title: Expression of sialyl Lewis(x) in hepatocellular carcinoma.
abstract: OBJECTIVE
  Expression of the sialyl Lewis(x) antigen, a cell adhesion molecule, was studied immunohistochemically in patients with hepatocellular carcinomas.
  
  
  METHODS
  Fifty-six patients who underwent curative hepatic resections from July 1984 to October 1990 were studied.
  
  
  RESULTS
  Hepatocellular staining patterns of the sialyl Lewis(x) in cancerous or noncancerous regions were divided into the three categories of high grade (HG), medium grade (MG), and low grade (LG). In cancerous regions, HG:54% (30/56); MG:13% (7/56); LG:34% (19/56). In noncancerous regions, HG: 86% (48/56), MG:4% (2/56), LG:11% (6/56). Patients with LG or MG sialyl Lewis(x) expression in cancerous regions had vascular invasion more frequently, and larger maximum diameters than HG patients, both with statistical significance (p<0.01, p<0.05, respectively). The 20 cases in which the expression of sialyl Lewis(x) in cancerous regions was downgraded compared with noncancerous regions (from HG in noncancerous regions to MG or LG in cancerous regions; from MG in noncancerous regions to LG in cancerous regions), also had vascular invasion significantly more frequently than the other 36 cases (p<0.02).
  
  
  CONCLUSIONS
  These results lead us to speculate that the diminishing change of hepatocellular sialyl Lewis(x) expression with malignant transformation, or the small amounts of hepatocellular sialyl Lewis(x) expression in cancerous regions, are related to tumor spread of hepatocellular carcinoma.
authors.affiliation: Department of Surgery II, Nagoya University School of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Tori
authors.forename: A
authors.initials: A
authors.lastname: Harada
authors.forename: A
authors.initials: A
authors.lastname: Nakao
authors.forename: T
authors.initials: T
authors.lastname: Nonami
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Takagi
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D016256:Lewis X Antigen / Q000378:metabolism*; D008099:Liver / Q000737:chemistry / Q000473:pathology; D008113:Liver Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D016256:Lewis X Antigen