Haemoglobin A(1c) measurement for diabetes among subjects with a previous history of impaired glucose tolerance.
Haemoglobin A(1c) (HbA(1c)) measurement for diagnosis of diabetes and impaired glucose tolerance (IGT) was assessed during a prospective study of subjects with IGT; 183 of the 207 IGT persons underwent the second oral glucose tolerance tests (OGTT) 2.1 years, on the average, after the first tests. HbA(1c) was administered to every participant before the second OGTTs. The results of HbA(1c) were compared with those of the second OGTTs. The sensitivity of HbA(1c) test was 71% for diabetes and 41% for IGT, when the specificity was 93% at a cutoff point of 4.81%. The conclusion is that the HbA(1c) test is moderately sensitive for diabetes but insensitive for IGT, when it is specific. However, it may be useful for selecting and reducing the total number of subjects referred to 2-h OGTTs in a follow-up study of subjects with IGT, if the rate of progression to diabetes is not high.
Qiao
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Department of Public Health Science and General Practice, Aapistie, Oulu, Finland.
Keinänen-Kukaanniemi
Kivelä
S L
SL
D015415:Biomarkers / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis*; D005260:Female; D005387:Finland; D005500:Follow-Up Studies; D018149:Glucose Intolerance / Q000097:blood / Q000175:diagnosis*; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012372:ROC Curve; D012680:Sensitivity and Specificity
D015415:Biomarkers; D006442:Glycated Hemoglobin