A novel monogalactosylacylglycerol with inhibitory effect on platelet aggregation from the cyanophyceae Oscillatoria rosea.
(2S)-1-O-Palmitoyl-3-O-beta-D-galactopyranosylglycerol, isolated from the marine alga Oscillatoria rosea, inhibited platelet aggregation induced by U46619, a thromboxane A2 analogue. Its structure was elucidated by spectroscopic analysis and chemical evidence.
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Department of Pharmaceutical Molecular Biology, Tohoku University, Sendai, Japan.
Matsunaga
K
K
Yasuda
K
K
Ohizumi
Y
Y
D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D000818:Animals; D000458:Cyanobacteria / Q000737:chemistry / Q000378:metabolism*; D004354:Drug Screening Assays, Antitumor; D005697:Galactosides / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D006868:Hydrolysis; D066298:In Vitro Techniques; D015759:Ionomycin / Q000494:pharmacology; D007476:Ionophores / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy; D008244:Lysophosphatidylcholines / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D011450:Prostaglandin Endoperoxides, Synthetic / Q000037:antagonists & inhibitors / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013928:Thromboxane A2 / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology
C102720:1-O-palmitoyl-3-galactopyranosylglycerol; D005697:Galactosides; D007476:Ionophores; D008244:Lysophosphatidylcholines; D010975:Platelet Aggregation Inhibitors; D011450:Prostaglandin Endoperoxides, Synthetic; D015759:Ionomycin; D013928:Thromboxane A2; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid