Lithium blocks 45Ca2+ uptake into platelets in bipolar affective disorder and controls.
The basal uptake of radiolabelled 45Ca2+ into platelets and the effect of 1 mM lithium on uptake was measured in manic (n = 13) and depressed (n = 15) patients with bipolar disorder and in controls (n = 13). Lithium was significantly associated with inhibition of uptake of 45Ca2+ into platelets in all three groups. There were no significant intergroup differences in either basal levels of calcium uptake or the effects of lithium on calcium uptake (analysis of variance).
Berk
M
M
Department of Psychiatry, University of the Witwatersrand Medical School, Johannesburg, South Africa.
Kirchmann
N H
NH
Butkow
N
N
D000328:Adult; D001714:Bipolar Disorder / Q000097:blood* / Q000188:drug therapy; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D003866:Depressive Disorder / Q000097:blood; D005260:Female; D006801:Humans; D008094:Lithium / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales
D002132:Calcium Radioisotopes; D008094:Lithium; D002118:Calcium