title: Agranulocytosis, plasmacytosis, and thrombocytosis followed by a leukemoid reaction due to acute acetaminophen toxicity.
abstract: OBJECTIVE
  To describe a patient who developed hepatotoxicity, reactive plasmacytosis with thrombocytosis and life-threatening agranulocytosis, followed by a leukemoid reaction, apparently caused by acute acetaminophen toxicity.
  
  
  METHODS
  University-affiliated hospital.
  
  
  METHODS
  A 19-year old white women who took an overdose of acetaminophen developed hepatotoxicity and reactive plasmacytosis with thrombocytosis and life-threatening agranulocytosis, followed by a leukemoid reaction. Symptoms, signs, and laboratory findings regressed with symptomatic therapy during the follow-up period.
  
  
  CONCLUSIONS
  We believe that acute acetaminophen toxicity was responsible for these hematologic abnormalities. This profile of hematologic adverse effects associated with acetaminophen toxicity has not been reported previously.
authors.affiliation: Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Gürsoy
authors.forename: I C
authors.initials: IC
authors.lastname: Haznedaroğlu
authors.forename: I
authors.initials: I
authors.lastname: Celik
authors.forename: N
authors.initials: N
authors.lastname: Sayinalp
authors.forename: O I
authors.initials: OI
authors.lastname: Ozcebe
authors.forename: S V
authors.initials: SV
authors.lastname: Dündar
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy; D000583:Amikacin / Q000008:administration & dosage; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001853:Bone Marrow / Q000473:pathology*; D002442:Ceftazidime / Q000008:administration & dosage; D002511:Cephalosporins / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007955:Leukemoid Reaction / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy; D008099:Liver / Q000187:drug effects / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology*; D013922:Thrombocytosis / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy
chemical_list: D018712:Analgesics, Non-Narcotic; D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000082:Acetaminophen; D000583:Amikacin; D002442:Ceftazidime