Synthesis and pharmacological properties of 2,4-disubstituted 5-amino-6-pyrimidinecarboxylic acid derivatives. Part III.
2,4-Disubstituted 5-amino-6-pyrimidinecarboxylic acid derivatives 5-13 were synthesized and evaluated for their pharmacological activity. Compounds 5, 7, 9, 10 and 12 showed antiaggressive effect, compounds 6 and 10 showed synergism with hexobarbital while compound 6 exerted analgesic activity.
Jasztold-Howorko
R
R
Department of Organic Chemistry, Medical Academy, Wrocław, Poland.
Machoń
Z
Z
Wilimowski
M
M
Wojewódzki
W
W
Barczyńska
J
J
Kedzierska
L
L
Orzechowska-Juzwenko
K
K
Duś
E
E
Dziewiszek
W
W
Rutkowska
M
M
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000374:Aggression / Q000187:drug effects; D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D018491:Dopamine Agonists / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D006591:Hexobarbital / Q000494:pharmacology; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010147:Pain Measurement / Q000187:drug effects; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D012110:Reserpine / Q000037:antagonists & inhibitors; D012890:Sleep / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects
D018712:Analgesics, Non-Narcotic; D002264:Carboxylic Acids; D018491:Dopamine Agonists; D006993:Hypnotics and Sedatives; D011619:Psychotropic Drugs; D011743:Pyrimidines; D012110:Reserpine; D006591:Hexobarbital; D006916:5-Hydroxytryptophan; D001058:Apomorphine