[Pro-inflammatory cytokines: a pathogenic key of POEMS syndrome].
The Polyneuropathy, Organomegaly, Endocrinopathy, M protein, Skin changes (POMEMS) syndrome is a rare multisystem disorder of obscure pathogenesis, associated with osteosclerotic myeloma. Unlike multiple myeloma without neuropathy, circulating levels of proinflammatory cytokines (IL-1 beta, TNF-alpha IL-6) are increased in patients with POEMS syndrome. Sites of IL-1 beta production include lymph node and bone marrow tissues. These data support the view that pleiotropic effects of proinflammatory cytokines released secondary to a strong activation of the monocyte/macrophage system, take part in the multisystemic expression of the disease.
Gherardi
R K
RK
Group d'Etudes et de Recherche sur le Muscle et le Nerf, CHU Henri Mondor, Créteil, France.
Authier
F J
FJ
Belec
L
L
D016207:Cytokines / Q000502:physiology*; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D053583:Interleukin-1beta; D015850:Interleukin-6 / Q000097:blood; D015846:Monokines / Q000502:physiology; D009101:Multiple Myeloma / Q000097:blood; D016878:POEMS Syndrome / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D010446:Peptide Fragments / Q000097:blood; D011446:Prospective Studies; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors*; D018124:Receptors, Tumor Necrosis Factor / Q000037:antagonists & inhibitors; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D016207:Cytokines; D007375:Interleukin-1; D053583:Interleukin-1beta; D015850:Interleukin-6; D015846:Monokines; D010446:Peptide Fragments; D017472:Receptors, Interleukin-1; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; C052994:interleukin-1beta (163-171)