[Serum levels of remnant-like particles-cholesterol (RLP-C) in patients on hemodialysis].
Serum remnant-like particles-cholesterol (RLP-C), an atherosclerosis risk factor that strongly reflects disorders of chyromicron and VLDL metabolism and contains high levels of TG, was measured in patients on hemodialysis and CAPD. The purpose of this study was to determine the serum levels of RLP-C in 30 outpatients on hemodialysis (18 males, 12 females) and 84 patients on CAPD (53 males, 31 females). The serum RLP-C level was 8.1 +/- 13 mg/dl in CAPD patients and 2.7 +/- 0.2 mg/dl in hemodialysis patients (p < 0.001). Patients who used dialysate containing over 150 g of glucose per day, showed higher levels of serum RLP-C than CAPD patients whose glucose consumption was under 150 g (10.4 +/- 2.4 mg/dl vs. 5.5 +/- 0.6 mg/dl, p < 0.01). There was no statistical relationship between age, sex, dialysis duration and serum RLP-C in CAPD and hemodialysis patients. Serum level of RLP-C was positively correlated with serum triglyceride, total cholesterol, apolipoprotein B and VLDL, and was negatively correlated with apoA-I/apoB in the dialysis patients. It appears that RLP-C, which is one of the risk factors of atherosclerosis, might reflect a disorder of triglyceride metabolism in patients on dialysis, especially on CAPD.
Hamada
C
C
Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Kubota
M
M
Yokoyama
K
K
Ishiguro
N
N
Tomino
Y
Y
D000328:Adult; D015415:Biomarkers / Q000097:blood*; D001798:Blood Proteins / Q000032:analysis; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D006435:Renal Dialysis; D014280:Triglycerides / Q000097:blood
D015415:Biomarkers; D001798:Blood Proteins; D008076:Cholesterol, HDL; D014280:Triglycerides; D002784:Cholesterol