Glioblastoma multiforme arising in the irradiated spinal cord of a rhesus monkey (Macaca mulatta).
An adult female rhesus monkey that had received 44.0 Gy of cobalt 60 radiation to 8 cm of the cervical and upper thoracic spinal cord approximately 2.8 years postirradiation developed a sudden onset of self-mutilation and loss of function of the right arm followed progressively by loss of function of the left arm and terminally bilateral paresis of the legs. Histopathologic examination of the cervical spinal cord revealed a glioblastoma multiforme that extended from the cervical medullary junction to the sixth cervical vertebrae. Because of the infrequent occurrence of spontaneous neoplasia in rhesus monkeys and the location in the radiation field, the glioblastoma is believed to be radiation induced.
Price
R E
RE
Department of Veterinary Medicine, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Tinkey
P T
PT
Leeds
N E
NE
Hazle
J D
JD
Langford
L A
LA
Stephens
L C
LC
Ang
K K
KK
D000818:Animals; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D005909:Glioblastoma / Q000175:diagnosis / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D008253:Macaca mulatta; D008279:Magnetic Resonance Imaging; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D018419:Primate Diseases; D011833:Radiation Injuries, Experimental; D013116:Spinal Cord / Q000473:pathology / Q000528:radiation effects*; D013119:Spinal Cord Injuries; D013120:Spinal Cord Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000473:pathology / Q000662:veterinary*
D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA