Drug-related Henoch-Schönlein Purpura.
We report the case of a patient with Henoch-Schönlein Purpura related to a treatment with cefuroxime and diclofenac who presented important systemic manifestations including a glomerulonephritis with IgA mesangial deposits. Skin testing with beta lactam antibiotics and diclofenac were negative in immediate and late reaction as well as RAST test to penicillins G and V. No cautious administration of drugs was done because of the illness severity. Although a reaction to diclofenac could not be excluded we thought that the more probably implicated drug was cefuroxime because the patient referred a purpuric rash after the intake of cephradine for a mastitis, ten years ago.
Escudero
A
A
Division of Allergy, Rafael Méndez Hospital, Lorca, Spain.
Lucas
E
E
Vidal
J B
JB
Sánchez-Guerrero
I
I
Martínez
A
A
Illán
F
F
Ramos
J
J
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D002444:Cefuroxime / Q000008:administration & dosage / Q000009:adverse effects*; D002511:Cephalosporins / Q000008:administration & dosage / Q000009:adverse effects*; D004008:Diclofenac / Q000008:administration & dosage / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D006417:Hematuria / Q000139:chemically induced; D006801:Humans; D011695:IgA Vasculitis / Q000139:chemically induced*; D008413:Mastitis / Q000188:drug therapy; D011507:Proteinuria / Q000139:chemically induced
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002511:Cephalosporins; D004008:Diclofenac; D002444:Cefuroxime