Analysis of factors affecting the graft oxygenation state in living related liver transplantation.
OBJECTIVE
In liver transplantation, graft dysoxia after reperfusion may lead to graft failure. The aim of this study is to investigate the relationship between the factors, which were supposed to affect the oxygen supply to the graft, and the oxygenation state of the graft in order to determine which factor is important to prevent the graft from dysoxia.


METHODS
The relationship between oxygen supply and oxygenation state of the graft was investigated in 56 successful cases of living related liver transplantation. Factors affecting the oxygen supply to the graft were considered as follows; portal venous flow (PVF), mean velocity of the hepatic artery (HA-Vm), hemoglobin concentration in the peripheral blood (Hb), size of the graft liver relative to the recipient body weight (G/R ratio), partial oxygen pressure in the arterial blood (PaO2), and rate-pressure product (BP*PR). Oxygenation state of the graft was estimated by oxygen saturation of hemoglobin in the graft tissue (graft SO2) as measured by tissue near infrared spectroscopy.


RESULTS
1) Graft SO2 was rather independent of PVF and HA-Vm probably due to compensatory interrelation between the portal venous flow and hepatic arterial flow. 2) Significant correlation between G/R ratio and graft SO2 was observed after portal reflow (p < 0.01), but the correlation diminished after hepatic arterial reflow. Positive correlation between G/R ratio and AKBR after portal reflow suggested that the graft with large G/R ratio is likely to suffer dysoxia early after reperfusion. 3) Graft SO2 was positively correlated with Hb (p < 0.05), while there was no significant correlation between graft SO2 and PaO2 or BP*PR.


CONCLUSIONS
This study clarified the contribution of the factors which were supposed to affect the oxygen supply to the graft and the oxygenation state of the graft, and which factor is important to prevent the graft from dysoxia.
Second Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
A
A
Tokuka
T
T
Kitai
A
A
Tanaka
N
N
Yanabu
B
B
Sato
S
S
Mori
T
T
Inomoto
H
H
Shinohara
Y
Y
Yamaoka
S
S
Uemoto
K
K
Tanaka
H
H
Someda
M
M
Fujimoto
F
F
Moriyasu
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006084:Graft Rejection / Q000503:physiopathology*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007223:Infant; D007657:Ketone Bodies / Q000097:blood; D016031:Liver Transplantation / Q000502:physiology*; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D011169:Portal Vein / Q000502:physiology; D012039:Regional Blood Flow; D015424:Reperfusion; D019265:Spectroscopy, Near-Infrared; D014184:Transplantation, Homologous
D006454:Hemoglobins; D007657:Ketone Bodies; D010100:Oxygen