Coenzyme Q depletion in rat plasma after partial hepatectomy.
Coenzyme Q content was monitored in blood plasma and regenerating liver mitochondria of hepatectomized rats, using as controls either sham-operated or non-operated animals. Mitochondrial CoQ9 content increased in sham-operated rats, whilst it was significantly lower in hepatectomized in comparison with non-operated animals at all considered times. On the other hand plasma CoQ9 levels dramatically decreased in hepatectomized animals, while strongly increased in sham-operated in comparison with non-operated rats. The quinone decrease in hepatectomized animals is likely to be due to the attainment of a rate-limiting step in CoQ biosynthesis.
Formiggini
G
G
Department of Biochemistry G. Moruzzi, University of Bologna, Italy.
Castelluccio
C
C
Pich
M M
MM
Genova
M L
ML
Bovina
C
C
Marchetti
M
M
Lenaz
G
G
D000818:Animals; D003067:Coenzymes; D006498:Hepatectomy; D008115:Liver Regeneration; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000097:blood*
D003067:Coenzymes; D014451:Ubiquinone; C024989:coenzyme Q10; C030571:ubiquinone 9