title: Comparison of liquid chromatography, capillary electrophoresis and super-critical fluid chromatography in the determination of Losartan Potassium drug substance in Cozaar tablets.
abstract: Reversed phase liquid chromatography, micellar electrokinetic chromatography, and packed column supercritical fluid chromatography were used to measure the amount of Losartan Potassium drug substance in pharmaceutical tablets. Tablet extract samples were analyzed and results were used to compare accuracy, precision, and linearity of calibration of the instrumental techniques. All three techniques have satisfactory precision (less than 1% RSD) and accuracy to be used for the analysis of the drug substance in tablets and the advantages of each technique are discussed.
authors.affiliation: DuPont Merck Pharmaceutical Co., Wilmington, DE 19880-0353, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Williams
authors.forename: M S
authors.initials: MS
authors.lastname: Alasandro
authors.forename: V L
authors.initials: VL
authors.lastname: Fasone
authors.forename: R J
authors.initials: RJ
authors.lastname: Boucher
authors.forename: J F
authors.initials: JF
authors.lastname: Edwards
mesh_terms: D000959:Antihypertensive Agents / Q000032:analysis*; D001713:Biphenyl Compounds / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D019075:Electrophoresis, Capillary; D007093:Imidazoles / Q000032:analysis*; D019808:Losartan; D012680:Sensitivity and Specificity; D013607:Tablets / Q000032:analysis; D013777:Tetrazoles / Q000032:analysis*
chemical_list: D000959:Antihypertensive Agents; D001713:Biphenyl Compounds; D007093:Imidazoles; D013607:Tablets; D013777:Tetrazoles; D019808:Losartan