Immune thrombocytopenia and hemolytic anemia associated with Hodgkin disease.
OBJECTIVE
We discuss an unusual clinical presentation of Hodgkin disease with immune thrombocytopenia and autoimmune hemolytic anemia.


METHODS
A 4-year-old boy presented to us with a large anterior mediastinal mass, thrombocytopenia, and Coombs' positive hemolytic anemia refractory to transfusion therapy. Biopsy of the anterior mediastinal mass was possible only after administration of intravenous immunoglobulin to raise the platelet count. The immune manifestations decreased with initiation of appropriate chemotherapy.


RESULTS
The child was able to successfully complete chemotherapy and radiation therapy and has no clinical or laboratory evidence of persistent autoimmune phenomena.


CONCLUSIONS
Immune thrombocytopenia with autoimmune hemolytic anaemia is a rare presenting manifestation of Hodgkin disease and can present difficulty in diagnosis and management.
Shah
S J
SJ
Louisiana State University Medical Center and Children's Hospital, New Orleans, USA.
Warrier
R P
RP
Ode
D L
DL
Lele
H E
HE
Yu
L C
LC
D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications*; D002675:Child, Preschool; D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D008297:Male; D013921:Thrombocytopenia / Q000150:complications* / Q000276:immunology