title: Investigation of the effect of tetrahydroaminoacridine on turnover kinetics of camel (Camelus dromedarius) retina acetylcholinesterase.
abstract: The effect of tetrahydroaminoacridine (THA) on turnover kinetics of camel retina acetylcholinesterase has been investigated. The turnover number (Kcat) and specificity constant (Ksp) were 62.1 min-1 and 9.92 x 10(5) (M. min)-1 in the control system while the values for both parameters were lowered by 25-68% and 48-87% in the THA (0.05-0.4 microM) treated systems respectively. Therefore, THA's effect on turnover number must be considered at the time of therapy to the Alzheimer's disease patients.
authors.affiliation: Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
authors.forename: A A
authors.initials: AA
authors.lastname: al-Jafari
authors.forename: M A
authors.initials: MA
authors.lastname: Kamal
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000122:Acetylthiocholine / Q000378:metabolism; D000818:Animals; D002162:Camelus; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D002945:Cisplatin / Q000494:pharmacology; D003520:Cyclophosphamide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007700:Kinetics; D008727:Methotrexate / Q000494:pharmacology; D012160:Retina / Q000187:drug effects / Q000201:enzymology*; D012995:Solubility; D013619:Tacrine / Q000494:pharmacology*; D013860:Thiocholine / Q000031:analogs & derivatives / Q000378:metabolism
chemical_list: D002800:Cholinesterase Inhibitors; D000122:Acetylthiocholine; D013619:Tacrine; D013860:Thiocholine; C027395:acetyl-beta-(methylthio)choline; D003520:Cyclophosphamide; D000110:Acetylcholinesterase; D002945:Cisplatin; D008727:Methotrexate