N(9)-Substituted 2-phenyl-N(6)-benzyl-8-azaadenines: A1 adenosine receptor affinity. A comparison with the corresponding N(6)-substituted 2-phenyl-N(9)-benzyl-8-azaadenines.
The synthesis and the assay of title compounds were accomplished. Biological results indicated the general lack of activity among the tested disubstituted compounds bearing the benzyl group on N(6) and confirmed the activity of those with this group on N(9).
Biagi
G
G
Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Italy.
Giorgi
I
I
Livi
O
O
Scartoni
V
V
D000225:Adenine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008566:Membranes / Q000187:drug effects / Q000378:metabolism; D058915:Purinergic P1 Receptor Antagonists; D012756:Sheep
D058915:Purinergic P1 Receptor Antagonists; D000225:Adenine