Lymphocyte subset diversity in idiopathic CD4+ T lymphocytopenia.
The clinical and public health importance of CD4+ T lymphocytopenia without human immunodeficiency virus infection is still unclear. We describe herein two new human immunodeficiency virus-negative patients with low numbers of peripheral CD4+ T cells and opportunistic infections (cerebral toxoplasmosis and tuberculosis plus extrapulmonary histoplasmosis). The low numbers of CD4+ CD29+ memory cells, the high percentage of gamma delta T-cell receptor cells, and the recovery of CD4+ cells after treatment were remarkable.
Tassinari
P
P
Instituto de Immunología, Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela.
Deibis
L
L
Bianco
N
N
Echeverría de Pérez
G
G
D000328:Adult; D015704:CD4 Antigens / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D005260:Female; D006801:Humans; D019012:Integrin beta1 / Q000276:immunology; D008297:Male; D008875:Middle Aged; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D018344:T-Lymphocytopenia, Idiopathic CD4-Positive / Q000276:immunology* / Q000628:therapy
D015704:CD4 Antigens; D019012:Integrin beta1; D016692:Receptors, Antigen, T-Cell, gamma-delta