Hodgkin's disease after cardiac transplant: a report of two cases.
Non-Hodgkin's lymphoma is a well recognized sequela of transplant related immunosuppression. Hodgkin's disease has only rarely been described in this context. We describe two cases of Hodgkin's disease after heart and heart/lung transplants respectively. Both patients continued to receive immunosuppressive therapy with cyclosporin and prednisolone, and received combination chemotherapy. One died of Aspergillus infection following the second course of chemotherapy. The other patient completed his chemotherapy and remains in remission. We discuss the possible aetiology and management of post-transplant Hodgkin's disease.
Hood
I M
IM
Department of Haematology, Addenbrookes NHS Trust, Cambridge, UK.
Mahendra
P
P
McNeil
K
K
Marcus
R E
RE
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications; D002699:Chlorambucil / Q000008:administration & dosage; D016572:Cyclosporine / Q000009:adverse effects; D017809:Fatal Outcome; D016027:Heart Transplantation; D016041:Heart-Lung Transplantation; D006566:Herpesviridae Infections / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000472:pathogenicity; D006646:Histiocytosis, Langerhans-Cell / Q000601:surgery; D006689:Hodgkin Disease / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008172:Lung Diseases, Fungal / Q000150:complications; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000601:surgery; D011183:Postoperative Complications / Q000188:drug therapy / Q000209:etiology; D011239:Prednisolone / Q000009:adverse effects; D011241:Prednisone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D014412:Tumor Virus Infections / Q000150:complications*; D014747:Vinblastine / Q000008:administration & dosage
D000914:Antibodies, Viral; D007166:Immunosuppressive Agents; D002699:Chlorambucil; D011344:Procarbazine; D014747:Vinblastine; D016572:Cyclosporine; D011239:Prednisolone; D011241:Prednisone