Ethanol ingestion decreases superoxide dismutase activity and diminishes -SH compounds in the liver and red blood cells in rats.
SOD activity and -SH compounds in the liver and RBCs, and some hematological parameters were investigated in control rats and in those submitted to chronic (3 months) intoxication with ethanol. We found significantly lower SOD activity and a decrease in -SH groups in the liver and RBCs of ethanol-treated rats in comparison with the control group. The hemoglobin content and mean corpuscular hemoglobin concentration were reduced, while mean corpuscular volume of RBCs was increased when compared with the control group.
Farbiszewski
R
R
Department of Inorganic and Analytical Chemistry, Medical Academy of Białystok.
Makarewicz
M
M
Chwiecko
M
M
Kowalczyk
T
T
D000435:Alcoholic Intoxication / Q000378:metabolism; D000818:Animals; D004906:Erythrocyte Count / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology; D000431:Ethanol / Q000494:pharmacology*; D006454:Hemoglobins / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013438:Sulfhydryl Compounds / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000187:drug effects*
D006454:Hemoglobins; D013438:Sulfhydryl Compounds; D000431:Ethanol; D013482:Superoxide Dismutase