title: Chrysotile asbestos is the main cause of pleural mesothelioma.
abstract: In contrast to amphibole forms of asbestos, chrysotile asbestos is often claimed to be only a minor cause of malignant pleural mesothelioma, a highly fatal cancer of the lining of the thoracic cavity. In this article we examine the evidence from animal and human studies that relates to this issue. Reported data do not support widely quoted views regarding the relative inertness of chrysotile fibers in mesothelioma causation. In fact, examination of all pertinent studies makes it clear that chrysotile asbestos is similar in potency to amphibole asbestos. Since asbestos is the major cause of mesothelioma, and chrysotile constitutes 95% of all asbestos use world wide, it can be concluded that chrysotile asbestos is the main cause of pleural mesothelioma in humans.
authors.affiliation: School of Public Health, University of California, Berkeley 94720, USA.
authors.forename: A H
authors.initials: AH
authors.lastname: Smith
authors.forename: C C
authors.initials: CC
authors.lastname: Wright
mesh_terms: D000395:Air Pollutants, Occupational / Q000009:adverse effects* / Q000032:analysis; D000818:Animals; D017636:Asbestos, Amphibole / Q000008:administration & dosage / Q000009:adverse effects / Q000032:analysis; D017632:Asbestos, Serpentine / Q000008:administration & dosage / Q000009:adverse effects* / Q000032:analysis; D002170:Canada / Q000453:epidemiology; D015331:Cohort Studies; D004195:Disease Models, Animal; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000209:etiology*; D008654:Mesothelioma / Q000453:epidemiology / Q000209:etiology*; D015201:Meta-Analysis as Topic; D009784:Occupational Diseases / Q000453:epidemiology / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects; D012377:Rodentia; D014481:United States / Q000453:epidemiology
chemical_list: D000395:Air Pollutants, Occupational; D017636:Asbestos, Amphibole; D017632:Asbestos, Serpentine