Duration of antibiotic treatment in surgical infections of the abdomen. The role of shock.
Emergency laparotomy requiring perioperative antibiotics is often accompanied by shock. Whether the shock is the result of haemorrhage, sepsis, cardiac disease, or vasodilatation, it represents a profound metabolic alteration which impairs cellular metabolism, causes immunosuppression, and alters pharmacokinetics. These changes lead to an increased risk of infection, which can be overcome, at least in part, by increasing the dose and (probably) the duration of perioperative antibiotics.
Bergstein
J M
JM
Department of Surgery, Medical College of Wisconsin, Milwaukee, USA. bergstei@post.its.mcw.edu
D000005:Abdomen; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001424:Bacterial Infections / Q000188:drug therapy; D004630:Emergencies; D006801:Humans; D007108:Immune Tolerance; D007430:Intraoperative Care; D007813:Laparotomy; D012769:Shock / Q000145:classification* / Q000276:immunology
D000900:Anti-Bacterial Agents