title: The multiple roles of transcription/repair factor TFIIH.
abstract: TFIIH is by far the most complex of the basal RNA polymerase II transcription factors. It is a protein kinase, a bi-directional DNA helicase and is essential for both transcription and nucleotide excision repair (NER). Furthermore, the factor can activate cyclin-dependent kinases and so might play a role in cell-cycle regulation. The recent elucidation of the subunit composition of TFIIH has shown an extraordinary conservation of its structure from yeast to human.
authors.affiliation: ICRF Clare Hall Laboratories, South Mimms, UK.
authors.forename: J Q
authors.initials: JQ
authors.lastname: Svejstrup
authors.forename: P
authors.initials: P
authors.lastname: Vichi
authors.forename: J M
authors.initials: JM
authors.lastname: Egly
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001665:Binding Sites; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D004265:DNA Helicases / Q000378:metabolism; D004260:DNA Repair; D004789:Enzyme Activation; D006801:Humans; D010766:Phosphorylation; D012319:RNA Polymerase II / Q000378:metabolism; D051758:Transcription Factor TFIIH; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D019473:Transcription Factors, TFII; D014158:Transcription, Genetic
chemical_list: D014157:Transcription Factors; D019473:Transcription Factors, TFII; C066644:transcription factor TFIIE; D051758:Transcription Factor TFIIH; D000255:Adenosine Triphosphate; D018844:Cyclin-Dependent Kinases; D012319:RNA Polymerase II; D004265:DNA Helicases