Intraventricular neuropeptide Y does not stimulate food intake in the baboon.
In the present study, we examined the ability of the orexigenic peptide neuropeptide Y (NPY) to stimulate feeding when administered into the lateral ventricle of baboons. No increase of either meal size or total daily food intake was observed over the dose range tested (1-30 micrograms). These results suggest that, in the baboon, NPY may not be an orexigen as it is in other species.
Sipols
A J
AJ
Department of Psychology, University of Washington, Seattle 98195, USA.
Figlewicz
D P
DP
Seeley
R J
RJ
Chavez
M
M
Woods
S C
SC
Porte
D
D
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male; D009478:Neuropeptide Y / Q000494:pharmacology*; D010215:Papio
D009478:Neuropeptide Y