[A case of successful management of advanced cholangiocellular carcinoma by repeated hepatic resection].
A 50-year-old woman with advanced cholangiocellular carcinoma (CCC) underwent extended left hepatectomy and catheterization into the hepatic artery. Following the procedure, intra-arterial infusion chemotherapy of the fluorouracil (5-FU) was performed. This chemotherapy was given 13 times at 2,500 mg for 10 months, so the total dose of 5-FU was 32.5 g. About two years after the operation, the patient underwent hepatic resection again for solitary recurrence of CCC. The prognosis of CCC is very poor. Aggressive surgical resection may be the only method to assure a good outcome. However, the survival rate after curative resection has been low. Adjuvant hepatic arterial infusion chemotherapy after surgery may be effective for a good prognosis.
Nakano
H
H
Dept. of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases.
Sasaki
Y
Y
Imaoka
S
S
Furukawa
H
H
Ishikawa
O
O
Kabuto
T
T
Kameyama
M
M
Hiratsuka
M
M
Ohigashi
H
H
Nakamori
S
S
Yasuda
T
T
Iwanaga
T
T
D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D001650:Bile Duct Neoplasms / Q000188:drug therapy / Q000601:surgery*; D001653:Bile Ducts, Intrahepatic; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000601:surgery*; D018281:Cholangiocarcinoma / Q000188:drug therapy / Q000601:surgery*; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006498:Hepatectomy; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy / Q000601:surgery*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil