Case report: primary splenic non-Hodgkin's B cell lymphoma in a patient with chronic hepatitis C.
A case of primary splenic lymphoma in a patient with chronic hepatitis C is reported. A 69-year-old man with chronic hepatitis C was admitted to Fukuoka City Hospital for evaluation of an enlarging splenic tumour. In the spleen, ultrasonographic examination revealed a hypoechoic tumour and computed tomography demonstrated a non-enhancing low density area measuring 7 cm in diameter; coeliac angiography revealed a hypovascular tumour. Gallium scintigraphy showed uptake of the radioisotope in the splenic tumour. A splenectomy was performed and the morphological and immunohistochemical findings of this tumour were compatible with those of non-Hodgin's B cell lymphoma. Recently, cases of malignant B cell lymphoma associated with hepatitis C virus infection have been reported. Lymphotropism of hepatitis C virus may play a pathological role in the development of non-Hodgkin's lymphoma. We emphasize the importance of considering lymphoma in the differential diagnosis of extrahepatic disorders during the course of chronic hepatitis C virus infections.
Fukutomi
T
T
Department of Internal Medicine, Fukuoka City Hospital, Japan.
Fukushima
M
M
Tanabe
Y
Y
Hiroshige
K
K
Itasaka
H
H
Matsumata
T
T
Kasai
N
N
Yoshida
K
K
Suzumiya
J
J
Kikuchi
M
M
Yufu
Y
Y
Sakai
H
H
Nishimura
J
J
Nawata
H
H
D000368:Aged; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002908:Chronic Disease; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D011859:Radiography; D013160:Splenic Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology