Translocation t(10;11) involving the MLL gene in acute myeloid leukemia. Importance of fluorescence in situ hybridization (FISH) analysis.
Fluorescence in situ hybridization analysis in an infant with acute monocytic leukemia revealed a complex translocation, t(10;11;4) (p12; q23;q26). Southern blot analysis confirmed the existence of rearrangement of the MLL gene. The frequent occurrence of complex translocations involving 10p12 and 11q23 is discussed in function of the opposite orientation of the AF10 and MLL genes on 10p and 11q. The importance of FISH analysis in t(10; 11) is emphasized.
Berger
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R
Unité INSERM U 301, Institut de Génétique Moléculaire, Paris, France.
Le Coniat
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M
Flexor
M A
MA
Leblanc
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T
D002879:Chromosomes, Human, Pair 10 / Q000235:genetics / Q000648:ultrastructure*; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics / Q000648:ultrastructure*; D004268:DNA-Binding Proteins / Q000235:genetics*; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007948:Leukemia, Monocytic, Acute / Q000235:genetics* / Q000473:pathology; D008297:Male; D051788:Myeloid-Lymphoid Leukemia Protein; D011519:Proto-Oncogenes; D014157:Transcription Factors; D014178:Translocation, Genetic
D004268:DNA-Binding Proteins; C497422:KMT2A protein, human; D014157:Transcription Factors; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase