Calcification of peripheral nerves in leprosy.
A study conducted in 74 TT/TB patients, with gross thickening of nerves together with nerve abscess, showed calcification in 8 patients. Calcification was most common in the ulnar nerve followed by the lateral popliteal nerve. All eight patients were males with significantly longer duration of illness before start of treatment. Patients with late onset of nerve abscess were found to be more prone to calcium deposition in the nerves. Caseous pus of the abscess had high lipid content with raised cholesterol and cholesterol ester ratio to total lipids suggesting a dystrophic nature of calcification.
Chauhan
S L
SL
NCD, ICMR, New Delhi, India.
Girdhar
A
A
Mishra
B
B
Malaviya
G N
GN
Venkatesan
K
K
Girdhar
B K
BK
D000038:Abscess / Q000382:microbiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D002114:Calcinosis / Q000209:etiology* / Q000378:metabolism; D002648:Child; D002784:Cholesterol / Q000032:analysis; D002788:Cholesterol Esters / Q000032:analysis; D003622:Dapsone / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007917:Leprostatic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D015441:Leprosy, Tuberculoid / Q000150:complications* / Q000188:drug therapy; D008055:Lipids / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000209:etiology* / Q000378:metabolism / Q000382:microbiology; D012293:Rifampin / Q000008:administration & dosage / Q000627:therapeutic use; D013492:Suppuration; D014459:Ulnar Nerve / Q000382:microbiology
D002788:Cholesterol Esters; D007917:Leprostatic Agents; D008055:Lipids; D003622:Dapsone; D002784:Cholesterol; D012293:Rifampin