title: Ligneous conjunctivitis in four Doberman pinschers.
abstract: Ligneous conjunctivitis (LC) was diagnosed in four unrelated Doberman pinschers. Thick, opaque membranes of the palpebral conjunctivae and nictitating membranes were present bilaterally. Three dogs had concurrent signs of multisystemic disease. A thick, amorphous, eosinophilic, hyaline-like material in the substantia propria of the conjunctiva--containing a moderate, mononuclear cell infiltrate--was evident on histological examination. A predominance of T lymphocytes, few macrophages, and weak positive staining for immunoglobulin G (IgG) and immunoglobulin A (IgA) were evident by immunohistochemical staining. The clinical and histological appearance of LC in Doberman pinschers and humans is similar.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824-1314, USA.
authors.forename: D T
authors.initials: DT
authors.lastname: Ramsey
authors.forename: K L
authors.initials: KL
authors.lastname: Ketring
authors.forename: M B
authors.initials: MB
authors.lastname: Glaze
authors.forename: B
authors.initials: B
authors.lastname: Knight
authors.forename: J A
authors.initials: JA
authors.lastname: Render
mesh_terms: D000418:Albumins / Q000032:analysis / Q000378:metabolism; D000818:Animals; D003228:Conjunctiva / Q000737:chemistry / Q000473:pathology; D003231:Conjunctivitis / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D003315:Cornea / Q000737:chemistry / Q000473:pathology; D004283:Dog Diseases / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D004285:Dogs; D005260:Female; D005337:Fibrin / Q000032:analysis / Q000378:metabolism; D006025:Glycosaminoglycans / Q000032:analysis / Q000378:metabolism; D007070:Immunoglobulin A / Q000032:analysis / Q000378:metabolism; D007074:Immunoglobulin G / Q000032:analysis / Q000378:metabolism; D007150:Immunohistochemistry; D008264:Macrophages / Q000737:chemistry / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron / Q000662:veterinary; D013601:T-Lymphocytes / Q000737:chemistry / Q000473:pathology
chemical_list: D000418:Albumins; D006025:Glycosaminoglycans; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D005337:Fibrin