title: Preoperative morbidity and anaesthesia-related negative events in patients undergoing conventional or laparoscopic cholecystectomy.
abstract: Laparoscopic cholecystectomy is the standard method for surgical treatment of non-malignant gall bladder disease. Well tolerated in otherwise healthy patients, it remains however, questionable whether the laparoscopic procedure in patients with severe pre-existing morbidity is associated with a higher incidence of negative intraoperative events than open cholecystectomy. Therefore, the incidence of negative intraoperative events was prospectively investigated in a series of 1,367 patients (319 with open cholecystectomy and 1,048 with laparoscopic cholecystectomy) who were analysed for occurrence of events such as hypertension, hypotension, arrhythmia, unusual bleeding and transfusion requirement, regurgitation or aspiration of gastric content and respiratory disorders. For further analysis the patients undergoing each operative procedure were divided into two subgroups with either preoperative ASA physical status I and II or III and IV. The study groups were comparable in sex and age. There were no intraoperative deaths. The frequency of hypertension, hypotension or arrhythmia alone and in combination was similar in both groups. The need for intervention was significantly more frequent in ASA class I/II patients with laparoscopic cholecystectomy. Respiratory disorders were rare. There was a significantly higher incidence of postoperative ventilatory support in patients with conventional cholecystectomy. Transfusion was required significantly less often in patients with laparoscopic cholecystectomy (0.19% versus 15.36%). CO2-pneumoperitoneum led to severe circulatory alterations in 7 healthy patients. The most severe negative event was a cardiac arrest in 1 female patient who was successfully resuscitated without any sequelae. In ASA-class III and IV patients intraoperative negative events were equally frequent and independent of the procedure. Severe preoperative morbidity per se seems to be no contraindication for laparoscopic cholecystectomy.
authors.affiliation: Department of Anaesthesia, Merheim Hospital, Clinics of Cologne, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Stuttmann
authors.forename: A
authors.initials: A
authors.lastname: Paul
authors.forename: M
authors.initials: M
authors.lastname: Kirschnik
authors.forename: M
authors.initials: M
authors.lastname: Jahn
authors.forename: M
authors.initials: M
authors.lastname: Doehn
mesh_terms: D000328:Adult; D000368:Aged; D000768:Anesthesia, General / Q000009:adverse effects; D001145:Arrhythmias, Cardiac / Q000209:etiology; D016063:Blood Loss, Surgical; D001803:Blood Transfusion; D002245:Carbon Dioxide / Q000008:administration & dosage / Q000009:adverse effects; D002763:Cholecystectomy / Q000009:adverse effects; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects; D000075202:Contraindications; D004194:Disease; D005260:Female; D005705:Gallbladder Diseases / Q000601:surgery; D006304:Health Status; D006323:Heart Arrest / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007022:Hypotension / Q000209:etiology; D015994:Incidence; D007431:Intraoperative Complications; D008297:Male; D008875:Middle Aged; D011015:Pneumonia, Aspiration / Q000209:etiology; D011028:Pneumoperitoneum, Artificial / Q000009:adverse effects; D011446:Prospective Studies; D012121:Respiration, Artificial; D012140:Respiratory Tract Diseases / Q000209:etiology; D014839:Vomiting / Q000209:etiology
chemical_list: D002245:Carbon Dioxide