Mutagenicity of chemicals produced from sodium dodecylbenzenesulfonate by treatment with ozone and ultraviolet irradiation.
The interaction of formaldehyde and glyoxal produced from linear dodecylbenzenesulfonate (DBS) in aqueous solution after simultaneous treatment with ozone and ultraviolet (UV) irradiation and the effect of DBS on the mutagenic activity of formaldehyde and glyoxal were investigated. The decomposition of DBS in aqueous solution resulted in the formation of the mutagens formaldehyde and glyoxal as intermediate products after the simultaneous treatment for 4 hr. Therefore, the aqueous solution containing decomposed DBS after the treatment for 4 hr was mutagenic for Salmonella typhimurium strains TA100 and TA104 in the presence and absence of S9 mix. However, the mutagenic activity was greater than the sum of the mutagenic activity of formaldehyde and glyoxal formed from DBS. The aqueous solution mixed with formaldehyde and glyoxal did not increase the mutagenicity above the sum of the mutagenic activity in the presence or absence of DBS. Furthermore, DBS at concentrations of 2.0 micrograms/plate or less did not affect the mutagenicity of the mixtures containing formaldehyde and glyoxal. In addition, there was little bacteriocidal effect of the mixed solution on the mutagenicity test strains. These results suggest that unidentified mutagenic intermediate products were produced from DBS after simultaneous treatment with ozone and UV irradiation for 4 hr.
Murakami
K
K
Department of Bacteriology, School of Medicine, University of Tokushima, Japan.
Kinouchi
T
T
Matsumoto
H
H
Ohnishi
Y
Y
D000818:Animals; D001557:Benzenesulfonates / Q000378:metabolism / Q000528:radiation effects / Q000633:toxicity*; D005557:Formaldehyde / Q000633:toxicity; D006037:Glyoxal / Q000633:toxicity; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism / Q000528:radiation effects / Q000633:toxicity*; D010126:Ozone / Q000633:toxicity; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D014466:Ultraviolet Rays / Q000009:adverse effects; D014874:Water Pollutants, Chemical / Q000378:metabolism / Q000528:radiation effects / Q000633:toxicity
D001557:Benzenesulfonates; D009153:Mutagens; D014874:Water Pollutants, Chemical; D005557:Formaldehyde; D006037:Glyoxal; C001114:dodecylbenzenesulfonic acid; D010126:Ozone