title: Acute renal failure with hyperuricemia as initial presentation of leukemia in children.
abstract: OBJECTIVE
  We report on two children who presented with hyperuricemia and acute renal failure (admission uric acid levels 57.4 and 59.2 mg/dl).
  
  
  RESULTS
  Both were subsequently diagnosed to have acute lymphoblastic leukemia, despite normal initial complete blood counts and peripheral smear. Neither patient had nephromegaly on renal ultrasound.
  
  
  CONCLUSIONS
  Hyperuricemia and acute renal failure, particularly if recurrent, may be an early presentation of childhood leukemia and should lead to a bone marrow aspirate/biopsy.
authors.affiliation: Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, USA.
authors.forename: G
authors.initials: G
authors.lastname: Larsen
authors.forename: M
authors.initials: M
authors.lastname: Loghman-Adham
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood* / Q000150:complications*; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid