[Responses to triple viral and tetanus vaccination in HIV-infected children].
Our objective was to study the antibody response to the parotiditis, rubella, measles and tetanus vaccines in HIV infected children. Forty-four children of HIV positive mothers, of which 14 were infected (SG) and 33 HIV negative (CG) were studied when they were between 2 and 3 years of age. Their response to vaccinations of four doses of tetanus toxoid and one dose of measles, rubella and parotiditis vaccines was assessed. Children in the SG were tested at the age of 5-6 years to study the evolution of the response. At the age of 2-3 years, all children had optimal protection against tetanus toxoid. The response to measles, parotiditis and rubella was poor (adequate levels of antibodies in 50%, 25% and 21%, respectively) in infected children and good (93%, 75% and 90%, respectively) in the CG. At 5-6 years of age, a decreased level of antitetanus antibodies were found in the SG, maintaining low protection levels. There was no evidence of any changes in the response to measles, while the number of cases with a good response to parotiditis and rubella increased. Further results are necessary to know the effectiveness of the booster. We conclude that: 1) The immunological response to vaccination is poor in HIV infected children. 2) There was no evidence of side effects or changes in the HIV symptoms after vaccination.
Echeverría Lecuona
J
J
Servicio de Pediatría, Hospital Aránzazu, San Sebastián.
Aldamiz-Echevarría Azuara
L
L
Cilla Eguiluz
G
G
Pérez Trallero
E
E
D000907:Antibodies, Bacterial / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003017:Clostridium tetani / Q000276:immunology; D015658:HIV Infections / Q000276:immunology* / Q000635:transmission; D015497:HIV-1; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008458:Measles Vaccine / Q000276:immunology*; D008459:Measles virus / Q000276:immunology; D009108:Mumps Vaccine / Q000276:immunology*; D009109:Mumps virus / Q000276:immunology; D012411:Rubella Vaccine / Q000276:immunology*; D012412:Rubella virus / Q000276:immunology; D013745:Tetanus Toxoid / Q000276:immunology*; D017778:Vaccines, Combined / Q000276:immunology
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D008458:Measles Vaccine; D009108:Mumps Vaccine; D012411:Rubella Vaccine; D013745:Tetanus Toxoid; D017778:Vaccines, Combined