Absorption of topically administered ciprofloxacin, ofloxacin and gentamicin in the inflamed rabbit eye.
The authors evaluated the ocular absorption of ciprofloxacin, ofloxacin and gentamicin as a reference drug in a novel model of ocular inflammation. The ocular absorption of ciprofloxacin and ofloxacin was shown to be increased two- to threefold in the inflamed eye. The absorption of gentamicin was undetectable in the normal eye and very poor in the inflamed eye.
Behrens-Baumann
W
W
Universitats-Augenklinik der Otto-von-Guericke-Universitat Magdeburg, Deutschland.
D000042:Absorption; D000287:Administration, Topical; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001082:Aqueous Humor / Q000378:metabolism; D018916:Blood-Aqueous Barrier; D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003315:Cornea / Q000378:metabolism; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005839:Gentamicins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007262:Infusions, Intravenous; D007634:Keratitis / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D015242:Ofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D009883:Ophthalmic Solutions; D011817:Rabbits
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D005839:Gentamicins; D009883:Ophthalmic Solutions; D002939:Ciprofloxacin; D015242:Ofloxacin