Molecular mechanisms in the regulation of renal proximal tubular Na/phosphate cotransport.
Renal proximal tubular Na/phosphate cotransport is the key target in the control of renal phosphate handling. Using molecular tools for the type II Na/phosphate cotransporter, it could be documented that altered brush border membrane phosphate transport reflects a state of altered brush border expression of the specific transporter molecule. This alteration is either the consequence of specific membrane insertion/retrieval processes and/or reflects states of altered synthesisdegradation of the transporter.
Murer
H
H
Physiologisches Institut, Zürich, Schweiz.
Lötscher
M
M
Kaissling
B
B
Biber
J
J
D000042:Absorption; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D017674:Hypophosphatemia / Q000235:genetics / Q000378:metabolism; D017136:Ion Transport; D007687:Kidney Tubules, Proximal / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism*; D016226:Phosphorus, Dietary / Q000493:pharmacokinetics; D012964:Sodium / Q000378:metabolism*; D050608:Sodium-Phosphate Cotransporter Proteins; D050610:Sodium-Phosphate Cotransporter Proteins, Type II; D027981:Symporters
D002352:Carrier Proteins; D010710:Phosphates; D016226:Phosphorus, Dietary; D050608:Sodium-Phosphate Cotransporter Proteins; D050610:Sodium-Phosphate Cotransporter Proteins, Type II; D027981:Symporters; D012964:Sodium