Lithium transport in the chicken and marine teleost kidney.
The clearance ratio-C(Li)/C(ln) (Excretion Fraction of Lithium-EFLi) in the cod (Gadus morrhua L.) kidney amounts to 15.1 +/- 4.7, in the black sculpin (Myoxocephalus scorpius L.) kidney, to 6.88 +/- 1.22, which indicates secretion of lithium by the marine teleost kidney. A direct correlation has been found between EFLi and EFMg. Injection of furosemide (15 mg/kg B.W.) increase while injection of the 20% para-amino-hippurate solution (1.6 ml/kg B.W.) does not change EFLi in the cod kidney. Infusion of 10 mM LiNO3 in the 0.9% NaCl solution (3.5 ml/kg B.W.) into the chicken (Gallus domesticus L.) left v. saphena produces, owing to the lithium inflow into the renoportal system, a marked unilateral increase of the renal lithium excretion. Infusion of 10% NaCl solution (3.5 ml/kg B.W.) together with 10 mM LiNO3 into the chicken left v. saphena is accompanied by a more pronounced ipsilateral increase of the lithium excretion and EFLi. The data obtained indicate diversity of mechanisms (glomerular filtration, reabsorption and secretion) participating in the renal lithium excretion in the animals studied.
Natochin YuV
I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
Shakhmatova
E I
EI
D000818:Animals; D001692:Biological Transport; D002645:Chickens / Q000378:metabolism*; D004232:Diuretics / Q000494:pharmacology; D005399:Fishes / Q000378:metabolism*; D005665:Furosemide / Q000494:pharmacology; D007668:Kidney / Q000378:metabolism*; D008094:Lithium / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism / Q000652:urine; D011188:Potassium / Q000097:blood / Q000652:urine; D012964:Sodium / Q000097:blood / Q000652:urine; D013045:Species Specificity
D004232:Diuretics; D005665:Furosemide; D008094:Lithium; D012964:Sodium; D008274:Magnesium; D011188:Potassium