title: Causes of death in osteogenesis imperfecta.
abstract: OBJECTIVE
  To determine the causes of death in patients with osteogenesis imperfecta, excluding infants with the perinatal lethal form (type II).
  
  
  METHODS
  Seventy nine patients with known osteogenesis imperfecta were identified, 37 of whom had been seen clinically in life. Causes of death were identified from death certificates, postmortem reports, medical records, hospital consultants, relatives, and the Brittle Bone Society's records.
  
  
  RESULTS
  Patients with the milder types of osteogenesis imperfecta, I and IV, often had a normal lifespan and died of unrelated illnesses such as myocardial infarction and malignancy. In some of these patients and in many patients with the more severe type III disease, it was clear that osteogenesis imperfecta contributed significantly to death, almost certainly to many of the respiratory deaths and to deaths from cardiac failure due to kyphoscoliosis. Osteogenesis imperfecta also caused six deaths, directly or indirectly, due to basilar invagination of the skull. Osteogenesis imperfecta may have contributed to deaths from intracranial bleeding. Apparently minor traumatic incidents may have disastrous consequences in patients with this disorder.
  
  
  CONCLUSIONS
  Prompt care for respiratory infections and prevention of trauma in patients with osteogenesis imperfecta is essential.
authors.affiliation: Department of Biochemical Medicine, Ninewells Hospital, Dundee.
authors.forename: S J
authors.initials: SJ
authors.lastname: McAllion
authors.forename: C R
authors.initials: CR
authors.lastname: Paterson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000209:etiology / Q000401:mortality; D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008171:Lung Diseases / Q000209:etiology / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000209:etiology / Q000401:mortality; D010013:Osteogenesis Imperfecta / Q000150:complications / Q000401:mortality*