title: Filament heterogeneity within the dystrophic neurites of senile plaques suggests blockage of fast axonal transport in Alzheimer's disease.
abstract: In this study, the direct comparison of biopsy and autopsy tissue by morphological and immunocytochemical techniques, respectively, was used to document cytoskeletal changes of dystrophic neurites (DN) of senile plaques in Alzheimer's disease. This dual approach demonstrated several unreported abnormalities which, together with analogous findings in several experimental models, suggest that DN are associated with deficiencies in fast axonal transport and replacement of the cytoskeleton by an array of related abnormal filaments.
authors.affiliation: Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106-4901, USA.
authors.forename: D
authors.initials: D
authors.lastname: Praprotnik
authors.forename: M A
authors.initials: MA
authors.lastname: Smith
authors.forename: P L
authors.initials: PL
authors.lastname: Richey
authors.forename: H V
authors.initials: HV
authors.lastname: Vinters
authors.forename: G
authors.initials: G
authors.lastname: Perry
mesh_terms: D008841:Actin Cytoskeleton / Q000473:pathology* / Q000648:ultrastructure; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism / Q000648:ultrastructure; D001370:Axonal Transport; D006801:Humans; D007150:Immunohistochemistry; D016253:Microscopy, Immunoelectron; D008875:Middle Aged; D016501:Neurites / Q000473:pathology* / Q000648:ultrastructure; D016874:Neurofibrillary Tangles / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D016564:Amyloid beta-Protein Precursor