Expression of E-cadherin in skin carcinomas.
In this study, we investigated the expression of E-cadherin in 31 cases of human skin carcinoma including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), Paget's disease, Bowen's disease (invasive type), and trichilemmal carcinoma, by immunohistochemical staining using a monoclonal antibody specific for E-cadherin. Similar to the E-cadherin expression in normal epidermis, E-cadherin was strongly expressed in all samples of BCC on the cell borders, whereas marked decrease or loss of E-cadherin expression was found in the tumor cells of SCC, Paget's disease, and Bowen's disease (invasive type). On the other hand, E-cadherin expression of trichilemmal carcinoma was slightly reduced. Considering the clinical and histological features of these skin carcinoma, the reduction of E-cadherin expression is considered to be associated with the invasion and metastasis of human skin carcinoma.
Tada
H
H
Department of Dermatology, Nara Medical University, Kashihara, Japan.
Hatoko
M
M
Muramatsu
T
T
Shirai
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001913:Bowen's Disease / Q000276:immunology / Q000473:pathology*; D015820:Cadherins / Q000032:analysis* / Q000378:metabolism; D002280:Basal Cell Carcinoma / Q000276:immunology / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D005455:Fluorescent Antibody Technique; D006197:Hair / Q000276:immunology / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000276:immunology / Q000473:pathology*; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology*
D015820:Cadherins