title: [Fibrinolytic and peripheral serotonergic system in patients with glomerulonephritis].
abstract: Some fibrinolytic parameters, whole blood and plasma serotonin were studied in normotensive and hypertensive patients with glomerulonephritis. Diminished activity of tissue plasminogen activator (tPA) and a significant prolongation of the euglobulin clot lysis time was observed in hypertensive and normotensive patients with glomerulonephritis when compared to healthy volunteers. Antigen and activity of inhibitor of tissue plasminogen activator (PAI) was found to be higher in hypertensive patients relative to control group. Whole blood serotonin was significantly lower, whereas plasma serotonin was higher in normotensive and hypertensive patients with glomerulonephritis when compared to healthy subjects. Impairment in fibrinolysis and elevated plasma serotonin levels may contribute to the increased risk of thromboembolic complications and accelerated atherosclerosis in these patients.
authors.affiliation: Z Kliniki Nerfologii Akademii Medycznej w Białymstoku.
authors.forename: J
authors.initials: J
authors.lastname: Małyszko
authors.forename: J
authors.initials: J
authors.lastname: Małyszko
authors.forename: M
authors.initials: M
authors.lastname: Myśliwiec
authors.forename: D
authors.initials: D
authors.lastname: Pawlak
authors.forename: W
authors.initials: W
authors.lastname: Buczko
mesh_terms: D000328:Adult; D001161:Arteriosclerosis / Q000209:etiology; D005342:Fibrinolysis / Q000502:physiology*; D005921:Glomerulonephritis / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology; D008875:Middle Aged; D012701:Serotonin / Q000097:blood*; D013923:Thromboembolism / Q000209:etiology; D010959:Tissue Plasminogen Activator / Q000378:metabolism
chemical_list: D012701:Serotonin; D010959:Tissue Plasminogen Activator