Gene targeting in kidney development.
Cancer and development are conceptually related because tumor formation in many cases results from the aberrant expression of a developmental program. This is certainly true of Wilms' tumors, which display a range of phenotypes resembling various stages of kidney development. WT1 has been identified as a tumor suppressor gene involved in a subset of Wilms' tumors. Gene targeting of the WT1 gene demonstrated the requirement for this gene product during early urogenital development. Several other genes, including Wnt-4, c-ret, ld and lim 1, have been shown by gene targeting to also be involved in early kidney development. This review discusses gene targeting as an approach to the study of development and reviews the phenotypes of these and other genes involved in kidney organogenesis.
Kreidberg
J A
JA
Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics; D029721:Drosophila Proteins; D005786:Gene Expression Regulation; D015972:Gene Expression Regulation, Neoplastic; D018390:Gene Targeting; D016162:Genes, Wilms Tumor / Q000235:genetics; D018398:Homeodomain Proteins / Q000235:genetics; D007668:Kidney / Q000196:embryology*; D007680:Kidney Neoplasms / Q000235:genetics*; D060850:LIM-Homeodomain Proteins; D051379:Mice; D008817:Mice, Mutant Strains; D008822:Mice, Transgenic; D009857:Oncogenes / Q000235:genetics; D010641:Phenotype; D011518:Proto-Oncogene Proteins / Q000235:genetics; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics; D014566:Urogenital System / Q000196:embryology; D025721:WT1 Proteins; D009396:Wilms Tumor / Q000235:genetics; D051153:Wnt Proteins; D060528:Wnt4 Protein
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D060850:LIM-Homeodomain Proteins; C499523:Lhx1 protein, mouse; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors; D025721:WT1 Proteins; D051153:Wnt Proteins; D060528:Wnt4 Protein; C555582:Wnt4 protein, mouse; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases; C416649:Ret protein, Drosophila; C494999:Ret protein, mouse