Errors in time in pharmacokinetic studies.
Pharmacokinetic models with errors in the time variable were developed and explored by simulation in NONMEM. The precision of estimated parameters decreased with increasing error magnitude. The usual asymptotic standard error estimates were biased low by 10-50%. Accuracy and precision were not greatly diminished by ignoring errors in time when fitting models.
Jia
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Department of Clinical Pharmacology, Sandoz Research Institute, Sandoz Pharmaceuticals Corporation, East Hanover, New Jersey 07936, USA.
Nedelman
J R
JR
D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D015233:Models, Statistical; D010599:Pharmacokinetics; D012984:Software; D013997:Time Factors