title: Identification of novel trans isomers of 20:5n-3 in liver lipids of rats fed a heated oil.
abstract: Trans polyunsaturated n-3 fatty acids are formed as a result of the heat treatment of vegetable oils. It was demonstrated previously that the 18:3 delta 9cis, 12 cis, 15 trans containing a cis delta 9 ethylenic bond was converted to a geometrical isomer of 20:5n-3, the 20:5 delta 5 cis, 8 cis, 11 cis, 14 cis, 17 trans. In the present study, we have identified two new isomers of eicosapentaenoic acid, the delta 11 monotrans and the delta 11, 17 ditrans isomers in liver of rats fed a heated oil. These are formed as a result of the conversion of two of the main isomers of linolenic acid which are present in refined and frying oils, the 18:3 delta 9 trans, 12 cis, 15 cis and the 18:3 delta 9 trans, 12 cis, 15 trans.
authors.affiliation: INRA, Unité de Nutrition Lipidique, Dijon, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Chardigny
authors.forename: J L
authors.initials: JL
authors.lastname: Sébédio
authors.forename: A
authors.initials: A
authors.lastname: Grandgirard
authors.forename: L
authors.initials: L
authors.lastname: Martine
authors.forename: O
authors.initials: O
authors.lastname: Berdeaux
authors.forename: J M
authors.initials: JM
authors.lastname: Vatèle
mesh_terms: D000818:Animals; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000378:metabolism; D015118:Eicosapentaenoic Acid / Q000737:chemistry / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000737:chemistry / Q000378:metabolism*; D006358:Hot Temperature; D008043:Linseed Oil / Q000008:administration & dosage* / Q000378:metabolism*; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D017550:Spectroscopy, Fourier Transform Infrared; D013237:Stereoisomerism; D017962:alpha-Linolenic Acid / Q000378:metabolism
chemical_list: D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3; D017962:alpha-Linolenic Acid; D008043:Linseed Oil; D015118:Eicosapentaenoic Acid