[The effect of intraportal chemotherapy in terms of administered dose of 5-FU].
Forty-six patients with colorectal cancer were studied for the effects of intraportal chemotherapy in terms of the administered dose of 5-FU. No liver metastases occurred in patients with a total dose of more than 4 g of 5-FU. The five-year survival rate for patients with a total dose of more than 4 g of 5-FU was 98%, which was better than that for control (72%). In patients administered 500 approximately 600 mg/body/day of 5-FU, the concentration of 5-FU in the peripheral blood was 0.022 approximately 0.027 microgram/ml. Liver dysfunction occurred in 22%, 33%, and 80% of patients administered less than 4 g, 4 approximately 4.9 g, or more than 5 g of 5-FU, respectively, but almost all of them were grade 1. These results suggest that intraportal chemotherapy administered with a total of more than 4 g of 5-FU was effective for prevention of liver metastases after resection of colorectal cancer.
Yamamura
T
T
Dept. of Surgery, St. Marianna University School of Medicine, Toyoko Hospital.
Matsuzaki
H
H
Tsukikawa
S
S
Akaishi
O
O
Ozasa
T
T
Miyake
H
H
Tanaka
K
K
Seo
K
K
Oikawa
H
H
Hanai
A
A
Kikuchi
K
K
Yamaguchi
S
S
D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D015918:Infusion Pumps, Implantable; D008099:Liver / Q000187:drug effects; D008113:Liver Neoplasms / Q000517:prevention & control*; D011379:Prognosis; D015996:Survival Rate
D005472:Fluorouracil