Gene therapy for ischemic heart disease.
Gene therapy techniques are being developed as potential treatments for dyslipidemias, coronary restenosis, and vein graft disease. Retroviral and now adenoviral gene delivery techniques are being studied. A human protocol for the treatment of familial hypercholesterolemia has recently been completed using ex vivo hepatic low-density lipoprotein receptor gene transfer via a retroviral vector. Work in most other areas is currently in the animal model stage. Significant progress has been made in the area of coronary restenosis, particularly in identifying target genes to reduce neointima formation, such as herpesvirus thymidine kinase and the retinoblastoma gene. Work also continues in developing strategies to decrease neointima formation in vein grafts used in coronary bypass surgery and in improving methods of myocardial protection during surgery.
Malosky
S
S
Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
Kolansky
D M
DM
D000818:Animals; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000628:therapy; D015316:Genetic Therapy; D006083:Graft Occlusion, Vascular / Q000628:therapy; D006801:Humans; D006949:Hyperlipidemias / Q000628:therapy; D017202:Myocardial Ischemia / Q000628:therapy*; D016376:Oligonucleotides, Antisense / Q000627:therapeutic use; D012008:Recurrence
D016376:Oligonucleotides, Antisense