Lessons for neurotoxicology from selected model compounds: SGOMSEC joint report.
The ability to identify potential neurotoxicants depends upon the characteristics of our test instruments. The neurotoxic properties of lead, methylmercury, polychlorinated biphenyls, and organic solvents would all have been detected at some dose level by tests in current use, provided that the doses were high enough and administered at an appropriate time such as during gestation. The adequacy of animal studies, particularly rodent studies, to predict intake levels at which human health can be protected is disappointing, however. It is unlikely that the use of advanced behavioral methodology would alleviate the apparent lack of sensitivity of the rodent model for many agents.
Rice
D C
DC
Banting Research Centre, Ottawa, Ontario, Canada. drice@bcad1.food.hwc.ca
Evangelista de Duffard
A M
AM
Duffard
R
R
Iregren
A
A
Satoh
H
H
Watanabe
C
C
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004782:Environmental Health; D006801:Humans; D007855:Lead Poisoning / Q000523:psychology; D008767:Methylmercury Compounds / Q000009:adverse effects / Q000633:toxicity; D009498:Neurotoxins / Q000009:adverse effects / Q000633:toxicity*; D011078:Polychlorinated Biphenyls / Q000009:adverse effects / Q000633:toxicity; D018675:Toxicity Tests / Q000379:methods
D008767:Methylmercury Compounds; D009498:Neurotoxins; D011078:Polychlorinated Biphenyls