title: Ischemic neuronal damage. How does mild hypothermia modulate it?
abstract: The significance of mild hypothermia as a therapeutic measure for ischemic brain damage is presented on the basis of different experimental results. An extracellular glutamate surge, a sustained activation of N-methyl-D-aspartate (NMDA) receptors, and an enhancement of DNA binding activity to transcription factor AP-1, all being key items directly linked to excitotoxic neuronal damage, are deeply affected by slightly lowering temperature (mild hypothermia [MH]). The cellular mechanism of MH seems rather nonspecific but tends to collectively involve these key items rendering neurons resistant to ischemic damage. Clinical application of MH should be a great challenge to relieve deadly effects on central neurons.
authors.affiliation: Department of Physiology, Ehime University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kataoka
authors.forename: A
authors.initials: A
authors.lastname: Mitani
authors.forename: H
authors.initials: H
authors.lastname: Yanase
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Higashihara
authors.forename: T
authors.initials: T
authors.lastname: Ogata
authors.forename: K
authors.initials: K
authors.lastname: Tsuji
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: A
authors.initials: A
authors.lastname: McRae
authors.forename: K
authors.initials: K
authors.lastname: Ogita
authors.forename: Y
authors.initials: Y
authors.lastname: Yoneda
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology / Q000502:physiology / Q000503:physiopathology*; D002545:Brain Ischemia / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy*; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D007036:Hypothermia, Induced; D009474:Neurons / Q000473:pathology* / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D018808:Transcription Factor AP-1 / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D016194:Receptors, N-Methyl-D-Aspartate; D018808:Transcription Factor AP-1; D018698:Glutamic Acid; D004247:DNA