Synthesis and pharmacological profile of some chloroxanthone-1, 4-dihydropyridine derivatives.
A series of xanthone-1,4-dihydrophyridine derivatives bearing a chlorine atom in the xanthone nucleus was prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonist properties. The chlorine introduction in the xanthone moiety slightly affected affinity for cardiac vs. vascular tissues improving to some extent selectivity.
Bisi
A
A
Department of Pharmaceutical Sciences, University of Bologna, Italy.
Budriesi
R
R
Rampa
A
A
Fabbri
G
G
Chiarini
A
A
Valenti
P
P
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D001013:Aorta, Thoracic / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000138:chemical synthesis / Q000494:pharmacology; D002316:Cardiotonic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002317:Cardiovascular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D009928:Organ Specificity
D000889:Anti-Arrhythmia Agents; D002121:Calcium Channel Blockers; D002316:Cardiotonic Agents; D002317:Cardiovascular Agents; D004095:Dihydropyridines