[Solitary capillary hemangioblastoma, cellular variant. Clinical, radiological, and anatomo-pathological study of 2 cases].
Two cases of the rare cellular variant of the solitary capillary haemangioblastoma are reported. On MR study both tumors appeared as cerebellar contrast-enhancing masses, without evidence of intra- or perilesional blood vessels. Histologically, they showed compact groups of polygonal or rectangular cells separated by compressed small capillaries. There were no reticulin fibres among cell clusters. The stromal cells were found to be immunopositive for neuron-specific enolase (NSE), factor VIII-related antigen (von Wille-brand factor), Ulex europaeus lectin, and glial frillary acidic protein (GFAP). The findings are discussed in light of the pertinent literature.
Del Basso De Caro
M
M
Istituto di Patologia, Università di Napoli, Federico II.
De Stefano
V
V
Bucciero
A
A
Iaconetta
G
G
Cappabianca
P
P
Vizioli
L
L
Maiuri
F
F
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002528:Cerebellar Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D003287:Contrast Media; D019786:Gadolinium DTPA; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D018325:Hemangioblastoma / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D009419:Nerve Tissue Proteins / Q000032:analysis; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D011956:Receptors, Cell Surface; D011975:Receptors, Mitogen / Q000032:analysis; D014841:von Willebrand Factor / Q000032:analysis
D014408:Biomarkers, Tumor; D003287:Contrast Media; D005904:Glial Fibrillary Acidic Protein; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D009942:Organometallic Compounds; D011956:Receptors, Cell Surface; D011975:Receptors, Mitogen; C053203:Ulex europaeus lectin receptor; D014841:von Willebrand Factor; D004369:Pentetic Acid; D010751:Phosphopyruvate Hydratase; D019786:Gadolinium DTPA