title: Modification of adrenergic reactivity in rat tail artery by dietary lipids and calcium channel antagonists.
abstract: 1. The antiatherosclerotic activity of dihydropyridines (DHP), potent calcium antagonists, was studied with respect to prevention of hypercontractility of perfused rat tail arteries. 2. Used for 1 month, atherogenic diet increased pressor responses to norepinephrine (NE) in Ca(2+)-free physiological salt solution (PSS), and PSS containing Ca(2+). 3. When nifedipine (NIF) or nitrendipine (NIT) was administered simultaneously with an atherogenic diet, the contractile activity of NE in Ca(2+)-free PSS was attenuated. Moreover, vasoconstrictor responses to NE in PSS containing Ca2+ were inhibited after 1-month treatment with NIT and nimodipine (NIM). 4. NIF, NIT and NIM prevented atherosclerosis-induced vascular hyperreactivity to alpha-adrenoceptor agonists in rat tail artery.
authors.affiliation: Department of Pharmacology, Silesian Academy of Medicine, Katowice, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Okopién
authors.forename: H I
authors.initials: HI
authors.lastname: Trzeciak
mesh_terms: D000818:Animals; D001158:Arteries / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004036:Diet, Atherogenic; D004041:Dietary Fats / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000294:innervation*; D009543:Nifedipine / Q000494:pharmacology; D009553:Nimodipine / Q000494:pharmacology; D009568:Nitrendipine / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects*; D013566:Sympathomimetics / Q000494:pharmacology; D013623:Tail / Q000098:blood supply*
chemical_list: D002121:Calcium Channel Blockers; D004041:Dietary Fats; D013566:Sympathomimetics; D009553:Nimodipine; D009568:Nitrendipine; D009543:Nifedipine; D009638:Norepinephrine