Ameloblastoma in a female Wistar rat.
A spontaneous ameloblastoma of the right mandible is described in a 120-week-old female Wistar rat (strain Chbb: THOM). The tumour had a locally aggressive growth pattern and was histologically characterized by sheets and islands of odontogenic epithelium bounded by a palisaded layer of ameloblast-like cells. Because of multifocal keratinizing squamous metaplasia of the stellate reticulum tissue, the tumour was classified as an acanthomatous ameloblastoma. Cyst formation, areas of stromal hyalinization and enamel matrix-like inclusions were further characteristics of the neoplasm. The epithelial elements stained strongly positive for broad spectrum cytokeratins.
Ernst
H
H
Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, Germany.
Mirea
D
D
D000564:Ameloblastoma / Q000473:pathology*; D000818:Animals; D005260:Female; D008339:Mandibular Neoplasms / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar