[Clinical treatment with cisplatin (CDDP) in pleural cavity for carcinomatous pleurisy--study of intraarterial concentration].
We investigated the intraarterial concentration of CDDP following continuous hyperthermic pleural perfusion (CHPP, 43 degrees C for 30 to 60 minutes) with 100 mg CDDP diluted in distilled water or saline in 6 lung cancers (2 pleural dissemination, 1 malignant pleural effusion, 3 positive wash cytology), 2 metastatic lung cancer (from breast cancer, 1 rhabdomyosarcoma with pleural dissemination), and 1 metastatic pleural tumor (adenocarcinoma, unknown origin). The level of CDDP was 9.16 to 24.1 micrograms/ml (average 16.1) in perfusion fluid, 0.3 after 5 minutes, 0.41 to 0.85 after 60 minutes and 0.15 to 0.27 (average 0.22) after 24 hours. There were no severe side effects nor any difference in effects by dilution fluid between distilled water and saline. Only 1 patient suffered pleural effusion after this treatment. The results suggested that CHPP with CDDP diluted by saline was effective for prevention and treatment of pleural dissemination.
Hara
S
S
First Dept. of Surgery, Nagasaki University School of Medicine.
Tagawa
Y
Y
Tsuji
H
H
Oka
T
T
Morinaga
M
M
Shingu
H
H
Nagayasu
T
T
Ikuta
Y
Y
Ayabe
H
H
D000368:Aged; D002945:Cisplatin / Q000008:administration & dosage* / Q000097:blood; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010477:Perfusion / Q000379:methods; D010994:Pleura; D016066:Pleural Effusion, Malignant / Q000097:blood / Q000188:drug therapy*; D010997:Pleural Neoplasms / Q000097:blood / Q000188:drug therapy / Q000556:secondary
D002945:Cisplatin