Molecular mediators of asthma: current insights.
With advances in molecular biology, the complex inflammatory events that underlie asthma are being unraveled. The players are diverse, involving two populations each of mast cells and helper T cells, eosinophils, bronchial endothelial and epithelial cells, and an array of vasoactive and bronchoactive mediators. The clinical message is already clear: Treat the inflammation early.
Krishna
M T
MT
University of Southampton, United Kingdom.
Chauhan
A J
AJ
Holgate
S T
ST
D001249:Asthma / Q000276:immunology* / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism / Q000502:physiology*; D016232:Endothelins / Q000502:physiology; D006801:Humans; D008407:Mast Cells / Q000145:classification / Q000502:physiology; D008967:Molecular Biology; D013601:T-Lymphocytes / Q000502:physiology*
D016207:Cytokines; D016232:Endothelins