Efficacy of quinolones in preventing Staphylococcus aureus-induced abscess in mice.
The new fluoroquinolones clinafloxacin, CI-990 (PD 131112/PD 131628), sparfloxacin, and PD 138312 were bactericidal against Staphylococcus aureus with MICs > or = 4-fold lower than ciprofloxacin values. In a murine subcutaneous abscess model (subcutaneous/oral dosing) the new drugs displayed protective activities against five strains which were generally higher (up to 19-fold) than ciprofloxacin values.
Cohen
M A
MA
Infectious Diseases Section, Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan 48105-2495, USA.
Gage
J W
JW
Huband
M D
MD
Meservey
M A
MA
VanderRoest
S R
SR
Yoder
S L
SL
D000038:Abscess / Q000517:prevention & control*; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D024841:Fluoroquinolones; D051379:Mice; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000517:prevention & control*; D013211:Staphylococcus aureus / Q000187:drug effects
D000890:Anti-Infective Agents; D024841:Fluoroquinolones