Herpetic viruses and spontaneous recovery in melanoma.
The malignant melanoma may display extremely variable forms of development, from clinical forms with a lethal course to the unforeseeable situations of spontaneous cures. The basic immunotherapeutic procedures, as well as hypotheses regarding the mechanisms involved in courses towards spontaneous regressions, are presented. Since viruses of the herpes genus are involved in the mechanisms assumed to be at the basis of spontaneous regressions, it is suggested that these viruses (selected strains) be used in the clinic, in order to check the advanced hypothesis, an opportunity which could permit to study also the very probable therapeutic alternative offered by this virus, namely the association of the well-known immunotherapeutic methods.
Motofei
I G
IG
C. Davila University of Medicine and Pharmacy, Bucharest, Romania.
D001327:Autoimmune Diseases; D006566:Herpesviridae Infections / Q000503:physiopathology*; D006801:Humans; D008545:Melanoma; D008954:Models, Biological; D009365:Neoplasm Regression, Spontaneous