title: Structure and in vivo activity of hypoglycaemic analogues of human growth hormone (6-13).
abstract: A range of peptide analogues related to Asu11-human growth hormone (6-13) have been synthesized and tested for hypoglycaemic activity using in vivo insulin tolerance tests. Utilising an alanine scan procedure and a selective amino acid residue approach these structure-activity studies suggest that residues Phe10, Arg8 and the C-terminal beta-turn structure are important for the expression of biological activity.
authors.affiliation: Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.
authors.forename: P
authors.initials: P
authors.lastname: Thompson
authors.forename: N
authors.initials: N
authors.lastname: Lim
authors.forename: N J
authors.initials: NJ
authors.lastname: Ede
authors.forename: F M
authors.initials: FM
authors.lastname: Ng
authors.forename: I D
authors.initials: ID
authors.lastname: Rae
authors.forename: M T
authors.initials: MT
authors.lastname: Hearn
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D019382:Human Growth Hormone / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D010446:Peptide Fragments; D019382:Human Growth Hormone