The incidence of chromogranin A defined endocrine cells decreases with tumour progression in gastric adenocarcinoma.
The immunohistochemical expression of chromogranin A (CGA) was investigated in 60 normal mucosas, 95 primary tumours and 38 metastatic lymph nodes. CGA was expressed in 100% of the normal mucosas, 61% of the primary tumours that were restricted within the submucosal layer, 21% of the primary tumours that invaded beyond the submucosal layer, and 11% of the metastatic lymph nodes. The 5-year survival rates in patients with negative and positive expression of CGA in primary tumours were 60.4% and 74.6%, respectively. These results indicate that endocrine cells occupy an integral part of gastric adenocarcinoma with regard to tumour progression.
Ikeda
Y
Y
Department of Surgery II, Kyushu University, Fukuoka, Japan.
Mori
M
M
Haraguchi
Y
Y
Sasaki
O
O
Sugimachi
K
K
D000230:Adenocarcinoma / Q000473:pathology* / Q000556:secondary; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis* / Q000235:genetics; D018450:Disease Progression; D004702:Endocrine Glands / Q000473:pathology*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D013274:Stomach Neoplasms / Q000473:pathology*; D015996:Survival Rate
C506150:CHGA protein, human; D053379:Chromogranin A; D002864:Chromogranins