title: Rheumatoid arthritis complicated by pachy- and leptomeningeal rheumatoid nodule-like granulomas and systemic vasculitis.
abstract: Rheumatoid nodule is a frequent and characteristic extra-articular manifestation of rheumatoid arthritis (RA). Its involvement of central nervous system is a rare occurrence with only a few reported cases. A 78-year-old man with severe arthritis showing the formation of rheumatoid nodule-like granulomas in the dura and subarachnoid space along with the spleen is presented. The characteristic morphological finding of the granulomas was the presence of neutrophils and the absence of definite fibrinoid necrosis, which differed from the typical features of rheumatoid nodules previously described. The diagnosis should be based on the exclusion of diseases that may cause similar granulomatous reactions including infectious diseases. Additionally, there was systemic necrotizing vasculitis in the dura and multiple cerebral infarcts, although the association between vasculitis and cerebral infarcts was not clear.
authors.affiliation: Department of Pathology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kamio
authors.forename: S
authors.initials: S
authors.lastname: Kuramochi
authors.forename: R J
authors.initials: RJ
authors.lastname: Wang
authors.forename: S
authors.initials: S
authors.lastname: Hirose
authors.forename: Y
authors.initials: Y
authors.lastname: Hosoda
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000473:pathology*; D006099:Granuloma / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008297:Male; D008578:Meninges / Q000473:pathology*; D012218:Rheumatoid Nodule / Q000209:etiology / Q000473:pathology*; D014657:Vasculitis / Q000473:pathology*