Novel antiplatelet constituents from formosan moraceous plants.
Sixteen constituents from Formosan Moraceous plants were tested for their antiplatelet activities in rabbit platelet suspension and human platelet-rich plasma. Cycloartocarpin A, cycloheterophyllin, broussochalcone A, kazinol A, broussoaurone A, and broussoflavonol F showed strong inhibition of arachidonic acid (AA)-induced platelet aggregation. Of the compounds tested, broussochalcone A exhibited the most potent inhibition of platelet aggregation induced by AA (IC50 = 6.8 microM). The antiplatelet effects of cycloheterophyllin, broussochalcone A, kazinol B, broussoaurone A, and broussoflavonol F are partially due to an inhibitory effect on cyclooxygenase.
Lin
C N
CN
School of Pharmacy, Kaohsiung Medical College, Taiwan, Republic of China.
Lu
C M
CM
Lin
H C
HC
Fang
S C
SC
Shieh
B J
BJ
Hsu
M F
MF
Wang
J P
JP
Ko
F N
FN
Teng
C M
CM
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D010946:Plants, Medicinal / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D011817:Rabbits; D013329:Structure-Activity Relationship; D013624:Taiwan
D016861:Cyclooxygenase Inhibitors; D005419:Flavonoids; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin