title: [Stage 1 glottic laryngeal carcinoma: observations on 76 cases treated with transcutaneous radiotherapy].
abstract: In this paper the authors retrospectively review various parameters which influenced local control and survival in a series of 76 patients with Tis or T1 glottic carcinoma. All the patients (89% smokers) received radical irradiation with two oblique anterior isocentric fields (45-315 degrees), with a Cobalt unit, 5 x 5 or 6 x 6, using compensator wedges; 2 Gy were given per fraction, up to 60-66 Gy at the minimum reference isodose. The mean total dose to ICRU reference point was 68 Gy (range: 63-72 Gy). All patients achieved complete remission. Four patients only had a local recurrence and none had regional relapses. Few late side-effects were observed and among them only two grade I and one grade II, the latter requiring tracheotomy. Eight patients died of cardiovascular diseases and nine of secondary cancer. Two patients are alive with a secondary malignancy. The five-year overall survival rate is 77.5%, while NED survival is 93%; no differences in survival rates were found according to T stage, grading, field size, treatment time and total dose delivered. With reference to the current literature, the authors conclude that: a) radiotherapy permits very good local control; b) lymph nodes should not be irradiated; c) very high doses do not improve local control, but only increase late side-effects; d) the role of biologic dose inhomogeneity and overall treatment time remain to be investigated.
authors.affiliation: Divisione di Radioterapia, Presidio Ospedaliero Cremonese, Cremona.
authors.forename: A
authors.initials: A
authors.lastname: Bonetta
authors.forename: B
authors.initials: B
authors.lastname: Morrica
authors.forename: A
authors.initials: A
authors.lastname: Zingoni
authors.forename: B
authors.initials: B
authors.lastname: Caraffini
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D015996:Survival Rate