title: Reproductive parameters of older compared to younger men of infertile couples.
abstract: In order to evaluate possible age-dependent influences on male infertility, semen parameters, sex hormone levels and pregnancy rates were compared retrospectively in three groups of men attending our fertility clinic: group A: 39 patients > 50 years. Group B (39 patients < 30 years) was established as the 'standard infertile patient' seen in our Institute. These patients were matched with patients of group A according to the year of their first visit to the clinic. Group C: 39 young patients (< 30 years) who were selected on the basis of their wives' advanced age. The frequency of sexual intercourse in group A was significantly lower compared to group C. The period of sexual abstinence was longer in group A than in group B. Ejaculate volume and sperm motility in group A were lower compared to groups B and C. The differences in other semen parameters were only minor. The differences in serum levels of testosterone and FSH were significant between group A and groups B and C. Pregnancies were reported in 6 of 26 couples from group A (duration of infertility: mean 79 months, range 16-187), in 17 of 28 couples from group B (duration of infertility; mean 54 months, range 16-104) and in nine of 30 couples from group C (duration of infertility; mean 66 months, range 25-125). Since the infertility pattern of the older patients desiring offspring was not significantly different from that of younger patients, it is concluded that the age of the female partner, rather than the age of the husband, is most important in determining the fertility chances of couples presenting with infertility.
authors.affiliation: Institute of Reproductive Medicine of the University, Münster, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Rolf
authors.forename: H M
authors.initials: HM
authors.lastname: Behre
authors.forename: E
authors.initials: E
authors.lastname: Nieschlag
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D003075:Coitus; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D007248:Infertility, Male; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011247:Pregnancy; D018873:Pregnancy Rate; D012661:Semen; D013737:Testis / Q000473:pathology
chemical_list: D012739:Gonadal Steroid Hormones