Alpha-tocopherol ameliorates cyclophosphamide-induced hyperlipidemia in fibrosarcoma-bearing rats.
Cyclophosphamide, an alkylating agent, is currently being used for the treatment of various types of cancer, either alone or in combination with other cytostatic drugs. However, cyclophosphamide has a detrimental effect on lipid metabolism and causes hyperlipidemia in patients. Since alpha-tocopherol is known to reduce hyperlipidemia, we have investigated the effects of adding alpha-tocopherol to the cyclophosphamide treatment. Our study, carried out on fibrosarcoma-bearing rats, shows that alpha-tocopherol markedly reduces cyclophosphamide-induced hyperlipidemia and brings lipid metabolism down to values observed in untreated controls.
Ilanchezhian
S
S
Department of Medical Biochemistry, University of Madras, Taramani Campus, India.
Thangaraju
M
M
Sasirekha
S
S
Sachdanandam
P
P
D000818:Animals; D002784:Cholesterol / Q000097:blood; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors* / Q000633:toxicity; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005354:Fibrosarcoma / Q000097:blood*; D006949:Hyperlipidemias / Q000139:chemically induced / Q000517:prevention & control*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010743:Phospholipids / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood; D014810:Vitamin E / Q000494:pharmacology*
D005230:Fatty Acids, Nonesterified; D008055:Lipids; D010743:Phospholipids; D014280:Triglycerides; D014810:Vitamin E; D003520:Cyclophosphamide; D002784:Cholesterol