Processing of hepatitis C virus precursor polyprotein.
To elucidate the possible involvement of hepatitis C virus protein in the development of hepatocellular carcinoma. viral proteins produced from the largest open reading frame of the viral genome were analyzed. The function of each protein in virus replication was also examined. Virus proteins are produced by proteolytic cleavage by cellular and virus encoded proteinases. One of the viral proteins is a phosphoprotein, and the degree of phosphorylation is regulated by another viral protein. This regulation of phosphorylation may play an important role in modulating the proliferation of virus-infected cells.
Shimotohno
K
K
Virology Division, National Cancer Center Research Institute, Tokyo, Japan.
Hijikata
M
M
Tanji
Y
Y
Kaneko
T
T
Satoh
S
S
Tanaka
T
T
Kato
N
N
D016679:Genome, Viral; D016174:Hepacivirus / Q000235:genetics / Q000378:metabolism*; D006526:Hepatitis C / Q000821:virology; D010766:Phosphorylation; D017361:Viral Nonstructural Proteins / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism*; D012324:RNA-Dependent RNA Polymerase
D017361:Viral Nonstructural Proteins; D014764:Viral Proteins; C093542:NS4 protein, hepatitis C virus; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase