Activities of RPR 106972 (a new oral streptogramin), cefditoren (a new oral cephalosporin), two new oxazolidinones (U-100592 and U-100766), and other oral and parenteral agents against 203 penicillin-susceptible and -resistant pneumococci.
Agar dilution was used to determine the MICs of RPR 106972 (a new oral streptogramin), cefditoren (a new oral cephalosporin), two new oxazolidinones (U-100592 and U-100766), and other oral and parenteral agents for 203 penicillin-susceptible and -resistant pneumococci. All pneumococci were inhibited by RPR 106972 at < or = 0.5 microgram/ml. Cefditoren was very active against all pneumococcal groups, with MICs of < or = 2.0 micrograms/ml. Amoxicillin with or without clavulanate was the next most active oral beta-lactam, followed by cefdinir, cefuroxime, cefpodoxime, and cefprozil. U-100592 and U-100766 were very active against all classes of pneumococci, with all MICs < or = 1.0 microgram/ml.
Spangler
S K
SK
Department of Pathology (Clinical Microbiology), Hershey Medical Center, Pennsylvania 17033, USA.
Jacobs
M R
MR
Appelbaum
P C
PC
D000081:Acetamides / Q000494:pharmacology; D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010080:Oxazoles / Q000494:pharmacology; D023303:Oxazolidinones; D010403:Penicillin Resistance; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D014769:Virginiamycin / Q000737:chemistry / Q000494:pharmacology
D000081:Acetamides; D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D010080:Oxazoles; D023303:Oxazolidinones; C099364:RPR 106972; D014769:Virginiamycin; C073460:cefditoren; C098011:eperezolid; D000069349:Linezolid