Oral transmucosal ketamine: an effective premedication in children.
The oral cavity offers a simple, painless way of drug administration. For this reason, we used oral transmucosal ketamine (5-6 mg.kg-1) for premedication in 25 children and compared it with intranasal ketamine (5-6 mg.kg-1), placebo and intramuscular ketamine (5-6 mg.kg-1). Oral transmucosal ketamine (OTK) provided effective sedation, facilitated i.v. line insertion and was accepted with pleasure by the patients (as lollipops). The lollipops produced a slight increase in gastric volumes but did not affect gastric pH. In conclusion OTK has been shown to be an effective, harmless preoperative medication in paediatric patients.
Cioacă
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Department of Anaesthesiology, Oral and Maxillo-facial Surgery, University of Medicine, Bucharest, Romania.
Canavea
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D000281:Administration, Intranasal; D000284:Administration, Oral; D000778:Anesthetics, Dissociative / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007649:Ketamine / Q000008:administration & dosage*; D008297:Male; D011229:Preanesthetic Medication
D000778:Anesthetics, Dissociative; D007649:Ketamine