title: The role of histamine H1-receptors in the anticonvulsive effect of morphine against maximal electroconvulsive shock in mice.
abstract: Morphine is known to release histamine from mast cells. It is also known that histamine receptors mediate some of morphine's effects on the central nervous system. The contribution of H1- and H2-receptors to the effect of morphine on maximal electroconvulsive shock in mice was investigated in the present experiments. Morphine showed a dose-dependent anticonvulsive effect, but produced spontaneous clonic convulsions at higher doses (100 mg/kg, i.p.). The anticonvulsive effect of morphine (1 mg/kg, i.p.) was antagonized by histamine H1-receptor antagonists, dimethindene (0.1 mg/kg, i.p.) promethazine (0.4 mg/kg, i.p.) and pheniramine (30 mg/kg, i.p.), and naloxone (10 mg/kg, i.p.), but not by the H2-receptor antagonist ranitidine (10-50 micrograms, i.c.v.). These results show that morphine has an anticonvulsive effect via histamine H1-receptors against maximal electroconvulsive shock in mice.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Trakya University, Edirne, Turkey.
authors.forename: C H
authors.initials: CH
authors.lastname: Karadağ
authors.forename: A
authors.initials: A
authors.lastname: Ulugöl
authors.forename: D
authors.initials: D
authors.lastname: Dökmeci
authors.forename: I
authors.initials: I
authors.lastname: Dökmeci
mesh_terms: D000818:Animals; D004115:Dimethindene / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009020:Morphine / Q000627:therapeutic use*; D010632:Pheniramine / Q000494:pharmacology; D011398:Promethazine / Q000494:pharmacology; D011969:Receptors, Histamine H1 / Q000187:drug effects / Q000502:physiology*; D012640:Seizures / Q000188:drug therapy*
chemical_list: D006634:Histamine H1 Antagonists; D011969:Receptors, Histamine H1; D010632:Pheniramine; D004115:Dimethindene; D009020:Morphine; D011398:Promethazine