Quantitative measurement of human tissue hepatic blood volume by C15O inhalation with positron-emission tomography.
In order to estimate the tissue liver function, tissue hepatic blood volume was measured quantitatively and non-invasively using C15O inhalation in conjunction with positron-emission tomography. Fifty-eight patients with normal liver function, 14 patients with chronic hepatitis, 28 patients with hepatic cirrhosis, and 4 patients with obstructive jaundice were studied by positron-emission tomography scan after the single breath inhalation of 20 mCi of high specific activity 15O-labeled carbon monoxide. The mean tissue hepatic blood volume was significantly greater in patients with normal livers than in patients with chronic hepatitis or hepatic cirrhosis (mean: 20.5, 18.2, and 16.1 ml per 100 cm3, respectively, p = 8.6 x 10(-8)). Tissue hepatic blood volume (tHBV) correlated with the reaction of the mesenchymal system and protein synthesis, because there was a potent correlation between tHBV and hepatic fibrosis. In normal livers, we were able to demonstrate significant differences in tissue hepatic blood volume among liver segments.
Taniguchi
H
H
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Masuyama
M
M
Koyama
H
H
Oguro
A
A
Takahashi
T
T
D001810:Blood Volume / Q000502:physiology*; D002248:Carbon Monoxide / Q000378:metabolism*; D004396:Coloring Agents / Q000378:metabolism; D005260:Female; D005355:Fibrosis / Q000378:metabolism; D006505:Hepatitis / Q000378:metabolism; D006801:Humans; D007208:Indocyanine Green / Q000378:metabolism; D008111:Liver Function Tests / Q000592:standards; D008297:Male; D008875:Middle Aged; D013223:Statistics as Topic; D014055:Tomography, Emission-Computed
D004396:Coloring Agents; D002248:Carbon Monoxide; D007208:Indocyanine Green