Atypical prolymphocytic variant of hairy-cell leukemia: case report and review of the literature.
The prolymphocytic variant of hairy-cell leukemia (HCL-V) is relatively rare and differs from typical hairy-cell leukemia (HCL) both clinically and morphologically. Recognition of HCL-V is important due to therapeutic impact. We report on a case of HCL-V, atypical in its degree of marrow fibrosis, IgM/lambda monoclonality, expression of CD24, and the ultrastructural presence of ribosomal lamellar complexes. The patient was treated with splenectomy followed by pentostatin, and he achieved a partial response.
Department of Pathology, St. Louis University Health Sciences Center, Missouri 63104, USA.
C H
CH
Dunphy
P J
PJ
Petruska
D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D005434:Flow Cytometry; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000473:pathology*; D015463:Leukemia, Prolymphocytic / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron