[The Anders Jahres Prize. Intracellular signal transmission via dioxin receptors].
The intracellular dioxin receptor mediates the biological effects of dioxins and related environmental pollutants. The dioxin receptor belongs to a novel subclass of DNA binding transcription factors. In addition to the receptor, this very class comprises a neurodevelopmental factor in Drosophila [correction of Drosphila] melanogaster, and a gene on chromosome 21 that is possibly critical for Down syndrome in man. In analogy to the dioxin receptor these factors may represent "orphan" receptors with as yet unidentified classes of ligands. The mechanism of action of the dioxin receptors is similar to that of members of the steroid hormone receptor gene family. Structurally, however, the dioxin receptor is distinct from steroid hormone receptors.
Poellinger
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Institutionen for medicinsk naringslara, Novum, Karolinska Institutet, Huddinge.
D000818:Animals; D001363:Awards and Prizes; D002891:Chromosomes, Human, Pair 21; D004314:Down Syndrome / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D018336:Receptors, Aryl Hydrocarbon / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics*; D013548:Sweden; D014157:Transcription Factors
D018336:Receptors, Aryl Hydrocarbon; D014157:Transcription Factors