Phorbol ester intracerebroventricularly induces a behavioral hypoactivity that is not affected by chronic or acute lithium.
Chronic lithium treatment in rats has been reported to decrease protein kinase C alpha isozyme in hippocampal membranes. We gave phorbol ester, a protein kinase C activator, i.c.v. to rats treated with acute or chronic lithium. Low dose phorbol ester causes a marked hypoactivity and high dose phorbol ester causes a barrel rolling behavior, but no behavioral interactions with lithium treatment were observed.
Patishi
Y
Y
Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel.
Bersudsky
Y
Y
Belmaker
R H
RH
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D007278:Injections, Spinal; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D010703:Phorbol Esters / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D010703:Phorbol Esters; D008094:Lithium