Viral inhibition of apoptosis.
Viral propagation is limited both by the host immune response and by apoptosis of infected cells. Viruses circumvent apoptosis by different mechanisms: direct inhibition of particular proteases involved in cell death, stimulation of anti-death pathways or regulation of the activity of transcription factors monitoring cell survival.
Gillet
G
G
Laboratoire de Biologie Moléculaire et Cellulaire, UMR 49 CNRS, ENS Lyon, France. Germain.Gillet@cri.ens-lyon.fr
Brun
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G
D000818:Animals; D017209:Apoptosis; D003546:Cysteine Endopeptidases; D015853:Cysteine Proteinase Inhibitors; D005786:Gene Expression Regulation; D008954:Models, Biological; D019253:Proto-Oncogene Proteins c-bcl-2; D014158:Transcription, Genetic; D014780:Viruses / Q000254:growth & development* / Q000378:metabolism
D015853:Cysteine Proteinase Inhibitors; D019253:Proto-Oncogene Proteins c-bcl-2; D003546:Cysteine Endopeptidases