Plasma follistatin concentrations increase following lipopolysaccharide administration in sheep.
1. The effect of inflammation induced by lipopolysaccharide (LPS) injection on plasma follistatin (FS) concentrations was investigated. 2. Plasma FS and tumour necrosis factor-alpha concentrations increase following LPS administration in ewes. 3. The rise in FS is similar, but more sustained, to that previously observed after surgery. 4. These results indicate a possible functional link between FS, inflammation and the acute-phase response.
Klein
R
R
Department of Anatomy and Physiology, Royal Melbourne Institute of Technology, Bundoora, Australia.
Clarke
I J
IJ
Hedger
M P
MP
Robertson
D M
DM
D000704:Analysis of Variance; D000818:Animals; D004926:Escherichia coli; D005260:Female; D038681:Follistatin; D006023:Glycoproteins / Q000097:blood*; D007249:Inflammation / Q000139:chemically induced; D008070:Lipopolysaccharides / Q000008:administration & dosage*; D010052:Ovariectomy; D012756:Sheep; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D038681:Follistatin; D006023:Glycoproteins; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha