Platelet/endothelial cell adhesion molecule-1 (PECAM-1) expression by human brain microvessel endothelial cells in primary culture.
PECAM-1 expression was investigated in primary cultures of human brain microvessel endothelial cells (HBMEC). HBMEC constitutively express PECAM-1 along their apical cell surface, advancing processes and on the basal surface at points of contact with the extracellular matrix. Surface expression is not altered by cytokine or lipopolysaccharide treatment. This distribution may mediate cell-cell contract and migration during angiogenesis and HBMEC-leukocyte interactions in CNS inflammation.
Wong
D
D
Department of pathology and Laboratory Medicine, Vancouver Hospital, Canada.
Dorovini-Zis
K
K
D000954:Antigens, Surface / Q000032:analysis / Q000096:biosynthesis; D001921:Brain / Q000098:blood supply*; D002478:Cells, Cultured / Q000737:chemistry / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008833:Microcirculation / Q000737:chemistry; D016253:Microscopy, Immunoelectron; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis* / Q000096:biosynthesis
D000954:Antigens, Surface; D019408:Platelet Endothelial Cell Adhesion Molecule-1