title: Diagnosis of an anemone cell tumor as a B-cell lymphoma by molecular analysis.
abstract: An 83-year-old man presented with mediastinal and axillary lymphadenopathy. Immunophenotyping and electron microscopy performed on an excision biopsy were inconclusive. On a repeat biopsy a year later the ultrastructural features typical of an anemone cell tumor were seen. A panel of monoclonal antibodies showed positivity for vimentin only. The diagnosis of a high-grade B-cell lymphoma could be made only after detection of immunoglobulin gene rearrangement by polymerase chain reaction gene amplification.
authors.affiliation: Department of Anatomical Pathology, University of Cape Town Medical School, Republic of South Africa.
authors.forename: K
authors.initials: K
authors.lastname: Blakolmer
authors.forename: M F
authors.initials: MF
authors.lastname: Essop
authors.forename: P M
authors.initials: PM
authors.lastname: Close
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000648:ultrastructure; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000235:genetics / Q000648:ultrastructure*; D008297:Male; D016133:Polymerase Chain Reaction