title: [Proposal of new formulas for three-point urea kinetics, compared with traditional kinetics and direct dialysis quantification].
abstract: Classical urea kinetic model (UKM) has been followed by several proposals to determine dialysis adequacy either by direct quantification (DDQ), either by simplified two-points formulas (pre- and post-dialysis BUN), or by mUKM, a modified three-point algorithm (pre-post and pre-next dialysis), where urea distribution volume is input to obtain clearance and urea generation rate. Our new formulas (mUKM2) are derived from urea mass balance, and avoid iterative calculation: their results are similar to those obtained by UKM and mUKM when the standard post-dialysis BUN value is employed. On the contrary, when the equilibrated net-rebound value (Cpwnr) is employed their results are very close to the reference DDQ model: however the new approach is simpler and more practical, to measure dialysis dose taking account of the urea rebound phenomenon.
authors.affiliation: Servizio di Nefrologia e Dialisi, Ospedale, Ivrea, Torino.
authors.forename: G M
authors.initials: GM
authors.lastname: Bosticardo
authors.forename: U
authors.initials: U
authors.lastname: Avalle
authors.forename: A
authors.initials: A
authors.lastname: Serra
authors.forename: F
authors.initials: F
authors.lastname: Giacchino
authors.forename: A
authors.initials: A
authors.lastname: Molino
authors.forename: S
authors.initials: S
authors.lastname: Alloatti
mesh_terms: D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D006435:Renal Dialysis; D014508:Urea / Q000378:metabolism*
chemical_list: D014508:Urea