title: Synthesis of 6,6-dicarboxy-3,4-methano-L-proline, a new constrained glutamate analog endowed with neuroprotective properties.
abstract: 6,6-Dicarboxy-3,4-methano-L-proline (L-DCMP, 7) has been prepared by the rhodium(II)acetate dimer catalyzed decomposition of dimethyl diazomalonate in the presence of a 3,4-didehydroproline derivative. When evaluated against NMDA- and kainate-induced toxicity in cultured cortical neurons, L-DCMP (7) exhibited good neuroprotective activity.
authors.affiliation: Instituto di Chimica e Tecnologia del Farmaco, Universita degli Studi di Perugia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Marinozzi
authors.forename: B
authors.initials: B
authors.lastname: Natalini
authors.forename: G
authors.initials: G
authors.lastname: Costantino
authors.forename: R
authors.initials: R
authors.lastname: Pellicciari
authors.forename: V
authors.initials: V
authors.lastname: Bruno
authors.forename: F
authors.initials: F
authors.lastname: Nicoletti
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000187:drug effects; D005260:Female; D051379:Mice; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D011247:Pregnancy; D011392:Proline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D017470:Receptors, Glutamate / Q000187:drug effects
chemical_list: C098822:6,6-dicarboxy-3,4-methano-L-proline; D018696:Neuroprotective Agents; D017470:Receptors, Glutamate; D011392:Proline