title: Monitoring set-up for selection of parameters for detection of hypoglycaemia in diabetic patients.
abstract: Recurrent severe hypoglycaemia is often an unsolved problem in diabetic patients under intensified insulin treatment. As no reliable long-term stable blood glucose sensor has yet been developed, registration of other body function changes could help to detect severe hypoglycaemia. A measuring system is described, capable on the one hand of recording EEG, heart rate, peripheral pulse, skin temperature, respiratory movements, skin impedance and arterial blood pressure, and capable of registering plasma glucose, counter-regulatory hormones, symptoms and cognitive performance under experimental conditions during hypoglycaemia, on the other. In a clinical study involving both insulin-induced hypoglycaemia in healthy subjects and insulin-dependent diabetic patients, the practical value and the character of changes of the recorded parameters are investigated. Currently insensitivity to hypoglycaemia, impracticability, complexity or susceptibility to artefacts make use of most parameters unsuitable for hypoglycaemia prevention. It is believed, however, that future efforts could result in indirect registration of hypoglycaemia, including a qualified combination of different parameters, individual adaptation in accordance with particular responses of individual patients, together with new measuring and sensor techniques.
authors.affiliation: Department of Biomedical Engineering and Physics, University of Vienna, Austria.
authors.forename: G
authors.initials: G
authors.lastname: Heger
authors.forename: K
authors.initials: K
authors.lastname: Howorka
authors.forename: H
authors.initials: H
authors.lastname: Thoma
authors.forename: G
authors.initials: G
authors.lastname: Tribl
authors.forename: J
authors.initials: J
authors.lastname: Zeitlhofer
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D017097:Electric Impedance; D004569:Electroencephalography; D005260:Female; D006339:Heart Rate; D006801:Humans; D007003:Hypoglycemia / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D010808:Physical Examination; D012879:Skin Physiological Phenomena; D012881:Skin Temperature
chemical_list: D001786:Blood Glucose