Brainstem auditory evoked potentials in epileptics on different anti-epileptic drugs.
The effects of anti-epileptic drugs (AEDs) on brainstem auditory evoked potentials (BAEPs) were studied on 32 female patients of epilepsy and 10 age-matched normal healthy females (NS). The patients were divided into 6 groups, those not receiving medication (drug free, DF) and those receiving AEDs: Phenytoin (PHT), Carbamazepine (CBZ), Phenobarbital (PB), a combination of PHT and PB and a combination of CBZ and PB. DF epileptics had shortened were V absolute latency (AL) and I-V interpeak latency (IPL) as compared to NS. Phenytoin and CBZ monotherapy produced a prolongation of wave III AL (by PHT only), wave V AL, wave I-III IPL and I-V IPL, as compared to DF epileptics. Phenytoin monotherapy also prolonged wave III AL and I-III IPL, as compared to NS. When PB in the dosage of 30-60 mg/d was used in combination with PHT the above mentioned changes were not observed. These findings indicate altered neuronal conduction and/or synaptic transmission in epileptics. Anti-epileptic drugs in the dosages studied, with exception of PHT appear to lead towards "normalization" of BAEPs.
Panjwani
U
U
Defence Institute of Physiology and Allied Sciences, Timarpur, Delhi.
Singh
S H
SH
sel Vamurthy
W
W
Gupta
H L
HL
Mukhopadhyay
S
S
Thakur
L
L
D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use; D004338:Drug Combinations; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D010634:Phenobarbital / Q000627:therapeutic use; D010672:Phenytoin / Q000627:therapeutic use
D000927:Anticonvulsants; D004338:Drug Combinations; D002220:Carbamazepine; D010672:Phenytoin; D010634:Phenobarbital