Inhibition of low density lipoprotein oxidation by myrigalone B, a naturally occurring flavonoid.
The influence of myrigalone B, a flavonoid from the fruit exudate of Myrica gale L. on Cu(2+)-induced oxidation of low density lipoprotein from cholesterol fed rabbits was investigated. Myrigalone B was an effective antioxidant, as shown by its ability to dose-dependently prolong the lag time for the formation of conjugated dienes. A 100% increase in lag time corresponds to a myrigalone B concentration of 1.4 +/- 1.1 microM. For alpha-tocopherol, used as a reference, this effect corresponds to a concentration of 1.9 +/- 1.2 microM. Myrigalone B also dose-dependently reduced the maximum rate of formation of conjugated dienes, 1.4 microM causing a 15 +/- 5% reduction, but it had no influence on the maximal amount of conjugated dienes formed.
Mathiesen
L
L
Department of Pharmacology, University of Oslo, Norway.
Malterud
K E
KE
Nenseter
M S
MS
Sund
R B
RB
D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D047188:Chalcones; D002784:Cholesterol / Q000008:administration & dosage; D005419:Flavonoids / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008077:Lipoproteins, LDL / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D011388:Prolactin / Q000187:drug effects / Q000378:metabolism; D011817:Rabbits
D000975:Antioxidants; D047188:Chalcones; D005419:Flavonoids; D008077:Lipoproteins, LDL; C100377:myrigalone B; D011388:Prolactin; D002784:Cholesterol