title: Ewing's sarcoma and peripheral primitive neuroectodermal tumor: an interim report.
abstract: The primitive neuroectoderm and its progeny seemingly give rise to an ever-increasing number of clinicopathologic entities. Ewing's sarcoma and peripheral primitive neuroectodermal tumor have recently been united by relatively unique antigens expressed by the MIC-2 gene, commonly coexpressed neural markers, and cytogenetic and molecular genetic abnormalities. Because of these factors, the current thinking is that Ewing's sarcoma and the peripheral primitive neuroectodermal tumor are parts of a phenotypic spectrum. We present an "interim report" on this group of neoplasms, emphasizing their presentation in the head and neck.
authors.affiliation: Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston, USA.
authors.forename: J G
authors.initials: JG
authors.lastname: Batsakis
authors.forename: B
authors.initials: B
authors.lastname: Mackay
authors.forename: A K
authors.initials: AK
authors.lastname: el-Naggar
mesh_terms: D005260:Female; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000473:pathology; D006801:Humans; D008297:Male; D018242:Neuroectodermal Tumors, Primitive / Q000235:genetics / Q000473:pathology; D012512:Sarcoma, Ewing / Q000235:genetics / Q000473:pathology