title: In utero congestive heart failure due to maternal indomethacin treatment for polyhydramnios and premature labour in a fetus with antenatal closure of the foramen ovale.
abstract: A case of severe fetal congestive heart failure due to occlusion of the ductus arteriosus in a mother treated with indomethacin for polyhydramnios and premature contractions is described. Closure of the fetal foramen ovale that escaped detection by prenatal echocardiography was later demonstrated at neonatal autopsy. This case suggests that indomethacin treatment in a ductus-dependent fetus may be hazardous. Therefore, careful surveillance of the fetus exposed to indomethacin in utero is warranted.
authors.affiliation: Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Achiron
authors.forename: S
authors.initials: S
authors.lastname: Lipitz
authors.forename: D
authors.initials: D
authors.lastname: Kidron
authors.forename: M
authors.initials: M
authors.lastname: Berant
authors.forename: J
authors.initials: J
authors.lastname: Hegesh
authors.forename: Z
authors.initials: Z
authors.lastname: Rotstein
mesh_terms: D000328:Adult; D001344:Autopsy; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D006333:Heart Failure / Q000139:chemically induced* / Q000151:congenital / Q000000981:diagnostic imaging; D006346:Heart Septum / Q000473:pathology; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects* / Q000627:therapeutic use; D007752:Obstetric Labor, Premature / Q000188:drug therapy*; D010210:Papillary Muscles / Q000648:ultrastructure; D006831:Polyhydramnios / Q000188:drug therapy*; D011247:Pregnancy; D015149:Tocolytic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016216:Ultrasonography, Prenatal
chemical_list: D015149:Tocolytic Agents; D007213:Indomethacin