Prenatal diagnosis of a stable de novo centric fission: a case report.
We report on the prenatal diagnosis of a baby with a de novo centromeric fission of chromosome 21. Both fission products were mitotically stable. Follow-up chromosome analysis after birth confirmed the centromere fission. This chromosome fission appears to be without clinical significance for this patient.
Bogart
M H
MH
Mid-Pacific Genetics, Honolulu, HI 96814, USA.
Fujita
N
N
Serles
L
L
Hsia
Y E
YE
D002503:Centromere; D002869:Chromosome Aberrations; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D011247:Pregnancy; D011296:Prenatal Diagnosis