title: An inhibitor of S-hemolysin, SHI, produced by streptomyces sp. strain No. 6288.
abstract: Streptomyces sp. strain No. 6288 produces S-Hemolysin, which is a unique phospholipase C with a high substrate specificity for sphingomyelin. Moreover, the strain also produced two kinds of phospholipase inhibitors, designated as SHI and S-PLI, in different phases of cultivation. The purified SHI was shown to be a basic substance containing an amino group and glycoside moiety, and it was a more effective inhibitor of S-Hemolysin and sphingomyelinase from Streptomyces sp. with a higher substrate specificity for sphingomyelin than alpha-toxin from Clostridium perfringens.
authors.affiliation: Laboratory of Medicinal Microbiology, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Siddique
authors.forename: M
authors.initials: M
authors.lastname: Uyeda
mesh_terms: D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006027:Glycosides / Q000096:biosynthesis / Q000494:pharmacology*; D006460:Hemolysin Proteins; D013302:Streptomyces / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D004791:Enzyme Inhibitors; D006027:Glycosides; D006460:Hemolysin Proteins