Properties controlling the diffusion and release of water-soluble solutes from poly(ethylene oxide) hydrogels: 3. Device geometry.
The diffusive release from hydrogels can be determined by both composition and geometry. This paper presents a theoretical and experimental comparison of the release characteristics of proxyphylline in water-swollen slabs, spheres, and cylinders of a urethane cross-linked poly(ethylene oxide). Contrary to general conventional wisdom it was found that practically cylinders and spheres, which have considerable potential advantages for oral delivery, can provide good 'anomalous' rates for which the 'exponent of release' into water from the dry xerogels is c. 0.8 compared with 1.0 for zero order. An exponent of 0.94 was found for release into water from 'larger' xerogel flat slabs thus confirming that these configurations can provide essentially constant delivery formulations from which the active agent cannot be 'dumped'. For up to 40% total drug release, the theoretical release profiles were essentially of identical form for all three geometries in the swollen state and, as expected in theory and practice, showed an exponent for release of close to 0.5. However, the experimental release of proxyphylline was found to be more sustained from swollen spheres of these polymers than theory would predict. The half life times for release were further extended by approximately two and a half times for the initially dry devices compared with the initially swollen ones.
McNeill
M E
ME
Department of Pure & Applied Chemistry, University of Strathclyde, Glasgow, UK.
Graham
N B
NB
D000628:Aminophylline / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy*; D003432:Cross-Linking Reagents; D004058:Diffusion; D016503:Drug Delivery Systems; D005782:Gels; D006207:Half-Life; D008433:Mathematics; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry / Q000378:metabolism*; D012995:Solubility; D013499:Surface Properties; D013806:Theophylline / Q000031:analogs & derivatives; D014520:Urethane / Q000737:chemistry; D014867:Water
D003432:Cross-Linking Reagents; D005782:Gels; D014867:Water; C003237:proxyphylline; D000628:Aminophylline; D014520:Urethane; D011092:Polyethylene Glycols; D013806:Theophylline