Association of primary renal non-Hodgkin's lymphoma with mesangioproliferative glomerulonephritis.
A 27-year-old male developed nonoliguric renal failure. Renal biopsy of the left kidney showed infiltration by a diffuse large-cell non-Hodgkin's lymphoma (NHL). Laparoscopy, CT scans of the abdomen and thorax, and bone-marrow biopsy revealed no further manifestations of lymphoma. Primary renal NHL was diagnosed. The patient attained complete remission with cyclophosphamide, adriamycin, vincristine, and prednisone (CHOP) chemotherapy and remained disease-free for 13 years. Eight years after his first presentation, the patient developed acute oliguric renal failure with nephrotic syndrome. Mesangioproliferative glomerulonephritis was diagnosed in a biopsy of the left kidney. Chronic hemodialysis was required until cadaver kidney transplantation was successfully performed 5 years later. Although the association of NHL and glomerulonephritis has been described several times before, to our knowledge this is the first report of glomerulonephritis in primary renal lymphoma.
Division of Hematology/Oncology, Heinrich-Heine University, Dusseldorf, Germany.
J
J
Zahner
C D
CD
Gerharz
D
D
Bach
A
A
Heer-Sonderhoff
M
M
Winkelmann
B
B
Grabensee
W
W
Schneider
D000328:Adult; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications* / Q000473:pathology; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications* / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000473:pathology; D008297:Male