title: Variability in B-mode ultrasound measurements in the atherosclerosis risk in communities (ARIC) study.
abstract: The Atherosclerosis Risk in Communities (ARIC) study is a multicenter, long-term epidemiologic study that uses B-mode ultrasound primarily to measure carotid arterial intima-media wall thickness. To assess the reliability of the measurement process of this application of B-mode technology to population-based research, 36 volunteers from four centers were scanned at three visits, 7-14 days apart. Estimates of the components of variation in the B-mode measurements of artery wall thickness from between-person, between-sonographer, within-sonographer, between-reader and within-reader variation are presented, along with estimates of the correlation R between measures made at repeat visits by different sonographers and read by different readers. The estimates of R for mean intima-media thickness are 0.69, 0.60, 0.54 and 0.66 for the carotid bifurcation, internal carotid, common carotid, and three-segment overall carotid mean, respectively. When these are adjusted to account for differences in between-person variance between the ancillary study and the main ARIC study, the estimated site-specific reliability coefficients appropriate to the ARIC study population are 0.77, 0.73 and 0.70 for mean carotid far-wall intima-media thickness at the carotid bifurcation and the internal and common carotid arteries.
authors.affiliation: Department of Biostatistics, University of North Carolina, Chapel Hill 27514, USA.
authors.forename: L E
authors.initials: LE
authors.lastname: Chambless
authors.forename: M M
authors.initials: MM
authors.lastname: Zhong
authors.forename: D
authors.initials: D
authors.lastname: Arnett
authors.forename: A R
authors.initials: AR
authors.lastname: Folsom
authors.forename: W A
authors.initials: WA
authors.lastname: Riley
authors.forename: G
authors.initials: G
authors.lastname: Heiss
mesh_terms: D000704:Analysis of Variance; D001161:Arteriosclerosis / Q000000981:diagnostic imaging* / Q000453:epidemiology; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D017539:Tunica Intima / Q000000981:diagnostic imaging*; D014463:Ultrasonography / Q000379:methods*; D014481:United States / Q000453:epidemiology