Histopathology of subacute renal lesions in mice induced by streptozotocin.
Streptozotocin (SZ) was inoculated intraperitoneally to male and female mice of ICR and BALB/c strains in a different way of administration (A: single injection and B consecutive 5 days-injection) and subacute renal changes were examined light and electron microscopically 8 weeks after SZ-administration. The following changes were detected: (1) reduction in the rate of male-type Bowman's capsules in male mice, (2) karyocytomegaly of proximal tubular epithelial cells, and (3) dilation of distal tubules Tubular changes were detected with high incidence in A (males and females) and B groups (males) of ICR strain.
Itagaki
S
S
Department of Veterinary Medical Science, Faculty of Agriculture, University of Tokyo, Japan.
Nishida
E
E
Lee
M J
MJ
Doi
K
K
D000818:Animals; D005260:Female; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects* / Q000473:pathology* / Q000648:ultrastructure; D007674:Kidney Diseases / Q000473:pathology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D013311:Streptozocin / Q000008:administration & dosage / Q000633:toxicity*
D013311:Streptozocin