Interleukin-7. Biology and implications for dermatology.
In recent years, it has become apparent that IL-7, originally characterized as a growth factor for pre-B lymphocytes, also has important implications for the skin. Keratinocytes have been shown to produce IL-7. which in turn can elicit a variety of biological responses on several cell types residing in the skin. IL-7 has been demonstrated to augment the cytolytic activity of cytotoxic T cells (CTL) and natural killer (NK) cells against various neoplastic targets including melanoma cells. Proliferation and long-term survival of murine dendritic epidermal T lymphocytes (DETC) in vitro is supported by IL-7. IL-7 also induces secretion of inflammatory cytokines by monocytes/macrophages and renders these cells to become tumoricidal against melanoma cells. Normal and malignant melanocytes respond to IL-7 with increased expression of intercellular adhesion molecule (ICAM-1). In addition, IL-7 has been shown to act as growth factor for Sezary cells, suggesting a role of keratinocyte-derived IL-7 in the pathogenesis of cutaneous T cell lymphoma. Because of the potent in vitro immunomodulatory effects of IL-7 which have been confirmed in mouse tumor models, IL-7 may become a valuable additional agent to immunotherapeutical regimens currently studied in patients with advanced melanoma. This review summarizes our present knowledge about the molecular and immunological properties of IL7 with emphasis on the effects of that cytokine within the cutaneous compartment and the potential clinical utility in dermatology.
Möller
P
P
Department of Dermatology, Virchow Clinic, Humboldt University, Berlin, Germany.
Böhm
M
M
Czarnetszki
B M
BM
Schadendorf
D
D
D000818:Animals; D015703:Antigens, CD / Q000502:physiology; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D015851:Interleukin-7 / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use*; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology; D008544:Melanocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D008545:Melanoma / Q000473:pathology / Q000628:therapy*; D051379:Mice; D018123:Receptors, Interleukin / Q000502:physiology; D020395:Receptors, Interleukin-7; D016201:Receptors, Lymphocyte Homing / Q000276:immunology; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D015703:Antigens, CD; D015851:Interleukin-7; D018123:Receptors, Interleukin; D020395:Receptors, Interleukin-7; D016201:Receptors, Lymphocyte Homing