Inorganic fluoride concentration after long-term sedation with isoflurane.
We report on five patients in whom long-term sedation with isoflurane for up to 7 days was used successfully. Serum inorganic fluoride concentrations were measured daily. The concentrations ranged from 12 mmol l-1 to 29 mmol l-1. These were well below the described renal toxic level of 50 mmol l-1. There was no deterioration in renal function attributable to the use of isoflurane.
Osborne
M A
MA
Intensive Care Unit, Withington Hospital, Manchester, UK.
Eddleston
J M
JM
McNicoll
W
W
D000328:Adult; D016292:Procedural Sedation / Q000009:adverse effects / Q000379:methods; D016903:Drug Monitoring; D005459:Fluorides / Q000097:blood*; D006801:Humans; D007530:Isoflurane / Q000627:therapeutic use*; D007677:Kidney Function Tests; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D013997:Time Factors
D007530:Isoflurane; D005459:Fluorides