A study of the optimum bacteriostatic action of a synthetic medicine on bacteria using a microcalorimetric method.
The growth thermograms of strain 6, 2b, 3b, 5b, 1a, x, and y of Shigella flexneri with the inhibitory action of a synthetic medicine were determined by using the 2277 thermal activity monitor. Using a microorganism growth model with inhibitory conditions, the specific growth rate (mu) at different concentrations (c) of a synthetic medicine were calculated and the mu approximately c equations were established. From these mu approximately c equations, the concentration of the synthetic medicine with which the specific growth rate was minimum could be calculated. Therefore, we can analyze the bacteriostatic action of the synthetic medicine on these bacteria.
Liu
Y
Y
Department of Chemistry, Qufu Normal University, China.
Nan
Z
Z
Sun
H
H
Zhang
H
H
Gao
P
P
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002151:Calorimetry / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D009942:Organometallic Compounds / Q000494:pharmacology; D012663:Semicarbazides / Q000494:pharmacology; D012763:Shigella flexneri / Q000187:drug effects*
D000900:Anti-Bacterial Agents; C103385:N-methyl-N-1,3,4-thiazole-salicylthiosemicarbazide-cobalt(II); D009942:Organometallic Compounds; D012663:Semicarbazides