title: Supraglottic laryngectomy with postoperative radiation versus primary radiation in the management of supraglottic laryngeal cancer.
abstract: OBJECTIVE
  The purpose of this review was to study the results of horizontal partial laryngectomy (HPL) for supraglottic laryngeal cancer (stages N0 and N+) and the effects and morbidity of postoperative radiation therapy (RT), especially after bilateral neck dissection, as opposed to primary RT.
  
  
  METHODS
  Of a total of 89 patients, 26 were treated by HPL, 44 by primary RT, and 19 by total laryngectomy (TL). Of the HPL patients, 19 of 26 had neck dissection, 10 were bilateral. Twelve of the patients received postoperative RT, and 10 of 12 procedures were combined with neck dissection.
  
  
  RESULTS
  When comparing the results of HPL and primary RT, the locoregional control was equivalent for the N0 patients, but HPL showed better results in locoregional control for the N+ patients (P < .0024). Postoperative RT with or without bilateral neck dissection did not show an increase in postoperative morbidity.
  
  
  CONCLUSIONS
  Therefore, our data suggest that there should be no hesitation in giving postoperative RT where indicated, after performing HPL plus unilateral or bilateral neck dissection. Patients that are stage N0 should receive primary RT.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
authors.forename: R T
authors.initials: RT
authors.lastname: Gregor
authors.forename: S S
authors.initials: SS
authors.lastname: Oei
authors.forename: G
authors.initials: G
authors.lastname: Baris
authors.forename: R B
authors.initials: RB
authors.lastname: Keus
authors.forename: A J
authors.initials: AJ
authors.lastname: Balm
authors.forename: F J
authors.initials: FJ
authors.lastname: Hilgers
mesh_terms: D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D007013:Hypopharynx / Q000473:pathology / Q000601:surgery*; D007825:Laryngectomy; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D016896:Treatment Outcome