title: Apolipoprotein E genotypes and risk of diabetic nephropathy.
abstract: Genetic susceptibility contributes to the development of diabetic nephropathy. In considering potentially important genetic factors, this study examined the association between genetic polymorphisms in apolipoprotein (apo) E and diabetic nephropathy in 146 patients with insulin-dependent diabetes mellitus (IDDM) of 15 to 21 years' duration. Using a case-control study design, patients with proteinuria (N = 41) (albumin excretion rate (AER) > or = 250 micrograms/min) and patients with microalbuminuria (N = 31) (AER 20 to 250 micrograms/min) were compared with patients who had normoalbuminuria (N = 74) (AER < 20 micrograms/min). Genetic polymorphisms at the apo E locus were identified by the method of denaturing gradient-gel electrophoresis. There was no significant difference in allele frequencies in the proteinuric, microalbuminuric, or normoalbuminuric groups (e2 7.3%, 9.7%, 9.5%; e3 78.1%, 72.6%, 68.2%; e4 14.6%, 17.7%, 22.3%; respectively). The distribution of the apo E genotypes among the three groups of patients was also similar. These results suggest that apo E genotypes are not associated with the development of early or advanced diabetic nephropathy in patients with IDDM.
authors.affiliation: Epidemiology and Genetics Section, Joslin Diabetes Center, Boston, MA 02215, USA.
authors.forename: T
authors.initials: T
authors.lastname: Onuma
authors.forename: L M
authors.initials: LM
authors.lastname: Laffel
authors.forename: M C
authors.initials: MC
authors.lastname: Angelico
authors.forename: A S
authors.initials: AS
authors.lastname: Krolewski
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000097:blood / Q000209:etiology; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D002784:Cholesterol / Q000097:blood; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000235:genetics; D003928:Diabetic Nephropathies / Q000097:blood / Q000150:complications / Q000453:epidemiology* / Q000235:genetics; D004198:Disease Susceptibility; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011507:Proteinuria / Q000097:blood / Q000209:etiology; D012306:Risk; D014280:Triglycerides / Q000097:blood
chemical_list: D001057:Apolipoproteins E; D014280:Triglycerides; D002784:Cholesterol