title: Low-density lipoprotein-apheresis in two patients with extremely elevated lipoprotein (a) levels.
abstract: Two male caucasian patients (36 and 42 years old) with heterozygous familial hypercholesterolemia and extremely elevated lipoprotein Lp(a) concentrations, resistant to diet and lipid-lowering drugs, were treated with low-density lipoprotein (LDL)-apheresis for 55 months (liposorber system, Kaneka, Japan) and 15 months (immunoadsorption system, special Lp(a) columns, Lipopak, Pocard, Russia). Lp(a) dropped on average by 50%, total cholesterol by 27%, LDL-cholesterol by 42%, triglycerides by 43%, and the fibrinogen concentration by 16%.
authors.affiliation: University of Saarland, Homburg/Saar, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Bambauer
authors.forename: R
authors.initials: R
authors.lastname: Schiel
authors.forename: J
authors.initials: J
authors.lastname: Klinkmann
authors.forename: R
authors.initials: R
authors.lastname: Latza
mesh_terms: D000328:Adult; D001781:Blood Component Removal; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood* / Q000302:isolation & purification*; D008297:Male
chemical_list: D017270:Lipoprotein(a); D008077:Lipoproteins, LDL