Effects of estrone with or without medroxyprogesterone acetate on the femur in aged rats.
In an attempt to define the efficacy of hormone replacement therapy in postmenopausal osteoporosis, we investigated the effects of estrone with or without medroxyprogesterone acetate on the bone mineral density of the femur of aged rats, of which plasma levels of luteinizing hormone (LH), follicle stimulating hormone (FSH) and estradiol were markedly reduced in comparison with those of younger rats. Although additional sex hormones had little effect on the plasma levels of gonadotropins, chronic administration of estrone significantly enhanced the bone mineral density of femur in aged animals.
Sassa
S
S
Department of Endocrinology, Tokyo Medical and Dental University, Japan.
Shinoda
H
H
Kudo
H
H
Suzuki
S
S
Kuwa
K
K
Yoshimura
S
S
Maemura
M
M
Nakayama
T
T
Mitamura
T
T
Sakamoto
S
S
D000375:Aging; D000818:Animals; D015519:Bone Density; D004970:Estrone / Q000494:pharmacology*; D005260:Female; D005269:Femur / Q000187:drug effects / Q000378:metabolism*; D005640:Follicle Stimulating Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D017258:Medroxyprogesterone Acetate / Q000494:pharmacology*; D009929:Organ Size; D051381:Rats; D017207:Rats, Sprague-Dawley
D004970:Estrone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D017258:Medroxyprogesterone Acetate