title: Extramedullary haematopoiesis in thalassaemia: results of radiotherapy: a report of three patients.
abstract: Extramedullary haematopoiesis is sometimes encountered in severe anaemia. Rarely, it may cause neurological symptoms, leading to spinal cord or cauda equina compression. Three patients with thalassaemia intermedia, who developed neurological complications, are described. The diagnoses were based on the clinical findings, computed tomography and magnetic resonance imaging. Small doses of radiotherapy (10-20 Gy in 5-10 fractions) relieved symptoms in all of these patients. Our experience supports the role of radiation therapy as a treatment for this complication.
authors.affiliation: Theagenion Cancer Center, Thessaloniki, Greece.
authors.forename: K
authors.initials: K
authors.lastname: Pistevou-Gompaki
authors.forename: G
authors.initials: G
authors.lastname: Skaragas
authors.forename: P
authors.initials: P
authors.lastname: Paraskevopoulos
authors.forename: K
authors.initials: K
authors.lastname: Kotsa
authors.forename: E
authors.initials: E
authors.lastname: Repanta
mesh_terms: D000328:Adult; D002420:Cauda Equina; D005500:Follow-Up Studies; D006411:Hematopoiesis, Extramedullary / Q000502:physiology* / Q000528:radiation effects; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009408:Nerve Compression Syndromes / Q000209:etiology / Q000532:radiotherapy; D011879:Radiotherapy Dosage; D013117:Spinal Cord Compression / Q000209:etiology / Q000532:radiotherapy*; D014057:Tomography, X-Ray Computed; D017086:beta-Thalassemia / Q000503:physiopathology*