title: Assignment of Alzheimer's presenilin-1 (PS-1) gene to 14q24.3 by fluorescence in situ hybridization.
abstract: Presenilin-1 (PS-1) was suggested to be localized on 14q24.3 based on linkage analysis and cDNA cloning. The final identification of PS-1 as the causal gene for Alzheimer's disease (AD) was concluded based on finding of the point mutations in the candidate cDNA linked with pedigrees with early-onset familial AD. We present evidence of its physical genome mapping of PS-1 by fluorescence in situ hybridization method.
authors.affiliation: Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takano
authors.forename: Y
authors.initials: Y
authors.lastname: Yamanouchi
authors.forename: N
authors.initials: N
authors.lastname: Sahara
authors.forename: T
authors.initials: T
authors.lastname: Shirasawa
authors.forename: H
authors.initials: H
authors.lastname: Mori
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D005796:Genes; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008565:Membrane Proteins / Q000235:genetics*; D053764:Presenilin-1
chemical_list: D008565:Membrane Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1