title: Membranous nephropathy complicating adenolymphoma of the parotid (Warthin's tumour).
abstract: Membranous nephropathy has been described in association with many malignancies including various lymphomas. However, it has not been previously described as a complication of benign solid adenolymphoma of the parotid, also called Warthin's tumour. We describe a patient who presented with an adenolymphoma of the parotid, and developed a severe nephrotic syndrome due to membranous nephropathy 6 months after the parotid swelling. The nephrotic syndrome resolved following parotidectomy and a short course of immunosuppression with prednisolone and cyclophosphamide. The possible pathophysiologic mechanisms are discussed.
authors.affiliation: Department of Renal Medicine and Transplantation and Histopathology, London Hospital Medical College, UK.
authors.forename: S P
authors.initials: SP
authors.lastname: Kon
authors.forename: S L
authors.initials: SL
authors.lastname: Fan
authors.forename: J T
authors.initials: JT
authors.lastname: Kwan
authors.forename: S M
authors.initials: SM
authors.lastname: Dodd
authors.forename: M J
authors.initials: MJ
authors.lastname: Raftery
mesh_terms: D000235:Adenolymphoma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000009:adverse effects / Q000627:therapeutic use; D015433:Glomerulonephritis, Membranous / Q000097:blood / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D011239:Prednisolone / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D018906:Antineoplastic Agents, Alkylating; D018931:Antineoplastic Agents, Hormonal; D003520:Cyclophosphamide; D011239:Prednisolone