Mapping drug-induced changes in cerebral R2* by Multiple Gradient Recalled Echo functional MRI.
A multiple Gradient Recalled Echo MRI sequence was used to map spatial and temporal changes in the rate of MR signal decay (R2*) in response to L-3,4-dihydroxyphenylalanine (levodopa) in the striatal dopaminergic system of a rhesus monkey unilaterally lesioned with 4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP). R2* decreased significantly in the right (dopamine depleted) putamen and caudate following levodopa. More focal areas of smaller R2* decline were also observed in these structures in the left hemisphere. The observed spatial and temporal patterns of R2* change support the view that the method is monitoring changes in neural activity.
Chen
Q
Q
Magnetic Resonance Imaging & Spectroscopy Center, University of Kentucky School of Medicine, Lexington, USA.
Andersen
A H
AH
Zhang
Z
Z
Ovadia
A
A
Gash
D M
DM
Avison
M J
MJ
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods*; D002230:Carbidopa / Q000494:pharmacology; D005260:Female; D007980:Levodopa / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008253:Macaca mulatta; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology
D007980:Levodopa; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D002230:Carbidopa