title: [Indications and role of albumin for vascular loading in trauma patients and during preoperative period].
abstract: The use of albumin solutions for volume replacement remains controversial. The last American guidelines recommend the use of albumin for resuscitation in case of a contra-indication of artificial colloids or the requirement of sodium restriction. Recent trials did not show any beneficial effect of albumin on the mortality and morbidity rates. Only an improvement of the rheologic conditions has been found with albumin (and dextran 40), in comparison with starch and gelatin. On the basis of cost-effectiveness considerations, artificial colloids should be at this time favoured over albumin for intravascular expansion, except in pregnant women. For resuscitation, albumin could be used when the recommended upper limit of hydroxyethyl starch vol-ume has been reached and fresh frozen plasma not yet required. During preoperative haemodilution, low molecular weight hydroxyethyl starch has at least the same efficacy as albumin. When a rheological effect is required, albumin could be used.
authors.affiliation: Département des urgences et DAR I, hôpital Pellegrin, Bordeaux, France.
authors.forename: F
authors.initials: F
authors.lastname: Sztark
mesh_terms: D000418:Albumins / Q000494:pharmacology / Q000627:therapeutic use*; D001810:Blood Volume; D006438:Hemodilution / Q000379:methods; D006801:Humans; D010952:Plasma Substitutes / Q000008:administration & dosage; D010953:Plasma Volume / Q000187:drug effects; D011300:Preoperative Care / Q000379:methods*; D012769:Shock / Q000628:therapy*; D014947:Wounds and Injuries / Q000628:therapy*
chemical_list: D000418:Albumins; D010952:Plasma Substitutes