title: Place conditioning with alcohol in alcohol-preferring and -nonpreferring rats.
abstract: A place-conditioning procedure was used to examine the effect of selective breeding for ethanol preference on sensitivity to the rewarding and/or aversive effects of ethanol. On 4 alternate days, groups of seven to eight alcohol-preferring (P) and alcohol-nonpreferring (NP) rats received IP injections of 0.0 (saline controls), 0.5, 1.0, or 1.5 g ethanol/kg body wt. immediately before 15-min confinement in a novel environment. On the 4 intervening days the same rats received saline injections before 15 min confinement in a different environment. On day 9, a 15-min choice test was given with no injections, in which the rats could move freely between the ethanol and the saline-paired environments. Dose-dependent avoidance of the ethanol-paired environment was observed in both lines of rats (1.0 and 1.5 g/kg), but the magnitude of the avoidance was less in the P relative to the NP rats, indicating that ethanol was less aversive for the P rats. No evidence for a place preference was observed in either line with any of the ethanol doses. An innate reduced sensitivity to the aversive effects of ethanol in rats of the P line and/or an enhanced sensitivity to the aversive effects of ethanol in rats of the NP line may contribute to the different levels of oral ethanol self-administration observed in these selectively bred rat lines.
authors.affiliation: Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202, USA.
authors.forename: R B
authors.initials: RB
authors.lastname: Stewart
authors.forename: J M
authors.initials: JM
authors.lastname: Murphy
authors.forename: W J
authors.initials: WJ
authors.lastname: McBride
authors.forename: L
authors.initials: L
authors.lastname: Lumeng
authors.forename: T K
authors.initials: TK
authors.lastname: Li
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012646:Self Administration
chemical_list: D000431:Ethanol