The use of a synthetic prostaglandin E1 analog as a gastric protectant against aspirin-induced hemorrhage in the dog.
Misoprostol prevented gastric hemorrhage in dogs, each of which received aspirin (35 mg/kg body weight, orally q 8 hrs for 10 days). All dogs receiving aspirin alone had gastroscopic and histopathological lesions. No lesions were noted in four of five dogs given aspirin plus misoprostol (15 micrograms/kg body weight, q 8 hrs for five days; then 7.5 micrograms/kg body weight, q 8 hrs for five days). Four of 10 dogs receiving 15 micrograms/kg body weight of misoprostol developed diarrhea. The misoprostol dose was reduced to 7.5 micrograms/kg body weight, and the diarrhea subsided.
Bowersox
T S
TS
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul 55108, USA.
Lipowitz
A J
AJ
Hardy
R M
RM
Johnston
G R
GR
Hayden
D W
DW
Schwartz
S
S
King
V L
VL
D000527:Alprostadil / Q000031:analogs & derivatives*; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D003967:Diarrhea / Q000139:chemically induced / Q000662:veterinary; D004283:Dog Diseases / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005243:Feces / Q000737:chemistry; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000517:prevention & control / Q000662:veterinary*; D006454:Hemoglobins / Q000032:analysis; D008297:Male; D016595:Misoprostol / Q000009:adverse effects / Q000627:therapeutic use; D011465:Prostaglandins, Synthetic / Q000627:therapeutic use*; D013270:Stomach / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D013272:Stomach Diseases / Q000139:chemically induced / Q000517:prevention & control / Q000662:veterinary*
D006454:Hemoglobins; D011465:Prostaglandins, Synthetic; D016595:Misoprostol; D000527:Alprostadil; D001241:Aspirin