Influences of body weight, body composition, and substrate oxidation rate on resting postabsorptive glucose production and gluconeogenesis.
OBJECTIVE
To determine the influence of body weight, fat mass, and fat distribution on resting endogenous glucose production in healthy lean and overweight individuals.


METHODS
measurements were performed in the resting postabsorptive state in individuals receiving an unrestricted diet.


METHODS
Institute of Physiology of Lausanne University.


METHODS
resting post absorptive glucose production, glycogenolysis and gluconeogenesis; resting energy expenditure and net substrate oxidation.


RESULTS
Endogenous glucose production was positively correlated with body weight, lean body mass, energy expenditure and carbohydrate oxidation. Gluconeogenesis was positively correlated with net lipid oxidation and energy expenditure, and negatively correlated with net carbohydrate oxidation. No correlation with body fat or fat distribution was observed.


CONCLUSIONS
Gluconeogenesis shows a large interindividual variability. Net lipid oxidation and not body fat appears to be a major determinant of gluconeogenesis.
Giusti
V
V
Department of Internal Medicine, Lausanne University Hospital, Switzerland.
Schneiter
P
P
Thiébaud
D
D
Landry
M
M
Burckhardt
P
P
Jéquier
E
E
Tappy
L
L
D000328:Adult; D001823:Body Composition; D015992:Body Mass Index; D001835:Body Weight; D050260:Carbohydrate Metabolism; D004734:Energy Metabolism; D005260:Female; D005943:Gluconeogenesis / Q000502:physiology*; D005947:Glucose / Q000096:biosynthesis*; D006003:Glycogen / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D050356:Lipid Metabolism; D008297:Male; D010084:Oxidation-Reduction
D006003:Glycogen; D005947:Glucose