[Features of noradrenaline stimulation of rat liver mitochondria respiration by ADP and calcium ions].
A single administration of a physiological dose of noradrenaline to animals. in contrast to adrenaline, stimulates the respiration of mitochondria not only under oxidation of FAD-dependent Krebbs cycle substrate of the succinase but also HAD-dependent substrate of alpha-ketoglutarate. In the both cases the phosphorylation rate increases, since the action of noradrenaline, separating the respiration and oxidative phosphorylation, was not found. Noradrenaline increases the capacity of mitochondria to more actively absorb calcium ions under oxidation of succinate than under that of alpha-ketoglutarate.
Stefankiv
Iu S
IuS
Babskyĭ
A M
AM
Shostakovska
Y V
YV
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D007656:Ketoglutaric Acids / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D009638:Norepinephrine / Q000502:physiology*; D010085:Oxidative Phosphorylation; D010100:Oxygen / Q000378:metabolism*; D051381:Rats; D013379:Substrate Specificity; D013386:Succinates / Q000378:metabolism
D007656:Ketoglutaric Acids; D013386:Succinates; D000244:Adenosine Diphosphate; D010100:Oxygen; D002118:Calcium; D009638:Norepinephrine