title: Natural history of vesicoureteral reflux in siblings.
abstract: OBJECTIVE
  We attempted to assess the natural course of vesicoureteral reflux after it was detected in asymptomatic siblings of children with reflux, and to determine predictors of and time to resolution.
  
  
  METHODS
  We reviewed the records and radionuclide cystograms of 76 girls and 32 boys 2 weeks to 103 months old (mean age 21 months) with vesicoureteral reflux detected in a sibling screening program. Predictors were determined using logistic regression and survival analysis.
  
  
  RESULTS
  Vesicoureteral reflux resolved in 52.8% of cases at a mean followup of 18.5 months. Yearly resolution rates exceeded 28%. Predictors of the likelihood of resolution were not identified. At diagnosis unilateral reflux and mild reflux were independent and univariate predictors, respectively, of more rapid resolution.
  
  
  CONCLUSIONS
  By showing that spontaneous resolution is likely for children with vesicoureteral reflux detected in a sibling screening program, this study supports nonsurgical management with annual imaging evaluation.
authors.affiliation: Department of Radiology (Division of Nuclear Medicine), Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: L P
authors.initials: LP
authors.lastname: Connolly
authors.forename: S T
authors.initials: ST
authors.lastname: Treves
authors.forename: D
authors.initials: D
authors.lastname: Zurakowski
authors.forename: S B
authors.initials: SB
authors.lastname: Bauer
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D012075:Remission, Spontaneous; D014718:Vesico-Ureteral Reflux / Q000175:diagnosis* / Q000235:genetics*