Longitudinal analysis of soluble intercellular adhesion molecule 1 in retinal vasculitis patients.
Increased levels of soluble intercellular adhesion molecule 1 (sICAM-1) in serum have been demonstrated in several human disease conditions. We have previously shown, in a point-prevalence study, a positive correlation between sICAM-1 levels and disease relapse in patients with idiopathic retinal vasculitis. We now report a longitudinal study over 1 year in which sICAM-1 levels were compared with clinical disease status in order to determine this relationship further. Serum samples from 11 patients with idiopathic retinal vasculitis were tested for the presence of sICAM-1 by enzyme linked immunosorbent assay. Eight control subjects were also tested. Five out of 11 patients presented with relapse and had raised sICAM-1 levels compared with quiescent periods of their disease. Five out of 11 patients showed no relapse over 1 year and also no increase in sICAM-1 levels. One patient showed increased levels of sICAM-1, but no clinical signs of relapse. These results indicate that sICAM-1 is associated with disease activity in retinal vasculitis patients and could indicate dysfunction of the blood-retina barrier.
Palmer
H E
HE
Department of Immunology, UMDS, St Thomas' Hospital, London, UK.
Zaman
A G
AG
Ellis
B A
BA
Stanford
M R
MR
Graham
E M
EM
Wallace
G R
GR
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000097:blood / Q000494:pharmacology; D015415:Biomarkers; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis / Q000378:metabolism*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000097:blood / Q000494:pharmacology; D012008:Recurrence; D012160:Retina / Q000378:metabolism; D014657:Vasculitis / Q000378:metabolism*
D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D018799:Intercellular Adhesion Molecule-1; D011239:Prednisolone