AIDS-related Kaposi's sarcoma. A template for the translation of molecular pathogenesis into targeted therapeutic approaches.
AIDS-related Kaposi's sarcoma (KS) represents a complex interaction of host and viral factors. There are a number of fundamental questions surrounding the interplay between the disparate factors that can contribute to the pathogenesis and pathophysiology of this disease. Targets such as the enhancement of immune function, inhibition of angiogenic factors or immunostimulatory cytokines, inhibition of viral proteins such as Tat, or hormonal manipulations are now or will in the future become the focus of research to develop innovative anti-KS therapy and prevention measures. Antiviral approaches aimed at HIV or other viruses may potentially target a number of steps in KS pathogenesis. This article reviews diverse modalities--cytotoxic, antiviral, gene-directed, growth factor-targeted, and antiangiogenesis--that singly, or more likely in combination, stand to make an impact on the cure and prevention of AIDS-related KS.
Karp
J E
JE
Chemoprevention Branch, National Cancer Institute, Bethesda, Maryland, USA.
Pluda
J M
JM
Yarchoan
R
R
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D006063:Chorionic Gonadotropin / Q000502:physiology; D016207:Cytokines / Q000627:therapeutic use; D016222:Fibroblast Growth Factor 2 / Q000502:physiology; D015696:Gene Products, tat / Q000502:physiology; D015316:Genetic Therapy; D006133:Growth Substances / Q000502:physiology; D017228:Hepatocyte Growth Factor / Q000502:physiology; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000473:pathology; D012514:Sarcoma, Kaposi / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D054322:tat Gene Products, Human Immunodeficiency Virus
D006063:Chorionic Gonadotropin; D016207:Cytokines; D015696:Gene Products, tat; D006133:Growth Substances; D054322:tat Gene Products, Human Immunodeficiency Virus; D016222:Fibroblast Growth Factor 2; D017228:Hepatocyte Growth Factor; D007372:Interferons