Chorea.
The Huntington's disease mutation and its protein product are widely expressed in the brain, although the link to presumed excitotoxic damage is unknown. The availability of the genetic test increased the study of preclinical changes in the disease and the identification of more rare choreic illnesses. Other types of transient or permanent basal ganglia dysfunction might cause chorea.
Shannon
K M
KM
Department of Neurological Sciences, Rush-Presbyterian-St. Luka's Medical Center, Chicago, IL 60612, USA.
D001479:Basal Ganglia / Q000503:physiopathology; D002819:Chorea / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D002894:Chromosomes, Human, Pair 4; D005820:Genetic Testing; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D009483:Neuropsychological Tests; D012307:Risk Factors; D018911:Trinucleotide Repeats / Q000235:genetics