title: Distinctive developmental origins and specificities of the CD5+ B-cell subset.
abstract: In this review we present our recent work defining the pathway of B-cell development in the adult bone marrow of the mouse. We next present similarities and contrasts between fetal and adult B lymphopoiesis. Finally, considering the striking biases in specificity and V-gene usage between the progeny of fetal B lymphopoiesis, CD5+ B cells, and the bulk of adult-derived CD5- B cells, we suggest a model for developmentally distinct generation of this subset.
authors.affiliation: Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 1911
authors.forename: R R
authors.initials: RR
authors.lastname: Hardy
authors.forename: Y S
authors.initials: YS
authors.lastname: Li
authors.forename: K
authors.initials: K
authors.lastname: Hayakawa
mesh_terms: D000818:Animals; D016175:B-Lymphocyte Subsets / Q000502:physiology*; D001854:Bone Marrow Cells; D018956:CD5 Antigens / Q000032:analysis*; D005803:Genes, Immunoglobulin; D006410:Hematopoiesis; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000235:genetics
chemical_list: D018956:CD5 Antigens; D007135:Immunoglobulin Variable Region