Intestinal perforation 14 years after abdominal irradiation and chemotherapy for Wilms tumor.
A 3-year-old girl underwent left nephrectomy and removal of a tumor thrombus from the inferior vena cava and right atrium in 1978 because of Wilms tumor. Her treatment consisted of tumor bed irradiation (4,000 cGy) and chemotherapy with actinomycin D, vincristine, and doxorubicin. The patient underwent laparotomy 2 months after completion of abdominal irradiation to relieve intestinal obstruction. Fourteen years later, she underwent another laparotomy because of an "acute abdomen" and was found to have perforation of the jejunum in the radiation field. Histopathological examination of resected intestine revealed evidence of severe chronic radiation enteritis, A diagnosis of chronic radiation enteritis should be considered in patients who had received abdominal irradiation and who manifest abdominal pain/vomiting even several years after irradiation.
Rao
S P
SP
Children's Medical Center of Brooklyn, NY, USA.
Anderson
V
V
Shlasko
E
E
Miller
S T
ST
Choi
K
K
Rabinowitz
S
S
D000005:Abdomen / Q000528:radiation effects; D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004751:Enteritis / Q000150:complications / Q000209:etiology; D005260:Female; D006801:Humans; D007416:Intestinal Perforation / Q000209:etiology* / Q000473:pathology; D007579:Jejunal Diseases / Q000209:etiology* / Q000473:pathology; D011832:Radiation Injuries / Q000209:etiology* / Q000473:pathology; D013997:Time Factors; D009396:Wilms Tumor / Q000188:drug therapy* / Q000532:radiotherapy*