Adenohypophyseal ascorbic acid: influences of oestradiol and methylene blue.
The ascorbic acid (AA) concentration in anterior pituitary and blood plasma was measured by the Roe-Kuether method in control rats and rats treated with oestradiol benzoate alone, methylene blue alone and with both oestradiol and methylene blue. We have found that methylene blue alone caused a significant drop in hypophyseal both AA and plasma AA concentrations. Methylene blue treatment prevented the increase in plasma AA concentration in oestradiol benzoate-treated rats.
Haluzík
M
M
Third Medical Department, Charles University, Prague, Czech Republic.
Nedvídková
J
J
Schreiber
V
V
D000818:Animals; D001205:Ascorbic Acid / Q000037:antagonists & inhibitors / Q000097:blood / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology*; D008297:Male; D008751:Methylene Blue / Q000494:pharmacology*; D009994:Osmolar Concentration; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D004958:Estradiol; D001205:Ascorbic Acid; D008751:Methylene Blue