Methylphenidate and attentional training. Comparative effects on behavior and neurocognitive performance in twin girls with attention-deficit/hyperactivity disorder.
The effectiveness of four doses (5-mg, 10-mg, 15-mg, 20-mg) of methylphenidate (MPH) and attentional training (AT) were evaluated using neurocognitive instruments (Continuous Performance Test; Matching Unfamiliar Figures Test), narrow- and broad-band rating scales in the context of a double-blind, placebo-control, within-subject reversal design for dizygotic twin girls with Attention-Deficit/Hyperactivity Disorder (ADHD). Both interventions proved effective for improving neurocognitive test performance and behavior, although broad-band ratings revealed dose-response curves different from those obtained from the neurocognitive tests. Implications for clinical management of girls with ADHD are discussed.
Rapport
M D
MD
Department of Psychology, University of Hawaii, Honolulu 96822, USA. largo@unuhix.uhcc.hawaii.edu
Loo
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S
Isaacs
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P
Goya
S
S
Denney
C
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Scanlan
S
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D001288:Attention / Q000187:drug effects; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics* / Q000523:psychology / Q000628:therapy; D001521:Behavior Therapy; D000697:Central Nervous System Stimulants / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D004200:Diseases in Twins / Q000235:genetics*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007859:Learning Disabilities / Q000235:genetics* / Q000628:therapy; D008774:Methylphenidate / Q000008:administration & dosage*; D009043:Motor Activity / Q000187:drug effects; D009483:Neuropsychological Tests; D010552:Personality Assessment; D014429:Twins, Dizygotic / Q000235:genetics / Q000523:psychology
D000697:Central Nervous System Stimulants; D008774:Methylphenidate