title: Increased airway pressure in response to xylazine is inhibited by both atipamezole and atropine in sheep.
abstract: The effect on airway pressure of xylazine alone or following the administration of atipamezole or atropine was studied in 31 halothane-anaesthetized sheep. Xylazine produced a significant increase in airway pressure which lasted for at least 30 min. This effect was inhibited by both atipamezole and atropine. The results suggest that the xylazine-induced increase in airway pressure in sheep is alpha 2-adrenergically mediated. Moreover, activation of central alpha 2-adrenoceptors leading to vagal stimulation may be involved.
authors.affiliation: Department of Surgery, Veterinary School, Aristotle University of Thessaloniki, Greece.
authors.forename: L
authors.initials: L
authors.lastname: Papazoglou
authors.forename: D
authors.initials: D
authors.lastname: Raptopoulos
authors.forename: N
authors.initials: N
authors.lastname: Kokolis
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001993:Bronchodilator Agents / Q000494:pharmacology*; D005260:Female; D007093:Imidazoles / Q000494:pharmacology*; D007385:Intermittent Positive-Pressure Ventilation / Q000662:veterinary; D011312:Pressure; D012143:Respiratory Physiological Phenomena; D012137:Respiratory System / Q000187:drug effects*; D012756:Sheep / Q000502:physiology*; D014991:Xylazine / Q000037:antagonists & inhibitors* / Q000494:pharmacology
chemical_list: D000317:Adrenergic alpha-Antagonists; D001993:Bronchodilator Agents; D007093:Imidazoles; C050701:atipamezole; D014991:Xylazine; D001285:Atropine