title: Computational simulations of mitral regurgitation quantification using the flow convergence method: comparison of hemispheric and hemielliptic formulae.
abstract: Mitral regurgitation results from the incomplete closure of the mitral valve, and the noninvasive diagnosis of this disease remains an important clinical goal. In this study, steady flow computer simulations were used to evaluate flow convergence method for flow rate estimation. The hemispheric and hemielliptic formulae were compared for accuracy in the presence of complicating factors such as ventricular confinement, orifice shape, and aortic outflow. Results showed that in the absence of aortic outflow and ventricular confinement, there was a plateau zone where the hemispheric formula approximated the true flow rate, independent of orifice shape. However, in the presence of complicating factors such as aortic outflow and ventricular confinement, there was no clear zone where the hemispheric formula could be applied. The hemielliptic formula, however, worked in all cases, regardless of chamber size or magnitude of aortic outflow. Therefore, application of the hemielliptic formula should be considered in future clinical studies.
authors.affiliation: Cardiovascular Fluid Mechanics Laboratory, School of Chemical Engineering, Georgia Institute of Technology, Atlanta.
authors.forename: J
authors.initials: J
authors.lastname: Hopmeyer
authors.forename: E
authors.initials: E
authors.lastname: Whitney
authors.forename: D A
authors.initials: DA
authors.lastname: Papp
authors.forename: M S
authors.initials: MS
authors.lastname: Navathe
authors.forename: R A
authors.initials: RA
authors.lastname: Levine
authors.forename: Y H
authors.initials: YH
authors.lastname: Kim
authors.forename: A P
authors.initials: AP
authors.lastname: Yoganathan
mesh_terms: D001013:Aorta, Thoracic / Q000502:physiology; D001783:Blood Flow Velocity; D003198:Computer Simulation; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008944:Mitral Valve Insufficiency / Q000503:physiopathology*; D008955:Models, Cardiovascular; D012039:Regional Blood Flow