title: Morphological studies of skeletal muscle in lactic acidosis.
abstract: This paper underscores the contribution of routine morphological examination of skeletal muscle in patients with lactic acidosis. Mitochondrial disorders are by far the most common causes of primary lactic acidosis, in which muscle biopsy analysis helps in diagnosis and in the search for the molecular anomalies. Thus, we focus our attention on one particular point: the contribution of the morphological study of muscle biopsy in primary lactic acidosis due to mitochondrial disorders, especially mitochondrial respiratory-chain diseases.
authors.affiliation: Laboratoire de Pathologie Musculaire, Hôpital Robert Debré, Paris, France.
authors.forename: N B
authors.initials: NB
authors.lastname: Romero
authors.forename: A
authors.initials: A
authors.lastname: Lombès
authors.forename: G
authors.initials: G
authors.lastname: Touati
authors.forename: O
authors.initials: O
authors.lastname: Rigal
authors.forename: P
authors.initials: P
authors.lastname: Frachon
authors.forename: M A
authors.initials: MA
authors.lastname: Cheval
authors.forename: M
authors.initials: M
authors.lastname: Giraud
authors.forename: S
authors.initials: S
authors.lastname: Possekel
authors.forename: M
authors.initials: M
authors.lastname: Fardeau
authors.forename: H
authors.initials: H
authors.lastname: Ogier de Baulny
mesh_terms: D000140:Acidosis, Lactic / Q000201:enzymology / Q000235:genetics / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D002648:Child; D004272:DNA, Mitochondrial / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018482:Muscle, Skeletal / Q000201:enzymology / Q000473:pathology*; D009154:Mutation
chemical_list: D004272:DNA, Mitochondrial