Sclerosing peritonitis associated with luteinized thecoma of the ovary.
A unique case of bilateral luteinized thecomas of the ovary associated with sclerosing peritonitis is reported and the clinical and pathological features of this and previously reported cases are reviewed. The patient, 52 years of age, presented with abdominal distension and diarrhea. Pelvic imaging studies revealed bilateral ovarian tumors with ascites. Total abdominal hysterectomy and bilateral salpingo-oophorectomy with adhesiotomy of the small bowel were performed. Histologically, the ovarian tumor was composed of closely packed spindle to round-shaped cells, and within the spindle cell population, lutein-like cells were scattered singly or in clusters. Mitotic counts of spindle cells revealed 12 mitotic figures (MF) per 10 high-power fields (HPF) in one part of the left ovarian tumor, but other areas of the tumor showed less than 3 MF/10 HPF on average. The lesion from the resected small bowel showed prominent fibrosis, confined to the serosa with no evidence of metastasis from the ovarian tumor. The patient has undergone adhesiotomy with partial resection of the small bowel seven times since the first laparotomy because of the recurrent small bowel obstruction. The patient has survived with complications due to short bowel syndrome for 7 years after the initial surgery and so far no recurrence or metastasis of the ovarian tumor has been identified. The case reported here also supports the idea that luteinized thecoma of the ovary associated with sclerosing peritonitis may be a distinct clinicopathologic entity, in terms of the unique association and of the unique features of thecoma; that is, bilateral, hormonally inactive and apparently benign in spite of its highly mitotic activity. Additional attention should be paid to the patient's quality of life, which is often degraded by peritoneal fibrosis and small bowel obstruction.
Iwasa
Y
Y
Laboratory of Anatomic Pathology, Kyoto University Hospital, Kyoto, Japan.
Minamiguchi
S
S
Konishi
I
I
Onodera
H
H
Zhou
J
J
Yamabe
H
H
D005260:Female; D006801:Humans; D018311:Luteoma / Q000150:complications / Q000473:pathology*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*; D010538:Peritonitis / Q000209:etiology* / Q000473:pathology*; D012598:Sclerosis / Q000473:pathology; D013798:Thecoma / Q000150:complications* / Q000473:pathology*