title: A comparison of two oximes (HI-6 and obidoxime) for 2-dimethylaminoethyl-(dimethylamido)-phosphonofluoridate poisoning.
abstract: The effects of HI-6 (1-[[[(4-aminocarbonyl) pyridinio]methoxy] methyl]-2-(hydroxyimino)-methyl]pyridinium dichloride monohydrate) on the organophosphorus agent 2-dimethylaminoethyl-(dimethylamido)-phosphonofluoridate (GV) inhibited cholinesterases in blood, brain and diaphragm and the stressogenic effect of GV in rats were compared to the effects of obidoxime. In GV-poisoned rats, HI-6 had a significantly higher reactivating effect in blood and brain as well as diaphragm than had obidoxime. HI-6 also practically eliminated the stressogenic effect of the GV compound. On the other hand, hypercorticosteronaemia and increase of liver tyrosine aminotransferase activity during treatment of poisoning with obidoxime were observed. These findings demonstrate the importance of HI-6 for treatment of GV agent poisoning in rats.
authors.affiliation: Purkynĕ Military Medical Academy, Hradec Králové, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Kassa
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D001921:Brain / Q000201:enzymology; D002802:Cholinesterases / Q000097:blood; D003345:Corticosterone / Q000097:blood; D003964:Diaphragm / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D009768:Obidoxime Chloride / Q000627:therapeutic use*; D062025:Organophosphate Poisoning; D009943:Organophosphorus Compounds / Q000008:administration & dosage / Q000737:chemistry; D010091:Oximes; D011726:Pyridinium Compounds / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014444:Tyrosine Transaminase / Q000378:metabolism
chemical_list: D000931:Antidotes; D009943:Organophosphorus Compounds; D010091:Oximes; D011726:Pyridinium Compounds; C077129:2-dimethylaminoethyl(dimethylamido)phosphonofluoridate; D009768:Obidoxime Chloride; D014444:Tyrosine Transaminase; D000110:Acetylcholinesterase; D002802:Cholinesterases; C022870:asoxime chloride; D003345:Corticosterone