Serum Mg2+ and Ca2+/Mg2+ ratio in major depressive disorder.
Serum Mg2+ has been implicated in the symptom severity and pathophysiology of mood disorders. Furthermore, the recent findings of blunted signalling through the G-protein-coupled adenylyl cyclase (AC) pathway in major depressive disorder (MDD) and the importance of Mg2+ in G-protein/AC function led us to reexamine in a large sample whether serum Mg2+ concentrations were decreased in MDD patients. In 145 drug-free MDD patients compared with 2 control groups: (a) patients with bipolar disorder (n = 33) and (b) non-mood-disordered patients (n = 47), there were no differences in Mg2+ levels or Ca2+/Mg2+ ratios. Neither of these measures differed when comparing responders and nonresponders to antidepressant treatment.
Young
L T
LT
Mood Disorders Program, McMaster University, Hamilton, Ont, Canada.
Robb
J C
JC
Levitt
A J
AJ
Cooke
R G
RG
Joffe
R T
RT
D000328:Adult; D002118:Calcium / Q000378:metabolism*; D003866:Depressive Disorder / Q000378:metabolism*; D005260:Female; D006801:Humans; D008274:Magnesium / Q000378:metabolism*; D008297:Male
D008274:Magnesium; D002118:Calcium