Acute myeloid leukaemia with t(8;16)(p11;p13) in a child after intrauterine X-ray exposure.
We describe t(8;16)(p11;p13) acute myeloid leukaemia (AML-M4) in a 12-year-old white male with a history of prenatal X-ray exposure. He had skin and bone involvement and some of the leukaemic blasts showed haemophagocytosis, characteristic features seen in t(8;16) AML. 20% of the reported cases of t(8;16)(p11;p13) AML are therapy-related and this case further supports the possible role of the ionizing radiation in the development of this disorder.
Savaşan
S
S
Children's Hospital of Michigan, Division of Hematology/Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Mohamed
A N
AN
Lucas
D R
DR
Dugan
M C
MC
Ryan
J R
JR
Ravindranath
Y
Y
D000328:Adult; D001466:Barium Sulfate; D002648:Child; D002885:Chromosomes, Human, Pair 16; D002898:Chromosomes, Human, Pair 8; D004733:Enema / Q000009:adverse effects; D005260:Female; D006801:Humans; D007621:Karyotyping; D015479:Leukemia, Myelomonocytic, Acute / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics; D008297:Male; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011297:Prenatal Exposure Delayed Effects; D011859:Radiography / Q000009:adverse effects*; D014178:Translocation, Genetic
D001466:Barium Sulfate