Crystal and molecular structure of a histo-blood group antigen involved in cell adhesion: the Lewis x trisaccharide.
This work describes the first crystal structure ever reported of a histo-blood group carbohydrate antigen: Le(x). This study provides a detailed description of the conformation of two crystallographic independent molecules in a highly hydrated environment along with their hydrogen bonding properties and packing features. Some interactions observed between adjacent trisaccharides can provide the basis for involvement of Le(x)-Le(x) interactions in cell-cell adhesion.
Pérez
S
S
Ingeniérie Moléculaire, Institut National de la Recherche Agronomique, Nantes, France.
Mouhous-Riou
N
N
Nifant'ev
N E
NE
Tsvetkov
Y E
YE
Bachet
B
B
Imberty
A
A
D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D007983:Lewis Blood Group Antigens / Q000737:chemistry*; D016256:Lewis X Antigen / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data
D007983:Lewis Blood Group Antigens; D016256:Lewis X Antigen