In vitro susceptibilities of Bordetella pertussis and Bordetella parapertussis to four fluoroquinolones (levofloxacin, d-ofloxacin, ofloxacin, and ciprofloxacin), cefpirome, and meropenem.
The in vitro activities of levofloxacin, ofloxacin, d-ofloxacin, ciprofloxacin, cefpirome, and meropenem against 34 clinical isolates each of Bordetella pertussis and Bordetella parapertussis were determined by agar dilution on Mueller-Hinton agar supplemented with 5% horse blood. Levofloxacin was as active as ciprofloxacin against both species (MIC, 0.06 microgram/ml) and more active than ofloxacin and d-ofloxacin. Cefpirome was more active against B. pertussis (MIC, 1.0 microgram/ml) than against B. parapertussis (MIC, > 2 micrograms/ml), while the reverse was true for meropenem (MIC, 2.0 micrograms/ml against B. pertussis and 1.0 microgram/ml against B. parapertussis).
Hoppe
J E
JE
University Children's Hospital, Tübingen, Germany.
Rahimi-Galougahi
E
E
Seibert
G
G
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001884:Bordetella / Q000187:drug effects*; D001885:Bordetella Infections / Q000382:microbiology; D001886:Bordetella pertussis / Q000187:drug effects*; D002511:Cephalosporins / Q000494:pharmacology; D024841:Fluoroquinolones; D006801:Humans; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D013845:Thienamycins / Q000494:pharmacology; D014917:Whooping Cough / Q000382:microbiology; D000097572:Cefpirome
D000890:Anti-Infective Agents; D002511:Cephalosporins; D024841:Fluoroquinolones; D000077731:Meropenem; D013845:Thienamycins; D000097572:Cefpirome