title: Tissue characterization of intracranial tumors by magnetization transfer and spin-lattice relaxation parameters in vivo.
abstract: T1s and magnetization transfer (MT) parameters of 36 intracranial tumors were determined in vivo at 0.1 T to assess their use in tissue characterization. The mobile water relaxation times (T1w) did not differ between tumor groups, whereas the T1s, the apparent MT relaxation times (T1a), and the parameters MT contrast (MTC) differed significantly between several tumor types. The MT rates (Rwm) demonstrated the most significant differences; Rwm values could reliably separate high grade and low grade gliomas. T1ws of the tumors were commonly in the same range as that of normal gray matter, whereas other parameters differed from those of normal brain. The results indicate that MT rates are superior to other parameters in the characterization of intracranial tumors and may be also useful clinically in the grading of gliomas.
authors.affiliation: Department of Diagnostic Radiology, Turku University Hospital, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Kurki
authors.forename: N
authors.initials: N
authors.lastname: Lundbom
authors.forename: M
authors.initials: M
authors.lastname: Komu
authors.forename: M
authors.initials: M
authors.lastname: Kormano
mesh_terms: D000236:Adenoma / Q000175:diagnosis; D000704:Analysis of Variance; D001921:Brain / Q000033:anatomy & histology; D001932:Brain Neoplasms / Q000175:diagnosis*; D003287:Contrast Media; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods; D005682:Gadolinium; D005910:Glioma / Q000175:diagnosis; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D046911:Macromolecular Substances; D008279:Magnetic Resonance Imaging / Q000379:methods; D008579:Meningioma / Q000175:diagnosis; D009464:Neuroma, Acoustic / Q000175:diagnosis; D010911:Pituitary Neoplasms / Q000175:diagnosis; D015203:Reproducibility of Results; D014867:Water
chemical_list: D003287:Contrast Media; D046911:Macromolecular Substances; D014867:Water; D005682:Gadolinium