Localization of mRNA for leukemia inhibitory factor receptor in the adult rat brain.
The distribution of leukemia inhibitory factor receptor (LIFR) mRNA in the adult rat brain was examined by in situ hybridization technique. The intense signals of LIFR mRNA were restricted to specific brain regions relevant to the motor and sensory systems. The moderate expression of LIFR mRNA was observed in several brain regions, including the cerebral cortex, hippocampus, thalamus, hypothalamus and cerebellum. Most of the signals of LIFR mRNA were detected on likely neuronal cells. These findings suggest the possibility that LIF has potential actions on the neuronal cells in the central nervous system of the adult rat.
Yamakuni
H
H
Department of Molecular Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Minami
M
M
Satoh
M
M
D000818:Animals; D001921:Brain / Q000648:ultrastructure; D001923:Brain Chemistry; D005727:Ganglia, Spinal / Q000737:chemistry; D006131:Growth Inhibitors; D017403:In Situ Hybridization; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D053680:Leukemia Inhibitory Factor Receptor alpha Subunit; D008222:Lymphokines; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics*; D016133:Polymerase Chain Reaction; D015347:RNA Probes; D018075:RNA, Complementary / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018121:Receptors, Cytokine / Q000096:biosynthesis / Q000235:genetics*; D053606:Receptors, OSM-LIF; D013116:Spinal Cord / Q000737:chemistry
D006131:Growth Inhibitors; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D053680:Leukemia Inhibitory Factor Receptor alpha Subunit; C507842:Lifr protein, rat; D008222:Lymphokines; D009419:Nerve Tissue Proteins; D015347:RNA Probes; D018075:RNA, Complementary; D012333:RNA, Messenger; D018121:Receptors, Cytokine; D053606:Receptors, OSM-LIF