title: Hemispherectomy for intractable seizures in children: a report of 58 cases.
abstract: Fifty-eight children who underwent anatomical, functional, or modified anatomical hemispherectomy for intractable seizures from 1986 to 1995 were evaluated for seizure control, motor function, and complications. Age at surgery ranged from 0.3 to 17.3 years (median 2.8 years). Twenty-seven anatomical, 27 functional, and 4 modified anatomical hemispherectomies were performed. Seizure control and motor function in the 50 patients with more than 1 year follow-up revealed a 90% or better reduction in seizure frequency in 44/50 (88%) overall: 19/22 (86%) anatomical, 23/26 (89%) functional, and 2/2 modified anatomical. Motor function of the preoperatively hemiparetic extremities was improved or unchanged postoperatively in 38/50 (76%) of the patients. Complications included one intraoperative death, one late death from shunt obstruction managed elsewhere, late postoperative seizure breakthrough requiring reoperation and further disconnection in 5/27 functional hemispherectomy patients, mild cerebrospinal fluid infections in 3/27 anatomical hemispherectomy patients, and hydrocephalus requiring shunting in 3/27 functional hemispherectomy patients. A review of the literature and comparison of techniques is presented.
authors.affiliation: Department of Surgery, UCLA Medical Center 90095-7039, USA.
authors.forename: W J
authors.initials: WJ
authors.lastname: Peacock
authors.forename: M C
authors.initials: MC
authors.lastname: Wehby-Grant
authors.forename: W D
authors.initials: WD
authors.lastname: Shields
authors.forename: D A
authors.initials: DA
authors.lastname: Shewmon
authors.forename: H T
authors.initials: HT
authors.lastname: Chugani
authors.forename: R
authors.initials: R
authors.lastname: Sankar
authors.forename: H V
authors.initials: HV
authors.lastname: Vinters
mesh_terms: D000293:Adolescent; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D004292:Dominance, Cerebral / Q000502:physiology*; D004569:Electroencephalography; D004827:Epilepsy / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006429:Hemiplegia / Q000401:mortality / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007223:Infant; D008297:Male; D009460:Neurologic Examination; D011183:Postoperative Complications / Q000401:mortality / Q000503:physiopathology; D012086:Reoperation; D015996:Survival Rate