The effect of intravenous metoclopramide on blood pressure in normotensive and hypertensive subjects.
In the present study we evaluated the effect of intravenous metoclopramide on blood pressure in normotensive (untrained, football players, runners) and hypertensive subjects. There was a decrease in blood pressure only observed in untrained female subjects and this was greater in hypertensive subjects. In football players and runners the decrease in blood pressure was not statistically significant. There was no significant effect on heart rate. The probable mechanism of this new pharmacological effect of metoclopramide is unknown, however, research is now in progress to define its mechanism of action.
Blanco
M
M
Clinical Pharmacology Unit, Vargas Medical School, Central University of Venezuela, Caracas, SA.
Jelambi
I
I
Pérez
G
G
Gómez
J
J
Franco
T
T
Hurtado
N
N
Velasco
M
M
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D018492:Dopamine Antagonists / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007262:Infusions, Intravenous; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D008875:Middle Aged
D018492:Dopamine Antagonists; D008787:Metoclopramide