Respiratory morbidity in young school children born prematurely--chronic lung disease is not a risk factor?
Children born prematurely and recruited into a prospective follow up study were examined at 5 years of age. Our aim was to determine aetiological associations of respiratory symptoms in such children and, in particular, to determine the importance of severe chronic lung disease (CLD, oxygen dependence beyond 36 weeks post conceptional age). Respiratory status was documented from parental history in 103 children of median gestational age 29 weeks (range 23-35), 17 of whom had suffered from severe CLD. In 90 of the 103 children lung function had been assessed at 1 year of age. Regression analysis revealed that neither severe CLD nor other perinatal variables, but only a family history of atopy, significantly related to a positive symptom status. A high airways resistance at 1 year also significantly related to positive symptom status.


CONCLUSIONS
Reduction in severe CLD (oxygen dependence beyond 36 weeks postconceptional age) may make relatively little impact on respiratory morbidity in young school children born prematurely.
Greenough
A
A
Department of Child Health, King's College Hospital, London, UK.
Giffin
F J
FJ
Yüksel
B
B
Dimitriou
G
G
D001997:Bronchopulmonary Dysplasia / Q000150:complications*; D002675:Child, Preschool; D004739:England / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D016015:Logistic Models; D010991:Plethysmography; D011446:Prospective Studies; D015656:Respiratory Mechanics; D012140:Respiratory Tract Diseases / Q000453:epidemiology* / Q000517:prevention & control; D012307:Risk Factors; D018709:Statistics, Nonparametric