Diltiazem improves left ventricular systolic function following acute myocardial infarction treated with streptokinase. The Calcium Antagonist in Reperfusion Study (CARES) Group.
The role of diltiazem on left ventricular systolic function was analyzed in 101 patients with acute myocardial infarction treated with streptokinase, being obtained, for the total of the population, higher LV global ejection fraction (p = 0.022), LV regional shortening (p = 0.046) and LV global shortening (p = 0.064) for the treated group, relative to the placebo group; the p values were, respectively, 0.005, 0.009, and 0.012, for patients that achieved TIMI-3 antegrade coronary flow. It is concluded that diltiazem is useful as adjuvant to streptokinase, especially when antegrade coronary blood flow TIMI-3 is obtained.
Nicolau
J C
JC
Instituto de Moléstias Cardiovasculares, Sao José do Rio Preto, Brazil.
Ramires
J A
JA
Maggioni
A P
AP
Garzon
S A
SA
Pinto
M A
MA
Silva
D G
DG
Nogueira
P R
PR
Maia
L F
LF
Vendramini
P
P
Bassi
I
I
D000368:Aged; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004110:Diltiazem / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology*; D011446:Prospective Studies; D013300:Streptokinase / Q000627:therapeutic use*; D013599:Systole / Q000187:drug effects; D015912:Thrombolytic Therapy; D013997:Time Factors; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000187:drug effects*
D002121:Calcium Channel Blockers; D005343:Fibrinolytic Agents; D013300:Streptokinase; D004110:Diltiazem