Hemorrheologic effects of pyrimido-pyrimidine derivatives.
A series of pyrimido-pyrimidine derivatives were tested for their effect on membrane fluidity-deformability of human red blood cells and on human platelet aggregation. These agents were also tested for their intracellular cAMP increasing activity and proliferation inhibitory activity in neoplastic cells. The order of activity was established and clinical implications discussed. Several derivatives are under study as antineoplastic agents.
Ambrus
J L
JL
Department of Internal Medicine, University of New York.
Stadler
I
I
Kulaylat
M
M
Koreshi
A
A
Akhtar
S
S
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors; D000244:Adenosine Diphosphate / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D000242:Cyclic AMP / Q000378:metabolism; D004907:Erythrocyte Deformability / Q000187:drug effects; D018056:Hemorheology; D006801:Humans; D008545:Melanoma / Q000378:metabolism; D015394:Molecular Structure; D009012:Mopidamol / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D010975:Platelet Aggregation Inhibitors; D011743:Pyrimidines; D009012:Mopidamol; D000244:Adenosine Diphosphate; D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases