title: Fulminant malignant hyperthermia associated with ketoacidotic diabetic coma.
abstract: Malignant hyperthermia (MH) in humans is usually triggered by volatile anaesthetics and depolarizing muscle relaxants. However, other factors or drugs (e.g. cresol) are thought to induce MH. We report a case of fulminant MH associated with a ketoacidotic diabetic coma. After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness. MH was treated immediately with dantrolene; the patient recovered within 14 days. Five months later the patient was diagnosed as MH-susceptible by the in vitro caffeine and halothane contracture test. This case supports the assessment that MH and diabetes are associated diseases and that cresol could possibly trigger MH. Furthermore, therapy with dantrolene has been demonstrated to be beneficial in the treatment of MH associated with diabetic coma.
authors.affiliation: Abteilung für Anästhesiologie, Universitäts-Krankenhaus Eppendorf, Hamburg, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Wappler
authors.forename: N
authors.initials: N
authors.lastname: Roewer
authors.forename: A
authors.initials: A
authors.lastname: Köchling
authors.forename: H
authors.initials: H
authors.lastname: Braune
authors.forename: T
authors.initials: T
authors.lastname: Reissinger
authors.forename: J
authors.initials: J
authors.lastname: Schulte am Esch
mesh_terms: D000328:Adult; D002110:Caffeine; D003408:Cresols / Q000009:adverse effects; D003620:Dantrolene / Q000627:therapeutic use; D003926:Diabetic Coma / Q000150:complications; D016883:Diabetic Ketoacidosis / Q000150:complications*; D005334:Fever / Q000188:drug therapy / Q000209:etiology*; D006221:Halothane; D006801:Humans; D008297:Male; D009125:Muscle Relaxants, Central / Q000627:therapeutic use
chemical_list: D003408:Cresols; D009125:Muscle Relaxants, Central; D002110:Caffeine; D003620:Dantrolene; C077977:cresol; D006221:Halothane