Polyalthidin: new prenylated benzopyran inhibitor of the mammalian mitochondrial respiratory chain.
Polyalthidin (3), a new benzopyran derivative, was isolated from the stem bark of Polyalthia cerasoides. Its structure was established on the basis of chemical and spectral evidence. Polyalthidin has showed potent biological activity as an inhibitor of the mammalian mitochondrial respiratory chain.
Departamento de Farmacología, Farmacognosia y Farmacodinamia, Facultadde Farmacia, Universidad de Valencia, Spain.
M C
MC
Zafra-Polo
M C
MC
González
J R
JR
Tormo
E
E
Estornell
D
D
Cortes
D000818:Animals; D001578:Benzopyrans / Q000302:isolation & purification* / Q000494:pharmacology; D002417:Cattle; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D008929:Mitochondria, Heart / Q000187:drug effects / Q000201:enzymology; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors; D019441:Plant Epidermis / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D001578:Benzopyrans; D004791:Enzyme Inhibitors; D005231:Fatty Acids, Unsaturated; C102476:polyalthidin; D009247:NADH, NADPH Oxidoreductases