title: Effects of monoclonal anticardiolipin antibody on pregnant mice.
abstract: OBJECTIVE
  To clarify the effects of anticardiolipin antibodies (aCL) on pregnancy.
  
  
  METHODS
  Monoclonal aCL obtained from MRL/lpr mice was administered to pregnant BALB/c mice and changes in the outcome of pregnancy were evaluated.
  
  
  RESULTS
  The pregnant BALB/c mice injected with monoclonal aCL showed a higher intrauterine fetal death rate than controls, but there were no significant differences in platelet counts. We observed signs of placental infarction only in the placenta of the treated pregnant BALB/c mice.
  
  
  CONCLUSIONS
  The intrauterine fetal deaths may have been due to thrombosis.
authors.affiliation: Second Department of Internal Medicine, Chiba University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Takabayashi
authors.forename: K
authors.initials: K
authors.lastname: Ichikawa
authors.forename: I
authors.initials: I
authors.lastname: Itou
authors.forename: N
authors.initials: N
authors.lastname: Ishiguro
authors.forename: T
authors.initials: T
authors.lastname: Yoshiki
authors.forename: T
authors.initials: T
authors.lastname: Koike
mesh_terms: D000818:Animals; D017153:Antibodies, Anticardiolipin / Q000276:immunology / Q000494:pharmacology*; D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000494:pharmacology*; D001808:Blood Vessels / Q000473:pathology; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D009336:Necrosis; D010976:Platelet Count / Q000187:drug effects; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects* / Q000276:immunology; D013927:Thrombosis / Q000209:etiology
chemical_list: D017153:Antibodies, Anticardiolipin; D000911:Antibodies, Monoclonal