Serum laminin and basic fibroblast growth factor concentrations in patients with complicated Plasmodium falciparum malaria.
Serum concentrations of laminin and basic fibroblast growth factor (FGF) were measured in 20 patients suffering from complicated Plasmodium falciparum malaria in Bangkok. Significant higher mean serum concentrations of laminin were determined prior to treatment (1973 ng/ml) and 7 days after starting medication (1025 ng/ml) in comparison to the control (412 ng/ml). The values remained numerically higher for at least 21 days. With regard to serum basic FGF concentrations, a peak was found 7 day after starting treatment (35.61 pg/ml). In addition, a significant correlation was found for parasite clearance time and basic FGF concentration on day 7 (P < 0.01). These increased values of laminin and basic FGF may be the consequence of endothelial and basement membrane damage induced by sequestration of the parasites. Furthermore, basic FGF might play a role in endothelial repair mechanisms after the clearance of the parasites.
Burgmann
H
H
Department of Infectious Diseases, University of Vienna, Austria.
Looareesuwan
S
S
Viravan
C
C
Vanijanonta
S
S
Zedwitz-Liebenstein
K
K
Vorbach
H
H
Graninger
W
W
D000293:Adolescent; D000328:Adult; D000368:Aged; D000962:Antimalarials / Q000627:therapeutic use*; D037621:Artemisinins; D000077332:Artesunate; D016222:Fibroblast Growth Factor 2 / Q000097:blood*; D006801:Humans; D007700:Kinetics; D007797:Laminin / Q000097:blood*; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology*; D015767:Mefloquine / Q000627:therapeutic use; D008875:Middle Aged; D012717:Sesquiterpenes / Q000627:therapeutic use
D000962:Antimalarials; D037621:Artemisinins; D007797:Laminin; D012717:Sesquiterpenes; D016222:Fibroblast Growth Factor 2; D000077332:Artesunate; C031327:artemisinin; D015767:Mefloquine