In vitro investigation of immunoglobulin treatment mechanisms in autoimmune diseases.
High doses of immunoglobulins (IVIG) may have beneficial effects in patients with autoimmune diseases. In this review several different mechanisms of action are discussed. These mechanisms include effects on the effector phase of the immune response, on the initial steps of the immune response and on the mixed lymphocytic reaction.
Brand
A
A
University Hospital Leiden, The Netherlands.
Vuist
W M
WM
Van Schaik
I N
IN
Vermeulen
M
M
D000917:Antibody Formation / Q000187:drug effects; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007109:Immunity / Q000187:drug effects; D016756:Immunoglobulins, Intravenous / Q000494:pharmacology; D066298:In Vitro Techniques; D007959:Lymphocyte Culture Test, Mixed; D011961:Receptors, Fc / Q000276:immunology; D017452:Receptors, IgG / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D016756:Immunoglobulins, Intravenous; D011961:Receptors, Fc; D017452:Receptors, IgG