A new saxitoxin analogue from a xanthid crab Atergatis floridus.
A novel paralytic toxin was isolated from toxic specimens of a xanthid crab Atergatis floridus inhabiting the Pacific coast of Shikoku Island. Its structure was deduced to be 11-saxitoxinethanoic acid (SEA) based on high-performance liquid chromatography, electrospray ionization mass spectrometry, and 1H and 13C-NMR spectrometries. This acid was assumed to exist as an equilibrium mixture of three tautomers, the main tautomer being the hydrate form 11 beta-epimer. SEA showed a specific toxicity of 830 mouse units per mumole on i.p. injection into mice.
Arakawa
O
O
Faculty of Fisheries, Kagoshima University, Japan.
Nishio
S
S
Noguchi
T
T
Shida
Y
Y
Onque
Y
Y
D019342:Acetic Acid / Q000378:metabolism; D000818:Animals; D003386:Brachyura; D002851:Chromatography, High Pressure Liquid; D005397:Fish Venoms / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D012015:Reference Standards; D012530:Saxitoxin / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism
D005397:Fish Venoms; D012530:Saxitoxin; D019342:Acetic Acid