Inhibition of lung homing of B16F10 by pentoxifylline, a microfilament depolymerizing agent.
B16 melanoma has proved to be an ideal model for investigating metastasis. The parental B16F1 line grows as a localized subcutaneous tumor in C57BL/6 or DBA/2 mice. However, by means of successive intravenous transplantation, a subline B16F10 has been established. This shows preponderant lung homing when transplanted by intravenous route into C57BL/6 mice. In this paper we have shown that pentoxifylline (PTX; Hoechst), a microfilament depolymerising agent can inhibit significantly this lung homing of B16F10 cells. It also had a marginal inhibitory effect on subcutaneous tumor growth.
Gude
R P
RP
Chemotherapy and Stem Cell Biology Division, Cancer Research Institute, Bombay, India.
Ingle
A D
AD
Rao
S G
SG
D008841:Actin Cytoskeleton / Q000187:drug effects*; D000818:Animals; D005260:Female; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D008546:Melanoma, Experimental / Q000517:prevention & control / Q000556:secondary*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010431:Pentoxifylline / Q000494:pharmacology*
D010431:Pentoxifylline