title: Polyactive as a bone-filler in a beagle dog model.
abstract: Calcification is a crucial step in the bone-bonding mechanism of PEO/PBT hydrogel copolymers (Polyactive, a new generation of bone-fillers. A beagle dog study was conducted to determine whether the preoperative presence of a calcium phosphate layer (precalcification) on a PEO/PBT 80/20 copolymer would further increase the bone-bonding rate. Standard bone cavities were filled with either precalcified or nonprecalcified porous cylindric PEO/PBT 80/20 implants, or hydroxyapatite granules held together with PEO/PBT 70/30, or were left unfilled. A significantly higher percentage of mineralized component was present in the cavities filled with the precalcified PEO/PBT 80/20 copolymer than in the control defects. As a result of swelling by fluid-uptake, the press-fit inserted copolymer implants showed a significant reduction in pore size, thus preventing optimal bone ingrowth. Both precalcification of the copolymer and underfilling of the defect, to create space for the copolymer to increase in diameter, stimulate postoperative calcification and bone ingrowth in PEO/PBT 80/20 copolymers.
authors.affiliation: Department of Oral-Maxillofacial Surgery, Prosthodontics and Special Dental Care, Faculty of Medicine, University of Utrecht, The Netherlands.
authors.forename: G J
authors.initials: GJ
authors.lastname: Meijer
authors.forename: A
authors.initials: A
authors.lastname: van Dooren
authors.forename: M L
authors.initials: ML
authors.lastname: Gaillard
authors.forename: R
authors.initials: R
authors.lastname: Dalmeijer
authors.forename: C
authors.initials: C
authors.lastname: de Putter
authors.forename: R
authors.initials: R
authors.lastname: Koole
authors.forename: C A
authors.initials: CA
authors.lastname: van Blitterwijk
mesh_terms: D000541:Alveolectomy; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use*; D018786:Bone Substitutes / Q000737:chemistry / Q000627:therapeutic use*; D002113:Calcification, Physiologic; D002130:Calcium Phosphates / Q000737:chemistry; D004195:Disease Models, Animal; D004285:Dogs; D017886:Durapatite / Q000737:chemistry / Q000627:therapeutic use; D005260:Female; D008297:Male; D008334:Mandible / Q000601:surgery; D008854:Microscopy, Electron; D016348:Osseointegration; D011091:Polyesters / Q000737:chemistry / Q000627:therapeutic use*; D011092:Polyethylene Glycols / Q000737:chemistry / Q000627:therapeutic use*; D016062:Porosity; D019736:Prostheses and Implants; D013499:Surface Properties; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D011091:Polyesters; C072932:polyethylene oxide-polybutylene terephthalate copolymer; D011092:Polyethylene Glycols; D017886:Durapatite