DNA immunization.
Inoculation with plasmid DNA vectors encoding immunogenic proteins induces both humoral and cell-mediated immune responses, which often provide protective immunity. Although many questions regarding the mechanism, efficacy and safety of DNA immunization remain to be addressed, this approach may offer a safer and more cost-effective alternative to conventional vaccines.
Hassett
D E
DE
Dept of Neuropharmacology, Scripps Research Insitute, La Jolla, CA 92037, USA.
Whitton
J L
JL
D000818:Animals; D003140:Communicable Disease Control / Q000379:methods; D003141:Communicable Diseases / Q000276:immunology; D004333:Drug Administration Routes; D015195:Drug Design; D005822:Genetic Vectors; D007114:Immunization / Q000009:adverse effects / Q000379:methods*; D051379:Mice; D019444:Vaccines, DNA / Q000276:immunology*
D019444:Vaccines, DNA