title: Serial chromosomal change during the progression of hepatocellular carcinoma.
abstract: We investigated the chromosomal loss pattern of a primary large nodule and one of the disseminated intrahepatic small nodules of hepatocellular carcinoma in one patient using RFLP analysis. Using D17S30 probe mapping to 17p, loss of heterozygosity was observed both the main nodule and the disseminated nodule, however, using IGLV probe mapping to 22q, loss of heterozygosity was observed only in the disseminated nodule. This is the case in which serial loss of chromosome in the progression on hepatocellular carcinoma was highly suggested.
authors.affiliation: First Department of Internal Medicine, Kyushu University, Fukuoka.
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: J
authors.initials: J
authors.lastname: Kudo
authors.forename: H
authors.initials: H
authors.lastname: Ishibashi
authors.forename: N
authors.initials: N
authors.lastname: Masumoto
authors.forename: Y
authors.initials: Y
authors.lastname: Hirata
authors.forename: Y
authors.initials: Y
authors.lastname: Niho
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D002869:Chromosome Aberrations; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged