title: The role of low-density lipoprotein apheresis as postoperative care of bypass grafting for chronic arterial occlusion.
abstract: Since November 1989, low-density lipoprotein apheresis has been applied to patients with intractable hyperlipidaemia following bypass grafting for chronic arterial occlusion of the lower extremities. The treatment group comprised six patients (four men, two women) with arteriosclerosis obliterans. In five patients, the ankle pressure index deteriorated and intermittent claudication recurred due to atherosclerotic progression. Results of low-density lipoprotein apheresis were dramatic; the deteriorated ankle pressure index and intermittent claudication improved significantly after several applications of low-density lipoprotein apheresis. Significant angiographic improvement was obtained in two patients. It is concluded that low-density lipoprotein apheresis appears to be an efficient method to preserve graft patency and treat postoperative patients with deteriorated ankle pressure index.
authors.affiliation: Department of Cardiovascular Surgery, Nagasaki University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Takagi
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: H
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: H
authors.initials: H
authors.lastname: Hashiyada
authors.forename: M
authors.initials: M
authors.lastname: Narimatsu
authors.forename: R
authors.initials: R
authors.lastname: Shibata
authors.forename: H
authors.initials: H
authors.lastname: Yamauchi
authors.forename: N
authors.initials: N
authors.lastname: Miyagawa
authors.forename: T
authors.initials: T
authors.lastname: Kugimiya
mesh_terms: D000792:Angiography; D001162:Arteriosclerosis Obliterans / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery*; D001781:Blood Component Removal; D001807:Blood Vessel Prosthesis; D005260:Female; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular / Q000097:blood / Q000000981:diagnostic imaging / Q000628:therapy; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000000981:diagnostic imaging / Q000628:therapy*; D007091:Image Processing, Computer-Assisted; D007383:Intermittent Claudication / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery; D007511:Ischemia / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery; D007866:Leg / Q000098:blood supply; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D011182:Postoperative Care; D011183:Postoperative Complications / Q000097:blood / Q000000981:diagnostic imaging / Q000628:therapy*; D012307:Risk Factors; D014680:Veins / Q000637:transplantation*
chemical_list: D008077:Lipoproteins, LDL