Comparable amyloid beta-protein (A beta) 42(43) and A beta 40 deposition in the aged monkey brain.
Two distinct species of amyloid beta-protein (A beta), A beta 42(43) and A beta 40, are deposited in the brains of patients with Alzheimer's disease and normal aged individuals. A beta 42(43), the long tailed A beta, is the initially and predominantly deposited species in senile plaques. Deposition of A beta is also observed in the aged monkey brains. We investigated the A beta species in the aged monkey brains immunocytochemically using monoclonal antibodies that discriminate between the C-termini of A beta 42(43) and A beta 40. We report here that A beta 40 as well as A beta 42(43) deposit in various types of senile plaques, including diffuse plaques of the aged monkey brain and that the ratio of A beta 40 to A beta 42(43) is higher compared with that in human brain.
Kanemaru
K
K
Department of Neurology, Tokyo Metropolitan Geriatric Hospital, Japan.
Iwatsubo
T
T
Ihara
Y
Y
D000375:Aging / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D000911:Antibodies, Monoclonal; D001923:Brain Chemistry / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D008251:Macaca; D009410:Nerve Degeneration / Q000502:physiology
D016229:Amyloid beta-Peptides; D000911:Antibodies, Monoclonal