Regression of AIDS-related Kaposi's sarcoma during therapy with thalidomide.
A 14-year-old girl with HIV infection and subcutaneous Kaposi's sarcoma (KS) received thalidomide therapy for oral ulcers, resulting in regression of KS lesions, disappearance of KS-associated herpesvirus (KSHV) DNA from blood, and reduced viral load in tumor tissue. Administration of grauntocyte colony-stimulating factor resulted in clinical exacerbation of KS and reappearance of KSHV DNA in blood.
Solèr
R A
RA
Infectious Diseases Unit, University Children's Hospital, Zürich, Switzerland.
Howard
M
M
Brink
N S
NS
Gibb
D
D
Tedder
R S
RS
Nadal
D
D
D000293:Adolescent; D004279:DNA, Viral / Q000097:blood; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications / Q000151:congenital / Q000276:immunology*; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D012074:Remission Induction; D012514:Sarcoma, Kaposi / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D013792:Thalidomide / Q000627:therapeutic use*; D019562:Viral Load
D004279:DNA, Viral; D007166:Immunosuppressive Agents; D016179:Granulocyte Colony-Stimulating Factor; D013792:Thalidomide