title: Mechanistic and morphological origins of ultra-high molecular weight polyethylene wear debris in total joint replacement prostheses.
abstract: The mechanistic and morphological origins of microscopic wear debris generated from UHMWPE articular surfaces in total joint replacement prostheses are investigated in this study. It was found experimentally that the molecular chain structure at the articulating surface of UHMWPE undergoes a re-organization process due to strain accumulation caused by surface traction. This molecular re-organization process creates a fibre-like surface texture that exhibits an anisotropic behaviour similar to a unidirectionally reinforced polymer composite. This composite responds to stresses favourably if loaded along the fibre axis but unfavourably if loaded off axis. Due to the very complex multi-axial motion/loading nature at the articular surfaces in total joint replacements, the stress tensors applied to each localized asperity contact area continuously change their directions and magnitudes. These changes in the localized stress field create an off-axis loading situation at each localized contact zone with respect to the orientation of the molecular chains. Depending on the off-axis angle, failure of the molecular structure occurs in three different ways: tensile rupture at very small off-axis angles, shear rupture at intermediate off-axis angles and transverse splitting at large off-axis angles. These failure mechanisms all produce similar fibre-like wear debris. However, the failure stresses differ significantly among the three modes. According to this molecular wear theory, the preferred polymer microstructure for optimal wear resistance would be a three-dimensionally strong network connected by covalent bonds between molecular chains. For UHMWPE, a three-dimensional molecular network can be created by radiation induced cross-linking. Experiments conducted on both gamma irradiated and unirradiated UHMWPE specimens using a linear wear machine and multi-axial joint simulators confirmed the validity of the molecular wear theory.
authors.affiliation: Howmedica Incorporated, Division of Pfizer Hospital Products Group, Rutherford, New Jersey, USA.
authors.forename: A
authors.initials: A
authors.lastname: Wang
authors.forename: C
authors.initials: C
authors.lastname: Stark
authors.forename: J H
authors.initials: JH
authors.lastname: Dumbleton
mesh_terms: D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D006621:Hip Joint / Q000502:physiology; D006801:Humans; D007595:Joint Prosthesis; D007719:Knee Joint / Q000502:physiology; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D008954:Models, Biological; D008970:Molecular Weight; D011095:Polyethylenes / Q000737:chemistry; D011474:Prosthesis Design; D011475:Prosthesis Failure; D013314:Stress, Mechanical; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D011095:Polyethylenes