title: Complement activation during and after open-heart surgery is only marginally affected by the choice of fluid for volume replacement.
abstract: Forty patients undergoing CPB for coronary artery surgery, using a standardized technical setting, were randomized to receive either Ringer's acetate, dextran 70 (Macrodex), polygeline (Haemaccel) or albumin 4% for volume replacement during and after surgery. The choice of fluid did not affect early complement activation (C3 activation products). Higher values of the terminal complement complex (TCC) were found only at the end of the operation in patients receiving polygeline. There were no differences between any two of the four groups during the postoperative course. The use of blood transfusion or autotransfusion and the degree of haemodilution and hypothermia did not affect complement activation. We conclude that complement activation in association with open-heart surgery is only marginally affected by the choice of fluid for volume replacement.
authors.affiliation: Department of Surgery A, Rikshospitalet, University of Oslo, Norway.
authors.forename: J L
authors.initials: JL
authors.lastname: Svennevig
authors.forename: S
authors.initials: S
authors.lastname: Tølløfsrud
authors.forename: U
authors.initials: U
authors.lastname: Kongsgaard
authors.forename: H
authors.initials: H
authors.lastname: Noddeland
authors.forename: B
authors.initials: B
authors.lastname: Mohr
authors.forename: M
authors.initials: M
authors.lastname: Ozer
authors.forename: T E
authors.initials: TE
authors.lastname: Mollnes
mesh_terms: D000328:Adult; D000368:Aged; D001803:Blood Transfusion; D002315:Cardiopulmonary Bypass; D003167:Complement Activation; D003176:Complement C3 / Q000378:metabolism; D015938:Complement Membrane Attack Complex / Q000378:metabolism; D001026:Coronary Artery Bypass; D005260:Female; D006438:Hemodilution; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D003176:Complement C3; D015938:Complement Membrane Attack Complex