[Transverse lesion of the spinal cord due to mucormycosis in an AML patient].
A 54 year old man complained exertional dyspnea and palpitation since November 1989. As he was diagnosed with marked anemia, leukocytosis and thrombocytopenia by his work place doctor, he was admitted to our hospital. Acute myelogenous leukemia was diagnosed based on laboratory findings. BHAC-DMP, BHAC-MEP and A triple V therapies were only partially effective. Fine nodular shadows in all lung fields and a semicircular mass in the right lower lobe next to the thoracic vertebra were evident on the chest X-P since the end of March 1990. He was treated with antibiotics and amphotericin B but the abnormal lung shadows did not disappear. He had sudden onset of paraplegia and loss of all sensation below Th6 on May 1. Aparavertebral mass in the right lower lobe was detected by CT and MRI, for which radiotherapy was performed but without improvement. He died of respiratory failure on May 12. Autopsy showed that the semicircular paravertebral mass continued to the main pulmonary vein and epidural area of the thoracic cord (Th6-8). Microscopically, mucormycosis was found. Necrosis due to mucor embolism was found in the thoracic cord. It is usually difficult to diagnose mucormycosis in immunocompromised patients while they are alive. It is important to suspect mucormycosis if any infarction symptoms or infections resistant to antibiotics develop in immunocompromised patients.
Suzuki
G
G
Third Department of Internal Medicine, Hokkaido University School of Medicine.
Kurosawa
M
M
Takanashi
Y
Y
Itaya
T
T
Kunieda
Y
Y
Maeda
S
S
Okabe
M
M
Asaka
M
M
Miyazaki
T
T
D017809:Fatal Outcome; D006801:Humans; D016867:Immunocompromised Host; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008168:Lung / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000150:complications / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis; D009188:Myelitis, Transverse / Q000150:complications* / Q000382:microbiology* / Q000473:pathology; D009894:Opportunistic Infections / Q000150:complications*; D013116:Spinal Cord / Q000473:pathology