Eosinophil priming by cytokines: from cellular signal to in vivo modulation.
Eosinophils play an important role in the effector phase of allergic inflammation. This review will focus on the conversion of the unprimed eosinophil phenotype in the peripheral blood of normal individuals to the primed phenotype found in the peripheral blood and tissues of allergic patients, a phenomenon called priming. Recent data on the signals initiated after cytokine receptor activation on eosinophils will be reviewed.
Koenderman
L
L
Dept of Pulmonary Diseases, University Hospital Utrecht, The Netherlands.
van der Bruggen
T
T
Schweizer
R C
RC
Warringa
R A
RA
Coffer
P
P
Caldenhoven
E
E
Lammers
J W
JW
Raaijmakers
J A
JA
D002118:Calcium / Q000378:metabolism; D002450:Cell Communication; D004268:DNA-Binding Proteins / Q000378:metabolism; D004804:Eosinophils / Q000276:immunology* / Q000378:metabolism / Q000502:physiology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000096:biosynthesis / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000097:blood / Q000276:immunology*; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D007377:Interleukin-3 / Q000096:biosynthesis / Q000276:immunology; D015848:Interleukin-5 / Q000096:biosynthesis / Q000276:immunology; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism; D017452:Receptors, IgG / Q000502:physiology; D050794:STAT1 Transcription Factor; D015398:Signal Transduction / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology; D015534:Trans-Activators / Q000378:metabolism
D004268:DNA-Binding Proteins; D007377:Interleukin-3; D015848:Interleukin-5; D017452:Receptors, IgG; D050794:STAT1 Transcription Factor; C494079:STAT1 protein, human; D015534:Trans-Activators; D018799:Intercellular Adhesion Molecule-1; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D011493:Protein Kinase C; D002118:Calcium