title: A gene correlate of geotaxis near Adh (2-50.1) in Drosophila melanogaster.
abstract: As part of a long-term study (38+ years) to identify genetic correlates of geotaxis in Drosophila melanogaster, the investigators report the results of allozyme-level analyses of 2 lines derived from hybridizing high- and low-selected lines that have evolved stable, extreme expressions of geotaxis. Allelic variation at Adh was associated with geotactic performance in 1 hybrid-derived line, but not in another, after 66 free-mating generations beyond the F2 generation. A second-chromosome gene correlate of geotaxis may lie within 1 map unit of Adh. Population genetic analyses suggest that there were different selection pressures on the hybrid-derived lines and that the fixation of PGD-A in the high-geotaxis line was probably due to a founder-effect event.
authors.affiliation: Department of Psychology, University of Illinois at Urbana-Champaign, USA.
authors.forename: S F
authors.initials: SF
authors.lastname: Stoltenberg
authors.forename: J
authors.initials: J
authors.lastname: Hirsch
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000681:Amylases / Q000235:genetics; D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006112:Gravitation; D007527:Isoenzymes / Q000235:genetics; D008297:Male; D008957:Models, Genetic; D009949:Orientation / Q000502:physiology*; D010734:Phosphogluconate Dehydrogenase / Q000235:genetics
chemical_list: D007527:Isoenzymes; D000426:Alcohol Dehydrogenase; D010734:Phosphogluconate Dehydrogenase; D000681:Amylases