The SCID-hu mouse: an in-vivo model for HIV-1 pathogenesis and stem cell gene therapy for AIDS.
Animal models are critical to the investigation of human immunodeficiency virus type 1 (HIV-1) pathogenesis. However, normal animal models are either uninfectable with HIV-1, or if infected, do not display HIV-1 induced pathology. Here, we describe how the severe combined immunodeficient mouse (SCID), implanted with human fetal thymus and liver, has been used to model HIV-1 pathogenesis and anti-retroviral gene therapy. Unable to reject the human tissue, these chimeric mice provide the investigator with a human hematolymphoid organ which, following infection by HIV-1, may more closely mimic the situation seen in humans than standard in-vitro culture systems.
Jamieson
B D
BD
Department of Medicine, UCLA School of Medicine 90095-1678, USA.
Aldrovandi
G M
GM
Zack
J A
JA
D000163:Acquired Immunodeficiency Syndrome / Q000628:therapy; D000818:Animals; D015316:Genetic Therapy / Q000379:methods; D015658:HIV Infections / Q000209:etiology* / Q000628:therapy*; D015497:HIV-1; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D018183:Transplantation Chimera