Sarcoidosis mimicking toxoplasmosis with severe hypercalcaemia and normal 1,25-dihydroxy vitamin D.
We report a case of a female patient with sarcoidosis who presented with a generalized lymphadenopathy and a strong IgG serological test of toxoplasmosis. Progressive lymphadenopathy with a rising plasma calcium (up to 15 mg dL-1) with a normal plasma 1,25-dihydroxy vitamin D concentration occurred later. Corticosteroid therapy resulted in prompt clinical and biochemical responses with normalization of plasma calcium and a significant reduction in 1,25-dihydroxy vitamin D concentration. This is an exceptional presentation of sarcoidosis with severe hypercalcaemia and normal vitamin D metabolites.
Levy
Y
Y
Department of Internal Medicine, Rambam Medical Center, Technion, Israel.
Hayek
T
T
Finkelstein
R
R
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000150:complications*; D008206:Lymphatic Diseases / Q000209:etiology; D012507:Sarcoidosis / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D014123:Toxoplasmosis / Q000175:diagnosis*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D