Thiopentone requirements in adults after varying pre-induction doses of fentanyl.
The thiopentone dose needed for satisfactory induction of anaesthesia was determined in 60 adult patients using a double-blinded study design. No premedication was given. The effect of pretreatment with four different doses of fentanyl on ED50 for thiopentone was determined and compared with a control group not receiving fentanyl. The cardiovascular effects of the combinations were also studied. ED50 for thiopentone was reduced from 4.0 mg.kg-1 in the control group to 2.2 mg.kg-1 in patients receiving fentanyl 5.0 micrograms.kg-1. Only in the group of patients receiving fentanyl 5.0 micrograms.kg-1 was there no significant change in systolic arterial blood pressure. An increased heart rate was noted in patients induced with thiopentone in combination with fentanyl 0.625 micrograms.kg-1. No adverse effects of thiopentone, fentanyl or the combinations were noted.
Wang
L P
LP
Department of Anaesthesia, Hillerod Hospital, Denmark.
Hermann
C
C
Westrin
P
P
D000759:Adjuvants, Anesthesia / Q000494:pharmacology*; D000328:Adult; D000768:Anesthesia, General; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004357:Drug Synergism; D005260:Female; D005283:Fentanyl / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011674:Pulse / Q000187:drug effects; D013874:Thiopental / Q000008:administration & dosage / Q000494:pharmacology*
D000759:Adjuvants, Anesthesia; D018686:Anesthetics, Intravenous; D013874:Thiopental; D005283:Fentanyl