[Effect of glucocorticoids on activity of soluble and membrane-bound forms of carboxypeptidase H in vivo].
Inhibition of soluble and membrane-bound carboxypeptidase H in rat hypothalamus, striatum and pituitary gland by hydrocortisone and dexamethasone treatment in vivo has been established. Differences in the dynamics of change in the activity were determined by the action of hydrocortisone and dexamethasone. Differences of the dynamics of change in soluble and membrane-bound carboxypeptidase H activity were also observed. Possible causes of these differences are discussed.
Vernigora
A N
AN
Nikishin
N N
NN
Gengin
M T
MT
D000595:Amino Acid Sequence; D000818:Animals; D043423:Carboxypeptidase H; D002268:Carboxypeptidases / Q000378:metabolism*; D002462:Cell Membrane / Q000201:enzymology; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology; D003907:Dexamethasone / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects / Q000201:enzymology; D008969:Molecular Sequence Data; D010902:Pituitary Gland / Q000187:drug effects / Q000201:enzymology; D051381:Rats
D003907:Dexamethasone; D002268:Carboxypeptidases; D043423:Carboxypeptidase H; D006854:Hydrocortisone