title: Multiple ocular impairment in a patient affected by Waldenström's macroglobulinaemia.
abstract: BACKGROUND
  We studied a bilateral tumefaction of the lacrimal gland in a female patient.
  
  
  METHODS
  Ocular and general clinical examinations were carried out.
  
  
  RESULTS
  Computerized tomography (CT) of the cranial orbit showed a tumefaction of solid density in the lacrimal gland. Histological examination of material removed by needle aspiration revealed the presence of elements of a lymphoplasmacytoid nature. Fluorescein angiography showed dilatation of the veins, intraretinal flame haemorrhages and small ischaemic areas. Chest CT showed an increase in the size of the middle and upper mediastinal lymph nodes, and examination of a specimen of bone marrow from the chest revealed the presence of small lymphocytes with a plasmacytoid tendency.
  
  
  CONCLUSIONS
  On the basis of the findings, we diagnosed Waldenström's disease with rare multiple ocular impairment (lacrimal gland and retina) in an early stage.
authors.affiliation: Divisione Oculistica, Ospedale Fatebenefratelli, Isola Tiberina, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Leone
authors.forename: V
authors.initials: V
authors.lastname: Parisi
authors.forename: A
authors.initials: A
authors.lastname: Rebecchi
authors.forename: C
authors.initials: C
authors.lastname: Guinetti
authors.forename: R
authors.initials: R
authors.lastname: Neuschuler
mesh_terms: D000368:Aged; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000150:complications* / Q000175:diagnosis; D009915:Orbit / Q000000981:diagnostic imaging; D012164:Retinal Diseases / Q000150:complications* / Q000175:diagnosis; D014057:Tomography, X-Ray Computed; D008258:Waldenstrom Macroglobulinemia / Q000150:complications* / Q000175:diagnosis