title: Superovulation and intrauterine insemination vs. superovulation alone in the treatment of unexplained infertility. A randomized study.
abstract: OBJECTIVE
  To assess whether intrauterine insemination (IUI) improves the fertility rates in women with unexplained infertility.
  
  
  METHODS
  We recruited 68 women with unexplained infertility and allocated them randomly to treatment with three to five cycles of superovulation plus IUI (36 patients) or superovulation alone (32 patients). Superovulation was obtained with clomiphene citrate, human menopausal gonadotropins and human chorionic gonadotropins.
  
  
  RESULTS
  The cycle fecundity rate was 10% in patients who underwent superovulation alone and 19% in those treated with superovulation plus IUI (P < .05).
  
  
  CONCLUSIONS
  Our results demonstrate that superovulation plus IUI is more effective than superovulation alone in the treatment of unexplained infertility.
authors.affiliation: VIIth Department of Obstetrics and Gynecology, L Sacco Hospital, Milan, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Arcaini
authors.forename: S
authors.initials: S
authors.lastname: Bianchi
authors.forename: A
authors.initials: A
authors.lastname: Baglioni
authors.forename: M
authors.initials: M
authors.lastname: Marchini
authors.forename: L
authors.initials: L
authors.lastname: Tozzi
authors.forename: L
authors.initials: L
authors.lastname: Fedele
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D002996:Clomiphene / Q000627:therapeutic use; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D007315:Insemination, Artificial / Q000379:methods*; D008596:Menotropins / Q000627:therapeutic use; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D013480:Superovulation
chemical_list: D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D002996:Clomiphene; D008596:Menotropins