title: Both the H13 gene product and 4F2 antigen are involved in the induction of system y+ cationic amino-acid transport following activation of human peripheral blood mononuclear cells (PBM).
abstract: Prior transfection with antisense oligonucleotides to the H13 and 4F2 hc genes, singly or in combination, was found to inhibit phytohaemagglutinin-induced activation of cationic amino-acid transport system y+ in human peripheral blood mononuclear cells (mostly circulating lymphocytes). These effects on system y+ function or expression mean that 4F2 hc cannot only be the molecular basis of system y+L (Fei, Y.-J., Prasad, P.D., Leibach, F.H. and Ganapathy, V. (1995) Biochemistry 34, 8744-8751).
authors.affiliation: Department of Human Anatomy, University of Oxford, UK.
authors.forename: S
authors.initials: S
authors.lastname: Chen
authors.forename: D
authors.initials: D
authors.lastname: Meredith
authors.forename: C A
authors.initials: CA
authors.lastname: Boyd
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D015703:Antigens, CD / Q000235:genetics* / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D002478:Cells, Cultured; D027261:Fusion Regulatory Protein-1; D005786:Gene Expression Regulation; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008213:Lymphocyte Activation / Q000235:genetics*; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D011991:Receptors, Virus
chemical_list: D000596:Amino Acids; D015703:Antigens, CD; D002352:Carrier Proteins; D027261:Fusion Regulatory Protein-1; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011991:Receptors, Virus; C070506:ecotropic murine leukemia virus receptor