Androgenic regulation of protein kinase CK1 in the prostatic cell.
We examined the androgenic regulation of protein kinase CK1 in rat ventral prostate cytosolic and chromatin fractions. On androgen deprivation, CK1 in both the nuclear and cytoplasmic compartments decreases slowly at a similar rate. Stimulation of regrowth in the prostate does not evoke an early differential modulation in the CK1 because it increased in both the cytosol and chromatin only by 24 h after androgenic stimulus. These changes in CK1 relate to its proposed role in cell regulation at mitosis and differ from those in protein kinase CK2 that demonstrates rapid modulations in the nuclear compartment under similar conditions.
Ahmed
K
K
Department of Laboratory Medicine and Pathology, Department of Veterans Affairs Medical Center and University of Minnesota 55417, USA.
Davis
A T
AT
Canbulat
E C
EC
Marin
O
O
Pinna
L A
LA
D000595:Amino Acid Sequence; D000728:Androgens / Q000502:physiology*; D000818:Animals; D047388:Casein Kinases; D002467:Cell Nucleus / Q000201:enzymology; D002843:Chromatin / Q000201:enzymology; D003600:Cytosol / Q000201:enzymology; D013196:Dihydrotestosterone / Q000494:pharmacology; D008297:Male; D008969:Molecular Sequence Data; D009919:Orchiectomy; D010455:Peptides / Q000138:chemical synthesis / Q000378:metabolism; D011467:Prostate / Q000187:drug effects / Q000201:enzymology*; D011494:Protein Kinases / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000728:Androgens; D002843:Chromatin; D010455:Peptides; D013196:Dihydrotestosterone; D011494:Protein Kinases; D047388:Casein Kinases