[A 13-week toxicity study of simultaneous administration of cochineal and aluminum potassium sulfate in rats].
Cochineal (C), a scarlet material extracted from the powdered pregnant insect, Dactylopius Coceus Costa, is used as a color food additive in the form of aluminum lakes. A 13 week subchronic toxicity study was conducted to investigate the effects of simultaneous administration of C and aluminum potassium sulfate (A). Male and female Wistar rats (5-weeks-old, 15 rats/group) were given diets containing 0.75%A and 0.75%C (1.5%AC), 1.5%A and 1.5%C (3%AC), 3%C alone or 3%A alone. The following results were obtained. 1) No toxic symptoms or death occurred in any treated group. Body weight gain in male rats of the 3%A group decreased significantly. 2) Serum levels of phospholipids, triglycerides (TG) and total cholesterol in male rats and TG in female rats fed 3%C, 3%A or 3%AC were significantly decreased at the 13th week. The serum level of glutamate dehydrogenase (GIDH) in male rats treated with 1.5% or 3%AC was increased at the 4th week but no difference from control was observed at the 13th week. 3) No histopathological changes attributable to A and/or C administration were observed. In this 13-week oral toxicity study, no dose-dependent synergistic effects of simultaneous administration of C and A were found except for an increase in serum GIDH.
Kawasaki
Y
Y
Umemura
T
T
Sai
K
K
Hasegawa
R
R
Momma
J
J
Saitoh
M
M
Matsushima
Y
Y
Nakaji
Y
Y
Tsuda
M
M
Kurokawa
Y
Y
D000284:Administration, Oral; D000534:Alum Compounds / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002329:Carmine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D004338:Drug Combinations; D005260:Female; D005505:Food Coloring Agents / Q000008:administration & dosage / Q000633:toxicity*; D005969:Glutamate Dehydrogenase / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000534:Alum Compounds; D004338:Drug Combinations; D005505:Food Coloring Agents; D008055:Lipids; C041524:aluminum sulfate; D002329:Carmine; D005969:Glutamate Dehydrogenase