Torsades de pointes from terfenadine and sotalol given in combination.
A patient receiving sotalol developed recurrent torsades de pointes following the addition of terfenadine (Seldane) to her medical regimen. A 71-year-old woman with a history of atrial fibrillation successfully suppressed with sotalol, 80 mg bid, was started on terfenadine, 60 mg bid. Eight days later, she developed repeated self-terminating episodes of torsades de pointes. Sotalol and terfenadine were discontinued, and no further arrhythmia was observed after 72 hours of temporary pacing was discontinued.
Cardiology Division, John Dempsey Hospital, University of Connecticut Health Center, Farmington 06030, USA.
H
H
Feroze
R
R
Suri
D I
DI
Silverman
D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects; D001281:Atrial Fibrillation / Q000188:drug therapy; D004347:Drug Interactions; D004562:Electrocardiography; D005260:Female; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D013015:Sotalol / Q000008:administration & dosage / Q000009:adverse effects*; D016593:Terfenadine / Q000008:administration & dosage / Q000009:adverse effects*; D016171:Torsades de Pointes / Q000139:chemically induced* / Q000175:diagnosis
D000889:Anti-Arrhythmia Agents; D006634:Histamine H1 Antagonists; D016593:Terfenadine; D013015:Sotalol