title: Outcome variables in presymptomatic individuals at higher risk of developing Alzheimer disease.
abstract: The treatment of individuals at risk of Alzheimer disease is feasible in well-designed, placebo-controlled, double-blind studies. The favored design would be life survival for cognitive impairment, alterations in instrumental ADL, and selected biological variables.
authors.affiliation: McGill Centre for Studies in Aging, Hôpital Sacré-Coeur de Montréal, Montreal, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Gauthier
authors.forename: J
authors.initials: J
authors.lastname: Montplaisir
authors.forename: D
authors.initials: D
authors.lastname: Petit
authors.forename: Y
authors.initials: Y
authors.lastname: Joanette
authors.forename: H
authors.initials: H
authors.lastname: Feldman
authors.forename: E
authors.initials: E
authors.lastname: Mohr
authors.forename: N P
authors.initials: NP
authors.lastname: Nair
authors.forename: J
authors.initials: J
authors.lastname: Poirier
mesh_terms: D000544:Alzheimer Disease / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D008991:Monitoring, Physiologic; D011379:Prognosis; D012307:Risk Factors