title: Novel antiplatelet constituents from formosan moraceous plants.
abstract: Sixteen constituents from Formosan Moraceous plants were tested for their antiplatelet activities in rabbit platelet suspension and human platelet-rich plasma. Cycloartocarpin A, cycloheterophyllin, broussochalcone A, kazinol A, broussoaurone A, and broussoflavonol F showed strong inhibition of arachidonic acid (AA)-induced platelet aggregation. Of the compounds tested, broussochalcone A exhibited the most potent inhibition of platelet aggregation induced by AA (IC50 = 6.8 microM). The antiplatelet effects of cycloheterophyllin, broussochalcone A, kazinol B, broussoaurone A, and broussoflavonol F are partially due to an inhibitory effect on cyclooxygenase.
authors.affiliation: School of Pharmacy, Kaohsiung Medical College, Taiwan, Republic of China.
authors.forename: C N
authors.initials: CN
authors.lastname: Lin
authors.forename: C M
authors.initials: CM
authors.lastname: Lu
authors.forename: H C
authors.initials: HC
authors.lastname: Lin
authors.forename: S C
authors.initials: SC
authors.lastname: Fang
authors.forename: B J
authors.initials: BJ
authors.lastname: Shieh
authors.forename: M F
authors.initials: MF
authors.lastname: Hsu
authors.forename: J P
authors.initials: JP
authors.lastname: Wang
authors.forename: F N
authors.initials: FN
authors.lastname: Ko
authors.forename: C M
authors.initials: CM
authors.lastname: Teng
mesh_terms: D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D010946:Plants, Medicinal / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D011817:Rabbits; D013329:Structure-Activity Relationship; D013624:Taiwan
chemical_list: D016861:Cyclooxygenase Inhibitors; D005419:Flavonoids; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin