The molecular genetics of schizophrenia.
There is overwhelming evidence for a significant genetic contribution to the etiology of schizophrenia. Molecular genetic techniques are now sufficiently advanced to be applied to complex genetic disorders with uncertain phenotypes, such as schizophrenia. In this article we first briefly discuss certain pertinent background issues: the evidence that schizophrenia has a heritable basis, the possible modes of inheritance involved, and how best to define schizophrenia in the light of this evidence; we then review the current status of research in the field. Large collaborative studies are currently underway that pave the way for the detection of genes of both major and minor effects. We may now be seeing the first consistently replicated results from chromosome 6 and 22 and from candidate genes, such as the dopamine D3 receptor gene.
Murphy
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KC
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK.
Cardno
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McGuffin
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D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D004198:Disease Susceptibility; D004200:Diseases in Twins; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D015995:Prevalence; D044402:Receptor, Serotonin, 5-HT2A; D017448:Receptors, Dopamine D2 / Q000235:genetics; D050637:Receptors, Dopamine D3; D011985:Receptors, Serotonin / Q000235:genetics; D012559:Schizophrenia / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D012569:Schizotypal Personality Disorder / Q000453:epidemiology / Q000235:genetics; D014430:Twins, Monozygotic
C493593:DRD3 protein, human; D044402:Receptor, Serotonin, 5-HT2A; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D011985:Receptors, Serotonin