Hepatitis B virus-induced hepatocellular carcinoma: possible roles for HBx.
The hepatitis B virus-encoded protein, HBx, may contribute to carcinogenesis by perturbing cell growth and differentiation. There is some evidence indicating that HBx represses the nuclear import of the tumour repressor p53 and p53-dependent trans-activation and that HBx activates members of the basic region-leucine zipper (bZIP) family.
Cromlish
J A
JA
Dept of Biochemistry, McGill University, Montreal, Quebec, Canada. cromlish@medcor.mcgill.ca
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000821:virology*; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D005814:Genes, Viral; D006511:Hepatitis B Antigens / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D006801:Humans; D016350:Leucine Zippers / Q000502:physiology; D008113:Liver Neoplasms / Q000821:virology*; D051379:Mice; D008822:Mice, Transgenic; D016328:NF-kappa B / Q000378:metabolism; D015534:Trans-Activators / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D054334:Viral Regulatory and Accessory Proteins
D017362:Cyclic AMP Response Element-Binding Protein; D006511:Hepatitis B Antigens; D016328:NF-kappa B; D015534:Trans-Activators; D016159:Tumor Suppressor Protein p53; D054334:Viral Regulatory and Accessory Proteins; C057628:hepatitis B virus X protein