title: A note on assessing the superiority of a combination drug with a specific alternative.
abstract: This paper describes a new statistical test for evaluating the efficacy of a combination therapy. This procedure is conservative and makes use of prior information in an attempt to improve power for a specific prespecified alternative. The power of this procedure is substantially greater than that of the min test when the effects of the components are equal or nearly equal and are accurately predicted. This procedure could be of value for evaluating combinations of well-studied drugs.
authors.affiliation: Merck Research Laboratory, Blue Bell, Pennsylvania, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Snapinn
authors.forename: S K
authors.initials: SK
authors.lastname: Sarkar
mesh_terms: D003627:Data Interpretation, Statistical; D004359:Drug Therapy, Combination; D006801:Humans; D008432:Mathematical Computing