Regulation of renin synthesis in the juxtaglomerular cells.
Renin synthesis in vivo is feedback regulated by the plasma angiotensin II concentration, the intrarenal pressure, the salt loading of the organism and the macula densa mechanism. At the level of renal juxtaglomerular cells renin synthesis is regulated by cyclic AMP, by nitric oxide and by the cytosolic calcium concentration. Cyclic AMP and nitric oxide are stimulators, whereas calcium is an inhibitor of renin synthesis.
Della Bruna
R
R
Department of Physiology, University of Regensburg, Germany.
Kurtz
A
A
Schricker
K
K
D000818:Animals; D015870:Gene Expression; D006801:Humans; D007606:Juxtaglomerular Apparatus / Q000166:cytology / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D012083:Renin / Q000096:biosynthesis* / Q000235:genetics
D012333:RNA, Messenger; D012083:Renin