Blood vessel invasion is a major prognostic factor in resected non-small cell lung cancer.
BACKGROUND
We examined the prognostic value of histologic indices in non-small cell lung cancer with particular interest in major blood vessel invasion.


METHODS
We studied 593 patients who had curative resection between November 1983 and December 1988. We determined the histology, T and N status, peritumoral lung tissue invasion, tumor stroma, necrosis, mitotic rate, and blood vessel invasion.


RESULTS
The median patient survival of the whole series was 3.2 years, with a 5-year survival of 38.9%. In univariate analysis, a high T stage, a high percentage of necrosis, blood vessel invasion, and N stage significantly worsened the survival. In multivariate analysis, only blood vessel invasion and, less significantly, T stage and lymph node metastasis remained independent prognostic factors.


CONCLUSIONS
These results highlight the negative prognostic value of blood vessel invasion in non-small cell lung cancer and suggest that blood vessel invasion, T stage, and node metastasis are three unrelated and distinctive characteristics of resected non-small cell lung cancer.
Service de Chirurgie Thoracique, Hôpitaux Universitaires, Strasbourg, France.
R
R
Kessler
B
B
Gasser
G
G
Massard
N
N
Roeslin
P
P
Meyer
J M
JM
Wihlm
G
G
Morand
D000704:Analysis of Variance; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D009336:Necrosis; D009367:Neoplasm Staging / Q000379:methods; D009389:Neovascularization, Pathologic / Q000473:pathology*; D011379:Prognosis; D015203:Reproducibility of Results; D016019:Survival Analysis