title: Evaluation of liver function tests to predict operative risk in liver surgery.
abstract: Despite numerous studies in the past it is not possible yet to predict postoperative liver failure and safe limits for hepatectomy. In this study the following liver function tests ICG-ER (indocyaninegreen elimination rate), GEC (galactose elimination capacity) and MEGX-F (monoethylglycinexylidid formation) are examined with regard to loss of liver tissue and prediction of operative risk. Liver function tests were assessed in 20 patients prior to liver resection and on the 10th. postoperative day. Liver and tumor volume were measured by ultrasound and pathologic specimen and the parenchymal resection rate was calculated. In patients without cirrhosis (n = 10) ICG-ER and MEGX-F remained unchanged after resection, GEC was reduced but did not correspond to the resection rate. Patients with cirrhosis (n = 10) had a significantly lower ICG-ER and GEC before resection than patients without cirrhosis. After resection these tests were unchanged. Patients with liver related complications and cirrhosis (n = 5) had lower ICG-ER and GEC than patients with cirrhosis and no complications. In the postoperative course all liver function tests in these patients were significantly lower compared to preoperative results. Comparing liver function tests ICG serves best to indicate postoperative liver failure. Liver function tests do not correspond with loss of liver tissue.
authors.affiliation: Department of General Surgery, Heinrich Heine University, Dusseldorf, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Zoedler
authors.forename: C
authors.initials: C
authors.lastname: Ebener
authors.forename: H
authors.initials: H
authors.lastname: Becker
authors.forename: H D
authors.initials: HD
authors.lastname: Roeher
mesh_terms: D005690:Galactose / Q000378:metabolism; D006801:Humans; D007208:Indocyanine Green / Q000378:metabolism; D008012:Lidocaine / Q000031:analogs & derivatives / Q000378:metabolism; D008107:Liver Diseases / Q000503:physiopathology / Q000601:surgery*; D017093:Liver Failure / Q000453:epidemiology*; D008111:Liver Function Tests; D011183:Postoperative Complications / Q000453:epidemiology*; D011237:Predictive Value of Tests; D012307:Risk Factors
chemical_list: D008012:Lidocaine; C001173:monoethylglycinexylidide; D007208:Indocyanine Green; D005690:Galactose