The effects of opiates and opioid neuropeptides on mosquito hemocytes.
The effects of morphine, Met-enkephalin, and its synthetic analogue DAMA on the hemocytes of Culex pipiens mosquitoes were examined in vitro. Morphine caused the cells to round up and decrease in area. Met-enkephalin caused the cells to become ameboid and increase in area. This effect was accentuated with the addition of the neutral endopeptidase blocker phosphoramidon. DAMA caused a similar but greater enhancement of immune activation which was blocked by the opiate antagonist, naloxone. These results were similar to those seen in other invertebrate hemocytes.
Pryor
S C
SC
Old Westbury Neuroscience Research Institute, State University of New York 11568, USA.
Fascher
E
E
D000818:Animals; D048429:Cell Size / Q000187:drug effects; D003465:Culex / Q000166:cytology / Q000187:drug effects* / Q000276:immunology*; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives / Q000494:pharmacology; D006020:Glycopeptides / Q000494:pharmacology; D006434:Hemocytes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D066298:In Vitro Techniques; D009020:Morphine / Q000494:pharmacology; D009294:Narcotics / Q000494:pharmacology*; D015260:Neprilysin / Q000037:antagonists & inhibitors; D018847:Opioid Peptides / Q000494:pharmacology*; D011480:Protease Inhibitors / Q000494:pharmacology
D006020:Glycopeptides; D009294:Narcotics; D018847:Opioid Peptides; D011480:Protease Inhibitors; D004744:Enkephalin, Methionine; C022118:enkephalinamide-Met, Ala(2)-; D009020:Morphine; D015260:Neprilysin; C008890:phosphoramidon