Acetylacetonato-lanthanide complexes as eminent catalytic sites for artificial ribonucleases.
Acetylacetonato complexes of lutetium, ytterbium, thulium, and europium ions efficiently hydrolyze the phosphodiester linkage in adenylyl(3'-5')adenosine. The pseudo first-order rate constant (3.2 x 10(-2) h-1) at pH 7.2 and 30 degrees C for the 1:1 lutetium-acetylacetonato complex (0.5 mmol dm-3) is close to the value (3.5 x 10(-2) h-1) for free lutetium ion of the same concentration. Potentialities of these complexes as the catalytic sites of artificial ribonucleases are indicated.
Sumaoka
J
J
Department of Chemistry and Biotechnology, Graduate School of Engineering University of Tokyo, Japan.
Uchida
H
H
Komiyama
M
M
D001665:Binding Sites; D002384:Catalysis; D015226:Dinucleoside Phosphates / Q000737:chemistry; D006868:Hydrolysis; D007700:Kinetics; D008674:Metals, Rare Earth / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D012260:Ribonucleases / Q000737:chemistry*
D015226:Dinucleoside Phosphates; D008674:Metals, Rare Earth; D009942:Organometallic Compounds; C006412:adenylyl-(3'-5')-adenosine; D012260:Ribonucleases