title: [Pneumocystis carinii pneumonia in a HTLV-I carrier with monoclonal proliferation of HTLV-I infected lymphocyte].
abstract: A 63-year-old woman had Pneumocystis carinii pneumonia without any apparent underlying disease such as cancers or HIV infection. Although she reacted positively for HTLV-I antibody, hematological findings and clinical symptoms did not suggest that this patient had an ATL. Southern blot analysis revealed that HTLV-I infected lymphocytes had already proliferated monoclonally. The development of overt ATL should be carefully monitored in this type of patient as Pneumocystis carinii infection in HTLV-I carriers were reported to be a predictive sign of ATL and the monoclonal integration of a HTLV-I genome in the lymphocytes in this patient also suggests the presence of neoplastic clone.
authors.affiliation: Department of Internal Medicine, Kagoshima City Hospital.
authors.forename: N
authors.initials: N
authors.lastname: Kawahigashi
authors.forename: Y
authors.initials: Y
authors.lastname: Furukawa
authors.forename: M
authors.initials: M
authors.lastname: Tara
authors.forename: K
authors.initials: K
authors.lastname: Niina
mesh_terms: D015139:Blotting, Southern; D002353:Carrier State; D005260:Female; D015481:HTLV-I Antibodies / Q000032:analysis; D015490:HTLV-I Infections / Q000150:complications*; D015368:Human T-lymphotropic virus 1; D006801:Humans; D008214:Lymphocytes / Q000821:virology; D008232:Lymphoproliferative Disorders / Q000821:virology*; D008875:Middle Aged; D011020:Pneumonia, Pneumocystis / Q000150:complications*
chemical_list: D015481:HTLV-I Antibodies