Anti-inflammatory and radical scavenge effects of Arctium lappa.
The effects of Arctium lappa L. (root) on anti-inflammatory and free radical scavenger activity were investigated. Subcutaneous administration of A. lappa crude extract significantly decreased carrageenan-induced rat paw edema. When simultaneously treated with CCl4, it produced pronounced activities against CCl4-induced acute liver damage. The free radical scavenging activity of its crude extract was also examined by means of an electron spin resonance (ESR) spectrometer. The IC50 of A. lappa extract on superoxide and hydroxyl radical scavenger activity was 2.06 mg/ml and 11.8 mg/ml, respectively. These findings suggest that Arctium lappa possess free radical scavenging activity. The inhibitory effects on carrageenan-induced paw edema and CCl4-induced hepatotoxicity could be due to the scavenging effect of A. lappa.
Lin
C C
CC
Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan.
Lu
J M
JM
Yang
J J
JJ
Chuang
S C
SC
Ujiie
T
T
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002251:Carbon Tetrachloride / Q000008:administration & dosage / Q000633:toxicity; D002351:Carrageenan / Q000008:administration & dosage / Q000633:toxicity; D004487:Edema / Q000188:drug therapy*; D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers / Q000494:pharmacology* / Q000627:therapeutic use; D017665:Hydroxyl Radical / Q000378:metabolism; D007279:Injections, Subcutaneous; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D051381:Rats; D017208:Rats, Wistar; D013481:Superoxides / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D016166:Free Radical Scavengers; D010936:Plant Extracts; D013481:Superoxides; D017665:Hydroxyl Radical; D002351:Carrageenan; D002251:Carbon Tetrachloride