title: Human papilloma virus has no prognostic significance in cervical carcinoma.
abstract: The prognostic significance of the detection of HPV (human papilloma virus) DNA in cervical carcinoma was evaluated in 223 cases treated from January 1988 to November 1989. HPV DNA was detected by PCR (polymerase chain reaction) on fresh tumour specimens obtained before therapy was started. HPV DNA of any type was detected in 93.3% of all tumours, HPV16 was the predominant type and was detected in 69% of cases. HPV18 was more frequent in adeno- and adenosquamous carcinoma than in squamous cell carcinoma and occurred more often in poorly differentiated tumours than in more highly differentiated tumours. Patients with HPV negative tumours were on average older than patients with tumours containing HPV. Neither presence of HPV DNA nor HPV type had prognostic significance. In 63 women with early stage tumours submitted to surgery, no difference was found in the frequency of lymph node metastasis, vessel invasion or prognosis related to HPV type. We conclude that neither the presence nor the type of HPV DNA had any prognostic significance in cervical carcinoma.
authors.affiliation: Department of Gynaecologic Oncology, Norwegian Radium Hospital, Oslo, Norway.
authors.forename: G B
authors.initials: GB
authors.lastname: Kristensen
authors.forename: F
authors.initials: F
authors.lastname: Karlsen
authors.forename: A
authors.initials: A
authors.lastname: Jenkins
authors.forename: J
authors.initials: J
authors.lastname: Kaern
authors.forename: V M
authors.initials: VM
authors.lastname: Abeler
authors.forename: C G
authors.initials: CG
authors.lastname: Tropé
mesh_terms: D000230:Adenocarcinoma / Q000821:virology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018196:Carcinoma, Adenosquamous / Q000821:virology; D002294:Carcinoma, Squamous Cell / Q000821:virology; D004279:DNA, Viral / Q000302:isolation & purification*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D011379:Prognosis; D015996:Survival Rate; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000628:therapy / Q000821:virology*
chemical_list: D004279:DNA, Viral