Familial occurrence of electrocardiographic abnormalities of the Brugada-type.
Electrocardiographic abnormalities were pointed out in a 51-year-old Japanese male whose major complaint was dizziness. His electrocardiogram showed a complete right bundle branch block, and a prolonged His bundle-ventricle (HV) interval of 100 msec. Two members of his family died of heart disease and 3 members, including a case of sudden death, presented an abnormal electrocardiogram of the Brugada-type with persistent ST segment elevation in the right precordial leads and right bundle branch block. The signal-averaged examination was made in the children of cases that died with the diagnosis of sudden death. Four cases showed a tendency of delay in the HV interval and a positive finding in the late potential. Further studies are necessary to clarify the relationship between electrocardiographic abnormalities of the Brugada-type and atrioventricular conduction disorder as well as to clarify the genetic basis of this disorder.
Kobayashi
T
T
Department of Internal Medicine, Tsu National Hospital, Hisai.
Shintani
U
U
Yamamoto
T
T
Shida
S
S
Isshiki
N
N
Tanaka
T
T
Ohmoto
Y
Y
Kitamura
M
M
Kato
S
S
Misaki
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D002037:Bundle-Branch Block / Q000235:genetics / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D014693:Ventricular Fibrillation / Q000235:genetics* / Q000503:physiopathology*