title: Successful use of topical retinoic acid in severe dry eye due to chronic graft-versus-host disease.
abstract: Topical retinoic acid has proved to be of variable benefit in a number of dry eye disorders of disparate aetiology, in which squamous metaplasia with keratinization of ocular epithelium is present. Its exact role in patients with dry eye however remains in dispute. We describe a case of severe dry eye due to chronic graft-versus-host disease, which was refractory to conventional therapy but which responded remarkably to topical retinoic acid with reversal of conjunctival keratinization and marked resolution of symptoms.
authors.affiliation: Department of Haematology, Leicester Royal Infirmary, UK.
authors.forename: P T
authors.initials: PT
authors.lastname: Murphy
authors.forename: M
authors.initials: M
authors.lastname: Sivakumaran
authors.forename: G
authors.initials: G
authors.lastname: Fahy
authors.forename: R M
authors.initials: RM
authors.lastname: Hutchinson
mesh_terms: D000287:Administration, Topical; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002908:Chronic Disease; D015352:Dry Eye Syndromes / Q000188:drug therapy*; D006086:Graft vs Host Disease / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014212:Tretinoin / Q000008:administration & dosage*
chemical_list: D014212:Tretinoin