A detoxication route for acetaldehyde: metabolism of diacetyl, acetoin, and 2,3-butanediol in liver homogenate and perfused liver of rats.
The metabolism of diacetyl (2,3-butanedione), acetoin (3-hydroxy-2-butanone), and 2,3-butanediol, which are metabolites of acetaldehyde was quantitatively investigated using rat liver homogenate, liver perfusion, and in vivo experiments. Diacetyl and acetoin were reduced to 2,3-butanediol in these experiments, but acetoin and 2,3-butanediol were scarcely oxidized to diacetyl, indicating that the reduction reaction to 2,3-butanediol from diacetyl occurs actively in rat liver. The formation of acetoin from diacetyl required either NADH or NADPH as a reductant, while the reduction of acetoin to 2,3-butanediol required NADH. Acetoin and 2,3-butanediol were more readily accumulated than diacetyl in brain tissue.
Otsuka
M
M
Faculty of Pharmaceutical Sciences, Okayama University.
Mine
T
T
Ohuchi
K
K
Ohmori
S
S
D000079:Acetaldehyde / Q000493:pharmacokinetics*; D000093:Acetoin / Q000378:metabolism*; D000818:Animals; D002072:Butylene Glycols / Q000378:metabolism*; D003931:Diacetyl / Q000378:metabolism*; D005233:Fatty Alcohols / Q000378:metabolism; D008658:Inactivation, Metabolic; D008099:Liver / Q000378:metabolism*; D010477:Perfusion; D051381:Rats
D002072:Butylene Glycols; D005233:Fatty Alcohols; C026978:2,3-butylene glycol; C011159:acyloin; D000093:Acetoin; D000079:Acetaldehyde; D003931:Diacetyl