[The effects of phenobarbital, valproic acid and carbamazepine on the serum lipids and lipoproteins in a pediatric population].
Lipids and serum lipoproteins were analyzed in 432 epileptic children younger than 14 years of age who received chronic treatment (more than 6 months) with anticonvulsive drugs: phenobarbital (n = 255), valproic acid (n = 92) and carbamazepine (n = 85). The children were grouped according to sex, age and the drug administered and compared with 490 healthy children from the same social environment. The biochemical findings significantly different (p < 0.05) from the control population were as follows: phenobarbital increased serum total cholesterol levels in females and high density lipoproteins in both sexes. Valproic acid raised serum A-II apoprotein levels in every group and serum C-HDL levels in the 6 to 13 year old male group. Treatment with carbamazepine raised serum total cholesterol levels, C-HDL, phospholipid and A-I apoprotein in all groups, low density lipoproteins in females and B apoprotein males. The total cholesterol/LDL ratio was significantly lower in the 6 to 13 year old male group with any of the drugs used when compared to the control population.
de Juan Frigola
J
J
Departamento de Pediatría, Hospital Central de Asturias, Facultad de Medicina, Universidad de Oviedo.
Crespo Hernández
M
M
Braga Hernández
S
S
D000293:Adolescent; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology*; D002220:Carbamazepine / Q000008:administration & dosage / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy; D005260:Female; D006801:Humans; D007223:Infant; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood / Q000187:drug effects*; D008297:Male; D010634:Phenobarbital / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D014635:Valproic Acid / Q000008:administration & dosage / Q000494:pharmacology*
D000927:Anticonvulsants; D008055:Lipids; D008074:Lipoproteins; D002220:Carbamazepine; D014635:Valproic Acid; D010634:Phenobarbital