Acute mesenteric ischaemia associated with 5-FU, cisplatin and vincristine chemotherapy.
We report a patient with acute superior mesenteric ischaemia following the use of cisplatin, 5-fluorouracil and vincristine combination chemotherapy. From a review of the literature, the possible mechanisms of acute vascular toxicity following chemotherapy are discussed.
Allerton
R
R
Norfolk and Norwich Hospital, Norwich, UK.
D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D003106:Colon / Q000098:blood supply; D004386:Duodenum / Q000098:blood supply; D017809:Fatal Outcome; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007511:Ischemia / Q000139:chemically induced*; D007583:Jejunum / Q000098:blood supply; D008297:Male; D017538:Mesenteric Artery, Superior / Q000187:drug effects*; D008875:Middle Aged; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects*
D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine; D002945:Cisplatin; D005472:Fluorouracil