Urinary trypsinogen activation peptides (TAP) are not increased in mild ERCP-induced pancreatitis.
Acute pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP) occurs in 3-18% of patients undergoing either diagnostic or therapeutic ERCP. We prospectively measured urinary trypsinogen activation peptides (TAP) by an automated anti-TAP enzyme-linked immunoassay among 107 patients 4 h after ERCP to determine whether this measurement helps in the early diagnosis of ERCP-induced pancreatitis. Pancreatitis was documented in 10 of 107 patients (9.3%). All episodes were graded as mild. Urinary TAP was not significantly increased. We conclude that measurement of urinary TAP 4 h after ERCP is not helpful in documenting mild ERCP-induced acute pancreatitis.
Banks
P A
PA
Center for Pancreatic Disease, Brigham and Women's Hospital, Harvard Medical School, Harvard School of Public Health, Boston, Massachusetts, USA.
Carr-Locke
D L
DL
Slivka
A
A
Van Dam
J
J
Lichtenstein
D R
DR
Hughes
M
M
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides / Q000652:urine*; D010195:Pancreatitis / Q000175:diagnosis* / Q000652:urine; D011446:Prospective Studies; D014362:Trypsinogen
D009842:Oligopeptides; C080396:trypsinogen activation peptide; D014362:Trypsinogen