title: [Epidural lipomatosis: complication of long-term corticotherapy. Apropos of 2 cases].
abstract: Spinal epidural lipomatosis (SEL) is defined as the deposition of loose fat tissue in the epidural space. Two cases are reported which illustrate the main features of this uncommon disease. Most frequently SEL is revealed by neurologic manifestations such as an acute chronic spinal cord compression. Corticosteroid therapy and obesity are the main factors able to induce the disease. The common location of the SEL at the thoracic spine is explained by the physiologic abundance of fat and by the relative narrowness of the spinal canal at this level. An osteoporotic vertebral crush fracture which reduces the diameter of the canal frequently reveals the SEL. MRI confirms the diagnosis of SEL and shows the extent in the spinal canal. The treatment of SEL is difficult. The decrease or the stop of corticosteroid therapy has allowed the recovery in a few cases with chronic neurologic symptoms. The risks of a surgical procedure are important in these patients and the medical or surgical treatment should be discussed taking into account the clinical symptoms of SEL, its location and extent, and the risks of recurrence if corticosteroid therapy must go on.
authors.affiliation: Service de rhumatologie, hôpital Lapeyronie, CHU, Montpellier, France.
authors.forename: L
authors.initials: L
authors.lastname: Dujardin
authors.forename: C
authors.initials: C
authors.lastname: Marcelli
authors.forename: C
authors.initials: C
authors.lastname: Hérisson
authors.forename: L
authors.initials: L
authors.lastname: Simon
mesh_terms: D000328:Adult; D001416:Back Pain / Q000209:etiology / Q000628:therapy; D004824:Epidural Space; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D008068:Lipomatosis / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000009:adverse effects*; D013117:Spinal Cord Compression / Q000209:etiology / Q000628:therapy; D016103:Spinal Fractures / Q000209:etiology / Q000628:therapy; D013997:Time Factors
chemical_list: D005938:Glucocorticoids; D011241:Prednisone