Pupillary response to topical tropicamide as a marker for Alzheimer's disease.
The mydriatic response to eyedrops of the anticholinergic drug tropicamide at very low concentration (0.01%) was studied in subjects with Alzheimer's disease (AD, n = 10) and multi-infarct dementia (MID, n = 10). There was no significant difference in pupillary response between the two groups. The test is unlikely to be useful in differentiating different types of dementia.
Treloar
A J
AJ
Division of Psychiatry, United Medical and Dental Schools (Guy's), Bexley Hospital, Kent, UK.
Assin
M
M
Macdonald
A J
AJ
D000287:Administration, Topical; D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology*; D006801:Humans; D011680:Pupil / Q000187:drug effects*; D014331:Tropicamide / Q000008:administration & dosage*
D014331:Tropicamide