Dimethyl sulfoxide/propylene glycol is a suitable solvent for the delivery of diazepam from osmotic minipumps.
The functional integrity of Alzet osmotic minipumps was assessed using two organic solvents (50% (v/v) dimethyl sulfoxide (DMSO)/50% (v/v) propylene glycol (PG) and 100% tetraglycol) which dissolve diazepam, an aqueous insoluble benzodiazepine. Both solvents showed a significant decrease in output rate over time: the decline with tetraglycol was, however, more marked and variable. Further, the DMSO/PG vehicle demonstrated a comparable decline in rate (1.45%) to that of the control vehicles saline and water (1.12%). DMSO/PG is therefore a suitable solvent for the chronic delivery of diazepam from osmotic minipumps.
Arnot
M I
MI
Department of Pharmacology, Faculty of Medicine, University of Alberta, Edmonton, Canada.
Bateson
A N
AN
Martin
I L
IL
D000818:Animals; D003975:Diazepam / Q000008:administration & dosage*; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage*; D015918:Infusion Pumps, Implantable; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000008:administration & dosage*; D051381:Rats; D012997:Solvents
D011409:Propylene Glycols; D012997:Solvents; D019946:Propylene Glycol; D003975:Diazepam; D004121:Dimethyl Sulfoxide