Stereoselectivity in drug metabolism and action: effects of enzyme inhibition and induction.
Many synthetic drugs that contain a chiral center are marketed as racemates. Taking into account the composite nature of chiral rugs has improved our understanding of the dose/effect relationship of these compounds. It is widely accepted that drug metabolism is often responsible for stereoselective disposition and hence factors modulating the activity of drug-metabolizing enzymes can modify this effect. The present article highlights the influence of some of these factors (induction and inhibition of drug-metabolizing enzymes) on stereoselective drug disposition. The latter topic includes an enantiomer/enantiomer interaction that alters drug disposition and drug action.
Kroemer
H K
HK
Dr. Margarete Fischer-Bosch-Institut für Klinische Pharmakologie, Stuttgart, Germany.
Fromm
M F
MF
Eichelbaum
M
M
D004347:Drug Interactions; D004790:Enzyme Induction / Q000502:physiology*; D004791:Enzyme Inhibitors / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008968:Molecular Conformation; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000378:metabolism; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D004364:Pharmaceutical Preparations