Physiological regulation of gaba uptake by rat pyloric antral mucosa.
Endocrine cells of the pyloric antral mucosa are known to take up gamma-amino-n-butyric acid (GABA), but the functional significance of this is uncertain. We now report that specific uptake of [3H]GABA by rat antral, but not corpus, mucosa is enhanced after fasting for 48 h. Decreased extracellular GABA in fasted rats could account for known changes in antral endocrine cell function.
Varro
A
A
Physiological Laboratory, University of Liverpool, UK.
Athanassopolous
P
P
Dockray
G J
GJ
D000818:Animals; D005215:Fasting; D018756:GABA Antagonists / Q000494:pharmacology; D005753:Gastric Mucosa / Q000378:metabolism*; D009994:Osmolar Concentration; D011706:Pyloric Antrum / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D005680:gamma-Aminobutyric Acid / Q000378:metabolism* / Q000494:pharmacology
D018756:GABA Antagonists; D005680:gamma-Aminobutyric Acid