SSCP analysis of the tyrosine kinase domain of the insulin receptor gene: polymorphisms detected in South African black and white subjects.
The frequency of DNA polymorphisms in the tyrosine kinase domain (exons 17-21) of the insulin receptor gene was assessed in 30 black and 30 white South Africans, using single-stranded conformation polymorphism and direct sequencing analysis. A comparison of the frequencies of the normal versus the combined polymorphic alleles, found only in exon 17, showed a significant difference between black and white groups (P = 0.037).
Panz
V R
VR
Department of Medicine, University of the Witwatersrand Medical School, Johannesburg, South Africa.
Ruff
P
P
Joffe
B I
BI
Kedda
M A
MA
Seftel
H C
HC
D000328:Adult; D001483:Base Sequence; D044383:Black People / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D018807:Polymorphism, Single-Stranded Conformational; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D011972:Receptor, Insulin / Q000235:genetics*; D013019:South Africa; D044465:White People / Q000235:genetics*
D011505:Protein-Tyrosine Kinases; D011972:Receptor, Insulin