Trisomy 18 in a canine thyroid adenoma.
A canine thyroid adenoma showing trisomy 18 as the sole clonal cytogenetic abnormality (9 of 30 analyzed metaphases) is reported. Because trisomies are a recurrent cytogenetic finding in human benign thyroid tumors as well, it is suggested that the molecular relationship between these trisomies and the development of thyroid tumors can be determined by comparative gene mapping.
Reimann
N
N
Center for Human Genetics and Genetic Counselling, University of Bremen, Germany.
Nolte
I
I
Bonk
U
U
Werner
M
M
Bullerdiek
J
J
Bartnitzke
S
S
D000236:Adenoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D004283:Dog Diseases; D004285:Dogs; D005260:Female; D006801:Humans; D007621:Karyotyping; D008677:Metaphase; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D014314:Trisomy; D014407:Tumor Cells, Cultured