Growth hormone response to baclofen: a comparison of 10-mg and 20-mg doses in healthy men.
Growth hormone (GH) response and baclofen levels were measured in seven healthy adult men following a 10-mg and a 20-mg dose of oral baclofen (gamma-aminobutyric acidB agonist) to determine the preferred dose in baclofen challenge studies. Multivariate analysis of variance (ANOVA) with repeated measures revealed no differences between the doses. However, when a univariate ANOVA with repeated measures was performed for each dose, the 10-mg dose showed no significant GH response over time, whereas the 20-mg dose showed a significant GH response over time. The average delta GH (change in GH from baseline) was 7.84 ng/ml (SD = 10.17) for the 10-mg dose and 3.34 ng/ml (SD = 3.64) for the 20-mg dose. The variability in the delta GH response to the 10-mg dose was significantly greater than the response to the 20-mg dose of baclofen. This variance in GH response was not explained by the differences in serum baclofen levels. Thus, a 20-mg baclofen dose appears to be preferable to a 10 mg-dose in baclofen challenge studies.
Davis
L L
LL
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, USA.
Trivedi
M
M
Kramer
G L
GL
Rush
A J
AJ
Orsulak
P J
PJ
Akers
L
L
Petty
F
F
D000328:Adult; D001418:Baclofen / Q000008:administration & dosage* / Q000494:pharmacology* / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009125:Muscle Relaxants, Central / Q000008:administration & dosage* / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D009125:Muscle Relaxants, Central; D005680:gamma-Aminobutyric Acid; D013006:Growth Hormone; D001418:Baclofen