title: The clinical significance of calculated versus measured creatinine clearance in patients with gynecologic malignancy.
abstract: Measurement of creatinine clearance remains in convenient because of the need for 24-hour urine collection. Our study compared creatinine clearance calculated from serum creatinine (CC alpha) to measured creatinine clearance (MC alpha) using an unsupervised 8-hour urine collection at home. Forty-two women admitted to our gynecologic oncology service participated in this study. Twenty-six of these patients had cancer originating from the ovaries, 8 from the uterus, 7 from the cervix, and 1 from the fallopian tube. There were adequate data for 61 collections. MC alpha using unsupervised 8-hour urine collection at home correlated well with CC alpha. This calculated value may be sufficient to be used as a guide in evaluating renal function in patients with gynecologic malignancy. However, if it becomes necessary to measure creatinine clearance, our data suggest that an 8-hour collection may be used.
authors.affiliation: Department of Obstetrics and Gynecology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa 33612, USA.
authors.forename: P S
authors.initials: PS
authors.lastname: Rao
authors.forename: J V
authors.initials: JV
authors.lastname: Fiorica
authors.forename: R P
authors.initials: RP
authors.lastname: Shah
authors.forename: L
authors.initials: L
authors.lastname: Graham
authors.forename: W S
authors.initials: WS
authors.lastname: Roberts
authors.forename: M S
authors.initials: MS
authors.lastname: Hoffman
authors.forename: D
authors.initials: D
authors.lastname: Cavanagh
mesh_terms: D000367:Age Factors; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001835:Body Weight; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood / Q000652:urine*; D005185:Fallopian Tube Neoplasms / Q000097:blood / Q000188:drug therapy / Q000652:urine; D005260:Female; D005833:Genital Neoplasms, Female / Q000097:blood / Q000188:drug therapy / Q000652:urine*; D006801:Humans; D007668:Kidney / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000097:blood / Q000188:drug therapy / Q000652:urine; D012648:Self Care; D013048:Specimen Handling; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000188:drug therapy / Q000652:urine; D014594:Uterine Neoplasms / Q000097:blood / Q000188:drug therapy / Q000652:urine
chemical_list: D000970:Antineoplastic Agents; D003404:Creatinine; D002945:Cisplatin