CRH-R1 mRNA expression in two strains of inbred mice and its regulation after repeated restraint stress.
Using in-situ hybridization histochemistry we investigated the distribution of CRH receptor 1 (CRH-R1) mRNA in the cortex of C57BL/6 (C57) and DBA/2 (DBA) strains and its regulation after repeated restraint stress. We show that DBA mice have a higher concentration of CRH-R1 mRNA than C57 mice. Repeated restraint stress produced an increase in CRH-R1 mRNA expression of C57 mice, whereas it was uneffective in DBA mice.
Giardino
L
L
Institute of Otolaryngology II, University of Milan, Modena, Italy.
Puglisi-Allegra
S
S
Ceccatelli
S
S
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000378:metabolism*; D008811:Mice, Inbred DBA / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000378:metabolism*
D012333:RNA, Messenger; D003346:Corticotropin-Releasing Hormone