Transient expression of CD20 antigen (pan B cell marker) in activated lymph node T cells.
In contrast to the case of peripheral T cells, the surface expression of CD20 antigen and the expression of CD20 mRNA in monkey lymph node (LN) T cells underwent a noticeable increase when they were cultured with mitogen and interleukin-2 (IL-2). To confirm in vivo regulation of CD20 expression during the activation of LN T cells, we examined LNs derived from monkeys experimentally inoculated with simian immunodeficiency virus (SIV). Significant expression of CD20 antigen was detected in the T cells of the LNs at the stage of lymphadenopathy. These findings suggest that lymphocyte activation in the LNs induced expression of the CD20 molecule in some T cells.
Murayama
Y
Y
Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan.
Mukai
R
R
Sata
T
T
Matsunaga
S
S
Noguchi
A
A
Yoshikawa
Y
Y
D000818:Animals; D015703:Antigens, CD / Q000032:analysis; D018951:Antigens, CD20 / Q000235:genetics / Q000276:immunology*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D002478:Cells, Cultured; D037181:Lectins, C-Type; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000276:immunology; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D008213:Lymphocyte Activation; D008253:Macaca mulatta; D012333:RNA, Messenger; D016097:Simian Acquired Immunodeficiency Syndrome / Q000097:blood / Q000276:immunology; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000821:virology; D000099192:CD69 Antigens
D015703:Antigens, CD; D018951:Antigens, CD20; D000945:Antigens, Differentiation, T-Lymphocyte; D037181:Lectins, C-Type; D012333:RNA, Messenger; D000099192:CD69 Antigens