Antibodies against Candida: potential therapeutics?
For many years, there has been controversy over the role of antibodies in immunity to Candida, but recently specific antibodies to mannoproteins and hsp90 have been shown to be protective against murine candidiasis. Combined with technical advances in antibody engineering, this raises the possibility of harnessing such antibodies into a new range of therapeutics.
Matthews
R
R
University Dept of Medical Microbiology, Manchester Royal Infirmary, UK.
Burnie
J
J
D000818:Animals; D000908:Antibodies, Fungal / Q000627:therapeutic use*; D000946:Antigens, Fungal / Q000276:immunology*; D002177:Candidiasis / Q000517:prevention & control*; D004195:Disease Models, Animal; D018841:HSP90 Heat-Shock Proteins / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000276:immunology*; D051379:Mice; D051381:Rats; D011987:Receptors, Steroid
D000908:Antibodies, Fungal; D000946:Antigens, Fungal; D018841:HSP90 Heat-Shock Proteins; D008562:Membrane Glycoproteins; D011987:Receptors, Steroid; C025363:mannoproteins