Spontaneous bacterial peritonitis: an indication for liver transplantation?
BACKGROUND
Spontaneous bacterial peritonitis (SBP) is a serious complication in patients with cirrhosis and ascites with a poor prognosis. The survival pattern and the reasons for not performing a liver transplantation after an episode of SBP were analysed.


METHODS
A retrospective analysis during the period 1987-1992 in a tertiary referral and liver transplantation centre.


RESULTS
Sixty episodes of SBP were diagnosed in 52 patients with ascites. Thirty-two percent of the patients died within 30 days and 78% within 1 year. Forty patients who survived less than 1 year did not receive a liver transplantation for the following reasons: death within 30 days (n = 12), age above 65 years (n = 10), medical contraindications (n = 6), active alcohol abuse (n = 6), refusal of transplantation (n = 2), death while being analysed for, or awaiting transplantation (n = 4). Two patients had an auxiliary liver transplantation but died postoperatively.


CONCLUSIONS
SBP is a serious complication in patients with cirrhosis and ascites, with a high first-year mortality and a high recurrence rate. Although long-term survival after an episode of SBP is possible, liver transplantation should be considered for the patients with a progressive liver disease after a first episode of SBP.
Bac
D J
DJ
Dept. of Gastroenterology and Hepatology, University Hospital Rotterdam-Dijkzigt, The Netherlands.
D001201:Ascites / Q000150:complications; D001424:Bacterial Infections / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D002986:Clinical Trials as Topic; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications; D016031:Liver Transplantation; D010538:Peritonitis / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D011379:Prognosis; D012008:Recurrence; D012189:Retrospective Studies; D015996:Survival Rate