Immunohistochemical study of CA 19-9 and SPan-1 in cases of hydronephrosis.
Although the serum level of carbohydrate antigen (CA) 19-9 is reportedly increased in patients with hydronephrosis, virtually no immunohistochemical studies of this condition have been performed. Therefore, we examined immunohistochemically 11 hydronephrotic kidneys and 3 normal control kidneys using antibodies against CA 19-9 and SPan-1, another sialylated carbohydrate antigen. Immunoreactivity for CA 19-9 was seen in the transitional and tubular epithelia in most of the hydronephrotic kidneys (9 of the 11 cases), and also detected in 2 of the 3 control specimens, although there the distribution appeared to be limited. SPan-1 immunoreactivity showed the same trend. CA 19-9 and SPan-1 immunoreactivity in hydronephrosis appeared to be more widely distributed than in controls, although its mechanism remains unclear.
Inayama
Y
Y
Division of Anatomical and Surgical Pathology, Yokohama City University Hospital, Japan.
Uesato
M
M
Takase
K
K
Motono
N
N
Nakatani
Y
Y
Kitamura
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen / Q000032:analysis*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006869:Hydronephrosis / Q000378:metabolism*; D007150:Immunohistochemistry; D007668:Kidney / Q000378:metabolism; D008297:Male; D008875:Middle Aged
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; C059729:pancreatic associated antigen, SPan-1