title: Intraluminal micromanometry: an evaluation of the dynamic performance of micro-extrusions and sleeve sensors.
abstract: Conventional manometric techniques are unsuitable for studies in premature infants and small laboratory animals. We have therefore developed silicone rubber 5-lumen and 10-lumen micromanometric extrusions with an o.d. 2.0 mm and lumina of 0.35 mm i.d. This study evaluates the suitability of microextrusions for intraluminal perfusion manometry. Pressure offset, post-occlusion pressure rise rate and sphincter model studies were used to assess the manometric performance of the extrusions and a miniature sleeve sensor (25 mm long) at infusion rates of 0.01-0.1 mL min-1. Micro-extrusions (5-lumen/10-lumen, respectively) had offsets (per 100 cm of length) of 3.8/5.0 mmHg at 0.01 mL min-1 and 25.6/26.2 mmHg at 0.1 mL min-1 and rise rates (in 160 cm lengths) of 64/43 mmHg sec-1 at 0.01 mL min-1 and 330/224 mmHg sec-1 at 0.1 mL min-1. Infusion rates 0.025 mL min-1 produced rise rates 100 mmHg sec-1. The miniature sleeve sensor had minimal resistance to perfusion, rise rates of 3 mmHg sec-1 at 0.01 mL min-1 and 23 mmHg sec-1 at 0.1 mL min-1 and recorded pressure as accurately as a side hole. We conclude that the performance of micromanometric extrusions and sleeves is sufficient for intraluminal perfusion manometry.
authors.affiliation: Gastroenterology Unit, Women's and Children's Hospital, Adelaide, Australia.
authors.forename: T
authors.initials: T
authors.lastname: Omari
authors.forename: M
authors.initials: M
authors.lastname: Bakewell
authors.forename: R
authors.initials: R
authors.lastname: Fraser
authors.forename: C
authors.initials: C
authors.lastname: Malbert
authors.forename: G
authors.initials: G
authors.lastname: Davidson
authors.forename: J
authors.initials: J
authors.lastname: Dent
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D004068:Digestive System Physiological Phenomena; D004867:Equipment Design; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008365:Manometry / Q000295:instrumentation* / Q000379:methods; D008904:Miniaturization; D010477:Perfusion