[Mechanism of peritoneal metastasis and the possibility of therapeutic agents].
Peritoneal metastasis has been clinically considered to be a terminal stage, so aggressive therapy has not been performed. Recently, the molecular biologic study of cancer metastasis has progressed, so it should be important in the future to examine new therapies based on the mechanism of metastasis. In this paper, the mechanism of peritoneal metastasis, especially adhesion to peritoneum, was investigated using a scirrhous gastric cancer cell line, OCUM-2MD3. The possibility of therapeutic agents for the metastasis based on the mechanism was discussed.
Sowa
M
M
First Dept. of Surgery, Osaka City University Medical School, Japan.
Yashiro
M
M
Nishimura
S
S
Chung
Y S
YS
D000818:Animals; D000906:Antibodies / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000502:physiology; D006801:Humans; D018960:Hyaluronan Receptors / Q000276:immunology / Q000502:physiology; D006820:Hyaluronic Acid / Q000378:metabolism; D009362:Neoplasm Metastasis; D009842:Oligopeptides / Q000627:therapeutic use; D010534:Peritoneal Neoplasms / Q000473:pathology / Q000556:secondary*; D013274:Stomach Neoplasms / Q000473:pathology; D014407:Tumor Cells, Cultured
D000906:Antibodies; D000970:Antineoplastic Agents; D015815:Cell Adhesion Molecules; D018960:Hyaluronan Receptors; D009842:Oligopeptides; C081571:tyrosyl-isoleucyl-glycyl-seryl-arginine; D006820:Hyaluronic Acid