Activity of CI-960 alone and in combination with amoxycillin against Listeria monocytogenes, and comparison with other quinolones.
In-vitro activity of CI-960 against seven strains of Listeria monocytogenes was compared to that of other fluoroquinolones. MICs/MBCs were: ciprofloxacin and sparfloxacin: 0.5-2/1-4 mg/L;PD 131628: 0.125-0.5/0.25-2 mg/L; CI-960: 0.06-0.25/0.25-0.5 mg/L. At 4 h, CI-960 (4 x MIC) reduced the inoculum (log10 cfu) by 2.88 +/- 0.61 compared with 1.78 +/- 0.48 for ciprofloxacin, 1.5 +/- 0.46 for sparfloxacin, and 1.35 +/- 0.47 for PD 131628 (P < 0.05). At 24 h, the bactericidal effects were similar (-4 log10 cfu). The amoxycillin/CI-960 (8 x MIC) combination was bactericidal, without emergence of resistant mutants.
Boisivon
A
A
Laboratoire de Microbiologie, Centre Hospitalier, Saint Germain en Laye, France.
Dhoyen
N
N
Carbon
C
C
D000658:Amoxicillin / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D004338:Drug Combinations; D024841:Fluoroquinolones; D008089:Listeria monocytogenes / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology*; D015363:Quinolones / Q000494:pharmacology*
D000890:Anti-Infective Agents; D004338:Drug Combinations; D024841:Fluoroquinolones; D010406:Penicillins; D015363:Quinolones; D000658:Amoxicillin; C057477:clinafloxacin