Ultraweak biophoton emission imaging of transplanted bladder cancer.
Biophoton emission or spontaneous ultraweak light emission has been observed from almost all living organisms, with intensities ranging from 10(-19) to 10(-16) W/cm2. The measurement of biophoton emission offers the attractive possibility of noninvasive monitoring of the underlying physiological function of a living system. In the present study, ultraweak biophoton emission from mice with transplanted bladder cancer was detected by a two-dimensional photon-counting system. Photon counts were observed to be 1.51-4.73 times higher from the regions of untreated tumor than from normal regions. Our study suggests that this novel technique may be applicable to the diagnosis of superficial tumors.
Amano
T
T
Department of Urology, Kanazawa University, Japan.
Kobayashi
M
M
Devaraj
B
B
Usa
M
M
Inaba
H
H
D000818:Animals; D004867:Equipment Design; D005260:Female; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D017785:Photons; D013679:Technology, Radiologic / Q000295:instrumentation; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000503:physiopathology*