title: Age and gender-related incidence of chronic renal failure in a French urban area: a prospective epidemiologic study.
abstract: OBJECTIVE
  To determine the age- and gender-related incidence of chronic renal failure in a French urban area.
  
  
  METHODS
  Prospective study of adult patients newly identified as having established, chronic renal failure defined by serum creatinine (Scr) > or = 200 mumol/l, with the cooperation of all nephrology and dialysis units in the Ile de France district (10,660,000 inhabitants) during a 1-year period.
  
  
  RESULTS
  2775 patients (1780 males, 995 females) were referred with Scr > or = 200 mumol/l between July 1991 and June 1992, an overall incidence of 260/million population. 847 had advanced renal failure (Scr > or = 500 mumol/l) and 541 patients (19.5%) were > or = 75 years of age. The age-related incidence was 92, 264, 523 and 619/million population in the age groups 20-39, 40-59, 60-74 and > or = 75 years old, respectively. The annual incidence was twice as high in males than in females up to 75 years and three times as high in patients > or = 75 years (1124 vs 356/million population). Based on the proportion of patients reaching end-stage renal failure within one year of referral, the minimal estimation of the need for supportive therapy is 81/million/year.
  
  
  CONCLUSIONS
  This epidemiological study in a large French urban area indicates an incidence of 260 patients per million population annually referred to nephrology units for chronic renal failure defined by Scr > or = 200 mumol/l, with a marked preponderance of males and a dramatic increase of incidence with age in both genders.
authors.affiliation: Department of Nephrology, Necker Hospital, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Jungers
authors.forename: P
authors.initials: P
authors.lastname: Chauveau
authors.forename: B
authors.initials: B
authors.lastname: Descamps-Latscha
authors.forename: M
authors.initials: M
authors.lastname: Labrunie
authors.forename: E
authors.initials: E
authors.lastname: Giraud
authors.forename: N K
authors.initials: NK
authors.lastname: Man
authors.forename: J P
authors.initials: JP
authors.lastname: Grünfeld
authors.forename: C
authors.initials: C
authors.lastname: Jacobs
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D005260:Female; D005602:France; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000453:epidemiology*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D012737:Sex Factors; D014504:Urban Health