title: Relationship of in vitro data on drug metabolism to in vivo pharmacokinetics and drug interactions: implications for diazepam disposition in humans.
authors.forename: J
authors.initials: J
authors.lastname: Schmider
authors.forename: D J
authors.initials: DJ
authors.lastname: Greenblatt
authors.forename: L L
authors.initials: LL
authors.lastname: von Moltke
authors.forename: R I
authors.initials: RI
authors.lastname: Shader
mesh_terms: D001189:Aryl Hydrocarbon Hydroxylases; D065731:Cytochrome P-450 CYP2C19; D051544:Cytochrome P-450 CYP3A; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003975:Diazepam / Q000493:pharmacokinetics*; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008657:Metabolic Clearance Rate; D006899:Mixed Function Oxygenases / Q000378:metabolism*
chemical_list: D007527:Isoenzymes; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; C104464:CYP3A protein, human; D065731:Cytochrome P-450 CYP2C19; D051544:Cytochrome P-450 CYP3A; D003975:Diazepam