Effect of the peptide of thymic origin (synthetic thymohexine-RKNVYR) on hemopoietic cell progenitors in intact and irradiated animals.
Thymohexine treatment of intact CFU-S was shown not to change their capacity to form colonies both in vivo and in vitro. Thymohexine, similarly to thymus cells, increased colony yield from rabbit antimouse brain antiserum (RAMBS)-treated bone marrow. Combined treatment with thymohexine and thymocytes did not restore colony formation by RAMB serum-treated bone marrow. Thymohexine halved the harmful effect of low doses of ionizing radiation on CFU-S, and, moreover, treatment with the peptide after 4 Gy-irradiation led to more intensive restoration of CFU-S population as compared to control.
Semina
O V
OV
Medical Radiological Research Centre, Koroleva 4, Obninsk, Russia.
Semenets
T N
TN
Deigin
V I
VI
Korotkov
A M
AM
Poverenny
A M
AM
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009842:Oligopeptides / Q000494:pharmacology*; D010455:Peptides / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology*; D011828:Radiation Chimera; D013234:Stem Cells / Q000187:drug effects* / Q000528:radiation effects*; D013950:Thymus Gland / Q000737:chemistry*
D000276:Adjuvants, Immunologic; D009842:Oligopeptides; D010455:Peptides; C080035:thymohexin