Axon-Schwann cell interactions regulate the expression of c-jun in Schwann cells.
The transcription factor c-jun is selectively expressed by non-myelinating Schwann cells in normal peripheral nerve, and be "denervated," previously myelinatng Schwann cells, after axotomy. When axons regenerate into the distal nerve-stump, the expression of c-jun declines as Schwann cells remyelinate axons. Treating cultured Schwann cells with forskolin, a drug that mimics many of the effects of axon-Schwann cell interactions, decreases the expression of myelin-specific genes. Overexpressing c-jun in cultured Schwann cells, however, does not decrease the expression of a myelin basic protein promoter-reporter construct, indicating that c-jun expression may not directly regulate myelin-specific gene expression. These data suggest that c-jun is invloved in regulating the phenotype of non-myelinating and denervated Schwann cells.
Shy
M E
ME
Department of Neurology, Wayne State University, Detroit, Michigan, USA.
Shi
Y
Y
Wrabetz
L
L
Kamholz
J
J
Scherer
S S
SS
D000818:Animals; D001369:Axons / Q000502:physiology*; D002450:Cell Communication; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000502:physiology; D003714:Denervation; D008297:Male; D009186:Myelin Sheath / Q000502:physiology; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012583:Schwann Cells / Q000378:metabolism* / Q000502:physiology*; D012584:Sciatic Nerve / Q000254:growth & development / Q000378:metabolism; D018808:Transcription Factor AP-1 / Q000378:metabolism
D016755:Proto-Oncogene Proteins c-jun; D018808:Transcription Factor AP-1; D000242:Cyclic AMP