title: The effect of recombinant human interferon alpha B/D compared to interferon alpha 2b on SIV infection in rhesus macaques.
abstract: The model of simian immunodeficiency virus (SIV) infection in rhesus macaques was used to evaluate the effects of recombinant human interferon alpha, Hu IFN-alpha 2b and Hu IFN-gamma B,D, at two doses. Administration began 1 day prior to infection and was continued for 90 days postinfection. Both interferons suppressed SIV antigenemia during the treatment period. Following treatment animals were monitored for 4 years for rate of disease progression. Neither IFN prolonged the asymptomatic period or survival.
authors.affiliation: Diagnostic Centre SSDZ, Department of Infectious Diseases and Immunology, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Schellekens
authors.forename: H
authors.initials: H
authors.lastname: Niphuis
authors.forename: L
authors.initials: L
authors.lastname: Buijs
authors.forename: P
authors.initials: P
authors.lastname: Douw van der Krap
authors.forename: H K
authors.initials: HK
authors.lastname: Hochkeppel
authors.forename: J L
authors.initials: JL
authors.lastname: Heeney
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000097:blood; D001708:Biopterins / Q000031:analogs & derivatives / Q000097:blood; D018791:CD4 Lymphocyte Count; D015683:Gene Products, gag / Q000097:blood / Q000276:immunology; D006801:Humans; D007370:Interferon Type I / Q000008:administration & dosage / Q000494:pharmacology*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000494:pharmacology*; D008253:Macaca mulatta; D019798:Neopterin; D011994:Recombinant Proteins; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000628:therapy* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000276:immunology; D013997:Time Factors
chemical_list: D000956:Antigens, Viral; C066594:Gag protein p27, Simian immunodeficiency virus; D015683:Gene Products, gag; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D001708:Biopterins; D019798:Neopterin