title: Comparable amyloid beta-protein (A beta) 42(43) and A beta 40 deposition in the aged monkey brain.
abstract: Two distinct species of amyloid beta-protein (A beta), A beta 42(43) and A beta 40, are deposited in the brains of patients with Alzheimer's disease and normal aged individuals. A beta 42(43), the long tailed A beta, is the initially and predominantly deposited species in senile plaques. Deposition of A beta is also observed in the aged monkey brains. We investigated the A beta species in the aged monkey brains immunocytochemically using monoclonal antibodies that discriminate between the C-termini of A beta 42(43) and A beta 40. We report here that A beta 40 as well as A beta 42(43) deposit in various types of senile plaques, including diffuse plaques of the aged monkey brain and that the ratio of A beta 40 to A beta 42(43) is higher compared with that in human brain.
authors.affiliation: Department of Neurology, Tokyo Metropolitan Geriatric Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kanemaru
authors.forename: T
authors.initials: T
authors.lastname: Iwatsubo
authors.forename: Y
authors.initials: Y
authors.lastname: Ihara
mesh_terms: D000375:Aging / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D000911:Antibodies, Monoclonal; D001923:Brain Chemistry / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D008251:Macaca; D009410:Nerve Degeneration / Q000502:physiology
chemical_list: D016229:Amyloid beta-Peptides; D000911:Antibodies, Monoclonal