title: Onset of diabetes with high titer anti-GAD antibody after IFN therapy for chronic hepatitis.
abstract: A case of hyperglycemia induced by the injection of interferon-alpha was experienced in our hospital. This patient showed a sustained high titer of anti-GAD antibody after the onset of diabetes, suggesting that the involvement of immunological disturbance by IFN induces the onset of the disease. However, the susceptibility and the response of the immune system differs from patient to patient, and only limited destruction of beta-cells in the islet of Langerhans and normalization of glucose tolerance by CSII was induced in this patient.
authors.affiliation: Department of Internal Medicine, Mitsui Memorial Hospital, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shiba
authors.forename: Y
authors.initials: Y
authors.lastname: Morino
authors.forename: K
authors.initials: K
authors.lastname: Tagawa
authors.forename: H
authors.initials: H
authors.lastname: Fujino
authors.forename: T
authors.initials: T
authors.lastname: Unuma
mesh_terms: D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D005968:Glutamate Decarboxylase / Q000187:drug effects / Q000276:immunology*; D006521:Hepatitis, Chronic / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D007263:Infusions, Parenteral; D007328:Insulin / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D000998:Antiviral Agents; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D016898:Interferon-alpha; D011994:Recombinant Proteins; D005968:Glutamate Decarboxylase