title: Characterization of the conditioned taste aversion produced by 7-OH-DPAT in rats.
abstract: Using the conditioned taste aversion preparation, we described the dose-effect curve for the reputed dopamine D3 agonist (+/-)7-OH-DPAT (0, 0.001, 0.01, 0.1, 1.0, or 10 mg/kg). Rats received a 0.1% saccharin taste paired on repeated occasions with one of the 7-OH-DPAT doses. The 0.1, 1.0, and 10.0 mg/kg doses of 7-OH-DPAT produced a significant conditioned saccharin aversion. This aversion was evident regardless of whether saccharin intake of 7-OH-DPAT-treated rats was compared to their own water consumption or to saccharin intake by saline-treated rats.
authors.affiliation: Department of Psychology, University of Kentucky, Lexington 40506-0044, USA. rabevi00@ukcc.uky.edu
authors.forename: R A
authors.initials: RA
authors.lastname: Bevins
authors.forename: T A
authors.initials: TA
authors.lastname: Delzer
authors.forename: M T
authors.initials: MT
authors.lastname: Bardo
mesh_terms: D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013649:Taste / Q000187:drug effects*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
chemical_list: D013764:Tetrahydronaphthalenes; C031349:7-hydroxy-2-N,N-dipropylaminotetralin