Prognostic value of creatine kinase BB isoenzyme in epithelial ovarian carcinoma.
Creatine kinase BB isoenzyme (CK-BB) is overexpressed in many tumor tissues, including ovarian cancer. Using a highly sensitive and specific immunofluorometric method, CK-BB levels in 89 primary ovarian cancer cytosolic extracts have been measured and the associations between CK-BB and clinicopathological features of ovarian cancer have been studied. It was found that CK-BB levels are higher in endometrioid cell carcinomas. No clear association was established between CK-BB levels and patient age, menopausal status, clinical stage, histological grade or size of residual tumor. CK-BB was not associated significantly with either disease-free or overall survival of the patients. Based on these data, it was concluded that there is no prognostic value of CK-BB in ovarian cancer. Drugs that target CK-dependent energy metabolism of tumor cells may not be selective in ovarian cancer therapy.
Zarghami
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Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario.
Katsaros
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D
Yu
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H
Diamandis
E P
EP
D000328:Adult; D000367:Age Factors; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000201:enzymology* / Q000401:mortality*; D018269:Carcinoma, Endometrioid / Q000201:enzymology / Q000401:mortality; D003402:Creatine Kinase / Q000032:analysis*; D003600:Cytosol / Q000201:enzymology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008593:Menopause; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000201:enzymology* / Q000401:mortality*; D011379:Prognosis
D014408:Biomarkers, Tumor; D007527:Isoenzymes; D003402:Creatine Kinase