Immunological analysis of organized pneumonia with eosinophilic pleural effusion.
A 73-year-old man developed organized pneumonia with severe right-sided eosinophilic pleural effusion (PE). CD69+ and HLA-DR+ eosinophils in PE were 90 and 31%, respectively, but were undetectable in peripheral blood (PB). CD4+, CD45RA+ (naive) and CD4+, CD45RO+ (memory) cells in PB, PE and bronchoalveolar lavage (BAL) were 10.9, 8.4, 2.5 and 22.7, 38.3 and 16.4%, respectively. CD8+, CD45RA+ (naive) and CD8+, CD45RO+ (memory) cells in PB, PE and BAL were 3.5, 4.7, 1.0, and 8.9, 11.3 and 46.0%, respectively. The concentrations of interleukin-5 (IL-5) and IL-6 in PE were 1,680 and 2,797 pg/ml, respectively; however, these cytokines were undetectable in PB. The patient died 1 month after surgery to remove right thickened pleura. Microscopic findings showed right fibrinous pleuritis and organized pneumonia.
Hossain
M
M
First Department of Internal Medicine, University of Tokyo, Japan.
Okubo
Y
Y
Yamaguchi
S
S
Horie
S
S
Itoh
S
S
Sugii
S
S
Takatsu
K
K
Oguchi
T
T
Sekiguchi
M
M
D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology / Q000276:immunology; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D004804:Eosinophils / Q000276:immunology*; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D015848:Interleukin-5 / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis; D037181:Lectins, C-Type; D017493:Leukocyte Common Antigens / Q000032:analysis; D008297:Male; D010996:Pleural Effusion / Q000276:immunology; D011657:Pulmonary Eosinophilia / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D000099192:CD69 Antigens
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D015704:CD4 Antigens; D016827:CD8 Antigens; D006684:HLA-DR Antigens; D015848:Interleukin-5; D015850:Interleukin-6; D037181:Lectins, C-Type; D017493:Leukocyte Common Antigens; D000099192:CD69 Antigens