title: Inhibition of hepatitis B surface antigen secretion on human hepatoma cells. Components from Rubia cordifolia.
abstract: The antiviral activity in the roots of Rubia cordifolia was examined, and three naphthohydroquinones, furomollugin (1), mollugin (2), and rubilactone (3), were isolated from it. Compounds 1 and 2 strongly suppressed the secretion of hepatitis B surface antigen (HBsAg), both with IC50 = 2.0 micrograms/mL, in human hepatoma Hep3B cells while having little effect on the viability of the cells. Evaluation of structurally related derivatives of 1 and 2 revealed that a 6-hydroxy group and a pyran or furan ring contribute to this suppressive effect.
authors.affiliation: Department of Pharmacology, National Yang-Ming University, Taipei, Taiwan, Republic of China.
authors.forename: L K
authors.initials: LK
authors.lastname: Ho
authors.forename: M J
authors.initials: MJ
authors.lastname: Don
authors.forename: H C
authors.initials: HC
authors.lastname: Chen
authors.forename: S F
authors.initials: SF
authors.lastname: Yeh
authors.forename: J M
authors.initials: JM
authors.lastname: Chen
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D006801:Humans; D008114:Liver Neoplasms, Experimental / Q000378:metabolism*; D009284:Naphthols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011714:Pyrans / Q000302:isolation & purification* / Q000494:pharmacology; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D006514:Hepatitis B Surface Antigens; D009284:Naphthols; D011714:Pyrans; D011753:Pyrones; C102708:furomollugin; C077500:rubilactone; C046245:rubimaillin