Cell surface receptor directed targeting of toxin to human malaria parasite, Plasmodium falciparum.
Gelonin (a toxin and type II ribosome inactivating protein) when linked to human transferrin can be targeted to Plasmodium falciparum. The transferrin toxin conjugate is significantly toxic to parasite growth and is 25 times more potent than toxin alone in inhibiting parasite protein synthesis. The mechanism of its entry into the intraerythrocytic parasite is discussed.
Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, India. surolia@mbu.iisc.ernet.in
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Surolia
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D000818:Animals; D000906:Antibodies; D000962:Antimalarials / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001665:Binding Sites; D003600:Cytosol / Q000187:drug effects / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D000922:Immunotoxins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D010940:Plant Proteins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development; D011233:Precipitin Tests; D011500:Protein Synthesis Inhibitors / Q000737:chemistry / Q000494:pharmacology; D011990:Receptors, Transferrin / Q000378:metabolism; D054789:Ribosome Inactivating Proteins, Type 1; D012276:Ricin / Q000737:chemistry / Q000494:pharmacology; D014168:Transferrin / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology*
D000906:Antibodies; D000962:Antimalarials; D000922:Immunotoxins; D010940:Plant Proteins; D011500:Protein Synthesis Inhibitors; D011990:Receptors, Transferrin; D054789:Ribosome Inactivating Proteins, Type 1; D014168:Transferrin; C025674:GEL protein, Gelonium multiflorum; D012276:Ricin