Patterning the vertebrate neuraxis.
Neuraxial patterning is a continuous process that extends over a protracted period of development. During gastrulation a crude anteroposterior pattern, detectable by molecular markers, is conferred on the neuroectoderm by signals from the endomesoderm that are largely inseparable from those of neural induction itself. This coarse-grained pattern is subsequently reinforced and refined by diverse, locally acting mechanisms. Segmentation and long-range signaling from organizing centers are prominent among the emerging principles governing regional pattern.
Department of Developmental Neurobiology, United Medical and Dental Schools, Guy's Hospital, London SE1 9RT, UK. a.lumsden@umds.ac.uk
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D000818:Animals; D019521:Body Patterning; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology* / Q000502:physiology; D004627:Embryonic Induction; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox; D008636:Mesencephalon / Q000166:cytology / Q000196:embryology / Q000502:physiology; D008648:Mesoderm / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology; D016548:Prosencephalon / Q000166:cytology / Q000196:embryology / Q000502:physiology; D012249:Rhombencephalon / Q000166:cytology / Q000196:embryology / Q000502:physiology; D015398:Signal Transduction; D013116:Spinal Cord / Q000166:cytology / Q000196:embryology / Q000502:physiology; D014212:Tretinoin / Q000502:physiology
D014212:Tretinoin