[The use of low dose midazolam for the management of spinal anesthesia].
The present study was designed to evaluate the effects of low dose midazolam (MZ) on memories and ease of management of spinal anesthesia. MZ was administered to 103 patients (ASA 1-2), of whom 50 patients were premedicated with atropine sulfate 0.5mg and pethidine hydrochloride (group P), with 53 patients receiving no premedication (group nP). A double blind randomized trial was conducted with the dose of MZ (0, 0.01, 0.02, 0.04, 0.08 mg.kg-1), and MZ was administered i.v. to patients just prior to spinal puncture. The short-term and long-term memories were impaired after administration of MZ in both groups. But the recovery from impairment of memories was more rapid in the short-term memory than in the long-term memory, suggesting that MZ impairs mainly the acquisition of memories. A dose-dependent decrease in SpO2 was observed in group P. We conclude that MZ is a useful drug to relieve anxiety of patients during surgery, but it accompanies the risk of respiratory depression.
Nagahama
H
H
Department of Anesthesiology, St. Marianna University School of Medicine, Kawasaki, Japan.
Kikuchi
S
S
Shimazaki
K
K
Tateda
T
T
Aoki
T
T
Takahashi
K
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D000775:Anesthesia, Spinal; D014151:Anti-Anxiety Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D007275:Injections, Intravenous; D008568:Memory / Q000187:drug effects; D008874:Midazolam / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D008875:Middle Aged; D011229:Preanesthetic Medication; D012120:Respiration Disorders / Q000139:chemically induced
D014151:Anti-Anxiety Agents; D008874:Midazolam