title: Acute generalized exanthematous pustulosis induced by dexamethasone injection.
abstract: A 52-year-old woman, without a history of psoriasis, developed a widespread, sterile pustular eruption on the trunk and extremities 2 days after subcutaneous injection of dexamethasone solution. Skin biopsy revealed subcorneal pustules filled with neutrophils and moderate lymphohistiocytic infiltrate with a few eosinophils in the dermis. There was no evidence of vasculitis. Patch testing showed positive pustular reactions to dexamethasone solution. Histology of this pustule also resembled that of the original eruption. To our knowledge, acute generalized exanthematous pustulosis due to corticosteroid has not been previously reported.
authors.affiliation: Department of Dermatology, Jichi Medical School, Tochigi-ken, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Demitsu
authors.forename: A
authors.initials: A
authors.lastname: Kosuge
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: K
authors.initials: K
authors.lastname: Usui
authors.forename: H
authors.initials: H
authors.lastname: Katayama
authors.forename: H
authors.initials: H
authors.lastname: Yaoita
mesh_terms: D000208:Acute Disease; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D007592:Joint Diseases / Q000188:drug therapy; D008875:Middle Aged; D017444:Skin Diseases, Papulosquamous / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D003907:Dexamethasone