Inhibitory effects of indomethacin on implantation and its related phenomena.
The dose-response relationship for the inhibitory effect of indomethacin on implantation and continuance of pregnancy was examined in four groups of rabbits administered with indomethacin (2.5, 5.0, 7.5 and 10.0 mg/kg) during the implantation period and compared with a control group. Implanted fetuses and corpora lutea were counted by laparotomy, and the number of offspring born was noted. The inhibitory effect of indomethacin on implantation was found to be dose-dependent, and the birth rate decreased in the indomethacin groups compared with the control group. As a result, even where implantation had been achieved, death of the implanted fetuses occurred at a high rate in rabbits administered with indomethacin during the implantation period.
Kanayama
K
K
Department of Veterinary Physiology, College of Agriculture and Veterinary Medicine, Nihon University, Kanagawa, Japan.
Osada
H
H
Nariai
K
K
Endo
T
T
D000818:Animals; D004305:Dose-Response Relationship, Drug; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D007213:Indomethacin / Q000494:pharmacology*; D011247:Pregnancy; D011817:Rabbits
D007213:Indomethacin