The effects of atrial natriuretic peptide (ANP1-28) on corticotropin releasing factor in brain of rats.
We have shown that ANP has anxiolytic-like effects in behavioral studies. Since CRF is thought to be involved in emotional state of the brain, the present study was undertaken to follow the possible alterations in corticotropin-releasing factor-like immunoreactivity (CRF-LI) in different regions of the brain in rats following ANP treatment. CRF-LI immunoreactivity was determined in hypothalamic and extrahypothalamic brain areas after central injection of atrial natriuretic peptide 1-28 (ANP1-28) in rats. After various doses of ANP1-28 administration the CRF-LI significantly increased in the hypothalamus, the hippocampus and the frontal cortex. In the amygdala, ANP caused a marked but nonsignificant CRF-LI enhancement. In the basal forebrain, the CRF-LI decreased. These results suggest that ANP1-28 may moderate activation of the CRF-ergic system in the brain which could be related to the neuroendocrine and behavioral action.
Biró
E
E
Department of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Gardi
J
J
Vecsernyés
M
M
Julesz
J
J
Tóth
G
G
Telegdy
G
G
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D009320:Atrial Natriuretic Factor; D003346:Corticotropin-Releasing Hormone