title: Influence of external stent size on early medial and neointimal thickening in a pig model of saphenous vein bypass grafting.
abstract: BACKGROUND
  Late saphenous vein graft failure results from intimal and medial thickening due to migration and proliferation of vascular smooth muscle cells and superimposed atheroma. These changes may represent an adaptation by the vein to its insertion into the arterial system. Using a porcine model of arteriovenous bypass grafting, we recently demonstrated that supporting the graft with a nonrestrictive external Dacron velour stent significantly reduced intimal hyperplasia and total wall thickness. In the present study, we investigated the influence of different external stent sizes on graft wall dimensions and cell proliferation.
  
  
  RESULTS
  Three stent sizes were tested: mildly restrictive, nonrestrictive, and oversized (5, 6, and 8 mm in diameter, respectively). Four weeks after grafting, total wall thickness was decreased 40% by 5-mm stents (P = .02), 66% by 6-mm stents (P = .0004), and 81% by 8-mm stents (P = .02 versus unstented grafts). Neointimal thickness was reduced almost 62% by 6-mm and 72% by 8-mm stents (both P = .01) but not by 5-mm stents. As a result, the encroachment of the intima into the lumen was reduced approximately 70% by 6- or 8-mm stents (P = .02 and P = .01 versus unstented grafts, respectively). Both neointimal and medial cell proliferation were significantly reduced by all three stents compared with unstented grafts.
  
  
  CONCLUSIONS
  External stenting of saphenous vein bypass grafts reduces early intimal and medial hyperplasia. Oversized stents give equally profound suppression of intimal thickening, obviating the need for precise size matching with the graft and greatly simplifying the surgical procedure.
authors.affiliation: Bristol Heart Institute, University of Bristol, UK.
authors.forename: M B
authors.initials: MB
authors.lastname: Izzat
authors.forename: D
authors.initials: D
authors.lastname: Mehta
authors.forename: A J
authors.initials: AJ
authors.lastname: Bryan
authors.forename: B
authors.initials: B
authors.lastname: Reeves
authors.forename: A C
authors.initials: AC
authors.lastname: Newby
authors.forename: G D
authors.initials: GD
authors.lastname: Angelini
mesh_terms: D000818:Animals; D002339:Carotid Arteries / Q000601:surgery*; D002455:Cell Division; D002548:Cerebral Revascularization; D004867:Equipment Design; D007150:Immunohistochemistry; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D012501:Saphenous Vein / Q000378:metabolism / Q000473:pathology / Q000637:transplantation*; D015607:Stents; D013552:Swine; D017539:Tunica Intima / Q000473:pathology*; D017540:Tunica Media / Q000473:pathology*
chemical_list: D018809:Proliferating Cell Nuclear Antigen