[Agents inducing cell death of the vascular wall].
Arterial wall is constituted by endothelial cells, smooth muscle cells and fibroblasts. A number of agents are capable of inducing damages in these cells leading either to apoptosis or necrosis involved in various pathologies. Such agents are constituted by: bacterial endotoxins, mediators and modulators of immunitary and/or inflammatory systems, drugs, reactive oxygen metabolites, free radicals, cholesterol oxidation derivatives included or not in lipoproteins. The study of the mechanisms of action implied in cell death would permit a better understanding of vascular diseases and open new therapeutic perspectives.
Munsch
B
B
Laboratoire de biochimie des lipoprotéines, hôpital du Bocage, Dijon, France.
Lizard
G
G
Gueldry
S
S
Gambert
P
P
D016923:Cell Death / Q000187:drug effects*; D004730:Endothelium, Vascular / Q000166:cytology*; D004731:Endotoxins / Q000494:pharmacology; D005347:Fibroblasts / Q000166:cytology*; D005609:Free Radicals / Q000494:pharmacology; D006801:Humans; D006888:Hydroxycholesterols / Q000494:pharmacology; D008077:Lipoproteins, LDL / Q000494:pharmacology; D009131:Muscle, Smooth, Vascular / Q000166:cytology*
D004731:Endotoxins; D005609:Free Radicals; D006888:Hydroxycholesterols; D008077:Lipoproteins, LDL