Resolution of recurrent malignant ganglioglioma after treatment with cis-retinoic acid.
Ganglioglioma is an uncommon brain tumor with glial and neuronal cellular components and a somewhat benign course. We are presenting an unusual case of ganglioglioma with malignant transformation in both cellular components associated with an aggressive clinical course. An almost complete resolution of the recurrent progressing tumor was achieved after treatment with cis-retinoic acid (cRA) as a single agent. A possible differential effect of cRA on the neuronal component of the tumor is suggested.
Kaba
S E
SE
Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, USA.
Langford
L A
LA
Yung
W K
WK
Kyritsis
A P
AP
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology; D018303:Ganglioglioma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000473:pathology
D000970:Antineoplastic Agents; D015474:Isotretinoin