[A new embolic material: super absorbent polymer (SAP) microsphere and its embolic effects].
SAP-Microsphere (sodium acrylic acid-vinyl alcohol copolymer) has the ability to absorb fluids within a few minutes and increase its diameter. Its diameter can also be calibrated. The diameters in ionic contrast material and human serum are 2.1 and 3.5 times larger, respectively, than the original size. It can pass through a microcatheter with an ionic contrast material, and swells at the occluding point into the desired size. It can be recognized under fluoroscopy due to its absorption of contrast material. A total of 10 rabbit kidney embolizations were done followed by resection in 1-14 weeks. Recanalization was absent in all cases. No adhesion to the perirenal tissue was found. Limited reactive change in endothelial cells was found at one week. No changes in the smooth muscle layer were found at any time during the study. Limited infiltration of neutrophil cells was found in perivascular tissue within a period of one week. SAP-Microspheres maintained their spherical shape during a 14-week period. Extensive fibrosis and calcification were found after 4 weeks. SAP-Microspheres are promising as an embolic agent to obtain satisfactory results of embolization therapy.
Jiaqi
Y
Y
Department of Radiology, Osaka University, Medical School.
Hori
S
S
Minamitani
K
K
Hashimoto
T
T
Yoshimura
H
H
Nomura
N
N
Ishida
T
T
Fukuda
H
H
Tomoda
K
K
Nakamura
H
H
D000042:Absorption; D000179:Acrylates; D000818:Animals; D004621:Embolization, Therapeutic; D008863:Microspheres; D010316:Particle Size; D011108:Polymers; D011142:Polyvinyl Alcohol; D011817:Rabbits; D051381:Rats
D000179:Acrylates; D011108:Polymers; D011142:Polyvinyl Alcohol