Solvent and plasticizer influences on ethylcellulose-microcapsules.
Variations in microencapsulation processes give rise to different products and it seems there are no firm rules. It is thus difficult to know what kind of product will be obtained before the research is carried out. Changes in temperature, rate, time and type of stirring can cause great modifications in the system, most of which are responsible for variations in standard techniques. In our study, we investigate the solvent influence on ethylcellulose (EC) microcapsule formation. We have selected four different solvents: ethanol as an aqueous solvent and acetone, chloroform and toluene as organic solvents. Diclofenac sodium (DFNa), a non-steroidal anti-inflammatory agent, has been used as an encapsulated substance as it is inactivated in the gastric juices. This polymer and microencapsulation process was selected after an exhaustive study with different polymers and processes. Once the solvent influence was determined, ethylphthalate was incorporated in one type of microcapsule in order to study the influence of this plasticizer on drug release by the modification of film-permeability.
Palomo
M E
ME
Departmento de Farmacia y Tecnologia Farmaceutica, Universidad Complutense de Madrid, Madrid, Spain.
Ballesteros
M P
MP
Frutos
P
P
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism; D002214:Capsules / Q000737:chemistry* / Q000378:metabolism; D002482:Cellulose / Q000031:analogs & derivatives*; D004008:Diclofenac / Q000378:metabolism; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism; D004339:Drug Compounding / Q000379:methods; D008853:Microscopy; D010539:Permeability; D010795:Phthalic Acids / Q000378:metabolism; D010968:Plasticizers / Q000378:metabolism*; D011108:Polymers / Q000737:chemistry / Q000378:metabolism; D012997:Solvents / Q000737:chemistry / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002214:Capsules; D004337:Drug Carriers; D010795:Phthalic Acids; D010968:Plasticizers; D011108:Polymers; D012997:Solvents; D004008:Diclofenac; D002482:Cellulose