[Molecular structures of eicosanoid receptors].
Prostanoids exert versatile actions in diverse tissues and cells through specific cell surface receptors. Molecular biological studies have revealed the primary structure of eight types and subtypes of prostanoid receptors from various species. They are coupled to different signal transduction systems and show different tissue distribution. In addition, multiple isoforms of prostaglandin E receptor EP3 subtype have been identified in various species. They are produced through alternative RNA splicing from a single gene and differ only in their carboxyl-terminal tails. These isoforms differ in the efficiency of G protein activation, in the specificity of coupling to G proteins or in sensitivity to desensitization. This molecular characterization is useful for understanding the diverse physiological role of prostanoids.
Negishi
M
M
Department of Physiological Chemistry, Kyoto University.
Ichikawa
A
A
D000595:Amino Acid Sequence; D000818:Animals; D051379:Mice; D008969:Molecular Sequence Data; D015394:Molecular Structure; D018055:Receptors, Eicosanoid / Q000737:chemistry*; D015398:Signal Transduction
D018055:Receptors, Eicosanoid