Inhibition of D-amino acid oxidase by alpha-keto acids analogs of amino acids.
The inhibition of D-amino acid oxidase by certain alpha-keto acids products of the reaction with D-amino acids, in particular alpha-keto acids that are analogs of the amino acids alanine, valine, leucine, phenylanaline, phenylglycine, tyrosine and tryptophan, is reported. All the alpha-keto acids assayed behaved as substrate competitive inhibitors of the enzyme. The relationship between the degree of inhibition and the structure of the inhibitor is discussed.
Moreno
J A
JA
Department of Chemical Engineering, University of Salamanca, Spain.
Montes
F J
FJ
Catalán
J
J
Galán
M A
MA
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001667:Binding, Competitive; D003605:D-Amino-Acid Oxidase / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005182:Flavin-Adenine Dinucleotide / Q000378:metabolism; D007651:Keto Acids / Q000494:pharmacology*; D007668:Kidney / Q000201:enzymology; D007700:Kinetics; D013379:Substrate Specificity; D013552:Swine / Q000378:metabolism
D000596:Amino Acids; D004791:Enzyme Inhibitors; D007651:Keto Acids; D005182:Flavin-Adenine Dinucleotide; D003605:D-Amino-Acid Oxidase