Lactic acid and amino acid fluctuations measured using microdialysis reflect physiological derangements in head injury.
We examined the extracellular neurochemical milieu in 34 head injured patients using microdialysis while simultaneously monitoring intracranial pressure, cerebral perfusion pressure, and jugular venous oxygen saturation. Derangements of anaerobic metabolism reflected by increased lactate and lactate/pyruvate ratios, and release of amino acids were seen at the same time as physiological deterioration in the majority of instances. Clinical microdialysis may provide insights into the neurochemistry of head injury, and such information may lead to new methods of monitoring and treating head injured patients.
Goodman
J C
JC
Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Gopinath
S P
SP
Valadka
A B
AB
Narayan
R K
RK
Grossman
R G
RG
Simpson
R K
RK
Robertson
C S
CS
D000328:Adult; D000596:Amino Acids / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D001926:Brain Death / Q000378:metabolism; D006259:Craniocerebral Trauma / Q000378:metabolism* / Q000503:physiopathology*; D005110:Extracellular Space / Q000378:metabolism; D006801:Humans; D007427:Intracranial Pressure; D007601:Jugular Veins; D019344:Lactic Acid / Q000378:metabolism*; D008297:Male; D017551:Microdialysis; D010100:Oxygen / Q000097:blood
D000596:Amino Acids; D019344:Lactic Acid; D010100:Oxygen