Cadmium induced alterations in somatosensory evoked potentials.
Pregnant Swiss albino rats were divided into three groups: control (C), cadmium (Cd) and non-cadmium (NCd) groups. Control animals received tap water; the Cd rats received Cd as CdCl2 in their drinking water during the experimental period, while the NCd group was given Cd during pregnancy, and given tap water after birth. Twenty-two days after birth, 15 rats (for each group) were taken from their mothers and continued to be treated with Cd (Cd group) or tap water (C and NCd groups) for an additional 38 days. After the treatment period, somatosensory evoked potentials (SEPs) of the three groups were recorded from central (Cz) referenced to frontal (Fz) following left posterior tibial nerve (PTN) stimulation. Amplitude spectra of SEPs were computed by fast Fourier transform (FFT) algorithm. There was a significant amplitude decrease in 1-3.5 Hz in the NCd group and 1-3.5 and 14-20 Hz frequency bands of the Cd group compared with the control group.
Agar
A
A
Department of Physiology, Faculty of Medicine, Akdeniz University, Arapsuyu, Antalya, Turkey.
Yargicoglu
P
P
Izgut
N
N
Senturk
U K
UK
Oguz
Y
Y
D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D002104:Cadmium / Q000097:blood / Q000494:pharmacology*; D004558:Electric Stimulation; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D005260:Female; D005583:Fourier Analysis; D015227:Lipid Peroxidation; D008297:Male; D011247:Pregnancy; D051381:Rats
D002104:Cadmium