Growth inhibition of a human oral bacterium Porphyromonas gingivalis by rat cysteine proteinase inhibitor cystatin S.
Agar diffusion analysis demonstrated that rat cystatin S, a cysteine proteinase inhibitor, inhibited the growth of all tested strains of a human oral, Gram-negative anaerobic periodontopathogen Porphyromonas gingivalis. Its specific inhibitory activity against this tissue-invasive bacterium but not against other tested oral bacterial species emphasized the importance of specific cysteine proteinases for growth of P. gingivalis.
Umemoto
T
T
Department of Oral Microbiology, School of Dentistry, Asahi University, Gifu-ken, Japan.
Naito
Y
Y
Li
M
M
Suzuki
I
I
Namikawa
I
I
D000818:Animals; D015891:Cystatins / Q000494:pharmacology*; D016967:Fusobacterium nucleatum / Q000187:drug effects; D006131:Growth Inhibitors / Q000494:pharmacology; D016966:Porphyromonas gingivalis / Q000187:drug effects* / Q000254:growth & development; D018713:Prevotella intermedia / Q000187:drug effects; D051381:Rats; D055333:Salivary Cystatins
C525173:CST4 protein, human; C525174:Cyss protein, rat; D015891:Cystatins; D006131:Growth Inhibitors; D055333:Salivary Cystatins