title: The use of a synthetic prostaglandin E1 analog as a gastric protectant against aspirin-induced hemorrhage in the dog.
abstract: Misoprostol prevented gastric hemorrhage in dogs, each of which received aspirin (35 mg/kg body weight, orally q 8 hrs for 10 days). All dogs receiving aspirin alone had gastroscopic and histopathological lesions. No lesions were noted in four of five dogs given aspirin plus misoprostol (15 micrograms/kg body weight, q 8 hrs for five days; then 7.5 micrograms/kg body weight, q 8 hrs for five days). Four of 10 dogs receiving 15 micrograms/kg body weight of misoprostol developed diarrhea. The misoprostol dose was reduced to 7.5 micrograms/kg body weight, and the diarrhea subsided.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul 55108, USA.
authors.forename: T S
authors.initials: TS
authors.lastname: Bowersox
authors.forename: A J
authors.initials: AJ
authors.lastname: Lipowitz
authors.forename: R M
authors.initials: RM
authors.lastname: Hardy
authors.forename: G R
authors.initials: GR
authors.lastname: Johnston
authors.forename: D W
authors.initials: DW
authors.lastname: Hayden
authors.forename: S
authors.initials: S
authors.lastname: Schwartz
authors.forename: V L
authors.initials: VL
authors.lastname: King
mesh_terms: D000527:Alprostadil / Q000031:analogs & derivatives*; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D003967:Diarrhea / Q000139:chemically induced / Q000662:veterinary; D004283:Dog Diseases / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005243:Feces / Q000737:chemistry; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000517:prevention & control / Q000662:veterinary*; D006454:Hemoglobins / Q000032:analysis; D008297:Male; D016595:Misoprostol / Q000009:adverse effects / Q000627:therapeutic use; D011465:Prostaglandins, Synthetic / Q000627:therapeutic use*; D013270:Stomach / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D013272:Stomach Diseases / Q000139:chemically induced / Q000517:prevention & control / Q000662:veterinary*
chemical_list: D006454:Hemoglobins; D011465:Prostaglandins, Synthetic; D016595:Misoprostol; D000527:Alprostadil; D001241:Aspirin