Early results with antegrade collagen injection for post-radical prostatectomy stress urinary incontinence.
OBJECTIVE
Results of retrograde transurethral collagen injection for treatment of stress urinary incontinence have been generally disappointing for men with intrinsic sphincter deficiency following radical prostatectomy. We describe a new technique of antegrade transvesical collagen injection using suprapublic percutaneous bladder access.


METHODS
Between October 1994 and January 1996, 20 patients underwent antegrade collagen injection for post-radical prostatectomy stress urinary incontinence. Evaluation by pad test, urodynamics and subjective scores was performed before and after injection.


RESULTS
At a mean followup of 8.5 months 9 of 20 patients (45%) had significant subjective improvement and 5 (25%) were totally dry.


CONCLUSIONS
Antegrade collagen injection is a promising and simple method of correcting post-radical prostatectomy stress urinary incontinence. Further study and longer followup are necessary to determine its precise role in the treatment of this condition.
Klutke
C G
CG
Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Nadler
R B
RB
Tiemann
D
D
Andriole
G L
GL
D000368:Aged; D000369:Aged, 80 and over; D003094:Collagen / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections / Q000379:methods; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy / Q000009:adverse effects*; D013997:Time Factors; D014550:Urinary Incontinence, Stress / Q000209:etiology / Q000628:therapy*
D003094:Collagen