Markers of melanogenesis in malignant melanoma.
Biochemical specifity of malignant melanoma is represented in part by the formation of specific cytoplasmatic particles of the pigment cell--melanosomes--in which the synthesis of pigment eumelanin and pheomelanin takes place and in part by the presence of a specific enzyme--tyrosinase--which catalyzes the formation of pigment eumelanin and pheomelanin and even the formation of specific metabolites (so called melanogens) which are excreted in increased amounts in the course of the disease. Tyrosinase and melanogens are specific for pigment cell and therefore can be used for monitoring of melanogenesis in malignant melanoma. When comparing our results and the results of other authors we can conclude that following of specific markers of melanogenesis in malignant melanoma should serve for the evaluation of prognosis of the disease. The study of melanoma markers is by far not finished. We do hope that nearly future will be able to give a sufficient answer to the question, whether melanogenuria is actually an expression of expected different biochemical or metabolic types of malignant melanoma on the one hand and/or biochemically or immunologically conditioned responses of the host organism on the other.
Matous
B
B
2nd Department of Medical Chemistry and Biochemistry, Charles University, Praha, Czech Republic.
Bubnova
E
E
Budesinska
A
A
Kostirova
M
M
D014408:Biomarkers, Tumor / Q000652:urine; D006801:Humans; D008543:Melanins / Q000096:biosynthesis* / Q000652:urine; D008545:Melanoma / Q000378:metabolism* / Q000652:urine; D011379:Prognosis; D012878:Skin Neoplasms / Q000378:metabolism* / Q000652:urine
D014408:Biomarkers, Tumor; D008543:Melanins; C018362:pheomelanin; C041877:eumelanin