[Distribution of certain nonelectrolytes between intra- and extracellular parts of erythrocytes].
Human red blood cells were balanced at 37 degrees C in 15% solution of the following nonelectrolytes (NE): methanol, ethanol, 1,2-propanediol, diethylene glycol, glycerol, polythelene glycols (PEGs) with molecular masses 300, 400, 600, 1000, 15000. The distribution coefficients (Q) equal to the ratio of the N concentration in cell to that in the intercellular medium, were determined by 1H-NMR technique. A monotonous decrease of the Q values with the increase of the molecular mass of the NE from 1.15 + 0.12 for methanol to 0.12 +/- 0.01 for PEG-1500 has been demonstrated. Results obtained demonstrate that the mixture (PEG) components with different molecular weights and 1,2-PD-PEG-1500 take negligible influence on the distribution coefficients of these substances between erythrocytes and extracellular environment.
Kucherenko
Iu V
IuV
Zinchenko
V D
VD
Khanina
L A
LA
D000438:Alcohols / Q000737:chemistry / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008970:Molecular Weight
D000438:Alcohols