Side reactions in the pyroglutamic acid-7-amino-4-methylcoumarin synthesis.
N-Formylpyroglutamic acid-7-amido-4-methylcoumarine and pyroglutamyl-pyroglutamic acid-7-amido-4-methylcoumarin are the major products in the synthesis of pyroglutamic acid-7-amido-4-methylcoumarin by phosphorus pentachloride in dimethylformamide and dicyclohexylcarbodiimide under pyridine activation.
Zicane
D
D
Department of Chemistry, Technical University, Riga, Latvia.
Petrova
M
M
Tetere
Z
Z
Kreishman
G
G
Brooks
E
E
Karlson
J
J
Kalejs
U
U
D002712:Chlorides / Q000737:chemistry; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry*; D004024:Dicyclohexylcarbodiimide / Q000737:chemistry; D010758:Phosphorus / Q000737:chemistry; D017553:Phosphorus Compounds; D011761:Pyrrolidonecarboxylic Acid / Q000737:chemistry* / Q000031:analogs & derivatives
D002712:Chlorides; D003374:Coumarins; D017553:Phosphorus Compounds; C102731:pyroglutamic acid 7-amino-4-methylcoumarin; D010758:Phosphorus; D004024:Dicyclohexylcarbodiimide; C043693:phosphorus chloride; C028743:7-amino-4-methylcoumarin; D011761:Pyrrolidonecarboxylic Acid