Sialic acid--marker of development and differentiation.
The authors discuss the role of structural diversity of various sialic acids in glycoconjugates, i. e. in glycoproteins and glycolipids of cell membranes and of body fluids under various physiologic and pathologic conditions, as summarized in recent reviews. Furthermore they report the conclusions of their own experiments regarding desialylation of intestinal brush-border enzymes during postnatal development in the rat and its induction after hydrocortisone injection. The mechanism of desialylation was investigated in the differentiating cells of Lieberkuhn crypts and at the levels of sialyltransferase transcription and of glucocorticoid receptors. These results are correlated with the findings of other authors and compared with the effect of dexamethasone in organ cultures of the fetal rat intestine.
Kraml
J
J
1st Institute of Medical Chemistry and Biochemistry, Charles University, Czech Republic.
Kadlecová
L
L
Kolínská
J
J
D000818:Animals; D015415:Biomarkers; D018819:Dipeptidyl Peptidase 4 / Q000737:chemistry; D006854:Hydrocortisone / Q000494:pharmacology; D007583:Jejunum / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism*; D051381:Rats; D012794:Sialic Acids / Q000737:chemistry / Q000378:metabolism*
D015415:Biomarkers; D012794:Sialic Acids; D018819:Dipeptidyl Peptidase 4; D006854:Hydrocortisone