Understanding drug addiction: implications for treatment.
The addicted brain is qualitatively different from the nonaddicted brain, in ways that include glucose use, gene expression, and responsiveness to environmental cues. Such discoveries place researchers in the early but hopeful stages of translating fundamental findings into new treatments that address the neurobiologic basis of drug craving--even for cocaine, against which there are currently no pharmacologic interventions.
Leshner
A I
AI
National Institute on Drug Abuse, National Institutes of Health, Rockville, Md., USA.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003042:Cocaine / Q000494:pharmacology*; D006801:Humans; D009293:Opioid-Related Disorders / Q000378:metabolism* / Q000628:therapy*; D051381:Rats
D003042:Cocaine