Effect of antioxidants on postoperative hyperamylasemia in coronary bypass surgery.
Antioxidants may reduce pancreatic cellular injury after coronary artery bypass grafting (CABG) Twenty patients (Group A) received vitamin E (600 mg/ day) for 28 days and vitamin C (2 g/day) and allopurinol (600 mg/day) 2 days before and 1 day after CABG. Seventeen patients (Group C) received all drugs for 3 days, and 25 (Group B) and 19 (Group D) patients served as corresponding controls. The pre- and postoperative pancreatic isoamylase (P-amylase), creatinine, and antioxidant concentrations were measured. Serum hyperamylasemia was highest on the first postoperative day and occurred in 73% of the patients. After surgery serum P-amylase increased in all study groups and urine P-amylase decreased. Postoperative serum hyperamylasemia, whether primarily renal or pancreatic, cannot be decreased by pretreatment with allopurinol, vitamin C, and vitamin E.
Paajanen
H
H
Department of Surgery, Tampere University Hospital, University of Tampere, Finland.
Harmoinen
A
A
Sisto
T
T
Tarkka
M
M
Metsä-Ketelä
T
T
Iovanna
J L
JL
Dagorn
J C
JC
Nordback
I H
IH
D000368:Aged; D000493:Allopurinol / Q000627:therapeutic use; D000681:Amylases / Q000097:blood*; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000201:enzymology; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D014810:Vitamin E / Q000627:therapeutic use
D000975:Antioxidants; D007527:Isoenzymes; D014810:Vitamin E; D000493:Allopurinol; D003404:Creatinine; D000681:Amylases; D001205:Ascorbic Acid