Synthesis and antitumor activity evaluation of Delta2-1,2,4-oxadiazoline derivatives.
4-Adamantyl-5-aryl-3-phenyl-Delta2-1,2,4-oxadiazolines were synthesized and evaluated in vitro as antitumor agents against 60 human tumor cell lines. Some derivatives exhibit both cell selectivity and tumor growth inhibition activity. In particular, 2,6-dichlorophenyl derivative (2q), the most active of the series, possesses significant activity on 26 cell lines at 10(-5) M.
Chimirri
A
A
Dipartimento Farmaco-Chimico, Universita di Messina, Italy.
Grasso
S
S
Monforte
A M
AM
Rao
A
A
Zappala
M
M
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D010069:Oxadiazoles