The use of poly R-478 as a marker to determine gastric emptying and intestinal propulsive motility in suckling rats.
During our studies on gastrointestinal motility in suckling rats using 51Cr or 51Cr-EDTA as markers, we noticed that these markers--in contrast to studies in adult rats--"adhered" to the gastrointestinal wall of sucklings. We therefore decided to test the use of another non-absorbable marker Poly R-478 (an acetylated anthrapyridone chromophore linked to an polyamino-ethylene-sodium ethylene sulfonate copolymer backbone developed by the Dynapol Corporation (Palo Alto, CA). This new method has appeared to be useful.
Shinohara
H
H
Department of Pediatrics, University of Arizona, Tucson, USA.
Williams
C
C
Koldovský
O
O
D000818:Animals; D000833:Animals, Suckling / Q000502:physiology*; D000880:Anthraquinones; D004396:Coloring Agents; D005746:Gastric Emptying; D005769:Gastrointestinal Motility; D011108:Polymers; D051381:Rats; D017207:Rats, Sprague-Dawley
D000880:Anthraquinones; D004396:Coloring Agents; D011108:Polymers; C017971:poly R-478