A case of nephrotic syndrome developing during postoperative gamma interferon therapy for renal cell carcinoma.
A 70-year-old man developed minimal-change nephrotic syndrome and acute interstitial nephritis while undergoing gamma interferon therapy following right nephrectomy for renal cell carcinoma. It appears that gamma interferon as well as renal cell carcinoma may have played a role as etiologic factors in this nephropathy. We report this extremely rare case of renal cell carcinoma complicated by minimal-change nephrotic syndrome and acute interstitial nephritis, and present a review of the literature.
Tashiro
M
M
Kidney Center, Toranomon Hospital, Tokyo, Japan.
Yokoyama
K
K
Nakayama
M
M
Yamada
A
A
Ogura
Y
Y
Kawaguchi
Y
Y
Sakai
O
O
D000208:Acute Disease; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000150:complications* / Q000601:surgery / Q000628:therapy*; D006801:Humans; D007371:Interferon-gamma / Q000009:adverse effects* / Q000627:therapeutic use*; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000150:complications* / Q000601:surgery / Q000628:therapy*; D008297:Male; D009392:Nephrectomy; D009395:Nephritis, Interstitial / Q000139:chemically induced / Q000150:complications; D009402:Nephrosis, Lipoid / Q000139:chemically induced* / Q000150:complications; D011994:Recombinant Proteins
D011994:Recombinant Proteins; D007371:Interferon-gamma