Transformation and recovery of rat skeletal muscles in pathologic hormonal states.
There are numerous controversial data published on muscle transformation in pathologic endocrine states. Information is consistent in respect of slow muscle sensitivity to diabetes, but data concerning characteristics of fast muscles are contradictory under the same conditions. Sensitivity of fast and slow muscles to diabetes was examined and compared in this study. Diabetes was induced by a single intravenous dose of Streptozotocin in Wistar rats. Contractile parameters of soleus and extensor digitorum longus muscle were determined by in vitro measurements. We collected data on reversibility of diabetic transformation using exogenous thyroxine and insulin treatment. Insulin was used both to prevent and revert diabetic transformations. We found that, according to the data previously published, soleus muscle is more sensitive to diabetes than the extensor digitorum longus (EDL). Changes in the EDL muscle proved not to be statistically significant, but the comparison of hyperthyroid and diabetic muscles to controls led us to the conclusion that there is a sublimital transformation in the EDL in diabetes. T4 and insulin were effective in preventing diabetic muscle transformation. Application of insulin not only prevented diabetic complications, but its use in animals suffering from diabetes for a longer time (8 weeks) resulted in a successful recovery of the muscle transformation.
Bányász
T
T
Department of Physiology of University Medical School of Debrecen, Hungary.
Vér
A
A
Kovács
T
T
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004195:Disease Models, Animal; D005260:Female; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D013974:Thyroxine / Q000494:pharmacology*
D007328:Insulin; D013974:Thyroxine