title: Macrocarpals H, I, and J from the Leaves of Eucalyptus globulus.
abstract: A 50% EtOH extract of Eucalyptus globulus leaves yielded eight phloroglucinol--sesquiterpene-coupled constituents, including three novel compounds named macrocarpals, H, I, and J. Some of these compounds possessed antibacterial activity against oral pathogenic microorganisms with MIC values ranging from 0.20 micrograms/mL to 6.25 micrograms/mL. Inhibition of glucosyltransferase activity by these compounds was also noted.
authors.affiliation: Department of Basic Research, Lotte Central Laboratory Co, Ltd., Saitama, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Osawa
authors.forename: H
authors.initials: H
authors.lastname: Yasuda
authors.forename: H
authors.initials: H
authors.lastname: Morita
authors.forename: K
authors.initials: K
authors.lastname: Takeya
authors.forename: H
authors.initials: H
authors.lastname: Itokawa
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005052:Eucalyptus / Q000737:chemistry*; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D010696:Phloroglucinol / Q000031:analogs & derivatives; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry*; D010946:Plants, Medicinal; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D012717:Sesquiterpenes; C102709:macrocarpal H; C102710:macrocarpal I; C102711:macrocarpal J; D010696:Phloroglucinol; D005964:Glucosyltransferases