The efficacy of fluoxetine in the treatment of premature ejaculation: a double-blind placebo controlled study.
OBJECTIVE
The efficacy of the selective serotonin re-uptake inhibitor fluoxetine in the treatment of premature ejaculation was examined.


METHODS
The study comprised 17 patients with premature ejaculation who presented to the urology clinic of our medical school. In this double-blind study the patients were randomized into treatment groups receiving 20 mg. fluoxetine daily for 1 week and 40 mg. daily afterward (group 1) or 1 capsule placebo daily for 1 week and 2 capsules daily afterward (group 2). The groups were evaluated according to the latent period of intravaginal ejaculation.


RESULTS
The latent period of intravaginal ejaculation in group 1 was significantly longer than that in group 2. Nausea, headache and insomnia were reported side effects.


CONCLUSIONS
Fluoxetine may be regarded as a safe and effective alternative in the treatment of premature ejaculation.
Kara
H
H
Department of Psychiatry, Medical School of Yüzüncü Yil University, Van, Turkey.
Aydin
S
S
Yücel
M
M
Agargün
M Y
MY
Odabaş
O
O
Yilmaz
Y
Y
D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D004542:Ejaculation / Q000187:drug effects*; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D013997:Time Factors
D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors