The effects of theophylline on metabolic rate in chronic obstructive lung disease patients.
OBJECTIVE
To study the effect of theophylline and an alternative bronchodilator, ipratropium, on resting energy expenditure (REE) and thermic effect of food (TEF).


METHODS
5-week randomized, repeated measures, double-blind, cross-over design, comparing the effects of theophylline and ipratropium drug treatments on metabolic measurements made during a baseline period.


METHODS
Ambulatory Clinical Trials Center at University of California, San Diego.


METHODS
14 patients at least 65 years old with a clinical diagnosis of chronic obstructive pulmonary disease.


METHODS
Resting energy expenditure and thermic effect of food were measured by indirect calorimetry. Body composition was determined using bioimpedance.


RESULTS
Resting energy expenditure did not differ between baseline and either of the two drug treatments. In men, the thermic effect of food increased significantly during theophylline and ipratropium drug treatment periods (p < 0.03).


CONCLUSIONS
Theophylline or ipratropium does not appear to increase resting energy expenditure in patients with chronic obstructive lung disease. The elevated values for thermic effect of food in men need further study.
Mosier
K
K
Division of General Internal Medicine/Geriatrics, University of California, San Diego 92103-8415, USA.
Renvall
M J
MJ
Ramsdell
J W
JW
Spindler
A A
AA
D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001823:Body Composition; D001833:Body Temperature Regulation / Q000187:drug effects* / Q000502:physiology; D001993:Bronchodilator Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002153:Calorimetry, Indirect; D018592:Cross-Over Studies; D004311:Double-Blind Method; D002149:Energy Intake; D004734:Energy Metabolism / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D009241:Ipratropium / Q000494:pharmacology / Q000627:therapeutic use; D008173:Lung Diseases, Obstructive / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D012146:Rest; D013806:Theophylline / Q000494:pharmacology* / Q000627:therapeutic use
D001993:Bronchodilator Agents; D013806:Theophylline; D009241:Ipratropium