title: Fatal Candida tropicalis fungaemia in a leukaemic patient receiving fluconazole prophylaxis.
abstract: A 50-year-old man with newly diagnosed acute myeloid leukaemia developed breakthrough candidaemia while receiving fluconazole as antifungal prophylaxis during remission-inducing chemotherapy. Candida tropicalis was isolated; the strain was resistant to fluconazole on in vitro sensitivity testing, a phenomenon which has not been previously reported in this setting.
authors.affiliation: Public Health Laboratory, Withington Hospital, Manchester, U.K.
authors.forename: A J
authors.initials: AJ
authors.lastname: Barnes
authors.forename: A M
authors.initials: AM
authors.lastname: Wardley
authors.forename: B A
authors.initials: BA
authors.lastname: Oppenheim
authors.forename: G R
authors.initials: GR
authors.lastname: Morgenstern
authors.forename: J H
authors.initials: JH
authors.lastname: Scarffe
authors.forename: D W
authors.initials: DW
authors.lastname: Warnock
authors.forename: E M
authors.initials: EM
authors.lastname: Johnson
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D002177:Candidiasis / Q000517:prevention & control*; D004352:Drug Resistance, Microbial; D015725:Fluconazole / Q000627:therapeutic use*; D016469:Fungemia / Q000517:prevention & control*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008297:Male; D008875:Middle Aged
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole