A review on treatment of bleeding peptic ulcer: a collaborative task of gastroenterologist and surgeon.
The majority of patients presenting with acute upper gastrointestinal haemorrhage bleed from peptic diseases erosive gastritis and duodenal or gastric ulcers. Early gastroscopy is essential in order to reach a diagnosis, assess the prognosis, and institute appropriate therapy. In a meta-analysis it was shown that H2-antagonists significantly reduced mortality. However, two large, prospective and placebo-controlled studies with famotidine and omeprazole failed to show reduction of rebleeding or death. The value of endoscopic haemostatic therapy in patients with high-risk peptic ulcers (active bleeding and non-bleeding visible vessel) has been firmly established with 75% decrease in rebleeding and operation rate, and a 40% reduction in mortality. Risk factors for an adverse outcome are: elderly patients, concomitant diseases and large ulcers in the posterior duodenal bulb or on the lesser curvature. The mortality for emergency surgery in upper GI bleeding is still 10-50%. The mortality of elective operations is less than 2%. Some studies have reduced mortality by avoiding emergency surgery through early elective surgery in high-risk patients.
Kolkman
J J
JJ
Dept. of Gastroenterology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.
Meuwissen
S G
SG
D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004724:Endoscopy; D006801:Humans; D009426:Netherlands; D010438:Peptic Ulcer Hemorrhage / Q000601:surgery / Q000628:therapy*; D011379:Prognosis
D000897:Anti-Ulcer Agents