title: Transgenic mouse model for the fragile X syndrome.
abstract: Transgenic fragile X knockout mice have been constructed to provide an animal model to study the physiologic function of the fragile X gene (FMR1) and to gain more insight into the clinical phenotype caused by the absence of the fragile X protein. Initial experiments suggested that the knockout mice show macroorchidism and cognitive and behavioral deficits, abnormalities comparable to those of human fragile X patients. In the present study, we have extended our experiments, and conclude that the Fmr1 knockout mouse is a reliable transgenic model to study the fragile X syndrome.
authors.affiliation: Department of Medical Genetics, University of Antwerp, Belgium.
authors.forename: R F
authors.initials: RF
authors.lastname: Kooy
authors.forename: R
authors.initials: R
authors.lastname: D'Hooge
authors.forename: E
authors.initials: E
authors.lastname: Reyniers
authors.forename: C E
authors.initials: CE
authors.lastname: Bakker
authors.forename: G
authors.initials: G
authors.lastname: Nagels
authors.forename: K
authors.initials: K
authors.lastname: De Boulle
authors.forename: K
authors.initials: K
authors.lastname: Storm
authors.forename: G
authors.initials: G
authors.lastname: Clincke
authors.forename: P P
authors.initials: PP
authors.lastname: De Deyn
authors.forename: B A
authors.initials: BA
authors.lastname: Oostra
authors.forename: P J
authors.initials: PJ
authors.lastname: Willems
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D051860:Fragile X Messenger Ribonucleoprotein 1; D005600:Fragile X Syndrome / Q000235:genetics* / Q000503:physiopathology* / Q000523:psychology; D006801:Humans; D008297:Male; D018782:Maze Learning; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000502:physiology; D009929:Organ Size; D016601:RNA-Binding Proteins; D012016:Reference Values; D013737:Testis / Q000254:growth & development
chemical_list: D051860:Fragile X Messenger Ribonucleoprotein 1; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins; C497683:FMR1 protein, human; C497684:Fmr1 protein, mouse