Pharmacokinetics of oral ranitidine in Mexicans.
The pharmacokinetics of oral ranitidine were studied in 24 Mexican male healthy volunteers. Subjects received a tablet containing 150 mg of ranitidine (Azantac, Glaxo de México, Mexico City) after an overnight fast and blood samples were drawn at several times for a period of 24 h. Ranitidine concentration in plasma was measured by high performance liquid chromatography and pharmacokinetic parameters were determined by non-compartmental analysis. Ranitidine plasma concentration increased with time, reaching a maximum of (mean +/- SEM) 484 +/- 34 ng/ml in 2.7 +/- 0.2 h. Plasma levels then decayed with a terminal half-life of 4.8 +/- 0.3 h. The area under the plasma concentration against time curve was 2440 +/- 126 ngh/ml. Oral ranitidine pharmacokinetic parameters in Mexicans appeared to be similar to those previously reported for Caucasians.
Castañeda-Hernández
G
G
Departamento de Farmacología y Toxicología, Centro de Investigación y de Estudios Avanzados del IPN, México, D.F.
Flores-Murrieta
F J
FJ
Granados-Soto
V
V
Herrera-Abarca
A
A
Pérez-Urizar
J
J
Herrera
J E
JE
Hong
E
E
D000284:Administration, Oral; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D005006:Ethnicity; D006207:Half-Life; D006801:Humans; D008297:Male; D008800:Mexico; D011899:Ranitidine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013607:Tablets
D013607:Tablets; D011899:Ranitidine