Peroxisome proliferation associated with fibrinogen storage in the liver.
We report a patient with fibrinogen storage disease in which there was proliferation of normal-sized peroxisomes in the hepatocytes. this phenomenon has previously been described in several acquired liver diseases. We believe that this is an adaptation response due to decreased microsomal isoenzyme activity as a result of the excess accumulation of fibrinogen in the endoplasmic reticulum.
De Craemer
D
D
Department of Human Anatomy, Vrije Universiteit Brussel, Belgium.
Pipeleers-Marichal
M
M
Vandenplas
Y
Y
van den Branden
C
C
D002648:Child; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000175:diagnosis / Q000473:pathology*; D008661:Metabolism, Inborn Errors / Q000175:diagnosis / Q000473:pathology*; D008830:Microbodies / Q000473:pathology*
D005340:Fibrinogen