Rapid microscale synthesis, a new method for lead optimization using robotics and solution phase chemistry: application to the synthesis and optimization of corticotropin-releasing factor1 receptor antagonists.
Whitten
J P
JP
Neurocrine Biosciences, San Diego, California 92121, USA.
Xie
Y F
YF
Erickson
P E
PE
Webb
T R
TR
De Souza
E B
EB
Grigoriadis
D E
DE
McCarthy
J R
JR
D002460:Cell Line; D004339:Drug Compounding / Q000379:methods*; D006801:Humans; D018019:Receptors, Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D012371:Robotics / Q000379:methods; D012996:Solutions; D014162:Transfection; D014227:Triazines / Q000737:chemistry*; D000099052:CRF Receptor, Type 1
D018019:Receptors, Corticotropin-Releasing Hormone; D012996:Solutions; D014227:Triazines; D000099052:CRF Receptor, Type 1