[Action of triterpene glycosides of the dammarane series and their aglycones on lipid membranes].
The action of the dammarane triterpene glycosides Rb1 and Rg1 and their aglycones 20(S) protopanaxatriole and 20(S) protopanaxadiole from Korean ginseng on permeability of bilayer lipid membranes formed of monolayers was studied. RgI, protopanaxatriole and protopanaxadiole in concentrations of 3, 0.5 and 30 micrograms/ml respectively formed single ionic channels in the water phase on the membrane side containing cholesterol. The channel conductivity was 5 to 30 pSm in 1 M KCl. The ionic channels were more selective with respect to K+ as compared to Cl-. Rb1 was also able to increase the conductivity of the lipid membranes. However, no jumps in the current characteristics of the single channels were detected. All the substances in high concentrations on one side of the membrane independently of the cholesterol content induced fluctuation of the high amplitude current (from several tens of pSm to several hundreds of nSm).
Abdrasilov
B S
BS
Institute of Ginseng and Tobacco, Taejon, Korea.
Elemesov
R E
RE
Kim
Iu A
IuA
Pak Khva Din
D004365:Drugs, Chinese Herbal; D004553:Electric Conductivity; D036145:Ginsenosides; D007473:Ion Channels / Q000187:drug effects; D008051:Lipid Bilayers; D005894:Panax / Q000737:chemistry*; D010946:Plants, Medicinal; D012502:Sapogenins / Q000302:isolation & purification; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D007473:Ion Channels; D008051:Lipid Bilayers; D012502:Sapogenins; D012503:Saponins; D014315:Triterpenes; C081552:protopanaxatriol; C062916:protopanaxadiol; C035054:ginsenoside Rg1