Contrast enhancement of PC-3 prostate cancer for magnetic resonance imaging: animal studies using tumor-localizing Mn-metalloporphyrin (THF-Mn-Asp).
OBJECTIVE
The objective of the present study was to test, in nude mouse PC-3 tumors, the contrast enhancement of 2,4-bis(1-tetrahydro-fulfuroxyethyl)-deuteroporphynyl(IX)-6- 7-bisaspartic acid (THF-Mn-ASP), which is a hematoporphyrin derivative and depresses T1 relaxation time on magnetic resonance (MR) imaging.


METHODS
THF-Mn-ASP or gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) was intravenously administered, and MR imaging of the tumors transplanted into nude mice was performed on T1-weighted images.


RESULTS
After administration of THF-Mn-Asp, the signal intensity of PC-3 tumors increased and the tumor/muscle intensity ratio was highest at about 1 hour. The tumor/muscle intensity ratio, in contrast, was highest at about 5 minutes after administration of Gd-DTPA. The increase in intensity ratio was 32% in THF-Mn-ASP and 28% in Gd-DTPA.


CONCLUSIONS
The preliminary study suggested that THF-Mn-Asp has a predilection to accumulate in PC-3 tumors, and it seems to provide good contrast enhancement with tumor specificity for MR imaging.
Suzuki
T
T
Department of Urology, Gunma University School of Medicine, Japan.
Nakano
K
K
Tomiyoshi
K
K
Sakata
I
I
Endo
K
K
Yamanaka
H
H
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives*; D003287:Contrast Media; D003905:Deuteroporphyrins; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives*; D011471:Prostatic Neoplasms / Q000473:pathology*
C101924:2,4-bis(1-tetrahydro-fulfuroxyethyl)-deuteroporphynyl(IX)-6-7-bisaspartic acid; D003287:Contrast Media; D003905:Deuteroporphyrins; D009942:Organometallic Compounds; D001224:Aspartic Acid; D004369:Pentetic Acid; D019786:Gadolinium DTPA