title: High-altitude pulmonary hypertension: effects of captopril on pulmonary and systemic arterial pressures.
abstract: The purpose of investigation was the assessment of the effect of captopril on both systemic (Pa) and pulmonary arterial pressures (PPA) in patients with high-altitude pulmonary hypertension (HAPH). Seventeen patients (mean age 44 +/- 6.8 years) with HAPH and mild-to-moderate systemic arterial hypertension were included in the study. All the patients underwent right heart catheterization with measurements of systolic PPA (PPA,syst), mean PPA (PPA) and diastolic PPA (PPA,diast). After a 4 week placebo phase, patients with PPA,syst > 25 mm Hg, PPA > 15 mm Hg and systemic diastolic blood pressure (Pa,diast) > 100 mm Hg received captopril (50-75 mg at 08.00) for a period of 12 weeks. The statistical evaluation of the results were made using the Student's t-test. It was found that captopril significantly decreases PPA and Pa.
authors.affiliation: Cukurova University, Balcali Hospital, Department of Cardiology, Adana, Turkey.
authors.forename: Z A
authors.initials: ZA
authors.lastname: Niazova
authors.forename: T A
authors.initials: TA
authors.lastname: Batyraliev
authors.forename: K S
authors.initials: KS
authors.lastname: Aikimbaev
authors.forename: G Z
authors.initials: GZ
authors.lastname: Kudaiberdieva
authors.forename: F
authors.initials: F
authors.lastname: Akgul
authors.forename: Y K
authors.initials: YK
authors.lastname: Soodanbekova
authors.forename: A
authors.initials: A
authors.lastname: Birand
mesh_terms: D000328:Adult; D000531:Altitude; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000627:therapeutic use*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D008875:Middle Aged; D011652:Pulmonary Circulation / Q000187:drug effects*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002216:Captopril