Survey of antibiotic susceptibility among gram-negative bacilli at a cancer center.
A survey of the susceptibility of gram-negative bacilli isolated from cancer patients to broad-spectrum antimicrobial agents was conducted. The organisms were isolated from all patient specimens submitted to the microbiology laboratory during a 3-month study period. Overall, the least resistance was observed against cefoperazone/sulbactam, ciprofloxacin, and imipenem. Of these, cefoperazone/sulbactam has had limited usage at our institution. Drugs used more frequently (piperacillin, aztreonam, cefoperazone, ceftazidime) were associated with greater levels of resistance. Imipenem and ciprofloxacin have enjoyed wide usage but the level of resistance remains low.
Rolston
K V
KV
Department of Medical Specialties, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Elting
L
L
Waguespack
S
S
Ho
D H
DH
LeBlanc
B
B
Bodey
G P
GP
D000150:Acinetobacter / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology; D001398:Aztreonam / Q000494:pharmacology; D002438:Cefoperazone / Q000008:administration & dosage / Q000494:pharmacology; D002442:Ceftazidime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D004754:Enterobacter / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006801:Humans; D015378:Imipenem / Q000494:pharmacology; D008997:Monobactams / Q000494:pharmacology; D009369:Neoplasms / Q000382:microbiology*; D010406:Penicillins / Q000494:pharmacology; D010878:Piperacillin / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013407:Sulbactam / Q000008:administration & dosage / Q000494:pharmacology; D013845:Thienamycins / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D002511:Cephalosporins; D008997:Monobactams; D010406:Penicillins; D013845:Thienamycins; D002939:Ciprofloxacin; D015378:Imipenem; D002438:Cefoperazone; D002442:Ceftazidime; D001398:Aztreonam; D013407:Sulbactam; D010878:Piperacillin