Depudecin, a microbial metabolite containing two epoxide groups, exhibits anti-angiogenic activity in vivo.
Depudecin, a microbial metabolite containing two epoxide groups, was tested for its anti-angiogenic activity in an in vivo assay system involving the chorioallantoic membrane of growing chick embryo. The microbial metabolite inhibited embryonic angiogenesis in a dose-dependent manner with an ID50 of 320 ng (1.5 nmol) per egg. It also affected the growth of vascular endothelial cells, a key event in the process of angiogenesis in vivo. These results suggest that depudecin could be promising as an anti-angiogenic agent and that its anti-angiogenic action involves an inhibitory effect on vascular endothelial cell growth.
Oikawa
T
T
Department of Cancer Therapeutics, Tokyo Metropolitan Institute of Medical Science (Rinshoken), Japan.
Onozawa
C
C
Inose
M
M
Sasaki
M
M
D000466:Alkadienes / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects; D004852:Epoxy Compounds / Q000494:pharmacology*; D005233:Fatty Alcohols / Q000494:pharmacology*; D006801:Humans; D018919:Neovascularization, Physiologic / Q000187:drug effects*
D000466:Alkadienes; D004852:Epoxy Compounds; D005233:Fatty Alcohols; C072251:depudecin