title: Exaggerated platelet reactivity in major depression.
abstract: OBJECTIVE
  This study investigated whether depressed patients exhibit exaggerated platelet reactivity.
  
  
  METHODS
  In vivo platelet activation, secretion, and dose-response aggregation were measured in 12 depressed patients and eight normal comparison subjects after overnight bed rest and following orthostatic challenge.
  
  
  RESULTS
  The depressed patients exhibited increased platelet activation at baseline, demonstrated by increased binding of monoclonal antibody (moAb) annexin V protein reacting with prothrombinase complex binding sites. Following orthostatic challenge, the depressed patients exhibited increases in binding of moAbs PAC1 and anti-LIBS1 against activated glycoprotein IIb/IIIa and GE12 against P-selectin expressed upon secretion. The normal comparison subjects exhibited increases in platelet activation only with GE12.
  
  
  CONCLUSIONS
  Depressed patients exhibit enhanced baseline platelet activation and responsiveness in comparison with normal subjects. Heightened susceptibility to platelet activation may be a mechanism by which depression is a significant risk factor for ischemic heart and cerebrovascular disease and/or mortality after myocardial infarction.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Musselman
authors.forename: A
authors.initials: A
authors.lastname: Tomer
authors.forename: A K
authors.initials: AK
authors.lastname: Manatunga
authors.forename: B T
authors.initials: BT
authors.lastname: Knight
authors.forename: M R
authors.initials: MR
authors.lastname: Porter
authors.forename: S
authors.initials: S
authors.lastname: Kasey
authors.forename: U
authors.initials: U
authors.lastname: Marzec
authors.forename: L A
authors.initials: LA
authors.lastname: Harker
authors.forename: C B
authors.initials: CB
authors.lastname: Nemeroff
mesh_terms: D000328:Adult; D017304:Annexin A5 / Q000276:immunology / Q000502:physiology; D000911:Antibodies, Monoclonal / Q000276:immunology; D003866:Depressive Disorder / Q000097:blood* / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation / Q000276:immunology / Q000502:physiology*; D010974:Platelet Aggregation / Q000276:immunology / Q000502:physiology; D011187:Posture / Q000502:physiology; D012146:Rest
chemical_list: D017304:Annexin A5; D000911:Antibodies, Monoclonal; D000939:Epitopes