1,25-Dihydroxyvitamin D(3) receptors in developing dorsal root ganglia of fetal rats.
We observed immunostaining for the 1,25-dihydroxyvitamin D(3) receptor (VDR) and calbindin-D(28k) in neurons, but not glial cells, of fetal rat dorsal root ganglia (DRG) from days 13 through 21 of gestation. Dispersed cultures of DRG collected from rat fetuses at gestational day 15 also contained epitopes for VDR and calbindin-D(28k) in neurons, but not in glial cells. 1,25-Dihydroxyvitamin D(3), through VDR, may perform significant functions in the development of neuronal cells.
Johnson
J A
JA
Nephrology Research Unit, Mayo Clinic/Foundation, Rochester, MN, USA.
Grande
J P
JP
Windebank
A J
AJ
Kumar
R
R
D000818:Animals; D064026:Calbindins; D002478:Cells, Cultured; D046508:Culture Techniques; D004622:Embryo, Mammalian / Q000166:cytology / Q000378:metabolism; D005727:Ganglia, Spinal / Q000166:cytology / Q000196:embryology* / Q000378:metabolism*; D007150:Immunohistochemistry; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009457:Neuroglia / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D051381:Rats / Q000196:embryology; D017207:Rats, Sprague-Dawley; D018167:Receptors, Calcitriol / Q000378:metabolism*; D064030:S100 Calcium Binding Protein G / Q000378:metabolism
D064026:Calbindins; D009419:Nerve Tissue Proteins; D018167:Receptors, Calcitriol; D064030:S100 Calcium Binding Protein G