title: Probable risk of tumour induction after retro-orbital irradiation for Graves' ophthalmopathy.
abstract: Retrobulbar irradiation for Graves' ophthalmopathy is considered as a safe treatment and has recently been recommended as the initial treatment for patients with moderately severe eye problems. However, calculations using risk factors presently known reveal a theoretical risk of radiation-induced cancer of 1.2%. Therefore, the authors suggest that this treatment should be reserved for the elderly patient, for example above the age of 40-50 years.
authors.affiliation: Department of Clinical Oncology, University Hospital Leiden, Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Snijders-Keilholz
authors.forename: R J
authors.initials: RJ
authors.lastname: De Keizer
authors.forename: B M
authors.initials: BM
authors.lastname: Goslings
authors.forename: E W
authors.initials: EW
authors.lastname: Van Dam
authors.forename: J T
authors.initials: JT
authors.lastname: Jansen
authors.forename: J J
authors.initials: JJ
authors.lastname: Broerse
mesh_terms: D000328:Adult; D000367:Age Factors; D005128:Eye Diseases / Q000532:radiotherapy*; D005260:Female; D006111:Graves Disease / Q000532:radiotherapy*; D006801:Humans; D009010:Monte Carlo Method; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D019047:Phantoms, Imaging; D011336:Probability; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy / Q000009:adverse effects; D012307:Risk Factors; D012449:Safety