[Glycosylphosphatidylinositol-anchored proteins with complement-regulatory activity on erythrocytes].
Decay-accelerating factor (DAF) and CD59 are major complement regulators linked to plasma membrane via glycosylphosphatidylinositol anchor and inhibit C3 activation and the formation of membrane attack complex, respectively. These factors have been shown to protect human erythrocytes from the lytic action of autologous complement. Here we overview structure and function of these molecules, and discuss about their physiological roles in controlling the complement activation, ie, defining the susceptibility of erythrocytes to complement.
Second Department of Internal Medicine, Kumamoto University School of Medicine.
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T
Kawaguchi
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H
Nakakuma
D018958:CD55 Antigens / Q000502:physiology; D018957:CD59 Antigens / Q000502:physiology; D003167:Complement Activation; D015938:Complement Membrane Attack Complex / Q000502:physiology; D004912:Erythrocytes / Q000276:immunology*; D017261:Glycosylphosphatidylinositols / Q000502:physiology*; D006801:Humans
D018958:CD55 Antigens; D018957:CD59 Antigens; D015938:Complement Membrane Attack Complex; D017261:Glycosylphosphatidylinositols