title: Iodized-oil retention within hepatic hemangioma: characteristics on iodized-oil CT.
abstract: OBJECTIVE
  The purpose of this study was to describe the characteristic computed tomographic (CT) appearance of iodized-oil retention in hepatic hemangioma and to evaluate the duration of the retention of iodized oil on follow-up CT.
  
  
  METHODS
  Seventeen hepatic hemangiomas of 14 patients were studied with CT performed 1-3 weeks after injection of 2-9 ml of iodized oil (iodized-oil CT) for the characterization of focal hepatic lesions, which needed differential diagnosis with hepatocellular carcinoma in 10 patients, for therapy in two patients, and for chemoembolization therapy of accompanying hepatocellular carcinomas in two. Twelve patients had 1-7 follow-up CT scans within an interval of 1-38 months.
  
  
  RESULTS
  In all cases, iodized-oil CT showed iodized-oil retention within the tumor, regardless of tumor size, shape, location, and amount of injected iodized oil. The distribution was incomplete and predominantly peripheral in all cases. Central retention was also seen in seven cases, in which a relatively large amount of iodized oil was injected, but retention of iodized oil in the tumor was incomplete even in two cases in which a large amount of iodized oil was injected to relieve symptoms and in three cases in which prominent uptake of surrounding liver parenchyma was seen. Patterns of retention were predominantly spotty in five, predominantly nodular in four, and mixed in eight patients. Retention materials slowly washed out but persisted for at least 3 months and up to 38 months (mean = 18.1 months), and complete washout was not seen in any cases at follow-up CT.
  
  
  CONCLUSIONS
  In all cases of hepatic hemangiomas, iodized oil was retained, and retention persisted over several months. Distribution and patterns of retention were characteristically peripheral, spotty, and nodular at iodized-oil CT. Knowledge of the iodized-oil CT appearance of hepatic hemangioma would be helpful to interpret follow-up CT studies of patients who have undergone iodized-oil chemoembolization procedures.
authors.affiliation: Department of Diagnostic Radiology, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea.
authors.forename: W K
authors.initials: WK
authors.lastname: Moon
authors.forename: B I
authors.initials: BI
authors.lastname: Choi
authors.forename: J K
authors.initials: JK
authors.lastname: Han
authors.forename: S H
authors.initials: SH
authors.lastname: Kim
authors.forename: J W
authors.initials: JW
authors.lastname: Chung
authors.forename: J H
authors.initials: JH
authors.lastname: Park
authors.forename: M C
authors.initials: MC
authors.lastname: Han
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000378:metabolism; D016461:Chemoembolization, Therapeutic; D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006391:Hemangioma / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000628:therapy; D006801:Humans; D007275:Injections, Intravenous; D007459:Iodized Oil / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000628:therapy; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D007459:Iodized Oil