title: Diffuse sclerosing osteomyelitis of the mandible: its characteristics and possible relationship to synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome.
abstract: OBJECTIVE
  This article reports on the possible relationship of diffuse sclerosing osteomyelitis (DSO) of the mandible to synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome.
  
  
  METHODS
  The pathologic features in 12 new DSO patients and those in previously reported cases were reviewed and compared with those of SAPHO syndrome.
  
  
  RESULTS
  Many similarities were noted between the two entities in terms of the clinical, radiographic, and histologic features. Furthermore, multiple bone lesions and skin lesions (palmoplantar pustulosis and psoriasis) were observed not only in SAPHO syndrome but also in DSO patients.
  
  
  CONCLUSIONS
  DSO is concluded to be one manifestation of SAPHO syndrome.
authors.affiliation: Department of Oral and Maxillofacial Radiology, Hiroshima University, School of Dentistry, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Suei
authors.forename: A
authors.initials: A
authors.lastname: Taguchi
authors.forename: K
authors.initials: K
authors.lastname: Tanimoto
mesh_terms: D000152:Acne Vulgaris / Q000473:pathology; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015576:Hyperostosis / Q000473:pathology; D008297:Male; D008336:Mandibular Diseases / Q000145:classification* / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D010000:Osteitis / Q000473:pathology; D010019:Osteomyelitis / Q000145:classification / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D011565:Psoriasis / Q000473:pathology; D011859:Radiography; D013577:Syndrome; D013585:Synovitis / Q000473:pathology