[The effect of a lyophilized extract of the mucosa of the proximal small intestine on kidney water- and salt-excretory functions in rats].
Experiments on Wistar rats injected intragastrically deionized water (1 % of the body weight) and intra-abdominally 0.1 mg/kg of the lyophilized water extract (LWE) from the thin intestine have shown that under these conditions diuresis and excretion of K+ with the urine increase and retention of Na+ excretion decreases. After intragastric injection of isotonic NaCl solution, the LWE has exerted only the K-excretion effect. An increase in the LWE doses from 1 to 10 mg/kg has weakened all these reactions. It has been found in experiments in vitro that the LWE has exerted an activatory dose-dependent effect on Na, K-ATPase from the kidney cortex cells.
Iaremenko
M S
MS
Popovych
I L
IL
Kharlamova
O M
OM
D000818:Animals; D004231:Diuresis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000502:physiology*; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D005612:Freeze Drying; D007413:Intestinal Mucosa / Q000502:physiology*; D007583:Jejunum / Q000502:physiology*; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D009318:Natriuresis / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects / Q000378:metabolism; D014020:Tissue Extracts / Q000494:pharmacology*
D014020:Tissue Extracts; D000254:Sodium-Potassium-Exchanging ATPase