An evaluation of the WHO criteria for abnormal glucose tolerance test during pregnancy in Nigerian women.
A 75 g oral glucose tolerance test was performed in 127 normal Nigerian women between 24 and 28 weeks of pregnancy. The glucose response at fasting, 1, 2 and 3 h were studied. At 2 h, the glucose level at 2-SD and 4-SD above the mean were less than the criteria of abnormality recommended by the World Health Organisation: 6.5 mmol/l vs. 8 mmol/l for impaired glucose tolerance and 8.0 mmol/l vs. 11.0 mmol/l for gestational diabetes mellitus. The area under the glucose response curve correlated best with the glucose levels at 2 h during the OGTT (y = 4.3 + 1.8x, r = 0.862). The 75-g OGTT interpreted with the WHO criteria appear not to be appropriate for use in pregnant women in Nigeria.
Okonofua
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FE
Department of Obstetrics, Gynaecology and Perinatology, Obafemi Awolowo University, Ile-Ife, Nigeria.
Onwudiegwu
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U
Ugwu
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NC
D000328:Adult; D044383:Black People; D016640:Diabetes, Gestational / Q000097:blood / Q000175:diagnosis*; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000175:diagnosis*; D005951:Glucose Tolerance Test / Q000592:standards*; D006801:Humans; D016014:Linear Models; D009549:Nigeria; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000175:diagnosis*; D015203:Reproducibility of Results; D014944:World Health Organization