title: [Perfusion studies with paramagnetic contrast media and rapid pulse sequences in cerebrovascular diseases and brain tumors].
abstract: The combination of fast MR sequences and rapid i.v. injection of paramagnetic contrast media provides information on cerebral perfusion. MR-perfusion imaging primarily depicts the relative cerebral blood volume. The aim of this study was to test whether MR-perfusion imaging with a clinical MR scanner using a standard 2D-FLASH sequence provides clinically relevant information on patients with cerebrovascular diseases and brain tumors. Brain infarctions, lesions in cerebral microangiopathy and occlusions of the carotid artery with very poor collateralization showed definite differences in perfusion imaging compared with normal controls. However, our results show that acceleration of the imaging sequence and optimization of the contrast bolus and data processing are prerequisites for the clinical use of this method, which in principle may provide information on the absolute cerebral blood volume and even blood flow.
authors.affiliation: Institut für Klinische Radiologie, Westfälische Wilhelms-Universität Münster.
authors.forename: G
authors.initials: G
authors.lastname: Schuierer
authors.forename: P
authors.initials: P
authors.lastname: Reimer
authors.forename: A
authors.initials: A
authors.lastname: Tigges
authors.forename: P E
authors.initials: PE
authors.lastname: Peters
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001810:Blood Volume / Q000502:physiology; D001921:Brain / Q000098:blood supply*; D001932:Brain Neoplasms / Q000098:blood supply* / Q000175:diagnosis; D002561:Cerebrovascular Disorders / Q000175:diagnosis*; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged
chemical_list: D003287:Contrast Media