title: Ability of different flavonoids to inhibit the procoagulant activity of adherent human monocytes.
abstract: Sixty-five natural flavonoids of various chemical classes were screened for their ability to inhibit the procoagulant activity of adherent human monocytes stimulated by endotoxin and interleukin-1 beta in vitro. Eighteen of these compounds inhibited the interleukin-1 beta-induced expression of tissue factor on human monocytes, but the most active compound was a biflavonoid: hinokiflavone.
authors.affiliation: Sanofi Recherche, Toulouse, France.
authors.forename: A
authors.initials: A
authors.lastname: Lale
authors.forename: J M
authors.initials: JM
authors.lastname: Herbert
authors.forename: J M
authors.initials: JM
authors.lastname: Augereau
authors.forename: M
authors.initials: M
authors.lastname: Billon
authors.forename: M
authors.initials: M
authors.lastname: Leconte
authors.forename: J
authors.initials: J
authors.lastname: Gleye
mesh_terms: D000595:Amino Acid Sequence; D001777:Blood Coagulation / Q000187:drug effects*; D002448:Cell Adhesion / Q000187:drug effects; D004731:Endotoxins / Q000494:pharmacology; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000494:pharmacology; D008969:Molecular Sequence Data; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism
chemical_list: D004731:Endotoxins; D005419:Flavonoids; D007375:Interleukin-1