[Intraoperative use of plasma-derived activated factor VII (F VII a) in a hemophilia A patient with inhibitors].
We treated a 1-year 9-month-old boy with severe hemophilia A who developed high level of F VIII inhibitor. A placement of an implantable intravenous access device was scheduled under general anesthesia. After a slow induction using oxygen, nitrous oxide and sevoflurane, a peripheral venous line was placed and plasma-derived F VII a was infused. A catheter was inserted via the jugular vein to the SVC and it was connected to the device placed subcutaneously in his right chest wall. The peroperative blood loss was slight, and anesthesia and surgery went uneventfully.
Matsuyama
K
K
Department of Anesthesiology, Kumamoto University School of Medicine.
Ushijima
K
K
Kano
T
T
Tsuchiya
H
H
D000768:Anesthesia, General; D000917:Antibody Formation; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D015942:Factor VIIa / Q000008:administration & dosage*; D006467:Hemophilia A / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007223:Infant; D007430:Intraoperative Care; D008297:Male; D014947:Wounds and Injuries / Q000601:surgery
D005169:Factor VIII; D015942:Factor VIIa