title: Production of anti-erythrocyte antibodies by leukemic and nonleukemic B cells in chronic lymphocytic leukemia patients.
abstract: We have assessed the specificity of antibodies from the leukemic B cells of five patients with both chronic lymphocytic leukemia and autoimmune hemolytic anemia (CLL-AHA). Leukemic cells from one patient displayed surface immunoglobulin with heavy and light chain isotypes identical to that of the patient's anti-red blood cell (RBC) antibodies, and the leukemic cells secreted antibodies in vitro with anti-RBC activity. However, in the remaining patients, the leukemic cells displayed surface immunoglobulin with light chain isotypes different from that of the patient's anti-RBC antibodies and secreted antibodies in vitro with no detectable anti-RBC activity. Thus, there are two distinct classes of CLL-AHA patients, differentiated by the presence or absence of an anti-RBC antibody-producing leukemic B cell clone. The apparent heterogeneity in the source of pathogenic anti-RBC antibodies may impact the treatment response of the two classes of CLL-AHA patients.
authors.affiliation: XOMA Corporation, Santa Monica, California, USA.
authors.forename: M
authors.initials: M
authors.lastname: Centola
authors.forename: K
authors.initials: K
authors.lastname: Lin
authors.forename: C
authors.initials: C
authors.lastname: Sutton
authors.forename: J R
authors.initials: JR
authors.lastname: Berenson
authors.forename: L A
authors.initials: LA
authors.lastname: Kunkel
authors.forename: L
authors.initials: L
authors.lastname: Rosen
authors.forename: B H
authors.initials: BH
authors.lastname: Hahn
authors.forename: R R
authors.initials: RR
authors.lastname: Robinson
mesh_terms: D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000209:etiology* / Q000276:immunology; D000918:Antibody Specificity; D001323:Autoantibodies / Q000096:biosynthesis* / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D015328:Gene Rearrangement, B-Lymphocyte, Light Chain; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000276:immunology; D007132:Immunoglobulin Isotypes / Q000096:biosynthesis / Q000276:immunology; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000276:immunology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000276:immunology; D014411:Neoplastic Stem Cells / Q000276:immunology* / Q000473:pathology; D011947:Receptors, Antigen, B-Cell / Q000096:biosynthesis* / Q000276:immunology
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes; D007075:Immunoglobulin M; D009363:Neoplasm Proteins; D011947:Receptors, Antigen, B-Cell