[Role of substitution albumin therapy in drugs, hormones, electrolytes and miscellanous substances transport].
Human serum albumin (HSA) is quantitatively the most important non specific transport protein. HSA binds a wide variety of both endogenous and exogenous ligands. Hypoalbuminaemia may lead to a decreased plasma binding capability of some compounds. Biological/pharmacological consequences depend on the ligand and the target tissue. Many experimental studies suggest that hypoalbuminaemia may influence the metabolism and toxicity of endogenous ligands (bilirubin, metallic ions, oxygen radicals) and the pharmacological effect of some drugs (among others: furosemide, phenytoin, warfarin). The relevance of such information for human surgical situations remains unclear. Clinical studies are scarce and inconclusive. There is a lack of pertinent data supporting the necessity of HSA infusions in order to maintain a minimal plasma concentration and a convenient plasma transport. However, experimental data indicate that major hypoalbuminaemia should be considered with caution.
Ozier
Y
Y
Service d'anesthésie-réanimation chirurgicale, université René-Descartes, Paris V, France.
D000818:Animals; D001663:Bilirubin / Q000378:metabolism; D001692:Biological Transport; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D008024:Ligands; D016877:Oxidants / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D012709:Serum Albumin / Q000378:metabolism*
D006728:Hormones; D018836:Inflammation Mediators; D008024:Ligands; D016877:Oxidants; D004364:Pharmaceutical Preparations; D012709:Serum Albumin; D001663:Bilirubin