[The mechanisms of the formation of heterologous resistance in peroral immunization with a complex anti-influenza preparation].
The paper presents experimental findings of the combined antiinfluenza drug (inactivated influenza vaccine + an interferon inducer - an immunogenetic anstimulator - polysaccharide 1,3beta-glucan). The oral immunization with the drug induces antibody accumulation in the secretions of the upper airway and blood sera in defense titers, interferon synthesis at days 1-3 postadministration, forms murine resistance to infection with homologous and heterologous viruses, enhances the functional activity of alveolar macrophages.
Markevich
N A
NA
Maslennikova
I I
II
Pokrovskaia
E E
EE
Osipova
M V
MV
Ispolatova
A V
AV
D000284:Administration, Oral; D000818:Animals; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D005936:Glucans / Q000008:administration & dosage / Q000276:immunology*; D007113:Immunity, Innate; D007114:Immunization / Q000379:methods*; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D007369:Interferon Inducers / Q000008:administration & dosage / Q000276:immunology*; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000517:prevention & control*; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology; D047071:beta-Glucans
D004338:Drug Combinations; D005936:Glucans; D007252:Influenza Vaccines; D007369:Interferon Inducers; D015164:Vaccines, Inactivated; D047071:beta-Glucans; C033363:beta-1,3-glucan