title: Rhegmatogenous retinal detachments in HIV-positive patients with ocular syphilis.
abstract: The purpose of this study is to report retinal manifestations of lues in human immunodeficiency virus (HIV)-positive patients and to suggest a method for treatment of rhegmatogenous retinal detachments in these patients. Two HIV-positive patients with bilateral retinitis were examined and treated at the authors' institution for a period of 14 months. Ocular syphilis was diagnosed clinically, confirmed by cerebrospinal fluid serologic testing, and treated with intravenous penicillin. Both patients experienced bilateral rhegmatogenous retinal detachments complicated by proliferative vitreoretinopathy after resolution of the active retinitis. All four eyes underwent surgical repair with trans pars plana vitrectomy, epiretinal membrane delamination, gas-fluid exchange, endolaser, scleral buckle, and silicone oil instillation. The recognition of ocular syphilis as a cause of retinal detachment in HIV-positive patients is important. Prompt intervention with the appropriate medical and surgical treatments may result in the preservation of vision in these patients.
authors.affiliation: Department of Ophthalmology, University of California at San Diego, La Jolla 92093-0946, USA.
authors.forename: J K
authors.initials: JK
authors.lastname: Williams
authors.forename: L S
authors.initials: LS
authors.lastname: Kirsch
authors.forename: V
authors.initials: V
authors.lastname: Russack
authors.forename: W R
authors.initials: WR
authors.lastname: Freeman
mesh_terms: D000328:Adult; D015818:Eye Infections, Bacterial / Q000150:complications* / Q000188:drug therapy; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006679:HIV Seropositivity / Q000150:complications*; D015497:HIV-1; D006801:Humans; D008297:Male; D010400:Penicillin G / Q000627:therapeutic use; D010406:Penicillins / Q000627:therapeutic use; D012163:Retinal Detachment / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D012173:Retinitis / Q000188:drug therapy / Q000382:microbiology*; D013587:Syphilis / Q000150:complications* / Q000188:drug therapy; D013588:Syphilis Serodiagnosis; D014792:Visual Acuity; D018630:Vitreoretinopathy, Proliferative / Q000209:etiology / Q000601:surgery
chemical_list: D010406:Penicillins; D010400:Penicillin G