Discovery and study of Leishmania turanica for the first time in China.
Reported are the results of multidisciplinary studies on Leishmania turanica, which was isolated from the auricular tissues of naturally infected great gerbils in Xinjiang, China. Discussed are the biology of the parasite, its molecular biology, its pathogenicity in rodents and humans and its vectors. This was the first time that L. turanica had been reported in China. L. turanica is highly pathogenic in BALB/c mice, with the resulting systemic infection being lethal, and it causes dermal lesions in Meriones unguiculatus. L. turanica parasitizes the macrophages in the interstitium of the testes of Cricetulus barabensis, and entirely destroys the Leydig's cells of severely infected animals. Inoculation of L. turanica can induce simian and human cutaneous leishmaniasis. The cell membrane and flagella of the promastigotes of L. turanica have rather active ACPase. The major vectors of L. turanica were Phlebotomus mongolensis and P. andrejevi.
Guan
L R
LR
Institute of Parasitic Diseases (IPD), Chinese Academy of Preventive Medicine (CAPM), Shanghai, China.
Yang
Y Q
YQ
Qu
J Q
JQ
Shen
W X
WX
D000818:Animals; D002681:China; D005849:Gerbillinae / Q000469:parasitology*; D000882:Haplorhini / Q000469:parasitology; D006801:Humans; D007303:Insect Vectors / Q000469:parasitology; D007891:Leishmania / Q000145:classification* / Q000472:pathogenicity / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C / Q000469:parasitology; D011576:Psychodidae / Q000469:parasitology