title: Ventilatory effects of eltanolone during induction of anaesthesia: comparison with propofol and thiopentone.
abstract: We recorded the ventilatory effects of eltanolone 0.75 mg kg-1, propofol 2.5 mg kg-1 and thiopentone 4 mg kg-1 at induction of anaesthesia in 76 unpremedicated patients, aged 18-65 yr. Measurements were made using a pneumotachograph incorporated between a close-fitting face mask and a T-piece delivering 35% oxygen. Eltanolone caused significantly less apnoea than propofol (incidence 57% vs 100%) and less reduction in ventilation than propofol (median maximum decrease 4.8 vs 7.8 litre min-1), but the differences between eltanolone and thiopentone were smaller and generally not significant. Ventilatory frequency was maintained well in the eltanolone group.
authors.affiliation: Department of Anaesthetics, Royal Infirmary, Edinburgh.
authors.forename: H J
authors.initials: HJ
authors.lastname: Spens
authors.forename: G B
authors.initials: GB
authors.lastname: Drummond
mesh_terms: D000293:Adolescent; D000328:Adult; D018686:Anesthetics, Intravenous / Q000009:adverse effects / Q000494:pharmacology*; D001049:Apnea / Q000139:chemically induced; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D015742:Propofol / Q000009:adverse effects / Q000494:pharmacology; D012119:Respiration / Q000187:drug effects*; D012131:Respiratory Insufficiency / Q000139:chemically induced; D013256:Steroids / Q000009:adverse effects / Q000494:pharmacology*; D013874:Thiopental / Q000009:adverse effects / Q000494:pharmacology
chemical_list: D018686:Anesthetics, Intravenous; D013256:Steroids; D013874:Thiopental; D015742:Propofol