Acetaminophen plasma level after oral administration in liver cirrhotic patients suffering from schistosomal infection.
Hepatosplenic schistosomal infection is a common parasitic liver disease in Egypt, resulting in the formation of granuloma followed by fibrosis which leads to the chronic liver disease. Plasma level of acetaminophen (AAP) and its glucuronide and sulfate metabolites after oral administration at a dose of 1 g was determined in liver-cirrhotic younger (9 - 25 years old) and elderly patients (45 - 65 years old) suffering from schistosomal infection. These levels of AAP and its metabolites in patient groups were compared with those in corresponding healthy subject groups. Examinations for participants in the present study by physicians indicated the more severe cirrhosis in elderly patients compared to younger patients and the formation of collateral circulation and the renal insufficiency in elderly patients. The elimination of AAP from plasma was significantly prolonged in both younger and elderly patient groups. In elderly patients plasma concentration of AAP in early stage (before the time to reach Cmax) was significantly higher, indicating the partial avoidance of first-pass metabolism due to the formation of hepatic shunt pathway. Plasma concentration of AAP-glucuronide was greatly decreased in both patient groups, whereas no significant difference in the plasma concentration of AAP-sulfate compared to those in corresponding healthy subject groups. These results will suggest that with repeated dosing of AAP special care must be taken in schistosomal patients since the elimination of AAP from plasma is remarkably reduced.
el-Azab
G
G
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Japan.
Youssef
M K
MK
Higashi
Y
Y
Murakami
T
T
Yata
N
N
D000082:Acetaminophen / Q000097:blood* / Q000652:urine; D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism; D018712:Analgesics, Non-Narcotic / Q000097:blood* / Q000652:urine; D001682:Biological Availability; D001711:Biotransformation; D002648:Child; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000209:etiology / Q000652:urine; D008297:Male; D008875:Middle Aged; D012552:Schistosomiasis / Q000097:blood* / Q000150:complications / Q000469:parasitology
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen