title: Application of neural networks for the classification of diffuse liver disease by quantitative echography.
abstract: Three different methods were investigated to determine their ability to detect and classify various categories of diffuse liver disease. A statistical method, i.e., discriminant analysis, a supervised neural network called backpropagation and a nonsupervised, self-organizing feature map were examined. The investigation was performed on the basis of a previously selected set of acoustic and image texture parameters. The limited number of patients was successfully extended by generating additional but independent data with identical statistical properties. The generated data were used for training and test sets. The final test was made with the original patient data as a validation set. It is concluded that neural networks are an attractive alternative to traditional statistical techniques when dealing with medical detection and classification tasks. Moreover, the use of generated data for training the networks and the discriminant classifier has been shown to be justified and profitable.
authors.affiliation: Biophysics Laboratory, University Hospital Nijmegen, The Netherlands.
authors.forename: M S
authors.initials: MS
authors.lastname: Gebbinck
authors.forename: J T
authors.initials: JT
authors.lastname: Verhoeven
authors.forename: J M
authors.initials: JM
authors.lastname: Thijssen
authors.forename: T E
authors.initials: TE
authors.lastname: Schouten
mesh_terms: D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000000981:diagnostic imaging*; D008297:Male; D016571:Neural Networks, Computer; D014463:Ultrasonography / Q000379:methods*