Cellular response in the cerebellum after midline traumatic brain injury in the rat.
We evaluated the response of microglia and Purkinje cells in the cerebellum at 1, 2, 3, 7 and 10 days after a midline fluid percussion brain injury. There was marked activation of microglia and a significant loss of Purkinje cells in the vermis by 7 days postinjury. These findings emphasize the vulnerability of the cerebellum to midline traumatic brain injury.
Mautes
A E
AE
Department of Neurosurgery, University of California, San Francisco, USA.
Fukuda
K
K
Noble
L J
LJ
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D000911:Antibodies, Monoclonal; D001794:Blood Pressure / Q000502:physiology; D001930:Brain Injuries / Q000473:pathology* / Q000503:physiopathology; D002531:Cerebellum / Q000473:pathology*; D002543:Cerebral Hemorrhage / Q000473:pathology / Q000503:physiopathology; D007150:Immunohistochemistry; D008297:Male; D017628:Microglia / Q000502:physiology / Q000648:ultrastructure; D011689:Purkinje Cells / Q000502:physiology / Q000648:ultrastructure; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D000596:Amino Acids; D000911:Antibodies, Monoclonal