Inhibitory effect of neuropeptide y on epileptiform activity in the frontal cortex and hippocampus in vitro.
The effect of neuropeptide Y on spontaneous epileptiform discharges was studied in cortical and hippocampal slices using an extracellular recording. Epileptiform activity which was induced by superfusion of slices with Mg(2+)-free medium was attenuated by neuropeptide Y (0.5 microM) in both the frontal cortex and hippocampal CA1 pyramidal cells.
Bijak
M
M
Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D004594:Electrophysiology; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D006624:Hippocampus / Q000166:cytology / Q000503:physiopathology*; D066298:In Vitro Techniques; D008274:Magnesium; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009478:Neuropeptide Y / Q000494:pharmacology*; D017397:Prefrontal Cortex / Q000166:cytology / Q000503:physiopathology*; D017966:Pyramidal Cells / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
D000927:Anticonvulsants; D009478:Neuropeptide Y; D008274:Magnesium