title: Rapid hepatic failure associated with a contracted liver mimicking cirrhosis in a case of nasopharyngeal carcinoma with liver metastasis.
abstract: A 46-year-old women had an undifferentiated nonkeratinizing nasopharyngeal carcinoma, locally controlled by radiotherapy. Initially, she had normal liver function tests and normal hepatic ultrasonography. Seven months later, she experienced a rapidly progressive hepatic failure manifested by the development of ascites, elevation of serum bilirubin level, and prolongation of prothrombin time. Imaging studies showed a contracted liver and serum biochemical tests were compatible with chronic liver disease, except for an increase of alkaline phosphatase and gamma-glutamyl transpeptidase levels. An endoscopic retrograde cholangiogram ws compatible with changes of sclerosing cholangitis. The patient died of hepatic decompensation within two months. A liver necropsy disclosed diffuse infiltration of carcinoma cells into the hepatic sinusoids and obliterative angio-invasion of the tumor cells with massive fibrotic stroma replacing almost all hepatocytes. In situ hybridization demonstrated expression of Epstein-Barr virus transcripts EBER1 in the tumor cells and proved a metastatic nasopharyngeal carcinoma. The contracted liver is likely to be explained by the tumor-associated desmoplastic change and the obliterative angio-invasion of the tumor. It is important to be aware that, although rare, such an unusual pattern of liver metastasis may mimick cirrhosis clinically and cause rapid hepatic failure in patients with nasopharyngeal carcinoma.
authors.affiliation: Department of Internal Medicine, College of Medicine, National Taiwan University Hospital, National Taiwan University, Tapei, Taiwan.
authors.forename: Y T
authors.initials: YT
authors.lastname: Hwang
authors.forename: P J
authors.initials: PJ
authors.lastname: Chen
authors.forename: J H
authors.initials: JH
authors.lastname: Kao
authors.forename: T D
authors.initials: TD
authors.lastname: Wang
authors.forename: H H
authors.initials: HH
authors.lastname: Wang
authors.forename: J S
authors.initials: JS
authors.lastname: Chu
authors.forename: I J
authors.initials: IJ
authors.lastname: Su
authors.forename: D S
authors.initials: DS
authors.lastname: Chen
mesh_terms: D015342:DNA Probes / Q000235:genetics; D005260:Female; D005355:Fibrosis / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans; D017403:In Situ Hybridization; D017093:Liver Failure / Q000378:metabolism*; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000378:metabolism*; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism; D009362:Neoplasm Metastasis; D011517:Prothrombin Time; D012367:RNA, Viral / Q000235:genetics; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D015342:DNA Probes; C099537:Epstein-Barr virus encoded RNA 1; D012367:RNA, Viral