title: Structure and stability of DNA containing alpha-deoxyadenosine.
abstract: The alpha-anomer of 2'-deoxyadenosine (alpha) is a major adenine lesion produced by hydroxyl radicals. This lesion was specifically incorporated in duplexes d(TGAGXGTAC).d(GTACNCTCA), where X = alpha and N = A, G, C, or T. The thermodynamic and structural perturbations introduced into DNA by alpha were assessed by UV-melting measurements and molecular mechanics calculations.
authors.affiliation: Department of Polymer Science and Engineering, Kyoto Institute of Technology, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ide
authors.forename: H
authors.initials: H
authors.lastname: Ikeda
authors.forename: K
authors.initials: K
authors.lastname: Makino
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: N
authors.initials: N
authors.lastname: Sugimoto
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000528:radiation effects; D003839:Deoxyadenosines / Q000737:chemistry*; D004355:Drug Stability; D017665:Hydroxyl Radical; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry / Q000528:radiation effects; D013816:Thermodynamics; D014466:Ultraviolet Rays
chemical_list: D003839:Deoxyadenosines; D009838:Oligodeoxyribonucleotides; D017665:Hydroxyl Radical; D004247:DNA