[The role of erythropoietin in erythropoiesis regulation in fetuses and newborn infants].
In fetus life erythropoiesis takes place in yolk sack first, then in liver and after that in bone marrow. The regulation of that process still remains unknown. Erythropoietin participates in liver erythropoiesis and in bone marrow. Polycythemia which appears in newborns after delivery is the result of fetus hypozemic metabolic constellation, which leads to excessive erythropoietin production. The substitution of HbF biosynthesis way to HbA (indicating higher tissue then HbF oxygen-exchange ability) is supposedly the reason of EPO secretion drop after delivery. During first 2-3 months of newborn life EPO secretion stimulation takes place at a lower then adults' blood Hb concentration.
Ulman
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IV Katedry i Kliniki Połoznictwa i Ginekologii Sl.AM w Tychach.
D001853:Bone Marrow / Q000196:embryology; D004920:Erythropoiesis / Q000502:physiology*; D004921:Erythropoietin / Q000502:physiology*; D005333:Fetus / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn / Q000502:physiology*; D007668:Kidney / Q000502:physiology; D008099:Liver / Q000196:embryology; D011086:Polycythemia / Q000503:physiopathology
D004921:Erythropoietin