Quantitative phenotype analysis for localization and identification of disease-related genes in a complex genetic background.
Results from genetic investigations of blood pressure and other variables in inbred rodent models are reviewed here to illustrate the power of quantitative approaches for the detection of linkage and the ultimate identification of the underlying genes. Different studies-involving angiotensinogen and hypertension, angiotensin I-converting enzyme and cardiovascular diseases, and other traits-are used to illustrate the possibility of similar approaches to multifactorial disorders in humans.
Lathrop
G M
GM
Wellcome Trust Centre for Human Genetics, University of Oxford, UK.
D000818:Animals; D002874:Chromosome Mapping; D004195:Disease Models, Animal; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D010641:Phenotype