title: [Two patients with acute promyelocytic leukemia whose relapse was noted by cytodiagnosis of middle ear discharge].
abstract: Patient 1 was a 36-year-old male and diagnosed as APL in April 1989, and treated with BHAC-DMP and BHAC-AMP. In January 1990, a diagnosis of exudative otitis media was made, but intractable. In June, left facial paralysis appeared and cytodiagnosis of the discharge from the middle ear confirmed leukemic cells. Otitis media and facial paralysis improved after high dose Ara-C, but developed again 5 months later. The condition improved after high dose Ara-C and irradiation of the temporal bones. In September 1992, he died of recurrence but no aggravation in facial paralysis or otitis media. Patient 2 was a 24-year-old female and diagnosed as APL in July 1989, and treated with BHAC-DMP. In May 1990, exudative otitis media was appeared. In July, recurrence was observed but improved by high dose Ara-C. In October, otitis media was aggravated again, and cytodiagnosis confirmed leukemic cell infiltration. She was treated with high dose Ara-C and irradiation of the temporal bones, then achieved complete remission. Maintenance therapy was continued until August 1992, she has been alive. When exudative otitis media developed during the course of leukemia, cytodiagnosis of the discharge from the middle ear should be performed. High dose Ara-C and irradiation of the temporal bone were effective.
authors.affiliation: Department of Laboratory Medicine, Chiba University School of Medicine.
authors.forename: K
authors.initials: K
authors.lastname: Kikuno
authors.forename: S
authors.initials: S
authors.lastname: Goto
authors.forename: H
authors.initials: H
authors.lastname: Iwasaki
authors.forename: T
authors.initials: T
authors.lastname: Saotome
authors.forename: A
authors.initials: A
authors.lastname: Takeshita
authors.forename: F
authors.initials: F
authors.lastname: Nagamura
authors.forename: J
authors.initials: J
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Tsujimura
authors.forename: T
authors.initials: T
authors.lastname: Iseki
authors.forename: H
authors.initials: H
authors.lastname: Yonemitu
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003581:Cytodiagnosis; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology* / Q000628:therapy; D008297:Male; D009361:Neoplasm Invasiveness; D010034:Otitis Media with Effusion / Q000473:pathology*; D012074:Remission Induction; D012888:Skull Neoplasms / Q000473:pathology*; D013701:Temporal Bone