Determining approximate estimates of inheritance parameters from sib-pair IBD proportions.
The use of IBD proportions from a large set of affected sib-pair data to estimate some or all of the main parameters describing the inheritance of a disease susceptibility gene is here considered. We assume there is no recombination present and neglect ascertainment bias, and assume that there are four distinct parental haplotypes present in each family.
Green
J R
JR
Jinnah College for Women, University of Peshawar, Pakistan.
Shah
S
S
D030342:Genetic Diseases, Inborn / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008957:Models, Genetic; D009679:Nuclear Family; D011336:Probability