Sodium hyaluronate as a tool in strabismus surgery in rabbits.
OBJECTIVE
The authors tested whether coating tissue with sodium hyaluronate (Na-HA) reduced postoperative adhesions and accelerated the healing process in strabismus surgery.


METHODS
The surgical technique was tested during recession and resection operations performed on 30 rabbits and was compared with the use of NaCl 0.9%. Clinical, biomicroscopic examinations were performed on postoperative days 1, 2, 7, and 30 and histopathologic examinations were performed on postoperative days 2, 7, and 30.


RESULTS
Clinically, there were no statistically significant differences between the study group and the control group. Also, there were no statistically significant differences between the two groups for most of the histopathologic criteria; however, new vessel formation was smaller with Na-HA than without it. Statistical significance was defined as P < .05.


CONCLUSIONS
The authors found no significant positive effect of Na-HA on postoperative healing in rabbits.
Fulga
V
V
Departments of Ophthalmology, Hasharon Hospital, Golda Medical Center, Rehovot, Israel.
Koren
R
R
Ezov
N
N
Gal
R
R
Nimrod
A
A
Savir
H
H
D000818:Animals; D005260:Female; D005500:Follow-Up Studies; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D009801:Oculomotor Muscles / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications / Q000473:pathology / Q000517:prevention & control; D011817:Rabbits; D013285:Strabismus / Q000473:pathology / Q000601:surgery*; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control; D014945:Wound Healing / Q000187:drug effects
D006820:Hyaluronic Acid