title: Theileria parva (Kasoba): isolation and challenge of cattle recovered from infection with other Theileria parva stocks.
abstract: A pathogenic Theileria stock was isolated from control cattle during an East Coast Fever (ECF) field immunization trial at Kasoba near Karonga town in northern Malawi. A stabilate of this stock caused severe fevers and prolonged parasitosis in Theileria parva naive cattle, resulting in the death of 5 out of 12 cattle despite treatment. In contrast, this parasite stock caused mild to moderate reactions in 17 cattle immunized with the trivalent T. parva stabilate except in 3 animals which developed severe reactions, and one of them died. Another time, cattle immunized with buffalo-derived Theileria parva (Serengeti transformed) resisted a potentially fatal challenge, with only mild to moderate reactions being recorded. The parasite stock was morphologically and serologically indistinguishable from Theileria parva (Muguga); it was virulent and could cause mortality, particularly in T. parva naive cattle. The parasite stock was designated Theileria parva (Kasoba).
authors.affiliation: East Coast Fever vaccine production, Quality Control and Immunization Projects, Lilongwe, Malawi.
authors.forename: F L
authors.initials: FL
authors.lastname: Musisi
authors.forename: J C
authors.initials: JC
authors.lastname: Quiroga
authors.forename: G K
authors.initials: GK
authors.lastname: Kanhai
authors.forename: S P
authors.initials: SP
authors.lastname: Kamwendo
authors.forename: F J
authors.initials: FJ
authors.lastname: Mzoma
authors.forename: L M
authors.initials: LM
authors.lastname: Njuguna
mesh_terms: D000818:Animals; D002417:Cattle; D008295:Malawi; D016797:Theileria parva / Q000145:classification / Q000276:immunology; D013801:Theileriasis / Q000469:parasitology / Q000517:prevention & control*