Indoxyl-beta-D-glucuronide and 3-indoxyl sulfate in plasma of hemodialysis patients.
The content of indoxyl-beta-D-glucuronide, which has been found in patients' plasma as a new indicator of renal failure, logarithmically correlated with that of 3-indoxyl sulfate (indican) in the plasma of hemodialysis patients, showing another weak correlation with beta(2)-microglobulin content. The content ratio of indoxyl-beta-D-glucuronide to 3-indoxyl sulfate (IG/IS) gradually increased depending on the duration of hemodialysis treatment. Indoxyl-beta-D-glucuronide could be easily dialyzed in the hemodialysis treatment, in contrast to hardly dialyzable 3-indoxyl sulfate which bound to plasma proteins. Therefore, glucuronide conjugation in indole excretion is favorable for hemodialysis patients in that it eliminates indoxyl compounds in blood by hemodialysis.
Agatsuma
S
S
Kojinkai Hospital, Miyagi, Japan.
Sekino
H
H
Watanabe
H
H
D002851:Chromatography, High Pressure Liquid; D005260:Female; D005470:Fluorometry; D005965:Glucuronates / Q000097:blood*; D006801:Humans; D007200:Indican / Q000097:blood*; D007211:Indoles / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D001613:beta 2-Microglobulin / Q000032:analysis
D005965:Glucuronates; D007211:Indoles; D001613:beta 2-Microglobulin; C059836:indoxyl glucuronide; D007200:Indican