title: The therapeutic significance of pulse reverse osmosis.
abstract: Pulse reverse osmosis (1) is a new theory of fluid balance and exchange which suggests that the mean blood pressure and osmotic gradient control fluid balance and that the pulse controls fluid exchange. In vitro testing has confirmed some of the physico chemical principles underlying the theory (2). The hypothesis suggests a relationship between mean capillary blood pressure and osmotic gradient. Imbalance in this relationship can be related to the development of hypertension, hypotension, oedema and shock. In an attempt to test this concept mean blood pressures and colloid osmotic pressures were measured and compared in a group of 50 healthy human volunteers. The results suggest a curvilinear correlation between the mean blood pressure and the COP.
authors.affiliation: Osmosis Unit, Eastern General Hospital, Edinburgh, UK.
authors.forename: F G
authors.initials: FG
authors.lastname: Prior
authors.forename: V
authors.initials: V
authors.lastname: Morecroft
authors.forename: T
authors.initials: T
authors.lastname: Gourlay
authors.forename: K M
authors.initials: KM
authors.lastname: Taylor
mesh_terms: D001794:Blood Pressure / Q000502:physiology*; D001826:Body Fluids; D002199:Capillary Permeability / Q000502:physiology; D006331:Heart Diseases / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology; D009994:Osmolar Concentration; D011673:Pulsatile Flow