title: A potent mu-opioid receptor agonist, dihydroetorphine, fails to produce the conditioned place preference in mice.
abstract: Reinforcing effects of dihydroetorphine (DHE) and morphine were evaluated by the conditioned place preference paradigm. Both DHE and morphine produced an antinociceptive effect in a dose-dependent manner. On the other hand, DHE (0.1, 1, 3 and 10 micrograms/kg, i.p.) failed to induce the conditioned preference, while morphine (0.1, 1, 3 and 10 mg/kg, i.p.) caused a dose-dependent preference for the drug-paired place. Thus, these characteristic properties of DHE make it attractive for development as a novel potent analgesic compound that has less dependence liability.
authors.affiliation: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Tokuyama
authors.forename: F
authors.initials: F
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Nakao
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Kaneto
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D002755:Choice Behavior / Q000187:drug effects; D003216:Conditioning, Operant; D003213:Conditioning, Psychological / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005048:Etorphine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009021:Morphine Dependence / Q000503:physiopathology
chemical_list: D000701:Analgesics, Opioid; D005048:Etorphine; D009020:Morphine; C034765:18,19-dihydroetorphine