Heterogeneity, biodiversity and bioperversity in solid neoplasms.
Heterogeneity of biological structure and function is an impediment to the analysis and treatment of human solid tumours. Its importance is frequently underestimated in clinico-pathological research. This article reviews the many facets of heterogeneity in tumour systems, and its importance to the interpretation of tumour biology.
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University Surgical Unit, Glenfield Hospital, Leicester, UK.
D002455:Cell Division; D019008:Drug Resistance, Neoplasm; D005838:Genotype; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D009369:Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy