Functional renal maturation in rat neonates after prenatal exposure to furosemide.
We investigated the pattern of functional renal maturation and electrolyte handling on postnatal day 1, (PD1), day 5 (PD5), and day 12 (PD12) in rat neonates, after mothers were given furosemide during pregnancy. The drug was administered (75 mg/kg per day i.p.) on day 7-11 (organogenesis) and 14-18 (nephrogenesis) of gestation. On PD1 and PD5, there was a disturbance of the urinary concentrating ability with a hyperdiuresis and an over-stimulated ionic exchange, mainly the distal sodium reabsorption. From PD1 to PD12, a progressive functional recovery in electrolyte handling appeared. However, on PD12, when nephrogenesis was achieved, the renal concentrating defect remained. We discuss the possibility of a drug-induced delay in the development of the loop of Henle, leading to functional and morphological adaptations of already developed parts of the nephron.
Mallie
J P
JP
Laboratoire de Néphrologie, Faculté de Médicine de Nancy, Vandoeuvre Les Nancy, France.
Boudzoumou
P
P
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D004232:Diuretics / Q000494:pharmacology*; D004573:Electrolytes / Q000652:urine; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain / Q000187:drug effects
D004232:Diuretics; D004573:Electrolytes; D005665:Furosemide