New bioactive marine steroids from the Okinawan soft coral Clavularia viridis.
Eight new marine steroids were isolated from the Okinawan soft coral Clavularia viridis Quoy and Gaimard. Their structures were determined based on spectroscopic analysis, chemical conversion, and X-ray crystallographic analysis. Steroids 5 and 6 showed growth inhibition activity toward HeLa S3 cells and human diploid cells in vitro.
Watanabe
K
K
Laboratory of Bioorganic Chemistry, School of Life Science, Tokyo University of Pharmacy, Japan.
Iwashima
M
M
Iguchi
K
K
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003063:Cnidaria / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D007564:Japan; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D013256:Steroids; C103409:stoloniferone 5; C103410:stoloniferone 6