Initial cortical reactions to injury of the median and radial nerves to the hands of adult primates.
The area 3b hand cortex of adult squirrel monkeys was mapped during the first minutes to hours after transecting the radial and median nerves to the hand. The objective was to evaluate initial cortical reactions to this injury and to determine whether patterns and extents of cortical change are similar in different individuals. There are 5 main findings. First, cortical aggregates related to ulnar nerve inputs from the hand rapidly expanded to occupy an additional 21% of the cortical hand map. Second, face and forearm inputs, which normally activate areas adjacent to hand cortex, rapidly expanded into areas of 4% and 1% of the hand cortex respectively. Third, cortical changes involved shifts in receptive field locations that were initiated within minutes after injury. Fourth, the spatial patterns and extents of cortical change were similar in different individuals. Finally, the pattern of cortical change produced after this injury differed from the pattern seen after injury of the median and ulnar nerves. These rapid expansions are a beginning point from which further changes must progress; however, in contrast to changes accompanying chronic hand injuries, these initial cortical reactions do not appear dictated by use of uninjured inputs.
Silva
A C
AC
Department of Anatomy and Neurobiology, Medical College of Ohio, Toledo, USA.
Rasey
S K
SK
Wu
X
X
Wall
J T
JT
D000818:Animals; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D004292:Dominance, Cerebral / Q000502:physiology; D005145:Face / Q000294:innervation; D005542:Forearm / Q000294:innervation; D006225:Hand / Q000294:innervation*; D008475:Median Nerve / Q000293:injuries*; D009412:Nerve Fibers / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D011826:Radial Nerve / Q000293:injuries*; D012453:Saimiri / Q000502:physiology*; D014459:Ulnar Nerve / Q000502:physiology