New bioactive cerebrosides from Arisaema amurense.
From Arisaema amurense, four new cerebrosides were isolated along with a known cerebroside. The new cerebrosides were characterized as 1-O-beta-D-glucopyranosyl- (2S,3R,4E,8Z)-2-[(2(R)- hydroxyicosanoyl)amido]-4,8-octadecadiene-1,3-diol (1), 1-O-beta-D- glucopyranosyl-(2S,3R,4E,8Z)- 2-[(2-hydroxyoctadecanoyl)amido]-4,8-octadecadiene-1,3-diol (2), 1-O-beta-D- glucopyranosyl- (2S,3R,4E,8E)-2-[(2-hydroxyicosanoyl)amido]-4,8-oct adecadiene-1,3-diol (4), and 1-O-beta-D- glucopyranosyl-(2S,3R,4E,8E)-2-[(2-hydroxyoctadecanoyl )amido]-4,8- octadecadiene-1,3-diol (5), respectively. These cerebrosides displayed significant antihepatotoxic activity.
Jung
J H
JH
Korea Ocean Research & Development Institute, Seoul.
Lee
C O
CO
Kim
Y C
YC
Kang
S S
SS
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy / Q000201:enzymology; D002554:Cerebrosides / Q000302:isolation & purification* / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000201:enzymology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007723:Korea; D007064:L-Iditol 2-Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000166:cytology / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D002554:Cerebrosides; D007064:L-Iditol 2-Dehydrogenase; D001219:Aspartate Aminotransferases