title: Evaluation with MIB1 antibody of proliferative activity in ovarian clear cell adenocarcinoma.
abstract: The purpose of this study was to determine whether proliferative activity is a prognostic factor in ovarian clear cell adenocarcinoma. The paraffin-embedded sections from eight cases of ovarian clear cell adenocarcinoma were immunostained with monoclonal antibody MIB1 using microwave oven heating for antigen retrieval. The difference in survival (Kaplan-Meier) between patients with high and low MIB1 expression was estimated with the generalized Wilcoxon test. MIB1 positivity ranged from 1.80 to 27.12% with a mean of 11.43%. A cutoff point of 10% dichotomized patients into two groups. The survival of high (> or = 10%) expressing tumors was worse than that of low (< 10%) expressing tumors (p < 0.05). MIB1 immunostaining may have useful prognostic value in ovarian clear cell adenocarcinoma.
authors.affiliation: Department of Obstetrics and Gynecology, Fukushima Medical College, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Morimura
authors.forename: K
authors.initials: K
authors.lastname: Hoshi
authors.forename: X L
authors.initials: XL
authors.lastname: Hang
authors.forename: Y
authors.initials: Y
authors.lastname: Takano
authors.forename: M
authors.initials: M
authors.lastname: Ohishi
authors.forename: T
authors.initials: T
authors.lastname: Honda
authors.forename: H
authors.initials: H
authors.lastname: Yamada
authors.forename: A
authors.initials: A
authors.lastname: Sato
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000473:pathology*; D000328:Adult; D000911:Antibodies, Monoclonal; D002455:Cell Division; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D008938:Mitosis; D010051:Ovarian Neoplasms / Q000473:pathology*; D011379:Prognosis; D015203:Reproducibility of Results
chemical_list: D000911:Antibodies, Monoclonal