Reflexes mediated by cardiac sympathetic afferents during myocardial ischaemia: role of adenosine.
1. Myocardial ischaemia and infarction activate vagal and sympathetic sensory endings in the ischaemic myocardium, resulting in powerful reflex effects. The vagal afferents are either mechano- or chemosensitive, whereas sympathetic afferents may be mechano-, chemosensitive or both. 2. Activation of vagal afferents results in sympathoinhibitory, cardioinhibitory, vasodepressor responses. Cardiac sympathetic afferents activated during myocardial ischaemia mediate sympathoexcitatory, vasoconstrictor cardioaccelerator responses. 3. The focus of the present review is on the activation of sympathetic afferents by myocardial ischaemia and on the resulting reflex responses that they mediate. 4. These endings are more likely to be activated as the degree of ischaemia progresses from subendocardial towards transmural. They are evenly distributed between the anterior and inferoposterior wall. Although it has been suggested that these endings are activated by bradykinin, recent evidence indicates that they are activated by adenosine released from the ischaemic myocardium. Results from our laboratory indicate that this effect is due to the activation of adenosine A1, but not adenosine A2 receptors. 5. Activation of ventricular vagal and sympathetic afferent fibres during myocardial ischaemia in humans is responsible for the autonomic changes observed and, in the case of the sympathetic afferents, for the sensation of angina pectoris.
Thames
M D
MD
Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Dibner-Dunlap
M E
ME
Minisi
A J
AJ
Kinugawa
T
T
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D002317:Cardiovascular Agents / Q000494:pharmacology*; D006329:Heart Conduction System / Q000503:physiopathology; D006801:Humans; D017202:Myocardial Ischemia / Q000503:physiopathology*; D009475:Neurons, Afferent / Q000502:physiology*; D012018:Reflex / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014630:Vagus Nerve / Q000502:physiology
D002317:Cardiovascular Agents; D000241:Adenosine