[Assessment of cancer risk in the general population of Poland due to asbestos exposure. I. Basis of methodology].
Two mathematical models facilitating calculation of cancer risk in people exposed to asbestos dust in the communal environment are discussed. The first helps determine a dose-response relationships when lung cancer is the exposure effect whereas the second permits calculating the probability of pleural or peritoneal mesotheliomas induction based on the level of asbestos exposure. In the case of lung cancer, the exposure is measured as a cummulated dose which equals to a product of an average concentration of asbestos fibres in 1 ml of the air multiplied by duration of exposure (in years). Thus determined relationship between asbestos exposure and the risk involved is a linear function. The effect of smoking, which undoubtedly accounts for lung cancer induction, is an element of the assessment in this model. The relationship between the risk of mesothelioma and exposure level, which is a non-linear function, is associated with the duration of exposure (in years) and the number of years since first asbestos exposure, however, it is not related to the age of person when first exposure occured or smoking habit. It may assumed that, in the case of environmental exposures, the level of exposure could be measured by the duration of exposure to a determined concentration (the exposure starts at birth to be continued throughout the whole lifetime until death). The models presented allow forecasting cancer risk based on the adopted level and duration of exposure to asbestos dust.
Szymczak
W
W
Zespół Srodowiskowych Zagrozeń Zdrowia Instytutu Medycyny Pracy w Lodzi.
Szeszenia-Dabrowska
N
N
Wilczyńska
U
U
D000368:Aged; D001194:Asbestos / Q000009:adverse effects*; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000009:adverse effects*; D062665:Epidemiological Monitoring; D005260:Female; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000453:epidemiology / Q000209:etiology; D015233:Models, Statistical; D010534:Peritoneal Neoplasms / Q000453:epidemiology* / Q000209:etiology; D011044:Poland / Q000453:epidemiology; D012142:Respiratory Tract Neoplasms / Q000453:epidemiology* / Q000209:etiology; D012306:Risk
D004785:Environmental Pollutants; D001194:Asbestos