title: The RNA polymerase II general elongation factors.
abstract: Synthesis of eukaryotic messenger RNA by RNA polymerase II is governed by the concerted action of a set of general transcription factors that control the activity of polymerase during both the initiation and elongation stages of transcription. To date, five general elongation factors [P-TEFb, SII, TFIIF, Elongin (SIII) and ELL] have been defined biochemically. Here, we discuss these transcription factors and their roles in controlling the activity of the RNA polymerase II elongation complex.
authors.affiliation: Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: D
authors.initials: D
authors.lastname: Reines
authors.forename: J W
authors.initials: JW
authors.lastname: Conaway
authors.forename: R C
authors.initials: RC
authors.lastname: Conaway
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D000075065:Elongin; D009363:Neoplasm Proteins; D010445:Peptide Elongation Factors; D014176:Protein Biosynthesis; D012319:RNA Polymerase II / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism*; D035165:Transcription Factors, General; D019473:Transcription Factors, TFII; D014158:Transcription, Genetic; D035602:Transcriptional Elongation Factors
chemical_list: D004268:DNA-Binding Proteins; C090862:ELL protein, human; D000075065:Elongin; D009363:Neoplasm Proteins; D010445:Peptide Elongation Factors; D014157:Transcription Factors; D035165:Transcription Factors, General; D019473:Transcription Factors, TFII; D035602:Transcriptional Elongation Factors; C018648:transcription factor S-II; D012319:RNA Polymerase II; C056604:transcription factor TFIIF