A novel cDNA encoding for a LIM domain protein located at human chromosome 14q32 as a candidate for leukemic translocation.
A full-length cDNA clone encoding a zinc finger protein was isolated and sequenced. This full-length clone consists of 728 bp and has a predicted open reading frame (ORF) encoding 208 amino acids. The ORF of this polypeptide codes for the human cysteine-rich protein 2 (HCRP2) and has an amino acid sequence that is 92.8% identical to its rat homolog (RCRP2). HCRP2 was mapped to chromosome 14q32, which is a hot spot of translocation in tumor development, by fluorescent in situ hybridization (FISH).
Tsui
S K
SK
Department of Biochemistry, Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
Chan
P P
PP
Cheuk
C W
CW
Liew
C C
CC
Waye
M M
MM
Fung
K P
KP
Lee
C Y
CY
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D018076:DNA, Complementary / Q000737:chemistry; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008969:Molecular Sequence Data; D051381:Rats; D016415:Sequence Alignment; D014178:Translocation, Genetic
D018076:DNA, Complementary