title: No effect of a very low dose of n-3 fatty acids on monocyte function in healthy humans.
abstract: There is some evidence that intake of sea food rich in n-3 polyunsaturated fatty acids (PUFA) may protect against coronary heart disease (CHD). Thus, even very low daily amounts of n-3 PUFA below 0.5 g have been reported to reduce the incidence of CHD, although it is unknown by what mechanisms this may occur. Monocytes are of major importance in atherogenesis, and we therefore studied the effect of a daily supplement with 0.65 g of n-3 PUFA for 12 weeks on monocyte function in a randomized placebo-controlled trial of 32 healthy subjects. No effect of dietary n-3 PUFA could be demonstrated on monocyte chemotaxis, on chemiluminescence, or on formation of cytokines and leukotriene B4 from activated monocytes.
authors.affiliation: Department of Medicine, Aalborg Hospital, Copenhagen, Denmark.
authors.forename: E B
authors.initials: EB
authors.lastname: Schmidt
authors.forename: K
authors.initials: K
authors.lastname: Varming
authors.forename: J M
authors.initials: JM
authors.lastname: Møller
authors.forename: I
authors.initials: I
authors.lastname: Bülow Pedersen
authors.forename: P
authors.initials: P
authors.lastname: Madsen
authors.forename: J
authors.initials: J
authors.lastname: Dyerberg
mesh_terms: D000328:Adult; D002633:Chemotaxis; D016207:Cytokines / Q000096:biosynthesis; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000494:pharmacology; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D006801:Humans; D007975:Leukotriene B4 / Q000096:biosynthesis; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects / Q000502:physiology*; D010919:Placebos
chemical_list: D016207:Cytokines; D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3; D010919:Placebos; D007975:Leukotriene B4