Vasculitides associated with malignancy.
Vasculitides associated with malignancies are infrequent. We can group this syndrome under three broad clinical categories: vasculitide-associated malignancies or true paraneoplastic syndrome, malignancies masquerading as vasculitides, and vasculitides masquerading as malignancies. Recent new etiopathogenic hypotheses are discussed: an immunologic dysregulation with either handling, production, or elimination of circulating immune complexes; an immunogenetic abnormality with autogenes and oncogenes with up- and/or downregulation of cell proliferation through abnormal apoptosis; and direct involvement of a virus such as human T cell lymphotropic virus type I or Epstein-Barr virus. An update on several recently reported associations between vasculitides and malignancies is presented.
Fortin
P R
PR
Division of Clinical Epidemiology, Montreal General Hospital, Quebec, Canada.
D003937:Diagnosis, Differential; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000150:complications* / Q000175:diagnosis; D010257:Paraneoplastic Syndromes; D014657:Vasculitis / Q000150:complications* / Q000175:diagnosis / Q000209:etiology