Antimutagenic activity of alkylresorcinols from cereal grains.
Alkylresorcinols, natural amphiphilic compounds commonly found in cereal grains, markedly decreased mutagenic activity of four standard mutagens examined in the Ames test. The effect was the strongest in the case of indirect-acting mutagens, benzo[a]pyrene and 2-aminofluorene. In the case of direct-acting mutagens, daunorubicin and methyl methanesulfonate, the diminution of the mutagenic activity by the alkylresorcinols was smaller but still noticeable. In the Sister Chromatid Exchanges test (SCEs) with cultured in vitro human blood-derived lymphocytes, a significant decrease of SCEs frequency induced by benzo[a]pyrene was observed in the presence of alkylresorcinols. These preliminary results seem to be important in the aspect of possible antimutagenic and anticarcinogenic potency of alkylresorcinols found in cereal grains.
Gasiorowski
K
K
Department of Basic Medical Sciences, Medical Academy, Wroclaw, Poland.
Szyba
K
K
Brokos
B
B
Kozubek
A
A
D016587:Antimutagenic Agents / Q000494:pharmacology*; D001564:Benzo(a)pyrene / Q000633:toxicity; D002478:Cells, Cultured; D003630:Daunorubicin / Q000633:toxicity; D002523:Edible Grain; D005449:Fluorenes / Q000633:toxicity; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000502:physiology; D008741:Methyl Methanesulfonate / Q000633:toxicity; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D012044:Regression Analysis; D012118:Resorcinols / Q000302:isolation & purification / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects; D012854:Sister Chromatid Exchange / Q000187:drug effects
D016587:Antimutagenic Agents; D005449:Fluorenes; D009153:Mutagens; D012118:Resorcinols; D001564:Benzo(a)pyrene; C012177:2-aminofluorene; D008741:Methyl Methanesulfonate; D003630:Daunorubicin