title: Tyrphostins IV--highly potent inhibitors of EGF receptor kinase. Structure-activity relationship study of 4-anilidoquinazolines.
abstract: Potent 4-anilido-substituted quinazolines which potently inhibit epidermal growth factor receptor (EGFR) kinase were prepared. Structure-activity relationship studies reveal high sensitivity to substitution at the aniline ring.
authors.affiliation: Department of Organic Chemistry, Alexander Silverman Institute of Life Sciences, Hebrew University of Jerusalem, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Gazit
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: H
authors.initials: H
authors.lastname: App
authors.forename: G
authors.initials: G
authors.lastname: McMahon
authors.forename: P
authors.initials: P
authors.lastname: Hirth
authors.forename: I
authors.initials: I
authors.lastname: Chen
authors.forename: A
authors.initials: A
authors.lastname: Levitzki
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors*; D010766:Phosphorylation; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D011799:Quinazolines / Q000737:chemistry*; D019311:Staurosporine / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000814:Aniline Compounds; D011799:Quinazolines; D066246:ErbB Receptors; D011493:Protein Kinase C; D019311:Staurosporine; C023650:aniline