Dopamine DRD2/Cys311 is not associated with chronic schizophrenia.
A mutation in the DRD2 receptor gene has been reported in association with schizophrenia in Japanese and Caucasian populations. The variation, Ser to Cys at codon 311, occurs in the third intracellular loop of the receptor and is therefore putatively functional. We report the results of screening US Caucasian schizophrenic and nonschizophrenic populations. We detected the occurrence of the DRD2 Cys311 variant in both schizophrenics and controls. Our data demonstrates no significant difference between the frequency of Cys311 in Caucasian schizophrenic and non-schizophrenic populations, indicating no association with schizophrenia.
Crawford
F
F
Roskamp Laboratories, University of South Florida, Tampa 33613, USA.
Hoyne
J
J
Cai
X
X
Osborne
A
A
Poston
D
D
Zaglul
J
J
Dajani
N
N
Walsh
S
S
Bradley
R
R
Solomon
R
R
Mullan
M
M
D044466:Asian People; D001483:Base Sequence; D003062:Codon; D003545:Cysteine; D017931:DNA Primers; D005787:Gene Frequency; D014644:Genetic Variation; D006801:Humans; D007564:Japan / Q000208:ethnology; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D012694:Serine; D014481:United States; D044465:White People
D003062:Codon; D017931:DNA Primers; D017448:Receptors, Dopamine D2; D012694:Serine; D003545:Cysteine