Effect of antireflux medication on salivary drooling in children with cerebral palsy.
Salivary drooling is a common and debilitating problem in cerebral palsy (CP). We hypothesised that gastro-oesophageal reflux (GOR) may exacerbate drooling by stimulation of the oesophago-salivary reflex. The aim of our study was to assess the role of GOR in children with CP and severe drooling. Twenty-four children with CP and severe drooling underwent oesophageal pH monitoring (N = 23) or oesophagoscopy (N = 1). Nine had pathological GOR and were enrolled in a double blinded, placebo controlled cross-over trial of medical antireflux therapy (ranitidine plus cisapride) versus placebo. Drooling was measured by semi-quantitative observation (drooling quotient) and a questionnaire-based scoring system (rated by the child's caregivers). Mean drooling quotients and scores for drooling severity and frequency were not significantly different between active medication and placebo. In our study, treatment of pathological GOR did not improve salivary drooling in children with CP.
Heine
R G
RG
Department of Gastroenterology, Royal Children's Hospital, Parkville, Victoria, Melbourne, Australia.
Catto-Smith
A G
AG
Reddihough
D S
DS
D000293:Adolescent; D002547:Cerebral Palsy / Q000150:complications* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D020117:Cisapride; D004947:Esophagus / Q000503:physiopathology; D005260:Female; D005764:Gastroesophageal Reflux / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D010277:Parasympathomimetics / Q000494:pharmacology* / Q000627:therapeutic use; D010880:Piperidines / Q000494:pharmacology* / Q000627:therapeutic use; D011899:Ranitidine / Q000494:pharmacology* / Q000627:therapeutic use; D012472:Salivation / Q000187:drug effects*; D012720:Severity of Illness Index; D012798:Sialorrhea / Q000209:etiology* / Q000503:physiopathology
D006635:Histamine H2 Antagonists; D010277:Parasympathomimetics; D010880:Piperidines; D011899:Ranitidine; D020117:Cisapride