title: Surgery and polychemotherapy of non-functional endocrine pancreatic tumors: a case report with a dramatic clinical response.
abstract: Endocrine pancreatic tumors (EPT) are a rare clinical entity, representing 5% of all pancreatic tumors. Nonfunctional subtypes (NF-EPT) often present themselves at diagnosis in a locally advanced or metastatic stage. Therapeutic planning of these neoplasias is based on a multidisciplinary integration of surgery and medical treatments. The Authors describe a case of NF-EPT with massive metastatic spread after cytoreductive surgery, with impressive response to polychemotherapy with 5-fluorouracil, epirubicin and dacarbazine. The various options concerning chemotherapic treatment of these tumors are reviewed.
authors.affiliation: Dept. of Endocrine Surgery, University of Catania, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Piazza
authors.forename: F
authors.initials: F
authors.lastname: Ferraù
authors.forename: G
authors.initials: G
authors.lastname: Lavenia
authors.forename: A
authors.initials: A
authors.lastname: Managò
authors.forename: F
authors.initials: F
authors.lastname: Fraggetta
authors.forename: M A
authors.initials: MA
authors.lastname: Cannizzaro
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007515:Islets of Langerhans; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D012074:Remission Induction / Q000379:methods; D014057:Tomography, X-Ray Computed