Effect of leukotriene D4 on tracheal mucociliary transport velocity in quails.
We investigated the effect of leukotriene D4 (LTD4) on tracheal mucociliary transport in quails. Topical application of LTD4 (0.2-2 ng) to tracheal mucosa dose-dependently increased mucociliary transport velocity (MCTV) in 5 or 10 min after application. Forty minutes after application of 2 ng of LTD4, MCTV was decreased to about 84% of that in the control group. Both the transient increase and the subsequent decrease induced by 2 ng of LTD4 were blocked by ONO-1078 (Pranlukast: 4-oxo-8-[4-(4-phenylbutoxy)-benzoylamino]-2-(tetrazol-5-yl)- 4H- 1-benzopyran) (0.03-3 mg/kg, i.m.), a specific leukotriene antagonist. These results suggest that LTD4 possesses a biphasic effect on tracheal mucociliary transport through leukotriene receptors.
Tai
S
S
Department of Pharmacological Sciences, Kumamoto University, Japan.
Kai
H
H
Isohama
Y
Y
Takahama
K
K
Miyata
T
T
D000818:Animals; D004305:Dose-Response Relationship, Drug; D017998:Leukotriene D4 / Q000494:pharmacology*; D008297:Male; D009079:Mucociliary Clearance / Q000187:drug effects*; D011784:Quail; D013997:Time Factors; D014132:Trachea / Q000187:drug effects*
D017998:Leukotriene D4