title: Effect of a combination of antimicrobial agents for the treatment of respiratory disease in cattle.
abstract: Clinical effect of the administration of thiamphenicol (TP) and tylosin (TS) on bovine respiratory disease was investigated. Group I (n = 64) were administered TP (10 mg/kg) and TS (4 mg/kg), group II (n = 26) were given TP (5 mg/kg) and TS (2 mg/kg). For the control, TP group (n = 25) were given 20 mg/kg of TP and ampicillin group (n = 23) were given 10 mg/kg of ampicillin. As a result, improvement of clinical findings was more rapid and the cure rate was significantly higher in group I compared to those in the other 3 groups. These results showed that a combination therapy with minimal basic doses of TP and TS is very effective for some respiratory diseases in cattle.
authors.affiliation: Veterinary Clinical Training Center, Yamagata Prefectural Federation of Agricultural Mutual Aid Associations, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Katoh
authors.forename: J
authors.initials: J
authors.lastname: Sakai
authors.forename: Y
authors.initials: Y
authors.lastname: Ogata
authors.forename: Y
authors.initials: Y
authors.lastname: Urushiyama
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D016978:Mannheimia haemolytica / Q000302:isolation & purification; D009174:Mycoplasma / Q000302:isolation & purification; D009175:Mycoplasma Infections / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D010326:Pasteurella Infections / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D016979:Pasteurella multocida / Q000302:isolation & purification; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D013839:Thiamphenicol / Q000627:therapeutic use*; D013997:Time Factors; D015645:Tylosin / Q000627:therapeutic use*
chemical_list: D013839:Thiamphenicol; D015645:Tylosin