title: Regression of rubeosis iridis after trabeculectomy combined with mitomycin-C.
abstract: The authors report two cases in which severe rubeosis iridis regressed after trabeculectomy with intraoperative application of mitomycin-C. Several days after the operation, the vessels were no longer perfused. Only white, empty, "ghost" vessels were visible. This phenomenon was observed in one case with well-controlled intraocular pressure (IOP) after surgery, as well as in a case in which IOP rose again to high preoperative values. The authors conclude that the regression of the rubeosis may be caused by a local, intraocular pharmacologic side effect of mitomycin-C, not by the drop in IOP alone.
authors.affiliation: University Eye Clinic, Basel, Switzerland.
authors.forename: A Z
authors.initials: AZ
authors.lastname: Gaspar
authors.forename: J
authors.initials: J
authors.lastname: Flammer
authors.forename: P
authors.initials: P
authors.lastname: Hendrickson
mesh_terms: D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000628:therapy*; D006801:Humans; D007429:Intraocular Pressure; D007432:Intraoperative Period; D007498:Iris / Q000098:blood supply* / Q000503:physiopathology; D008297:Male; D016685:Mitomycin / Q000627:therapeutic use*; D009389:Neovascularization, Pathologic / Q000503:physiopathology / Q000628:therapy*; D014130:Trabeculectomy
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin