Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion.
We report a case of a 44-year-old woman who developed Fanconi's syndrome in association with the oral ingestion of L-lysine. L-lysine is widely available in health food stores and has been recommended in the lay press for the treatment and prevention of recurrent herpes simplex. The development of a severe tubulointerstitial nephritis, and eventual progression to chronic renal failure, underscores the importance of this entity, heretofore unrecognized in humans.
Lo
J C
JC
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Chertow
G M
GM
Rennke
H
H
Seifter
J L
JL
D000328:Adult; D005198:Fanconi Syndrome / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006561:Herpes Simplex / Q000517:prevention & control; D006801:Humans; D007668:Kidney / Q000648:ultrastructure; D008239:Lysine / Q000506:poisoning* / Q000627:therapeutic use; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology
D008239:Lysine