title: The Microsponge Delivery System (MDS): a topical delivery system with reduced irritancy incorporating multiple triggering mechanisms for the release of actives.
abstract: The Microsponge Delivery System (MDS) is a unique technology for the controlled release of topical agents and consists of macroporous beads, typically 10-25 microns in diameter, loaded with active agent. When applied to the skin, the MDS releases its active ingredient on a time mode and also in response to other stimuli (rubbing, temperature, pH, etc). MDS technology is being used currently in cosmetics, over-the-counter (OTC) skin care, sunscreens and prescription products. By delivering the active gradually to the skin, MDS-benzoyl peroxide formulations, for example, have excellent efficacy with minimal irritation. These are typical benefits from the use of the MDS.
authors.affiliation: Embil Pharmaceutical Company Limited, Sisli, Istanbul, Turkey.
authors.forename: K
authors.initials: K
authors.lastname: Embil
authors.forename: S
authors.initials: S
authors.lastname: Nacht
mesh_terms: D000152:Acne Vulgaris / Q000628:therapy; D000818:Animals; D001585:Benzoyl Peroxide / Q000378:metabolism / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D007509:Irritants / Q000494:pharmacology; D007641:Keratolytic Agents / Q000494:pharmacology; D008610:Menthol / Q000378:metabolism; D008768:Methylmethacrylates / Q000378:metabolism; D051379:Mice; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D017137:Nonoxynol / Q000378:metabolism; D010539:Permeability; D011137:Polystyrenes / Q000378:metabolism; D011817:Rabbits; D012867:Skin / Q000378:metabolism; D013473:Sunscreening Agents / Q000378:metabolism; D014212:Tretinoin / Q000378:metabolism / Q000494:pharmacology; D014753:Vinyl Compounds / Q000378:metabolism
chemical_list: D004337:Drug Carriers; D007509:Irritants; D007641:Keratolytic Agents; D008768:Methylmethacrylates; D011137:Polystyrenes; D013473:Sunscreening Agents; D014753:Vinyl Compounds; D008610:Menthol; D017137:Nonoxynol; D014212:Tretinoin; C004985:divinyl benzene; D001585:Benzoyl Peroxide