title: Proliferative potential and malignant transformation of ganglioglioma: immunohistochemical studies by MIB-1 and p53 staining.
abstract: We studied two cases of ganglioglioma immunohistochemically by MIB-1 and p53 staining. The positive rate of MIB-1 in the ganglionic cells was 5.5% in Case 1 and 7.8% in Case 2, and that of MIB-1 in the gliomatous cells was 1.4 and 6.6% respectively. The labeling index of p53 in the ganglionic cells was 7.3% in Case 1 and 7.7% in Case 2, and that of the gliomatous cells was 1.9 and 3.4% respectively. MIB-1 and p53 did not stain ganglionic precursor cells. These results indicate that the ganglionic cells also take part in proliferation and have potential of malignant transformation.
authors.affiliation: Department of Neurosurgery, Dokkyo University School of Medicine.
authors.forename: M
authors.initials: M
authors.lastname: Nagai
authors.forename: T
authors.initials: T
authors.lastname: Tejima
authors.forename: T
authors.initials: T
authors.lastname: Arai
authors.forename: J
authors.initials: J
authors.lastname: Narita
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: C
authors.initials: C
authors.lastname: Ochiai
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshimoto
authors.forename: M
authors.initials: M
authors.lastname: Endoh
mesh_terms: D000368:Aged; D034961:Antigens, Nuclear; D015415:Biomarkers; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D002675:Child, Preschool; D005260:Female; D018303:Ganglioglioma / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D019394:Ki-67 Antigen; D008279:Magnetic Resonance Imaging; D009687:Nuclear Proteins / Q000378:metabolism*; D013194:Staining and Labeling; D014057:Tomography, X-Ray Computed; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D034961:Antigens, Nuclear; D015415:Biomarkers; D019394:Ki-67 Antigen; D009687:Nuclear Proteins; D016159:Tumor Suppressor Protein p53