title: An NMR self-diffusion study of the interactions between spermidine and oligonucleotides.
abstract: Self-diffusion coefficients have been determined by pulsed field gradient nmr methods for spermidine in solutions of the oligonucleotides d(GC)4 and d(GGAATTCC). The self-diffusion behavior of spermidine in solution of d(GC)4 is very similar to that observed previously for methylspermidine (completely N-methylated spermidine). Moreover, the self-diffusion behaviors of spermidine in solutions of d(GC)4 and d(GGAATTCC) are also quite similar, indicating that there is no significant influenceon on self-diffusion of oligonucleotide base composition. Furthermore, self-diffusion coefficients of the oligonucleotide d(GC)8 show only a small dependence on oligonucleotide concentration, and no measurable dependence on sodium ion or magnesium ion concentration.
authors.affiliation: Division of Physical Chemistry, Stockholm University, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Andreasson
authors.forename: L
authors.initials: L
authors.lastname: Nordenskiöld
authors.forename: W H
authors.initials: WH
authors.lastname: Braunlin
mesh_terms: D001483:Base Sequence; D004058:Diffusion; D004347:Drug Interactions; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008969:Molecular Sequence Data; D009841:Oligonucleotides / Q000737:chemistry*; D013095:Spermidine / Q000737:chemistry*
chemical_list: D009841:Oligonucleotides; D013095:Spermidine