title: A comparison of N-butylscopolammonium bromide and butorphanol tartrate for analgesia using a balloon model of abdominal pain in ponies.
abstract: The analgesic effect of N-butylscopolammonium bromide (0.3 mg/kg) using a balloon-induced model of colic in ponies was evaluated and compared with butorphanol tartrate (0.1 mg/kg). Eight adult ponies were used and each received both treatments during the two different trials. The order in which the treatment was received was randomly assigned. At the start of each trial, moderate abdominal pain was induced by inflation of a balloon placed in the lumen of the caecum. The ponies were evaluated every 5 minutes, and a cumulative pain score (CPS) was assigned. Two baseline measurements were recorded, followed by the administration of one of the two treatments. Assessments were continued for 60 minutes, or until moderate abdominal pain returned. Three ponies out of 8 responded to treatment with butorphanol tartrate, while 6 out of 8 ponies responded to N-butylscopolammonium bromide. There were no statistical differences in the CPS or duration of drug action between treatments.
authors.affiliation: Department of Anatomy, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
authors.forename: C E
authors.initials: CE
authors.lastname: Boatwright
authors.forename: S L
authors.initials: SL
authors.lastname: Fubini
authors.forename: Y T
authors.initials: YT
authors.lastname: Grohn
authors.forename: L
authors.initials: L
authors.lastname: Goossens
mesh_terms: D015746:Abdominal Pain / Q000188:drug therapy / Q000662:veterinary*; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D000818:Animals; D002077:Butorphanol / Q000627:therapeutic use*; D002086:Butylscopolammonium Bromide / Q000627:therapeutic use*; D002404:Catheterization / Q000009:adverse effects / Q000662:veterinary*; D003085:Colic / Q000150:complications / Q000188:drug therapy / Q000662:veterinary; D004195:Disease Models, Animal; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy* / Q000209:etiology; D006736:Horses; D008297:Male; D010276:Parasympatholytics / Q000627:therapeutic use*
chemical_list: D000701:Analgesics, Opioid; D010276:Parasympatholytics; D002086:Butylscopolammonium Bromide; D002077:Butorphanol