Near-infrared spectroscopic characterization of pharmaceutical powder blends.
Near-infrared (near-IR) spectroscopy was used to qualitatively assess the homogeneity of a typical direct compression pharmaceutical powder blend consisting of hydrochlorothiazide, fast-flo lactose, croscarmellose sodium, and magnesium stearate. Near-IR diffuse reflectance spectra were collected from thieved powder samples using a grating-based spectrometer. A second-derivative calculation and principal component analysis were performed on the spectra prior to qualitative evaluation. Blend homogeneity was determined using single- and multiple-sample bootstrap algorithms and traditional chi-square analysis. The results suggested that bootstrap techniques provided greater sensitivity for assessing blend homogeneity than chi-square calculations and that near-IR has great potential as an analytical tool in powder blend analysis.
Wargo
D J
DJ
Graduate School of Pharmaceutical Sciences, Division of Pharmaceutics, Duquesne University, Pittsburgh, PA 15282, USA.
Drennen
J K
JK
D002266:Carboxymethylcellulose Sodium; D006852:Hydrochlorothiazide; D007785:Lactose; D011208:Powders / Q000032:analysis* / Q000737:chemistry; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D013229:Stearic Acids; D013678:Technology, Pharmaceutical / Q000379:methods*; D013997:Time Factors
D011208:Powders; D013229:Stearic Acids; D006852:Hydrochlorothiazide; C031183:stearic acid; D007785:Lactose; D002266:Carboxymethylcellulose Sodium