[A study of relation between pulmonary function and bronchial hypersensitivity in severe asthmatic children].
We studied 198 acetylcholine inhalation tests in 31 subjects and 260 exercise loading tests in 43 subjects, who were severe asthmatic children received institutional therapy. Respiratory threshold to acetylcholine (RT-Ach) were significantly lower when %V50 or %MMF were less than 60%. %V50 were significantly lower when EIB (maximum %fall in FEV1.0 after exercise) were more than 15%. These results suggest that in bronchial hypersensitivity tests, %V50 and %MMF which are indexes of peripheral airway obstruction should be examined.
Matsuda
S
S
Department of Pediatrics, National Higashi Saitama Hospital.
Sugimoto
H
H
Iikura
Y
Y
D000109:Acetylcholine; D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D012129:Respiratory Function Tests
D000109:Acetylcholine