title: Induction and differentiation of extra-embryonic mesoderm in the mouse.
abstract: Extra-embryonic mesoderm, derived at the time of gastrulation from the primitive streak, gives rise to several tissues that function to provide the embryo with nutrients, a means of waste disposal, and mechanical protection. Little is known about the differentiation of this tissue and about the growth and transcription factors involved. The present review focussed on growth and transcription factors that may be involved in differentiation of extra-embryonic mesoderm, and results from fate-mapping and transplantation studies. Methods in vitro available for assaying the effects of growth and transcription factors on development of extra-embryonic development are also discussed.
authors.affiliation: Laboratory of Radiobiology and Environmental Health, University of California, San Francisco 94143-0750, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Boucher
authors.forename: R A
authors.initials: RA
authors.lastname: Pedersen
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004624:Embryo Transfer; D004627:Embryonic Induction; D005775:Gastrula / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D006133:Growth Substances / Q000235:genetics* / Q000502:physiology; D008648:Mesoderm / Q000166:cytology / Q000502:physiology*; D051379:Mice; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology
chemical_list: D006133:Growth Substances; D014157:Transcription Factors