title: Preliminary studies of analgesic and anti-inflammatory properties of Caesalpinia ferrea crude extract.
abstract: The crude aqueous extract of the fruits of Caesalpinia ferrea Mart. (Leguminosae) has been investigated for possible anti-inflammatory and analgesic properties. The carrageenan induced rat hind paw edema was significantly inhibited (P < 0.05) by oral administration of 300 mg/kg of this extract. A centrally mediated analgesic effect was not observed, however, there was a dose dependent reduction in the number of total writhes induced by acetic acid.
authors.affiliation: Faculty of Pharmacy, Laboratory of Pharmacognosy, University Estadual Paulista, São Paulo, Brasil.
authors.forename: J C
authors.initials: JC
authors.lastname: Carvalho
authors.forename: J R
authors.initials: JR
authors.lastname: Teixeira
authors.forename: P J
authors.initials: PJ
authors.lastname: Souza
authors.forename: J K
authors.initials: JK
authors.lastname: Bastos
authors.forename: D
authors.initials: D
authors.lastname: dos Santos Filho
authors.forename: S J
authors.initials: SJ
authors.lastname: Sarti
mesh_terms: D019342:Acetic Acid / Q000008:administration & dosage / Q000633:toxicity; D000284:Administration, Oral; D000700:Analgesics / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002351:Carrageenan / Q000008:administration & dosage / Q000633:toxicity; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005079:Excipients / Q000008:administration & dosage / Q000633:toxicity; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D005079:Excipients; D010936:Plant Extracts; D002351:Carrageenan; D019342:Acetic Acid