title: Relationship of ovarian stromal blood flow at the baseline ultrasound scan to subsequent follicular response in an in vitro fertilization program.
abstract: OBJECTIVE
  To assess whether Doppler indices of intraovarian blood flow are related to the subsequent follicular response in an in vitro fertilization (IVF) program.
  
  
  METHODS
  One hundred five women underwent ultrasonographic assessment of ovarian morphology, transvaginal color Doppler measurement of intraovarian blood flow and immunoassay of serum FSH during the early follicular phase of an IVF cycle. The subsequent follicular response was related to the Doppler data.
  
  
  RESULTS
  Mean ovarian stromal peak systolic blood flow velocity was significantly correlated with the follicular response (P = .001), even after adjusting for the age of patient, type of ovary (polycystic or normal), total number of human menopausal gonadotropin ampules used, and serum FSH. Mean ovarian stromal pulsatility index was not related to the follicular response. Mean ovarian stromal peak systolic blood flow velocity was significantly lower (P = .007) in the poor-response group. The adjusted odds of a poor response increased significantly by an estimated 22% per cm/second decrease in velocity (P = .02).
  
  
  CONCLUSIONS
  Ovarian stromal blood flow at the baseline ultrasound scan is correlated with subsequent follicular response and may be a new indicator for predicting ovarian responsiveness in an IVF program.
authors.affiliation: London Women's Clinic, United Kingdom.
authors.forename: J
authors.initials: J
authors.lastname: Zaidi
authors.forename: J
authors.initials: J
authors.lastname: Barber
authors.forename: A
authors.initials: A
authors.lastname: Kyei-Mensah
authors.forename: J
authors.initials: J
authors.lastname: Bekir
authors.forename: S
authors.initials: S
authors.lastname: Campbell
authors.forename: S L
authors.initials: SL
authors.lastname: Tan
mesh_terms: D000328:Adult; D002064:Buserelin / Q000494:pharmacology; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006062:Gonadotropins / Q000494:pharmacology; D006801:Humans; D016015:Logistic Models; D006080:Ovarian Follicle / Q000502:physiology*; D010053:Ovary / Q000098:blood supply* / Q000000981:diagnostic imaging*; D011379:Prognosis; D011446:Prospective Studies; D012039:Regional Blood Flow; D016896:Treatment Outcome; D018608:Ultrasonography, Doppler
chemical_list: D006062:Gonadotropins; D005640:Follicle Stimulating Hormone; D002064:Buserelin