Total cholesterol and high-density lipoprotein levels as risk factors for increased intraocular pressure.
OBJECTIVE
To determine whether high-density lipoprotein and total cholesterol levels were risk factors for increased intraocular pressure in patients with chronic open-angle glaucoma or ocular hypertension.


METHODS
We measured total cholesterol, high-density lipoprotein, and total cholesterol/high-density lipoprotein ratio in 25 patients with open-angle glaucoma or ocular hypertension who had taken no glaucoma medications for four weeks. We individually matched these patients to 25 control subjects who had no history of open-angle glaucoma or ocular hypertension, on the basis of age, race, gender, and history of vascular disease or diabetes mellitus.


RESULTS
We found no statistical difference in the high-density lipoprotein (P = .702) or total cholesterol (P = .177) levels or total cholesterol/high-density lipoprotein ratio between groups (P = .178, paired t test).


CONCLUSIONS
This study indicates that increased high-density lipoprotein and total cholesterol levels are not risk factors for increased intraocular pressure.
Stewart
W C
WC
Department of Ophthalmology, Medical University of South Carolina, USA.
Sine
C
C
Sutherland
S
S
Stewart
J A
JA
D002784:Cholesterol / Q000097:blood*; D002908:Chronic Disease; D005902:Glaucoma, Open-Angle / Q000097:blood*; D006801:Humans; D007429:Intraocular Pressure; D008075:Lipoproteins, HDL / Q000097:blood; D009798:Ocular Hypertension / Q000097:blood*; D012307:Risk Factors
D008075:Lipoproteins, HDL; D002784:Cholesterol