title: Cytotoxic activities of solanum steroidal glycosides.
abstract: Cytotoxic activities of 20 steroidal glycosides obtained from Solanum genera plants were examined against various cell lines to provide new evidence as follows: 1) As regarding the sugar linkage, the glycosides possessing a beta-chacotriosyl moiety were the most effective and the presence of the terminal rhamnosyl residue was required for exhibiting strong activity. 2) As for the aglycone, the glycosides carrying a spirostanol aglycone showed the strongest activity and even an aglycone without a sugar linkage presented considerably strong activity.
authors.affiliation: Faculty of Pharmcaeutical Sciences, Kumamoto University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: C
authors.initials: C
authors.lastname: Komori
authors.forename: Y
authors.initials: Y
authors.lastname: Lee
authors.forename: F
authors.initials: F
authors.lastname: Hashimoto
authors.forename: S
authors.initials: S
authors.lastname: Yahara
authors.forename: T
authors.initials: T
authors.lastname: Nohara
authors.forename: A
authors.initials: A
authors.lastname: Ejima
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D011198:Solanum tuberosum; D013256:Steroids / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D010936:Plant Extracts; D013256:Steroids