Drug-resistant mycobacterium tuberculosis; some data from Sweden, Estonia and Ethiopia.
Drug-resistant tuberculosis is a threat not only to the estimated 50 million people in the world carrying resistant strains, but also to the success of national TB control programmes. In Sweden, multidrug-resistant (MDR) tuberculosis comprises around 1% of the isolated strains. Isoniazid resistance is found in 7% of strains and resistance to other drugs in < 3%. Of patients with resistant TB 70% are born outside Scandinavia. Preliminary data from Estonia show that close to 20% of the strains are resistant to each of the drugs isoniazid, rifampicin and streptomycin. MDR is seen in around 16%. In a study in Ethiopia isoniazid resistance was found in 46% and MDR in 11% among treatment failures and relapse cases.
Hoffner
S E
SE
Microbiology and Tumorbiology Center, Karolinska Institute and Swedish Institute for Infectious Disease Control, Stockholm, Sweden.
D000995:Antitubercular Agents / Q000627:therapeutic use*; D004957:Estonia / Q000453:epidemiology; D005002:Ethiopia / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D013548:Sweden / Q000453:epidemiology; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000453:epidemiology*
D000995:Antitubercular Agents