title: Responses of somatostatin, beta-endorphin and dynorphin A to a glucose load in two groups of women with polycystic ovarian syndrome.
abstract: To investigate the relationship between elevated LH, hyperinsulinemia and neuropeptides in polycystic ovarian syndrome (PCOS), we measured the endogenous levels of insulin, somatostatin (SS), beta-endorphin (beta-EP) and dynorphin A (Dyn A) before and after a glucose load in three groups: group 1 (LH/ FSH > or = 3, n = 30); group 2 (LH/FSH < 3, n = 25), and controls (n = 15). In the basal state, significantly negative correlations were found between LH and SS (r = -0.51, p < 0.05) in group 1 and between LH and beta-EP (r = -0.49, p < 0.05) in group 2. After a glucose load, PCOS women had greater beta-EP and Dyn A responses in group 1 and impaired SS response in group 2 as compared with the control. The data suggest endogenously lower SS, higher beta-EP and Dyn A may contribute to the elevation of LH and insulin secretions in PCOS.
authors.affiliation: Department of Gynecology, Nanjing Jingling Hospital, People's Republic of China.
authors.forename: X K
authors.initials: XK
authors.lastname: Wu
authors.forename: C H
authors.initials: CH
authors.lastname: Wang
authors.forename: Y H
authors.initials: YH
authors.lastname: Su
mesh_terms: D000328:Adult; D002404:Catheterization; D002408:Catheters, Indwelling; D015331:Cohort Studies; D004399:Dynorphins / Q000097:blood / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000378:metabolism* / Q000503:physiopathology; D012016:Reference Values; D013004:Somatostatin / Q000097:blood / Q000378:metabolism*; D013997:Time Factors; D001615:beta-Endorphin / Q000097:blood / Q000378:metabolism*
chemical_list: D007328:Insulin; D013004:Somatostatin; D001615:beta-Endorphin; D004399:Dynorphins; D007986:Luteinizing Hormone; D005947:Glucose