Association of factor VII:C levels with environmental and genetic factors in patients with ischaemic heart disease and coronary atheroma characterised by angiography.
Elevated Factor VII:C (FVII:C) levels are an independent risk factor for acute myocardial infarction. To examine the association between FVII:C levels, genetic and environmental factors in patients with a history suggestive of ischaemic heart disease, 270 patients were studied. FVII:C levels were significantly associated with the Msp I and promoter insertion polymorphisms. FVII:C correlated with environmental factors, and these correlations remained when analysed by genotype. In a multiple regression model, genotype, body mass index, cholesterol, triglycerides and gender remained as independent and significant predictors of FVII:C levels. There was no significant difference in FVII:C concentrations with severity of atheroma, or in patients with a history of myocardial infarction. These findings provide further evidence linking FVII:C with Msp I and promoter insertion genotypes and with environmental factors in established IHD, but suggest there is not a genotype-environment interaction or a relationship between FVII:C levels and severity of ischaemic heart disease.
Heywood
D M
DM
Unit of Molecular Vascular Medicine, School of Medicine, University of Leeds, UK.
Ossei-Gerning
N
N
Grant
P J
PJ
D000368:Aged; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D004782:Environmental Health; D005260:Female; D006801:Humans; D008297:Male; D008487:Medical History Taking; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D011110:Polymorphism, Genetic; D013223:Statistics as Topic