Methamphetamine stimulates the release of neuropeptide Y and noradrenaline from the paraventricular nucleus in rats.
Effects of methamphetamine (MAP) on the extracellular neuropeptide Y (NPY) and noradrenaline (NA) levels were examined in the vicinity of the paraventricular nucleus (PVN) of freely moving rats by means of push-pull perfusion. The NA and NPY levels increased significantly in 30-60 min and reached the maximum level in 90-120 min after intraperitoneal administration of MAP. The effects were dose-dependent. The maximum levels were 1.6-fold of the pretreatment level for NPY and 7-fold for NA, respectively, when 5.0 mg/kg b.w. of methamphetamine was administered. It is concluded that MAP stimulates the releases of paraventricular NPY and NA, but the effect is more strong for NA than for NPY.
Yoshihara
T
T
Department of Physiology, Hokkaido University School of Medicine, Sapporo, Japan.
Honma
S
S
Mitome
M
M
Honma
K
K
D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D009478:Neuropeptide Y / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D009478:Neuropeptide Y; D008694:Methamphetamine; D009638:Norepinephrine