Cloning of PL33: a novel probable serpentine membrane receptor associated with human cytotrophoblast and lineage-specific HL-60 cell differentiation.
From a subtracted library of differentiating human cytotrophoblast cells, we have cloned a gene termed PL33, a novel probable member of the G-protein-linked seven transmembrane domain receptor family. The 496 amino acid open reading frame of PL33 codes for a protein of predicted molecular weight of 54.7 kDa. Northern blot analysis shows that the two mRNA transcripts of PL33 are expressed in testes, keratinocytes, differentiating cytotrophoblast and in monocyte/macrophage lineage-specific HL-60 cell differentiation.
Morrish
D W
DW
Department of Medicine, University of Alberta, Edmonton, Canada. dmorrish@gpu.srv.ualberta.ca
Dakour
J
J
Li
H
H
D000595:Amino Acid Sequence; D000943:Antigens, Differentiation / Q000235:genetics; D001483:Base Sequence; D002454:Cell Differentiation; D019070:Cell Lineage; D003001:Cloning, Molecular; D018922:HL-60 Cells; D006801:Humans; D008562:Membrane Glycoproteins; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins; D011956:Receptors, Cell Surface / Q000235:genetics*; D014327:Trophoblasts / Q000378:metabolism*
D000943:Antigens, Differentiation; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D011956:Receptors, Cell Surface; C103949:SERINC3 protein, human