beta-Adrenoceptor agonists-induced desensitization in rat trachea.
The development and the characteristics of beta-adrenoceptor agonists-induced desensitization in rat trachea were studied. Tracheal strips were contracted with carbachol and cumulative concentration-response curves for various beta-adrenoceptor agonists were constructed before and after 30-min incubation either with the same beta-adrenoceptor agonist or with another beta-adrenoceptor agonist. Some problems of the in vitro desensitization in rat trachea were also considered.
Vassilev
P P
PP
Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D015232:Dinoprostone / Q000494:pharmacology; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013806:Theophylline / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects*
D000318:Adrenergic beta-Agonists; D010726:Phosphodiesterase Inhibitors; D002217:Carbachol; D013806:Theophylline; D015232:Dinoprostone; D007545:Isoproterenol; D000420:Albuterol; D009638:Norepinephrine