title: Preliminary evidence of an association between sensorimotor gating and distractibility in psychosis.
abstract: Impaired sensory gating and increased distractibility are key information-processing deficits in schizophrenia. This study evaluated the hypothesis that distractibility is related to reduced sensory gating. Performance on vigilance and distractibility tasks was compared to prepulse inhibition (PPI) of the acoustic startle reflex in 28 stable chronic psychotic patients. PPI significantly correlated with distractibility task score on a continuous performance test and lateralized attention on the Posner test. These results suggest that performance on tests of distractibility and lateralized attention are related to a measure of sensory gating.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA.
authors.forename: L P
authors.initials: LP
authors.lastname: Karper
authors.forename: G K
authors.initials: GK
authors.lastname: Freeman
authors.forename: C
authors.initials: C
authors.lastname: Grillon
authors.forename: C A
authors.initials: CA
authors.lastname: Morgan
authors.forename: D S
authors.initials: DS
authors.lastname: Charney
authors.forename: J H
authors.initials: JH
authors.lastname: Krystal
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001143:Arousal; D001288:Attention / Q000502:physiology*; D005260:Female; D006185:Habituation, Psychophysiologic / Q000502:physiology; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance / Q000502:physiology; D011618:Psychotic Disorders / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology*; D013216:Reflex, Startle / Q000502:physiology*; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology*; D012565:Schizophrenic Psychology
chemical_list: D014150:Antipsychotic Agents