Characteristics of airway eosinophils.
Eosinophils are important participants and contributors to allergic inflammation in asthma. The mechanisms by which eosinophils migrate to the airway and are activated are not clear. Moreover, there is evidence that eosinophils from the airway are functionally distinct from those cells in circulation. In initial studies, we have found distinct differences in function, cell surface markers, calcium metabolism in response to activation, and survival in eosinophils from the airway. In an attempt to ascertain what factors regulate these phenotypic changes, we have evaluated the effect of cytokines and adhesion on eosinophil function.
Busse
W W
WW
University of Wisconsin Medical School, Madison, USA.
Nagata
M
M
Sedgwick
J B
JB
D001249:Asthma / Q000097:blood / Q000276:immunology*; D001980:Bronchi / Q000166:cytology* / Q000276:immunology*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D018845:CD11 Antigens / Q000096:biosynthesis; D018821:CD18 Antigens / Q000096:biosynthesis; D002448:Cell Adhesion / Q000276:immunology / Q000502:physiology; D002478:Cells, Cultured; D004804:Eosinophils / Q000276:immunology* / Q000502:physiology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D006684:HLA-DR Antigens / Q000096:biosynthesis; D006801:Humans; D017463:Receptors, Complement 3b / Q000096:biosynthesis; D019010:Vascular Cell Adhesion Molecule-1 / Q000502:physiology
D018845:CD11 Antigens; D018821:CD18 Antigens; D006684:HLA-DR Antigens; D017463:Receptors, Complement 3b; D019010:Vascular Cell Adhesion Molecule-1; D016178:Granulocyte-Macrophage Colony-Stimulating Factor