[Preventive effect of intracisternal methylprednisolone on symptomatic vasospasm after aneurysmal subarachnoid hemorrhage].
A series of 103 patients with ruptured cerebral aneurysms were treated by intracranial irrigation, after aneurysmal clipping, with pH 8.0 Hartmann solution containing 1 mg/ml of methylprednisolone sodium succinate, during operation. Postoperatively, 5 ml/day of the solution was also injected until day 14, percutaneously through an Ommaya reservoir into the cisterns around the clipped aneurysm. Six (5.7%) of the 103 patients suffered symptomatic vasospasm postoperatively. The Glasgow Outcome Scale at discharge of all patients indicated good recovery, Moderately disabled, Severely disabled and Vegetative state in 74 (72%), 18 (17%), 9 (9%) and 2 (2%) patients respectively. As a complication, subdural effusion was noticed in 17 (17%) patients, without any influence on outcome at all.
Ohkuma
H
H
Department of Neurosurgery, Hirosaki University School of Medicine, Japan.
Suzuki
S
S
Ogane
K
K
Fujita
S
S
Shibata
S
S
Ito
K
K
Kimura
M
M
D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D007267:Injections; D002532:Intracranial Aneurysm / Q000150:complications* / Q000601:surgery; D002546:Ischemic Attack, Transient / Q000517:prevention & control*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000601:surgery
D008775:Methylprednisolone