Effects of Fuller's Earth and activated charcoal on oral absorption of paraquat in rabbits.
1. Thirty male rabbits of local strain (weighing 1.5-2 kg) were divided into five groups. Four groups were treated with an oral dose of paraquat, which was followed by either Fuller's Earth or activated charcoal 0.5 or 2.0 h later. The remaining group acted as the control group and was treated only with an oral dose of paraquat. The dose of paraquat was 20.0 mg/kg given in a concentration of 20.0 mg/mL. 2. Both adsorbents were administered in 15 mL normal saline as a 30% slurry. Blood was sampled from the ear vein 0.5, 1, 2, 4, 8 and 24h after the administration of paraquat. 3. Paraquat concentration was determined spectophotometrically at 600 nm by comparing against a standard curve of paraquat obtained by the addition of standard paraquat into normal rabbit serum and extracting interfering substances with ether. 4. The results of the present study show that either adsorbent can bring down the serum paraquat level. There was no significant difference found in the effectiveness of either adsorbent. 5. It is concluded that the administration of an adsorbent as early as possible will help in the reduction of paraquat absorption from the gastrointestinal tract. 6. Activated charcoal is still effective in lowering serum paraquat concentration when given more than 1 h after ingestion of paraquat.
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Pharmacology Department, Faculty of Medicine, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Lee
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D000327:Adsorption; D017607:Aluminum Compounds / Q000627:therapeutic use*; D000704:Analysis of Variance; D000818:Animals; D002606:Charcoal / Q000627:therapeutic use*; D006540:Herbicides / Q000097:blood / Q000506:poisoning*; D017616:Magnesium Compounds / Q000627:therapeutic use*; D008297:Male; D010269:Paraquat / Q000097:blood / Q000506:poisoning*; D011817:Rabbits; D017640:Silicates / Q000627:therapeutic use*; D013053:Spectrophotometry
D017607:Aluminum Compounds; D006540:Herbicides; D017616:Magnesium Compounds; D017640:Silicates; D002606:Charcoal; C001262:Fuller's Earth; D010269:Paraquat