High-resolution X-ray crystallography reveals precise binding interactions between human nonpancreatic secreted phospholipase A2 and a highly potent inhibitor (FPL67047XX).
Cha
S S
SS
Department of Life Science, Pohang University of Science and Technology, Kyungbuk, South Korea.
Lee
D
D
Adams
J
J
Kurdyla
J T
JT
Jones
C S
CS
Marshall
L A
LA
Bolognese
B
B
Abdel-Meguid
S S
SS
Oh
B H
BH
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001559:Benzhydryl Compounds / Q000737:chemistry* / Q000378:metabolism* / Q000627:therapeutic use; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003460:Crystallization; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D006860:Hydrogen Bonding; D051379:Mice; D008958:Models, Molecular; D010031:Otitis / Q000188:drug therapy; D010741:Phospholipases A / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism*; D054467:Phospholipases A2; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001559:Benzhydryl Compounds; D004791:Enzyme Inhibitors; C086203:FPL 67047XX; D005680:gamma-Aminobutyric Acid; D010741:Phospholipases A; D054467:Phospholipases A2