title: Bronchoalveolar lavage with trypsin in pulmonary alveolar proteinosis.
abstract: Two cases of pulmonary alveolar proteinosis were treated with bronchoalveolar lavage (BAL) via a fibreoptic bronchoscope. Additional clinical improvement was seen when trypsin was added to the lavage fluid. Analysis of effluents in the BAL fluid showed marked reduction of protein constituents with clinical improvement after treatment with trypsin in the lavage. BAL with trypsin was well tolerated.
authors.affiliation: Fourth Department of Medicine, Kinki University School of Medicine, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nagasaka
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Ueshima
authors.forename: Y
authors.initials: Y
authors.lastname: Tohda
authors.forename: S
authors.initials: S
authors.lastname: Nakajima
mesh_terms: D018893:Bronchoalveolar Lavage / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011649:Pulmonary Alveolar Proteinosis / Q000175:diagnosis / Q000628:therapy*; D014357:Trypsin / Q000627:therapeutic use*
chemical_list: D014357:Trypsin