Pharmacokinetics of theophylline in obesity.
Pharmacokinetic analysis of theophylline was performed in 16 obese women before and after 3-week weight-reducing treatment. Decrease of clearance, increase of t1/2, AUC, and MRT were observed. There were no differences between the volume of distribution before and after weight-reducing treatment. Our results suggest that ideal body weight should be used to calculate a loading dose of theophylline for obese patients; weight-reducing treatment may be connected with changes in biotransformation and elimination of theophylline more than with its distribution.
Zahorska-Markiewicz
B
B
Department of Clinical Pharmacology, Silesian University School of Medicine, Katowice, Poland.
Waluga
M
M
Zieliñski
M
M
Klin
M
M
D000328:Adult; D001993:Bronchodilator Agents / Q000493:pharmacokinetics*; D004032:Diet; D005260:Female; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D013806:Theophylline / Q000493:pharmacokinetics*; D015431:Weight Loss / Q000187:drug effects
D001993:Bronchodilator Agents; D013806:Theophylline