[Clinical pilot study of the myogenic effects of flupirtine in comparison to tetrazepam and placebo].
The effects of flupirtine (CAS 56995-20-1, D-9998, Katadolon) on muscle force and related electromyographic (EMG) activity has been assessed in comparison to tetrazepam and placebo in 12 healthy male volunteers after oral single-dose administration and under steady-state conditions. Muscle functions primarily reflecting dynamic daily demands remained unaffected under flupirtine in contrast to tetrazepam, the latter exhibiting the typical signs of increased (co-)innervation which can be interpreted as a compensation of a decrease of muscle force. Under conditions that serve as a model for static-spastic situations, flupirtine showed a decrease, tetrazepam a typical increase in the force parameter. Under the same conditions, a decrease of the EMG-amplitude was observed for flupirtine and, to a lesser extent, for tetrazepam as well. With respect to its muscle relaxing property, flupirtine differs both, quantitatively and qualitatively from tetrazepam, which has shown effects common for benzodiazepines.
Konzernforschung der ASTA Medica AG, Frankfurt/Main.
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M
Lobisch
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K
Schaffler
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H
Wauschkuhn
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B
Nickel
D000328:Adult; D000631:Aminopyridines / Q000494:pharmacology*; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology*; D004576:Electromyography / Q000187:drug effects; D006181:H-Reflex / Q000187:drug effects; D006801:Humans; D007537:Isometric Contraction / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D018482:Muscle, Skeletal / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010865:Pilot Projects
D000631:Aminopyridines; D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D009125:Muscle Relaxants, Central; D018696:Neuroprotective Agents; D001569:Benzodiazepines; C005245:tetrazepam; C034161:flupirtine