Colonization of a calcium phosphate/elastin-solubilized peptide-collagen composite material by human osteoblasts.
The evaluation of the suitability of a new biomaterial as a possible substitute for bone tissue is described here. This biomaterial is based on calcium phosphate particles linked to an artificial connective matrix, the elastin-solubilized peptides (ESP) associated with type I and III collagens. This work demonstrates the feasibility of shaping this composite material into discs, describes its microstructural characteristics, and evaluates its capacity as a substrate for the proliferation of human osteoblasts without loss of their phenotypic expression.
Rovira
A
A
CIDA (Centro de Investigacion y Desarrollo Aplicado sal) Centro Industrial Santiga, Barcelona, Spain.
Amedee
J
J
Bareille
R
R
Rabaud
M
M
D000327:Adsorption; D000469:Alkaline Phosphatase / Q000378:metabolism; D001672:Biocompatible Materials; D015415:Biomarkers; D002455:Cell Division; D003094:Collagen; D004247:DNA / Q000096:biosynthesis; D017886:Durapatite; D004549:Elastin; D006801:Humans; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000166:cytology* / Q000502:physiology*; D015675:Osteocalcin / Q000096:biosynthesis; D015676:Osteonectin / Q000096:biosynthesis; D010446:Peptide Fragments; D013936:Thymidine / Q000378:metabolism
D001672:Biocompatible Materials; D015415:Biomarkers; D015676:Osteonectin; D010446:Peptide Fragments; D015675:Osteocalcin; D003094:Collagen; D004247:DNA; D004549:Elastin; D017886:Durapatite; D000469:Alkaline Phosphatase; D013936:Thymidine