Hyperestrogenemia and presence of estrogen receptors associated with an epithelial ovarian tumor of low malignant potential.
An 80-year-old woman presented with breast congestion, tenderness and pain. Mammography was normal. Circulating estradiol was markedly elevated, while LH and FSH were low. Pelvic examination and imaging revealed an ovarian mass which was extirpated during total abdominal hysterectomy and bilateral salpingo-oophorectomy. Histopathology revealed an ovarian mucinous cystadenocarcinoma of low malignant potential, stage 1. The tumor was positively stained for estrogen receptors. Estradiol levels returned to normal post-operatively, with a corresponding adjustment of LH/FSH. Possible autocrine steroid production is discussed.
Ben-Hur
H
H
Department of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel.
Dgani
R
R
Insler
V
V
Lifschitz-Mercer
B
B
Blickstein
I
I
Mor
G
G
Kohen
F
F
Shani
A
A
Biran
H
H
D000368:Aged; D000369:Aged, 80 and over; D018282:Cystadenocarcinoma, Mucinous / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009376:Neoplasms, Hormone-Dependent / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D011960:Receptors, Estrogen / Q000032:analysis*
D011960:Receptors, Estrogen; D004958:Estradiol