Acebutolol overdose treated with hemodialysis and extracorporeal membrane oxygenation.
A case involving a 27-year-old woman who ingested an overdose of acebutolol is presented. Extracorporeal membrane oxygenation was initiated to stabilize the patient's condition before commencing hemodialysis. S-diacetolol (the N-acetelation product of acebutolol) was cleared with hemodialysis. It is suggested that extracorporeal membrane oxygenation may be of short-term benefit in the treatment of overdoses with beta-adrenergic agents such as acebutolol when accelerated clearance with hemodialysis is anticipated.
Rooney
M
M
Department of Anaesthesia, University of Saskatchewan, Saskatoon, Canada.
Massey
K L
KL
Jamali
F
F
Rosin
M
M
Thomson
D
D
Johnson
D H
DH
D000070:Acebutolol / Q000097:blood / Q000506:poisoning*; D000319:Adrenergic beta-Antagonists / Q000097:blood / Q000506:poisoning*; D000328:Adult; D062787:Drug Overdose / Q000628:therapy; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006801:Humans; D006435:Renal Dialysis
D000319:Adrenergic beta-Antagonists; D000070:Acebutolol