title: 99Tcm-HMPAO brain SPET in patients with pseudotumour cerebri.
abstract: The aim of this study was to look for regional cerebral blood flow (rCBF) abnormalities in patients with a recent diagnosis of pseudotumour cerebri (PTC) and to compare 99Tcm-hexamethylpropylene amine oxime (99Tcm-HMPAO) cerebral single photon emission tomographic (SPET) findings with those of X-ray computed tomography (CT) and magnetic resonance imaging (MRI). Seventeen consecutive patients aged 14-50 years (mean = 29 years) without previous drug treatment for PTC underwent 99Tcm-HMPAO SPET, cranial CT and MRI studies. No patient had evidence of intracranial mass lesions on the CT or MRI scans. Qualitative analysis of the 99Tcm-HMPAO SPET studies revealed impaired rCBF in nine (53%) patients. The CT and MRI studies revealed an empty sella in two patients, dural sinus thrombosis in one and a slit ventricle in another. Eight of the 13 patients with normal CT and MRI results had rCBF abnormalities. In contrast, three patients with CT and MRI abnormalities had a normal 99Tcm-HMPAO scan. Our results suggest that patients with PTC have functional abnormalities that are revealed by 99Tcm-HMPAO brain SPET.
authors.affiliation: Department of Neurology, School of Medicine, Uludag University, Bursa, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Bakar
authors.forename: F
authors.initials: F
authors.lastname: Tamgac
authors.forename: E
authors.initials: E
authors.lastname: Alper
authors.forename: M
authors.initials: M
authors.lastname: Zarifoglu
authors.forename: I
authors.initials: I
authors.lastname: Bora
authors.forename: F
authors.initials: F
authors.lastname: Turan
authors.forename: E
authors.initials: E
authors.lastname: Ogul
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D011559:Pseudotumor Cerebri / Q000175:diagnosis / Q000000981:diagnostic imaging*; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014057:Tomography, X-Ray Computed
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime