Neurotransmitter amino acids in cerebrospinal fluid of patients with Parkinson's disease.
We measured the CSF and plasma levels of glutamate, glutamine, aspartate (only in plasma), asparagine, glutamine, glycine and GABA in 31 patients with Parkinson's disease and in 45 matched controls. We used an ion-exchange chromatography method. When compared to controls, PD patients had similar CSF levels of glutamate, glutamine, asparagine, and glycine higher CSF GABA levels higher plasma levels of glutamine, asparagine, and glycine, and lower plasma levels of aspartate. The CSF levels of the amino acids measured were not correlated with the clinical features of PD. Our results that CSF GABA levels are not decreased in PD as previously suggested.
Jiménez-Jiménez
F J
FJ
Department of Neurology, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain.
Molina
J A
JA
Vargas
C
C
Gómez
P
P
Navarro
J A
JA
Benito-León
J
J
Ortí-Pareja
M
M
Gasalla
T
T
Cisneros
E
E
Arenas
J
J
D000368:Aged; D000596:Amino Acids / Q000097:blood / Q000134:cerebrospinal fluid*; D001216:Asparagine / Q000097:blood / Q000134:cerebrospinal fluid; D001224:Aspartic Acid / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D018698:Glutamic Acid / Q000097:blood / Q000134:cerebrospinal fluid; D005973:Glutamine / Q000097:blood / Q000134:cerebrospinal fluid; D005998:Glycine / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D008297:Male; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000097:blood / Q000134:cerebrospinal fluid*; D010300:Parkinson Disease / Q000097:blood / Q000134:cerebrospinal fluid*; D005680:gamma-Aminobutyric Acid / Q000097:blood / Q000134:cerebrospinal fluid
D000596:Amino Acids; D018377:Neurotransmitter Agents; D005973:Glutamine; D001224:Aspartic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D001216:Asparagine; D005998:Glycine