Dose-related growth deficits in LS but not SS mice prenatally exposed to alcohol.
Genetically based alcohol sensitivity may influence the severity of alcohol-related birth defects. To examine this question, measures of growth and survival were examined in offspring of the alcohol sensitive Long-Sleep (LS) and alcohol-resistant Short-Sleep (SS) mouse lines following prenatal ethanol exposure. Pregnant LS and SS mice received an ethanol dose of either 6 or 8 g/kg/day from days 7 through 18 of pregnancy. Control groups received a maltose-dextran solution made isocaloric to the 8 g/kg/day dose. Ethanol and maltose-dextrin solutions were administered as split doses, 6 h apart, via gavage. Nonintubated lab chow control groups were also included for both mouse lines. Offspring were fostered at birth to lactating mice of an outbred stock. Pregnancy was longer for ethanol-treated LS dams compared to maltose-dextrin and lab chow LS control groups, whereas pregnancy length for ethanol-treated SS dams was similar to SS controls. Prenatal ethanol exposure resulted in dose-related growth deficits in LS but not in SS litters. Line differences in postnatal growth deficits in response to prenatal alcohol exposure suggest maternal or fetal alcohol sensitivity influence alcohol-related birth defects.
Gilliam
D M
DM
Department of Psychology, University of Northern Colorado, Greeley 80639, USA.
Kotch
L E
LE
D000014:Abnormalities, Drug-Induced; D000818:Animals; D001724:Birth Weight; D003911:Dextrans / Q000494:pharmacology; D004361:Drug Tolerance; D010064:Embryo Implantation; D000431:Ethanol / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D005865:Gestational Age; D008098:Litter Size; D008320:Maltose / Q000494:pharmacology; D051379:Mice; D008817:Mice, Mutant Strains; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012890:Sleep; D015430:Weight Gain
D003911:Dextrans; D000431:Ethanol; D008320:Maltose