Tetrasomy 8 and t(1;11)(p32;q24) in acute myelo-monocytic leukemia with extensive leukemic cutaneous involvement.
We report a case of tetrasomy 8 in a patient suffering from acute myelomonocytic leukemia with extensive leukemic cutaneous infiltration. In all metaphases analyzed t( I;11)(p32;q24) was concomitantly observed. Similarly to other cases with tetrasomy 8, the patient showed monocytic involvement and poor response to chemotherapy. We conclude that this kind of cytogenetic aberration is associated with distinct morphologic and clinical features.
Ferrara
F
F
Division of Hematology, Cardarelli Hospital, Naples, Italy.
Cancemi
D
D
Friso
P
P
Gaglione
M
M
Picardi
A
A
Rossi
L
L
Scognamiglio
M
M
D000368:Aged; D000782:Aneuploidy; D002878:Chromosomes, Human, Pair 1 / Q000648:ultrastructure*; D002880:Chromosomes, Human, Pair 11 / Q000648:ultrastructure*; D002898:Chromosomes, Human, Pair 8; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007621:Karyotyping; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics* / Q000473:pathology*; D017254:Leukemic Infiltration; D008297:Male; D012867:Skin / Q000473:pathology*; D014178:Translocation, Genetic