title: A case of neonatal Bartter's syndrome.
abstract: We describe a child with a neonatal presentation of Bartter's syndrome. Unlike infants previously described with a similar clinical presentation, the urinary excretion rate of prostaglandin E2 in this child was similar to normal children and Tamm-Horsfall protein was distributed normally in the thick ascending limb of the loop of Henle. The child failed to respond to indomethacin alone, but thrived after the addition of the angiotensin converting enzyme inhibitor, captopril.
authors.affiliation: Department of Nephrology, Birmingham Children's Hospital NHS Trust, Ladywood Middleway, UK.
authors.forename: W
authors.initials: W
authors.lastname: Wong
authors.forename: S A
authors.initials: SA
authors.lastname: Hulton
authors.forename: C M
authors.initials: CM
authors.lastname: Taylor
authors.forename: F
authors.initials: F
authors.lastname: Raafat
authors.forename: C J
authors.initials: CJ
authors.lastname: Lote
authors.forename: G
authors.initials: G
authors.lastname: Lindop
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001477:Bartter Syndrome / Q000188:drug therapy / Q000473:pathology*; D002216:Captopril / Q000627:therapeutic use; D015232:Dinoprostone / Q000097:blood; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D007223:Infant; D007668:Kidney / Q000473:pathology; D008138:Loop of Henle / Q000473:pathology; D009088:Mucoproteins / Q000378:metabolism; D011257:Pregnancy Proteins / Q000378:metabolism; D058949:Uromodulin
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000894:Anti-Inflammatory Agents, Non-Steroidal; D009088:Mucoproteins; D011257:Pregnancy Proteins; C548612:UMOD protein, human; D058949:Uromodulin; D002216:Captopril; D015232:Dinoprostone; D007213:Indomethacin