title: Myocardial indium-111 antimyosin uptake after uncomplicated coronary artery bypass surgery.
abstract: The prevalence of myocardial damage after coronary artery bypass grafting is related to the criteria of its evaluation. Indium-111 monoclonal antimyosin antibody scintigraphy has been shown to be highly sensitive and specific for even small areas of myocardial necrosis or injury like those of myocarditis or transplant rejection. Our purpose was to evaluate, by using this method, myocardial damage after uncomplicated coronary artery bypass grafting. Uptake of this radio tracer was evaluated after coronary artery bypass grafting in 14 informed and consenting consecutive patients without previous myocardial infarction, with no post-surgical complications and a favorable postoperative course, following coronary artery bypass grafting for stable angina pectoris. Monoclonal antimyosin antibody indium-111 74 MBq (Myoscint Centocor) was injected on the third postoperative day; planar images in the anterior, left anterior oblique 45 degrees and 70 degrees projections were obtained 24 and 48 h later and analyzed for myocardial uptake. Indium-111 antimyosin uptake was present in 10 out of 14 patients (71.4%); it was diffuse in 6 and localized in 4. The ratio of the maximal counts in the myocardium to the counts in the adjacent lung background was measured and found elevated: 1.94 +/- 0.23, higher than the normal values reported in the literature. Indium-111 antimyosin uptake was clear in a group of patients after uncomplicated coronary artery bypass grafting. No correlation was observed between indium-111 antimyosin uptake or heart to lung ratio and creatine kinase, creatine kinase isoenzyme MB, glutamic oxalacetic transferase levels, duration of cardiopulmonary bypass or aortic cross-clamp time, while elevated serum beta myosin heavy chain fragments (IRMA Pasteur) were observed (1378 +/- 238 microU/l). This study suggests that some degree of myocardial damage, though silent, is common after coronary artery bypass grafting.
authors.affiliation: Cattedra di Cardiologia, Università di Parma, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Astorri
authors.forename: G A
authors.initials: GA
authors.lastname: Contini
authors.forename: P
authors.initials: P
authors.lastname: Fiorina
authors.forename: G
authors.initials: G
authors.lastname: Gavaruzzi
authors.forename: F
authors.initials: F
authors.lastname: Fesani
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000601:surgery*; D000911:Antibodies, Monoclonal; D001026:Coronary Artery Bypass; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D015428:Myocardial Reperfusion Injury / Q000000981:diagnostic imaging / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D009218:Myosins / Q000276:immunology*; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity
chemical_list: D000911:Antibodies, Monoclonal; D007205:Indium Radioisotopes; D009218:Myosins