title: A tubular pediatric ventricular assist device. Design considerations and system characteristics.
abstract: A clinical need exists for the short-term use of pediatric ventricular assist device in children and small infants who are critically ill with heart failure unresponsive to pharmacologic support or, in the case of irreversible heart failure, as a bridge to a transplant device. The design considerations and device characteristics of a tubular pump are presented. The device consists of an integrally formed inflow valve, pump chamber, and outflow valve in a tubular construction. This design approach was selected due to its simplicity of fabrication, which can result in a reliable and low cost device. The inflow valve and pump are actuated pneumatically through a single drive line. The outflow valve can be either actively actuated or operated passively. A 5 ml stroke volume device was built and characterized in vitro and in vivo. This pump can generate 0.5 L/min at 100 beats per minute. Larger stroke volume devices can be and have been fabricated using the same principle.
authors.affiliation: ABIOMED R&D, Inc., Danvers, Massachusetts 01923, USA.
authors.forename: R T
authors.initials: RT
authors.lastname: Kung
authors.forename: G L
authors.initials: GL
authors.lastname: Champsaur
mesh_terms: D000465:Algorithms; D000818:Animals; D001696:Biomechanical Phenomena; D001794:Blood Pressure / Q000502:physiology; D004195:Disease Models, Animal; D004867:Equipment Design; D006323:Heart Arrest / Q000628:therapy; D006339:Heart Rate / Q000502:physiology; D006353:Heart-Assist Devices; D006454:Hemoglobins / Q000032:analysis / Q000378:metabolism; D015203:Reproducibility of Results; D012756:Sheep; D013318:Stroke Volume / Q000502:physiology
chemical_list: D006454:Hemoglobins