title: Excretion of ketobemidone in human breast milk.
abstract: The excretion of ketobemidone into human breast milk was investigated in three women who obtained ketobemidone as postoperative pain relief after Cesarean section and two women premedicated with 5 mg of ketobemidone before currettage after delivery. The highest observed concentration of ketobemidone in breast milk was 36 ng/ml three hours after administration, and 4-7 hours after administration the concentration was 3-5 fold that in maternal plasma. It could be estimated that the newborn will be exposed to less than 2 micrograms of ketobemidone during the first 24 hours.
authors.affiliation: Department of Obstetrics and Gynaecology, University Hospital, Uppsala, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Gerdin
authors.forename: U
authors.initials: U
authors.lastname: Bondesson
authors.forename: P
authors.initials: P
authors.lastname: Hartvig
mesh_terms: D000701:Analgesics, Opioid / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D002585:Cesarean Section; D004350:Drug Residues / Q000032:analysis; D005260:Female; D006801:Humans; D008614:Meperidine / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics; D008895:Milk, Human / Q000737:chemistry / Q000378:metabolism*; D010149:Postoperative Pain / Q000188:drug therapy; D011247:Pregnancy
chemical_list: D000701:Analgesics, Opioid; D008614:Meperidine; C012394:ketobemidone