Levels of lipoprotein(a) and plasma lipids in Spanish children aged from 4 to 18 years.
Increased plasma lipoprotein(a)-Lp(a)-levels are linked to a high risk of cardiovascular disease unrelated to other lipoproteins. It seems that Lp(a) values in childhood remain unaltered up to adulthood. In a randomly chosen population of 1970 children, aged from 4 to 18 years and living in a Spanish community, the following serum parameters were studied: total cholesterol, total triglycerides, Lp(a), high-density lipoprotein cholesterol and low-density lipoprotein cholesterol. Mean Lp(a) serum values were 15.0 +/- 14.7 mg dl-1. No differences were seen between either sex in the first years of childhood. Of the studied children, 15.1% presented Lp(a) concentrations above 30 mg dl-1. A correlation between Lp(a) and total cholesterol concentrations, which disappeared when low-density lipoprotein cholesterol concentrations were corrected according to cholesterol present in Lp(a), was observed.
Gómez Gerique
J A
JA
Departamento de Bioquímica Clínica, Fundación Jiménez Díaz, Madrid, Spain.
Porres
A
A
López Martinez
D
D
Alvarez Sala
L A
LA
Blazquez
E
E
Montoya
M T
MT
De Oya
M
M
D000293:Adolescent; D002648:Child; D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015331:Cohort Studies; D003431:Cross-Cultural Comparison; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D012016:Reference Values; D012494:Sampling Studies; D013030:Spain / Q000453:epidemiology
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D017270:Lipoprotein(a); D002784:Cholesterol