Platelet serotonergic markers and Tridimensional Personality Questionnaire measures in a clinical sample.
A group of patients with major depressive disorder, with and without comorbid obsessive-compulsive disorder, completed the Tridimensional Personality Questionnaire (TPQ). Harm Avoidance scores were found to be high compared to published age-matched norms and to display a significant positive correlation with Hamilton Depression Rating Scale scores. Platelet 125I-lysergic acid diethylamide (125I-LSD) and 3H-paroxetine binding Bmax values were measured to test Cloninger's hypothesis that Harm Avoidance scores would correlate significantly with measures of serotonergic function. A significant inverse correlation was found between Harm Avoidance scores and 125I-LSD Bmax values. Correlations between 3H-paroxetine Bmax values and TPQ scale scores were not significant. These results suggest an alternative view of the literature relating platelet 5-hydroxytryptamine-2a receptors and mood disorders in that the temperament dimension, Harm Avoidance, may explain prior inconsistencies involving links with depression and suicidality.
Nelson
E C
EC
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
Cloninger
C R
CR
Przybeck
T R
TR
Csernansky
J G
JG
D000328:Adult; D015415:Biomarkers; D001792:Blood Platelets / Q000378:metabolism*; D003866:Depressive Disorder / Q000378:metabolism* / Q000523:psychology; D006801:Humans; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011795:Surveys and Questionnaires
D015415:Biomarkers