Urodilatin is involved in sodium homeostasis and exerts sodium-state-dependent natriuretic and diuretic effects.
Urodilatin is involved in sodium homeostasis exerts sodium-state-dependent natriuretic and diuretic cts. Eight male volunteers participated in a study consisting of three consecutive phases of 7 days each. The volunteers a sodium diet with 52, 172.6, and 347.8 mmol um/day. Sodium excretion increased from 57.4 +/- 3.7 via .8 +/- 4.6 (P < 0.001) to 322.5 +/- 10.2 mmol/24 h (P < 0.001) at the end of each sodium diet. Urinary urodilatin excretion increased from 24.8 +/- 3.0 via 35.5 +/- 9.0 (P = 0.07) to 49.0 = mol/min (P < 0.01). At the end of each diet, urodilatin was infused for 2 h at 20 ng.kg body wt-1.min-1. Natriuresis increased after low- (4.1 to 52.9 mmol/h, P < 0.001), normal (6.9 to 44.9 mmol/h, P < 0.05), and high-sodium diet (20.1 to 102.9 mmol/h, P < 0.001). Diuresis increased from 174 to 709 (P < 0.001), 395 to 1,026 (P < 0.05), and 266 to 1,339 ml/h < 0.001). The present results indicate that endogenous urodilatin plays an important role in sodium homeostasis and that renal response to exogenous urodilatin is modulated by sodium balance.
Meyer
M
M
Department of Nephrology, Hannover Medical School, Germany.
Richter
R
R
Brunkhorst
R
R
Wrenger
E
E
Schulz-Knappe
P
P
Kist
A
A
Mentz
P
P
Brabant
E G
EG
Koch
K M
KM
Rechkemmer
G
G
Forssmann
W G
WG
D000222:Adaptation, Physiological; D000328:Adult; D009320:Atrial Natriuretic Factor / Q000494:pharmacology / Q000502:physiology* / Q000652:urine; D004039:Diet, Sodium-Restricted; D004231:Diuresis / Q000187:drug effects / Q000502:physiology*; D004232:Diuretics; D006706:Homeostasis; D006801:Humans; D008297:Male; D009318:Natriuresis / Q000187:drug effects / Q000502:physiology*; D010446:Peptide Fragments / Q000494:pharmacology / Q000502:physiology* / Q000652:urine; D012964:Sodium / Q000378:metabolism*
D004232:Diuretics; D010446:Peptide Fragments; C056452:Ularitide; D009320:Atrial Natriuretic Factor; D012964:Sodium