title: [Immunotherapy of tumors expressing IGF-I].
abstract: Recently we demonstrated that rat glioma cells when transfected with a vector encoding antisense IGF-I c-DNA lost tumorigenicity and induced a tumor specific immune response involving CD8+ lymphocytes. Here we showed, using immunostaining flow cytometry analysis, that the transfected cell lines, rat C-6 glioma and rat LF hepatoma, expressed an increase level of MHC-class I, and even the amount of MHC-I was found to be higher in the transfected hepatoma, than in the transfected glioma cells. This increased expression of MHC-I could contribute to the final immune recognition of tumour immunogenicity.
authors.affiliation: Centre Hépato-Biliaire, Université Paris-Sud, Villejuif, France.
authors.forename: J
authors.initials: J
authors.lastname: Trojan
authors.forename: H T
authors.initials: HT
authors.lastname: Duc
authors.forename: C
authors.initials: C
authors.lastname: Lafarge-Frayssinet
authors.forename: L C
authors.initials: LC
authors.lastname: Upegui-Gonzales
authors.forename: B
authors.initials: B
authors.lastname: Swiercz
authors.forename: H
authors.initials: H
authors.lastname: Bismuth
authors.forename: F
authors.initials: F
authors.lastname: Hor
authors.forename: D
authors.initials: D
authors.lastname: Anthony
authors.forename: Y
authors.initials: Y
authors.lastname: Guo
authors.forename: J
authors.initials: J
authors.lastname: Ilan
mesh_terms: D000818:Animals; D016373:DNA, Antisense / Q000235:genetics; D005910:Glioma / Q000235:genetics / Q000628:therapy*; D007167:Immunotherapy; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008114:Liver Neoplasms, Experimental / Q000235:genetics / Q000628:therapy*; D051381:Rats; D014162:Transfection
chemical_list: D016373:DNA, Antisense; D007334:Insulin-Like Growth Factor I