title: Role of cholecystokinin as a regulator of solid and liquid gastric emptying in humans.
abstract: The role of endogenous cholecystokinin (CCK) in the regulation of gastric emptying remains controversial. We therefore studied the effect of the CCK-A receptor antagonist loxiglumide on gastric emptying of a high-caloric solid-liquid meal in humans. Gastric emptying was assessed in eight volunteers using intravenous loxiglumide or placebo in a randomized double-blind order. Subjects were studied by a dual-headed gamma camera after ingestion of a pancake (570 kcal) labeled with 99mTc-sulfur colloid and 500 ml 10% glucose containing 111In-diethylenetriamine pentaacetic acid. Plasma CCK was measured by a specific radioimmunoassay. Loxiglumide markedly accelerated gastric emptying of both phases of the meal. The lag period was shortened by 26% (P < 0.03); the area under the emptying curve and half-emptying time of solid emptying were lowered by 19 and 24% (P < 0.02) and of liquid emptying by 18 and 24% (P < 0.04), respectively. Plasma CCK levels were higher during infusion of loxiglumide compared with placebo (P < 0.02). These data demonstrate that post-prandially released CCK is a major regulator of gastric emptying of physiological meals containing both solid and liquid components.
authors.affiliation: Department of Gastroenterology, University Hospital, Lausanne, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Borovicka
authors.forename: C
authors.initials: C
authors.lastname: Kreiss
authors.forename: K
authors.initials: K
authors.lastname: Asal
authors.forename: B
authors.initials: B
authors.lastname: Remy
authors.forename: C
authors.initials: C
authors.lastname: Mettraux
authors.forename: A
authors.initials: A
authors.lastname: Wells
authors.forename: N W
authors.initials: NW
authors.lastname: Read
authors.forename: J B
authors.initials: JB
authors.lastname: Jansen
authors.forename: M
authors.initials: M
authors.lastname: D'Amato
authors.forename: A B
authors.initials: AB
authors.lastname: Delaloye
authors.forename: M
authors.initials: M
authors.lastname: Fried
authors.forename: W
authors.initials: W
authors.lastname: Schwizer
mesh_terms: D000328:Adult; D002766:Cholecystokinin / Q000502:physiology*; D005260:Female; D005502:Food; D015902:Gamma Cameras; D005746:Gastric Emptying / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D002766:Cholecystokinin