title: bli-4, a gene that is rapidly induced by blue light, encodes a novel mitochondrial, short-chain alcohol dehydrogenase-like protein in Neurospora crassa.
abstract: Blue light plays an important role in developmental control throughout nature. The bli-4 gene of Neurospora crassa, together with bli-3, al-1 and al-2, is rapidly inducible by blue light. Induction leads to a ninety-fold increase in transcription rate over the dark control level, and the gene therefore appears to be of prime importance in the blue-light induction pathway of N. crassa. We describe the sequencing and analysis of bli-4 and the 38 kDa protein it encodes. We show that the protein is very rapidly imported into the mitochondria and exhibits high homology with the family of short-chain alcohol dehydrogenases.
authors.affiliation: Max-Planck-Institut für molekulare Genetik, Berlin, Germany.
authors.forename: J J
authors.initials: JJ
authors.lastname: Bruchez
authors.forename: J
authors.initials: J
authors.lastname: Eberle
authors.forename: W
authors.initials: W
authors.lastname: Kohler
authors.forename: V
authors.initials: V
authors.lastname: Kruft
authors.forename: A
authors.initials: A
authors.lastname: Radford
authors.forename: V E
authors.initials: VE
authors.lastname: Russo
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D004271:DNA, Fungal; D005656:Fungal Proteins / Q000235:genetics*; D005800:Genes, Fungal; D008027:Light; D008969:Molecular Sequence Data; D009492:Neurospora crassa / Q000201:enzymology* / Q000235:genetics
chemical_list: D004271:DNA, Fungal; D005656:Fungal Proteins; D000426:Alcohol Dehydrogenase; C101838:Bli-4 protein, Neurospora