title: Odor perception phenotypes: multiple, specific hyperosmias to musks.
abstract: Olfactory detection thresholds for 11 structurally diverse musk odorants and one non-musk odorant were obtained from 32 subjects. Hierarchical cluster analysis produced four groups of subjects. One group (n = 12) was uniformly sensitive to all musks; another (n = 16) was uniformly insensitive. Two groups of subjects contained otherwise insensitive individuals who were exceptionally sensitive to cyclopentadecanone and musk xylol (n = 2) and to delta9-hexadecenolactone and tonalid (n = 2) respectively. We propose that the latter two groups are odor perception phenotypes (MSHM1 and MSHM2) that consist of multiple, specific hyperosmias to musk odorants.
authors.affiliation: Givaudan-Roure Fragrances, Teaneck, NJ 07666, USA.
authors.forename: A N
authors.initials: AN
authors.lastname: Gilbert
authors.forename: S E
authors.initials: SE
authors.lastname: Kemp
mesh_terms: D000328:Adult; D016000:Cluster Analysis; D005260:Female; D006801:Humans; D008297:Male; D009812:Odorants; D010476:Perfume; D010641:Phenotype; D012678:Sensation Disorders / Q000235:genetics*; D012903:Smell / Q000235:genetics*
chemical_list: D010476:Perfume