title: Effect of glucan immunomodulator on the immune response and larval burdens in mice with experimental toxocarosis.
abstract: Glucan immunomodulator, combined with immunoglobulin and zinc (GI), was tested in mice infected with Toxocara canis for its effects on the immune response and parasite recovery. Infection with 2 500 T. canis eggs per mouse induced a short-term depression of the proliferative response of T cells to phytohemaglutinin from Day 35 to a Day 49 post infection (p.i.). GI given in two doses at the start of the experiment markedly stimulated and restored cell proliferation at Days 21-63 p.i. Infection resulted in significant increase in specific circulating antibody level at Days 21 and 35 p.i. A striking reduction in the number of T. canis larvae, after GI administration was observed in the muscles of the GI-treated mice, compared with the untreated animals.
authors.affiliation: Parasitological Institute (SAS), Kosice, Slovak Republic.
authors.forename: J
authors.initials: J
authors.lastname: Soltys
authors.forename: Z
authors.initials: Z
authors.lastname: Borosková
authors.forename: P
authors.initials: P
authors.lastname: Dubinský
authors.forename: O
authors.initials: O
authors.lastname: Tomasovicová
authors.forename: H
authors.initials: H
authors.lastname: Auer
authors.forename: H
authors.initials: H
authors.lastname: Aspöck
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood / Q000187:drug effects; D001402:B-Lymphocytes / Q000187:drug effects*; D001921:Brain / Q000469:parasitology; D005936:Glucans / Q000494:pharmacology*; D007136:Immunoglobulins / Q000494:pharmacology; D007814:Larva / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D017166:Toxocara canis / Q000187:drug effects / Q000276:immunology; D014120:Toxocariasis / Q000188:drug therapy / Q000276:immunology*; D015032:Zinc / Q000494:pharmacology
chemical_list: D000276:Adjuvants, Immunologic; D000909:Antibodies, Helminth; D005936:Glucans; D007136:Immunoglobulins; D015032:Zinc