Fluoxetine treatment alters leukocyte trafficking in the intrathecal compartment of the young primate.
To evaluate possible long-term effects of exposure to monoaminergic drugs, blood and cerebrospinal fluid (CSF) samples were collected from adolescent monkeys that had been treated with desipramine and fluoxetine in infancy. This evaluation focused on the number and type of leukocytes in CSF as a reflection of cell trafficking in the intrathecal compartment. Monkeys administered fluoxetine 2 years prior to the sample collection evinced significantly higher numbers of leukocytes in CSF than did either control or desipramine-treated subjects. The elevated cell count was accounted for primarily by increased numbers of CD4+ and CD8+ lymphocytes. The finding of higher cell numbers in CSF was replicated in a second sample from the fluoxetine-treated monkey obtained 1.5 years later. Because the cell profile in blood was unaffected by the prior drug treatments, these observations indicate a need for further study of serotonergic influences on regulation of the intrathecal compartment in the developing individual.
Coe
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CL
Department of Psychology, University of Wisconsin-Madison 53706, USA.
Hou
F Y
FY
Clarke
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D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000418:Albumins / Q000134:cerebrospinal fluid; D000818:Animals; D018791:CD4 Lymphocyte Count; D002555:Cerebrospinal Fluid / Q000166:cytology; D002556:Cerebrospinal Fluid Proteins / Q000378:metabolism; D003891:Desipramine / Q000494:pharmacology; D005473:Fluoxetine / Q000494:pharmacology*; D006854:Hydrocortisone / Q000097:blood; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D007962:Leukocytes / Q000502:physiology*; D008253:Macaca mulatta; D008426:Maternal Deprivation; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D012931:Social Environment; D013116:Spinal Cord / Q000166:cytology* / Q000187:drug effects
D018759:Adrenergic Uptake Inhibitors; D000324:Adrenocorticotropic Hormone; D000418:Albumins; D002556:Cerebrospinal Fluid Proteins; D003891:Desipramine; D005473:Fluoxetine; D006854:Hydrocortisone; D007074:Immunoglobulin G; D017367:Selective Serotonin Reuptake Inhibitors