Diagnosis of an anemone cell tumor as a B-cell lymphoma by molecular analysis.
An 83-year-old man presented with mediastinal and axillary lymphadenopathy. Immunophenotyping and electron microscopy performed on an excision biopsy were inconclusive. On a repeat biopsy a year later the ultrastructural features typical of an anemone cell tumor were seen. A panel of monoclonal antibodies showed positivity for vimentin only. The diagnosis of a high-grade B-cell lymphoma could be made only after detection of immunoglobulin gene rearrangement by polymerase chain reaction gene amplification.
Blakolmer
K
K
Department of Anatomical Pathology, University of Cape Town Medical School, Republic of South Africa.
Essop
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D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000648:ultrastructure; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000235:genetics / Q000648:ultrastructure*; D008297:Male; D016133:Polymerase Chain Reaction