[Tissue levels of EGF and collagen in ovaries of women].
Tissue EGF concentration as well as collagen content were investigated in ovarian homogenates from both menstruating and menopausal women. EGF concentration was found to be higher, but not significant, in postmenopausal women, whereas total collagen as well as forms soluble in acetic acid and in this acid with pepsin were slightly higher in women with normal menstrual cycle. There were statistically significant negative correlations between above mentioned forms of collagen as well as ovarian EGF concentration in this group of patients. The potential role of epidermal growth factor in modulation of ovarian function and extracellular matrix remodelling within human ovary is discussed.
Postawski
K
K
II Kliniki Ginekologii Operacyjnej AM w Lublinie.
Rechberger
T
T
Miturski
R
R
Donica
H
H
Jakowicki
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003094:Collagen / Q000378:metabolism*; D004815:Epidermal Growth Factor / Q000378:metabolism*; D005260:Female; D006801:Humans; D008593:Menopause / Q000378:metabolism*; D008598:Menstruation / Q000378:metabolism*; D008875:Middle Aged; D010053:Ovary / Q000378:metabolism*; D012016:Reference Values
D004815:Epidermal Growth Factor; D003094:Collagen