Soluble receptors for cytokines and growth factors.
Soluble cytokine and growth factor receptors are currently believed to play an important role in the regulation of biological activities of their ligands. In this review, the current ideas on the mechanisms and regulation of generation of soluble receptors and their possible physiological functions are presented. Furthermore, implications of soluble cytokine and growth factor receptors as disease markers and therapeutical agents are summarized and discussed.
Müller-Newen
G
G
Institut für Biochemie, RWTH Aachen, Deutschland.
Köhne
C
C
Heinrich
P C
PC
D017398:Alternative Splicing; D015415:Biomarkers; D004358:Drug Therapy; D006801:Humans; D018121:Receptors, Cytokine / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000502:physiology*; D017978:Receptors, Growth Factor / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000502:physiology*
D015415:Biomarkers; D018121:Receptors, Cytokine; D017978:Receptors, Growth Factor