Field trial of inactivated oral cholera vaccines in Bangladesh: results from 5 years of follow-up.
To determine the protective efficacy (PE) of three doses of oral B subunit-killed whole cell (BS-WC) or killed whole cell-only (WC) vaccines against cholera, a clinical trial was conducted among 62285 children over 2 years and adult women in rural Bangladesh. During 5 years of follow-up, there were 144 cases of cholera in the BS-WC group (PE = 49%; P < 0.001), 150 in the WC group (PE = 47%; P < 0.001), and 283 in the K12 group. Protection by each vaccine was evident only during the first three years of follow-up; long-term protection of young children was observed only against classical but not El Tor cholera; 3-year protection against both cholera biotypes occurred among older persons, but at a higher level against classical cholera.
van Loon
F P
FP
International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Clemens
J D
JD
Chakraborty
J
J
Rao
M R
MR
Kay
B A
BA
Sack
D A
DA
Yunus
M
M
Ali
M
M
Svennerholm
A M
AM
Holmgren
J
J
D000284:Administration, Oral; D000328:Adult; D000367:Age Factors; D001459:Bangladesh / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D002771:Cholera / Q000453:epidemiology / Q000517:prevention & control*; D022121:Cholera Vaccines / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D015164:Vaccines, Inactivated / Q000627:therapeutic use
D022121:Cholera Vaccines; D015164:Vaccines, Inactivated