Effect of postmenopausal estrogen replacement therapy on lipoproteins.
OBJECTIVE
To investigate the association between menopause and lipoproteins and the effect of hormone replacement therapy (HRT).


METHODS
Total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides were estimated in 50 postmenopausal women and 25 ovulating women who served as controls. The lipoprotein estimations were repeated after 1 year of therapy with natural estrogen-norgestrel combination.


RESULTS
More postmenopausal women than younger women had lipoprotein values in the high-risk status (P <0.001). There were no significant changes in lipoprotein levels (P >0.05) after HRT. Women with a body mass index below 26 kg/m2 had a significant reduction in their lipoprotein risk status (P <0.01).


CONCLUSIONS
There was no demonstrably clear effect of the estrogen-progestin combination on lipoprotein levels, probably because of other compounding variables such as obesity, lack of exercise and the type of progestin used.
Omu
A E
AE
Department of Obstetrics and Gynecology, Faculty of Medicine, Kuwait University, Safat.
Al-Qattan
N
N
D000328:Adult; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology; D004338:Drug Combinations; D015914:Estrogen Replacement Therapy / Q000009:adverse effects; D004967:Estrogens / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood / Q000187:drug effects*; D008875:Middle Aged; D009644:Norgestrel / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D012307:Risk Factors; D013997:Time Factors
D004338:Drug Combinations; D004967:Estrogens; D008074:Lipoproteins; D009644:Norgestrel