title: Hemispherectomy: a hemidecortication approach and review of 52 cases.
abstract: Between 1975 and 1994, 52 hemispherectomies, of which two were anatomical and 50 hemidecortications, were performed at Johns Hopkins Medical Institutions. Eighteen patients were 2 years old or less. There were three perioperative mortalities and one patient died 9 months later from causes not related to surgery. One patient developed hydrocephalus 6 years postsurgery and has been treated effectively. Seizure control and the functional status of each patient were measured as outcome variables. Forty-six (96%) of the surviving patients were seizure free or had reduced seizures as of their last follow-up examination. Twenty-one individuals (44%) were participating in age-appropriate classes or working independently, 18 were classified as semiindependent, and nine children will likely depend on a lifetime of assisted living. The relationships between the outcome variables and the patient's age at surgery, the interval to surgery, and the etiology of the disease were compared. The authors' clinical experiences strongly suggest the importance of a multidisciplinary approach to patient selection and follow-up care. Moreover, anesthetic management of infant surgery is a major component of success.
authors.affiliation: Department of Neurological Surgery, and Pediatric Epilepsy Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
authors.forename: B S
authors.initials: BS
authors.lastname: Carson
authors.forename: S P
authors.initials: SP
authors.lastname: Javedan
authors.forename: J M
authors.initials: JM
authors.lastname: Freeman
authors.forename: E P
authors.initials: EP
authors.lastname: Vining
authors.forename: A L
authors.initials: AL
authors.lastname: Zuckerberg
authors.forename: J A
authors.initials: JA
authors.lastname: Lauer
authors.forename: M
authors.initials: M
authors.lastname: Guarnieri
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011379:Prognosis; D013341:Sturge-Weber Syndrome / Q000503:physiopathology / Q000601:surgery*