HLA DQ-DR haplotype and susceptibility to cervical carcinoma: indications of increased risk for development of cervical carcinoma in individuals infected with HPV 18.
The association of HLA class II DQB1 and DRB1 alleles with the development of cervical carcinoma was studied in 150 Swedish patients using PCR-based HPV and HLA typing. The association of cervical carcinoma with alleles encoding the DQ3 antigen, previously found among German and Norwegian patients, was not observed in the Swedish patients. Five DQ-DR haplotypes were indicated to be positively associated with development of cervical carcinoma in the Swedish patients. Two of these HLA associations were specific for HPV 18 infected patients, suggesting that the ability of the oncogenic HPV 18 to cause more rapid-transit tumors than other high risk HPV types may be due to a deficiency in antigen presentation by the HLA molecules encoded by carried on these haplotypes.
Allen
M
M
Department of Medical Genetics, Biomedical Center, University of Uppsala, Sweden.
Kalantari
M
M
Ylitalo
N
N
Pettersson
B
B
Hagmar
B
B
Scheibenpflug
L
L
Johansson
B
B
Petterson
U
U
Gyllensten
U
U
D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000235:genetics*; D005260:Female; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics; D030361:Papillomavirus Infections / Q000150:complications* / Q000235:genetics; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D014412:Tumor Virus Infections / Q000150:complications / Q000235:genetics; D002583:Uterine Cervical Neoplasms / Q000209:etiology / Q000235:genetics*
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens