title: A prospective cohort study of the effect of vincristine on audition.
abstract: We conducted a prospective cohort study of the possible ototoxic effect of vincristine among patients treated for lymphoproliferative malignancies. No deleterious effect of moderate doses of vincristine on pure tone audiometry for air and bone conduction and on speech audiometry could be found. Nevertheless, the isolated finding of sensorineural hearing loss in the only patient who received a high dose of vincristine raises the issue of ototoxicity as a possible dose-related and dose-limiting side effect of vincristine.
authors.affiliation: Institute of Hematology, Head and Neck Surgery, Barzilai Medical Center, Ashkelon, Israel.
authors.forename: G
authors.initials: G
authors.lastname: Lugassy
authors.forename: A
authors.initials: A
authors.lastname: Shapira
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced*; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014750:Vincristine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D014750:Vincristine