title: Tribological and mycological consequences of the use of a miconazole nitrate-containing paste for the prevention of diaper dermatitis: an open pilot study.
abstract: The diaper environment increases the coefficient of skin friction and compromises the function of the stratum corneum. In this study, the tribological and mycological benefit of the use of a miconazole nitrate-containing paste on diapered skin was evaluated. A total of 135 instrumental measurements of both erythema and stratum corneum alterations were made on alternate days for 3 weeks in 15 infants. Biometrological parameters were the chromacity a* of the skin and the squamometry index. Cultures testing for Candida albicans were also performed. In the days following the use of the paste, the chromacity a*, the squamometry index and the number of positive cultures of C. albicans were significantly reduced compared to the same evaluations made off treatment.
  
  
  CONCLUSIONS
  Miconazole nitrate-containing paste reduces the tribological interference between cloth diapers and skin as well as providing the diapered skin with an improved microbial environment.
authors.affiliation: Department of Dermatopathology, CHU du Sart Tilman, Liège, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Piérard-Franchimont
authors.forename: C
authors.initials: C
authors.lastname: Letawe
authors.forename: G E
authors.initials: GE
authors.lastname: Piérard
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D002175:Candida / Q000302:isolation & purification; D003124:Colorimetry; D003963:Diaper Rash / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control*; D004817:Epidermis / Q000473:pathology; D004890:Erythema / Q000473:pathology; D006801:Humans; D007223:Infant; D008825:Miconazole / Q000627:therapeutic use*; D009824:Ointments; D010865:Pilot Projects
chemical_list: D000935:Antifungal Agents; D009824:Ointments; D008825:Miconazole