Two new bioactive diterpenes from Lepista sordida.
In a screening for inducers of the differentiation of human leukaemic cells, two new active diterpenoids were isolated from fermentations of the basidiomycete Lepista sordida. The structural elucidation by spectroscopic methods and the biological activities of both metabolites are described.
Mazur
X
X
Lehrbereich Biotechnologie der Universität Kaiserslautern, Germany.
Becker
U
U
Anke
T
T
Sterner
O
O
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D001487:Basidiomycota; D002454:Cell Differentiation / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D018922:HL-60 Cells; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse; D015394:Molecular Structure; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes