title: Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95.
abstract: Tumor necrosis factor receptor-1 (TNFR-1) and CD95 (also called Fas or APO-1) are cytokine receptors that engage the apoptosis pathway through a region of intracellular homology, designated the "death domain." Another death domain-containing member of the TNFR family, death receptor 3 (DR3), was identified and was shown to induce both apoptosis and activation of nuclear factor kappaB. Expression of DR3 appears to be restricted to tissues enriched in lymphocytes. DR3 signal transduction is mediated by a complex of intracellular signaling molecules including TRADD, TRAF2, FADD, and FLICE. Thus, DR3 likely plays a role in regulating lymphocyte homeostasis.
authors.affiliation: Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Sciences Inc., 9620 Medical Center Driv.
authors.forename: A M
authors.initials: AM
authors.lastname: Chinnaiyan
authors.forename: K
authors.initials: K
authors.lastname: O'Rourke
authors.forename: G L
authors.initials: GL
authors.lastname: Yu
authors.forename: R H
authors.initials: RH
authors.lastname: Lyons
authors.forename: M
authors.initials: M
authors.lastname: Garg
authors.forename: D R
authors.initials: DR
authors.lastname: Duan
authors.forename: L
authors.initials: L
authors.lastname: Xing
authors.forename: R
authors.initials: R
authors.lastname: Gentz
authors.forename: J
authors.initials: J
authors.lastname: Ni
authors.forename: V M
authors.initials: VM
authors.lastname: Dixit
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D017209:Apoptosis; D002352:Carrier Proteins / Q000378:metabolism; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases; D003001:Cloning, Molecular; D003546:Cysteine Endopeptidases / Q000378:metabolism; D053200:Fas-Associated Death Domain Protein; D015723:Gene Library; D006801:Humans; D008214:Lymphocytes; D008969:Molecular Sequence Data; D016328:NF-kappa B / Q000502:physiology*; D009928:Organ Specificity; D011506:Proteins / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D018124:Receptors, Tumor Necrosis Factor / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D053219:Receptors, Tumor Necrosis Factor, Member 25; D016415:Sequence Alignment; D015398:Signal Transduction; D047990:TNF Receptor-Associated Factor 1; D047992:TNF Receptor-Associated Factor 2; D014162:Transfection; D014407:Tumor Cells, Cultured; D019014:fas Receptor / Q000737:chemistry / Q000502:physiology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; C505533:FADD protein, human; D053200:Fas-Associated Death Domain Protein; D016328:NF-kappa B; D011506:Proteins; D012333:RNA, Messenger; D018124:Receptors, Tumor Necrosis Factor; D053219:Receptors, Tumor Necrosis Factor, Member 25; D047990:TNF Receptor-Associated Factor 1; D047992:TNF Receptor-Associated Factor 2; C506033:TNFRSF25 protein, human; D019014:fas Receptor; C505530:CASP8 protein, human; C506433:CASP9 protein, human; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases; D003546:Cysteine Endopeptidases