title: [Prostaglandin E1 (PGE1) in diagnosis and long-term therapy of erectile dysfunction].
abstract: The aim of this retrospective study was to determine the worth of prostaglandin E1 (PGE1) for the diagnosis and therapy of erectile dysfunction using the study of documents, a questionnaire and a clinical control. In testing, 58.3% of 300 patients responded completely to PGE1. Complications were pain (13%) and prolonged erections of more than 3 h (5%). Sixty-four of 300 patients began continuous therapy. Forty-three of 64 patients were evaluated retrospectively (time 5/88-9/94). Nine of 43 primary patients and 16/34 secondary patients dropped out after a medium therapy of 1 year. The main reasons for the dropouts were pain and fear of complications related to the therapy. Complications in long-term therapy were pain (35.3%), prolonged erection (0.4%), and local fibrosis (5.9%). PGE1 is not a magic drug in erectile dysfunction. The advantage of fewer prolonged erections compared to papaverine/phentolamin is restricted by the high incidence of pain. The relative lack of acceptance of autoinjection therapy in long-term follow-up demonstrates its limited value in the therapy of erectile dysfunction.
authors.affiliation: Urologische Universitätsklinik und Poliklinik, Homburg/Saar.
authors.forename: H
authors.initials: H
authors.lastname: Derouet
authors.forename: A
authors.initials: A
authors.lastname: Weirauch
authors.forename: H
authors.initials: H
authors.lastname: Bewermeier
mesh_terms: D000527:Alprostadil / Q000008:administration & dosage* / Q000009:adverse effects; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D006801:Humans; D018783:Impotence, Vasculogenic / Q000175:diagnosis / Q000188:drug therapy*; D007267:Injections; D008134:Long-Term Care; D008297:Male; D010352:Patient Dropouts; D010410:Penile Erection / Q000187:drug effects / Q000502:physiology; D012189:Retrospective Studies; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D014665:Vasodilator Agents; D000527:Alprostadil