title: Biologic responses of the pulp to single-tooth dento-osseous osteotomy.
abstract: OBJECTIVE
  This study was conducted to investigate biologic responses of the pulp to single-tooth dento-osseous osteotomy and to explore an appropriate level of transverse bone resection for maintaining biologic activity of the pulp in monkeys.
  
  
  METHODS
  The levels of transverse bone resection were designed at approximately 10 mm (10 mm group) and 5 mm (5 mm group) above the apices. Histologic and histomorphometric changes were evaluated microscopically, and changes in blood flow in the pulp were also measured in terms of vascular responses to a vasoconstrictor (noradrenaline, NA).
  
  
  RESULTS
  Vacuolar degeneration in the pulp chamber associated with less number of the pulp cells were more prominent in the 5 mm group, and the response of blood flow to NA was maintained better in the 10-mm group.
  
  
  CONCLUSIONS
  It is shown in this 8-week experiment that biologic activity of the pulp is much better preserved in the 10-mm group than in the 5-mm group, whereas the pulpal response may become similar if observed for a longer period.
authors.affiliation: Hiroshima University Dental Hospital, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
authors.forename: K
authors.initials: K
authors.lastname: Oshima
authors.forename: K
authors.initials: K
authors.lastname: Tanne
mesh_terms: D000539:Alveolar Process / Q000601:surgery*; D000818:Animals; D002452:Cell Count; D003782:Dental Pulp / Q000098:blood supply / Q000294:innervation / Q000473:pathology; D003790:Dental Pulp Necrosis / Q000209:etiology*; D007150:Immunohistochemistry; D007180:Incisor; D017078:Laser-Doppler Flowmetry; D008251:Macaca; D008437:Maxilla; D010027:Osteotomy / Q000009:adverse effects* / Q000379:methods; D019227:Tooth Apex; D014087:Tooth Movement Techniques / Q000379:methods*