Ultrastructural localization of blood group antigens in human salivary glands.
The subcellular distribution of several blood group antigens was studied in human major and minor salivary glands by means of a postembedding immunogold staining method. In each gland, antigens were detected as secretory products and as cell surface components. A, B, H and Lewis (a,b,x,y) antigens were found in mucous cells depending on the ABO and secretor status; reactivities were confined to the secretory granules. In serous and ductal cells, both the secretory granules and cell membranes were reactive, but only for H, Le-b and Le-y irrespective of the ABO and secretor status.
Cossu
M
M
Dipartimento di Citomorfologia, Università di Cagliari, Italy.
Lantini
M S
MS
D000017:ABO Blood-Group System / Q000032:analysis* / Q000276:immunology; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis* / Q000276:immunology; D003594:Cytoplasmic Granules / Q000737:chemistry / Q000276:immunology / Q000648:ultrastructure; D006801:Humans; D018928:Immunity, Mucosal / Q000502:physiology; D007150:Immunohistochemistry; D007983:Lewis Blood Group Antigens / Q000032:analysis / Q000276:immunology; D016253:Microscopy, Immunoelectron; D012469:Salivary Glands / Q000737:chemistry* / Q000648:ultrastructure
D000017:ABO Blood-Group System; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D007983:Lewis Blood Group Antigens