title: The most electron-donating sites in duplex DNA: guanine-guanine stacking rule.
abstract: The most readily oxidizable sites in one-electron oxidation of duplex DNA are shown to be the guanine (G) residues located 5' to guanine. Based on experimental results and ab initio calculations, G-G stacking rule has been proposed. This rule indicates the most electron-rich sites contained in B DNA and is very useful for understanding CT interactions between electron-accepting molecules and DNA.
authors.affiliation: Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Saito
authors.forename: M
authors.initials: M
authors.lastname: Takayama
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: H
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Komeda
authors.forename: M
authors.initials: M
authors.lastname: Iwasaki
mesh_terms: D001665:Binding Sites; D004247:DNA / Q000737:chemistry*; D004579:Electron Transport; D004583:Electrons; D006147:Guanine / Q000737:chemistry*; D008956:Models, Chemical; D008958:Models, Molecular; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D010084:Oxidation-Reduction
chemical_list: D006147:Guanine; D004247:DNA