Takayasu's arteritis associated with ulcerative colitis; genetic factors in this association.
Both ulcerative colitis and Takayasu's arteritis are though to be organ-specific immune-mediated inflammatory diseases. We present the rare case of a 23-year-old woman with a 4-year history of ulcerative colitis who developed Takayasu's arteritis one month after giving birth. She was found to carry the human leukocyte antigens (HLA)-B52 and DR2, which were previously noted to be associated with these inflammatory conditions in the Japanese population. The pathogenic relevance of this haplotype to the concomitant development of these two conditions is discussed.
Morita
Y
Y
Third Department of Internal Medicine, Okayama University Medical School.
Yamamura
M
M
Suwaki
K
K
Mima
A
A
Ishizu
T
T
Hirohata
M
M
Kashihara
N
N
Makino
H
H
Ota
Z
Z
D000328:Adult; D003093:Colitis, Ulcerative / Q000150:complications* / Q000235:genetics* / Q000473:pathology; D005260:Female; D015235:HLA-B Antigens / Q000235:genetics; D059950:HLA-B52 Antigen; D015802:HLA-DR2 Antigen / Q000235:genetics; D006801:Humans; D011247:Pregnancy; D013625:Takayasu Arteritis / Q000150:complications* / Q000235:genetics* / Q000276:immunology
D015235:HLA-B Antigens; D059950:HLA-B52 Antigen; D015802:HLA-DR2 Antigen