[Immunomodulating action of antibiotics in health and in staphylococcal infection].
Benzylpenicillin, streptomycin and gentamicin injected to the mice with Staphylococcus infection increased the immunosuppression induced by the staphylococci. The highest immunosuppressing action was induced by benzylpenicillin. Red blood cells of healthy and especially infected animals showed in case of the allogenic transfer marked immunosuppressing properties. Injection of syngenic red blood cells extracorporeally treated with the antibiotics stimulated the immune response to SRBC in the mice but did not influence the response induced by LPS of Salmonella typhi. The red blood cells incubated in the presence of gentamicin (5000 micrograms) for 1 hour had the most pronounced immunostimulating properties. Benzylpenicillin and streptomycin extracorporal treatment of the red blood cells of the animals infected with staphylococci did not induce immunomodulating properties in them whereas the incubation in the presence of gentamicin resulted in the development of slightly pronounced immunostimulating properties.
Siplivaia
L E
LE
Prokopenko
L G
LG
Lazarev
A I
AI
Shevtsova
E M
EM
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000917:Antibody Formation / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects*; D005839:Gentamicins / Q000627:therapeutic use; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010400:Penicillin G / Q000627:therapeutic use; D010406:Penicillins / Q000627:therapeutic use; D012016:Reference Values; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013307:Streptomycin / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010406:Penicillins; D010400:Penicillin G; D013307:Streptomycin