Growth of Chlamydia pneumoniae induces cytokine production and expression of CD14 in a human monocytic cell line.
Chlamydia pneumoniae was able to survive and to multiply in the human monocytic cell line Mono Mac 6. Growth of C. pneumoniae induced production of tumor necrosis factor alpha, interleukin 1beta, and interleukin 6, as well as up-regulation of the CD14 molecule in a time-dependent manner. Infection of monocytic cells and a proinflammatory cytokine response may be important in C. pneumoniae pathogenesis.
Abteilung für Medizinische Mikrobiologie und Hygiene, Universitat Ulm,Germany.
M
M
Heinemann
M
M
Susa
U
U
Simnacher
R
R
Marre
A
A
Essig
D002460:Cell Line; D016993:Chlamydophila pneumoniae / Q000254:growth & development*; D016207:Cytokines / Q000096:biosynthesis*; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D018950:Lipopolysaccharide Receptors / Q000096:biosynthesis*; D008854:Microscopy, Electron; D009000:Monocytes / Q000276:immunology / Q000382:microbiology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D015854:Up-Regulation
D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D018950:Lipopolysaccharide Receptors; D014409:Tumor Necrosis Factor-alpha