title: Paget's disease of bone and unvaccinated dogs.
abstract: The etiology of Paget's disease is unknown, but several observations suggest a viral cause. Since canine distemper virus is among those proposed to be a causal agent, we investigated the hypothesis that dog ownership may increase the risk of Paget's disease of bone by means of a case control study. One hundred and fifty patients with Paget's disease and 185 controls were interviewed using a structured questionnaire administered by the same interviewer. Participants were asked about their socioeconomic background and their exposure to pets. The risk of Paget's disease was not significantly increased in individuals. However, ownership of a mongrel dog was associated with a significant increase in risk (OR = 1.6; 95% CI = 1.0-2.4) and the risk increased still further with the ownership of an unvaccinated dog (OR = 2.8; 95% CI = 1.8-4.5). Additionally, ownership of cats and birds excluding dog owners, increased the risk of Paget's disease (OR = 2.5; 95% CI = 1.0-5.0; OR = 2.3; 95% CI = 1.0-5.3, respectively). These data suggest that previous exposure to cats, birds, and dogs unvaccinated for canine distemper may increase the risk of an individual developing Paget's disease of bone.
authors.affiliation: WHO Collaborating Centre for Metabolic Bone Disease, Department of Human Metabolism and Clinical Biochemistry, University of Sheffield Medical School, UK.
authors.forename: S A
authors.initials: SA
authors.lastname: Khan
authors.forename: P
authors.initials: P
authors.lastname: Brennan
authors.forename: J
authors.initials: J
authors.lastname: Newman
authors.forename: R E
authors.initials: RE
authors.lastname: Gray
authors.forename: E V
authors.initials: EV
authors.lastname: McCloskey
authors.forename: J A
authors.initials: JA
authors.lastname: Kanis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000829:Animals, Domestic / Q000821:virology*; D000914:Antibodies, Viral / Q000276:immunology*; D001717:Birds; D001847:Bone Diseases / Q000209:etiology* / Q000821:virology; D016022:Case-Control Studies; D002415:Cats; D015331:Cohort Studies; D004217:Distemper Virus, Canine / Q000302:isolation & purification*; D004285:Dogs; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000209:etiology* / Q000821:virology; D011795:Surveys and Questionnaires
chemical_list: D000914:Antibodies, Viral