title: Efficacy of transcutaneous computed tomography--guided fine needle aspiration biopsy in patients with laryngeal squamous cell carcinoma, probable failed radiation therapy, and negative transmucosal biopsies.
abstract: For patients with suspected recurrent/persistent laryngeal squamous cell carcinoma (SCC) after external beam radiotherapy (EBRT), routine transmucosal biopsies obtained during direct laryngoscopy may fail to reveal active carcinoma. We evaluated transcutaneous computed tomography-guided fine needle aspiration (CTGFNA) in three consecutive patients who had a persistently fixed true vocal fold after EBRT that had been administered for laryngeal SCC and who had multiple negative transmucosal laryngeal biopsies. All three CTGFNA biopsies were positive, but final pathology confirmed invasive SCC in only one of the three patients. Despite its theoretical advantages, CTGFNA in its present form requires further assessment and/or modification.
authors.affiliation: Department of Surgery, Section of Otolaryngology, Yale University School of Medicine, New Haven, CN 06520-8041, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Citardi
authors.forename: J J
authors.initials: JJ
authors.lastname: Abrahams
authors.forename: S
authors.initials: S
authors.lastname: Flynn
authors.forename: C T
authors.initials: CT
authors.lastname: Sasaki
mesh_terms: D000368:Aged; D001707:Biopsy, Needle / Q000379:methods; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000532:radiotherapy; D005069:Evaluation Studies as Topic; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D014057:Tomography, X-Ray Computed; D017211:Treatment Failure