title: Tardive dyskinesia as a result of long-term prochlorperazine use.
abstract: Prochlorperazine is a centrally acting dopamine receptor antagonist that is most commonly used for the treatment of nausea and vomiting. Like many dopamine antagonists, prochlorperazine has the ability to induce extrapyramidal reactions in susceptible patients. Rarely, however, have cases of tardive dyskinesia been caused by the long-term use of this agent. We report the case of a patient who used prochlorperazine for a prolonged period and, during hospital admission, was found to have a new movement disorder. Alternative antiemetics that do not pose a risk of movement disorders, such as ondansetron and granisetron, are readily available and are efficacious.
authors.affiliation: Department of Psychiatry, Naval Medical Center, San Diego, Calif, USA.
authors.forename: V A
authors.initials: VA
authors.lastname: Alberts
authors.forename: G
authors.initials: G
authors.lastname: Catalano
authors.forename: M A
authors.initials: MA
authors.lastname: Poole
mesh_terms: D000932:Antiemetics / Q000009:adverse effects*; D018492:Dopamine Antagonists / Q000009:adverse effects*; D004409:Dyskinesia, Drug-Induced / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D017829:Granisetron / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D009325:Nausea / Q000188:drug therapy; D017294:Ondansetron / Q000627:therapeutic use; D011346:Prochlorperazine / Q000009:adverse effects*; D013997:Time Factors; D014839:Vomiting / Q000188:drug therapy
chemical_list: D000932:Antiemetics; D018492:Dopamine Antagonists; D017829:Granisetron; D017294:Ondansetron; D011346:Prochlorperazine