title: Pontine glioma with osteoblastic skeletal metastases in a child.
abstract: BACKGROUND
  The development of systemic metastases from primary intracranial gliomas is rare. We report here a rare case of pontine glioma with osteoblastic skeletal metastases.
  
  
  METHODS
  This 12-year-old boy presented with a 4-month history of hoarseness, dysphagia, and a progressively ataxic gait. Cranial computed tomography (CT) and magnetic resonance imaging (MRI) revealed a brain stem tumor that was diagnosed as a low grade glioma by stereotactic biopsy. Twelve months later following chemotherapy and radiotherapy, neurologic examination and neuroradiologic studies disclosed a recurrence of the pontine glioma. Skeletal roentgenograms revealed widespread osteoblastic metastases in the skull, vertebral bodies, pelvis, and long bones. A specimen from the iliac bone demonstrated cells that were immunoreactive glial fibrillary acidic protein (GFAP).
  
  
  CONCLUSIONS
  The mechanism of how glioma cells determine their biologic behavior at bony metastatic sites is not known. Infratentorial gliomas, which occur frequently in young patients and demonstrate active bony metabolism, may stimulate osteoblastic cells, and induce osteoblastic changes.
authors.affiliation: Department of Neurosurgery and Laboratory Medicine, National Defense Medical College, Saitama, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yanagawa
authors.forename: T
authors.initials: T
authors.lastname: Miyazawa
authors.forename: S
authors.initials: S
authors.lastname: Ishihara
authors.forename: H
authors.initials: H
authors.lastname: Takiguchi
authors.forename: K
authors.initials: K
authors.lastname: Shima
authors.forename: S
authors.initials: S
authors.lastname: Terahata
authors.forename: S
authors.initials: S
authors.lastname: Tamai
authors.forename: H
authors.initials: H
authors.lastname: Chigasaki
mesh_terms: D001859:Bone Neoplasms / Q000556:secondary*; D001932:Brain Neoplasms / Q000175:diagnosis*; D002648:Child; D005910:Glioma / Q000556:secondary*; D006801:Humans; D008297:Male; D010386:Pelvic Neoplasms / Q000556:secondary; D011149:Pons; D012888:Skull Neoplasms / Q000556:secondary; D013125:Spinal Neoplasms / Q000556:secondary