title: Early results with antegrade collagen injection for post-radical prostatectomy stress urinary incontinence.
abstract: OBJECTIVE
  Results of retrograde transurethral collagen injection for treatment of stress urinary incontinence have been generally disappointing for men with intrinsic sphincter deficiency following radical prostatectomy. We describe a new technique of antegrade transvesical collagen injection using suprapublic percutaneous bladder access.
  
  
  METHODS
  Between October 1994 and January 1996, 20 patients underwent antegrade collagen injection for post-radical prostatectomy stress urinary incontinence. Evaluation by pad test, urodynamics and subjective scores was performed before and after injection.
  
  
  RESULTS
  At a mean followup of 8.5 months 9 of 20 patients (45%) had significant subjective improvement and 5 (25%) were totally dry.
  
  
  CONCLUSIONS
  Antegrade collagen injection is a promising and simple method of correcting post-radical prostatectomy stress urinary incontinence. Further study and longer followup are necessary to determine its precise role in the treatment of this condition.
authors.affiliation: Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
authors.forename: C G
authors.initials: CG
authors.lastname: Klutke
authors.forename: R B
authors.initials: RB
authors.lastname: Nadler
authors.forename: D
authors.initials: D
authors.lastname: Tiemann
authors.forename: G L
authors.initials: GL
authors.lastname: Andriole
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003094:Collagen / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections / Q000379:methods; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy / Q000009:adverse effects*; D013997:Time Factors; D014550:Urinary Incontinence, Stress / Q000209:etiology / Q000628:therapy*
chemical_list: D003094:Collagen