title: SSCP analysis of the tyrosine kinase domain of the insulin receptor gene: polymorphisms detected in South African black and white subjects.
abstract: The frequency of DNA polymorphisms in the tyrosine kinase domain (exons 17-21) of the insulin receptor gene was assessed in 30 black and 30 white South Africans, using single-stranded conformation polymorphism and direct sequencing analysis. A comparison of the frequencies of the normal versus the combined polymorphic alleles, found only in exon 17, showed a significant difference between black and white groups (P = 0.037).
authors.affiliation: Department of Medicine, University of the Witwatersrand Medical School, Johannesburg, South Africa.
authors.forename: V R
authors.initials: VR
authors.lastname: Panz
authors.forename: P
authors.initials: P
authors.lastname: Ruff
authors.forename: B I
authors.initials: BI
authors.lastname: Joffe
authors.forename: M A
authors.initials: MA
authors.lastname: Kedda
authors.forename: H C
authors.initials: HC
authors.lastname: Seftel
mesh_terms: D000328:Adult; D001483:Base Sequence; D044383:Black People / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D018807:Polymorphism, Single-Stranded Conformational; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D011972:Receptor, Insulin / Q000235:genetics*; D013019:South Africa; D044465:White People / Q000235:genetics*
chemical_list: D011505:Protein-Tyrosine Kinases; D011972:Receptor, Insulin