Oral vaccination against pseudotuberculosis.
Yersinia pseudotuberculosis strain M5 (serogroup IA), isolated from the faeces of a mara, was of considerable virulence for mice by intravenous inoculation, but of low virulence by oral administration, almost always producing no more than a transient infection, mainly of the mesenteric lymph nodes. Oral infection of mice with strain M5, either with a single dose of culture per os or by the administration of dilute culture in drinking water, protected strikingly against the illness and death normally produced by oral infection with virulent strains. Lesions of pseudotuberculosis frequently developed in vaccinated mice as a result of challenge, but such lesions often became sterile. Strain M5 gave protection against four heterologous strains (two serogroup IA, two serogroup IB). These results are of interest in relation to the possible immunization of (1) feral animals, living free in the wild or in animal reserves, and (2) some captive wild species in zoological collections or laboratories.
Thornton
E A
EA
Institute of Zoology, Zoological Society of London, UK.
Smith
G R
GR
D000284:Administration, Oral; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000627:therapeutic use*; D005243:Feces / Q000382:microbiology; D005260:Female; D051379:Mice; D014774:Virulence; D015011:Yersinia pseudotuberculosis / Q000472:pathogenicity; D015012:Yersinia pseudotuberculosis Infections / Q000517:prevention & control*
D001428:Bacterial Vaccines