Eliprodil prevents expression of the 70 kDa heat shock protein in MK801-injured neurones.
The present study examined whether eliprodil (SL 82.0715), an N-methyl-D-aspartate (NMDA) receptor antagonist acting on the polyamine sites induced expression of the 70 kDa heat shock protein (HSP70) in the rat brain. Whereas the NMDA channel blocker MK801 consistently induced HSP70 in posterior cingulate and retrosplenial cortices, eliprodil had no such effects even at the highest dose (50 mg/kg, intraperitoneally), supporting the idea that injury to the cerebrocortical neurones by NMDA receptor antagonists is probably related to specific sites of the receptor. Furthermore, eliprodil, given immediately after injection of MK801, blocked the effects of MK801 on HSP70. The result is discussed in terms of high affinity of eliprodil for the sigma receptor.
Wang
S
S
Institute of Neurobiology, University of Göteborg, Sweden.
Yang
Q
Q
Moller
C J
CJ
Sharp
F R
FR
Haglid
K G
KG
D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects; D016291:Dizocilpine Maleate / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D006360:Heat-Shock Proteins / Q000096:biosynthesis*; D008970:Molecular Weight; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017480:Receptors, sigma / Q000378:metabolism
D018691:Excitatory Amino Acid Antagonists; D006360:Heat-Shock Proteins; D010880:Piperidines; D017480:Receptors, sigma; D016291:Dizocilpine Maleate; C058083:eliprodil