Lanthanide or transition metal ions-mediated cleavage of DNA by hydroxamic acid derivative.
N-[5-(hydroxylaminocarbonyl)pentyl]phenanthridium chloride 1 has been shown to induce cleavage of ColE1 DNA in the presence of transition (ferrous, ferric and vanadyl) or lanthanide(III) (lutetium, thulium and europium) metal ions. The addition of free radical scavengers inhibits the former reaction, but does not the latter case.
Hashimoto
S
S
Department of Biological Science and Technology, Science University of Tokyo, Chiba, Japan.
Nakamura
Y
Y
D004269:DNA, Bacterial / Q000737:chemistry* / Q000302:isolation & purification; D004587:Electrophoresis, Agar Gel; D016166:Free Radical Scavengers; D006877:Hydroxamic Acids; D008670:Metals; D008674:Metals, Rare Earth; D015394:Molecular Structure; D010957:Plasmids / Q000737:chemistry / Q000302:isolation & purification; D017382:Reactive Oxygen Species
D004269:DNA, Bacterial; D016166:Free Radical Scavengers; D006877:Hydroxamic Acids; D008670:Metals; D008674:Metals, Rare Earth; D017382:Reactive Oxygen Species