Lack of association between schizophrenia and the apolipoprotein E epsilon 4 allele.
The association between the epsilon 4 allele of the apolipoprotein E (APOE) gene and Alzheimer's disease (AD) has been reported. In order to examine if the epsilon 4 allele may play a role also in schizophrenia, another mental disorder, patients (n = 87) and control subjects (n = 57) were genotyped for APOE. No significant difference was found between the groups. The data indicate that the APOE gene is not of major importance for the genesis of schizophrenia.
Jönsson
E
E
Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
Lannfelt
L
L
Engvall
B
B
Sedvall
G
G
D000328:Adult; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology
D001057:Apolipoproteins E