title: Dopamine transporter gene polymorphism and psychiatric symptoms seen in schizophrenic patients at their first episode.
abstract: To investigate the possible role of the dopamine transporter (DAT) gene in determining the phenotype in human subjects, allele frequencies for the 40-bp variable number of tandem repeats (VNTR) polymorphism at this site were compared between 117 Japanese normal controls and 118 schizophrenic patients, including six subgroups: early-onset, those with a family history, and those suffering from one of the following psychiatric symptoms at their first episode: delusion and hallucination; disorganization; bizarre behavior; and negative symptoms. No significant differences were observed between the group as a whole or any subgroup of schizophrenic patients and controls. The results indicate that VNTR polymorphism in the DAT gene is unlikely to be a major contributor to any of the psychiatric parameters examined in the present population of schizophrenic subjects.
authors.affiliation: National Institute of Mental Health, National Center of Neurology and Psychiatry, Chiba, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Inada
authors.forename: T
authors.initials: T
authors.lastname: Sugita
authors.forename: I
authors.initials: I
authors.lastname: Dobashi
authors.forename: A
authors.initials: A
authors.lastname: Inagaki
authors.forename: Y
authors.initials: Y
authors.lastname: Kitao
authors.forename: G
authors.initials: G
authors.lastname: Matsuda
authors.forename: S
authors.initials: S
authors.lastname: Kato
authors.forename: T
authors.initials: T
authors.lastname: Takano
authors.forename: G
authors.initials: G
authors.lastname: Yagi
authors.forename: M
authors.initials: M
authors.lastname: Asai
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D002352:Carrier Proteins / Q000235:genetics*; D004247:DNA / Q000097:blood; D003702:Delusions; D050483:Dopamine Plasma Membrane Transport Proteins; D005260:Female; D005787:Gene Frequency; D006212:Hallucinations; D006801:Humans; D007564:Japan; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D008875:Middle Aged; D018598:Minisatellite Repeats; D009419:Nerve Tissue Proteins; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012016:Reference Values; D012559:Schizophrenia / Q000235:genetics*; D012563:Schizophrenia, Paranoid / Q000235:genetics; D012565:Schizophrenic Psychology
chemical_list: D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493214:SLC6A3 protein, human; D004247:DNA