title: Lymphocyte subpopulations of regional lymph nodes in human colon and gastric adenocarcinomas.
abstract: In order to study the host immune response to tumours, previous knowledge of the cellular composition of regional draining lymph nodes is necessary. Enlarged regional lymph nodes are a common finding in colon and gastric adenocarcinomas. We have studied the cellular composition of normal non-reactive and of regional draining lymph nodes of colon and gastric adenocarcinomas. In normal non-reactive lymph nodes, T lymphocytes (CD2+, CD7+) constituted the largest fraction of the lymphoreticular cells. These lymphocytes were mainly CD4+, and there were more cells expressing the CD45RA isoform of the CD45 antigen than CD45RO. Reactive lymph nodes presented a decreased proportion of CD4+ CD45RA+ cells and an increased number of B cells. Although most of the T cells in the reactive nodes were CD4+ CD45RO+, their proportion was similar to that found in normal non-reactive nodes. We studied the presence of the molecules CD28 and CD80 involved in the processes of interaction and activation of T and B lymphocytes. The CD28 molecule was found in all the T lymphocytes, while the CD80 molecule was weakly expressed on the B lymphocyte membrane.
authors.affiliation: Unidad de Inmunologia, Hospital do Meixoeiro, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Lores-Vazquez
authors.forename: M
authors.initials: M
authors.lastname: Pacheco-Carracedo
authors.forename: J
authors.initials: J
authors.lastname: Oliver-Morales
authors.forename: P
authors.initials: P
authors.lastname: Parada-Gonzalez
authors.forename: F
authors.initials: F
authors.lastname: Gambón-Deza
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology*; D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D003110:Colonic Neoplasms / Q000276:immunology*; D006801:Humans; D017493:Leukocyte Common Antigens / Q000096:biosynthesis; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D016131:Lymphocyte Subsets / Q000276:immunology*; D008875:Middle Aged; D012016:Reference Values; D013274:Stomach Neoplasms / Q000276:immunology*
chemical_list: D017493:Leukocyte Common Antigens