Trandolapril plus verapamil inhibits the coronary vasospasm induced by hypoxia following ischemia-reperfusion injury in dogs.
1. Dogs were exposed to hypoxemia followed by a coronary angiogram at three different times: under control conditions, after ischemia-reperfusion injury, then 30 min later. 2. In the study group, the dogs were treated with trandolapril (0.05 mg/kg) and verapamil (0.1 mg/ kg) just prior to the final hypoxic challenge. 3. Under control conditions, the left anterior descending coronary artery (LAD) dilated in response to hypoxia. Following ischemia-reperfusion injury, however, it constricted significantly in response. 4. In the control group, repeat hypoxia 30 min later resulted in vasoconstriction of the LAD which was comparable to the preceding response. 5. However, in the study group, treatment with trandolapril plus verapamil inhibited the vasoconstriction in response to repeat hypoxia.
Division of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
J J
JJ
Lee
C M
CM
Boulanger
M
M
Kirchengast
P M
PM
Vanhoutte
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage*; D000818:Animals; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D003329:Coronary Vasospasm / Q000209:etiology / Q000517:prevention & control*; D004285:Dogs; D004359:Drug Therapy, Combination; D005260:Female; D000860:Hypoxia / Q000150:complications*; D007211:Indoles / Q000008:administration & dosage*; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000150:complications*; D014700:Verapamil / Q000008:administration & dosage*
D000806:Angiotensin-Converting Enzyme Inhibitors; D002121:Calcium Channel Blockers; D007211:Indoles; C052035:trandolapril; D014700:Verapamil