Effects of apolipoprotein E genotype on cortical neuropathology in senile dementia of the Lewy body and Alzheimer's disease.
Apolipoprotein E (APO E) genotypes were determined in a UK population of neuropathologically confirmed control cases, and in cases of Lewy body dementia (SDLT) and late onset Alzheimer's disease (AD). APO E epsilon 4 allele frequency was significantly elevated in both SDLT and AD groups with a concomitant reduction in the APO E epsilon 3 allele frequency. The epsilon 2 allele frequency in the AD group was only 25% of the control population, though because of the relatively small sample size this reduction was not significant; the epsilon 2 allele frequency in the SDLT group was normal. No significant association was found between senile plaque density and neurofibrillary tangle density in the neocortex and APO E allele dose in either SDLT or AD. Although the possession of APO E epsilon 4 is associated with an increased risk of developing SDLT and AD, actual APO E genotype does not appear to affect the burden of pathology.
Benjamin
R
R
MRC Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle upon Tyne.
Leake
A
A
Ince
P G
PG
Perry
R H
RH
McKeith
I G
IG
Edwardson
J A
JA
Morris
C M
CM
D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics / Q000473:pathology*; D001057:Apolipoproteins E / Q000235:genetics*; D001483:Base Sequence; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000473:pathology*; D003704:Dementia / Q000235:genetics / Q000473:pathology*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008969:Molecular Sequence Data; D010300:Parkinson Disease / Q000235:genetics / Q000473:pathology*
D001057:Apolipoproteins E