Evaluation of mutagenic and cytotoxic effects of sodium fluoride on mammalian cells influenced by an acid environment.
The mutagenic activity of sodium fluoride at reduced pH was studied in the V79/HGPRT system. Statistical analysis of the results of mutagenicity testing suggests that, despite its high toxicity, sodium fluoride has no mutagenic effects at reduced pH on hamster V79 cells. Short-term treatment of cells with sodium fluoride at reduced pH inhibits growth activity of cells as well as synthesis of pulse-labeled nascent DNA and cumulative RNA synthesis and proteosynthesis. From the results of this study we suggest that an acid environment which supports formation of hydrogen fluoride increases toxic but not mutagenic potencies of sodium fluoride.
Slamenová
D
D
Cancer Research Institute of Slovak Academy of Sciences, Bratislava, Slovak Republic.
Ruppová
K
K
Gábelová
A
A
Wsólová
L
L
D000143:Acids / Q000633:toxicity*; D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D012969:Sodium Fluoride / Q000633:toxicity*
D000143:Acids; D009153:Mutagens; D012969:Sodium Fluoride; D004247:DNA; D007041:Hypoxanthine Phosphoribosyltransferase