title: Morphine enhancement of sucrose palatability: analysis by the taste reactivity test.
abstract: The ability of morphine to modify sucrose palatability was assessed by the taste reactivity test. In Experiment 1, rats were injected with morphine (0.0, 0.5, 2.0, and 10.0 mg/kg, subcutaneously), 30 min before receiving a 10-min intraoral infusion of 2% or 20% sucrose solution. A dose of 2.0 mg/kg morphine enhanced ingestive reactions elicited by both concentrations of sucrose solution. In Experiment 2, the interval between morphine pretreatment and the taste reactivity test was manipulated. Rats given 2.0 mg/kg morphine 30 or 120 min before testing displayed enhanced ingestive reactions elicited by 20% sucrose solution during the first 5 min of a 10-min test. The results support the hypothesis that morphine enhances the hedonic assessment of sucrose solution.
authors.affiliation: Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario.
authors.forename: H J
authors.initials: HJ
authors.lastname: Rideout
authors.forename: L A
authors.initials: LA
authors.lastname: Parker
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013395:Sucrose / Q000494:pharmacology*; D013649:Taste / Q000187:drug effects*; D013997:Time Factors
chemical_list: D013395:Sucrose; D009020:Morphine