title: Elemental analysis of femoral bone from patients with fractured neck of femur or osteoarthrosis.
abstract: The elemental composition of bone has been determined by inductively coupled atomic emission and mass spectrometry to test the hypothesis that changes in major or minor elemental concentrations may contribute to the risk of fracture. Femoral bone was obtained from patients at operation for the treatment of fracture and compared with that of patients with osteoarthrosis and a necropsy control group. The data suggest that there are no major differences in bone elemental composition in patients with fractures compared with the control group. Bone adjacent to joints with osteoarthrosis tends to be less mineralized (per unit trabecular bone volume) than control bone and bone from fracture patients, and has significantly lower concentrations of boron, lead and, zinc. These observations may reflect the more rapid turnover of bone close to the arthritic joint.
authors.affiliation: Department of Pathology, University of Liverpool, UK.
authors.forename: T R
authors.initials: TR
authors.lastname: Helliwell
authors.forename: S A
authors.initials: SA
authors.lastname: Kelly
authors.forename: H P
authors.initials: HP
authors.lastname: Walsh
authors.forename: L
authors.initials: L
authors.lastname: Klenerman
authors.forename: J
authors.initials: J
authors.lastname: Haines
authors.forename: R
authors.initials: R
authors.lastname: Clark
authors.forename: N B
authors.initials: NB
authors.lastname: Roberts
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001842:Bone and Bones / Q000737:chemistry*; D005260:Female; D005265:Femoral Neck Fractures / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D013058:Mass Spectrometry / Q000379:methods*; D008875:Middle Aged; D010003:Osteoarthritis / Q000378:metabolism / Q000473:pathology*; D012680:Sensitivity and Specificity; D014131:Trace Elements / Q000032:analysis*
chemical_list: D014131:Trace Elements