Surgical therapy of primary cutaneous melanoma.
This review focuses on the surgical treatment of primary cutaneous melanoma. Interpretation of biopsy results and a rational approach to preoperative screening methods for metastases are examined. The marked changes in operative approach to melanoma over the past century are reviewed, with emphasis on the impact of prospective, randomized trials upon the width of surgical margins for melanoma. General principles of current surgical technique are discussed, with attention given to modifications of technique dictated by unique anatomic tumor sites.
Department of Surgery, University of Michigan Medical Center, Ann Arbor 48109, USA.
P J
PJ
Geraghty
T M
TM
Johnson
V K
VK
Sondak
A E
AE
Chang
D001706:Biopsy; D005500:Follow-Up Studies; D005528:Foot; D006225:Hand; D006258:Head and Neck Neoplasms / Q000601:surgery; D006801:Humans; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery*; D013933:Thumb; D013997:Time Factors; D014034:Toes