Evidence for a tachykinin/cholinergic mediation of D1 agonist-induced turning in mice.
The turning behavior induced by the intrastriatal injection of the D1 agonist (+)SKF 38393 was blocked by the two selective nonpeptide tachykinin NK1 (SR 140333) (ID50 = 0.09 mg/kg ip) and NK2 (SR 48968) (ID50 = 1.4 mg/kg ip) receptor antagonists and by atropine (ID50 = 2.6 mg/kg ip). In addition, the turning induced by the intrastriatal injection of NK1 (septide) and NK2 ([Nle10]NKA(4-10)) receptor agonists were antagonized by atropine (ID50s = 1.1 mg/kg ip and 0.78 mg/kg ip, respectively). This behavioral study shows that tachykinin receptor activation is an essential component of DA-D1/Ach interaction in the mouse striatum and confirms the previously suggested functional importance of NK2 receptors in the central nervous system.
Poncelet
M
M
Sanofi Recherche, Montpellier, France.
Souilhac
J
J
Le Fur
G
G
Soubrie
P
P
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology*; D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001549:Benzamides / Q000494:pharmacology; D002799:Cholinergic Fibers / Q000187:drug effects / Q000502:physiology*; D018491:Dopamine Agonists / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism; D010880:Piperidines / Q000494:pharmacology; D011812:Quinuclidines / Q000494:pharmacology; D017447:Receptors, Dopamine D1 / Q000819:agonists*; D012399:Rotation; D013237:Stereoisomerism; D015320:Tachykinins / Q000502:physiology*
D001549:Benzamides; D018491:Dopamine Agonists; D010880:Piperidines; D011812:Quinuclidines; D017447:Receptors, Dopamine D1; D015320:Tachykinins; C085215:SR 140333; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; C073839:SR 48968; D000109:Acetylcholine