title: Progressive multifocal leukoencephalopathy: clinical and MR response to treatment.
abstract: Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease that occurs in immunocompromised hosts. We describe two patients with biopsy-proved PML who showed improvement clinically and radiologically after medical therapy. These cases reveal that interval improvement can in rare instances be consistent with a diagnosis of PML.
authors.affiliation: Department of Radiology, Toronto Hospital, Ontario, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Garrels
authors.forename: W
authors.initials: W
authors.lastname: Kucharczyk
authors.forename: G
authors.initials: G
authors.lastname: Wortzman
authors.forename: M
authors.initials: M
authors.lastname: Shandling
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D003561:Cytarabine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D016898:Interferon-alpha / Q000627:therapeutic use*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged
chemical_list: D016898:Interferon-alpha; D003561:Cytarabine