Placental pathology of triploidy.
Triploidy is a common chromosome abnormality in spontaneous abortions. Previous studies of spontaneous abortions have suggested that approximately 85% of triploid abortuses show the placental changes of partial hydatidiform mole (PHM) and that this appearance was associated, possibly attributable, to paternal origin of the extra haploid set of chromosomes. More recent work, however, has shown that most triploidy is the result of digyny--the extra set of chromosomes originating from the mother. Given the association of PHM with diandry, these results would appear to be at odds with the results of previous studies of placental morphology in triploids. The authors reviewed the placental pathology of all cases of triploidy examined at their institution over a 2-year period and established that PHM occurs in a minority of triploid conceptuses. These results support the findings of studies showing that digyny is the most common origin of triploidy.
McFadden
D E
DE
Department of Pathology, British Columbia's Children's Hospital, Vancouver.
Pantzar
J T
JT
D000022:Abortion, Spontaneous / Q000235:genetics; D000328:Adult; D015509:Developmental Biology; D005314:Embryonic and Fetal Development / Q000235:genetics; D005260:Female; D005865:Gestational Age; D006801:Humans; D006828:Hydatidiform Mole / Q000235:genetics* / Q000473:pathology*; D010920:Placenta / Q000473:pathology*; D011247:Pregnancy; D012189:Retrospective Studies; D014314:Trisomy / Q000235:genetics*; D014594:Uterine Neoplasms / Q000235:genetics / Q000473:pathology*