Anti-tumor-promoting activities of triterpenoids from ferns. I.
To search for possible anti-tumor-promoters (cancer chemopreventive agents), we carried out primary screening of 23 triterpenoid hydrocarbons (1-23) isolated from ferns using an in vitro synergistic assay system. Of these triterpenoids, hop-17(21)-ene (2), neohop-13(18)-ene (3), neohop-12-ene (4), taraxerane (17), multiflor-9(11)-ene (18), multiflor-8-ene (19), glutin-5(10)-ene (21) and taraxastane (23) exhibited remarkable inhibitory effects on Epstein-Barr virus (EBV) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). Further, compounds 2 and 3 exhibited remarkable anti-tumorpromoting effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test using 7,12-dimethybenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.
Konoshima
T
T
Kyoto Pharmaceutical University, Japan.
Takasaki
M
M
Tokuda
H
H
Masuda
K
K
Arai
Y
Y
Shiojima
K
K
Ageta
H
H
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D004854:Herpesvirus 4, Human; D051379:Mice; D008813:Mice, Inbred ICR; D010212:Papilloma / Q000473:pathology; D010946:Plants, Medicinal / Q000737:chemistry*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D016588:Anticarcinogenic Agents; D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes