Proliferative potential and malignant transformation of ganglioglioma: immunohistochemical studies by MIB-1 and p53 staining.
We studied two cases of ganglioglioma immunohistochemically by MIB-1 and p53 staining. The positive rate of MIB-1 in the ganglionic cells was 5.5% in Case 1 and 7.8% in Case 2, and that of MIB-1 in the gliomatous cells was 1.4 and 6.6% respectively. The labeling index of p53 in the ganglionic cells was 7.3% in Case 1 and 7.7% in Case 2, and that of the gliomatous cells was 1.9 and 3.4% respectively. MIB-1 and p53 did not stain ganglionic precursor cells. These results indicate that the ganglionic cells also take part in proliferation and have potential of malignant transformation.
Nagai
M
M
Department of Neurosurgery, Dokkyo University School of Medicine.
Tejima
T
T
Arai
T
T
Narita
J
J
Watanabe
K
K
Ochiai
C
C
Yoshimoto
Y
Y
Endoh
M
M
D000368:Aged; D034961:Antigens, Nuclear; D015415:Biomarkers; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D002675:Child, Preschool; D005260:Female; D018303:Ganglioglioma / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D019394:Ki-67 Antigen; D008279:Magnetic Resonance Imaging; D009687:Nuclear Proteins / Q000378:metabolism*; D013194:Staining and Labeling; D014057:Tomography, X-Ray Computed; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D034961:Antigens, Nuclear; D015415:Biomarkers; D019394:Ki-67 Antigen; D009687:Nuclear Proteins; D016159:Tumor Suppressor Protein p53