Changes in polyurethane calcification due to antibiotics.
To develop artificial materials for prolonged use in the vascular system, the complicated process of surface-induced calcification must be better understood. Calcification was examined on porous polyurethane incubated in metastable solutions of calcium phosphate, and the role of certain antibiotics in the medium was evaluated. It seems that certain aminoglycoside antibiotics can modify polyurethane surfaces and, subsequently, their mineralization process. In addition, these antibiotics may alter the calcium transport through polyurethanes. Therefore, it is conceivable that certain antibiotics can, in addition to producing their antibacterial effect, modulate surface calcium binding by changing the calcium mobilization and crystallization. Additional studies are needed to develop applications.
Chandy
T
T
Division of Biosurface Technology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojappura, Trivandrum, India.
Vasudev
S C
SC
Sharma
C P
CP
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D001665:Binding Sites; D001672:Biocompatible Materials; D002114:Calcinosis / Q000517:prevention & control*; D002130:Calcium Phosphates / Q000378:metabolism; D002417:Cattle; D003460:Crystallization; D066298:In Vitro Techniques; D008567:Membranes, Artificial; D008855:Microscopy, Electron, Scanning; D011140:Polyurethanes / Q000737:chemistry* / Q000378:metabolism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D002130:Calcium Phosphates; D008567:Membranes, Artificial; D011140:Polyurethanes; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C044690:polyetherurethane urea; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous