title: MR characterization of post-irradiation soft tissue edema.
abstract: OBJECTIVE
  Radiation therapy is often used to treat bone und soft tissue neoplasms, and commonly results in soft tissue edema in the radiation field. However, the time course, distribution and degree of this edema have not been well characterized. Our study was carried out to better define these features of the edema seen following neutron and photon radiation therapy.
  
  
  METHODS
  Two hundred and twenty-six patients underwent radiation therapy as part of combined modality management for musculoskeletal sarcomas between 1985 and 1993. Of these, 15 had surgical resection of their neoplasm, had no clinical evidence of recurrent disease, and had adequate MR follow-up that allowed sequential assessment of soft tissue following irradiation. Ten patients received photons with an average dose of 52.8 Gy. Five patients received neutrons with an average dose of 17.3 nGy. Sequential MR follow-up was available in these patients for an average of 22.8 months following radiation therapy. On each of the serial MR imaging studies, subcutaneous fat, muscle, and the intramuscular septa/fascial planes were graded subjectively as to size and signal intensity.
  
  
  RESULTS
  In general, soft tissue signal intensity in the radiation field initially increased over time, peaking at about 6 months for neutron-treated patients and at about 12-18 months for photon-treated patients. Signal intensity then decreased slowly over time. However, at the end of the follow-up period, signal intensity remained elevated for most patients in both groups. Signal intensity in a particular tissue was greater and tended to persist longer on STIR sequences than on T2-weighted sequences. Survival analysis of signal intensity demonstrated much longer edema survival times for neutron-treated patients than for photon-treated patients. Signal intensity increase in the intramuscular septa persisted for much longer than for fat or muscle. A mild increase in size was noted in the subcutaneous fat and intramuscular septa. Muscle, on the other hand, showed a decrease in size following treatment. This was mild for the photon-treated group and more marked for the neutron-treated group.
  
  
  CONCLUSIONS
  There is a relatively wide variation in the duration and degree of post-irradiation edema in soft tissues. This edema seems to persist longer in the intramuscular septa than in fat or muscle. Although the duration of follow-up was limited, our study suggests that this edema resolves in roughly half the photon-treated patients within 2-3 years post-treatment and in less than 20% of neutron-treated patients by 3-4 years post-treatment. Muscle atrophy was seen in both photon- and neutron-treated patients, but was more severe in the neutron-treated group.
authors.affiliation: Department of Radiology SB-05, University of Washington, Seattle 98195, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Richardson
authors.forename: G C
authors.initials: GC
authors.lastname: Zink-Brody
authors.forename: R M
authors.initials: RM
authors.lastname: Patten
authors.forename: W J
authors.initials: WJ
authors.lastname: Koh
authors.forename: E U
authors.initials: EU
authors.lastname: Conrad
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D001859:Bone Neoplasms / Q000532:radiotherapy; D003131:Combined Modality Therapy; D004487:Edema / Q000209:etiology / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000532:radiotherapy; D009132:Muscles / Q000473:pathology; D011832:Radiation Injuries / Q000473:pathology*; D011879:Radiotherapy Dosage; D012509:Sarcoma / Q000532:radiotherapy; D013997:Time Factors