[The effect of calcium antagonists and the potassium depolarization of plasma membranes on pepsinogen extrusion by dispersed gastric glands].
The effect exerted by the calcium-free medium, calcium antagonists (La3+, Mn2+, nifedipin, nitrendipin, verapamil) and by potassium depolarization on the pepsinogen extrusion by the dispersed gastric glands of guinea pigs has been investigated. The obtained results prove the absence of potential-dependent Ca2+ transport into the gastric gland cells. Apparently Ca(2+)-transport into these cells is mediated by the chemosensitive Ca2+ channels.
Dubyts'kyĭ
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Sabadash
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D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D010435:Pepsinogens / Q000187:drug effects* / Q000378:metabolism; D011188:Potassium / Q000502:physiology*; D011189:Potassium Chloride / Q000494:pharmacology
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D010435:Pepsinogens; D011189:Potassium Chloride; D011188:Potassium