title: Sphincter of Oddi dysfunction.
abstract: Evidence continues to accumulate indicating that sphincter of Oddi dysfunction may give rise to cholestasis, pancreatitis, or upper abdominal pain syndromes. Diagnosis of such dysfunction may be inferred from noninvasive tests or more precisely defined by manometric studies. Both the biliary and pancreatic sphincters are commonly involved. If medical therapy is ineffective, sphincter ablation via endoscopy or laparotomy should be considered for highly symptomatic patients. Complication rates of invasive techniques remain relatively high and risk:benefit ratio should be carefully considered. Future research as to etiology, more defined pathophysiology, more accurate noninvasive evaluation, and optimal therapies are awaited.
authors.affiliation: Department of Medicine, Indiana University Medical Center, Indianapolis 46202-5000, USA. glenl@medicine.dmed.iupui.edu
authors.forename: G A
authors.initials: GA
authors.lastname: Lehman
authors.forename: S
authors.initials: S
authors.lastname: Sherman
mesh_terms: D003137:Common Bile Duct Diseases / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D005544:Forecasting; D006801:Humans; D008365:Manometry / Q000379:methods; D010182:Pancreatic Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D009803:Sphincter of Oddi