Effects of frusemide on the urinary excretion of dopamine and 5-hydroxytryptamine in normal man.
The effects of frusemide on the urinary excretion of dopamine and 5-hydroxytryptamine (5-HT) were investigated in eight healthy male subjects in a randomized, placebo-controlled, cross-over study. Frusemide produced the expected rise in urinary dopamine excretion but it did not affect 5-HT excretion when compared with placebo. The lack of an effect on 5-HT excretion in man contrasts with studies in the rat which have reported a marked increase in 5-HT excretion after administration of this loop diuretic.
Department of Medicine, Royal Infirmary, Edinburgh, UK.
T C
TC
Li Kam Wa
S
S
Freestone
J L
JL
McCrindle
R R
RR
Samson
N R
NR
Johnston
M R
MR
Lee
D000328:Adult; D004232:Diuretics / Q000652:urine*; D004298:Dopamine / Q000652:urine*; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010919:Placebos; D012701:Serotonin / Q000652:urine*
D004232:Diuretics; D010919:Placebos; D012701:Serotonin; D005665:Furosemide; D004298:Dopamine