Relationship of ventricular tachycardia to sleep/wakefulness in a model of sudden cardiac death.
Death from some childhood disorders such as sudden infant death syndrome and the congenital long QT syndrome are associated with specific behaviors such as sleep or emotional stress. We studied young German shepherd dogs that die suddenly during presumed sleep. These dogs have inherited ventricular tachycardia (VT) which is most frequent during sinus bradycardia and sinus arrhythmia. We hypothesized that the number of VT complexes (three or more consecutive ectopic complexes) would be greatest during sleep. Moreover, we hypothesized that pauses in the sinus rhythm of greater than 1000 ms would be greatest in the behavior with the most frequent VT. Behavioral states [excited, ambulatory, sitting, lying, rapid eye movement (REM) sleep] were quantified from 24-h video recordings of seven dogs. VT and pauses were quantified for each behavior using simultaneously recorded ECGs. A multivariate model was used to analyze the results. After controlling for time of day, lying, and REM sleep were significantly (p < 0.02) associated with VT, whereas more active behaviors were not. Time of day also independently affected the number of VT complexes. However, behavior and time of day did not account for all of the variability in the number of VT complexes. Pauses were significantly associated with behavior, with the highest number of pauses occurring during lying and REM sleep. However, pauses were not always associated with VT, indicating that a pause was a necessary, but not sufficient, condition for the development of VT. These results suggest that modulation of VT incidence in these animals is multifactorial and that the highest number of VT complexes is associated with the bradycardia that accompanies REM sleep.
Moïse
N S
NS
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA.
Brittain
D D
DD
Flahive
W J
WJ
Riccio
M L
ML
Ernst
R S
RS
Scarlett
J
J
Mohammed
H O
HO
Morrison
A R
AR
Gilmour
R F
RF
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D004195:Disease Models, Animal; D004285:Dogs; D004562:Electrocardiography; D012890:Sleep / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology; D017180:Tachycardia, Ventricular / Q000150:complications / Q000503:physiopathology*; D014743:Videotape Recording; D014851:Wakefulness / Q000502:physiology*