title: Cytotoxic quinolines (part 1). Azolylalkyloxy quinolines and 1-azolylalkyl-4(1H)-quinolones.
abstract: A series of 4-azolylalkyloxyquinolines and 1-azolylalkyl-4(1H)-quinolones has been synthesized and evaluated for cytotoxicity against various cancer cell lines. 1-Phenyl-1,2,3-triazole and 1-methylpyrazole were found to be the most effective azoles. The length of the alkyl chain was critical, with 8 to 10 carbon atoms being optimal. Several of the compounds were found to be very cytotoxic in vitro towards various cancer cells. Compounds 9o, 10k, and 10r were evaluated in vivo, but were ineffective and exhibited acute general toxicity at higher dosages.
authors.affiliation: SynPhar Laboratories Inc., Edmonton Alberto, Canada.
authors.forename: M D
authors.initials: MD
authors.lastname: Abel
authors.forename: C M
authors.initials: CM
authors.lastname: Ha
authors.forename: H T
authors.initials: HT
authors.lastname: Luu
authors.forename: R G
authors.initials: RG
authors.lastname: Micetich
authors.forename: D Q
authors.initials: DQ
authors.lastname: Nguyen
authors.forename: M
authors.initials: M
authors.lastname: Nukatsuka
authors.forename: A B
authors.initials: AB
authors.lastname: Oreski
authors.forename: M L
authors.initials: ML
authors.lastname: Tempest
authors.forename: M
authors.initials: M
authors.lastname: Daneshtalab
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D001391:Azo Compounds / Q000737:chemistry*; D004247:DNA / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015125:Oxyquinoline / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D001391:Azo Compounds; D011804:Quinolines; D015125:Oxyquinoline; D004247:DNA