Decreased frontal cortical serotonin2A receptors in schizophrenia.
5HT2A receptors were measured in the frontal cortex from schizophrenic and non-schizophrenic subjects. There was a decrease in the density of 5HT2A receptors in Brodmann's areas 8, 9 and 10 from the schizophrenic subjects. In addition, there was an age-dependent decrease in the density of 5HT2A receptors in Brodmann's areas 9 from the non-schizophrenic subjects, which was absent in the schizophrenic subjects. Available evidence does not suggest that the change in 5HT2A receptors in the schizophrenic subjects was a result of drug treatment before death. These data may indicate that decreased 5HT2A receptors in the frontal cortex are involved in the pathology of schizophrenia.
Dean
B
B
Rebecca L. Cooper Research Laboratories, Mental Health Research Institute of Victoria, Parkville, Australia. Bdean@papyrus.mhri.edu.au
Hayes
W
W
D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001344:Autopsy; D005260:Female; D005625:Frontal Lobe / Q000737:chemistry*; D006801:Humans; D007650:Ketanserin / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011985:Receptors, Serotonin / Q000032:analysis*; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology*
D014150:Antipsychotic Agents; D011985:Receptors, Serotonin; D007650:Ketanserin