title: Failure to detect missense mutations in the S182 gene in a series of late-onset Alzheimer's disease cases.
abstract: The possibility of an interaction of multiple genes has been speculated in pathogenesis of Alzheimer's disease (AD). Because we have recently cloned a novel gene S182 bearing five different missense mutations which segregate with early-onset familial AD, we sought the frequency of these mutations in familial and sporadic late-onset AD to clarify the incidence of these mutations in the disease. The current study showed lack of these mutations in 118 independent subjects affected with late-onset Alzheimer's disease.
authors.affiliation: Department of Medicine, Centre for Research in Neurodegenerative Diseases, University of Toronto, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Tsuda
authors.forename: H
authors.initials: H
authors.lastname: Chi
authors.forename: Y
authors.initials: Y
authors.lastname: Liang
authors.forename: E A
authors.initials: EA
authors.lastname: Rogaeva
authors.forename: R
authors.initials: R
authors.lastname: Sherrington
authors.forename: G
authors.initials: G
authors.lastname: Levesque
authors.forename: M
authors.initials: M
authors.lastname: Ikeda
authors.forename: E I
authors.initials: EI
authors.lastname: Rogaev
authors.forename: D
authors.initials: D
authors.lastname: Pollen
authors.forename: M
authors.initials: M
authors.lastname: Freedman
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D001483:Base Sequence; D003001:Cloning, Molecular; D017931:DNA Primers; D005796:Genes; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics* / Q000502:physiology; D016133:Polymerase Chain Reaction; D053764:Presenilin-1
chemical_list: D017931:DNA Primers; D008565:Membrane Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1