Muscle NMDA receptors regulate the resting membrane potential through NO-synthase.
The early postdenervation depolarization of rat diaphragm muscle fibres (8-10 mV) is substantially smaller (3 mV) when muscle strips are bathed with 1 mM L-glutamate (GLU) or N-methyl-D-aspartate (NMDA). The effects of GLU and NMDA are not seen in the presence of aminophosphonovaleric acid (APV), a blocker of NMDA-subtype of glutamate receptors, 5 mM Mg2+ (which blocks NMDA-controlled ion channels) and L-nitroarginine methylester (NAME), an inhibitor of NO-synthase. This indicates that NMDA-subtype of GLU receptors might be involved in the regulation of the membrane potential in muscle fibres, most probably through the NO-synthase system.
Urazaev
A K
AK
Kazan Medical University, Russia.
Magsumov
S T
ST
Poletayev
G I
GI
Nikolsky
E E
EE
Vyskocil
F
F
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000818:Animals; D003964:Diaphragm / Q000502:physiology; D018698:Glutamic Acid / Q000494:pharmacology; D008297:Male; D008564:Membrane Potentials / Q000502:physiology; D009121:Muscle Denervation; D009132:Muscles / Q000294:innervation / Q000378:metabolism* / Q000502:physiology*; D016202:N-Methylaspartate / Q000494:pharmacology; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology*
D016194:Receptors, N-Methyl-D-Aspartate; D018698:Glutamic Acid; D016202:N-Methylaspartate; D015763:2-Amino-5-phosphonovalerate; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester