title: Back-to-back "one-pot" [18F]FDG syntheses in a single Siemens-CTI chemistry process control unit.
abstract: Simple changes in the chemistry, plumbing, and programming of the Siemens-CTI chemistry process control unit (CPCU) effectively double its output by enabling two back-to-back "1-pot" syntheses of 2-[18F]fluoro-2-deoxy-D-glucose in a single unit. Replacement of Kryptofix 2.2.2 with tetramethylammonium carbonate and elimination of diethyl ether from the procedure shorten synthesis time to 48 min, improve process and end-product safety, and increase end-of-synthesis yields from 37% to 52% by minimizing steps and transfer losses.
authors.affiliation: Department of Radiology, Indiana University School of Medicine, Indianpolis 46202-5121, USA.
authors.forename: B H
authors.initials: BH
authors.lastname: Mock
authors.forename: M T
authors.initials: MT
authors.lastname: Vavrek
authors.forename: G K
authors.initials: GK
authors.lastname: Mulholland
mesh_terms: D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry; D002614:Chelating Agents / Q000737:chemistry; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D019788:Fluorodeoxyglucose F18; D007553:Isotope Labeling / Q000379:methods; D051379:Mice; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000633:toxicity; D011854:Radiochemistry / Q000379:methods*
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D002614:Chelating Agents; D005462:Fluorine Radioisotopes; D000644:Quaternary Ammonium Compounds; D019788:Fluorodeoxyglucose F18; C006071:cryptating agent 222; D003847:Deoxyglucose; C027917:tetramethylammonium