title: Hospitalized dysentery cases during an outbreak of Shigella dysenteriae type I: Ndanga District Hospital, Zimbabwe.
abstract: OBJECTIVE
  To describe the characteristics of patients admitted with bloody diarrhoea; to assess clinical management; and to identify organisms isolated in laboratories and their antimicrobial susceptibility pattern.
  
  
  METHODS
  This was a retrospective study which used data from case files of patients admitted for dysentery at Ndanga District Hospital. The three admission registers from the hospitals male, female and paediatric wards were examined for patients with dysentery as their admitting diagnosis from December 1993 to February 1994. Using case file numbers from the admission registers, we retrieved case files from the records office.
  
  
  METHODS
  Ndanga District Hospital in Zaka, Masvingo Province, Zimbabwe.
  
  
  METHODS
  All patients admitted for dysentery at Ndanga District Hospital.
  
  
  METHODS
  Patients sex, age, clinical presentation, complications, drugs given, culture results, and antimicrobial susceptibility, duration of stay and outcome.
  
  
  RESULTS
  The peak admission period was the last week of January, during which 17 patients were admitted with bloody diarrhoea. The age distribution of cases was bimodal, children less than five and those 15 to 29 being most likely to be hospitalized; 52pc of the patients were females. Signs and symptoms recorded were bloody diarrhoea 100pc, abdominal pain 45pc, dehydration 38pc, fever 34pc, vomiting 26pc, loss of appetite 20pc, weight loss 17pc and anaemia 5pc. Shigella dysenteriae type 1 (SD1) was isolated in 80pc of the 58 stools examined. Most cases were treated with kanamycin (67pc),nitrofurantion (61pc), and metronidazole (43pc). The average number of antibiotics given per patient was 2.3. Seventeen cases developed complications and four patients died, one each with renal failure, haemolytic uraemic syndrome, and severe anaemia. The other patient who died had developed rectal prolapse.
  
  
  CONCLUSIONS
  80pc of the patients in the study received multiple antibiotics. The most frequently used drugs were kanamycin and nitrofurantion, yet neither of these drugs has been shown to be effective in treating dysentery. While the organisms were largely sensitive to nalidixic acid, little of that was prescribed, almost certainly because it was not available until late in the study period. There is need for adherence to the Ministry's recommended dysentery treatment guideline: prompt treatment with an effective antimicrobial to which the organism has been recently shown to be sensitive, and supportive care and prompt referral if complications arise.
authors.affiliation: Zimbabwe Republic Police Medical Services, Police General Headquarters, Causeway, Harare, Zimbabwe.
authors.forename: W S
authors.initials: WS
authors.lastname: Mudzamiri
authors.forename: M
authors.initials: M
authors.lastname: L'Herminez
authors.forename: D E
authors.initials: DE
authors.lastname: Peterson
authors.forename: P
authors.initials: P
authors.lastname: Nhindiri
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004196:Disease Outbreaks; D004405:Dysentery, Bacillary / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D006760:Hospitalization; D006767:Hospitals, District; D006801:Humans; D017053:Infection Control; D007902:Length of Stay; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome; D015030:Zimbabwe
chemical_list: D000900:Anti-Bacterial Agents