title: Lhermitte's sign as a presenting symptom of primary spinal cord tumor.
abstract: We describe a previously healthy 29 year-old man who developed Lhermitte's sign, a shock-like or electric sensation, transmitted down the spine, which occurred during neck flexion or rotation. Evaluation demonstrated an intrinsic, fusiform mass extending from c5 to c7. At operation, the mass was completely removed and found to be a low-grade ependymoma. The sensory phenomena of Lhermitte's sign were most likely caused by tumor-induced distortion and demyelination of cervical dorsal column sensory axons. Lhermitte's sign is most prevalent in patients with multiple sclerosis, cervical spondylotic myelopathy, cisplatin neurotoxicity, cervical radiation injury, and neck trauma. Rarely, Lhermitte's sign occurs with spinal cord compression from epidural or subdural tumor. This patients is the first reported case of an intrinsic spinal cord tumor to present with Lhermitte's sign.
authors.affiliation: Department of Neurology, Ohio State University Hospitals, Columbus, USA.
authors.forename: H B
authors.initials: HB
authors.lastname: Newton
authors.forename: G L
authors.initials: GL
authors.lastname: Rea
mesh_terms: D000328:Adult; D004597:Electroshock; D004806:Ependymoma / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009333:Neck; D009475:Neurons, Afferent / Q000502:physiology; D011187:Posture; D012677:Sensation; D013116:Spinal Cord / Q000473:pathology / Q000503:physiopathology*; D013120:Spinal Cord Neoplasms / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery