[Probability of vaccine therapy for pancreas cancer].
To explore the possibility of vaccine therapy for pancreatic cancer using ras oncogenic protein related antigen we studied whether cytotoxic T lymphocyte for tumor rejection can be induced by vaccination using the peptide relating mutated ras protein. Splenocytes from mice immunized by peptide (9-15 mer) relating mutated ras protein with normal splenocytes specifically increased in the culture with the peptide. The harvested splenic lymphocytes from the mice had peptide specific lysis against B 6 fibroblast incubated with the peptide. These results suggested that immunization using the peptide relating mutated ras peptide with autologous antigen presenting cell can be a vaccine therapy for pancreatic cancer.
Takahashi
M
M
Dept. of Surgery II, Yokohama City University School of Medicine, Japan.
Togou
S
S
Yamaoka
H
H
Ichikawa
H
H
Shimada
H
H
Cheever
M A
MA
D000818:Animals; D019496:Cancer Vaccines / Q000627:therapeutic use*; D006801:Humans; D016233:Immunotherapy, Active; D051379:Mice; D008810:Mice, Inbred C57BL; D010190:Pancreatic Neoplasms / Q000276:immunology / Q000628:therapy*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D018631:ras Proteins / Q000235:genetics
D019496:Cancer Vaccines; D018631:ras Proteins