title: Selective approaches to basic neurobehavioral testing of children in environmental health studies.
abstract: To identify neurotoxic effects in children living near hazardous waste sites, the Agency for Toxic Substances and Disease Registry (ATSDR) has designed a basic Pediatric Environmental Neurobehavioral Test Battery (PENTB) for children 1 through 16 years of age. It emphasizes tests appropriate to the stages of a child's development. These stages were fundamental factors in selecting tests for the PENTB, which includes both informant- and performance-based assessment procedures. Assessment of children under 4 years of age is restricted to four informant-based instruments, to evaluate as many functions as possible while minimizing testing time and the professional expertise needed in the test setting. The assessment of children 4 through 16 years of age includes 10 performance-based tests to evaluate key functions within the cognitive, motor, and sensory domains analogous to functions affected by neurotoxic chemicals in adults. In all age groups, it is crucial to also assess family, cultural, economic, and other potentially confounding variables.
authors.affiliation: US Department of Health and Human Services, Agency for Toxic Substances and Disease Registry, Atlanta, GA 30333, USA. rwa1@atsoaal.em.cdc.gov
authors.forename: R W
authors.initials: RW
authors.lastname: Amler
authors.forename: M
authors.initials: M
authors.lastname: Gibertini
authors.forename: J A
authors.initials: JA
authors.lastname: Lybarger
authors.forename: A
authors.initials: A
authors.lastname: Hall
authors.forename: K
authors.initials: K
authors.lastname: Kakolewski
authors.forename: B L
authors.initials: BL
authors.lastname: Phifer
authors.forename: K L
authors.initials: KL
authors.lastname: Olsen
mesh_terms: D002648:Child; D002657:Child Development; D003430:Cross-Sectional Studies; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004781:Environmental Exposure / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000633:toxicity*; D005190:Family; D006256:Hazardous Waste; D006801:Humans; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D011597:Psychomotor Performance / Q000502:physiology; D012959:Socioeconomic Factors
chemical_list: D004785:Environmental Pollutants; D006256:Hazardous Waste