title: Intra-amniotic Chlamydia trachomatis infection.
abstract: Chlamydia trachomatis is one of the most prevalent genital pathogens in pregnant women. Ascending, transcervical infection may reach fetal membranes creating chorioamnionitis or amniotic fluid infection. The aim of this study was to examine amniotic fluids obtained during cesarean section for the presence of chlamydial IgM- and IgG-specific antibodies, and for the presence of C. trachomatis antigen. Five of 52 (9.6%) amniotic fluid samples were seropositive. Two of 52 (3.8%) amniotic fluid samples had C. trachomatis antigen in the epithelial cells of the amnion. In conclusion, our data indicate that there is a high rate of transmission of C. trachomatis from mother to infant and that the pathogen can be identified in the amniotic fluid.
authors.affiliation: Institute of Microbiology and Immunology, School of Medicine, University of Belgrade, Yugoslavia.
authors.forename: S
authors.initials: S
authors.lastname: Djukić
authors.forename: M
authors.initials: M
authors.lastname: Nedeljković
authors.forename: M
authors.initials: M
authors.lastname: Pervulov
authors.forename: A
authors.initials: A
authors.lastname: Ljubić
authors.forename: N
authors.initials: N
authors.lastname: Radunović
authors.forename: B
authors.initials: B
authors.lastname: Lazarević
mesh_terms: D000293:Adolescent; D000328:Adult; D000653:Amniotic Fluid / Q000166:cytology / Q000276:immunology / Q000382:microbiology*; D000907:Antibodies, Bacterial / Q000032:analysis / Q000276:immunology; D000942:Antigens, Bacterial / Q000032:analysis / Q000276:immunology; D002584:Cervix Uteri / Q000276:immunology / Q000382:microbiology; D002690:Chlamydia Infections / Q000196:embryology / Q000382:microbiology* / Q000635:transmission; D002692:Chlamydia trachomatis / Q000276:immunology / Q000302:isolation & purification*; D005260:Female; D005312:Fetal Blood / Q000276:immunology / Q000382:microbiology*; D019084:Fluorescent Antibody Technique, Indirect; D005865:Gestational Age; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology; D007075:Immunoglobulin M / Q000032:analysis / Q000276:immunology; D018445:Infectious Disease Transmission, Vertical; D007752:Obstetric Labor, Premature / Q000382:microbiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology*; D011263:Pregnancy Trimester, Third; D011446:Prospective Studies
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M