title: Association between Wegener's granulomatosis and Staphylococcus aureus infection?
abstract: Two patients are presented with Wegener's granulomatosis (WG) and lower respiratory tract infections with Staphyloccus aureus (SA). It is posulated that there is a relationship between the infection and the induction or relapse of the disease. We suggest that bronchoalveolar lavages should be performed in cases of suspected WG to identify SA-infections. The co-existence of WG and SA support the reported beneficial effects of sulfamethoxazole/trimethoprim, but needs further evaluation in patients with and without SA-infection of the airways.
authors.affiliation: University Hospital, Dept of Pulmonary Medicine, Utrecht, The Netherlands.
authors.forename: J W
authors.initials: JW
authors.lastname: van Putten
authors.forename: E H
authors.initials: EH
authors.lastname: van Haren
authors.forename: J W
authors.initials: JW
authors.lastname: Lammers
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D015169:Colony Count, Microbial; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D008875:Middle Aged; D009666:Nose / Q000382:microbiology; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000150:complications* / Q000188:drug therapy; D013183:Sputum / Q000382:microbiology; D013203:Staphylococcal Infections / Q000150:complications* / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000302:isolation & purification; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination