title: Effect of cyclophosphamide on the acquisition of resistance to infestation by Rhipicephalus appendiculatus in rabbits.
abstract: Parenteral administration of cyclophosphamide in rabbits made resistant to infestation by the tick Rhipicephalus appendiculatus, resulted in abrogation of the resistance phenomenon. As a result, a high percentage (83%) of the larval ticks fed to repletion. This was in contrast to the control rabbits which were expressing the phenomenon of resistance to infestation by the ticks. In the latter, only 28% of the ticks fed to repletion. Cyclophosphamide administration in rabbits induced a leucopenia and depressed antibody response to the heterologous antigen, sheep red-blood cells.
authors.affiliation: International Centre for Insect Physiology and Ecology, Nairobi, Kenya.
authors.forename: M G
authors.initials: MG
authors.lastname: Binta
authors.forename: E Z
authors.initials: EZ
authors.lastname: Mushi
authors.forename: F R
authors.initials: FR
authors.lastname: Rurangirwa
mesh_terms: D000818:Animals; D000906:Antibodies / Q000097:blood; D003520:Cyclophosphamide / Q000627:therapeutic use*; D007110:Immunity, Active / Q000187:drug effects*; D011817:Rabbits / Q000276:immunology*; D013984:Tick Infestations / Q000517:prevention & control / Q000662:veterinary*; D013987:Ticks / Q000187:drug effects
chemical_list: D000906:Antibodies; D003520:Cyclophosphamide