t(9;13)(q34;q12) chromosomal translocation persisting 4 years post autologous bone marrow transplantation for secondary AML despite morphological remission.
A 42-year-old male patient with a history of occupational exposure to benzene presented with pancytopenia. His bone marrow showed evidence of trilineage dysplasia and cytogenetic analysis revealed a unique t(9;13)(q34;q12) translocation. Five months after diagnosis he developed secondary AML. He was treated with four courses of chemotherapy and an autologous bone marrow transplantation (BMT). Four years post-transplantation he remains in haematological and morphological remission though the cytogenetic abnormality is still present in all metaphases examined.
Mahendra
P
P
Department of Haematology, Addenbrooke's NHS Trust, Cambridge, UK.
Richards
E M
EM
Sinclair
P
P
Nacheva
E
E
Marcus
R E
RE
D000208:Acute Disease; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001554:Benzene / Q000009:adverse effects*; D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation; D002330:Carmustine / Q000008:administration & dosage; D002882:Chromosomes, Human, Pair 13 / Q000648:ultrastructure*; D002899:Chromosomes, Human, Pair 9 / Q000648:ultrastructure*; D003131:Combined Modality Therapy; D005047:Etoposide / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D007951:Leukemia, Myeloid / Q000139:chemically induced / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D009190:Myelodysplastic Syndromes / Q000139:chemically induced / Q000150:complications / Q000235:genetics* / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000473:pathology; D009784:Occupational Diseases / Q000139:chemically induced / Q000150:complications*; D016273:Occupational Exposure; D010198:Pancytopenia / Q000209:etiology; D012074:Remission Induction; D012997:Solvents / Q000009:adverse effects*; D014178:Translocation, Genetic; D014184:Transplantation, Homologous
D012997:Solvents; D005047:Etoposide; D001554:Benzene; D008558:Melphalan; D002330:Carmustine