Blood glucose normalization-induced haemolysis in three adolescents with type 1 diabetes mellitus at onset and unknown G-6-PD deficiency.
We present three adolescents unknown to be G-6-PD deficient who developed haemolytic anaemia after admission for diabetes at onset uncomplicated by ketoacidosis. These patients had no bacterial infections and had not ingested haemolytic drugs. The fall in glucose availability after the correction of hyperglycaemia is proposed as capable of inducing haemolysis in G-6-PD deficiency.
Vanelli
M
M
Department of Paediatrics, University of Parma, Italy.
Lucentini
L
L
Picco
P
P
Galanello
R
R
Chiari
G
G
Adinolfi
B
B
Street
M E
ME
D000293:Adolescent; D000743:Anemia, Hemolytic / Q000209:etiology*; D001786:Blood Glucose / Q000378:metabolism*; D002648:Child; D004252:DNA Mutational Analysis; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D006029:Glycosuria; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use; D007657:Ketone Bodies / Q000652:urine; D008297:Male
D001786:Blood Glucose; D007328:Insulin; D007657:Ketone Bodies