In-vitro activity of ofloxacin, levofloxacin and D-ofloxacin against staphylococci.
The in-vitro activity of levofloxacin was compared with ofloxacin and D-ofloxacin against 130 isolates of Staphylococcus aureaus and 117 isolates of coagulase-negative staphylococci, using the agar dilution method. In general, levofloxacin was equally active or up to fourfold more active than ofloxacin against all staphylococci, including 61 methicillin-resistant S. aureus. In contrast, D-ofloxacin showed little activity against all isolates tested.
von Eiff
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Institute of Medical Microbiology, Westfälische Wilhelms-Universität Münster, Germany.
Peters
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G
D000890:Anti-Infective Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology*; D013210:Staphylococcus / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013237:Stereoisomerism
D000890:Anti-Infective Agents; D064704:Levofloxacin; D015242:Ofloxacin