Beta-endorphin concentration in peripheral blood mononuclear cells of elderly depressed patients--effects of phosphatidylserine therapy.
beta-Endorphin (beta-EP) concentrations were measured in peripheral blood mononuclear cells of 10 elderly women with major depressive disorders, 10 age- and sex-matched healthy controls and 10 young healthy controls. beta-EP values were measured in resting condition and after stimulation with corticotropin-releasing hormone (CRH). In patients, beta-EP values were measured in drug-free condition and after 30 days of treatment with phosphatidylserine (BCPS), 200 mg/day, p.o. Basal and CRH-stimulated beta-EP concentrations were the same in patients and controls; in patients they did not change after BCPS, in spite of significant improvement of the depressive symptomatology.
Brambilla
F
F
Ospedale Psichiatrico Pini, Milano, Italy.
Maggioni
M
M
Panerai
A E
AE
Sacerdote
P
P
Cenacchi
T
T
D000368:Aged; D000375:Aging / Q000378:metabolism*; D003866:Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D009000:Monocytes / Q000378:metabolism*; D010718:Phosphatidylserines / Q000627:therapeutic use*; D001615:beta-Endorphin / Q000378:metabolism*
D010718:Phosphatidylserines; D001615:beta-Endorphin