title: Elevation of cerebral lactate detected by localized 1H-magnetic resonance spectroscopy in migraine during the interictal period.
abstract: We used localized 1H-magnetic resonance spectroscopy (MRS) to study the metabolic changes in the brains of patients with migraine during the interictal period. Measurement of metabolite levels in the occipital visual cortex in six normal subjects and six patients disclosed high lactate levels in the five patients who had experienced a migraine attack within the previous 2 months. One patient who had not experienced a migraine attack in the previous 4 years did not show a lactate peak. We speculate that anaerobic glycolysis occurs in the brains of patients with migraine during the interictal period, and a long attack-free period may normalize the subclinical metabolic disturbance.
authors.affiliation: Department of Neurology, Niigata University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Kuwabara
authors.forename: M
authors.initials: M
authors.lastname: Ohkubo
authors.forename: S
authors.initials: S
authors.lastname: Tsuji
authors.forename: T
authors.initials: T
authors.lastname: Yuasa
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007773:Lactates / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008881:Migraine Disorders / Q000378:metabolism* / Q000503:physiopathology; D009778:Occipital Lobe / Q000378:metabolism*
chemical_list: D007773:Lactates