Lipid A and related compounds. XXX. Synthesis of biologically active N,N'-diacyl chitobiose derivatives structurally related to lipid A.
Two new glycolipids, which mimic lipid A disaccharide, were synthesized from N,N'-diacylchitobiose via a key intermediate (2). They showed mitogenicity and nitric oxide (NO) productivity.
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
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Ikeda
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Miyajima
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Achiwa
D004187:Disaccharides; D005936:Glucans / Q000138:chemical synthesis / Q000737:chemistry*; D008050:Lipid A / Q000737:chemistry*; D008934:Mitogens / Q000138:chemical synthesis*; D009569:Nitric Oxide / Q000378:metabolism
D004187:Disaccharides; D005936:Glucans; D008050:Lipid A; D008934:Mitogens; D009569:Nitric Oxide; C032438:chitobiose