Evolution of the bone-titanium interface on implants coated/noncoated with xenogeneic bone particles: quantitative microscopic analysis.
Titanium cylinders having a sandblasted surface were implanted in holes drilled in the internal condyles of rabbit femurs. The right side received a titanium implant coated with xenogeneic bone particles and the left side received a titanium cylinder alone and was used as control. The femoral extremities were removed at 1, 2, and 3 months postsurgery and embedded undecalcified in methacrylic resins. Sections were studied by quantitative analysis and the interface contact between bone and titanium was measured at two microscopic magnifications due to the fractal dimension of this parameter. In addition the amount of bone volume in a given referent volume provided automatically by the image analyzer was obtained. No differences could be evidenced between the two series of implants, supporting the view that xenogeneic particles were ineffective in improving the attachment of bone to the implant. The bone-to-implant interface measured at the low magnification reflected the anchorage of the implant. In both series a progressive increase upon time of the bone-to-implant interface at the highest microscopic magnification evidenced the importance of late remodeling changes responsible for bone bonding and the fractal characteristics of this interface, related to surface quality of the implant responsible for stress transfer.
Chappard
D
D
Laboratoire d'Histologie-Embryologie, Faculté de Médecine, Angers, France.
Grizon
F
F
Brechet
I
I
Baslé
M F
MF
Rebel
A
A
D000704:Analysis of Variance; D000818:Animals; D001672:Biocompatible Materials; D016025:Bone Transplantation / Q000379:methods*; D002417:Cattle; D005269:Femur / Q000648:ultrastructure; D008689:Methacrylates; D008855:Microscopy, Electron, Scanning; D019736:Prostheses and Implants; D011817:Rabbits; D012116:Resins, Plant; D014025:Titanium; D014183:Transplantation, Heterologous / Q000379:methods*
D001672:Biocompatible Materials; D008689:Methacrylates; D012116:Resins, Plant; D014025:Titanium