HPLC and GLC determination of residual solvents in busulphan.
Quantitative methods using HPLC and GLC for the determination of residual pyridine and ethanol in busulphan have been developed. The measurement errors for pyridine and ethanol in busulphan samples (p = 0.95) were found to be 10% and 7%. It was shown that one recrystallization enabled pure busulphan to be prepared.
Kalchenko
O I
OI
Institute of Organic Chemistry, Ukrainian Academy of Sciences, Kiev.
Golub
V A
VA
Zavatskaja
I V
IV
D002066:Busulfan / Q000032:analysis*; D002138:Calibration; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D004340:Drug Contamination; D004350:Drug Residues / Q000032:analysis*; D000431:Ethanol / Q000032:analysis; D011725:Pyridines / Q000032:analysis; D012996:Solutions; D012997:Solvents / Q000032:analysis*
D011725:Pyridines; D012996:Solutions; D012997:Solvents; D000431:Ethanol; D002066:Busulfan