Reduced hepatic functional reserve in cirrhosis and obstructive jaundice with special reference to histological morphometric analysis and galactose elimination capacity.
To evaluate liver dysfunction in patients with obstructive jaundice (OJ), morphological and functional hepatic mass was analyzed in comparison with cirrhosis (LC). Total hepatic parenchymal ratio (THPR) was estimated by morphometric analysis and hepatic functional mass by galactose tolerance test (GaTT) in 30 patients who underwent hepatectomy. The value of GaTT in patients with LC was remarkably depressed compared to those with normal liver function (p < 0.001). It was also depressed in OJ (p < 0.05 vs. normal liver), but less than in LC (p < 0.05). However, THPR decreased only in LC (p < 0.05 vs. either normal liver or OJ). A significant correlation between the value of GaTT and THPR was revealed in patients with LC, but not in OJ. These results suggested that liver dysfunction in OJ was independent of the decreased number of hepatocytes, differing from LC.
Kaiho
T
T
First Department of Surgery, School of Medicine, Chiba University, Japan.
Miyazaki
M
M
Ito
H
H
Ambiru
S
S
Shimizu
H
H
Togawa
A
A
Ohtsuka
M
M
Shiobara
M
M
Shimizu
Y
Y
Sasada
K
K
Yoshioka
S
S
Yoshidome
H
H
Nakajima
N
N
D000328:Adult; D000368:Aged; D002779:Cholestasis / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D005690:Galactose / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000503:physiopathology*; D008103:Liver Cirrhosis / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged
D005690:Galactose