Molecular characterization of erythrocyte glucose-6-phosphate dehydrogenase deficiency in Al-Ain District, United Arab Emirates.
In a cross-sectional study, the activity, electrophoretic mobility and genotypes of glucose-6-phosphate dehydrogenase (G6PD) were determined among healthy, UAE national school boys from Al-Ain District in the United Arab Emirates, The prevalence of G6PD deficiency in this population sample was 11%. The majority of G6PD-deficient subjects were descendants of Omani, Baluchi or Yemeni migrants. Of 18 deficient subjects, 16 had an enzyme activity of < 10% of normal while 2 had an activity of just above 10%. Electrophoresis was performed on 166 samples and showed that, apart from deficient samples, all had the normal mobility of G6PD type B. Of the 18 deficient subjects, 14 had the B type mobility of G6PD Mediterranean and 4 had the A type mobility of G6PD A-. Genotyping demonstrated that 10 had the Mediterranean mutation while 3 had the A- mutation, consistent with their electrophoretic mobility. Another 3 had the G6PD Aures mutation, recently described as polymorphic in Algeria and Spain. The mutations in the remaining 2 subjects have not yet been identified.
Bayoumi
R A
RA
Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University.
Nur-E-Kamal
M S
MS
Tadayyon
M
M
Mohamed
K K
KK
Mahboob
B H
BH
Qureshi
M M
MM
Lakhani
M S
MS
Awaad
M O
MO
Kaeda
J
J
Vulliamy
T J
TJ
Luzzatto
L
L
D000293:Adolescent; D002648:Child; D004912:Erythrocytes / Q000201:enzymology*; D005838:Genotype; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood* / Q000453:epidemiology; D006801:Humans; D008297:Male; D015995:Prevalence; D014479:United Arab Emirates / Q000453:epidemiology