title: Maltitol increases transepithelial diffusional transfer of calcium in rat ileum.
abstract: We explored the mechanism whereby maltitol causes an increase of calcium absorption in the lower small intestine using everted ileal segments of rats. Under the calcium concentrations tested (1-20mM), which enabled us to assess the diffusional calcium transfer, maltitol in the mucosal-side medium (100mM) caused a 155% greater transepithelial calcium transfer as compared with the segments incubated without sugars. The maltitol-induced increment of calcium transfer was significantly higher than those elicited by glucose, sorbitol and maltose, and this increase was completely inhibited by W7, a calmodulin antagonist. Thus, our results suggest that maltitol might modulate the permeability of calcium through paracellular path, which possibly involves the activation of calmodulin.
authors.affiliation: Department of Nutrition, University of Shizuoka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kishi
authors.forename: T
authors.initials: T
authors.lastname: Goda
authors.forename: S
authors.initials: S
authors.lastname: Takase
mesh_terms: D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D002147:Calmodulin / Q000037:antagonists & inhibitors; D004058:Diffusion; D004848:Epithelium / Q000378:metabolism; D005947:Glucose / Q000494:pharmacology; D007082:Ileum / Q000378:metabolism*; D008297:Male; D008320:Maltose / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013012:Sorbitol / Q000494:pharmacology; D013402:Sugar Alcohols / Q000494:pharmacology*; D013449:Sulfonamides / Q000494:pharmacology
chemical_list: D002147:Calmodulin; D013402:Sugar Alcohols; D013449:Sulfonamides; D013012:Sorbitol; C017967:W 7; D008320:Maltose; C010745:maltitol; D005947:Glucose; D002118:Calcium