Attack of cefotaxime by different radicals: comparison of the effects.
Free radicals are physiological products and can react to administrated drugs. Metabolic transformations by radical mechanisms are, therefore, possible. A fundamental study of radio-induced degradation of aqueous solutions of sodium cefotaxime, a third generation cephalosporin, was realized to describe these possible radical mechanisms. Different radicals produced by the radiolysis method (.OH, N3., Br2.-, Tbut., eaq- + .OH, and exq- + Tbut.) were successively used to induce the radical mechanisms and their effects were compared. All these radicals induce the formation of a same main radiolysis product identified as anticefotaxime. Radical mechanisms induced by N3., Tbut., and eaq- include chain reactions to explain the formation of anticefotaxime contrary to those induced by .OH and Br2.-.
Unité d'Analyse Chimique et Physico-Chimique des Médicaments, Université Catholique de Louvain UCL-72 30, Bruxelles, Belgique.
A S
AS
Crucq
B L
BL
Tilquin
D001386:Azides / Q000737:chemistry; D001966:Bromine / Q000737:chemistry; D002439:Cefotaxime / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D003037:Cobalt Radioisotopes; D005609:Free Radicals; D017665:Hydroxyl Radical / Q000737:chemistry; D011675:Pulse Radiolysis; D012996:Solutions; D013053:Spectrophotometry
D001386:Azides; D003037:Cobalt Radioisotopes; D005609:Free Radicals; D012996:Solutions; D017665:Hydroxyl Radical; D002439:Cefotaxime; D001966:Bromine