Intraoperative mitomycin-C versus postoperative topical mitomycin-C drops for the treatment of pterygium.
OBJECTIVE
To evaluate the safety and efficacy of two different regimens of mitomycin-C (MMC) application as adjunctive chemotherapy in the treatment of pterygia.


METHODS
One hundred fifty-six patients underwent pterygium excision using the bare sclera technique. They were randomly assigned to have either 0.1 mg/ml of MMC applied to the bare sclera for 3 minutes intraoperatively, or 0.05-mg/ml drops applied topically for 2 weeks postoperatively. The mean follow-up period was 11 months (range 7 to 17).


RESULTS
Complications with the intraoperative MMC included 5 cases of recurrence (5.75%), 2 cases of superficial punctate keratitis (SPK), and 3 cases of delayed conjunctival wound healing. Topical MMC led to 6 cases of recurrence (6.9%), 5 cases of SPK, 4 cases of delayed conjunctival wound healing, and 2 cases of mild iritis.


CONCLUSIONS
A single, intraoperative application of MMC is a simple, effective alternative adjunctive treatment for pterygium.
Helal
M
M
Department of Ophthalmology, El-Maghraby Eye Center, Jeddah, Saudi Arabia.
Messiha
N
N
Amayem
A
A
el-Maghraby
A
A
Elsherif
Z
Z
Dabees
M
M
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D009883:Ophthalmic Solutions; D011184:Postoperative Period; D011625:Pterygium / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery*; D012008:Recurrence; D012189:Retrospective Studies; D014945:Wound Healing / Q000187:drug effects
D000903:Antibiotics, Antineoplastic; D009883:Ophthalmic Solutions; D016685:Mitomycin