Clinical use of B- and T-cell gene rearrangement analysis in hematopoietic disorders.
The clinical application of B- and T-cell gene rearrangement analysis is discussed relative to diagnostic problems in specific lymphoproliferative disorders. This article reviews the use of the Southern blot hybridization technique for B- and T-cell gene rearrangement detection in the analysis of various hematopoietic lesions. Several case studies are presented and analyzed.
Krause
J R
JR
Department of Clinical Pathology, Tulane Medical Center, New Orleans, LA 70112, USA.
D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000473:pathology; D001706:Biopsy; D015139:Blotting, Southern; D004247:DNA / Q000032:analysis; D005260:Female; D015322:Gene Rearrangement, B-Lymphocyte; D015329:Gene Rearrangement, T-Lymphocyte; D018095:Germ-Line Mutation; D006679:HIV Seropositivity / Q000150:complications; D006402:Hematologic Diseases / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000235:genetics / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000473:pathology; D018442:Lymphoma, B-Cell, Marginal Zone / Q000145:classification / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000235:genetics / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology
D004247:DNA