Cardiotrophin-1: a multifunctional cytokine that signals via LIF receptor-gp 130 dependent pathways.
In a search for novel factors that induce cardiac myocyte hypertrophy, cardiotrophin-1 (CT-1) was identified by coupling expression cloning with an embryonic stem cell-based model of cardiogenesis. CT-1 is a new member of the IL-6 family of cytokines that induce their biological effects through the shared signaling subunit, gp 130. The expression pattern of CT-1 and its range of activities in the hematopoietic, neuronal, and developmental assays suggest that CT-1 may play an important role in other organ systems, in addition to its actions in cardiac development and hypertrophy.
Pennica
D
D
Department of Molecular Biology, Genentech Inc., South San Francisco, CA 94080-4990, USA.
Wood
W I
WI
Chien
K R
KR
D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD / Q000502:physiology*; D006332:Cardiomegaly / Q000473:pathology / Q000503:physiopathology; D002478:Cells, Cultured; D050822:Cytokine Receptor gp130; D016207:Cytokines / Q000235:genetics / Q000502:physiology*; D006131:Growth Inhibitors; D006801:Humans; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D053680:Leukemia Inhibitory Factor Receptor alpha Subunit; D008222:Lymphokines / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000502:physiology*; D008969:Molecular Sequence Data; D018121:Receptors, Cytokine / Q000502:physiology*; D053606:Receptors, OSM-LIF; D015398:Signal Transduction / Q000502:physiology*
D015703:Antigens, CD; D016207:Cytokines; D006131:Growth Inhibitors; C494199:IL6ST protein, human; D015850:Interleukin-6; C507837:LIF protein, human; C507840:LIFR protein, human; D053605:Leukemia Inhibitory Factor; D053680:Leukemia Inhibitory Factor Receptor alpha Subunit; D008222:Lymphokines; D008562:Membrane Glycoproteins; D018121:Receptors, Cytokine; D053606:Receptors, OSM-LIF; D050822:Cytokine Receptor gp130; C092073:cardiotrophin 1