Association between Wegener's granulomatosis and Staphylococcus aureus infection?
Two patients are presented with Wegener's granulomatosis (WG) and lower respiratory tract infections with Staphyloccus aureus (SA). It is posulated that there is a relationship between the infection and the induction or relapse of the disease. We suggest that bronchoalveolar lavages should be performed in cases of suspected WG to identify SA-infections. The co-existence of WG and SA support the reported beneficial effects of sulfamethoxazole/trimethoprim, but needs further evaluation in patients with and without SA-infection of the airways.
van Putten
J W
JW
University Hospital, Dept of Pulmonary Medicine, Utrecht, The Netherlands.
van Haren
E H
EH
Lammers
J W
JW
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D015169:Colony Count, Microbial; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D008875:Middle Aged; D009666:Nose / Q000382:microbiology; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000150:complications* / Q000188:drug therapy; D013183:Sputum / Q000382:microbiology; D013203:Staphylococcal Infections / Q000150:complications* / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000302:isolation & purification; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination