Antibacterial activity of some Garcinia benzophenone derivatives against methicillin-resistant Staphylococcus aureus.
Benzophenone derivatives, garcinol (1) and isogarcinol (2) isolated from the pericarps of Garcinia purpurea (Guttiferae), and xanthochymol (3) and a mixture of isoxanthochymol (4) cycloxanthochymol (5) from the pericarps of G. subelliptica were evaluated for their antibacterial activity against methicillin-resistant Staphylococcus aureus. Among them, 3 showed the lowest minimum inhibitory concentration at 3.1-12.5 micrograms/ml. This concentration is nearly equal to that of the antibiotic, vancomycin.
Iinuma
M
M
Department of Pharmacognosy, Gifu Pharmaceutical University, Japan.
Tosa
H
H
Tanaka
T
T
Kanamaru
S
S
Asai
F
F
Kobayashi
Y
Y
Miyauchi
K
K
Shimano
R
R
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001577:Benzophenones / Q000494:pharmacology*; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects*; D013729:Terpenes / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001577:Benzophenones; D013729:Terpenes; C054597:garcinol