Can insights into urodele limb regeneration be achieved with cell cultures and retroviruses?
Recent advances in the field of amphibian limb regeneration have provided insights into its cellular and molecular events. This review summarizes the development of cell lines from limb tissues and their application to the study of transdifferentiation and limb regeneration. In addition, the availability of suitable retroviral vectors for salamanders is discussed for it has opened new avenues for experimentation at the molecular level.
Tsonis
P A
PA
Department of Biology, University of Dayton 45469-2320, USA. tsonis@neelix.udayton.edu
Del Rio-Tsonis
K
K
Wallace
J L
JL
Burns
J C
JC
Hofmann
M C
MC
Millan
J L
JL
Washabaugh
C H
CH
D000818:Animals; D000957:Antigens, Viral, Tumor / Q000737:chemistry; D002478:Cells, Cultured; D005121:Extremities / Q000502:physiology*; D005434:Flow Cytometry; D018014:Gene Transfer Techniques; D017930:Genes, Reporter; D066298:In Vitro Techniques; D012038:Regeneration; D012190:Retroviridae; D012455:Salamandridae; D014162:Transfection; D014562:Caudata / Q000502:physiology*
D000957:Antigens, Viral, Tumor