title: No evidence for linkage of chromosome 6p markers to schizophrenia in southern African Bantu-speaking families.
abstract: Previous studies have yielded evidence for a locus conferring susceptibility to schizophrenia and schizophrenia spectrum disorders on chromosome 6p24-22 in a sample of multiply affected Irish families. We tested for linkage between highly polymorphic chromosome 6p24-22 markers and narrowly defined schizophrenia in a sample of 19 Southern African Bantu-speaking families, a population known to have diverged in the last 2000 years. There is no evidence to support the linkage of markers in this region of chromosome 6 to schizophrenia in this population.
authors.affiliation: Department of Biochemistry and Molecular Genetics, St Mary's Hospital Medical School, Imperial College, London, UK.
authors.forename: B P
authors.initials: BP
authors.lastname: Riley
authors.forename: S
authors.initials: S
authors.lastname: Rajagopalan
authors.forename: M
authors.initials: M
authors.lastname: Mogudi-Carter
authors.forename: T
authors.initials: T
authors.lastname: Jenkins
authors.forename: R
authors.initials: R
authors.lastname: Williamson
mesh_terms: D044383:Black People / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6; D003198:Computer Simulation; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*; D013019:South Africa / Q000453:epidemiology
chemical_list: D005819:Genetic Markers