Seasonal variation in platelet [3H]paroxetine binding in healthy volunteers. Relationship to climatic variables.
Recently, our laboratory has reported significant seasonal differences in [3H]paroxetine binding to platelets in depressed subjects. This study aimed to examine the seasonal variation in [3H]paroxetine binding to platelets and the relationships between [3H]paroxetine binding and climatic variables in healthy volunteers. We took monthly blood samples during one calendar year from 26 healthy volunteers for assay of [3H]paroxetine binding and analyzed the data by means of univariate and multivariate spectral and cosinor analyses. There was a statistically highly significant seasonal pattern in [3H]paroxetine binding to platelets with significant annual, 4-monthly, and bimonthly rhythms, which were expressed as a group phenomenon. [3H]Paroxetine binding to platelets was significantly lower in fall and summer than in winter and spring; lows occurred in summer and peaks in spring. The peak-trough difference in this yearly variation, expressed as a percentage of the mean, was as large as 83.7%. A large part of the variance, that is, 32.5%, in [3H]paroxetine binding could be explained by weather variables, such as ambient temperature, relative humidity, and air pressure. Highly significant common annual rhythms were expressed in [3H]paroxetine binding and ambient temperature or humidity (both inversely related) and changes in temperature the 2 weeks preceding blood samplings (positively related).
D'Hondt
P
P
Department of Psychiatry, University Hospital of Antwerp (UZA), Edegem, Belgium.
Maes
M
M
Leysen
J E
JE
Gommeren
W
W
Heylen
L
L
DeMeyer
F
F
Scharpe
S
S
Peeters
D
D
Desnyder
R
R
D000328:Adult; D000399:Air Pressure; D018687:Antidepressive Agents, Second-Generation / Q000097:blood* / Q000493:pharmacokinetics; D001792:Blood Platelets / Q000378:metabolism*; D002980:Climate; D005260:Female; D006801:Humans; D006813:Humidity; D008297:Male; D015999:Multivariate Analysis; D017374:Paroxetine / Q000097:blood* / Q000493:pharmacokinetics; D012016:Reference Values; D012044:Regression Analysis; D012621:Seasons; D013696:Temperature
D018687:Antidepressive Agents, Second-Generation; D017374:Paroxetine