Changes in renal renin gene expression in fetal sheep.
1. Renin gene expression was investigated in kidneys from 13 foetal and four adult sheep. 2. The levels of renal renin mRNA in foetuses were greater than those in adult sheep (P < 0.001). 3. There was no significant difference in renin mRNA levels between foetuses aged 91 and 134 days (term 150 days). 4. The levels of renin gene expression were higher (178 +/- 5 units; P < 0.001) in foetuses at 142 days than levels in 91 (144 +/- 4 units) and 134 days old foetuses (146 +/- 6 units). 5. It is concluded that the high level of renin gene expression in the foetal kidney is responsible for the high levels of renin in the foetal circulation.
Zhang
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School of Physiology and Pharmacology, University of New South Wales, Sydney, Australia.
Lumbers
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Simonetta
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D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001345:Autoradiography; D005260:Female; D005333:Fetus / Q000187:drug effects; D015870:Gene Expression; D007672:Kidney Cortex / Q000201:enzymology* / Q000254:growth & development; D011247:Pregnancy; D012333:RNA, Messenger / Q000378:metabolism*; D012083:Renin / Q000235:genetics / Q000378:metabolism*; D012756:Sheep
D012333:RNA, Messenger; D012083:Renin