Outcome variables in presymptomatic individuals at higher risk of developing Alzheimer disease.
The treatment of individuals at risk of Alzheimer disease is feasible in well-designed, placebo-controlled, double-blind studies. The favored design would be life survival for cognitive impairment, alterations in instrumental ADL, and selected biological variables.
Gauthier
S
S
McGill Centre for Studies in Aging, Hôpital Sacré-Coeur de Montréal, Montreal, Canada.
Montplaisir
J
J
Petit
D
D
Joanette
Y
Y
Feldman
H
H
Mohr
E
E
Nair
N P
NP
Poirier
J
J
D000544:Alzheimer Disease / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D008991:Monitoring, Physiologic; D011379:Prognosis; D012307:Risk Factors