title: Synthesis of oligopeptides as polynucleotide analogs.
abstract: Several dipeptides which have a nucleic acid base in their side chains were designed as water-soluble nucleotide analogs. Amino acids having a uracil or adenine moiety in the gamma-position were synthesized and were connected with another amino acid (spacer) to afford dipeptides. The oligopeptides were prepared from the dipeptides as monomer units. Although all the oligopeptides having uracil moieties examined were water-soluble as expected, these exhibited no hypochromic effect with poly A or poly dA. Contrary, the oligopeptides with adenines exhibited large hypochromicity (ca. 30%) base-specifically with poly dT or poly U.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Umemiya
authors.forename: K
authors.initials: K
authors.lastname: Komatsu
authors.forename: T
authors.initials: T
authors.lastname: Yamazaki
authors.forename: H
authors.initials: H
authors.lastname: Kagechika
authors.forename: K
authors.initials: K
authors.lastname: Shudo
authors.forename: Y
authors.initials: Y
authors.lastname: Hashimoto
mesh_terms: D015394:Molecular Structure; D009696:Nucleic Acids / Q000737:chemistry; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D011061:Poly A / Q000737:chemistry; D011071:Poly T / Q000737:chemistry; D011072:Poly U / Q000737:chemistry; D011119:Polynucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D012995:Solubility; D014867:Water
chemical_list: D009696:Nucleic Acids; D009842:Oligopeptides; D011119:Polynucleotides; D014867:Water; D011061:Poly A; D011071:Poly T; C015465:poly(dA); D011072:Poly U