Influence of magnesium salts on the membrane potential of human endothelial placental vessel cells.
Magnesium salts have been shown to depolarize the membrane of the smooth muscle cells of human placental arteries and veins with and without endothelial cells. In the present study, the influence of MgCl2 and MgSO4 was investigated on the membrane potential, Um, of the endothelial cells of the same vessels. Um was classically recorded with microelectrodes. The endothelial cell membrane of arteries was depolarized by MgCl2 (depolarization threshold, d th: 4 mM) and by MgSO4 (d th: 8 mM). A depolarization was also observed with the endothelial cell membrane of veins. The depolarization threshold with MgCl2 and 4MgSO4 was respectively 6 mM and 8 mM. The different thresholds indicate that the influence of MgCl2 on the endothelial cell membrane potential is higher and more direct than that of MgSO4, and confirm previous hypothesis on the effects of magnesium salts on the vascular smooth membrane cells.
Ibrahim
B
B
Laboratoire de Physiopathologie du Developpement, Université P.M. Curie, Paris, France.
Leveteau
J
J
Guiet-Bara
A
A
Bara
M
M
D004558:Electric Stimulation; D004594:Electrophysiology; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology*; D015636:Magnesium Chloride / Q000494:pharmacology; D008278:Magnesium Sulfate / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D010920:Placenta / Q000098:blood supply / Q000166:cytology / Q000187:drug effects*; D011247:Pregnancy; D012039:Regional Blood Flow / Q000187:drug effects; D015149:Tocolytic Agents / Q000494:pharmacology
D015149:Tocolytic Agents; D015636:Magnesium Chloride; D008278:Magnesium Sulfate; D008274:Magnesium