A novel and basic mechanism of immunosuppression in Chagas' disease: Trypanosoma cruzi releases in vitro and in vivo a protein which induces T cell unresponsiveness through specific interaction with cysteine and glutathione.
Ouaissi
A
A
Research Laboratory on Trypanosomatids, INSERM U 415, Institut Pasteur, Lille, France.
Guevara-Espinoza
A
A
Chabé
F
F
Gomez-Corvera
R
R
Taibi
A
A
D000818:Animals; D002478:Cells, Cultured; D014355:Chagas Disease / Q000276:immunology*; D003545:Cysteine / Q000276:immunology*; D005978:Glutathione / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D015800:Protozoan Proteins / Q000276:immunology*; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology*; D013936:Thymidine / Q000378:metabolism; D014349:Trypanosoma cruzi / Q000276:immunology*
C097550:52-kDa protein, Trypanosoma cruzi; D015800:Protozoan Proteins; D005978:Glutathione; D003545:Cysteine; D013936:Thymidine