Antioxidant properties of the decarboxylated dimer of aminoethylcysteine ketimine.
The decarboxylated dimer of aminoethylcysteine ketimine has been investigated for a possible general protective effect against oxyradical damage. It has been found that the dimer protects brain microsomes against lipid peroxidation induced by NADPH in the presence of Fe(III)-ADP chelate or by cumene hydroperoxide. The compound also inhibits lipid peroxidation stimulated by L-dopa and related compounds in the presence of Fe(III)-ADP complex. Furthermore the dimer is able to protect deoxyribose against hydroxyl radical induced degradation. These observations suggest that the dimer is a lipid peroxidation protective agent and a free radical scavenger.
Pecci
L
L
Dipartimento di Scienze Biochimiche A. Rossi Fanelli, Università di Roma La Sapienza, Italy.
Montefoschi
G
G
Antonucci
A
A
Cavallini
D
D
D000244:Adenosine Diphosphate / Q000737:chemistry; D000603:Amino Acids, Sulfur / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology; D002417:Cattle; D066298:In Vitro Techniques; D007501:Iron / Q000737:chemistry; D007980:Levodopa / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects; D008081:Liposomes; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism; D009249:NADP / Q000737:chemistry; D010084:Oxidation-Reduction
D000603:Amino Acids, Sulfur; D000975:Antioxidants; D008081:Liposomes; D007980:Levodopa; D009249:NADP; D000244:Adenosine Diphosphate; C035497:thialysine ketimine; D007501:Iron