title: Plasma follistatin concentrations increase following lipopolysaccharide administration in sheep.
abstract: 1. The effect of inflammation induced by lipopolysaccharide (LPS) injection on plasma follistatin (FS) concentrations was investigated. 2. Plasma FS and tumour necrosis factor-alpha concentrations increase following LPS administration in ewes. 3. The rise in FS is similar, but more sustained, to that previously observed after surgery. 4. These results indicate a possible functional link between FS, inflammation and the acute-phase response.
authors.affiliation: Department of Anatomy and Physiology, Royal Melbourne Institute of Technology, Bundoora, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Klein
authors.forename: I J
authors.initials: IJ
authors.lastname: Clarke
authors.forename: M P
authors.initials: MP
authors.lastname: Hedger
authors.forename: D M
authors.initials: DM
authors.lastname: Robertson
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D004926:Escherichia coli; D005260:Female; D038681:Follistatin; D006023:Glycoproteins / Q000097:blood*; D007249:Inflammation / Q000139:chemically induced; D008070:Lipopolysaccharides / Q000008:administration & dosage*; D010052:Ovariectomy; D012756:Sheep; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D038681:Follistatin; D006023:Glycoproteins; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha