title: A new saxitoxin analogue from a xanthid crab Atergatis floridus.
abstract: A novel paralytic toxin was isolated from toxic specimens of a xanthid crab Atergatis floridus inhabiting the Pacific coast of Shikoku Island. Its structure was deduced to be 11-saxitoxinethanoic acid (SEA) based on high-performance liquid chromatography, electrospray ionization mass spectrometry, and 1H and 13C-NMR spectrometries. This acid was assumed to exist as an equilibrium mixture of three tautomers, the main tautomer being the hydrate form 11 beta-epimer. SEA showed a specific toxicity of 830 mouse units per mumole on i.p. injection into mice.
authors.affiliation: Faculty of Fisheries, Kagoshima University, Japan.
authors.forename: O
authors.initials: O
authors.lastname: Arakawa
authors.forename: S
authors.initials: S
authors.lastname: Nishio
authors.forename: T
authors.initials: T
authors.lastname: Noguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Shida
authors.forename: Y
authors.initials: Y
authors.lastname: Onque
mesh_terms: D019342:Acetic Acid / Q000378:metabolism; D000818:Animals; D003386:Brachyura; D002851:Chromatography, High Pressure Liquid; D005397:Fish Venoms / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D012015:Reference Standards; D012530:Saxitoxin / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism
chemical_list: D005397:Fish Venoms; D012530:Saxitoxin; D019342:Acetic Acid