[A multivariate analysis approach to antineoplastic and antiviral structure-activity relationships to a series of podophyllotoxins].
In this work, the authors have used technics of multivariate analysis to determine the structure-activity relationships of 46 podophyllotoxin derivatives and analogs studied for their antineoplastic and antiviral activities. The obtained results allow to envisage the possible synthesis of more specific molecules by making modifications in the structure of the model molecular archetype.
Doré
J C
JC
Laboratoire de Chimie appliquée aux corps organisés, CNRS URA 4O1, Muséum National d'Histoire Naturelle, Paris, France.
Viel
C
C
Pageot
N
N
Gordaliza
M
M
Castro
A
A
del Corral
J M
JM
Feliciano
A S
AS
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015999:Multivariate Analysis; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D011034:Podophyllotoxin