title: Shrinkage and recovery of cells of the lateral geniculate nuclei with prism-rearing in macaques.
abstract: Infant macaque monkeys (Macaca mulatta) were subjected to optical dissociation of binocular vision by wearing prisms before their eyes for 30 days, beginning about 30 days of age. Such treatment mimicked strabismus during infancy and resulted in a dramatic loss of cortical binocular neurons. A concurrent shrinkage of 21% was found in the cells of the lateral geniculate nuclei (LGN) at the end of a terminal electrophysiological study at 60 days of age. A group of monkeys surviving for 5 years showed recovery of normal cell size, even though they did not recover functional binocular neurons in visual cortex.
authors.affiliation: Department of Ophthalmology and Visual Science, University of Texas Medical School at Houston, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Crawford
authors.forename: G K
authors.initials: GK
authors.lastname: von Noorden
mesh_terms: D000818:Animals; D048429:Cell Size / Q000502:physiology; D004594:Electrophysiology; D005260:Female; D005829:Geniculate Bodies / Q000166:cytology* / Q000502:physiology*; D008253:Macaca mulatta; D008297:Male; D009474:Neurons / Q000502:physiology* / Q000648:ultrastructure; D015348:Vision, Binocular / Q000502:physiology*; D014793:Visual Cortex / Q000502:physiology