title: Interaction between sleep and growth hormone. Evaluated by manual polysomnography and automatic power spectrum analysis.
abstract: The relation between nightly growth hormone (GH) secretion and sleep is poorly understood. To examine whether disturbances in GH secretion are reflected in abnormal sleep patterns 8 subjects with isolated GH deficiency and 9 subjects with excess of GH (acromegalics) underwent all night sleep studies, polysomnography. Moreover, the effect of correcting GH concentration on sleep patterns were examined in the same subjects. The results showed that all subjects with GH disturbances had abnormal REM and delta sleep and normalization of GH concentration was followed by correction of the sleep stages. By power spectrum analysis of the sleep EEG it was showed that during low GH concentration the sleep energy was low, and high GH concentration was associated with high sleep energy, and correction of abnormal plasma GH levels resulted in normalization of REM and delta sleep energy per time unit.
authors.affiliation: Department of Clinical Neurophysiology, National Hospital, Rigshospitalet, Copenhagen, Denmark.
authors.forename: C
authors.initials: C
authors.lastname: Aström
mesh_terms: D000328:Adult; D003700:Delta Rhythm; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D013007:Growth Hormone-Releasing Hormone / Q000378:metabolism; D006801:Humans; D007223:Infant; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism* / Q000503:physiopathology; D017286:Polysomnography; D011446:Prospective Studies; D011863:Radioimmunoassay; D012895:Sleep, REM; D013004:Somatostatin / Q000378:metabolism
chemical_list: D013004:Somatostatin; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone