Analysis of urinary pyridinoline and deoxypyridinoline in patients undergoing long-term anticonvulsant drug therapy.
Urinary pyridinoline and deoxypyridinoline were analyzed in 23 patients undergoing long-term anticonvulsant drug therapy and compared with those in an age-matched control group, which consisted of 218 healthy premenopausal women. Values of urinary pyridinoline and deoxypyridinoline in the patient group were significantly higher than those in the control group. However, mean serum levels of alkaline phosphatase in the patient group were within the control range. Our data demonstrate that bone resorption is accelerated by long-term anticonvulsant drug therapy and there may be an imbalance between bone resorption and bone formation in the patient group.
Ohishi
T
T
Department of Orthopedic Surgery, Hamamatsu University School of Medicine, Japan.
Kushida
K
K
Takahashi
M
M
Kawana
K
K
Inoue
T
T
Yagi
K
K
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D000596:Amino Acids / Q000652:urine*; D000927:Anticonvulsants / Q000627:therapeutic use*; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000097:blood; D008875:Middle Aged; D012016:Reference Values; D013997:Time Factors
D000596:Amino Acids; D000927:Anticonvulsants; C015484:pyridinoline; C036020:deoxypyridinoline; D000469:Alkaline Phosphatase; D006909:Hydroxyproline; D002118:Calcium