The neuroimmunology of multiple sclerosis.
The aim of this clinical review is to highlight recent advances in immunology, as well as new information from selected other areas, which have led to a better appreciation of the neuroimmunologic mechanisms involved in Multiple sclerosis (MS). New data on immunopathology, the cytokine network, and the role of oligodendrocytes, lymphocytes, and endothelial cells in this disease, have produced novel therapeutic approaches. New information on clinical course and neuroimaging disease features, as well as the role of genetic factors and infectious agents, have also improved our understanding of the immune basis for MS.
Coyle
P K
PK
Department of Neurology, Health Sciences Center, SUNY at Stony Brook 11794, USA.
D000328:Adult; D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology* / Q000473:pathology / Q000523:psychology; D016207:Cytokines / Q000502:physiology; D004198:Disease Susceptibility; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000209:etiology / Q000276:immunology* / Q000473:pathology / Q000523:psychology; D009186:Myelin Sheath / Q000276:immunology; D015213:Neuroimmunomodulation; D009836:Oligodendroglia / Q000502:physiology; D011379:Prognosis; D011598:Psychoneuroimmunology; D051381:Rats; D013312:Stress, Physiological / Q000150:complications / Q000276:immunology; D014777:Virus Diseases / Q000150:complications / Q000276:immunology
D016207:Cytokines