Effects of ibogaine and noribogaine on phosphoinositide hydrolysis.
The effects of the antiaddictive compound, ibogaine, and its primary metabolite, noribogaine (12-hydroxyibogamine), on phosphoinositide hydrolysis were investigated. Although ibogaine did not alter phosphoinositide turnover in either striatal or hippocampal slices, noribogaine elicited a concentration-dependent increase in the generation of [3H]inositol phosphates. This stimulation was not altered by inclusion of tetrodotoxin, cadmium or omega-conotoxin indicating that the increased production of [3H]inositol phosphates was not secondary to a release of one or more neurotransmitters. The present study indicates a stimulation of phosphoinositide hydrolysis by noribogaine may be involved in the behavioral effects of ibogaine.
Rabin
R A
RA
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo 14214-3000, USA. rarabin@acsu.buffalo.edu
Winter
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JC
D000818:Animals; D005260:Female; D006213:Hallucinogens / Q000494:pharmacology*; D006868:Hydrolysis; D007050:Ibogaine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D017072:Neostriatum / Q000187:drug effects / Q000502:physiology; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000187:drug effects; D014316:Tritium
D006213:Hallucinogens; D010716:Phosphatidylinositols; D014316:Tritium; D007050:Ibogaine; C094385:noribogaine