title: Acute gastrointestinal bleeding due to Meckel's diverticulum heterotopic gastric mucosa.
abstract: Meckel's diverticulum is the most common congenital anomaly of the gastrointestinal tract occurring in approximately 2% of the population. In our retrospective study, we analyzed 58 surgical specimens of Meckel's diverticulum operated on in our hospital. Heterotopic gastric mucosa was found in ten. Aim of this study was to establish the aetiopathogenesis of inflammation and consequent haemorrhage in Meckel's diverticulum with heterotopic gastric mucosa. Some studies showed that Helicobacter-like bacteria could play an important role in determining local phlogosis in heterotopic gastric mucosa of Meckel's diverticulum, however, none were found in our biopsy specimens. Analyzing patients with acute intestinal haemorrhage (4 out of 10 with heterotopic gastric mucosa) in Meckel's diverticulum a history of previous oral administration of NSAID's was positive in 3 of them. Although in the recent literature there were few case reports on the use of NSAID's and bleeding from Meckel's diverticulum, our results suggest that even short-term use, in small quantities, of NSAID's can play an important role in determining acute bleeding from Meckel's diverticulum with heterotopic gastric mucosa.
authors.affiliation: Reparto di Gastroenterologia, Ospedale Civile Udine, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Maieron
authors.forename: D
authors.initials: D
authors.lastname: Stimac
authors.forename: C
authors.initials: C
authors.lastname: Avellini
authors.forename: L
authors.initials: L
authors.lastname: Zoratti
authors.forename: C
authors.initials: C
authors.lastname: Rizzi
authors.forename: C
authors.initials: C
authors.lastname: Scott
authors.forename: M
authors.initials: M
authors.lastname: Rubinić
authors.forename: C A
authors.initials: CA
authors.lastname: Beltrami
authors.forename: G L
authors.initials: GL
authors.lastname: Da Broi
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D002828:Choristoma / Q000150:complications*; D005260:Female; D005753:Gastric Mucosa; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000209:etiology*; D006801:Humans; D008297:Male; D008467:Meckel Diverticulum / Q000150:complications*; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal