A biophysical model for defibrillation of cardiac tissue.
We propose a new model for electrical activity of cardiac tissue that incorporates the effects of cellular microstructure. As such, this model provides insight into the mechanism of direct stimulation and defibrillation of cardiac tissue after injection of large currents. To illustrate the usefulness of the model, numerical stimulations are used to show the difference between successful and unsuccessful defibrillation of large pieces of tissue.
Keener
J P
JP
Department of Mathematics, University of Utah, Salt Lake City 84112, USA. keener@math.utah.edu
Panfilov
A V
AV
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology / Q000628:therapy; D055592:Biophysical Phenomena; D001703:Biophysics; D004554:Electric Countershock; D004594:Electrophysiology; D006321:Heart / Q000502:physiology*; D006801:Humans; D008433:Mathematics; D008564:Membrane Potentials; D008955:Models, Cardiovascular