title: Selective bilateral lesion of the globus pallidus: ten-year follow-up of memory impairment and frontal symptomatology.
abstract: A case of loss of psychic self-activation (LPSA) and serious amnesia, followed for a period of ten years, is reported. MRI examination documents a selective bilateral lesion of the globus pallidus. This clinical picture, which evokes a cognitive and behavioral deficit of frontal lobe lesions, is attributed to a dysfunction of the frontal cortical area as a result of the breakdown of the frontostriatal circuits.
authors.affiliation: Clinica Neurologica, Università di Perugia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Piccirilli
authors.forename: P
authors.initials: P
authors.lastname: Mazzi
authors.forename: R
authors.initials: R
authors.lastname: Luccioli
authors.forename: T
authors.initials: T
authors.lastname: Sciarma
mesh_terms: D001480:Basal Ganglia Diseases / Q000473:pathology / Q000503:physiopathology* / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000503:physiopathology*; D005917:Globus Pallidus / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008569:Memory Disorders / Q000523:psychology*; D008875:Middle Aged; D009042:Motivation; D009483:Neuropsychological Tests