title: Soluble intercellular adhesion molecule-1 in colorectal cancer and its relationship to acute phase proteins.
abstract: Increased concentrations of soluble intercellular adhesion molecule-I (ICAM-1) have been reported in a number of diseases including cancer. This study was undertaken to evaluate soluble ICAM-1 in colorectal cancer and its relationship to an unspecific acute phase response. Fifty six patients (25 with advanced colorectal cancer and 31 out-patients after radical surgical treatment) were included. Soluble ICAM-1 was measured by enzyme immunoassay. Four acute phase proteins (C-reactive protein, acid alpha 1-glycoprotein, haptoglobin and ceruloplasmin) were estimated by immuno-nephelometry. No significant increase of soluble ICAM-1 could be demonstrated in the patients compared to a control group (median 273 ng/ml vs. 270 ng/ml). Furthermore, patients with advanced colorectal cancer did not demonstrate elevated soluble ICAM-1 compared to follow-up out-patients. Patients with present acute phase response as determined by C-reactive protein were shown to have increased soluble ICAM-1 compared to patients without acute phase reaction. Using other acute phase proteins no difference for soluble ICAM-1 has been shown. Our data suggest an association between acute phase response and increased ICAM-1 in patients with colorectal cancer which should be considered when the diagnostic and/or prognostic usefulness of soluble ICAM-1 is to be evaluated.
authors.affiliation: Institute of Clinical Chemistry and Pathobiochemistry, Faculty of Medicine, University of Rostock, FRG.
authors.forename: K M
authors.initials: KM
authors.lastname: Reinhardt
authors.forename: M
authors.initials: M
authors.lastname: Steiner
authors.forename: D
authors.initials: D
authors.lastname: Zillig
authors.forename: H R
authors.initials: HR
authors.lastname: Nagel
authors.forename: A D
authors.initials: AD
authors.lastname: Blann
authors.forename: W
authors.initials: W
authors.lastname: Brinckmann
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis*; D000210:Acute-Phase Reaction / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000097:blood* / Q000737:chemistry; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012995:Solubility
chemical_list: D000209:Acute-Phase Proteins; D018799:Intercellular Adhesion Molecule-1