title: Determination of the steady state tissue distribution of midazolam in the rat.
abstract: The aim of this study was to determine the steady state tissue:blood (Kb), tissue:plasma (Kp), and tissue:plasma water (Ku) partition coefficients of midazolam in all major organs and tissues in the rat, after development of a gas chromatographic assay. The Kp in 12 tissues ranged between 1.3 (in muscle) and 9.0 (in fat). Ku ranged correspondingly between 16 and 115.
authors.affiliation: Hospital Pharmacy, Malmö University Hospital, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Björkman
authors.forename: A
authors.initials: A
authors.lastname: Fyge
authors.forename: Z
authors.initials: Z
authors.lastname: Qi
mesh_terms: D000818:Animals; D001682:Biological Availability; D002849:Chromatography, Gas; D008874:Midazolam / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D014018:Tissue Distribution
chemical_list: D008874:Midazolam