Apparent self-limited androgen excess in a 4 year-old male.
We describe a 4 year-old male with significant virilization, but no source of endogenous or exogenous androgen excess after extensive testing. Evaluation of androgen receptor function, 5 alpha-reductase activity, steroid hormone secretion patterns, and androgen metabolite concentrations were also within the normal range. Over a 10 month period there was spontaneous resolution of the physical and behavioral signs of androgenization. We postulate a self-limited process of androgen production which may represent a yet undefined pattern of sexual precocity in males.
Clark
P A
PA
Department of Pediatrics, University of Virginia, Charlottesville 22908, USA.
Rogol
A D
AD
D001827:Body Height; D001835:Body Weight; D002675:Child, Preschool; D006801:Humans; D017588:Hyperandrogenism / Q000175:diagnosis*; D008297:Male; D011629:Puberty, Precocious