Bone scans in neurofibromatosis: neurofibroma, plexiform neuroma and neurofibrosarcoma.
Neurofibromatosis type 1 or von Recklinghausen's disease is one of the most common autosomal dominant genetic disorders. Between 29% and 77% of patients may suffer from a wide range of skeletal abnormalities and, thus, patients with neurofibromatosis frequently undergo skeletal scintigraphy, at which time the common peripheral nerve soft-tissue tumors that occur in this syndrome (neurofibromas, plexiform neuromas and neurofibrosarcomas) may be demonstrated.


METHODS
Single or multiphase 99mTc methylenediphosphonate (MDP) bone scans were performed in five patients with neurofibromatosis as part of their clinical evaluation.


RESULTS
We imaged neurofibrosarcomas in three patients, cutaneous neurofibromas in one patient and a plexiform neuroma in one patient.


CONCLUSIONS
Single- or multiphasic bone scans may localize common soft-tissue tumors in neurofibromatosis.
Department of Internal Medicine, University of Michigan, Ann Arbor, USA.
R T
RT
Kloos
V
V
Rufini
M D
MD
Gross
B
B
Shapiro
D000328:Adult; D001847:Bone Diseases / Q000150:complications / Q000000981:diagnostic imaging*; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009455:Neurofibroma / Q000000981:diagnostic imaging*; D018318:Neurofibroma, Plexiform / Q000000981:diagnostic imaging; D009456:Neurofibromatosis 1 / Q000150:complications / Q000000981:diagnostic imaging*; D018319:Neurofibrosarcoma / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging*; D013669:Technetium Tc 99m Medronate
D013669:Technetium Tc 99m Medronate