Serum and erythrocyte magnesium in critically ill patients.
OBJECTIVE
To evaluate the prevalence of serum and erythrocyte magnesium (Mg) abnormalities in patients on admission to the intensive care unit (ICU) and to test the hypothesis that low levels of Mg are associated with a higher mortality.


METHODS
Prospective study.


METHODS
14-bed ICU in a 1000-bed teaching hospital.


METHODS
179 consecutive patients admitted over a 4-month period.


METHODS
Total serum Mg (Mgs) and erythrocyte Mg (Mge) were determined on admission by atomic absorption spectrophotometry. Severity of illness was assessed by Acute Physiology and Chronic Health Evaluation (APACHE) II and the number of organ system failures (OSF) during the first 24 h. The patients were followed up until discharge from hospital.


RESULTS
On admission, 79 patients (44%) were hypomagnesemic and 10 (6%) were hypermagnesemic. A low level of Mge was observed in 119 patients (66%). In patients with similar APACHE II scores and OSF numbers, more of those with hyperMgs died during their ICU stay. However, the Mge value on admission did not correlate with patient outcome.


CONCLUSIONS
We confirm the high prevalence of Mgs abnormalities as well as Mg deficiency on admission to a medical ICU. Low levels of Mgs and Mge are not associated with higher fatality. HyperMgs was associated with patient death.
Guérin
C
C
Service de Réanimation Médicale, Centre Hospitalier et Universitaire Lyon-Sud, France.
Cousin
C
C
Mignot
F
F
Manchon
M
M
Fournier
G
G
D018806:APACHE; D000704:Analysis of Variance; D016638:Critical Illness / Q000401:mortality; D004912:Erythrocytes / Q000737:chemistry*; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D008274:Magnesium / Q000097:blood*; D008275:Magnesium Deficiency / Q000097:blood / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D011446:Prospective Studies; D013054:Spectrophotometry, Atomic
D008274:Magnesium