Difference of the plasma concentration and urinary excretion of allopurinol, oxypurinol, and purine bases between dietary intake and fasting.
To investigate how much the metabolism of allopurinol, oxypurinol, and purine bases during dietary intake (total calorie 2,083 kcal, total protein 107.5 g, total lipid 74.1 g, total carbohydrate 228.3 g, total purine 180.5 mg) differs from that during fast, allopurinol (300 mg) was administered to 5 normal subjects after a 6-hour fast and then breakfast was taken. Four and 10 hours after the administration of allopurinol lunch and dinner were taken, respectively. Two weeks later the same protocol was performed, except for the intake of only water instead of diet. The fractional clearances and urinary excretions of oxypurinol, uric acid, and the clearance of creatinine were increased by dietary intake, compared with the respective ones resulting from fasting. At the same time the plasma concentrations of hypoxanthine, xanthine, and oxypurinol were decreased in dietary intake, compared with the respective ones in fasting, while the urinary excretion of neither allopurinol, hypoxanthine, nor xanthine was affected. These results suggest that the administration of allopurinol at bed time (during the nocturnal fast) may be more effective than that after breakfast in order to decrease the plasma concentration of uric acid.
Yamamoto
T
T
Third Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan.
Moriwaki
Y
Y
Takahashi
S
S
Tsutsumi
Z
Z
Yamakita
J
J
Higashino
K
K
D000328:Adult; D000493:Allopurinol / Q000008:administration & dosage* / Q000378:metabolism* / Q000494:pharmacology; D004032:Diet; D004791:Enzyme Inhibitors / Q000097:blood* / Q000652:urine*; D005215:Fasting / Q000378:metabolism*; D006074:Gout Suppressants / Q000008:administration & dosage* / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D008297:Male; D010117:Oxypurinol / Q000097:blood* / Q000652:urine*; D014970:Xanthines / Q000378:metabolism*
D004791:Enzyme Inhibitors; D006074:Gout Suppressants; D014970:Xanthines; D000493:Allopurinol; D010117:Oxypurinol