title: Bioactive steroidal alkaloids from Solanum umbelliferum.
abstract: Bioassay-directed fractionation of the MeOH extract of Solanum umbelliferum afforded solasodine (1), O-acetylsolasodine (2), and solasodine 3-O-beta-D- glucopyranoside (3). Alkaloids 1 and 2 exhibited significant activity toward DNA repair-deficient yeast mutants, whereas 3 and the synthetic analogues N-acetylsolasodine (4) and N,O-diacetylsolasodine (5) were found to be inactive. Compounds 2 and 3 are new natural products.
authors.affiliation: Department of Chemistry, Virginia Polytechnic Institute, Blacksburg 24061-0212, USA.
authors.forename: Y C
authors.initials: YC
authors.lastname: Kim
authors.forename: Q M
authors.initials: QM
authors.lastname: Che
authors.forename: A A
authors.initials: AA
authors.lastname: Gunatilaka
authors.forename: D G
authors.initials: DG
authors.lastname: Kingston
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects; D004271:DNA, Fungal / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D012991:Solanaceous Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D013256:Steroids / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004271:DNA, Fungal; D012991:Solanaceous Alkaloids; D013256:Steroids