Stability of vancomycin in plastic syringes measured by high-performance liquid chromatography.
The shelf-life of vancomycin in infusion fluids was studied using high-performance liquid chromatographic (HPLC) methods. Vancomycin was stable (loss in potency less than 10%) for 47 days and 29 days, respectively, when dissolved in water-for-injections BP at 25 degrees C and stored in plastic syringes (Becton Dickinson Plastipak (three-piece) and B. Braun Medical Injekt (two-piece)). In sodium chloride solution (0.9%; pH 5.4) it was stable for 62 and 34 days, while in dextrose solution (5%; pH 4.2) it was stable for 55 and 33 days, respectively, at the same temperature. At 4 degrees C vancomycin was stable in all three infusion fluids and both types of syringe for at least 84 days.
Wood
M J
MJ
Pharmacy Department, Queen Elizabeth Hospital, Birmingham, U.K.
Lund
R
R
Beavan
M
M
D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D012996:Solutions; D013594:Syringes; D013696:Temperature; D014640:Vancomycin / Q000737:chemistry*
D012996:Solutions; D014640:Vancomycin