Comparison of the association with eczema herpeticum in the two predominant genotypes of herpes simplex virus type 1.
Eczema herpeticum, sometimes called Kaposi's varicelliform eruption, is usually caused by a disseminated herpes simplex virus infection in a patient whose underlying skin disease in atopic dermatitis. Herpes simplex virus type 1 (HSV-1), a widespread infectious agent in human populations, is the etiologic agent of eczema herpeticum. Analyses of restriction fragment length polymorphism (RFLP) of HSV-1 strains isolated in Japan, using restriction endonucleases, revealed the presence of two predominant genotypes of F1 and F35. The number of HSV-1 strains of F1 genotype was over twice that of the F35 genotype, and the nucleotide change between F1 and F35 was estimated to be 1.5%. The question of whether the genomic difference between two predominant genotypes could influence clinical manifestations remained to be addressed. On the basis of RFLP, we determined genotypes of HSV-1 strains isolated from the patients in Japan, including those with eczema herpeticum. Two of four HSV-1 strains of F35 genotype were from patients with eczema herpeticum, whereas none of 12 HSV-1 strains of F1 genotype was from those with eczema herpeticum. Thus, the F35 genotype seemed to be associated more frequently with eczema herpeticum than the F1 genotype.
Umene
K
K
Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Yoshida
M
M
Sakaoka
H
H
D000818:Animals; D002522:Chlorocebus aethiops; D004279:DNA, Viral / Q000032:analysis*; D005838:Genotype; D018259:Herpesvirus 1, Human / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007617:Kaposi Varicelliform Eruption / Q000821:virology*; D012150:Polymorphism, Restriction Fragment Length; D014709:Vero Cells
D004279:DNA, Viral