Transgenic and knockout mice in the study of neurodegenerative diseases.
Accurate animal models are essential for detailed analysis of the mechanisms underlying human neurodegenerative diseases. In addition, they can offer useful paradigms for the development and evaluation of new therapeutic strategies. We review the most popular techniques for modification of the mammalian genome in vivo, and provide a critical evaluation of the available transgenic mouse models for several neurological conditions of humans, including prion diseases, human retroviral diseases, Alzheimer's disease, and motor neuron diseases.
Aguzzi
A
A
Institute of Neuropathology, Department of Pathology, Zürich.
Brandner
S
S
Marino
S
S
Steinbach
J P
JP
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009410:Nerve Degeneration; D009422:Nervous System Diseases