title: m-Chlorophenylpiperazine challenge in borderline personality disorder: relationship of neuroendocrine response, behavioral response, and clinical measures.
abstract: We have previously found that a subgroup of patients with impulsive personality disorders respond to m-chlorophenylpiperazine (m-CPP) administration with a distinctive spacy/high behavioral reaction and with increased cortisol responses. In this report we analyzed the relationship between behavioral and neuroendocrine responses to m-CPP in an enlarged sample of patients with borderline personality disorder (BPD). We also assessed the association of behavioral and neuroendocrine responses with clinical symptoms and with m-CPP blood levels. We found that in BPD patients the presence of a spacy/high behavioral response was significantly associated with increased prolactin and cortisol responses to m-CPP. In BPD patients increased m-CPP levels were significantly associated with neuroendocrine hypersensitivity and with a spacy/high behavioral response, while in controls increased m-CPP levels were not significantly associated with neuroendocrine hypersensitivity but were significantly associated with dysphoric behavioral responses. Taken together with previous work on m-CPP in obsessive-compulsive disorder, these results are partially consistent with the hypothesis that compulsive and impulsive symptoms fall at opposite ends of a phenomenologic and neurobiologic spectrum.
authors.affiliation: Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa.
authors.forename: D J
authors.initials: DJ
authors.lastname: Stein
authors.forename: E
authors.initials: E
authors.lastname: Hollander
authors.forename: C M
authors.initials: CM
authors.lastname: DeCaria
authors.forename: D
authors.initials: D
authors.lastname: Simeon
authors.forename: L
authors.initials: L
authors.lastname: Cohen
authors.forename: B
authors.initials: B
authors.lastname: Aronowitz
mesh_terms: D000328:Adult; D001519:Behavior / Q000187:drug effects*; D001883:Borderline Personality Disorder / Q000523:psychology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D009490:Neurosecretory Systems / Q000187:drug effects / Q000502:physiology*; D010879:Piperazines / Q000097:blood; D011388:Prolactin / Q000097:blood; D011569:Psychiatric Status Rating Scales; D017366:Serotonin Receptor Agonists / Q000097:blood
chemical_list: D010879:Piperazines; D017366:Serotonin Receptor Agonists; D011388:Prolactin; C015068:1-(3-chlorophenyl)piperazine; D006854:Hydrocortisone