Dysplasia in Barrett's esophagus: diagnosis, surveillance and treatment.
Barrett's esophagus is a premalignant metaplastic change in the lining of the distal esophagus. It represents a peculiar form of healing which occurs in response to chronic gastroesophageal reflux disease. The condition should be considered in all patients undergoing endoscopy for symptoms of reflux disease and is confirmed when any biopsy shows the presence of specialized intestinal metaplasia irrespective of the macroscopic appearance of the distal esophagus. Endoscopic surveillance with multiple biopsy sampling of the esophageal mucosa is indicated for all medically fit patients with Barrett's esophagus. The diagnosis of dysplastic change within this abnormal mucosa requires histological examination of the biopsies by 2 independent but experienced pathologists. Identification of high-grade dysplasia heralds the development of invasive cancer and offers the physician an opportunity to intervene. Despite extensive endoscopic sampling of the esophageal mucosa the differentiation between high-grade dysplasia and invasive adenocarcinoma is unreliable. Esophagectomy remains the treatment of choice for patients with high-grade dysplasia since adenocarcinoma of the esophagus carries such a poor prognosis.
Clark
G W
GW
Department of Surgery, University of Southern California School of Medicine, Los Angeles 90033-4612, USA.
Ireland
A P
AP
DeMeester
T R
TR
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D001471:Barrett Esophagus / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D015415:Biomarkers; D001706:Biopsy; D004247:DNA / Q000737:chemistry; D016145:Endoscopy, Digestive System / Q000379:methods; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D004947:Esophagus / Q000473:pathology* / Q000601:surgery; D005434:Flow Cytometry; D005764:Gastroesophageal Reflux / Q000150:complications; D016158:Genes, p53; D006801:Humans; D008297:Male; D009092:Mucous Membrane / Q000473:pathology; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome
D015415:Biomarkers; D004247:DNA