title: Endoplasmic reticulum is missing in dendritic spines of Purkinje cells of the ataxic mutant rat.
abstract: Dilute-opisthotonus (dop) is a spontaneous ataxic mutation in the rat, regulated by an autosomal recessive gene. Immunohistochemical staining with anti-inositol 1,4,5-trisphosphate receptor antibody and electron microscopic examinations revealed that the endoplasmic reticulum in dendritic spines of Purkinje cell was missing in the ataxic rat. This could impair the intracellular signal transduction in the parallel fiber-Purkinje cell synapse, and be a cause of the severe ataxic movement.
authors.affiliation: School of Agricultural Sciences, Nagoya University, Nagoya, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Dekker-Ohno
authors.forename: S
authors.initials: S
authors.lastname: Hayasaka
authors.forename: Y
authors.initials: Y
authors.lastname: Takagishi
authors.forename: S
authors.initials: S
authors.lastname: Oda
authors.forename: N
authors.initials: N
authors.lastname: Wakasugi
authors.forename: K
authors.initials: K
authors.lastname: Mikoshiba
authors.forename: M
authors.initials: M
authors.lastname: Inouye
authors.forename: H
authors.initials: H
authors.lastname: Yamamura
mesh_terms: D000818:Animals; D001259:Ataxia / Q000473:pathology*; D003712:Dendrites / Q000648:ultrastructure*; D018871:Endoplasmic Reticulum, Smooth / Q000648:ultrastructure*; D008854:Microscopy, Electron; D011689:Purkinje Cells / Q000648:ultrastructure*; D051381:Rats; D011922:Rats, Mutant Strains