Strong c-Jun immunoreactivity is associated with apoptotic cell death in human tumors of the central nervous system.
Strong c-Jun immunoreactivity, but not c-Fos expression, was observed in typical apoptotic cells in medulloblastomas, central neuroblastomas, malignant astrocytomas and glioblastomas, and in lymphocyte-like cells bearing nuclear fragmented DNA in medulloblastomas. In contrast, only a few proliferating cells, as revealed with PCNA immunohistochemistry, colocalized c-Jun. These results support the concept that strong c-Jun expression is associated with certain forms of cell death in human tumors of the central nervous system.
Ferrer
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Unitat de Neuropatologia, Servei d' Anatomia Patològica, Hospital Princeps d' Espanya, Universitat de Barcelona, Spain.
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D017209:Apoptosis; D016543:Central Nervous System Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D053938:DNA Fragmentation; D006801:Humans; D007150:Immunohistochemistry; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism*; D014018:Tissue Distribution
D018809:Proliferating Cell Nuclear Antigen; D016755:Proto-Oncogene Proteins c-jun