title: Major clinical trials assessing the prophylactic use of amiodarone in patients with ventricular tachyarrhythmias.
abstract: The purpose of this article is to summarize and critique recently completed and ongoing clinical trials assessing the prophylactic use of amiodarone in patients with potentially life-threatening ventricular arrhythmias. Three of the trials compare amiodarone with an implantable cardioverter defibrillator.
authors.affiliation: Department of Medicine, Medical College of Pennsylvania, Allegheny General Hospital, Pittsburgh 15212, USA.
authors.forename: R N
authors.initials: RN
authors.lastname: Fogoros
mesh_terms: D000638:Amiodarone / Q000627:therapeutic use*; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D016757:Death, Sudden, Cardiac / Q000517:prevention & control*; D017147:Defibrillators, Implantable; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy; D016032:Randomized Controlled Trials as Topic; D013223:Statistics as Topic; D017180:Tachycardia, Ventricular / Q000188:drug therapy / Q000401:mortality / Q000517:prevention & control*
chemical_list: D000889:Anti-Arrhythmia Agents; D000638:Amiodarone