Immunocytochemical studies of cell differentiation during rat salivary gland development.
The development of the rat submandibular and parotid glands has been studied using antibodies to secretory proteins as cell-specific markers. Although the morphology of the glands and the timing of the main steps of cytodifferentiation are substantially different, they have several proteins and developmental features in common. The latter include the initial formation of perinatal acini which undergo a transition to adult acini expressing a different complement of secretory proteins; the development of adult intercalated ducts (ID) from the perinatal acinar cells; and the retention of the perinatal phenotype in some cells of the ID.
Hand
A R
AR
Department of Pediatric Dentistry, University of Connecticut Health Center, Farmington 06030, USA. hand@nso1.uchc.edu
Sivakumar
S
S
Barta
I
I
Ball
W D
WD
Mirels
L
L
D000818:Animals; D015415:Biomarkers; D002454:Cell Differentiation / Q000502:physiology; D007150:Immunohistochemistry; D010306:Parotid Gland / Q000737:chemistry / Q000166:cytology* / Q000196:embryology*; D013363:Submandibular Gland / Q000737:chemistry / Q000166:cytology* / Q000196:embryology*
D015415:Biomarkers