Synergistic effect of aurintricarboxylic acid and triflavin in a photochemically induced thrombosis model in rats.
We report here the synergistic antithrombotic effect of aurintricarboxylic acid in combination with a snake venom-derived disintegrin, triflavin, in a photochemically induced thrombosis model in rats. The time to initiation of thrombus was prolonged by i.v. bolus injection of aurintricarboxylic acid at 10 mg/kg. In contrast, time to occlusion was dose-dependently prolonged by both agents, this prolongation being significant with aurintricarboxylic acid at 10 mg/kg i.v. and with triflavin at more than 3 mg/kg i.v. Interestingly, the combination of aurintricarboxylic acid at 3 mg/kg i.v. and triflavin at 1 mg/kg i.v. prolonged not only the initiation of thrombus, but also the time to occlusion.
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd, Ibaraki, Japan.
N
N
Hisamichi
T
T
Kawasaki
K
K
Suzuki
S
S
Kaku
Y
Y
Sakai
Y
Y
Taniuchi
K
K
Sato
O
O
Inagaki
K
K
Tomioka
I
I
Yanagisawa
T
T
Takenaka
K
K
Yanagi
N
N
Ohshima
D000818:Animals; D001312:Aurintricarboxylic Acid / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D008297:Male; D010455:Peptides / Q000008:administration & dosage*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000037:antagonists & inhibitors; D051381:Rats; D017208:Rats, Wistar; D013927:Thrombosis / Q000188:drug therapy*
D005343:Fibrinolytic Agents; D010455:Peptides; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D019038:Platelet Glycoprotein GPIb-IX Complex; C070025:triflavin; D001312:Aurintricarboxylic Acid