Significantly increased activated T cells are associated with declining CD4 cells in human immunodeficiency virus positive patients.
A cross-sectional study on the expression of 6 lymphocyte markers was carried out on 481 patients with human immunodeficiency virus (HIV) and 79 normals after stratification based on absolute CD4 counts. The data were stratified according to the following groups: (I) 1201 to 1600, (II) 801 to 1200, (III) 401 to 800 and (IV) 0 to 400 (x 10(6) CD4 cells per mm3). The mean percentages of the subsets before stratification showed that HIV patients had increased percentages of CD3+ (75.7 against 66.9), CD3+CD8+ (52.2 against 32.3) and CD3+HLA-DR+ (36.1 against 14.4) cells and lower percentages of CD19 (10.3 against 13.3) and natural killer cells (13.7 against 20.4) when compared to controls in the same group. A definite trend, however, was only seen in CD3+CD8+ (47.4, 50.0, 54.0, 57.5 for groups I, II, III and IV respectively) and CD3+HLA-DR+ (29.1, 32.9, 38.4, 43.9 for groups I, II, III and IV respectively).
Dhaliwal
J S
JS
Division of Immunology, Institute for Medical Research, Kuala Lumpur, Malaysia.
Balasubramaniam
T
T
Quek
C K
CK
Arumainnathan
S
S
Nasuruddin
B A
BA
D018941:Antigens, CD19 / Q000235:genetics; D001402:B-Lymphocytes / Q000473:pathology; D017252:CD3 Complex / Q000235:genetics; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology*; D016827:CD8 Antigens / Q000235:genetics; D018414:CD8-Positive T-Lymphocytes / Q000473:pathology; D003430:Cross-Sectional Studies; D005786:Gene Expression Regulation; D006679:HIV Seropositivity / Q000276:immunology* / Q000473:pathology; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology; D008213:Lymphocyte Activation / Q000276:immunology*; D018655:Lymphocyte Count; D012189:Retrospective Studies; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology
D018941:Antigens, CD19; D017252:CD3 Complex; D016827:CD8 Antigens; D006684:HLA-DR Antigens