Salivary monoamine oxidase A and B inhibitory activities correlate with stress.
MAO A and B inhibitory activities were determined, for the first time, in saliva samples. Saliva was collected on 4 occasions from 11 normal subjects (students) before and after delivering an important assessed oral presentation, a naturalistic stress inducing procedure. The first sample was collected 30 minutes before the presentation and 3 more within 40 minutes of finishing the presentation. At each collection a mood adjective checklist was completed. Mean MAO A inhibitory activity correlated with mean MAO B inhibitory activity (r = 0.872, p < 0.001, n = 11). Within subject analysis revealed a positive correlation between MAO A and B inhibitory activity and stress (r = 0.400, p < 0.01, n = 44 and r = 0.255, NS, n = 38 respectively). Mean MAO A and B inhibitory activity correlated with mean stress (r = 0.535, NS, n = 11 and r = 0.673, p < 0.05, n = 11 respectively). Peak MAO A and B inhibitory activities correlated with peak stress (r = 0.636, p < 0.05, n = 11 and r = 0.754, p < 0.01, n = 11, respectively). Salivary MAO A and B inhibitory activities were independent of salivary flow rate. We conclude that measurement of MAO A and B inhibitory activities in saliva is preferable to traditional urinary measures as sampling is less invasive and also supports a clear relationship to stress in normal individuals.
Doyle
A
A
Psychophysiology and Stress Research Group, School of Biological and Health Sciences, University of Westminster, London, United Kingdom.
Hucklebridge
F
F
Evans
P
P
Clow
A
A
D005260:Female; D006801:Humans; D007510:Isatin; D007527:Isoenzymes / Q000378:metabolism*; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000378:metabolism*; D012463:Saliva / Q000378:metabolism*; D013315:Stress, Psychological / Q000201:enzymology / Q000378:metabolism*
D007527:Isoenzymes; D008996:Monoamine Oxidase Inhibitors; D007510:Isatin; C039776:tribulin; D008995:Monoamine Oxidase