title: Whipple disease confined to the central nervous system in childhood.
abstract: In a case of pediatric Whipple disease confined to the central nervous system, white matter lesions initially appeared as areas of very low signal intensity on T1-weighted MR images and as areas of hyperintensity on proton density-weighted and T2-weighted images, and showed slight peripheral enhancement on delayed contrast-enhanced T1-weighted images. On MR studies obtained 3 and 6 months after antibiotic therapy, the lesions had decreased in size and no longer enhanced. They became progressively less hypointense on T1-weighted images and less hyperintense on T2-weighted images.
authors.affiliation: Department of Medical Imaging, Université Catholique de Louvain, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
authors.forename: T P
authors.initials: TP
authors.lastname: Duprez
authors.forename: C B
authors.initials: CB
authors.lastname: Grandin
authors.forename: C
authors.initials: C
authors.lastname: Bonnier
authors.forename: C W
authors.initials: CW
authors.lastname: Thauvoy
authors.forename: J F
authors.initials: JF
authors.lastname: Gadisseux
authors.forename: J L
authors.initials: JL
authors.lastname: Dutrieux
authors.forename: P
authors.initials: P
authors.lastname: Evrard
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001927:Brain Diseases / Q000175:diagnosis*; D002526:Cerebellar Diseases / Q000175:diagnosis; D002675:Child, Preschool; D002701:Chloramphenicol / Q000627:therapeutic use; D003287:Contrast Media; D005500:Follow-Up Studies; D005911:Gliosis / Q000473:pathology; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D008297:Male; D009336:Necrosis; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D008061:Whipple Disease / Q000175:diagnosis*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D003287:Contrast Media; D002701:Chloramphenicol; D015662:Trimethoprim, Sulfamethoxazole Drug Combination