title: Cyanoacrylate adhesive with conjunctival resection and superficial keratectomy in Mooren's ulcer.
abstract: Seventeen eyes of thirteen patients with Mooren's ulcer were treated with a combination therapy of local and systemic steroids, conjunctival resection, superficial keratectomy and application of cyanoacrylate tissue adhesive. The pathology was classified as acute, subacute and chronic. Ulcers were graded based on the extent of corneal thinning, degree and extent of ulceration, and amount of inflammation. Fourteen eyes (82.4%) healed completely with formation of a vascularised scars, while three eyes (17.6%) failed to respond to treatment and either went into phthisis bulbi or healed with gross tissue distortion. Our study suggests an early intervention of this therapy with cyanoacrylate tissue adhesive application for effective control of Mooren's ulceration.
authors.affiliation: Sight Savers Cornea Training Centre, L. V. Prasad Eye Institute, Hyderabad.
authors.forename: V
authors.initials: V
authors.lastname: Agrawal
authors.forename: A
authors.initials: A
authors.lastname: Kumar
authors.forename: V
authors.initials: V
authors.lastname: Sangwan
authors.forename: G N
authors.initials: GN
authors.lastname: Rao
mesh_terms: D000208:Acute Disease; D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001623:Betamethasone / Q000627:therapeutic use; D002908:Chronic Disease; D003228:Conjunctiva / Q000187:drug effects / Q000601:surgery*; D016039:Corneal Transplantation / Q000379:methods*; D003320:Corneal Ulcer / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D003487:Cyanoacrylates / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014792:Visual Acuity
chemical_list: D000893:Anti-Inflammatory Agents; D003487:Cyanoacrylates; D005938:Glucocorticoids; D001623:Betamethasone