title: The role of MCM/P1 proteins in the licensing of DNA replication.
abstract: The DNA replication licensing system ensures that eukaryotic chromosomes replicate precisely once per cell cycle. A central component of the licensing system, RLF-M, has recently been shown to consist of a complex of Mcm/P1 proteins. This result allows us to integrate data about the MCM/P1 family obtained in different eukaryotes, ranging from yeast to man, into a general picture of the way that chromosome replication is controlled.
authors.affiliation: ICRF Clare Hall Laboratories, South Mimms, UK.
authors.forename: J P
authors.initials: JP
authors.lastname: Chong
authors.forename: P
authors.initials: P
authors.lastname: Thömmes
authors.forename: J J
authors.initials: JJ
authors.lastname: Blow
mesh_terms: D018797:Cell Cycle Proteins / Q000235:genetics / Q000502:physiology; D002868:Chromosomal Proteins, Non-Histone; D004261:DNA Replication; D004268:DNA-Binding Proteins; D005656:Fungal Proteins / Q000235:genetics / Q000502:physiology; D006801:Humans; D064126:Minichromosome Maintenance Complex Component 3; D009154:Mutation; D009687:Nuclear Proteins; D012441:Saccharomyces cerevisiae / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins; D013347:Subcellular Fractions / Q000737:chemistry
chemical_list: D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; C066470:MCM3 protein, human; C069200:MCM5 protein, S cerevisiae; C489423:MCM5 protein, human; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins; C069199:MCM2 protein, S cerevisiae; D064126:Minichromosome Maintenance Complex Component 3