Treatment of neutropenic oral ulceration in human immunodeficiency virus infection with G-CSF.
We report the novel use of granulocyte colony-stimulating factor in the treatment of severe oral ulceration in human immunodeficiency virus-associated neutropenia. A 38-year-old man with acquired immunodeficiency syndrome developed severe refractory oral aphthous ulceration that persisted for 6 months despite a range of empirical treatments including corticosteroid. Rapid resolution of the ulceration occurred once the neutrophil count was restored to normal with granulocyte colony-stimulating factor.
Luzzi
G A
GA
South Buckinghamshire NHS Trust, Wycombe General Hospital, High Wycombe, U.K.
Jones
B J
BJ
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000328:Adult; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000627:therapeutic use*; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007279:Injections, Subcutaneous; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D009503:Neutropenia / Q000188:drug therapy*; D009504:Neutrophils / Q000473:pathology; D011994:Recombinant Proteins; D013281:Stomatitis, Aphthous / Q000188:drug therapy*
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor