Ontogenetic development of the response to anandamide and delta 9-tetrahydrocannabinol in mice.
We studied the ontogenetic response to cannabinoid receptor ligands by measuring motor activity and analgesia in response to anandamide or delta 9-THC from day 6 of age. No response to anandamide was observed up to the age of weaning (day 23), while a nonsignificant response to delta 9-THC was observed starting between days 15 and 20. This is compatible with observations that children respond to the antiemetic effects of THC without psychotropic side effects.
Fride
E
E
Department of Natural Products, Hebrew University of Jerusalem, Faculty of Medicine, Israel.
Mechoulam
R
R
D000375:Aging / Q000502:physiology*; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D002186:Cannabinoids / Q000378:metabolism*; D013759:Dronabinol / Q000494:pharmacology*; D063388:Endocannabinoids; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects*; D010147:Pain Measurement / Q000187:drug effects; D053284:Polyunsaturated Alkamides
D018712:Analgesics, Non-Narcotic; D001095:Arachidonic Acids; D002186:Cannabinoids; D063388:Endocannabinoids; D053284:Polyunsaturated Alkamides; D013759:Dronabinol; C078814:anandamide