title: Phagocytosis of Helicobacter pylori bacteria differing in the heparan sulfate binding by human polymorphonuclear leukocytes.
abstract: Heparan sulfate binding proteins (HSBPs) of Helicobacter pylori facilitate bacterial phagocytosis by human polymorphonuclear leukocytes (PMNs). H. pylori 25 strain which demonstrates a strong heparan sulfate binding activity was found to be attached to/ingested by PMNs in greater numbers than H. pylori strain 17874 bacteria which lacked this activity. Moreover, heparin inhibited the uptake of cells of H. pylori strain 25 but not of cells of H. pylori strain 17874 by PMNs.
authors.affiliation: Department of Infectious Biology, University of Lodz, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Chmiela
authors.forename: A
authors.initials: A
authors.lastname: Ljungh
authors.forename: W
authors.initials: W
authors.lastname: Rudnicka
authors.forename: T
authors.initials: T
authors.lastname: Wadstrom
mesh_terms: D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000032:analysis*; D002352:Carrier Proteins / Q000032:analysis*; D016480:Helicobacter pylori / Q000276:immunology*; D006497:Heparan Sulfate / Q000378:metabolism*; D006801:Humans; D009504:Neutrophils / Q000382:microbiology*; D010587:Phagocytosis; D013045:Species Specificity
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D006497:Heparan Sulfate; C082315:GAG-BP protein, Streptococcus pyogenes