U.S. Environmental Protection Agency guidelines for carcinogen risk assessment: past and future.
The U.S. Environmental Protection Agency (USEPA) recently proposed new guidelines to update and replace the 1986 USEPA Guidelines for Carcinogen Risk Assessment. Today, there is a better understanding of the variety of modes by which carcinogens can operate that did not exist when the 1986 USEPA guidelines were published. Many laboratories are adding new test protocols in their programs directed at questions concerning the mechanisms of action of carcinogens. In response to the evolving science of carcinogenesis, the new guidelines provide an analytical framework for incorporating all relevant biological information and recognizing a variety of situations regarding cancer risk. In addition, the guidelines are flexible enough to allow consideration of future scientific advances.
Wiltse
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National Center for Environmental Assessment, U.S. Environmental Protection Agency, Washington, DC 20460, USA.
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D000818:Animals; D002273:Carcinogens / Q000592:standards*; D006801:Humans; D009369:Neoplasms; D018570:Risk Assessment; D014481:United States; D014484:United States Environmental Protection Agency
D002273:Carcinogens