Aminoacyl-tRNA synthetase gene regulation in Bacillus subtilis.
In this review, we summarize progress on the regulation of the aminoacyl-tRNA synthetase genes in Bacillus subtilis. Most of the genes encoding this set of enzymes in B subtilis are members of a large family of Gram-positive genes and operons controlled by a novel antitermination mechanism that uses their cognate uncharged tRNA as the effector. A subset of these genes is, in addition, likely to be controlled at the level of mRNA processing and degradation. We describe the key experiments leading to these conclusions.
UPR 9073, Institut de Biologie Physico-Chimique, Paris, France.
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Condon
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Grunberg-Manago
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Putzer
D000604:Amino Acyl-tRNA Synthetases / Q000235:genetics*; D001412:Bacillus subtilis / Q000201:enzymology* / Q000235:genetics*; D001483:Base Sequence; D002874:Chromosome Mapping; D017124:Conserved Sequence; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics*; D008969:Molecular Sequence Data; D012323:RNA Processing, Post-Transcriptional; D017421:Sequence Analysis; D014158:Transcription, Genetic / Q000235:genetics
D000604:Amino Acyl-tRNA Synthetases