The impact of D-Trp6 LH-RH on plasma lipid levels.
BACKGROUND
There is increasing evidence regarding the correlation between the risk of death from cardiovascular disease and low levels of HDL-cholesterol or high plasma concentrations of LDL-cholesterol, total cholesterol, and triglycerides. Gonadotropin releasing hormone (GhRH) analogues are widely used in assisted reproduction programs. Therefore, it seems important to evaluate possible changes in serum lipoprotein levels following treatment with these compounds.


OBJECTIVE
Our purpose was to assess possible lipoprotein changes following administration of the long-acting GnRH analogue, D-Trp6 luteinizing hormone-releasing hormone (LH-RH).


METHODS
Serum levels of cholesterol, HDL-cholesterol, LDL-cholesterol, and triglicerydes were determined before and after 6 weeks of treatment.


RESULTS
No significant changes in either cholesterol or HDL-cholesterol, LDL-cholesterol, or triglicerydes following treatment with D-Trp6 LH-RH were demonstrated in the group of 25 patients investigated.


CONCLUSIONS
Short-term use of D-Trp6 LH-RH is not associated with any significant change in plasma lipid levels. Further studies are still required with patients undergoing repeated treatment cycles, especially those who exhibit elevated pretreatment plasma lipid levels, to confirm the long-term safety of GnRH analogues with respect to lipid metabolism.
Goldman
G A
GA
Department of Obstetrics and Gynecology, Beilinson Medical Center, Petah-Tikva, Israel.
Schoenfeld
A
A
Ovadia
J
J
Fisch
B
B
D001161:Arteriosclerosis / Q000378:metabolism; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D003327:Coronary Disease / Q000378:metabolism / Q000503:physiopathology; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000494:pharmacology; D006801:Humans; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000097:blood / Q000378:metabolism; D008186:Luteolytic Agents / Q000494:pharmacology; D008596:Menotropins / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood / Q000378:metabolism; D017329:Triptorelin Pamoate / Q000494:pharmacology*
D008055:Lipids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008186:Luteolytic Agents; D014280:Triglycerides; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; D008596:Menotropins; D002784:Cholesterol