title: Virulence-associated characteristics and phage lysogenicity of two morphologically distinct colonies of Vibrio cholerae O139 serogroup.
abstract: The presence of a temperate phage was demonstrated in a strain of Vibrio cholerae O139 isolated from a patient. Spontaneous variants with translucent colonies had lost this phage. The loss of the phage was associated with increased hydrophobicity, indicating the loss of the capsule. These clones were sensitive to serum bactericidal activity, showed decreased expression of such presumed virulence factors as proteases, motility and mannose-sensitive pili. Furthermore, excision of the phage made the strain dependent on purines for growth.
authors.affiliation: Department of Genetics, Russian Antiplague Research Institute, Microbe, Russia.
authors.forename: N I
authors.initials: NI
authors.lastname: Smirnova
authors.forename: G V
authors.initials: GV
authors.lastname: Chekhovskaya
authors.forename: N I
authors.initials: NI
authors.lastname: Davidova
authors.forename: L F
authors.initials: LF
authors.lastname: Livanova
authors.forename: G A
authors.initials: GA
authors.lastname: Yeroshenko
mesh_terms: D000818:Animals; D016667:Bacterial Capsules / Q000502:physiology; D002876:Chromosomes, Bacterial / Q000821:virology; D015169:Colony Count, Microbial; D007928:Lethal Dose 50; D008242:Lysogeny / Q000502:physiology*; D051379:Mice; D014734:Vibrio cholerae / Q000254:growth & development / Q000472:pathogenicity* / Q000821:virology; D014774:Virulence