title: Amniotic fluid index predicts the relief of variable decelerations after amnioinfusion bolus.
abstract: OBJECTIVE
  Our purpose was to determine whether intrapartum amniotic fluid index before amnioinfusion can be used to predict response to therapeutic amnioinfusion.
  
  
  METHODS
  Intrapartum patients (n = 85) with repetitive variable decelerations in fetal heart rate that necessitated amnioinfusion (10 ml/min for 60 minutes) underwent determination of amniotic fluid index before and after bolus amnioinfusion. The fetal heart tracing was scored (scorer blinded to amniotic fluid index values) for number and characteristics of variable decelerations before and 1 hour after initiation of amnioinfusion. The amnioinfusion was considered successful if it resulted in a decrease of > or = 50% in total number of variable decelerations or a decrease of > or = 50% in the rate of atypical or severe variable decelerations after administration of the bolus. Spontaneous vaginal births before completion of administration of the bolus (n = 18) were excluded from analysis. The probability of success of amnioinfusion in relation to amniotic fluid index was analyzed with the chi(2) test for progressive sequence.
  
  
  RESULTS
  The mean amniotic fluid index before amnioinfusion was 6.2 +/- 3.3 cm. An amniotic fluid index of < or = 5 cm was present in 40% of patients (27/67), and an amniotic fluid index of < or = 8 cm was present in 72% of patients (48/67). The probability of success of amnioinfusion decreased with increasing amniotic fluid index before amnioinfusion (76% [16/21] when initial amniotic fluid index was 0 to 4 cm, 63% [17/27] when initial amniotic fluid index was 4 to 8 cm, 44% [7/16] when initial amniotic fluid index was 8 to 12 cm, and 33% [1/3] when initial amniotic fluid index was > 12 cm, p = 0.03). The incidence of nuchal cords or true umbilical cord knots increased in relation to amniotic fluid index before amnioinfusion.
  
  
  CONCLUSIONS
  Amniotic fluid index before amnioinfusion can be used to predict the success of amnioinfusion for relief of variable decelerations in fetal heart rate. Failure of amnioinfusion at a high amniotic fluid index before amnioinfusion may be explained by the increased prevalence of nuchal cords or true knots in the umbilical cord.
authors.affiliation: Department of Obstetrics and Gynecology, Harbor-University of California, Los Angeles Medical Center, Torrance 90509, USA.
authors.forename: C Y
authors.initials: CY
authors.lastname: Spong
authors.forename: F
authors.initials: F
authors.lastname: McKindsey
authors.forename: M G
authors.initials: MG
authors.lastname: Ross
mesh_terms: D000328:Adult; D000650:Amnion; D000653:Amniotic Fluid / Q000502:physiology*; D005260:Female; D006340:Heart Rate, Fetal / Q000187:drug effects*; D006801:Humans; D007267:Injections; D007743:Labor, Obstetric; D011237:Predictive Value of Tests; D011247:Pregnancy; D012965:Sodium Chloride / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D012965:Sodium Chloride