Preparation of pentofuranoside derivatives having ethynylene group and their reactions with oligodeoxyribonucleotides.
Furanoside derivatives having ethynylene group and related compounds were prepared. The reaction of these functionalized furanosides with oligodeoxy-ribonucleotide (21 mer, 5'-32P-GATAAGCTTGAAT TCATGGCC-3') and subsequent treatment with piperidine resulted in cleavage of the oligonucleotide.
Sakagami
K
K
Department of Chemisty, College of Science and Engineering, Aoyama Gakuin University, Tokyo, Japan.
Yamaga
H
H
Ogawa
A
A
Michida
M
M
Mitsunobu
O
O
D001483:Base Sequence; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D015394:Molecular Structure; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D010429:Pentoses / Q000138:chemical synthesis* / Q000737:chemistry; D010880:Piperidines
D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D010429:Pentoses; D010880:Piperidines; C032727:piperidine