Influence of eticlopride on cocaine- and DA D2 agonist-induced behavioral effects in rats.
The influence of the DA D2 antagonist (-) eticlopride on cocaine- and DA D2 agonist-induced behavioral effects was investigated by means of two series of experiments, in rats. In the first 10-day series, coadministration of (-) eticlopride (10 and 50 micrograms/kg, SC) always potently inhibited cocaine (15 mg/kg, IP)-induced hypermotility but did not modify the penile erection (PE)-enhancement produced by the drug at the first injection; it actually counteracted the inhibitory effect of subchronic cocaine on PE. In the second series, (-) eticlopride, at the same doses, antagonized PE elicited by various DA D2 agonists at nonstereotyping doses; when, along with PE, stereotyped behavior was induced, only the latter was inhibited by (-) eticlopride, which even increased PE.
Ferrari
F
F
Department of Biomedical Sciences, University of Modena, Italy.
Giuliani
D
D
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003042:Cocaine / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010410:Penile Erection / Q000187:drug effects*; D051381:Rats; D012457:Salicylamides / Q000494:pharmacology*; D012726:Sexual Behavior, Animal / Q000187:drug effects; D013997:Time Factors
D018492:Dopamine Antagonists; D012457:Salicylamides; D003042:Cocaine; C045989:eticlopride