Diffuse large cell lymphoma of B-cell type associated with reactive hemophagocytosis.
Some lymphomas, virtually all phenotypically of the T-cell type, have been associated with the phenomenon of hemophagocytosis. Only two B-cell lymphomas, one T-cell-rich and the other an angiocentric lymphoma, have been observed to exhibit this phenomenon. A case is reported of a diffuse large cell lymphoma of the B-cell type associated with reactive hemophagocytosis. Cytokines or other humoral factors produced by the lymphoma are a possible cause, and their effect is probably systemic. There is some evidence suggesting correlation of hemophagocytosis with tumor aggressiveness.
Aung
W
W
Department of Pathology, Veteran Affairs Medical Center, Brooklyn, NY 11203, USA.
Koslosky
W
W
Chin
N W
NW
Pincus
M R
MR
D000328:Adult; D015415:Biomarkers; D001773:Blood Cells; D001853:Bone Marrow / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D010587:Phagocytosis; D013154:Spleen / Q000473:pathology
D015415:Biomarkers