title: Microsatellite mapping of the bovine roan locus: a major determinant of White Heifer disease.
abstract: In the Belgian Blue Cattle breed, coat color variation is mainly under the influence of a single autosomal locus, the roan locus, characterized by a pair of codominant alleles: r+ (black) and R (white). Heterozygous r+R animals have intermingled black and white hairs, yielding the "blue" phenotype typical of the breed. Major interest for the roan locus stems from its pleiotropic effect on fertility, owing to the critical role of the R allele in the determinism of White Heifer Disease. We describe the linkage mapping of the roan locus to bovine Chromosome (Chr) 5, in the interval between microsatellite markers BPI and AGLA293, with an associated lodscore of 11.2. Moreover, we map a candidate gene, the Steel locus coding for the mast cell growth factor, to bovine Chr 5.
authors.affiliation: Département de Génétique, Université de Liège, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Charlier
authors.forename: B
authors.initials: B
authors.lastname: Denys
authors.forename: J I
authors.initials: JI
authors.lastname: Belanche
authors.forename: W
authors.initials: W
authors.lastname: Coppieters
authors.forename: L
authors.initials: L
authors.lastname: Grobet
authors.forename: M
authors.initials: M
authors.lastname: Mni
authors.forename: J
authors.initials: J
authors.lastname: Womack
authors.forename: R
authors.initials: R
authors.lastname: Hanset
authors.forename: M
authors.initials: M
authors.lastname: Georges
mesh_terms: D000818:Animals; D001483:Base Sequence; D002417:Cattle; D002874:Chromosome Mapping; D017931:DNA Primers; D005260:Female; D005611:Freemartinism / Q000235:genetics*; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008969:Molecular Sequence Data
chemical_list: D017931:DNA Primers