Inhibition of mitochondrial cytochrome C oxidase by dicarbanonaborates.
Dicarbanonaborates inhibit the mitochondrial cytochrome c oxidase activity. In contrast to mitochondrial ATPase or glycerol phosphate dehydrogenase, inhibition of cytochrome c oxidase was not competitive and the residual, drug-insensitive activity was higher. These results indicate that dicarbanonaborates inhibit various mitochondrial membrane-bound enzymes through different mechanisms.
Drahota
Z
Z
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Vrbacký
M
M
Rauchová
H
H
Kalous
M
M
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000818:Animals; D001881:Borates / Q000494:pharmacology*; D003576:Electron Transport Complex IV / Q000037:antagonists & inhibitors*; D005993:Glycerolphosphate Dehydrogenase / Q000037:antagonists & inhibitors; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000201:enzymology; D051381:Rats
D001881:Borates; D005993:Glycerolphosphate Dehydrogenase; D003576:Electron Transport Complex IV; D000251:Adenosine Triphosphatases