Nerval influences on liver cytochrome P450.
In male young adult Wistar rats the influences of nucleus raphe electrocoagulation, spinal cord dissection (cordotomy between C7 and Th1), vagotomy and denervation of liver hilus by phenol on liver cytochrome P450-system (cytochrome P450 concentration, ethylmorphine N-demethylation and ethoxycoumarin O-deethylation activities, hexobarbitone sleeping time) were investigated. In general the influences were small or negligible when compared with sham operated controls, only after vagotomy the depressing effect of sham operation was abolished. In all cases sham operation had a depressing effect until up to five weeks after operation.
Klinger
W
W
Institute of Pharmacology and Toxicology, Jena, Germany.
Karge
E
E
Danz
M
M
Krug
M
M
D015660:7-Alkoxycoumarin O-Dealkylase / Q000032:analysis; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis*; D003714:Denervation; D004564:Electrocoagulation; D005037:Ethylmorphine-N-Demethylase / Q000032:analysis; D008099:Liver / Q000201:enzymology* / Q000294:innervation* / Q000502:physiology; D008297:Male; D011903:Raphe Nuclei / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000502:physiology; D013238:Stereotaxic Techniques; D014630:Vagus Nerve / Q000502:physiology
D003577:Cytochrome P-450 Enzyme System; D015660:7-Alkoxycoumarin O-Dealkylase; D005037:Ethylmorphine-N-Demethylase