title: Immunohistochemical study of pancreatic neuroendocrine tumor in Panthera tigris tigris.
abstract: The histological and immunohistochemical characteristics of a case of pancreatic neuroendocrine tumor are described in a 14-yr-old female Bengal tiger (Panthera tigris tigris) housed at the New Biblical Zoo of Jerusalem, Jerusalem, Israel, 1994. The neoplastic cells were immunohistochemically negative for insulin and glucagon, slightly positive for neuron-specific enolase, moderately positive for serotonin and somatostatin, and markedly positive for chromogranine A and gastrin. This is the first documentation of a pancreatic neuroendocrine tumor in the tiger.
authors.affiliation: Department of Pathology, Kimron Veterinary Institute, Bet-Dagan, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Nyska
authors.forename: J
authors.initials: J
authors.lastname: Goldstein
authors.forename: G
authors.initials: G
authors.lastname: Eshkar
authors.forename: B
authors.initials: B
authors.lastname: Klein
mesh_terms: D000818:Animals; D002335:Carnivora; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis; D005260:Female; D005755:Gastrins / Q000032:analysis; D005934:Glucagon / Q000032:analysis; D007150:Immunohistochemistry; D007328:Insulin / Q000032:analysis; D018358:Neuroendocrine Tumors / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D012701:Serotonin / Q000032:analysis; D013004:Somatostatin / Q000032:analysis
chemical_list: D053379:Chromogranin A; D002864:Chromogranins; D005755:Gastrins; D007328:Insulin; D012701:Serotonin; D013004:Somatostatin; D005934:Glucagon; D010751:Phosphopyruvate Hydratase