Sequence analyses of human parainfluenza virus type 4A and type 4B fusion proteins.
cDNAs encoding human parainfluenza virus type 4A and type 4B (hPIV-4A and -4B) fusion (F) proteins were cloned and sequenced. The predicted amino acid sequences of the F proteins had similar characteristic traits to those reported for the F proteins of other paramyxoviruses. They were more closely related to the F proteins of simian virus 5 (SV5), mumps virus (MuV), hPIV-2 and Newcastle disease virus (NDV) than to the F proteins of hPIV-1, hPIV-3, Sendai virus (SV) and measles virus (MV). In addition, hPIV-4A, hPIV-4B, SV5 and MuV shared a common feature of genomic organization: there was a small ORF between the F and haemagglutinin-neuraminidase (HN)-coding sequences, implying a common ancestry.
Komada
H
H
Department of Microbiology, Mie University School of Medicine, Japan.
Bando
H
H
Ito
M
M
Ohta
H
H
Kawano
M
M
Nishio
M
M
Tsurudome
M
M
Watanabe
N
N
Ikemura
N
N
Kusagawa
S
S
D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics; D005814:Genes, Viral / Q000235:genetics; D015707:HN Protein / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D018098:Paramyxovirinae / Q000235:genetics; D018108:Respirovirus / Q000737:chemistry / Q000235:genetics*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D014760:Viral Fusion Proteins / Q000737:chemistry / Q000235:genetics*; D015678:Viral Structural Proteins / Q000235:genetics
D018076:DNA, Complementary; D015707:HN Protein; D014760:Viral Fusion Proteins; D015678:Viral Structural Proteins; C097258:fusion protein, human parainfluenza virus type 4