[The search for ways to improve the efficacy of tuberculosis revaccination in children with immunological deficiency].
Clinicoimmunological examination of children to be BCG revaccinated showed 50% of them to have immunodeficiency. Primarily T-cell and macrophagal components of immunity were compromised. The study of immune response to BCG in animals with T-cell and macrophage immunodeficiency validated feasibility of improving antituberculous vaccination efficacy by using thymalin and sodium nucleinate.
E F
EF
Chernushenko
L P
LP
Kadan
I F
IF
Kruglova
E A
EA
Podgainaia
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000293:Adolescent; D000818:Animals; D001500:BCG Vaccine / Q000276:immunology*; D002648:Child; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007111:Immunity, Cellular; D007117:Immunization, Secondary / Q000379:methods*; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D051379:Mice; D009696:Nucleic Acids / Q000008:administration & dosage; D013951:Thymus Hormones / Q000008:administration & dosage; D014374:Tuberculin Test / Q000706:statistics & numerical data; D014397:Tuberculosis, Pulmonary / Q000276:immunology / Q000517:prevention & control*; D014455:Ukraine; D014505:Urban Population
D000276:Adjuvants, Immunologic; D001500:BCG Vaccine; D009696:Nucleic Acids; D013951:Thymus Hormones; C032805:thymalin; C013683:sodium nucleinate