Postantibiotic effect and virulence factors depression induced by ciprofloxacin and by aminoglycosides in a clinical isolate of Pseudomonas aeruginosa.
The postantibiotic effect (PAE) was induced in Pseudomonas aeruginosa by ciprofloxacin, tobramycin and netilmicin (2x or 4x MIC). A longer PAE was evoked by a higher concentration of antibiotics. The evaluation of Pseudomonas aeruginosa virulence factors after treatment with suprainhibitory concentrations of the antibiotics tested showed that a higher suppression of elastase activity was associated with a longer PAE. Elastase was suppressed more effectively than proteinase. The highest reduction of elastase and proteinase activity (to 24.9% and 76.4% of the control values) was observed after treatment with ciprofloxacin.
Hostacka
A
A
Institute of Preventive and Clinical Medicine, Bratislava, Slovakia.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D010450:Endopeptidases / Q000032:analysis; D009428:Netilmicin / Q000494:pharmacology; D010196:Pancreatic Elastase / Q000032:analysis; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000201:enzymology / Q000472:pathogenicity; D014031:Tobramycin / Q000494:pharmacology; D014774:Virulence / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D009428:Netilmicin; D002939:Ciprofloxacin; D010450:Endopeptidases; D010196:Pancreatic Elastase; D014031:Tobramycin