Graft-versus-leukemia effect after allogeneic bone marrow transplantation for chronic lymphocytic leukemia.
We report the case of a patient with chronic lymphocytic leukemia (CLL) with persistent lymphocytosis and lymphadenopathy after allogeneic bone marrow transplantation (BMT). After receiving a donor lymphocyte infusion on day 87 he achieved complete remission upon development of chronic graft-versus-host disease, suggesting that a graft-versus-leukemia effect is operative in this malignancy.
Rondón
G
G
Department of Hematology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Giralt
S
S
Huh
Y
Y
Khouri
I
I
Andersson
B
B
Andreeff
M
M
Champlin
R
R
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006086:Graft vs Host Disease / Q000209:etiology*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000628:therapy*; D008297:Male; D014184:Transplantation, Homologous