Difinite-sequenced oligonucleotides shackled with tetraphenylporphyrin: syntheses and properties.
Oligonucleotides shackled with tetraphenylporphyrin at internucleotide phosphodiester linkage were synthesized and their properties were investigated. The derivatives can hybridize with the complementary oligonucleotide completely. Introduction of porphyrin into the oligonucleotide has little effect on the helix structure and hybridization entirely changes the electronic environment of the porphyrin moiety. Therefore, it is expected that the derivatives locate the photoactive phosphorus(V)porphyrin moiety in close proximity to the target site of DNA.
Nomura
A
A
Division of Molecular Engineering, Graduate School of Engineering, Kyoto University, Japan.
Morimoto
M
M
Fukui
K
K
Segawa
H
H
Shimidzu
T
T
D001483:Base Sequence; D001665:Binding Sites; D002942:Circular Dichroism; D004563:Electrochemistry; D015394:Molecular Structure; D009691:Nucleic Acid Denaturation; D009693:Nucleic Acid Hybridization; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D010777:Photochemistry; D011166:Porphyrins / Q000737:chemistry
D009838:Oligodeoxyribonucleotides; D011166:Porphyrins