Pharmacokinetics of oral fleroxacin in male and premenopausal female volunteers.
The pharmacokinetics of oral fleroxacin were compared in men and premenopausal women. The total volume of distribution of the drug was significantly smaller in women in the single-dose trial. No difference in other pharmacokinetic parameters was noted. Since adverse events appear to occur in women more commonly than in men, dose-response studies of fleroxacin in women may be appropriate.
Bertino
J S
JS
Department of Pharmacy Services, Bassett Healthcare, Cooperstown, New York 13326-1394, USA. jbertino@cscns.com
Nafziger
A N
AN
D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D005260:Female; D016576:Fleroxacin / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D012727:Sex Characteristics
D000890:Anti-Infective Agents; D016576:Fleroxacin