Syntheses and immunological effects of thymic humoral factor-gamma 2 and its Phe7-substituted analogues.
Thymic humoral factor-gamma 2 and five analogues modified at position 7 with various phenylalanine derivatives were synthesized by a solid-phase method. The synthetic peptides were tested for their effects on the impaired blastogenic response of phytohemagglutinin-stimulated T lymphocytes of uremic patients with infectious diseases. The synthetic thymic humoral factor-gamma 2 enhanced the blastogenic response of T lymphocytes in the blood of the 2 patients tested. Of the synthetic peptides, [Phe(4F)7]thymic humoral factor-gamma 2 exhibited the most potent effect.
Abiko
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Kidney Research Laboratory, Sendai, Japan.
Sekino
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D000595:Amino Acid Sequence; D003141:Communicable Diseases / Q000188:drug therapy / Q000276:immunology; D005470:Fluorometry; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects* / Q000276:immunology; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D010835:Phytohemagglutinins / Q000633:toxicity; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D013936:Thymidine / Q000378:metabolism; D013951:Thymus Hormones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D014511:Uremia / Q000276:immunology / Q000473:pathology
D009842:Oligopeptides; D010835:Phytohemagglutinins; D013951:Thymus Hormones; C064563:thymic humoral factor gamma 2; D013936:Thymidine