An early lesion of the lateral septal nuclei produces changes in the forced swim test depending on gender.
1. Several pharmacological maneuvers in very young rats produce later changes resembling human depression. 2. Rats were submitted to a wide lesion in lateral septal region at 8th day after birth and forced to swim at maturity. 3. Male lesioned group showed the highest amount of immobility; whereas, female sham lesion group showed a greater response to treatments. 4. A gender-dependent sensitivity to early lateral septal nucleus lesions and to antidepressants are concluded.
Contreras
C M
CM
Departamento de Fisiología, Instituto de Investigaciones Biomédicas, UNAM, México.
Lara-Morales
H
H
Molina-Hernández
M
M
Saavedra
M
M
Arrellín-Rosas
G
G
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D003672:Defecation / Q000502:physiology; D003863:Depression / Q000523:psychology*; D005260:Female; D008297:Male; D009043:Motor Activity / Q000502:physiology; D051381:Rats; D012727:Sex Characteristics; D013550:Swimming
D000928:Antidepressive Agents