title: Synthesis of oligonucleotides containing a carbocyclic nucleoside.
abstract: 2'-Bromo-substituted cyclopentane-type carbocyclic nucleoside (7a, 7b) was synthesized from sodium cyclopentadienylide. Subsequently, 7a was incorporated into DNA oligomer by means of a conventional phosphoramidite method. Melting-temperature, CD spectra and chemical reaction of such carbocyclic oligonucleotide are described.
authors.affiliation: Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Komeda
authors.forename: K
authors.initials: K
authors.lastname: Sakata
authors.forename: H
authors.initials: H
authors.lastname: Sugiyama
authors.forename: I
authors.initials: I
authors.lastname: Saito
mesh_terms: D001483:Base Sequence; D003517:Cyclopentanes / Q000737:chemistry; D008722:Methods; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D003517:Cyclopentanes; D009705:Nucleosides; D009841:Oligonucleotides