title: Solitary eccrine syringofibroadenoma (or eccrine syringofibroadenomatous hyperplasia?) and diabetic polyneuropathy.
abstract: A 70-year-old diabetic woman with sensory polyneuropathy presented with osteonecrosis of the toes and a plaque-like lesion on the dorsum of the ipsilateral foot. Histological diagnosis of eccrine syringofibroadenoma (ES) was made. A review of the literature reveals several cases of solitary ES of the foot in diabetic patients with peripheral neuropathy. This variant of ES seems to be an eccrine sweat duct hyperplasia during the restoration of skin structures damaged by traumas in a situation of peripheral neuropathy. Diabetes and polyneuropathy should be searched for in patients with ES, particularly in acral locations.
authors.affiliation: Division of Pathology, G. Gaslini Institute, University of Genoa, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Gambini
authors.forename: F
authors.initials: F
authors.lastname: Rongioletti
authors.forename: M T
authors.initials: MT
authors.lastname: Semino
authors.forename: A
authors.initials: A
authors.lastname: Rebora
mesh_terms: D006607:Adenoma, Sweat Gland / Q000150:complications / Q000473:pathology*; D000368:Aged; D048909:Diabetes Complications; D003929:Diabetic Neuropathies / Q000150:complications* / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D018226:Fibroadenoma / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D005533:Foot Dermatoses / Q000150:complications / Q000473:pathology; D006801:Humans; D012878:Skin Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D013544:Sweat Gland Neoplasms / Q000150:complications / Q000473:pathology*