Growth in children after bone marrow transplantation for acute myelogenous leukemia as compared to acute lymphocytic leukemia.
Previous studies of growth in children following bone marrow transplantation for leukemia have demonstrated poor growth with little ability to "catch-up" two to four years after transplantation. Because of small patient numbers, these studies did not distinguish patients with differing types of leukemia. 12 children with acute myelogenous leukemia who survived over 3 years after transplantation were compared with 12 who survived transplantation for acute lymphoblastic leukemia. The initial height standard deviation scores were similar in both groups prior to transplantation. The height standard deviation scores in the acute lymphoblastic leukemia group decreased for each of the 5 years after transplantation while the height score for the acute myelogenous leukemia group after 5 years was not statistically different from pre-transplantation. The growth of the children with myelogenous leukemia was better possibly because these children were older, had received less cranial irradiation at the time of transplantation, and had a lower incidence of severe chronic graft-versus-host disease.
Alter
C A
CA
Division of Endocrinology, Children's Hospital of Philadelphia, USA.
Thornton
P S
PS
Willi
S M
SM
Bunin
N
N
Moshang
T
T
D000293:Adolescent; D000375:Aging; D001827:Body Height; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D016371:Cranial Irradiation; D005260:Female; D006086:Graft vs Host Disease; D006128:Growth; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000401:mortality / Q000628:therapy*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000401:mortality / Q000628:therapy*; D015996:Survival Rate