title: Effect of oral terbinafine treatment on cyclosporin pharmacokinetics in organ transplant recipients with dermatophyte nail infection.
abstract: Eleven patients with either kidney, heart or lung transplants, immunosuppressed with cyclosporin A, and with culture-proven dermatophyte toe nail infection, were given 250 mg terbinafine orally daily for 12 weeks. No changes in cyclosporin A dosage were made. A statistically significant decrease in mean specific cyclosporin A blood trough levels was found at 4, 8 and 12 weeks. No other statistically significant changes in the pharmacokinetic profile of cyclosporin A were seen. Terbinafine possibly induces a cyclosporin A metabolic degradation, which, however, is of little clinical significance. Terbinafine treatment is a safe therapeutical option in cyclosporin A-treated patients with dermatophyte nail infection. Cyclosporin A levels should be controlled during treatment.
authors.affiliation: Department of Dermatology, Rikshospitalet, University of Oslo, Norway.
authors.forename: P
authors.initials: P
authors.lastname: Jensen
authors.forename: G
authors.initials: G
authors.lastname: Lehne
authors.forename: P
authors.initials: P
authors.lastname: Fauchald
authors.forename: S
authors.initials: S
authors.lastname: Simonsen
mesh_terms: D000284:Administration, Oral; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003883:Arthrodermataceae; D016572:Cyclosporine / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004347:Drug Interactions; D005500:Follow-Up Studies; D005533:Foot Dermatoses / Q000175:diagnosis; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics* / Q000627:therapeutic use; D016030:Kidney Transplantation; D016040:Lung Transplantation; D009281:Naphthalenes / Q000008:administration & dosage / Q000627:therapeutic use*; D014009:Onychomycosis / Q000188:drug therapy*; D000077291:Terbinafine; D013997:Time Factors
chemical_list: D000935:Antifungal Agents; D007166:Immunosuppressive Agents; D009281:Naphthalenes; D016572:Cyclosporine; D000077291:Terbinafine