title: Varicella-zoster ventriculo-encephalitis and spinal cord infarction in a patient with AIDS.
abstract: Varicella-zoster virus (VZV) infection is usually benign and self-limited. However, particularly in the immunosuppressed host, serious central nervous system complications may occur, including encephalitis, myelitis, and cerebral vascular occlusion. We report the case of a 57-year-old male with AIDS, who rapidly developed a sixth cranial nerve palsy and progressive myelopathy. There was no antecedent zoster rash. Autopsy revealed VZV ventriculo-encephalitis and vasculitis, as well as a transverse infarction of the spinal cord without evidence of direct infection of the cord parenchyma. Spinal cord infarction secondary to VZV vasculitis is an unusual cause of myelopathy in immunosuppressed patients.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104-6079, USA.
authors.forename: L C
authors.initials: LC
authors.lastname: Kenyon
authors.forename: E
authors.initials: E
authors.lastname: Dulaney
authors.forename: K T
authors.initials: KT
authors.lastname: Montone
authors.forename: H I
authors.initials: HI
authors.lastname: Goldberg
authors.forename: G T
authors.initials: GT
authors.lastname: Liu
authors.forename: E
authors.initials: E
authors.lastname: Lavi
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000473:pathology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000368:Aged; D018792:Encephalitis, Viral / Q000209:etiology*; D014645:Herpesvirus 3, Human / Q000472:pathogenicity*; D006801:Humans; D007238:Infarction / Q000209:etiology*; D008297:Male; D013116:Spinal Cord / Q000098:blood supply* / Q000473:pathology*; D014657:Vasculitis / Q000209:etiology