title: Clinical evaluation of a peritoneal dialysis kinetic modeling set.
abstract: A closed system kinetic modeling set (KMS) has been fabricated which permits collection of a small 100-mL aliquot from each exchange. The KMS was used to collect aliquots from 65 exchanges in 13 patients. The concentrations of urea nitrogen (UN), creatinine (Cr), glucose (G), and total protein (TP) were measured in each individual aliquot (Cka) and drain bag (Cba), and all aliquots for each dialysis treatment were used to calculate the concentrations expected in total batched dialysate (BaC) for the treatment and were compared to the measured concentrations (BaM) in mixed total dialysate. The ratios Cka/Cba [mean+/- two times coefficient of variation (mean +/- 2CV)] were 1.00 +/- 5%, 1.00 +/- 5%, 1.01 +/- 10%, and 1.00 +/- 6%, respectively, for UN, Cr, G, and TP (each, n = 61). The ratios BaC/BaM (mean +/- 2CV) were 1.00 +/- 2%, 1.00 +/- 5%, 1.01 +/- 3%, and 0.99 +/- 5%, respectively, for UN, Cr, G, and TP (each, n = 15). We concluded that the KMS aliquots can be reliably used for kinetic and total clearance calculations without mixing and transporting large volumes of dialysate.
authors.affiliation: Pikes Peak Dialysis, Colorado Springs, Colorado, USA.
authors.forename: L
authors.initials: L
authors.lastname: Smith
authors.forename: T
authors.initials: T
authors.lastname: Folden
authors.forename: B
authors.initials: B
authors.lastname: Youngblood
authors.forename: F
authors.initials: F
authors.lastname: Panlilio
authors.forename: F
authors.initials: F
authors.lastname: Gotch
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D001806:Blood Urea Nitrogen; D003198:Computer Simulation; D003404:Creatinine / Q000097:blood; D015314:Dialysis Solutions / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D010530:Peritoneal Dialysis / Q000295:instrumentation*; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000295:instrumentation*
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D015314:Dialysis Solutions; D003404:Creatinine