Effect of immunomodulation with galactoside-specific mistletoe lectin on experimental listeriosis.
BALB/c-mice (n = 10 per experimental group) were intravenously infected with 5 x 10(4) and 5 x 10(5) viable cells of Listeria monocytogenes SLCC 4013. About 50-80 h after this challenge, all mice of the untreated control groups succumbed to their infection. Pretreatment of experimental animals on the optimal immunoactive schedule with the galactoside-specific mistletoe lectin (ML-1; 1 ng/kg body weight; days 1, 4, 5, 6 before challenge), however, evidently reduced the lethality of listerial infection (survival rate 60%).
Stoffel
B
B
Institute of Medical Microbiology and Hygiene, University of Cologne, Germany.
Beuth
J
J
Pulverer
G
G
D000818:Animals; D004195:Disease Models, Animal; D005697:Galactosides / Q000737:chemistry*; D037102:Lectins / Q000494:pharmacology*; D008089:Listeria monocytogenes; D008088:Listeriosis / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D014784:Mistletoe / Q000378:metabolism*; D037121:Plant Lectins; D028321:Plant Preparations; D010940:Plant Proteins; D010946:Plants, Medicinal; D054790:Ribosome Inactivating Proteins, Type 2; D014118:Toxins, Biological / Q000494:pharmacology*
D005697:Galactosides; D037102:Lectins; D037121:Plant Lectins; D028321:Plant Preparations; D010940:Plant Proteins; D054790:Ribosome Inactivating Proteins, Type 2; D014118:Toxins, Biological; C009674:ribosome inactivating protein, Viscum