Placental tyrosine transport and maternal phenylketonuria.
Brush border and basal plasma membrane vesicles prepared from normal human placental syncytiotrophoblast have been used to study L-tyrosine transport across placenta in an attempt to investigate the aetiology of the fetal damage found in maternal phenylketonuria. The results suggest that competition for transport with a grossly raised L-phenylalanine concentration at the basal surface of the trophoblast is responsible for the suppressed delivery of L-tyrosine to the fetus across the placenta.
Kudo
Y
Y
Department of Human Anatomy, University of Oxford, UK.
Boyd
C A
CA
D002462:Cell Membrane / Q000502:physiology; D046508:Culture Techniques; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D008871:Microvilli / Q000502:physiology; D010649:Phenylalanine / Q000097:blood*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D014327:Trophoblasts / Q000502:physiology; D014443:Tyrosine / Q000097:blood*
D014443:Tyrosine; D010649:Phenylalanine