Metabolites from an Antarctic sponge-associated bacterium, Pseudomonas aeruginosa.
In an ongoing survey of the bioactive potential of microorganisms associated with marine invertebrates, the culture media of a sponge-associated bacterial strain of Pseudomonas aeruginosa was found to contain metabolites which inhibit the growth of several Gram-positive microorganisms. A series of diketopiperazines (1-6) including a new natural product (6) and two known phenazine alkaloid antibiotics (7 and 8) were isolated from the culture broth of this bacterium.
Jayatilake
G S
GS
Department of Chemistry, Florida Institute of Technology, Melbourne 32901, USA.
Thornton
M P
MP
Leonard
A C
AC
Grimwade
J E
JE
Baker
B J
BJ
D000470:Alkaloids / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000864:Antarctic Regions; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D003470:Culture Media; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010879:Piperazines / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D011161:Porifera / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification / Q000378:metabolism*; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D003470:Culture Media; D010879:Piperazines