title: A new prenylated flavonol from the root of Petalostemon purpureus.
abstract: A new prenylated flavonol, petalopurpurenol (1), and a known dihydroflavonol, petalostemumol (2), have been isolated by DNA scission-guided fractionation of the organic portion of a 20% MeOH/CHCl3/H2O partition of a 50% MeOH/CHCl3 extract of the roots of Petalostemon purpureus. Compound 2 displayed moderate activity in DNA-scission assay. Both compounds 1 and 2 were evaluated for cytotoxicity in a panel of human cancer cell lines. The structures of petalopurpurenol (1) and petalostemumol (2) were determined by spectroscopic analysis.
authors.affiliation: Chemistry and Life Sciences Group, Research Triangle Institute, Research Triangle Park, North Carolina 27709, USA.
authors.forename: L
authors.initials: L
authors.lastname: Huang
authors.forename: F
authors.initials: F
authors.lastname: Fullas
authors.forename: R J
authors.initials: RJ
authors.lastname: McGivney
authors.forename: D M
authors.initials: DM
authors.lastname: Brown
authors.forename: M C
authors.initials: MC
authors.lastname: Wani
authors.forename: M E
authors.initials: ME
authors.lastname: Wall
authors.forename: J C
authors.initials: JC
authors.lastname: Tucker
authors.forename: C W
authors.initials: CW
authors.lastname: Beecher
authors.forename: J M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: A D
authors.initials: AD
authors.lastname: Kinghorn
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004249:DNA Damage; D018432:Drug Resistance, Multiple; D004354:Drug Screening Assays, Antitumor; D007887:Fabaceae / Q000737:chemistry*; D006801:Humans; D007624:KB Cells; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal
chemical_list: D000972:Antineoplastic Agents, Phytogenic