title: Detection of hepatocellular carcinoma by intraarterially enhanced ultrasonography with CO2 microbubbles. Comparison with DSA, dynamic CT, and Lipiodol CT.
abstract: OBJECTIVE
  To evaluate the diagnostic value of contrast-enhanced US with CO2 microbubbles (EU) for HCCs. Detectability was compared with DSA, dynamic CT, and Lipiodol CT.
  
  
  METHODS
  Forty-seven histologically proven HCCs detected with US were evaluated with EU, DSA, and dynamic CT. In 23 patients (35 lesions), Lipiodol CT was also performed. The size of the tumors ranged from 8 to 71 mm (average 28.1 mm); 24 lesions were smaller than 20 mm and 23 lesions were larger than 20 mm.
  
  
  RESULTS
  Overall detection was possible in 40 of 47 lesions (85%) by EU, in 32 of 47 (68%) by DSA, in 33 of 47 (74%) by dynamic CT, and in 27 of 35 (77%) by Lipiodol CT. In tumors smaller than 20 mm, detection was possible in 21 of 24 lesions (88%) by EU, 14 of 24 (58%) by DSA, 14 of 24 (58%) by dynamic CT, and 11 of 17 (65%) by Lipiodol CT.
  
  
  CONCLUSIONS
  EU has significant diagnostic value for detection of HCCs, particularly tumors smaller than 20 mm.
authors.affiliation: Department of Radiology, Kumamoto University Hospital, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Arakawa
authors.forename: T
authors.initials: T
authors.lastname: Nishiharu
authors.forename: T
authors.initials: T
authors.lastname: Matsukawa
authors.forename: J
authors.initials: J
authors.lastname: Urata
authors.forename: Y
authors.initials: Y
authors.lastname: Hatanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Yamashita
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Kanemitsu
authors.forename: M
authors.initials: M
authors.lastname: Mihara
mesh_terms: D015901:Angiography, Digital Subtraction; D002245:Carbon Dioxide; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000628:therapy; D016461:Chemoembolization, Therapeutic; D003287:Contrast Media; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007459:Iodized Oil / Q000008:administration & dosage; D007472:Iohexol; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography / Q000379:methods
chemical_list: D003287:Contrast Media; D002245:Carbon Dioxide; D007472:Iohexol; D007459:Iodized Oil