Cardiac kallikrein in hypertensive and normotensive rats with and without diabetes.
This study examined the effects of streptozotocin-induced diabetes on blood pressure and cardiac tissue kallikrein levels in WKYR and SHR. Streptozotocin-induced diabetes caused significant (p < 0.001) increase in SBP and DBP in WKYR and SHR as compared with their respective controls. We also observed that the active cardiac tissue kallikrein levels reduced greatly (p < 0.001) in diabetic WKYR and SHR than the normal rats. These findings suggest for the first time that the cardiac tissue kallikrein formation may have a greater role in the regulation of blood pressure and cardiac function.
Sharma
J N
JN
Department of Pharmacology, School of Medical Sciences, University Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Kesavarao
U
U
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000378:metabolism* / Q000503:physiopathology; D006029:Glycosuria / Q000209:etiology; D006321:Heart / Q000503:physiopathology; D006973:Hypertension / Q000150:complications* / Q000378:metabolism* / Q000503:physiopathology; D016234:Kallikrein-Kinin System / Q000502:physiology; D007610:Kallikreins / Q000378:metabolism* / Q000502:physiology; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D007610:Kallikreins