title: Nasal mucosal thickening simulating a tumor: potential for misdiagnosis in brain perfusion imaging.
abstract: A 33-year-old, female presenting with dementia was admitted to our institution. Except for slight muscle atrophy noted on both lower extremities there were no other significant physical signs or laboratory findings. Since initial Tc-99m HMPAO SPECT showed hypoperfusion on both temporal, parietal and occipital lobes, follow up study with the same radiotracer was done. Increase in uptake was noted in the left side of the face. There was no abnormality noted on ENT examination. CT scan and MRI showed slight nasal mucosal wall thickening. T1-201 SPECT showed increased uptake in the nasal area. The increase in uptake could be due to nasal mucosal thickening. This could simulate nasal tumor and interfere in determining ROI for brain perfusion studies.
authors.affiliation: Department of Radiology, Miyazaki Medical College, Japan.
authors.forename: L G
authors.initials: LG
authors.lastname: Flores
authors.forename: S
authors.initials: S
authors.lastname: Jinnouchi
authors.forename: S
authors.initials: S
authors.lastname: Nagamachi
authors.forename: T
authors.initials: T
authors.lastname: Ohnishi
authors.forename: S
authors.initials: S
authors.lastname: Futami
authors.forename: Y
authors.initials: Y
authors.lastname: Okuda
authors.forename: N
authors.initials: N
authors.lastname: Tsuru
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology; D003704:Dementia; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009297:Nasal Mucosa / Q000473:pathology*; D009669:Nose Neoplasms; D009778:Occipital Lobe / Q000098:blood supply / Q000000981:diagnostic imaging; D015609:Organotechnetium Compounds; D010091:Oximes; D010296:Parietal Lobe / Q000098:blood supply / Q000000981:diagnostic imaging; D013132:Spinocerebellar Degenerations / Q000000981:diagnostic imaging* / Q000235:genetics; D019690:Technetium Tc 99m Exametazime; D013702:Temporal Lobe / Q000098:blood supply / Q000000981:diagnostic imaging; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime