Studies on the carcinogenic and myocardial effects of 2-amino-3-methylimidazo [4,5-f] quinoline (IQ) in nonhuman primates.
The heterocyclic aromatic amine 2-amino-3-methylimidazo [4,5-f] quinoline (IQ) is one of three heterocyclic amine mutagens currently being evaluated for carcinogenic activity in nonhuman primates, primarily cynomolgus monkeys. IQ was administered by gavage five times a week at doses of 10 or 20 mg/kg. Thus far IQ induced tumors in 50 percent of the monkeys at the 10 mg/kg dose and in 85 percent of the monkeys at the 20 mg/kg dose. Because H and E sections of the myocardium from IQ-treated animals demonstrated inflammatory infiltrate and studies of IQ-DNA adducts in monkeys, by the 32P-postlabeling method, showed high levels of adducts in the heart a systematic study of cardiac pathologic changes associated with chronic administration of IQ was undertaken. Both light and electron microscopic abnormalities were seen. The possibility exists that heterocyclic aromatic amines may be etiologic factors for human cancer and myocardial disease.
Adamson
R H
RH
Division of Cancer Etiology, National Cancer Institute Bethesda, Maryland 20892-4255, USA.
Farb
A
A
Virmani
R
R
Snyderwine
E G
EG
Thorgeirsson
S S
SS
Takayama
S
S
Sugimura
T
T
Dalgard
D W
DW
Thorgeirsson
U P
UP
D000284:Administration, Oral; D000818:Animals; D002273:Carcinogens / Q000008:administration & dosage / Q000633:toxicity*; D003296:Cooking; D018736:DNA Adducts / Q000032:analysis; D005355:Fibrosis; D006321:Heart / Q000187:drug effects*; D006358:Hot Temperature; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000633:toxicity*; D007249:Inflammation; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology / Q000556:secondary; D008175:Lung Neoplasms / Q000139:chemically induced / Q000556:secondary; D008252:Macaca fascicularis; D008460:Meat; D009206:Myocardium / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D009336:Necrosis; D011804:Quinolines / Q000008:administration & dosage / Q000633:toxicity*; D011810:Quinoxalines / Q000633:toxicity*
D002273:Carcinogens; D018736:DNA Adducts; D007093:Imidazoles; D011804:Quinolines; D011810:Quinoxalines; C036990:2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; C049584:2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; C036989:2-amino-3,4-dimethylimidazo(4,5-f)quinoline