title: The effect of gestational age at birth on morbidity in patients with gastroschisis.
abstract: Infants born with gastroschisis frequently present with an eviscerated intestinal segment that is inflamed and thickened. The damaged segment of intestine displays absorption and motility disturbances for a variable period of time after gastroschisis repair. Clinical and animal research suggests that the damage to the eviscerated intestine is caused by prolonged exposure to amniotic fluid and/or progressive constriction on the intestine and its blood supply by the umbilical ring. Some obstetricians and pediatric surgeons have advocated early elective delivery to decrease the exposure of the bowel to these potentially damaging influences. Fifty-five patients underwent gastroschisis repair at the authors' institution during the last 6 years. Many of these patients had early elective delivery after their pulmonary maturity was judged adequate based on their amniotic lecithin/sphingomyelin ratios. The patients were divided into three groups according to gestational age at the time of delivery. Elective early delivery did not lessen the need for silo closure or hasten the time until enteral feeding could be tolerated. The hospital stay was not shortened for the early delivery group. This retrospective review supports the concept that patients with sonographically identified antenatal gastroschisis are best managed by delivery at full term.
authors.affiliation: University of Alabama School of Medicine, Children's Hospital of Alabama, Birmingham 35233, USA.
authors.forename: M
authors.initials: M
authors.lastname: Simmons
authors.forename: K E
authors.initials: KE
authors.lastname: Georgeson
mesh_terms: D000367:Age Factors; D005260:Female; D005769:Gastrointestinal Motility; D005865:Gestational Age; D006555:Hernia, Ventral / Q000150:complications* / Q000151:congenital* / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D007751:Labor, Induced; D008286:Malabsorption Syndromes / Q000209:etiology; D009017:Morbidity; D011247:Pregnancy; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D013997:Time Factors