A high frequency of induction of chromosome aberrations in the fibroblasts of LEC strain rats by X-irradiation.
The LEC strain of rats (LEC rats), originally developed as a model for hereditary fulminant hepatitis, is highly sensitive to whole-body X-irradiation when compared to WKAH strain of rats (WKAH rats). The present results showed that frequencies of certain types of chromosome aberrations induced by in vitro X-irradiation in the fibroblasts of LEC rats were higher than those of WKAH rats. In particular, frequencies of chromatid gaps and chromosome exchanges in LEC cells were higher approximately 4- to 5-fold and 6- to 8-fold, respectively, than those of WKAH cells.
Okui
T
T
Hokkaido Institute of Public Health, Sapporo, Japan.
Endoh
D
D
Arai
S
S
Hayashi
M
M
D000818:Animals; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects*; D005347:Fibroblasts / Q000528:radiation effects; D006501:Hepatic Encephalopathy / Q000235:genetics; D051381:Rats; D011919:Rats, Inbred Strains; D014916:Whole-Body Irradiation; D014965:X-Rays