Fibrinolysis during normal pregnancy and severe preeclampsia relationships between plasma levels of plasminogen activators and inhibitors.
The antigen levels of plasminogen activator inhibitor type 1 (PAI-1), plasminogen activator inhibitor type 2 (PAI-2), tissue-type plasminogen activator (t-PA), and urokinase-type plasminogen activator (u-PA) were measured during pregnancy and severe preeclampsia. The PAI-1 and PAI-2 antigen levels increased linearly during pregnancy and promptly returned to the level of non-pregnant women after delivery. The t-PA and u-PA antigen levels increased slowly and linearly during pregnancy. In severe preeclampsia, the PAI-2 antigen level was lower than that observed during the 3rd trimester of normal pregnancy, and the t-PA antigen level was higher than that during the 3rd trimester of normal pregnancy. Immunohistochemical examination of placental tissue showed that the PAI-2 and u-PA antigens were localized in syncytiotrophoblasts. In severe preeclampsia, the PAI-2 and u-PA antigens in placental tissue did not stain as clearly as during the 3rd trimester of normal pregnancy. The PAI-2 and u-PA antigen levels showed a positive correlation with birth weight. Therefore, PAI-2 may be an important marker of placental function and abnormality in pregnancies.
Nakashima
A
A
Department of Obstetrics and Gynecology, Hamamatsu Medical Center, Shizuoka, Japan.
Kobayashi
T
T
Terao
T
T
D000911:Antibodies, Monoclonal / Q000276:immunology; D015415:Biomarkers; D001724:Birth Weight; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005342:Fibrinolysis / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D009929:Organ Size; D010920:Placenta / Q000033:anatomy & histology / Q000276:immunology / Q000502:physiology; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood* / Q000276:immunology; D017396:Plasminogen Activator Inhibitor 2 / Q000097:blood* / Q000276:immunology; D010960:Plasminogen Activators / Q000097:blood* / Q000276:immunology; D011225:Pre-Eclampsia / Q000097:blood* / Q000276:immunology; D011247:Pregnancy / Q000097:blood* / Q000276:immunology
D000911:Antibodies, Monoclonal; D015415:Biomarkers; D017395:Plasminogen Activator Inhibitor 1; D017396:Plasminogen Activator Inhibitor 2; D010960:Plasminogen Activators