Human T-and B-cell functions in SCID-hu mice.
SCID mice transplanted with human fetal liver and thymus (SCID-hu Thy/Liv) provide a unique in-vivo model to study human T-cell development and clonal selection mechanisms. This SCID-hu mouse model can be adapted to study the role of thymic epithelial cells, or bone marrow-derived cells in transplantation tolerance. In addition, these mice have circulating human T cells, which mediate human allograft rejection in vivo. SCID-hu mice constructed with fetal bones and thymus (SCID-hu BM/Thy) have both circulating human T and B cells, and can be used to study human B-cell development and B-cell functions. In addition, human T-B-cell interactions resulting in human lg production and the modulating effects of cytokines and cytokine receptor antagonists on this process, can be monitored. Collectively, this information indicates that the SCID-hu mouse is a powerful and versatile model to study human immune responses in vivo.
Roncarolo
M G
MG
Human Immunology, Department, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304-1104, USA.
Carballido
J M
JM
Rouleau
M
M
Namikawa
R
R
de Vries
J E
JE
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D016026:Bone Marrow Transplantation; D006801:Humans; D016031:Liver Transplantation; D051379:Mice; D016513:Mice, SCID; D013154:Spleen / Q000637:transplantation; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000637:transplantation; D014180:Transplantation; D018183:Transplantation Chimera