Comparison of high performance capillary electrophoresis and liquid chromatography for the determination of acyclovir and guanine in pharmaceuticals and urine.
High-performance capillary electrophoresis (HPCE) and high-performance liquid chromatography (HPLC) were developed and applied to the determination of acyclovir (ACV) and guanine (G) in pharmaceuticals. The comparison study showed that two methods gave comparable results in linear range, recovery and reproducibility. HPCE was used for the determination of ACV and G in urine; the recovery was better than 81.3% and the RSD was less than 4.4%.
Zhang
S S
SS
Center of Instrumental Analysis, Zhengzhou University, P.R. China.
Liu
H X
HX
Chen
Y
Y
Yuan
Z B
ZB
D000212:Acyclovir / Q000032:analysis* / Q000652:urine; D000998:Antiviral Agents / Q000032:analysis* / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D019075:Electrophoresis, Capillary; D006147:Guanine / Q000032:analysis* / Q000652:urine; D006863:Hydrogen-Ion Concentration; D009994:Osmolar Concentration; D015203:Reproducibility of Results
D000998:Antiviral Agents; D006147:Guanine; D000212:Acyclovir