Does minimizing neuroleptic dosage influence hyponatremia?
Neuroleptic dosage was reduced by 10% every 2 weeks in five male hyponatremic polydipsic patients with schizophrenia. Mean dose fell from 1980 +/- 1289 to 631 +/- 135 chlorpromazine equivalents/day over a mean of 12.2 weeks until behavioral relapse occurred. During this time, serum sodium did not vary from baseline levels (132.9 +/- 4.9 mEq/1), suggesting that minimizing neuroleptic dose does not alter the severity of hyponatremia in these patients.
Canuso
C M
CM
Department of Psychiatry, University of Chicago Pritzker School of Medicine, IL 60637, USA.
Goldman
M B
MB
D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000187:drug effects*; D006801:Humans; D007010:Hyponatremia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy; D014869:Water Intoxication / Q000150:complications
D014150:Antipsychotic Agents