Effects of apo B and apo E gene polymorphisms on lipid and apolipoprotein concentrations after a test meal.
The role of apo B signal peptide and apo E polymorphisms, and individual factors (age, sex, etc.) have been investigated on the interindividual variability of the postprandial response of 274 subjects ingesting a 1.260-KJ milkshake. The mean postprandial response, observed during 4 h, is significantly positive for total cholesterol (P < 0.005), LDL-cholesterol (P < 0.0001), triglycerides (P < 0.001), apo E (P < 0.0001) and glucose (P < 0.0001), whereas HDL-cholesterol, apo A-I and apo B do not present mean postprandial variation. Independently of the mean response, some parameters present a large interindividual variability of response, which is significantly influenced by cofactors, such as weight or BMI, for total and LDL-cholesterol, apo B and apo E or tobacco use for HDL-cholesterol. Sex has no effect on any lipid levels. Total, LDL-cholesterol and apo E responses are correlated with their corresponding fasting values. ApoB signal peptide polymorphism is not involved in the postprandial responses, whereas apo E polymorphism explains a significant part of the variability of HDL-cholesterol and apo A-I responses.
Regis-Bailly
A
A
Centre de Médecine Préventive, UA CNRS 597, Vandoeuvre-Les-Nancy, France.
Visvikis
S
S
Steinmetz
J
J
Fournier
B
B
Gueguen
R
R
Siest
G
G
D000328:Adult; D000367:Age Factors; D001053:Apolipoproteins / Q000097:blood*; D001055:Apolipoproteins B / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D002784:Cholesterol / Q000097:blood; D004435:Eating / Q000502:physiology; D005260:Female; D005502:Food; D006801:Humans; D007206:Individuality; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D021382:Protein Sorting Signals / Q000502:physiology; D012737:Sex Factors
D001053:Apolipoproteins; D001055:Apolipoproteins B; D001057:Apolipoproteins E; D008055:Lipids; D021382:Protein Sorting Signals; D002784:Cholesterol