[Investigations of alpha-1-antitrypsin level in blood serum of patients with melanoma of the choroid].
OBJECTIVE
To assess alpha-1-antitrypsin concentration in blood serum of patients with melanoma of the choroid.


METHODS
35 patients (14 women and 21 men) were examined. The control group comprised 12 healthy persons. Tests of alpha-1-antitrypsin level were performed using immunologicresponse produced by diagnostic antibodies with the antigen present in the studied seru. Behring Nor-Partigen platelets were used for determinations. The results were statistically analysed using Cohran-Cox test.


RESULTS
The investigations have shown, in patients with melanoma of the choroid, the level of alpha-1-antitrypsin amounts, on the average, to 296 75.5 mg/dl. In the control group, however, it was 219 50.1 mg/dl. The statistical significance was p < 0.001.


CONCLUSIONS
A considerably higher level of glycoprotein in patients with melanoma of the choroid suggests the usefulness of determining alpha-1-antitrypsinlevel on recognising neoplasms of the visual system.
Matysik
A
A
Z II Kliniki Okulistyki AM w Lublinie.
Jakubowska-Solarska
B
B
Toczołowski
J
J
D000368:Aged; D002830:Choroid Neoplasms / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000097:blood*; D008875:Middle Aged; D000515:alpha 1-Antitrypsin / Q000032:analysis*
D000515:alpha 1-Antitrypsin