title: Genetic localisation of MRX27 to Xq24-26 defines another discrete gene for non-specific X-linked mental retardation.
abstract: A large family with non-specific X-linked mental retardation (MRX) was first described in 1991 [Glass et al., 1991], with a suggestion of linkage to Xq26-27. The maximum lod score was 1.60 (theta = 0.10) with the F9 locus. The localisation of this MRX gene has now been established by linkage to microsatellite markers. Peak pairwise lod scores of 4.02 and 4.01 (theta = 0.00) were attained at the DXS1114 and DXS994 loci respectively. This MRX gene is now designated MRX27 and is localised to Xq24-26 by recombination events detected by DXS424 and DXS102. This regional localisation spans 26.2 cM on the genetic background map and defines another distinct MRX interval by linkage to a specific region of the X chromosome.
authors.affiliation: Department of Cytogenetics and Molecular Genetics, Women's and Children's Hospital, Adelaide, Australia.
authors.forename: A K
authors.initials: AK
authors.lastname: Gedeon
authors.forename: I A
authors.initials: IA
authors.lastname: Glass
authors.forename: J M
authors.initials: JM
authors.lastname: Connor
authors.forename: J C
authors.initials: JC
authors.lastname: Mulley
mesh_terms: D002874:Chromosome Mapping; D005260:Female; D006580:Genetic Carrier Screening; D008040:Genetic Linkage; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D008297:Male; D010375:Pedigree; D014960:X Chromosome