Diffuse sclerosing osteomyelitis of the mandible: its characteristics and possible relationship to synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome.
OBJECTIVE
This article reports on the possible relationship of diffuse sclerosing osteomyelitis (DSO) of the mandible to synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome.


METHODS
The pathologic features in 12 new DSO patients and those in previously reported cases were reviewed and compared with those of SAPHO syndrome.


RESULTS
Many similarities were noted between the two entities in terms of the clinical, radiographic, and histologic features. Furthermore, multiple bone lesions and skin lesions (palmoplantar pustulosis and psoriasis) were observed not only in SAPHO syndrome but also in DSO patients.


CONCLUSIONS
DSO is concluded to be one manifestation of SAPHO syndrome.
Suei
Y
Y
Department of Oral and Maxillofacial Radiology, Hiroshima University, School of Dentistry, Japan.
Taguchi
A
A
Tanimoto
K
K
D000152:Acne Vulgaris / Q000473:pathology; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015576:Hyperostosis / Q000473:pathology; D008297:Male; D008336:Mandibular Diseases / Q000145:classification* / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D010000:Osteitis / Q000473:pathology; D010019:Osteomyelitis / Q000145:classification / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D011565:Psoriasis / Q000473:pathology; D011859:Radiography; D013577:Syndrome; D013585:Synovitis / Q000473:pathology