title: Effect of galanin and enterostatin on sympathetic nerve activity to interscapular brown adipose tissue.
abstract: The effects of galanin and enterostatin on sympathetic activity have been examined in rats using electrophysiological techniques. Galanin, in doses of 25-300 pmol, and enterostatin, in doses of 0.5-10 nmol, were injected into the third ventricle of anesthetized male Sprague-Dawley rats in 1-microliter volumes. Galanin produced a dose-dependent suppression (ranging between 20 and 80%) of sympathetic firing rate of nerves innervating interscapular brown adipose tissue. In rats fed a chow diet, injection of enterostatin produced only a transient 10% rise in firing rate which returned to baseline within 10-15 min. In contrast, animals fed a high-fat diet showed a dose-dependent increase in firing rate lasting for 60 min. The results of this experiment are consistent with the hypothesis that food intake and sympathetic nervous system activity have a reciprocal relationship. The implications of this relationship are discussed.
authors.affiliation: Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA.
authors.forename: H
authors.initials: H
authors.lastname: Nagase
authors.forename: G A
authors.initials: GA
authors.lastname: Bray
authors.forename: D A
authors.initials: DA
authors.lastname: York
mesh_terms: D002001:Adipose Tissue, Brown / Q000294:innervation*; D000818:Animals; D001340:Autonomic Nerve Block; D003089:Colipases / Q000494:pharmacology*; D004041:Dietary Fats / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D004792:Enzyme Precursors; D019004:Galanin / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D011498:Protein Precursors / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology
chemical_list: D003089:Colipases; D004041:Dietary Fats; D004792:Enzyme Precursors; D011498:Protein Precursors; C037107:procolipase; D019004:Galanin