Angiotensin I converting enzyme gene polymorphism and coronary heart disease.
Genetic variations in the renin-angiotensin and kallikrein-kinin systems could prove to be significant pathophysiological mechanisms affecting coronary heart disease (CHD), particularly given the powerful vasoactivity of products such as angiotensin II and bradykinin. Indeed, studies show that angiotensin converting enzyme (ACE) gene polymorphism is associated with an increased risk of myocardial infarction and death, even in otherwise low-risk subjects. Genetic differences do not appear to be a risk factor for atherosclerosis or hypertension, however. Because ACE polymorphism modulates local production of angiotensin II, a powerful coronary vasoconstrictor, it may influence left ventricular mass in general as well as in coexisting disease states such as hypertension and cardiomyopathy. However, further study is needed to clarify the implications of ACE polymorphism in patients with left ventricular hypertrophy. Interactions between ACE and angiotensin II type-1 receptors may have clinical implications for preventing and managing CHD. Screening for genetic risk, as evidenced by certain variants in receptor coding sequence, may prove worthwhile if detrimental effects can be countered by drugs such as ACE inhibitors and angiotensin II receptor blockers. Given the important roles of angiotensin II and bradykinin as modulators of cellular growth and of vasoactivity, deleterious and beneficial effect at different stages of the atherosclerotic process and during acute events leading to myocardial infarction or sudden death can be suspected.
Cambien
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INSERM, Paris, France.
Evans
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D000375:Aging / Q000502:physiology; D015906:Angioplasty, Balloon, Coronary; D001808:Blood Vessels / Q000473:pathology; D006332:Cardiomegaly / Q000209:etiology; D003327:Coronary Disease / Q000235:genetics* / Q000401:mortality / Q000628:therapy; D003920:Diabetes Mellitus / Q000235:genetics; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D006984:Hypertrophy; D007703:Peptidyl-Dipeptidase A / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic; D012008:Recurrence
D007703:Peptidyl-Dipeptidase A