title: Immunohistochemical analysis of c-Fos and c-Jun in retinoblastoma.
abstract: The c-fos promoter is negatively regulated by the retinoblastoma (Rb)-susceptibility-gene-encoded protein as well as by other genes involved in the control of transcription, cell cycle regulation and neoplastic transformation. We have examined by immunohistochemistry the c-Fos and c-Jun proteins in five cases of retinoblastoma in order to evaluate eventual alterations in their expression in vivo, possibly related to a gene mutation or to loss of Rb negative control.
authors.affiliation: Istituto di Clinica Oculistica, Università degli Studi di Firenze, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Faraldi
authors.forename: A
authors.initials: A
authors.lastname: Calzolari
authors.forename: M
authors.initials: M
authors.lastname: Forni
authors.forename: F
authors.initials: F
authors.lastname: Chiarelli
authors.forename: F
authors.initials: F
authors.lastname: Mincione
authors.forename: G
authors.initials: G
authors.lastname: Alfieri
mesh_terms: D000818:Animals; D006801:Humans; D007124:Immunoenzyme Techniques; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism*; D011817:Rabbits; D012175:Retinoblastoma / Q000378:metabolism* / Q000473:pathology
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun