title: Selective gamma-chain T-cell receptor gene rearrangements in a patient with Omenn's syndrome: absence of V-II subgroup (V gamma 9) transcripts.
abstract: Only gamma-chain T-cell receptor transcripts utilizing V-1 subgroup gene segments were found in peripheral blood lymphocytes from a patient with Omenn's syndrome. gamma-Chain T-cell receptor transcripts utilizing the V gamma 9 (V-II subgroup) gene segment were absent in peripheral blood lymphocytes from this patient. V gamma 9 J gamma 1.2 C gamma 1 rearrangements are those primarily found in peripheral blood lymphocytes (70 to 85%) from normal donors.
authors.affiliation: Department of Immunology, M. D. Anderson Cancer Center, University of Texas, Houston, USA.
authors.forename: G
authors.initials: G
authors.lastname: Mathioudakis
authors.forename: R A
authors.initials: RA
authors.lastname: Good
authors.forename: Y
authors.initials: Y
authors.lastname: Chernajovsky
authors.forename: N K
authors.initials: NK
authors.lastname: Day
authors.forename: C D
authors.initials: CD
authors.lastname: Platsoucas
mesh_terms: D004802:Eosinophilia / Q000235:genetics; D015329:Gene Rearrangement, T-Lymphocyte / Q000235:genetics*; D054747:Histiocytic Sarcoma / Q000235:genetics; D006801:Humans; D007223:Infant; D008206:Lymphatic Diseases / Q000235:genetics; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics* / Q000302:isolation & purification; D016511:Severe Combined Immunodeficiency / Q000235:genetics* / Q000276:immunology*
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta