Vasodilator responses to desmopressin and its diluent, chlorobutanol, in the hindquarters vascular bed of the cat.
Desmopressin is a synthetic analog of vasopressin used to promote hemostasis and reduce postoperative blood loss. Recent studies have shown that desmopressin decreases arterial blood pressure in the anesthetized rat and relaxes isolated segments of aorta and pulmonary artery. Responses to a clinical preparation of desmopressin were investigated in the hindquarters vascular bed of the cat under constant flow conditions so that changes in perfusion pressure directly reflect changes in vascular resistance. Responses to desmopressin and its vehicle, and the effect of receptor antagonists, inhibitors of prostaglandin, and nitric oxide synthesis inhibitors, were investigated.
Lian
T S
TS
Department of Anesthesiology, Tulane University School of Medicine, New Orleans, Louisiana 70112.
Bellan
J A
JA
Jahr
J S
JS
Holton
R H
RH
Nossaman
B D
BD
Kadowitz
P J
PJ
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002415:Cats; D002724:Chlorobutanol / Q000494:pharmacology; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006614:Hindlimb / Q000502:physiology; D006863:Hydrogen-Ion Concentration; D008469:Meclofenamic Acid / Q000494:pharmacology; D019335:Nitroarginine / Q000494:pharmacology; D010477:Perfusion; D011433:Propranolol / Q000494:pharmacology; D013618:Tachyphylaxis / Q000502:physiology; D014655:Vascular Resistance / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology
D014665:Vasodilator Agents; D019335:Nitroarginine; D008469:Meclofenamic Acid; D001285:Atropine; D011433:Propranolol; D003894:Deamino Arginine Vasopressin; D002724:Chlorobutanol