title: Impairment of vitamin A uptake by rat hepatocytes and fat storing cells determined by Monensin--morphological observations.
abstract: The action of the Na+/H+ antiport monensin on vitamin A uptake by rat liver has been studied in vivo. The quickfading autofluorescence of vitamin A has been used for the determination of vitamin A uptake by the liver. Pretreatment of rats intraperitoneally with monensin decreases the uptake of vitamin A by hepatocytes and its transfer for storage to fat storing cells. Pretreatment of rats intraperitoneally with vitamin A for a short time, then with monensin, shows that the hepatocytes no longer transfer vitamin A to fat storing cells for storage. These results might indicate that monensin impairs the uptake of vitamin A by the hepatocytes and might also impair the transport of vitamin A from parenchymal to perisinusoidal cells.
authors.affiliation: Institute of General Pathology, University of Genoa, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Novelli
authors.forename: G
authors.initials: G
authors.lastname: Gambella
authors.forename: A
authors.initials: A
authors.lastname: Casu
authors.forename: F
authors.initials: F
authors.lastname: Paltrinieri
authors.forename: A
authors.initials: A
authors.lastname: Persi
authors.forename: M
authors.initials: M
authors.lastname: Canepa
authors.forename: L
authors.initials: L
authors.lastname: Carta
authors.forename: G
authors.initials: G
authors.lastname: Nanni
mesh_terms: D017667:Adipocytes / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D005260:Female; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D008985:Monensin / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014801:Vitamin A / Q000037:antagonists & inhibitors* / Q000378:metabolism*
chemical_list: D014801:Vitamin A; D008985:Monensin