SRS-A antagonist pyranoquinolone alkaloids from east African Fagara plants and their synthesis.
Three pyranoquinolone alkaloids isolated from two East African Fagara plants have been found to exhibit SRS-A antagonist action. Their synthesis has been accomplished, using a modified Coppola's method or a thermal cyclization followed by an electrocyclic ring closure.
Kamikawa
T
T
Department of Chemistry, Faculty of Science and Technology, Kinki University, Osaka.
Hanaoka
Y
Y
Fujie
S
S
Saito
K
K
Yamagiwa
Y
Y
Fukuhara
K
K
Kubo
I
I
D042462:4-Quinolones; D000351:Africa, Eastern; D000470:Alkaloids / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry*; D002855:Chromatography, Thin Layer; D010936:Plant Extracts / Q000737:chemistry*; D013189:SRS-A / Q000037:antagonists & inhibitors*; D013055:Spectrophotometry, Infrared; D014197:Trees / Q000737:chemistry*
D042462:4-Quinolones; D000470:Alkaloids; D000890:Anti-Infective Agents; D010936:Plant Extracts; D013189:SRS-A