title: Craniofacial osteotomies to facilitate resection of large tumours of the anterior skull base.
abstract: Large tumours of the anterior cranial fossa can be a major challenge to the neurosurgeon or the maxillofacial surgeon. However, skull base approaches facilitate their resection. We describe our experience with the extended subfrontal approach in treating tumours of the anterior cranial base. This approach was performed on 29 patients with large tumours of the anterior skull base. The final outcome in all 29 patients was favourable in terms of total resection of the tumour with minimal subsequent neurological deficit. Two patients developed transient oedema of the frontal lobes without persistent neurological sequelae. Another patient developed a postoperative cerebrospinal fluid fistula that was successfully repaired. The patients were followed for a period ranging from 6 to 28 months. There was no recurrence. The operative technique is described. En bloc removal of the roofs of the orbits and part of the anterior cranial fossa permits wide exposure of the lesion with minimal brain retraction. Reconstruction of the anterior cranial base should be meticulous to avoid cerebrospinal fluid leaks and subsequent meningitis. Loss of smell is a sequel to this approach. The possible risks and some important technical details are highlighted.
authors.affiliation: Department of Neurological Surgery, University of Patras, Greece.
authors.forename: F
authors.initials: F
authors.lastname: Tzortzidis
authors.forename: G
authors.initials: G
authors.lastname: Bejjani
authors.forename: T
authors.initials: T
authors.lastname: Papadas
authors.forename: P
authors.initials: P
authors.lastname: Triantafyllou
authors.forename: M
authors.initials: M
authors.lastname: Partheni
authors.forename: P
authors.initials: P
authors.lastname: Goumas
authors.forename: N
authors.initials: N
authors.lastname: Papadakis
mesh_terms: D000236:Adenoma / Q000601:surgery; D000368:Aged; D001929:Brain Edema / Q000209:etiology; D002555:Cerebrospinal Fluid / Q000502:physiology; D003399:Craniotomy / Q000009:adverse effects / Q000379:methods; D005147:Facial Bones / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005624:Frontal Bone / Q000601:surgery; D005625:Frontal Lobe; D006801:Humans; D007427:Intracranial Pressure; D008297:Male; D008577:Meningeal Neoplasms / Q000601:surgery; D008579:Meningioma / Q000601:surgery; D008581:Meningitis / Q000209:etiology / Q000517:prevention & control; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D000857:Olfaction Disorders / Q000209:etiology; D009915:Orbit / Q000601:surgery; D010027:Osteotomy / Q000009:adverse effects / Q000379:methods*; D010911:Pituitary Neoplasms / Q000601:surgery; D012307:Risk Factors; D019291:Skull Base / Q000601:surgery; D019292:Skull Base Neoplasms / Q000601:surgery*; D016896:Treatment Outcome