Nonsteroidal anti-inflammatory drug-induced hepatic disorders. Incidence and prevention.
The nonsteroidal anti-inflammatory drugs (NSAIDs) are the most frequently used medications worldwide for the treatment of a variety of common chronic and acute inflammatory conditions. The association between NSAIDs and liver disease is poorly documented, the exceptions being sulindac and, to a lesser degree, diclofenac. The incidence of liver disease is very low and is relatively unimportant compared with the risk of peptic ulcer disease and gastrointestinal bleeding. Reports of hepatic injury range from insignificant and transient liver enzyme elevation to severe and fulminant hepatitis.
Manoukian
A V
AV
Division of Gastroenterology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, USA.
Carson
J L
JL
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D016022:Case-Control Studies; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D015331:Cohort Studies; D004008:Diclofenac / Q000009:adverse effects; D006801:Humans; D015994:Incidence; D007213:Indomethacin / Q000009:adverse effects; D008099:Liver / Q000187:drug effects; D008107:Liver Diseases / Q000517:prevention & control; D009288:Naproxen / Q000009:adverse effects; D000077431:Oxaprozin; D010653:Phenylbutazone / Q000009:adverse effects; D011422:Propionates / Q000009:adverse effects; D012307:Risk Factors; D013467:Sulindac / Q000009:adverse effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; D004008:Diclofenac; D013467:Sulindac; D009288:Naproxen; D010653:Phenylbutazone; D000077431:Oxaprozin; D007213:Indomethacin