Abnormalities in adenosine triphosphatase of the erythrocyte membrane in iron deficiency anaemia.
During iron deficiency rat and human erythrocyte membrane enzyme activities (Total ATPase and Ouabainsensitive Na+.K+ ATPase) showed significant (P < 0.001) decrease. The influence of iron deficiency on erythrocyte Na+ and K+ was also studied in rats and humans. The former parameter showed a significant (P < 0.01) increase while the latter showed a downward trend. Plasma Fe and Total Iron Binding capacity (TIBC) in iron deficiency varied significantly (P < 0.05) from normal values. These results suggest a defect in erythrocyte membrane function and a possible potentiating effect of intracellular Na+, plasma Fe and TIBC on ATPase activity in iron deficiency. Values obtained for rats and humans showed differences in the activities of membrane ATPase in iron deficiency anaemia.
Ifere
G O
GO
Department of Chemical Sciences, Polytechnic, Calabar, Nigeria.
Ifon
E T
ET
Ebong
P E
PE
Umoh
I B
IB
D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000201:enzymology*; D000818:Animals; D004910:Erythrocyte Membrane / Q000201:enzymology*; D006801:Humans; D011188:Potassium / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000097:blood; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium