title: Urinary trypsinogen activation peptides (TAP) are not increased in mild ERCP-induced pancreatitis.
abstract: Acute pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP) occurs in 3-18% of patients undergoing either diagnostic or therapeutic ERCP. We prospectively measured urinary trypsinogen activation peptides (TAP) by an automated anti-TAP enzyme-linked immunoassay among 107 patients 4 h after ERCP to determine whether this measurement helps in the early diagnosis of ERCP-induced pancreatitis. Pancreatitis was documented in 10 of 107 patients (9.3%). All episodes were graded as mild. Urinary TAP was not significantly increased. We conclude that measurement of urinary TAP 4 h after ERCP is not helpful in documenting mild ERCP-induced acute pancreatitis.
authors.affiliation: Center for Pancreatic Disease, Brigham and Women's Hospital, Harvard Medical School, Harvard School of Public Health, Boston, Massachusetts, USA.
authors.forename: P A
authors.initials: PA
authors.lastname: Banks
authors.forename: D L
authors.initials: DL
authors.lastname: Carr-Locke
authors.forename: A
authors.initials: A
authors.lastname: Slivka
authors.forename: J
authors.initials: J
authors.lastname: Van Dam
authors.forename: D R
authors.initials: DR
authors.lastname: Lichtenstein
authors.forename: M
authors.initials: M
authors.lastname: Hughes
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides / Q000652:urine*; D010195:Pancreatitis / Q000175:diagnosis* / Q000652:urine; D011446:Prospective Studies; D014362:Trypsinogen
chemical_list: D009842:Oligopeptides; C080396:trypsinogen activation peptide; D014362:Trypsinogen