title: Correlation of in vivo infectivity of hepatitis C virus to in vitro infectivity and to virion properties.
abstract: Serum from an individual who was chronically infected with hepatitis C virus (HCV) was inoculated into chimpanzees and a human T cell line. The serum contained a quasispecies population of HCV consisting of at least six genetic sequences. However, only two sequences (the same two sequences) were recovered both in chimpanzees and in cultured human T cell line, indicating that infection of the culture system reflects infection in vivo.
authors.affiliation: Department of Bacteriology, School of Medicine, University of Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yoshikura
authors.forename: M
authors.initials: M
authors.lastname: Hijikata
authors.forename: N
authors.initials: N
authors.lastname: Nakajima
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.forename: K
authors.initials: K
authors.lastname: Mizuno
authors.forename: T
authors.initials: T
authors.lastname: Rikihisa
authors.forename: T
authors.initials: T
authors.lastname: Ueno
authors.forename: S
authors.initials: S
authors.lastname: Nishimura
authors.forename: Y
authors.initials: Y
authors.lastname: Shimizu
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D016174:Hepacivirus / Q000472:pathogenicity*; D006801:Humans; D008969:Molecular Sequence Data; D002679:Pan troglodytes; D014771:Virion / Q000472:pathogenicity*; D014779:Virus Replication