Efficacy and toxicity of radiation in preparative regimens for pediatric stem cell transplantation. II: Deleterious consequences.
There has been a dramatic improvement in the treatment of both allogeneic and autologous stem cell transplants, especially in children and young adults. However, attempts to apply more intensive conditioning treatments to the more refractory pediatric malignancies have also increased the risks of deleterious consequences. This review examines the risks, and reports important variations in the toxic effects of using different conditioning techniques.
Miale
T D
TD
Department of Pediatrics, University of Tennessee Medical Center at Knoxville, USA.
Sirithorn
S
S
Ahmed
S
S
D002648:Child; D006086:Graft vs Host Disease / Q000453:epidemiology / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation; D006504:Hepatic Veno-Occlusive Disease / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D017564:Radiation Pneumonitis / Q000453:epidemiology; D012307:Risk Factors; D019172:Transplantation Conditioning / Q000009:adverse effects*; D016896:Treatment Outcome; D014916:Whole-Body Irradiation / Q000009:adverse effects*