title: A molecular model for human Big-Endothelin-1 (Big ET-1).
abstract: A molecular model has been developed for human Big Endothelin-1, which is the immediate precursor to the potent vasoconstrictor polypeptide endothelin-1 and the target of the highly specific endothelin converting enzyme. This model is produced by a threading algorithm protocol and is consistent with all the currently available structural and biochemical data for this molecule.
authors.affiliation: Department of Crystallography, Birkbeck College, University of London, UK.
authors.forename: H
authors.initials: H
authors.lastname: Peto
authors.forename: R
authors.initials: R
authors.lastname: Corder
authors.forename: R W
authors.initials: RW
authors.lastname: Janes
authors.forename: B A
authors.initials: BA
authors.lastname: Wallace
mesh_terms: D000465:Algorithms; D004220:Disulfides / Q000737:chemistry; D010450:Endopeptidases / Q000378:metabolism; D019332:Endothelin-1 / Q000494:pharmacology; D016232:Endothelins / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D011498:Protein Precursors / Q000737:chemistry*; D017433:Protein Structure, Secondary
chemical_list: D004220:Disulfides; D019332:Endothelin-1; D016232:Endothelins; D011498:Protein Precursors; D010450:Endopeptidases