Prenatal hypoxia alters the postnatal development of beta-adrenoceptors in the rat myocardium.
The effect of prenatal hypoxia on the development of the beta-adrenoceptor during the ontogenesis of rats was investigated. It was shown that the offspring from hypoxic dams, in comparison with normoxic control animals, exhibited alterations of the density (Bmax) of the myocardial beta-receptors and of the catecholamine levels in heart tissue during development. The results suggest that the beta-adrenoceptor changes might be involved in the phenomenon of enhanced sensitivity of prenatal hypoxic animals to catecholamines in adult age.
Roigas
J
J
Department of Biochemistry, Humboldt University Medical School (Charité), Berlin, Germany.
Roigas
C
C
Heydeck
D
D
Papies
B
B
D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D005260:Female; D005311:Fetal Hypoxia / Q000503:physiopathology*; D007700:Kinetics; D009206:Myocardium / Q000378:metabolism*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D002395:Catecholamines; D011943:Receptors, Adrenergic, beta