title: A controlled clinical investigation of 3% diclofenac/2.5% sodium hyaluronate topical gel in the treatment of uncontrolled pain in chronic oral NSAID users with osteoarthritis.
abstract: Topical application, 4 times daily for 2 weeks, of the diclofenac-hyaluronan gel to 59 osteoarthritis patients induced a significantly greater (p = 0.057) analgesic effect than placebo gel lacking the active substance applied to 60 control patients.
authors.affiliation: Arthritis Center, Ltd., Phoenix, Arizona 85012, USA.
authors.forename: S H
authors.initials: SH
authors.lastname: Roth
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000700:Analgesics / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004008:Diclofenac / Q000627:therapeutic use*; D005782:Gels; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D010003:Osteoarthritis / Q000188:drug therapy* / Q000503:physiopathology; D010146:Pain; D010166:Palliative Care; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005782:Gels; D004008:Diclofenac; D006820:Hyaluronic Acid