title: Thymoma and agranulocytosis: two case reports and literature review.
abstract: Thymoma with agranulocytosis is a rare association. We describe two cases of agranulocytosis presenting with sepsis which were both found to have coincident benign spindle cell thymomas. One case, associated with promyelocyte arrest and hypogammaglobulinaemia, was treated successfully with granulocyte colony-stimulating factor (G-CSF). Thymectomy had no effect. The other case, associated with complete myeloid aplasia, proceeded to a fatal outcome after failure of treatment with granulocyte-macrophage colony stimulating factor (GM-CSF), plasmapheresis, thymectomy, intravenous immunoglobulin, cyclophosphamide and methylprednisolone. We also review the literature of thymoma in association with agranulocytosis.
authors.affiliation: Department of Haematology, Westmead Hospital, Australia.
authors.forename: D
authors.initials: D
authors.lastname: Yip
authors.forename: J E
authors.initials: JE
authors.lastname: Rasko
authors.forename: C
authors.initials: C
authors.lastname: Lee
authors.forename: H
authors.initials: H
authors.lastname: Kronenberg
authors.forename: B
authors.initials: B
authors.lastname: O'Neill
mesh_terms: D000380:Agranulocytosis / Q000150:complications* / Q000473:pathology / Q000628:therapy; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D013945:Thymoma / Q000150:complications* / Q000473:pathology / Q000628:therapy; D013953:Thymus Neoplasms / Q000150:complications* / Q000473:pathology / Q000628:therapy
chemical_list: D016179:Granulocyte Colony-Stimulating Factor