title: The effect of budesonide (Rhinocort) in the treatment of small and medium-sized nasal polyps.
abstract: The objectives of this study were to determine if the size of nasal polyps could be assessed in a reproducible way and to study the effect of budesonide in patients suffering from eosinophilic nasal polyposis with small and medium sized polyps. Ninety-one patients entered the study. Budesonide 200 micrograms b.i.d. (aerosol or aqua) and placebo (aerosol or aqua) were compared in a 3-month double-blind, multi-centre, randomized study. Efficacy was measured by an assessment of polyp size, nasal peak-flow index and the patient's assessment of nasal symptoms. The conclusions were that the size of polyps could be assessed in a reproducible way, and that budesonide delivered either as a water-based suspension or as an aerosol is effective in the treatment of patients with small and medium sized polyps.
authors.affiliation: Department of ORL, University Hospital of Aarhus, Denmark.
authors.forename: L
authors.initials: L
authors.lastname: Vendelo Johansen
authors.forename: P
authors.initials: P
authors.lastname: Illum
authors.forename: S
authors.initials: S
authors.lastname: Kristensen
authors.forename: L
authors.initials: L
authors.lastname: Winther
authors.forename: S
authors.initials: S
authors.lastname: Vang Petersen
authors.forename: B
authors.initials: B
authors.lastname: Synnerstad
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D019819:Budesonide; D004311:Double-Blind Method; D005938:Glucocorticoids; D006801:Humans; D008875:Middle Aged; D009298:Nasal Polyps / Q000188:drug therapy*; D010919:Placebos; D011282:Pregnenediones / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000336:Aerosols; D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D010919:Placebos; D011282:Pregnenediones; D019819:Budesonide