Bretazenil modulates sleep EEG and nocturnal hormone secretion in normal men.
Preclinical data suggest that the imidazodiazepinone derivative bretazenil (Ro 16-6028) has anxiolytic and anticonvulsant properties with only weak sedative effects. We examined the influence of oral administration of 1 mg bretazenil on the sleep EEG and the concomitant nocturnal secretion of cortisol, growth hormone and prolactin in ten healthy young men. After bretazenil we found a significant increase in stage 2 sleep and a significant reduction in stage 3 sleep. REM latency was prolonged. Spectral analysis of sleep-EEG power revealed a decrease in delta and in theta power and an increase in sigma power. We found no significant influence on sleep onset latency or on intermittent wakefulness. Bretazenil prompted a significant decrease in cortisol secretion and a significant increase in prolactin release. It had no major influence on growth hormone secretion.
Guldner
J
J
Department of Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
Trachsel
L
L
Kratschmayr
C
C
Rothe
B
B
Holsboer
F
F
Steiger
A
A
D000328:Adult; D000927:Anticonvulsants / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000494:pharmacology*; D004569:Electroencephalography / Q000187:drug effects*; D013006:Growth Hormone / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D011388:Prolactin / Q000097:blood; D012890:Sleep / Q000187:drug effects* / Q000502:physiology
D000927:Anticonvulsants; D001570:Benzodiazepinones; D006728:Hormones; D011388:Prolactin; D013006:Growth Hormone; C054626:bretazenil; D006854:Hydrocortisone