Biochemical and biomolecular aspects of oxidative stress due to acute and severe hypoxia in human muscle tissue.
Mitochondrial oxidative stress was investigated in severe and acute hypoxia and in reperfusion applied to human muscle tissues. The biochemical and biomolecular relationship between the response of the respiratory-chain enzymic complexes and the metabolism of specific hypoxia stress proteins (HSP) suggest an adaptive mechanism which antagonizes the oxidative damage due to acute and severe tissue hypoxia.
Corbucci
G G
GG
Institute of Anaesthesia and Resuscitation, University of Cagliari, Italy.
Sessego
R
R
Velluti
C
C
Salvi
M
M
D000208:Acute Disease; D000222:Adaptation, Physiological; D003593:Cytoplasm / Q000201:enzymology; D003576:Electron Transport Complex IV / Q000378:metabolism; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D000860:Hypoxia / Q000378:metabolism*; D008931:Mitochondria, Muscle / Q000201:enzymology; D009132:Muscles / Q000378:metabolism*; D018384:Oxidative Stress; D013385:Succinate Dehydrogenase / Q000378:metabolism
D018840:HSP70 Heat-Shock Proteins; D013385:Succinate Dehydrogenase; D003576:Electron Transport Complex IV