title: Evaluation of the frequency of HLA determinants in patients with gingival overgrowth induced by cyclosporine-A.
abstract: This study has been designed to investigate the immunogenetic susceptibility of Cyclosporine-A (CsA) immunosuppressed renal transplant patients to development of gingival overgrowth, and the amplifying effect of calcium channel blockers on the severity of this clinical entity. 52 renal transplant recipients were selected and initially grouped as follows: group (Gp)1: CsA (n = 7); Gp 2: CsA + verapamil (n = 26); Gp 3: CsA + diltiazem (n = 6); Gp 4: CsA + nifedipine (n = 13). These groups were not found to be significantly different in age, sex, plaque index (PlI), gingival index (GI), calculus index, periodontal probing depth, serum CsA level, or duration of CsA therapy (p > 0.05). No significant (p > 0.05) additive effect of the calcium channel blockers on the gingival overgrowth (GO) was assessed. The main group (n = 52) was evaluated for the correlations between the clinical and the pharmacological variables and the GO. GI (rs = 0.60) and the periodontal probing depth (rs = 0.71) were found to be moderately correlated with the GO. The patients were regrouped based on the severity of overgrowth and recognized as responders (n = 26) and nonresponders (n = 26). Age, sex, calculus index, serum CsA level, duration of the CsA therapy, were not statistically different among these groups (p > 0.05). PlI, GI, periodontal probing depth, and GO were significantly higher in the responder group (p > 0.05). Analysis of HLA distribution of the responders and the nonresponders and comparison with the controls (n = 3731) revealed that a statistically significant (p < 0.001)% of the nonresponders were positive for HLA-DR1. These data would indicate that an immunogenetic predisposition should be suspected in the pathogenesis of the entity, and that HLA-DR1 would have a protective rôle against gingival overgrowth induced by CsA.
authors.affiliation: Department of Periodontology, Faculty of Dentistry, University of Istanbul.
authors.forename: I
authors.initials: I
authors.lastname: Cebeci
authors.forename: A
authors.initials: A
authors.lastname: Kantarci
authors.forename: E
authors.initials: E
authors.lastname: Firatli
authors.forename: S
authors.initials: S
authors.lastname: Aygün
authors.forename: H
authors.initials: H
authors.lastname: Tanyeri
authors.forename: A E
authors.initials: AE
authors.lastname: Aydin
authors.forename: M
authors.initials: M
authors.lastname: Carin
authors.forename: U
authors.initials: U
authors.lastname: Güç
authors.forename: O
authors.initials: O
authors.lastname: Tuncer
mesh_terms: D000328:Adult; D000940:Antigenic Variation; D002121:Calcium Channel Blockers / Q000009:adverse effects; D016009:Chi-Square Distribution; D016572:Cyclosporine / Q000009:adverse effects*; D004110:Diltiazem / Q000009:adverse effects; D004198:Disease Susceptibility; D004338:Drug Combinations; D005260:Female; D019214:Gingival Overgrowth / Q000139:chemically induced / Q000276:immunology*; D006680:HLA Antigens / Q000235:genetics / Q000502:physiology*; D015798:HLA-DR1 Antigen / Q000502:physiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D009543:Nifedipine / Q000009:adverse effects; D010597:Pharmacogenetics; D018709:Statistics, Nonparametric; D014700:Verapamil / Q000009:adverse effects
chemical_list: D002121:Calcium Channel Blockers; D004338:Drug Combinations; D006680:HLA Antigens; D015798:HLA-DR1 Antigen; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D014700:Verapamil; D004110:Diltiazem; D009543:Nifedipine