title: Functional brain asymmetry, handedness and age characteristics of climacterium in women.
abstract: A total of 1985 women aged between 55 and 65 were distributed into two groups (145 left-handers and 1840 right-handers). They were asked to complete a questionnaire on the appearance of menopause, duration of menopausal transition and age of menopause. In left-handed women a significantly earlier appearance of premenopause was established together with a shorter menopause transition and an earlier occurrence of menopause. These results give grounds for a correlation between handedness, functional brain asymmetry, respectively and the genetically determined fading away of ovary steroidogenesis associated with the appearance and progression of the climacterium. In light of the available literature we assume that progressive reduction in ovarian function during climacterium is coupled with possible specific functioning of the hypothalamo-pituitary-gonadal axis, dependent on the type of hemispheric asymmetry.
authors.affiliation: Department of Physiology, Medical University Varna, Bulgaria.
authors.forename: P
authors.initials: P
authors.lastname: Nikolova
authors.forename: N
authors.initials: N
authors.lastname: Negrev
authors.forename: Z
authors.initials: Z
authors.lastname: Stoyanov
authors.forename: R
authors.initials: R
authors.lastname: Nikolova
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D002979:Climacteric / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008593:Menopause / Q000502:physiology; D008875:Middle Aged; D017697:Premenopause / Q000502:physiology