Analysis of the sialic acid-binding activity of the transmissible gastroenteritis virus.
Porcine transmissible gastroenteritis virus (TGEV) has been shown to agglutinate erythrocytes using alpha 2,3-linked sialic acid on the cell surface as binding site. The hemagglutinating activity requires the pretreatment of virus with neuraminidase. We obtained evidence that TGEV recognizes not only N-acetylneuraminic acid but also N-glycoloylneuraminic acid, a sialic acid present on many porcine cells.
Schultze
B
B
Institut für Virologie, Philipps-Universität Marburg, Germany.
Enjuanes
L
L
Herrler
G
G
D000818:Animals; D001665:Binding Sites; D002417:Cattle; D002460:Cell Line; D002645:Chickens; D004912:Erythrocytes / Q000276:immunology; D006384:Hemagglutination / Q000187:drug effects; D015394:Molecular Structure; D019158:N-Acetylneuraminic Acid; D009438:Neuraminic Acids / Q000097:blood / Q000737:chemistry; D009439:Neuraminidase / Q000494:pharmacology; D012794:Sialic Acids / Q000097:blood* / Q000737:chemistry; D013552:Swine; D005760:Transmissible gastroenteritis virus / Q000276:immunology / Q000502:physiology*
D009438:Neuraminic Acids; D012794:Sialic Acids; C032592:N-glycolylneuraminic acid; D009439:Neuraminidase; D019158:N-Acetylneuraminic Acid