title: Pre-morbid asociality in neuroleptic-resistant and neuroleptic-responsive schizophrenia.
abstract: The purpose of this study was to evaluate whether childhood and adolescent pre-morbid asociality differed in neuroleptic-responsive and neuroleptic-resistant schizophrenia. Pre-morbid asociality was assessed with the Pre-morbid Asociality Adjustment Scale in 411 patients meeting DSM-III-R criteria for chronic schizophrenia or schizoaffective disorder categorized as being either neuroleptic-responsive or neuroleptic-resistant. Patterns of childhood and adolescent asociality were found to be different in neuroleptic-resistant and neuroleptic-responsive patients. Pre-morbid asociality during the pre-adult years was not consistently worse in patients with poor response to neuroleptic treatment. Greater impairment in late adolescent psychosexual functioning was predictive of poor outcome with regard to neuroleptic treatment.
authors.affiliation: Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Findling
authors.forename: K
authors.initials: K
authors.lastname: Jayathilake
authors.forename: H Y
authors.initials: HY
authors.lastname: Meltzer
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000704:Analysis of Variance; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D018450:Disease Progression; D004351:Drug Resistance / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D000297:Psychology, Adolescent; D002666:Psychology, Child; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology; D012737:Sex Factors; D012917:Social Adjustment; D012934:Social Isolation
chemical_list: D014150:Antipsychotic Agents