Functional diversity of helper T lymphocytes.
The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal and pathological immune responses. Defining the cellular and molecular mechanisms of helper-T-cell differentiation should lead to rational strategies for manipulating immune responses for prophylaxis and therapy.
Abbas
A K
AK
Immunology Research Division, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Murphy
K M
KM
Sher
A
A
D000818:Animals; D015551:Autoimmunity / Q000276:immunology; D002454:Cell Differentiation / Q000235:genetics; D016207:Cytokines / Q000096:biosynthesis; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007239:Infections / Q000276:immunology; D017634:Self Tolerance / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000276:immunology*
D016207:Cytokines