Membranous nephropathy complicating adenolymphoma of the parotid (Warthin's tumour).
Membranous nephropathy has been described in association with many malignancies including various lymphomas. However, it has not been previously described as a complication of benign solid adenolymphoma of the parotid, also called Warthin's tumour. We describe a patient who presented with an adenolymphoma of the parotid, and developed a severe nephrotic syndrome due to membranous nephropathy 6 months after the parotid swelling. The nephrotic syndrome resolved following parotidectomy and a short course of immunosuppression with prednisolone and cyclophosphamide. The possible pathophysiologic mechanisms are discussed.
Kon
S P
SP
Department of Renal Medicine and Transplantation and Histopathology, London Hospital Medical College, UK.
Fan
S L
SL
Kwan
J T
JT
Dodd
S M
SM
Raftery
M J
MJ
D000235:Adenolymphoma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000009:adverse effects / Q000627:therapeutic use; D015433:Glomerulonephritis, Membranous / Q000097:blood / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D011239:Prednisolone / Q000009:adverse effects / Q000627:therapeutic use
D018906:Antineoplastic Agents, Alkylating; D018931:Antineoplastic Agents, Hormonal; D003520:Cyclophosphamide; D011239:Prednisolone