title: Bartter's syndrome: renal scintigraphic appearance after captopril administration.
abstract: We report a case of Bartter's syndrome, a rare disease characterized by hypokalemia, increased plasma renin and angiotensin II levels with normal blood pressure. During the diagnostic work-up, the patient had renal scintigraphy in baseline and after captopril administration. Pharmacological blockade of the renin-angiotensin system with captopril resulted in bilateral and symmetrical renal abnormalities (increase of parenchymal transit time, time to maximum activity and retained cortical activity, with cortical trapping of the radiopharmaceutical). Baseline scintigraphy was normal. The findings are consistent with Bartter's syndrome pathogenesis. Captopril renography may be useful to differentiate Bartter's syndrome from other covert causes of hypokalemia.
authors.affiliation: Nuclear Medicine Service, S. Orsola-Malpighi Policlinic Hospital, Bologna, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Dondi
authors.forename: S
authors.initials: S
authors.lastname: Fanti
authors.forename: N
authors.initials: N
authors.lastname: Monetti
mesh_terms: D000328:Adult; D000804:Angiotensin II / Q000097:blood; D002216:Captopril; D005260:Female; D006801:Humans; D007008:Hypokalemia / Q000209:etiology; D007668:Kidney / Q000000981:diagnostic imaging*; D007674:Kidney Diseases / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging*; D011866:Radioisotope Renography; D012083:Renin / Q000097:blood; D013577:Syndrome
chemical_list: D000804:Angiotensin II; D002216:Captopril; D012083:Renin