title: Antioxidant properties of the decarboxylated dimer of aminoethylcysteine ketimine.
abstract: The decarboxylated dimer of aminoethylcysteine ketimine has been investigated for a possible general protective effect against oxyradical damage. It has been found that the dimer protects brain microsomes against lipid peroxidation induced by NADPH in the presence of Fe(III)-ADP chelate or by cumene hydroperoxide. The compound also inhibits lipid peroxidation stimulated by L-dopa and related compounds in the presence of Fe(III)-ADP complex. Furthermore the dimer is able to protect deoxyribose against hydroxyl radical induced degradation. These observations suggest that the dimer is a lipid peroxidation protective agent and a free radical scavenger.
authors.affiliation: Dipartimento di Scienze Biochimiche A. Rossi Fanelli, Università di Roma La Sapienza, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Pecci
authors.forename: G
authors.initials: G
authors.lastname: Montefoschi
authors.forename: A
authors.initials: A
authors.lastname: Antonucci
authors.forename: D
authors.initials: D
authors.lastname: Cavallini
mesh_terms: D000244:Adenosine Diphosphate / Q000737:chemistry; D000603:Amino Acids, Sulfur / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology; D002417:Cattle; D066298:In Vitro Techniques; D007501:Iron / Q000737:chemistry; D007980:Levodopa / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects; D008081:Liposomes; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism; D009249:NADP / Q000737:chemistry; D010084:Oxidation-Reduction
chemical_list: D000603:Amino Acids, Sulfur; D000975:Antioxidants; D008081:Liposomes; D007980:Levodopa; D009249:NADP; D000244:Adenosine Diphosphate; C035497:thialysine ketimine; D007501:Iron