Hypoxemia associated with cimetidine therapy in a newborn infant.
Cimetidine therapy used for the treatment of gastric bleeding due to tolazoline therapy in a newborn infant was temporally associated with episodes of severe hypoxemia. It appears likely that the histamine H2 receptor blocked by cimetidine obviated the pulmonary vasodilator effect of tolazoline therapy.
Kuint
J
J
Department of Neonatology, The Chaim Sheba Medical Center, Israel.
Linder
N
N
Reichman
B
B
D000317:Adrenergic alpha-Antagonists / Q000009:adverse effects; D000328:Adult; D002927:Cimetidine / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced / Q000188:drug therapy*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000188:drug therapy; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D000860:Hypoxia / Q000139:chemically induced* / Q000188:drug therapy; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008297:Male; D011247:Pregnancy; D014043:Tolazoline / Q000009:adverse effects
D000317:Adrenergic alpha-Antagonists; D006635:Histamine H2 Antagonists; D002927:Cimetidine; D014043:Tolazoline