Gene transfer and therapeutic drug monitoring.
During the next decade, gene therapy will evolve from a medical curiosity into an essential component of medical practice. One of the elements necessary for this transition will be the development of simple and accurate ways of monitoring both the vectors used to transfer the genes of interest and the function of the genes themselves. This article reviews the difficulties in achieving these aims and describes ways in which the technology of gene transfer offers a novel means of monitoring current therapies.
Brenner
M K
MK
Cell and Gene Therapy Program, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
D016903:Drug Monitoring / Q000379:methods*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors / Q000145:classification; D006412:Hematopoietic Stem Cells; D006801:Humans