title: Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion.
abstract: We report a case of a 44-year-old woman who developed Fanconi's syndrome in association with the oral ingestion of L-lysine. L-lysine is widely available in health food stores and has been recommended in the lay press for the treatment and prevention of recurrent herpes simplex. The development of a severe tubulointerstitial nephritis, and eventual progression to chronic renal failure, underscores the importance of this entity, heretofore unrecognized in humans.
authors.affiliation: Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Lo
authors.forename: G M
authors.initials: GM
authors.lastname: Chertow
authors.forename: H
authors.initials: H
authors.lastname: Rennke
authors.forename: J L
authors.initials: JL
authors.lastname: Seifter
mesh_terms: D000328:Adult; D005198:Fanconi Syndrome / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006561:Herpes Simplex / Q000517:prevention & control; D006801:Humans; D007668:Kidney / Q000648:ultrastructure; D008239:Lysine / Q000506:poisoning* / Q000627:therapeutic use; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology
chemical_list: D008239:Lysine