title: A double-blind comparative study of brofaromine and fluvoxamine in outpatients with panic disorder.
abstract: Previous studies have shown that both selective serotonin reuptake inhibitors (SSRIs) and monoamine oxidase inhibitors (MAOIs) are effective in the treatment of panic disorders (PD). In this study, the SSRI fluvoxamine (Fluv) was compared with the MAO-A-I brofaromine (Brof). Thirty patients with the diagnosis of PD with or without agoraphobia were treated with either Fluv or Brof (150 mg daily) in a double-blind design. After 12 weeks of treatment, 93% of the Brof group and 87% of the Fluv group considered themselves much or very much improved. Taking a reduction in the Hamilton Rating Scale for Anxiety score of 50% or more, 33% of the Fluv patients and 47% of the Brof patients were responders to treatment. After an increase in anxiety in the 1st week, which was more severe in Fluv-treated patients than for Brof, a clinically relevant decrease in anxiety symptoms and reduction in panic attacks and avoidance behavior was observed. There was no significant difference between the treatment groups. The most prominent side effects were middle-sleep disturbance (Brof), tiredness (Fluv), and nausea after taking the medication (Brof and Fluv). During a double-blind follow-up period of another 12 weeks, a further improvement was found in both treatment groups without significant differences between the two groups. The selective and reversible MAO-A-I brofaromine and the SSRI fluvoxamine are equally effective in the treatment of PD. Both compounds lead to a reduction in the number of panic attacks and a subsequent reduction in agoraphobic avoidance.
authors.affiliation: Department of Psychiatry, Academic Hospital Utrecht, The Netherlands.
authors.forename: I M
authors.initials: IM
authors.lastname: van Vliet
authors.forename: J A
authors.initials: JA
authors.lastname: den Boer
authors.forename: H G
authors.initials: HG
authors.lastname: Westenberg
authors.forename: B R
authors.initials: BR
authors.lastname: Slaap
mesh_terms: D000328:Adult; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D016666:Fluvoxamine / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D006261:Headache / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use*; D009325:Nausea / Q000139:chemically induced; D016584:Panic Disorder / Q000097:blood / Q000188:drug therapy*; D010880:Piperidines / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
chemical_list: D014151:Anti-Anxiety Agents; D016666:Fluvoxamine; D008996:Monoamine Oxidase Inhibitors; D010880:Piperidines; D017367:Selective Serotonin Reuptake Inhibitors; C038213:brofaromine