title: Kindling induces neuropsin mRNA in the mouse brain.
abstract: Neuropsin mRNA expression was analyzed and mapped in the mouse brains after kindling epileptogenesis by using in situ hybridization histochemistry. Dynamic increases of the neuropsin mRNA were observed in the layer II of prelimbic, somatosensory, auditory, perirhinal, entorhinal, and piriform cortices in an activity-dependent manner, though no neuropsin gene was expressed in these areas in control mice. In addition to the confirmation of our previous studies showing increases of mRNA in the hippocampus and amygdaloid complex, there were also remarkable increases of the neuropsin mRNA in the limbic areas, such as the accessory olfactory nucleus, the medial and lateral septal nucleus, the nucleus of diagonal band, the substantia innominata and the zona incerta. The dynamic activity-dependent changes of the gene expression and the site-specificity of neuropsin localization are suggesting that this molecule is implicated in cortical- and limbic-specific neuronal reorganization.
authors.affiliation: Department of Structural Cell Biology, Nara Institute of Science and Technology (NAIST), Japan.
authors.forename: A
authors.initials: A
authors.lastname: Okabe
authors.forename: Y
authors.initials: Y
authors.lastname: Momota
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
authors.forename: A
authors.initials: A
authors.lastname: Hirata
authors.forename: J
authors.initials: J
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Nishino
authors.forename: S
authors.initials: S
authors.lastname: Shiosaka
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000378:metabolism; D004558:Electric Stimulation; D004827:Epilepsy / Q000209:etiology / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism; D007610:Kallikreins; D007696:Kindling, Neurologic / Q000502:physiology*; D008032:Limbic System / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D012333:RNA, Messenger / Q000096:biosynthesis*; D012697:Serine Endopeptidases / Q000235:genetics* / Q000502:physiology
chemical_list: D012333:RNA, Messenger; C094799:KLK8 protein, human; D007610:Kallikreins; D012697:Serine Endopeptidases