Relationship of impaired brain glucose metabolism to learning deficit in the senescence-accelerated mouse.
The relationship between brain glucose metabolism and learning deficit was examined in the senescence-accelerated-prone mouse (SAMP) 8, which has been proven to be a useful murine model of age-related behavioral disorders. SAMP8, 7 months old, exhibited marked learning impairment in the passive avoidance task, as compared with the control strain, senescence-accelerated-resistant mice (SAMR) 1. SAMP8 also exhibited a reduction in brain glucose metabolism, as indicated by a reduction in [14C]2-deoxyglucose accumulation in the brain following the intravenous injection impaired glucose metabolism correlated significantly with the learning impairment in all brain regions in SAMR1 and SAMP8. In the SAMP8, a significant correlation was observed in the posterior half of the cerebral cortex. These results suggest that the SAMP8 strain is a useful model of not only age-related behavioral disorders, but also glucose hypometabolism observed in aging and dementias.
Ohta
H
H
Pharmaceutical Research Laboratories I, Takeda Chemical Industries Ltd., Osaka, Japan. ota_hiroyuki@takeda.co.jp
Nishikawa
H
H
Hirai
K
K
Kato
K
K
Miyamoto
M
M
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D001692:Biological Transport / Q000502:physiology; D001921:Brain / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D007859:Learning Disabilities / Q000378:metabolism*; D016014:Linear Models; D051379:Mice; D008815:Mice, Inbred Strains; D011930:Reaction Time / Q000502:physiology; D018709:Statistics, Nonparametric
D005947:Glucose