title: Gestational choriocarcinoma metastatic to the brain treated successfully by stereotactic radiosurgery and chemotherapy.
abstract: Metastatic gestational choriocarcinoma not uncommonly affects the central nervous system. If possible, the initial management of these metastases is surgical excision prior to chemotherapy, since these lesions are haemorrhagic. We report a patient with choriocarcinoma metastatic to the brain in whom surgery was potentially hazardous. Treatment was successfully given with stereotactic radiosurgery followed by chemotherapy.
authors.affiliation: Charing Cross Hospital, London, UK.
authors.forename: M D
authors.initials: MD
authors.lastname: Leslie
authors.forename: G
authors.initials: G
authors.lastname: Mangili
authors.forename: A A
authors.initials: AA
authors.lastname: Kemeny
authors.forename: E S
authors.initials: ES
authors.lastname: Newlands
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000556:secondary* / Q000601:surgery*; D002822:Choriocarcinoma / Q000473:pathology*; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D003609:Dactinomycin / Q000627:therapeutic use; D005047:Etoposide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy* / Q000601:surgery*; D016634:Radiosurgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000473:pathology*; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D003609:Dactinomycin; D014750:Vincristine; D005047:Etoposide; D003520:Cyclophosphamide; D008727:Methotrexate