title: Hypopigmentation in hemodialysis. Acquired hair and skin fairness in a uremic patient undergoing maintenance hemodialysis: case report and review of the literature.
abstract: With recent advances in medicine, uremic patients are living longer with an improving quality of life. Several skin diseases have been reported in patients with chronic renal failure, and the opportunity has been offered to elucidate newer cutaneous abnormalities among patients undergoing long-term hemodialysis. Hyperpigmentation was the most prevalent cutaneous abnormality observed in these patients, but hypopigmentation remains an exceptional event. We report here a case of a maintenance hemodialysis patient with an acquired hair and skin fairness. Although the true mechanism involved in this entity remains obscure, it can be correlated with a disturbance of phenylalanine metabolism on the basis of the current knowledge.
authors.affiliation: Departments of Internal Medicine and Nephrology and of dermatology, H. Chaker Hospital, Sfax, Tunisia.
authors.forename: M B
authors.initials: MB
authors.lastname: Hmida
authors.forename: H
authors.initials: H
authors.lastname: Turki
authors.forename: J
authors.initials: J
authors.lastname: Hachicha
authors.forename: P
authors.initials: P
authors.lastname: Reygagne
authors.forename: D
authors.initials: D
authors.lastname: Rabier
authors.forename: A
authors.initials: A
authors.lastname: Zahaf
authors.forename: A
authors.initials: A
authors.lastname: Jarraya
mesh_terms: D006197:Hair / Q000648:ultrastructure; D006801:Humans; D017496:Hypopigmentation / Q000209:etiology* / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010649:Phenylalanine / Q000378:metabolism; D006435:Renal Dialysis / Q000009:adverse effects*; D012867:Skin / Q000648:ultrastructure
chemical_list: D010649:Phenylalanine