Artificial liver support: the pipe dream of today should be the reality of the near future.
The title of this article is taken from an interesting Letter to the Editor entitled 'Artificial liver support-Pipe dream or reality' by Cattral and Levy of the Toronto Hospital, Canada, published in the New England Journal of Medicine 1994, in which the authors persuasively propose possibilities of artificial liver support and suggest its advantages. We find that their suggestions agree with the core of our thoughts on this subject. The present article deals with the concept of implanting livers taken from humans, primates or non-primates (e.g. hog) into patients in parallel with their own metabolically fatigued or cirrhotic livers, with minimal surgical manipulation, as a prelude to total artificial liver support via a liver dialysis device. While the possibility exists that the host liver may recover function, a donor liver, whether implanted into the patient's abdomen or connected in vitro to the patient's circulatory system extracorporeally, may provide the host liver respite and a period for recovery and proliferation, if possible. Once recovery is under way, the donor liver may be removed and the patient will not experience the usual risks of rejection and the necessary side-effects of immunosuppression associated with conventional full hepatectomy and donor transplantation. The viability of a liver implantation model in rats is correlated in this article with hepatic acute phase response.
Fouad
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FM
Biomedical Mass Spectrometry Unit, McGill University, Montreal, Quebec, Canada.
Mamer
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OA
Shahidi
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D000818:Animals; D005112:Extracorporeal Circulation; D006084:Graft Rejection; D006801:Humans; D008099:Liver / Q000502:physiology*; D016031:Liver Transplantation; D019164:Liver, Artificial; D051381:Rats; D014019:Tissue Donors / Q000600:supply & distribution