Endogenous zinc concentrations in cysteamine-induced duodenal ulcers in the rat.
Exogenously administered zinc compounds have been shown to possess anti-ulcer activity against a wide variety of ulcerogenic agents, both in laboratory animal models and in human peptic ulcer disease. However, a strong possibility exists that endogenous zinc may also play an important role during noxious events by various mechanisms. Therefore, the aim of this study was to focus on the changes of endogenous zinc serum and tissue concentrations in cysteamine-induced duodenal lesions. We used atomic absorption spectrophotometry to determine the tissue and serum concentrations of zinc in normal (control) rats and those with cysteamine-induced duodenal ulcers. The results obtained in this study indicated that the onset, development and spontaneous healing of ulcer lesions were associated with certain shifts in zinc serum and tissue concentrations. Prior to ulcer formation, a significant increase was noted in serum zinc values. With the onset of duodenal lesions, zinc serum concentrations significantly decreased, while there was a significant increase in duodenal tissue concentrations when compared to healthy control animals. Zinc tissue concentrations decreased and returned to starting values by the end of the first week of spontaneous healing. This decrease in zinc tissue concentration corresponded to the healing rate of the duodenal ulcers. Serum zinc concentrations also returned to starting values within the first week period. These observations indicate and confirm that zinc could play an important role in duodenal ulcer disease and represent a natural defense system in the body.
Troskot
B
B
Department of Gastroenterology, University Hospital Sestre Milosrdnice, Medical School, University of Zagreb, Croatia.
Simicevic
V N
VN
Dodig
M
M
Rotkvic
I
I
Ivankovic
D
D
Duvnjak
M
M
D000818:Animals; D003543:Cysteamine / Q000633:toxicity; D004381:Duodenal Ulcer / Q000097:blood / Q000139:chemically induced / Q000378:metabolism*; D005260:Female; D006801:Humans; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014018:Tissue Distribution; D014945:Wound Healing / Q000502:physiology; D015032:Zinc / Q000097:blood / Q000378:metabolism*
D003543:Cysteamine; D015032:Zinc