[Clinical significant correlation between to the onset of bronchial asthma in children and family history of allergic diseases. Part 1. Comparison of various allergic diseases in the family history and onset of bronchial asthma in children].
Two hundred and forty seven asthmatic and 246 non-asthmatic children were evaluated in order to find out the relationship between onset of asthma, family history of allergic diseases (FH) and environmental factors. The results are as it follows. Child with asthmatic symptoms shows high total serum IgE levels with/without FH. Asthma occurs significantly often with FH than without FH. There is no significant difference in onset of asthma between father and mother. Child has more asthma when either father or mother has asthma than allergic rhinitis. We concluded that family history of allergic diseases especially asthma is asthmogenic and environmental factors work as aggravating but not asthmogenic factors. The specific IgE is influenced by condition of the sensitization than family history of allergic diseases.
Shiigai
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Department of Pediatrics, Saitama Medical School.
D001249:Asthma / Q000209:etiology* / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D004781:Environmental Exposure; D005190:Family; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics*; D007073:Immunoglobulin E / Q000097:blood; D008297:Male
D007073:Immunoglobulin E