title: Antibiotic susceptibility patterns of respiratory isolates of Klebsiella pneumoniae in Europe and the USA in 1992 and 1993. The Alexander Project Collaborative Group.
abstract: The overall antibiotic susceptibility of Klebsiella pneumoniae isolates collected in 1992 (n = 35) and 1993 (n = 85) was highly variable ranging from 0.8% for amoxycillin to 95.8% for ceftriaxone. On a weight for weight basis, the activity of the compounds decreased in the following sequence: ceftriaxone, cefixime, co-trimoxazole, ciprofloxacin, ofloxacin, cefaclor, amoxycillin/clavulanate, doxycycline, cefuroxime, chloramphenicol, amoxycillin. A small percentage of resistant strains was found for each of the compounds (between 0.8% for ceftriaxone and 12.5% for chloramphenicol) with the exception of amoxycillin which was almost uniformly resistant. There was a trend for the percentage of resistant strains to increase between the two study years for all compounds except for chloramphenicol. Resistance to beta-lactams in France and the USA is likely to have been due to strains producing extended spectrum beta-lactamases.
authors.affiliation: Max von Pettenkofer-Institut, Munich, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Bauernfeind
mesh_terms: D042462:4-Quinolones; D000658:Amoxicillin / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology; D002702:Chloramphenicol Resistance; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000494:pharmacology; D004318:Doxycycline / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D005060:Europe; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects*; D008826:Microbial Sensitivity Tests / Q000379:methods; D012141:Respiratory Tract Infections / Q000382:microbiology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology; D014481:United States
chemical_list: D042462:4-Quinolones; D000890:Anti-Infective Agents; D002511:Cephalosporins; D002969:Clavulanic Acids; D019818:Clavulanic Acid; D002701:Chloramphenicol; D000658:Amoxicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D004318:Doxycycline