title: A case of hypertensive-diabetic cardiomyopathy demonstrating left ventricular wall motion abnormality.
abstract: We report a case of hypertensive-diabetic cardiomyopathy demonstrating left ventricular regional wall motion abnormality, with a normal coronary artery documented on coronary arteriography. Dipyridamole-infusion 201Tl scintigraphy demonstrated transient perfusion defects in the infero-posterior wall of the left ventricle, where reduced wall motion was demonstrated on contrast left ventriculography. Myocardial SPECT (single photon emission tomography) imaging with [123I] beta-methyliodophenylpentadecanoic acid (BMIPP) and 201Tl demonstrated reduced [123I]BMIPP uptake compared with 201Tl uptake in the infero-posterior wall of left ventricle. These results suggest that the impairment of myocardial free fatty acid metabolism is an etiologic or contributory factor for regional wall motion abnormality, together with small-vessel coronary artery disease, in this patient.
authors.affiliation: Department of Internal Medicine, Kansai Rosai Hospital, Hyogo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shimonagata
authors.forename: S
authors.initials: S
authors.lastname: Nanto
authors.forename: M
authors.initials: M
authors.lastname: Hori
authors.forename: T
authors.initials: T
authors.lastname: Ohara
authors.forename: Y
authors.initials: Y
authors.lastname: Kim
authors.forename: Y
authors.initials: Y
authors.lastname: Takano
authors.forename: K
authors.initials: K
authors.lastname: Sakamoto
authors.forename: K
authors.initials: K
authors.lastname: Kamado
authors.forename: S
authors.initials: S
authors.lastname: Kubori
authors.forename: H
authors.initials: H
authors.lastname: Kusuoka
authors.forename: T
authors.initials: T
authors.lastname: Nishimura
mesh_terms: D009202:Cardiomyopathies / Q000000981:diagnostic imaging / Q000503:physiopathology*; D017023:Coronary Angiography; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000503:physiopathology*; D004176:Dipyridamole; D004562:Electrocardiography; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D013794:Thallium Radioisotopes; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging
chemical_list: D013794:Thallium Radioisotopes; D004176:Dipyridamole