A new mode of treatment of human papilloma virus associated anogenital lesions using a nonsteroid estrogen analogue.
Human papilloma virus (HPV)-induced condylomata acuminata in both sexes, as well as cervical dysplasias were treated locally with an ointment or a cream containing 25 mg clomiphene citrate per gram for a fortnight. The DNA of HPV 6, 11, HPV 16, 18, and HPV 31, 35, 51 was monitored pre- and post-therapeutically using an in situ hybridization assay. The therapeutic response to the drug was demonstrated by the disappearance of condylomata acuminata (100%), HPV DNA in cervical dysplasia (up to 80%), and penile genital warts (75%). Under this therapeutic regimen 78% of all cases treated became negative for the probed HPV. The pharmacological action of the drug was diminished in HPV 16, 18 positive lesions. Clomiphene is shown to be an effective anti-HPV drug.
Schön
H J
HJ
Institute of Medical Chemistry, University of Vienna.
Grgurin
M
M
Szekeres
T
T
Schurz
B
B
D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage*; D001005:Anus Neoplasms / Q000188:drug therapy*; D002996:Clomiphene / Q000008:administration & dosage*; D003218:Condylomata Acuminata / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy*; D005834:Genital Neoplasms, Male / Q000188:drug therapy*; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D009824:Ointments; D027383:Papillomaviridae / Q000187:drug effects*; D030361:Papillomavirus Infections / Q000188:drug therapy*; D014412:Tumor Virus Infections / Q000188:drug therapy*; D002578:Uterine Cervical Dysplasia / Q000188:drug therapy; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D009824:Ointments; D002996:Clomiphene