Intraseptal injections of NGF attenuates edema formation following septal lesions in the rat.
Rats with electrolytic lesions of the medial septum received a single intraseptal injection of either nerve growth factor (NGF) or saline immediately following surgery. The formation of edema was then assessed at five time points following the lesions to the septum: 6 h, 1 day, 2 days, 3 days, and 5 days. Edema formation was detected as early as 6 h in both groups. However, by 2 days following surgery, the NGF treated rats had significantly less edema formation than their lesion alone counterparts. These results can be taken to indicate that NGF may alter locally mediating events that limit the effects of reactions associated with the inflammation of damaged tissue.
Janis
L S
LS
Institute of Animal Behavior, Rutgers-The State University of New Jersey, Newark 07102, USA.
Stein
D G
DG
D000818:Animals; D001927:Brain Diseases / Q000150:complications; D001929:Brain Edema / Q000517:prevention & control*; D007267:Injections; D008297:Male; D009414:Nerve Growth Factors / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012688:Septum Pellucidum / Q000473:pathology / Q000503:physiopathology*; D013997:Time Factors
D009414:Nerve Growth Factors