title: 5-year follow-up of patients successfully transplanted after immunoadsorption to remove anti-HLA antibodies.
abstract: The function of renal allografts in patients who had received pretransplant immunoadsorption in order to remove cytotoxic anti-HLA antibodies was studied. We reviewed 6 patients who received a graft which functioned beyond 3 months; the mean follow-up period was 76 (range 62-89) months. Two grafts have been lost from chronic rejection, at 12 and 62 months, respectively. The mean plasma creatinine levels at 1 and 5 years were 169 (range 143-211) mumol/l and 155 (range 92-235) mumol/l, respectively (1.91, range 1.62-2.39, mg/dl and 1.75, range 1.04-2.66 mg/dl, respectively). The major source of morbidity during long-term follow-up has been the occurrence of renal artery stenosis in 5 patient and renal vein stenosis in 1. In conclusion, the 5-year graft survival and function was good in patients who received immunoadsorption and whose grafts survived beyond the first 3 months after transplantation.
authors.affiliation: Department of Medicine, King's College School of Medicine and Dentistry, London, UK.
authors.forename: R M
authors.initials: RM
authors.lastname: Higgins
authors.forename: D J
authors.initials: DJ
authors.lastname: Bevan
authors.forename: R W
authors.initials: RW
authors.lastname: Vaughan
authors.forename: A O
authors.initials: AO
authors.lastname: Phillips
authors.forename: S
authors.initials: S
authors.lastname: Snowden
authors.forename: M
authors.initials: M
authors.lastname: Bewick
authors.forename: J E
authors.initials: JE
authors.lastname: Scoble
authors.forename: B M
authors.initials: BM
authors.lastname: Hendry
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001157:Arterial Occlusive Diseases / Q000150:complications; D001323:Autoantibodies / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007164:Immunosorbents / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic / Q000276:immunology* / Q000401:mortality / Q000601:surgery; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012077:Renal Artery / Q000473:pathology; D012082:Renal Veins / Q000473:pathology; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D006680:HLA Antigens; D007164:Immunosorbents