Leukocytes in capillary flow.
During disease, the flow of blood cells through the capillary network is one of the most perilous events in the microcirculation. Capillary distensibility, cytoplasmic activity of endothelial cells, red cells and leukocytes play an important role in capillary perfusion. Occlusion of capillaries is one of the early signs of vascular failure and is encountered in many different conditions and organs. Adhesion of leukocytes to the endothelium via expression of membrane adhesion molecules leads to microvascular entrapment with capillary occlusion.
Schmid-Schönbein
G W
GW
Department of Bioengineering, University of California, San Diego, La Jolla 92093-0412, USA.
Lee
J
J
D000818:Animals; D001783:Blood Flow Velocity; D002196:Capillaries / Q000502:physiology* / Q000648:ultrastructure; D002448:Cell Adhesion; D002449:Cell Aggregation; D004730:Endothelium, Vascular / Q000502:physiology; D007962:Leukocytes / Q000502:physiology*; D008833:Microcirculation; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009504:Neutrophils / Q000648:ultrastructure; D051381:Rats; D012039:Regional Blood Flow