title: Unusual presentation of Ewing sarcoma with t(21;22) in a 3-year-old boy.
abstract: OBJECTIVE
  We describe a 3-year-old boy with widespread, metastatic Ewing sarcoma and an unusual translocation, involving chromosomes 21 and 22.
  
  
  METHODS
  Cytogenetic studies were performed on a biopsy of the primary tumor. These included GTG banding and fluorescence in situ hybridization.
  
  
  RESULTS
  A balanced translocation between chromosomes 21 and 22 was noted with translocation breakpoints at bands 21q22 and 22q12.
  
  
  CONCLUSIONS
  The t(21;22) translocation represents a new cytogenetic abnormality that may be associated with Ewing sarcoma. Its prognostic significance, if any, remains to be determined.
authors.affiliation: Department of Pediatrics, Children's Medical Center, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA.
authors.forename: G V
authors.initials: GV
authors.lastname: Massey
authors.forename: N L
authors.initials: NL
authors.lastname: Dunn
authors.forename: J L
authors.initials: JL
authors.lastname: Heckel
authors.forename: E C
authors.initials: EC
authors.lastname: Davis
authors.forename: C
authors.initials: C
authors.lastname: Jackson-Cook
authors.forename: E C
authors.initials: EC
authors.lastname: Russell
mesh_terms: D002675:Child, Preschool; D002891:Chromosomes, Human, Pair 21; D002892:Chromosomes, Human, Pair 22; D006801:Humans; D008297:Male; D012512:Sarcoma, Ewing / Q000235:genetics*; D014178:Translocation, Genetic