Molecular mechanisms of action of bacterial exotoxins.
Toxins are one of the inventive strategies that bacteria have developed in order to survive. As virulence factors, they play a major role in the pathogenesis of infectious diseases. Recent discoveries have once more highlighted the effectiveness of these precisely adjusted bacterial weapons. Furthermore, toxins have become an invaluable tool in the investigation of fundamental cell processes, including regulation of cellular functions by various G proteins, cytoskeletal dynamics and neural transmission. In this review, the bacterial toxins are presented in a rational classification based on the molecular mechanisms of action.
Balfanz
J
J
Institut für Medizinische Mikrobiologie und Virologie, Klinikum der Christian-Albrechts-Universität, Kiel, Germany.
Rautenberg
P
P
Ullmann
U
U
D000818:Animals; D001419:Bacteria / Q000378:metabolism*; D003603:Cytotoxins / Q000378:metabolism; D005098:Exotoxins / Q000378:metabolism*; D006801:Humans; D011956:Receptors, Cell Surface / Q000378:metabolism
D003603:Cytotoxins; D005098:Exotoxins; D011956:Receptors, Cell Surface