title: Distribution of calcitonin gene-related peptide immunoreactivity in vestibular efferent neurons of the chinchilla.
abstract: The distribution of calcitonin gene-related peptide immunoreactivity (CGRPi) within efferent vestibular neurons in the chinchilla was investigated using fluorescent retrograde labeling combined with immunohistochemistry. Efferent vestibular neurons were found bilaterally in clusters: dorsolateral (group E1) and medial (group E2) to the genu of CN VII, as well as ventromedial to the descending CN VII fibers in the parvicellular reticular formation (PCR). The percentage of retrogradely labeled cells containing CGRPi was 77.1 +/- 5.7 for group E1 neurons, 90.3 +/- 3.8 in the E2 region. Among the PCR efferents more then half of the neurons (61.4 +/- 19.9%) expressed CGRP peptide or message. The wide distribution of CGRP among vestibular efferent neurons suggests that CGRP plays an important role in vestibular efferent function. In addition, the differential distribution among the groups of vestibular efferent neurons suggests that efferent modulation of vestibular function is different between the E cell group efferent neurons and the PCR efferent neurons.
authors.affiliation: Goodhill Ear Center, Division of Head and Neck Surgery, UCLA School of Medicine 90095-1624, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Marco
authors.forename: L F
authors.initials: LF
authors.lastname: Hoffman
authors.forename: P A
authors.initials: PA
authors.lastname: Wackym
authors.forename: P E
authors.initials: PE
authors.lastname: Micevych
authors.forename: P
authors.initials: P
authors.lastname: Popper
mesh_terms: D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000235:genetics / Q000378:metabolism*; D002682:Chinchilla; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D009476:Neurons, Efferent / Q000166:cytology / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D016707:Tissue Fixation; D014722:Vestibule, Labyrinth / Q000166:cytology / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D015740:Calcitonin Gene-Related Peptide