Localized lipoatrophia with persistent circulating autoantibodies and partial immunoglobulin A deficiency in a child.
A 7-year-old Caucasian girl developed lipoatrophic areas on the abdomen and left thigh. Laboratory tests showed a partial IgA deficiency, circulating autoantibodies (ANAs, double- and single-stranded anti-DNAs, rheumatoid factor). The clinical aspect resembles lipodystrophia centrifugalis abdominalis infantilis, but autoimmune abnormalities suggest connective tissue panniculitis which underlines the overlap between the different forms of localized lipoatrophias.
Trémeau-Martinage
C
C
Department of Dermatology, Venereology and Allergology, CHU Purpan, Toulouse, France.
Bayle-Lebey
P
P
Grouteau
E
E
Bazex
J
J
D001323:Autoantibodies / Q000097:blood*; D002648:Child; D005260:Female; D006801:Humans; D017098:IgA Deficiency / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008060:Lipodystrophy / Q000150:complications* / Q000276:immunology / Q000473:pathology
D001323:Autoantibodies