title: Monoclonal antibody affinities of structurally related modified nucleosides.
abstract: A scale of relative affinities of a series of 2'-deoxycytidine and cytidine (CD) derivatives was established based on the data of cross-reactivities of these compounds as well as the displacements obtained from a competitive ELISA. No correlation could be established between the nucleosides modifying structures and the affinities. This can be explained by the possibilities of the modifying structures of intra- and intermolecular nonimmunospecific interactions owing to their degree of functionalization.
authors.affiliation: Molecular Biology Department, National Center for Scientific Research, Havana, Cuba.
authors.forename: D
authors.initials: D
authors.lastname: Higginson-Clarke
authors.forename: R
authors.initials: R
authors.lastname: Guevara García
authors.forename: C
authors.initials: C
authors.lastname: Rodríguez Tanty
authors.forename: A
authors.initials: A
authors.lastname: López Brauet
authors.forename: L
authors.initials: L
authors.lastname: López-Canovas
authors.forename: A M
authors.initials: AM
authors.lastname: Riverón Rojas
authors.forename: A
authors.initials: A
authors.lastname: Macías Cabrera
mesh_terms: D000911:Antibodies, Monoclonal; D000915:Antibody Affinity; D003562:Cytidine / Q000031:analogs & derivatives* / Q000032:analysis / Q000276:immunology*; D004247:DNA / Q000032:analysis*; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000032:analysis / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D013329:Structure-Activity Relationship
chemical_list: D000911:Antibodies, Monoclonal; D003841:Deoxycytidine; D003562:Cytidine; D004247:DNA