Malignant fibrous histiocytoma of the pancreas.
An extremely rare case of malignant fibrous histiocytoma in the pancreas is reported. A 70-year-old man complained of upper abdominal discomfort. A tumor in the head of the pancreas was demonstrated by ultrasonography and computed tomography. The surgical specimen revealed a relatively well demarcated tumor, 9 x 7 x 6.5 cm in size. Microscopically, fibroblastic, histiocytic, and multinucleated giant tumor cells were observed in the myxoid area, but some tumor cells had proliferated in a storiform-pleomorphic pattern. Immunohistochemically, some tumor cells were positive for lysozyme, alpha-1-antitrypsin, alpha-1-antichymotrypsin, and vimentin. Electron microscopically, tumor cells showed a combination of fibroblastic and histiocytic features. The patient is currently well with no evidence of recurrence or metastasis 22 months after operation.
Haba
R
R
Clinical Pathology Laboratory, Saiseikai Imabari Hospital, Japan.
Kobayashi
S
S
Hirakawa
E
E
Miki
H
H
Okino
T
T
Kurokawa
T
T
Yamamoto
S
S
D000368:Aged; D018219:Histiocytoma, Benign Fibrous / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010190:Pancreatic Neoplasms / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure