Subarachnoid hemorrhage diagnosis: lumbar puncture is still needed when the computed tomography scan is normal.
OBJECTIVE
To determine the sensitivity of third-generation CT scanners for diagnosed nontraumatic subarachnoid hemorrhage (SAH) and to assess the impact of symptom duration on sensitivity.


METHODS
A retrospective chart review was performed in a university-affiliated tertiary care hospital with an annual ED volume of > 100,000 patients. The target population was all patients who presented to the ED from January 1991 to September 1994 with symptoms suggestive of SAH and who had a final diagnosis of nontraumatic SAH based on either a positive CT scan or positive spinal fluid analysis. Patients referred from outside facilities were included if they had a CT done at the study site. All CT scans were done using third-generation scanners. Official CT scan reports were used to categorize scans as positive or negative.


RESULTS
There were 140 patients identified with SAH, with a mean age of 56 years (range 10-88). The sensitivity of CT in the diagnosis of nontraumatic SAH when performed at or before 12 hours of symptom duration was 100% (80/80), and 81.7% (49/60) after 12 hours of symptom duration (95% CI 95-100% and 69.5-90.4%, respectively; p < 0.0001). Eleven of the 140 patients had a negative CT and positive spinal fluid analysis, yielding an overall sensitivity of 92.1% (129/140).


CONCLUSIONS
The sensitivity of third-generation CT scans for SAH decreases with time from the onset of symptoms. In this sample population, CT was able to detect all patients scanned < or = 12 hours after symptom onset. Although the study demonstrated good sensitivity of CT scan reports for SAH when the scan was performed after < or = 12 hours of symptom onset, additional real-time experience is needed to better define the potential risk of a missed SAH should this population not receive the customary lumbar puncture examination in the setting of a negative CT scan.
Sidman
R
R
Brown University School of Medicine, Department of Emergency Medicine, Rhode Island Hospital, Providence 02903, USA. robert.sidman@brown.edu
Connolly
E
E
Lemke
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D004635:Emergency Medicine; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013129:Spinal Puncture; D013345:Subarachnoid Hemorrhage / Q000145:classification / Q000175:diagnosis*; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000592:standards*