title: Hormonal replacement and lipid changes in postmenopausal women.
abstract: To assess the effect of hormonal replacement therapy on lipid changes, measurement of serum total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), apolipoprotein A-1 (Apo-A) and apolipoprotein B (Apo-B) was performed on 93 postmenopausal women. Women in the study group (HRT) (51/93) received estrogen with or without progestin. The control group (Non-HRT) (42/93) did not receive any hormone regimen. The measurement was done at 0, 6 and 12 months. The results revealed that triglyceride increased significantly more in the non-HRT than the HRT group at 6 and 12 months. (Non-HRT: +21.7%, +21.7%; HRT: -2.8%, +2.4%, respectively P < 0.05). However, there was no significant difference in changes of other lipid profiles between the two groups at 6 and 12 months (Non-HRT: TC -2.7%, +0.7%, HDL +2.9%, +5.1%, LDL -5.2%, -4.1%, Apo-A +0.5%, +0.9%, Apo-B +3.8%, +1.3%: HRT: TC -1.4%, -2.8%, HDL +4.7%, +6.2%, LDL -1.5%, -4.9%, Apo-A -0.9%, +1.6%, Apo-B -2.6%, -1.6%, respectively P > 0.05). The paradoxical changes of triglyceride and HDL might partly be explained by the effect of progestins used in this study.
authors.affiliation: Department of Obstetrics and Gynecology, Chulalongkorn University, Bangkok, Thailand.
authors.forename: K
authors.initials: K
authors.lastname: Limpaphayom
authors.forename: N
authors.initials: N
authors.lastname: Taechakraichana
authors.forename: U
authors.initials: U
authors.lastname: Jaisamrarn
mesh_terms: D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000032:analysis / Q000187:drug effects*; D008875:Middle Aged; D017698:Postmenopause / Q000187:drug effects*; D011372:Progestins / Q000627:therapeutic use; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D004967:Estrogens; D008074:Lipoproteins; D011372:Progestins