title: Platelets and coagulation. An update.
abstract: Accepted mechanisms of coagulation are being challenged as new proteins and feedback mechanisms are discovered and evaluated. These new proteins, including tissue factor pathway inhibitor, not only change the way we look at the coagulation mechanism, but also give us potential alternatives in treatment of hemophilia. Gene therapy continues to be a challenging research area, with hemophilia serving as the prototypic hereditary disease target. As acquired disorders of coagulation secondary to immune-mediated events are studied and better understood, our approaches to management of these cases will also change to the benefit of our patients.
authors.affiliation: Department of Pathobiology, College of Veterinary Medicine, Auburn University, Alabama, USA.
authors.forename: M K
authors.initials: MK
authors.lastname: Boudreaux
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000502:physiology*; D001792:Blood Platelets / Q000737:chemistry / Q000276:immunology / Q000502:physiology*; D004283:Dog Diseases / Q000097:blood / Q000503:physiopathology; D004285:Dogs; D006467:Hemophilia A / Q000097:blood / Q000503:physiopathology / Q000662:veterinary; D016023:Integrins / Q000032:analysis / Q000502:physiology; D013921:Thrombocytopenia / Q000097:blood / Q000503:physiopathology / Q000662:veterinary
chemical_list: D016023:Integrins