Alteration of CaM I mRNA expression in the developing rat superior colliculus following chronic treatment with an NMDA receptor antagonist.
The spatial distribution of CaM I mRNA was investigated in the developing superior colliculus of rats that were chronically treated with the NMDA receptor antagonist AP-5. In control animals, CaM I message was localized in a continuous band of cells that extended across the entire rostro caudal axis of the superficial superior colliculus. Chronic AP-5 treatment resulted in a specific reduction of CaM I message in the caudal colliculus at postnatal day 10. Since normal NMDA receptor function has been implicated in activity dependent synaptic plasticity in the superior colliculus, these results suggest that the regulation of calmodulin may be part of a cascade of events that mediate this plasticity following NMDA receptor activation.
Berry
F B
FB
Department of Zoology, University of Toronto, Ont., Canada.
Prusky
G T
GT
Brown
I R
IR
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000818:Animals; D002147:Calmodulin / Q000235:genetics*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D017403:In Situ Hybridization; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D013477:Superior Colliculi / Q000254:growth & development / Q000502:physiology*; D013997:Time Factors
D002147:Calmodulin; D018691:Excitatory Amino Acid Antagonists; D012333:RNA, Messenger; D016194:Receptors, N-Methyl-D-Aspartate; D015763:2-Amino-5-phosphonovalerate