Effects of dimethindene maleate on psychomotor performance in the oculodynamic test compared with placebo and loratadine.
The effects of dimethindene maleate (CAS 3614-69-5) on the central nervous system-as sustained release pellets (Fenistil OAD; OAD = once a day) and sustained release tablets (Fenistil retard) with an immediate release fraction-were investigated by means of the oculodynamic test (ODT) and visual analogue scales and compared to loratadine (CAS 79794-75-5) and placebo. In the confirmatory part of the study 18 healthy volunteers were included in a single-blind, randomised, 3-way change-over design with Fenistil OAD, loratadine, and placebo. An additional, fourth exploratory arm with Fenistil retard was run in 6 (out of the 18) subjects after completing the main part of the study. The ODT includes electro-oculography, choice reaction task, and cardiologic parameters under workload. Visual analogue scales were used for subjective ratings on well-being and drug effects concerning wakefulness (sedation), excitation, dizziness, performance, effort, and dry mouth. The results show no relevant differences between either of the active drugs and placebo. Therefore it can be stated that after a single dose there is no sedating effect of dimethindene maleate compared to loratadine or placebo.
Englisch
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W
Zyma GmbH, Munich, Germany.
Rehn
D
D
Schaffler
K
K
Wauschkuhn
C H
CH
D000328:Adult; D002940:Circadian Rhythm / Q000187:drug effects; D003692:Delayed-Action Preparations; D004115:Dimethindene / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D004585:Electrooculography / Q000187:drug effects; D005133:Eye Movements / Q000187:drug effects*; D005260:Female; D005403:Fixation, Ocular / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D017336:Loratadine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011597:Psychomotor Performance / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D016037:Single-Blind Method; D014851:Wakefulness / Q000187:drug effects
D003692:Delayed-Action Preparations; D006634:Histamine H1 Antagonists; D004115:Dimethindene; D017336:Loratadine