Pharmacokinetics of lysine clonixinate in children in postoperative care.
The pharmacokinetics of 2 doses of intravenous lysine clonixinate (4 and 6 mg x kg-1) were studied in 10 children (age 4-10 years) under postoperative care. A single dose of the drug was injected in a forearm vein. Blood samples were collected at regular intervals for 3 hours. Serum clonixin concentrations (expressed as clonixin) were analyzed using a high pressure liquid chromatography method. Pharmacokinetic values were estimated by a nonlinear computer program. The distribution volume was similar in both groups of children (1.288 +/- 0.829 1 and 1. 139 +/- 0.667 1, respectively). There were no differences between the values of total plasma clearance and the administered doses (0.026 +/- 0.017 ml x min-1 and 0.017 +/- 0.008 ml x min-1, t = 1.07, p = 0.76). The elimination half-life was longer in children who received 6 mg x kg-1 (44.26 +/- 6.34 min vs 38.63 +/- 10.93 min) but this difference was not statistically significant (t = 0.99, p < 0.34). The pharmacokinetic parameters calculated in these children were different from those found by other authors in adults and experimental animals.
González-Martin
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Department of Pharmacy, Faculty of Chemistry, Pontifical Catholic University of Chile, Santiago, Chile.
Cattan
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C
Zuñiga
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D000367:Age Factors; D000700:Analgesics / Q000493:pharmacokinetics*; D002648:Child; D002675:Child, Preschool; D002677:Chile; D003002:Clonixin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D008297:Male; D010149:Postoperative Pain / Q000188:drug therapy / Q000378:metabolism*
D000700:Analgesics; C089163:lysine clonixinate; D008239:Lysine; D003002:Clonixin