Synthesis, characterization, and antitumor activity of a series of novel cisplatin analogs with cis-1,4-diaminocyclohexane as nonleaving amine group.
A series of novel platinum(II) complexes of the type PtII(cis-1,4-DACH)X (where cis-1,4-DACH = cis-1,4-diaminocyclohexane and X = dichloro, sulfato, oxalato, malonato, methylmalonato, tartronato, or 1,1-cyclobutanedicarboxylato [CBDCA) ligand and novel platinum(IV) complexes of the types PtIV(cis-1,4-DACH)trans(Y)2Cl2 (where Y = chloro, hydroxo, acetato, propionato, or butyrato ligand) and PtIV(cis-1,4-DACH)trans(Cl)2(X) (where X = oxalato or CBDCA ligand) were synthesized and characterized by elemental analysis, infrared, and 195Pt NMR spectroscopic techniques. Platinum complexes had good in vitro cytotoxic activity against murine leukemia L1210/0 (IC50 = 0.0032-1.60 microM) and human ovarian A2780 (IC50 = 0.045-0.430 microM) cell lines.
Shamsuddin
S
S
Department of Clinical Investigation, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
Takahashi
I
I
Siddik
Z H
ZH
Khokhar
A R
AR
D000588:Amines / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002945:Cisplatin / Q000737:chemistry*; D007939:Leukemia L1210; D051379:Mice; D017671:Platinum Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000588:Amines; D000970:Antineoplastic Agents; D017671:Platinum Compounds; D002945:Cisplatin