title: Comparative use of muscle relaxants and their reversal in three European countries: a survey in France, Germany and Great Britain.
abstract: A survey was conducted among British, French and German anaesthetists to evaluate possible national differences in the peri-operative use of muscle relaxants and their reversal agents. The same non-depolarizing relaxants are used in all three countries, with the exception of d-tubocurarine, which is only available in Great Britain, and alcuronium which is mainly used in Germany. The French anaesthetists seem to use significantly less succinylcholine than their peers in Great Britain or Germany for both elective and emergency intubation. Monitoring of neuromuscular blockade still relies mainly on "clinical judgement'. Reversal of non-depolarizing muscle relaxants is performed routinely in Great Britain, while a substantial number of French anaesthetists avoid the use of a reversal. Dose regimes for neostigmine vary largely, with German anaesthetists administering the lowest, and British anaesthetists administering the highest doses. Side effects of reversal agents are reported by colleagues from all three countries in too high a percentage to justify uncritical administration of these drugs. In Germany there seems to be a noteworthy lack of recovery facilities.
authors.affiliation: Department of Anaesthetics and Surgical Intensive Care, Justus-Liebig-University, Giessen, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Osmer
authors.forename: C
authors.initials: C
authors.lastname: Vogele
authors.forename: B
authors.initials: B
authors.lastname: Zickmann
authors.forename: G
authors.initials: G
authors.lastname: Hempelmann
mesh_terms: D000443:Alcuronium / Q000008:administration & dosage; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D004363:Drug Utilization; D005602:France; D005858:Germany; D006801:Humans; D007442:Intubation, Intratracheal; D008991:Monitoring, Physiologic; D009388:Neostigmine / Q000008:administration & dosage / Q000009:adverse effects; D019148:Neuromuscular Blockade; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D009467:Neuromuscular Depolarizing Agents / Q000008:administration & dosage; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage / Q000037:antagonists & inhibitors; D011997:Recovery Room; D013390:Succinylcholine / Q000008:administration & dosage; D014403:Tubocurarine / Q000008:administration & dosage; D006113:United Kingdom
chemical_list: D002800:Cholinesterase Inhibitors; D009466:Neuromuscular Blocking Agents; D009467:Neuromuscular Depolarizing Agents; D003473:Neuromuscular Nondepolarizing Agents; D009388:Neostigmine; D013390:Succinylcholine; D000443:Alcuronium; D014403:Tubocurarine