Tyrphostins IV--highly potent inhibitors of EGF receptor kinase. Structure-activity relationship study of 4-anilidoquinazolines.
Potent 4-anilido-substituted quinazolines which potently inhibit epidermal growth factor receptor (EGFR) kinase were prepared. Structure-activity relationship studies reveal high sensitivity to substitution at the aniline ring.
Gazit
A
A
Department of Organic Chemistry, Alexander Silverman Institute of Life Sciences, Hebrew University of Jerusalem, Israel.
Chen
J
J
App
H
H
McMahon
G
G
Hirth
P
P
Chen
I
I
Levitzki
A
A
D000814:Aniline Compounds / Q000737:chemistry*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors*; D010766:Phosphorylation; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D011799:Quinazolines / Q000737:chemistry*; D019311:Staurosporine / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000814:Aniline Compounds; D011799:Quinazolines; D066246:ErbB Receptors; D011493:Protein Kinase C; D019311:Staurosporine; C023650:aniline