title: Endothelial, haemostatic and haemorheological modifications in migraineurs.
abstract: Vasotropic, haemostatic and haemorheological parameters have been investigated in 17 patients suffering from migraine without aura in comparison with 11 sex and age matched healthy control subjects. NO metabolites (NO2- and NO3-), endothelin (ET-1), tissue plasminogen activator (tPA), plasminogen activator inhibitor (PAI-1), fibrinogen, D-dimer, fibrinopeptide A, beta thromboglobulin (beta-TG), blood viscosity, plasma viscosity, haematocrit (Htc) and red blood cell (RBC) filterability index (FI) were determined during headache free periods. Migraineurs NO3- and ET-1 plasma levels, compared to control values, showed a significant decrease and increase respectively; fibrinogen, beta-TG and D-dimer appeared slightly lowered in migraineurs, while Htc remained in the normal limits; tPA, PAI-1 and FI were significantly reduced, while fibrinopeptide A, blood viscosity and plasma viscosity at a low shear rate (shr) exhibited a significant rise. Data obtained support the involvement of endothelial, haemostatic and haemorheological functions in the pathogenesis of migraine.
authors.affiliation: II Chair of Pharmacology, Faculty of Medicine, University of Catania, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Bianchi
authors.forename: G
authors.initials: G
authors.lastname: Pitari
authors.forename: V
authors.initials: V
authors.lastname: Amenta
authors.forename: F
authors.initials: F
authors.lastname: Giuliano
authors.forename: M
authors.initials: M
authors.lastname: Gallina
authors.forename: R
authors.initials: R
authors.lastname: Costa
authors.forename: S
authors.initials: S
authors.lastname: Ferlito
mesh_terms: D000328:Adult; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000097:blood / Q000503:physiopathology*; D009569:Nitric Oxide / Q000097:blood*
chemical_list: D009569:Nitric Oxide