title: Reliability of carnitine concentrations measured in single postprandial urine samples from dogs.
abstract: OBJECTIVE
  To evaluate the reliability of urine carnitine concentrations measured in single postprandial samples, compared with carnitine concentrations measured in 24-hour urine samples.
  
  
  METHODS
  19 healthy Beagles.
  
  
  METHODS
  After emptying the urinary bladder by catheterization, dogs were fed a canned canine maintenance diet. Approximately 8 hours later, urine, plasma, and serum samples were obtained for determination of urinary carnitine fractional excretion and urine carnitine-to-creatinine concentration ratio. Results were compared with 24-hour urinary carnitine excretion rate.
  
  
  RESULTS
  Fractional excretion of carnitine and urine carnitine-to-creatinine ratios correlated poorly with 24-hour urinary carnitine excretion.
  
  
  CONCLUSIONS
  Determination of 24-hour urinary carnitine excretion is recommended to measure urine carnitine concentrations in dogs.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA.
authors.forename: S
authors.initials: S
authors.lastname: Sanderson
authors.forename: C
authors.initials: C
authors.lastname: Osborne
authors.forename: J
authors.initials: J
authors.lastname: Lulich
authors.forename: M E
authors.initials: ME
authors.lastname: Pierpont
authors.forename: K
authors.initials: K
authors.lastname: Gross
authors.forename: P
authors.initials: P
authors.lastname: Ogburn
authors.forename: L
authors.initials: L
authors.lastname: Koehler
authors.forename: M
authors.initials: M
authors.lastname: Carvalho
mesh_terms: D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002331:Carnitine / Q000097:blood / Q000652:urine*; D004285:Dogs; D005260:Female; D008297:Male; D009919:Orchiectomy; D010052:Ovariectomy; D019518:Postprandial Period; D012016:Reference Values; D015203:Reproducibility of Results
chemical_list: D015415:Biomarkers; D002331:Carnitine