title: Abstinence symptomatology associated with cessation of chronic cocaine abuse among methadone-maintained patients.
abstract: We assessed cocaine abstinence symptomatology in a sample of 100 cocaine-abusing, methadone-maintained patients who completed an anonymous questionnaire retrospectively rating the intensity of 18 symptoms at six time points, from 30 minutes to 2 weeks, post-cocaine use. We found that a majority of patients endorsed symptoms related to dysphoria 24 hours post-binge. However, these symptoms tended to be mild to moderate in intensity and relatively short-lived. Principal components analyses extracted four factors accounting for 64% of the variance: psychoticism, exhaustion, agitation, recovery. Early post-binge period was dominated by psychoticism and agitation, followed by recovery for the duration of the period assessed.
authors.affiliation: Department of Psychiatry Yale University School of Medicine, New Haven, Connecticut 06519, USA.
authors.forename: A
authors.initials: A
authors.lastname: Margolin
authors.forename: S K
authors.initials: SK
authors.lastname: Avants
authors.forename: T R
authors.initials: TR
authors.lastname: Kosten
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003042:Cocaine; D000431:Ethanol; D005260:Female; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use*; D013375:Substance Withdrawal Syndrome / Q000523:psychology; D019966:Substance-Related Disorders / Q000188:drug therapy* / Q000523:psychology; D013997:Time Factors
chemical_list: D000431:Ethanol; D003042:Cocaine; D008691:Methadone