The rationale and ultimate limitations of urea kinetic modelling in the estimation of nutritional status.
OBJECTIVE
This paper reviews protein flux and amino acid metabolism and the potential inaccuracies inherent in using urea kinetics as an estimate of these processes, particularly in the patient undergoing peritoneal dialysis. The problems of extrapolating these estimates back to the whole patient are examined, addressing assumptions about neutral nitrogen balance, and the difficult issue of normalizing urea-derived indices to body size.


CONCLUSIONS
Urea kinetics can be a helpful tool for assessing nutritional indices, but there are many caveats and many pitfalls that must be kept in mind to avoid being lulled into a false sense of confidence by the comfort of numbers.
Bargman
J M
JM
Department of Medicine, University of Toronto, Ontario, Canada.
D000596:Amino Acids / Q000378:metabolism; D004044:Dietary Proteins / Q000008:administration & dosage; D006801:Humans; D009752:Nutritional Status; D010531:Peritoneal Dialysis, Continuous Ambulatory; D014508:Urea / Q000378:metabolism*
D000596:Amino Acids; D004044:Dietary Proteins; D014508:Urea