title: Bone lymphoma. Comparison of Tl-201 and Ga-67 citrate scintigraphy in assessment of treatment response.
abstract: Assessment of response to therapy in patients with lymphoma involving bone can be difficult. Of the scintigraphic techniques available, Tl-201 may be the most ideal radiopharmaceutical because it reflects tumor burden more accurately than either Tc-99m MDP or Ga-67 citrate. We compared serial Tl-201 and Ga-67 citrate scintigraphs (24 studies, 12 pairs) in assessing the response to therapy in three patients with non-Hodgkin's lymphoma involving bone. In two patients who demonstrated a complete remission, uptake of Tl-201 diminished more rapidly and returned to normal earlier than did Ga-67 citrate. Tl-201 did not show tumor recurrence in the one patient with lesions shown to be Tl-201 negative at baseline. Serial studies using Tl-201 may be superior to Ga-67 citrate in the evaluation of lymphoma involving bone provided that Tl-201 avidity is demonstrated on baseline studies.
authors.affiliation: Department of Radiology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Roach
authors.forename: M J
authors.initials: MJ
authors.lastname: Janicek
authors.forename: W D
authors.initials: WD
authors.lastname: Kaplan
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002951:Citrates; D005260:Female; D005708:Gallium; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D013794:Thallium Radioisotopes
chemical_list: D002951:Citrates; D013794:Thallium Radioisotopes; D005708:Gallium; C103850:gallium citrate