Severe stealth virus encephalopathy following chronic-fatigue-syndrome-like illness: clinical and histopathological features.
The clinical histories and brain biopsy findings of 3 patients with severe stealth virus encephalopathy are reviewed. The patients initially developed symptoms consistent with a chronic fatigue syndrome. One patient has remained in a vegetative state for several years, while the other 2 patients have shown significant, although incomplete, recovery. Histological and electron-microscopic studies revealed vacuolated cells with distorted nuclei and various cytoplasmic inclusions suggestive of incomplete viral expression. There was no significant inflammatory response. Viral cultures provided further evidence of stealth viral infections occurring in these patients.
Martin
W J
WJ
Center for Complex Infectious Diseases, Rosemead, Calif 91770, USA.
D000328:Adult; D003587:Cytomegalovirus / Q000472:pathogenicity* / Q000648:ultrastructure; D018792:Encephalitis, Viral / Q000209:etiology* / Q000473:pathology*; D015673:Fatigue Syndrome, Chronic / Q000150:complications* / Q000473:pathology*; D005260:Female; D006801:Humans