Different rifampicin inactivation mechanisms in Nocardia and related taxa.
Mycolic acid-containing bacteria inactivate rifampicin in a variety of ways such as glucosylation, ribosylation, phosphorylation and decolorization. These inactivations were found to be a species-specific phenomena in Nocardia and related taxa. Gordona, Tsukamurella and fast-growing Mycobacterium modified rifampicin by ribosylation of the 23-OH group of the antibiotic. Such ribosylation was not observed in Rhodococcus and Corynebacterium, but phosphorylation of the 21-OH group of rifampicin was observed in one strain of Rhodococcus. Nocardia modified the antibiotic by glucosylation (23-OH group) and phosphorylation, but ribosylation was not observed.
Tanaka
Y
Y
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
Yazawa
K
K
Dabbs
E R
ER
Nishikawa
K
K
Komaki
H
H
Mikami
Y
Y
Miyaji
M
M
Morisaki
N
N
Iwasaki
S
S
D000192:Actinomycetales / Q000187:drug effects* / Q000378:metabolism; D004352:Drug Resistance, Microbial; D006031:Glycosylation; D008826:Microbial Sensitivity Tests; D010766:Phosphorylation; D012293:Rifampin / Q000737:chemistry / Q000494:pharmacology*; D013045:Species Specificity
D012293:Rifampin