title: Epidermolysis bullosa dystrophica of Hallopeau-Siemens and squamous-cell carcinoma: a case report.
abstract: A 46-year-old patient suffering from Hallopeau-Siemens type epidermolysis bullosa dystrophica presented a large squamous-cell carcinoma of the left hand. No metastases were observed. The tumour was resected and the phalanxes were amputated. The wound was covered with autologous skin grafts. Squamous-cell carcinoma is extremely aggressive in these patients and surgery is the only effective therapy. This life-threatening complication should always be kept in mind and a biopsy taken of every chronic, non-healing ulceration and of each atypical lesion.
authors.affiliation: Department of Dermatology, Katholieke Universiteit Leuven, Universitair Ziekenhuis Sint-Rafael, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Van Rengen
authors.forename: H
authors.initials: H
authors.lastname: Degreef
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000601:surgery; D016108:Epidermolysis Bullosa Dystrophica / Q000150:complications*; D005260:Female; D006225:Hand / Q000473:pathology / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D012878:Skin Neoplasms / Q000150:complications* / Q000601:surgery