[Regulation of muscarinic potassium channels].
Inwardly rectifying muscarinic potassium channels are directly activated by M2 muscarinic receptors in heart via a Pertussis toxin-sensitive G-protein. An intracellular second messenger is not involved in their activation. These channels undergo rapid (in about 30 seconds) and short-term desensitization. This desensitization is reversible in about 5 minutes. The molecular events underlying muscarinic potassium channels desensitization are still under study and apparently involve a phosphorylation/dephosphorylation process of one the proteins, i.e. the receptor, the G-protein or the channel itself.
Thiebot
H
H
Laboratoire de Physiologie Cellulaire et Moléculaire, Université de Caen.
Duchatelle-Gourdon
I
I
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D019204:GTP-Binding Proteins / Q000187:drug effects / Q000378:metabolism; D009116:Muscarine / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D037342:Pertussis Toxin; D015221:Potassium Channels / Q000378:metabolism*; D010566:Virulence Factors, Bordetella / Q000494:pharmacology
D015221:Potassium Channels; D010566:Virulence Factors, Bordetella; D009116:Muscarine; D037342:Pertussis Toxin; D019204:GTP-Binding Proteins; D000109:Acetylcholine