Premenopause-dependent changes.
The authors retrospectively evaluated 1,773 climacteric outpatients in order to establish: (a) criteria able to distinguish different conditions in the transitional phase before menopause (advanced fertile age and premenopause) and (b) premenopause-related changes during the transition from one to the other of several clinical and laboratory parameters. Results showed an increase in gonadotropin plasma levels, a decrease in estrogen plasma levels and a greater frequency of women complaining of hot flushes in premenopause compared to advanced fertile age, as an expression of the progressive decline of ovarian function. Premenopause-related changes were a decrease in thyroid function and an increase in the body mass index, the beginning of bone loss, an increase in glucose, total cholesterol and triglyceride serum levels and a greater frequency of women complaining of hypertension and urinary stress incontinence. An increase in total proteins, uric acid and aminotransferase serum levels was also noted.
de Aloysio
D
D
Department of Obstetrics and Gynecology, University of Bologna, Italy.
Altieri
P
P
Penacchioni
P
P
Mauloni
M
M
Bottiglioni
F
F
D000328:Adult; D000375:Aging / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D001842:Bone and Bones / Q000378:metabolism; D002979:Climacteric / Q000502:physiology; D015331:Cohort Studies; D004573:Electrolytes / Q000097:blood / Q000652:urine; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D050356:Lipid Metabolism; D008875:Middle Aged; D017697:Premenopause / Q000502:physiology*; D012189:Retrospective Studies; D013963:Thyroid Hormones / Q000097:blood; D014550:Urinary Incontinence, Stress / Q000503:physiopathology
D001786:Blood Glucose; D004573:Electrolytes; D012739:Gonadal Steroid Hormones; D006065:Gonadotropins, Pituitary; D013963:Thyroid Hormones