title: Langerhans cell histiocytosis, diabetes insipidus, hyperprolactinemia and empty sella: a four-fold association. Report of two cases.
abstract: Two cases of Langerhans cell histiocytosis (LCH) expressing as Hand-Schuller-Christian syndrome with diabetes insipidus, hyperprolactinemia and empty sella are here reported. Up-to-date this four-fold association is lacking in world literature and it is here discussed in the light if LCH is a cancer or the clinical expression of an immunologic disorder.
authors.affiliation: Settore di Immunologia ed Endocrinologia Oncologica, Ospedale A. Cardarelli, Napoli, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Panza
authors.forename: B
authors.initials: B
authors.lastname: Merola
authors.forename: A
authors.initials: A
authors.lastname: Colao
authors.forename: G
authors.initials: G
authors.lastname: Iodice
authors.forename: A
authors.initials: A
authors.lastname: de Bellis
authors.forename: A
authors.initials: A
authors.lastname: Bizzarro
authors.forename: A
authors.initials: A
authors.lastname: Bellastella
authors.forename: G
authors.initials: G
authors.lastname: Lombardi
mesh_terms: D000328:Adult; D003919:Diabetes Insipidus / Q000097:blood / Q000503:physiopathology*; D004652:Empty Sella Syndrome / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000097:blood / Q000503:physiopathology*; D006728:Hormones / Q000097:blood; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged
chemical_list: D006728:Hormones