title: Shape of the human corpus callosum in childhood. Elliptic Fourier analysis on midsagittal magnetic resonance scans.
abstract: OBJECTIVE
  The authors previously investigated the midsagittal magnetic resonance images of neurologically intact adults, and analyzed the shape of corpus callosum from a mathematic standpoint. Significant effects of age were demonstrated, without significant sex differences. In the current study, the same mathematic method was applied to analyze the sex and age shape differences of the human corpus callosum in childhood.
  
  
  METHODS
  On the midsagittal magnetic resonance images of 84 neurologically intact children (39 boys, 45 girls, aged 4 months to 15 years) the outline of the corpus callosum was identified. Its shape was quantified using elliptic Fourier analysis, which allows for global evaluation of the shape of organs identified by their outlines independently from size, spatial orientation, and relationship to reference planes. Subjects were grouped by sex and age.
  
  
  RESULTS
  The shape of the corpus callosum within age and sex classes in childhood was more homogeneous than in adulthood. A significant effect of age was demonstrated by the analysis of variance; however, no significant sex differences were found.
  
  
  CONCLUSIONS
  Corpus callosum shape in midsagittal magnetic resonance images was strongly influenced by central nervous system development and aging, but the influence of sex was not sufficient to be detected by current standard magnetic resonance imaging technology, and by the available sample sizes. The current investigation supplies data on the normal callosal shape in the first two decades of life, thus completing previous analysis.
authors.affiliation: Laboratorio di Anatomia Funzionale dell'Apparato Stomatognatico, Universita' degli Studi, Milano, Italy.
authors.forename: V F
authors.initials: VF
authors.lastname: Ferrario
authors.forename: C
authors.initials: C
authors.lastname: Sforza
authors.forename: G
authors.initials: G
authors.lastname: Serrao
authors.forename: T
authors.initials: T
authors.lastname: Frattini
authors.forename: C
authors.initials: C
authors.lastname: Del Favero
mesh_terms: D000293:Adolescent; D000375:Aging; D000704:Analysis of Variance; D002648:Child; D002675:Child, Preschool; D003337:Corpus Callosum / Q000033:anatomy & histology* / Q000254:growth & development; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007091:Image Processing, Computer-Assisted; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012189:Retrospective Studies; D012727:Sex Characteristics