title: Glottic microinvasive carcinoma: is it different from carcinoma in situ?
abstract: OBJECTIVE
  To determine the impact of different treatment modalities on the outcome of microinvasive carcinoma.
  
  
  METHODS
  Retrospective review of patients presenting between 1976 and 1990.
  
  
  METHODS
  Fifteen patients with microinvasive carcinoma (MIC) of the glottic larynx treated at McGill University teaching hospitals.
  
  
  METHODS
  All patients had MIC involving the glottis confirmed pathologically. Nine patients (60%) had right vocal cord involvement, four (27%) had left vocal cord involvement, and two (13%) had involvement of both cords. Five patients (33%) were treated by stripping(S), three patients (20%) by stripping and radiotherapy (S + RT), and six patients (40%) by radiotherapy (RT) alone as the primary treatment. Only one patient underwent hemilaryngectomy.
  
  
  RESULTS
  With a median follow-up time of 63 months (range 20-208 months), the 15-year actuarial survival rate is 100% for all patients.
  
  
  CONCLUSIONS
  Surgery alone, RT alone, or S + RT is equally effective in treating MIC of the glottic larynx; however, single-modality therapy is preferred. The choice of treatment modality should be individualized for each patient.
authors.affiliation: Department of Oncology, McGill University Faculty of Medicine, Québec.
authors.forename: C
authors.initials: C
authors.lastname: Nguyen
authors.forename: B
authors.initials: B
authors.lastname: Naghibzadeh
authors.forename: M J
authors.initials: MJ
authors.lastname: Black
authors.forename: L
authors.initials: L
authors.lastname: Rochon
authors.forename: G
authors.initials: G
authors.lastname: Shenouda
mesh_terms: D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000473:pathology*; D005260:Female; D005931:Glottis / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies; D015996:Survival Rate; D014827:Vocal Cords / Q000473:pathology / Q000601:surgery; D014833:Voice Quality