Superovulation and intrauterine insemination vs. superovulation alone in the treatment of unexplained infertility. A randomized study.
OBJECTIVE
To assess whether intrauterine insemination (IUI) improves the fertility rates in women with unexplained infertility.


METHODS
We recruited 68 women with unexplained infertility and allocated them randomly to treatment with three to five cycles of superovulation plus IUI (36 patients) or superovulation alone (32 patients). Superovulation was obtained with clomiphene citrate, human menopausal gonadotropins and human chorionic gonadotropins.


RESULTS
The cycle fecundity rate was 10% in patients who underwent superovulation alone and 19% in those treated with superovulation plus IUI (P < .05).


CONCLUSIONS
Our results demonstrate that superovulation plus IUI is more effective than superovulation alone in the treatment of unexplained infertility.
Arcaini
L
L
VIIth Department of Obstetrics and Gynecology, L Sacco Hospital, Milan, Italy.
Bianchi
S
S
Baglioni
A
A
Marchini
M
M
Tozzi
L
L
Fedele
L
L
D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D002996:Clomiphene / Q000627:therapeutic use; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D007315:Insemination, Artificial / Q000379:methods*; D008596:Menotropins / Q000627:therapeutic use; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D013480:Superovulation
D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D002996:Clomiphene; D008596:Menotropins