title: Molecular cloning of the N-terminus of GTBP.
abstract: Defects in mismatch repair genes cause the genetic instability characteristic of hereditary nonpolyposis colorectal cancer and a subset of sporadic colon tumors. The newest member of the mismatch repair gene family, GTBP, has recently been identified as a partial cDNA. Here, we describe the isolation of its 5' terminus, allowing definition of the entire coding region. Several polymorphisms within the 5' end were identified and are presented.
authors.affiliation: Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA.
authors.forename: N C
authors.initials: NC
authors.lastname: Nicolaides
authors.forename: F
authors.initials: F
authors.lastname: Palombo
authors.forename: K W
authors.initials: KW
authors.lastname: Kinzler
authors.forename: B
authors.initials: B
authors.lastname: Vogelstein
authors.forename: J
authors.initials: J
authors.lastname: Jiricny
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA; D004268:DNA-Binding Proteins / Q000235:genetics*; D006367:HeLa Cells; D006801:Humans; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic
chemical_list: D004268:DNA-Binding Proteins; C094443:G-T mismatch-binding protein; D004247:DNA