Langerhans cell histiocytosis, diabetes insipidus, hyperprolactinemia and empty sella: a four-fold association. Report of two cases.
Two cases of Langerhans cell histiocytosis (LCH) expressing as Hand-Schuller-Christian syndrome with diabetes insipidus, hyperprolactinemia and empty sella are here reported. Up-to-date this four-fold association is lacking in world literature and it is here discussed in the light if LCH is a cancer or the clinical expression of an immunologic disorder.
Panza
N
N
Settore di Immunologia ed Endocrinologia Oncologica, Ospedale A. Cardarelli, Napoli, Italy.
Merola
B
B
Colao
A
A
Iodice
G
G
de Bellis
A
A
Bizzarro
A
A
Bellastella
A
A
Lombardi
G
G
D000328:Adult; D003919:Diabetes Insipidus / Q000097:blood / Q000503:physiopathology*; D004652:Empty Sella Syndrome / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000097:blood / Q000503:physiopathology*; D006728:Hormones / Q000097:blood; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged
D006728:Hormones