title: Molecular characterization of erythrocyte glucose-6-phosphate dehydrogenase deficiency in Al-Ain District, United Arab Emirates.
abstract: In a cross-sectional study, the activity, electrophoretic mobility and genotypes of glucose-6-phosphate dehydrogenase (G6PD) were determined among healthy, UAE national school boys from Al-Ain District in the United Arab Emirates, The prevalence of G6PD deficiency in this population sample was 11%. The majority of G6PD-deficient subjects were descendants of Omani, Baluchi or Yemeni migrants. Of 18 deficient subjects, 16 had an enzyme activity of < 10% of normal while 2 had an activity of just above 10%. Electrophoresis was performed on 166 samples and showed that, apart from deficient samples, all had the normal mobility of G6PD type B. Of the 18 deficient subjects, 14 had the B type mobility of G6PD Mediterranean and 4 had the A type mobility of G6PD A-. Genotyping demonstrated that 10 had the Mediterranean mutation while 3 had the A- mutation, consistent with their electrophoretic mobility. Another 3 had the G6PD Aures mutation, recently described as polymorphic in Algeria and Spain. The mutations in the remaining 2 subjects have not yet been identified.
authors.affiliation: Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University.
authors.forename: R A
authors.initials: RA
authors.lastname: Bayoumi
authors.forename: M S
authors.initials: MS
authors.lastname: Nur-E-Kamal
authors.forename: M
authors.initials: M
authors.lastname: Tadayyon
authors.forename: K K
authors.initials: KK
authors.lastname: Mohamed
authors.forename: B H
authors.initials: BH
authors.lastname: Mahboob
authors.forename: M M
authors.initials: MM
authors.lastname: Qureshi
authors.forename: M S
authors.initials: MS
authors.lastname: Lakhani
authors.forename: M O
authors.initials: MO
authors.lastname: Awaad
authors.forename: J
authors.initials: J
authors.lastname: Kaeda
authors.forename: T J
authors.initials: TJ
authors.lastname: Vulliamy
authors.forename: L
authors.initials: L
authors.lastname: Luzzatto
mesh_terms: D000293:Adolescent; D002648:Child; D004912:Erythrocytes / Q000201:enzymology*; D005838:Genotype; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood* / Q000453:epidemiology; D006801:Humans; D008297:Male; D015995:Prevalence; D014479:United Arab Emirates / Q000453:epidemiology