title: Oral midazolam premedication for paediatric day case patients.
abstract: Forty-nine children having day-stay surgical procedures were randomly assigned to receive oral midazolam 0.75 mg.kg-1 or placebo in a double blind fashion. The child's level of anxiety was assessed before premedication using parental, child and observer scales. The child and observer anxiety scores were repeated in the anaesthetic room. Most children presented for anaesthesia in a calm state, irrespective of whether they had received midazolam. Parents tended to overestimate their child's level of anxiety. Observer anxiety scores reliably predicted behaviour during induction of anaesthesia in the absence of a sedative. Observer scores decreased in the midazolam group (P < 0.02), but not in the placebo group, children below six years having the greatest decrease with midazolam. The median time to discharge from hospital was delayed by 30 min in the midazolam group (P < 0.01). Children do not require routine sedative premedication for day case procedures, but oral midazolam is useful in producing calm behaviour in those children with high observer anxiety scores.
authors.affiliation: Department of Anaesthesia, General Infirmary, Leeds, UK.
authors.forename: S H
authors.initials: SH
authors.lastname: Cray
authors.forename: J L
authors.initials: JL
authors.lastname: Dixon
authors.forename: C M
authors.initials: CM
authors.lastname: Heard
authors.forename: D S
authors.initials: DS
authors.lastname: Selsby
mesh_terms: D000284:Administration, Oral; D000556:Ambulatory Surgical Procedures; D001007:Anxiety; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007223:Infant; D008874:Midazolam / Q000008:administration & dosage*; D011229:Preanesthetic Medication; D011446:Prospective Studies
chemical_list: D006993:Hypnotics and Sedatives; D008874:Midazolam