Valproate in status epilepticus.
In patients with intractable status epilepticus who have not responded to therapy with benzodiazepines, phenytoin, and barbiturates, valproate may be a reasonable option. Extemporaneously prepared valproate rectal suppositories or retention enemas have been given in dosages of 200-1200 mg q6h in addition to phenytoin, phenobarbital, or both in adults. The pediatric dose used was 15-20 mg/kg, in addition to phenytoin and/or phenobarbital.
Holle
L M
LM
Division of Pharmacy, MD Anderson Cancer Center, University of Texas, Houston 77030, USA.
Gidal
B E
BE
Collins
D M
DM
D000818:Animals; D000927:Anticonvulsants / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001682:Biological Availability; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D006801:Humans; D013226:Status Epilepticus / Q000188:drug therapy* / Q000378:metabolism; D014635:Valproic Acid / Q000493:pharmacokinetics / Q000627:therapeutic use*
D000927:Anticonvulsants; D014635:Valproic Acid