Effect of aging on the spatial learning deficit produced by diazepam in rats.
1. After pretraining in an undrugged state, young (6 months) and aged (18-24 months) rats were trained on a spatial learning-set task after receiving one of four doses of diazepam (1, 2, 3 or 5 mg/kg) or the drug vehicle. The effects of 5 mg/kg of diazepam were also assessed on the spatial learning-set task one full hour after injection (delay condition) as well as on the visible platform task. 2. During pretraining (undrugged), aged rats demonstrated a transient impairment on the visible platform task but subsequently did not differ significantly from young rats on the submerged platform task. On the spatial learning-set task, aged rats performed as well as young rats under control conditions and diazepam produced a comparable dose-dependent impairment of spatial learning. However, when the 1 hr delay was interposed between diazepam administration and maze testing, only aged rats exhibited a spatial learning impairment. Diazepam did not impair performance on the visible platform task in either young or aged rats. 3. These results indicate that although the amnesic effect of diazepam is not initially greater in aged rats, it persists for longer periods.
McNamara
R K
RK
University of Florida, Department of Psychiatry, Gainesville, USA.
Davis
T M
TM
Skelton
R W
RW
D000375:Aging / Q000523:psychology*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D003463:Cues; D003975:Diazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D018782:Maze Learning / Q000187:drug effects* / Q000502:physiology*; D051381:Rats; D012193:Reversal Learning / Q000187:drug effects; D013028:Space Perception / Q000187:drug effects* / Q000502:physiology*
D014151:Anti-Anxiety Agents; D003975:Diazepam