title: Effect of central acute administration of cadmium on drinking behavior.
abstract: The effect of acute third ventricle cadmium administration on the drinking behavior of adult male rats under different situations was studied. Injections of cadmium chloride (0.07, 0.7,and 7.0 ng/rat) significantly attenuated water intake in dehydrated rats. Drinking behavior induced by acute intracerebroventricular injections of carbachol (2 micrograms/rat) or angiotensin II (5 ng/rat) was also inhibited by central cadmium injections. Cadmium-induced blockade in water intake in dehydrated animals was reverted by the previous administration of a 5-HT2 antagonist (RP62203) in different doses (5 and 10 micrograms/rat). The data clearly reveal that cadmium elicits very fast actions on the central nervous system. It is suggested that cadmium-induced attenuation of water intake may rely on at least three different mechanisms: impairment of cholinergic and angiotensinergic systems in the brain and stimulation of a central serotonergic drive acting on 5-HT2 receptors. The study of cadmium neurotoxicity by observation of drinking behavior, a behavioral parameter easy to be recorded and measured, is proposed.
authors.affiliation: Department of Physiology, Federal University of Bahia, Brazil.
authors.forename: E
authors.initials: E
authors.lastname: De Castro E Silva
authors.forename: H
authors.initials: H
authors.lastname: Ferreira
authors.forename: M
authors.initials: M
authors.lastname: Cunha
authors.forename: C
authors.initials: C
authors.lastname: Bulcão
authors.forename: C
authors.initials: C
authors.lastname: Sarmento
authors.forename: I
authors.initials: I
authors.lastname: De Oliveira
authors.forename: J B
authors.initials: JB
authors.lastname: Fregoneze
mesh_terms: D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D003499:Cyclic S-Oxides / Q000494:pharmacology; D004326:Drinking / Q000187:drug effects*; D004327:Drinking Behavior / Q000187:drug effects*; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012702:Serotonin Antagonists / Q000494:pharmacology; D013997:Time Factors
chemical_list: D003499:Cyclic S-Oxides; D009281:Naphthalenes; D012702:Serotonin Antagonists; D002104:Cadmium; C070475:fananserin