title: [The use of low dose midazolam for the management of spinal anesthesia].
abstract: The present study was designed to evaluate the effects of low dose midazolam (MZ) on memories and ease of management of spinal anesthesia. MZ was administered to 103 patients (ASA 1-2), of whom 50 patients were premedicated with atropine sulfate 0.5mg and pethidine hydrochloride (group P), with 53 patients receiving no premedication (group nP). A double blind randomized trial was conducted with the dose of MZ (0, 0.01, 0.02, 0.04, 0.08 mg.kg-1), and MZ was administered i.v. to patients just prior to spinal puncture. The short-term and long-term memories were impaired after administration of MZ in both groups. But the recovery from impairment of memories was more rapid in the short-term memory than in the long-term memory, suggesting that MZ impairs mainly the acquisition of memories. A dose-dependent decrease in SpO2 was observed in group P. We conclude that MZ is a useful drug to relieve anxiety of patients during surgery, but it accompanies the risk of respiratory depression.
authors.affiliation: Department of Anesthesiology, St. Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nagahama
authors.forename: S
authors.initials: S
authors.lastname: Kikuchi
authors.forename: K
authors.initials: K
authors.lastname: Shimazaki
authors.forename: T
authors.initials: T
authors.lastname: Tateda
authors.forename: T
authors.initials: T
authors.lastname: Aoki
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000775:Anesthesia, Spinal; D014151:Anti-Anxiety Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D007275:Injections, Intravenous; D008568:Memory / Q000187:drug effects; D008874:Midazolam / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D008875:Middle Aged; D011229:Preanesthetic Medication; D012120:Respiration Disorders / Q000139:chemically induced
chemical_list: D014151:Anti-Anxiety Agents; D008874:Midazolam