title: An early lesion of the lateral septal nuclei produces changes in the forced swim test depending on gender.
abstract: 1. Several pharmacological maneuvers in very young rats produce later changes resembling human depression. 2. Rats were submitted to a wide lesion in lateral septal region at 8th day after birth and forced to swim at maturity. 3. Male lesioned group showed the highest amount of immobility; whereas, female sham lesion group showed a greater response to treatments. 4. A gender-dependent sensitivity to early lateral septal nucleus lesions and to antidepressants are concluded.
authors.affiliation: Departamento de Fisiología, Instituto de Investigaciones Biomédicas, UNAM, México.
authors.forename: C M
authors.initials: CM
authors.lastname: Contreras
authors.forename: H
authors.initials: H
authors.lastname: Lara-Morales
authors.forename: M
authors.initials: M
authors.lastname: Molina-Hernández
authors.forename: M
authors.initials: M
authors.lastname: Saavedra
authors.forename: G
authors.initials: G
authors.lastname: Arrellín-Rosas
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D003672:Defecation / Q000502:physiology; D003863:Depression / Q000523:psychology*; D005260:Female; D008297:Male; D009043:Motor Activity / Q000502:physiology; D051381:Rats; D012727:Sex Characteristics; D013550:Swimming
chemical_list: D000928:Antidepressive Agents