Decrease in exploratory behavior in naturally occurring cholecystokinin (CCK)-A receptor gene knockout rats.
We recently found a specific strain of rats (Otsuka Long Evans Tokushima Fatty; OLETF rats) lacking cholecystokinin (CCK)-A receptor because of a genetic abnormality. Since CCK is an abundant neurotransmitter peptide in the brain, we examined whether these animals exhibit any behavioral abnormalities by conducting open-field tests. OLETF rats showed hypolocomotor activity and a decrease in the incidence of rearing in open-field tests. CCK release from the synaptosomes, and levels of CCK and CCK-B receptor mRNAs were the same as those observed in normal rats. It is suggested that the decreased exploration in OLETF rats may be due to the lack of CCK-A receptor.
Kobayashi
S
S
Department of Experimental Biology, Tokyo Metropolitan Institute of Gerontology, Japan.
Ohta
M
M
Miyasaka
K
K
Funakoshi
A
A
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D005106:Exploratory Behavior / Q000502:physiology*; D006120:Grooming / Q000502:physiology; D006727:Hormone Antagonists / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009154:Mutation; D011377:Proglumide / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains; D043886:Receptor, Cholecystokinin A; D011949:Receptors, Cholecystokinin / Q000235:genetics*; D012016:Reference Values
D006727:Hormone Antagonists; D043886:Receptor, Cholecystokinin A; D011949:Receptors, Cholecystokinin; C053737:loxiglumide; D011377:Proglumide