Role of c-mos proto-oncogene product in the regulation of mouse oocyte maturation.
The c-mos proto-oncogene product (Mos) is essential for the initiation of oocyte maturation, for the suppression of DNA synthesis during meiosis, and for the second metaphase arrest in Xenopus. To clarify the function of Mos in mice, c-mos-deficient mice were generated by gene targeting. We cultured oocytes from c-mos-deficient females to determine the role of Mos in oocyte maturation. c-mos-deficient oocytes matured normally to the second metaphase, but were activated without fertilization. Thus, prevention of parthenogenetic activation might be an ultimate biological function of Mos in animal oocytes.
Hashimoto
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Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
D000818:Animals; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D008540:Meiosis; D008677:Metaphase; D051379:Mice; D018345:Mice, Knockout; D009865:Oocytes / Q000166:cytology / Q000254:growth & development*; D017231:Proto-Oncogene Proteins c-mos / Q000502:physiology*
D004247:DNA; D017231:Proto-Oncogene Proteins c-mos