The mouse vas deferens: a pharmacological preparation sensitive to nociceptin.
The newly discovered neuropeptide, nociceptin (alias orphanin FQ), was tested for its potential direct effects, as well as for its ability to modify the electrically evoked contractions in several isolated organs suspended in vitro. The electrically stimulated mouse vas deferens is a sensitive preparation on which nociceptin exerts an inhibitory effect which is not affected by naloxone. The mouse vas deferens is therefore proposed as a bioassay for nociceptin and related compounds.
Calò
G
G
Institute of Pharmacology, University of Ferrara, Italy.
Rizzi
A
A
Bogoni
G
G
Neugebauer
V
V
Salvadori
S
S
Guerrini
R
R
Bianchi
C
C
Regoli
D
D
D000595:Amino Acid Sequence; D000818:Animals; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009130:Muscle, Smooth / Q000187:drug effects*; D018847:Opioid Peptides / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000819:agonists*; D014649:Vas Deferens / Q000187:drug effects*; D000097629:Nociceptin
D018847:Opioid Peptides; D011957:Receptors, Opioid; D000097629:Nociceptin