title: Subacute pancerebellar syndrome associated with systemic lupus erythematosus.
abstract: A pancerebellar syndrome of subacute progression associated with cerebellar atrophy is highly suggestive of a paraneoplastic cerebellar degeneration (PCD). We describe a 27-year-old woman with systemic lupus erythematosus (SLE) that presented with a subacute pancerebellar syndrome. Serum and CSF anti-Yo, anti-Hu and anti-Ri antibodies were not found neither in blood, nor in CSF. Brain MRI showed a cerebellar atrophy. The cerebellar ataxia improved markedly following corticosteroids administration. This case probably demonstrates that an antineuronal antibody negative subacute cerebellar disease may not only be a manifestation of paraneoplastic disease, but that it can also be associated with SLE.
authors.affiliation: Service de Neurologie, Hôpital Erasme, Bruxelles, Belgium.
authors.forename: M U
authors.initials: MU
authors.lastname: Manto
authors.forename: P
authors.initials: P
authors.lastname: Rondeaux
authors.forename: J
authors.initials: J
authors.lastname: Jacquy
authors.forename: J G
authors.initials: JG
authors.lastname: Hildebrand
mesh_terms: D000328:Adult; D002526:Cerebellar Diseases / Q000473:pathology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D013577:Syndrome