A benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy.
In a double-blind, randomized, controlled study, the effectiveness of treatment with a combination of Benfotiamine (an Allithiamine, a lipid-soluble derivative of vitamin B1 with high bioavailability) plus vitamin B6/B12 on objective parameters of neuropathy was studied over a period of 12 weeks on 24 diabetic patients with diabetic polyneuropathy. The results showed a significant improvement (p = 0.006) of nerve conduction velocity in the peroneal nerve and a statistical trend toward improvement of the vibration perception threshold. Long-term observation of 9 patients with verum over a period of 9 months support the results. Therapy-specific adverse effects were not seen. The results of this double-blind investigation, of the long-term observation and of the reports in the literature support the contention that the neurotropic benfotiamine-vitamin B combination represents a starting point in the treatment of diabetic polyneuropathy.
Stracke
H
H
Third Medical Department, University of Giessen, Germany.
Lindemann
A
A
Federlin
K
K
D000284:Administration, Oral; D000368:Aged; D002214:Capsules; D003929:Diabetic Neuropathies / Q000188:drug therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006442:Glycated Hemoglobin / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000502:physiology; D008875:Middle Aged; D009431:Neural Conduction / Q000187:drug effects / Q000502:physiology; D010465:Perception / Q000187:drug effects / Q000502:physiology; D010543:Peroneal Nerve / Q000502:physiology; D011736:Pyridoxine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D012684:Sensory Thresholds / Q000187:drug effects / Q000502:physiology; D013831:Thiamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D013997:Time Factors; D014732:Vibration; D014805:Vitamin B 12 / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D002214:Capsules; D004338:Drug Combinations; D006442:Glycated Hemoglobin; D011736:Pyridoxine; D013831:Thiamine; D014805:Vitamin B 12; C013835:benphothiamine