title: Zoster myelitis: improvement with antiviral therapy in two cases.
abstract: This report describes two patients with acquired immunodeficiency syndrome (AIDS) and herpes zoster myelopathy. Patient one had a T-8 myelitis that preceded the onset of T-8-distribution zoster and was followed by cervical myelopathy. Antibody to varicella zoster virus (VZV) was present in the CSF. He never received steroids or other immunosuppressive drugs, and his condition improved dramatically after treatment with intravenous acyclovir. The second patient had a rapidly progressive myelitis with paralysis of both legs. Detection of VZV DNA and antibody to VZV in his CSF led to successful treatment with famciclovir despite discontinuation of dexamethasone and earlier treatment failure with acyclovir. These cases support the idea that VZV myelopathy in the immunosuppressed host is caused by virus invasion. CSF analysis for antiviral antibody and for VZV DNA by polymerase chain reaction are helpful in establishing the diagnosis. Aggressive antiviral therapy is advised.
authors.affiliation: Department of Neurology, Veterans Affairs Medical Center, Washington, DC 20422, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: de Silva
authors.forename: A S
authors.initials: AS
authors.lastname: Mark
authors.forename: D H
authors.initials: DH
authors.lastname: Gilden
authors.forename: R
authors.initials: R
authors.lastname: Mahalingam
authors.forename: M
authors.initials: M
authors.lastname: Balish
authors.forename: F
authors.initials: F
authors.lastname: Sandbrink
authors.forename: S
authors.initials: S
authors.lastname: Houff
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000212:Acyclovir / Q000627:therapeutic use*; D000328:Adult; D004279:DNA, Viral / Q000134:cerebrospinal fluid; D006562:Herpes Zoster / Q000188:drug therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009187:Myelitis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology
chemical_list: D004279:DNA, Viral; D000212:Acyclovir