Abnormalities in secondary cartilages in four lines of transgenic mice harboring two different types of mutations in the cartilage-specific type II collagen gene.
A histological analysis was performed on two secondary cartilages, the mandibular condyle and the medial end of clavicle, in transgenic mice harboring two different types of mutations in the cartilage-specific type II collagen gene. Considerable differences were observed in the maturation zone of the chondrocytes and the hypertrophic cells of the growth regions of the two secondary cartilages examined between the transgenic mice and their transgene-negative littermates, which served as controls. Looseness of the perichondrium/periosteum was a distinct feature seen in both mutations. However, phenotypic consequences of the mutations in secondary cartilages were less severe than those in primary cartilages. We propose that the differences between primary and secondary cartilages are due to differences in their origin, mode of growth, architecture and behavior under extrinsic factors.
Rintala
M
M
Institute of Dentistry, University of Turku, Finland.
Metsäranta
M
M
Vuorio
E
E
Rönning
O
O
D000595:Amino Acid Sequence; D000818:Animals; D002356:Cartilage / Q000002:abnormalities* / Q000473:pathology; D002968:Clavicle / Q000002:abnormalities*; D003094:Collagen / Q000235:genetics*; D018628:Gene Dosage; D005796:Genes / Q000235:genetics; D008335:Mandibular Condyle / Q000002:abnormalities*; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D009154:Mutation; D012333:RNA, Messenger / Q000032:analysis
D012333:RNA, Messenger; D003094:Collagen