Proposal for use of a standard side effect scoring system in studies exploring Helicobacter pylori treatment regimens.
Many antibiotic regimens for treating Helicobacter pylori infection are currently used in clinical trials. The reported side-effect profiles of similar anti-Helicobacter therapies vary widely due to the use of different scoring systems. Therefore side-effect data from separate studies cannot be compared. Only randomized controlled trials will show how side-effect profiles and tolerability really differ between regimens, but few such studies are available. Therefore a choice of treatment based on side-effect profile is not possible at present. We seek standardization of side-effect registration among investigators and propose a side-effect questionnaire which, if generally accepted, would make it possible to compare data between trials.
de Boer
W A
WA
Sint Anna Hospital, Oss, The Netherlands.
Thys
J C
JC
Borody
T J
TJ
Graham
D Y
DY
O'Morain
C
C
Tytgat
G N
GN
D016907:Adverse Drug Reaction Reporting Systems / Q000592:standards*; D000900:Anti-Bacterial Agents; D004359:Drug Therapy, Combination / Q000009:adverse effects / Q000627:therapeutic use; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans
D000900:Anti-Bacterial Agents