title: Prenatal diagnosis of diffuse mesangial glomerulosclerosis by ultrasonography: a longitudinal study of a case in an affected family.
abstract: The 4th child of an Arabian consanguineous family with 2 previous infant deaths due to diffuse mesangial glomerulosclerosis (at the ages of 1 and 44 days) and 1 healthy 3-year old child was followed up by ultrasonography from the 9th until the 35th week of gestation. Ultrasound showed enlarged hyperechogenic kidneys from the 14th week onwards, and the amniotic fluid level was increased to the upper normal limit. An amniocentesis at 14+ weeks of gestation showed a normal male karyotype and normal alpha-fetoprotein levels in amniotic fluid and maternal serum. Albumin and alpha 1-microglobulin levels in the amniotic fluid were within the normal range and not useful for diagnostic purposes. The child was born at the 36th week of gestation and died of renal failure 21 days later. A postmortem renal biopsy specimen revealed diffuse mesangial glomerulosclerosis.
authors.affiliation: Department of Gynecology and Obstetrics, Humboldt University, Berlin, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Hofstaetter
authors.forename: I
authors.initials: I
authors.lastname: Neumann
authors.forename: T
authors.initials: T
authors.lastname: Lennert
authors.forename: J W
authors.initials: JW
authors.lastname: Dudenhausen
mesh_terms: D000328:Adult; D018912:Arabs; D003241:Consanguinity; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications / Q000151:congenital / Q000000981:diagnostic imaging* / Q000208:ethnology; D010375:Pedigree; D011247:Pregnancy; D051437:Renal Insufficiency / Q000209:etiology; D016216:Ultrasonography, Prenatal