Oral pathoses caused by Candida albicans during chemotherapy: update on development mechanisms.
Oral candidiasis occurs at a high frequency among immunocompromised hosts. The development mechanisms of oral pathoses associated with Candida are complex and certainly multifactorial. In immunocompromised patients, they include the evolution of the buccal flora associated with the influence of antineoplastic treatments and immunosuppression. They also include adherence of Candida to epithelial cells of the oral cavity as a function of host cell-related and yeast-related factors. Interaction and cooperation between Candida and bacteria could be a third influence in the development of oral candidiasis. It seems important to determine these mechanisms more precisely so as to improve preventive and therapeutic measures.
Bunetel
L
L
Equipe de Biologie Buccale, UFR d'Odontologie, Rennes, France.
Bonnaure-Mallet
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001422:Bacterial Adhesion; D002176:Candida albicans / Q000502:physiology; D002180:Candidiasis, Oral / Q000276:immunology*; D017753:Ecosystem; D006801:Humans; D007121:Immunocompetence / Q000187:drug effects; D016867:Immunocompromised Host; D009061:Mouth Mucosa / Q000382:microbiology; D013291:Streptococcus / Q000502:physiology
D000970:Antineoplastic Agents