Selectin synthesis and inflammation.
The selectins are a family of three cell-surface-presented glycoprotein receptors. They play a key role in the initial adhesive interaction between leukocytes and endothelial cells at sites of inflammation. The presence of selectins on the cell surface is tightly regulated and inappropriate appearance is associated with a number of inflammatory disease conditions.
Whelan
J
J
Glaxo Institute for Molecular Biology, Geneva, Switzerland.
D000595:Amino Acid Sequence; D015815:Cell Adhesion Molecules / Q000737:chemistry / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism / Q000494:pharmacology; D019040:E-Selectin / Q000096:biosynthesis / Q000737:chemistry* / Q000378:metabolism; D004727:Endothelium / Q000378:metabolism; D015870:Gene Expression / Q000235:genetics; D006023:Glycoproteins / Q000737:chemistry / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism*; D019041:L-Selectin / Q000378:metabolism; D007962:Leukocytes / Q000737:chemistry / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000378:metabolism; D019007:P-Selectin / Q000378:metabolism; D011401:Promoter Regions, Genetic / Q000235:genetics; D000080506:Sialyl Lewis X Antigen; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics; D014158:Transcription, Genetic / Q000235:genetics
D015815:Cell Adhesion Molecules; D016207:Cytokines; D019040:E-Selectin; D006023:Glycoproteins; D008565:Membrane Proteins; D009844:Oligosaccharides; D019007:P-Selectin; D000080506:Sialyl Lewis X Antigen; D014157:Transcription Factors; D019041:L-Selectin