Correlation between hemoglobin oxygen affinity and activities of lipid peroxidation during hyperthermia.
Hemoglobin-oxygen affinity and main parameters of lipid peroxidation (LPO) such as conjugated dienes, malondialdehyde and Schiff bases were investigated in red blood cells and plasma of rats exposed by hot air (41 degrees C). We observed a rise of real p50 from 28.3 +/- 1.1 to 38.7 +/- 0.7 mm Hg (p < 0.01) and enhancement of LPO activities. Statistical analysis showed direct and strong linear correlation between p50 and LPO product concentrations.
Zinchuk
V
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Physiology Department, Grodno Medical Institute, Belorussia.
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D004912:Erythrocytes / Q000737:chemistry; D005334:Fever / Q000503:physiopathology*; D006454:Hemoglobins / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D010100:Oxygen / Q000378:metabolism*; D051381:Rats; D012044:Regression Analysis; D012545:Schiff Bases / Q000032:analysis
D015415:Biomarkers; D006454:Hemoglobins; D012545:Schiff Bases; D008315:Malondialdehyde; D010100:Oxygen