Funguria in cancer patients: analysis of risk factors, clinical presentation and outcome in 50 patients.
Fifty cancer patients with funguria of > 10(5) CFU/ml, dysuria and leukocyturia were retrospectively analyzed for etiology, risk factors and outcome. In 72% of cases Candida albicans and in 28% non-albicans Candida spp. (Candida krusei, Candida tropicalis) and non-Candida spp. yeasts (Blastoschizomyces capitatus) were isolated. Torulopsis glabrata was not found among these patients. The most frequent risk factors were: antibiotic therapy with more than one antibiotic agent (96%), concomitant fungal infection in other localizations than the urinary tract (36%), colonization with the same species (48%), catheterization with urinary catheter or nephrostomy (46%), prophylaxis with quinolones (50%) and previous therapy with corticosteroids (72%). Structural or anatomic malformations of the urinary tract (26%), neutropenia (28%), antifungal prophylaxis with azoles (22%), and diabetes mellitus (12%) were less frequently seen. Thirty of 36 patients treated with systemic antifungals were cured and six were not.
Oravcova
E
E
Dept. of Medicine, University of Trnava, Slovak Republic.
Lacka
J
J
Drgona
L
L
Studena
M
M
Sevcikova
L
L
Spanik
S
S
Svec
J
J
Kukuckova
E
E
Grey
E
E
Silva
J
J
Krcméry
V
V
D001759:Blastomycosis / Q000150:complications / Q000382:microbiology* / Q000503:physiopathology; D002175:Candida / Q000302:isolation & purification*; D002176:Candida albicans / Q000302:isolation & purification*; D002177:Candidiasis / Q000150:complications / Q000382:microbiology* / Q000503:physiopathology; D006801:Humans; D009369:Neoplasms / Q000150:complications / Q000382:microbiology* / Q000503:physiopathology; D009894:Opportunistic Infections / Q000150:complications / Q000382:microbiology* / Q000503:physiopathology; D012189:Retrospective Studies; D012307:Risk Factors