Apolipoprotein E in neurology.
Apolipoprotein E became relevant for neurologists in 1993 when the association of the apolipoprotein E-epsilon 4 allele with familial and sporadic late-onset Alzheimer disease was reported. Since that time, more than 100 confirmations and many research papers have appeared. A large neurobiological literature concerning the role of apolipoprotein E in the metabolism of the central nervous system is developing.
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Alzheimer's Disease Research Center, Department of Medicine (Neurology), Duke University Medical Center, Durham, North Carolina 27110-2900, USA.
D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics*; D000818:Animals; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001921:Brain / Q000473:pathology; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D016874:Neurofibrillary Tangles / Q000473:pathology; D012307:Risk Factors
D053327:Apolipoprotein E4; D001057:Apolipoproteins E