Experimental study on necrotizing sialometaplasia of the palate in rats. Role of local anesthetic injections.
The effect of local anesthetic injections in the palate of rats was studied by light microscopy and immunohistochemistry with antibody to proliferating cell nuclear antigen (PCNA). The results of this study suggest that local anesthetic injections could be one of the causes of necrotizing sialometaplasia.
Shigematsu
H
H
2nd Department of Oral and Maxillofacial Surgery, Meikai University School of Dentistry Sakado, Saitama, Japan.
Shigematsu
Y
Y
Noguchi
Y
Y
Fujita
K
K
D000772:Anesthesia, Local / Q000009:adverse effects*; D000779:Anesthetics, Local / Q000009:adverse effects*; D000818:Animals; D004848:Epithelium / Q000473:pathology; D006965:Hyperplasia; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D007267:Injections / Q000009:adverse effects; D008012:Lidocaine / Q000009:adverse effects*; D008297:Male; D008679:Metaplasia; D010159:Palate / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D018987:Salivary Ducts / Q000473:pathology; D012470:Salivary Glands, Minor / Q000473:pathology; D012797:Sialometaplasia, Necrotizing / Q000139:chemically induced / Q000209:etiology*
D000779:Anesthetics, Local; D018809:Proliferating Cell Nuclear Antigen; D008012:Lidocaine