p53 mutation is associated with high S-phase fraction in primary fallopian tube adenocarcinoma.
Fallopian tube carcinoma (FTC) is a rare but lethal gynaecological malignancy. Four out of seven FTCs were identified with three point missense mutations, one single base deletion and one silent point mutation in the p53 gene. Genital-type HPV sequences were not detected. The S-phase fraction of tumours with mutant and wild-type p53 was 25.74% (median) and 12.55% (median) respectively.
Runnebaum
I B
IB
Department of Obstetrics and Gynaecology, University of Ulm, Germany. ingo.runnebaum@medizin.uni-ulm.de
Köhler
T
T
Stickeler
E
E
Kieback
H R
HR
Kreienberg
R
R
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology*; D000368:Aged; D005185:Fallopian Tube Neoplasms / Q000235:genetics* / Q000473:pathology*; D005260:Female; D016158:Genes, p53; D006801:Humans; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism; D009367:Neoplasm Staging; D027383:Papillomaviridae / Q000235:genetics; D017354:Point Mutation; D016196:S Phase / Q000502:physiology*; D016662:Virus Integration
D009363:Neoplasm Proteins