title: Effects of endoscopic variceal sclerotherapy on azygos vein blood flow and systemic haemodynamics.
abstract: The present study was designed to determine the systemic haemodynamic effects of obliterating oesophageal varices by endoscopic sclerotherapy. We evaluated systemic and splanchnic haemodynamics before and after the first course of sclerotherapy in cirrhotic patients. The baseline cardiac index was significantly correlated with baseline azygos vein blood flow (r = 0.64; P < 0.01) and the azygos vein blood flow and cardiac index significantly decreased (-33% and -16%, respectively; P < 0.01) following sclerotherapy. The systemic vascular resistance index was also increased significantly (+ 20%; P < 0.01) in these patients. Moreover, the per cent change in azygos vein blood flow was directly correlated with that of the cardiac index (r = 0.51; P < 0.03). We conclude from these findings that the obliteration of portosystemic collaterals by sclerotherapy significantly reverses hyperdynamic circulation in such patients via a decrease in cardiac preload. The blood flow of the portosystemic shunt per se is a leading contributor to the hyperdynamic circulation observed in patients with well-developed portal systemic collateral vessels.
authors.affiliation: First Department of Internal Medicine, School of Medicine, Fukuoka University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yokoyama
authors.forename: H
authors.initials: H
authors.lastname: Shijo
authors.forename: K
authors.initials: K
authors.lastname: Ota
authors.forename: K
authors.initials: K
authors.lastname: Kubara
authors.forename: H
authors.initials: H
authors.lastname: Kokawa
authors.forename: T
authors.initials: T
authors.lastname: Kim
authors.forename: N
authors.initials: N
authors.lastname: Akiyoshi
authors.forename: H
authors.initials: H
authors.lastname: Tokumitsu
authors.forename: M
authors.initials: M
authors.lastname: Okumura
mesh_terms: D000328:Adult; D000368:Aged; D001401:Azygos Vein / Q000503:physiopathology*; D001647:Bile Acids and Salts / Q000097:blood; D001810:Blood Volume; D004724:Endoscopy; D004932:Esophageal and Gastric Varices / Q000628:therapy*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008099:Liver / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow; D015911:Sclerotherapy; D013152:Splanchnic Circulation
chemical_list: D001647:Bile Acids and Salts