title: Effect of the antiallergic drug disodium cromoglycate on phosphodiesterase activity.
abstract: The antiallergic drug disodium cromoglycate and its non-antiallergic analogue dicoumarol, inhibit the enzymatic activity of phosphodiesterase with KI values of 0.8.10(-9) M and 1.6.10(-9) M, respectively. It seems that the dichromone group is responsible for this inhibition, independently of its antiallergic effect.
authors.affiliation: Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Basque Country, Vitoria-Gasteiz, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Ochoa de Aspuru
authors.forename: A M
authors.initials: AM
authors.lastname: Zatón
mesh_terms: D015720:5'-Nucleotidase / Q000378:metabolism; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology; D002417:Cattle; D004205:Cromolyn Sodium / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism; D001728:Dicumarol / Q000031:analogs & derivatives / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D007700:Kinetics; D051379:Mice; D015394:Molecular Structure; D009206:Myocardium / Q000201:enzymology; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D012910:Snake Venoms / Q000201:enzymology
chemical_list: D018927:Anti-Asthmatic Agents; D004791:Enzyme Inhibitors; D010726:Phosphodiesterase Inhibitors; D012910:Snake Venoms; D001728:Dicumarol; D000242:Cyclic AMP; D015720:5'-Nucleotidase; D004205:Cromolyn Sodium