title: Minocycline-induced discolouration of the sclerae.
abstract: We report two patients with minocycline-induced pigmentation of the sclerae. Cutaneous pigmentation is a well-recognized complication of minocycline therapy, but only five cases of pigmentation of the sclerae have been described previously. These five patients have a number of features in common with the two reported here. We propose that these patients represent the most severe end of the spectrum of minocycline-induced cutaneous changes. Patients should be warned about the possibility of the occurrence of pigmentary changes before starting therapy.
authors.affiliation: Department of Dermatology, Bristol Royal Infirmary, U.K.
authors.forename: R A
authors.initials: RA
authors.lastname: Sabroe
authors.forename: C B
authors.initials: CB
authors.lastname: Archer
authors.forename: D
authors.initials: D
authors.lastname: Harlow
authors.forename: J W
authors.initials: JW
authors.lastname: Bradfield
authors.forename: R D
authors.initials: RD
authors.lastname: Peachey
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008911:Minocycline / Q000009:adverse effects*; D010859:Pigmentation Disorders / Q000139:chemically induced*; D015422:Scleral Diseases / Q000139:chemically induced*
chemical_list: D000900:Anti-Bacterial Agents; D008911:Minocycline