title: Dapiprazole for patients with night haloes after excimer keratectomy.
abstract: BACKGROUND
  Haloes causing difficulties during the night driving are one of the common complications of photorefractive keratectomy (PRK). The presumed reason for this phenomenon is the different refraction of light through the treated and untreated areas of the cornea. Its magnitude is proportional to the ratio between the treated area and pupil size. At nighttime, when the pupil dilates, rays from treated and untreated areas of the cornea reach the retina at different foci and produce haloes. We investigated whether dapiprazole, a miotic alpha-blocker drug, would be helpful in reducing night haloes in patients after PRK.
  
  
  METHODS
  Twenty-four patients who complained of night haloes after PRK participated in our study. All were given dapiprazole 0.5% before night driving. Change in pupil size was recorded, and all patients completed a questionnaire on changes in the severity of haloes after instillation of dapiprazole.
  
  
  RESULTS
  Improvement was described as very significant in five patients, moderate in ten and slight in seven. There was no improvement in two patients. The only side effect was slight irritation, which resolved within 1 h.
  
  
  CONCLUSIONS
  Our results demonstrate that dapiprazole improves the subjective discomfort caused by night haloes in post-PRK patients.
authors.affiliation: Department of Ophthalmology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Alster
authors.forename: A
authors.initials: A
authors.lastname: Loewenstein
authors.forename: T
authors.initials: T
authors.lastname: Baumwald
authors.forename: I
authors.initials: I
authors.lastname: Lipshits
authors.forename: M
authors.initials: M
authors.lastname: Lazar
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000328:Adult; D001334:Automobile Driving; D005260:Female; D019466:Glare; D006801:Humans; D054018:Lasers, Excimer; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D018903:Photorefractive Keratectomy / Q000009:adverse effects*; D010865:Pilot Projects; D010879:Piperazines; D011680:Pupil / Q000187:drug effects; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*; D014786:Vision Disorders / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000317:Adrenergic alpha-Antagonists; D009883:Ophthalmic Solutions; D010879:Piperazines; D014230:Triazoles; C035289:dapiprazole