Effect of pO2 and pH on synergy of tazobactam and beta-lactam antibiotics against beta-lactamase producing Enterobacteriaceae.
Synergy between tazobactam and ceftriaxone or piperacillin against beta-lactamase producing Enterobacteriaceae was not influenced by the presence or absence of oxygen. For most strains synergy was excellent at neutral pH but reduced in acidic conditions. Low pH increased 50% of the MICs up to or beyond the sensitivity breakpoint.
König
C
C
Department of Medicine, University Hospital, Zürich, Switzerland.
Blaser
J
J
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004357:Drug Synergism; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D010100:Oxygen / Q000494:pharmacology*; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D000078142:Tazobactam; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000096:biosynthesis
D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D065093:beta-Lactamase Inhibitors; D010397:Penicillanic Acid; D001618:beta-Lactamases; D010100:Oxygen; D000078142:Tazobactam