title: The role of cost-effectiveness analysis in health and medicine. Panel on Cost-Effectiveness in Health and Medicine.
abstract: OBJECTIVE
  To develop consensus-based recommendations guiding the conduct of cost-effectiveness analysis (CEA) to improve the comparability and quality of studies. The recommendations apply to analyses intended to inform the allocation of health care resources across a broad range of conditions and interventions. This article, first in a 3-part series, discusses how this goal affects the conduct and use of analyses. The remaining articles will outline methodological and reporting recommendations, respectively.
  
  
  METHODS
  The Panel on Cost-Effectiveness in Health and Medicine, a nonfederal panel with expertise in CEA, clinical medicine, ethics, and health outcomes measurement, was convened by the US Public Health Service (PHS).
  
  
  METHODS
  The panel reviewed the theoretical foundations of CEA, current practices, and alternative procedures for measuring and assigning values to resource use and health outcomes.
  
  
  METHODS
  The panel met 11 times during 2 1/2 years with PHS staff and methodologists from federal agencies. Working groups brought issues and preliminary recommendations to the full panel for discussion. Draft recommendations were circulated to outside experts and the federal agencies prior to finalization.
  
  
  CONCLUSIONS
  The panel's recommendations define a "reference case" cost-effectiveness analysis, a standard set of methods to serve as a point of comparison across studies. The reference case analysis is conducted from the societal perspective and accounts for benefits, harms, and costs to all parties. Although CEA does not reflect every element of importance in health care decisions, the information it provides is critical to informing decisions about the allocation of health care resources.
authors.affiliation: Institute for Health, Health Care Policy, and Aging Research, Rutgers University, New Brunswick, NJ, USA.
authors.forename: L B
authors.initials: LB
authors.lastname: Russell
authors.forename: M R
authors.initials: MR
authors.lastname: Gold
authors.forename: J E
authors.initials: JE
authors.lastname: Siegel
authors.forename: N
authors.initials: N
authors.lastname: Daniels
authors.forename: M C
authors.initials: MC
authors.lastname: Weinstein
mesh_terms: D026683:Advisory Committees; D003362:Cost-Benefit Analysis; D035082:Federal Government; D015276:Health Care Rationing; D006302:Health Services Research; D010043:Outcome and Process Assessment, Health Care; D019057:Quality-Adjusted Life Years; D040841:Resource Allocation; D018570:Risk Assessment; D012945:Social Values; D014481:United States