Metabolic engineering of sugar catabolism in lactic acid bacteria.
Lactic acid bacteria are characterized by a relatively simple sugar fermentation pathway that, by definition, results in the formation of lactic acid. The extensive knowledge of traditional pathways and the accumulating genetic information on these and novel ones, allows for the rerouting of metabolic processes in lactic acid bacteria by physiological approaches, genetic methods, or a combination of these two. This review will discuss past and present examples and future possibilities of metabolic engineering of lactic acid bacteria for the production of important compounds, including lactic and other acids, flavor compounds, and exopolysaccharides.
de Vos
W M
WM
Department of Biophysical Chemistry, NIZO, Ede, The Netherlands.
D001692:Biological Transport; D050260:Carbohydrate Metabolism; D005285:Fermentation; D005818:Genetic Engineering; D019344:Lactic Acid / Q000378:metabolism*; D007778:Lactobacillus / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System / Q000378:metabolism; D011135:Polysaccharides, Bacterial / Q000096:biosynthesis; D019289:Pyruvic Acid / Q000378:metabolism; D013289:Streptococcaceae / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*
D011135:Polysaccharides, Bacterial; D019344:Lactic Acid; D019289:Pyruvic Acid; D010088:Oxidoreductases; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System