[The brain catecholaminergic system during the long-term correction of hereditary arterial hypertension].
L-DOPA administration to 21--25-day-old rats with inherited stress-induced arterial hypertension (ISIAH rats)lowered arterial pressure both at rest and in emotional stress in adult rats. The effect seems to be due to enhancement of the brain catecholamine synthesis rather than the peripheral one in early ontogenesis. The long-term hypotensive effect of the L-DOPA was supposed to be caused in part by changes revealed in the brain catecholaminergic system.
Maslova
L N
LN
Shishkina
G T
GT
Bulygina
V V
VV
Markel'
A L
AL
Naumenko
E V
EV
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D002230:Carbidopa / Q000627:therapeutic use; D004298:Dopamine / Q000378:metabolism; D015259:Dopamine Agents / Q000627:therapeutic use; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D006973:Hypertension / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism*; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D017983:Receptors, Catecholamine / Q000187:drug effects / Q000378:metabolism*; D013997:Time Factors
D015259:Dopamine Agents; D004338:Drug Combinations; D017983:Receptors, Catecholamine; C009265:carbidopa, levodopa drug combination; D007980:Levodopa; D002230:Carbidopa; D004298:Dopamine; D009638:Norepinephrine