Acute stimulant response prediction of chronic trazodone effects.
1. Depressed patients who acutely improve after taking a stimulant drug have a better eventual response to chronic antidepressant treatment than do stimulant non-responders. Unlike the stimulants and most antidepressants, trazodone (TRZ) is not a potent monoamine reuptake inhibitor. 2. The authors tested the hypothesis that acute methylphenidate (MPH) and d-amphetamine (d-AMP) response would not correlate with eventual trazodone response because its site of action was different from other antidepressants. 3. It was found that acute MPH-induced improvement correlated with eventual TRZ-induced improvement to a limited degree. 4. This correlation might reflect serotonin reuptake inhibition by trazodone and suggests that this effect is therapeutically relevant.
Little
K Y
KY
Department of Psychiatry, University of Michigan, Ann Arbor, USA.
Gay
T L
TL
D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D000697:Central Nervous System Stimulants; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D003913:Dextroamphetamine; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate; D008875:Middle Aged; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D014196:Trazodone / Q000627:therapeutic use*
D018687:Antidepressive Agents, Second-Generation; D000697:Central Nervous System Stimulants; D008774:Methylphenidate; D003913:Dextroamphetamine; D014196:Trazodone