title: Bioactive ent-kaurene diterpenoids from Annona senegalensis.
abstract: Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 microgram/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED50 17-18 micrograms/mL). The structure of the new compound, 3, was deduced from spectral evidence.
authors.affiliation: Department of Chemistry, Bayero University, Kano, Nigeria.
authors.forename: M O
authors.initials: MO
authors.lastname: Fatope
authors.forename: O T
authors.initials: OT
authors.lastname: Audu
authors.forename: Y
authors.initials: Y
authors.lastname: Takeda
authors.forename: L
authors.initials: L
authors.lastname: Zeng
authors.forename: G
authors.initials: G
authors.lastname: Shi
authors.forename: H
authors.initials: H
authors.lastname: Shimada
authors.forename: J L
authors.initials: JL
authors.lastname: McLaughlin
mesh_terms: D000349:Africa; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes