title: Prenatal exposure to cocaine disrupts discrimination learning in adult rabbits.
abstract: Previous studies had shown that intrauterine exposure to cocaine produces an increase in the number of immunoreactive GABA neurons and abnormal dendritic structure of pyramidal cells in the anterior cingulate cortex, a brain region known to be involved in attentional processes and discrimination learning. Because structural abnormalities might be expected to produce related functional deficits, we examined whether intrauterine exposure to cocaine would affect discrimination learning in adult rabbits. We previously reported that cocaine progeny undergoing concurrent acquisition to visual and auditory CSs show a normal rate of learning to a light CS and an accelerated rate of learning to a tone. Here, we report that adult, Dutch-belted rabbits exposed to cocaine in utero showed impaired discrimination learning when responding to a positive visual cue but not when responding to a positive auditory cue. The nature of the deficit consisted of an impaired ability to acquire learned responses to the visual CS+ rather than in an impaired ability to withhold responses to the auditory CS-. Given that auditory stimuli tend to be more salient than visual stimuli in the normal rabbit, the preceding pattern of results suggests that intrauterine cocaine exposure affected the ability to preferentially attend to less salient but relevant stimuli and to ignore more salient, irrelevant stimuli. More importantly, these results indicate that prenatal exposure to cocaine produces neurobehavioral abnormalities which persist into adult life.
authors.affiliation: Department of Pharmacology, Medical College of Pennsylvania, Philadelphia 19129, USA. romano@ccc.medcolpa.edu
authors.forename: A G
authors.initials: AG
authors.lastname: Romano
authors.forename: J A
authors.initials: JA
authors.lastname: Harvey
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003042:Cocaine / Q000494:pharmacology*; D003463:Cues; D004192:Discrimination, Psychological / Q000187:drug effects*; D005260:Female; D007858:Learning / Q000187:drug effects*; D018811:Maternal Exposure; D011817:Rabbits
chemical_list: D003042:Cocaine