The effect of epidural bupivacaine on the fetal electrocardiogram.
Fetal electrocardiogram waveform analysis was used to assess the effect of epidural bupivacaine on the fetal myocardial conducting system by evaluating its effect on the PR interval, RR interval, T/QRS ratio and the PR-RR correlation coefficient. There were no significant changes in either the PR interval or the PR-RR correlation coefficient. There was a significant increase in the fetal heart rate and a significant fall in the T/QRS ratio. Epidural bupivacaine does not alter fetal myocardial conduction as measured by the PR interval and it does not induce ischaemic cardiac changes as assessed by the T/QRS ratio.
Phillips
K
K
Queen Mother's Hospital, Glasgow, Scotland.
Umstad
M P
MP
Donnelly
J G
JG
Cameron
A D
AD
Murphy
K W
KW
D000293:Adolescent; D000328:Adult; D000779:Anesthetics, Local / Q000494:pharmacology*; D002045:Bupivacaine / Q000494:pharmacology*; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D005318:Fetal Heart / Q000187:drug effects*; D006329:Heart Conduction System / Q000187:drug effects*; D006801:Humans; D011247:Pregnancy
D000779:Anesthetics, Local; D002045:Bupivacaine