Effects of preweaning sensorimotor stimulation on behavioral and neuronal development in motor and visual cortex of the rat.
The present study investigates the effects of early sensorimotor stimulation on behavioral and neuronal cytodifferentiation in motor and visual cortex of lactating rats. Seventy-two male and female Sprague-Dawley albino rats were systematically submitted to environmental stimulation during the early postnatal period (postnatal days 5-21). On postnatal day 22, four behavioral tests were performed (open field, narrow path crossing, hind limb support and ascending on a rope). In order to evaluate dynamic neuronal changes induced by sensorimotor enrichment, brains were stained through the Golgi-Cox-Sholl method. Morphometric studies were carried out in pyramidal neurons located in motor and visual cortical layers II and III, by measuring their basal dendritic length and branching. Further, wide cortical field studies were performed with the aim of evaluating the degree of development reached by clusters of pyramidal cells. The results indicate that sensorimotor stimulation carried out during the suckling period produced a significant increase in neuronal cytodifferentiation as observed in single cell studies. However, collective neuronal evaluations yielded less significant results. Consistently, rats exposed to enriched environments showed a better performance in behavioral adaptive responses.
Pascual
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R
Faculty of Health Sciences, Catholic University of Maule, Talca, Chile.
Figueroa
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H
D000818:Animals; D000833:Animals, Suckling; D001522:Behavior, Animal / Q000502:physiology*; D002454:Cell Differentiation; D003712:Dendrites / Q000648:ultrastructure; D004777:Environment; D005260:Female; D008297:Male; D009044:Motor Cortex / Q000254:growth & development* / Q000502:physiology / Q000648:ultrastructure; D009474:Neurons / Q000502:physiology* / Q000648:ultrastructure; D051381:Rats; D017207:Rats, Sprague-Dawley; D014793:Visual Cortex / Q000254:growth & development* / Q000502:physiology / Q000648:ultrastructure