title: Cytotoxic trichilin-type limonoids from Melia azedarach.
abstract: Five new trichilin-type limonoids, named 12-deacetyltrichilin I (1), 1-acetyltrichilin H (2), 3-deacetyltrichilin H (3), 1-acetyl-3-deacetyltrichilin H (4), 1-acetyl-2-deacetyltrichilin H (5), together with four known trichilins, meliatoxin B1 (6), trichilin H (7), trichilin D (8) and 1,12-diacetyltrichilin B (9) were isolated from the extract of the root bark of Melia azedarach. The structures were elucidated by spectroscopic means and their cytotoxic activities against P388 cells in vitro were tested by means of MTT assay.
authors.affiliation: Department of Natural Medicines, Tokyo University of Pharmacy & Life Science, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Takeya
authors.forename: Z S
authors.initials: ZS
authors.lastname: Quio
authors.forename: C
authors.initials: C
authors.lastname: Hirobe
authors.forename: H
authors.initials: H
authors.lastname: Itokawa
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D007941:Leukemia P388 / Q000188:drug therapy; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014197:Trees / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013256:Steroids