title: Theophylline intoxication: clinical features and pharmacokinetics during treatment with charcoal hemoperfusion.
abstract: We describe a 50-year-old depressive patient with severe theophylline toxicity that occurred as a result of attempted suicide. Her theophylline levels peaked at 148 mg/l. She was promptly treated with charcoal hemoperfusion, and responded well. We describe the pharmacokinetics of theophylline removal via hemoperfusion, and review the literature.
authors.affiliation: Department of Nephrology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: P
authors.initials: P
authors.lastname: Shechter
authors.forename: H
authors.initials: H
authors.lastname: Berkenstat
authors.forename: E
authors.initials: E
authors.lastname: Segal
authors.forename: J
authors.initials: J
authors.lastname: Rapoport
mesh_terms: D002606:Charcoal; D003866:Depressive Disorder / Q000523:psychology; D016903:Drug Monitoring; D005260:Female; D006464:Hemoperfusion / Q000379:methods; D006801:Humans; D008875:Middle Aged; D011041:Poisoning / Q000628:therapy; D013406:Suicide, Attempted; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D013997:Time Factors
chemical_list: D002606:Charcoal; D013806:Theophylline