Sea-blue histiocyte syndrome in bone marrow secondary to total parenteral nutrition including fat-emulsion sources: a clinicopathologic study of seven cases.
Bone marrow examination revealed a lipid-laden histiocytosis in seven patients undergoing long-term total parenteral nutrition necessitated by extensive short-bowel surgical resection. Clinical abnormalities occurred during this treatment which required bone marrow examination. These included hepatosplenomegaly and peripheral blood cytopenia; the median time to the detection of these abnormalities was 64 months. The most striking change within the bone marrow was the presence of many pigment-laden histiocytes which had the typical morphology of sea-blue histiocytes seen in the so-called idiopathic sea-blue histiocyte syndrome. The occurrence of sea-blue histiocytosis in the bone marrow in association with long-term parenteral nutrition for short-bowel syndrome has not, to our knowledge, been reported previously and should now be considered in the differential diagnosis of bone marrow sea-blue histiocytosis.
Service Central Jacques Delarue d'Anatomie et de Cytologie Pathologiques, Hôpital Hôtel-Dieu, Paris, France.
C
C
Bigorgne
A
A
Le Tourneau
B
B
Messing
B
B
Rio
V
V
Giraud
T
T
Molina
J
J
Audouin
J
J
Diebold
D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D005217:Fat Emulsions, Intravenous / Q000009:adverse effects*; D006801:Humans; D008264:Macrophages / Q000473:pathology; D008875:Middle Aged; D010288:Parenteral Nutrition / Q000009:adverse effects*; D012618:Sea-Blue Histiocyte Syndrome / Q000209:etiology* / Q000473:pathology
D005217:Fat Emulsions, Intravenous