title: Inhibitory effects of short intravascular infusions of propionate on reticulo-rumen motility in the sheep.
abstract: The effect of short infusions into the hepatic portal vein of propionate on reticulo-rumen motility was examined in conscious sheep. Infusions of 10 min duration of propionate at 1-6 mmol.min-1 into the portal vein reduced the frequency and amplitude of reticulum and rumen contractions, especially the amplitude of rumen contractions. Inhibitory effects were not confined to the portal route and were also obtained via the jugular vein, carotid artery, coeliac artery and anterior mesenteric artery. Butyrate was also effective, but acetate much less so and NaCl almost without effect. The inhibitory responses remained after section of nerves to the liver. It appears unlikely the effects reflexly originate from the liver or are derived centrally.
authors.affiliation: Department of Biological Sciences, University of Waikato, Hamilton, New Zealand.
authors.forename: L M
authors.initials: LM
authors.lastname: McLeay
authors.forename: M A
authors.initials: MA
authors.lastname: Pass
mesh_terms: D000085:Acetates / Q000494:pharmacology; D000818:Animals; D002087:Butyrates / Q000494:pharmacology; D003714:Denervation; D004576:Electromyography; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006499:Hepatic Artery / Q000187:drug effects / Q000502:physiology; D007262:Infusions, Intravenous; D008099:Liver / Q000187:drug effects / Q000294:innervation; D011169:Portal Vein; D011422:Propionates / Q000494:pharmacology*; D012159:Reticulum / Q000187:drug effects*; D012417:Rumen / Q000187:drug effects*; D012756:Sheep
chemical_list: D000085:Acetates; D002087:Butyrates; D011422:Propionates