title: Inherited predisposition to colorectal neoplasia.
abstract: This review concentrates on the genetics of colorectal neoplasia. There is now a greater understanding of the molecular genetics of the inherited condition familial adenomatous polyposis and of the adenoma-carcinoma sequence in non-inherited colorectal cancer. We consider the evidence that sporadic colorectal cancer may also have an underlying genetic susceptibility.
authors.affiliation: Cardiff Royal Infirmary.
authors.forename: B M
authors.initials: BM
authors.lastname: Stephenson
authors.forename: N R
authors.initials: NR
authors.lastname: Hall
authors.forename: P J
authors.initials: PJ
authors.lastname: Finan
authors.forename: T
authors.initials: T
authors.lastname: Bishop
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D017491:Genes, APC; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D010375:Pedigree; D012307:Risk Factors