Involvement of GABA(B) receptor systems in action of antidepressants: baclofen but not bicuculline attenuates the effects of antidepressants on the forced swim test in rats.
Involvement of GABAergic systems in action of antidepressants was examined in the forced swim test in rats. Rats were forced to swim in a cylinder for 15 min on day 1 and for 5 min on day 2. Desipramine, mianserin and buspirone, administered after the 15-min swim session on day 1 and before the 5-min swim test on day 2, dose-dependently decreased the duration of immobility in the swim test on day 2. Baclofen attenuated the decreased duration of immobility induced by desipramine, mianserin and buspirone in the swim test, although baclofen did not affect the duration of immobility when it was injected alone. Muscimol dose-dependently decreased the duration of immobility in the swim test on day 2. Bicuculline antagonized the decreased duration of immobility induced by muscimol. However, bicuculline failed to antagonize the decreased duration of immobility induced by desipramine, mianserin and buspirone. These results suggest that GABA(B) but not GABA(A) receptor systems may be involved in action of antidepressants.
Nakagawa
Y
Y
Tsukuba Research Laboratories, Experimental Biomedical Research Inc. (Jisseiken), Ibaraki Japan.
Ishima
T
T
Ishibashi
Y
Y
Yoshii
T
T
Takashima
T
T
D000818:Animals; D000928:Antidepressive Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D001418:Baclofen / Q000494:pharmacology*; D001640:Bicuculline / Q000494:pharmacology*; D002065:Buspirone / Q000494:pharmacology; D003891:Desipramine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D018755:GABA Agonists / Q000494:pharmacology*; D018756:GABA Antagonists / Q000494:pharmacology*; D008297:Male; D008803:Mianserin / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D009118:Muscimol / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000502:physiology; D018080:Receptors, GABA-B / Q000502:physiology*; D013550:Swimming; D014836:Volition
D000928:Antidepressive Agents; D018755:GABA Agonists; D018756:GABA Antagonists; D011963:Receptors, GABA-A; D018080:Receptors, GABA-B; D008803:Mianserin; D009118:Muscimol; D001418:Baclofen; D003891:Desipramine; D002065:Buspirone; D001640:Bicuculline