title: Differential behavioral response to dopamine D2 agonists by sexually naive, sexually active, and sexually inactive male rats.
abstract: This study was performed with male rats categorized as sexually naive (SN), sexually active (SA), or sexually inactive (SI). In a first experiment the effects of dopamine (DA) D2 agonist SND 919 (0.05, 1, and 10 mg/kg) on the copulatory behavior of SN, SA and SI rats were assessed. In a second experiment the DA D2 agonist B-HT 920 (0.2 mg/kg) was used, and examination was limited to SN and SA rats. The effects exerted on stretching-yawning, penile erection, and sedation by the same compounds at the same doses in these three rat categories were also investigated. The main findings were that SND 919 and B-HT 920 facilitated ejaculation in SA rats, and that the rats that were different as regards level of sexual activity exhibited different behavioral responses to the two DA agonists.
authors.affiliation: Department of Biomedical Sciences, University of Modena, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Giuliani
authors.forename: F
authors.initials: F
authors.lastname: Ferrari
mesh_terms: D000818:Animals; D001381:Azepines / Q000494:pharmacology*; D052160:Benzothiazoles; D003307:Copulation / Q000187:drug effects*; D018491:Dopamine Agonists / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004542:Ejaculation / Q000187:drug effects; D008297:Male; D000077487:Pramipexole; D051381:Rats; D017448:Receptors, Dopamine D2 / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: D001381:Azepines; D052160:Benzothiazoles; D018491:Dopamine Agonists; D017448:Receptors, Dopamine D2; D013844:Thiazoles; C024763:talipexole; D000077487:Pramipexole