Microbial hydroxylation of 13-ethyl-17 beta-hydroxy-18,19-dinor-17 alpha-pregn-4-en-20-yn-3-one.
The microbial transformation of the racemic mixture of 13-ethyl-17 beta-hydroxy-18,19-dinor-17 alpha-pregn-4-en-20-yn-3-one (1) was investigated. Rhizopus nigricans (AS 3.2050), R. arrhizus (AS 3.4523), Aspergillus niger (AS 3.2744), A. ochraceus (AS 3.1408), and Curvularia lunata (NRRL 4381) transformed 1 into its 10 beta-hydroxy derivative (2) as a major metabolite. Biotransformation of 1 by Aspergillus ochraceus AS 3.1408 afforded 7 beta-hydroxy derivative (3) as the only product.
Hu
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SH
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, Peoples' Republic of China.
Tian
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XF
Sun
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YH
Han
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GD
D001230:Aspergillus / Q000378:metabolism; D001711:Biotransformation; D017135:Desogestrel / Q000737:chemistry / Q000378:metabolism*; D006900:Hydroxylation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D003904:Mitosporic Fungi / Q000378:metabolism; D015394:Molecular Structure; D009652:Norpregnenes / Q000737:chemistry / Q000378:metabolism*; D012233:Rhizopus / Q000378:metabolism; D013379:Substrate Specificity
D009652:Norpregnenes; D017135:Desogestrel