title: Heterogeneity among juvenile antisocial behaviours: findings from the Virginia Twin Study of Adolescent Behavioural Development.
abstract: The examination of heterogeneity in antisocial behaviour was accomplished by applying latent class analytic methods to multivariate categorical data on 389 same-sex male twins, aged 11 to 16 from the Virginia Twin Study of Adolescent Behavioural Development (VTSABD). The data included multiple measures of oppositional and conduct disorder, attention deficit disorder, hyperactivity, impulsivity, reading disability and anxiety from mother, teacher, and child report from both questionnaire and interview (child and adult psychiatric assessment; CAPA). A latent four-class model provided a good fit to the data and yielded four phenotypically and aetiologically distinct latent classes: (1) a non-symptomatic class influenced by both additive genetic and shared environmental factors; (2) a hyperactivity-conduct disturbance class accounted for by both additive and non-additive genetic effects; (3) a 'pure' conduct disturbance class with a very strong shared environmental component; and (4) a multisymptomatic class explained entirely by the additive effect of the genes. Further characterization of these four latent classes by age of the child and parental psychiatric history is also shown.
authors.affiliation: Department of Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA.
authors.forename: J
authors.initials: J
authors.lastname: Silberg
authors.forename: J
authors.initials: J
authors.lastname: Meyer
authors.forename: A
authors.initials: A
authors.lastname: Pickles
authors.forename: E
authors.initials: E
authors.lastname: Simonoff
authors.forename: L
authors.initials: L
authors.lastname: Eaves
authors.forename: J
authors.initials: J
authors.lastname: Hewitt
authors.forename: H
authors.initials: H
authors.lastname: Maes
authors.forename: M
authors.initials: M
authors.lastname: Rutter
mesh_terms: D000293:Adolescent; D000987:Antisocial Personality Disorder / Q000235:genetics*; D002648:Child; D006801:Humans; D008297:Male; D011153:Population