title: [Chronic active EB virus infection and granular lymphocytes proliferative disorders in Japan].
abstract: To clarify the characteristics of chronic active EB virus infection (CAEBV) in Japan, and to investigate the relation between granular lymphocytes proliferative disorder (GLPD) and EB virus, we conducted a survey through a questionnaire conducted throughout Japan. Among 17 registered patients with CAEBV, 9 developed various types of lymphoproliferative disorders (LPDs), and 6 patients died of LPD. Among 72 cases of GLPD, 43 were CD3-positive and 27 were CD3-negative. EB viral DNA was detected in the peripheral mononuclear cells in 6 of 7 CD3-negative and 1 of 4 CD3-positive cases. These data suggest that EB virus-associated LPDs frequently derive from patients with CAEBV. However, some GLPD patients without CAEBV, especially for CD3-negative GLPD, are associated with EB virus infection. Therefore detection of EB viral DNA is very important to understand the pathogenesis of GLPD.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Osaka University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ishihara
authors.forename: J
authors.initials: J
authors.lastname: Hara
authors.forename: A
authors.initials: A
authors.lastname: Tawa
authors.forename: K
authors.initials: K
authors.lastname: Kawa
mesh_terms: D000293:Adolescent; D000328:Adult; D017252:CD3 Complex / Q000032:analysis; D002908:Chronic Disease; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006566:Herpesviridae Infections / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011795:Surveys and Questionnaires; D014412:Tumor Virus Infections / Q000150:complications*
chemical_list: D017252:CD3 Complex; D004279:DNA, Viral