title: Investigation of the reproductive and growth hormone status of dogs affected by idiopathic recurrent flank alopecia.
abstract: The reproductive and growth hormone status of a group of 12 neutered dogs affected by idiopathic recurrent flank alopecia was investigated at both maximum and minimum photoperiod using the adrenocorticotrophic hormone (ACTH) stimulation test, the xylazine stimulation test and the insulin-like growth factor I (IGF-I) assay. When compared with a group of nine neutered control dogs, the plasma reproductive hormone concentrations were not significantly different with one exception; a significantly greater post-ACTH plasma progesterone concentration was detected in the affected group at minimum photoperiod (P < 0.05). The significance of this finding in isolation is unclear. Growth hormone response to intravenous xylazine was assessed in the affected group at maximum photoperiod only and was found to be within normal limits in eight of the dogs. Serum IGF-I concentrations were significantly greater in the affected group at maximum photoperiod but the groups were not significantly different at minimum photoperiod. These results suggest that dogs with idiopathic recurrent flank alopecia are of normal reproductive and growth hormone status.
authors.affiliation: Department of Small Animal Medicine and Surgery, Royal Veterinary College, Hatfield, Hertfordshire.
authors.forename: C F
authors.initials: CF
authors.lastname: Curtis
authors.forename: H
authors.initials: H
authors.lastname: Evans
authors.forename: D H
authors.initials: DH
authors.lastname: Lloyd
mesh_terms: D019326:17-alpha-Hydroxyprogesterone / Q000097:blood; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000505:Alopecia / Q000097:blood / Q000662:veterinary*; D000735:Androstenedione / Q000097:blood; D000818:Animals; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D004958:Estradiol / Q000097:blood*; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006854:Hydrocortisone / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008297:Male; D017440:Photoperiod; D011374:Progesterone / Q000097:blood*; D013739:Testosterone / Q000097:blood*; D014991:Xylazine / Q000494:pharmacology
chemical_list: D014991:Xylazine; D013739:Testosterone; D000735:Androstenedione; D011374:Progesterone; D004958:Estradiol; D007334:Insulin-Like Growth Factor I; D019326:17-alpha-Hydroxyprogesterone; D000324:Adrenocorticotropic Hormone; D013006:Growth Hormone; D006854:Hydrocortisone