Regeneration of rat corneal epithelium is delayed by the inhibitory epidermal pentapeptide (EPP).
The effect of the inhibitory epidermal pentapeptide (EPP) on regeneration of rat corneal epithelium was studied over a 24-h period after removal of the central part of the corneal epithelium by means of n-heptanol and scraping. Both unphosphorylated and phosphorylated EPP inhibited the mitotic rate and the formation of new cells to the same extent. Thus, the mitosis inhibitor that originally was isolated from mouse epidermis, acts even on the ectodermally derived corneal epithelial cells.
Wang
X L
XL
Institute of Pathology, National Hospital (Rikshospitalet), Oslo, Norway.
Elgjo
K
K
Haaskjold
E
E
D000438:Alcohols / Q000633:toxicity; D000818:Animals; D003315:Cornea / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D004848:Epithelium / Q000187:drug effects / Q000502:physiology; D005260:Female; D006131:Growth Inhibitors / Q000494:pharmacology*; D019850:Heptanol; D008938:Mitosis / Q000187:drug effects; D009842:Oligopeptides / Q000494:pharmacology*; D009883:Ophthalmic Solutions; D010766:Phosphorylation; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000187:drug effects / Q000502:physiology*; D014945:Wound Healing
D000438:Alcohols; D006131:Growth Inhibitors; D009842:Oligopeptides; D009883:Ophthalmic Solutions; C050550:epidermal pentapeptide; D019850:Heptanol; D011761:Pyrrolidonecarboxylic Acid