The influence of dizocilpine (MK-801) on the reserpine-enhanced electromyographic stretch reflex in rats.
The electromyographic (EMG) stretch reflex in the gastrocnemius and tibialis anterior muscles was elicited by passive bending and stretching of the rat's hind foot in the ankle joint. The EMG stretch reflex was increased by pretreatment with reserpine (10 mg/kg ip) which is a model compound commonly used to induce parkinsonian rigidity in laboratory animals. Dizocilpine (MK-801) (0.32, 0.64 and 1.28 mg/kg sc) inhibited long-latency supraspinal components of the reserpine-increased EMG stretch reflex, whereas a short-latency spinal component was not diminished. The present results suggest that MK-801 exhibits an antiparkinsonian action against reserpine-induced rigidity.
Ossowska
K
K
Department of Neuropsychopharmacology, Polish Academy of Sciences, Kraków, Poland.
Lorenc-Koci
E
E
Schulze
G
G
Wolfarth
S
S
D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology* / Q000627:therapeutic use; D004298:Dopamine / Q000502:physiology; D004576:Electromyography; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009127:Muscle Rigidity / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000235:genetics; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000502:physiology; D012026:Reflex, Stretch / Q000187:drug effects*; D012110:Reserpine / Q000494:pharmacology* / Q000633:toxicity
D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate; D012110:Reserpine; D004298:Dopamine