Antidepressant-like effects of p-synephrine in mouse models of immobility tests.
We studied the effects of p-synephrine on the immobility behaviors and on the spontaneous motor activity in mice. p-Synephrine at oral doses from 1 to 10 mg/kg significantly decreased the duration of immobility in the tail suspension test and the forced swimming test in mice. At 30 mg/kg, the duration of immobility was returned to control values in both tests. Subcutaneous administration of prazosin hydrochloride (62.5 micrograms/kg), an alpha 1 adrenoceptor antagonist, blocked the p-synephrine (3 mg/kg)-induced decrease in immobility in the tail suspension test. p-Synephrine did not change the spontaneous motor activity at oral doses from 0.3 to 10 mg/kg. These results suggest that p-synephrine elicits an antidepressant-like activity in mouse models of immobility tests, through the stimulation of alpha 1 adrenoceptors.
Song
D K
DK
Department of Pharmacology, College of Medicine, Hallym University, Chunchon, Kangwon-Do, South Korea. dksong@sun.hallym.ac.kr
Suh
H W
HW
Jung
J S
JS
Wie
M B
MB
Son
K H
KH
Kim
Y H
YH
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000037:antagonists & inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D003863:Depression / Q000523:psychology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D011224:Prazosin / Q000494:pharmacology; D013578:Synephrine / Q000037:antagonists & inhibitors / Q000302:isolation & purification / Q000494:pharmacology*
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D000928:Antidepressive Agents; D013578:Synephrine; D011224:Prazosin