Thymic carcinoma of the thyroid.
A highly malignant case of intrathyroidal thymic carcinoma showing morphological and biochemical evidence identical with mediastinal thymoma is presented. A 32-year-old female, who had previously undergone total colectomy with ileo-proctostomy due to familial adenomatous polypnosis, was operated on for a tumor (3.4 x 4.5 cm) originating from the left thyroid lobe. A minute focus (diam. 0.8 cm) of papillary adenocarcinoma also existed in the upper pole of the right lobe. The main tumor was morphologically an epithelial thymoma with scanty lymphocyte intermixing and showed medullary differentiation with apparent Hassall's corpuscles. Mitosis was frequent and numerous tumor thrombi were in the subcapsular veins. Five months after the total thyroidectomy and lymph node dissection, a subcutaneous recurrence of the tumour (diam. 2.3 cm) appeared in the anterior cervical region. The cystic contents of the recurrent tumor revealed a high titer of thymosin alpha 1-Other organs, including thymus, lungs, and adrenals, had all been free of neoplastic changes clinically and radiologically for 5 months after her first admission until the local tumor recurrence.
Watanabe
I
I
Division of Surgery, Tohoku Teishin Hospital, Sendai, Japan.
Tezuka
F
F
Yamaguchi
M
M
Sagawa
J
J
Kaise
N
N
D000328:Adult; D002454:Cell Differentiation / Q000502:physiology; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D009363:Neoplasm Proteins / Q000032:analysis; D000077596:Thymalfasin; D013945:Thymoma / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D013947:Thymosin / Q000031:analogs & derivatives / Q000032:analysis; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure
D009363:Neoplasm Proteins; D013947:Thymosin; D000077596:Thymalfasin