Studies on the effect of fenbendazole and mebendazole on some enzymes of swine kidney worm Stephanurus dentatus.
The effect of fenbendazole and mebendazole on the activity of some enzymes of the homogenates of swine kidney worm Stephanurus dentatus was investigated. Fenbendazole at 10(-5) M inhibited malate oxidation by 49% and 51% and oxaloacetate reduction by 33% and 40% whereas, mebendazole at 10(-5) M diminished malate oxidation by 25% and 35% and oxaloacetate reduction by 12% and 14% in male and female S. dentatus, respectively. Lactate dehydrogenase activity was inhibited by 45% and 50% in male and female worm respectively by 10(-5) M fenbendazole. Aldolase activity in both male and female S. dentatus was inhibited by 10(-5) M fenbendazole and mebendazole. Fenbendazole at 10(-5) M caused moderate inhibition of acid and alkaline phosphomonoesterases but mebendazole did not show a significant effect on these enzymes. Cholinesterase activity was not affected significantly with either compound. The possible mode of action of the two compounds is compared.
Singh
K
K
Pest and Parasite Research Laboratory, Postgraduate Department of Zoology, Bareilly College, India.
Kaushal
P
P
D000429:Alcohol Oxidoreductases / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology*; D002802:Cholinesterases / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005273:Fenbendazole / Q000494:pharmacology*; D005634:Fructose-Bisphosphate Aldolase / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D007674:Kidney Diseases / Q000469:parasitology; D008297:Male; D008463:Mebendazole / Q000494:pharmacology*; D010744:Phosphoric Monoester Hydrolases / Q000187:drug effects / Q000378:metabolism; D017206:Strongylida Infections / Q000378:metabolism / Q000662:veterinary*; D013320:Strongyloidea / Q000201:enzymology* / Q000302:isolation & purification; D013552:Swine; D013553:Swine Diseases / Q000469:parasitology*
D000969:Antinematodal Agents; D005273:Fenbendazole; D008463:Mebendazole; D000429:Alcohol Oxidoreductases; D002802:Cholinesterases; D010744:Phosphoric Monoester Hydrolases; D005634:Fructose-Bisphosphate Aldolase