title: Elevation of plasma interleukin-6 level in patients undergoing oral and maxillofacial surgery.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the response of peripheral interleukin-6 associated with oral and maxillofacial surgery.
  
  
  METHODS
  Fifteen patients undergoing elective oral and maxillofacial surgery were studied. We investigated the change in plasma interleukin-6 level during and after surgery and the correlation between plasma interleukin-6 level and surgical procedure. Plasma interleukin-6 levels were measured by enzyme-linked immunosorbent assay. Statistical significance was determined by nonparametric methods.
  
  
  RESULTS
  Elevation of plasma interleukin-6 level was detected at 2 to 6 hours after incision and observed to reach a peak level within 6 hours after the end of surgery. There were significant correlations between plasma interleukin-6 level and duration of surgery or response of C-reactive protein.
  
  
  CONCLUSIONS
  The results suggested that interleukin-6 would be released by surgical injury and elevation of plasma interleukin-6 level would be associated with magnitude of tissue damage in oral and maxillofacial surgery.
authors.affiliation: Department of Dental Anesthesiology, Okayama University Dental Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miyawaki
authors.forename: S
authors.initials: S
authors.lastname: Maeda
authors.forename: M
authors.initials: M
authors.lastname: Shimada
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D017558:Elective Surgical Procedures; D004797:Enzyme-Linked Immunosorbent Assay; D005145:Face / Q000601:surgery*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000601:surgery*; D056948:Orthognathic Surgical Procedures; D011182:Postoperative Care; D013997:Time Factors
chemical_list: D015850:Interleukin-6; D002097:C-Reactive Protein