GyrB mutations in Staphylococcus aureus strains resistant to cyclothialidine, coumermycin, and novobiocin.
The sequence of the gyrase B subunit gene from Staphylococcus aureus strains resistant to the gyrase B subunit inhibitors cyclothialidine, coumermycin, and novobiocin has been determined. The residues altered in the resistant gyrase B subunits map to the ATP-binding region, suggesting that the drugs inhibit ATP binding and hydrolysis. The pattern of cross-resistances indicates that the detailed binding mode of the compounds differs.
Stieger
M
M
F. Hoffmann-La Roche, Basel, Switzerland.
Angehrn
P
P
Wohlgensinger
B
B
Gmünder
H
H
D049933:Aminocoumarins; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003374:Coumarins / Q000494:pharmacology; D027081:DNA Gyrase; D004250:DNA Topoisomerases, Type II / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009675:Novobiocin / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000494:pharmacology*; D012689:Sequence Homology, Nucleic Acid; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics
D049933:Aminocoumarins; D000900:Anti-Bacterial Agents; D003374:Coumarins; D010456:Peptides, Cyclic; C085889:cyclothialidine; D009675:Novobiocin; D027081:DNA Gyrase; D004250:DNA Topoisomerases, Type II; C004628:coumermycin