Metabolic and endocrine effects of interleukin-1 in obese, diabetic Zucker fa/fa rats.
IL-1, a cytokine produced predominantly by cell from the macrophage lineage, can affect multiple neuroendocrine and metabolic functions. We report here effects of this cytokine in obese, diabetic Zucker fa/fa rats. These animals are modestly hyperglycemic, hyper-lipemic, and markedly hyperinsulinemic. Changes in the levels of glucose, lactate, triglycerides, free fatty acids, insulin, glucagon, and corticosterone were detected following a single intraperitoneal or intravenous injection of IL-1 into fa/fa rats. No comparable changes were observed following administration of insulin. In fa/fa rats, the diabetic status is particularly manifested by an abnormal glucose tolerance. Administration of a bolus injection of IL-1 normalized the response of diabetic fa/fa rats to a glucose load. These rats not only returned to their basal glucose levels quicker, but reached glucose concentrations in blood which were comparable to, or even lower than those of Fa/? rats. Although the mechanism underlying the effects of IL-1 in fa/fa rats are presently not clear, the results obtained suggest that this cytokine tends to normalize glucose homeostasis and stimulate fat mobilization in these animals.
del Rey
A
A
Institute of Physiology, Philipps University, Marburg, Germany.
Monge-Arditi
G
G
Klusman
I
I
Besedovsky
H O
HO
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D003345:Corticosterone / Q000097:blood / Q000378:metabolism; D003920:Diabetes Mellitus / Q000097:blood* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000378:metabolism; D004195:Disease Models, Animal; D005230:Fatty Acids, Nonesterified / Q000097:blood / Q000378:metabolism; D005934:Glucagon / Q000097:blood / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007274:Injections, Intraperitoneal; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D007375:Interleukin-1 / Q000008:administration & dosage / Q000494:pharmacology*; D019344:Lactic Acid / Q000097:blood / Q000378:metabolism; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity; D051381:Rats; D011924:Rats, Zucker; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D007375:Interleukin-1; D008055:Lipids; D011994:Recombinant Proteins; D014280:Triglycerides; D019344:Lactic Acid; D005934:Glucagon; D002784:Cholesterol; D003345:Corticosterone