title: Specific inhibition of human immunodeficiency virus type 1 reverse transcriptase mediated by soulattrolide, a coumarin isolated from the latex of calophyllum teysmannii.
abstract: Soulattrolide (1), a coumarin isolated from Calophyllum teysmannii latex, was found to be a potent inhibitor of HIV-1 reverse transcriptase (RT) with an IC50 of 0.34 microM. Inhibition was remarkably specific, with no appreciable activity being observed toward HIV-2 RT, AMV RT, RNA polymerase, or DNA polymerases alpha or beta.
authors.affiliation: Department of Biochemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
authors.forename: T
authors.initials: T
authors.lastname: Pengsuparp
authors.forename: M
authors.initials: M
authors.lastname: Serit
authors.forename: S H
authors.initials: SH
authors.lastname: Hughes
authors.forename: D D
authors.initials: DD
authors.lastname: Soejarto
authors.forename: J M
authors.initials: JM
authors.lastname: Pezzuto
mesh_terms: D003374:Coumarins / Q000302:isolation & purification* / Q000494:pharmacology; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors*; D015497:HIV-1 / Q000201:enzymology*; D006801:Humans; D007202:Indicators and Reagents; D007840:Latex / Q000737:chemistry; D019384:Nucleic Acid Synthesis Inhibitors; D010946:Plants, Medicinal / Q000737:chemistry*; D018894:Reverse Transcriptase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D016914:Ribonuclease H / Q000037:antagonists & inhibitors
chemical_list: D003374:Coumarins; D007202:Indicators and Reagents; D007840:Latex; D019384:Nucleic Acid Synthesis Inhibitors; D018894:Reverse Transcriptase Inhibitors; C102712:soulattrolide; D054303:HIV Reverse Transcriptase; D012321:DNA-Directed RNA Polymerases; D016914:Ribonuclease H