HmGlu1d, a novel splice variant of the human type I metabotropic glutamate receptor.
A novel splice variant, hmGlu1d, of the human mGlu1 metabotropic glutamate receptor has been isolated from a human brain library. This clone is identical to human mGlu1a except that it lacks 35 nucleotides in the 3' coding sequence, which predicts a truncated protein and a novel carboxy terminus. After injection of the encoding sequence into mouse A9 fibroblasts, quisqualate and (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3R)-ACPD) elicited concentration-dependent increases in intracellular Ca2+ (pEC50 values of 6.09 and 4.33, respectively).
Laurie
D J
DJ
Preclinical Research, Sandoz Pharma AG, Basle, Switzerland.
Boddeke
H W
HW
Hiltscher
R
R
Sommer
B
B
D000595:Amino Acid Sequence; D001483:Base Sequence; D017931:DNA Primers; D018076:DNA, Complementary; D006801:Humans; D008969:Molecular Sequence Data; D012326:RNA Splicing; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
D017931:DNA Primers; D018076:DNA, Complementary; D018094:Receptors, Metabotropic Glutamate