In vitro and in vivo characterization of a 99mTc complex with tris(hydroxymethyl)phosphine (THP).
The water-soluble, monophosphine ligand tris(hydroxymethyl)phosphine (THMP) was complexed with 99mTc. The 99mTc-THMP was formed in high radiochemical purity by simply mixing 99mTcO4- with THMP over a wide pH range. In vitro and in vivo studies indicated the complex to be highly stable under the respective conditions. HPLC analysis indicated a singular species with a retention time identical to the known [ReO2(THMP)4]1 complex. Results show that the hydroxymethylphosphine functionality is attractive for use in designing new 99mTc radiopharmaceuticals.
Berning
D E
DE
Department of Chemistry, University of Missouri, Columbia, USA.
Katti
K V
KV
Singh
P R
PR
Higgenbotham
C
C
Reddy
V S
VS
Volkert
W A
WA
D000818:Animals; D001769:Blood; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007553:Isotope Labeling / Q000379:methods; D015609:Organotechnetium Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics*; D010720:Phosphines / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013667:Technetium; D014018:Tissue Distribution
D015609:Organotechnetium Compounds; D010720:Phosphines; C103804:technetium Tc 99m tris(hydroxymethyl)phosphine; D013667:Technetium