Effects of a new oxazolidinone derivative AS-8 on serotonin metabolism in the brains of mouse, rat and chick.
The effect of 5-morpholinemethyl-3-(4-chlorobenzylideneamino)-2-oxazolidin one (AS-8), a potential antidepressant drug, was tested on 5-hydroxytryptamine (5-HT) metabolism in the brains of rat, mouse and chick. The ip administration of AS-8 (25-500 mg/kg) did not modify the cerebral 5-HT level, but significantly increased the level of 5-hydroxyindoleacetic acid (5-HIAA) the main 5-HT metabolite. In animals receiving pargyline (a MAO-A inhibitor which blocks 5-HT catabolism), AS-8 markedly enhanced 5-HT accumulation in the brains of rats and mice, but not chicks. It is concluded that AS-8 is capable of stimulating of 5-HT synthesis at least in the mammalian brain.
Chilmonczyk
Z
Z
Pharmaceutical Research Institute, Warszawa, Poland.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects*; D002645:Chickens; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D051379:Mice; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009025:Morpholines / Q000494:pharmacology*; D010080:Oxazoles / Q000494:pharmacology*; D023303:Oxazolidinones; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors
C090700:AS 8; D000928:Antidepressive Agents; D008996:Monoamine Oxidase Inhibitors; D009025:Morpholines; D010080:Oxazoles; D023303:Oxazolidinones; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D010293:Pargyline