title: Relation between infection with human papilloma viruses and expression of p21 and p53 oncoproteins in patients with cancer of the uterine cervix.
abstract: Infection with HPV type 16 was demonstrated in 54% of the cases and infection with HPV type 18 in 36.5% of the cases of uterine cervix carcinoma. Both types of viruses were present in 24.3% of the patients. P53 protein accumulation in cell nuclei was observed in 12.2% of the cases of uterine cervix carcinomas and the cases were mostly HPV negative while the cytoplasmic expression of p53 protein was present in 39% of the cases and was frequently accompanied by HPV infection. Presence of p21 protein was detected in 85.3% of the cases, independently of HPV infection or expression of p53 protein.
authors.affiliation: Chair of Oncology, Faculty of Medicine, K. Marcinkowski University School of Medicine Poznań, Poland.
authors.forename: J K
authors.initials: JK
authors.lastname: Bar
authors.forename: J
authors.initials: J
authors.lastname: Markowska
authors.forename: A
authors.initials: A
authors.lastname: Harlozińska
authors.forename: P
authors.initials: P
authors.lastname: Sedlaczek
authors.forename: M
authors.initials: M
authors.lastname: Nowak
authors.forename: A
authors.initials: A
authors.lastname: Roszak
mesh_terms: D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D015689:Oncogene Protein p21(ras) / Q000378:metabolism*; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000378:metabolism* / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D014412:Tumor Virus Infections / Q000378:metabolism* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000821:virology*
chemical_list: D016159:Tumor Suppressor Protein p53; D015689:Oncogene Protein p21(ras)