Effect of corticosterone on serotonin and catecholamine receptors and uptake sites in rat frontal cortex.
The effects of corticosterone (1 mg/kg per day for 7 days) on serotonin 5-HT1A, 5-HT2A, 5-HT uptake sites, and alpha 2-adrenergic receptor sites were measured. Corticosterone treatment significantly decreased the number of 5-HT1A receptor sites (Bmax = 108 +/- 8.20 fmol/mg protein and 152.31 +/- 13.36 fmol/mg protein in corticosterone- and vehicle-treated rats, respectively). No significant differences were found in other measures. It is possible that corticosteroids exert some of their behavioral effects via regulation of 5-HT1A sites in frontal cortex.
Crayton
J W
JW
Biological Psychiatry Laboratories (116A7), Hines VA Hospital, IL 60141, USA.
Joshi
I
I
Gulati
A
A
Arora
R C
RC
Wolf
W A
WA
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D003345:Corticosterone / Q000494:pharmacology*; D005625:Frontal Lobe / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017983:Receptors, Catecholamine / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000187:drug effects*
D017983:Receptors, Catecholamine; D011985:Receptors, Serotonin; D003345:Corticosterone