Synthesis of 4,17-diazasteroid inhibitors of human 5 alpha-reductase.
The synthesis of the 17-aza isomer of finasteride is described. With the side chain amide group of the compound existing in the Z configuration the structure is similar to one of the two favored conformations of finasteride. A series of 4,17-diazasteroids was assayed against the isoenzymes of human 5 alpha-reductase.
Morzycki
J W
JW
Institute of Chemistry, University of Warsaw, Białystok Branch, Poland.
Lotowski
Z
Z
Wilczewska
A Z
AZ
Stuart
J D
JD
D058891:5-alpha Reductase Inhibitors; D002855:Chromatography, Thin Layer; D018120:Finasteride / Q000031:analogs & derivatives*; D006801:Humans; D007536:Isomerism; D008958:Models, Molecular
D058891:5-alpha Reductase Inhibitors; D018120:Finasteride