title: Sequential development of resistance to fluoroquinolones and erythromycin in an isolate of Campylobacter jejuni.
abstract: A severe episode of Campylobacter jejuni gastroenteritis in a patient with HIV infection was treated with ciprofloxacin and, because of therapeutic failure, subsequently with roxithromycin. After treatment, C. jejuni was again isolated from feces and shown to be resistant to both drugs. We present molecular evidence of the sequential development of both types of resistance in the patient isolate. To our knowledge, this is the first case with documented evidence showing sequential emergence of resistance to fluoroquinolones and erythromycin in a strain of C. jejuni during treatment.
authors.affiliation: National Reference Laboratory for Foodborne Diseases, University of Berne, Berne, Switzerland.
authors.forename: A P
authors.initials: AP
authors.lastname: Burnens
authors.forename: M
authors.initials: M
authors.lastname: Heitz
authors.forename: I
authors.initials: I
authors.lastname: Brodard
authors.forename: J
authors.initials: J
authors.lastname: Nicolet
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002169:Campylobacter Infections / Q000150:complications / Q000382:microbiology; D016123:Campylobacter jejuni / Q000187:drug effects* / Q000235:genetics; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D004917:Erythromycin / Q000494:pharmacology*; D024841:Fluoroquinolones; D006679:HIV Seropositivity / Q000150:complications; D006801:Humans; D008297:Male; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D004917:Erythromycin