Paraneoplastic intestinal pseudo-obstruction, mononeuritis multiplex, and sensory neuropathy/neuronopathy.
A patient with diffuse intestinal pseudo-obstruction consisting of gastric paresis and impaired small and large bowel motility, mononeuropathy multiplex, and sensory neuropathy/neuronopathy was found to have small-cell carcinoma of the lung. The clinical symptoms were thought to be consistent with paraneoplastic neuropathy, and high antineuronal and anti-calcium channel antibodies led to the diagnosis of small-cell carcinoma of the lung. Identification of paraneoplastic neuropathy is important, because early treatment may halt the progression of the underlying carcinoma.
Simpson
D A
DA
Michigan Institute for Neurological Disorders, Farmington Hills 48334, USA.
Pawlak
A M
AM
Tegmeyer
L
L
Doig
C
C
Cox
D
D
D000368:Aged; D018288:Carcinoma, Small Cell / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D008175:Lung Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D010525:Peripheral Nerves / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D012677:Sensation