title: Regulation of the onset of meiosis in the developing testis.
abstract: Meiotic division begins the process of spermatogenic maturation leading to sperm formation. In contrast to the ovary, in which meiosis is initiated early in development, onset of meiosis in the testis is delayed until the time of puberty. An assay procedure was utilized to evaluate factors responsible for the activation and prevention of meiosis in the developing rabbit testis. Testicular specimens from postnatal rabbits at different ages were used to determine if meiosis-activating substance (MAS) activity and meiosis-preventing substance (MPS) activity could be demonstrated prior to the onset of spermatogenesis. An in vitro system in which undifferentiated gonads from 11.5 day old mouse fetuses are cultured in test and control media was employed. The findings indicate that MAS activity is associated with the onset of spermatogenesis and is also present shortly after birth. Activity of MPS is present throughout much of the prespermatogenic period, with a decline to reach low levels at the onset of spermatogenesis.
authors.affiliation: Sansum Medical Research Foundation, Santa Barbara, CA 93105, USA.
authors.forename: B
authors.initials: B
authors.lastname: Gondos
authors.forename: A G
authors.initials: AG
authors.lastname: Byskov
authors.forename: J L
authors.initials: JL
authors.lastname: Hansen
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004622:Embryo, Mammalian / Q000378:metabolism; D005314:Embryonic and Fetal Development; D008297:Male; D008540:Meiosis / Q000502:physiology; D051379:Mice / Q000196:embryology; D011817:Rabbits; D013737:Testis / Q000196:embryology* / Q000254:growth & development* / Q000378:metabolism