title: [Primary malignant mediastinal germ cell tumor causing pericardial effusion].
abstract: A 19-year-old man presented with chest pain, dyspnea and dry cough. Chest X-ray and computerized tomography showed a large, anterior, mediastinal mass. 2-dimensional echocardiography demonstrated a large amount of pericardial fluid. Serum alpha-fetoprotein was increased. Fine-needle, aspiration cytology during anterior mediastinotomy revealed malignant cells. Anterior thoracotomy demonstrated a large, anterior, mediastinal mass extending into the pericardial sac. The tumor was incompletely resected and 700 ml of pericardial fluid were removed. Histological examination showed a malignant, mixed, germ cell tumor. Cytologic examination of pericardial fluid revealed malignant tumor cells. Postoperatively, combined chemotherapy was administered and 3 years later the patient is free of symptoms.
authors.affiliation: Dept. of Medicine, C Rambam Medical Center, Technion Faculty of Medicine, Haifa.
authors.forename: Y
authors.initials: Y
authors.lastname: Edoute
authors.forename: Y
authors.initials: Y
authors.lastname: Ben-Arie
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001707:Biopsy, Needle; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005047:Etoposide / Q000008:administration & dosage; D005500:Follow-Up Studies; D018237:Germinoma / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D010490:Pericardial Effusion / Q000209:etiology*; D014057:Tomography, X-Ray Computed; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins; D001761:Bleomycin; D005047:Etoposide; D002945:Cisplatin