Interleukin-1 but not tumour necrosis factor alpha synergistically upregulates the granulocyte-macrophage colony-stimulating factor-induced B7-1 expression of murine Langerhans cells.
Epidermal Langerhans cells (LC) express several co-stimulatory molecules such as B7/BB1, which has been implicated as one of the important determinants for potent antigen-presenting function of LC. Recent studies have shown that B7/BB1 antigens comprise three distinct molecules termed B7-1, B7-2 and B7-3. Previous studies have revealed that the phenotypic and functional properties of murine LC are enormously affected by various cytokines including granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin-1 (IL-1), and tumour necrosis factor alpha (TNF-alpha) derived from surrounding keratinocytes. We have already demonstrated that the expression of B7-1 of murine LC is significantly enhanced by GM-CSF, IL-1 or TNF-alpha. In this paper, we present that IL-1, but not TNF-alpha, synergistically up-regulates the GM-CSF-induced B7-1 expression of murine LC.
Furue
M
M
Department of Dermatology, Tokyo University Branch Hospital, Japan.
Chang
C H
CH
Tamaki
K
K
D000818:Animals; D018122:B7-1 Antigen / Q000032:analysis / Q000378:metabolism*; D002478:Cells, Cultured; D005260:Female; D005455:Fluorescent Antibody Technique; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000493:pharmacokinetics / Q000502:physiology*; D007375:Interleukin-1 / Q000493:pharmacokinetics / Q000502:physiology*; D007801:Langerhans Cells / Q000378:metabolism*; D051379:Mice; D008809:Mice, Inbred C3H; D014409:Tumor Necrosis Factor-alpha / Q000493:pharmacokinetics / Q000502:physiology*; D015854:Up-Regulation
D018122:B7-1 Antigen; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D016178:Granulocyte-Macrophage Colony-Stimulating Factor