title: Colour DOPPLER image analysis for tissue vascularity and perfusion: a preliminary clinical evaluation.
abstract: An automated system for measuring features of colour Doppler (CD) images has been examined for its ability to measure tissue perfusion in vivo under conditions of diffuse vascularity. Seven statistical features were extracted from CD images of human calf muscle and compared with the arterial input measured by plethysmography. It was found that, when appropriate scanning procedures are employed, good correlation is achieved with arterial input (r = 0.96 to 0.99). Ultrasound beam angle was important, even for the assessment of "colour area." A sensitive velocity scale was ideal for "percentage colour" (r = 0.979). "Mean colour velocity" correlates well with arterial input (r = 0.979) when the volocity scale was optimised for each CD scan. "Integrated colour velocity per unit area" was more responsive when using a variable velocity scale (r = 0.99) than a fixed velocity scale (r = 0.98), but was less responsive to low flow. Automated CD analysis speeds up the process of quantitative assessment of tissue vasculature and perfusion. It is therefore essential for the analysis of dynamic studies of ultrasound contrast agents and serial examinations when monitoring response to therapy.
authors.affiliation: Department of Nuclear Medicine, Institute of Cancer Research and Royal Marsden Hospital, Surrey, UK.
authors.forename: W
authors.initials: W
authors.lastname: Hirsch
authors.forename: D S
authors.initials: DS
authors.lastname: Bell
authors.forename: D C
authors.initials: DC
authors.lastname: Crawford
authors.forename: S G
authors.initials: SG
authors.lastname: Kale
authors.forename: V R
authors.initials: VR
authors.lastname: McCready
authors.forename: J C
authors.initials: JC
authors.lastname: Bamber
mesh_terms: D001158:Arteries; D001783:Blood Flow Velocity; D001808:Blood Vessels / Q000000981:diagnostic imaging* / Q000502:physiology; D003287:Contrast Media; D006801:Humans; D007091:Image Processing, Computer-Assisted; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000000981:diagnostic imaging; D005082:Physical Exertion / Q000502:physiology; D010991:Plethysmography; D012039:Regional Blood Flow; D012680:Sensitivity and Specificity; D018615:Ultrasonography, Doppler, Color / Q000379:methods
chemical_list: D003287:Contrast Media