title: Development of an experimental model allowing discrimination between virulent and avirulent isolates of Serpulina (Treponema) hyodysenteriae.
abstract: Variation in virulence among different strains of Serpulina hyodysenteriae was studied by oral inoculation of specific pathogen free piglets and CD-1 mice. Piglets infected with serotype 2 reference strain B204 and an untypable field strain LHV-90-9-I had severe diarrhea tainted intermittently with mucus and fresh blood. The piglets inoculated with B169, B8044, B6933, and ACK300-8 reference strains representing serotypes 3, 5, 6, and 7 respectively developed moderate diarrhea. However, reference strains B234 and A-1 of serotypes 1 and 4, respectively, failed to cause any diarrhea. None of the S. hyodysenteriae strains caused diarrhea in mice. The results indicate a great variation in virulence among strains of different serotypes of S. hyodysenteriae. Mice were less susceptible to infection with S. hyodysenteriae.
authors.affiliation: Groupe de recherche sur les Maladies Infectieuses du Porc, Département de pathologie et microbiologie, Université de Montréal, Saint-Hyacinthe, Québec, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Achacha
authors.forename: S
authors.initials: S
authors.lastname: Messier
authors.forename: K R
authors.initials: KR
authors.lastname: Mittal
mesh_terms: D000818:Animals; D017401:Brachyspira hyodysenteriae / Q000472:pathogenicity*; D003967:Diarrhea / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary; D004195:Disease Models, Animal; D015994:Incidence; D007413:Intestinal Mucosa / Q000382:microbiology; D008297:Male; D051379:Mice; D012376:Rodent Diseases / Q000453:epidemiology / Q000382:microbiology; D013145:Spirochaetales Infections / Q000453:epidemiology / Q000662:veterinary; D013552:Swine / Q000382:microbiology*; D013553:Swine Diseases / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology; D014774:Virulence