title: Effects of calcium channel antagonists on the reinforcing properties of morphine, ethanol and cocaine as measured by place conditioning.
abstract: Morphine, ethanol and cocaine were examined in place conditioning paradigm. After initial preferences were determined, animals were conditioned with morphine (5 mg/kg), ethanol (1 g/kg) and cocaine (5 mg/kg) alone or combinations of these drugs plus some calcium antagonists: nifedipine (5 and 10 mg/kg) and verapamil (5 and 10 mg/kg). Nifedipine prevented the ability of morphine and cocaine, but not of ethanol, to produce a place preference. Our results suggest that substances which can influence calcium distribution are involved in the rewarding actions of some drugs-morphine and cocaine. Dihydropyridine, a calcium channel antagonists might be clinically useful for the treatment of morphine and cocaine abuse.
authors.affiliation: Department of Pharmacodynamics, Medical Academy, Lublin, Poland.
authors.forename: G
authors.initials: G
authors.lastname: Biała
authors.forename: R
authors.initials: R
authors.lastname: Langwiński
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology; D003213:Conditioning, Psychological / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009543:Nifedipine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012201:Reward; D019966:Substance-Related Disorders / Q000503:physiopathology*
chemical_list: D002121:Calcium Channel Blockers; D000431:Ethanol; D009020:Morphine; D003042:Cocaine; D009543:Nifedipine; D002118:Calcium