Host-bacteria interactions in foreign body infections.
Persistent staphylococcal infections are a major medical problem, especially when they occur on implanted materials or intravascular catheters. This review describes some of the recently discovered molecular mechanisms of Staphylococcus aureus attachment to host proteins coating biomedical implants. These interactions involve specific surface proteins, called bacterial adhesins, that recognize specific domains of host proteins deposited on indwelling devices, such as fibronectin, fibrinogen, or fibrin. Elucidation of molecular mechanisms of S aureus adhesion to the different host proteins may lead to the development of specific inhibitors blocking attachment of S aureus, which may decrease the risk of bacterial colonization of indwelling devices.
François
P
P
Division of Infectious Diseases, University Hospital, Geneva, Switzerland.
Vaudaux
P
P
Foster
T J
TJ
Lew
D P
DP
D018829:Adhesins, Bacterial; D000818:Animals; D001422:Bacterial Adhesion / Q000502:physiology; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; D002408:Catheters, Indwelling / Q000382:microbiology*; D003428:Cross Infection; D005340:Fibrinogen; D006801:Humans; D019736:Prostheses and Implants / Q000382:microbiology*; D016459:Prosthesis-Related Infections; D013203:Staphylococcal Infections; D013211:Staphylococcus aureus / Q000472:pathogenicity*
D018829:Adhesins, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; C078635:fibronectin-binding proteins, bacterial; D005340:Fibrinogen