[Surgical therapy and prognosis of not curatively resectable rectum carcinoma. Results of a multicenter study of the Colorectal Carcinoma Study Group].
The prospective multicenter observation study of the SGCRC found in 1121 rectal carcinomas a resection rate of 94.2% with 79.1% curative resections (R0), 3.1% R1 resections and 11.7% R2 resections. The reasons for non-curative resections were multimorbidity preventing tumor resection, distant metastasis or locally advanced primary tumors. The prognosis following non curative surgery for rectum carcinoma depends on resectability, synchrone distant metastases and R classification (according to UICC). Additional therapy (chemo- and radiotherapy) may improve short time survival after non-curative resections in presence of distant metastases. After non-resective surgery local tumor destruction (laser, kryotherapy) is possibly an useful additional therapy. The indications for multimodal therapies are discussed and the development of uniform therapeutical strategies is required.
Riedl
S
S
Chirurgische Universitätsklinik Heidelberg.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010166:Palliative Care; D011379:Prognosis; D012004:Rectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate