Probable risk of tumour induction after retro-orbital irradiation for Graves' ophthalmopathy.
Retrobulbar irradiation for Graves' ophthalmopathy is considered as a safe treatment and has recently been recommended as the initial treatment for patients with moderately severe eye problems. However, calculations using risk factors presently known reveal a theoretical risk of radiation-induced cancer of 1.2%. Therefore, the authors suggest that this treatment should be reserved for the elderly patient, for example above the age of 40-50 years.
Snijders-Keilholz
A
A
Department of Clinical Oncology, University Hospital Leiden, Netherlands.
De Keizer
R J
RJ
Goslings
B M
BM
Van Dam
E W
EW
Jansen
J T
JT
Broerse
J J
JJ
D000328:Adult; D000367:Age Factors; D005128:Eye Diseases / Q000532:radiotherapy*; D005260:Female; D006111:Graves Disease / Q000532:radiotherapy*; D006801:Humans; D009010:Monte Carlo Method; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D019047:Phantoms, Imaging; D011336:Probability; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy / Q000009:adverse effects; D012307:Risk Factors; D012449:Safety