title: Butachlor impact on protein, free amino acid and glutamine contents, and on activity levels of aminotransferases, glutamate dehydrogenase and glutamine synthetase in the fresh water snail, Pila globosa (Swainson).
abstract: Biochemical changes followed in the freshwater snail Pila globosa (Swainson) during exposure to sublethal concentrations of the herbicide butachlor (26.6 ppm) in the ambient medium, at 3,6,12,24 and 48 h intervals, were marked by a significant decrease in total and soluble proteins, and an increase in free amino acids in foot and hepatopancreas up to 12 h before gradually recovering. Aminotransferase activities and glutamine content decreased during the early periods of exposure, while glutamate dehydrogenase activity increased. After an initial elevation, glutamate synthetase activity decreased at later intervals. Maximum effect of butachlor on the enzymes was seen after 12 h exposure. The extent of increase or decrease in different parameters examined varied between the two tissues studied. These changes are discussed in relation to the toxic stress of butachlor.
authors.affiliation: Department of Zoology, Sri Venkateswara University, Tirupati, India.
authors.forename: T
authors.initials: T
authors.lastname: Rajyalakshmi
authors.forename: T
authors.initials: T
authors.lastname: Srinivas
authors.forename: K V
authors.initials: KV
authors.lastname: Swamy
authors.forename: P M
authors.initials: PM
authors.lastname: Mohan
mesh_terms: D000083:Acetanilides / Q000494:pharmacology* / Q000633:toxicity; D000596:Amino Acids / Q000737:chemistry* / Q000187:drug effects; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005618:Fresh Water; D005969:Glutamate Dehydrogenase / Q000187:drug effects / Q000378:metabolism; D005974:Glutamate-Ammonia Ligase / Q000187:drug effects / Q000378:metabolism; D005973:Glutamine / Q000737:chemistry / Q000187:drug effects; D018482:Muscle, Skeletal / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D010179:Pancreas / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D011506:Proteins / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D012908:Snails / Q000187:drug effects* / Q000378:metabolism*; D000637:Transaminases / Q000187:drug effects / Q000378:metabolism
chemical_list: D000083:Acetanilides; D000596:Amino Acids; D011506:Proteins; D005973:Glutamine; C054409:butachlor; D005969:Glutamate Dehydrogenase; D000637:Transaminases; D005974:Glutamate-Ammonia Ligase