Correlation of in vivo infectivity of hepatitis C virus to in vitro infectivity and to virion properties.
Serum from an individual who was chronically infected with hepatitis C virus (HCV) was inoculated into chimpanzees and a human T cell line. The serum contained a quasispecies population of HCV consisting of at least six genetic sequences. However, only two sequences (the same two sequences) were recovered both in chimpanzees and in cultured human T cell line, indicating that infection of the culture system reflects infection in vivo.
Yoshikura
H
H
Department of Bacteriology, School of Medicine, University of Tokyo, Japan.
Hijikata
M
M
Nakajima
N
N
Wang
M
M
Mizuno
K
K
Rikihisa
T
T
Ueno
T
T
Nishimura
S
S
Shimizu
Y
Y
D000595:Amino Acid Sequence; D000818:Animals; D016174:Hepacivirus / Q000472:pathogenicity*; D006801:Humans; D008969:Molecular Sequence Data; D002679:Pan troglodytes; D014771:Virion / Q000472:pathogenicity*; D014779:Virus Replication