Receptors for calcitonin, calcitonin gene related peptide, amylin, and adrenomedullin.
Calcitonin, calcitonin gene related peptide, amylin, and adrenomedullin are structurally related polypeptides characterized by a six or seven amino acid ring structure linked by a disulfide bridge and an amidated C-terminus. They exhibit overlapping biological actions as a result of cross-reactivity between the different receptors. In this article, the respective receptors and G-protein-coupled postreceptor events are reviewed in relation to some of the biological actions of the peptides.
Muff
R
R
Department of Orthopedic Surgery, University of Zurich, Switzerland.
Born
W
W
Fischer
J A
JA
D000818:Animals; D006801:Humans; D008565:Membrane Proteins / Q000032:analysis*; D058265:Receptors, Adrenomedullin; D018003:Receptors, Calcitonin / Q000032:analysis*; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000032:analysis*; D058287:Receptors, Islet Amyloid Polypeptide; D018000:Receptors, Peptide / Q000032:analysis*
D008565:Membrane Proteins; D058265:Receptors, Adrenomedullin; D018003:Receptors, Calcitonin; D018015:Receptors, Calcitonin Gene-Related Peptide; D058287:Receptors, Islet Amyloid Polypeptide; D018000:Receptors, Peptide