The influence of aging on renal response to cadmium in Syrian hamsters.
To determine the renal effects of cadmium (Cd) in older animals, we administered subcutaneously a single dose of cadmium, 3.0 mg/kg/BW, to Syrian hamsters aged 16 wk ("young") and 60 wk ("old"). Marked morphologic changes in the kidney and renal dysfunction were observed, especially in the older animals. The concentration of MDA in the renal cortex was significantly increased only in young hamsters treated with cadmium. Concentrations of glutathione (GSH) in the renal cortex were increased in the old hamsters on d 6. Increased levels of renal MDA after cadmium treatment may induce the production of GSH in the kidney thus preventing renal damage. Aging can increase the susceptibility to the renal effects of cadmium.
Shibasaki
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Second Department of Internal medicine, Jikei University School of Medicine, Tokyo, Japan.
Xu
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QY
Ohno
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Ishimoto
F
F
Sakai
O
O
D000118:Acetylglucosaminidase / Q000652:urine; D000375:Aging / Q000473:pathology / Q000502:physiology*; D000818:Animals; D002104:Cadmium / Q000032:analysis; D019256:Cadmium Chloride / Q000008:administration & dosage / Q000633:toxicity*; D006224:Cricetinae; D005978:Glutathione / Q000032:analysis; D007279:Injections, Subcutaneous; D007672:Kidney Cortex / Q000737:chemistry / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D008647:Mesocricetus; D009929:Organ Size / Q000187:drug effects; D011507:Proteinuria / Q000139:chemically induced; D014556:Urine
D002104:Cadmium; D008315:Malondialdehyde; D000118:Acetylglucosaminidase; D005978:Glutathione; D019256:Cadmium Chloride