title: A method for determination of the anisotropic properties of biomembranes.
abstract: A methodology was developed for potential determination of the anisotropic properties of biomembranes. This method is based on the theoretical discretization of a continuous membrane used for finite element analysis and the simultaneous measurement of the displacement of nodes on the surface of a membrane. From the given loads and measured nodal displacements, one can assemble the resulting stiffness matrix and approximate the material properties associated with the membrane. Mathematical estimations and computer simulations were performed to determine the perturbation of load and displacement errors on the resulting material properties. The results indicated that the material properties are particularly sensitive to displacement errors. The displacement measurements may require an accuracy of 20 microns for a 4 x 4 cm2 specimen. Significant inaccuracies occur close to the points of load application.
authors.affiliation: Department of Orthopedics, Mayo Clinic/Mayo Foundation, Rochester, Minnesota 55905, USA.
authors.forename: Z P
authors.initials: ZP
authors.lastname: Luo
authors.forename: J
authors.initials: J
authors.lastname: Grabowski
authors.forename: K N
authors.initials: KN
authors.lastname: An
mesh_terms: D016880:Anisotropy; D008566:Membranes; D008962:Models, Theoretical