Angiotensin II stimulates production of nitric oxide in guinea pig airways via AT1 receptor activation.
Angiotensin II (Ang II) and nitric oxide (NO) regulate a variety of physiological functions. In this study, we suggest that inhaled Ang II produces an initial bronchodilation apparently by stimulating NO production via AT1 receptors. Also, we demonstrate that following the initial bronchodilation, Ang II causes bronchoconstriction in the guinea pig, also via AT1 receptors. Both of the findings are important for our understanding of airway functions induced by Ang II.
Kanazawa
H
H
1st Department of Internal Medicine, Osaka City University Medical School, Japan.
Kurihara
N
N
Hirata
K
K
Fujiwara
H
H
Takeda
T
T
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D001980:Bronchi / Q000187:drug effects* / Q000378:metabolism; D016084:Bronchoconstriction / Q000187:drug effects; D006168:Guinea Pigs; D008297:Male; D019331:NG-Nitroarginine Methyl Ester; D009569:Nitric Oxide / Q000096:biosynthesis*; D011945:Receptors, Angiotensin / Q000187:drug effects* / Q000502:physiology
D011945:Receptors, Angiotensin; D000804:Angiotensin II; D009569:Nitric Oxide; D001120:Arginine; D019331:NG-Nitroarginine Methyl Ester