title: Unusual split chimaerism after mismatched T-depleted BMT.
abstract: We report a case of haploidentical T-depleted BMT that engrafted durably after a highly immunosuppressive conditioning regimen. DNA polymorphism analysis showed that granulocytes and monocytes were donor type but T and B lymphocytes were host derived. Host tolerance to donor antigens was documented. The patient suffered from serious recurrent CMV infections until split chimaerism shifted to full donor type 2 years post-BMT. Seven years after BMT the patient remains in complete remission.
authors.affiliation: Haematology and Clinical Immunology, University of Perugia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Terenzi
authors.forename: F
authors.initials: F
authors.lastname: Aversa
authors.forename: A
authors.initials: A
authors.lastname: Mencarelli
authors.forename: P
authors.initials: P
authors.lastname: Pelicci
authors.forename: A
authors.initials: A
authors.lastname: Velardi
authors.forename: K
authors.initials: K
authors.lastname: Perruccio
authors.forename: M F
authors.initials: MF
authors.lastname: Martelli
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D002678:Chimera; D004247:DNA / Q000032:analysis; D006650:Histocompatibility Testing; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008212:Lymphocyte Depletion; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D004247:DNA