title: Effect of acute respiratory acidosis on the limits of oxygen extraction during hemorrhage.
abstract: BACKGROUND
  Hypercapnia can impair cells' capacity to maintain energy status anerobically and enhances the risk of hypoxic injury when oxygen availability is reduced. The ability to maintain tissue oxygenation is determined by both bulk blood flow and the efficiency of oxygen extraction. Bulk blood flow is maintained during hypercapnia through increased sympathetic activity. The effect of hypercapnia on oxygen extraction, however, is unknown. This study evaluates the effect of hypercapnia on cells' capacity to adapt to reductions in oxygen availability by increasing oxygen extraction.
  
  
  METHODS
  In three groups of paralyzed, mechanically ventilated dogs that were anesthetized with alpha-chloralose, the concentration of carbon dioxide in the inhaled gas mixture was adjusted to achieve normocapnia, moderate hypercapnia (Paco2 = 72 +/- 3 [SE] mmHg) or severe hypercapnia (Paco2 = 118 +/- 4 [SE] mmHg). Stepwise hemorrhage was induced until each dog's blood pressure was destabilized. At each stage in the hemorrhage protocol, the oxygen delivery, oxygen consumption, and oxygen extraction ratios (ratio of arteriovenous oxygen content difference to arterial oxygen content) were determined.
  
  
  RESULTS
  At the point of onset of delivery dependence of oxygen consumption, the oxygen delivery rate (critical oxygen delivery) was 7.8 +/- 1.5 (SE) ml.kg-1.min-1 and the oxygen extraction ratio (critical oxygen extraction ratio) was 0.72 +/- 0.04 (SE) in the normocapnic dogs. Moderate hypercapnia had no effect on these parameters. In the severely hypercapnic dogs, the critical values for oxygen delivery and extraction ratios were 12.5 +/- 1.8 (SE) ml.kg-1.min-1 and 0.54 +/- 0.035 (SE), respectively (P < 0.05 for differences from the normocapnic dogs).
  
  
  CONCLUSIONS
  The results identify a previously unrecognized threat to tissue oxygenation and emphasize the importance of ensuring adequate oxygen delivery when adopting mechanical ventilatory strategies that permit respiratory acidosis to develop.
authors.affiliation: Division of Critical Care, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada.
authors.forename: M E
authors.initials: ME
authors.lastname: Ward
mesh_terms: D000142:Acidosis, Respiratory / Q000150:complications / Q000209:etiology / Q000378:metabolism*; D000222:Adaptation, Physiological; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D006801:Humans; D006935:Hypercapnia / Q000150:complications / Q000209:etiology / Q000378:metabolism; D010101:Oxygen Consumption / Q000502:physiology*; D012121:Respiration, Artificial / Q000009:adverse effects / Q000379:methods; D012771:Shock, Hemorrhagic / Q000150:complications / Q000378:metabolism*