title: Surgical evaluation and management of refractory constipation in older children.
abstract: Chronic constipation is a common childhood problem that accounts for 3% to 5% of pediatric visits and 10% to 25% of referrals to pediatric gastroenterologists. The etiology of constipation can be elusive, and extensive investigation often fails to identify a specific cause. The authors conducted a 5-year retrospective review of the patients referred for deep transanal rectal biopsy to determine the usefulness of this procedure in the evaluation and subsequent surgical management of refractory constipation. Specimens obtained by transanal rectal biopsy established a diagnosis for 30 of the 70 patients, and 17 of these 30 had subsequent procedures in the treatment of their constipation. The authors conclude that transanal rectal biopsy identifies a significant number of patients with previously unidentified neuroenteric disorders who may benefit from additional surgery in the treatment of constipation refractory to medical management.
authors.affiliation: Department of Pediatric Surgery, Massachusetts General Hospital, Boston 02114, USA.
authors.forename: B B
authors.initials: BB
authors.lastname: Simpson
authors.forename: D P
authors.initials: DP
authors.lastname: Ryan
authors.forename: J J
authors.initials: JJ
authors.lastname: Schnitzer
authors.forename: A
authors.initials: A
authors.lastname: Flores
authors.forename: D P
authors.initials: DP
authors.lastname: Doody
mesh_terms: D001706:Biopsy; D002675:Child, Preschool; D002908:Chronic Disease; D003248:Constipation / Q000209:etiology / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006627:Hirschsprung Disease / Q000150:complications; D006801:Humans; D008297:Male; D009472:Neuronal Ceroid-Lipofuscinoses / Q000150:complications; D012007:Rectum / Q000473:pathology*; D012017:Referral and Consultation; D015203:Reproducibility of Results; D012189:Retrospective Studies