title: Lumbar chymopapain nucleolysis.
abstract: Chemonucleolysis with chymopapain is indicated in the majority of patients who are candidates for surgery for intractable sciatica due to herniated nucleus pulposus. It is safer, as effective, and cheaper than standard surgical discectomy, providing that patients are well selected and the procedure is properly performed. Because the indication for chemonucleolysis is not limited to contained discs, it has proved to be more effective than percutaneous discectomy. At present, of all percutaneous methods, lumbar chymopapain nucleolysis is the only procedure that has withstood the test of time. It is an attractive alternative to surgical discectomy and should be presented for consideration to patients who meet the criteria for the procedure.
authors.affiliation: Department of Neurological Surgery, University of Wisconsin Medical School and Clinical Science Center, Madison 53792, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Javid
authors.forename: E J
authors.initials: EJ
authors.lastname: Nordby
mesh_terms: D002917:Chymopapain / Q000627:therapeutic use*; D003362:Cost-Benefit Analysis; D006801:Humans; D007404:Intervertebral Disc Chemolysis / Q000009:adverse effects / Q000379:methods / Q000401:mortality; D007405:Intervertebral Disc Displacement / Q000628:therapy*; D007796:Laminectomy; D008159:Lumbar Vertebrae / Q000187:drug effects*; D009017:Morbidity
chemical_list: D002917:Chymopapain