Evidence for the promoting role of the intra-uterine kinin release in the development of late hypertonic saline-induced abortion.
Blood plasma kininogen (K), kininases (KS), kallikrein (KK), prekallikrein (PKK), and PGF2a were estimated in the common circulation of pregnant women during late saline-induced abortion and also in retroplacental blood after foetus delivery. The results provide evidence for intra-uterine kinin release from circulating blood K by locally activated KK from the very beginning of abortion. The greatest kinin release coincided with the strongest KS activity decrease at the time of foetus delivery. The pre-abortive KS levels correlated directly with abortus duration. Uterine PG biosynthesis was activated, but appeared to be a secondary process.
Makevnina
L G
LG
Institute of Biomedical Chemistry, Moscow, Russia.
Nikonov
A P
AP
Goncharova
V N
VN
Morozova
M S
MS
Paskhina
T S
TS
D000028:Abortion, Induced / Q000379:methods*; D015237:Dinoprost / Q000097:blood; D005260:Female; D006801:Humans; D016234:Kallikrein-Kinin System / Q000502:physiology; D007610:Kallikreins / Q000378:metabolism; D007704:Kininogens / Q000097:blood; D007705:Kinins / Q000378:metabolism*; D001121:Lysine Carboxypeptidase / Q000097:blood; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D011247:Pregnancy; D011255:Pregnancy Maintenance / Q000502:physiology; D011262:Pregnancy Trimester, Second; D011288:Prekallikrein / Q000378:metabolism; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage
D007704:Kininogens; D007705:Kinins; D012462:Saline Solution, Hypertonic; D011288:Prekallikrein; D015237:Dinoprost; D007703:Peptidyl-Dipeptidase A; D001121:Lysine Carboxypeptidase; D007610:Kallikreins