title: Drug-related Henoch-Schönlein Purpura.
abstract: We report the case of a patient with Henoch-Schönlein Purpura related to a treatment with cefuroxime and diclofenac who presented important systemic manifestations including a glomerulonephritis with IgA mesangial deposits. Skin testing with beta lactam antibiotics and diclofenac were negative in immediate and late reaction as well as RAST test to penicillins G and V. No cautious administration of drugs was done because of the illness severity. Although a reaction to diclofenac could not be excluded we thought that the more probably implicated drug was cefuroxime because the patient referred a purpuric rash after the intake of cephradine for a mastitis, ten years ago.
authors.affiliation: Division of Allergy, Rafael Méndez Hospital, Lorca, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Escudero
authors.forename: E
authors.initials: E
authors.lastname: Lucas
authors.forename: J B
authors.initials: JB
authors.lastname: Vidal
authors.forename: I
authors.initials: I
authors.lastname: Sánchez-Guerrero
authors.forename: A
authors.initials: A
authors.lastname: Martínez
authors.forename: F
authors.initials: F
authors.lastname: Illán
authors.forename: J
authors.initials: J
authors.lastname: Ramos
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D002444:Cefuroxime / Q000008:administration & dosage / Q000009:adverse effects*; D002511:Cephalosporins / Q000008:administration & dosage / Q000009:adverse effects*; D004008:Diclofenac / Q000008:administration & dosage / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D006417:Hematuria / Q000139:chemically induced; D006801:Humans; D011695:IgA Vasculitis / Q000139:chemically induced*; D008413:Mastitis / Q000188:drug therapy; D011507:Proteinuria / Q000139:chemically induced
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002511:Cephalosporins; D004008:Diclofenac; D002444:Cefuroxime