Nitric oxide synthase is concentrated at the skeletal muscle endplate.
NO performs a wide array of cell signaling functions. Neuronal NO synthase (nNOS) immunoreactivity and nicotinamide adenine dinucleotide phosphate diaphorase (NDP) activity, a marker of nNOS, were concentrated at adult rat neuromuscular junctions and persisted in denervated muscle indicating the localization of the enzyme to the postsynaptic surface. The concentration of nNOS at the muscle endplate suggests NO could serve as a messenger pre- and postsynapticly.
Kusner
L L
LL
Department of Neurology, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Department of Veterans Affairs Medical Center, OH 44106, USA.
Kaminski
H J
HJ
D000818:Animals; D007150:Immunohistochemistry; D009045:Motor Endplate / Q000201:enzymology*; D009121:Muscle Denervation; D018482:Muscle, Skeletal / Q000294:innervation*; D009252:NADPH Dehydrogenase / Q000378:metabolism; D009469:Neuromuscular Junction / Q000201:enzymology; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D009994:Osmolar Concentration; D051381:Rats; D011917:Rats, Inbred Lew; D012584:Sciatic Nerve; D013569:Synapses / Q000201:enzymology; D014018:Tissue Distribution
D019001:Nitric Oxide Synthase; D009252:NADPH Dehydrogenase