title: Interferon-gamma in autoimmunity.
abstract: Autoimmune disorders are characterized by abrogation of self-tolerance, resulting in emergence of activated self-reactive lymphocyte clones that trigger or maintain inflammatory reactions in specific organs. Interferon-gamma (IFN-gamma), as well as other cytokines, plays an important role as a regulator of the activation of self-reactive lymphocytes and of bystander and accessory cells that are involved in the autoimmune inflammatory response. In experimental models of autoimmunity, endogenous IFN-gamma has invariably been found to profoundly affect the disease course. However, it acts in one way in some diseases and in the opposite way in others.
authors.affiliation: Laboratory of Immunobiology, Rega Institute, University of Leuven, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Billiau
mesh_terms: D000818:Animals; D000917:Antibody Formation; D015551:Autoimmunity; D004195:Disease Models, Animal; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology; D007371:Interferon-gamma / Q000276:immunology*; D009928:Organ Specificity / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology
chemical_list: D007369:Interferon Inducers; D007371:Interferon-gamma