title: Effects of angiotensin II on brain monoamine oxidase activity in non-hypoxic and hypoxic mice.
abstract: The effects of angiotensin II (ATII) administered intracerebroventricularly (i.c.v.) at a dose of 0.5 microgram per mouse on the activity of monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) in the forebrain of normoxic and hypoxic mice were studied. The influence of hypoxia (asphyctic and haemic) on MAO-A and MAO-B activity was also investigated. MAO-A activity was increased in haemic hypoxia; MAO-B activity increased in both asphyctic and haemic hypoxia. ATII increased MAO-A activity without affecting MAO-B activity under normoxic conditions. ATII increased MAO-A activity but decreased MAO-B in hypoxic (asphyctic) mice as compared to normoxic controls. The results suggest the role of MAO-A and MAO-B in the ATII-induced increase of susceptibility to acute hypoxia.
authors.affiliation: Institute of Physiology, Bulgarian Academy of Sciences, Bulgaria.
authors.forename: S
authors.initials: S
authors.lastname: Stancheva
authors.forename: V
authors.initials: V
authors.lastname: Georgiev
authors.forename: L
authors.initials: L
authors.lastname: Alova
authors.forename: D
authors.initials: D
authors.lastname: Getova
mesh_terms: D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001237:Asphyxia / Q000201:enzymology; D001921:Brain / Q000187:drug effects / Q000201:enzymology* / Q000502:physiology; D000860:Hypoxia / Q000097:blood / Q000201:enzymology*; D007276:Injections, Intraventricular; D007527:Isoenzymes / Q000378:metabolism*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008995:Monoamine Oxidase / Q000378:metabolism*; D016548:Prosencephalon / Q000187:drug effects / Q000201:enzymology
chemical_list: D007527:Isoenzymes; D000804:Angiotensin II; D008995:Monoamine Oxidase