Widespread ectopic neuropeptide-Y immunoreactivity in contralateral mossy fibres after a unilateral intrahippocampal kainic acid injection in the rat.
Granule cells of the dentate gyrus can express neuropeptide-Y (NPY) in several models of epilepsy involving limbic seizures, however, the nature of this ectopic expression is not well understood at present. We have studied the expression of NPY-immunoreactivity in mossy fibres contralateral to a unilateral intrahippocampal injection of kainic acid and report that ectopic mossy fibre NPY-immunoreactivity is observed throughout the contralateral hippocampus.
Lurton
D
D
Laboratoire de Neurobiologie et Neuro-imagerie, Expérimentales, Université de Bordeaux II 146, France. dominiquelurton100646.3446@compuserve.com
Coussemacq
M
M
Barrow
P
P
Sundstrom
L E
LE
Rougier
A
A
D000818:Animals; D000918:Antibody Specificity; D004827:Epilepsy / Q000503:physiopathology; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology*; D006624:Hippocampus / Q000737:chemistry* / Q000166:cytology / Q000187:drug effects; D007150:Immunohistochemistry; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D008845:Microinjections; D009478:Neuropeptide Y / Q000032:analysis / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar
D018690:Excitatory Amino Acid Agonists; D009478:Neuropeptide Y; D007608:Kainic Acid