Insulin-like growth factor binding proteins (IGFBPs): physiological and clinical implications.
Insulin-like growth factors (IGF-I and IGF-II) play an essential role in cell proliferation and differentiation, via both endocrine and paracrine or autocrine mechanisms. In biological media, IGF-I and IGF-II are reversibly associated with specific, high-affinity binding proteins. (IGFBP-1 to -6) whose expression varies with tissue of origin, stage of development, and hormonal and nutritional status. They have diverse functions in IGF transport, in delivery of the IGFs to their target cells and in modulating the IGFs' interactions with their receptors.
Binoux
M
M
Institut National de la Santé et de la Recherche Médicale, Unité de Recherches sur la Régulation de la Croissance (U. 142), Hôpital Saint Antoine, Paris, France.
D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007335:Insulin-Like Growth Factor II / Q000378:metabolism
D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II