title: Novel strategies for treatment-resistant depression.
abstract: This article describes a highly selective constellation of the more unique strategies for managing the treatment-resistant patient. In light of the often-devastating toll that treatment-resistant depression takes on an individual's life, it behooves us to continue the search for more effective strategies for those patients that fail more traditional interventions. As each successive move down the treatment algorithm flowchart becomes necessary, the risk/benefit ratio may shift toward less well-substantiated, but still biologically informed, strategies. Although some of the more unusual treatments described in this article represent minimally charted territories, the more promising techniques are deserving of further careful exploration.
authors.affiliation: Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia, USA.
authors.forename: M
authors.initials: M
authors.lastname: Hornig-Rohan
authors.forename: O M
authors.initials: OM
authors.lastname: Wolkowitz
authors.forename: J D
authors.initials: JD
authors.lastname: Amsterdam
mesh_terms: D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D019090:Case Management; D017024:Chemotherapy, Adjuvant; D003657:Decision Making; D003866:Depressive Disorder / Q000188:drug therapy* / Q000628:therapy; D004347:Drug Interactions; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D006179:Gyrus Cinguli / Q000601:surgery; D006801:Humans; D010789:Phototherapy; D011619:Psychotropic Drugs / Q000009:adverse effects / Q000627:therapeutic use; D012892:Sleep Deprivation
chemical_list: D000928:Antidepressive Agents; D011619:Psychotropic Drugs