[A comparative evaluation of the cardiotropic effects of neurotensin and adrenaline in cats].
I.v. neurotensin induced acceleration of the heart rate which was prevented by with beta-adrenoreceptor blocker in anesthetised cats. Both neurotensin and adrenaline potentiated the vagal chronotropic effect and its tonic component. The synchronizing vagal component was inhibited by adrenaline. The findings suggest that the adrenergic link is involved in implementation of the cardiac effect exerted by neurotensin.
Osadchiĭ
O E
OE
Pokrovskiĭ
V M
VM
Kompaniets
O G
OG
Kurzanov
A N
AN
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology*; D002415:Cats; D004347:Drug Interactions; D004558:Electric Stimulation; D004562:Electrocardiography / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D008297:Male; D009496:Neurotensin / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D014630:Vagus Nerve / Q000502:physiology
D000319:Adrenergic beta-Antagonists; D002316:Cardiotonic Agents; D009496:Neurotensin; D011433:Propranolol; D004837:Epinephrine