GABAB receptor antagonist CGP 35348 shortens transcallosal response latency of pyramidal tract neurons.
The effects of a specific GABAB receptor antagonist, p-(3-aminopropyl)-p-diethoxymethyl-phosphonic acid (CGP 35348), on pyramidal tract neuron responses to transcallosal stimulation were investigated in the cat motor cortex in vivo. Iontophoretic application of CGP 35348 significantly increased the number of spikes from 10.3 +/- 4.4 (control; n = 27; mean +/- S.D.) to 16.7 +/- 7.2 (CGP 35348) for 20 transcallosal stimulation trials, while the latency of neuronal activity was significantly shortened from 4.4 +/- 2.1 ms (control; n = 27; mean +/- S.D.) to 3.8 +/- 1.7 ms (CGP 35348). In conclusion, CGP 35348 facilitated transcallosal synaptic transmission between pyramidal tract neurons by removal of GABAB inhibition.
Chowdhury
S A
SA
Institute of Equilibrium Research, Gifu University School of Medicine, Japan.
Kawashima
T
T
Konishi
T
T
Niwa
M
M
Matsunami
K
K
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002415:Cats; D018756:GABA Antagonists / Q000494:pharmacology*; D058788:GABA-B Receptor Antagonists; D009044:Motor Cortex / Q000187:drug effects* / Q000502:physiology; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects
D018756:GABA Antagonists; D058788:GABA-B Receptor Antagonists; D009943:Organophosphorus Compounds; C066430:CGP 35348