Patterns of heart rate responses to hydralazine in normotensive and hypertensive rats.
Hydralazine (H) induces hypotension accompanied by cardiac stimulation due to activation of the arterial baroreflex. Both clinical and experimental observations suggest, however, that in certain conditions H hypotension can be accompanied by unchanged or even depressed cardiac performance. The present study determined whether varying patterns of heart rate responses could be detected in large populations of conscious normotensive (n = 61) and renal hypertensive (n = 59) rats receiving a single dose of H. These patterns were compared with those of normotensive pentobarbital-anesthetized rats (n = 43). In the three groups, hypotension was accompanied by either tachycardia, unchanged heart rate or bradycardia. Tachycardia was found in 52% of normotensive conscious rats, in 51% of hypertensives and in only 14% of anesthetized animals. Heart rate did not change in 26, 35 and 23%, while bradycardia was detected in 22, 14 and 63%, respectively. These results were explained by postulating the initiation by H of two reflexes with opposite effects on heart rate: the arterial baroreflex producing tachycardia and a cardiac mechanoreceptor reflex producing bradycardia. These reactions would compete with each other, with results depending on their relative sensitivity in a given animal.
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Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autonóma de México, México, D.F.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000633:toxicity; D017704:Baroreflex / Q000187:drug effects* / Q000502:physiology; D001919:Bradycardia / Q000139:chemically induced / Q000503:physiopathology; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006830:Hydralazine / Q000494:pharmacology* / Q000633:toxicity; D006977:Hypertension, Renal / Q000503:physiopathology*; D007022:Hypotension / Q000139:chemically induced* / Q000503:physiopathology; D008465:Mechanoreceptors / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013610:Tachycardia / Q000139:chemically induced / Q000503:physiopathology; D014665:Vasodilator Agents / Q000494:pharmacology* / Q000633:toxicity
D000959:Antihypertensive Agents; D014665:Vasodilator Agents; D006830:Hydralazine