title: The influence of acoustic impedance mismatch on post-stenotic pulsed-Doppler ultrasound measurements in a coronary artery model.
abstract: Acoustic impedance mismatch at the fluid-wall interface was shown to affect the spectra from an intravascular Doppler device in an in vitro model with a diameter typical of human coronary arteries. Measurements were obtained first under Poiseuille flow conditions with impedance mismatches of 0%, 7% and 12%, and then under stenosed conditions for the 0% and 7% mismatch cases. For the zero mismatch case, the Doppler spectra could be readily interpreted in terms of fluid mechanical phenomena. When mismatch was present, the spectra from Poiseuille flow exhibited multiple peaks which could not be directly related to the velocity profile. Also, the spectra from stenosed flow with a mismatch of 7% were similar to those from the zero mismatch case but did not exhibit the specific flow-related features as clearly. These results indicate that the impedance mismatch alters the acoustic environment inside the model and that this causes artifact in the Doppler spectra.
authors.affiliation: Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2196, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Jones
authors.forename: H
authors.initials: H
authors.lastname: Leclerc
authors.forename: G P
authors.initials: GP
authors.lastname: Chatzimavroudis
authors.forename: Y H
authors.initials: YH
authors.lastname: Kim
authors.forename: N A
authors.initials: NA
authors.lastname: Scott
authors.forename: A P
authors.initials: AP
authors.lastname: Yoganathan
mesh_terms: D001783:Blood Flow Velocity; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008953:Models, Anatomic; D018617:Ultrasonography, Doppler, Pulsed / Q000379:methods*