title: Preparation of pentofuranoside derivatives having ethynylene group and their reactions with oligodeoxyribonucleotides.
abstract: Furanoside derivatives having ethynylene group and related compounds were prepared. The reaction of these functionalized furanosides with oligodeoxy-ribonucleotide (21 mer, 5'-32P-GATAAGCTTGAAT TCATGGCC-3') and subsequent treatment with piperidine resulted in cleavage of the oligonucleotide.
authors.affiliation: Department of Chemisty, College of Science and Engineering, Aoyama Gakuin University, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sakagami
authors.forename: H
authors.initials: H
authors.lastname: Yamaga
authors.forename: A
authors.initials: A
authors.lastname: Ogawa
authors.forename: M
authors.initials: M
authors.lastname: Michida
authors.forename: O
authors.initials: O
authors.lastname: Mitsunobu
mesh_terms: D001483:Base Sequence; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D015394:Molecular Structure; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D010429:Pentoses / Q000138:chemical synthesis* / Q000737:chemistry; D010880:Piperidines
chemical_list: D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D010429:Pentoses; D010880:Piperidines; C032727:piperidine