Neutrophil-rich Ki-1-positive anaplastic large cell lymphoma presenting as a testicular mass.
Ki-1-positive large cell lymphoma is an uncommon subtype of lymphoma that may involve lymph nodes as well as a variety of extranodal locations. To the best of our knowledge, the occurrence of such a tumor in the testis has not been previously documented. We report a case of Ki-1-positive large cell anaplastic lymphoma presenting as a testicular mass in a 56-year old Saudi. Immunohistochemical staining revealed positive staining for Ki-1 and UCHL-1, which indicated a T-cell phenotype. This was further confirmed by polymerase chain reaction analysis, which demonstrated a monoclonal cell population with rearrangement of gamma T-cell receptor. Another interesting morphologic feature was the presence of large numbers of neutrophils throughout the tumor. Similar neutrophil-rich lymphomas have been described recently as a special subtype of Ki-1-positive anaplastic large cell lymphoma.
Akhtar
M
M
Anatomic Pathology Section, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
al-Dayel
F
F
Siegrist
K
K
Ezzat
A
A
D000708:Anaplasia; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D007150:Immunohistochemistry; D017728:Lymphoma, Large-Cell, Anaplastic / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D016133:Polymerase Chain Reaction; D013736:Testicular Neoplasms / Q000276:immunology / Q000473:pathology*