Impaired cyclic AMP production in the hippocampus of a Down syndrome murine model.
Behavioral and learning disturbances have been found in mice with partial trisomy 16, a new model for Down syndrome. Basal production of cyclic AMP in the hippocampus of trisomic mice was shown to be impaired. In addition, the responses of adenylyl cyclase to the stimulation of beta-adrenoceptors with isoprenaline and of the catalytic subunit with forskolin were both severely depressed.
Dierssen
M
M
Department of Physiology and Pharmacology, University of Cantabria Medical School, Santander, Spain.
Vallina
I F
IF
Baamonde
C
C
Lumbreras
M A
MA
Martínez-Cué
C
C
Calatayud
S G
SG
Flórez
J
J
D015056:1-Methyl-3-isobutylxanthine; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000096:biosynthesis*; D004314:Down Syndrome / Q000378:metabolism*; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D007545:Isoproterenol / Q000494:pharmacology; D051379:Mice; D010726:Phosphodiesterase Inhibitors
D000318:Adrenergic beta-Agonists; D010726:Phosphodiesterase Inhibitors; D005576:Colforsin; D000242:Cyclic AMP; D007545:Isoproterenol; D015056:1-Methyl-3-isobutylxanthine