title: Once-daily aminoglycoside therapy: potential ototoxicity.
abstract: Current data indicate that once-daily aminoglycoside therapy is as efficacious as traditional multiple daily dosing and equally or less toxic. Our experience with once-daily gentamicin, 6 mg/kg of body weight led to a 10% (3 of 33 patients) occurrence of documented ototoxicity after prolonged aminoglycoside exposure.
authors.affiliation: Department of Medicine, Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA.
authors.forename: C
authors.initials: C
authors.lastname: Singer
authors.forename: C
authors.initials: C
authors.lastname: Smith
authors.forename: D
authors.initials: D
authors.lastname: Krieff
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D004244:Dizziness / Q000139:chemically induced; D004427:Ear Diseases / Q000139:chemically induced*; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins