Overall and cause-specific mortality in a cohort of homo-/bisexual men, injecting drug users, and female partners of HIV-infected men. Pulmonary Complications of Human Immunodeficiency Virus Infection Study Group.
OBJECTIVE
To study the overall and cause-specific HIV-related mortality in a cohort of HIV-seropositive subjects according to transmission category, race/ethnicity, sex and severity of immunosuppression.


METHODS
A cohort of 1129 HIV-seropositive homo-/bisexual men, injecting drug users, and female partners of HIV-infected men were enrolled at six centers in San Francisco, Los Angeles, Chicago, Newark, Detroit and New York between 1 November 1988 and 1 November 1989. Subjects were evaluated every 6 months at least until 31 March 1994.


METHODS
The analyses of overall mortality for the subgroups of interest were performed with Kaplan-Meier plots and Cox proportional hazards models. Cause-specific analyses were performed on the primary cause of death using rates per 100 person-years of exposure.


CONCLUSIONS
Baseline severity of immunosuppression is the strongest predictor of mortality. There were no statistically significant differences in overall HIV-related mortality among transmission categories, race/ethnicity groups or sexes. There were differences, however, in cause-specific mortality among the different risk groups.
Poole
W K
WK
Research Triangle Institute, Research Triangle Park, NC, USA.
Fulkerson
W
W
Lou
Y
Y
Kvale
P
P
Hopewell
P C
PC
Hirschtick
R
R
Glassroth
J
J
Rosen
M
M
Mangura
B
B
Wallace
J
J
Markowitz
N
N
D017088:AIDS-Related Opportunistic Infections / Q000150:complications; D001727:Bisexuality; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000401:mortality* / Q000635:transmission; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D012747:Sexual Partners; D015819:Substance Abuse, Intravenous