title: Proteasomes: destruction as a programme.
abstract: Proteasomes are large multi-subunit protease complexes that selectively degrade intracellular proteins. Most of the proteins removed by these proteases are tagged for destruction by ubiquitination. Proteasomes have a role to play in controlling cellular processes, such as metabolism and the cell cycle, through signal-mediated proteolysis of key enzymes and regulatory proteins. They also operate in the stress response, by removing abnormal proteins, and in the immune response, by generating antigenic peptides.
authors.affiliation: Institut für Biochemie, Universität Stuttgart, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Hilt
authors.forename: D H
authors.initials: DH
authors.lastname: Wolf
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D002453:Cell Cycle; D003546:Cysteine Endopeptidases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007109:Immunity; D008958:Models, Molecular; D009097:Multienzyme Complexes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D046988:Proteasome Endopeptidase Complex; D011506:Proteins / Q000378:metabolism*; D013312:Stress, Physiological; D014452:Ubiquitins / Q000378:metabolism
chemical_list: D009097:Multienzyme Complexes; D011506:Proteins; D014452:Ubiquitins; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex