title: The synthesis and in vitro antibacterial activity of conformationally restricted quinolone antibacterial agents.
abstract: Two series of conformationally restricted quinolone antibacterials were synthesized. One series was restricted by formation of a tetrahydrofuran ring between the C-6 position and the C-7 position of the quinolone ring skeleton. The second series achieved conformational rigidity by formation of a tetrahydrofuran ring between the C-7 and the C-8 positions. These compounds were evaluated for their in vitro antibacterial activity. Compounds 19 and 20 were the most active compounds in either series and were about equipotent.
authors.affiliation: Anti-infective Research Division, Abbott Laboratories, Abbott Park, IL 60064-3500, USA.
authors.forename: C S
authors.initials: CS
authors.lastname: Cooper
authors.forename: M D
authors.initials: MD
authors.lastname: Tufano
authors.forename: P K
authors.initials: PK
authors.lastname: Donner
authors.forename: D T
authors.initials: DT
authors.lastname: Chu
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin