Glutamine metabolism of intestine grafts: influence of mucosal injury by prolonged preservation and transplantation.
The demand for glutamine increased only in the preserved intestine in the early postoperative period (3 days after transplantation). Glutamine demand of the preserved grafts returned to control and immediate levels 7 and 14 days after transplantation. Three days after intestinal transplantation, when the intestinal mucosa was actively regenerating, the demand for glutamine was markedly enhanced. The enhanced demand for glutamine was met by increased output of glutamine by the liver and skeletal muscle. Glutamine uptake by the intestinal graft was enhanced by a brief infusion of glutamine. Thus, we believe exogenous glutamine supplementation may be beneficial for the recovery of intestinal grafts with severe mucosal injury.
Pittsburgh Transplantation Institute, University of Pittsburgh, Pennsylvania, USA.
A
A
Nemoto
A
A
Krajack
T
T
Suzuki
I
I
Takeyoshi
N
N
Hamada
M
M
Nomoto
S
S
Zhang
Y
Y
Zhu
T E
TE
Starzl
S
S
Todo
D000818:Animals; D004285:Dogs; D005260:Female; D005973:Glutamine / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics; D007262:Infusions, Intravenous; D007413:Intestinal Mucosa / Q000473:pathology / Q000502:physiology* / Q000637:transplantation*; D007421:Intestine, Small / Q000473:pathology / Q000502:physiology / Q000637:transplantation*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D009926:Organ Preservation / Q000009:adverse effects*; D010289:Parenteral Nutrition, Total; D012016:Reference Values; D014184:Transplantation, Homologous / Q000473:pathology / Q000502:physiology*
D005973:Glutamine