title: Mycotic aortic aneurysms after orthotopic heart transplantation: a three-case report and review of the literature.
abstract: Mycotic aortic aneurysm is a rare yet life-threatening complication after orthotopic heart transplantation. This article reviews three cases of mycotic aortic aneurysm in heart transplant recipients developing in the first year after heart transplantation. Excision of the aneurysm and in situ reconstruction of the ascending aorta were performed with a patch of glutaraldehyde-fixed pericardium or cryopreserved aortic allograft material as a patch or conduit replacement. These cases show that early diagnosis by computed tomographic scanning, surgical treatment, high-dose parenteral antibiotics, and close follow-up are essential for successful treatment.
authors.affiliation: Department of Cardiothoracic and Vascular Surgery, German Heart Institute Berlin, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Knosalla
authors.forename: Y
authors.initials: Y
authors.lastname: Weng
authors.forename: H
authors.initials: H
authors.lastname: Warnecke
authors.forename: M
authors.initials: M
authors.lastname: Hummel
authors.forename: A C
authors.initials: AC
authors.lastname: Yankah
authors.forename: J
authors.initials: J
authors.lastname: Hofmeister
authors.forename: R
authors.initials: R
authors.lastname: Hetzer
mesh_terms: D000328:Adult; D000368:Aged; D000785:Aneurysm, Infected / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D000900:Anti-Bacterial Agents; D017545:Aortic Aneurysm, Thoracic / Q000209:etiology* / Q000601:surgery; D002176:Candida albicans / Q000302:isolation & purification; D002177:Candidiasis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011552:Pseudomonas Infections / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D013211:Staphylococcus aureus / Q000302:isolation & purification; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents