title: Neutrophil adhesion molecule expression and response to stimulation with bacterial wall products in humans is unaffected by parenteral nutrition.
abstract: 1. Total parenteral nutrition is associated with a high incidence of septic complications. This may be partly due to neutrophil dysfunction induced by the parenteral nutrition. 2. Neutrophil adhesion molecule expression and the expression of CD11b in response to stimulation with formylmethionyl-leucyl-phenylalanine and lipopolysaccharide were determined before and after 24 h of lipid-containing parenteral nutrition. Eighteen adult patients referred for parenteral nutrition were studied. 3. There was no change in the expression of neutrophil L-selectin (CD62L), CD11a, CD11b, CD11c or CD15. Neutrophil response to stimulation with formylmethionyl-leucyl-phenylalanine and lipopolysaccharide as determined by CD11b expression was unaffected by parenteral nutrition. 4. This study has shown no evidence of parenteral nutrition-induced neutrophil dysfunction.
authors.affiliation: University Department of Surgery, St James's University Hospital, Leeds, U.K.
authors.forename: S M
authors.initials: SM
authors.lastname: Plusa
authors.forename: N
authors.initials: N
authors.lastname: Webster
authors.forename: J N
authors.initials: JN
authors.lastname: Primrose
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016167:Integrin alphaXbeta2 / Q000378:metabolism; D019041:L-Selectin / Q000378:metabolism; D016256:Lewis X Antigen / Q000378:metabolism; D008055:Lipids / Q000008:administration & dosage*; D008070:Lipopolysaccharides / Q000494:pharmacology; D016169:Lymphocyte Function-Associated Antigen-1 / Q000378:metabolism; D016177:Macrophage-1 Antigen / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D010289:Parenteral Nutrition, Total; D018805:Sepsis / Q000378:metabolism*; D013268:Stimulation, Chemical
chemical_list: D015815:Cell Adhesion Molecules; D016167:Integrin alphaXbeta2; D016256:Lewis X Antigen; D008055:Lipids; D008070:Lipopolysaccharides; D016169:Lymphocyte Function-Associated Antigen-1; D016177:Macrophage-1 Antigen; D019041:L-Selectin; D009240:N-Formylmethionine Leucyl-Phenylalanine