title: Histopathology and immunofluorescence of discoid lupus erythematosus in children.
abstract: The histopathology and immunofluorescence of discoid lupus erythematosus (DLE) are well documented in adults, but in children they have not been studied systematically. We reviewed nine skin biopsy specimens from six children with DLE. Only three specimens showed the well-developed epidermal changes seen in lesions of adults with DLE, and in the other six, these changes were either mild or absent. All nine specimens showed some degree of vacuolar alteration of the basal layer, ranging from focal and mild to severe. They all had a moderate to heavy lymphocytic dermal infiltrate in a perivascular and periadnexal distribution. Direct immunofluorescence performed on five specimens of lesional skin was weakly positive for IgM or IgG in three cases, negative in one, and strongly positive for IgM, IgG, IgA, and C3 in one. This study indicates that the range of histologic and immunofluorescence features in children with DLE is similar to that in adults. The histologic findings are distinctive enough to be useful in establishing the diagnosis, although clinicopathologic correlation is required.
authors.affiliation: Department of Dermatology, University of Minnesota, Minneapolis, USA.
authors.forename: P M
authors.initials: PM
authors.lastname: George
authors.forename: A F
authors.initials: AF
authors.lastname: Hood
authors.forename: E B
authors.initials: EB
authors.lastname: Rest
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000473:pathology; D001485:Basement Membrane / Q000473:pathology; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003176:Complement C3 / Q000032:analysis; D004817:Epidermis / Q000473:pathology; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008179:Lupus Erythematosus, Discoid / Q000473:pathology*; D008297:Male; D012867:Skin / Q000098:blood supply / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology; D014617:Vacuoles / Q000648:ultrastructure
chemical_list: D003176:Complement C3; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M