Relation between infection with human papilloma viruses and expression of p21 and p53 oncoproteins in patients with cancer of the uterine cervix.
Infection with HPV type 16 was demonstrated in 54% of the cases and infection with HPV type 18 in 36.5% of the cases of uterine cervix carcinoma. Both types of viruses were present in 24.3% of the patients. P53 protein accumulation in cell nuclei was observed in 12.2% of the cases of uterine cervix carcinomas and the cases were mostly HPV negative while the cytoplasmic expression of p53 protein was present in 39% of the cases and was frequently accompanied by HPV infection. Presence of p21 protein was detected in 85.3% of the cases, independently of HPV infection or expression of p53 protein.
Bar
J K
JK
Chair of Oncology, Faculty of Medicine, K. Marcinkowski University School of Medicine Poznań, Poland.
Markowska
J
J
Harlozińska
A
A
Sedlaczek
P
P
Nowak
M
M
Roszak
A
A
D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D015689:Oncogene Protein p21(ras) / Q000378:metabolism*; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000378:metabolism* / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D014412:Tumor Virus Infections / Q000378:metabolism* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000821:virology*
D016159:Tumor Suppressor Protein p53; D015689:Oncogene Protein p21(ras)