The immunopathology of Guillain-Barré syndrome.
Identification of new antigens in different patterns of Guillain-Barré syndrome has led to new pathophysiological concepts of Guillain-Barré syndrome and the related Miller-Fisher syndrome. Patients with Guillain-Barré syndrome occurring after Campylobacter jejuni infection have been found to develop more frequently axonal and motor forms of the syndrome. Anti-GM1 antibodies decreased Na+ current in the presence of complement. In acute axonal Guillain-Barré syndrome, macrophages were found in the periaxonal space without damaging myelin sheath. Important epitopes may be localized on the axolemma, but further studies are needed to confirm these observations.
Itano National Hospital, Department of Neurology, Kyoto, Japan.
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Saida
D000818:Animals; D000906:Antibodies / Q000032:analysis; D001369:Axons / Q000276:immunology / Q000648:ultrastructure; D002169:Campylobacter Infections / Q000150:complications*; D000939:Epitopes / Q000032:analysis; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D011129:Polyradiculoneuropathy / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology
D000906:Antibodies; D000939:Epitopes; D006680:HLA Antigens