title: Adult respiratory distress syndrome with increased serum and bronchoalveolar lavage fluid levels of squamous cell carcinoma-related antigen.
abstract: We report a case with adult respiratory distress syndrome (ARDS) associated with increased levels of squamous cell carcinoma-related antigen (SCC) in the serum and bronchoalveolar lavage fluid (BALF). ARDS was likely induced by ibuprofen, based on the presence of pancytopenia and a weakly positive drug lymphocyte stimulating test (DLST). High serum and BALF levels of interleukin (IL)-8, neutrophil elastase as well as SCC were detected. Corticosteroid therapy resulted in clinical improvement, resolution of pulmonary infiltrates on chest roentgenogram and normalization of serum and BALF levels of IL-8, neutrophil elastase and SCC.
authors.affiliation: Third Department of Internal Medicine, Miyazaki Medical College.
authors.forename: J
authors.initials: J
authors.lastname: Ashitani
authors.forename: H
authors.initials: H
authors.lastname: Mukae
authors.forename: H
authors.initials: H
authors.lastname: Ihiboshi
authors.forename: H
authors.initials: H
authors.lastname: Taniguchi
authors.forename: H
authors.initials: H
authors.lastname: Mashimoto
authors.forename: S
authors.initials: S
authors.lastname: Matsukura
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis*; D015415:Biomarkers; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects*; D016209:Interleukin-8 / Q000032:analysis; D019272:Leukocyte Elastase / Q000097:blood; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology; D010196:Pancreatic Elastase / Q000097:blood; D010198:Pancytopenia / Q000139:chemically induced; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000378:metabolism; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000378:metabolism; D015843:Serpins
chemical_list: D000951:Antigens, Neoplasm; D015415:Biomarkers; D016209:Interleukin-8; D015843:Serpins; C051072:squamous cell carcinoma-related antigen; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase; D007052:Ibuprofen