title: Influence of cholesterol feeding on bile acid metabolism in young and aged germ-free rats.
abstract: The effects of cholesterol feeding on serum and liver cholesterol levels, fecal and biliary bile acid levels, bile acid pool size and bile acid composition were examined in 2-, 12- and 24-month-old male germ-free rats. The major bile acids in these animals were cholic and beta-muricholic acids. Cholesterol feeding increased synthesis of bile acids by 3- to 4-fold, especially that of chenodeoxycholic acid (mainly beta-muricholic acid in the rat), decreasing the cholic acid/chenodeoxycholic acid (CA/CDCA) ratio in all rats regardless of age, even though the CA/CDCA ratio increased as a linear function of age in both diet groups. Cholesterol feeding increased the serum cholesterol level markedly in aged rats. This hypercholesterolemia may be produced by the increase in CA/CDCA ratio in aged rats.
authors.affiliation: Strategic Information Unit, Shionogi & Co., Ltd., Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Uchida
authors.forename: T
authors.initials: T
authors.lastname: Satoh
authors.forename: T
authors.initials: T
authors.lastname: Chikai
authors.forename: H
authors.initials: H
authors.lastname: Takase
authors.forename: Y
authors.initials: Y
authors.lastname: Nomura
authors.forename: H
authors.initials: H
authors.lastname: Nakao
authors.forename: N
authors.initials: N
authors.lastname: Takeuchi
mesh_terms: D000375:Aging; D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D002635:Chenodeoxycholic Acid / Q000378:metabolism; D002784:Cholesterol / Q000032:analysis; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D019826:Cholic Acid; D002793:Cholic Acids / Q000378:metabolism; D005243:Feces / Q000737:chemistry*; D005856:Germ-Free Life / Q000502:physiology*; D007420:Intestine, Large / Q000378:metabolism*; D007421:Intestine, Small / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats
chemical_list: D001647:Bile Acids and Salts; D002791:Cholesterol, Dietary; D002793:Cholic Acids; D002635:Chenodeoxycholic Acid; D002784:Cholesterol; D019826:Cholic Acid