S-methylation in Parkinson's disease.
We report thiolmethyltransferase (TMT) activity in RBC membrane preparations from patients with Parkinson's disease (PD), normal controls, and patients with symptomatic parkinsonism. Unlike previous reports, our report found no significant decrease in TMT activity in PD patients compared with normal controls. Low S-methylation capacity does not appear to be a risk factor for PD in Japanese patients.
Nakagawa-Hattori
Y
Y
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Hattori
T
T
Kondo
T
T
Mizuno
Y
Y
D000368:Aged; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008745:Methylation; D008780:Methyltransferases / Q000097:blood*; D008875:Middle Aged; D010300:Parkinson Disease / Q000378:metabolism*; D010302:Parkinson Disease, Secondary / Q000378:metabolism; D012016:Reference Values; D013438:Sulfhydryl Compounds / Q000378:metabolism
D013438:Sulfhydryl Compounds; D008780:Methyltransferases; C022742:thiol S-methyltransferase