Primary small cell neuroendocrine carcinoma of the kidney.
The histological, immunohistochemical, and ultrastructural features of a primary small cell neuroendocrine carcinoma of the renal parenchyma are described. Tumor cells were positive for cytokeratin, neuron-specific enolase, and Leu 7, but Grimelius- and chromogranin-negative. They also exhibited positivity with anti-MIC2 antibody. By electron microscopy, tonofibrils, primitive desmosomes, and dense-core granules with a neuroendocrine appearance were present. This is only the 7th recorded example of such a tumor at this site, which showed an aggressive course characterized by widespread bony metastases.
Morgan
K G
KG
Department of Pathology, Christie Hospital NHS Trust, Manchester, United Kingdom.
Banerjee
S S
SS
Eyden
B P
BP
Barnard
R J
RJ
D000328:Adult; D000818:Animals; D018278:Carcinoma, Neuroendocrine / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure*; D018288:Carcinoma, Small Cell / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure*; D051379:Mice