A research to develop a predicting system of mammalian subacute toxicity. II. Single dose detailed toxicity studies.
"Single dose detailed toxicity study" in rats was conducted with 6 chemical substances to establish a predicting system of subacute toxicity of non-congeneric industrial chemicals. In the detailed examinations, new and previously reported biological parameters were developed and utilized for the establishment and confirmation of the correlations for both qualitative and quantitative prediction of target organs and effects in repeated dose toxicity studies of non-congeners; the new parameters were concerned with liver, kidneys and blood and the established relating equations for prediction had a correlation coefficient of 0.83 (liver), 0.49 (kidneys) and 0.94 (blood), while the old parameters effectively confirmed the previous correlations. The serial changes in the study gave a biological explanation to the established relationships between acute and subacute toxicities in terms of extrapolation.
Yamaguchi
T
T
Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., Osaka, Japan.
Watanabe
T
T
Sako
H
H
Isobe
N
N
Nishimura
H
H
Saito
S
S
Shono
F
F
Adachi
H
H
Yabuki
M
M
Shiba
K
K
Matsuo
M
M
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D015386:Hazardous Substances / Q000097:blood / Q000633:toxicity*; D007221:Industry; D007674:Kidney Diseases / Q000139:chemically induced; D008297:Male; D011237:Predictive Value of Tests; D051381:Rats; D014116:Toxicology / Q000379:methods
D015386:Hazardous Substances