[Difference of lung deposition rate of disodium cromoglycate (DSCG) among three kinds of electric nebulizer].
We examined the lung deposition rate of DSCG with three kinds of electric nebulizer (NE-U03, Pari-Master, Nisshou) on 5 pediatrician skilled with inhalation therapy (31-54 years of age). Excretion of DSCG for 4 hours after inhalation in urine were highest in NE-U03 group, second in Pari-Master group and least in Nisshou group. And then we studied bronchodilating effect of sulbutamol on 18 children (7-17 years of age) with acute exacerbation of bronchial asthma with NE-U03 and Pari-Master. Asthmatic symptom score, SaO2 and pulmonary function were examined before and after inhalation. The delta %FVC, delta %FEV1.0, delta %PEF, delta %V50 and delta %V25 using NE-U03 were 10.3%, 19.1%, 25.5%, 32.5%, and 29.3% in NE-U03 group and 10.6%, 15.9%, 24.1%, 25.4% and 21.3% in Pari-Master group. The data of pulmonary obstraction in NE-03 group were better than that in Pari-Master group. From our data it is obvious that 3 kinds of electric nebulizers have different efficacy in regard to the lung deposition dose of inhaled drugs. When we compare the efficacy of drugs. When we compare the efficacy of drugs for nebulizer inhalation therapy, we should use the drug dose attained to lung and not nominal drug dose in principle.
Murayama
N
N
Osaka Prefectural Habikino Hospital.
Kameda
M
M
Takamatsu
I
I
Inoue
T
T
Doi
S
S
Toyoshima
K
K
D000293:Adolescent; D000328:Adult; D000420:Albuterol / Q000008:administration & dosage; D001249:Asthma / Q000188:drug therapy; D002648:Child; D004205:Cromolyn Sodium / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008875:Middle Aged; D009330:Nebulizers and Vaporizers
D004205:Cromolyn Sodium; D000420:Albuterol