title: Differences in basal nocturnal, meal-stimulated, and pentagastrin-stimulated gastric secretion values in a sample of healthy volunteers in basal conditions and under ranitidine influence.
abstract: The gastric secretion values from 16 healthy male volunteers are reported. A nasogastric tube was positioned in the gastric antrum and 10-min gastric secretion samples were obtained hourly by continuous suction. Basal nocturnal, meal-stimulated, and pentagastrin-stimulated gastric acid secretion were measured. Experimental sessions were carried out in control conditions and repeated after a 7-day treatment with placebo and ranitidine (150 mg b.i.d.) in a double-blind procedure. We found six subjects (group I) with basal nocturnal, meal-stimulated, and pentagastrin-stimulated gastric secretion values statistically lower than then rest of the group (group II). Basal nocturnal secretion mean values were 3.99 +/- 6.6 mmol/L (group I) and 59.2 +/- 22.1 mmol/L (group II) (p < 0.01). Meal-stimulated gastric acidity mean values were 33.1 + 17.3 mmol/L (group I) and 65.6 +/- 30.6 mmol/L (group II) (p < 0.05). Pentagastrin-stimulated gastric secretion mean values were 8 +/- 2 mmol/h (group I) and 19.2 +/- 2.7 mmol/h (group II) (p < 0.01). Ranitidine significantly inhibited basal nocturnal, meal-stimulated, and pentagastrin-stimulated gastric acidity values mostly in group II. These results suggest that there are two different patterns of gastric secretion in the healthy male population.
authors.affiliation: Departamento de Investigación Clinica y Biomédica, Hospital General Dr. Miguel Silva, Michoacán, Mexico.
authors.forename: J
authors.initials: J
authors.lastname: Carranza-Madrigal
authors.forename: J E
authors.initials: JE
authors.lastname: Herrera-Abaraca
authors.forename: F
authors.initials: F
authors.lastname: Chavez-Carbajal
authors.forename: Y
authors.initials: Y
authors.lastname: Campos-Perez
authors.forename: L A
authors.initials: LA
authors.lastname: Salazar
mesh_terms: D000328:Adult; D002940:Circadian Rhythm; D004311:Double-Blind Method; D004435:Eating / Q000502:physiology*; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology*; D011899:Ranitidine / Q000494:pharmacology*
chemical_list: D011899:Ranitidine; D010418:Pentagastrin