title: Fotemustine in patients with advanced gastric cancer, a phase II trial from the EORTC-GITCCG (European Organization for Research and Treatment of Cancer, Gastrointestinal Tract Cancer Cooperative Group).
abstract: Fotemustine activity was evaluated in 26 patients, mostly pretreated, with advanced gastric cancer. Its main toxicity was haematological with grade 3-4 neutropenia in 32% and grade 3-4 thrombocytopenia in 50% of the patients, complicated by 2 toxicity-related deaths due to haemorrhage. No complete or partial responses were observed in the 26 eligible patients and median survival was only 11 weeks. Fotemustine therefore has no activity in advanced gastric cancer.
authors.affiliation: Gastrointestinal Unit, Gustave Roussy Institute, Villejuif, France.
authors.forename: P
authors.initials: P
authors.lastname: Rougier
authors.forename: C
authors.initials: C
authors.lastname: van Pottelsberghe
authors.forename: T
authors.initials: T
authors.lastname: Kok
authors.forename: B
authors.initials: B
authors.lastname: Paillot
authors.forename: T
authors.initials: T
authors.lastname: Wagener
authors.forename: J
authors.initials: J
authors.lastname: De Greve
authors.forename: M C
authors.initials: MC
authors.lastname: Fabri
authors.forename: B
authors.initials: B
authors.lastname: Gerard
authors.forename: M
authors.initials: M
authors.lastname: Van Glabbeke
authors.forename: H
authors.initials: H
authors.lastname: Bleiberg
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006402:Hematologic Diseases / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D009607:Nitrosourea Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D009943:Organophosphorus Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D009607:Nitrosourea Compounds; D009943:Organophosphorus Compounds; C054368:fotemustine