Inhibition of feeding responses by the molluscicide, metaldehyde.
Metaldehyde, applied to the lips, inhibits spontaneous biting movements and disrupts rhythmic feeding motor output. Applied directly to the CNS, it induces a region of negetive slope conductance in the steady-state I-V curve, which could contribute towards generation of convulsant activity. Isolated muscle tissue (buccal mess, gut and foot) shows increased frequency and amplitude of contractions when exposed to metaldehyde. All these actions contribute towards the disruption of feeding behaviour.
McCrohan
C R
CR
School of Biological Sciences, University of Manchester, U.K.
Mills
J D
JD
Cheng
S C
SC
Bailey
S E
SE
D000079:Acetaldehyde / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects / Q000502:physiology; D005247:Feeding Behavior / Q000187:drug effects* / Q000502:physiology; D008195:Lymnaea / Q000187:drug effects* / Q000502:physiology*; D008975:Molluscacides / Q000494:pharmacology*; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects
D008975:Molluscacides; C002935:metaldehyde; D000079:Acetaldehyde