title: Dehydroepiandrosterone sulfate and testosterone are independently associated with body fat distribution in premenopausal women.
abstract: To evaluate the relative importance of androgen and insulin concentrations in predicting body fat distribution, we measured their association with waist-hip ratio in a sample of 151 consecutively enrolled healthy premenopausal women age 18-24 years, after controlling for potential confounding variables. Dehydroepiandrosterone sulfate (DHEAS) and total testosterone were independently associated with waist-hip ratio, whereas insulin and free testosterone did not appear to play a role of comparable importance. Differences in concentrations of circulating DHEAS and total testosterone are independently associated with the waist-hip ratio in premenopausal women, providing epidemiologic support to the "neuroendocrine dysregulation" hypothesis for the pathogenesis of central obesity.
authors.affiliation: Division of Endocrinology, Beth Israel Hospital, Boston, MA 02215, USA.
authors.forename: C S
authors.initials: CS
authors.lastname: Mantzoros
authors.forename: E I
authors.initials: EI
authors.lastname: Georgiadis
authors.forename: K
authors.initials: K
authors.lastname: Evangelopoulou
authors.forename: N
authors.initials: N
authors.lastname: Katsilambros
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology*; D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D015992:Body Mass Index; D015986:Confounding Factors, Epidemiologic; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D017697:Premenopause / Q000097:blood / Q000502:physiology*; D012044:Regression Analysis; D013739:Testosterone / Q000097:blood*
chemical_list: D007328:Insulin; D013739:Testosterone; D019314:Dehydroepiandrosterone Sulfate