Urticaria from allergy to a purified human anti-Rh antibody preparation.
This case presentation describes a young woman who developed generalized urticaria after receiving the human anti-RhD(D) preparation, WinRho, intravenously. Allergy skin tests and the radioallergosorbent test (RAST) for IgE antibodies to the human anti-D immunoglobulin preparation were positive. Further studies using high-pressure liquid chromatography and protein A column chromatography implicated a nonimmunoglobulin low-molecular-weight contaminant. This case report illustrates an allergic reaction to a highly purified human immunoglobulin preparation, and demonstrates approaches to assessment of such a reaction.
Sulakvelidze
I
I
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
Evans
S
S
Switzer
I
I
Underdown
B
B
Greenbaum
J
J
Dolovich
J
J
D000328:Adult; D002170:Canada; D004340:Drug Contamination; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007518:Isoantibodies / Q000009:adverse effects* / Q000276:immunology; D011852:Radioallergosorbent Test; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin / Q000009:adverse effects* / Q000276:immunology; D012882:Skin Tests; D014581:Urticaria / Q000209:etiology*
D007518:Isoantibodies; C033242:RH-antibodies; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin; D007073:Immunoglobulin E