title: Correlation between the antibody response to influenza vaccine and helper T cell subsets in healthy aging.
abstract: To investigate the effects of the altered composition of the helper T cell compartment in ageing on the humoral response to influenza vaccine, we investigated correlations between helper T cell subsets and anti-influenza antibody responses in 23 JUNIEUR healthy young and 41 SENIEUR healthy elderly subjects. Naive helper T cell numbers (CD4+ CD45RA+) were negatively correlated with antibody production to two of the four strains investigated in JUNIEURS only. By contrast, memory helper T cell numbers (CD4+CD45ROhi) were positively correlated with in vivo IgG antibody titres to three of the four vaccine strains. Age-related differences in the composition of the helper T cell compartment, however, did not explain the lower IgG antibody response that was observed to two of the four vaccine strains examined.
authors.affiliation: Department of Pathology, University of Leiden, Netherlands.
authors.forename: E J
authors.initials: EJ
authors.lastname: Remarque
authors.forename: E W
authors.initials: EW
authors.lastname: Nijhuis
authors.forename: B
authors.initials: B
authors.lastname: Hinloopen
authors.forename: L
authors.initials: L
authors.lastname: Nagelkerken
authors.forename: E A
authors.initials: EA
authors.lastname: van der Velde
authors.forename: G J
authors.initials: GJ
authors.lastname: Ligthart
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology*; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000917:Antibody Formation / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000096:biosynthesis* / Q000097:blood; D007252:Influenza Vaccines / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D008875:Middle Aged; D012044:Regression Analysis; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D007132:Immunoglobulin Isotypes; D007252:Influenza Vaccines