Humoral immunological response in patients with venom allergy during specific immunotherapy.
It was found that successful VIT (the negative challenge test) is associated with an increase in serum venom-specific IgG4 and a decrease in specific IgE. Also skin reactivity was significantly decreased in 9 patients with effective VIT. Or results confirmed that continuation of maintenance of VIT, 100 micrograms monthly for 2 years, is enough to protect most of venom allergic patients for systemic reaction to subsequent stings. The high prior level of venom-specific IgG4 can prognosticate a worse toleration of the rush VIT schedule.
Szymański
W
W
Department of Allergology, Medical Academy of Białystok.
Chyrek-Borowska
S
S
D000293:Adolescent; D000328:Adult; D000818:Animals; D000917:Antibody Formation; D001514:Bee Venoms / Q000276:immunology* / Q000627:therapeutic use; D003888:Desensitization, Immunologic; D005260:Female; D006801:Humans; D006927:Hymenoptera; D006967:Hypersensitivity / Q000276:immunology* / Q000628:therapy; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D012882:Skin Tests; D014862:Wasp Venoms / Q000276:immunology* / Q000627:therapeutic use
D001514:Bee Venoms; D007074:Immunoglobulin G; D014862:Wasp Venoms; D007073:Immunoglobulin E