Absorption and disposition kinetics of the dietary antioxidant quercetin in man.
Quercetin is a dietary antioxidant that prevents oxidation of low-density lipoproteins in vitro by scavenging to free oxygen radicals. Its intake was inversely associated with coronary heart mortality in Dutch elderly men. However, data on absorption of quercetin in man are scarce and contradictory. We studied the time course of the plasma quercetin concentration in two subjects after ingestion of fried onions containing quercetin glucosides equivalent to 64 mg of quercetin aglycone. Peak plasma levels of 196 ng/ml were reached after 2.9 h, with a half-life of absorption of 0.87 h. The half-life of the distribution phase was 3.8 h, and of the subsequent elimination phase 16.8 h. After 48 h the plasma concentration was about 10 ng/ml. We conclude that quercetin glucosides from onions are absorbed and are eliminated slowly throughout the day. Thus, the dietary antioxidant quercetin could increase the antioxidant capacity of blood plasma.
Hollman
P C
PC
DLO-State Institute of Quality Control of Agricultural Products (RIKILT-DLO), Wageningen, The Netherlands.
vd Gaag
M
M
Mengelers
M J
MJ
van Trijp
J M
JM
de Vries
J H
JH
Katan
M B
MB
D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004032:Diet; D005260:Female; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D011794:Quercetin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics*
D000975:Antioxidants; D016166:Free Radical Scavengers; D011794:Quercetin; C080613:spiraeoside