Glial-derived neurotrophic factor (GDNF) induced morphological differentiation of an immortalized monoclonal hybrid dopaminergic cell line of mesencephalic neuronal origin.
Monoclonal hybrid cell lines derived from either mesencephalic or striatal neuronal parents were screened for the effects of glial-derived neurotrophic factor (GDNF) on morphological differentiation. The mesencephalic dopaminergic MN9D cell line responded to GDNF with a 3- to 4-fold increase in the number of differentiated solitary cells and provides an unlimited source of monoclonal cells for studies on the mechanism of action of GDNF and the nature of its receptor.
Heller
A
A
Department of Pharmacological and Physiological Sciences, University of Chicago, IL 60637, USA. effe@midway.uchicago.edu
Price
S
S
Won
L
L
D000818:Animals; D002460:Cell Line; D004298:Dopamine / Q000378:metabolism*; D051100:Glial Cell Line-Derived Neurotrophic Factor; D006822:Hybrid Cells / Q000187:drug effects*; D008636:Mesencephalon / Q000187:drug effects*; D009414:Nerve Growth Factors / Q000494:pharmacology*; D009419:Nerve Tissue Proteins / Q000494:pharmacology*
D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D004298:Dopamine