[The effect of erythropoietin on megakaryocytopoiesis depressed by dialysable substances in experimental animals].
The aim of the study is to examine influence of r-Hu-Ero on megakaryocytopoiesis in rats with depressed by dialysable substances thrombocytopoiesis. Experimental animals are male Wistar rats, treated with bidestilled water, used dialysis solution and r-Hu-Ero. We investigate bone marrow of experimental rats. More expressed increase of megakaryocyte count "pro mile" in rats with depressed megakaryocytopoiesis, as well as influence on megakaryocyte maturation for shorter period of time, provide evidence to be accepted that megakaryocytopoiesis, depressed by dialysable substances is more sensitive to stimulating effect of r-Hu-Ero. The reason for this enhanced sensitivity at present appear unclear.
Zorcheva
R
R
Department of Nephrology, Hemodialysis and Hematology, Medical University, Varna.
Nenov
D
D
Diankov
E
E
D000704:Analysis of Variance; D000818:Animals; D003864:Depression, Chemical; D015314:Dialysis Solutions / Q000494:pharmacology*; D004921:Erythropoietin / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D008297:Male; D008533:Megakaryocytes / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000494:pharmacology; D013268:Stimulation, Chemical
D015314:Dialysis Solutions; D011994:Recombinant Proteins; D004921:Erythropoietin