Intra-abdominal adipose tissue, physical activity and cardiovascular risk in pre- and post-menopausal women.
OBJECTIVE
Determine whether the independent inter-relationships between intra-abdominal adipose tissue (IAF) cardiovascular disease (CVD) risk, and physical activity (PA) support the hypothesis that the beneficial effect of PA of CVD risk is mediated through the effects of activity on IAF.


METHODS
Cross-sectional.


METHODS
220 female Caucasian women 17-77 years old.


METHODS
Computed tomography IAF and subcutaneous abdominal adipose tissue (SAF), percent fat, CVD risk factors (blood lipids and blood pressure) and PA using the Baecke questionnaire.


RESULTS
Zero-order correlations indicated that IAF, SAF, percent fat, age, menopausal status (MS), and all 4 of the PA indexes were consistently related to CVD risk. After adjusting for age, MS, SAF, and percent fat, IAF was negatively related to PA (r2 = 0.04), indicating that more active women had relatively small IAF compared to other fat depots. After adjusting for IAF, MS, and age none of the PA indexes were related to any of the CVD risk factors except cholesterol/HDL ratio (partial r2 = 0.02). However, after adjusting for PA, MS and age, IAF was related to all CVD risk factors except cholesterol (partial r2 = 0.03-0.23).


CONCLUSIONS
These results support the hypothesis that PA may obtain at least part of its effect on CVD risk by reducing IAF.
Hunter
G R
GR
Department of Human Studies, University of Alabama at Birmingham 35294-1250, USA.
Kekes-Szabo
T
T
Treuth
M S
MS
Williams
M J
MJ
Goran
M
M
Pichon
C
C
D000005:Abdomen; D000273:Adipose Tissue; D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D001823:Body Composition; D002318:Cardiovascular Diseases / Q000209:etiology*; D015444:Exercise; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D010809:Physical Fitness; D017698:Postmenopause; D012044:Regression Analysis; D012307:Risk Factors
D008055:Lipids