An experimental study on the neurotolerability of gadobenate dimeglumine in a rat model of focal brain ischemia.
OBJECTIVE
The neurologic safety of the new magnetic resonance imaging contrast agent gadobenate dimeglumine has been assessed in rats suffering from localized blood-brain barrier damage.


METHODS
The adopted experimental model was the photochemically induced brain ischemia in the rat. Flash-evoked visual potentials were recorded simultaneously from the damaged area and from the corresponding contralateral position in conscious rats before and after the administration of the contrast medium.


RESULTS
The intravenous administration of 0.9 mmol/kg of gadobenate dimeglumine did not induce any significant changes in the visual responses recorded from the ischemic side compared with the intact side. Rats treated with saline or with the reference compounds gadopentetate dimeglumine (Magnevist) and gadoteridol (ProHance) gave comparable results.


CONCLUSIONS
The results are in favor of the use of gadobenate dimeglumine in patients suffering from a localized damage to blood-brain barrier.
La Noce
A
A
Milano Research Centre, Bracco SpA, Italy.
Miragoli
L
L
Samuelli
G
G
Tirone
P
P
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000187:drug effects*; D002545:Brain Ischemia / Q000503:physiopathology*; D003287:Contrast Media; D004338:Drug Combinations; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D005682:Gadolinium / Q000633:toxicity*; D019786:Gadolinium DTPA; D006571:Heterocyclic Compounds / Q000633:toxicity; D008279:Magnetic Resonance Imaging; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives* / Q000633:toxicity; D009942:Organometallic Compounds / Q000633:toxicity*; D004369:Pentetic Acid / Q000031:analogs & derivatives / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley
D003287:Contrast Media; D004338:Drug Combinations; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; C064572:gadobenic acid; D008536:Meglumine; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA