Increased serum interleukin-6 level and reduction of hepatic acute-phase response after major hepatectomy.
It has been proposed that a major hepatectomy impairs the liver-related host defense mechanism. The changes in the levels of serum inflammatory cytokines and plasma acute-phase proteins synthesized in the liver were measured after partial hepatectomy. Peak levels of serum interleukin-6 were significantly higher after extended lobectomy than after lobectomy or segmentectomy (p < 0.01). Serum interleukin-1 beta and tumor necrosis factor alpha levels showed no significant changes. Plasma levels of acute-phase proteins were significantly lower after lobectomy or extended lobectomy (p < 0.05). A reduced hepatic acute-phase response probably renders patients liable to infection after major hepatectomy.
Kimura
F
F
Department of Surgery, Omiya Red Cross Hospital, Saitama, Japan.
Miyazaki
M
M
Suwa
T
T
Kakizaki
S
S
Itoh
H
H
Kaiho
T
T
Nakajina
N
N
D000209:Acute-Phase Proteins / Q000096:biosynthesis*; D000210:Acute-Phase Reaction / Q000097:blood* / Q000473:pathology; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D005260:Female; D006498:Hepatectomy; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008107:Liver Diseases / Q000097:blood* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged
D000209:Acute-Phase Proteins; D015850:Interleukin-6