title: Apocrine carcinoma of the lip: a case report including immunohistochemical and ultrastructural study, discussion of differential diagnosis, and review of the literature.
abstract: The light microscopic, immunohistochemical, and ultrastructural features of a case of apocrine carcinoma of the upper lip of a 54-year-old white man are described. The neoplasm had a cribriform intraductal component resembling apocrine carcinoma of the breast. The tumor had irregular borders and infiltrated skeletal muscle. The neoplastic cells had abundant eosinophilic granular cytoplasm and showed apical decapitation secretion characteristic of apocrine differentiation. The differential diagnosis is discussed with particular reference to distinction of the tumor from oncocytic carcinoma and ductal carcinoma of minor salivary gland.
authors.affiliation: Department of Laboratory Medicine, British Columbia Cancer Agency, Vancouver, Canada.
authors.forename: M M
authors.initials: MM
authors.lastname: Hayes
authors.forename: J P
authors.initials: JP
authors.lastname: Matisic
authors.forename: L
authors.initials: L
authors.lastname: Weir
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure*; D000912:Antibodies, Neoplasm / Q000032:analysis; D001050:Apocrine Glands / Q000473:pathology; D001053:Apolipoproteins; D053399:Apolipoproteins D; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002277:Carcinoma / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure; D002352:Carrier Proteins / Q000032:analysis; D003937:Diagnosis, Differential; D006023:Glycoproteins; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000032:analysis; D008048:Lip Neoplasms / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure*; D008297:Male; D026901:Membrane Transport Proteins; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000175:diagnosis
chemical_list: C024328:APOD protein, human; D000912:Antibodies, Neoplasm; D001053:Apolipoproteins; D053399:Apolipoproteins D; C091202:B72.3 antibody; D002272:Carcinoembryonic Antigen; D002352:Carrier Proteins; D006023:Glycoproteins; D026901:Membrane Transport Proteins; D007633:Keratins