The effects of peripheral serotonin2 (5-HT2) and serotonin3 (5-HT3) receptor agonists on blood glucose levels in rats.
The involvement of the peripheral serotonin2A (5-HT2A) receptor in alpha-methyl-5-HT-induced hyperglycemia was examined in rats. The 5-HT2A receptor antagonist, ketanserin, significantly inhibited alpha-methyl-5-HT-elicited hyperglycemia. Taken together with a previous report that 5-HT-induced hyperglycemia was prevented by ketanserin, it is suggested that the peripheral 5-HT2A receptor participates in glucose regulation. As alpha-methyl-5-HT increased serum insulin but did not affect glucagon levels, it is indicated that these pancreatic hormones are probably not related to alpha-methyl-5-HT-induced hyperglycemia. Moreover, the peripheral 5-HT3 receptor agonist, 2-methyl-5-HT, did not affect blood glucose, insulin or glucagon levels. Our results therefore suggest that the peripheral 5-HT3 receptor is not involved in glucose regulation.
Department of Pharmacology, Kobe Pharmaceutical University, Japan.
Y
Y
Sugimoto
J
J
Yamada
T
T
Yoshikawa
K
K
Horisaka
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D005934:Glucagon / Q000097:blood; D007328:Insulin / Q000097:blood; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D001786:Blood Glucose; D007328:Insulin; D017366:Serotonin Receptor Agonists; D012701:Serotonin; C045918:2-methyl-5-HT; D005934:Glucagon; D007650:Ketanserin