title: Influence of selective nerve fiber blocks on argon laser-induced thermal pain in the human skin.
abstract: Influence of selective nerve fiber blocks on cutaneous pain induced by short argon laser pulses was studied in healthy humans. The minimal energy per surface area needed to produce a pain sensation was lower with a larger stimulus surface indicating spatial summation. Both compression of the peripheral nerve innervating the stimulus site (A-fiber block) and prolonged topical treatment of the stimulus site with 1% capsaicin (a predominant block of nociceptive C-fibers) produced an elevation of the pain threshold. Prolonged capsaicin treatment produced significantly higher pain thresholds than the compression block. Magnitude of the pain threshold elevation induced by nerve blocks varied depending on the area of the stimulus surface. Especially following prolonged capsaicin treatment, pain threshold elevations tended to be smaller with the larger area of the stimulus surface suggesting an enhanced spatial summation effect. Tactile thresholds were significantly elevated only by the compression block. The results indicate that nociceptive C-fibers have a significant contribution to the threshold sensation of pain induced by argon laser. Moreover, following impairment of function in nociceptive C-fibers, the spatial summation of argon laser-induced pain tends to be enhanced.
authors.affiliation: Department of Dermatology, University of Helsinki Central Hospital, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Grönroos
authors.forename: T
authors.initials: T
authors.lastname: Reunala
authors.forename: A
authors.initials: A
authors.lastname: Pertovaara
mesh_terms: D000328:Adult; D002211:Capsaicin / Q000494:pharmacology; D005260:Female; D006358:Hot Temperature; D006801:Humans; D007834:Lasers; D008297:Male; D008875:Middle Aged; D009407:Nerve Block; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology*; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000502:physiology; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology; D010146:Pain / Q000503:physiopathology*; D017288:Pain Threshold / Q000187:drug effects; D012867:Skin / Q000294:innervation / Q000503:physiopathology*
chemical_list: D002211:Capsaicin