title: Cytomegalovirus causing necrotizing laryngitis in a renal and cardiac transplant recipient.
abstract: BACKGROUND
  Cytomegalovirus (CMV) infection is a common opportunistic pathogen in transplant recipients; however, cytomegaloviral laryngitis is extremely rare.
  
  
  METHODS
  We present a case of disseminated CMV infection and ulcerating necrotizing laryngitis situated in the subglottis of an immunocompromised patient with a renal and cardiac transplant. The patient was initially seen with discomfort in the throat.
  
  
  RESULTS
  Physical examination of the head and neck, fiberoptic laryngoscopy, and CT scan of the larynx were normal. Histopathology of a laryngeal ulcer in the subglottic region showed intranuclear and intracytoplasmic bodies. Immunoperoxidase stain and in situ hybridization studies were positive for CMV.
  
  
  CONCLUSIONS
  In immunosuppressed patients with persistent throat symptoms, the systematic exploration of larynx and bronchus is necessary to rule out the presence of opportunistic infections.
authors.affiliation: Department of Otolaryngology, Hospital Juan Canalejo, Le Coruña, Spain.
authors.forename: M
authors.initials: M
authors.lastname: López-Amado
authors.forename: M T
authors.initials: MT
authors.lastname: Yebra-Pimentel
authors.forename: A
authors.initials: A
authors.lastname: García-Sarandeses
mesh_terms: D000328:Adult; D003586:Cytomegalovirus Infections / Q000150:complications*; D017809:Fatal Outcome; D016027:Heart Transplantation; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016030:Kidney Transplantation; D007827:Laryngitis / Q000821:virology*; D008297:Male; D009894:Opportunistic Infections / Q000821:virology