Localization of monoamine oxidases in human peripheral tissues.
Localization of monoamine oxidases (MAO) A and B and beta-adrenoceptors, was studied in aged human peripheral tissues (age 68-80 years) by quantitative autoradiography. The tissues analyzed were heart, lung, liver, kidney, spleen and duodenum. [3H]Ro41-1049 and [3H]lazabemide, two recently characterized selective radioligands were used to map MAO-A and MAO-B respectively. The regional pattern of distribution of MAO-A and MAO-B did not differ markedly, except in kidney and especially in duodenum. Highest levels of MAOs were measured in liver, and lowest in spleen. MAO-A was more abundant than MAO-B in lung and duodenal mucosa, and the reverse was true in myocardium. These results show marked differences in the abundance and patterns of distribution of MAOs, particularly MAO-B, in human and rodent peripheral tissues.
Saura
J
J
Biochemistry Unit, School of Medicine, University of Barcelona, Spain.
Nadal
E
E
van den Berg
B
B
Vila
M
M
Bombi
J A
JA
Mahy
N
N
D000368:Aged; D000369:Aged, 80 and over; D001345:Autoradiography; D004386:Duodenum / Q000201:enzymology; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008168:Lung / Q000201:enzymology; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology; D010848:Picolinic Acids / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D013154:Spleen / Q000201:enzymology; D013844:Thiazoles / Q000378:metabolism
D007527:Isoenzymes; D008996:Monoamine Oxidase Inhibitors; D010848:Picolinic Acids; D011943:Receptors, Adrenergic, beta; D013844:Thiazoles; C063456:Ro 41-1049; C059303:lazabemide; D008995:Monoamine Oxidase