Structure of the gene encoding the human differentiation-stimulating factor/leukemia inhibitory factor receptor.
The human gene encoding the differentiation-stimulating factor (D-factor)/leukemia inhibitory factor (LIF) receptor was cloned and its structure was analyzed. The gene spans more than 70 kilobases and contains 20 exons. The D-factor/LIF receptor can be subdivided into several regions; cytokine receptor homologous domain 1, an Ig-like domain, cytokine receptor homologous domain 2, three fibronectin type III domains, a transmembrane domain and a cytoplasmic region. Each domain of the receptor is encoded by a set of exons. There is a TATA sequence upstream of the transcription initiation site. One unit of the Alu sequence is present in the 5' flanking region. An NF-IL6 site is located 31 bases downstream of the transcription initiation site.
Tomida
M
M
Department of Chemotherapy, Saitama Cancer Center Research Institute.
Gotoh
O
O
D001483:Base Sequence; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics; D005091:Exons / Q000235:genetics; D005796:Genes / Q000235:genetics*; D006131:Growth Inhibitors; D006801:Humans; D015850:Interleukin-6; D007438:Introns / Q000235:genetics; D053605:Leukemia Inhibitory Factor; D053680:Leukemia Inhibitory Factor Receptor alpha Subunit; D008222:Lymphokines; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic / Q000235:genetics; D018121:Receptors, Cytokine / Q000235:genetics*; D053606:Receptors, OSM-LIF; D015183:Restriction Mapping; D017422:Sequence Analysis, DNA
D018076:DNA, Complementary; D006131:Growth Inhibitors; D015850:Interleukin-6; C507837:LIF protein, human; C507840:LIFR protein, human; D053605:Leukemia Inhibitory Factor; D053680:Leukemia Inhibitory Factor Receptor alpha Subunit; D008222:Lymphokines; D018121:Receptors, Cytokine; D053606:Receptors, OSM-LIF