title: Premenopause-dependent changes.
abstract: The authors retrospectively evaluated 1,773 climacteric outpatients in order to establish: (a) criteria able to distinguish different conditions in the transitional phase before menopause (advanced fertile age and premenopause) and (b) premenopause-related changes during the transition from one to the other of several clinical and laboratory parameters. Results showed an increase in gonadotropin plasma levels, a decrease in estrogen plasma levels and a greater frequency of women complaining of hot flushes in premenopause compared to advanced fertile age, as an expression of the progressive decline of ovarian function. Premenopause-related changes were a decrease in thyroid function and an increase in the body mass index, the beginning of bone loss, an increase in glucose, total cholesterol and triglyceride serum levels and a greater frequency of women complaining of hypertension and urinary stress incontinence. An increase in total proteins, uric acid and aminotransferase serum levels was also noted.
authors.affiliation: Department of Obstetrics and Gynecology, University of Bologna, Italy.
authors.forename: D
authors.initials: D
authors.lastname: de Aloysio
authors.forename: P
authors.initials: P
authors.lastname: Altieri
authors.forename: P
authors.initials: P
authors.lastname: Penacchioni
authors.forename: M
authors.initials: M
authors.lastname: Mauloni
authors.forename: F
authors.initials: F
authors.lastname: Bottiglioni
mesh_terms: D000328:Adult; D000375:Aging / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D001842:Bone and Bones / Q000378:metabolism; D002979:Climacteric / Q000502:physiology; D015331:Cohort Studies; D004573:Electrolytes / Q000097:blood / Q000652:urine; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D050356:Lipid Metabolism; D008875:Middle Aged; D017697:Premenopause / Q000502:physiology*; D012189:Retrospective Studies; D013963:Thyroid Hormones / Q000097:blood; D014550:Urinary Incontinence, Stress / Q000503:physiopathology
chemical_list: D001786:Blood Glucose; D004573:Electrolytes; D012739:Gonadal Steroid Hormones; D006065:Gonadotropins, Pituitary; D013963:Thyroid Hormones