Advances in clinical pharmacology and therapeutics: endothelin.
Endothelin-1, a potent endothelium-derived 21-amino acid vasoconstrictor peptide was only discovered relatively recently. Antagonism of its actions may provide an important new approach to the modulation of cardiac and vascular function.
Newby
D E
DE
University Department of Medicine, Western General Hospital, Edinburgh.
Webb
D J
DJ
D000818:Animals; D002318:Cardiovascular Diseases / Q000503:physiopathology; D065128:Endothelin Receptor Antagonists; D019332:Endothelin-1 / Q000502:physiology; D016232:Endothelins / Q000037:antagonists & inhibitors / Q000502:physiology*; D006801:Humans; D051437:Renal Insufficiency / Q000503:physiopathology
D065128:Endothelin Receptor Antagonists; D019332:Endothelin-1; D016232:Endothelins