Linkage disequilibrium studies in the thyroid peroxidase and apolipoprotein B genes.
Linkage disequilibria in the apolipoprotein B (APOB) gene (EcoRI RFLP/3' APOB VNTR) and in the thyroid peroxidase (TPO) gene (AcyI RFLP/TPO VNTR) were investigated in a sample of 100 individuals from southern Italy. By recoding multiallelic data as diallelic data, each RFLP-VNTR system showed linkage disequilibrium significantly different from zero (EcoRI RFLP/3' APOB VNTR: p < 0.001; AcyI RFLP/TPO VNTR: p < 0.025), thus suggesting that the VNTR arrays are stable. Furthermore, the relationship between the 3' APOB (2p24-p23) and TPO (2pter-p24) VNTR multiallelic systems was also analyzed. The two VNTR polymorphisms were found to be in linkage equilibrium, thus indicating that they can be used together in forensic casework.
Department of Cell Biology, University of Calabria, Rende, Italy.
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D001055:Apolipoproteins B / Q000235:genetics*; D016172:DNA Fingerprinting; D005787:Gene Frequency; D006801:Humans; D007453:Iodide Peroxidase / Q000235:genetics*; D007558:Italy; D015810:Linkage Disequilibrium / Q000235:genetics*; D018598:Minisatellite Repeats / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012494:Sampling Studies
D001055:Apolipoproteins B; D007453:Iodide Peroxidase