Electrical conductivity dispersion as a probe of membrane modifications in mouse polyomavirus infected cells in culture.
In this report we investigate the inhibition of membrane conductivity, due to the murine polyomavirus infection in permissive cells in culture. We define experimental conditions to have reproducible results and demonstrate that the intensity of the effects on the cell membrane, depends upon the virus titer used in the infection. Finally, the virus dependent effects disappear if the infection is performed in the presence of a drug that inhibits polymavirus DNA replication.
Bonincontro
A
A
Dipartimento di Fisica, Universita di Roma "La Sapienza", Roma, Italy.
Iacoangeli
A
A
Risuleo
G
G
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D055592:Biophysical Phenomena; D001703:Biophysics; D002460:Cell Line; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism*; D004261:DNA Replication / Q000187:drug effects; D004553:Electric Conductivity; D007476:Ionophores / Q000494:pharmacology; D051379:Mice; D008985:Monensin / Q000494:pharmacology; D011120:Polyomavirus / Q000187:drug effects / Q000378:metabolism / Q000472:pathogenicity*; D027601:Polyomavirus Infections / Q000378:metabolism; D014412:Tumor Virus Infections / Q000378:metabolism
D000998:Antiviral Agents; D007476:Ionophores; D008985:Monensin