Antiarrhythmic activity of oximethers.
More than sixty 2-substituted-cycloalkanone-oxim-/2-hydroxy-3-dialkylamino/- propylethers were investigated on aconitine induced ventricular arrhythmia model in rats. According to the structure-activity relationships cyclohexanes containing diisopropylamine in the basic group were the most effective derivatives. Based on the highest per os activity and lowest toxicity EGIS-3966 (ED50 values 1.21 mg/kg iv. and 27.3 mg/kg per os) was selected for further development.
Hegedüs
M
M
EGIS Pharmaceuticals, Budapest, Hungary.
Petöcz
L
L
Budai
Z
Z
Mezei
T
T
D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D005117:Cardiac Complexes, Premature / Q000139:chemically induced / Q000517:prevention & control; D003510:Cyclohexanes / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D008297:Male; D011412:Propanolamines / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
D000889:Anti-Arrhythmia Agents; D003510:Cyclohexanes; D011412:Propanolamines; D000157:Aconitine