[Scavenger receptor gene--regulation of scavenger receptor gene expression in alveolar macrophages and the pathogenesis of pulmonary alveolar proteinosis].
It was previously reported, that scavenger receptors expressed on the surface membrane of human alveolar macrophages, mediated endocytosis of a diverse group of negatively charged macromolecules. Moreover, it was reported that scavenger receptors might contribute to host-defense function and it was also reported that the expression of scavenger receptors was suppressed by some cytokines, interferon-gamma, tumor necrosis factor-alpha, and transforming growth factor-beta 1. In our previous study, we suggested that one of the pathogenesises of pulmonary alveolar proteinosis may be involved in the suppressed expression of scavenger receptors by TGF-beta 1. In this paper, the regulation of scavenger receptor gene expressions is summarized and further we refer to the pathogenesis of pulmonary alveolar proteinosis.
Mori
T
T
First Department of Internal Medicine, Kumamoto University School of Medicine.
Suga
M
M
D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D008565:Membrane Proteins; D051379:Mice; D011649:Pulmonary Alveolar Proteinosis / Q000209:etiology*; D011650:Pulmonary Alveoli / Q000276:immunology*; D011971:Receptors, Immunologic / Q000235:genetics*; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B
D008565:Membrane Proteins; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; C454739:Scarb1 protein, mouse; D051122:Scavenger Receptors, Class B