Effect of L-dopa on visual evoked potentials and neuropsychological tests in adult phenylketonuria patients.
Eight adult, untreated patients with classical phenylketonuria received L-dopa and a decarboxylase inhibitor for 2 weeks. No effect of L-dopa therapy on choice reaction time tasks, sustained attention, frontal lobal function as well as latencies of visual evoked potentials was found. The results raise the question if adult patients with phenylketonuria really suffer from functional dopamine deficiency.
Ullrich
K
K
University Childrens Hospital, Münster, Germany.
Weglage
J
J
Oberwittler
C
C
Pietsch
M
M
Fünders
B
B
von Eckardstein
H
H
Colombo
J P
JP
D000328:Adult; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D006801:Humans; D007980:Levodopa / Q000494:pharmacology* / Q000627:therapeutic use; D009483:Neuropsychological Tests; D010649:Phenylalanine / Q000097:blood; D010661:Phenylketonurias / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D011930:Reaction Time / Q000187:drug effects; D016896:Treatment Outcome
D007980:Levodopa; D010649:Phenylalanine