Kinetics of anti-mannan antibodies useful in confirming invasive candidiasis in immunocompromised patients.
In studying the anti-mannan antibodies longitudinally in serial serum samples of three immunocompromised patients, it was observed that anti-mannan antibodies started to increase shortly after the moment that cultures of deep-tissue sites became positive with Candida albicans. The mean anti-mannan antibody titers determined in a group of 36 immunocompromised patients with invasive candidiasis increased within two weeks after the probable onset of invasive candidiasis. In contrast, anti-mannan antibody levels in serial serum samples of 14 immunocompromised patients who were only colonized with C. albicans remained stable or decreased over time. The HA test measuring the anti-mannan antibodies was 64% sensitive and 89% specific in determining invasive candidiasis. In contrast, antibodies specific for candidal cytoplasmic antigens or enolase alone were of little value in confirming invasive candidiasis in these immunocompromised patients.
van Deventer
A J
AJ
Department of Clinical Microbiology and Antimicrobial Therapy, Erasmus University School of Medicine, Rotterdam, Netherlands.
Goessens
W H
WH
van Zeijl
J H
JH
Mouton
J W
JW
Michel
M F
MF
Verbrugh
H A
HA
D000293:Adolescent; D000328:Adult; D000908:Antibodies, Fungal / Q000097:blood / Q000276:immunology*; D000946:Antigens, Fungal / Q000097:blood / Q000276:immunology*; D002176:Candida albicans / Q000276:immunology* / Q000302:isolation & purification; D002177:Candidiasis / Q000097:blood / Q000188:drug therapy / Q000276:immunology* / Q000382:microbiology; D003378:Counterimmunoelectrophoresis; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016867:Immunocompromised Host / Q000276:immunology*; D007700:Kinetics; D008297:Male; D008351:Mannans / Q000032:analysis / Q000276:immunology*; D011933:Reagent Kits, Diagnostic
D000908:Antibodies, Fungal; D000946:Antigens, Fungal; D008351:Mannans; D011933:Reagent Kits, Diagnostic