title: Histocompatibility antigen(s) linked to Rfp-Y (Mhc-like) genes in the chicken.
abstract: Major histocompatibility complex (Mhc) genes influencing transplantation rejections were first described in mice within the H2 complex and secondly in chickens within the B complex. In chickens, Rfp-Y haplotypes have recently been identified which contain class I and class II Mhc-like genes that assort independently of the B complex. Three Rfp-Y haplotypes have been defined in a closed breeding flock of line N chickens. In this study, progeny were obtained from line N Rfp-Y heterozygous matings to establish the role of Rfp-Y in transplantation immunity. Rfp-Y incompatibility did not induce significant one-way mixed lymphocyte responses. However, Rfp-Y-incompatible skin grafts were rejected more frequently and at a faster rate than Rfp-Y-compatible grafts by two-week-old chicks. The control Mhc B-incompatible grafts were rejected faster than the Rfp-Y-incompatible grafts; the latter were rejected at speeds that resemble rejection of minor histocompatibility antigens. We conclude that Rfp-Y class I and II Mhc-like genes are linked to the expression of minor histocompatibility antigens in chickens.
authors.affiliation: U.S. Department of Agriculture, Agricultural Research Service, Avian Disease and Oncology Laboratory, 3606 East Mount Hope Road, East Lansing, MI 48823, USA.
authors.forename: G T
authors.initials: GT
authors.lastname: Pharr
authors.forename: A V
authors.initials: AV
authors.lastname: Gwynn
authors.forename: L D
authors.initials: LD
authors.lastname: Bacon
mesh_terms: D000818:Animals; D002645:Chickens / Q000235:genetics* / Q000276:immunology; D003433:Crosses, Genetic; D005260:Female; D008040:Genetic Linkage; D006084:Graft Rejection / Q000276:immunology; D006649:Histocompatibility Antigens / Q000235:genetics*; D007959:Lymphocyte Culture Test, Mixed; D008285:Major Histocompatibility Complex; D008297:Male; D016038:Skin Transplantation / Q000276:immunology; D014181:Transplantation Immunology
chemical_list: D006649:Histocompatibility Antigens