title: Pharmacokinetics of oral fleroxacin in male and premenopausal female volunteers.
abstract: The pharmacokinetics of oral fleroxacin were compared in men and premenopausal women. The total volume of distribution of the drug was significantly smaller in women in the single-dose trial. No difference in other pharmacokinetic parameters was noted. Since adverse events appear to occur in women more commonly than in men, dose-response studies of fleroxacin in women may be appropriate.
authors.affiliation: Department of Pharmacy Services, Bassett Healthcare, Cooperstown, New York 13326-1394, USA. jbertino@cscns.com
authors.forename: J S
authors.initials: JS
authors.lastname: Bertino
authors.forename: A N
authors.initials: AN
authors.lastname: Nafziger
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D005260:Female; D016576:Fleroxacin / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D012727:Sex Characteristics
chemical_list: D000890:Anti-Infective Agents; D016576:Fleroxacin