Genetic variant near cytosolic phospholipase A2 associated with schizophrenia.
Two studies were undertaken to determine a possible genetic basis for alterations in phospholipid metabolism in schizophrenia. Initial results demonstrated an association in 65 schizophrenics compared with a matched normal control population. A follow-up haplotype relative risk study of 44 triads (mother, father, affected offspring), confirmed the results seen in the association study. Results suggest that a genetic variant near the promotor region of the gene for cytosolic phospholipase A2, the rate-limiting enzyme in the synthesis of prostaglandins from arachindonic acid, is associated with schizophrenia.
Hudson
C J
CJ
Schizophrenia Program, Clarke Institute of Psychiatry, Toronto, Ontario, Canada.
Kennedy
J L
JL
Gotowiec
A
A
Lin
A
A
King
N
N
Gojtan
K
K
Macciardi
F
F
Skorecki
K
K
Meltzer
H Y
HY
Warsh
J J
JJ
Horrobin
D F
DF
D005260:Female; D006239:Haplotypes; D006801:Humans; D008297:Male; D010741:Phospholipases A / Q000235:genetics*; D054467:Phospholipases A2; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics*
D010741:Phospholipases A; D054467:Phospholipases A2