Buflomedil poisoning: five cases with cardiotoxicity.
OBJECTIVE
To report cardiotoxicity of buflomedil.


METHODS
Medical intensive care unit of a university hospital.


METHODS
Five patients admitted to the hospital since 1985 for buflomedil poisoning. The amount ingested was known for only three patients (3-10.8 g).


RESULTS
The five young women were admitted to the hospital because of generalized seizures or myoclonic jerks. Cardiac arrest (asystole) occurred for two of them on admission, 1 and 3 h after ingestion. Electrocardiogram revealed atrio-ventricular and intraventricular conduction abnormalities, increased QT interval and flattened T wave, decreasing after sodium bicarbonate infusion in two cases. The patients received mechanical ventilation, gastric lavage, oral activated charcoal, and clonazepam or valproic acid for convulsions or myoclonic jerks. Epinephrine was administered for cardiac arrest. Sodium bicarbonate was infused in one patient on the basis of slightly prolonged QRS duration and in two patients due to cardiac arrest. Clinical outcome was good and without sequelae for all five patients after a few days in the intensive care unit.


CONCLUSIONS
Clinical and electrocardiographic symptomatology of buflomedil poisoning suggests direct cardiotoxicity, which could be related to possible sodium antagonist properties.
Legras
A
A
Medical Intensive Care Unit, Hopital Bretonneau, Tours, France.
Piquemal
R
R
Furet
Y
Y
Dequin
P F
PF
Perrotin
D
D
D000293:Adolescent; D000328:Adult; D003128:Coma; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000187:drug effects*; D006323:Heart Arrest / Q000209:etiology; D006801:Humans; D011759:Pyrrolidines / Q000494:pharmacology / Q000506:poisoning*; D012640:Seizures; D014665:Vasodilator Agents / Q000494:pharmacology / Q000506:poisoning*
D011759:Pyrrolidines; D014665:Vasodilator Agents; C010651:buflomedil