The immunomodulatory and antitumor activities of lectins from the mushroom Tricholoma mongolicum.
TML-1 and TML-2 were two lectins isolated from the mushroom Tricholoma mongolicum. They did not differ appreciably in their pH stability and cationic requirement for hemagglutinating activity. They both stimulated the production of nitrite ions and activated the macrophages in mice. The two lectins were able to inhibit the growth of implanted sarcoma 180 cells by 68.84% and 92.39% respectively. The growth of tumor cells in the mouse peritoneal cavity was also inhibited by the two lectins with TML-2 expressing a greater potency.
Wang
H X
HX
Department of Biology, The Chinese University of Hong Kong, Shatin.
Liu
W K
WK
Ng
T B
TB
Ooi
V E
VE
Chang
S T
ST
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry* / Q000276:immunology*; D002412:Cations / Q000494:pharmacology; D005656:Fungal Proteins / Q000494:pharmacology*; D006131:Growth Inhibitors / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D037102:Lectins / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009573:Nitrites / Q000494:pharmacology; D012510:Sarcoma 180; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects
D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D002412:Cations; D005656:Fungal Proteins; D006131:Growth Inhibitors; D037102:Lectins; D009573:Nitrites; D014409:Tumor Necrosis Factor-alpha