title: Pulmonary blood flow profiles with reduced right ventricular function in lambs.
abstract: The determinants of right ventricular (RV) performance with damaged RV free wall, such as occurs with RV infarction, are still unclear. Using 20-MHz Doppler ultrasound equipment, we investigated the changes in pulmonary blood flow velocity profiles before and after ligation of the right coronary artery. RV dp/dt, stroke volume, RV stroke work, aortic pressure and cardiac output decreased and central venous pressure rose after the ligation. The RV stroke work-end-diastolic pressure relationship indicated impaired RV function following ligation. We observed shortened acceleration time (65.0 +/- 15.1 vs 54.4 +/- 6.2 ms, P < 0.05) and reduced maximum velocity of forward flow (59.0 +/- 5.9 vs 52.5 +/- 7.6 cm/s, P < 0.05) after the ligation. Acceleration was interrupted earlier after ligation than before ligation. These alterations in flow are thought to be a consequence of the altered movement of the RV free wall and ventricular septum induced by RV infarction.
authors.affiliation: Department of Pediatrics, Osaka Medical College, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Katayama
authors.forename: G W
authors.initials: GW
authors.lastname: Henry
authors.forename: R
authors.initials: R
authors.lastname: Krzeski
authors.forename: C L
authors.initials: CL
authors.lastname: Lucas
authors.forename: B
authors.initials: B
authors.lastname: Ha
authors.forename: J I
authors.initials: JI
authors.lastname: Ferreiro
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D009200:Myocardial Contraction / Q000502:physiology; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011652:Pulmonary Circulation / Q000502:physiology*; D012756:Sheep; D013318:Stroke Volume / Q000502:physiology; D018608:Ultrasonography, Doppler; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging / Q000503:physiopathology*