Effects of angiotensin II on brain monoamine oxidase activity in non-hypoxic and hypoxic mice.
The effects of angiotensin II (ATII) administered intracerebroventricularly (i.c.v.) at a dose of 0.5 microgram per mouse on the activity of monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) in the forebrain of normoxic and hypoxic mice were studied. The influence of hypoxia (asphyctic and haemic) on MAO-A and MAO-B activity was also investigated. MAO-A activity was increased in haemic hypoxia; MAO-B activity increased in both asphyctic and haemic hypoxia. ATII increased MAO-A activity without affecting MAO-B activity under normoxic conditions. ATII increased MAO-A activity but decreased MAO-B in hypoxic (asphyctic) mice as compared to normoxic controls. The results suggest the role of MAO-A and MAO-B in the ATII-induced increase of susceptibility to acute hypoxia.
Stancheva
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S
Institute of Physiology, Bulgarian Academy of Sciences, Bulgaria.
Georgiev
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V
Alova
L
L
Getova
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D
D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001237:Asphyxia / Q000201:enzymology; D001921:Brain / Q000187:drug effects / Q000201:enzymology* / Q000502:physiology; D000860:Hypoxia / Q000097:blood / Q000201:enzymology*; D007276:Injections, Intraventricular; D007527:Isoenzymes / Q000378:metabolism*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008995:Monoamine Oxidase / Q000378:metabolism*; D016548:Prosencephalon / Q000187:drug effects / Q000201:enzymology
D007527:Isoenzymes; D000804:Angiotensin II; D008995:Monoamine Oxidase