Immunohistochemical analysis of c-Fos and c-Jun in retinoblastoma.
The c-fos promoter is negatively regulated by the retinoblastoma (Rb)-susceptibility-gene-encoded protein as well as by other genes involved in the control of transcription, cell cycle regulation and neoplastic transformation. We have examined by immunohistochemistry the c-Fos and c-Jun proteins in five cases of retinoblastoma in order to evaluate eventual alterations in their expression in vivo, possibly related to a gene mutation or to loss of Rb negative control.
Faraldi
F
F
Istituto di Clinica Oculistica, Università degli Studi di Firenze, Italy.
Calzolari
A
A
Forni
M
M
Chiarelli
F
F
Mincione
F
F
Alfieri
G
G
D000818:Animals; D006801:Humans; D007124:Immunoenzyme Techniques; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism*; D011817:Rabbits; D012175:Retinoblastoma / Q000378:metabolism* / Q000473:pathology
D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun