Phosphatidylcholine hydrolysis and protein kinase C activation for intracellular signaling network.
Agonist-stimulated inositol phospholipid hydrolysis by phospholipase C was once thought to be the sole mechanism to produce diacylgylcerol that transduce extracellular signals into intracellular events through activation of protein kinase C. It is becoming clear that agonist-induced hydrolysis, of the other membrane phospholipids, particularly phosphatidylcholine, by phospholipase A2 and phospholipase D also takes part in cellular responses such as cell proliferation and differentiation. Possibly, the members of the protein kinase C family may be activated differently by various combinations of phospholipid degradation products, and play each distinct role in signal transduction for the control of various cellular functions.
Nakamura
S
S
Department of Biochemistry, Kobe University School of Medicine, Japan.
D000818:Animals; D004789:Enzyme Activation; D006801:Humans; D006868:Hydrolysis; D010713:Phosphatidylcholines / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism*; D015398:Signal Transduction
D010713:Phosphatidylcholines; D011493:Protein Kinase C