Ability of different flavonoids to inhibit the procoagulant activity of adherent human monocytes.
Sixty-five natural flavonoids of various chemical classes were screened for their ability to inhibit the procoagulant activity of adherent human monocytes stimulated by endotoxin and interleukin-1 beta in vitro. Eighteen of these compounds inhibited the interleukin-1 beta-induced expression of tissue factor on human monocytes, but the most active compound was a biflavonoid: hinokiflavone.
Lale
A
A
Sanofi Recherche, Toulouse, France.
Herbert
J M
JM
Augereau
J M
JM
Billon
M
M
Leconte
M
M
Gleye
J
J
D000595:Amino Acid Sequence; D001777:Blood Coagulation / Q000187:drug effects*; D002448:Cell Adhesion / Q000187:drug effects; D004731:Endotoxins / Q000494:pharmacology; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000494:pharmacology; D008969:Molecular Sequence Data; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism
D004731:Endotoxins; D005419:Flavonoids; D007375:Interleukin-1