Differences in some behavioural effects of deprenyl and amphetamine enantiomers in rats.
Effects of deprenyl and amphetamine enantiomers on different behavioural patterns were compared. Whereas (+)-amphetamine in doses of 1-3 mg/kg SC, (-)-amphetamine, and (+)-deprenyl in doses of 5-20 mg/kg SC increased the locomotor activity and the time the animals displayed stereotyped head movement, enhanced the acquisition of conditioned avoidance responses, and developed positive place preference conditioning, (-)-deprenyl, even in as high a dose as 20 mg/kg SC, failed to show any amphetamine-type behavioural effect. The results provide further proof why (-)-deprenyl, in contrast to other members of the amphetamine family, can be considered as a safe drug.
Timár
J
J
Department of Pharmacology, Semmelweis University of Medicine, Budapest, Hungary.
Gyarmati
Z
Z
Barna
L
L
Knoll
B
B
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects; D005260:Female; D019416:Head Movements / Q000187:drug effects; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012642:Selegiline / Q000494:pharmacology*; D013237:Stereoisomerism; D013239:Stereotyped Behavior / Q000187:drug effects
D000697:Central Nervous System Stimulants; D008996:Monoamine Oxidase Inhibitors; D012642:Selegiline; D000661:Amphetamine