Adult Still's disease. Part II. Management, outcome, and prognostic factors.
METHODS
a multicenter study conducted in France identified 65 cases of adult Still's disease. Follow-up exceeded one year in 52 cases.


OBJECTIVE
were as follows: 1) to describe treatments used; 2) to analyze disease course patterns; 3) to study joint alterations; 4) to determine whether any characteristics present within the first six months of onset were of prognostic significance.


RESULTS
aspirin was ineffective. Indomethacin ensured satisfactory control in eight patients. Corticosteroid therapy was required in 88% of cases. Among patients followed up for more than one year, half developed radiologic joint alterations; 23% had monocyclic systemic disease, 38.5% had polycyclic systemic disease and 38.5% had chronic articular disease. More than half of the patients (58%) had more than one systemic flare. Polyarthritis at onset and involvement of the proximal limb joints were significantly predictive of chronic articular disease, whereas isolated arthralgia was predictive of monocyclic or polycyclic systemic disease. Oligoarthritis was not predictive of the outcome.


CONCLUSIONS
the knowledge that polyarthritis or proximal limb joint involvement within six months of onset is predictive of chronic joint disease may have important therapeutic implications.
Masson
C
C
Rheumatology Department, Angers, France.
Le Loët
X
X
Lioté
F
F
Renou
P
P
Dubost
J J
JJ
Boissier
M C
MC
Brithmer
L
L
Brégeon
C
C
Audran
M
M
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001175:Arthrography; D018450:Disease Progression; D006801:Humans; D011379:Prognosis; D016706:Still's Disease, Adult-Onset / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents