title: High-resolution X-ray crystallography reveals precise binding interactions between human nonpancreatic secreted phospholipase A2 and a highly potent inhibitor (FPL67047XX).
authors.affiliation: Department of Life Science, Pohang University of Science and Technology, Kyungbuk, South Korea.
authors.forename: S S
authors.initials: SS
authors.lastname: Cha
authors.forename: D
authors.initials: D
authors.lastname: Lee
authors.forename: J
authors.initials: J
authors.lastname: Adams
authors.forename: J T
authors.initials: JT
authors.lastname: Kurdyla
authors.forename: C S
authors.initials: CS
authors.lastname: Jones
authors.forename: L A
authors.initials: LA
authors.lastname: Marshall
authors.forename: B
authors.initials: B
authors.lastname: Bolognese
authors.forename: S S
authors.initials: SS
authors.lastname: Abdel-Meguid
authors.forename: B H
authors.initials: BH
authors.lastname: Oh
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001559:Benzhydryl Compounds / Q000737:chemistry* / Q000378:metabolism* / Q000627:therapeutic use; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003460:Crystallization; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D006860:Hydrogen Bonding; D051379:Mice; D008958:Models, Molecular; D010031:Otitis / Q000188:drug therapy; D010741:Phospholipases A / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism*; D054467:Phospholipases A2; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001559:Benzhydryl Compounds; D004791:Enzyme Inhibitors; C086203:FPL 67047XX; D005680:gamma-Aminobutyric Acid; D010741:Phospholipases A; D054467:Phospholipases A2