title: Splenectomy in patients with sickle-cell disease.
abstract: BACKGROUND
  Splenic complications of sickle-cell disease (SCD) are associated with morbidity, and in some it may lead to mortality. This paper presents our experience with 43 patients with SCD who had splenectomy as part of their management.
  
  
  METHODS
  The records of 43 patients with SCD who had splenectomy were examined for age at operation, sex, hemoglobin (Hb) electrophoresis, indication for splenectomy, pre- and postoperative medications, operative procedures, and postoperative complications.
  
  
  RESULTS
  The indications for splenectomy were acute splenic sequestration crisis (ASSC) in 21 patients, hypersplenism in 15, and splenic abscess in 7. In 17 patients, the spleen was also found to be massively enlarged causing discomfort and intervening with everyday activity. For those with hypersplenism, there was a significant postoperative increase in total Hb (P < 0.0001), hematocrit (P < 0.0001), white blood cells (P < 0.0001), and platelet count (P < 0.0001).
  
  
  CONCLUSIONS
  With careful perioperative management and proper follow-up, splenectomy in patients with SCD is beneficial in reducing their transfusion requirements and its attendant risks, eliminating the discomfort from mechanical pressure of the enlarged spleen, avoiding the risks of ASSC, and managing splenic abscess.
authors.affiliation: Department of Surgery, Qatif Central Hospital, Saudi Arabia.
authors.forename: A H
authors.initials: AH
authors.lastname: al-Salem
authors.forename: S
authors.initials: S
authors.lastname: Qaisaruddin
authors.forename: Z
authors.initials: Z
authors.lastname: Nasserallah
authors.forename: I
authors.initials: I
authors.lastname: al Dabbous
authors.forename: A
authors.initials: A
authors.lastname: al Jam'a
mesh_terms: D000038:Abscess / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood / Q000150:complications*; D001772:Blood Cell Count; D002648:Child; D002675:Child, Preschool; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D006971:Hypersplenism / Q000150:complications / Q000601:surgery; D008297:Male; D013156:Splenectomy; D013158:Splenic Diseases / Q000150:complications / Q000601:surgery*
chemical_list: D006454:Hemoglobins