title: Sustained-release subconjunctival 5-fluorouracil.
abstract: OBJECTIVE
  The purpose of this research was to obtain preliminary safety and efficacy data on a novel sustained-release 5-fluorouracil (5-FU) implant in high-risk glaucoma surgical patients.
  
  
  METHODS
  The implants were placed subconjunctivally in four patients undergoing high-risk trabeculectomy. The patients have been observed for approximately 2.5 years.
  
  
  RESULTS
  In three of the four patients intraocular pressure was controlled at less than 21 mm Hg, with stabilization of the visual field. One patient had early failure. No untoward events were linked to the placement of the implant.
  
  
  CONCLUSIONS
  Sustained-release systems for subconjunctival 5-FU may be useful in filter maintenance.
authors.affiliation: Department of Ophthalmology, University of Kentucky, Lexington, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Smith
authors.forename: P
authors.initials: P
authors.lastname: Ashton
mesh_terms: D000368:Aged; D000963:Antimetabolites / Q000008:administration & dosage*; D003228:Conjunctiva; D003692:Delayed-Action Preparations; D004343:Drug Implants; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D011183:Postoperative Complications / Q000503:physiopathology / Q000517:prevention & control*; D014130:Trabeculectomy; D014792:Visual Acuity
chemical_list: D000963:Antimetabolites; D003692:Delayed-Action Preparations; D004343:Drug Implants; D005472:Fluorouracil