Tribological and mycological consequences of the use of a miconazole nitrate-containing paste for the prevention of diaper dermatitis: an open pilot study.
The diaper environment increases the coefficient of skin friction and compromises the function of the stratum corneum. In this study, the tribological and mycological benefit of the use of a miconazole nitrate-containing paste on diapered skin was evaluated. A total of 135 instrumental measurements of both erythema and stratum corneum alterations were made on alternate days for 3 weeks in 15 infants. Biometrological parameters were the chromacity a* of the skin and the squamometry index. Cultures testing for Candida albicans were also performed. In the days following the use of the paste, the chromacity a*, the squamometry index and the number of positive cultures of C. albicans were significantly reduced compared to the same evaluations made off treatment.


CONCLUSIONS
Miconazole nitrate-containing paste reduces the tribological interference between cloth diapers and skin as well as providing the diapered skin with an improved microbial environment.
Piérard-Franchimont
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Department of Dermatopathology, CHU du Sart Tilman, Liège, Belgium.
Letawe
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Piérard
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D000935:Antifungal Agents / Q000627:therapeutic use*; D002175:Candida / Q000302:isolation & purification; D003124:Colorimetry; D003963:Diaper Rash / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control*; D004817:Epidermis / Q000473:pathology; D004890:Erythema / Q000473:pathology; D006801:Humans; D007223:Infant; D008825:Miconazole / Q000627:therapeutic use*; D009824:Ointments; D010865:Pilot Projects
D000935:Antifungal Agents; D009824:Ointments; D008825:Miconazole