Evolutionary perspective on a composite Shigella flexneri 2a virulence plasmid-borne locus comprising three distinct genetic elements.
Nucleotide sequence analysis of a Shigella flexneri 2a virulence plasmid-borne locus revealed that it comprised three distinct genetic elements: a stretch of colicin 1a/1b-linked sequence, a truncated IS911 element, and a third element containing two ORFs that shared a high level of similarity to a Salmonella-specific chromosomal sequence. Examination of other known IS911-like sequences showed that these sequences also were frequently associated with other accessory elements and appeared to be prone to partial deletion events. Analysis of the data led to a model of the evolution of this unusual composite locus.
Rajakumar
K
K
Department of Microbiology, Monash University, Melbourne, Vic, Australia. Kumar.Rajakumar@med.monash.edu.au
Luo
F
F
Sasakawa
C
C
Adler
B
B
D000595:Amino Acid Sequence; D001483:Base Sequence; D003087:Colicins / Q000235:genetics; D004251:DNA Transposable Elements; D019143:Evolution, Molecular; D008957:Models, Genetic; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D009154:Mutation; D016366:Open Reading Frames; D010957:Plasmids / Q000235:genetics*; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D012763:Shigella flexneri / Q000235:genetics* / Q000472:pathogenicity*
D003087:Colicins; D004251:DNA Transposable Elements