The role of magnetic resonance spectroscopy in the investigation of lactic acidosis and inborn errors of energy metabolism.
Magnetic resonance spectroscopy (MRS) provides a non-invasive method of investigating disordered energy metabolism in vivo. Here, we briefly outline some MRS studies of skeletal muscle and brain metabolism that have been carried out in patients with inborn errors of energy metabolism. We concentrate in particular on the use of 1H MRS for the detection of elevated brain lactate in these patients.
Gadian
D G
DG
Radiology and Physics Unit, Institute of Child Health, London, UK.
Leonard
J V
JV
D000140:Acidosis, Lactic / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D004734:Energy Metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008661:Metabolism, Inborn Errors / Q000378:metabolism* / Q000628:therapy; D009132:Muscles / Q000378:metabolism