Fluvoxamine increases the clozapine serum levels significantly.
In this case report we describe an interaction between clozapine and fluvoxamine in two physically healthy patients meeting the DSM-IIIR criteria for paranoid schizophrenia. The substantial rise of clozapine serum levels suggest that caution should be exercised when combining fluvoxamine with clozapine as the clozapine concentration may increase by a factor of 5-10.
Koponen
H J
HJ
Moisio Hospital, Mikkeli, Finland.
Leinonen
E
E
Lepola
U
U
D000328:Adult; D003024:Clozapine / Q000097:blood* / Q000627:therapeutic use; D004347:Drug Interactions; D016666:Fluvoxamine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy*
D003024:Clozapine; D016666:Fluvoxamine