title: Surgical treatment of infected thoracic and abdominal aortic aneurysms.
abstract: Twelve patients with infected aneurysms of the thoracic and abdominal aorta were evaluated. Aneurysmal location, aetiology, bacteriology and treatment modality were analysed to determine the relationship between these factors and outcome. Patients were divided into two groups based on the preoperative states of their infections. Group 1 patients (n = 7) underwent resection after resolution of their active infection. The causative organisms included Staphylococcus epidermidis (two cases). Salmonella spp. (one). Acinetobacter (one), Mycobacterium tuberculosis (one) and unknown organisms (two). Group 2 patients (n = 5) required urgent surgery because of uncontrolled sepsis despite intensive treatment with antibiotics. The causative organisms included Staphylococcus aureus (two cases). Pseudomonas aeruginosa (two) and Salmonella spp. (one). In group 1, three patients underwent closed en bloc excision of the aneurysm with in-situ graft replacement, and four underwent partial resection with in-situ graft replacement. In group 2, three patients underwent resection of the aneurysm with ligation of aorta and extra-anatomic bypass, and two underwent in-situ graft replacement after débridement of infected tissue. Overall, patients in group 1 had a mortality rate of 14% compared with 80% in group 2. These results suggest that the operative approach and method chosen to restore arterial continuity have less of an impact on outcome. The primary determinants of outcome are virulence of the infecting organism and the preoperative state of the infection.
authors.affiliation: Second Department of Surgery, Fukui Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Chiba
authors.forename: R
authors.initials: R
authors.lastname: Muraoka
authors.forename: A
authors.initials: A
authors.lastname: Ihaya
authors.forename: T
authors.initials: T
authors.lastname: Kimura
authors.forename: K
authors.initials: K
authors.lastname: Morioka
authors.forename: M
authors.initials: M
authors.lastname: Nara
authors.forename: H
authors.initials: H
authors.lastname: Niwa
mesh_terms: D000151:Acinetobacter Infections / Q000401:mortality / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D000785:Aneurysm, Infected / Q000401:mortality / Q000601:surgery*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017544:Aortic Aneurysm, Abdominal / Q000401:mortality / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000401:mortality / Q000601:surgery*; D001019:Aortic Rupture / Q000401:mortality / Q000601:surgery; D001807:Blood Vessel Prosthesis; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011552:Pseudomonas Infections / Q000401:mortality / Q000601:surgery; D011550:Pseudomonas aeruginosa; D012480:Salmonella Infections / Q000401:mortality / Q000601:surgery; D013203:Staphylococcal Infections / Q000401:mortality / Q000601:surgery; D015996:Survival Rate; D014381:Tuberculosis, Cardiovascular / Q000401:mortality / Q000601:surgery
chemical_list: D000900:Anti-Bacterial Agents