title: Synthesis and antiinflammatory activity of some imidazolinylpyrazole derivatives.
abstract: Some new imidazolinyl-pyrazoles (4) were synthesized by condensation of 2-imidazolylhydrazine hydroiodid (1a) with beta-ketoesters to afford the intermediate 3 that, as free base, ring closes only to 4. The attempt to obtain the imidazo-triazepinone 5, starting from 2-imidazolinyl-2-methylhydrazine, was accomplished, in low yield, only in reacting with ethyl acetoacetate. The pharmacological evaluation of antiinflammatory and analgesic activities of pyrazoles 4a-f revealed an appreciable antiinflammatory activity.
authors.affiliation: Istituto di Scienze Farmaceutiche, Universita di Genova, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Savelli
authors.forename: A
authors.initials: A
authors.lastname: Boido
authors.forename: M
authors.initials: M
authors.lastname: Satta
authors.forename: A
authors.initials: A
authors.lastname: Peana
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000893:Anti-Inflammatory Agents; D011720:Pyrazoles