title: The fractional inhibitory concentration index of antimicrobial agents for bacteria and Mycoplasma isolated from the nasal swabs of cattle with respiratory diseases.
abstract: We investigated the effect of thiamphenicol plus lincomycin (TP + LCM) and thiamphenicol plus tylosin (TP + TS) combinations using checker board method on the growth of Pasteurella (P.) multocida, P. haemolytica and Mycoplasma (M.) bovis by calculating the fractional inhibitory concentration index (FIC index). The results showed that the FIC indexes of the TP + LCM combination for P. multocida, P. haemolytica and M. bovis were 0.36 +/- 0.10, 0.72 +/- 0.09 and 0.81 +/- 0.18, respectively. The FIC indexes of the TP + TS combination for P. multocida, P. haemolytica, and M. bovis were 0.79 +/- 0.20, 0.66 +/- 0.11 and 0.32 +/- 0.14, respectively. Thus, these combinations are assumed to have a more synergistic or additive effect on bacteria growth than a single antimicrobial agent.
authors.affiliation: Veterinary Clinical Training Center, Yamagata Prefectural Federation of Agricultural Mutual Aid Associations, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Katoh
authors.forename: J
authors.initials: J
authors.lastname: Sakai
authors.forename: M
authors.initials: M
authors.lastname: Itagaki
authors.forename: E
authors.initials: E
authors.lastname: Watanabe
authors.forename: D
authors.initials: D
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Ogata
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002417:Cattle; D002418:Cattle Diseases; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D008034:Lincomycin / Q000494:pharmacology; D016978:Mannheimia haemolytica / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D009174:Mycoplasma / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D009175:Mycoplasma Infections / Q000382:microbiology / Q000662:veterinary*; D009297:Nasal Mucosa / Q000382:microbiology*; D010326:Pasteurella Infections / Q000382:microbiology / Q000662:veterinary*; D016979:Pasteurella multocida / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification; D012141:Respiratory Tract Infections / Q000382:microbiology / Q000662:veterinary*; D013839:Thiamphenicol / Q000494:pharmacology; D015645:Tylosin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D008034:Lincomycin; D013839:Thiamphenicol; D015645:Tylosin