title: Lowering the threshold for the diagnosis of gestational diabetes.
abstract: OBJECTIVE
  Our purpose was to determine whether lowering the diagnostic threshold for gestational diabetes mellitus on 3-hour 100 gm oral glucose tolerance testing will select a population at risk for adverse perinatal outcome.
  
  
  METHODS
  In this retrospective study 434 patients with an abnormal 50 gm glucose screen result (> or = 140 mg/dl) underwent a standardized 3-hour oral glucose tolerance test. The results were stratified according to maternal weight and the criteria recommended by Sacks or Carpenter. Birth weight and rate of macrosomia were the primary perinatal outcome variables analyzed.
  
  
  RESULTS
  Analysis of the data set stratified according to the Sacks criteria revealed results very similar to the Carpenter criteria data set. Patients who would have been newly diagnosed with gestational diabetes mellitus only if the lowered criteria were used (group 2) were older and heavier. No other variable comparisons achieved statistical significance. When the same patients were stratified according to prepregnancy weight, overweight patients were older, gained less weight during the third trimester, underwent cesarean section more often, and had higher cumulative maternal morbidity. Regression analysis showed that the degree of hyperglycemia did not predict macrosomia or influence birth weight, but prepregnant maternal body mass index was associated with macrosomia.
  
  
  CONCLUSIONS
  Fetal macrosomia is influenced by maternal prepregnant body mass index. Lowering the glucose tolerance test threshold would result in overdiagnosis of gestational diabetes mellitus without improving perinatal outcome.
authors.affiliation: Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson 39216-4505, USA.
authors.forename: O A
authors.initials: OA
authors.lastname: Rust
authors.forename: J A
authors.initials: JA
authors.lastname: Bofill
authors.forename: M E
authors.initials: ME
authors.lastname: Andrew
authors.forename: T A
authors.initials: TA
authors.lastname: Kincaid
authors.forename: T M
authors.initials: TM
authors.lastname: Stubbs
authors.forename: E H
authors.initials: EH
authors.lastname: Miller
authors.forename: J C
authors.initials: JC
authors.lastname: Morrison
mesh_terms: D001724:Birth Weight; D015992:Body Mass Index; D016640:Diabetes, Gestational / Q000175:diagnosis*; D004056:Differential Threshold; D005260:Female; D005320:Fetal Macrosomia / Q000453:epidemiology; D005951:Glucose Tolerance Test; D006801:Humans; D015994:Incidence; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies