title: The type I interleukin-1 receptor mediates fever in the rat as shown by interleukin-1 receptor subtype selective ligands.
abstract: The interleukin-1 (IL-1) system possesses two distinct receptors (type I and type II) which, together with the accessory protein, mediate a multitude of responses to IL-1 alpha and IL-1 beta, including fever. So far, no receptor subtype-specific ligands have been described. Since both types of IL-1 receptors occur in the thermoregulatory areas it was unclear which IL-1 receptor type mediates fever. We report here that for a series of deletion mutants of human recombinant IL-1 beta (hrIL-1 beta), the affinity of these ligands for the type I IL-1 receptor correlates with their efficacy to evoke the fever response (hrIL-1 beta > des-SND52-54 > des-QGE48-50 > des-I56). Thus, the results suggest that agonist occupancy of the type I IL-1 receptor is essential for IL-1 beta-mediated fever.
authors.affiliation: Department of Neurochemistry and Neurotoxicology, Stockholm University, Sweden.
authors.forename: D
authors.initials: D
authors.lastname: Malinowsky
authors.forename: Z
authors.initials: Z
authors.lastname: Chai
authors.forename: J
authors.initials: J
authors.lastname: Bristulf
authors.forename: A
authors.initials: A
authors.lastname: Simoncsits
authors.forename: T
authors.initials: T
authors.lastname: Bartfai
mesh_terms: D000818:Animals; D005334:Fever / Q000139:chemically induced / Q000235:genetics / Q000503:physiopathology*; D017353:Gene Deletion; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics / Q000494:pharmacology*; D007457:Iodine Radioisotopes; D008024:Ligands; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D017472:Receptors, Interleukin-1 / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: D007375:Interleukin-1; D007457:Iodine Radioisotopes; D008024:Ligands; D017472:Receptors, Interleukin-1; D011994:Recombinant Proteins