Sensitization studies with mometasone furoate, tixocortol pivalate, and budesonide in the guinea pig.
Mometasone furoate is a new corticosteroid, synthesized to have an improved ratio of anti-inflammatory potential to adverse effects. The guinea pig maximization test was used to determine the sensitizing capacity of mometasone furoate, and also to investigate cross-reaction patterns in animals sensitized to tixocortol pivalate and budesonide, respectively. Tixocortol pivalate was shown to be a sensitizer in the guinea pig, but cross-reactions to other tested corticosteroids were not observed. Furthermore, no sensitizing capacity could be demonstrated for budesonide or mometasone furoate.
Bruze
M
M
Department of Occupational Dermatology, University Hospital, Malmo, Sweden.
Bjorkner
B
B
Dooms-Goossens
A
A
D000279:Administration, Cutaneous; D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D019819:Budesonide; D003429:Cross Reactions; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D007114:Immunization; D007271:Injections, Intradermal; D000068656:Mometasone Furoate; D010328:Patch Tests; D011239:Prednisolone / Q000494:pharmacology; D011244:Pregnadienediols / Q000008:administration & dosage / Q000494:pharmacology*; D011282:Pregnenediones / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D014222:Triamcinolone Acetonide / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D011244:Pregnadienediols; D011282:Pregnenediones; D000068656:Mometasone Furoate; D019819:Budesonide; C019112:tixocortol pivalate; D011239:Prednisolone; D014222:Triamcinolone Acetonide; D006854:Hydrocortisone