title: Issues in clinical trial design I: Use of natural history controls. A protagonist view.
authors.affiliation: Department of Neurology, New England Medical Center, Boston, MA 02111, USA.
authors.forename: T L
authors.initials: TL
authors.lastname: Munsat
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000503:physiopathology*; D002986:Clinical Trials as Topic; D006801:Humans