title: Endothelin-1 and interleukin-8 in high altitude pulmonary oedema.
abstract: We present a case of high altitude pulmonary oedema (HAPE) with pulmonary hypertension and polymorphonuclear leucocyte (PMN) accumulation in bronchoalveolar lavage fluid (BALF), which occurred in a 21 year old man. Plasma endothelin-1 (ET-1) and interleukin-8 (IL-8) concentration in BALF were elevated on admission, and returned to normal level at recovery, when the pulmonary artery pressure and the PMN counts in BALF were normal. In addition, E-selectin and intercellular adhesion molecule-1 (ICAM-1) in BALF were also slightly increased on admission. These findings suggest that endothelin-1 is a vasoconstrictor which contributes to the pulmonary hypertension in high altitude pulmonary oedema, and that some of the inflammatory mediators play an important role in chemotaxis and accumulation of polymorphonuclear leucocytes in the development of high altitude pulmonary oedema.
authors.affiliation: First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Droma
authors.forename: T
authors.initials: T
authors.lastname: Hayano
authors.forename: Y
authors.initials: Y
authors.lastname: Takabayashi
authors.forename: T
authors.initials: T
authors.lastname: Koizumi
authors.forename: K
authors.initials: K
authors.lastname: Kubo
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: M
authors.initials: M
authors.lastname: Sekiguchi
mesh_terms: D000328:Adult; D000532:Altitude Sickness / Q000150:complications*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D002634:Chemotaxis, Leukocyte; D019040:E-Selectin / Q000032:analysis; D019332:Endothelin-1 / Q000097:blood*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis; D016209:Interleukin-8 / Q000032:analysis*; D007958:Leukocyte Count; D008297:Male; D009051:Mountaineering / Q000293:injuries; D009504:Neutrophils / Q000473:pathology; D011654:Pulmonary Edema / Q000097:blood / Q000209:etiology / Q000378:metabolism*; D011669:Pulmonary Wedge Pressure; D014662:Vasoconstrictor Agents / Q000097:blood
chemical_list: D019040:E-Selectin; D019332:Endothelin-1; D016209:Interleukin-8; D014662:Vasoconstrictor Agents; D018799:Intercellular Adhesion Molecule-1