Prediction of the three-dimensional structure of human interleukin-7 by homology modeling.
The three-dimensional structure of human interleukin (IL)-7 has been predicted based on homology to human IL-2, IL-4, granulocyte-macrophage colony stimulating factor and growth hormone. The model has a topology common to other cytokines and displays a unique disulfide pattern. Knowledge of the tertiary structure of IL-7 has implications for analysis of key binding regions, suggestions for mutagenesis experiments and design of (ant)agonists. In this context, the model is discussed and compared with other cytokine structures.
Kroemer
R T
RT
Physical and Theoretical Chemistry Laboratory, University of Oxford, UK.
Doughty
S W
SW
Robinson
A J
AJ
Richards
W G
WG
D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D003198:Computer Simulation; D003553:Cystine / Q000032:analysis; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000737:chemistry; D013006:Growth Hormone / Q000737:chemistry; D006801:Humans; D007376:Interleukin-2 / Q000737:chemistry; D015847:Interleukin-4 / Q000737:chemistry; D015851:Interleukin-7 / Q000737:chemistry*; D051379:Mice; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D013045:Species Specificity
D007376:Interleukin-2; D015851:Interleukin-7; D015847:Interleukin-4; D003553:Cystine; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D013006:Growth Hormone