Determination of the steady state tissue distribution of midazolam in the rat.
The aim of this study was to determine the steady state tissue:blood (Kb), tissue:plasma (Kp), and tissue:plasma water (Ku) partition coefficients of midazolam in all major organs and tissues in the rat, after development of a gas chromatographic assay. The Kp in 12 tissues ranged between 1.3 (in muscle) and 9.0 (in fat). Ku ranged correspondingly between 16 and 115.
Björkman
S
S
Hospital Pharmacy, Malmö University Hospital, Sweden.
Fyge
A
A
Qi
Z
Z
D000818:Animals; D001682:Biological Availability; D002849:Chromatography, Gas; D008874:Midazolam / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D014018:Tissue Distribution
D008874:Midazolam