title: The effect of peritonitis on the peritoneal membrane transport properties in patients on CAPD.
abstract: Peritonitis is known to acutely affect the transport characteristics of the peritoneal membrane, however, the long-term effects are not known. We studied the effect of peritoneal inflammation on mean dialysate-to-plasma creatinine concentration ratio (D/P), dialysate protein losses (DPL, g/week), and dialysate albumin losses (DAL, g/week), done at six weeks or more postepisode, in 152 patients [102 (67%) males, mean age 57 years (range 21-91)]. These patients were on continuous ambulatory peritoneal dialysis for a mean of twelve months (range 1-97). A total of 94 distinct peritonitis episodes were managed in 47 patients (31%). The number of patients with 0, 1, 2, 3, 4, and 5 episodes of peritonitis were 105, 29, 3, 6, 4, and 5. These episodes were treated with a standard protocol. There were no statistically significant differences between the D/P, DPL, or DAL between the groups. The parameters did not show any correlation to time on dialysis. Thus, in conclusion, peritonitis, if promptly treated, does not cause any permanent change in D/P, DAL, or DPL.
authors.affiliation: Division of Nephrology, University of Missouri-Columbia, USA.
authors.forename: S
authors.initials: S
authors.lastname: Goel
authors.forename: P
authors.initials: P
authors.lastname: Kathuria
authors.forename: H L
authors.initials: HL
authors.lastname: Moore
authors.forename: B F
authors.initials: BF
authors.lastname: Prowant
authors.forename: K D
authors.initials: KD
authors.lastname: Nolph
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001798:Blood Proteins / Q000378:metabolism*; D002463:Cell Membrane Permeability / Q000502:physiology*; D003404:Creatinine / Q000097:blood*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010538:Peritonitis / Q000503:physiopathology*; D012709:Serum Albumin / Q000378:metabolism*
chemical_list: D001798:Blood Proteins; D012709:Serum Albumin; D003404:Creatinine