Synthesis and pharmacological profile of novel N-substituted N-[5H-[1]benzopyrano[4,3-d]pyrimidin-2-YL]-N-methylglycinamides.
The title compounds were synthesized by cyclizing 3-dimethylaminomethylene-4-chromanone with creatine to give the acid 2 that was successively converted into the corresponding amides 3a-f via diphenylphosphorylazide and the relevant amines. The free acid 2 and some of 3a-f showed antiinflammatory, hypotensive and antiarrhythmic properties.
Bruno
O
O
Instituto di Scienze Farmaceutiche dell'Universita, Genova, Italy.
Schenone
S
S
Ranise
A
A
Bondavalli
F
F
D'Amico
M
M
Filippelli
W
W
Berrino
L
L
Rossi
F
F
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D005998:Glycine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D051379:Mice; D051381:Rats
D000889:Anti-Arrhythmia Agents; D000893:Anti-Inflammatory Agents; D000959:Antihypertensive Agents; C018556:glycine amide; D005998:Glycine