Neuroprotective effect of TTC-909, an isocarbacyclin methyl ester incorporated in lipid microspheres, on hippocampal delayed neuronal death of stroke-prone spontaneously hypertensive rats.
TTC-909 is a newly developed isocarbacyclin methyl ester (TEI-9090) incorporated in lipid microspheres. The neuroprotective effect of TTC-909 was histologically examined in the pyramidal cell layer of the hippocampus CA1 subfield 7 days after transient forebrain ischemia using stroke-prone spontaneously hypertensive rats. TTC-909, given intravenously 10 min after the transient forebrain ischemia, dose-dependently protected against ischemia-related delayed neuronal death. The blood pressure remained unchanged following TTC-909 administration. This finding suggests that TTC-909 has a neuroprotective action on ischemic delayed neuronal death in the hippocampus.
Yamashita
K
K
Department of Pharmacology, Nagasaki University School of Medicine, Japan.
Kataoka
Y
Y
Nakashima
M N
MN
Yamashita
Y S
YS
Tanabe
H
H
Araki
H
H
Niwa
M
M
Taniyama
K
K
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002545:Brain Ischemia; D002452:Cell Count / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects*; D008297:Male; D008863:Microspheres; D009474:Neurons / Q000473:pathology; D018696:Neuroprotective Agents; D017966:Pyramidal Cells / Q000166:cytology / Q000187:drug effects; D051381:Rats; D011918:Rats, Inbred SHR
D018696:Neuroprotective Agents; C068518:TTC 909; D011464:Epoprostenol