title: Synthesis and antiviral activities of 9-cyclopentylpurine derivatives.
abstract: The synthesis and anti-RSV (Rouse Sarcoma Virus) activity of HMCA, (+/-)-9-(2-hydroxymethyl-cyclopenthyl)-adenine, and its derivatives are described. It has been demonstrated that trans-HMCA has greater anti-RSV activity in tissue culture than cis-HMCA.
authors.affiliation: Biochemistry Section, Iwakuni Research Laboratory of Technology, Nippon Paper Industries Co. Ltd, Yamaguchi, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Kojima
authors.forename: K
authors.initials: K
authors.lastname: Ohta
authors.forename: S
authors.initials: S
authors.lastname: Miyawaki
authors.forename: T
authors.initials: T
authors.lastname: Date
authors.forename: M
authors.initials: M
authors.lastname: Machida
authors.forename: K
authors.initials: K
authors.lastname: Murakami
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001358:Avian Sarcoma Viruses / Q000187:drug effects; D002642:Chick Embryo; D004353:Drug Evaluation, Preclinical; D005347:Fibroblasts; D015497:HIV-1 / Q000187:drug effects; D066298:In Vitro Techniques; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D000225:Adenine