Preliminary experience of infusional brachytherapy using colloidal 32P.
In the past, we have clinically evaluated radiolabelled antibodies in Hodgkin's disease and hepatocellular cancer. Increased tumour pressure, reduced vascularity and poor diffusion has limited significant radiolabelled antibody tumour dose deposition. Using intratumoural infusion of macroaggregated albumin to blockade exiting vasculature followed by colloidal chromic 32Phosphorous, we have been able to achieve 75% to 100% tumour dose deposition by interstitial tumour infusion under computerised tomographic guidance. Phase I studies in a variety of solid tumours indicate extremely high doses may be achieved without toxicity (i.e. non-resectable pancreas 900,000 cGy to 1.7 million cGy) with tumour control and remission. This is a review of those studies and how the technique was applied.
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SE
Department of Radiological Physics, Cooper Hospital/University Medical Center, Camden, New Jersey 08103, USA.
Siegel
J A
JA
Principato
R
R
Zeiger
L S
LS
Johnson
E
E
Lang
P
P
Lustig
R
R
Kroprowski
C
C
Wallner
P E
PE
D001254:Astrocytoma / Q000532:radiotherapy; D001918:Brachytherapy / Q000379:methods*; D001932:Brain Neoplasms / Q000532:radiotherapy; D006528:Carcinoma, Hepatocellular / Q000532:radiotherapy; D018288:Carcinoma, Small Cell / Q000532:radiotherapy; D016461:Chemoembolization, Therapeutic; D002857:Chromium; D003102:Colloids / Q000008:administration & dosage / Q000627:therapeutic use; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use; D006258:Head and Neck Neoplasms / Q000532:radiotherapy; D006689:Hodgkin Disease / Q000532:radiotherapy; D006801:Humans; D015552:Injections, Intralesional; D008113:Liver Neoplasms / Q000532:radiotherapy / Q000556:secondary; D008175:Lung Neoplasms / Q000532:radiotherapy; D010190:Pancreatic Neoplasms / Q000532:radiotherapy; D010761:Phosphorus Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use*; D015641:Radiography, Interventional; D016499:Radioimmunotherapy; D011879:Radiotherapy Dosage; D012074:Remission Induction; D012709:Serum Albumin / Q000008:administration & dosage / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
D003102:Colloids; D010761:Phosphorus Radioisotopes; D012709:Serum Albumin; D002857:Chromium; D003907:Dexamethasone