title: The German Glomerulonephritis Therapy Study: 10 years of controlled randomized trials for the treatment of idiopathic glomerulonephritis.
abstract: The German Collaborative Glomerulonephritis Therapy Study, which celebrated its 10th anniversary in 1996, has collected data on more than 1,000 patients with biopsy-proven glomerulonephritis. 929 patients could be evaluated and 500 were treated according to at least one of various protocols developed for a randomized controlled trial. Current results show that prednisolone is effective in minimal-change nephropathy, and in combination with other immunosuppressants it can reduce proteinuria in individual cases of focal and segmental glomerulosclerosis, membranous glomerulonephritis and nephrotic IgA nephropathy. The majority of tested treatment protocols did not prove to be superior to symptomatic therapy for long-term outcome.
authors.affiliation: Medizinische Universitätsklinik und Poliklinik, Abteilung III, Sektion Nierenund Hochdruckkrankheiten, Tübingen, Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Risler
authors.forename: N
authors.initials: N
authors.lastname: Braun
authors.forename: D
authors.initials: D
authors.lastname: Bach
authors.forename: R
authors.initials: R
authors.lastname: Fünfstück
authors.forename: B
authors.initials: B
authors.lastname: Grabensee
authors.forename: C
authors.initials: C
authors.lastname: Grupp
authors.forename: C
authors.initials: C
authors.lastname: Haufe
authors.forename: P
authors.initials: P
authors.lastname: Heering
authors.forename: F
authors.initials: F
authors.lastname: Keller
authors.forename: B
authors.initials: B
authors.lastname: Krämer
authors.forename: G A
authors.initials: GA
authors.lastname: Müller
authors.forename: P
authors.initials: P
authors.lastname: Schollmeyer
authors.forename: G
authors.initials: G
authors.lastname: Stein
authors.forename: I
authors.initials: I
authors.lastname: Zäuner
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D003404:Creatinine / Q000097:blood; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005858:Germany; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D011507:Proteinuria / Q000188:drug therapy / Q000652:urine; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D003404:Creatinine; D008775:Methylprednisolone