Dendritic calcium channels and hippocampal long-term depression.
The authors examine the potential role of the different sources of dendritic Ca2+ influx in long-term depression (LTD) of synaptic efficacy. Recent data on the location and functional distribution of voltage-gated Ca2+ channels obtained from fluorescence imaging and patch clamp experiments are presented. This is followed by a discussion of the existing evidence for different sources of Ca2+ playing a role in the induction of LTD. The authors conclude that a number of key issues need to be resolved before any conclusions are drawn as to the involvement of any specific route of Ca2+ entry in LTD.
Christie
B R
BR
Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA.
Magee
J C
JC
Johnston
D
D
D000818:Animals; D015220:Calcium Channels / Q000378:metabolism*; D003712:Dendrites / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*
D015220:Calcium Channels