[The impaired glucose tolerance in the pathogenesis of dyslipidemia].
It is well known that hyperlipidemia is often present in patient with impaired glucose tolerance, obesity and/or hypertension. All of these are risk factors for coronary artery disease (CAD). The coexistence of these risk factors markedly increase the likelihood of CAD. Recently, it has been reported that the impaired glucose tolerance and insulin resistence are associated with the increased proinsulin, which is linked to the risk of CAD. We review that the impaired glucose tolerance is an important factor causing dyslipidemia. The characteristic of dyslipidemia associated with the impaired glucose tolerance include hypertriglyceridemia, high level of VLDL and low level of HDL cholesterol. They also associate with accumulation of remnant lipoproteins and appearance of small dense LDL. In addition, we pointed out that the increased number of risk factors is associated with elevated insulin and proinsulin level.
Fourth Department of Medicine, Saitama Medical School.
I
I
Ikoue
K
K
Takahashi
S
S
Katayama
D003327:Coronary Disease / Q000209:etiology; D018149:Glucose Intolerance / Q000150:complications*; D006801:Humans; D006949:Hyperlipidemias / Q000209:etiology*; D006973:Hypertension / Q000150:complications; D007333:Insulin Resistance; D009765:Obesity / Q000150:complications; D011384:Proinsulin / Q000097:blood; D012307:Risk Factors
D011384:Proinsulin