Effect of ginseng radix on GLUT2 protein content in mouse liver in normal and epinephrine-induced hyperglycemic mice.
The oral administration of the water extract of Ginseng Radix (GR) to normal and epinephrine-induced hyperglycemic mice caused a significant decrease in the blood glucose level 4 h after its administration. The hepatic content of facilitative glucose transporter isoform 2, liver type glucose transporter (GLUT2) protein content from mouse liver significantly increased in the orally GR-treated normal and epinephrine-induced hyperglycemic mice compared to that in the controls. These results suggest that the hypoglycemic activity of GR is presumably due, at least in part, to the increment of GLUT2 protein content.
Ohnishi
Y
Y
Department of Clinical Nutrition, Suzuka University of Medical Science and Technology, Faculty of Health Science, Mie, Japan.
Takagi
S
S
Miura
T
T
Usami
M
M
Kako
M
M
Ishihara
E
E
Yano
H
H
Tanigawa
K
K
Seino
Y
Y
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D015153:Blotting, Western; D004837:Epinephrine; D051273:Glucose Transporter Type 2; D006943:Hyperglycemia / Q000139:chemically induced / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009004:Monosaccharide Transport Proteins / Q000378:metabolism*; D005894:Panax; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal
D001786:Blood Glucose; D051273:Glucose Transporter Type 2; D009004:Monosaccharide Transport Proteins; D010936:Plant Extracts; D004837:Epinephrine