Emblica officinalis: a novel therapy for acute pancreatitis--an experimental study.
Acute necrotising pancreatitis is associated with an unacceptably high mortality for which no satisfactory remedy exists. Emblica officinalis (E.o.) is a plant prescribed in Ayurveda, the Indian traditional system of medicine, for pancreas-related disorders. This study was carried out to evaluate the protective effect of E.o. against acute necrotising pancreatitis in dogs. Pancreatitis was induced by injecting a mixture of trypsin, bile and blood into the duodenal opening of the pancreatic duct. Twenty eight dogs were divided into 4 groups (n = 6-8 each): GpI--control, GpII--acute pancreatitis, GpIII--sham-operated, GpIV--pretreatment with 28 mg E.o./kg/day for 15 days before inducing pancreatitis. Serum amylase increased from 541.99 +/- 129.13 IU/ml to 1592.63 +/- 327.83 IU (p <0.02) 2 hrs after the induction of pancreatitis in GpII. The rise in serum amylase in both GpIII and GpIV was not significant. On light microscopic examination, acinar cell damage was less and the total inflammatory score was significantly lower in the E.o. treated group as compared to GpII. Electron microscopy confirmed this and showed an increased amount of smooth endoplasmic reticulum and small, condensed granules embedded in a vacuole. More studies are needed to explore the clinical potential of E.o. and its mechanism of action.
Thorat
S P
SP
Department of Pharmacology, Seth G. S. Medical College, Bombay, India.
Rege
N N
NN
Naik
A S
AS
Thatte
U M
UM
Joshi
A
A
Panicker
K N
KN
Bapat
R D
RD
Dahanukar
S A
SA
D000208:Acute Disease; D000681:Amylases / Q000097:blood; D000818:Animals; D004285:Dogs; D005260:Female; D008297:Male; D008518:Medicine, East Asian Traditional; D008854:Microscopy, Electron; D010195:Pancreatitis / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D010936:Plant Extracts / Q000008:administration & dosage*; D016896:Treatment Outcome
D010936:Plant Extracts; D000681:Amylases