Cyclophosphamide in the treatment of toxic epidermal necrolysis.
A patient with non-small cell lung carcinoma and recent radiotherapy for brain metastases developed toxic epidermal necrolysis (TEN) shortly after therapy with phenytoin was initiated for a seizure. Exfoliation progressed to involve 90% of her body surface despite treatment with high-dose corticosteroids for 5 days, but sloughing and systemic toxicity ceased within 2 days of initiating therapy with intravenous cyclophosphamide (300 mg/day). Reepithelialization rapidly followed. This experience and the reports of others suggest that intravenous cyclophosphamide is helpful in the treatment of TEN.
Frangogiannis
N G
NG
Department of Internal Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Boridy
I
I
Mazhar
M
M
Mathews
R
R
Gangopadhyay
S
S
Cate
T
T
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects; D001830:Body Surface Area; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000556:secondary; D002289:Carcinoma, Non-Small-Cell Lung / Q000532:radiotherapy / Q000556:secondary; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D007275:Injections, Intravenous; D008175:Lung Neoplasms / Q000473:pathology; D010672:Phenytoin / Q000009:adverse effects; D012867:Skin / Q000503:physiopathology; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D014945:Wound Healing
D000927:Anticonvulsants; D007166:Immunosuppressive Agents; D010672:Phenytoin; D003520:Cyclophosphamide