Intact coding region of the serotonin transporter gene in obsessive-compulsive disorder.
Epidemiologic studies indicate that obsessive-compulsive disorder is genetically transmitted in some families, although no genetic abnormalities have been identified in individuals with this disorder. The selective response of obsessive-compulsive disorder to treatment with agents which block serotonin reuptake suggests the gene coding for the serotonin transporter as a candidate gene. The primary structure of the serotonin-transporter coding region was sequenced in 22 patients with obsessive-compulsive disorder, using direct PCR sequencing of cDNA synthesized from platelet serotonin-transporter mRNA. No variations in amino-acid sequence were found among the obsessive-compulsive disorder patients or healthy controls. These results do not support a role for alteration in the primary structure of the coding region of the serotonin-transporter gene in the pathogenesis of obsessive-compulsive disorder.
Altemus
M
M
Laboratory of Clinical Science, NIMH, NIH, Bethesda, Maryland 20892-1264, USA.
Murphy
D L
DL
Greenberg
B
B
Lesch
K P
KP
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism; D002352:Carrier Proteins / Q000096:biosynthesis / Q000097:blood / Q000235:genetics*; D018076:DNA, Complementary; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000097:blood / Q000235:genetics*; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D009771:Obsessive-Compulsive Disorder / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000097:blood; D050486:Serotonin Plasma Membrane Transport Proteins
D002352:Carrier Proteins; D018076:DNA, Complementary; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins