Low serum interleukin-10 levels in multiple sclerosis: further evidence for decreased systemic immunosuppression?
Serum interleukin 10 (IL10) levels were assessed in patients with multiple sclerosis who were either in a stable or active clinical condition. The levels were compared with values in healthy controls. Lower IL10 levels than in controls were seen in multiple sclerosis patients, regardless of clinical disease activity. Low IL10 levels were also seen in patients with systemic lupus erythematosus. No clear-cut relationships emerged between IL10 levels and those of tumour necrosis factor alpha and transforming growth factor beta, or between IL10 and lymphocyte subsets in peripheral blood.
Salmaggi
A
A
Istituto Nazionale Neurologico C. Besta, Milano, Italy.
Dufour
A
A
Eoli
M
M
Corsini
E
E
La Mantia
L
L
Massa
G
G
Nespolo
A
A
Milanese
C
C
D000328:Adult; D000368:Aged; D015704:CD4 Antigens / Q000032:analysis; D005260:Female; D006801:Humans; D007107:Immune System / Q000503:physiopathology*; D016753:Interleukin-10 / Q000097:blood*; D017493:Leukocyte Common Antigens / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000097:blood; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood*; D012016:Reference Values
D015704:CD4 Antigens; D016753:Interleukin-10; D017493:Leukocyte Common Antigens