Cytotoxic cardenolides from woods of Euonymus alata.
Three cytotoxic cardenolides, acovenosigenin A 3-O-alpha-L-ramnopyranoside (1), euonymoside A (2) and euonymusoside A (3), were isolated from the woods of Euonymus alata (Celastraceae). The chemical structure of a new cardenolide, euonymusoside A (3) has been elucidated on the basis of extensive spectral analysis and enzymic hydrolysis to be acovenosigenin A (1 beta, 3 beta, 14 beta-trihydroxy-5 beta-cardenolide) 3-O-beta-D-glucopyranosyl (1-->6)-beta-D-glucopyranosyl(1-->4)-alpha-L-rhamnopyranoside. All three showed potent cytotoxic activity against some neoplastic cell lines.
Kitanaka
S
S
College of Pharmacy, Nihon University, Chiba, Japan.
Takido
M
M
Mizoue
K
K
Nakaike
S
S
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002298:Cardenolides / Q000302:isolation & purification* / Q000494:pharmacology; D004073:Digitoxigenin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D002298:Cardenolides; C102253:acovenosigenin A 3-O-ramnopyranoside; C086295:euonymoside A; D004073:Digitoxigenin