Canine distemper virus infection in Serengeti spotted hyenas.
Clinical signs suggestive of canine distemper virus (CDV) infection were observed among a group of spotted hyenas (Crocuta crocuta) in the Serengeti, Tanzania. Virus antigen was detected immunohistologically in a brain sample from a diseased cub. The presence of virus RNA could be demonstrated in this brain as well as in intestine and lymph node of the animal by RT-PCR. Sequence comparison of brain-derived amplicons showed that the virus was related to recent CDV field isolates. The closest homology (>99 percent) was to a recently described CDV which caused high mortality in sympatric lions.
Haas
L
L
Institute for Virology, Veterinary School, Hannover, Germany.
Hofer
H
H
East
M
M
Wohlsein
P
P
Liess
B
B
Barrett
T
T
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002335:Carnivora; D002540:Cerebral Cortex / Q000473:pathology / Q000821:virology; D004216:Distemper / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D004217:Distemper Virus, Canine / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D004285:Dogs; D005858:Germany; D010802:Phylogeny; D016133:Polymerase Chain Reaction / Q000379:methods; D013045:Species Specificity; D013636:Tanzania
D000956:Antigens, Viral