100,000 quinacrine sterilizations.
100000 quinacrine nonsurgical female sterilizations have been completed over the past decade involving transcervical insertion of quinacrine (252 mg) as pellets by one, two or three monthly insertions. No deaths have been reported and serious complications are far fewer than for surgical sterilization. Side-effects are mild and transient. Efficacy has improved from 3 pregnancy failures per 100 women at one year to approximately 1 by improved insertion technique and use of adjuvants. Long-term follow-up of early cases in Chile shows no increased risk of cancer for this method. The main advantage of quinacrine sterilization is its ability to raise contraceptive prevalence and thereby reduce maternal mortality and morbidity, especially in rural and urban slum areas of developing countries. It should be made available as an option to well informed women everywhere as an economical and safe permanent family planning method.
Kessel
E
E
Department of Public Health and Preventive Medicine, Oregon Health Sciences University, Portland 97201, USA.
D019049:Developed Countries; D003906:Developing Countries; D004343:Drug Implants; D005260:Female; D006801:Humans; D011247:Pregnancy; D011796:Quinacrine / Q000008:administration & dosage / Q000009:adverse effects; D015203:Reproducibility of Results; D018570:Risk Assessment; D012449:Safety; D013245:Sterilization, Reproductive / Q000379:methods* / Q000401:mortality
D004343:Drug Implants; D011796:Quinacrine