The effect of sulphur mustard on glutathione levels in rat lung slices and the influence of treatment with arylthiols and cysteine esters.
1. Sulphur mustard reacts directly with benzenethiols and cysteine esters in aqueous medium. 2. Benzenethiols diffuse into lung slices in short term culture. 3. Treatment of lung slices in short term culture with benzenethiols does not protect cellular glutathione from conjugation with sulphur mustard. 4. Following uptake of cysteine ester into lung slices cysteine is elevated but this does not protect cellular glutathione from sulphur mustard.
Langford
A M
AM
Department of Environmental and Occupational Medicine, Medical School, University of Newcastle upon Tyne, UK.
Hobbs
M J
MJ
Upshall
D G
DG
Blain
P G
PG
Williams
F M
FM
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D002619:Chemical Warfare Agents / Q000633:toxicity*; D003545:Cysteine / Q000031:analogs & derivatives / Q000494:pharmacology; D005978:Glutathione / Q000378:metabolism*; D008658:Inactivation, Metabolic; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009151:Mustard Gas / Q000633:toxicity*; D010636:Phenols / Q000494:pharmacology; D051381:Rats; D013438:Sulfhydryl Compounds
D002273:Carcinogens; D002619:Chemical Warfare Agents; D010636:Phenols; D013438:Sulfhydryl Compounds; C073222:cysteine isopropyl ester; C042983:thiophenol; D005978:Glutathione; D003545:Cysteine; D009151:Mustard Gas