title: Treatment choices of 119 patients with hemifacial spasm over 11 years.
abstract: A retrospective study of patients with hemifacial spasm (HFS) was performed in order to determine long-term treatment choices: local botulinum toxin, type A, injections, oral pharmacologic agents, and surgery (neurosurgical decompression of the seventh nerve at the brainstem level and upper eyelid blepharoplasty). Of 119 patients with diagnosed hemifacial spasm in the Oculoplastics Division of the Department of UMD-New Jersey Medical School, Newark, NJ from September, 1983, to June 1, 1994, 108 were initially treated with 735 botulinum toxin injections. Forty-seven of the 108 patients (43.5%) initially treated at our institution received 459 injections for a median treatment period of 59 months per patient. Eight patients (7.4%) continued treated elsewhere and four other patients were injected at our institution until their death from other causes. Twenty-two patients (20.4%) were lost to followup after receiving 117 injections. Five patients (4.6%) had spontaneous resolution of their condition after botulinum toxin therapy and nine patients (8.3%) chose not to receive any additional injections or other treatment. Thirteen patients (12.0%) did not respond adequately to botulinum injections and 10 such patients obtained relief from treatments other than botulinum toxin: oral pharmacologic agents (two patients), neurosurgical decompression of the seventh nerve (two patients), and upper eyelid blepharoplasty (one patient). In addition to botulinum injections, 15 patients required adjunctive minor tranquilizers and/or antiseizure medications. Botulinum A toxin is an excellent long-term treatment of hemifacial spasm. This condition may occasionally spontaneously resolve after botulinum therapy.
authors.affiliation: Department of Ophthalmology, UMD-New Jersey Medical School, Newark 07103-2499, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Mauriello
authors.forename: T
authors.initials: T
authors.lastname: Leone
authors.forename: S
authors.initials: S
authors.lastname: Dhillon
authors.forename: B
authors.initials: B
authors.lastname: Pakeman
authors.forename: R
authors.initials: R
authors.lastname: Mostafavi
authors.forename: M C
authors.initials: MC
authors.lastname: Yepez
mesh_terms: D017668:Age of Onset; D000368:Aged; D001764:Blepharospasm / Q000188:drug therapy / Q000503:physiopathology*; D001905:Botulinum Toxins / Q000008:administration & dosage / Q000627:therapeutic use; D005154:Facial Nerve / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D001905:Botulinum Toxins