Replication of hepatitis delta virus.
Hepatitis delta virus (HDV) is a unique viroid-like human pathogen that is always associated with hepatitis B infection. Replication of HDV involves the transcription of genomic RNA, probably by the host RNA polymerase II, by a rolling circle mechanism followed by self-cleavage and self-ligation. Editing of antigenomic RNA, possibly involving the enzyme adenosine deaminase, generates two functionally distinct forms of delta antigen. The molecular basis for HDV pathogenicity remains uncertain.
Monjardino
J
J
Division of Medicine, Imperial College School of Medicine, St. Mary's Hospital, London, UK.
D000619:Aminohydrolases / Q000378:metabolism; D006509:Hepatitis B / Q000150:complications; D003698:Hepatitis Delta Virus / Q000502:physiology*; D006801:Humans; D012319:RNA Polymerase II / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D012367:RNA, Viral / Q000096:biosynthesis; D014158:Transcription, Genetic; D014779:Virus Replication
D012367:RNA, Viral; D012319:RNA Polymerase II; D000619:Aminohydrolases; C018774:adenine deaminase