title: Garlic powder in the treatment of moderate hyperlipidaemia: a controlled trial and meta-analysis.
abstract: OBJECTIVE
  To determine the effect of 900 mg/day of dried garlic powder (standardised to 1.3% allicin) in reducing total cholesterol.
  
  
  METHODS
  Double-blind, randomised six-month parallel trial.
  
  
  METHODS
  115 individuals with a repeat total cholesterol concentration of 6.0-8.5 mmol/l and low-density lipoprotein (LDL) cholesterol of 3.5 mmol/l or above after six weeks of dietary advice.
  
  
  METHODS
  The active treatment group received dried garlic tablets (standardised to 1.3% allicin) at a dosage of 300 mg three times daily. The control group received a matching placebo.
  
  
  METHODS
  Primary end-point: total cholesterol concentration; secondary end-points: concentrations of LDL and high-density lipoprotein cholesterol, apolipoproteins (apo) A1 and B, and triglycerides.
  
  
  RESULTS
  There were no significant differences between the groups receiving garlic and placebo in the mean concentrations of serum lipids, lipoproteins or apo A1 or B, by analysis either on intention-to-treat or treatment received. In a meta-analysis which included the results from this trial, garlic was associated with a mean reduction in total cholesterol of -0.65 mmol/l (95% confidence intervals: -0.53 to -0.76).
  
  
  CONCLUSIONS
  In this trial, garlic was less effective in reducing total cholesterol than suggested by previous meta-analyses. Possible explanations are publication bias, overestimation of treatment effects in trials with inadequate concealment of treatment allocation, or a type 2 error. We conclude that meta-analyses should be interpreted critically and with particular caution if the constituent trials are small.
authors.affiliation: Department of Public Health and Primary Care, University of Oxford.
authors.forename: H A
authors.initials: HA
authors.lastname: Neil
authors.forename: C A
authors.initials: CA
authors.lastname: Silagy
authors.forename: T
authors.initials: T
authors.lastname: Lancaster
authors.forename: J
authors.initials: J
authors.lastname: Hodgeman
authors.forename: K
authors.initials: K
authors.lastname: Vos
authors.forename: J W
authors.initials: JW
authors.lastname: Moore
authors.forename: L
authors.initials: L
authors.lastname: Jones
authors.forename: J
authors.initials: J
authors.lastname: Cahill
authors.forename: G H
authors.initials: GH
authors.lastname: Fowler
mesh_terms: D000704:Analysis of Variance; D001053:Apolipoproteins / Q000097:blood; D002784:Cholesterol / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D005737:Garlic / Q000009:adverse effects; D006209:Halitosis / Q000209:etiology; D006801:Humans; D006949:Hyperlipidemias / Q000628:therapy*; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D010946:Plants, Medicinal; D014280:Triglycerides / Q000097:blood
chemical_list: D001053:Apolipoproteins; D014280:Triglycerides; D002784:Cholesterol