title: [Two cases of Candida endocarditis associated with abdominal disease].
abstract: Two cases of Candida endocarditis are reported. The first case was of a 63-year-old man who had a positive blood culture for Candida albicans during treatment for liver abscess and early gastric cancer. He was transferred to our department, and aortic and tricuspid regurgitation due to Candida endocarditis was diagnosed. The patient was successfully treated with aortic valve replacement, tricuspid valve plasty and anti-fungal agents. The second case was of a 65-year-old man who complained of fever. Despite a diagnosis of common bile duct cancer and resection of the tumor, the fever persisted. He was transferred to our department and was diagnosed having aortic regurgitation due to Candida endocarditis, complicated by heart failure. Although intense medical therapy including antifungal agents, diuretics, catecholamines and digoxin was initiated, the patient died from multiple embolisms 9 days later. In the treatment of Candida endocarditis, early diagnosis and early decision-making for either surgical or medical therapy is indispensable. Although the prevalence of Candida endocarditis is low, the differentiation of this disease should be taken into account in febrile elderly patients with long-standing therapy with antibiotics.
authors.affiliation: Department of Medicine and Geriatrics, Kochi Medical School.
authors.forename: Y
authors.initials: Y
authors.lastname: Hamada
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: T
authors.initials: T
authors.lastname: Furuno
authors.forename: C
authors.initials: C
authors.lastname: Fujii
authors.forename: Y
authors.initials: Y
authors.lastname: Matsumura
authors.forename: T
authors.initials: T
authors.lastname: Yabe
authors.forename: H
authors.initials: H
authors.lastname: Seo
authors.forename: J
authors.initials: J
authors.lastname: Takata
authors.forename: T
authors.initials: T
authors.lastname: Chikamori
authors.forename: Y
authors.initials: Y
authors.lastname: Doi
mesh_terms: D000368:Aged; D002177:Candidiasis / Q000150:complications*; D004067:Digestive System Neoplasms / Q000150:complications*; D004696:Endocarditis / Q000150:complications*; D005335:Fever of Unknown Origin / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged