[The effect of STK-1 receptor (FLK2/FLT3) ligand on human erythropoiesis in vitro. Clinical implications].
The influence of a new discovered haematopoietic growth factor known as ligand of STK-1 receptor (FLK2/FLT3) on growth of human erytropoietic progenitors in vitro was evaluated. Studies were performed on bone marrow cells enriched in haematopoietic progenitors expressing CD 34 antigen in serum supplemented as in serum free medium. In conclusion STK-1 receptor ligand (STK-1L) does not influence the growth of human erythroid progenitors in vitro. Therefore STK-1L would not find practical application in future in vivo therapy as erythropoiesis stimulatory agent.
Ratajczak
J
J
Z Zakładu Patologii Komórki PAM w Szczecinie.
Marlicz
W
W
Ratajczak
M Z
MZ
D002478:Cells, Cultured; D015672:Erythroid Precursor Cells / Q000166:cytology / Q000187:drug effects*; D004920:Erythropoiesis / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008024:Ligands; D020794:Receptor Protein-Tyrosine Kinases / Q000494:pharmacology* / Q000502:physiology; D011994:Recombinant Proteins
D008024:Ligands; D011994:Recombinant Proteins; D020794:Receptor Protein-Tyrosine Kinases