title: Fluvoxamine increases the clozapine serum levels significantly.
abstract: In this case report we describe an interaction between clozapine and fluvoxamine in two physically healthy patients meeting the DSM-IIIR criteria for paranoid schizophrenia. The substantial rise of clozapine serum levels suggest that caution should be exercised when combining fluvoxamine with clozapine as the clozapine concentration may increase by a factor of 5-10.
authors.affiliation: Moisio Hospital, Mikkeli, Finland.
authors.forename: H J
authors.initials: HJ
authors.lastname: Koponen
authors.forename: E
authors.initials: E
authors.lastname: Leinonen
authors.forename: U
authors.initials: U
authors.lastname: Lepola
mesh_terms: D000328:Adult; D003024:Clozapine / Q000097:blood* / Q000627:therapeutic use; D004347:Drug Interactions; D016666:Fluvoxamine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D003024:Clozapine; D016666:Fluvoxamine