Serum insulin-like growth factor 1 in congenital heart disease.
Serum insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), and a range of growth and nutritional variables were investigated in 62 infants with congenital heart disease and healthy controls. Infants with congenital heart disease were small, underweight, and had a reduced energy intake. Serum IGF-1 and IGFBP-3 concentrations were significantly reduced. Decreased IGF-1 and IGFBP-3 levels are observed in nutritional deficiency; similar findings in congenital heart disease suggest that undernutrition contributes to the poor growth of these infants. Serial measurements of serum IGF-1 and IGFBP-3 may be helpful in monitoring the effect of nutritional treatment in congenital heart disease.
Barton
J S
JS
Growth Research Centre, Institute of Child Health, London.
Hindmarsh
P C
PC
Preece
M A
MA
D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002149:Energy Intake; D005260:Female; D006128:Growth / Q000502:physiology; D006330:Heart Defects, Congenital / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D007223:Infant; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male
D015415:Biomarkers; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I