Dissociation of blood-brain barrier permeability and the hypotensive effects of the bradykinin B2 agonist, RMP-7.
Elliott
P J
PJ
Alkermes Inc., Cambridge, MA 02139, USA.
Hayward
N J
NJ
Dean
R L
RL
Bartus
R T
RT
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001812:Blood-Brain Barrier / Q000187:drug effects* / Q000502:physiology; D001920:Bradykinin / Q000008:administration & dosage / Q000819:agonists* / Q000031:analogs & derivatives* / Q000494:pharmacology; D001932:Brain Neoplasms / Q000503:physiopathology; D016190:Carboplatin / Q000493:pharmacokinetics; D003911:Dextrans / Q000493:pharmacokinetics; D007022:Hypotension / Q000139:chemically induced*; D010539:Permeability / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D043782:Receptor, Bradykinin B2; D018002:Receptors, Bradykinin / Q000819:agonists
D003911:Dextrans; D043782:Receptor, Bradykinin B2; D018002:Receptors, Bradykinin; C089876:RMP 7; D016190:Carboplatin; D001920:Bradykinin