Effects of chronic infusion of nerve growth factor (NGF) in rats with nucleus basalis magnocellularis lesion.
We attempted to evaluate the effects of bilateral injection of ibotenic acid (IA) into the nucleus basalis magnocellularis (nbm) of rats as well as the potential recovery mediated by the infusion of nerve growth factor (NGF). The lesion caused an impairment of learning and memory processes. Also, a severe depletion of choline acetyl transferase activity was detected in cortical areas. After the NGF administration, a significant reversion of these functional changes was observed. Thus, IA-lesioned rats might serve as a model for the evaluation of neurotrophic factors actions on basal forebrain damaged neurons.
Fernández
C I
CI
Basic Division, International Center of Neurological Restoration, Havana, Cuba.
González
O
O
Soto
J
J
Alvarez
L
L
Lores
T
T
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003342:Corpus Striatum / Q000201:enzymology; D007051:Ibotenic Acid / Q000008:administration & dosage / Q000633:toxicity; D007262:Infusions, Intravenous; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology*; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D008845:Microinjections; D009414:Nerve Growth Factors / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013377:Substantia Innominata / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D013997:Time Factors; D015430:Weight Gain / Q000187:drug effects
D009414:Nerve Growth Factors; D007051:Ibotenic Acid; D002795:Choline O-Acetyltransferase