title: Oral fluconazole in the treatment of pulmonary cryptococcosis in non-AIDS patients.
abstract: Four non-AIDS patients with pulmonary cryptococcus infection who could not tolerate amphotericin B treatment were given oral fluconazole at a dose of 600 mg once daily for 4-5 weeks followed by 400 mg once daily for 10-12 weeks resulting in cure. All patients did not have relapse of disease when followed-up for 8-24 months after cessation of treatment. The very good tolerance of oral fluconazole by these patients suggests that such effective monotherapy should be evaluated further in non-AIDS patients with pulmonary cryptococcosis.
authors.affiliation: Tuberculosis and Chest Unit, Grantham Hospital, Hong Kong.
authors.forename: W W
authors.initials: WW
authors.lastname: Yew
authors.forename: P C
authors.initials: PC
authors.lastname: Wong
authors.forename: C F
authors.initials: CF
authors.lastname: Wong
authors.forename: J
authors.initials: J
authors.lastname: Lee
authors.forename: C H
authors.initials: CH
authors.lastname: Chau
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D003453:Cryptococcosis / Q000188:drug therapy*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000188:drug therapy*; D008297:Male
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole