Estradiol and progesterone endometrial receptors and body fat distribution in obese women.
The content of endometrial receptors for estradiol (ER) and progesterone (PR) was determined in three groups (10 women each) classified with respect to body fat distribution: (1) normal, nonobese; (2) lower body segment obesity and (3) upper body segment obesity. The ER in group 3 were significantly (p < 0.05) higher than those of group 1. As regards PR, no statistical differences were found among the three groups. These findings demonstrate different endometrial ER concentrations in obese women according to body fat distribution, greater in upper segment obesity. Probably the lack of progesterone as well as other factors in the endocrine milieu of these patients may determine the differences found; therefore, future research on this matter should be carried out.
Morán
C
C
Gynecologic Endocrinology Section, Hospital Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
García-Hernández
E
E
Cortés
M A
MA
Calzada
L
L
Salazar
L
L
Bermúdez
J A
JA
D000328:Adult; D001706:Biopsy; D001824:Body Constitution; D015992:Body Mass Index; D015331:Cohort Studies; D004717:Endometrium / Q000378:metabolism*; D004958:Estradiol / Q000032:analysis / Q000378:metabolism; D005260:Female; D006801:Humans; D009765:Obesity / Q000378:metabolism*; D011374:Progesterone / Q000032:analysis / Q000378:metabolism; D011959:Receptors, Estradiol / Q000032:analysis* / Q000378:metabolism; D011980:Receptors, Progesterone / Q000032:analysis* / Q000378:metabolism
D011959:Receptors, Estradiol; D011980:Receptors, Progesterone; D011374:Progesterone; D004958:Estradiol