Effects of tetramethylpyrazine phosphate and sodium ferulate alone or in combination on hemodynamics in anesthetized dog.
Hemodynamic actions of intravenous (iv) administration of tetramethylpyrazine phosphate (TMPP) and sodium ferulate (SF) alone or in combination were studied in anesthetized dogs. When given alone, TMPP increased left ventricular systolic pressure (LVSP), peak positive first derivative of left ventricular pressure (+LVdp/dt), coronary blood flow (CBF) and heart rate (HR) while decreasing mean aortic pressure (mAoP). SF alone did not produce any significant hemodynamic changes. When the two were administered in combination, SF antagonized dose-dependently the hemodynamic actions of TMPP. Results of this study did not support the efficacy of combined treatment of Ligusticum wallichi and Angelica root, which contain TMPP and SF respectively.
Huang
X
X
Department of Traditional Chinese Medicine, Xifing Hospital, Fourth Military Medical University, Xi'an, China.
Zang
Y
Y
Wang
Y
Y
Niu
G
G
Wen
A
A
Ren
P
P
D000704:Analysis of Variance; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D003373:Coumaric Acids / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007262:Infusions, Intravenous / Q000662:veterinary; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D011719:Pyrazines / Q000008:administration & dosage / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*
D000959:Antihypertensive Agents; D003373:Coumaric Acids; D010936:Plant Extracts; D011719:Pyrazines; D014665:Vasodilator Agents; C004999:ferulic acid; C017953:tetramethylpyrazine