title: Pharmacological characterization of glial cell line-derived neurotrophic factor (GDNF): implications for GDNF as a therapeutic molecule for treating neurodegenerative diseases.
abstract: This review presents a comprehensive survey of the recently described pharmacological activities of glial cell line-derived neurotrophic factor on the central nervous system.
authors.affiliation: AMGEN Inc., Department of Neuroscience, MC 5-1-C, 1840 de Havilland Drive, Thousand Oaks, CA 91320-1789, USA. plapchak@amgen.com
authors.forename: P A
authors.initials: PA
authors.lastname: Lapchak
authors.forename: S
authors.initials: S
authors.lastname: Jiao
authors.forename: P J
authors.initials: PJ
authors.lastname: Miller
authors.forename: L R
authors.initials: LR
authors.lastname: Williams
authors.forename: V
authors.initials: V
authors.lastname: Cummins
authors.forename: G
authors.initials: G
authors.lastname: Inouye
authors.forename: C R
authors.initials: CR
authors.lastname: Matheson
authors.forename: Q
authors.initials: Q
authors.lastname: Yan
mesh_terms: D000818:Animals; D051100:Glial Cell Line-Derived Neurotrophic Factor; D006801:Humans; D009410:Nerve Degeneration / Q000187:drug effects*; D009414:Nerve Growth Factors / Q000494:pharmacology*; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D009422:Nervous System Diseases / Q000188:drug therapy*; D018696:Neuroprotective Agents / Q000494:pharmacology*
chemical_list: C495039:GDNF protein, human; D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D018696:Neuroprotective Agents