title: [Effect of resorption of Purisole (mannitol/sorbitol solution) as a distention medium in hysteroscopic operations on cardiovascular and laboratory parameters and energy metabolism--a prospective non-randomized observational study].
abstract: This paper reports on an open explorative study on the absorption of the electrolytfree distension medium Purisole (Mannitol-Sorbitol solution) during hysteroscopic procedures and its effects on laboratory and cardiovascular parameters. Intra- and postoperative levels of mannitol and sorbitol in urine were also measured to determine elimination of both components. The study population consisted of 84 patients aged 22-62 years. 54 women underwent ablative (resection of submucous fibroids, endometrial ablation, septum resection), 30 patients non-ablative operative hysteroscopic procedures (synechiolysis, hysteroscopic proximal tubal catheterisation). The duration of operations was between 23-48 minutes. Ethanol was added to the Purisole solution for determination of resorption. In 57 cases 1% ethanol in Purisole was used as irrigating fluid. In 27 cases 2% ethanol was added to the distension fluid. A median slight encrease of central venous pressure was noted during the procedures. 18 women had an intraoperative hyponatriaemia (only 4 patients < 130 mmmol/1). For the 15 patients, in which ethanol absorption was noted, fluid resorption was calculated on the basis of blood alcohol concentration (median 850 ml). Resorption was below the determination threshold in the other 69 women. Urine examination showed intra- and postoperatively increased concentrations of sorbitol and mannitol. Fluid overload and intraoperative cardiovascular complications did not occur in our patients.
authors.affiliation: Universitäts-Frauenklinik Heidelberg.
authors.forename: B
authors.initials: B
authors.lastname: Aydeniz
authors.forename: D
authors.initials: D
authors.lastname: Wallwiener
authors.forename: S
authors.initials: S
authors.lastname: Rimbach
authors.forename: A
authors.initials: A
authors.lastname: Fischer
authors.forename: R
authors.initials: R
authors.lastname: Conradi
authors.forename: J
authors.initials: J
authors.lastname: Weimann
authors.forename: G
authors.initials: G
authors.lastname: Bastert
mesh_terms: D000328:Adult; D004724:Endoscopy; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D015907:Hysteroscopy; D008353:Mannitol / Q000009:adverse effects* / Q000493:pharmacokinetics; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011446:Prospective Studies; D013012:Sorbitol / Q000009:adverse effects* / Q000493:pharmacokinetics; D007507:Therapeutic Irrigation; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D008353:Mannitol; D013012:Sorbitol