Spermatotoxic effects of carbaryl in rats.
The spermatotoxic effect of carbaryl in adult and young male rats has been examined. Carbaryl 50 and 100 mg/kg b.wt. Male fed 5 d/week for 60 days, caused dose and age-dependent decline in epididymal sperm count and sperm motility, an increase in sperm with abnormal morphology. The dose of 25 mg/kg/d was a 'No observed effect level' for the indices studied. Young animals in comparison to adults exhibited pronounced spermatotoxic effects.
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Industrial Toxicology Research Centre, Lucknow, India.
Shankar
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Srivastava
S P
SP
D000284:Administration, Oral; D000375:Aging / Q000378:metabolism; D000818:Animals; D012721:Carbaryl / Q000008:administration & dosage / Q000633:toxicity*; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D051381:Rats; D013076:Sperm Count / Q000187:drug effects*; D013081:Sperm Motility / Q000187:drug effects*; D013094:Spermatozoa / Q000737:chemistry / Q000473:pathology*
D007306:Insecticides; D012721:Carbaryl