title: The hypertrophic scar and microcirculation properties.
abstract: Blood-flow measurements of microcirculation were used as a quantitative indicator for scar assessment and healing. A laser doppler flowmeter (LDF), giving an integrated instantaneous flux value through a measured volume of skin, was used for the measurements. It has been postulated that the degree of hypertrophy after thermal injury correlates with the degree of microvascular regeneration. This study looked quantitatively at microcirculation in normal and scarred skin of different clinical grading and investigated the comparative responses to changes in local temperature stimuli. An attempt is made to define microcirculation using the parameters of Vasodilation Index (Dli) and Vasomotion Intensity (% Vsm) as respective responses to a rise in local temperature of the skin from 36 degrees C to 44 degrees C. The improvements in both Dli and % Vsm with healing of scar relate to the degree of microvascular regeneration, which in turn correlates with the clinical assessment.
authors.affiliation: Department of Mechanical Engineering, University of Hong Kong.
authors.forename: J A
authors.initials: JA
authors.lastname: Clark
authors.forename: K S
authors.initials: KS
authors.lastname: Leung
authors.forename: J C
authors.initials: JC
authors.lastname: Cheng
authors.forename: P C
authors.initials: PC
authors.lastname: Leung
mesh_terms: D000293:Adolescent; D000328:Adult; D001783:Blood Flow Velocity; D002056:Burns / Q000150:complications; D017439:Cicatrix, Hypertrophic / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008297:Male; D008833:Microcirculation; D012867:Skin / Q000098:blood supply*