title: Craniofacial defects in AP-2 null mutant mice.
abstract: AP-2 is a recent significant addition to the list of transcription factors that have been demonstrated by targeted gene disruption to be essential for normal development. Two recent reports of AP-2 null mutant mice indicate that AP-2 holds a key position in the network of genes and proteins controlling developmental pattern and morphogenesis, and that it is particularly important for development of the cranial region and for midline fusions.
authors.affiliation: University of Colorado Health Sciences Center, Dept of Physiology, Denver 80262, USA.
authors.forename: G M
authors.initials: GM
authors.lastname: Morriss-Kay
mesh_terms: D000818:Animals; D019465:Craniofacial Abnormalities / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000502:physiology*; D005124:Eye Abnormalities / Q000235:genetics; D017880:Limb Deformities, Congenital; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D009432:Neural Crest / Q000002:abnormalities; D010641:Phenotype; D050656:Transcription Factor AP-2; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology*; D014212:Tretinoin / Q000502:physiology
chemical_list: D004268:DNA-Binding Proteins; D050656:Transcription Factor AP-2; D014157:Transcription Factors; D014212:Tretinoin