title: Respiratory tract disease and mucosal colonization by Pasteurella haemolytica in transported cattle.
abstract: OBJECTIVE
  To follow incidence of Pasteurella haemolytica (PH) in the upper respiratory tract of healthy calves at the farm and through the marketing process, and to determine the effect of vaccination on PH colonization of the upper respiratory tract and on the incidence of respiratory tract disease (RTD).
  
  
  METHODS
  2- to 5-month-old calves (n = 104) from 4 farms.
  
  
  METHODS
  Calves were vaccinated with a killed PH serotype-1 product. Nasal secretion and tonsil wash specimens were cultured for PH, and serum antibody was measured by indirect hemagglutination. Calves with RTD were treated with tilmicosin phosphate.
  
  
  RESULTS
  At the feedyard, 73 calves had RTD. The incidence of RTD was significantly related to the farm of origin, and was inversely related to the PH serum titer at the farm, but was not influenced by vaccination. Isolations of PH serotype 1, however, were reduced by vaccination. The major serotypes of PH encountered were 1 and 6.
  
  
  CONCLUSIONS
  Vaccination can reduce the frequency of colonization of the upper respiratory tract by PH.
authors.affiliation: USDA-ARS, National Animal Disease Center, Ames, IA 50010, USA.
authors.forename: G H
authors.initials: GH
authors.lastname: Frank
authors.forename: R E
authors.initials: RE
authors.lastname: Briggs
authors.forename: R W
authors.initials: RW
authors.lastname: Loan
authors.forename: C W
authors.initials: CW
authors.lastname: Purdy
authors.forename: E S
authors.initials: ES
authors.lastname: Zehr
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines; D002417:Cattle; D002418:Cattle Diseases; D006386:Hemagglutination Tests; D015994:Incidence; D008297:Male; D016978:Mannheimia haemolytica / Q000145:classification / Q000302:isolation & purification; D009297:Nasal Mucosa / Q000382:microbiology*; D009919:Orchiectomy; D010326:Pasteurella Infections / Q000453:epidemiology / Q000276:immunology / Q000662:veterinary*; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000276:immunology / Q000662:veterinary*; D013714:Tennessee / Q000453:epidemiology; D014611:Vaccination
chemical_list: D001428:Bacterial Vaccines