[The antihypoxic action of the preparation Neoton in complicated spinal trauma].
The spinal cord tissue respiration was studied on the basis of values for oxygen tension in cerebrospinal fluid, obtained from cathode polarography. Platinum open-type pin electrode was used as a working electrode, and standard silver-silver chloride type 78L-IM electrode as a reference electrode. The Lp--0.9 polarograph connected with the H-3021 recorder was used in the study. Complicated injury of the vertebral column leads to profound hypoxia of the spinal cord manifested by decrease in the level of intracellular oxygen consumption. Use of the antihypoxic preparation "Neoton" helps to normalize the spinal cord tissue respiration, Efficacy of the use of the antihypoxant "Neoton" is dependent upon the baseline degree of impairement of the spinal cord tissue respiration, which fact should be considered in prescribing antihypoxic drugs having protective effects. Extracorporeal determination of oxygen tension in cerebrospinal fluid can be recommended as method of investigation of oxygen balance of the spinal cord in its ischemic affections.
Stashkevich
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D015687:Cell Hypoxia / Q000187:drug effects; D004341:Drug Evaluation; D006801:Humans; D010100:Oxygen / Q000134:cerebrospinal fluid; D010101:Oxygen Consumption / Q000187:drug effects; D010313:Partial Pressure; D010725:Phosphocreatine / Q000627:therapeutic use*; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism; D013124:Spinal Injuries / Q000150:complications* / Q000188:drug therapy* / Q000378:metabolism
D010725:Phosphocreatine; D010100:Oxygen