title: Effects of alpha 2-agonists on intrauterine pressure and sedation in horses: comparison between detomidine, romifidine and xylazine.
abstract: The effect of three alpha 2-agonistic sedatives, Detomidine (0.04 mg/kg), Romifidine (0.08 mg/kg) Xylazine (1.1 mg/kg) and placebo (NaCl), on intrauterine pressure was investigated with an intrauterine balloon model in four non-pregnant warmblood mares. Within 6.0 (+/- 2.2) min mean pressure increases of 9.80 (+/- 3.74), 6.88 (+/- 3.95) and 13.95 (+/- 5.19) mmHg were recorded for Detomidine, Romifidine and Xylazine, respectively. Placebo had no significant effect. The mean duration of pressure increase was 30.0 (+/- 5.10), 17.67 (+/- 9.87) and 19.50 (+/- 13.78) min for Detomidine, Romifidine and Xylazine, respectively. There was no significant difference in the degree and duration of sedation between the three treatment groups. It is concluded that alpha 2-agonists exert a marked pressure increase in the uterus with no statistically significant differences in degree and duration between the three substances. With equipotent doses no difference in duration and degree of sedation could be calculated.
authors.affiliation: Klinik für Nutztiere und Pferde, Veterinärmedizinische Fakultät, Universität Bern, Switzerland.
authors.forename: U
authors.initials: U
authors.lastname: Schatzmann
authors.forename: H
authors.initials: H
authors.lastname: Jossfck
authors.forename: J L
authors.initials: JL
authors.lastname: Stauffer
authors.forename: L
authors.initials: L
authors.lastname: Goossens
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D005260:Female; D006736:Horses / Q000502:physiology*; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology; D011312:Pressure; D014599:Uterus / Q000187:drug effects* / Q000502:physiology; D014991:Xylazine / Q000494:pharmacology*
chemical_list: D000316:Adrenergic alpha-Agonists; D000777:Anesthetics; D006993:Hypnotics and Sedatives; D007093:Imidazoles; D014991:Xylazine; C041255:detomidine; C076257:romifidine