Adult onset of cow's milk protein allergy with small-intestinal mucosal IgE mast cells.
We report a female patient with adult onset of cow's milk protein allergy. For 1 year, she experienced repeated gastrointestinal symptoms and had a single exercise-induced anaphylactic reaction. In addition to positive skin tests and specific IgE to milk proteins and a positive challenge test, immunohistochemistry of the small intestine showed a marked increase of IgE-positive mast cells. This finding is highly specific and could provide an additional tool for diagnosing cow's milk protein allergy and possibly also other food allergies.
Levy
F S
FS
Department of Dermatology, University of Basel, Switzerland.
Bircher
A J
AJ
Gebbers
J O
JO
D000328:Adult; D017668:Age of Onset; D001706:Biopsy; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000276:immunology* / Q000473:pathology; D008407:Mast Cells / Q000276:immunology*; D016269:Milk Hypersensitivity / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D008894:Milk Proteins / Q000276:immunology*; D012882:Skin Tests
D008894:Milk Proteins; D007073:Immunoglobulin E