Age and racial distribution of prostatic intraepithelial neoplasia.
OBJECTIVE
To study the prevalence, extent and evolution of high-grade prostatic intraepithelial neoplasia (HGPIN) in African-American and Caucasian men of a wide age range in order to help clarify the role this lesion may play in the racial differences of prostate cancer.


METHODS
The lesion was documented in step-sectioned, entirely submitted prostates of two study populations: 525 autopsied men who died of trauma and 1,000 patients who had retropubic radical prostatectomy for clinically localized carcinoma of the prostate.


RESULTS
We found that HGPIN starts in young individuals and increases progressively with advancing age in both races but is more prevalent in African-Americans. Additionally, the more extensive form of HGPIN with multifocal or diffuse involvement of the gland appears at a younger age in African-Americans.


CONCLUSIONS
Microscopic foci of HGPIN can be documented in males in the 3rd and 4th decades with the lesion becoming more extensive in older men. The finding that HGPIN is both more prevalent and its more diffuse form appears earlier in African-Americans, indicates a potentially important role for this lesion in the race-related discrepancies associated with this disease.
Sakr
W A
WA
Department of Pathology, Harper Hospital, Detroit, MI 48201, USA.
Grignon
D J
DJ
Haas
G P
GP
Heilbrun
L K
LK
Pontes
J E
JE
Crissman
J D
JD
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D044383:Black People; D015331:Cohort Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology* / Q000648:ultrastructure; D011468:Prostatectomy; D019048:Prostatic Intraepithelial Neoplasia / Q000453:epidemiology*; D011471:Prostatic Neoplasms / Q000453:epidemiology*; D044465:White People; D001741:Black or African American