Intrathoracic hyperthermochemotherapeutic perfusion for the intrathoracic malignancies in gastric cancer.
OBJECTIVE
We introduced intrathoracic hyperthermochemotherapeutic perfusion to two patients with intrathoracic lesions in gastric cancer, one patient with pleural dissemination and the other with left lung metastases.


METHODS
Heated saline containing cisplatin, mitomycin C, and etoposide was circulated through the patient's thorax by a magnetic pump for an hour.


RESULTS
The effects of this procedure were estimated complete respose in the former and no change in the latter. There were no complications. While the intrathoracic temperatures were stable between 42.0 and 42.5 degrees C, systemic temperatures measured at esophagus, urinary bladder, pulmonary artery, and tympanic membrane very gradually increased and peaked under 38.6 degrees C. The drug concentration in the perfusate was much lower than the peak plasma concentration, though concentration in the plasma was higher than the peak plasma concentration.


CONCLUSIONS
This procedure is one of the preferable methods for treatment of intrathoracic lesions in gastric cancer because of easy temperature control, pharmacological advantage, and lack of side effects.
Fujimura
T
T
Second Department of Surgery, School of Medicine, Kanazawa University, Japan.
Yonemura
Y
Y
Nojima
N
N
Nakai
M
M
Kaji
M
M
Sahara
H
H
Ninomiya
I
I
Sugiyama
K
K
Nishimura
G
G
Miwa
K
K
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D010478:Chemotherapy, Cancer, Regional Perfusion; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008175:Lung Neoplasms / Q000556:secondary* / Q000628:therapy*; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage; D010997:Pleural Neoplasms / Q000556:secondary* / Q000628:therapy*; D012965:Sodium Chloride / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000473:pathology*
D012965:Sodium Chloride; D016685:Mitomycin; D005047:Etoposide; D002945:Cisplatin