Birth characteristics and risk of Wilms' tumour: a nationwide prospective study in Norway.
Relationships between incidence of Wilms' tumour and information recorded at birth were investigated in a prospective study of the 1,489,297 children born in Norway between 1967 and 1992. A total of 119 individuals were diagnosed with Wilms' tumour in the age interval 0-14 years. A high length at birth was significantly associated with a high risk (incidence rate ratio 1.8 for length > or = 53 cm vs < or = 49 cm, 95% CI 1.0-3.2). A low Apgar score at 1 min was also associated with an increased risk (incidence rate ratio 2.2 for Apgar score < or = 8 vs a score > or = 9, 95% CI 1.2-3.9). For all variables for which an association was indicated, the association seemed to be restricted mainly to children aged less than 2 years. This suggests that Wilms' tumour diagnosed early in life may differ aetiologically from that of cases diagnosed later.
Heuch
J M
JM
Section for Medical Informatics and Statistics, University of Bergen, Norway.
Heuch
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D000293:Adolescent; D000367:Age Factors; D001034:Apgar Score; D001724:Birth Weight; D001824:Body Constitution; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007680:Kidney Neoplasms / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D009664:Norway / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D009396:Wilms Tumor / Q000453:epidemiology / Q000209:etiology*