title: The frequency of cutaneous vasculitis is not increased in patients with rheumatoid arthritis treated with methotrexate.
abstract: OBJECTIVE
  To analyse the frequency, type, and immunohistological features of clinical cutaneous vasculitis developing in patients with rheumatoid arthritis (RA) treated or not with methotrexate as well as their demographic, clinical and biological characteristics.
  
  
  METHODS
  Ninety-one patients with RA receiving 9.5 mg/wk of methotrexate (MTX) were compared for an average observation time of 18 months to 130 matched patients with RA treated with various drugs excluding MTX.
  
  
  RESULTS
  Whether receiving MTX or not, 5.4% of patients with RA developed a clinical cutaneous vasculitis. There were significant differences between both groups for 2 variables only: a higher percentage of polyneuropathies and a higher level of immune complex-plasma levels in non-MTX patients. The immunohistological analysis did not differentiate both groups.
  
  
  CONCLUSIONS
  The percentage of cutaneous vasculitis that developed under MTX therapy was not different from that occurring as a natural complication of longstanding severe RA.
authors.affiliation: Service of Rheumatology, University of Liège, CHU du Sart-Tilman, Belgium.
authors.forename: O
authors.initials: O
authors.lastname: Kaye
authors.forename: C C
authors.initials: CC
authors.lastname: Beckers
authors.forename: P
authors.initials: P
authors.lastname: Paquet
authors.forename: J E
authors.initials: JE
authors.lastname: Arrese
authors.forename: G E
authors.initials: GE
authors.lastname: Piérard
authors.forename: M G
authors.initials: MG
authors.lastname: Malaise
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000150:complications / Q000453:epidemiology; D012867:Skin / Q000098:blood supply*; D014657:Vasculitis / Q000150:complications* / Q000453:epidemiology*
chemical_list: D008727:Methotrexate