New pharmacologic strategies for acute neuronal injury.
The number of new drugs for treating neurotrauma is rapidly expanding. Emerging theories regarding the mechanisms of secondary neuronal injury provide the scientific basis for evaluating these new agents. Some of the most promising mechanisms for intervention are ionotropic channel antagonism, inhibition of lipid peroxidation, and neurotrophic factor augmentation. Many of these new agents are undergoing clinical trials to establish their roles in therapy.
Luer
M S
MS
Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock 72205, USA.
Rhoney
D H
DH
Hughes
M
M
Hatton
J
J
D001930:Brain Injuries / Q000188:drug therapy* / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000209:etiology; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D013124:Spinal Injuries / Q000188:drug therapy* / Q000503:physiopathology
D015220:Calcium Channels; D005609:Free Radicals; D018696:Neuroprotective Agents; D016194:Receptors, N-Methyl-D-Aspartate; D002118:Calcium