title: Translocation t(3;17)(q23;q21): a new translocation in acute lymphoblastic leukaemia.
abstract: We report on two adult patients with CD10+ positive acute lymphoblastic leukaemia (ALL) who presented with similar clinical and laboratory features and with a new chromosomal translocation: t(3;17)(q23;q21). This translocation may be involved in the formation of a new chimaeric transcription factor. Both patients shared several poor prognostic factors at presentation and an adverse clinical course. The t(3;17)(q23;q21) translocation may therefore predict a poor outcome in ALL.
authors.affiliation: Institute of Haematology, Chaim Sheba Medical Centre, Tel-Hashomer, Israel.
authors.forename: P
authors.initials: P
authors.lastname: Raanani
authors.forename: M
authors.initials: M
authors.lastname: Berkowicz
authors.forename: E
authors.initials: E
authors.lastname: Rosner
authors.forename: E
authors.initials: E
authors.lastname: Rosenthal
authors.forename: S
authors.initials: S
authors.lastname: Berman
authors.forename: G
authors.initials: G
authors.lastname: Rechavi
authors.forename: I
authors.initials: I
authors.lastname: Ben-Bassat
mesh_terms: D000328:Adult; D002886:Chromosomes, Human, Pair 17; D002893:Chromosomes, Human, Pair 3; D017809:Fatal Outcome; D005801:Genes, Homeobox; D006801:Humans; D007621:Karyotyping; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D014178:Translocation, Genetic