title: Genetic variant near cytosolic phospholipase A2 associated with schizophrenia.
abstract: Two studies were undertaken to determine a possible genetic basis for alterations in phospholipid metabolism in schizophrenia. Initial results demonstrated an association in 65 schizophrenics compared with a matched normal control population. A follow-up haplotype relative risk study of 44 triads (mother, father, affected offspring), confirmed the results seen in the association study. Results suggest that a genetic variant near the promotor region of the gene for cytosolic phospholipase A2, the rate-limiting enzyme in the synthesis of prostaglandins from arachindonic acid, is associated with schizophrenia.
authors.affiliation: Schizophrenia Program, Clarke Institute of Psychiatry, Toronto, Ontario, Canada.
authors.forename: C J
authors.initials: CJ
authors.lastname: Hudson
authors.forename: J L
authors.initials: JL
authors.lastname: Kennedy
authors.forename: A
authors.initials: A
authors.lastname: Gotowiec
authors.forename: A
authors.initials: A
authors.lastname: Lin
authors.forename: N
authors.initials: N
authors.lastname: King
authors.forename: K
authors.initials: K
authors.lastname: Gojtan
authors.forename: F
authors.initials: F
authors.lastname: Macciardi
authors.forename: K
authors.initials: K
authors.lastname: Skorecki
authors.forename: H Y
authors.initials: HY
authors.lastname: Meltzer
authors.forename: J J
authors.initials: JJ
authors.lastname: Warsh
authors.forename: D F
authors.initials: DF
authors.lastname: Horrobin
mesh_terms: D005260:Female; D006239:Haplotypes; D006801:Humans; D008297:Male; D010741:Phospholipases A / Q000235:genetics*; D054467:Phospholipases A2; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D010741:Phospholipases A; D054467:Phospholipases A2