title: Physicochemical studies of the structure and stability of polysaccharide-protein conjugate vaccines.
abstract: This short review highlights some areas in which spectroscopic methods have been applied to monitor the structure and stability of both the carbohydrate and protein moieties of polysaccharide-protein conjugate vaccines, such as those now in widespread clinical use for protection against Haemophilus influenzae infection.
authors.affiliation: Laboratory for Molecular Structure, National Institute for Biological Standards and Control, South Mimms, Herts, UK.
authors.forename: C
authors.initials: C
authors.lastname: Jones
authors.forename: D T
authors.initials: DT
authors.lastname: Crane
authors.forename: X
authors.initials: X
authors.lastname: Lemercinier
authors.forename: B
authors.initials: B
authors.lastname: Bolgiano
authors.forename: S E
authors.initials: SE
authors.lastname: Yost
mesh_terms: D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry / Q000276:immunology; D001426:Bacterial Proteins / Q000737:chemistry / Q000276:immunology; D001428:Bacterial Vaccines / Q000737:chemistry* / Q000276:immunology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002942:Circular Dichroism; D004355:Drug Stability; D005079:Excipients / Q000494:pharmacology; D018073:Haemophilus Vaccines / Q000737:chemistry / Q000276:immunology; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D011135:Polysaccharides, Bacterial / Q000737:chemistry* / Q000276:immunology; D013745:Tetanus Toxoid / Q000737:chemistry / Q000276:immunology; D018074:Vaccines, Conjugate / Q000737:chemistry* / Q000276:immunology
chemical_list: D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D001428:Bacterial Vaccines; D005079:Excipients; D018073:Haemophilus Vaccines; C055753:Haemophilus influenza type b polysaccharide vaccine-tetanus toxin conjugate; C061964:Haemophilus influenzae-type b polysaccharide-Neisseria meningitidis outer membrane protein conjugate vaccine; D011135:Polysaccharides, Bacterial; D013745:Tetanus Toxoid; D018074:Vaccines, Conjugate; C028581:CRM197 (non-toxic variant of diphtheria toxin); C061963:HibTITER protein, Haemophilus influenzae