pros-Methylimidazoleacetic acid in cerebrospinal fluid of patients with chronic schizophrenia: relationships to ratings of symptoms, ventricular brain ratios, and rates of urine excretion.
Concentrations of pros-methylimidazoleacetic acid (p-MIAA) were measured in cerebrospinal fluid of 30 patients with chronic schizophrenia. Levels of p-MIAA correlated negatively with mean scores of the Psychiatric Symptom Assessment Scale for positive symptoms (r = -0.48), but not negative symptoms, and with ventricular brain ratios (r = -0.48). Patients with abnormal ventricular enlargements had much lower concentrations of p-MIAA than those with normal ventricles. These results suggest that processes that reduce accumulation of p-MIAA in CSF may be associated with increased severity of symptoms among patients with chronic schizophrenia.
Prell
G D
GD
Department of Pharmacology, Mount Sinai School of Medicine, City University of New York, New York 10029-6574, USA.
Green
J P
JP
Khandelwal
J K
JK
Wyatt
R J
RJ
Lawson
W B
WB
Jaeger
A C
AC
Kaufmann
C A
CA
Kirch
D G
DG
D000328:Adult; D002552:Cerebral Ventricles / Q000378:metabolism*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D012559:Schizophrenia / Q000134:cerebrospinal fluid* / Q000652:urine*; D014556:Urine
D007093:Imidazoles; C002667:methylimidazoleacetic acid