title: Distributional change of alpha-tocopherol in the rat lens with age.
abstract: Concentration of alpha-tocopherol (alpha-Toc.) in the rat lens (1, 4 and 12 months old) was determined in single lenticular layers using gas chromatography and mass spectrometry. The highest concentration of alpha-Toc. in lens was found in the nucleus, followed by the deeper anterior and deeper posterior cortices, the shallow anterior and shallow posterior cortices, and the equatorial region. The topographic alpha-Toc. distribution in the lens did not differ between lenses of 1-, 4- and 12-month-old rats. A significant decrease of alpha-Toc. concentration was seen in lenses of 4- and 12-month-old rats compared to those 1 month old. Concentration and distribution in 4- and 12-month-old rat lenses were almost the same. The concentration of alpha-Toc. in the lens changes in relation to age.
authors.affiliation: Department of Ophthalmology, Kanazawa Medical University, Ishikawa, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nagata
authors.forename: M
authors.initials: M
authors.lastname: Kojima
authors.forename: H
authors.initials: H
authors.lastname: Murano
authors.forename: K
authors.initials: K
authors.lastname: Sasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Obara
authors.forename: K
authors.initials: K
authors.lastname: Matsuura
authors.forename: H
authors.initials: H
authors.lastname: Takashina
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D007904:Lens Cortex, Crystalline / Q000378:metabolism*; D007907:Lens Nucleus, Crystalline / Q000378:metabolism*; D051381:Rats; D011914:Rats, Inbred BN; D014810:Vitamin E / Q000378:metabolism*
chemical_list: D014810:Vitamin E