Effects of amylin on appetite regulation and memory.
Amylin has been demonstrated to decrease food intake in mice and rats. Amylin is effective when delivered both peripherally and directly into the central nervous system. Amylin's effect on food intake is not aversive. Amylin may produce its effect on food intake by modulating nitric oxide synthesis. Calcitonin gene related peptide also decreases food intake after peripheral and central administration. In addition, amylin has been demonstrated to modulate memory at both peripheral and central sites.
Morley
J E
JE
Education and Clinical Center, St. Louis VA Medical Center, MO, USA.
Flood
J F
JF
Farr
S A
SA
Perry
H J
HJ
Kaiser
F E
FE
Morley
P M
PM
D000682:Amyloid / Q000494:pharmacology*; D000818:Animals; D000855:Anorexia / Q000209:etiology; D001066:Appetite / Q000187:drug effects*; D015740:Calcitonin Gene-Related Peptide / Q000502:physiology; D006801:Humans; D058228:Islet Amyloid Polypeptide; D008568:Memory / Q000187:drug effects*
D000682:Amyloid; D058228:Islet Amyloid Polypeptide; D015740:Calcitonin Gene-Related Peptide