title: Farnesyltransferase inhibitors: a new class of cancer chemotherapeutics.
authors.affiliation: Department of Cancer Research, Merck Research Laboratories, West Point, PA 19486, USA.
authors.forename: K S
authors.initials: KS
authors.lastname: Koblan
authors.forename: N E
authors.initials: NE
authors.lastname: Kohl
authors.forename: C A
authors.initials: CA
authors.lastname: Omer
authors.forename: N J
authors.initials: NJ
authors.lastname: Anthony
authors.forename: M W
authors.initials: MW
authors.lastname: Conner
authors.forename: S J
authors.initials: SJ
authors.lastname: deSolms
authors.forename: T M
authors.initials: TM
authors.lastname: Williams
authors.forename: S L
authors.initials: SL
authors.lastname: Graham
authors.forename: G D
authors.initials: GD
authors.lastname: Hartman
authors.forename: A
authors.initials: A
authors.lastname: Oliff
authors.forename: J B
authors.initials: JB
authors.lastname: Gibbs
mesh_terms: D019883:Alkyl and Aryl Transferases; D000595:Amino Acid Sequence; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D051231:Farnesyltranstransferase; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology; D011487:Protein Conformation; D014166:Transferases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D018631:ras Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D009842:Oligopeptides; C094719:cysteinyl-valyl-tryptophyl-methionine; D014166:Transferases; D019883:Alkyl and Aryl Transferases; C083291:geranylgeranyltransferase type-I; C064911:p21(ras) farnesyl-protein transferase; D051231:Farnesyltranstransferase; D018631:ras Proteins