Receptors for gamma-interferon encoded by poxviruses: implications for the unknown origin of vaccinia virus.
Poxviruses encode soluble interferon-gamma receptors (IFN-gamma Rs) that inhibit IFN-gamma activity and play a major role in virus pathogenesis. In contrast to the highly species specific cellular homologues, the vaccinia IFN-gamma R has novel broad species specificity. This has implications for the unknown origin and natural host(s) of vaccinia virus, the vaccine used for smallpox eradication.
Alcamí
A
A
Sir William Dunn School of Pathology, University of Oxford, UK. alcami@molbiol.ox.ac.uk
Smith
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GL
D015703:Antigens, CD / Q000235:genetics*; D000998:Antiviral Agents / Q000494:pharmacology; D005075:Biological Evolution; D005814:Genes, Viral; D007371:Interferon-gamma / Q000494:pharmacology; D008954:Models, Biological; D011212:Poxviridae / Q000145:classification / Q000235:genetics*; D011213:Poxviridae Infections / Q000209:etiology / Q000276:immunology; D017471:Receptors, Interferon / Q000235:genetics*; D012995:Solubility; D014616:Vaccinia virus / Q000145:classification; D014764:Viral Proteins / Q000235:genetics*; D000096743:Interferon gamma Receptor
D015703:Antigens, CD; D000998:Antiviral Agents; D007371:Interferon-gamma; D017471:Receptors, Interferon; D014764:Viral Proteins; D000096743:Interferon gamma Receptor