title: Tissue plasminogen activator, tissue plasminogen activator inhibitor and lipoprotein(a) in patients with coronary, epiaortic and peripheral occlusive artery disease.
abstract: In order to evaluate the relationship between the presence of atherosclerotic disease, documented by angiography, and the fibrinolytic profile, 262 consecutive patients affected by coronary (n = 90), epiaortic (n = 60) and peripheral (n = 104) artery disease have been included in the study. Twenty-two healthy subjects were used as controls for laboratory parameters determination. All patients were classified on the basis of the presence (S+) or absence (S-) of clinically significant stenosis, according to specific scoring systems. Lipoprotein(a), plasminogen activator inhibitor (PAI-1), tissue plasminogen activator (t-PA) and the PAI-1/t-PA ratio were significantly lower in controls than in coronary, epiaortic and peripheral artery disease patients. However, the levels of these parameters were not statistically different between S+ and S- subjects. These results confirm the association between lipoprotein(a), PAI-1 and t-PA levels and the presence of atherosclerotic disease independently of the arterial districts considered, while they do not appear to be directly linked to the severity of the morphological disease.
authors.affiliation: Institute of Radiology, Chieti University School of Medicine, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Caputo
authors.forename: G
authors.initials: G
authors.lastname: Mantini
authors.forename: I
authors.initials: I
authors.lastname: Floriani
authors.forename: M
authors.initials: M
authors.lastname: Ciceri
authors.forename: A
authors.initials: A
authors.lastname: Noseda
authors.forename: L
authors.initials: L
authors.lastname: Bonomo
mesh_terms: D000328:Adult; D000368:Aged; D001018:Aortic Diseases / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D003327:Coronary Disease / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007118:Immunoassay; D008074:Lipoproteins / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood / Q000378:metabolism*; D012016:Reference Values; D012680:Sensitivity and Specificity; D010959:Tissue Plasminogen Activator / Q000097:blood / Q000378:metabolism*
chemical_list: D008074:Lipoproteins; D017395:Plasminogen Activator Inhibitor 1; D010959:Tissue Plasminogen Activator