title: Carbamazepine inhibits the potentiation by adenosine analogues of agonist induced inositolphosphate formation in hippocampal astrocyte cultures.
abstract: Carbamazepine (CBZ) resembles lithium in its beneficial effects in therapy and prophylaxis of affective disorders. Since lithium is presumed to act via an attenuation of the inositolphosphate/Ca(2+)-second messenger system, it is of particular interest whether or not CBZ might also have inhibitory effects on this type of signal transduction. CBZ is an antagonist of adenosine A1-receptor subtypes. We show here that activation of adenosine A1-receptors potentiates the phenylephrine induced formation of inositolphosphates in hippocampal astrocytes and that this potentiating effect is inhibited by CBZ at a therapeutically relevant concentration. These results indicate that CBZ can by antagonism of adenosine A1-receptors inhibit the inositolphosphate/Ca(2+)-signalling in neural pathways regulated by adenosine.
authors.affiliation: Department of Psychiatry, University of Freiburg, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Biber
authors.forename: J
authors.initials: J
authors.lastname: Walden
authors.forename: P
authors.initials: P
authors.lastname: Gebicke-Härter
authors.forename: M
authors.initials: M
authors.lastname: Berger
authors.forename: D
authors.initials: D
authors.lastname: van Calker
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D001253:Astrocytes / Q000187:drug effects*; D002220:Carbamazepine / Q000494:pharmacology*; D002478:Cells, Cultured; D004357:Drug Synergism; D006624:Hippocampus / Q000187:drug effects*; D007295:Inositol Phosphates / Q000378:metabolism*; D018021:Lithium Chloride / Q000494:pharmacology; D009434:Neural Pathways / Q000187:drug effects; D010656:Phenylephrine / Q000494:pharmacology; D058915:Purinergic P1 Receptor Antagonists; D051381:Rats; D018047:Receptors, Purinergic P1 / Q000145:classification; D015290:Second Messenger Systems / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D007295:Inositol Phosphates; D058915:Purinergic P1 Receptor Antagonists; D018047:Receptors, Purinergic P1; D010656:Phenylephrine; C045537:inositol 4-phosphate; D002220:Carbamazepine; D018021:Lithium Chloride; D000241:Adenosine