Translocation t(3;17)(q23;q21): a new translocation in acute lymphoblastic leukaemia.
We report on two adult patients with CD10+ positive acute lymphoblastic leukaemia (ALL) who presented with similar clinical and laboratory features and with a new chromosomal translocation: t(3;17)(q23;q21). This translocation may be involved in the formation of a new chimaeric transcription factor. Both patients shared several poor prognostic factors at presentation and an adverse clinical course. The t(3;17)(q23;q21) translocation may therefore predict a poor outcome in ALL.
Raanani
P
P
Institute of Haematology, Chaim Sheba Medical Centre, Tel-Hashomer, Israel.
Berkowicz
M
M
Rosner
E
E
Rosenthal
E
E
Berman
S
S
Rechavi
G
G
Ben-Bassat
I
I
D000328:Adult; D002886:Chromosomes, Human, Pair 17; D002893:Chromosomes, Human, Pair 3; D017809:Fatal Outcome; D005801:Genes, Homeobox; D006801:Humans; D007621:Karyotyping; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D014178:Translocation, Genetic