title: Sequential combination of radio-chemotherapy (5-fluorouracil, cis-platinum and irradiation) in the management of locally advanced head and neck cancers.
abstract: Thirty-seven previously untreated patients with advanced, inoperable head and neck were treated with a sequential courses combining hypofractionated irradiation with chemotherapy (5-fluorouracil and cis-platinum). Each course was repeated every 4 weeks. Tumor response was evaluated and for 15 patients (41%) with a partial or complete regression after 3 radio-chemotherapy courses conventional radiotherapy was added. Eleven percent of all patients were in complete remission at the end of a treatment. This tumor response rate and the 50% rate of pain subside after first course for symptomatic patients contributed for a good palliative effect in the present study. However, the median survival of 7.2 months was considered unsatisfactory.
authors.affiliation: Centre of Oncology, M. Skłodowska-Curie Memorial Institute, Głiwice, Poland.
authors.forename: R
authors.initials: R
authors.lastname: Suwiński
authors.forename: B
authors.initials: B
authors.lastname: Pilecki
authors.forename: K
authors.initials: K
authors.lastname: Składowski
authors.forename: J
authors.initials: J
authors.lastname: Swiatnicka
authors.forename: A
authors.initials: A
authors.lastname: Zajusz
authors.forename: W
authors.initials: W
authors.lastname: Przeorek
authors.forename: B
authors.initials: B
authors.lastname: Utracka-Hutka
authors.forename: G
authors.initials: G
authors.lastname: Jakus
authors.forename: B
authors.initials: B
authors.lastname: Lange
authors.forename: D
authors.initials: D
authors.lastname: Lange
authors.forename: R
authors.initials: R
authors.lastname: Tarnawski
authors.forename: B
authors.initials: B
authors.lastname: Maciejewski
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D010865:Pilot Projects; D011878:Radiotherapy / Q000009:adverse effects
chemical_list: D002945:Cisplatin; D005472:Fluorouracil