Thymocyte and splenocyte subpopulations in normal and leukemia-bearing mice after adrenalectomy.
Mice with i.p. inoculated leukemia L1210 cells had lower total number of thymocytes, and reduced number of CD4+8+ thymocytes, but increased CD4+8- subpopulation. Adrenalectomy reduced the CD4-8+ subset of thymocytes. Leukemia in adrenalectomized animals induced similar changes in the number of thymocyte subpopulations as observed in normal animals. However, a decrease in CD4+8- thymocytes was noted and the animals had decreased number of CD4-8- cells as well. Splenocytes of CD4+8- subpopulation were more numerous in adrenalectomized animals. Leukemia induced increase in the number of CD4+8- and CD4-8+ splenocytes in both normal and adrenalectomized animals.
Kawiak
J
J
Medical Centre of Postgraduate Education, Department of Clinical Cytology, Warsaw, Poland.
Hoser
G
G
Malendowicz
L K
LK
Miks
B
B
Skurzak
H
H
D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D016516:CD4-CD8 Ratio; D005260:Female; D007939:Leukemia L1210 / Q000276:immunology* / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D013154:Spleen / Q000166:cytology* / Q000276:immunology; D016176:T-Lymphocyte Subsets; D013950:Thymus Gland / Q000166:cytology* / Q000276:immunology