S
S
Department of Chemistry, University of Karachi, Pakistan.
Khan
K A
KA
Zubairi
S A
SA
D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000494:pharmacology; D001407:Bacillus / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects*; D002118:Calcium / Q000737:chemistry / Q000494:pharmacology*; D008274:Magnesium / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010118:Oxytetracycline / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D008274:Magnesium; D002118:Calcium; D010118:Oxytetracycline