Bovine collagen induced systemic symptoms: antibody formation against bovine and human collagen.
We describe the first case of systemic symptoms after injection of bovine collagen and silicone polymers associated with antibodies to both native type I and II bovine and human collagen that varied with clinical features. Joint inflammation, edema at the injection site of bovine collagen implant and fever appeared 6 months after injection. Our patients history raises the question of whether the injection of animal derived collagen, particularly combined with silicone, induces or exacerbates autoimmune disease.
Bonnet
C
C
Service de Rhumatologie, CHRU Dupuytren, Limoges, France.
Charriere
G
G
Vaquier
J
J
Bertin
P
P
Vergne
P
P
Treves
R
R
D000328:Adult; D000818:Animals; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000139:chemically induced* / Q000276:immunology; D002417:Cattle; D003094:Collagen / Q000009:adverse effects* / Q000276:immunology; D005260:Female; D006801:Humans; D019736:Prostheses and Implants / Q000009:adverse effects*
D001323:Autoantibodies; D003094:Collagen