title: Clear cell follicular adenoma of the thyroid: a case report.
abstract: A case of clear cell follicular adenoma of the thyroid is presented. The patient presented with a single, hyperactive nodule in the right lobe. The cytologic features include cellular smears with numerous disrupted cells and a granular background. The cytoplasm was abundant, pale grayblue vacuolated or granulated, but not clear. Thyreoglobulin was demonstrated both histologically and ultrastructurally, confirming the follicular-cell derivation of the tumor. Ultrastructurally, the cytoplasm was filled with empty, membrane bound vacuoles. The clear cell change might represent an artifact of formalin fixation and/or the paraffin embedding procedure.
authors.affiliation: Department of Pathology, Ullevaal University Hospital, Oslo, Norway.
authors.forename: T
authors.initials: T
authors.lastname: Sauer
authors.forename: R
authors.initials: R
authors.lastname: Olsholt
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D013954:Thyroglobulin / Q000032:analysis; D013961:Thyroid Gland / Q000166:cytology* / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D013954:Thyroglobulin