title: The influence of calcium infusion on serum prolactin in hyperprolactinemic women.
abstract: This study investigated the influence of calcium on serum prolactin (PRL) in hyperprolactinemic and healthy women. Previous studies have shown an inhibitory effect of Ca2+ on serum PRL, related to the degree of hypercalcemia. Serum PRL levels were measured by immunoradiometric assay (IRMA) in subjects before and one hour after 1375 mg Ca2+ injection. Serum PRL level was significantly decreased by calcium injection in hyperprolactinemic women (89.2 +/- 29.1 and 63.3 +/- 35.8 ng/ml; p < 0.01) while it was not significant (p > 0.05) in women with normal PRL levels (12.6 +/- 5.1 ng/ml and 11.3 +/- 4.0 ng/ml). These results indicate that acute alterations in serum calcium levels affect PRL secretion in hyperprolactinemic women.
authors.affiliation: Department of Biochemistry, Atatürk University, Turkey.
authors.forename: L
authors.initials: L
authors.lastname: Yildiz
authors.forename: B S
authors.initials: BS
authors.lastname: Uyanik
authors.forename: S
authors.initials: S
authors.lastname: Kuşkay
authors.forename: M
authors.initials: M
authors.lastname: Küçük
mesh_terms: D000328:Adult; D002118:Calcium / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000188:drug therapy*; D015592:Immunoradiometric Assay; D011388:Prolactin / Q000097:blood*
chemical_list: D011388:Prolactin; D002118:Calcium