title: Synthesis and biological evaluation of proline derivatives as potential angiotensin converting enzyme inhibitor.
abstract: The synthesis of a series of proline derivatives (1a-e and 2a-b) as pure isomers is described. These compounds were evaluated in vitro for their ability to inhibit angiotensin converting enzyme (ACE) and compared to the potency of captopril taken as a reference drug. They showed only a weak ACE inhibitory activity.
authors.affiliation: Dipartimento di Chimica Farmaceutica e Tossicologica, Università degli Studi di Napoli.
authors.forename: G
authors.initials: G
authors.lastname: Giugliano
authors.forename: P
authors.initials: P
authors.lastname: Grieco
authors.forename: A
authors.initials: A
authors.lastname: Ialenti
authors.forename: M
authors.initials: M
authors.lastname: Mottola
authors.forename: E
authors.initials: E
authors.lastname: Perissutti
authors.forename: V
authors.initials: V
authors.lastname: Santagada
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D009842:Oligopeptides / Q000378:metabolism; D011392:Proline / Q000031:analogs & derivatives* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D009842:Oligopeptides; C010980:hippuryl-histidyl-leucine; D011392:Proline