Flumazenil, diazepam, nordiazepam and oxazepam interactions on plasma protein binding.
The effect of flumazenil (FLU) on plasma protein binding of diazepam (DZ), nordiazepam (ND) and oxazepam (OX) was determined in plasma from drug-naive dogs to which graded concentrations of tested drugs alone and in combination were added. The results revealed that as the concentration of FLU added to plasma alone was increased its binding with plasma proteins decreased and that there were no significant binding interactions between FLU and OX, ND and DZ.
Wala
E P
EP
Department of Anesthesiology, University of Kentucky, Lexington 40536-0216, USA.
Sloan
J W
JW
D000818:Animals; D014151:Anti-Anxiety Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D001711:Biotransformation; D001798:Blood Proteins / Q000378:metabolism*; D003975:Diazepam / Q000493:pharmacokinetics / Q000494:pharmacology; D004285:Dogs; D004347:Drug Interactions; D005442:Flumazenil / Q000493:pharmacokinetics / Q000494:pharmacology; D066298:In Vitro Techniques; D003708:Nordazepam / Q000493:pharmacokinetics / Q000494:pharmacology; D010076:Oxazepam / Q000493:pharmacokinetics / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects
D014151:Anti-Anxiety Agents; D001798:Blood Proteins; D005442:Flumazenil; D003708:Nordazepam; D010076:Oxazepam; D003975:Diazepam