Pharmacodynamic behaviour of isolated resistance vessels obtained from hypertensive-diabetic rats.
The influence of various vasodilator and constrictor drugs was studied in isolated mesenteric arteries obtained from obese and lean Zucker rats. The obese Zucker rats were moderately hypertensive and their isolated small arteries were not hypertrophied. All vasoconstrictor agents studied (noradrenaline, methoxamine, serotonin, calcium chloride, potassium chloride) caused the same effects in isolated arteries taken from obese and lean (control) Zucker rats; respectively. In vessels from obese Zucker rats, the vasodilator responses to sodium nitroprusside, methacholine, the K(+)-channel opener cromakalim and nifedipine were the same as in control preparations. In conclusion, isolated mesenteric arteries from obese Zucker rats do not show relevant structural changes, and the pharmacodynamic behaviour of such vessels appears to be the same as that of control preparations. Neither the diabetic hyperinsulinaemic state not the hyperlipoproteinaemia in the obese Zucker rats appear to cause serious vascular damage.
Kam
K L
KL
Department of Pharmacotherapy, Academic Medical Centre, University of Amsterdam, The Netherlands.
Pfaffendorf
M
M
van Zwieten
P A
PA
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology; D001786:Blood Glucose / Q000032:analysis; D015220:Calcium Channels / Q000187:drug effects; D002122:Calcium Chloride / Q000494:pharmacology; D019806:Cromakalim; D005905:Glyburide / Q000494:pharmacology; D006973:Hypertension / Q000503:physiopathology; D066298:In Vitro Techniques; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects; D016210:Methacholine Chloride / Q000494:pharmacology; D008729:Methoxamine / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009543:Nifedipine / Q000494:pharmacology; D009599:Nitroprusside / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D009765:Obesity / Q000503:physiopathology; D015221:Potassium Channels / Q000187:drug effects; D011189:Potassium Chloride / Q000494:pharmacology; D011758:Pyrroles / Q000494:pharmacology; D051381:Rats; D011924:Rats, Zucker; D012701:Serotonin / Q000494:pharmacology; D017540:Tunica Media / Q000033:anatomy & histology; D014655:Vascular Resistance / Q000187:drug effects*; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology
D001578:Benzopyrans; D001786:Blood Glucose; D015220:Calcium Channels; D015221:Potassium Channels; D011758:Pyrroles; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D019806:Cromakalim; D016210:Methacholine Chloride; D009599:Nitroprusside; D012701:Serotonin; D011189:Potassium Chloride; D008729:Methoxamine; D009543:Nifedipine; D002122:Calcium Chloride; D005905:Glyburide; D009638:Norepinephrine