Production of [18F]F2 using the 16O(3He,p)18F reaction.
For the first time, the 16O(3He,p)18F reaction has been used for the production of 18F electrophilic reagents. The predominant reactive chemical specie recovered in the single-step postirradiation gases was [18F]F2. Decay curve and Ge(Li) analyses established the main radionuclidic impurities in this nuclear reaction as 11C and 15O. Recovery of the 18F activity was exceptionally high, approaching 90% using an electroformed nickel target body. Consistent 18F recoveries for this nuclear reaction (approximately 70%) were realized with a novel aluminum target body. The utility of the [18F]F2 recovered from this oxygen gas target system in radiopharmaceutical preparations is demonstrated by the successful synthesis of 6-[18F]fluoro-L-dopa (11.0 mCi at EOB) via a fluorodemercuration method.
Bishop
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A
Department of Molecular and Medical Pharmacology, UCLA School of Medicine, USA.
Satyamurthy
N
N
Bida
G
G
Phelps
M
M
Barrio
J R
JR
D005462:Fluorine Radioisotopes / Q000737:chemistry* / Q000302:isolation & purification; D005740:Gases; D006371:Helium / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods; D010100:Oxygen / Q000737:chemistry*; D011854:Radiochemistry / Q000379:methods*
D005462:Fluorine Radioisotopes; D005740:Gases; D006371:Helium; D010100:Oxygen