title: Peripapillary fluorescein leakage in 11778 Leber's optic neuropathy.
abstract: A 17-year-old young man presented with a 2-month sequential visual loss in both eyes. Vision was 20/200 in the right eye and 20/400 in the left eye. Both discs were hyperemic with circumpapillary telangiectasia and nerve fiber swelling. Fluorescein angiography revealed a fuzzy hyperfluorescence due to leakage from dilated capillaries on both discs in the late transit. Molecular mitochondrial DNA study confirmed a homoplasmic 11778 Leber's optic neuropathy.
authors.affiliation: Department of Ophthalmology, Taipei Veterans General Hospital, Taiwan, Republic of China.
authors.forename: M Y
authors.initials: MY
authors.lastname: Yen
authors.forename: Y H
authors.initials: YH
authors.lastname: Wei
authors.forename: J H
authors.initials: JH
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D002199:Capillary Permeability; D004272:DNA, Mitochondrial / Q000235:genetics; D005260:Female; D019793:Fluorescein; D005451:Fluorescein Angiography; D005452:Fluoresceins / Q000378:metabolism*; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D015418:Optic Atrophies, Hereditary / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D009898:Optic Disk / Q000098:blood supply*; D009900:Optic Nerve / Q000473:pathology; D017354:Point Mutation; D012171:Retinal Vessels / Q000378:metabolism / Q000473:pathology; D013684:Telangiectasis / Q000473:pathology; D014792:Visual Acuity
chemical_list: D004272:DNA, Mitochondrial; D005452:Fluoresceins; D019793:Fluorescein