Selective suppression of in vitro T-dependent humoral immunity by synthetic food additive antioxidants.
Effect of antioxidants on humoral immune responses, such as butylated hydroxytoluene (BHT), n-propyl gallate (PG) and dimethyl sulfoxide (DMSO) is suppression in vitro antibody production. These antioxidants all inhibited T-dependent B cell response, not T-independent and polyclonal B cell response. These data suggest that antioxidants suppress humoral immunity by suppression of regulation of T cells or action of macrophages on B cells, not by direct suppression of B cells. The other possible explanation for antioxidant action is the lack of T-B cell contact required for the triggering of the B cell response with T-dependent antigens.
Kim
H M
HM
Korea Research Institute of Bioscience and Biotechnology, Taejon City.
Han
S B
SB
Chang
W I
WI
Hyun
B H
BH
Oh
G T
GT
Ahn
C J
CJ
Cha
Y N
YN
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000975:Antioxidants / Q000633:toxicity*; D002084:Butylated Hydroxytoluene / Q000633:toxicity*; D004121:Dimethyl Sulfoxide / Q000633:toxicity*; D005520:Food Preservatives / Q000633:toxicity*; D051379:Mice; D011435:Propyl Gallate / Q000633:toxicity*; D013154:Spleen / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects*
D000975:Antioxidants; D005520:Food Preservatives; D002084:Butylated Hydroxytoluene; D011435:Propyl Gallate; D004121:Dimethyl Sulfoxide