Depressed thyroid function following paediatric cardiopulmonary bypass: association with interleukin-6 release?
Cellular activation with release of cytokines such as interleukin-6 (IL-6) occurs during cardiopulmonary bypass. IL-6 regulates a number of physiologic processes, and a possible role of IL-6 was recently postulated in the pathogenesis of changes in serum thyroid hormone concentrations in patients with nonthyroidal illness. The perioperative concentrations of triiodothyronine (T3) and IL-6 were determined in ten children undergoing open-heart surgery. Significant fall in T3 concentration was found postoperatively, while IL-6 increased significantly, peaking 2 hours postoperatively. The total accumulated IL-6 level 2 hours postoperatively was correlated to postoperative T3 concentration. A significant inverse correlation was found between T3 levels 24 and 48 hours postoperatively and total accumulated IL-6, and also between the percentage decrease in T3 concentrations and total accumulated IL-6. IL-6 release thus correlated inversely to T3 levels after cardiopulmonary bypass.
Saatvedt
K
K
Department of Cardiovascular Surgery, Rikshospitalet, National Hospital, Oslo, Norway.
Lindberg
H
H
D000771:Anesthesia, Intravenous; D002315:Cardiopulmonary Bypass; D002675:Child, Preschool; D017558:Elective Surgical Procedures; D005112:Extracorporeal Circulation; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery; D006801:Humans; D007223:Infant; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D011229:Preanesthetic Medication; D013961:Thyroid Gland / Q000503:physiopathology*; D013997:Time Factors; D014284:Triiodothyronine / Q000097:blood*
D015850:Interleukin-6; D014284:Triiodothyronine