Clinical manifestations and treatment of mycobacterium avium-intracellulare complex infection in HIV-infected patients.
Disseminated infection caused by Mycobacterium avium-intracellulare complex is a common late opportunistic infection in HIV-infected patients. The clinical manifestations are non-specific, with fever, respiratory and gastrointestinal tract symptoms and weight loss. Blood culture is an easy and safe way of diagnosing the infection. Treatment can reduce symptoms and probably increase the quality of life and survival. An optimal treatment regimen is not established and has to be identified in comparative studies. According to the available data, the first line of drugs is ethambutol, clarithromycin or rifabutin and the second amikacin, clofazimin, azitromycin. Combination therapy must contain at least two or three drugs.
Julander
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Department of Infectious Diseases, Huddinge Hospital, Sweden.
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D000995:Antitubercular Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D015270:Mycobacterium avium-intracellulare Infection / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D011379:Prognosis; D013548:Sweden
D000995:Antitubercular Agents