Luminal capsaicin inhibits fluid secretion induced by enterotoxin E. coli STa, but not by carbachol, in vivo in rat small and large intestine.
The enterotoxin E. coli STa induced fluid secretion in the rat jejunum, ileum and proximal colon in vivo that was greatly inhibited by the co-presence of luminal capsaicin, which is a specific neural toxin of afferent C fibres. The same dose of capsaicin had no effect on the fluid secretion activated by carbachol in the jejunum, ileum and proximal colon. Afferent C fibres appear to be involved in the activation by STa of fluid secretion in the rat intestine in vivo.
Nzegwu
H C
HC
Faculty of Health and Social Work, Anglia Polytechnic University, Chelmsford, UK.
Levin
R J
RJ
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology*; D002712:Chlorides / Q000378:metabolism; D004768:Enterotoxins / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004926:Escherichia coli; D007419:Intestinal Secretions / Q000187:drug effects* / Q000502:physiology; D009412:Nerve Fibers / Q000187:drug effects / Q000378:metabolism; D009498:Neurotoxins / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D002712:Chlorides; D004768:Enterotoxins; D009498:Neurotoxins; D002217:Carbachol; D002211:Capsaicin