[The Dexamethasone Reference Standard (Control 931) of the National Institute of Health Sciences].
Raw dexamethasone material was tested for preparation of the "Dexamethasone Reference Standard (Control 931)". Analytical data obtained were as follows: melting point, 245.1 degrees C (decomposition); infrared spectrum, the same as that of the JP Dexamethasone Reference Standard; optical rotation, -alpha-20D = + 76.75 degrees; thin-layer chromatography, two impurities were detected; high-performance liquid chromatography (HPLC), one impurity was detected; loss on drying, 0.14%; assay result, 99.4% by HPLC. Based on the above findings, the raw material was authorized as the JP Dexamethasone Reference Standard (Control 931).
Kitajima
A
A
Yoshii
K
K
Komatsu
H
H
Ishimitsu
S
S
Okada
S
S
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003907:Dexamethasone / Q000032:analysis / Q000592:standards*; D006077:Government Agencies; D007564:Japan; D010602:Pharmacopoeias as Topic / Q000592:standards
D003907:Dexamethasone