title: Non-surgical management of early breast cancer in the United Kingdom: radiotherapy fractionation practices. Clinical Audit Sub-committee of the Faculty of Clinical Oncology, Royal College of Radiologists, and the Joint Council for Clinical Oncology.
abstract: A national survey of British radiotherapy schedules used in women with early breast cancer was undertaken to document variation in treatment practices and to consider its clinical significance. Although the variation is considerable, the analysis suggests that the majority of schedules in use are very similar in terms of treatment intensity when allowance is made for fraction size and overall time. Half the respondents used one of three dosage schedules, which probably differ very little in terms of late normal-tissue effects and tumour control from a conventional schedule giving 50 Gy in daily 2 Gy fractions. Eighty-two percent of respondents were using schedules that are equivalent to a dose of between 45 Gy and 50 Gy in 2 Gy fractions. The study suggests that the protocols in use by a minority of respondents may be unduly conservative or aggressive, and it leads to the proposal that oncologists should set up trials comparing commonly used schedules as a matter of urgency.
authors.affiliation: Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, UK.
authors.forename: J R
authors.initials: JR
authors.lastname: Yarnold
authors.forename: P
authors.initials: P
authors.lastname: Price
authors.forename: G G
authors.initials: GG
authors.lastname: Steel
mesh_terms: D001940:Breast / Q000528:radiation effects; D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D002985:Clinical Protocols; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008495:Medical Oncology; D010818:Practice Patterns, Physicians'; D055656:Prescriptions; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy; D012062:Relative Biological Effectiveness; D013997:Time Factors; D006113:United Kingdom