title: The mammalian cell cycle in normal and abnormal growth.
abstract: Cell division, a complex array of intracellular events, occurs in a highly ordered and carefully coordinated manner. This regulation is achieved by the sequential activation and deactivation of the members of a family of serine-threonine-specific protein kinases that consist of regulatory and enzymatic subunits, the cyclins and cyclin-dependent kinases. These enzymes, in turn, regulate the activity of other proteins involved in the mitogenic pathway. Mutations in the components of the regulatory pathways can lead to aberrant growth, including malignancies.
authors.affiliation: Department of Pediatrics, University of Rochester School of Medicine and Dentistry, New York, USA.
authors.forename: C C
authors.initials: CC
authors.lastname: Orlowski
authors.forename: R W
authors.initials: RW
authors.lastname: Furlanetto
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D018844:Cyclin-Dependent Kinases / Q000502:physiology; D016213:Cyclins / Q000502:physiology; D016193:G1 Phase / Q000502:physiology; D016195:G2 Phase / Q000502:physiology; D006128:Growth / Q000502:physiology*; D006130:Growth Disorders / Q000503:physiopathology*; D006801:Humans; D008938:Mitosis / Q000502:physiology; D016196:S Phase / Q000502:physiology
chemical_list: D016213:Cyclins; D018844:Cyclin-Dependent Kinases