Inhibitory action of nociceptin on spinal dorsal horn neurones of the rat, in vivo.
Intrathecally administered nociceptin (5, 50, 225 micrograms) dose-relatedly inhibited the C-fibre evoked wind-up and post-discharge of dorsal horn neurones, but not the baseline C-fibre evoked responses. Spinal naloxone 50 micrograms, but not 10 micrograms, reversed the effects of nociceptin. Thus the antinociceptive role of nociceptin in the spinal cord differs from that of classical opioids.
Stanfa
L C
LC
Department of Pharmacology, University College London.
Chapman
V
V
Kerr
N
N
Dickenson
A H
AH
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005727:Ganglia, Spinal / Q000187:drug effects*; D009412:Nerve Fibers / Q000187:drug effects*; D018847:Opioid Peptides / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000187:drug effects*; D000097629:Nociceptin
D018847:Opioid Peptides; D000097629:Nociceptin