Unusual split chimaerism after mismatched T-depleted BMT.
We report a case of haploidentical T-depleted BMT that engrafted durably after a highly immunosuppressive conditioning regimen. DNA polymorphism analysis showed that granulocytes and monocytes were donor type but T and B lymphocytes were host derived. Host tolerance to donor antigens was documented. The patient suffered from serious recurrent CMV infections until split chimaerism shifted to full donor type 2 years post-BMT. Seven years after BMT the patient remains in complete remission.
Terenzi
A
A
Haematology and Clinical Immunology, University of Perugia, Italy.
Aversa
F
F
Mencarelli
A
A
Pelicci
P
P
Velardi
A
A
Perruccio
K
K
Martelli
M F
MF
D000328:Adult; D016026:Bone Marrow Transplantation; D002678:Chimera; D004247:DNA / Q000032:analysis; D006650:Histocompatibility Testing; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008212:Lymphocyte Depletion; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*
D004247:DNA