Neuroimmunological findings in Guillain Barré syndrome, multiple sclerosis, and idiopathic polyneuropathies.
It is essential to know how the immune system acts in different neurological diseases, some of which are not very well known or are unknown. IgG and albumin were simultaneously quantified in serum and cerebrospinal fluid (CSF) of 47 patients with Guillain Barré Syndrome (GSB), 5 patients with multiple sclerosis (MS), and 14 patients with idiopathic polyneuropathies (IP). IgG local synthesis was observed in all patients, except in patients with IP. These patients showed a decrease in cerebrospinal fluid (CSF) flow.
Dorta-Contreras
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Neuroimmunology Lab, Hospital Pediátrico, San Miguel, Ciudad de La Habana, Cuba.
Silva-Somoza
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R
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D009422:Nervous System Diseases / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D011129:Polyradiculoneuropathy / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D012709:Serum Albumin / Q000134:cerebrospinal fluid / Q000378:metabolism
D007074:Immunoglobulin G; D012709:Serum Albumin