Esthesioneuroblastoma in the pediatric age-group: the role of chemotherapy and autologous bone marrow transplantation.
Esthesioneuroblastoma, a malignant neoplasm arising from olfactory epithelium, is unusual in the pediatric age-group. Management has traditionally involved surgery and radiotherapy, alone or in combination, with chemotherapy reserved for recurrent or high grade disease. We report a single institution experience utilizing chemotherapy and radiotherapy as the initial treatment and successful control of the primary tumor in two patients. In one patient, neck dissection and high dose chemotherapy combined with autologous bone marrow transplantation were used as successful salvage therapy of neck metastasis. Both patients are alive and disease free with a mean follow-up of 56 months. These results support the role of chemotherapy in the treatment of esthesioneuroblastoma and suggest that chemotherapy be used as part of the initial combined modality treatment plan.
Nguyen
Q A
QA
Department of Otolaryngology-Head and Neck Surgery, Los Angeles County-University of Southern California Medical Center 90033, USA.
Villablanca
J G
JG
Siegel
S E
SE
Crockett
D M
DM
D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D018304:Esthesioneuroblastoma, Olfactory / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D009305:Nasopharynx / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014182:Transplantation, Autologous
D000970:Antineoplastic Agents