title: Pathogenicity, attenuation, and immunogenicity of infectious bursal disease virus.
abstract: An investigation was conducted in specific-pathogen-free chickens on the pathogenicity of bursa-derived and tissue culture-attenuated classic (STC) and variant (IN) serotype 1 strains of infectious bursal disease virus. The IN bursa-derived virus caused bursal inflammation, necrosis, and atrophy earlier than the bursa-derived STC virus. Both viruses lost their pathogenicity after four passages in BGM-70 cells. A statistically significant level (P < 0.05) of protection was observed in SPF chickens vaccinated with the attenuated IN virus used as a live or inactivated vaccine followed by homologous (IN) and heterologous (STC) challenge with bursa-derived viruses.
authors.affiliation: Food Animal Health Research Program, Ohio Agricultural Research and Development Center, Ohio State University, Wooster 44691, USA.
authors.forename: M K
authors.initials: MK
authors.lastname: Hassan
authors.forename: M Q
authors.initials: MQ
authors.lastname: Al-Natour
authors.forename: L A
authors.initials: LA
authors.lastname: Ward
authors.forename: Y M
authors.initials: YM
authors.lastname: Saif
mesh_terms: D000818:Animals; D018175:Birnaviridae Infections / Q000276:immunology / Q000662:veterinary; D002060:Bursa of Fabricius / Q000821:virology; D002645:Chickens / Q000276:immunology / Q000821:virology; D007243:Infectious bursal disease virus / Q000276:immunology* / Q000472:pathogenicity; D009500:Neutralization Tests / Q000662:veterinary; D011201:Poultry Diseases / Q000276:immunology / Q000821:virology; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology
chemical_list: D014613:Vaccines, Attenuated; D014765:Viral Vaccines