A semicompartmental modeling approach for pharmacodynamic data assessment.
A new method is proposed for modeling the temporal aspects of the pharmacodynamic-pharmacokinetic relationship of drugs. A semicompartmental solution to the effect-site link model of Sheiner et al. (1) formed the basis for this new approach. This semicompartmental solution does not require the specification of a compartmental model for the pharmacokinetic response and may offer an advantage when model misspecification is present in using standard compartmental models. A Monte Carlo simulation study was conducted to evaluate the performance of the semicompartmental modeling approach. This method is easily implemented in standard nonlinear regression packages.
Kowalski
K G
KG
Department of Statistics and Clinical Data Management, Searle Research and Development, Skokie, Illinois 60077, USA.
Karim
A
A
D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D007262:Infusions, Intravenous; D008954:Models, Biological; D009010:Monte Carlo Method; D017711:Nonlinear Dynamics; D010599:Pharmacokinetics; D010880:Piperidines / Q000008:administration & dosage / Q000493:pharmacokinetics; D012044:Regression Analysis; D012984:Software
D000889:Anti-Arrhythmia Agents; D010880:Piperidines; C061991:bidisomide