Base-modification mRNA editing through deamination--the good, the bad and the unregulated.
RNA editing is a co- or post-transcriptional process in which select nucleotide sequences in RNA are altered from that originally encoded in the genome. The mRNAs encoding apolipoprotein B and some glutamate receptor subunits of ionotropic membrane channels are edited by site-specific base-deamination systems. Although these editing systems differ markedly in their mechanism for RNA-substrate binding and in their catalytic subunits, recent results suggest potentially common solutions to the problem of editing-site selectivity. The data suggest that there are multiple editing complexes or 'editosomes', which manifest editing-site preferences due to their macromolecular composition.
Smith
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HC
Department of Pathology, University of Rochester, NY 14642, USA. hsmith@pathology.rochester.edu
Sowden
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MP
D000595:Amino Acid Sequence; D000818:Animals; D001055:Apolipoproteins B / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics; D001483:Base Sequence; D016384:Consensus Sequence; D003564:Cytidine Deaminase / Q000737:chemistry / Q000235:genetics; D003844:DCMP Deaminase / Q000737:chemistry / Q000235:genetics; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D005786:Gene Expression Regulation; D005966:Glucuronidase / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D008322:Mammals; D017393:RNA Editing; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism
D001055:Apolipoproteins B; D012333:RNA, Messenger; D005966:Glucuronidase; D003844:DCMP Deaminase; D003564:Cytidine Deaminase