Effects of bromocriptine and/or L-DOPA on neurons in substantia nigra of MPTP-treated C57BL/6 mice.
The effects of bromocriptine and/or L-DOPA on substantia nigra neurons of MPTP-intoxicated mice were investigated. L-DOPA reduced the number of neurons. Bromocriptine protected the neurons from damage by L-DOPA but had no effect on the neurons damaged by MPTP. The treatment of bromocriptine and L-DOPA protected the neurons compared with single administration of bromocriptine. It seems reasonable to suppose that bromocriptine should be added to L-DOPA in order to protect the neurons in parkinsonism.
Fukuda
T
T
Division of Neuropathology, Jikei University School of Medicine, Tokyo, Japan.
Watabe
K
K
Tanaka
J
J
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D002452:Cell Count / Q000187:drug effects*; D007980:Levodopa / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D013378:Substantia Nigra / Q000187:drug effects*
D001971:Bromocriptine; D007980:Levodopa; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine