title: Subtraction procedure for the registration of tissue perfusion with Doppler ultrasound.
abstract: Tissue perfusion, i.e., in muscles or parenchymatous organs, is of both physiological and pathophysiological interest. The measurement of tissue perfusion is an unsolved problem. The Doppler ultrasound method is well suited to this purpose. However, measurements using this technique may be disturbed by movements or vibrations such as heart motion, muscle trembling or vibration of the subsoil (i.e. the examination table). These interfering movements produce Doppler frequencies in the same frequency range as slowly flowing erythrocytes, causing artifacts to appear in the measured data. The goal of this project was to suppress such artifacts with the help of a subtraction procedure. The mathematical theory of this subtraction procedure and its implementation in a newly developed two channel Doppler system are presented. This system was successfully tested on a phantom which is able to generate flow and movement artifacts. Preliminary measurements in the forearms of volunteers showed that movement artifacts can be at least partially suppressed.
authors.affiliation: Institute of Biomedical Engineering and Medical Informatics, University and ETH Zurich, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Bührer
authors.forename: U T
authors.initials: UT
authors.lastname: Moser
authors.forename: P M
authors.initials: PM
authors.lastname: Schumacher
authors.forename: T
authors.initials: T
authors.lastname: Pasch
authors.forename: M
authors.initials: M
authors.lastname: Anliker
mesh_terms: D000328:Adult; D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology; D005542:Forearm / Q000098:blood supply* / Q000000981:diagnostic imaging; D006801:Humans; D006940:Hyperemia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D007091:Image Processing, Computer-Assisted; D008297:Male; D008833:Microcirculation / Q000502:physiology; D008962:Models, Theoretical; D010477:Perfusion; D019047:Phantoms, Imaging; D013382:Subtraction Technique; D018608:Ultrasonography, Doppler