Liver transplantation in Italy: preliminary 10-year report. The Monotematica Aisf-Olt Study Group.
Experience in liver transplantation (OLT) in Italy over a ten-year period is reported. Data were obtained using a multiple-items form collected from Italian liver transplant centres (reference centres) and other Italian institutions actively involved both in the processes of evaluation of the candidates and the follow-up of liver transplant recipients (afference centres). During this period, a total of 1046 liver transplants were performed on 954 patients, with a cumulative proportional survival of 71%. The most common indication for liver transplantation was post-hepatitic cirrhosis due to either hepatitis B virus (+/-hepatitis Delta virus) or hepatitis C virus infection. Good survival rates were observed, particularly in controversial indications, such as alcoholic cirrhosis, post-hepatitic hepatitis B virus-related cirrhosis and hepatocellular carcinoma, most likely due to proper and careful selection of the patients. Cirrhosis, secondary to an autoimmunity-based liver disease, showed the highest rate of rejection episodes. Infections, in our study population, were the most common cause of death after transplantation.
Cattedra di Malattie dell'Apparato Digerente, Università di Padova, Italy.
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Fagiuoli
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Leandro
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Bellati
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Gasbarrini
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Rapaccini
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Pompili
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Rendina
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De Notariis
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Francavilla
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Gasbarrini
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Ideo
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Naccarato
D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007558:Italy / Q000453:epidemiology; D008107:Liver Diseases / Q000601:surgery*; D016031:Liver Transplantation / Q000401:mortality; D008297:Male; D011183:Postoperative Complications; D012189:Retrospective Studies; D015996:Survival Rate
D007166:Immunosuppressive Agents