title: In vitro evaluation of N-(fluoro)isopropyl norephedrine as potential cardiac imaging agents for PET.
abstract: N-Isopropylnorephedrine (INE) and N-fluoroisopropylnorephedrine (FINE) were found to have a poor affinity for either beta-adrenoceptors and the norepinephrine carrier protein. The low affinity of both compounds for Uptake-1 is probably due to the introduction of a bulky substituent on the nitrogen atom. It is concluded that INE and FINE cannot be used for cardiac imaging with PET.
authors.affiliation: Pet-Center, University of Groningen, Netherlands.
authors.forename: T J
authors.initials: TJ
authors.lastname: de Groot
authors.forename: C K
authors.initials: CK
authors.lastname: Buitenhuis
authors.forename: M
authors.initials: M
authors.lastname: Rutgers
authors.forename: A
authors.initials: A
authors.lastname: van Waarde
authors.forename: G M
authors.initials: GM
authors.lastname: Visser
authors.forename: L A
authors.initials: LA
authors.lastname: Smets
authors.forename: O E
authors.initials: OE
authors.lastname: Brodde
authors.forename: W
authors.initials: W
authors.lastname: Vaalburg
mesh_terms: D019797:3-Iodobenzylguanidine; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007462:Iodobenzenes / Q000378:metabolism; D008024:Ligands; D009206:Myocardium / Q000378:metabolism*; D016716:PC12 Cells; D010665:Phenylpropanolamine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D014055:Tomography, Emission-Computed; D014407:Tumor Cells, Cultured
chemical_list: D002352:Carrier Proteins; D007462:Iodobenzenes; D008024:Ligands; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; C103217:N-fluoroisopropylnorephedrine; D010665:Phenylpropanolamine; D019797:3-Iodobenzylguanidine