title: An open non-comparative pilot study with azithromycin in the treatment of non-gonococcal urethritis in the sexually transmitted disease clinics in Hong Kong.
abstract: The aim of this study is to find out the efficacy and safety of azithromycin in the treatment of males with uncomplicated non-gonococcal urethritis. It is an open, non-comparative study carried out in the major sexually transmitted disease clinics in Hong Kong. The subjects were 45 male outpatients with clinical symptoms and signs of acute non-gonococcal urethritis. Patients presenting with acute urethritis were examined and non-gonococcal urethritis were examined and non-gonococcal urethritis was daignosed by the positive urethral smear for white blood cells but negative for gonococcus. They were given a single 1 gram oral dose of azithromycin at the clinic. Follow-ups after one and two weeks to examine for cure and adverse events were made. The result showed that 35 out of 42 evaluable patients were cleared of urethritis. Only 2 out of 22 chlamydial antigen positive patients still remained positive at the last visit. Adverse events were not uncommon but all were only mild. We concluded that 1 gram single dose of azithromycin was effective and well tolerated in the treatment of non-gonococcal urethritis in male patients.
authors.affiliation: Department of Health, 3/F Sai Ying Pun Jockey Club Clinic, Hong Kong.
authors.forename: K K
authors.initials: KK
authors.lastname: Lo
authors.forename: P S
authors.initials: PS
authors.lastname: Ng
authors.forename: F C
authors.initials: FC
authors.lastname: Chan
authors.forename: R
authors.initials: R
authors.lastname: Su
authors.forename: K M
authors.initials: KM
authors.lastname: Ho
authors.forename: K M
authors.initials: KM
authors.lastname: Kam
mesh_terms: D000208:Acute Disease; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017963:Azithromycin / Q000008:administration & dosage / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000188:drug therapy; D005500:Follow-Up Studies; D006723:Hong Kong; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D015231:Sexually Transmitted Diseases, Bacterial / Q000188:drug therapy*; D014526:Urethritis / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin