Prevention of cocaine-induced hyperactivity by a naloxone isomer with no opiate antagonist activity.
Dextro-naloxone [(+)-naloxone], an isomer with almost no opiate antagonist activity and no effect on spontaneous locomotor activity, can reduce cocaine-induced hyperactivity in mice. The classical opiate antagonist, levo-naloxone [(-)-naloxone], is known to counteract the excitatory motor effects of amphetamine and cocaine, but it has been tacitly assumed that this action of levo-naloxone is dependent on its ability to antagonize endogenous opioids. Our finding that a naloxone isomer with little or no opioid antagonist activity is also able to inhibit the cocaine effect on spontaneous motility, calls for a reconsideration of this assumption.
Chatterjie
N
N
New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA.
Alexander
G J
GJ
Sechzer
J A
JA
Lieberman
K W
KW
D000818:Animals; D003042:Cocaine / Q000037:antagonists & inhibitors*; D006948:Hyperkinesis / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology; D013237:Stereoisomerism
D009292:Narcotic Antagonists; D009270:Naloxone; D003042:Cocaine