[Action of triterpene glycosides of the dammarane series and their aglycones on the K+ and H+ ion currents in erythrocytes, induced by the ionophore A23187 and divalent ions].
The influence of the dammarane triterpene glycosides Rb1, Rb2, Rg1 and Rf and their aglycones 20(S) protopanaxatriol and 20(S) protopanaxadiol on fluctuation of the K+ and H+ flows in erythrocytes induced by ionophore A23187 and Ca2+ was studied. It was shown that glycoside Rb1 (10 to 50 micrograms/ml) and 20(S) protopanaxatriol (30 micrograms/ml) had a property of inducing fluctuation of the K+ and H+ flows in erythrocytes. In case of Rb1 the system entirely reversed to the initial state whereas in case of the protopanaxatriol use after the fluctuation the system did not reverse to the initial state. Glycosides Rb2 (10 to 30 micrograms/ml), Rg1 (5 to 20 micrograms/ml) and Rf (10 to 100 micrograms/ml) and 20(S) protopanaxadiol (30 micrograms/ml) in the concentrations used did not initiate the fluctuations. The above substances increased the extracellular concentration of K+ and pH without the system reversion to the initial state.
Kim
Iu A
IuA
Department of Biochemical Pharmacology, Institute of Ginseng and Tobacco, Taejon, Korea.
Abdrasilov
B S
BS
Nurieva
R I
RI
Pak
Kh D
KhD
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D004365:Drugs, Chinese Herbal; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D036145:Ginsenosides; D006027:Glycosides / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects; D007476:Ionophores / Q000494:pharmacology; D005894:Panax / Q000737:chemistry; D010946:Plants, Medicinal; D015221:Potassium Channels / Q000187:drug effects; D011522:Protons; D051381:Rats; D017208:Rats, Wistar; D012502:Sapogenins / Q000494:pharmacology*; D012503:Saponins / Q000494:pharmacology; D014315:Triterpenes / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D006027:Glycosides; D007473:Ion Channels; D007476:Ionophores; D015221:Potassium Channels; D011522:Protons; D012502:Sapogenins; D012503:Saponins; D014315:Triterpenes; C081552:protopanaxatriol; D000001:Calcimycin; C062916:protopanaxadiol