title: Fluorescent polymerase chain reaction of a panel of CA repeats on chromosome 6 in the indolent phase of follicular centre cell lymphoma.
abstract: Twenty-four cases of histologically defined follicle centre cell (FCC) lymphoma have been examined for allele imbalance at 19 microsatellite loci spanning the length of chromosome 6, including six markers within the major histocompatibility complex (MHC), using fluorescent polymerase chain reaction (PCR) to amplify microsatellites. Nineteen cases were observed in which imbalance of one or more markers on chromosome 6 had occurred (79%). The frequency of allele imbalance was significantly higher on 6p than 6q, and two regions of deletions, 6p24-25 and 6p21.3-23, were identified in which the loci showed a significantly high allele imbalance frequency.
authors.affiliation: Department of Clinical Sciences: Pathological Science, University of Leeds, UK.
authors.forename: J
authors.initials: J
authors.lastname: Randerson
authors.forename: L
authors.initials: L
authors.lastname: Cawkwell
authors.forename: A
authors.initials: A
authors.lastname: Jack
authors.forename: F
authors.initials: F
authors.lastname: Lewis
authors.forename: P
authors.initials: P
authors.lastname: Johnson
authors.forename: P
authors.initials: P
authors.lastname: Evans
authors.forename: S
authors.initials: S
authors.lastname: Barrans
authors.forename: G J
authors.initials: GJ
authors.lastname: Morgan
mesh_terms: D002896:Chromosomes, Human, Pair 6; D005453:Fluorescence; D006801:Humans; D008224:Lymphoma, Follicular / Q000235:genetics*; D018895:Microsatellite Repeats; D016133:Polymerase Chain Reaction