[Membranotropic effect of a new derivative of N-3 polyunsaturated fatty acids during experimental stress].
A new derivative of n-3 polyunsaturated fatty acids (PUFA) has been studied for its effect on membrane lipid composition and peroxidation under long-term pretreatment in Wistar male rats under experimental stress. The purpose of the study was to determine membrane mechanisms of the stress-protective effect of this preparation found in our previous investigations. A significant increase of lipid peroxidation and suppression of the main enzymes of free-radical protective system (catalase, superoxide dismutase) were observed in erythrocyte membranes of rats after the long-term stress. Phospholipid and cholesterol composition of membranes was also altered. Cholesterol/phospholipid ratio and lysophosphatide content in erythrocyte membranes were increased. These changes were less pronounced in the pretreated group. Some indices even did not differ from those in the non-stressed group. These results indicate that the long-term pretreatment with n-3 PUFA in rats partially protects membrane lipid composition, stress-induced alterations and prevents suppression of membrane-bound enzymes.
Tishchenko
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Kresiun
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D000818:Animals; D002374:Catalase / Q000097:blood / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004910:Erythrocyte Membrane / Q000187:drug effects*; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D005609:Free Radicals; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008563:Membrane Lipids / Q000097:blood*; D010743:Phospholipids / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000097:blood / Q000188:drug therapy*; D013482:Superoxide Dismutase / Q000097:blood / Q000187:drug effects
D015525:Fatty Acids, Omega-3; D005609:Free Radicals; D008563:Membrane Lipids; D010743:Phospholipids; D002784:Cholesterol; D002374:Catalase; D013482:Superoxide Dismutase