title: Effect of ciprofloxacin on ciliary motility of rabbit airway epithelium.
abstract: To determine the effect of the new quinolone ciprofloxacin on airway ciliary motility, we studied ciliary beat frequency (CBF) of rabbit tracheal epithelium using an in-vitro microphoto-oscillation method. Incubation of the cells with ciprofloxacin increased CBF in a concentration-dependent manner, the maximal increase from the baseline value and the EC50 being 17.1 +/- 2.0% (P < 0.01) and 10(-7.25) M, respectively. This ciliary stimulatory effect was not affected by propranolol or indomethacin but was nullified by verapamil. These results suggest that ciprofloxacin probably increases airway epithelial ciliary motility by facilitating Ca2+ influx through a voltage-dependent channel.
authors.affiliation: First Department of Medicine, Tokyo Women's Medical College, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Takemura
authors.forename: J
authors.initials: J
authors.lastname: Tamaoki
authors.forename: A
authors.initials: A
authors.lastname: Chiyotani
authors.forename: K
authors.initials: K
authors.lastname: Konno
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002923:Cilia / Q000187:drug effects*; D002939:Ciprofloxacin / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D009068:Movement / Q000187:drug effects*; D010784:Photomicrography / Q000379:methods*; D011817:Rabbits; D014132:Trachea / Q000187:drug effects* / Q000648:ultrastructure
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin