A new model for occluding the left coronary artery in the rabbit without thoracotomy.
A small, nonmagnetic coil was fluoroscopically guided into the left circumflex coronary artery (LCXA) at the midventricular level via the left femoral artery in seven rabbits. Coronary artery occlusion was confirmed by intracoronary contrast injection, electrocardiographic changes, akinesis of the posterolateral wall distal to the occluded area, and histopathological staining of the myocardium. This new model of a closed-chest coronary artery occlusion in the rabbit may be suitable for acute ischemic myocardium studies that do not require reperfusion.
Derugin
N
N
Department of Radiology, University of California, San Francisco 94143, USA.
Masui
T
T
Konishi
Y
Y
D000818:Animals; D003250:Constriction; D017023:Coronary Angiography; D003327:Coronary Disease; D003331:Coronary Vessels; D004195:Disease Models, Animal; D005260:Female; D011817:Rabbits; D013908:Thoracotomy