Low-dose imipramine for thioridazine-induced male orgasmic disorder.
Male orgasmic disorder is commonly encountered among patients treated with thioridazine. This side effect interferes significantly with sexual satisfaction. In this pilot study, eight male schizophrenic patients who complained of orgasmic disorder, compatible with probable retrograde ejaculation during thioridazine treatment, were given concomitant low-dose imipramine (25-50 mg at bedtime). Four of the eight reported complete resumption of their previous ejaculatory function, and in one patient there was a partial, but substantial, improvement. Three patients noted no change. It appears that imipramine might be beneficial for some patients with thioridazine-induced male orgasmic disorder.
Aizenberg
D
D
Geha Psychiatric Hospital, Rabin Medical Center, Petah Tiqva, Israel.
Shiloh
R
R
Zemishlany
Z
Z
Weizman
A
A
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004542:Ejaculation / Q000187:drug effects; D006801:Humans; D007099:Imipramine / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D009948:Orgasm / Q000187:drug effects*; D012559:Schizophrenia / Q000188:drug therapy; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced*; D013881:Thioridazine / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use
D014150:Antipsychotic Agents; D013881:Thioridazine; D007099:Imipramine