The most electron-donating sites in duplex DNA: guanine-guanine stacking rule.
The most readily oxidizable sites in one-electron oxidation of duplex DNA are shown to be the guanine (G) residues located 5' to guanine. Based on experimental results and ab initio calculations, G-G stacking rule has been proposed. This rule indicates the most electron-rich sites contained in B DNA and is very useful for understanding CT interactions between electron-accepting molecules and DNA.
Saito
I
I
Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Japan.
Takayama
M
M
Nakamura
T
T
Sugiyama
H
H
Komeda
Y
Y
Iwasaki
M
M
D001665:Binding Sites; D004247:DNA / Q000737:chemistry*; D004579:Electron Transport; D004583:Electrons; D006147:Guanine / Q000737:chemistry*; D008956:Models, Chemical; D008958:Models, Molecular; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D010084:Oxidation-Reduction
D006147:Guanine; D004247:DNA