Alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin.
Taatjes
D J
DJ
Department of Chemistry and Biochemistry University of Colorado, Boulder 80309-0215, USA.
Gaudiano
G
G
Resing
K
K
Koch
T H
TH
D000478:Alkylation; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004247:DNA / Q000378:metabolism*; D003630:Daunorubicin / Q000494:pharmacology*; D004229:Dithiothreitol / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology*; D005557:Formaldehyde / Q000494:pharmacology; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D013058:Mass Spectrometry; D016877:Oxidants / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet; D013439:Sulfhydryl Reagents / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D016877:Oxidants; D013439:Sulfhydryl Reagents; D005557:Formaldehyde; D004317:Doxorubicin; D004247:DNA; D006861:Hydrogen Peroxide; D004229:Dithiothreitol; D003630:Daunorubicin