Estimation of steady state antibiotic concentration in cerebrospinal fluid from single-dose kinetics.
OBJECTIVE
Assuming linear kinetics, the mean CSF concentrations of an antibacterial in steady state (CssCSF) can be estimated, when the area under the concentration-time curve in CSF after the first dose is known. For this purpose we propose the function CssCSF = AUCCSF.Anticipated dose/Dosing Interval. Applied dose.


RESULTS
Together with the MIC and MBC of the causative pathogen, the estimate is of value in the choice of antibacterial drug and the dosing regimen in central nervous system infections.
Nau
R
R
Department of Neurology, University of Göttingen, Germany.
Prange
H W
HW
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001812:Blood-Brain Barrier; D002493:Central Nervous System Diseases / Q000188:drug therapy*; D003141:Communicable Diseases / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007700:Kinetics; D012189:Retrospective Studies
D000900:Anti-Bacterial Agents