Epidemiology and clinical management of endometrial carcinoma in the Republic of Georgia in the last 30 years.
Endometrial carcinoma incidence in Georgia from 1965 to 1992 was 5.3 women per 100,000 and in the structure of gynecological malignant tumors this pathology occupied third place (19.1%). Morbidity incidence varied from 2 to 8 depending on ethnic regions overall a 2.5 times rise in morbidity was observed. Within the period of 1968-1994 1731 patients with uterine carcinoma were subjected to surgical intervention (stage I-81.2%; stage II-9.4%; stage III-9.0%; stage IV-0.3%). Surgical intervention is the optimal method to determine the stage of the disease and planning of adjuvant treatment. Metastases in regional lymph nodes were found in 13.0% (T1-7.7%; T2-20.07%; T3-35.3%). Adenocarcinoma was histologically confirmed in 97.4% (G1-21.3%; G2-57.8%; G3-18.8%). Management of the disease was predominantly started with surgical intervention. In pathogenetic version I (71.4%) total extirpation of the uterine was carried out, while in cases of the pathogenetic version II (28.6%) patients were subjected to the modified extended extirpation. Postoperative management was prescribed based on the peculiarities of the organism and tumor. Highly sensitive classification of endometrial carcinoma of stage I (including 5 subgroups) as well as a synoptic table of optimal management were worked out. As a result, 5 year survival increased by 15%, and 29% of the women operated were spared from additional treatment. On the whole, five-year-survival was observed in 71.0% of women (stage I-77.7%; Early Form-95.5%; stage II-51.5%; stage III-34.2%).
Charkviani
T
T
Oncologic Scientific Center Gynecologic Institute Tbilisi, Republic of Georgia.
Charkviani
L
L
Chitiashvili
R
R
Glonti
L
L
D016889:Endometrial Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy; D005260:Female; D005846:Georgia (Republic) / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D016019:Survival Analysis