Unusual presentation of Ewing sarcoma with t(21;22) in a 3-year-old boy.
OBJECTIVE
We describe a 3-year-old boy with widespread, metastatic Ewing sarcoma and an unusual translocation, involving chromosomes 21 and 22.


METHODS
Cytogenetic studies were performed on a biopsy of the primary tumor. These included GTG banding and fluorescence in situ hybridization.


RESULTS
A balanced translocation between chromosomes 21 and 22 was noted with translocation breakpoints at bands 21q22 and 22q12.


CONCLUSIONS
The t(21;22) translocation represents a new cytogenetic abnormality that may be associated with Ewing sarcoma. Its prognostic significance, if any, remains to be determined.
Massey
G V
GV
Department of Pediatrics, Children's Medical Center, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA.
Dunn
N L
NL
Heckel
J L
JL
Davis
E C
EC
Jackson-Cook
C
C
Russell
E C
EC
D002675:Child, Preschool; D002891:Chromosomes, Human, Pair 21; D002892:Chromosomes, Human, Pair 22; D006801:Humans; D008297:Male; D012512:Sarcoma, Ewing / Q000235:genetics*; D014178:Translocation, Genetic