Synthesis and biological evaluation of proline derivatives as potential angiotensin converting enzyme inhibitor.
The synthesis of a series of proline derivatives (1a-e and 2a-b) as pure isomers is described. These compounds were evaluated in vitro for their ability to inhibit angiotensin converting enzyme (ACE) and compared to the potency of captopril taken as a reference drug. They showed only a weak ACE inhibitory activity.
Giugliano
G
G
Dipartimento di Chimica Farmaceutica e Tossicologica, Università degli Studi di Napoli.
Grieco
P
P
Ialenti
A
A
Mottola
M
M
Perissutti
E
E
Santagada
V
V
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D009842:Oligopeptides / Q000378:metabolism; D011392:Proline / Q000031:analogs & derivatives* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000806:Angiotensin-Converting Enzyme Inhibitors; D009842:Oligopeptides; C010980:hippuryl-histidyl-leucine; D011392:Proline