Solution conformation of tuftsin.
Conformation of chemically synthesized tetrapeptide tuftsin, an important immunomodulator, with the sequence Thr-Lys-Pro-Arg-OH has been studied in aqueous solution as well as in a number of organic solvents viz. trifluoroethanol (TFE), methanol and dioxane by circular dichroism (CD) spectroscopy which reveals preferential occurrence of mixture of random coil and beta-turns, that has already been predicted as bioactive conformation of this peptide.
Siddiqui
M Z
MZ
Peptide Synthesis Laboratory (NBC), Indian Veterinary Research Institute, Uttar Pradesh, India.
Sharma
A K
AK
Kumar
S
S
D002942:Circular Dichroism; D000432:Methanol; D011487:Protein Conformation; D012996:Solutions; D014405:Tuftsin / Q000737:chemistry*; D014867:Water
D012996:Solutions; D014867:Water; D014405:Tuftsin; D000432:Methanol