LHRH and somatostatin effects on the cell proliferation of the gastric epithelium of suckling and weaning rats.
The aim of this study was to investigate the effects of LHRH and somatostatin on the cell proliferation of the gastric epithelium of suckling and weaning rats after fasting treatment. Previous studies on the cell proliferation of the gastric epithelium have shown that fasting stimulates this process in suckling, but not in weaning and adult rats. As milk is the most important source of nutrients and hormones during the suckling phase, and luteinizing hormone-releasing hormone (LHRH) and somatostatin are found in milk, their possible inhibitory roles on the gastric epithelium were investigated. Metaphasic index was achieved by vincristine blockade in 18- and 22-day-old treated and non-treated rats. The results showed that at 18 days, both hormones inhibited the enhanced proliferation activity due to fasting treatment, while at 22 days, no effect was detected. Therefore, LHRH and somatostatin were considered to have inhibitory roles on the cell proliferation of the gastric epithelium in suckling rats only.
Gama
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P
Departmento de Histologia e Embriologia, Universidade de São Paulo, Brazil.
Alvares
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EP
D000818:Animals; D000833:Animals, Suckling; D001835:Body Weight / Q000187:drug effects; D002452:Cell Count / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects*; D005215:Fasting; D005753:Gastric Mucosa / Q000187:drug effects*; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000494:pharmacology*; D014886:Weaning
D007987:Gonadotropin-Releasing Hormone; D013004:Somatostatin