Lazaroids inhibit proliferation of cultured human astrocytoma cells.
Lazaroids (or 21-aminosteroids) are potent lipid peroxidation inhibitors and are more potent antioxidants than steroids which have been shown to suppress tumor proliferation. The effects of two lazaroid compounds (U-75389G and U-83836E) were tested on the proliferation of a human brain astrocytoma cell line U-373MG. Both lazaroids had dose-dependent growth-inhibitory effects on the proliferation of U-373MG. For purposes of comparison, two steroids (methylprednisolone and dexamethasone) and a highly potent antioxidant (alpha-tocopherol) were tested under similar experimental conditions and were found to have antiproliferative effects as well, although at higher dose ranges. As cell growth-inhibitors, lazaroids are more effective than alpha-tocopherol while they are advantageous over glucocorticoids for their actions are devoid of the usual glucocorticoid side-effects.
Arora
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Neuroscience Program, Loyola University Medical Center, Maywood, IL 60153, USA.
Lee
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Origitano
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TC
Wurster
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RD
D000970:Antineoplastic Agents / Q000633:toxicity*; D000975:Antioxidants / Q000633:toxicity*; D001254:Astrocytoma; D001932:Brain Neoplasms; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D002839:Chromans / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005938:Glucocorticoids / Q000633:toxicity; D006801:Humans; D007700:Kinetics; D010879:Piperazines / Q000633:toxicity*; D013256:Steroids / Q000633:toxicity*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D000975:Antioxidants; D002839:Chromans; D005938:Glucocorticoids; D010879:Piperazines; D013256:Steroids; C102865:U 75389G; C066382:U 78517F