Strip test for the quick detection of increased concentrations of prostate-specific antigen in blood.
We tested the performance of the new immunochemical membrane test BioSign PSA for detecting serum concentrations of prostate-specific antigen > 4 micrograms/l. Measurements were simultaneously performed on 161 serum samples, using the strip test and three quantitative assays of prostate specific antigen (Tandem-E, IMx, LIA-mat). Based on the upper reference limit of 4 micrograms/l, 11-37% of the results obtained with the BioSign test were false-negative and 4-15% were false-positive, compared with the data of the three quantitative assays. It is concluded that the BioSign test in its present form does not satisfactorily differentiate between prostate-specific antigen concentrations above and below 4 micrograms/l, but an improved version of the test would be useful.
Lein
M
M
Klinik für Urologie, Universitätsklinikum Charité, Humboldt Universität zu Berlin, Germany.
Jung
K
K
Schnorr
D
D
Henke
W
W
Loening
S A
SA
D000328:Adult; D005188:False Negative Reactions; D005189:False Positive Reactions; D006801:Humans; D008297:Male; D017430:Prostate-Specific Antigen / Q000097:blood*; D011933:Reagent Kits, Diagnostic; D011934:Reagent Strips; D012016:Reference Values
D011933:Reagent Kits, Diagnostic; D011934:Reagent Strips; D017430:Prostate-Specific Antigen