title: Chorion villosum does not express progesterone and estrogen receptors during the first trimester of pregnancy.
abstract: First-trimester chorion villosum plays the key role in the development of human placenta and secretes a large number of hormones and hormone-related substances. To test whether progesterone and estrogen could have regulatory effects on first-trimester chorion villosum functions, we investigated the presence of progesterone receptor (PR) and estrogen receptor (ER) in 47 chorion villosum samples from patients who underwent abortion during the first trimester of pregnancy. The study was carried out using immunohistochemical methods. No ER and PR positivity was evidenced in the 47 chorion villosum samples examined. The possibility that progesterone and estrogen play a role in the regulation of chorion villosum functions should therefore be excluded.
authors.affiliation: Department of Pathology, University of Florence, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Taddei
authors.forename: I
authors.initials: I
authors.lastname: Noei
authors.forename: E
authors.initials: E
authors.lastname: Periti
authors.forename: P
authors.initials: P
authors.lastname: Borri
authors.forename: F
authors.initials: F
authors.lastname: Torricelli
authors.forename: P
authors.initials: P
authors.lastname: Tozzi
authors.forename: D
authors.initials: D
authors.lastname: Moncini
authors.forename: M
authors.initials: M
authors.lastname: Paglierani
authors.forename: F
authors.initials: F
authors.lastname: Branconi
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D002824:Chorionic Villi / Q000276:immunology / Q000378:metabolism*; D015193:Chorionic Villi Sampling; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011960:Receptors, Estrogen / Q000032:analysis* / Q000276:immunology; D011980:Receptors, Progesterone / Q000032:analysis* / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone