Memory modulation by post-training glucose or insulin remains evident at long retention intervals.
Immediate posttraining intraperitoneal injection of alpha-D[+]-glucose (30 mg/kg) facilitated, whereas a nonconvulsive dose of insulin (8 IU/kg) impaired, 24-h retention, in male Swiss mice, of a one-trial step-through inhibitory avoidance task. When mice were trained and received immediate post-training glucose or insulin injections and were tested for retention either 1 week or 1 month later, at each retention interval performance was comparable to that found with a 24-h retention interval. Thus, memory modulation by post-training administration of either glucose or insulin remain evident at long retention intervals.
Kopf
S R
SR
Laboratorio de Neurofarmacologia de Procesos de Memoria, Universidad de Buenos Aires, Argentina.
Baratti
C M
CM
D000818:Animals; D005947:Glucose / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D051379:Mice; D012153:Retention, Psychology / Q000187:drug effects*; D012965:Sodium Chloride / Q000494:pharmacology
D007328:Insulin; D012965:Sodium Chloride; D005947:Glucose