Behavior of long-term dantrolene sodium-treated rat skeletal muscles. Histochemical and electromechanical aspects.
Histochemical and electrochemical studies were carried out on skeletal rat muscles treated with dantrolene sodium (DS) for 60 days. Histochemical experiments revealed a conversion from fast twitch (type II) to slow twitch (type I) fibers for soleus (S), gastrocnemius (GM),a dn extensor digitorum longus (EDL) muscles. However, a significant decrease of muscle contractility was not observed in these chronically treated rat muscles in opposition to both those directly exposed in vitro as the muscles obtained from only 1-h DS-treated animals.
Aoki-Maki
K
K
Departamento Sistemas Biológicas, Universidad Autónoma Metropolitana-Xochimilco, México.
Cortes-Arroyo
A R
AR
Baltazares-Lipp
E
E
D000818:Animals; D003620:Dantrolene / Q000494:pharmacology*; D004594:Electrophysiology; D005260:Female; D006651:Histocytochemistry; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D009125:Muscle Relaxants, Central; D003620:Dantrolene