title: Impact of fluorodeoxyglucose positron emission tomography on the clinical management of patients with glioma.
abstract: The past decade has seen the identification of many clinical settings in the treatment of primary brain tumors in which information from fluorodeoxyglucose positron emission tomography (FDG-PET) might be useful, if not essential, to therapeutic formulation. FDG-PET is currently used at referral centers in the management of primary brain tumors. The clinical pattern of FDG-PET use was assessed and its value compared to other information sources in clinical decision making. The clinical records of 75 glioma patients who were evaluated by FDG-PET were reviewed. The range of circumstances in which FDG-PET was employed included: pretherapeutic baseline studies for monitoring the effect of a therapy (1% of all cases), mapping of hypermetabolic regions before surgery or biopsy (2%), mapping of hypermetabolic regions before radiotherapy (2%), postsurgical evaluation for residual tumor (2%), assessment of the malignancy of a mass as a substitute for biopsy (11%), and distinguishing between radiation necrosis and recurrent tumor (87%). Other sources of information that contributed to the therapeutic management of patients included: gadolinium-enhanced MRI, contrast-CT, and clinical findings.
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Boston 02114, USA.
authors.forename: A
authors.initials: A
authors.lastname: Deshmukh
authors.forename: J A
authors.initials: JA
authors.lastname: Scott
authors.forename: E L
authors.initials: EL
authors.lastname: Palmer
authors.forename: F H
authors.initials: FH
authors.lastname: Hochberg
authors.forename: M
authors.initials: M
authors.lastname: Gruber
authors.forename: A J
authors.initials: AJ
authors.lastname: Fischman
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000528:radiation effects; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D003847:Deoxyglucose / Q000031:analogs & derivatives*; D003937:Diagnosis, Differential; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005910:Glioma / Q000000981:diagnostic imaging* / Q000628:therapy; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D011832:Radiation Injuries / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose