Pentoxifylline in male-factor infertility: its therapeutic efficacy after oral administration.
OBJECTIVE
To determine whether the oral use of pentoxifylline improves the fertilization ability, concentration and motility of spermatozoa of poor fertilizer male subject.


METHODS
Analysis of the spermiogram parameters before and after oral pentoxifylline administration.


METHODS
Zeynep Kamil Women and Children's Hospital, Department of Infertility.


METHODS
Fourteen healthy, untreated male partners of couples who applied to our infertility department and were found to have poor semen parameters.


METHODS
Data of the semen analyses and fertilization rates are compared before and after treatment.


RESULTS
Before the treatment, the average percentage sperm motility and density were 30.1 +/- 8 (%) and 14.8 +/- 3.2 (10(6)/ml), respectively. The same parameters were found to be 37.8 +/- 13 (%) and 19.5 +/- 10 (10(6)/ml), respectively, following the treatment. Not significant, p = 0.08 and p = 0.116, respectively).


CONCLUSIONS
None of the semen parameters evaluated were improved by oral administration of pentoxifylline. Therefore pentoxifylline does not increase percentage motility and density of spermatozoa or the fertilization rates.
Faka
B
B
Api
M
M
Fiçicioğlu
C
C
Gürbüz
A
A
Oral
O
O
D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy*; D008297:Male; D010431:Pentoxifylline / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D010726:Phosphodiesterase Inhibitors / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects / Q000502:physiology*
D010726:Phosphodiesterase Inhibitors; D010431:Pentoxifylline