title: Identification of sodC encoding periplasmic [Cu,Zn]-superoxide dismutase in Salmonella.
abstract: sodC, encoding [Cu,Zn]-cofactored superoxide dismutase, once thought to be virtually confined to eukaryotes, has now been described in many Gram-negative pathogens that have their primary niche of colonization in the upper respiratory tract. Their role in host-parasite interactive biology is unknown. We here show that members of the major human and animal enteric pathogenic species Salmonella harbour a version of sodC most closely resembling that found in Brucella abortus. The enzyme it encodes is a novel candidate determinant of virulence in Salmonella, an intracellular pathogen potentially exposed to toxic oxygen free radicals within its intracellular niche.
authors.affiliation: Department of Paediatrics, Imperial College School of Medicine at St Mary's, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Canvin
authors.forename: P R
authors.initials: PR
authors.lastname: Langford
authors.forename: K E
authors.initials: KE
authors.lastname: Wilks
authors.forename: J S
authors.initials: JS
authors.lastname: Kroll
mesh_terms: D015139:Blotting, Southern; D002003:Brucella abortus / Q000235:genetics; D016935:Caulobacter crescentus / Q000235:genetics; D017931:DNA Primers / Q000235:genetics; D006190:Haemophilus / Q000235:genetics; D008969:Molecular Sequence Data; D010776:Photobacterium / Q000235:genetics; D016133:Polymerase Chain Reaction; D012475:Salmonella / Q000201:enzymology* / Q000235:genetics / Q000472:pathogenicity; D017386:Sequence Homology, Amino Acid; D013482:Superoxide Dismutase / Q000235:genetics*; D014774:Virulence
chemical_list: D017931:DNA Primers; D013482:Superoxide Dismutase