Mechanisms regulating eosinophil extravasation in asthma.
Infiltration of eosinophils into tissue allergic inflammation is mediated by a combination of processes. Eosinophil L-selection and very late activation antigen (VLA-4) can selectively regulate eosinophil adhesion to the endothelium. Activating cytokines, such as interleukin (IL)-5, regulated upon activation in normal T-cells (RANTES) and monocyte chemotactic peptide (MCP)-3 specifically act on eosinophils. Moreover, eosinophils from allergic individuals can be primed for increased adhesion and movement by chemokines released at sites of allergic inflammation. Together, these processes induce a specific infiltration of eosinophils.
Knol
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EF
Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, University of Amsterdam, The Netherlands.
Roos
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D000818:Animals; D019138:Antibodies, Blocking / Q000276:immunology; D002448:Cell Adhesion / Q000276:immunology / Q000502:physiology; D002465:Cell Movement / Q000276:immunology*; D018946:Chemokine CCL5 / Q000096:biosynthesis / Q000276:immunology; D054410:Chemokine CCL7; D002633:Chemotaxis / Q000276:immunology; D016207:Cytokines; D004727:Endothelium / Q000502:physiology; D004804:Eosinophils / Q000276:immunology*; D006168:Guinea Pigs; D006470:Hemorrhage / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007249:Inflammation / Q000503:physiopathology; D039041:Integrin alpha4beta1; D016023:Integrins / Q000276:immunology / Q000502:physiology; D018799:Intercellular Adhesion Molecule-1 / Q000502:physiology; D015848:Interleukin-5 / Q000096:biosynthesis / Q000276:immunology; D018945:Monocyte Chemoattractant Proteins / Q000096:biosynthesis / Q000276:immunology; D016201:Receptors, Lymphocyte Homing / Q000276:immunology / Q000502:physiology; D019087:Selectins / Q000276:immunology / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
D019138:Antibodies, Blocking; C515450:CCL7 protein, human; D018946:Chemokine CCL5; D054410:Chemokine CCL7; D016207:Cytokines; D039041:Integrin alpha4beta1; D016023:Integrins; D015848:Interleukin-5; D018945:Monocyte Chemoattractant Proteins; D016201:Receptors, Lymphocyte Homing; D019087:Selectins; D018799:Intercellular Adhesion Molecule-1