title: Synthesis and pharmacological profile of novel N-substituted N-[5H-[1]benzopyrano[4,3-d]pyrimidin-2-YL]-N-methylglycinamides.
abstract: The title compounds were synthesized by cyclizing 3-dimethylaminomethylene-4-chromanone with creatine to give the acid 2 that was successively converted into the corresponding amides 3a-f via diphenylphosphorylazide and the relevant amines. The free acid 2 and some of 3a-f showed antiinflammatory, hypotensive and antiarrhythmic properties.
authors.affiliation: Instituto di Scienze Farmaceutiche dell'Universita, Genova, Italy.
authors.forename: O
authors.initials: O
authors.lastname: Bruno
authors.forename: S
authors.initials: S
authors.lastname: Schenone
authors.forename: A
authors.initials: A
authors.lastname: Ranise
authors.forename: F
authors.initials: F
authors.lastname: Bondavalli
authors.forename: M
authors.initials: M
authors.lastname: D'Amico
authors.forename: W
authors.initials: W
authors.lastname: Filippelli
authors.forename: L
authors.initials: L
authors.lastname: Berrino
authors.forename: F
authors.initials: F
authors.lastname: Rossi
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D005998:Glycine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D051379:Mice; D051381:Rats
chemical_list: D000889:Anti-Arrhythmia Agents; D000893:Anti-Inflammatory Agents; D000959:Antihypertensive Agents; C018556:glycine amide; D005998:Glycine