[Postoperative urinary ulinastatin secretion and renal function in hepatectomized patients with and without liver cirrhosis].
We compared ulinastatin secretion into urine with renal function during postoperative period in three groups, hepatectomized group with liver cirrhosis (LC(+), n = 7), hepatectomized group without liver cirrhosis (LC(-), n = 4) and subtotal gastrectomized group with normal liver function (GR, n = 7). In LC(+) group, N-acetyl-beta-D-glucosaminidase (NAG) increased above normal upper limit throughout the postoperative period. Ulinastatin (UTI) also increased but the increase was not remarkable. In LC(-) group, NAG increase but not significantly compared with the preoperative value. UTI increased from 5.8 +/- 3.0 IU.mg x Cr-1 to 30.8 +/- 16.6 IU.mg x Cr-1 and 39.9 +/- 9.0 IU. mg x Cr-1 on the 1st and 3rd postoperative day respectively. In GR group, there was no change in NAG value. UTI on the 3rd postoperative day increased significantly (from 10.0 +/- 7.7 to 75.4 +/- 39.0 IU.mg x Cr-1). A small urinary secretion of UTI and increased NAG during postoperative period in LC(+) group suggest that UTI might play an important role in postoperative renal dysfunction in patients with liver cirrhosis.
Ueki
M
M
Department of Anesthesiology, Higashi Osaka Municipal Central Hospital.
Yokono
S
S
Nogaya
J
J
Taie
S
S
Komatsu
H
H
Ogli
K
K
D000118:Acetylglucosaminidase / Q000652:urine; D000368:Aged; D005743:Gastrectomy; D006023:Glycoproteins / Q000652:urine*; D006498:Hepatectomy; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008103:Liver Cirrhosis / Q000503:physiopathology / Q000652:urine*; D008875:Middle Aged; D011184:Postoperative Period; D014361:Trypsin Inhibitors / Q000652:urine*
D006023:Glycoproteins; D014361:Trypsin Inhibitors; D000118:Acetylglucosaminidase; C028665:urinastatin