The unique, complex organization of the transcriptionally silent sperm chromatin.
The sperm nucleus contains one haploid copy of the genome that is completely transcriptionally silent and is not being replicated. Recent evidence has revealed that this "silent" chromatin nevertheless contains a complex organization at all levels. This includes DNA loop domain formation by the sperm nuclear matrix that is gene specific and highly ordered folding patterns of the chromosomes, particularly with respect to centromere and telomere positioning. Such specificity in the sperm DNA organization suggests functional requirements for their existence. As these begin to emerge, the sperm nucleus is becoming an important model for the study of the eukaryotic genome.
Ward
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WS
Division of Urology, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Zalensky
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AO
D000818:Animals; D002467:Cell Nucleus / Q000737:chemistry / Q000378:metabolism / Q000648:ultrastructure; D002843:Chromatin / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D004247:DNA / Q000737:chemistry / Q000235:genetics; D006801:Humans; D008297:Male; D008954:Models, Biological; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D011479:Protamines / Q000378:metabolism; D013094:Spermatozoa / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure; D016615:Telomere / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
D002843:Chromatin; D011479:Protamines; D004247:DNA