title: The intracellular origin of the melanosome in pigment cells: a review of ultrastructural data.
abstract: This paper is a review about the ultrastructural data dealing with the origin of the melanin granules in retinal pigment epithelial cells, in melanocytes, in the ink gland of cuttle fish, in Kupffer cells of the liver, in neuronal tissues, in cultured pigment cells. The role and structure of lysosomes in melanogenesis are discussed in a separate chapter. The early steps of melanogenesis are ultrastructurally very heterogeneous, even in the same cell types. With respect to this heterogeneity and the considerably different views on melanosome origin in the literature, the author hypothesizes that pigment cells may use protein matrices originated from different cellular pathways. 1) They may either produce a specific protein matrix and be converted into melanin in the classical way, or 2) alternatively, a matrix resulting from lysosomal protein degradation or endocytotic pathways may be used and converted into melanin, as found in fibroblasts transfected with the tyrosinase gen or in Kupffer cells. The very heterogeneous ultrastructure of the polymerizing melanin may be influenced by the amount and sterical availability of tyrosine residues in the protein moieties and the activity of tyrosinase.
authors.affiliation: Institut fur Anatomie, Universitat zu Koln, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Schraermeyer
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D007728:Kupffer Cells / Q000648:ultrastructure; D008247:Lysosomes / Q000648:ultrastructure; D008543:Melanins / Q000032:analysis; D008544:Melanocytes / Q000648:ultrastructure*; D010857:Pigment Epithelium of Eye / Q000648:ultrastructure
chemical_list: D008543:Melanins; C014121:neuromelanin