Inhibition of steroid-induced cataract in rat eyes by administration of vitamin-E ophthalmic solution.
The efficacy of a vitamin-E (VE) ophthalmic solution was evaluated on a newly developed rat steroid-induced cataract model. Brown Norway rats irradiated with 2 Gy X-ray, right eyes only, were divided into 5 groups: the control group; 2 steroid (1 mg/kg/day)-treated groups with topic (Top) and systemic (Sys) administration, and 2 VE-treated groups, 1 with the same treatment as the Top group with the addition of 5% VE twice a day (Top + VE) and 1 with the same treatment as the Sys group with 5% VE twice a day (SYS + VE). The lens changes were documented with a Scheimpflug camera and changes in light scattering were evaluated quantitatively. The VE-treated groups (Top + VE and Sys + VE) showed a significant inhibition of the increase in the opaque area compared with each of the non-VE-treated groups. The VE ophthalmic solution was strong enough to prevent steroid-induced cataract in rats.
Kojima
M
M
Department of Ophthalmology, Kanazawa Medical University, Ishikawa, Japan.
Shui
Y B
YB
Murano
H
H
Sasaki
K
K
D000818:Animals; D001835:Body Weight; D002386:Cataract / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D005938:Glucocorticoids / Q000633:toxicity*; D007908:Lens, Crystalline / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D008027:Light; D008297:Male; D009883:Ophthalmic Solutions; D011239:Prednisolone / Q000031:analogs & derivatives* / Q000633:toxicity; D051381:Rats; D011914:Rats, Inbred BN; D012542:Scattering, Radiation; D014810:Vitamin E / Q000008:administration & dosage*; D014965:X-Rays
D005938:Glucocorticoids; D009883:Ophthalmic Solutions; D014810:Vitamin E; C009935:prednisolone acetate; D011239:Prednisolone