[Testing lipid metabolism in aortic walls of rats subjected to year-long cadmium intoxication].
The present work is continuation of experiments previously conducted on the impact of cadmium on the aortic lipid metabolism of rats. In the present experimental model, the duration of exposure to cadmium was increased four-fold: that is, to twelve months. The extension of the time of exposure was intended to make possible a more detailed analysis of aortic lipid metabolism. This metabolism was traced by marking the level of free fatty acids, triglycerides, phospholipids, and total cholesterol. The cadmium content of aortic segments was marked at the same time. Out of all the lipid components marked, there was observed a statistically extremely significant increase in the concentration of free fatty acids, while the remaining lipid compounds were unchanged. The year-long toxication caused a perceptible and statistically significant concentration of cadmium in the aortic wall. The changes in lipid metabolism found in the present experimental model, in comparison to the results attained in animals subjected to three months of toxication, are relatively slight. This test result may be the consequence of the exceptionally high capacity of rats to adapt to pathogenic factors, and the development of a certain level of tolerance to cadmium in these animals.
Janik
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A
Katedra Patofizjologii Zakład Patofizjologii Doświadczalnej Collegium Medicum UJ w Krakowie.
Grabowska-Maślanka
H
H
D000818:Animals; D001011:Aorta / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D001158:Arteries / Q000187:drug effects* / Q000378:metabolism; D002104:Cadmium / Q000032:analysis / Q000633:toxicity*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006973:Hypertension / Q000139:chemically induced; D050356:Lipid Metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D005230:Fatty Acids, Nonesterified; D002104:Cadmium