AIDS in rural Africa: a paradigm for HIV-1 prevention.
Networks of concurrent sexual partnerships may be the primary cause of epidemic spread of HIV-1 in parts of sub-Saharan Africa. This pattern of sexual behaviour increases the likelihood that individuals experiencing primary HIV-1 infection transmit the virus to other persons. Networks of concurrent partnerships are likely to be important in both the early ('epidemic') and late ('endemic') phases of HIV-1 transmission. Interventions should aim to break the sexual networks, whatever the stage of the epidemic. However, prevention of transmission in the endemic phase also requires a greater awareness of early clinical manifestations of HIV-1 infection in the general population. Such awareness, coupled with the availability of condoms and access to HIV-1 testing facilities, may reduce transmission in discordant couples.
Hudson
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CP
D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission*; D000349:Africa / Q000453:epidemiology; D000367:Age Factors; D002944:Circumcision, Male; D003141:Communicable Diseases / Q000150:complications; D017280:Condoms; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission*; D015497:HIV-1; D006801:Humans; D008297:Male; D012725:Sexual Behavior; D012747:Sexual Partners