title: Water flux from partial-thickness skin wounds: comparative study of the effects of Er:YAG and Ho:YAG lasers.
abstract: OBJECTIVE
  The clinical use of lasers to cut and coagulate tissue necessitates a better understanding of how the residual thermal damage affects healing. This study was designed to evaluate the effects of varying degrees of thermal damage on the healing process.
  
  
  METHODS
  Partial-thickness lesions were created in guinea pig skin using an Er:YAG laser, a Ho:YAG laser, and a scalpel. To monitor recovery of the stratum corneum, water flux from the wound sites was quantified and histological data obtained for approximately one week.
  
  
  RESULTS
  The data indicate an exponential water loss pattern from all wounds. Water flux from the scalpel- and the Er:YAG laser-induced wounds was initially high but decreased rapidly with decay rates (mean +/- SE) of 0.46 +/- 0.01 day-1 and 0.38 +/- 0.01 day-1, respectively. The Ho:YAG laser-induced wounds demonstrated a different pattern of decay with lower water flux values initially and a decay rate of only 0.13 +/- 0.01 day-1.
  
  
  CONCLUSIONS
  Histological and water flux data reveal that Er:YAG laser-induced wounds achieve epidermal integrity only slightly after scalpel-induced lesions, and Ho:YAG laser-induced wounds heal substantially slower and contain more granulation tissue.
authors.affiliation: Biomedical Engineering Department, Northwestern University, Evanston, Illinois 60208, USA.
authors.forename: B H
authors.initials: BH
authors.lastname: Jaffe
authors.forename: J T
authors.initials: JT
authors.lastname: Walsh
mesh_terms: D000538:Aluminum Silicates; D000818:Animals; D001834:Body Water / Q000378:metabolism; D062109:Dermatologic Surgical Procedures; D004817:Epidermis / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D004848:Epithelium / Q000473:pathology; D004871:Erbium; D005260:Female; D006097:Granulation Tissue / Q000473:pathology; D006168:Guinea Pigs; D006695:Holmium; D006965:Hyperplasia; D053685:Laser Therapy; D012867:Skin / Q000378:metabolism / Q000473:pathology; D013997:Time Factors; D014870:Water Loss, Insensible; D014945:Wound Healing; D015019:Yttrium
chemical_list: D000538:Aluminum Silicates; D015019:Yttrium; D004871:Erbium; D006695:Holmium