Agranulocytosis, plasmacytosis, and thrombocytosis followed by a leukemoid reaction due to acute acetaminophen toxicity.
OBJECTIVE
To describe a patient who developed hepatotoxicity, reactive plasmacytosis with thrombocytosis and life-threatening agranulocytosis, followed by a leukemoid reaction, apparently caused by acute acetaminophen toxicity.


METHODS
University-affiliated hospital.


METHODS
A 19-year old white women who took an overdose of acetaminophen developed hepatotoxicity and reactive plasmacytosis with thrombocytosis and life-threatening agranulocytosis, followed by a leukemoid reaction. Symptoms, signs, and laboratory findings regressed with symptomatic therapy during the follow-up period.


CONCLUSIONS
We believe that acute acetaminophen toxicity was responsible for these hematologic abnormalities. This profile of hematologic adverse effects associated with acetaminophen toxicity has not been reported previously.
Gürsoy
M
M
Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey.
Haznedaroğlu
I C
IC
Celik
I
I
Sayinalp
N
N
Ozcebe
O I
OI
Dündar
S V
SV
D000082:Acetaminophen / Q000009:adverse effects*; D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy; D000583:Amikacin / Q000008:administration & dosage; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001853:Bone Marrow / Q000473:pathology*; D002442:Ceftazidime / Q000008:administration & dosage; D002511:Cephalosporins / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007955:Leukemoid Reaction / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy; D008099:Liver / Q000187:drug effects / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology*; D013922:Thrombocytosis / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy
D018712:Analgesics, Non-Narcotic; D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000082:Acetaminophen; D000583:Amikacin; D002442:Ceftazidime