title: Equivocal evidence of complete carcinogenicity after repeated infection of Syrian hamsters with Opisthorchis viverrini.
abstract: The effects of repeated infection with Opisthorchis viverrini on liver lesion development in male and female Syrian hamsters were investigated over a 1-yr period. Ten monthly intragastric applications of 50, 25, 13, or 0 parasite metacercariae resulted in pronounced proliferative and inflammatory lesions involving the first- and second-order ducts in response to the presence of adult worms. Despite the development of small numbers of putative preneoplastic areas of cholangiofibrosis and morphologically altered hepatocellular foci, no neoplastic lesions were evident at sacrifice after 1 yr. The results thus suggest that parasite infestation is itself not strongly carcinogenic if at all but, rather, that it exerts a marked promoting influence on cholangiocellular and hepatocellular tumor development in the hamster via chronic irritation and increased cell turnover.
authors.affiliation: Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
authors.forename: W
authors.initials: W
authors.lastname: Thamavit
authors.forename: D
authors.initials: D
authors.lastname: Tiwawech
authors.forename: M A
authors.initials: MA
authors.lastname: Moore
authors.forename: N
authors.initials: N
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Shirai
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000633:toxicity; D001652:Bile Ducts / Q000473:pathology; D001661:Biliary Tract Neoplasms / Q000469:parasitology / Q000473:pathology; D001973:Bromodeoxyuridine / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D006224:Cricetinae; D003530:Cyprinidae / Q000469:parasitology*; D005260:Female; D007150:Immunohistochemistry; D008105:Liver Cirrhosis, Biliary / Q000469:parasitology / Q000473:pathology; D008113:Liver Neoplasms / Q000209:etiology* / Q000469:parasitology* / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D009889:Opisthorchiasis / Q000150:complications* / Q000469:parasitology* / Q000473:pathology; D009891:Opisthorchis
chemical_list: D000964:Antimetabolites, Antineoplastic; D001973:Bromodeoxyuridine