title: Biochemical and biomolecular aspects of oxidative stress due to acute and severe hypoxia in human muscle tissue.
abstract: Mitochondrial oxidative stress was investigated in severe and acute hypoxia and in reperfusion applied to human muscle tissues. The biochemical and biomolecular relationship between the response of the respiratory-chain enzymic complexes and the metabolism of specific hypoxia stress proteins (HSP) suggest an adaptive mechanism which antagonizes the oxidative damage due to acute and severe tissue hypoxia.
authors.affiliation: Institute of Anaesthesia and Resuscitation, University of Cagliari, Italy.
authors.forename: G G
authors.initials: GG
authors.lastname: Corbucci
authors.forename: R
authors.initials: R
authors.lastname: Sessego
authors.forename: C
authors.initials: C
authors.lastname: Velluti
authors.forename: M
authors.initials: M
authors.lastname: Salvi
mesh_terms: D000208:Acute Disease; D000222:Adaptation, Physiological; D003593:Cytoplasm / Q000201:enzymology; D003576:Electron Transport Complex IV / Q000378:metabolism; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D000860:Hypoxia / Q000378:metabolism*; D008931:Mitochondria, Muscle / Q000201:enzymology; D009132:Muscles / Q000378:metabolism*; D018384:Oxidative Stress; D013385:Succinate Dehydrogenase / Q000378:metabolism
chemical_list: D018840:HSP70 Heat-Shock Proteins; D013385:Succinate Dehydrogenase; D003576:Electron Transport Complex IV