title: Methylphenidate and attentional training. Comparative effects on behavior and neurocognitive performance in twin girls with attention-deficit/hyperactivity disorder.
abstract: The effectiveness of four doses (5-mg, 10-mg, 15-mg, 20-mg) of methylphenidate (MPH) and attentional training (AT) were evaluated using neurocognitive instruments (Continuous Performance Test; Matching Unfamiliar Figures Test), narrow- and broad-band rating scales in the context of a double-blind, placebo-control, within-subject reversal design for dizygotic twin girls with Attention-Deficit/Hyperactivity Disorder (ADHD). Both interventions proved effective for improving neurocognitive test performance and behavior, although broad-band ratings revealed dose-response curves different from those obtained from the neurocognitive tests. Implications for clinical management of girls with ADHD are discussed.
authors.affiliation: Department of Psychology, University of Hawaii, Honolulu 96822, USA. largo@unuhix.uhcc.hawaii.edu
authors.forename: M D
authors.initials: MD
authors.lastname: Rapport
authors.forename: S
authors.initials: S
authors.lastname: Loo
authors.forename: P
authors.initials: P
authors.lastname: Isaacs
authors.forename: S
authors.initials: S
authors.lastname: Goya
authors.forename: C
authors.initials: C
authors.lastname: Denney
authors.forename: S
authors.initials: S
authors.lastname: Scanlan
mesh_terms: D001288:Attention / Q000187:drug effects; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics* / Q000523:psychology / Q000628:therapy; D001521:Behavior Therapy; D000697:Central Nervous System Stimulants / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D004200:Diseases in Twins / Q000235:genetics*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007859:Learning Disabilities / Q000235:genetics* / Q000628:therapy; D008774:Methylphenidate / Q000008:administration & dosage*; D009043:Motor Activity / Q000187:drug effects; D009483:Neuropsychological Tests; D010552:Personality Assessment; D014429:Twins, Dizygotic / Q000235:genetics / Q000523:psychology
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate