A novel antioxidant alleviates heat hyperalgesia in rats with an experimental painful peripheral neuropathy.
Rats with an experimental painful peripheral neuropathy (the chronic injury (CCI) model) display heatevoked hyperalgesia. There is now considerable evidence that nitric oxide (NO) and nitric oxide synthase are involved in the development of hyperalgesia in acute inflammatory pain states. The mechanisms responsible for hyperalgesia in chronic pain state may involve not only NO itself, but also peroxynitrite, the product of its reaction with superoxide radical, .O2- that can lead to the formation of the free radicals .OH and NO2- Under normal metabolic conditions, the cellular enzyme super oxide dismutase (SOD) provides physiological defence against superoxide radicals. TEMPOL mimics SOD and acts as a catalyst to remove the .O2- radical. The present work shows the efficacy of a stable nitroxide radical, 4-hydroxy-2, 2, 6, 6-tetramethylpiperidine-1-oxyl (TEMPOL), against heat-evoked hyperalgesia.
Tal
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Department of Anatomy, Hebrew University-Hadassah Dental and Medical School, Jerusalem, Israel.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D005609:Free Radicals; D006358:Hot Temperature; D006930:Hyperalgesia / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D009437:Neuralgia / Q000188:drug therapy*; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D009589:Nitrogen Oxides / Q000627:therapeutic use*; D010523:Peripheral Nervous System Diseases / Q000150:complications*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D005609:Free Radicals; D018696:Neuroprotective Agents; D009589:Nitrogen Oxides; D013482:Superoxide Dismutase; C039900:nitroxyl