Surgery and polychemotherapy of non-functional endocrine pancreatic tumors: a case report with a dramatic clinical response.
Endocrine pancreatic tumors (EPT) are a rare clinical entity, representing 5% of all pancreatic tumors. Nonfunctional subtypes (NF-EPT) often present themselves at diagnosis in a locally advanced or metastatic stage. Therapeutic planning of these neoplasias is based on a multidisciplinary integration of surgery and medical treatments. The Authors describe a case of NF-EPT with massive metastatic spread after cytoreductive surgery, with impressive response to polychemotherapy with 5-fluorouracil, epirubicin and dacarbazine. The various options concerning chemotherapic treatment of these tumors are reviewed.
Piazza
L
L
Dept. of Endocrine Surgery, University of Catania, Italy.
Ferraù
F
F
Lavenia
G
G
Managò
A
A
Fraggetta
F
F
Cannizzaro
M A
MA
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007515:Islets of Langerhans; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D012074:Remission Induction / Q000379:methods; D014057:Tomography, X-Ray Computed