title: Gynandroblastoma of ovary with juvenile granulosa cell component and heterologous intestinal type glands.
abstract: An ovarian gynandroblastoma in a 15-year-old girl is described. The predominant component was juvenile granulosa cell tumour. Areas of adult granulosa cell tumour and Sertoli cell elements were also present. Stromal theca and luteinised cells were identified. An additional histological finding was the presence of heterologous intestinal type glands. There was positive immunohistochemical staining of juvenile and adult granulosa cell areas with inhibin and MIC2 antibodies. Electronmicroscopy showed a close ultrastructural resemblance between tumour cells in granulosa and Sertoli cell areas, in spite of differences in architectural pattern, suggesting that both morphological components may derive from a single cell of origin. The tumour demonstrates a unique combination of elements which has not previously been described.
authors.affiliation: Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland.
authors.forename: W G
authors.initials: WG
authors.lastname: McCluggage
authors.forename: J M
authors.initials: JM
authors.lastname: Sloan
authors.forename: M
authors.initials: M
authors.lastname: Murnaghan
authors.forename: R
authors.initials: R
authors.lastname: White
mesh_terms: D000293:Adolescent; D005260:Female; D006106:Granulosa Cell Tumor / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000473:pathology; D007633:Keratins / Q000032:analysis; D008297:Male; D008854:Microscopy, Electron; D018309:Neoplasms, Gonadal Tissue / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000473:pathology*; D012708:Sertoli Cells / Q000737:chemistry
chemical_list: D007633:Keratins