Microalbuminuria as an early marker of severity in hypertensive pregnant women.
The value of microalbuminuria in predicting hypertensive complications in pregnant patients at high risk was tested in a prospective trial. A total of 276 patients were studied (142 in the study group vs 134 controls). Albumin was measured in 8-h overnight urine collection throughout pregnancy using radioimmunoassay technique. The pregnant women, in both the study and control groups demonstrated a statistically significant increase in albumin excretion rate in the second and third trimester compared with the first. Using logistic and linear regression models, the presence of microalbuminuria in the early third trimester was proven to be predictive of severe disease (odds ratio 2.1, confidence interval (CI) 1.26-3.53) and birth weight (R2 = 0.7, P < 0.05) in the study group. Intrauterine growth retardation and neonatal outcome were less predictable. With the introduction of radioimmunoassays, we believe severe disease can be predicted by detecting microalbuminuria in the early third trimester of pregnancy in high risk patients.
Bar
J
J
Department of Obstetrics and Gynecology, Beilinson Medical Center, Petah Tiqvu, Israel.
Friedman
S
S
Erman
A
A
Kaplan
B
B
Hod
M
M
Boner
G
G
Ovadia
J
J
D000328:Adult; D000419:Albuminuria / Q000652:urine; D015415:Biomarkers; D005260:Female; D005317:Fetal Growth Retardation; D005544:Forecasting; D006801:Humans; D006973:Hypertension / Q000503:physiopathology* / Q000652:urine*; D016017:Odds Ratio; D011247:Pregnancy; D011248:Pregnancy Complications; D011249:Pregnancy Complications, Cardiovascular; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third; D011863:Radioimmunoassay; D012044:Regression Analysis
D015415:Biomarkers