Hepatocyte growth factor in nephronophthisis-medullary cystic disease complex.
A 13-year-old Japanese girl presented with severe anemia and renal dysfunction. The nephronophthisis-medullary cystic disease complex was diagnosed from the results of renal biopsy and a family study. Immunohistochemical detection of hepatocyte growth factor in the epithelial cells of dilated renal tubules suggested that it may have a role in the development of the tubular cystic changes which are characteristic of this disease.
Yorioka
N
N
Second Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Taniguchi
Y
Y
Yamashita
K
K
Usui
K
K
Shigemoto
K
K
Harada
S
S
Taguchi
T
T
Yamakido
M
M
D000293:Adolescent; D005260:Female; D017228:Hepatocyte Growth Factor / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D052177:Kidney Diseases, Cystic / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D007684:Kidney Tubules / Q000378:metabolism / Q000473:pathology; D010531:Peritoneal Dialysis, Continuous Ambulatory
D017228:Hepatocyte Growth Factor