title: A mutant dihydrofolate reductase-thymidylate synthase from Leishmania major as a selectable marker in transfection experiments.
authors.affiliation: Instituto de Parasitologia y Biomedicina, Consejo Superior de Investigaciones Cientificas, Granada, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Arrebola
authors.forename: A
authors.initials: A
authors.lastname: Olmo
authors.forename: A
authors.initials: A
authors.lastname: Camacho
authors.forename: L M
authors.initials: LM
authors.lastname: Ruiz-Pérez
authors.forename: D
authors.initials: D
authors.lastname: González-Pacanowska
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance / Q000235:genetics; D005819:Genetic Markers; D018320:Leishmania major / Q000201:enzymology / Q000235:genetics*; D008727:Methotrexate / Q000494:pharmacology; D009097:Multienzyme Complexes / Q000235:genetics*; D009154:Mutation; D012641:Selection, Genetic; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics*; D013940:Thymidylate Synthase / Q000235:genetics*; D014162:Transfection / Q000379:methods*
chemical_list: D005819:Genetic Markers; D009097:Multienzyme Complexes; C056930:thymidylate synthase-dihydrofolate reductase; D013762:Tetrahydrofolate Dehydrogenase; D013940:Thymidylate Synthase; D008727:Methotrexate