Pharmacokinetic evaluation of omeprazole suspension following oral administration in rats: effect of neutralization of gastric acid.
In order to evaluate a clinical use of omeprazole suspension, we examined the pharmacokinetics of omeprazole after oral administration in rats. Although the administration of omeprazole suspension buffered by NaHCO3 solution did not produce a significant increase in the area under the concentration-time curve (AUC) value compared with non-buffered group, the administration of NaHCO3 buffer immediately after dosing of omeprazole suspension buffered by NaHCO3 caused a significant increase in the AUC value. These results suggest that the NaHCO3 treatment following the administration of omeprazole buffered suspension effectively decreased the degradation of the compound by gastric acid. Therefore, the successive administration of NaHCO3 solution after the omeprazole dosing seems to be a simple and useful method for the administration to patients who cannot receive tablets.
Watanabe
K
K
Department of Hospital Pharmacy, Okayama University Medical School, Japan.
Matsuka
N
N
Furuno
K
K
Eto
K
K
Kawasaki
H
H
Gomita
Y
Y
D000284:Administration, Oral; D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D008297:Male; D009853:Omeprazole / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D017693:Sodium Bicarbonate / Q000008:administration & dosage*
D017693:Sodium Bicarbonate; D009853:Omeprazole