[D1 receptor mediates dopamine-induced enhancement of electroretinographic oscillatory potentials].
The inhibitory action of SCH 23390 (SCH, D1-antagonist) or sulpiride (SUL, D2-antagonist) on the dopamine-induced enhancement of the electroretinographic oscillatory potentials was examined in anesthetized albino rabbits. Enhancement of the oscillatory potentials by intravitreal dopamine (50 microM intravitreal concentration) injection was blocked by a simultaneous intravitreal injection of SCH (20 microM) but not by SUL (50 microM, 100 microM). These results suggest that D1-receptor is mainly responsible for the dopamine-induced enhancement of the oscillatory potentials.
Tagawa
S
S
Department of Ophthalmology, Kanazawa University School of Medicine.
Shirao
Y
Y
Tamura
T
T
Kobayashi
A
A
Katoh
K
K
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D004596:Electroretinography; D011817:Rabbits; D017447:Receptors, Dopamine D1 / Q000502:physiology*; D012160:Retina / Q000187:drug effects* / Q000502:physiology; D013469:Sulpiride / Q000494:pharmacology
D001552:Benzazepines; D018492:Dopamine Antagonists; D017447:Receptors, Dopamine D1; D013469:Sulpiride; D004298:Dopamine