[Chemotherapy for two patients with non-Hodgkin's lymphoma in hemodialysis].
There are few reports on chemotherapy of non-Hodgkin's lymphoma (NHL) in patients with chronic renal failure. Two long-term hemodialysis patients were treated for NHL with modified CHOP therapy. The plasma pharmacokinetics of adriamycin (ADR) and etoposide (VP-16) were investigated in these patients. In the first case, NHL was diagnosed in a 37-year-old male (diffuse pleomorphic, T cell type, stage I E). After 4 courses of chemotherapy, he achieved complete remission. The second case, was a 56-year-old male who was admitted to our hospital with melena and abdominal pain. A diagnosis of NHL (diffuse mixed, B cell type, stage III E) was made. Complete remission was achieved with 2 courses of chemotherapy. Levels of hematological and neurological toxicity were moderately severe but tolerable. Pharmacokinetics of ADR and VP-16 in these patients were similar to those in patients with normal renal function. These results suggested that ADR and VP-16 were effective drugs for hemodialysis patients with NHL.
Sano
F
F
First Department of Internal Medicine, St. Marianna University School of Medicine.
Koike
M
M
Ishibashi
M
M
Tuji
K
K
Katoh
M
M
Hasegawa
S
S
Maeba
T
T
Takahashi
M
M
Ohwada
S
S
Inoue
T
T
Ishida
M
M
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000493:pharmacokinetics; D004317:Doxorubicin / Q000008:administration & dosage / Q000493:pharmacokinetics; D005047:Etoposide / Q000493:pharmacokinetics; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage / Q000493:pharmacokinetics; D012074:Remission Induction; D006435:Renal Dialysis / Q000009:adverse effects*; D014750:Vincristine / Q000008:administration & dosage / Q000493:pharmacokinetics
D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone