Serum trypsinogen-2 in the prediction of outcome in acute necrotizing pancreatitis.
BACKGROUND
The accuracy of serum trypsinogen-2 in predicting the severity of acute necrotizing pancreatitis (ANP) was prospectively evaluated in 52 consecutive patients.


METHODS
A new sensitive immunofluorometric assay was used for serum trypsinogen-2,


RESULTS
Mean values during the first 24 h were 42.1 micrograms/l in control patients, 1435 micrograms/l in uncomplicated cases, and 4090 micrograms/l in complicated or fatal cases. There was a significant difference in serum trypsinogen-2 values between patients with uncomplicated and complicated disease (p = 0.002) already on admission. When a cutoff level of 1000 micrograms/l was used, patients with uncomplicated ANP were differentiated from patients with complicated ANP with a sensitivity of 91% and with a specificity of 71%.


CONCLUSIONS
The immunofluorometric assay of serum trypsinogen-2 is a sensitive and specific method for prediction of the severity of the disease in necrotizing pancreatitis.
Sainio
V
V
Dept. II of Surgery, Helsinki University Central Hospital, Finland.
Puolakkainen
P
P
Kemppainen
E
E
Hedström
J
J
Haapiainen
R
R
Kivisaari
L
L
Stenman
U H
UH
Schröder
T
T
Kivilaakso
E
E
D000328:Adult; D000368:Aged; D000681:Amylases / Q000097:blood / Q000652:urine; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D015200:Fluoroimmunoassay; D006801:Humans; D008297:Male; D008875:Middle Aged; D019283:Pancreatitis, Acute Necrotizing / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D014357:Trypsin; D014362:Trypsinogen / Q000097:blood* / Q000652:urine
D015415:Biomarkers; C064831:PRSS2 protein, human; D014362:Trypsinogen; D002097:C-Reactive Protein; D000681:Amylases; D014357:Trypsin