Mice lacking alpha beta + T cells are resistant to the induction of experimental autoimmune encephalomyelitis.
T cells of the gamma delta subset have been found to localise to demyelinated lesions in both multiple sclerosis and experimental autoimmune encephalomyelitis (EAE) and have been implicated in the pathogenesis of both diseases. We have assessed mice carrying a targeted mutation of the T cell receptor-alpha locus which consequently lack T cell receptor (TCR) alpha beta cells but have an intact gamma delta(+)-T cell population for their susceptibility to EAE. No disease was found in any of the mutant mice, nor was any infiltration of the CNS detected. These data show that, at least in the absence of TCR-alpha beta cells. TCR-gamma delta cells are not able to elicit the pathology associated with EAE.
Section of Transplantation Biology, Clinical Research Centre, R.P.M.S., Hummersmith Hospital, London, UK.
J I
JI
Elliott
D C
DC
Douek
D M
DM
Altmann
D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D051379:Mice; D016688:Mice, Inbred NOD; D008815:Mice, Inbred Strains; D018345:Mice, Knockout; D004676:Myelin Basic Protein / Q000276:immunology; D010455:Peptides / Q000276:immunology; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000502:physiology*; D013116:Spinal Cord / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D004676:Myelin Basic Protein; D010455:Peptides; D016693:Receptors, Antigen, T-Cell, alpha-beta