title: In vitro characterization of a fluoropassivated gelatin-impregnated polyester mesh for hernia repair.
abstract: The surgical management of abdominal hernias requires prosthetic grafting in situations where the defect is too large or the surrounding tissue is not available for repair. Flat patches made of different biomaterials have been used in textile or microporous forms. The present work describes the results of an in vitro study comparing the morphological, mechanical, and chemical characteristics of a new textile prototype, Fluoropassiv, made of polyester fibers treated with a fluoropolymer and impregnated with gelatin to those of seven existing commercial meshes and patches made from polypropylene, polyester, polytetrafluoroethylene (PTFE) yarns, and expanded microporous PTFE graft. The morphological study revealed a diversity of structures having a minimal relative porosity of 70%, high bursting, and suture retention strengths in comparison with natural muscular tissue. Elasticmoduli proved to depend more on the direction of the textile the rigidity was higher for those materials having tight structure, like the Fluoropassiv and the Surgipro meshes (> 30 MPa), whereas those with more open structures, such as the Marlex, Trelex, Lars, Bard Teflon, and GoreTex structures, showed lower elastic modulus (10 mPa). In addition, chemical analyses confirmed no irregularities in the polymers used in all prostheses and demonstrated that the fluoropolymer coating of the Fluoropassiv was uniformly distributed. The innovative aspects in the construction of the knitted fabric Fluoropassiv appears to make it suitable for repairing hernias, and the inclusion of both continuous fluoropolymer surface treatment of polyester fibers and gelatin impregnation appears to improve the healing process.
authors.affiliation: Department of Surgery, Laval University, Quebec, Canada.
authors.forename: B M
authors.initials: BM
authors.lastname: Soares
authors.forename: M W
authors.initials: MW
authors.lastname: King
authors.forename: Y
authors.initials: Y
authors.lastname: Marois
authors.forename: R G
authors.initials: RG
authors.lastname: Guidoin
authors.forename: G
authors.initials: G
authors.lastname: Laroche
authors.forename: J
authors.initials: J
authors.lastname: Charara
authors.forename: J F
authors.initials: JF
authors.lastname: Girard
mesh_terms: D001672:Biocompatible Materials; D004355:Drug Stability; D004548:Elasticity; D005780:Gelatin; D006555:Hernia, Ventral / Q000601:surgery*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D011091:Polyesters; D011126:Polypropylenes; D011138:Polytetrafluoroethylene; D011474:Prosthesis Design; D013718:Tensile Strength
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D011126:Polypropylenes; D005780:Gelatin; D011138:Polytetrafluoroethylene