Synthesis and properties of 5-fluorouracil oligonucleotides.
Oligonucleotides of 5-fluoro-2'-deoxyuridine (FUdR) 1 and 5-fluorouridine (FUR) 2 have been prepared by the standard phosphoramidite method. Homo oligomers (24 mer) of 1, 2 and hetero oligomers of those will be described.
Koga
M
M
Department of Applied Chemistry, Faculty of Engineering, Ehime University, Matsuyama, Japan.
Yasusa
T
T
Yamamoto
M
M
Haba
S
S
Suzuki
T
T
Saeki
T
T
Ozaki
S
S
D000964:Antimetabolites, Antineoplastic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005467:Floxuridine / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014529:Uridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D000964:Antimetabolites, Antineoplastic; D009841:Oligonucleotides; D005467:Floxuridine; C001943:5-fluorouridine; D014529:Uridine