[Correction of the immunomodulating action of antibiotics in health and in staphylococcal infection].
Administration of tocopherol acetate and essentiale to healthy animals not treated with antibiotics had no effect on the immune response induced by SRBC or LPS of Salmonella typhi. Administration of tocopherol acetate to the mice treated with streptomycin or gentamicin increased the response only to SRBC. Essentialle stimulated the development of the T-dependent and T-independent immune response in the animals treated with benzylpenicillin, streptomycin or gentamicin. Benzylpenicillin and streptomycin increased the suppressing effect of the Staphylococcus infection. Gentamicin had no effect on the immune response to SRBC and LPS. Tocopherol acetate and lysozyme increased the immune response to SRBC. Terrilitin did not influence the immune response to SRBC and LPS. Essentiale stimulated the response to both the T-dependent and T-independent antigens.
Prokopenko
L G
LG
Siplivaia
L E
LE
Lazarev
A I
AI
Shevtsova
E M
EM
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000681:Amylases / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000917:Antibody Formation / Q000187:drug effects; D004338:Drug Combinations; D005839:Gentamicins / Q000627:therapeutic use; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009113:Muramidase / Q000494:pharmacology; D010400:Penicillin G / Q000627:therapeutic use; D010406:Penicillins / Q000627:therapeutic use; D010447:Peptide Hydrolases / Q000494:pharmacology; D010713:Phosphatidylcholines / Q000494:pharmacology; D012016:Reference Values; D013203:Staphylococcal Infections / Q000188:drug therapy*; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives / Q000494:pharmacology; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D005839:Gentamicins; D010406:Penicillins; D010713:Phosphatidylcholines; C011246:essential 303 forte; D014810:Vitamin E; C009402:amylase, phosphates, proteases drug combinations; D000681:Amylases; D009113:Muramidase; D010447:Peptide Hydrolases; D024502:alpha-Tocopherol; D010400:Penicillin G; D024505:Tocopherols