title: An index for assessing blindness in a multi-centre clinical trial: disulfiram for alcohol cessation--a VA cooperative study.
abstract: This paper considers an index to assess the success of blinding with application to a clinical trial of disulfiram. The index increases as the success of blinding increases, accounts for uncertain responses, and is scaled to an interval of 0.0 to 1.0, 0.0 being complete lack of blinding and 1.0 being complete blinding.
authors.affiliation: VA Medical Center, Oregon Health Sciences University, Portland 97201, USA.
authors.forename: K E
authors.initials: KE
authors.lastname: James
authors.forename: D A
authors.initials: DA
authors.lastname: Bloch
authors.forename: K K
authors.initials: KK
authors.lastname: Lee
authors.forename: H C
authors.initials: HC
authors.lastname: Kraemer
authors.forename: R K
authors.initials: RK
authors.lastname: Fuller
mesh_terms: D000427:Alcohol Deterrents / Q000627:therapeutic use; D000437:Alcoholism / Q000188:drug therapy; D015982:Bias; D004221:Disulfiram / Q000627:therapeutic use; D004311:Double-Blind Method; D006787:Hospitals, Veterans; D006801:Humans; D015337:Multicenter Studies as Topic / Q000592:standards*; D016032:Randomized Controlled Trials as Topic / Q000592:standards*; D015203:Reproducibility of Results; D012107:Research Design / Q000592:standards*
chemical_list: D000427:Alcohol Deterrents; D004221:Disulfiram