A systematic survey of the intergenic region between the murine oxytocin- and vasopressin-encoding genes.
The genomic region between the oxytocin (OT) and vasopressin (VP) genes in the two strains of mice was independently sequenced by our two groups. In this report, we present our collated sequence data and analyses. The mouse intergenic region (MUIGR) was aligned to that of the rat, which has been reported to contain 6.4-kb long interspersed nuclear element (LINE). The MUIGR sequences in the two mice strains did not contain any LINE sequences. This suggests that the approximately 3.5-kb sequence that is conserved between the rat and mouse intergenic regions is likely to be involved in the regulation of OT and VP expression. We also observed several conserved putative transcription factor recognition sequences. Analysis of the MUIGR revealed the lack of any significant ORFs, but the presence of several repetitive elements.
Ratty
A K
AK
Institute of Molecular and Cell Biology, National University of Singapore, Singapore. nmiv18@leonis.nus.sg
Jeong
S W
SW
Nagle
J W
JW
Chin
H
H
Gainer
H
H
Murphy
D
D
Venkatesh
B
B
D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D017124:Conserved Sequence; D051379:Mice; D008969:Molecular Sequence Data; D010121:Oxytocin / Q000235:genetics*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D014667:Vasopressins / Q000235:genetics*
D014667:Vasopressins; D010121:Oxytocin