title: [Selective permeability of the glomerular filtration barrier in man].
abstract: Glomerular ultrafiltration of macromolecules is a biophysical process sharing both a diffusive and a convective component, governed by glomerular hemodynamics, through a composite structure, the glomerular filtration barrier. Studies of the fractional clearance of macromolecules have showed that transcapillary filtration of macromolecules is hindered by size, electrostatic charge and to a lesser degree by spatial conformation. Several modelizations of ultrafiltration have been developped to quantify the respective role of glomerular hemodynamic and/or membrane structural alternations as found in glomerular diseases.
authors.affiliation: Département de néphrologie, Hôpitaux Universitaires de Strasbourg.
authors.forename: P
authors.initials: P
authors.lastname: Petitjean
authors.forename: F
authors.initials: F
authors.lastname: Chantrel
authors.forename: T
authors.initials: T
authors.lastname: Hannedouche
mesh_terms: D002199:Capillary Permeability; D006801:Humans; D007678:Kidney Glomerulus / Q000098:blood supply*; D011506:Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D011506:Proteins