title: Evaluation of gastric ulcer healing with mucosal microvascular architecture.
abstract: OBJECTIVE
  There is presently no consensus on how long treatment of gastric ulcers should be continued to prevent ulcer recurrence. Therefore, we investigated the histologic state of healing, and the recurrence of gastric ulcers with Helicobacter pylori infection classified by gastric mucosal microvascular architecture as completely and incompletely healed.
  
  
  METHODS
  We obtained biopsy specimens from healed gastric ulcers in 71 patients who had been treated for eight weeks with omeprazole. The gastric mucosal microvascular architecture of the biopsy specimens was observed by the alkaline phosphatase staining method.
  
  
  RESULTS
  We found a significant correlation between the mucosal microvascular architecture in the biopsy specimens and the histologic state of ulcer healing Recurrences were significantly more frequent in ulcers classified by microvascular architecture as incompletely healed than in completely healed ulcers.
  
  
  CONCLUSIONS
  Observing the microvascular architecture of healed gastric ulcers is very useful for judging the state of healing, and therapy should be continued until ulcers are classified by this method as completely healed.
authors.affiliation: Department of Gastroenterology, Osaka Medical Center for Cancer and Cardiovascular Diseases.
authors.forename: Y
authors.initials: Y
authors.lastname: Nagasawa
authors.forename: H
authors.initials: H
authors.lastname: Ishikawa
authors.forename: H
authors.initials: H
authors.lastname: Iishi
authors.forename: M
authors.initials: M
authors.lastname: Tatsuta
authors.forename: S
authors.initials: S
authors.lastname: Ishiguro
mesh_terms: D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply / Q000473:pathology*; D016998:Helicobacter; D016481:Helicobacter Infections / Q000473:pathology; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000473:pathology; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use; D012008:Recurrence; D013276:Stomach Ulcer / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D013997:Time Factors; D014945:Wound Healing
chemical_list: D000897:Anti-Ulcer Agents; D009853:Omeprazole