Selective gamma-chain T-cell receptor gene rearrangements in a patient with Omenn's syndrome: absence of V-II subgroup (V gamma 9) transcripts.
Only gamma-chain T-cell receptor transcripts utilizing V-1 subgroup gene segments were found in peripheral blood lymphocytes from a patient with Omenn's syndrome. gamma-Chain T-cell receptor transcripts utilizing the V gamma 9 (V-II subgroup) gene segment were absent in peripheral blood lymphocytes from this patient. V gamma 9 J gamma 1.2 C gamma 1 rearrangements are those primarily found in peripheral blood lymphocytes (70 to 85%) from normal donors.
Mathioudakis
G
G
Department of Immunology, M. D. Anderson Cancer Center, University of Texas, Houston, USA.
Good
R A
RA
Chernajovsky
Y
Y
Day
N K
NK
Platsoucas
C D
CD
D004802:Eosinophilia / Q000235:genetics; D015329:Gene Rearrangement, T-Lymphocyte / Q000235:genetics*; D054747:Histiocytic Sarcoma / Q000235:genetics; D006801:Humans; D007223:Infant; D008206:Lymphatic Diseases / Q000235:genetics; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics* / Q000302:isolation & purification; D016511:Severe Combined Immunodeficiency / Q000235:genetics* / Q000276:immunology*
D016692:Receptors, Antigen, T-Cell, gamma-delta