RANTES mRNA expression in skin and colon of patients with atopic dermatitis.
The expression of RANTES mRNA in dermal and colonic tissue was examined in patients with atopic dermatitis by the reverse transcription polymerase chain reaction method. RANTES mRNA was detected in the colon in 8 of 10 patients and in 1 of 5 control patients. It was present in rashes in 9 of 10 patients and at non-eruptive sites in 5 of 7 patients. These findings suggest that RANTES is involved in eosinophil infiltration and T cell infiltration in atopic dermatitis.
Department of Dermatology, Kinki University, Osaka, Japan.
H
H
Yamada
R
R
Izutani
J
J
Chihara
T
T
Yudate
M
M
Matsukura
T
T
Tezuka
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D018946:Chemokine CCL5 / Q000235:genetics*; D002648:Child; D003106:Colon / Q000378:metabolism*; D003113:Colonoscopy; D003876:Dermatitis, Atopic / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D012333:RNA, Messenger / Q000235:genetics; D012867:Skin / Q000378:metabolism*
D018946:Chemokine CCL5; D012333:RNA, Messenger