Nonlinkage of D6S260, a putative schizophrenia locus, to bipolar affective disorder.
To examine whether genes that predispose to schizophrenia also confer a predisposition to other psychiatric disorders such as bipolar affective disorder (BAD), we tested for linkage between the recently identified schizophrenia susceptibility locus D6S260 and the inheritance of BAD in 12 large Australian pedigrees. We found no evidence for linkage over a region of 12-27 cM from the D6S260 locus, depending on the model used. Our results therefore do not provide support for the continuum theory of psychosis.
Adams
L J
LJ
School of Psychiatry, University of New South Wales, Little Bay, New South Wales, Australia.
Salmon
J
J
Donald
J A
JA
Mitchell
P B
PB
Schofield
P R
PR
D001315:Australia; D001714:Bipolar Disorder / Q000235:genetics*; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D004198:Disease Susceptibility; D005799:Genes, Dominant; D005808:Genes, Recessive; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008957:Models, Genetic; D011618:Psychotic Disorders / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics*
D005819:Genetic Markers