title: Lung maturity tests. Relation to source, clarity, gestational age and neonatal outcome.
abstract: OBJECTIVE
  To determine whether gestational age is a significant determinant of neonatal outcome, irrespective of biochemical lung maturity. The effects of specimen source and clarity on the reliability of biochemical tests for predicting respiratory distress syndrome are also evaluated.
  
  
  METHODS
  Perinatal outcome was analyzed for 904 neonates undergoing amniotic fluid maturity studies within three days of delivery from 1991 to 1993. The relationships of gestational age and biochemical maturity to neonatal outcome were examined using multivariate analysis of covariance. Test reliability was evaluated using log-linear analysis of multiway frequency tables.
  
  
  RESULTS
  Gestational age was a better predictor of neonatal outcome than biochemical lung maturity. Gestational age significantly correlated with every measure of outcome except intraventricular hemorrhage and jaundice. Test reliability was not significantly influenced by specimen source or clarity.
  
  
  CONCLUSIONS
  Results obtained using contaminated amniotic fluid are reliable when the proper technique is used. Irrespective of biochemical maturity, neonatal outcome is significantly related to gestational age. Gestational age, and not just biochemical maturity, should be considered when timing delivery.
authors.affiliation: Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA.
authors.forename: M R
authors.initials: MR
authors.lastname: Lauria
authors.forename: M P
authors.initials: MP
authors.lastname: Dombrowski
authors.forename: V
authors.initials: V
authors.lastname: Delaney-Black
authors.forename: S F
authors.initials: SF
authors.lastname: Bottoms
mesh_terms: D000653:Amniotic Fluid / Q000737:chemistry*; D005260:Female; D005325:Fetal Organ Maturity; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D016014:Linear Models; D008168:Lung / Q000196:embryology*; D015999:Multivariate Analysis; D010713:Phosphatidylcholines / Q000032:analysis; D011247:Pregnancy; D011256:Pregnancy Outcome; D011453:Prostaglandins / Q000032:analysis; D015203:Reproducibility of Results; D012127:Respiratory Distress Syndrome, Newborn / Q000175:diagnosis; D012680:Sensitivity and Specificity; D013109:Sphingomyelins / Q000032:analysis
chemical_list: D010713:Phosphatidylcholines; D011453:Prostaglandins; D013109:Sphingomyelins