5-year follow-up of patients successfully transplanted after immunoadsorption to remove anti-HLA antibodies.
The function of renal allografts in patients who had received pretransplant immunoadsorption in order to remove cytotoxic anti-HLA antibodies was studied. We reviewed 6 patients who received a graft which functioned beyond 3 months; the mean follow-up period was 76 (range 62-89) months. Two grafts have been lost from chronic rejection, at 12 and 62 months, respectively. The mean plasma creatinine levels at 1 and 5 years were 169 (range 143-211) mumol/l and 155 (range 92-235) mumol/l, respectively (1.91, range 1.62-2.39, mg/dl and 1.75, range 1.04-2.66 mg/dl, respectively). The major source of morbidity during long-term follow-up has been the occurrence of renal artery stenosis in 5 patient and renal vein stenosis in 1. In conclusion, the 5-year graft survival and function was good in patients who received immunoadsorption and whose grafts survived beyond the first 3 months after transplantation.
Higgins
R M
RM
Department of Medicine, King's College School of Medicine and Dentistry, London, UK.
Bevan
D J
DJ
Vaughan
R W
RW
Phillips
A O
AO
Snowden
S
S
Bewick
M
M
Scoble
J E
JE
Hendry
B M
BM
D000368:Aged; D000369:Aged, 80 and over; D001157:Arterial Occlusive Diseases / Q000150:complications; D001323:Autoantibodies / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007164:Immunosorbents / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic / Q000276:immunology* / Q000401:mortality / Q000601:surgery; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012077:Renal Artery / Q000473:pathology; D012082:Renal Veins / Q000473:pathology; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome
D001323:Autoantibodies; D006680:HLA Antigens; D007164:Immunosorbents