Heat shock protein 72/73 in normal and diseased kidneys.
The induction of heat shock (stress) proteins (HSP) is a response by cells due to a variety of physical, chemical, and infectious agents. They have a significant role as cytoprotectants, in the regulation of cellular functions, and in the recovery after sublethal injury. Using antibody to mammalian HSP 72/73, we have performed as immunohistological study of human renal tissue in normal and diseased states, including idiopathic nephrotic syndrome, proliferative and crescentic glomerulonephritis, and interstitial nephritis. A significant increase of HSP expression was noted in certain segments of the tubule in acute interstitial nephritis and in glomerulonephritis accompanied by active interstitial inflammation. A possible role by the inflammatory mediators in the induction of HSP in those cases is suggested.
Venkataseshan
V S
VS
Mt Sinai School of Medicine, New York, N.Y., USA.
Marquet
E
E
D000911:Antibodies, Monoclonal; D003599:Cytoskeleton / Q000378:metabolism; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D007674:Kidney Diseases / Q000378:metabolism* / Q000473:pathology; D007684:Kidney Tubules / Q000166:cytology / Q000378:metabolism / Q000648:ultrastructure; D008854:Microscopy, Electron; D014746:Vimentin / Q000378:metabolism
D000911:Antibodies, Monoclonal; D018840:HSP70 Heat-Shock Proteins; D014746:Vimentin