Enhanced in vitro activity of pyrimethamine in combination with dapsone against Mycobacterium avium complex.
The in vitro activities of pyrimethamine and dapsone alone and in combination were evaluated against 23 clinical isolates of Mycobacterium avium complex. The broth dilution MICs of dapsone and pyrimethamine alone ranged from 16 to > 64 micrograms/ml. Pyrimethamine in combination with a fixed concentration of dapsone at 0.5 microgram/ml showed enhanced activity, with an MIC range of 0.5 to 16 micrograms/ml.
Veterans Affairs Medical Center, Syracuse, New York, USA.
L M
LM
Shah
S C
SC
Meyer
M H
MH
Cynamon
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003622:Dapsone / Q000494:pharmacology*; D004338:Drug Combinations; D004357:Drug Synergism; D006801:Humans; D008826:Microbial Sensitivity Tests; D015269:Mycobacterium avium Complex / Q000187:drug effects*; D015270:Mycobacterium avium-intracellulare Infection / Q000382:microbiology; D011739:Pyrimethamine / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D003622:Dapsone; D011739:Pyrimethamine