title: Laboratory of Caribbean Brain Research Organization in the decade of the brain midpoint. Results in reaching behavior--interferences of subcortical motor centers, neurotransmitter blocking and brain function modeling.
abstract: CARIBRO was founded in response to the United Nations declaration that the 1990s be designated the Decade of the Brain. The Program of Action is: 1. Annual meetings; 2. Training courses of the Caribbean School of Neurosciences; 3. Network scientific programs; 4. Fellowship programs; and 5. Dissemination of information on neuroscience. In the same program, a CARIBRO Laboratory was created in one of the Medical Faculties of Havana with the aim to teach students from the Caribbean in neuroscience research. As part of this program, we have been working in lateralized motor functions. Preliminary results in rats show that reaching acquisition allows classification of the animals as right-handed (40%), left-handed (40%), and ambidextrous (20%). Electrolytic lesion of caudate nucleus or amygdala impairs lateralized response. Contralateral lesions increase reaching attempts. Ipsilateral lesions to the preferred forepaw do not affect the reaction. The results remain the same 10, 20, and 90 d after the interference. Pharmacological experiments showed that trihexiphenidil (0.1 mg/kg i.p.) induced handedness reversion in 50% if the animals, whereas haloperidol (1 mg/kg i.p.) produced immobility, tremor, and autonomic symptoms. This effect remained the same in young as well as in old animals. We are also working on mathematical modelation. In this sense, preliminary reports about a model for synaptic modification in the framework of the Fukushima hypothesis is discussed.
authors.affiliation: Laboratory of Caribbean Brain Research Organization (CARIBRO), ICBP V. Girón, ISCM-H, Havana, Cuba.
authors.forename: N
authors.initials: N
authors.lastname: Hernández-Mesa
authors.forename: M
authors.initials: M
authors.lastname: Antón
authors.forename: M
authors.initials: M
authors.lastname: Arza-Marqués
authors.forename: R
authors.initials: R
authors.lastname: Aneiros-Riba
authors.forename: E
authors.initials: E
authors.lastname: Groning-Roque
mesh_terms: D000818:Animals; D001519:Behavior; D001522:Behavior, Animal; D001921:Brain / Q000502:physiology*; D017691:Caribbean Region; D003462:Cuba; D005257:Fellowships and Scholarships; D006801:Humans; D009488:Neurosciences; D009938:Organizations; D051381:Rats; D012106:Research