Treatment of unresectable hepatocellular carcinoma: targeted therapies using iodized oil.
Arterially administered iodized oil (Lipiodol) localizes selectively in HCCs for prolonged periods. Lipiodol-based intra-arterial chemotherapy and chemoembolization have yielded tumor response rates and survival benefits better than those offered by other therapies for unresectable Okuda Stage I and II HCC. Further trials are indicated to compare the different Lipiodol-cytotoxic-embolic regimens available. Early results of Lipiodol-targeted radiotherapy are available. This is a promising therapeutic development, and warrants comparison with chemoembolization in a large prospective randomized trial.
Bhattacharya
S
S
University Departments of Surgery, Royal Free Hospital and School of Medicine, London, England.
Dusheiko
G M
GM
D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D006801:Humans; D007261:Infusions, Intra-Arterial; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D007459:Iodized Oil / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000628:therapy*
D007457:Iodine Radioisotopes; D007459:Iodized Oil