title: Hepatic phosphorus-31 magnetic resonance spectroscopy in primary biliary cirrhosis and its relation to prognostic models.
abstract: BACKGROUND
  In vivo hepatic phosphorus-31 magnetic resonance spectroscopy (31P MRS) provides biochemical information about phosphorus metabolism.
  
  
  OBJECTIVE
  To assess 31P MRS as a prognostic marker in patients with primary biliary cirrhosis (PBC) in relation to the current clinical prognostic models.
  
  
  METHODS
  Twenty three patients with PBC of varying functional severity and 16 matched healthy volunteers were studied using in vivo 31P MRS. Spectra were acquired using a 1.5 T spectroscopy system. Peak area ratios of phosphomonoesters (PME), inorganic phosphate (Pi), and phosphodiesters (PDE) and nucleotide triphosphate (NTP) were calculated. Pugh score, Christensen prognostic index, and R value according to the Mayo model were calculated from the clinical data.
  
  
  RESULTS
  The PME/NTP, Pi/NTP, PME/PDE, and PME/Pi ratios and the PME signal height ratio (SHR) were significantly higher, while the PDE/NTP and PDE/SHR were significantly lower in PBC patients compared with healthy volunteers (p < 0.01). Significant correlations were seen between PME/Pi ratio and the prognostic index according to Christensen (r = 0.63, p < 0.001), R value according to the Mayo model (r = 0.45, p < 0.03), and with the Pugh score (r = 0.55, p < 0.007).
  
  
  CONCLUSIONS
  This study shows that PME/Pi ratio obtained from 31P MRS correlates well with all three of the commonly used models of prognosis in patients with PBC. A longitudinal study with larger number of patients is required to confirm these findings and elucidate the biochemical changes underlying this phenomenon.
authors.affiliation: Robert Steiner Magnetic Resonance Unit, Hammersmith Hospital, London.
authors.forename: R
authors.initials: R
authors.lastname: Jalan
authors.forename: J
authors.initials: J
authors.lastname: Sargentoni
authors.forename: G A
authors.initials: GA
authors.lastname: Coutts
authors.forename: J D
authors.initials: JD
authors.lastname: Bell
authors.forename: K
authors.initials: K
authors.lastname: Rolles
authors.forename: A K
authors.initials: AK
authors.lastname: Burroughs
authors.forename: S D
authors.initials: SD
authors.lastname: Taylor Robinson
mesh_terms: D000328:Adult; D015415:Biomarkers; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D010761:Phosphorus Radioisotopes; D010865:Pilot Projects; D011379:Prognosis
chemical_list: D015415:Biomarkers; D010761:Phosphorus Radioisotopes