Pharmacokinetics of propylene glycol after rectal administration.
Propylene glycol is an excipient of various pharmaceutical preparations. The pharmacokinetics after rectal administration are studied, followed by a consideration on local and systemic side-effects for a solution of paracetamol in a mixture of propylene glycol and water. After administration of 8.64 g propylene glycol to 10 adults and 173 mg/kg body weight to 4 children, peak concentrations (Cmax) of 199 mg/l and 171 mg/l respectively were reached (tmax) after 1.5 hr and 1.0 hr. The average terminal half-lives (t1/2) in adults and children were respectively 2.8 hr and 2.6 hr, total body clearance (CI/F) 0.20 l/hr*kg and 0.21 l/h*kg and apparent volume of distribution (VD/F) 0.79 l/kg and 0.77 l/kg.
Kollöffel
W J
WJ
Department of Clinical Pharmacy, Twenteborg Hospital, The Netherlands.
Weekers
L E
LE
Goldhoorn
P B
PB
D000285:Administration, Rectal; D000328:Adult; D019540:Area Under Curve; D002648:Child; D002675:Child, Preschool; D005079:Excipients / Q000008:administration & dosage*; D006207:Half-Life; D006801:Humans; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000008:administration & dosage* / Q000493:pharmacokinetics*
D005079:Excipients; D011409:Propylene Glycols; D019946:Propylene Glycol