The iothalamate clearance in cats with experimentally induced renal failure.
Plasma iothalamate (IOT) disappearance rates were measured after a single-injection of IOT (113.8 mg/kg, IV) in cats with experimentally induced renal failure. The disappearance rates especially fitted into the one compartment model. The mean value of plasma disappearance rates of IOT in these cats with induced renal failure (2.16 +/- 0.240 x 10(-3) micrograms/ml/min) was markedly lower than that of clinically healthy cats (4.10 +/- 1.00 x 10(-3) micrograms/ml/min). These results demonstrate that IOT clearance is available for evaluation of renal function in cats.
Ohashi
F
F
Department of Veterinary Surgery, Faculty of Agriculture, Osaka Prefecture University, Japan.
Kuroda
K
K
Shimada
T
T
Shimada
Y
Y
Ota
M
M
D000818:Animals; D002415:Cats; D002851:Chromatography, High Pressure Liquid; D005919:Glomerular Filtration Rate; D007275:Injections, Intravenous; D007483:Iothalamic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate; D012016:Reference Values; D051437:Renal Insufficiency / Q000097:blood / Q000503:physiopathology*; D013997:Time Factors
D007483:Iothalamic Acid