title: Lenńox-Gastaut syndrome associated with leukoencephalopathy.
abstract: We report a 13-year-old boy with Lennox-Gastaut syndrome (LGS) associated with leukoencephalopathy. He was diagnosed with unclassified acute lymphocytic leukemia at the age of 3 years. After initial chemotherapy, he received intravenous methotrexate (total dosage 1,035 mg), intrathecal methotrexate (total dosage 221 mg), and whole brain irradiation (2,400 cGy). From about the age of 8 years, he developed slurred speech, hyperactivity, and mental deterioration. Cranial CT revealed calcification of the subcortical white matter. At age 9 years, he exhibited tonic seizures and atonic seizures. EEG showed diffuse slow spike-wave discharges, which are characteristic of LGS. Although multiple antiepileptic drugs have been prescribed, the frequency of seizures remains unchanged and his mental state is becoming progressively worse.
authors.affiliation: Department of Pediatrics, Kyoto First Red Cross Hospital, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Mitsufuji
authors.forename: H
authors.initials: H
authors.lastname: Ikuta
authors.forename: H
authors.initials: H
authors.lastname: Yoshioka
authors.forename: T
authors.initials: T
authors.lastname: Sawada
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001925:Brain Damage, Chronic / Q000209:etiology*; D002114:Calcinosis / Q000209:etiology*; D016371:Cranial Irradiation / Q000009:adverse effects*; D003561:Cytarabine / Q000008:administration & dosage; D003704:Dementia / Q000209:etiology*; D004317:Doxorubicin / Q000008:administration & dosage; D004569:Electroencephalography; D004832:Epilepsy, Absence / Q000188:drug therapy / Q000209:etiology; D004829:Epilepsy, Generalized / Q000209:etiology*; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D015122:Mercaptopurine / Q000008:administration & dosage; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D009069:Movement Disorders / Q000209:etiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000532:radiotherapy; D011239:Prednisolone / Q000008:administration & dosage; D011832:Radiation Injuries / Q000209:etiology*; D013577:Syndrome; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000927:Anticonvulsants; D003561:Cytarabine; D014750:Vincristine; D004317:Doxorubicin; D011239:Prednisolone; D015122:Mercaptopurine; D008727:Methotrexate