title: Loss of sensitivity to motion-defined form in patients with primary open-angle glaucoma and ocular hypertension.
abstract: During the past few years many researchers have attempted to find a psychophysical test that will identify at an early stage patients at risk for developing glaucoma. We investigated the ability of a test of motion-defined (MD) form recognition to discriminate between patients with primary open-angle glaucoma (POAG) and control subjects and to identify patients with ocular hypertension (OHT) at risk for developing glaucoma. Performance on two MD tests and three tests of static, luminance-defined (LD) form recognition was compared. Speed thresholds for reading MD letters proved to be the most sensitive test of early glaucomatous damage. 80% of POAG and 38% of OHT patients were abnormal on this test. During a 3-year follow-up period, 50% of these OHT patients developed glaucoma. These psychophysical findings support the hypothesis of early motion deficits in glaucoma.
authors.affiliation: Department of Ophthalmology, University of British Columbia, Vancouver, Canada.
authors.forename: D E
authors.initials: DE
authors.lastname: Giaschi
authors.forename: G E
authors.initials: GE
authors.lastname: Trope
authors.forename: A C
authors.initials: AC
authors.lastname: Kothe
authors.forename: X H
authors.initials: XH
authors.lastname: Hong
mesh_terms: D000328:Adult; D000368:Aged; D015350:Contrast Sensitivity / Q000502:physiology*; D005260:Female; D005556:Form Perception / Q000502:physiology*; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009039:Motion Perception / Q000502:physiology*; D009798:Ocular Hypertension / Q000503:physiopathology*; D011601:Psychophysics / Q000379:methods; D012684:Sensory Thresholds / Q000502:physiology; D014786:Vision Disorders / Q000503:physiopathology