title: Injection pain with propofol. Reduction with aspiration of blood.
abstract: A randomised, controlled, single-blind study was performed on 100 patients to investigate a new method of reducing pain on propofol injection. Aspiration of 2 ml of the patient's blood into a syringe of propofol immediately before injection was compared with the addition of lignocaine 20 mg or normal saline 2 ml to the propofol before injection. The addition of blood was significantly more effective in reducing pain on injection than the addition of saline (p < 0.001), but was not significantly more effective than the addition of lignocaine.
authors.affiliation: Department of Anaesthesia, St. George's Hospital, London.
authors.forename: D S
authors.initials: DS
authors.lastname: McDonald
authors.forename: P
authors.initials: P
authors.lastname: Jameson
mesh_terms: D000328:Adult; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D018962:Phlebotomy; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects*; D016037:Single-Blind Method
chemical_list: D018686:Anesthetics, Intravenous; D008012:Lidocaine; D015742:Propofol