Modified varicella-like syndrome.
After incidental exposure to natural varicella, up to 18% of vaccinees reported a breakthrough infection known as modified varicella-like syndrome (MVLS) over up to 10 years of postvaccination follow-up, compared with natural varicella occurring in similarly aged unvaccinated children at the rate of 9% per year. Children with MVLS are frequently asymptomatic, and their disease is characterized by having fewer lesions, less fever, and lasting fewer days than natural varicella. When a case of MVLS occurs there are few secondary cases, suggesting that it is infrequently transmitted. Sequelae such as secondary bacterial infection, cerebellar ataxia, encephalitis, and pneumonia occur infrequently.
Clements
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DA
Division of General Pediatrics, Duke University Medical Center, Durham, North Carolina, USA.
D002644:Chickenpox / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology*; D019433:Chickenpox Vaccine / Q000627:therapeutic use; D002648:Child; D003365:Costs and Cost Analysis; D006562:Herpes Zoster / Q000453:epidemiology / Q000517:prevention & control; D014645:Herpesvirus 3, Human / Q000276:immunology; D006801:Humans
D019433:Chickenpox Vaccine