title: Neuroprotective effect of TTC-909, an isocarbacyclin methyl ester incorporated in lipid microspheres, on hippocampal delayed neuronal death of stroke-prone spontaneously hypertensive rats.
abstract: TTC-909 is a newly developed isocarbacyclin methyl ester (TEI-9090) incorporated in lipid microspheres. The neuroprotective effect of TTC-909 was histologically examined in the pyramidal cell layer of the hippocampus CA1 subfield 7 days after transient forebrain ischemia using stroke-prone spontaneously hypertensive rats. TTC-909, given intravenously 10 min after the transient forebrain ischemia, dose-dependently protected against ischemia-related delayed neuronal death. The blood pressure remained unchanged following TTC-909 administration. This finding suggests that TTC-909 has a neuroprotective action on ischemic delayed neuronal death in the hippocampus.
authors.affiliation: Department of Pharmacology, Nagasaki University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamashita
authors.forename: Y
authors.initials: Y
authors.lastname: Kataoka
authors.forename: M N
authors.initials: MN
authors.lastname: Nakashima
authors.forename: Y S
authors.initials: YS
authors.lastname: Yamashita
authors.forename: H
authors.initials: H
authors.lastname: Tanabe
authors.forename: H
authors.initials: H
authors.lastname: Araki
authors.forename: M
authors.initials: M
authors.lastname: Niwa
authors.forename: K
authors.initials: K
authors.lastname: Taniyama
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002545:Brain Ischemia; D002452:Cell Count / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects*; D008297:Male; D008863:Microspheres; D009474:Neurons / Q000473:pathology; D018696:Neuroprotective Agents; D017966:Pyramidal Cells / Q000166:cytology / Q000187:drug effects; D051381:Rats; D011918:Rats, Inbred SHR
chemical_list: D018696:Neuroprotective Agents; C068518:TTC 909; D011464:Epoprostenol