Pharmacokinetic studies of the fragrance compound 1,8-cineol in humans during inhalation.
The present study was undertaken to investigate the pharmacokinetics of 1,8-cineol in human subjects during prolonged inhalation. The results showed that 1,8-cineol is well absorbed from breathing air, with a peak plasma concentration after approximately 18 min. The elimination of this fragrance compound from the blood is biphasic, with a mean distribution half-life of 6.7 min and an elimination half-life of 104.6 min.
Jäger
W
W
Department of Radiology, University of Vienna, Austria.
Nasel
B
B
Nasel
C
C
Binder
R
R
Stimpfl
T
T
Vycudilik
W
W
Buchbauer
G
G
D000280:Administration, Inhalation; D000328:Adult; D003511:Cyclohexanols; D000077591:Eucalyptol; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008610:Menthol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D039821:Monoterpenes; D010476:Perfume; D013729:Terpenes
D003511:Cyclohexanols; D039821:Monoterpenes; D010476:Perfume; D013729:Terpenes; D008610:Menthol; D000077591:Eucalyptol