title: [Semiquantitative detection of pain and heat sensations in evaluation of contrast media in pelvic/leg angiography. Intraindividual double-blind study with iomeprol 350 and iopentol 350].
abstract: The effect on pain and heat sensation of monomere non-ionic contrast media with different osmolality was assessed in a randomized double-blind study. Peripheral angiography was performed in 29 patients who suffered from chronic occlusive vessel disease. The two non-ionic contrast media iomeprol and iopentol were applied intraindividually. The contrast media with an iodine concentration of 350 mg/ml had an osmolality of 618 or 810 mosm/kg. A contrast medium volume of 80 or 90 ml was injected in the abdominal aorta. The mean flow was 13.9 ml/s. The two contrast medium injections were separated by an interval of 10 min. No analgesic premedication was given. The pain and heat intensity was semiquantatively measured using a visual analogue scale ranging from 0 (no heat/pain) to 100 (intractable heat/pain). The median after the first injection was calculated as 40 for iomeprol and 70 for iopentol. The comparison of heat and pain sensations after the second injection showed a less distinct difference with a scale rating of 60 for iomeprol and of 65 for iopentol. The statistical variance was highly significant (p < 0.01) in favor of iomeprol.
authors.forename: K
authors.initials: K
authors.lastname: Mathias
authors.forename: U
authors.initials: U
authors.lastname: Kempkes
authors.forename: E
authors.initials: E
authors.lastname: Schmiedel
mesh_terms: D000328:Adult; D000792:Angiography; D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects*; D004311:Double-Blind Method; D006801:Humans; D007479:Iopamidol / Q000009:adverse effects / Q000031:analogs & derivatives*; D007511:Ischemia / Q000000981:diagnostic imaging; D007866:Leg / Q000098:blood supply*; D009994:Osmolar Concentration; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects*; D013697:Thermosensing / Q000187:drug effects*; D014283:Triiodobenzoic Acids / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; C057937:iomeprol; C053571:iopentol; D007479:Iopamidol