Assignment of Alzheimer's presenilin-1 (PS-1) gene to 14q24.3 by fluorescence in situ hybridization.
Presenilin-1 (PS-1) was suggested to be localized on 14q24.3 based on linkage analysis and cDNA cloning. The final identification of PS-1 as the causal gene for Alzheimer's disease (AD) was concluded based on finding of the point mutations in the candidate cDNA linked with pedigrees with early-onset familial AD. We present evidence of its physical genome mapping of PS-1 by fluorescence in situ hybridization method.
Takano
T
T
Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan.
Yamanouchi
Y
Y
Sahara
N
N
Shirasawa
T
T
Mori
H
H
D000544:Alzheimer Disease / Q000235:genetics*; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D005796:Genes; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008565:Membrane Proteins / Q000235:genetics*; D053764:Presenilin-1
D008565:Membrane Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1