title: Dual therapy with doxycycline and ketoprofen compared to doxycycline in the treatment of uncomplicated non-gonococcal urethritis.
abstract: The aim of this study was to compare a combination of doxycyline and ketoprofen, and doxycycline alone in treating non-gonococcal urethritis (NGU), with particular emphasis on reducing recurrent or persistent disease. Sixty-five men with first episode acute NGU were enrolled between November 1992 and November 1994. The men were randomly assigned to either the doxycycline plus ketoprofen group, group A (doxycycline 100 mg twice daily for 10 days plus ketoprofen 200 mg daily for 10 days, n = 34), or the doxycycline group, group B (100 mg twice daily for 10 days, n = 31). Out of the 65 patients studied, Chlamydia trachomatis was isolated from 9 patients (13.8%), Ureaplasma urealyticum from 6 patients (9.2%) and Mycoplasma hominis from 2 patients (3.1%). At 6 weeks in group A, 16 patients (47%) were cured, one patient had a recurrence (2.9%), and 4 patients had persistent infection (11.8%). Eleven patients defaulted follow-up (32.4%) and 2 patients were dropped from the trial. In contrast, for group B, 13 patients (42%) were cured, 5 patients (16%) had a recurrence, 2 patients (6.5%) had persistent infection and 3 patients (9.7%) were reinfected. Eight patients (25.8%) defaulted follow-up. At 12 weeks, for group A, 14 patients (41.2%) remained cured, one patient (2.9%) had a recurrence, 4 patients (11.8%) had persistent infection and one patient (2.9%) was reinfected. Twelve patients (35.3%) defaulted follow-up. For group B, 8 patients (25.8%) remained cured, 6 patients (19.4%) had recurrence, 2 patients (6.5%) had persistent infection and 5 patients (16.1%) were reinfected. Ten patients (32.2%) defaulted follow-up. There were no statistically significant differences between the two groups except for patients with recurrent NGU where the difference (1 versus 6 patients) was statistically significant (P = 0.019).
authors.affiliation: National Skin Centre, Singapore.
authors.forename: Y K
authors.initials: YK
authors.lastname: Tay
authors.forename: C L
authors.initials: CL
authors.lastname: Goh
authors.forename: R K
authors.initials: RK
authors.lastname: Chan
authors.forename: A E
authors.initials: AE
authors.lastname: Ling
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D002690:Chlamydia Infections / Q000188:drug therapy; D002692:Chlamydia trachomatis; D004318:Doxycycline / Q000008:administration & dosage* / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage*; D008297:Male; D009175:Mycoplasma Infections / Q000188:drug therapy; D012008:Recurrence; D015231:Sexually Transmitted Diseases, Bacterial / Q000188:drug therapy*; D016896:Treatment Outcome; D016869:Ureaplasma Infections / Q000188:drug therapy; D016990:Ureaplasma urealyticum; D014526:Urethritis / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen; D004318:Doxycycline