[Evaluation of the stability of lipiodol-CDDP: suspension (LCS) by the pumping method].
We purified cisplatin (CDDP) powder from CDDP solution and prepared a Lipiodol-CDDP-suspension (LCS) using the oily contrast medium Lipiodol in order to investigate its stability. Non-ionic contrast materials have surface activity. Iopamidol was chosen as a coupling agent. The compounding ratios of Lipiodol/Iopamidol 300/CDDP for stable suspension were 1 ml/1 ml/10 mg and 1 ml/1 ml/20 mg. These were also obtained easily by using the pumping method.
Yamamoto
K
K
Department of Radiology, Osaka Medical College.
Shimizu
T
T
Narabayashi
I
I
D000970:Antineoplastic Agents; D002945:Cisplatin; D003287:Contrast Media; D004355:Drug Stability; D007261:Infusions, Intra-Arterial; D007459:Iodized Oil; D007479:Iopamidol; D010316:Particle Size; D011312:Pressure; D013535:Suspensions; D013678:Technology, Pharmaceutical
D000970:Antineoplastic Agents; D003287:Contrast Media; D013535:Suspensions; D007459:Iodized Oil; D007479:Iopamidol; D002945:Cisplatin