[Effect of enomelanin on lipid peroxidation and the glutathione system in rat lung tissue exposed to NO2].
Effect of preliminary intraperitoneal injection on the state of the glutathione system and lipid peroxidation intensity in the lungs of rats subjected to NO2 has been studient. This compound is shown to decrease significantly all lipid peroxidation processes and to inhibit completely glutathion oxidation. These effects are supposed to be a result not only of antioxidant properties of enomelanin, but also of its ability to promote a decrease in the activity of glutathione-depending enzymes subjected to NO2.
Galkin
B N
BN
Golovenko
N Ia
NIa
Barinov
V A
VA
Tiunov
L A
LA
Osetrov
V E
VE
Filippova
T O
TO
Barinova
I E
IE
Savva
V M
VM
D000818:Animals; D005978:Glutathione / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D015227:Lipid Peroxidation / Q000187:drug effects*; D008168:Lung / Q000378:metabolism*; D008297:Male; D008543:Melanins / Q000008:administration & dosage / Q000494:pharmacology*; D009569:Nitric Oxide / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D008543:Melanins; C049066:enomelanin; D009569:Nitric Oxide; D005978:Glutathione