Lymphoproliferative disorders in Sotos syndrome: observation of two cases.
Sotos syndrome is included among the overgrowth disorders, most of which have an increased risk of neoplasms. Sotos syndrome does not appear to be related to a specific tumor type, but rather to the development of solid tumors of ectodermal or mesodermal origin in general. We report on two Sotos syndrome patients who developed a non-Hodgkin lymphoma and an acute lymphoblastic leukaemia, respectively. Our experience suggests that there may exist a high frequency of lymphoproliferative disorders in Sotos syndrome, and points out the importance of a long-term follow-up of Sotos syndrome patients, to detect a possible neoplastic evolution.
Corsello
G
G
Istituto Materno Infantile, Universita di Palermo, Italy.
Giuffrè
M
M
Carcione
A
A
Cuzto
M L
ML
Piccione
M
M
Ziino
O
O
D000015:Abnormalities, Multiple / Q000235:genetics*; D001921:Brain / Q000002:abnormalities; D002675:Child, Preschool; D006130:Growth Disorders / Q000150:complications / Q000235:genetics; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000150:complications*; D008297:Male; D012886:Skull / Q000002:abnormalities; D013577:Syndrome