Cholecystokinin depolarizes neurons of cat pancreatic ganglion.
The effect of cholecystokinin octapeptide (CCK-8) on membrane potential and conductance of cat pancreatic ganglion neurons was studied in vitro by means of intracellular microelectrode recording methods. Microejection of S-CCK-8 and NS-CCK-8 evoked, by direct action, a slow, reversible membrane depolarization. The majority of neurons tested were more sensitive to S-CCK-8. The depolarizing response to S-CCK-8 and NS-CCK-8 was accompanied in different neurons by a variable change in membrane permeability to Na+ and/or K+. The effects of S-CCK-8 and NS-CCK-8 were mediated by the CCKB receptor. The results suggest that S-CCK-8 and NS-CCK-8 increase the excitability of pancreatic ganglion neurons by acting on postsynaptic CCKB receptors.
Ma
R C
RC
Department of Physiology and Biophysics, Mayo Clinic, Rochester, MN 55905, USA.
Szurszewski
J H
JH
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002412:Cations / Q000737:chemistry; D002415:Cats; D002712:Chlorides / Q000737:chemistry; D005726:Ganglia, Parasympathetic / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D005730:Ganglionic Blockers / Q000494:pharmacology; D018738:Hexamethonium / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008845:Microinjections; D009431:Neural Conduction / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D018697:Nootropic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D010179:Pancreas / Q000294:innervation* / Q000502:physiology; D010276:Parasympatholytics / Q000494:pharmacology; D012844:Sincalide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*
C090019:8-sulfocholecystokinin octapeptide; D002412:Cations; D002712:Chlorides; D005730:Ganglionic Blockers; D018697:Nootropic Agents; D010276:Parasympatholytics; D018738:Hexamethonium; D001285:Atropine; D012844:Sincalide