Differential regulation of the mcb and emr operons of Escherichia coli: role of mcb in multidrug resistance.
The mcb operon (which is responsible for microcin B17 production) and the emr operon (which encodes a multidrug resistance pump) share a common negative regulator, EmrR. Nevertheless, compounds that induce the emr operon repress the mcb operon. The pump dedicated to microcin B17 extrusion can also protect the calls against sparfloxacin and other toxic compounds.
Lomovskaya
O
O
Department of Microbiology and Immunology, School of Medicine, Stanford University, California 94305, USA.
Kawai
F
F
Matin
A
A
D002258:Carbonyl Cyanide m-Chlorophenyl Hydrazone / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial; D009876:Operon / Q000235:genetics*
D002258:Carbonyl Cyanide m-Chlorophenyl Hydrazone