title: Intraoperative radiation therapy and chemotherapy for huge choroid plexus carcinoma in an infant--case report.
abstract: A 2-month-old boy presented with a huge choroid plexus carcinoma in the left cerebral hemisphere. Almost total resection of the tumor was achieved, but a remnant abruptly enlarged 5 months later, requiring reoperation. After radical resection of the tumor, intraoperative radiation (10 Gy) was delivered. Postoperative chemotherapy was performed with methotrexate and vincristine, selected on the basis of in vitro chemosensitivity testing. No recurrence of the tumor was detected 18 months after the second operation. Radical surgery with these adjuvant therapies may be a good method to control this aggressive disease in infants.
authors.affiliation: Department of Neurosurgery, Tohoku University School of Medicine, Sendai.
authors.forename: T
authors.initials: T
authors.lastname: Kumabe
authors.forename: T
authors.initials: T
authors.lastname: Tominaga
authors.forename: T
authors.initials: T
authors.lastname: Kondo
authors.forename: T
authors.initials: T
authors.lastname: Yoshimoto
authors.forename: T
authors.initials: T
authors.lastname: Kayama
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002277:Carcinoma / Q000175:diagnosis / Q000532:radiotherapy* / Q000601:surgery*; D016545:Choroid Plexus Neoplasms / Q000175:diagnosis / Q000532:radiotherapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D006801:Humans; D007223:Infant; D007430:Intraoperative Care; D008279:Magnetic Resonance Imaging; D008297:Male; D011182:Postoperative Care
chemical_list: D000970:Antineoplastic Agents