title: Molecular modeling of singlet-oxygen binding to anthraquinones in relation to the peroxidating activity of antitumor anthraquinone drugs.
abstract: Anthraquinone derivatives are important anti-cancer drugs possessing, however, undesirable peroxidating and, in consequence, cardiotoxic properties. This results from the mediation by these compounds of the one-electron reduction processes of the oxygen molecule, which produces the highly toxic superoxide anion radical and other active oxygen species. This article summarizes the results of our studies on the molecular aspects of the mechanism of anthraquinone-mediated peroxidation which were carried out using enzymatic-assay, electrochemical, and quantum-mechanical methods.
authors.affiliation: Department of Chemistry, University of Gdańsk, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Liwo
authors.forename: D
authors.initials: D
authors.lastname: Jeziorek
authors.forename: T
authors.initials: T
authors.lastname: Ossowski
authors.forename: D
authors.initials: D
authors.lastname: Dyl
authors.forename: A
authors.initials: A
authors.lastname: Tempczyk
authors.forename: J
authors.initials: J
authors.lastname: Tarasiuk
authors.forename: M
authors.initials: M
authors.lastname: Nowacka
authors.forename: E
authors.initials: E
authors.lastname: Borowski
authors.forename: W
authors.initials: W
authors.lastname: Woźnicki
mesh_terms: D000880:Anthraquinones / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry*; D004583:Electrons; D010100:Oxygen / Q000737:chemistry*; D010545:Peroxides / Q000737:chemistry*; D026082:Singlet Oxygen
chemical_list: D000880:Anthraquinones; D000970:Antineoplastic Agents; D010545:Peroxides; D026082:Singlet Oxygen; D010100:Oxygen