title: Biogenesis of hepatic acute-phase response to trauma.
abstract: The bioorganic pathway(s) of hepatic acute-phase response in rat to single and compounded traumata triggered either by chemical or physical injury has been re-evaluated for the purpose of advancing a better understanding of mechanisms of hepatic regeneration. These insights would be useful in cases of liver cirrhosis and end-stage liver diseases and may allow avenues of surgical management other than liver transplantation. Mechanisms of acute-phase response in rat to a single inflammatory stimulus, e.g. intoxication with phalloidin, alpha-amanitin, subcutaneous administration of carageenan, subcutaneous implantation of Yoshida sarcoma or i.p. administration of Zajdela ascites are discussed and compared with (a) acute-phase response to intoxication by various factors leading to the development of liver cirrhosis, and (b) acute-phase response of nascent hepatocytes where hepatic regenerative activities were induced by chemical intoxication or surgical partial hepatectomy. Interestingly, hepatic acute-phase response was not limited only to these injuries outlined above but also to psychological conditions.
authors.affiliation: Biomedical Mass Spectrometry Unit, McGill University, Montreal, Quebec, Canada.
authors.forename: F M
authors.initials: FM
authors.lastname: Fouad
authors.forename: O A
authors.initials: OA
authors.lastname: Mamer
authors.forename: F
authors.initials: F
authors.lastname: Shahidi
mesh_terms: D000209:Acute-Phase Proteins / Q000096:biosynthesis*; D000818:Animals; D001379:Azathioprine; D001798:Blood Proteins / Q000096:biosynthesis; D002252:Carbon Tetrachloride Poisoning / Q000503:physiopathology; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000503:physiopathology / Q000601:surgery; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000503:physiopathology; D017093:Liver Failure / Q000503:physiopathology / Q000601:surgery; D016031:Liver Transplantation; D051381:Rats; D014947:Wounds and Injuries / Q000378:metabolism / Q000503:physiopathology
chemical_list: D000209:Acute-Phase Proteins; D001798:Blood Proteins; D001379:Azathioprine