title: Bradykinin excretion is increased in severely hyperglycemic streptozotocin-diabetic rats.
abstract: The renal kallikrein-kinin system (KKS) was studied in pair-fed streptozotocin (STZ)-induced diabetic rats and compared with age-matched controls. Twelve weeks after STZ injection, rats were normotensive, showed hyperglycemia, proteinuria, polydipsia and reduced glomerular filtration rate (GFR) and body weight. The activities of urinary prekallikrein (PKLK) and kallikrein (KLK) were reduced accompanied by an up to 3-fold increase of bradykinin (BK) excretion compared to controls. The increased BK excretion suggests that the renal KKS in STZ-diabetes is activated and that the reduction in urinary PKLK and KLK activity may be due to an increased consumption of these enzymes or to a negative feedback mechanism. The stimulation of the renal KKS in STZ-diabetes could reflect an attempt of the organism to balance glomerular hypertension.
authors.affiliation: Department of Pharmacology, Christian-Albrechts University of Kiel, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Tschöpe
authors.forename: V
authors.initials: V
authors.lastname: Gavriluk
authors.forename: A
authors.initials: A
authors.lastname: Reinecke
authors.forename: U
authors.initials: U
authors.lastname: Seidl
authors.forename: U
authors.initials: U
authors.lastname: Riester
authors.forename: U
authors.initials: U
authors.lastname: Hilgenfeldt
authors.forename: E
authors.initials: E
authors.lastname: Ritz
authors.forename: T
authors.initials: T
authors.lastname: Unger
mesh_terms: D000818:Animals; D001920:Bradykinin / Q000652:urine*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology / Q000652:urine*; D006943:Hyperglycemia / Q000503:physiopathology / Q000652:urine*; D016234:Kallikrein-Kinin System / Q000502:physiology; D007610:Kallikreins / Q000652:urine; D008297:Male; D011288:Prekallikrein / Q000652:urine; D051381:Rats; D017208:Rats, Wistar
chemical_list: D011288:Prekallikrein; D007610:Kallikreins; D001920:Bradykinin