title: Optical image reconstruction using DC data: simulations and experiments.
abstract: In this paper, we explore optical image formation using a diffusion approximation of light propagation in tissue which is modelled with a finite-element method for optically heterogeneous media. We demonstrate successful image reconstruction based on absolute experimental DC data obtained with a continuous wave 633 nm He-Ne laser system and a 751 nm diode laser system in laboratory phantoms having two optically distinct regions. The experimental systems used exploit a tomographic type of data collection scheme that provides information from which a spatially variable optical property map is deduced. Reconstruction of scattering coefficient only and simultaneous reconstruction of both scattering and absorption profiles in tissue-like phantoms are obtained from measured and simulated data. Images with different contrast levels between the heterogeneity and the background are also reported and the results show that although it is possible to obtain qualitative visual information on the location and size of a heterogeneity, it may not be possible to quantitatively resolve contrast levels or optical properties using reconstructions from DC data only. Sensitivity of image reconstruction to noise in the measurement data is investigated through simulations. The application of boundary constraints has also been addressed.
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
authors.forename: H
authors.initials: H
authors.lastname: Jiang
authors.forename: K D
authors.initials: KD
authors.lastname: Paulsen
authors.forename: U L
authors.initials: UL
authors.lastname: Osterberg
mesh_terms: D000042:Absorption; D000465:Algorithms; D055592:Biophysical Phenomena; D001703:Biophysics; D003198:Computer Simulation; D004058:Diffusion; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation / Q000706:statistics & numerical data*; D007834:Lasers; D055095:Optics and Photonics / Q000295:instrumentation; D019047:Phantoms, Imaging; D012542:Scattering, Radiation