title: Glandular tumors of the lacrimal sac. Their histopathologic patterns and possible origins.
abstract: OBJECTIVE
  To describe and characterize the primary lacrimal sac epithelial tumors of glandular origin, and to describe their possible source from glands in the lacrimal sac and nasolacrimal duct walls.
  
  
  METHODS
  The authors conducted a clinicopathologic study on 14 patients with epithelial lacrimal sac tumors of possible glandular origin. In addition, they reviewed 35 surgical specimens of the lacrimal sac and nasolacrimal duct region and 13 cadaver specimens of the lacrimal sac region.
  
  
  RESULTS
  Six of the tumors were benign: four were oncocytomas and two were pleomorphic adenomas. Eight of the tumors were malignant: three were oncocytic adenocarcinomas, three were adenoid cystic carcinomas, and two were adenocarcinomas. All tumors were from adults, ranging in age from 38 to 87 years. Twenty-eight of the 47 specimens of lacrimal sac and nasolacrimal duct region showed mixed glands of serous and mucous elements.
  
  
  CONCLUSIONS
  Although rare, benign and malignant glandular lacrimal sac tumors should be considered in the differential diagnosis of lacrimal sac obstruction. Their possible origin is from the normal glands that exist under the lacrimal sac and nasolacrimal duct epithelium.
authors.affiliation: Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Pe'er
authors.forename: A A
authors.initials: AA
authors.lastname: Hidayat
authors.forename: M
authors.initials: M
authors.lastname: Ilsar
authors.forename: L
authors.initials: L
authors.lastname: Landau
authors.forename: M A
authors.initials: MA
authors.lastname: Stefanyszyn
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D018249:Adenoma, Oxyphilic / Q000473:pathology*; D008949:Adenoma, Pleomorphic / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology*; D005260:Female; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009301:Nasolacrimal Duct / Q000473:pathology*