New compressed tablet rapidly disintegrating in saliva in the mouth using crystalline cellulose and a disintegrant.
We formulated a new compressed tablet which is rapidly disintegrated and dissolved in the mouth without the need to drink water. The crushing strength increased with increasing compression force and maximum values (8-18 kgf) for the formulations comprising crystalline cellulose and low-substituted hydroxypropylcellulose (L-HPC) were obtained at the compression force of 300 kgf. Rapid disintegration (within 30 s) was obtained in vitro using various compounding ratios of crystalline cellulose to L-HPC. Tablets prepared with crystalline cellulose and L-HPC rapidly disintegrated in saliva (small amount of water) in the mouth of humans.
Watanabe
Y
Y
Department of Pharmaceutics, Showa College of Pharmaceutical Sciences, Tokyo, Japan.
Koizumi
K
K
Zama
Y
Y
Kiriyama
M
M
Matsumoto
Y
Y
Matsumoto
M
M
D002482:Cellulose / Q000378:metabolism*; D003460:Crystallization; D006801:Humans; D012463:Saliva / Q000378:metabolism*; D013607:Tablets
D013607:Tablets; D002482:Cellulose