title: Bilateral papilledema with retinal hemorrhages in association with cerebral venous sinus thrombosis and paroxysmal nocturnal hemoglobinuria.
abstract: OBJECTIVE
  To report a patient with paroxysmal nocturnal hemoglobinuria who complained of transient obscurations of vision and exhibited bilateral papilledema with retinal hemorrhages.
  
  
  METHODS
  Case report. Computed tomography did not demonstrate any abnormality but magnetic resonance imaging disclosed signs of cerebral venous sinus thrombosis.
  
  
  RESULTS
  The patient was treated with subcutaneous low molecular weight heparin and intravenous corticosteroids. Symptoms improved within one week and ophthalmoscopic signs resolved within four months.
  
  
  CONCLUSIONS
  Bilateral papilledema with extensive retinal hemorrhages may be a sign of cerebral venous sinus thrombosis, a reported devastating complication of paroxysmal nocturnal hemoglobinuria. Thus, any patient with suspected cerebral venous sinus thrombosis should undergo magnetic resonance imaging, even when results of computed tomography are normal.
authors.affiliation: Eye Department, Kaplan Hospital, Rehovot, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Hauser
authors.forename: N
authors.initials: N
authors.lastname: Barzilai
authors.forename: M
authors.initials: M
authors.lastname: Zalish
authors.forename: M
authors.initials: M
authors.lastname: Oliver
authors.forename: A
authors.initials: A
authors.lastname: Pollack
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D002550:Cerebral Veins / Q000187:drug effects / Q000473:pathology*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications* / Q000188:drug therapy; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009898:Optic Disk / Q000473:pathology; D010211:Papilledema / Q000188:drug therapy / Q000209:etiology*; D011241:Prednisone / Q000627:therapeutic use; D012166:Retinal Hemorrhage / Q000188:drug therapy / Q000209:etiology*; D012851:Sinus Thrombosis, Intracranial / Q000150:complications* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed
chemical_list: D000925:Anticoagulants; D005938:Glucocorticoids; D006495:Heparin, Low-Molecular-Weight; D011241:Prednisone