Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS.
Human metabotropic glutamate receptor type 7 (mGluR7) cDNA clones were isolated from a medulla cDNA library. The sequence, which includes a polymorphism, has 92% DNA sequence identity with rat mGluR7 and the predicted protein sequence has 99% identity. In-situ hybridization studies on human brain sections showed that mGluR7 mRNA has a widespread distribution with highest levels in the hippocampal formation, cerebral cortex and cerebellum.
Makoff
A
A
Biology Division, Wellcome Foundation, Kent, UK.
Pilling
C
C
Harrington
K
K
Emson
P
P
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000378:metabolism*; D003001:Cloning, Molecular; D006801:Humans; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D009474:Neurons / Q000378:metabolism*; D016376:Oligonucleotides, Antisense; D009928:Organ Specificity; D011110:Polymorphism, Genetic; D011689:Purkinje Cells / Q000378:metabolism; D017966:Pyramidal Cells / Q000378:metabolism; D051381:Rats; D018094:Receptors, Metabotropic Glutamate / Q000096:biosynthesis*; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid
D016376:Oligonucleotides, Antisense; D018094:Receptors, Metabotropic Glutamate; C102719:metabotropic glutamate receptor 7