Inositol 1,4,5-trisphosphate receptors and calcium signaling.
Many cellular responses to extracellular stimuli are mediated by the second messenger inositol 1,4,5-trisphosphate (InsP3). InsP3 releases Ca2+ from intracellular stores by binding to an InsP3 receptor (InSP3R), which is an InsP3-gated Ca2+ release channel. The resultant increase in the cytoplasmic Ca2+ concentration modulates various cellular functions, such as gene expression, metabolism, proliferation, secretion, and neural excitation. In these signaling cascades, InsP3R works as a signal converter from InsP3 to Ca2+. We describe here structural and functional properties and localization of InsP3R, a key molecule in the Ca2+ signaling pathway.
Michikawa
T
T
Department of Molecular Neurobiology, University of Tokyo, Japan.
Miyawaki
A
A
Furuichi
T
T
Mikoshiba
K
K
D000818:Animals; D002118:Calcium / Q000502:physiology*; D015220:Calcium Channels / Q000378:metabolism*; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism*; D053496:Inositol 1,4,5-Trisphosphate Receptors; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D015220:Calcium Channels; C506926:ITPR1 protein, human; D053496:Inositol 1,4,5-Trisphosphate Receptors; D018160:Receptors, Cytoplasmic and Nuclear; D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium