[Hemophagocytosis in a child with paroxysmal cold hemoglobinuria].
A 2-year and 5-month-old boy was admitted to Okaya municipal hospital because of low grade fever and reddish-brown urine soon after an outside walk in November, 1994. Direct Coombs test was negative, but indirect Coombs test positive. Both sugar water test and Ham test were negative. A diagnosis of paroxysmal cold hemoglobinuria (PCH) was made by Donath-Landsteiner (D-L) test which showed the presence of a high amount of anti-P specific IgG and IgM of D-L antibody. Serological tests for syphilis were negative. Cold agglutinin titer and mycoplasma antibody titer was X 128 and X 80, respectively. A bone marrow specimen exhibited pronounced hemophagocytosis. Serum INF-gamma and M-CSF level were normal (less than 5 pg/ml and 1007 units/ml, respectively). These results suggest that hemophagocytosis in this case is not due to hemophagocytic syndrome.
Takeda
M
M
Department of Pediatrics, Okaya Municipal Hospital.
Koike
K
K
Yoshie
H
H
Hasegawa
Y
Y
Ogata
H
H
Komiyama
A
A
D001853:Bone Marrow / Q000276:immunology*; D001854:Bone Marrow Cells; D002675:Child, Preschool; D016207:Cytokines / Q000097:blood; D006457:Hemoglobinuria, Paroxysmal / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007159:Immunologic Tests; D008297:Male; D010587:Phagocytosis
D016207:Cytokines; D007074:Immunoglobulin G; D007075:Immunoglobulin M