Cardiac effects of methylmethacrylate in the rat heart-lung preparation with or without volatile anesthetics.
We have assessed the deleterious effects of methylmethacrylate (MMA) on cardiac function and metabolism in the isolated heart-lung preparation with or without volatile anesthetics. Wistar rats were prepared for the heart-lung model. They were randomly divided into 5 groups as follows. (1) Control (C) group. (2) Cement (M) group; they received MMA. (3) Halothane (H) group; they received MMA and 1% halothane. (4) Isoflurane (I) group; they received MMA and 1.5% isoflurane. (5) Sevoflurane (S) group; they received MMA and 2.5% sevoflurane. MMA 1000 micrograms/ml was administered 7 min after the start of perfusion except in the C group. At the end of the experimental period, the hearts were freeze-clamped and then myocardial high energy phosphates, lactate and glycogen were measured. Cardiac output in all groups but C group decreased significantly. PO2 of the perfusion blood in the M, H, I and S groups was significantly lower than that in the C group. Myocardial ATP in the M, H, I and S groups was significantly lower than that in the C group. ADP and AMP in the M, H, I and S groups were higher than those in the C group. There were no significant differences in lactate and glycogen levels between the 5 groups. MMA 1000 micrograms/ml is much higher than the blood level (0.05-31.89 micrograms/ml) which was reported in clinical patients who had femoral prosthesis. Therefore, the direct contribution of MMA itself to cardiac depression may be less than the other factors such as embolism in clinical situations. Volatile anesthetics did not influence the deleterious effects of MMA on cardiac function and metabolism.
Kashimoto
S
S
Department of Anesthesiology, Yamanashi Medical University, Japan.
Nakamura
T
T
Furuya
A
A
Nonaka
A
A
Matsukawa
T
T
Kumazawa
T
T
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D006333:Heart Failure / Q000139:chemically induced; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects*; D008297:Male; D020366:Methylmethacrylate; D008768:Methylmethacrylates / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D000777:Anesthetics; D008768:Methylmethacrylates; D010710:Phosphates; D020366:Methylmethacrylate