Intracerebroventricular enterostatin stimulates food intake in non-food-deprived rats.
Previous studies reported that ICV enterostatin reduced high-fat food intake in food-deprived rats. The present study sought to determine if ICV enterostatin would decrease intake of a high-fat food in non-food-deprived rats. Eight doses (0-32 micrograms) were tested. Enterostatin (32 micrograms) significantly stimulated cookie intake at 30 min. Enterostatin did not reduce food intake at any dose. These results conflict with previous reports and suggest that central enterostatin does not play a role in suppressing, but may play a role in stimulating, high-fat food consumption in non-food-deprived rats.
Rice
H B
HB
Pennsylvania State University, Nutrition Department, University Park 16802, USA.
Corwin
R L
RL
D000818:Animals; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology; D003089:Colipases / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects* / Q000502:physiology; D004792:Enzyme Precursors; D005260:Female; D007276:Injections, Intraventricular; D011498:Protein Precursors / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D003089:Colipases; D004792:Enzyme Precursors; D011498:Protein Precursors; C037107:procolipase