title: [Skull base metastasis from renal cell carcinoma presenting as abducens nerve paresis: report of two cases].
abstract: We report two cases of skull base metastasis from renal cell carcinoma. Case 1: A 55-year-old female presented with a skull base tumor located on the clivus. Partial removal of the tumor was performed via the transsphenoidal approach. Case 2: A 44-year-old male presented with a skull base tumor occupying the orbital, nasal, and paranasal cavities. The first operation, partial removal of the tumor, was performed via the transsphenoidal approach. Thereafter, the tumor regrowth and the patient's symptoms were progressive, so a second operation was performed via Le-Forte I craniotomy to prevent cranial nerve dysfunction and air way obstruction. The initial symptom of these two cases was abducens nerve paresis, which is caused by the tumor extending from the clivus to the cavernous sinus. The neuroradiological features were the destruction of skull base bone and angiographic tumor stain. Histopathological examination of the surgically resected specimens revealed clear cell carcinoma, and thereafter they were diagnosed as skull base metastasis from renal cell carcinoma. We emphasize the necessity of a thorough medical workup to enable speedy diagnosis of renal cell carcinoma in such cases.
authors.affiliation: Department of Neurosurgery, School of Medicine, Keio University.
authors.forename: M
authors.initials: M
authors.lastname: Sagoh
authors.forename: K
authors.initials: K
authors.lastname: Kodaki
authors.forename: K
authors.initials: K
authors.lastname: Ichikizaki
authors.forename: K
authors.initials: K
authors.lastname: Murakami
authors.forename: T
authors.initials: T
authors.lastname: Oizumi
authors.forename: T
authors.initials: T
authors.lastname: Kawase
authors.forename: S
authors.initials: S
authors.lastname: Toya
authors.forename: H
authors.initials: H
authors.lastname: Shiga
mesh_terms: D000010:Abducens Nerve; D018262:Adenocarcinoma, Clear Cell / Q000150:complications / Q000473:pathology / Q000556:secondary*; D000328:Adult; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010243:Paralysis / Q000209:etiology*; D019292:Skull Base Neoplasms / Q000150:complications / Q000556:secondary*