title: DNA immunization.
abstract: Inoculation with plasmid DNA vectors encoding immunogenic proteins induces both humoral and cell-mediated immune responses, which often provide protective immunity. Although many questions regarding the mechanism, efficacy and safety of DNA immunization remain to be addressed, this approach may offer a safer and more cost-effective alternative to conventional vaccines.
authors.affiliation: Dept of Neuropharmacology, Scripps Research Insitute, La Jolla, CA 92037, USA.
authors.forename: D E
authors.initials: DE
authors.lastname: Hassett
authors.forename: J L
authors.initials: JL
authors.lastname: Whitton
mesh_terms: D000818:Animals; D003140:Communicable Disease Control / Q000379:methods; D003141:Communicable Diseases / Q000276:immunology; D004333:Drug Administration Routes; D015195:Drug Design; D005822:Genetic Vectors; D007114:Immunization / Q000009:adverse effects / Q000379:methods*; D051379:Mice; D019444:Vaccines, DNA / Q000276:immunology*
chemical_list: D019444:Vaccines, DNA