title: [An experimental study on antitumor effect of MMC-fibrin glue mixture].
abstract: In spite of postoperative chemo- and/or radiation therapy, the prognosis of advanced cancer patients undergoing palliative operation is still poor. Therefore, in order to improve the effect of chemotherapy, we made a mixture of MMC and fibrin glue (MMC-FIB) as a local chemotherapy. Using FIB with MMC, we expected to enhance the efficiency of MMC by sustained release of MMC. We examined cytotoxic effects and anti-tumor effects of the MMC-FIB using a gastric cancer cell line (MKN-28) and an esophageal cancer cell line (KE-3). Effects of the MMC-FIB were twice as strong as those of MMC on in vitro and in vivo studies. MMC-FIB is easy to make and apply to residual tumor. These results suggest that MMC-FIB is an effective treatment as a local chemotherapy for postoperative residual cancer.
authors.affiliation: First Dept. of Surgery, Kurume University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: H
authors.initials: H
authors.lastname: Yamana
authors.forename: H
authors.initials: H
authors.lastname: Fujita
authors.forename: T
authors.initials: T
authors.lastname: Ono
authors.forename: Y
authors.initials: Y
authors.lastname: Tou
authors.forename: T
authors.initials: T
authors.lastname: Fujii
authors.forename: T
authors.initials: T
authors.lastname: Uhi
authors.forename: K
authors.initials: K
authors.lastname: Shirouzu
mesh_terms: D000818:Animals; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage*; D051379:Mice; D008819:Mice, Nude; D016685:Mitomycin / Q000008:administration & dosage*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014407:Tumor Cells, Cultured
chemical_list: D015718:Fibrin Tissue Adhesive; D016685:Mitomycin