Divergent signal transduction pathways and effects on natural killer cell functions induced by interaction of Fc receptors with physiologic ligands or antireceptor antibodies.
Natural killer (NK) cells express receptors that bind to the Fc portion of immunoglobulin molecules (FcR), and their function can potentially be modulated positively or negatively by such receptor:ligand interactions. This review discusses recent developments in the understanding of expression of various forms and isoforms of FcRs by NK cells, and the sequelae of binding of physiologic ligands. Particular attention is paid to the significance of FcR:Ig interactions in both activating and inactivating NK cells under various conditions.
Sulica
A
A
University of Pittsburgh Cancer Institute, Pennsylvania, USA.
Chambers
W H
WH
Manciulea
M
M
Metes
D
D
Corey
S
S
Rabinowich
H
H
Whiteside
T L
TL
Herberman
R B
RB
D000818:Animals; D000911:Antibodies, Monoclonal / Q000502:physiology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008024:Ligands; D008213:Lymphocyte Activation; D011485:Protein Binding / Q000276:immunology; D011961:Receptors, Fc / Q000276:immunology* / Q000502:physiology; D015398:Signal Transduction / Q000276:immunology*
D000911:Antibodies, Monoclonal; D008024:Ligands; D011961:Receptors, Fc