Treatment of HIV associated psoriatic arthritis with oral gold.
We report a patient with human immunodeficiency virus (HIV) infection and disabling psoriatic arthritis who was treated with auranofin. Her skin lesions and arthritis resolved after auranofin treatment and she has remained free of opportunistic infections during 24 mo followup. Her CD4 count during oral gold therapy showed a significant, sustained increase in CD4 cells. The literature on the effect of gold compounds on HIV infectivity and HIV reverse transcriptase is reviewed.
Department of Medicine, Elmhurst Hospital Center, NY, USA.
D L
DL
Shapiro
J R
JR
Masci
D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D015535:Arthritis, Psoriatic / Q000150:complications / Q000188:drug therapy*; D001310:Auranofin / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications*; D006801:Humans
D018501:Antirheumatic Agents; D001310:Auranofin