Salivary antibodies to cytomegalovirus (CMV) glycoprotein B accurately predict CMV infections among preschool children.
Among preschool children, we found an association between cytomegalovirus (CMV) infection and salivary immunoglobulin G antibodies to CMV glycoprotein B. All of the 20 infected children had immunoglobulin G to CMV glycoprotein B in their saliva, whereas 38 of 38 uninfected children lacked these antibodies. Testing saliva provides a sensitive and specific alternative to obtaining serum.
Wang
J B
JB
Department of Pediatrics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA.
Adler
S P
SP
D000914:Antibodies, Viral / Q000032:analysis* / Q000276:immunology; D002675:Child, Preschool; D003587:Cytomegalovirus / Q000276:immunology* / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D011237:Predictive Value of Tests; D012463:Saliva / Q000276:immunology* / Q000821:virology
D000914:Antibodies, Viral