title: Biochemical and radiologic improvement in Paget's disease of bone treated with alendronate: a randomized, placebo-controlled trial.
abstract: OBJECTIVE
  The potent bisphosphonates offer great promise in the management of Paget's disease of bone, but are currently available only as parenteral preparations in most countries. There is a need for a well-tolerated, oral therapy. Furthermore, none of the currently available therapies have been rigorously demonstrated to heal the lytic bone lesions characteristic of this condition. Alendronate is a potent new oral aminobisphosphonate that has shown promising effects on Paget's disease in preliminary studies.
  
  
  METHODS
  We report a double-blind, randomized comparison of oral alendronate 40 mg/day and placebo over 6 months in 55 patients with Paget's disease. Efficacy was determined from measurements of biochemical indices of bone turnover (serum alkaline phosphatase and urine N-telopeptide) and blinded radiologic assessment of lytic bone lesions.
  
  
  RESULTS
  N-telopeptide excretion declined by 86% and serum alkaline phosphatase by 73% in patients receiving alendronate, but remained stable in patients receiving placebo (P < 0.001 between groups for both indices). Responses were similar whether or not patients had previously received bisphosphonate treatment. Alendronate treatment normalized alkaline phosphatase in 48% of patients. Forty-eight percent of alendronate-treated patients showed radiologic improvement in osteolysis whereas in the placebo group only 4% improved (P = 0.02 for between-groups comparison). No patient in either group showed worsening of osteolysis. Bone histomorphometry indicated that alendronate tended to normalize turnover indices. There was no evidence of abnormal mineralization in bone biopsies taken from 12 alendronate-treated subjects. The treatment was well tolerated.
  
  
  CONCLUSIONS
  Oral alendronate appears to be a safe and effective therapy for Paget's disease and results in healing of lytic bone lesions.
authors.affiliation: Department of Medicine, University of Auckland, New Zealand.
authors.forename: I R
authors.initials: IR
authors.lastname: Reid
authors.forename: G C
authors.initials: GC
authors.lastname: Nicholson
authors.forename: R S
authors.initials: RS
authors.lastname: Weinstein
authors.forename: D J
authors.initials: DJ
authors.lastname: Hosking
authors.forename: T
authors.initials: T
authors.lastname: Cundy
authors.forename: M A
authors.initials: MA
authors.lastname: Kotowicz
authors.forename: W A
authors.initials: WA
authors.lastname: Murphy
authors.forename: S
authors.initials: S
authors.lastname: Yeap
authors.forename: S
authors.initials: S
authors.lastname: Dufresne
authors.forename: A
authors.initials: A
authors.lastname: Lombardi
authors.forename: T A
authors.initials: TA
authors.lastname: Musliner
authors.forename: D E
authors.initials: DE
authors.lastname: Thompson
authors.forename: A J
authors.initials: AJ
authors.lastname: Yates
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D019386:Alendronate / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000469:Alkaline Phosphatase / Q000097:blood; D001706:Biopsy; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D002118:Calcium / Q000097:blood; D003094:Collagen / Q000652:urine; D024042:Collagen Type I; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000378:metabolism; D010455:Peptides / Q000652:urine; D010710:Phosphates / Q000097:blood; D011859:Radiography
chemical_list: D024042:Collagen Type I; D010455:Peptides; D010710:Phosphates; C052929:collagen type I trimeric cross-linked peptide; D003094:Collagen; D000469:Alkaline Phosphatase; D002118:Calcium; D019386:Alendronate