Tumorous intrahepatic lymphoproliferative disorder in transplanted livers.
OBJECTIVE
We describe the radiologic findings of lymphoproliferative disorder manifesting as an intrahepatic mass in hepatic transplant recipients. Three patients with focal intrahepatic masses due to lymphoproliferative disorder after transplantation were retrospectively identified. Clinical features and radiologic findings in these patients were reviewed in conjunction with pertinent cases from the literature. (Reports of lymphoproliferative disorder confined to the transplanted liver have been sporadic.)


CONCLUSIONS
Factors supporting the diagnosis of tumorous intrahepatic lymphoproliferative disorder include presentation 4-12 months after transplantation; portal or periportal location; poorly defined extrahepatic periportal soft tissue; encasement or narrowing of the biliary ducts, hepatic artery, or portal vein; and serologic evidence of exposure to Epstein-Barr virus.
Strouse
P J
PJ
Department of Radiology, University of Michigan Medical Center, Ann Arbor 48109-0252, USA.
Platt
J F
JF
Francis
I R
IR
Bree
R L
RL
D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D001653:Bile Ducts, Intrahepatic / Q000473:pathology; D002758:Cholangiography; D003952:Diagnostic Imaging; D005260:Female; D005500:Follow-Up Studies; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology; D016031:Liver Transplantation; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D011169:Portal Vein / Q000473:pathology; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
D000914:Antibodies, Viral