Different levels of sensory neuropeptides (calcitonin gene-related peptide and substance P) during and after exercise in man.
The aim of this study was to investigate the regulation of two sensory peptides calcitonin gene-related peptide (CGRP) and substance P, reflected as circulating levels during provocation of the sympathetic nervous system. Levels in hypertensives, diabetics (NIDDM) and controls were assayed before, during and after an exercise test (average work load carried out was 76 +/- 10 kJ). CGRP levels increased progressively during exercise (P < 0.001), with maximum level at maximum exercise. This was significant in all three groups; hypertensives P < 0.001, diabetics P < 0.01 and controls P < 0.001. No differences in circulating revels of CGRP between the three groups were found. Substance P levels were fairly constant during exercise but increased 30 min after exercise (P < 0.01) in the total group. We hypothesize that CGRP might provide a counter-regulatory mechanism to the sympathetic vasoconstrictor transmitters noradrenaline (NA) and neuropeptide Y (NPY) during sympathetic activation. Substance P did not increase during exercise. This suggests differential regulation and function of the two vasodilatory peptides.
Lind
H
H
Health Sciences Centre, Lund/Dalby, University of Lund, Sweden.
Brudin
L
L
Lindholm
L
L
Edvinsson
L
L
D000328:Adult; D015740:Calcitonin Gene-Related Peptide / Q000097:blood*; D005080:Exercise Test; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D005082:Physical Exertion; D012146:Rest; D013373:Substance P / Q000097:blood*
D013373:Substance P; D015740:Calcitonin Gene-Related Peptide