In vitro binding of iron with the cation-exchange resin sodium polystyrene sulfonate.
OBJECTIVE
To investigate the ability of the cation exchange resin sodium polystyrene sulfonate to bind iron from ferrous sulfate solutions, along with the effects of pH on binding.


METHODS
We performed a series of in vitro experiments in which various concentrations of iron and sodium polystyrene sulfonate were combined and free ferrous iron was measured with the use of a colorimetric assay.


RESULTS
Sodium polystyrene sulfonate bound iron from ferrous sulfate solutions at pH 2 and pH 7. Slightly less binding of free ferrous iron was demonstrated in experiments performed at pH 7 than in those performed at pH 2. At pH 2, 98% of iron was bound, at pH 7, 95% of iron was bound.


CONCLUSIONS
Sodium polystyrene sulfonate may be a useful therapy in acute iron poisoning once safety and efficacy are determined with the use of in vivo models.
O'Connor
T A
TA
Department of Child Health, University of Missouri School of Medicine.
Gruner
B A
BA
Gehrke
J C
JC
Watling
S M
SM
Gehrke
C W
CW
D002411:Cation Exchange Resins / Q000378:metabolism* / Q000494:pharmacology; D005296:Ferrous Compounds / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007501:Iron / Q000378:metabolism* / Q000506:poisoning; D011137:Polystyrenes / Q000378:metabolism* / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism; D012117:Resins, Synthetic / Q000378:metabolism
D002411:Cation Exchange Resins; D005296:Ferrous Compounds; D011137:Polystyrenes; D017382:Reactive Oxygen Species; D012117:Resins, Synthetic; C020748:ferrous sulfate; C003321:polystyrene sulfonic acid; D007501:Iron