title: Amelioration of experimental systemic lupus erythematosus (SLE) by retrovirus infection.
abstract: Experimental SLE can be induced in susceptible 129/J mice by immunization with a human anti-DNA antibody bearing a common idiotype designated 16/6 Id. Immunized mice develop autoantibodies, leukopenia, proteinuria, and immune complex deposits in renal glomeruli. Case reports have described clinical improvement in SLE in individuals becoming infected with HIV-1. Because 129/J mice are susceptible to experimental SLE and to infection with the BM5def murine leukemia virus (MuLV) mixture but do not develop the lymphoproliferative/ immunodeficiency disorder known as murine AIDS (MAIDS), we superimposed this infection on immunization with the 16/6 Id. Multiple effects were observed. First, we noted an amelioration in the course of experimental SLE. Second, both in experimental SLE and in BM5def MuLV infection, immunoreactivity to HIV-1 gp120 was demonstrated, although gp120 is not present in the BM5def MuLV viruses. Third, production of autoantibodies characteristically found in SLE, e.g., anti-DNA, anti-RNP, and anti-SSA, was seen in BM5def MuLV-infected mice, demonstrating that an immune response as a consequence of infection had occurred despite the absence of MAIDS induction. We conclude that (1) retrovirus inoculation may ameliorate the course of experimental SLE; and (2) retrovirus inoculation, even in the absence of MAIDS induction, induces an immunologic response which promotes the production of potentially pathogenic autoantibodies.
authors.affiliation: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20893, USA.
authors.forename: B B
authors.initials: BB
authors.lastname: Mittleman
authors.forename: H C
authors.initials: HC
authors.lastname: Morse
authors.forename: S M
authors.initials: SM
authors.lastname: Payne
authors.forename: G M
authors.initials: GM
authors.lastname: Shearer
authors.forename: E
authors.initials: E
authors.lastname: Mozes
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis; D001323:Autoantibodies / Q000096:biosynthesis / Q000187:drug effects; D005260:Female; D015699:HIV Envelope Protein gp120 / Q000097:blood; D007150:Immunohistochemistry; D007668:Kidney / Q000276:immunology; D007970:Leukopenia / Q000209:etiology; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000209:etiology / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D016183:Murine Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology; D012192:Retroviridae Infections / Q000150:complications* / Q000276:immunology
chemical_list: D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D015699:HIV Envelope Protein gp120