Postbinding functions of CD4 in HIV infection.
Several studies have suggested that the CD4 molecule, in addition to serving as the HIV receptor, may also be involved in postbinding events of HIV infection. The CD4 molecule has been shown to assume an altered conformation on the T-cell surface following HIV binding, which may be involved in these postbinding events.
Bachelder
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Dept of Medicine, Harvard Medical School, Beth Israel Hospital, Boston, MA 02215, USA. rbacheld@bih.harvard.edu
Letvin
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D015704:CD4 Antigens / Q000737:chemistry / Q000378:metabolism*; D006678:HIV / Q000254:growth & development; D015658:HIV Infections; D006801:Humans; D008954:Models, Biological; D011487:Protein Conformation; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000737:chemistry / Q000378:metabolism*
D015704:CD4 Antigens