title: Pharmacokinetic studies of the fragrance compound 1,8-cineol in humans during inhalation.
abstract: The present study was undertaken to investigate the pharmacokinetics of 1,8-cineol in human subjects during prolonged inhalation. The results showed that 1,8-cineol is well absorbed from breathing air, with a peak plasma concentration after approximately 18 min. The elimination of this fragrance compound from the blood is biphasic, with a mean distribution half-life of 6.7 min and an elimination half-life of 104.6 min.
authors.affiliation: Department of Radiology, University of Vienna, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Jäger
authors.forename: B
authors.initials: B
authors.lastname: Nasel
authors.forename: C
authors.initials: C
authors.lastname: Nasel
authors.forename: R
authors.initials: R
authors.lastname: Binder
authors.forename: T
authors.initials: T
authors.lastname: Stimpfl
authors.forename: W
authors.initials: W
authors.lastname: Vycudilik
authors.forename: G
authors.initials: G
authors.lastname: Buchbauer
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D003511:Cyclohexanols; D000077591:Eucalyptol; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008610:Menthol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D039821:Monoterpenes; D010476:Perfume; D013729:Terpenes
chemical_list: D003511:Cyclohexanols; D039821:Monoterpenes; D010476:Perfume; D013729:Terpenes; D008610:Menthol; D000077591:Eucalyptol