title: Breath-hold MR measurements of blood flow velocity in internal mammary arteries and coronary artery bypass grafts.
abstract: Breath-hold velocity-encoded cine MR (VENC-MR) imaging is a feasible method for measuring phasic blood flow velocity in small vessels that move during respiration. The purposes of the current study are to compare breathhold VENC-MR measurements of flow velocities in the internal mammary arteries (IMA) with nonbreath-hold measurements and to characterize the systolic and diastolic flow velocity curves in a cardiac cycle in native IMA and IMA grafts. Flow velocity in 30 native IMA and 8 IMA grafts were evaluated with a breath-hold VENC-MR sequence with K-space segmentation and view-sharing reconstruction (TR/TE = 16/9 msec, VENC = 100 cm/s). In 10 native IMA, nonbreath-hold VENC-MR images were acquired as well for comparison. Breath-hold VENC-MR imaging showed significantly higher systolic and diastolic peak velocities in native IMA (43.1 cm/second +/- 15.0 and 10.0 cm/second +/- 4.8), in comparison to those of nonbreath-hold VENC-MR imaging (27.6 cm/second +/- 10.2 and 7.3 cm/second +/- 3.9, P < .05). The diastolic/systolic peak velocity ratio in the IMA grafts (.88 +/- .41) was significantly higher than that in native IMA (.24 +/- .08, P < .01). Interobserver variability in the flow velocity measurement was less than 4%. Breath-hold VENC-MR imaging demonstrated higher peak flow velocity in the IMA than nonbreath-hold VENC-MR imaging. This technique is a rapid and effective method for the noninvasive assessment of blood flow velocity in IMA grafts.
authors.affiliation: Department of Radiology, University of California, San Francisco 94143-0628, USA.
authors.forename: H
authors.initials: H
authors.lastname: Sakuma
authors.forename: S
authors.initials: S
authors.lastname: Globits
authors.forename: M
authors.initials: M
authors.lastname: O'Sullivan
authors.forename: A
authors.initials: A
authors.lastname: Shimakawa
authors.forename: M A
authors.initials: MA
authors.lastname: Bernstein
authors.forename: T K
authors.initials: TK
authors.lastname: Foo
authors.forename: T M
authors.initials: TM
authors.lastname: Amidon
authors.forename: K
authors.initials: K
authors.lastname: Takeda
authors.forename: T
authors.initials: T
authors.lastname: Nakagawa
authors.forename: C B
authors.initials: CB
authors.lastname: Higgins
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D001026:Coronary Artery Bypass; D003326:Coronary Circulation; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008323:Mammary Arteries / Q000503:physiopathology* / Q000637:transplantation; D008875:Middle Aged; D015588:Observer Variation; D015203:Reproducibility of Results; D012119:Respiration