Pathogenesis of AIDS--related Kaposi's sarcoma. Evidence of a viral etiology.
Kaposi's sarcoma is the most common malignancy in patients with HIV infection. New studies point to the involvement of a new human Kaposi's sarcoma herpes virus (KSHV) as a transforming agent. After transformation, cytokine perturbations facilitate growth and in some cases clonal growth occurs. This results in a malignancy with devastating clinical consequences. A clear understanding of the mechanism of transformation by KSHV will lead to better therapies.
Miles
S A
SA
Department of Medicine, University of California, Los Angeles, School of Medicine, USA.
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000473:pathology; D016207:Cytokines / Q000502:physiology; D019288:Herpesvirus 8, Human / Q000235:genetics; D006801:Humans; D012514:Sarcoma, Kaposi / Q000209:etiology / Q000382:microbiology / Q000473:pathology*
D016207:Cytokines