[Successful topical administration of cyclosporin A in pyoderma gangraenosum].
Therapy of pyoderma gangrenosum can be complicated by side effects of the various systemic therapies, including corticosteroids, azathioprin and cyclosporin A. In this paper we report on a 49-year-old patient presenting with recalcitrant pyoderma gangrenosum who was treated successfully by topical application of cyclosporin A. Cyclosporin A serum levels were always in the subtherapeutic range, and no side effects were observed.
Theissen
U
U
Hautklinik, Westfälischen Wilhelms-Universität, Münster.
Luger
T A
TA
Schwarz
T
T
D000287:Administration, Topical; D016572:Cyclosporine / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D008657:Metabolic Clearance Rate / Q000502:physiology; D008875:Middle Aged; D017511:Pyoderma Gangrenosum / Q000097:blood / Q000188:drug therapy* / Q000473:pathology
D007166:Immunosuppressive Agents; D016572:Cyclosporine