title: Effects of low-dose gamma-irradiation to the chest regions on the blood pressure of spontaneous hypertensive rats.
abstract: We examined changes in the blood pressure and the superoxide dismutase (SOD) activities in aortic tissue after gamma-irradiation to the chest regions of spontaneous hypertensive rats (SHR) and Wistar Kyoto rats (WKY), and obtained the following results. After 5 Gy irradiation, there was no change with time in the blood pressure in WKY rats, while a transient decrease (3 days later) was observed in SHR rats. The Cu/Zn-SOD activity in the aorta of SHR was less than that of WKY. 5 Gy irradiation induced an increase in the Cu/Zn-SOD activity in SHR nearly to the level observed in WKY, which remained unchanged upon irradiation. Therefore, unlike high-dose irradiation, irradiation at a relatively low-dose of 5 Gy to SHR appears to increase the aortic Cu/Zn-SOD activity, which is lacking in SHR, leading to a decrease in the blood pressure.
authors.affiliation: Radiation Safety Group, Central Research Institute of Electric Power Industry, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamaoka
authors.forename: K
authors.initials: K
authors.lastname: Ishii
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000201:enzymology / Q000528:radiation effects; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology / Q000528:radiation effects*; D005720:Gamma Rays; D006973:Hypertension / Q000201:enzymology / Q000503:physiopathology*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000201:enzymology / Q000528:radiation effects; D011829:Radiation Dosage; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013482:Superoxide Dismutase / Q000378:metabolism / Q000528:radiation effects
chemical_list: D013482:Superoxide Dismutase