title: The Asp9 Asn mutation in the lipoprotein lipase gene is associated with increased progression of coronary atherosclerosis. REGRESS Study Group, Interuniversity Cardiology Institute, Utrecht, The Netherlands. Regression Growth Evaluation Statin Study.
abstract: BACKGROUND
  Many patients suffering from premature coronary artery disease report a family history for such events. A mutation in a particular gene, which confers susceptibility for atherosclerosis, will be found more frequently in individuals suffering from coronary atherosclerosis than in the general population. We have recently reported the identification of an Asp9 Asn substitution in the lipoprotein lipase (LPL) enzyme. We analyzed the impact of this mutation on the progression of coronary atherosclerosis and the effect of pravastatin in both carriers and noncarriers.
  
  
  RESULTS
  All patients were enrolled in the quantitative coronary angiographic clinical trial REGRESS, which studied the impact of pravastatin therapy on coronary atherosclerosis. The Asp9 Asn mutation was identified in 38 of 819 (4.8%) patients. Carriers of the mutation more often had a positive family history of cardiovascular disease and lower HDL cholesterol levels than noncarriers. In the placebo group, carriers showed more progression of coronary atherosclerosis than noncarriers: mean reduction of the minimum obstruction diameter of -0.25 mm versus -0.12 mm (P = .029) and increase of percentage diameter stenosis of 6.4% versus 1.4% (P = .004). Moreover, the adjusted relative risk for a clinical event for carriers was calculated at 2.16 (95% CI, 1.09 to 4.29; P = .027). Although the lipid-lowering effect of pravastatin was attenuated in carriers, it appeared that these patients showed a response similar to noncarriers in terms of less progression of atherosclerosis and event-free survival.
  
  
  CONCLUSIONS
  This study shows that heterozygosity for a mutation in the LPL gene, which causes only subtle changes in fasting plasma lipids, may promote the progression of coronary atherosclerosis and diminish clinical event-free survival.
authors.affiliation: Department of Cardiology, University Hospital, Leiden, The Netherlands.
authors.forename: J W
authors.initials: JW
authors.lastname: Jukema
authors.forename: A J
authors.initials: AJ
authors.lastname: van Boven
authors.forename: B
authors.initials: B
authors.lastname: Groenemeijer
authors.forename: A H
authors.initials: AH
authors.lastname: Zwinderman
authors.forename: J H
authors.initials: JH
authors.lastname: Reiber
authors.forename: A V
authors.initials: AV
authors.lastname: Bruschke
authors.forename: J A
authors.initials: JA
authors.lastname: Henneman
authors.forename: G P
authors.initials: GP
authors.lastname: Molhoek
authors.forename: T
authors.initials: T
authors.lastname: Bruin
authors.forename: H
authors.initials: H
authors.lastname: Jansen
authors.forename: E
authors.initials: E
authors.lastname: Gagné
authors.forename: M R
authors.initials: MR
authors.lastname: Hayden
authors.forename: J J
authors.initials: JJ
authors.lastname: Kastelein
mesh_terms: D000595:Amino Acid Sequence; D015906:Angioplasty, Balloon, Coronary; D015331:Cohort Studies; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000235:genetics* / Q000503:physiopathology* / Q000628:therapy; D018450:Disease Progression; D004311:Double-Blind Method; D005796:Genes; D006579:Heterozygote; D006801:Humans; D008055:Lipids / Q000097:blood; D008071:Lipoprotein Lipase / Q000235:genetics*; D008074:Lipoproteins / Q000097:blood; D008875:Middle Aged; D009154:Mutation; D017035:Pravastatin / Q000627:therapeutic use
chemical_list: D008055:Lipids; D008074:Lipoproteins; D008071:Lipoprotein Lipase; D017035:Pravastatin