The type 3 serotonin receptor is expressed in a subpopulation of GABAergic neurons in the rat neocortex and hippocampus.
We used in situ hybridization and immunocytochemistry to investigate the presence of GABA in neurons that express the type 3 serotonin receptor (5-HT3R). Quantitative analysis indicated that more than 90% of 5-HT3R expressing cells are GABAergic in the neocortex and hippocampus. The co-existence of 5-HT3R and GABA in cortical and hippocampal neurons indicates that serotonin, via 5-HT3R, can affect GABA release and suggests the participation of 5-HT3R in the inhibitory regulation of forebrain neurons.
Morales
M
M
Scripps Research Institute, Department of Neuropharmacology, La Jolla, CA 92037, USA.
Battenberg
E
E
de Lecea
L
L
Bloom
F E
FE
D000679:Amygdala / Q000737:chemistry / Q000166:cytology; D000818:Animals; D002540:Cerebral Cortex / Q000737:chemistry / Q000166:cytology*; D018891:Dentate Gyrus / Q000737:chemistry / Q000166:cytology*; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007395:Interneurons / Q000737:chemistry* / Q000502:physiology; D008297:Male; D009830:Olfactory Bulb / Q000737:chemistry / Q000166:cytology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000032:analysis / Q000096:biosynthesis / Q000235:genetics*; D012686:Septal Nuclei / Q000737:chemistry / Q000166:cytology; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D011985:Receptors, Serotonin; D005680:gamma-Aminobutyric Acid