[The effect of prostaglandin E1 on body temperature, catecholamines and stress hormones during prolonged surgery].
The effects of prostaglandin E1 (PGE1) on body temperature, catecholamines and stress hormones were evaluated in 10 patients undergoing elective prolonged surgery over 12 hours. PGE1 (0.03 microgram.kg-1.min-1) was administered in 5 patients and was not administered in 5 patients. Deep skin-surface temperature gradients were 5.1 +/- 2.3 degrees C in PGE1 non-administered group and 0.8 +/- 0.9 degree C in PGE1 administered group (P < 0.05). Pharyngeal-skin surface temperature gradients were 8.8 +/- 2.1 degrees C in PGE1 non-administered group and 1.5 +/- 1.5 degrees C in PGE1 administered group (P < 0.05). There were no significant differences between the two groups in respects to catecholamines, stress hormones, lactate level and blood sugar. PGE1 0.03 microgram.kg-1.min-1 is effective in maintaining peripheral circulation without causing body temperature changes during prolonged surgery.
Okuda
M
M
Department of Anesthesiology, Mie University School of Medicine, Tsu.
Amano
H
H
Furuhashi
K
K
Nakai
Y
Y
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000527:Alprostadil / Q000494:pharmacology*; D000768:Anesthesia, General; D000804:Angiotensin II / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001831:Body Temperature / Q000187:drug effects*; D002395:Catecholamines / Q000097:blood*; D017558:Elective Surgical Procedures; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008875:Middle Aged; D012083:Renin / Q000097:blood
D001786:Blood Glucose; D002395:Catecholamines; D000804:Angiotensin II; D000324:Adrenocorticotropic Hormone; D012083:Renin; D000527:Alprostadil; D006854:Hydrocortisone