[Glutathione reductase activation in acute alcoholic intoxication].
Experiments carried out on rats were aimed to study the effect of acute alcohol intoxication on activity of cytoplasmic and mitochondrial forms of glutathione reductase. It has been found that alcohol activates the enzyme. The in vitro experiments have confirmed the effect. The correlation between the activity of the studied enzyme and the content of various forms of endogenous flavines is observed. It is stated that an increase in the alcohol dehydrogenase activity in tissues of rats under study induces a drastic rise of the number of restored nicotinamide coenzymes and as a result of this the glutathione reductase activity grows.
Sokolovs'ka
V V
VV
Petrov
S A
SA
D000426:Alcohol Dehydrogenase / Q000378:metabolism; D000435:Alcoholic Intoxication / Q000201:enzymology*; D000818:Animals; D004789:Enzyme Activation; D005182:Flavin-Adenine Dinucleotide / Q000378:metabolism; D005415:Flavins / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005980:Glutathione Reductase / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013056:Spectrophotometry, Ultraviolet
D005415:Flavins; D005182:Flavin-Adenine Dinucleotide; D000426:Alcohol Dehydrogenase; D005980:Glutathione Reductase; D005978:Glutathione