Assignment of genes encoding GABAA receptor subunits alpha 1, alpha 6, beta 2, and gamma 2 to a YAC contig of 5q33.
A gene cluster consisting of the four gamma-aminobutyric acidA (GABAA) receptor subunit genes GABRA1, GABRA6, GABRAB2, and GABRG2 was assigned to a yeast artificial chromosome (YAC) contig of 5q33. Two of the 26 YACs of the contig are positive for all four subunit genes. The order of the GABR subunit genes with respect to known anonymous gene loci is cen-D5S380 - D5S403 - D5S529 - GABRB2 - GABRA1/A6 - GABRG2-D 5S422-tel. This novel YAC contig lies between known YAC contigs of 5q34/q35 and 5q31-q33.
Kostrzewa
M
M
Institut für Humangenetik, Justus-Liebig-Universität Giessen, Germany.
Köhler
A
A
Eppelt
K
K
Hellam
L
L
Fairweather
N D
ND
Levy
E R
ER
Monaco
A P
AP
Müller
U
U
D002871:Chromosome Banding; D018244:Chromosomes, Artificial, Yeast; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D005810:Multigene Family; D011963:Receptors, GABA-A / Q000235:genetics*
D005819:Genetic Markers; D011963:Receptors, GABA-A