Mechanisms of acute and chronic nephrotoxicity from immunosuppressive drugs.
Cyclosporine and related compounds have dramatically improved the short-term success of solid organ transplantation. This paper outlines the pathophysiologic mechanisms of the nephrotoxicity of these compounds, highlighting relevant clinical and experimental work. It is hoped that as further understanding of these mechanisms evolves, rational therapeutic strategies will be available.
Bennett
W M
WM
Division of Nephrology, Hypertension, and Clinical Pharmacology, Oregon Health Sciences University, Portland, USA.
D000818:Animals; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D007668:Kidney / Q000187:drug effects*; D007674:Kidney Diseases / Q000139:chemically induced*; D016030:Kidney Transplantation / Q000276:immunology
D007166:Immunosuppressive Agents