Effects of anti-inflammatory agents on hydrochloric acid-induced pulmonary injury.
To determine the effects of anti-inflammatory agents on hydrochloric acid lung injury, the heart and lungs were harvested from rats, placed in a lung chamber, constant flow perfused with whole blood, and ventilated. The following experiments were conducted: observation alone; intratracheal injection of normal saline; intratracheal hydrochloric acid; and intravenous meclofenamate or indomethacin before intratracheal hydrochloric acid. Wet-to-dry lung weights were measured. Peak airway pressures increased immediately (p < .001 vs. baseline; ANOVA) in all intratracheal groups, hydrochloric acid producing even greater (p < .05) increases than saline-effects unaltered by meclofenamate or indomethacin. The increased (p < .001 vs. baseline) 2-h pulmonary artery pressures in hydrochloric acid-treated groups were unaltered by meclofenamate or indomethacin. All hydrochloric acid-treated groups demonstrated increases (p < .05) in weight that were unchanged by meclofenamate or indomethacin. These data suggest that the beneficial effects of these medications described elsewhere, using a variety of in vivo lung injury experimental models, may be attributed to their experimental design, or to contributions from organs/systems outside the pulmonary circuit.
Westervelt
C L
CL
Department of Surgery, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Choe
E U
EU
Arya
J
J
Lippton
H L
HL
Flint
L M
LM
Ferrara
J J
JJ
D000208:Acute Disease; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002302:Cardiac Output; D006851:Hydrochloric Acid / Q000009:adverse effects*; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D008469:Meclofenamic Acid / Q000494:pharmacology*; D010477:Perfusion; D011015:Pneumonia, Aspiration / Q000139:chemically induced*; D011669:Pulmonary Wedge Pressure; D051381:Rats; D017207:Rats, Sprague-Dawley; D012119:Respiration; D015656:Respiratory Mechanics / Q000502:physiology; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008469:Meclofenamic Acid; D006851:Hydrochloric Acid; D007213:Indomethacin