Centrally mediated hemodynamic effects of cocaine in rabbits: the role of local anesthetic actions and biogenic amine re-uptake blockage.
This study sought to identify the central nervous system-mediated cardiovascular effects of cocaine and to determine if these effects result from local anesthetic action or biogenic amine re-uptake blockade. New Zealand rabbits received multiple i.c.v. doses of cocaine, pseudococaine, lidocaine or desipramine while recording blood pressure and heart rate. Moderate dose cocaine produced a decrease in heart rate and mean arterial pressure while the highest dose produced increases in heart rate and blood pressure. Lidocaine and pseudococaine produced dose-dependent increases in blood pressure while desipramine produced decreases in heart rate and mean arterial pressure. In this model, the central nervous system-mediated cardiovascular effects of cocaine are dose-dependent; low doses produced cardiovascular depression while higher doses produced cardiovascular stimulation. The data also suggest that cocaine's local anesthetic effects are responsible for its central nervous system-mediated cardiovascular stimulation, while biogenic amine re-uptake blockade causes cardiovascular depression.
Bernards
C M
CM
Department of Anesthesiology, University of Washington, Seattle 98195-6540, USA.
D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D015306:Biogenic Monoamines / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002490:Central Nervous System / Q000187:drug effects* / Q000502:physiology*; D003042:Cocaine / Q000494:pharmacology*; D003891:Desipramine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D007276:Injections, Intraventricular; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D014179:Neurotransmitter Uptake Inhibitors / Q000494:pharmacology*; D011817:Rabbits
D018759:Adrenergic Uptake Inhibitors; D000779:Anesthetics, Local; D015306:Biogenic Monoamines; D014179:Neurotransmitter Uptake Inhibitors; C016084:pseudococaine; D008012:Lidocaine; D003042:Cocaine; D003891:Desipramine