title: 2-buten 4 olide affects feeding behavior of rhesus monkey.
abstract: 1. Endogenous satiety substance 2-Buten 4 Olide (2-B40- a short chain sugar derivative) effect on feeding behaviour of rhesus monkey was studied. 2. The cannula was implanted in the third ventricle of three, adult, male, rhesus monkeys. 3. Monkeys were conditioned to ingest their daily requirement of food during one hour. 4. Their daily food intake was recorded. 5. Various doses of 2-B40 (1.6, 2.1, 2.7, 4.3, 10.6, 20 and 25 mg)were administered intracerebroventricularly on different days five minutes prior to presentation of food. 6. The effective dose for inducing significant satiety effect was 20.0 mg, while 10.6 mg induced a mild and 25.0 mg a severe effect. 7.However, when administered intraperitoneally 43 mg/kg bw 2-B40 induced satiety effect, but was ineffective in doses of 1.5 to 21.5 mg bw. 8. This study is suggestive of the presence of 2-B40 satiety mechanism in monkeys almost in doses similar to those previously reported for rats.
authors.affiliation: Department of Physiology, All India Institute of Medical Sciences, New Delhi.
authors.forename: R
authors.initials: R
authors.lastname: Mathur
authors.forename: S K
authors.initials: SK
authors.lastname: Manchanda
authors.forename: Y
authors.initials: Y
authors.lastname: Oomura
authors.forename: U
authors.initials: U
authors.lastname: Nayar
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D005663:Furans / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008253:Macaca mulatta; D008297:Male
chemical_list: D005663:Furans; D007166:Immunosuppressive Agents; C004511:butenolide; D015107:4-Butyrolactone