title: Kinetics of anti-mannan antibodies useful in confirming invasive candidiasis in immunocompromised patients.
abstract: In studying the anti-mannan antibodies longitudinally in serial serum samples of three immunocompromised patients, it was observed that anti-mannan antibodies started to increase shortly after the moment that cultures of deep-tissue sites became positive with Candida albicans. The mean anti-mannan antibody titers determined in a group of 36 immunocompromised patients with invasive candidiasis increased within two weeks after the probable onset of invasive candidiasis. In contrast, anti-mannan antibody levels in serial serum samples of 14 immunocompromised patients who were only colonized with C. albicans remained stable or decreased over time. The HA test measuring the anti-mannan antibodies was 64% sensitive and 89% specific in determining invasive candidiasis. In contrast, antibodies specific for candidal cytoplasmic antigens or enolase alone were of little value in confirming invasive candidiasis in these immunocompromised patients.
authors.affiliation: Department of Clinical Microbiology and Antimicrobial Therapy, Erasmus University School of Medicine, Rotterdam, Netherlands.
authors.forename: A J
authors.initials: AJ
authors.lastname: van Deventer
authors.forename: W H
authors.initials: WH
authors.lastname: Goessens
authors.forename: J H
authors.initials: JH
authors.lastname: van Zeijl
authors.forename: J W
authors.initials: JW
authors.lastname: Mouton
authors.forename: M F
authors.initials: MF
authors.lastname: Michel
authors.forename: H A
authors.initials: HA
authors.lastname: Verbrugh
mesh_terms: D000293:Adolescent; D000328:Adult; D000908:Antibodies, Fungal / Q000097:blood / Q000276:immunology*; D000946:Antigens, Fungal / Q000097:blood / Q000276:immunology*; D002176:Candida albicans / Q000276:immunology* / Q000302:isolation & purification; D002177:Candidiasis / Q000097:blood / Q000188:drug therapy / Q000276:immunology* / Q000382:microbiology; D003378:Counterimmunoelectrophoresis; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016867:Immunocompromised Host / Q000276:immunology*; D007700:Kinetics; D008297:Male; D008351:Mannans / Q000032:analysis / Q000276:immunology*; D011933:Reagent Kits, Diagnostic
chemical_list: D000908:Antibodies, Fungal; D000946:Antigens, Fungal; D008351:Mannans; D011933:Reagent Kits, Diagnostic