title: Synthesis of 4,17-diazasteroid inhibitors of human 5 alpha-reductase.
abstract: The synthesis of the 17-aza isomer of finasteride is described. With the side chain amide group of the compound existing in the Z configuration the structure is similar to one of the two favored conformations of finasteride. A series of 4,17-diazasteroids was assayed against the isoenzymes of human 5 alpha-reductase.
authors.affiliation: Institute of Chemistry, University of Warsaw, Białystok Branch, Poland.
authors.forename: J W
authors.initials: JW
authors.lastname: Morzycki
authors.forename: Z
authors.initials: Z
authors.lastname: Lotowski
authors.forename: A Z
authors.initials: AZ
authors.lastname: Wilczewska
authors.forename: J D
authors.initials: JD
authors.lastname: Stuart
mesh_terms: D058891:5-alpha Reductase Inhibitors; D002855:Chromatography, Thin Layer; D018120:Finasteride / Q000031:analogs & derivatives*; D006801:Humans; D007536:Isomerism; D008958:Models, Molecular
chemical_list: D058891:5-alpha Reductase Inhibitors; D018120:Finasteride