Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor.
Huffman
J W
JW
Department of Chemistry, Clemson University, South Carolina 29634-1905, USA.
Yu
S
S
Showalter
V
V
Abood
M E
ME
Wiley
J L
JL
Compton
D R
DR
Martin
B R
BR
Bramblett
R D
RD
Reggio
P H
PH
D000818:Animals; D002186:Cannabinoids / Q000737:chemistry; D002462:Cell Membrane / Q000378:metabolism; D004192:Discrimination, Psychological / Q000187:drug effects; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D006801:Humans; D015394:Molecular Structure; D010636:Phenols; D051381:Rats; D043885:Receptor, Cannabinoid, CB2; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000378:metabolism*; D013329:Structure-Activity Relationship
D002186:Cannabinoids; C469526:Cnr2 protein, rat; D010636:Phenols; D043885:Receptor, Cannabinoid, CB2; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug; C101717:1',2'-dimethylheptyl-1-deoxy-delta(8)-tetrahydrocannabinol; D013759:Dronabinol