Brain stem auditory-evoked potentials of mice with experimental allergic encephalomyelitis.
Experimental allergic encephalomyelitis (EAE) is an experimental model for multiple sclerosis. In order to study autoimmune retrocochlear hearing loss, we performed brain stem auditory-evoked potential (BAEP) studies on EAE mice. The EAE was induced in B10.PL and (PL/J x SJL)F1 mice. In the BAEP study, all of the peak and interpeak latencies were prolonged significantly in the diseased mice. Hearing thresholds were slightly elevated in the immunized mice during the acute phase. Inflammatory and phagocytic cell infiltration, demyelination, and V beta 8.1, 8.2 T-cell receptor-positive cells were observed in the cochlear nerves or their proximity by histologic study. It is suggested that immunologic reactions identified with EAE also occurred in the cochlear nerve, and that these reactions were responsible for the hearing problems. It appears that EAE is a useful model system for studying autoimmune insults on the neural portion of the auditory system.
Division of Allergy and Immunology, University of Tennessee, Memphis 38163, USA.
T
T
Watanabe
K C
KC
Cheng
M S
MS
Krug
T J
TJ
Yoo
D000818:Animals; D003056:Cochlear Nerve / Q000378:metabolism / Q000473:pathology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005260:Female; D006311:Hearing Disorders / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D006320:Hearing Tests; D007124:Immunoenzyme Techniques; D008297:Male; D051379:Mice; D004676:Myelin Basic Protein; D010586:Phagocytes / Q000473:pathology; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000378:metabolism
D004676:Myelin Basic Protein; D016693:Receptors, Antigen, T-Cell, alpha-beta