title: A randomized, blinded trial of uncooked cornstarch to diminish nocturnal hypoglycemia at diabetes camp.
abstract: OBJECTIVE
  To determine if uncooked cornstarch, as part of the evening snack, can avert nocturnal hypoglycemia in type 1 diabetes.
  
  
  METHODS
  Fifty-one campers and counselors at the American Diabetes Association Camp in San Bernardino, CA were randomly assigned to receive 5 g of uncooked cornstarch as part of the 21:00 evening snack vs. a standard snack of equivalent carbohydrate content. Each snack was given for five nights and the participants and medical personnel were blinded as to assignment. Midnight and 07:00 finger stick blood glucose levels were compared with values <60 mg/dl defined as hypoglycemia and values > 250 mg/dl defined as hyperglycemia.
  
  
  RESULTS
  There were 218 midnight and 222 07:00 values for comparison. There were six episodes of hypoglycemia at midnight and nine episodes of hypoglycemia at 07:00 for the cornstarch snack nights vs. 30 hypoglycemia episodes at midnight and 21 at 07:00 for the standard snack nights (P < 0.001 and <0.05, respectively). There was no difference in the number of hyperglycemic events at midnight or 07:00 for the cornstarch vs. standard snack nights. At midnight, 12% of campers had hypoglycemia after the cornstarch snack vs. 46% after the standard snack (P < 0.001), and at 07:00, 16% had hypoglycemia after cornstarch vs. 26% after the standard snack (P = 0.327).
  
  
  CONCLUSIONS
  These data suggest that uncooked cornstarch, as part of the evening snack, can diminish the nighttime and morning hypoglycemia associated with type 1 diabetes, without causing hyperglycemia.
authors.affiliation: Department of Pediatrics, Childrens Hospital Los Angeles, CA, USA.
authors.forename: F R
authors.initials: FR
authors.lastname: Kaufman
authors.forename: M
authors.initials: M
authors.lastname: Halvorson
authors.forename: N D
authors.initials: ND
authors.lastname: Kaufman
mesh_terms: D000293:Adolescent; D000328:Adult; D002940:Circadian Rhythm; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control*; D015994:Incidence; D008297:Male; D013213:Starch / Q000627:therapeutic use*
chemical_list: D013213:Starch