In vitro properties of a chitosan-bonded bone-filling paste: studies on solubility of calcium phosphate compounds.
The present study investigated properties of various mixtures of organic acids (malic and malonic) and calcium phosphate compounds (beta-tricalcium phosphate, ashed bovine bone, and synthetic hydroxyapatite) with the objective of determining the optimum combination of organic acid and calcium phosphate compound for components of a chitosan-bonded bone-filling paste. beta-tricalcium phosphate was decomposed by malic acid and malonic acid, but these two acids did not decompose synthetic hydroxyapatite and ashed bovine bone. Assessment of ion release from a set paste containing either synthetic hydroxyapatite or ashed bovine bone indicated that only calcium ions were appreciably released after storing and stirring the set paste in physiologic saline for 7 days.
Ito
M
M
Department of Biomaterials, Matsumoto Dental College, Nagano, Japan.
Yamagishi
T
T
Yagasaki
H
H
Kafrawy
A H
AH
D000818:Animals; D001672:Biocompatible Materials; D001843:Bone Cements; D002130:Calcium Phosphates; D002417:Cattle; D002686:Chitin / Q000031:analogs & derivatives*; D048271:Chitosan
D001672:Biocompatible Materials; D001843:Bone Cements; D002130:Calcium Phosphates; D002686:Chitin; D048271:Chitosan