Severe graft versus host disease following liver transplantation confirmed by PCR-HLA-B sequencing: report of a case and literature review.
A case of severe graft versus host disease in a liver transplant recipient is presented. Due to HLA similarity between donor and recipient, the demonstration of cellular chimerism had to be made by PCR-HLA-B sequencing. In addition, we review the literature on this entity emphasizing its poor outcome, the difficulty of the differential diagnosis, and the need for the development of new prophylactic and therapeutic strategies in its management.
Sanchez-Izquierdo
J A
JA
Intensive Care Department, Hospital Doce de Octubre, Complutense School of Medicine, Madrid, Spain.
Lumbreras
C
C
Colina
F
F
Martinez-Laso
J
J
Jiménez
C
C
Gómez
R
R
García
I
I
Alvarez
M
M
Arnaiz-Villena
A
A
Moreno
E
E
D000328:Adult; D006086:Graft vs Host Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D015235:HLA-B Antigens; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D016133:Polymerase Chain Reaction; D018183:Transplantation Chimera
D015235:HLA-B Antigens