[Surgical case of cerebral pilocytic astrocytoma--clinicopathologic study and analysis of proliferation potential by PCNA staining].
The clinical and the pathological features of a surgical case of adult pilocytic astrocytoma in the right temporal lobe are described. The growth kinetics of the tumor cells were investigated by immunohistochemical staining of Proliferating cell nuclear antigen (PCNA). The patient, a 23-year-old man, was admitted to our hospital with a history of loss of consciousness. A CT scan showed a cystic lesion with enhanced mural nodule in the right temporal lobe. Total resection of the mural nodule including the surrounding cyst wall was performed. Histopathological examination revealed tumor cells exhibiting a biphasic pattern with capillary proliferation and some Rosenthal fibers. Only 8.7% of the tumor cells were PCNA-positive. Pilocytic astrocytoma of the cerebrum is a clearly recognizable, distinctive entity with a natural history and pathological features similar to those of the relatively benign cerebellar astrocytoma of childhood. Standardized assessment of PCNA in pilocytic astrocytomas of the cerebrum may be useful as an independent indicator of biological behavior.
Nakayama
Y
Y
Department of Neurosurgery, Fukuoka University, Japan.
Tanaka
A
A
Kumate
S
S
Yoshinaga
S
S
Nonaka
M
M
D000328:Adult; D001254:Astrocytoma / Q000473:pathology / Q000601:surgery*; D001932:Brain Neoplasms / Q000473:pathology / Q000601:surgery*; D002455:Cell Division; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*
D018809:Proliferating Cell Nuclear Antigen