Effects of histamine on gizzard erosions and on the activity of selected enzymes in chickens.
Dose- (5, 10 and 15 mg/kg body mass) and time-dependent (2, 6, 12 and 24 h after treatment) effects of histamine on gizzard lesions and serum AST, ALT and CK activities of chickens are reported. Morphometric results and histopathological examination revealed that the most effective histamine dose which induced severe gizzard lesions was 10 mg/kg b.m., especially 2, 6 and 12 h after administration. No difference from the control values was found after 24 h. That dose also induced an elevation of serum enzyme (AST, ALT, CK) activities, which was most expressed for the activity of ALT.
Dzaja
P
P
Department of Forensic Veterinary Medicine, University of Zagreb, Croatia.
Grabarević
Z
Z
Perić
J
J
Artuković
B
B
Tisljar
M
M
Mrljak
V
V
Sostarić
E
E
D000410:Alanine Transaminase / Q000097:blood*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood*; D002645:Chickens / Q000097:blood*; D003402:Creatine Kinase / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D005895:Gizzard, Avian / Q000187:drug effects* / Q000502:physiology; D006632:Histamine / Q000494:pharmacology*; D013997:Time Factors
D006632:Histamine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase