Caries-related salivary microorganisms and salivary flow rate in bone marrow recipients.
Cancer treatments often induce oral complications. In this study we investigate longitudinally the salivary gland function, the salivary caries-related microorganisms, and buffer capacity in bone marrow recipients. Stimulated saliva samples were taken midmorning. The salivary factors were studied in 42 patients from before transplant until 4 months after transplant. A dramatic reduction (66%) of salivary flow rate is noticed in all patients at 1 month after transplant, and only a partial recovery (42% reduction) is seen after 4 months. A clear shift toward a lower buffer capacity and a higher amount of cariogenic microorganisms is seen posttransplant. This shift is more pronounced when total body irradiation was included in the pretransplant conditioning therapy. These findings indicate that the studied parameters in transplant recipients can contribute to a higher caries risk and oral complications during the early posttransplant period.
Dens
F
F
Department of Conservative Dentistry, Free University of Brussels, Belgium.
Boogaerts
M
M
Boute
P
P
Declerck
D
D
Demuynck
H
H
Vinckier
F
F
Belgium
B
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016465:Bone Marrow Purging / Q000009:adverse effects; D016026:Bone Marrow Transplantation; D002021:Buffers; D015169:Colony Count, Microbial; D003731:Dental Caries / Q000382:microbiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007778:Lactobacillus / Q000302:isolation & purification*; D007938:Leukemia / Q000628:therapy; D008137:Longitudinal Studies; D008223:Lymphoma / Q000628:therapy; D008875:Middle Aged; D009059:Mouth Diseases / Q000209:etiology; D012307:Risk Factors; D012463:Saliva / Q000187:drug effects / Q000378:metabolism* / Q000382:microbiology* / Q000528:radiation effects; D012469:Salivary Glands / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D012636:Secretory Rate; D013295:Streptococcus mutans / Q000302:isolation & purification*; D014916:Whole-Body Irradiation / Q000009:adverse effects
D002021:Buffers; D007166:Immunosuppressive Agents