Pharmacological considerations for the pediatric patient.
The use of pharmacological agents in children warrants special consideration because children have variable pharmacokinetic parameters. Not only are the pharmacokinetic properties of drugs different in children as compared with adults, but these properties can undergo rapid change as children grow and mature. Furthermore, many drugs that would be useful in the pediatric population lack the indication for use in children and, therefore, dosing guidelines are not available. This paper presents an overview of basic pharmacokinetics in children and pediatric dosing guidelines.
Blaho
K
K
Department of Emergency Medicine and Clinical Toxicology, University of Tennessee Medical Group, Memphis, USA.
Winbery
S
S
Merigian
K
K
D000042:Absorption; D000305:Adrenal Cortex Hormones / Q000493:pharmacokinetics / Q000494:pharmacology; D000700:Analgesics / Q000493:pharmacokinetics / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology; D001682:Biological Availability; D002648:Child; D004304:Dosage Forms; D004358:Drug Therapy; D006634:Histamine H1 Antagonists / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D010372:Pediatrics; D014815:Vitamins / Q000493:pharmacokinetics / Q000494:pharmacology
D000305:Adrenal Cortex Hormones; D000700:Analgesics; D000900:Anti-Bacterial Agents; D004304:Dosage Forms; D006634:Histamine H1 Antagonists; D014815:Vitamins