Locomotor response to novelty does not predict cocaine place preference conditioning in rats.
Previous studies have demonstrated that rats showing a strong locomotor response to a novel environment have a greater locomotor response to psychostimulant drugs and more rapidly acquire intravenous self-administration of amphetamine. In this report, we examined whether these high-responder (HR) rats would develop place-preference conditioning with cocaine more readily than low-responder (LR) rats. Neither group of rats developed conditioned place preference for cocaine, 2.5 mg/kg, intraperitoneally (IP). Both groups of rats developed conditioned place preference for cocaine, 5.0 and 15 mg/kg, IP. However, we could not find any evidence of enhanced conditioning in the HR rats. HR rats did show a greater locomotor response to cocaine, 15 mg/kg, IP, and the locomotor response of HR and LR rats to cocaine correlated with their response to a novel environment. We conclude that using the place-preference procedure, HR and LR rats do not differ in the rewarding effect of cocaine.
Gong
W
W
Department of Psychology, Emory University, Atlanta, GA 30322, USA.
Neill
D B
DB
Justice
J B
JB
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D003042:Cocaine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects*; D018491:Dopamine Agonists / Q000494:pharmacology; D018765:Dopamine Uptake Inhibitors / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects*; D005894:Panax; D010946:Plants, Medicinal; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D012503:Saponins / Q000494:pharmacology*; D013239:Stereotyped Behavior / Q000187:drug effects
D018491:Dopamine Agonists; D018765:Dopamine Uptake Inhibitors; D011954:Receptors, Dopamine; D017981:Receptors, Neurotransmitter; D012503:Saponins; D003042:Cocaine; D001058:Apomorphine