The protective effect of Alstonia scholaris R. Br. on hepatotoxin-induced acute liver damage.
The hepatoprotective effect of Alstonia scholaris R. Br. on liver injuries induced by carbon tetrachloride (CCl4). beta-D-galactosamine, acetaminophen and ethanol were investigated by means of serum-biochemical and histopathological examinations. Post treatment of A scholaris reduced dose-dependently the elevation of serum transaminases level and histopathological changes such as cell necrosis, inflammatory cell infiltration, which were caused by the single administration of 32 microliters/kg CCl4 or 600 mg/kg acetaminophen in mice. A. scholaris significantly lowered 288 mg/kg beta-D-galactosamine induced serum transaminases elevation in the serum-biochemical analysis in rats. A tendency was also shown to inhibit cell necrosis and inflammatory cell infiltration caused by beta-D-galactosamine in histopathological examination. All serological and histopathological effects of A. scholaris were compared with those of Bupleurum chinense, which has been reported previously as a treatment criteria of hepatitis.
Lin
S C
SC
Department of Pharmacology, Taipei Medical College, Taiwan.
Lin
C C
CC
Lin
Y H
YH
Supriyatna
S
S
Pan
S L
SL
D000082:Acetaminophen / Q000008:administration & dosage / Q000633:toxicity; D000410:Alanine Transaminase / Q000097:blood; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000633:toxicity; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002251:Carbon Tetrachloride / Q000008:administration & dosage / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000633:toxicity; D005688:Galactosamine / Q000008:administration & dosage / Q000633:toxicity; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects* / Q000293:injuries / Q000473:pathology; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D000637:Transaminases / Q000097:blood
D018712:Analgesics, Non-Narcotic; D010936:Plant Extracts; D000082:Acetaminophen; D000431:Ethanol; D005688:Galactosamine; D002251:Carbon Tetrachloride; D000637:Transaminases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase