Regulation of the kynurenine pathway by IFN-gamma in murine cloned macrophages and microglial cells.
Pharma Division, Preclinical Research, Nervous System Diseases, F. Hoffmann La Roche Ltd. Basel, Switzerland.
D
D
Alberati-Giani
P
P
Ricciardi-Castagnoli
C
C
Köhler
A M
AM
Cesura
D050561:3-Hydroxyanthranilate 3,4-Dioxygenase; D000818:Animals; D001921:Brain / Q000201:enzymology; D002999:Clone Cells; D003907:Dexamethasone / Q000494:pharmacology; D049308:Dioxygenases; D004790:Enzyme Induction; D007371:Interferon-gamma / Q000494:pharmacology*; D007700:Kinetics; D007737:Kynurenine / Q000378:metabolism*; D050601:Kynurenine 3-Monooxygenase; D008070:Lipopolysaccharides / Q000494:pharmacology; D008190:Lyases; D008264:Macrophages / Q000187:drug effects / Q000201:enzymology*; D051379:Mice; D017628:Microglia / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010105:Oxygenases / Q000378:metabolism; D013950:Thymus Gland; D000637:Transaminases / Q000378:metabolism; D014366:Tryptophan Oxygenase / Q000096:biosynthesis*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D007737:Kynurenine; D003907:Dexamethasone; D007371:Interferon-gamma; D006899:Mixed Function Oxygenases; D010105:Oxygenases; D049308:Dioxygenases; D014366:Tryptophan Oxygenase; D050561:3-Hydroxyanthranilate 3,4-Dioxygenase; D050601:Kynurenine 3-Monooxygenase; D000637:Transaminases; C427605:glutamine - phenylpyruvate transaminase; C021481:kynurenine-oxoglutarate transaminase; D008190:Lyases