[The "cognitive pupillary oscillation hypothesis" in patients with neurotic disorders and organic psychosyndrome: reliability and validity of a new psychophysiologic method].
A new psychophysiological method called "cognitive pupillary oscillation hypothesis" is introduced. Under the influence of a cognitive test (simple calculations) changes of the maximal amplitudes of pupillary oscillations, reflecting central nervous activation, are observed. In healthy subjects a retest reliability of 0.75-0.85 was calculated. Furthermore, the data after FFT (Fast Fourier Transform) of pupillary oscillations of two populations of patients (n = 509 and 396, respectively) showed a high stability. The validity of the method was determined by means of a procedure similar to cross validation. The use of the "cognitive pupillary oscillation hypothesis" for the differential diagnosis between patients with neurotic disorders (ICD 9: 300) (n = 73) and patients with organic brain syndrome (ICD 9: 290, ICD 291.2) (n = 34) is demonstrated.
Grünberger
J
J
Bereich für Klinische Psychodiagnostik, Universitätsklinik für Psychiatrie, Wien.
Linzmayer
L
L
Wytek
R
R
Grünberger
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001143:Arousal / Q000502:physiology*; D005133:Eye Movements / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D009497:Neurotic Disorders / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D011340:Problem Solving / Q000502:physiology*; D011603:Psychophysiology; D012016:Reference Values; D015203:Reproducibility of Results; D013001:Somatoform Disorders / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology