title: A comparison of venovenous and venoarterial extracorporeal membrane oxygenation in the treatment of neonatal respiratory failure.
abstract: OBJECTIVE
  To compare the efficacy of venovenous to venoarterial bypass in an unselected cohort of infants with refractory cardiorespiratory failure.
  
  
  METHODS
  Retrospective cohort analysis.
  
  
  METHODS
  Two tertiary hospitals capable of providing extracorporeal life support for neonates with acute respiratory failure.
  
  
  METHODS
  All San Diego Regional Extracorporeal Membrane Oxygenation (ECMO) Program patients treated after the adoption of a policy which eliminated traditional restrictions to venovenous support.
  
  
  METHODS
  Venoarterial or venovenous extracorporeal life support.
  
  
  RESULTS
  Fifty-four infants were treated with venovenous bypass; 30 were treated with venoarterial bypass due to unsuccessful placement of the double lumen venovenous catheter or inability to exclude congenital heart disease before cannulation. No patient required conversion from venovenous to venoarterial ECMO. There were no differences in birth weight, gestational age, diagnosis, or pre-ECMO condition in the two groups. Patients who met ECMO criteria early were more likely to be successfully cannulated with a double-lumen venovenous catheter. Severe hemodynamic compromise was present before cannulation in a comparable percentage of venovenous and venoarterial patients. During venovenous bypass, mean Pao2 values were lower but remained in the normoxic range; Paco2 values, ventilatory setting, intravascular volume requirements, inotropic support, and mean duration of ECMO support were not different. The frequency rate of patient and mechanical complications were also comparable, except that the frequency of intravascular thrombosis was significantly lower in patients receiving venovenous ECMO. Survival, the frequency rate of chronic lung disease, and neurodevelopmental outcome were similar in the two groups.
  
  
  CONCLUSIONS
  We conclude that venovenous ECMO using a double-lumen venovenous catheter can provide results comparable with venoarterial bypass without the need for carotid artery ligation in an unselected population of neonatal ECMO candidates. In our experience, reported contraindications to venovenous ECMO did not prove to be valid.
authors.affiliation: Department of Pediatrics, Children's Hospital and Health Center, San Diego, CA 92123, USA.
authors.forename: G R
authors.initials: GR
authors.lastname: Knight
authors.forename: G G
authors.initials: GG
authors.lastname: Dudell
authors.forename: M L
authors.initials: ML
authors.lastname: Evans
authors.forename: P S
authors.initials: PS
authors.lastname: Grimm
mesh_terms: D015331:Cohort Studies; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D017063:Outcome Assessment, Health Care; D012131:Respiratory Insufficiency / Q000628:therapy*; D012189:Retrospective Studies