[Immunotherapy of tumors expressing IGF-I].
Recently we demonstrated that rat glioma cells when transfected with a vector encoding antisense IGF-I c-DNA lost tumorigenicity and induced a tumor specific immune response involving CD8+ lymphocytes. Here we showed, using immunostaining flow cytometry analysis, that the transfected cell lines, rat C-6 glioma and rat LF hepatoma, expressed an increase level of MHC-class I, and even the amount of MHC-I was found to be higher in the transfected hepatoma, than in the transfected glioma cells. This increased expression of MHC-I could contribute to the final immune recognition of tumour immunogenicity.
Trojan
J
J
Centre Hépato-Biliaire, Université Paris-Sud, Villejuif, France.
Duc
H T
HT
Lafarge-Frayssinet
C
C
Upegui-Gonzales
L C
LC
Swiercz
B
B
Bismuth
H
H
Hor
F
F
Anthony
D
D
Guo
Y
Y
Ilan
J
J
D000818:Animals; D016373:DNA, Antisense / Q000235:genetics; D005910:Glioma / Q000235:genetics / Q000628:therapy*; D007167:Immunotherapy; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008114:Liver Neoplasms, Experimental / Q000235:genetics / Q000628:therapy*; D051381:Rats; D014162:Transfection
D016373:DNA, Antisense; D007334:Insulin-Like Growth Factor I