Solid phases of delavirdine mesylate.
Delavirdine mesylate was recrystallized from solution under a variety of conditions. Seven crystal forms and a stable amorphous phase were isolated from solution. Two of these crystal forms were polymorphic anhydrates: from XI (U-90152T) and form VIII (U-90152S). Two hydrates (forms VI and XIV), an ethanol solvate (form VII), an acetonitrile solvate (form XIII), and a solvate from methanol/acetone (from XII) were also identified. Six additional phases were identified as the products of solid-state transformations of the hydrated and solvated phases. The solid phases were differentiated by infrared spectroscopy and X-ray powder diffraction. Several of the solid-state phase transformations were mediated by atmospheric moisture. These transformations were studied as a function of relative humidity with dynamic moisture sorption gravimetry (DMSG). DMSG also provided useful measurements of hygroscopicity.
Bergren
M S
MS
Pharmacia and Upjohn Inc., Kalamazoo, MI 49001, USA.
Chao
R S
RS
Meulman
P A
PA
Sarver
R W
RW
Lyster
M A
MA
Havens
J L
JL
Hawley
M
M
D000097:Acetonitriles / Q000737:chemistry; D019380:Anti-HIV Agents / Q000737:chemistry*; D020008:Delavirdine; D007211:Indoles / Q000737:chemistry*; D010879:Piperazines / Q000737:chemistry*; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
D000097:Acetonitriles; D019380:Anti-HIV Agents; D007211:Indoles; D010879:Piperazines; D018894:Reverse Transcriptase Inhibitors; D012997:Solvents; D014867:Water; D020008:Delavirdine