Genetic fitness in Huntington's Disease and Spinocerebellar Ataxia 1: a population genetics model for CAG repeat expansions.
An analysis of genetic fitness was performed in Huntington's Disease (HD) and Spinocerebellar Ataxia 1 (SCA1) families. Two partially overlapping samples were used: clinically defined HD and SCA1 patients from families ascertained in definite geographical areas, and molecularly typed carriers of HD and SCA1 mutations (CAG trinucleotide expansions). In both cases, a control group of normal relatives was used. HD and SCA1 patients born before 1915-20 had more children than normal controls. Carriers of HD and SCA1 mutations, all in the low/medium expansion range (37-49 and 47-54 CAG repeats respectively), had a higher number of children than controls up to more recent times (1935-1950). The reproduction of heterozygotes for large expansions could be analysed only in subjects born after 1950 and provided indirect evidence of a lower than normal number of children. The above results fit a model based on a differential fitness according to the degree of expansion. Such a model predicts that 1) up to relatively recently the frequency of alleles in the low/medium range has been maintained or even increased by the increased fitness of their carriers, as well as by new mutations, and 2) the frequency of large expansions, part of which are lost at each generation, is maintained through further expansions of alleles in the low/medium expansion range. The implications of such a model on linkage disequilibrium and the possible spread of these diseases in future generations are discussed.
Frontali
M
M
Istituto di Medicina Sperimentale del CNR, Rome, Italy. fronta@biocell.irmkant.rm.cnr.it
Sabbadini
G
G
Novelletto
A
A
Jodice
C
C
Naso
F
F
Spadaro
M
M
Giunti
P
P
Jacopini
A G
AG
Veneziano
L
L
Mantuano
E
E
Malaspina
P
P
Ulizzi
L
L
Brice
A
A
Durr
A
A
Terrenato
L
L
D017668:Age of Onset; D005191:Family Characteristics; D005260:Female; D006579:Heterozygote; D006801:Humans; D006816:Huntington Disease / Q000235:genetics* / Q000401:mortality; D015810:Linkage Disequilibrium; D008297:Male; D008957:Models, Genetic; D013132:Spinocerebellar Degenerations / Q000235:genetics* / Q000401:mortality; D013997:Time Factors; D018911:Trinucleotide Repeats