Helicobacter pylori and lymphoid follicles in primary gastric MALT-lymphoma in Mexico.
We reviewed our cases of gastric MALT-lymphomas over a 12-year period at a national oncological referral center, the Instituto Nacional de Cancerología in Mexico City, looking for morphological evidence of Helicobacter pylori infection near the primary neoplasia. H pylori as well as lymphoid follicles and chronic active gastritis were carefully searched for in the adjacent mucosa. There were 23 (85%) low-grade and four (15%) high-grade MALT-lymphomas. H pylori microorganisms were found adjacent to the neoplasia in 23 cases (85%; CI 95% = 72-99%) but the lymphoid follicles were seen in 15 of 23 (65%; CI = 56-74%). Chronic active gastritis was present in 25 cases (93%; Cl = 90-95%). There was a close association between H pylori and gastric MALT-lymphoma. Lymphoid follicles were a reliable indicator of infection and the claimed pathophysiological substrate for MALT-lymphoma. We conclude that patients in whom gastric lymphoid follicles are detected, must remain under clinical follow-up since H pylori is a plausible promoter of neoplastic transformation.
Department of Pathology, Instituto Nacional de Cancerologia, Mexico City.
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R
Herrera-Goepfert
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R
Garcia-Marcano
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Zeichner-Gancz
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000382:microbiology*