Graves'disease after the onset of panic disorder.
BACKGROUND
It is still unknown whether anxiety disorders observed in Graves' disease are a consequence of increased thyroid hormone levels or precede the onset of Graves' disease.


METHODS
Two case reports are described.


RESULTS
In 2 patients Graves' disease occurred in the setting of previously established euthyroid panic disorder. The interval between the onset of panic disorder and that of hyperthyroidism was 4 and 5 years, respectively. Antithyroid drug treatment reduced psychiatric symptoms, but only to a partial degree.


CONCLUSIONS
The findings indicate that panic disorder may not only be a consequence of Graves' disease but may precede its onset and potentially predispose to its development.
Department of Psychosomatic Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
S
S
Matsubayashi
H
H
Tamaí
Y
Y
Matsumoto
K
K
Tamagawa
T
T
Mukuta
T
T
Morita
C
C
Kubo
D000525:Alprazolam / Q000008:administration & dosage / Q000627:therapeutic use; D001008:Anxiety Disorders / Q000523:psychology; D001569:Benzodiazepines / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006111:Graves Disease / Q000523:psychology*; D006801:Humans; D006980:Hyperthyroidism; D008016:Life Change Events; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology*; D013972:Thyrotropin / Q000097:blood
D001569:Benzodiazepines; D013972:Thyrotropin; D000525:Alprazolam