Elevated endothelin-1 levels and persistent stage IV hypertension in a nonvolume overloaded anephric patient.
Persistent hypertension after nephrectomy is in most cases due to increased fluid volume. Endothelin-1 is a potent endogenous vasoconstrictor peptide. Its role in the development and maintenance of hypertension is not completely understood, but it might be significant in some cases. We report a case of stage IV hypertension after nephrectomy with elevated endothelin-1 levels and no volume overload.
Vajo
Z
Z
Department of Medicine, Maricopa Medical Center, Phoenix, Arizona 85008, USA.
Moffitt
R A
RA
Parvathala
S
S
Szekacs
B
B
Dachman
W D
WD
D000328:Adult; D001794:Blood Pressure; D019332:Endothelin-1 / Q000097:blood*; D004921:Erythropoietin / Q000009:adverse effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis*; D009392:Nephrectomy; D006435:Renal Dialysis / Q000009:adverse effects
D019332:Endothelin-1; D004921:Erythropoietin