Alcoholic myopathies.
Ethanol consumption may produce acute or chronic changes in striated skeletal muscle in a dose-dependent manner. The physiopathological mechanisms for such changes are probably related to alterations in membrane fluidity, channels, pumps and ionic transients, depression of muscle contractility, protein synthesis and genetic problems. In patients with alcoholic myopathies, multiorgan involvement is frequent and reversibility is only partially achieved by abstinence.
Muscle Research Group, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain.
J
J
Fernández-Solà
J M
JM
Junyent
A
A
Urbano-Márquez
D000208:Acute Disease; D000437:Alcoholism / Q000150:complications*; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D008928:Mitochondria / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D009135:Muscular Diseases / Q000209:etiology* / Q000503:physiopathology; D011379:Prognosis
D000431:Ethanol