A new prenylated flavonol from the root of Petalostemon purpureus.
A new prenylated flavonol, petalopurpurenol (1), and a known dihydroflavonol, petalostemumol (2), have been isolated by DNA scission-guided fractionation of the organic portion of a 20% MeOH/CHCl3/H2O partition of a 50% MeOH/CHCl3 extract of the roots of Petalostemon purpureus. Compound 2 displayed moderate activity in DNA-scission assay. Both compounds 1 and 2 were evaluated for cytotoxicity in a panel of human cancer cell lines. The structures of petalopurpurenol (1) and petalostemumol (2) were determined by spectroscopic analysis.
Huang
L
L
Chemistry and Life Sciences Group, Research Triangle Institute, Research Triangle Park, North Carolina 27709, USA.
Fullas
F
F
McGivney
R J
RJ
Brown
D M
DM
Wani
M C
MC
Wall
M E
ME
Tucker
J C
JC
Beecher
C W
CW
Pezzuto
J M
JM
Kinghorn
A D
AD
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004249:DNA Damage; D018432:Drug Resistance, Multiple; D004354:Drug Screening Assays, Antitumor; D007887:Fabaceae / Q000737:chemistry*; D006801:Humans; D007624:KB Cells; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal
D000972:Antineoplastic Agents, Phytogenic