title: Differential role of nitric oxide in long-term potentiation in the medial and lateral amygdala.
abstract: The effects of nitric oxide (NO) donors on the induction of long-term potentiation in the amygdala were investigated using rat brain slice preparations in vitro. In the medial amygdala synapses, sodium nitroprusside (10 microM) and hydroxylamine (100 microM), when applied together with a weak tetanic stimulation, significantly facilitated the induction of long-term potentiation. The NO donors showed no effect in the lateral amygdala synapses. These results suggest that NO plays a role in facilitating the induction of long-term potentiation in the medial amygdala but not in the lateral amygdala.
authors.affiliation: Department of Chemical Pharmacology, University of Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Abe
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Saito
mesh_terms: D000679:Amygdala / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation; D006454:Hemoglobins / Q000494:pharmacology; D019811:Hydroxylamine; D006898:Hydroxylamines / Q000494:pharmacology; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009569:Nitric Oxide / Q000502:physiology*; D009599:Nitroprusside / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D006454:Hemoglobins; D006898:Hydroxylamines; D009599:Nitroprusside; D019811:Hydroxylamine; D009569:Nitric Oxide