DNA quantification as a prognostic factor in prostatic adenocarcinoma.
OBJECTIVE
To determine if DNA quantification on fine needle aspiration (FNA) has a predictive value in cancer of the prostate.


METHODS
Fifty-four patients with cancer of the prostate during the years 1979-1989 were selected; all were diagnosed by FNA. The smears were studied using image cytometry.


RESULTS
With the type of histogram and value of entropy, two large groups with high and low degrees of malignancy were obtained. Survival was utilized as a variable of interest. Kaplan-Meier survival curves for both groups were formulated, and the results were supported with statistical data.


CONCLUSIONS
The survival differences between both groups were statistically significant (P < .001), thus demonstrating the predictive value of DNA quantification.
Azúa
J
J
Department of Morphologic Sciences, Faculty of Medicine, University of Zaragoza, Spain.
Romeo
P
P
Valle
J
J
Azúa
J
J
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis*; D006801:Humans; D019044:Image Cytometry; D008297:Male; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology
D004273:DNA, Neoplasm