Agmatine enhances caloric intake and dietary carbohydrate preference in satiated rats.
Agmatine is a decarboxylated metabolite of arginine endogenous to the brain. In vitro, agmatine inhibits binding of clonidine to alpha 2-adrenergic and imidazoline receptors. We have shown that acute administration of agmatine increases caloric intake and dietary carbohydrate preference in satiated rats. In contrast, agmatine does not modulate caloric intake in hungry rats. Furthermore, repeated administration of high doses of agmatine does not decrease its ability to stimulate appetite.
Prasad
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Department of Medicine, Louisiana State University Medical Center, New Orleans 70112, USA.
Prasad
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D000376:Agmatine / Q000494:pharmacology*; D000818:Animals; D001066:Appetite / Q000187:drug effects*; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D002149:Energy Intake / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D004040:Dietary Carbohydrates; D000376:Agmatine