title: [Combination therapy with 5-fluorouracil (5-FU), cisplatin (CDDP) and interferon alpha-2B (IFN alpha-2B) for advanced renal cell carcinoma].
abstract: Eleven patients with metastatic renal cell carcinoma received combination therapy with 5-fluorouracil (5-FU), Cisplatin (CDDP) and Interferon alpha-2b (IFN alpha-2b). For 5 days, 500 mg of 5-FU was administered by continuous intravenous infusion daily; 20 mg/m2 CDDP was injected intravenously daily for 5 days, and 3 or 6 million units of IFN alpha-2b was administered intramuscularly twice a week for 3 weeks. This treatment cycle was repeated every 3 weeks. One of 11 patients achieved a partial response, and the response rate was 9%. High grade toxicities (WHO grade 3 or 4), nausea and vomiting (27%), leukocytopenia (9%), anemia (9%) and thrombocytopenia (18%) were seen. One of the reasons that this regimen dose not appear to be effective may be the low total dose of 5-FU for renal cell carcinoma.
authors.affiliation: Dept. of Urology, Kanagawa Cancer Center.
authors.forename: K
authors.initials: K
authors.lastname: Fujinami
authors.forename: I
authors.initials: I
authors.lastname: Ikeda
authors.forename: T
authors.initials: T
authors.lastname: Miura
authors.forename: I
authors.initials: I
authors.lastname: Kondo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000139:chemically induced; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007262:Infusions, Intravenous; D007273:Injections, Intramuscular; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects; D007680:Kidney Neoplasms / Q000628:therapy*; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D011994:Recombinant Proteins; D013921:Thrombocytopenia / Q000139:chemically induced; D014839:Vomiting / Q000139:chemically induced
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D002945:Cisplatin; D005472:Fluorouracil