'Quality of life' after therapy in rats with myocardial infarction: dissociation between hemodynamic and behavioral improvement.
Rats with myocardial infarction provide a clinically relevant model for hemodynamic and survival studies. Moreover, behavioral changes in this model, i.e. increased anxiety and reduced interest in environment and social interactions, mimic aspects of the reduced quality of life of patients. In the present study, we investigated whether pharmacological treatment that is known to improve hemodynamics and prognosis could also affect the behavioral changes associated with quality of life. Rats with 3-week-old infarcts were treated with intermittent dobutamine (1 mg/kg i.p., twice daily) or captopril (2 milligrams in drinking water). After 2 weeks of treatment, when from previous studies hemodynamics are expected to be restored, behavioral tests were performed. In the free exploration test, which primarily evaluates exploratory behavior, dobutamine normalized the reduced interest in the environment. In the standard open field and social interaction tests, which also include an anxiety component, the beneficial effects of dobutamine were not observed. In contrast, captopril normalized all behavioral changes that indicated increased anxiety. In conclusion, the expected similar hemodynamic improvement with dobutamine and captopril treatment resulted in improvement of different aspects of the changed behavior of rats with myocardial infarction, indicating that there is no direct relationship between hemodynamics and quality of life. The behavioral tests used, in combination with our previously described functional hemodynamic measurements, could provide a new basis for evaluating the effects of therapy on hemodynamic function as well as the quality of life.
Schoemaker
R G
RG
Department of Pharmacology, Erasmus University Rotterdam, Netherlands.
Kalkman
E A
EA
Smits
J F
JF
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002216:Captopril / Q000627:therapeutic use; D004280:Dobutamine / Q000627:therapeutic use; D005106:Exploratory Behavior / Q000187:drug effects; D006120:Grooming / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology*; D011788:Quality of Life; D051381:Rats; D017208:Rats, Wistar
D004280:Dobutamine; D002216:Captopril