Dopaminergic regulation of postnatal development of dynorphin neurons in rat striatum.
This study examined whether the postnatal development of the biosynthesis of an opioid peptide, dynorphin A (1-8) (DYN) is influenced by dopamine (DA) deficiency. The neurotoxin 6-hydroxydopamine (6-OHDA) was used as a tool to induce DA deficiency on the third day of the postnatal period in Sprague-Dawley rat pups. During the postnatal period, the levels of striatal DYN steadily increased in an age-dependent fashion and appeared to peak between 35 and 45 days. In neonatal 6-OHDA-lesioned animals, the category with 95% or more DA loss exhibited a reduction in the levels of DYN in the postnatal period whereas the category with less than 95% DA loss did not show significant changes in DYN levels. The results indicate that the normal development of striatal DYN is negatively affected only when there is a near-total loss of DA during early postnatal period.
Sivam
S P
SP
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Gary 46408, USA.
D000818:Animals; D000831:Animals, Newborn; D002851:Chromatography, High Pressure Liquid; D003714:Denervation; D004298:Dopamine / Q000502:physiology*; D004399:Dynorphins / Q000502:physiology*; D005260:Female; D017072:Neostriatum / Q000166:cytology* / Q000254:growth & development* / Q000378:metabolism; D009474:Neurons / Q000502:physiology*; D016627:Oxidopamine / Q000494:pharmacology; D011247:Pregnancy; D011863:Radioimmunoassay; D051381:Rats; D017207:Rats, Sprague-Dawley; D013565:Sympatholytics / Q000494:pharmacology
D013565:Sympatholytics; D004399:Dynorphins; D016627:Oxidopamine; D004298:Dopamine