Structure and in vivo activity of hypoglycaemic analogues of human growth hormone (6-13).
A range of peptide analogues related to Asu11-human growth hormone (6-13) have been synthesized and tested for hypoglycaemic activity using in vivo insulin tolerance tests. Utilising an alanine scan procedure and a selective amino acid residue approach these structure-activity studies suggest that residues Phe10, Arg8 and the C-terminal beta-turn structure are important for the expression of biological activity.
Thompson
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Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.
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Rae
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Hearn
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D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D019382:Human Growth Hormone / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D010446:Peptide Fragments; D019382:Human Growth Hormone