title: 5-Hydroxyindoleacetic acid (5-HIAA) and cortisol excretion as predictors of chemotherapy-induced emesis.
abstract: This study evaluated the relationship between prechemotherapy cortisol and 5-hydroxyindoleacetic acid (5-HIAA) excretion and chemotherapy-induced emesis. The urinary excretion of cortisol and the serotonin metabolite 5-HIAA in the night before chemotherapy administration were measured in 28 and 49 female patients receiving > 300 mg m-2 carboplatin. Vomiting and nausea were documented over a 3 day observation period. Lower basal cortisol excretion was significantly correlated with vomiting with or without nausea occurring within the observation period. 5-HIAA showed only a weak correlation with emesis on days 1-3, but low 5-HIAA excretion was correlated with a higher proportion of patients vomiting on days 2-3 following chemotherapy. Low basal cortisol excretion might be useful as a predictor for chemotherapy-induced emesis and therefore should be evaluated prospectively in future studies.
authors.affiliation: Department of Gynaecology, St Vincentius Hospitals, Karlsruhe, Germany.
authors.forename: A
authors.initials: A
authors.lastname: du Bois
authors.forename: W
authors.initials: W
authors.lastname: Vach
authors.forename: U
authors.initials: U
authors.lastname: Wechsel
authors.forename: R
authors.initials: R
authors.lastname: Holy
authors.forename: W
authors.initials: W
authors.lastname: Schaefer
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D015415:Biomarkers / Q000652:urine; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000652:urine*; D006897:Hydroxyindoleacetic Acid / Q000652:urine*; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced* / Q000652:urine; D014839:Vomiting / Q000139:chemically induced* / Q000652:urine
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D006897:Hydroxyindoleacetic Acid; D006854:Hydrocortisone