Theophylline intoxication: clinical features and pharmacokinetics during treatment with charcoal hemoperfusion.
We describe a 50-year-old depressive patient with severe theophylline toxicity that occurred as a result of attempted suicide. Her theophylline levels peaked at 148 mg/l. She was promptly treated with charcoal hemoperfusion, and responded well. We describe the pharmacokinetics of theophylline removal via hemoperfusion, and review the literature.
Shechter
P
P
Department of Nephrology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Berkenstat
H
H
Segal
E
E
Rapoport
J
J
D002606:Charcoal; D003866:Depressive Disorder / Q000523:psychology; D016903:Drug Monitoring; D005260:Female; D006464:Hemoperfusion / Q000379:methods; D006801:Humans; D008875:Middle Aged; D011041:Poisoning / Q000628:therapy; D013406:Suicide, Attempted; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D013997:Time Factors
D002606:Charcoal; D013806:Theophylline