title: Nonsteroidal antiinflammatory drug use and cognitive function in the elderly: inconclusive results from a population-based cohort study.
abstract: As part of the cohort Paquid, we studied the relationship between the use of NSAID, incidence of dementia, and evolution of cognitive functions. Dementia was diagnosed by DSM-III criteria and cognitive functions was assessed through the Mini-Mental Status Examination (MMSE). During 2 years of follow-up, the incidence rate of dementia was 3.84% among 53 NSAID users as compared with 3.77% in 1199 nonusers (OR, 0.98; 95% CI, 0.23-4.16). Using a cutoff of -3 points for the MMSE score and taking into account age and educational status in a logistic regression model, NSAID use was related to an unfavourable variation of the MMSE score (OR, 2.84; 95% CI, 0.99-8.1).
authors.affiliation: Arme-Pharmacovigilance, Centre de Pharmacovigilance, Hôpital Pellegrin, Bordeaux, France.
authors.forename: A
authors.initials: A
authors.lastname: Fourrier
authors.forename: L
authors.initials: L
authors.lastname: Letenneur
authors.forename: B
authors.initials: B
authors.lastname: Bégaud
authors.forename: J F
authors.initials: JF
authors.lastname: Dartigues
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D003072:Cognition Disorders / Q000453:epidemiology*; D015331:Cohort Studies; D003704:Dementia / Q000453:epidemiology; D006801:Humans; D007361:Intelligence Tests; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal