Influence of gallopamil on the gastric effects of stress in conscious rats.
The influence of the calcium-channel blocker gallopamil on cold-restraint stress (CRS)-induced gastric effects was investigated in conscious rats with gastric cannula. CRS, while leading to multiple gastric lesions, reduced gastric acid output and mast cell count, but increased the gastric emptying rate of acid solutions. Intraperitoneally injected gallopamil (1 mg/kg), given 1 h before CRS administration, prevented gastric lesion formation and partially reversed mast cell count and the emptying of acid solutions, but had no further effect on acid output. However, gallopamil in unrestrained rats did not significantly affect acid emptying or mast cell count. Regarding calcium involvement in the pathophysiology of stress-induced gastric lesions, the possible antiulcer actions of gallopamil involved in the prevention of CRS-induced lesion formation may be attributed to its putative stabilizing effect on mast cells and gastric emptying.
Coşkun
T
T
Department of Physiology, Marmara University, School of Medicine, Istanbul, Turkey.
Alican
I
I
Gürbüz
V
V
Corak
A
A
Cetinel
S
S
Kurtel
H
H
Yeğen
B C
BC
D000818:Animals; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D005711:Gallopamil / Q000627:therapeutic use*; D005744:Gastric Acid / Q000378:metabolism*; D005746:Gastric Emptying / Q000187:drug effects*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008407:Mast Cells / Q000473:pathology; D010437:Peptic Ulcer / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological / Q000188:drug therapy*
D002121:Calcium Channel Blockers; D005711:Gallopamil