Chimerism and central tolerance.
With adequate depletion or inactivation of the pre-existing immune system and establishment of conditions permitting donor hematopoietic stem cell engraftment, a robust state of central deletional tolerance to allogeneic or xenogeneic donors can be induced. Advances have been made in the ability to achieve this permissive state without toxic, myeloablative conditioning, thus bringing this approach closer to clinical application.
Bone Marrow Transplantation Section, Massachusetts General Hospital East, Boston 02129, USA. sykes@helix.mgh.harvard.edu
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D000818:Animals; D002678:Chimera / Q000276:immunology*; D006085:Graft Survival / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007108:Immune Tolerance; D008212:Lymphocyte Depletion; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology / Q000637:transplantation; D019172:Transplantation Conditioning; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous