Analysis of ibuprofen in serum by capillary electrophoresis.
A rapid method for analysis of the analgesic drug ibuprofen in serum by capillary zone electrophoresis in a borate buffer 160 mmol/l pH 8.5 is described. The method involves deproteinization with acetonitrile to remove serum proteins followed by direct injection on the capillary. The recoveries of standards added to the serum were 84-92%. The method is suited for analysis of samples with concentrations > 10 mg/l. Many other analgesics such as ketoprofen, daypro and salicylates can also be determined by this method.
Shihabi
Z K
ZK
Department of Pathology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157, USA.
Hinsdale
M E
ME
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood*; D019075:Electrophoresis, Capillary / Q000379:methods*; D006801:Humans; D007052:Ibuprofen / Q000097:blood*; D013056:Spectrophotometry, Ultraviolet
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen