title: Pharmacokinetics of lidocaine with epinephrine in piglets following epidural anaesthesia.
abstract: The time course of arterial plasma lidocaine concentration, following an epidural anaesthesia via the sacrococcygeal or the S4-S5 trans-sacral approach, was studied in nine healthy piglets (7.8 +/- 1.3 weeks). Plasma lidocaine concentrations were measured for up to six hours after administration (5 mg/kg). Peak plasma concentration was 1.83 +/- 0.17 mg/l. Pharmacokinetic parameters determined from an independent compartment model were not different from those observed after an epidural administration of lidocaine via the sacrococcygeal space in children, except for a wide variability in the time taken to reach the maximum concentration (27.3 +/- 7.4 min) and a shorter half-life of elimination (82.8 +/- 7.0 min). The total body clearance of lidocaine was similar in piglets (17.3 +/- 1.6 ml/min/kg) to that in children. The shorter half-life of elimination was therefore attributed to a smaller volume of distribution in piglets (2.0 +/- 0.2 l/kg).
authors.affiliation: Laboratory of Multivisceral Transplantation (GRTMV), INRA Le Magneraud, University of Poitiers School of Medicine, France.
authors.forename: L
authors.initials: L
authors.lastname: Lacoste
authors.forename: J
authors.initials: J
authors.lastname: Karayan
authors.forename: S
authors.initials: S
authors.lastname: Bouquet
authors.forename: J
authors.initials: J
authors.lastname: Rouffineau
authors.forename: J M
authors.initials: JM
authors.lastname: Péchier
authors.forename: J C
authors.initials: JC
authors.lastname: Caritez
authors.forename: M
authors.initials: M
authors.lastname: Carretier
authors.forename: J
authors.initials: J
authors.lastname: Fusciardi
mesh_terms: D000767:Anesthesia, Epidural / Q000662:veterinary*; D019162:Anesthetics, Combined / Q000097:blood / Q000493:pharmacokinetics*; D000779:Anesthetics, Local / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D004350:Drug Residues / Q000032:analysis / Q000493:pharmacokinetics*; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006207:Half-Life; D008012:Lidocaine / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D012445:Sacrococcygeal Region; D013552:Swine / Q000378:metabolism*; D013997:Time Factors
chemical_list: D019162:Anesthetics, Combined; D000779:Anesthetics, Local; D008012:Lidocaine; D004837:Epinephrine