title: A locus on the X chromosome is linked to body length in mice.
abstract: Linkage between body length (anus to nose (AN) length) and three markers on the mouse X Chromosome was found in an interspecific backcross ((C57BL/6J x Mus spretus) F 1x C57BL/6J), designated BSB. A cross of 409 mice were scored for 148 genetic markers distributed on all chromosomes except the Y Chromosome. Statistical analysis revealed highly significant linkage (LOD score 5.5) between body length and a locus in the middle portion of the X Chromosome, the nearest markers being the microsatellite marker DXMit73 and a farnesyl pyrophosphate locus (Fpsl9) 3.1 cM proximal to DXMit73. The locus explains 10% of the variance in AN length and affects both males and females to about the same extent.
authors.affiliation: Department of Medicine, University of California, Los Angeles, USA.
authors.forename: A V
authors.initials: AV
authors.lastname: Lembertas
authors.forename: J S
authors.initials: JS
authors.lastname: Fisher
authors.forename: C H
authors.initials: CH
authors.lastname: Warden
authors.forename: P Z
authors.initials: PZ
authors.lastname: Wen
authors.forename: Y R
authors.initials: YR
authors.lastname: Xia
authors.forename: A J
authors.initials: AJ
authors.lastname: Lusis
mesh_terms: D000818:Animals; D001699:Biometry; D001835:Body Weight; D003433:Crosses, Genetic; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000033:anatomy & histology*; D009115:Muridae; D010641:Phenotype; D014960:X Chromosome / Q000235:genetics*
chemical_list: D005819:Genetic Markers