title: Dopamine D2 receptor (DRD2) gene and susceptibility to posttraumatic stress disorder: a study and replication.
abstract: Subjects on an addiction treatment unit who had been exposed to severe combat conditions in Vietnam were screened for posttraumatic stress disorder (PTSD). Of 24 with PTSD, 58.3% carried the D2A1 allele. Of the remaining eight who did not meet PTSD criteria, 12.5% carried the D2A1 allele (p = 0.04). In a replication study of 13 with PTSD, 61.5% carried the D2A1 allele. Of the remaining 11 who did not meet criteria for PTSD, 0% carried the D2A1 allele (p = 0.002). For the combined group 59.5% of those with PTSD carried the D2A1 allele versus 5.3% of those who did not have PTSD (p = 0.0001). These results suggest that a DRD2 variant in linkage disequilibrium with the D2A1 allele confers an increased risk to PTSD, and the absence of the variant confers a relative resistance to PTSD.
authors.affiliation: Department of Human Genetics, City of Hope National Medical Center, Duarte, CA 91010-0269, USA.
authors.forename: D E
authors.initials: DE
authors.lastname: Comings
authors.forename: D
authors.initials: D
authors.lastname: Muhleman
authors.forename: R
authors.initials: R
authors.lastname: Gysin
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000235:genetics / Q000523:psychology; D000483:Alleles; D016000:Cluster Analysis; D003130:Combat Disorders / Q000523:psychology; D006580:Genetic Carrier Screening; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D017448:Receptors, Dopamine D2 / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors; D013313:Stress Disorders, Post-Traumatic / Q000235:genetics* / Q000378:metabolism; D019966:Substance-Related Disorders / Q000235:genetics / Q000523:psychology; D014481:United States; D014728:Veterans
chemical_list: D017448:Receptors, Dopamine D2