title: Different rifampicin inactivation mechanisms in Nocardia and related taxa.
abstract: Mycolic acid-containing bacteria inactivate rifampicin in a variety of ways such as glucosylation, ribosylation, phosphorylation and decolorization. These inactivations were found to be a species-specific phenomena in Nocardia and related taxa. Gordona, Tsukamurella and fast-growing Mycobacterium modified rifampicin by ribosylation of the 23-OH group of the antibiotic. Such ribosylation was not observed in Rhodococcus and Corynebacterium, but phosphorylation of the 21-OH group of rifampicin was observed in one strain of Rhodococcus. Nocardia modified the antibiotic by glucosylation (23-OH group) and phosphorylation, but ribosylation was not observed.
authors.affiliation: Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Yazawa
authors.forename: E R
authors.initials: ER
authors.lastname: Dabbs
authors.forename: K
authors.initials: K
authors.lastname: Nishikawa
authors.forename: H
authors.initials: H
authors.lastname: Komaki
authors.forename: Y
authors.initials: Y
authors.lastname: Mikami
authors.forename: M
authors.initials: M
authors.lastname: Miyaji
authors.forename: N
authors.initials: N
authors.lastname: Morisaki
authors.forename: S
authors.initials: S
authors.lastname: Iwasaki
mesh_terms: D000192:Actinomycetales / Q000187:drug effects* / Q000378:metabolism; D004352:Drug Resistance, Microbial; D006031:Glycosylation; D008826:Microbial Sensitivity Tests; D010766:Phosphorylation; D012293:Rifampin / Q000737:chemistry / Q000494:pharmacology*; D013045:Species Specificity
chemical_list: D012293:Rifampin