Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of beta-amyloid(1-40) protein.
We have previously shown that the continuous intracerebroventricular infusion of beta-amyloid(1-40) protein results in memory impairments in rats, associated with a reduction of choline acetyltransferase activity in the frontal cortex and hippocampus. In the present study, we examined whether the infusion of beta-amyloid(1-40) protein affected the content of ciliary neurotrophic factor (CNTF) in the rat brain. The beta-amyloid(1-40) infusion increased CNTF content in the frontal cortex, hippocampus, and the cerebellum, but decreased its content in the brain stem. These results suggest that accumulation of beta-amyloid(1-40) in the brain may affect CNTF production in vivo.
Yamada
K
K
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Showa-ku, Japan.
Nitta
A
A
Saito
T
T
Hu
J
J
Nabeshima
T
T
D016229:Amyloid beta-Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D020934:Ciliary Neurotrophic Factor; D003864:Depression, Chemical; D007124:Immunoenzyme Techniques; D007276:Injections, Intraventricular; D008297:Male; D009414:Nerve Growth Factors / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D016229:Amyloid beta-Peptides; D020934:Ciliary Neurotrophic Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D010446:Peptide Fragments