Intracerebroventricular La3+ but not Gd3+ inhibits cocaine-induced motor activation in rats.
In the present work the effects of i.c.v. administration of La3+ and Gd3+ on the motor stimulant effect of cocaine in rats were studied. Both La3+ and Gd3+ failed to influence basal motor activity. However, the two metal ions differ in modulation of cocaine-induced activation of motor activity. While Gd3+ (10.0, 20.0 and 40.0 mM/1 ml) did not influence significantly the cocaine effect, La3+ (0.1, 1.0 and 10 mM/1 ml) inhibited cocaine-induced motor activation in a dose-dependent manner. The results suggest the possible involvement of La(3+)-but not Gd(3+)-sensitive calcium channels in the locomotor stimulant effect of cocaine.
Kuzmin
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AV
Department of Pharmacology, Pavlov Medical University, St.-Petersburg, Russia.
Zwartau
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EE
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003042:Cocaine / Q000494:pharmacology*; D005682:Gadolinium / Q000494:pharmacology*; D007811:Lanthanum / Q000494:pharmacology*; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D007811:Lanthanum; D005682:Gadolinium; D003042:Cocaine