title: Effects of tamoxifen on serum lipid and apolipoprotein levels in postmenopausal patients with breast cancer.
abstract: Serum lipids and apolipoprotein levels were measured in twenty postmenopausal women with primary breast cancer, before and three months after tamoxifen therapy (10 mg twice a day). Tamoxifen caused a significant reduction in total serum cholesterol (10%; P < 0.02), and in low-density lipoprotein cholesterol (17%; P < 0.01), and a significant 47% increase in the subclass 2 of the high density lipoprotein cholesterol (P < 0.01). In addition, tamoxifen caused a 16% increase in apolipoprotein A-I, a 12% decrease in apolipoprotein B (P < 0.05), and a 37% reduction in the serum concentration of lipoprotein (a) (P < 0.01). These results show that tamoxifen brings about an important improvement in serum lipid profile.
authors.affiliation: Division of Medical Oncology, Hospital Nuestra Señora de la Candelaria, Tenerife, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Morales
authors.forename: N
authors.initials: N
authors.lastname: Santana
authors.forename: A
authors.initials: A
authors.lastname: Soria
authors.forename: A
authors.initials: A
authors.lastname: Mosquera
authors.forename: J
authors.initials: J
authors.lastname: Ordovás
authors.forename: J
authors.initials: J
authors.lastname: Nóvoa
authors.forename: P
authors.initials: P
authors.lastname: Betancor
authors.forename: P F
authors.initials: PF
authors.lastname: Valerón
authors.forename: B
authors.initials: B
authors.lastname: Díaz-Chico
authors.forename: R
authors.initials: R
authors.lastname: Chirino
mesh_terms: D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001053:Apolipoproteins / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000188:drug therapy*; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008137:Longitudinal Studies; D008875:Middle Aged; D017698:Postmenopause; D013629:Tamoxifen / Q000627:therapeutic use*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D001053:Apolipoproteins; D008055:Lipids; D008074:Lipoproteins; D013629:Tamoxifen; D002784:Cholesterol