title: Individual hormone replacement therapy.
abstract: Although hormone replacement therapy is widely used in western countries, compliance is not very good; only a minor proportion of women starting the treatment continue it for over 5 years. However, long-term treatment is essential for primary prevention of cardiovascular diseases and osteoporosis. One reason for low compliance is that treatment is not planned individually. After using a fixed estradiol dose, serum levels of estradiol show 10-fold differences between subjects, independently of the routes of administration. This article briefly summarizes the possibility of using tailored treatment and thus improving long-term compliance with HRT.
authors.affiliation: Department of Obstetrics and Gynecology, Tampere University Hospital, Finland.
authors.forename: R J
authors.initials: RJ
authors.lastname: Tuimala
authors.forename: T
authors.initials: T
authors.lastname: Vihtamäki
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D002979:Climacteric / Q000187:drug effects*; D003362:Cost-Benefit Analysis; D004305:Dose-Response Relationship, Drug; D015914:Estrogen Replacement Therapy / Q000191:economics / Q000379:methods*; D004967:Estrogens / Q000097:blood; D005260:Female; D006801:Humans; D008134:Long-Term Care; D011372:Progestins / Q000008:administration & dosage
chemical_list: D004967:Estrogens; D011372:Progestins