title: A study of inbreeding and kinship in intracranial aneurysms in the Saguenay Lac-Saint-Jean region (Quebec, Canada).
abstract: The genealogies of 533 individuals with an intracranial aneurysm (IA) born in the Saguenay-Lac-Saint-Jean region, a geographically isolated area located in northeastern Quebec, were reconstructed using a population-based register. A control group consisting of three individuals of the same sex and born on the same day and in the same municipality than the IA patients was created; the genealogies of the 1599 controls were also reconstructed. The coefficients of inbreeding and kinship were calculated. Familial aggregation, i.e. the presence of IA in two or more first- to third-degree relatives, was also sought. The mean inbreeding coefficient was lower in the IA group than in the control group (7.92 x 10(-4) versus 10.04 x 10(-4)). The mean kinship coefficient was higher in the IA group than in the control group (2.17 x 10(-4) versus 1.55 x 10(-4)). Forty-eight IA patients (9.0%) were first-degree relatives compared to only 1.9% of the control individuals. The proportion of individuals showing familial aggregation was higher in the IA group than in the control group (29.8% and 18.6% respectively). These results strongly suggest that some IA are genetically determined in this population.
authors.affiliation: Département des Sciences Humaines, Université du Québec à Chicoutini, Canada.
authors.forename: M
authors.initials: M
authors.lastname: De Braekeleer
authors.forename: L
authors.initials: L
authors.lastname: Pérusse
authors.forename: L
authors.initials: L
authors.lastname: Cantin
authors.forename: J M
authors.initials: JM
authors.lastname: Bouchard
authors.forename: J
authors.initials: J
authors.lastname: Mathieu
mesh_terms: D003241:Consanguinity; D005190:Family; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000235:genetics*; D008297:Male; D011792:Quebec