title: Nucleoli and argyrophil nucleolus organizer regions (AgNORs) of cells of the megakaryocytic line in the rat.
abstract: The main maturation stages of Norway rat megakaryocytic series, megakaryoblasts and mature megakaryocytes, stained by silver for demonstration of argyrophil nucleolus organizer regions (AgNORs) were investigated to provide basic information on the number of nucleoli and interphasic AgNORs in these cells. The results showed that megakaryoblasts as well as mature megakaryocytes possess numerous nucleoli; their number and also the number of AgNORs is significantly higher in less mature than in more mature cells. The number of AgNORs in megakaryocytes of the Norway rat and man are virtually the same, although the numbers of nucleolar organizers per haploid chromosome set differ markedly. This fact leads to the conclusion that the number of interphasic AgNORs depends on the function and metabolic state of the cell rather than on the number of nucleolar organizers.
authors.affiliation: Institute of Histology and Embryology, Charles University, Prague, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Janoutová
authors.forename: Z
authors.initials: Z
authors.lastname: Likovský
mesh_terms: D000818:Animals; D002460:Cell Line; D002466:Cell Nucleolus / Q000648:ultrastructure*; D016922:Cellular Senescence; D008297:Male; D008533:Megakaryocytes / Q000648:ultrastructure*; D009697:Nucleolus Organizer Region / Q000648:ultrastructure*; D051381:Rats; D017208:Rats, Wistar; D012834:Silver; D013194:Staining and Labeling
chemical_list: D012834:Silver