Effect of Clostridium difficile toxin A on CD11/CD18 expression in vitro.
Clostridium difficile toxin A is chemotactic for neutrophils and induces their emigration into the colonic mucosae of rodents. We found that toxin A did not upregulate neutrophil beta 2 integrins on isolated human neutrophils. These data support the hypothesis that in C. difficile colitis, these adhesion molecules are upregulated by endogenous mediators.
Warny
M
M
Unité de Microbiologie, Cliniques Universitaires Saint-Luc Université Catholique de Louvain, Brussels, Belgium.
Chatelain
B
B
Delmée
M
M
D001427:Bacterial Toxins / Q000633:toxicity; D018845:CD11 Antigens / Q000096:biosynthesis*; D018821:CD18 Antigens / Q000096:biosynthesis*; D002478:Cells, Cultured; D004768:Enterotoxins / Q000633:toxicity*; D006801:Humans; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism*; D015854:Up-Regulation / Q000187:drug effects
D001427:Bacterial Toxins; D018845:CD11 Antigens; D018821:CD18 Antigens; D004768:Enterotoxins; C041348:tcdA protein, Clostridium difficile