title: Ceramide-1-phosphate sugars: new types of glycophospholipids.
abstract: Ceramide-1-phosphate sugars were synthesized by direct glycosyl phosphite/phosphate and O-glycosyl trichloroacetimidate/phosphate exchange reactions, respectively. Thus, ceramide-1-O-phosphoric acid 5 gave with sialyl phosphite 1 as sialyl donor directly beta-linked sialyl phosphate 6; deprotection afforded the corresponding glycophospholipid ceramide-1-phosphate N-acetylneuraminate 7. Similarly, from O-glucosyl- and O-galactosyltrichloroacetimidate 10 and 13 with phosphoric acid derivative 5 glycosyl ceramide-1-phosphate sugars 12 and 15, respectively, were obtained.
authors.affiliation: Fakultät Chemie, Universität Konstanz, Germany.
authors.forename: T J
authors.initials: TJ
authors.lastname: Martin
authors.forename: G
authors.initials: G
authors.lastname: Dufner
authors.forename: B
authors.initials: B
authors.lastname: Kratzer
authors.forename: R R
authors.initials: RR
authors.lastname: Schmidt
mesh_terms: D002241:Carbohydrates / Q000737:chemistry*; D002518:Ceramides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010743:Phospholipids / Q000737:chemistry*
chemical_list: D002241:Carbohydrates; D002518:Ceramides; D010743:Phospholipids; C065576:ceramide 1-phosphate