title: [Contrast media for magnetic resonance tomographic lymph node diagnosis (MR lymphography)].
abstract: In MR-imaging, similar to computed tomography, diagnosis of metastatic lymph-node disease is based on lymph-node sizes, and thereby it is non-specific. Super-paramagnetic iron oxide as a potential contrast medium for MR-lymphography accumulate in normal lymph node tissue after endolymphatic, interstitial and, in case of very small particles, after intravenous injection. No accumulation occures in lymph node metastases. Lymph-node metastases can be detected by all three injection techniques. It has been shown experimentally, that in particular small metastases can be detected in normal sized lymph nodes. However, MR-lymphography also has inherent methodologic problems, as there may occure an uneven distribution of the contrast medium between different lymph-node groups. The experimental results with endolymphatic, interstitial, and intravenous MR-lymphography as well as first clinical results with intravenous contrast medium injection are presented and discussed.
authors.affiliation: Institut für Röntgendiagnostik, Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin.
authors.forename: M
authors.initials: M
authors.lastname: Taupitz
authors.forename: S
authors.initials: S
authors.lastname: Wagner
authors.forename: B
authors.initials: B
authors.lastname: Hamm
mesh_terms: D003287:Contrast Media / Q000008:administration & dosage*; D005290:Ferric Compounds; D006801:Humans; D007089:Image Enhancement; D007275:Injections, Intravenous; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; C000499:ferric oxide