title: Event-related potentials as indices of subclinical neurological differences in HIV patients during rapid decision making.
abstract: The authors examined decision making in HIV patients under slow and rapid information deliveries. Thirteen asymptomatic, HIV-infected (HIV+) subjects with known seroconversion dates and 13 healthy control subjects were instructed to detect the "oddball" target tones among nontarget tones during single-channel (slow) and dual-channel (rapid) deliveries. Event-related potentials (ERPs) from midline scalp sites, reaction time, and "hits" were recorded. Behaviorally, the two groups performed similarly, and during single-channel delivery they produced similar ERPs indexing target detection. However, during dual-channel delivery the HIV+ group showed atypical morphology in the region of the P300 cognitive decision-making component compared with the control group. Auditory ERPs elicited by rapid, dichotic stimulus presentations appeared sensitive to subclinical effects of HIV-related neuropathology in individuals who had been HIV-positive for 3 months to 8 years.
authors.affiliation: Cognitive Performance and Psychophysiology Department, Naval Health Research Center, San Diego, California, USA.
authors.forename: S E
authors.initials: SE
authors.lastname: Linnville
authors.forename: F S
authors.initials: FS
authors.lastname: Elliott
authors.forename: G E
authors.initials: GE
authors.lastname: Larson
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D003071:Cognition / Q000502:physiology; D003657:Decision Making / Q000502:physiology*; D004007:Dichotic Listening Tests; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D015658:HIV Infections / Q000503:physiopathology / Q000523:psychology*; D015497:HIV-1; D006801:Humans; D008297:Male; D011930:Reaction Time / Q000502:physiology