Attenuation of oxidation and nitration reactions of peroxynitrite by selenomethionine, selenocystine and ebselen.
The effect of the selenium-containing compounds selenomethionine, selenocystine and ebselen [2-phenyl-1,2-benzisoselenazol-3(2H)-one] on the oxidation of dihydrorhodamine 123 caused by peroxynitrite and on the nitration of 4-hydroxyphenylacetate by peroxynitrite was studied in comparison with their sulphur analogues methionine, cystine and ebsulfur [2-phenyl-1,2-benzisothiazol-3(2H)-one]. The selenocompounds protected dihydrorhodamine 123 from oxidation and 4-hydroxyphenylacetate from nitration more effectively than their sulphur analogues. Sodium selenite exhibited no effect. These observations are corollaries to the recent finding [Roussyn, Briviba, Masumoto and Sies (1996) Arch. Biochem. Biophys. 330, 216-218] that selenium-containing compounds are efficient in protecting against peroxynitrite-induced DNA single-strand breaks.
Briviba
K
K
Institut für Physiologische Chemie I, Heinrich-Heine-Universität Düsseldorf, Federal Republic of Germany.
Roussyn
I
I
Sharov
V S
VS
Sies
H
H
D001393:Azoles / Q000378:metabolism*; D003553:Cystine / Q000031:analogs & derivatives* / Q000378:metabolism; D054833:Isoindoles; D007700:Kinetics; D009566:Nitrates / Q000378:metabolism*; D016566:Organoselenium Compounds / Q000378:metabolism*; D010084:Oxidation-Reduction; D010648:Phenylacetates / Q000378:metabolism; D012235:Rhodamines / Q000378:metabolism; D012645:Selenomethionine / Q000378:metabolism*
D001393:Azoles; D054833:Isoindoles; D009566:Nitrates; D016566:Organoselenium Compounds; D010648:Phenylacetates; D012235:Rhodamines; C058319:dihydrorhodamine 123; C009226:selenocystine; C039642:peroxynitric acid; C026246:4-hydroxyphenylacetate; C042986:ebselen; D003553:Cystine; D012645:Selenomethionine