title: Donor factors associated with epithelial defects after penetrating keratoplasty.
abstract: The records of 39 patients undergoing 40 consecutive penetrating keratoplasties were reviewed to identify donor factors that might correlate with the presence of an epithelial defect on the first postoperative day. Of the 40 transplanted corneas, 13 (32.5%) had no epithelial defect, 18 (45%) had some epithelial defect, and nine (22.5%) had a total epithelial defect 1 day postoperatively. The status of the epithelium was correlated with several donor factors. The only factor that had a statistically significant association with the degree of epithelial defect was the time interval from preservation to surgery (p = .001). Based on a logistic regression model, the probability of having an epithelial defect 1 day after penetrating keratoplasty increased with respect to longer storage times. These results may aid the surgeon in the selection of donor tissue, particularly when performing penetrating keratoplasty on patients with ocular surface disorders.
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: T
authors.initials: T
authors.lastname: Kim
authors.forename: D A
authors.initials: DA
authors.lastname: Palay
authors.forename: M
authors.initials: M
authors.lastname: Lynn
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002809:Chondroitin Sulfates; D045424:Complex Mixtures; D003315:Cornea / Q000473:pathology*; D003316:Corneal Diseases / Q000209:etiology* / Q000473:pathology; D016895:Culture Media, Serum-Free; D003911:Dextrans; D004848:Epithelium / Q000473:pathology; D005260:Female; D005839:Gentamicins; D006801:Humans; D015948:Keratoplasty, Penetrating / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009926:Organ Preservation; D011183:Postoperative Complications / Q000209:etiology* / Q000473:pathology; D012307:Risk Factors; D013997:Time Factors; D014019:Tissue Donors
chemical_list: D045424:Complex Mixtures; D016895:Culture Media, Serum-Free; D003911:Dextrans; D005839:Gentamicins; D002809:Chondroitin Sulfates; C075736:Optisol