title: Oral 9-cis-retinoic acid versus 13-cis-retinoic acid in acne therapy.
abstract: BACKGROUND
  9-cis-Retinoic acid (9-cis-RA) is as active as 13-cis-retinoic acid (13-cis-RA) in inhibiting the proliferation of cultured human sebocytes and in reducing the size of sebaceous glands of hamsters.
  
  
  OBJECTIVE
  Evaluate the anti-acne effect of 9-cis-RA compared to that of 13-cis-RA in a pilot study.
  
  
  METHODS
  Four young male patients with acne were treated in an open study consecutively with 9-cis-RA and 13-cis-RA given at similar doses.
  
  
  RESULTS
  No beneficial effects were observed with 9-cis-RA in any of the patients whereas all responded favorably to 13-cis-RA.
  
  
  CONCLUSIONS
  For the two retinoids tested, the anti-acne effect correlates with the sebosuppressive effect in humans.
authors.affiliation: F. Hoffmann-La Roche Ltd, Basel, Switzerland.
authors.forename: F
authors.initials: F
authors.lastname: Ott
authors.forename: W
authors.initials: W
authors.lastname: Bollag
authors.forename: J M
authors.initials: JM
authors.lastname: Geiger
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000077556:Alitretinoin; D000818:Animals; D002478:Cells, Cultured; D006224:Cricetinae; D004195:Disease Models, Animal; D006801:Humans; D015474:Isotretinoin / Q000008:administration & dosage / Q000627:therapeutic use*; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D010865:Pilot Projects; D012176:Retinoids / Q000008:administration & dosage / Q000627:therapeutic use*; D012627:Sebaceous Glands / Q000166:cytology / Q000187:drug effects; D012629:Sebum / Q000187:drug effects; D016896:Treatment Outcome; D014212:Tretinoin / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D007641:Keratolytic Agents; D012176:Retinoids; D000077556:Alitretinoin; D014212:Tretinoin; D015474:Isotretinoin