title: Effect of caffeine coadministration and of nitric oxide synthesis inhibition on the antinociceptive action of ketorolac.
abstract: The effects of caffeine and nitric oxide synthesis inhibition on the antinociceptive action of ketorolac were assessed using the pain-induced functional impairment model in the rat. Nociception was induced by the intra-articular injection of uric acid. Ketorolac, but not caffeine, produced an antinociceptive effect which was reduced by NG nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthesis. Caffeine coadministration potentiated the ketorolac effect. L-NAME induced a dose-dependent reduction of this potentiation. The results suggest the participation of the L-arginine-nitric oxide-cyclic GMP pathway in the caffeine potentiation of ketorolac-induced antinociception.
authors.affiliation: Departamento de Farmacología y Toxicologia, Estudios Avanzados del Instituto Politécnico Nacional, Apartado, México, D.F., Mexico.
authors.forename: F J
authors.initials: FJ
authors.lastname: López-Muñoz
authors.forename: G
authors.initials: G
authors.lastname: Castañeda-Hernández
authors.forename: F J
authors.initials: FJ
authors.lastname: Flores-Murrieta
authors.forename: V
authors.initials: V
authors.lastname: Granados-Soto
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D002110:Caffeine / Q000008:administration & dosage / Q000494:pharmacology*; D004357:Drug Synergism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D020910:Ketorolac; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D051381:Rats; D017208:Rats, Wistar; D014046:Tolmetin / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000700:Analgesics; D004791:Enzyme Inhibitors; D009569:Nitric Oxide; D002110:Caffeine; D014046:Tolmetin; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester; D020910:Ketorolac