title: Peripheral osteopenia in adult patients with insulin-dependent diabetes mellitus.
abstract: Alterations in bone metabolism in diabetes mellitus is a topic of special interest. Bone blood flow is increased in the distal limb of diabetic patients, which is believed to increase osteoclastic activity. We measure bone mineral density using dual-photon absorptiometry in the distal lower limb, the femoral neck, and the lumbar spine in 41 IDDM patients and in 30 control persons. In the diabetic group there was a 10% reduction of bone mineral density in the femoral neck (p < 0.01) and a 12% reduction in the distal limb (p < 0.001) compared with the control group. No significant difference was found in the lumbar spine (p = 0.22). Our data yield incidence for peripheral osteopenia in IDDM-patients, independent of any systemic bone disease such as osteoporosis. A link between decreased bone mineral density and diabetic neuropathy has been observed for the femoral neck (p < 0.001), but not for the distal limb or axial skeleton. Whether there is a common aetiological link or a casual connection between diabetic neuropathy and bone mineral density has still to be determined.
authors.affiliation: Department of Endocrinology and Internal Medicine, University Hospital Mainz, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Forst
authors.forename: A
authors.initials: A
authors.lastname: Pfützner
authors.forename: P
authors.initials: P
authors.lastname: Kann
authors.forename: B
authors.initials: B
authors.lastname: Schehler
authors.forename: R
authors.initials: R
authors.lastname: Lobmann
authors.forename: H
authors.initials: H
authors.lastname: Schäfer
authors.forename: J
authors.initials: J
authors.lastname: Andreas
authors.forename: A
authors.initials: A
authors.lastname: Bockisch
authors.forename: J
authors.initials: J
authors.lastname: Beyer
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D000419:Albuminuria; D015992:Body Mass Index; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003404:Creatinine / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000503:physiopathology*; D005260:Female; D005269:Femur; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007866:Leg; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012044:Regression Analysis
chemical_list: D003404:Creatinine; D006442:Glycated Hemoglobin