Myocardial stunning, hibernation, and ischemic preconditioning.
From the present review, it may be concluded that myocardial ischemia results in far more complicated syndromes than previously realized. Although not all aspects of the issues discussed in this review are currently a clinical reality in the daily practice of cardiovascular anesthesiologists, the understanding and application of these concepts are growing rapidly. Indications for revascularization procedures will be adjusted in patients with evidence of hibernating myocardium. In the future, postoperative myocardial dysfunction may be diminished by the prevention of myocardial stunning, for instance by altering the composition of the cardioplegic solution and other interventions. Finally, additional advances may involve reduction of the extent of perioperative myocardial infarctions by application of ischemic preconditioning.
Department of Anesthesiology, Academic Medical Center, Amsterdam, The Netherlands.
M B
MB
Vroom
H B
HB
van Wezel
D000787:Angina Pectoris / Q000150:complications; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology; D006348:Cardiac Surgical Procedures / Q000009:adverse effects; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D015428:Myocardial Reperfusion Injury / Q000150:complications*; D017682:Myocardial Stunning / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy