Effects of aluminum chloride on normal and uremic adult male rats. Tissue distribution, brain choline acetyltransferase activity, and some biological variables.
Normal and uremic adult male rats were given a daily ip injection of 20 mg Al (Al chloride)/kg for 14 d. The results indicate that Al induces a significant decrease in food ingestion, weight gain, and total protein concentration in the plasma. Compared with control animals, very high increases in Al levels were found in plasma and hepatic homogenates (about 36 and 19 times, respectively). In the brain homogenates, the Al increases were lower (about 23%). The brain cholineacetyltransferase activity was reduced: 10.6 and 14.9% in normal and uremic rats, respectively. The nephrectomy and the food restriction did not affect the total protein concentrations in plasma and the cerebral cholineacetyltransferase activity. Both were only found to be reduced in the rats treated by Al chloride.
Cherroret
G
G
Centre des Sciences de l'Environnement, Toxicologie, Université de Metz, France.
Desor
D
D
Hutin
M F
MF
Burnel
D
D
Capolaghi
B
B
Lehr
P R
PR
D000535:Aluminum / Q000097:blood / Q000378:metabolism; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000008:administration & dosage / Q000633:toxicity*; D000704:Analysis of Variance; D000818:Animals; D001252:Astringents / Q000008:administration & dosage / Q000633:toxicity*; D001798:Blood Proteins / Q000187:drug effects / Q000378:metabolism; D002712:Chlorides / Q000008:administration & dosage / Q000633:toxicity*; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology; D004435:Eating / Q000187:drug effects; D005508:Food Deprivation; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009392:Nephrectomy; D016548:Prosencephalon / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar; D014511:Uremia / Q000378:metabolism / Q000503:physiopathology*; D015430:Weight Gain / Q000187:drug effects
D017607:Aluminum Compounds; D001252:Astringents; D001798:Blood Proteins; D002712:Chlorides; D000077410:Aluminum Chloride; D000535:Aluminum; D002795:Choline O-Acetyltransferase