[Acromegaly].
The diagnosis of acromegaly, in more than 95% linked to a pituitary adenoma, is essentially a clinical dysmorphic syndrome. Because of its low evolution, the illness is too often diagnosed when complications (cardio-respiratory, diabetes...) occur. The biological diagnosis is based on high insulin growth factor 1 (IGF1) and growth hormone (GH) levels which are not suppressed under an oral glucose load. The treatment is mainly surgical (transsphenoidal selective adenomectomy) at first intention. Irradiation and medical treatment (dopaminergic or somatostatinergic drugs) are used in case of surgical failure.
Morange
I
I
Service d'endocrinologie, Centre hospitalo-universitaire de la Timone, Marseille.
Jaquet
P
P
D000172:Acromegaly / Q000150:complications / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D000236:Adenoma / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D000328:Adult; D003920:Diabetes Mellitus / Q000209:etiology; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000628:therapy
D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone