Vasculitis and psoriatic arthritis associated with Down's syndrome.
Only a few observations of inflammatory arthritis have been associated with Down's syndrome. We report a case of severe erosive, peripheral and axial psoriatic arthritis associated with cutaneous vasculitis in a 24-year old man with trisomy 21. A long standing remission of vasculitis and arthritis was achieved with corticoid and azathioprine treatment. The relationship between chromosomal abnormalities and synovial proliferation is further discussed.
Jorgensen
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C
Service d'Immuno-Rhumatologie, Centre Gui-de-Chauliac, Montpellier, France.
Bologna
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C
Sany
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J
D000328:Adult; D015535:Arthritis, Psoriatic / Q000209:etiology*; D004314:Down Syndrome / Q000150:complications*; D006225:Hand / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D011859:Radiography; D017445:Skin Diseases, Vascular / Q000209:etiology; D014657:Vasculitis / Q000209:etiology*