Photosensitization by anticancer agents 21: new perylene- and aminonaphthoquinones.
Hypocrellins are under intensive investigation as photosensitizing agents for photodynamic therapy (PDT). A recent advance in the synthesis of hypocrellin congeners resulted in the production of an amino-substituted hypocrellin-B, and its "half chromophore." Both compounds exhibit stronger red light absorption than previously reported hypocrellins, and, therefore, merit investigation as photosensitizers.
Organic Research, Molecular Probes, Inc., Eugene, OR, USA.
Z J
ZJ
Diwu
R P
RP
Haugland
J
J
Liu
J W
JW
Lown
G G
GG
Miller
R B
RB
Moore
K
K
Brown
J
J
Tulip
M S
MS
McPhee
D000818:Animals; D051379:Mice; D015394:Molecular Structure; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D010569:Perylene / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D019800:Phenol; D010778:Photochemotherapy; D011809:Quinones / Q000627:therapeutic use*; D014407:Tumor Cells, Cultured
D011809:Quinones; D019800:Phenol; D010569:Perylene; C048388:hypocrellin A