title: Apraclonidine 0.5% versus 1% for controlling intraocular pressure elevation after argon laser trabeculoplasty.
abstract: OBJECTIVE
  Topical apraclonidine hydrochloride 1% is effective for controlling the intraocular pressure (IOP) rise following argon laser trabeculoplasty (ALT). The 0.5% formulation has recently become available commercially. The objective of this study was to compare the efficacy of these two concentrations for controlling IOP after ALT.
  
  
  METHODS
  All patients undergoing ALT were prospectively randomized to receive either 1% or 0.5% apraclonidine 1 hour before and immediately after the laser surgery. IOP was measured before and 2 and 24 hours after the treatment.
  
  
  RESULTS
  No statistically significant difference in mean IOPs was found between the two treatment groups at any time.
  
  
  CONCLUSIONS
  These data suggest that 0.5% and 1% apraclonidine are equally effective for preventing IOP rise after ALT.
authors.affiliation: Duke University Eye Center, Durham, NC 27710, USA.
authors.forename: A B
authors.initials: AB
authors.lastname: Threlkeld
authors.forename: A A
authors.initials: AA
authors.lastname: Assalian
authors.forename: R R
authors.initials: RR
authors.lastname: Allingham
authors.forename: M B
authors.initials: MB
authors.lastname: Shields
mesh_terms: D000287:Administration, Topical; D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage*; D003000:Clonidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005500:Follow-Up Studies; D005901:Glaucoma / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D053685:Laser Therapy; D009798:Ocular Hypertension / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D009883:Ophthalmic Solutions; D011183:Postoperative Complications / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D011446:Prospective Studies; D014130:Trabeculectomy / Q000009:adverse effects*
chemical_list: D000316:Adrenergic alpha-Agonists; D009883:Ophthalmic Solutions; C016986:apraclonidine; D003000:Clonidine