The effects of particulate polyethylene at a weight-bearing bone-implant interface. A study in rats.
In ten male rats we inserted ceramic 'drawing-pin' implants in weight-bearing positions within the right proximal tibia. Two animals were killed 6 weeks after surgery and two more 14 weeks after surgery. The remaining six received intra-articular injections of either high-density polyethylene (4 rats) or saline (2 rats) at 8, 10 and 12 weeks after surgery. These animals were killed two weeks after the last injection. Histological examination of the bone-implant interface in the control animals showed appositional bone growth around the implant at both 6 and 14 weeks. Polyethylene, but not saline, caused a chronic inflammatory response with numerous foreign-body giant cells in periprosthetic tissues. Our model of a stable, weight-bearing bone-implant interface provides a simple and reliable system in which to study in vivo the effects of particulate materials used in orthopaedic surgery.
Addenbrooke's Hospital, Cambridge, England.
M
M
Allen
F
F
Brett
P
P
Millett
N
N
Rushton
D000818:Animals; D007270:Injections, Intra-Articular; D008297:Male; D016348:Osseointegration; D011095:Polyethylenes / Q000008:administration & dosage*; D019736:Prostheses and Implants; D011859:Radiography; D051381:Rats; D017207:Rats, Sprague-Dawley; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*
D011095:Polyethylenes