Laparoscopic oophorectomy: a prospective evaluation in pre-menopausal breast cancer with particular reference to incidence and severity of menopausal symptoms.
Laparoscopic oophorectomy offers potential advantages over other methods of ovarian ablation. In this prospective study the technique, complications and side-effects have been assessed in 69 consecutive patients. Menopausal symptoms were assessed using two scoring systems - the Kupperman index and the Women's Health Questionnaire. The serum beta oestradiol levels fell rapidly post-operatively (from 540 pmol/l to 25 pmol/l within 1 month). Menopausal symptoms were mild in 75% of patients and severe in none. Complications occurred in three patients. Laparoscopic oophorectomy has an important role to play in the management of pre-menopausal breast cancer and this study confirms that is well tolerated and gives good short-term results.
Department of Surgery, University College Hospital, National Breast Cancer Research Institute, Galway, Ireland.
C J
CJ
O'Boyle
D M
DM
O'Hanlon
M J
MJ
Kerin
M K
MK
Barry
H F
HF
Given
D000328:Adult; D001943:Breast Neoplasms / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects; D008875:Middle Aged; D010052:Ovariectomy / Q000009:adverse effects / Q000379:methods*; D017697:Premenopause; D011446:Prospective Studies