[Contribution of hematopoietic growth factors and especially in the context of grafts of hematopoietic stem cells].
The growth factor of hematopoiesis, G-CSF and GM-CSF, are now extremely useful in stem cell transplantation (SCT). Their main indications are given in this short paper. They accelerate hematopoietic recovery and they reduce morbidity and mortality after autologous SCT. GM-CSF can protect from hematopoietic toxicity of Gancyclovir and can reduce the mortality related to autologous and allogeneic graft failure. The combination of GM-CSF, G-CSF and erythropoietin can replace autologous SCT after a high dose therapy. G and GM-CSF are used to mobilise peripheral stem cells and allow peripheral blood stem cell transplantation. G-CSF given after a chemotherapy is able to mobilise Philadelphia negative stem cells in chronic myelocytic leukemia patients. Finally allogeneic peripheral blood stem cell mobilised by G-CSF in healthy donor is now a new field of clinical trials.
Fouillard
L
L
Service d'Hématologie, CHU Saint-Antoine, Paris.
D004359:Drug Therapy, Combination; D004921:Erythropoietin / Q000008:administration & dosage; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000008:administration & dosage*; D006410:Hematopoiesis / Q000502:physiology; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D011184:Postoperative Period
D004921:Erythropoietin; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor