Inhibition by bosentan, an endothelin antagonist, of the hypersensitivity to Ca2+ channel activator evoked by salt-loading in basilar artery of stroke-prone spontaneously hypertensive rats.
High salt diet dramatically decreases the life time of spontaneously hypertensive stroke-prone rats (SHRSP). This has been related to an increase in the incidence of stroke. We have investigated the influence of high salt diet on the reactivity to the Ca2+ channel activator Bay K 8644 of basilar artery isolated from SHRSP. The results show that the sensitivity of basilar artery to Bay K 8644 was increased by salt load and that this hypersensitivity was blunted by bosentan, an ETA/ETB antagonist.
Salomone
S
S
Laboratoire de Pharmacologie, Université Catholique de Louvain, Brussels, Belgium.
Dessy
C
C
Morel
N
N
Godfraind
T
T
D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000494:pharmacology*; D000818:Animals; D001488:Basilar Artery / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D000077300:Bosentan; D002120:Calcium Channel Agonists / Q000494:pharmacology*; D065128:Endothelin Receptor Antagonists; D009119:Muscle Contraction / Q000187:drug effects; D051381:Rats; D011918:Rats, Inbred SHR; D012965:Sodium Chloride / Q000008:administration & dosage* / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology*
D002120:Calcium Channel Agonists; D065128:Endothelin Receptor Antagonists; D013449:Sulfonamides; D012965:Sodium Chloride; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D000077300:Bosentan