title: Two dose levels of ifosfamide in malignant mesothelioma.
abstract: Thirty-one consecutive patients with histologically proven and symptomatic malignant mesothelioma were treated with two dose levels of ifosfamide. The first group of 15 patients were given 2.3 g/m2/day for 5 days (group A) and the following 16 patients were treated with 1.2 g/m2/day for 5 days of ifosfamide (group B). Treatment cycles were repeated every 3 weeks. While the partial response rate (PR) in group A was 38.5%, it was only 6.25% in group B (P > 0.05). The 95% confidence interval for the difference in PR rates was 3.3-61.2% > The overall survival (OAS) of groups A and B were similar (8 months and 9 months, respectively). Higher Grade 3-4 myelotoxicity was observed in group A when compared to group B (30.8% vs. 18.7%; P > 0.05). In conclusion, a favourable response rate could be achieved in malignant mesothelioma with high dose ifosfamide at the cost of increased toxicity.
authors.affiliation: Ankara University Medical School, Ibn-i Sing Hospital, Medical Oncology Department, Ankara, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Içli
authors.forename: H
authors.initials: H
authors.lastname: Karaoğuz
authors.forename: S
authors.initials: S
authors.lastname: Hastürk
authors.forename: B
authors.initials: B
authors.lastname: Kurt
authors.forename: H
authors.initials: H
authors.lastname: Akbulut
authors.forename: D
authors.initials: D
authors.lastname: Dinçol
authors.forename: A
authors.initials: A
authors.lastname: Demirkazik
authors.forename: F
authors.initials: F
authors.lastname: Cay
authors.forename: S
authors.initials: S
authors.lastname: Akyar
mesh_terms: D000328:Adult; D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008654:Mesothelioma / Q000188:drug therapy*; D008875:Middle Aged
chemical_list: D018906:Antineoplastic Agents, Alkylating; D007069:Ifosfamide