title: Antisense oligonucleotides as inhibitors of signal transduction: development from research tools to therapeutic agents.
authors.affiliation: Department of Molecular Pharmacology, ISIS Pharmaceuticals, Carlsbad, CA 92008, USA.
authors.forename: N M
authors.initials: NM
authors.lastname: Dean
authors.forename: R
authors.initials: R
authors.lastname: McKay
authors.forename: L
authors.initials: L
authors.lastname: Miraglia
authors.forename: T
authors.initials: T
authors.lastname: Geiger
authors.forename: M
authors.initials: M
authors.lastname: Müller
authors.forename: D
authors.initials: D
authors.lastname: Fabbro
authors.forename: C F
authors.initials: CF
authors.lastname: Bennett
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D046508:Culture Techniques; D018390:Gene Targeting; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D016376:Oligonucleotides, Antisense / Q000235:genetics / Q000493:pharmacokinetics / Q000494:pharmacology*; D011493:Protein Kinase C / Q000235:genetics; D051571:Protein Kinase C-alpha; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics; D019908:Proto-Oncogene Proteins c-raf; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects* / Q000235:genetics
chemical_list: D007527:Isoenzymes; D016376:Oligonucleotides, Antisense; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D017346:Protein Serine-Threonine Kinases; D019908:Proto-Oncogene Proteins c-raf; C496628:PRKCA protein, human; D011493:Protein Kinase C; D051571:Protein Kinase C-alpha