title: Anti-HCV seroprevalence and risk factors of hepatitis C virus infection in Moroccan population groups.
abstract: Hepatitis C virus (HCV) seroprevalence and transmission routes were investigated in several groups of the Moroccan population. This study showed a low HCV seroprevalence in the Moroccan general population. However, haemodialysis patients and haemophiliacs were at higher risk of having HCV infection, since the prevalences were, respectively, 35.1 and 42.4% in comparison with the blood donors' prevalence (1.1%). These results indicated that parenteral exposure is the transmission pathway of HCV. To investigate the possibility of vertical HCV transmission, a cohort of healthy, unselected pregnant women were included in the study. A prevalence of 1% was found among them. Seven newborns were anti-HCV-positive, although, when RT-PCR was used to search for HCV RNA in their sera, none of them was viraemic. These data indicated that anti-HCV antibodies were passively acquired in these cases. We concluded that vertical transmission is absent when mothers are at low risk of contracting other parenterally or sexually transmitted diseases. Three percent of a group of patients of a centre for sexually transmitted diseases were repeatedly anti-HCV-positive, suggesting the possible sexual transmission of HCV. When screening 116 sera of anti-HIV-positive subjects, 19.8% were anti-HCV-positive. Furthermore, 17.9% of the sixty-seven patients who were proven to have sexually contracted HIV were also anti-HCV-positive. These data might reflect a likely cotransmission of these two viruses, hence suggesting HIV is a cofacter for HCV sexual transmission, as previously reported.
authors.affiliation: Institut Pasteur du Maroc, Casablanca, Maroc.
authors.forename: S
authors.initials: S
authors.lastname: Benjelloun
authors.forename: B
authors.initials: B
authors.lastname: Bahbouhi
authors.forename: S
authors.initials: S
authors.lastname: Sekkat
authors.forename: A
authors.initials: A
authors.lastname: Bennani
authors.forename: N
authors.initials: N
authors.lastname: Hda
authors.forename: A
authors.initials: A
authors.lastname: Benslimane
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004279:DNA, Viral / Q000097:blood*; D005260:Female; D006467:Hemophilia A / Q000821:virology; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006526:Hepatitis C / Q000453:epidemiology / Q000276:immunology / Q000635:transmission / Q000821:virology*; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D008875:Middle Aged; D009018:Morocco / Q000453:epidemiology; D011247:Pregnancy; D006435:Renal Dialysis; D012307:Risk Factors; D015229:Sexually Transmitted Diseases, Viral / Q000821:virology
chemical_list: D004279:DNA, Viral; D018937:Hepatitis C Antibodies