title: Studies on the effect of fenbendazole and mebendazole on some enzymes of swine kidney worm Stephanurus dentatus.
abstract: The effect of fenbendazole and mebendazole on the activity of some enzymes of the homogenates of swine kidney worm Stephanurus dentatus was investigated. Fenbendazole at 10(-5) M inhibited malate oxidation by 49% and 51% and oxaloacetate reduction by 33% and 40% whereas, mebendazole at 10(-5) M diminished malate oxidation by 25% and 35% and oxaloacetate reduction by 12% and 14% in male and female S. dentatus, respectively. Lactate dehydrogenase activity was inhibited by 45% and 50% in male and female worm respectively by 10(-5) M fenbendazole. Aldolase activity in both male and female S. dentatus was inhibited by 10(-5) M fenbendazole and mebendazole. Fenbendazole at 10(-5) M caused moderate inhibition of acid and alkaline phosphomonoesterases but mebendazole did not show a significant effect on these enzymes. Cholinesterase activity was not affected significantly with either compound. The possible mode of action of the two compounds is compared.
authors.affiliation: Pest and Parasite Research Laboratory, Postgraduate Department of Zoology, Bareilly College, India.
authors.forename: K
authors.initials: K
authors.lastname: Singh
authors.forename: P
authors.initials: P
authors.lastname: Kaushal
mesh_terms: D000429:Alcohol Oxidoreductases / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology*; D002802:Cholinesterases / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005273:Fenbendazole / Q000494:pharmacology*; D005634:Fructose-Bisphosphate Aldolase / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D007674:Kidney Diseases / Q000469:parasitology; D008297:Male; D008463:Mebendazole / Q000494:pharmacology*; D010744:Phosphoric Monoester Hydrolases / Q000187:drug effects / Q000378:metabolism; D017206:Strongylida Infections / Q000378:metabolism / Q000662:veterinary*; D013320:Strongyloidea / Q000201:enzymology* / Q000302:isolation & purification; D013552:Swine; D013553:Swine Diseases / Q000469:parasitology*
chemical_list: D000969:Antinematodal Agents; D005273:Fenbendazole; D008463:Mebendazole; D000429:Alcohol Oxidoreductases; D002802:Cholinesterases; D010744:Phosphoric Monoester Hydrolases; D005634:Fructose-Bisphosphate Aldolase