title: Activity of nitric oxide-generating compounds against encephalomyocarditis virus.
abstract: Nitric oxide (NO) generated by two NO donors (sodium nitroprusside or S-nitroso-L-glutathione) was shown to exert a dose-dependent inhibition of encephalomyocarditis virus growth in L-929 cells. This activity was not due to the cytotoxic or direct virucidal effects of NO donors. L-929 cells were shown to produce NO endogenously, but this low level of production did not counter encephalomyocarditis virus replication.
authors.affiliation: Laboratoire de Virologie et Immunologie Expérimentales, Centre d'Etudes Pharmaceutiques de Châtenay-Malabry, France.
authors.forename: E
authors.initials: E
authors.lastname: Guillemard
authors.forename: M
authors.initials: M
authors.lastname: Geniteau-Legendre
authors.forename: R
authors.initials: R
authors.lastname: Kergot
authors.forename: G
authors.initials: G
authors.lastname: Lemaire
authors.forename: J F
authors.initials: JF
authors.lastname: Petit
authors.forename: C
authors.initials: C
authors.lastname: Labarre
authors.forename: A M
authors.initials: AM
authors.lastname: Quero
mesh_terms: D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D004686:Encephalomyocarditis virus / Q000187:drug effects*; D005978:Glutathione / Q000031:analogs & derivatives* / Q000494:pharmacology; D009569:Nitric Oxide / Q000378:metabolism; D009599:Nitroprusside / Q000494:pharmacology*; D009603:Nitroso Compounds / Q000494:pharmacology*; D026422:S-Nitrosoglutathione; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D009603:Nitroso Compounds; D009599:Nitroprusside; D009569:Nitric Oxide; D026422:S-Nitrosoglutathione; D005978:Glutathione