Induction of Fos protein expression in spinal cord neurons by herpes simplex virus infections in the mouse.
After the inoculation of a highly attenuated strain of herpes simplex virus (HSV) type 1 into the mouse hind-paw planter skin, a few neurons and glial cells were viral antigen-positive in the dorsal root ganglia (DRGs) and anterior horn of L4 and L5 segments of the lumbar spinal cord. Fos-containing nuclei, however, were not found in the DRGs or the lumbar cord segments. After the inoculation of a highly neuroinvasive strain of HSV type 2, many virus-positive neurons and glial cells were detected in the DRGs, anterior and posterior horns at L4 and L5; Fos-containing nuclei were also observed in spinal neurons except for motoneurons. The results indicate that transneuronal infection of HSV induces Fos expression in spinal neurons.
Department of Anatomy, Fukushima Medical College, Japan.
N
N
Ozaki
Y
Y
Sugiura
M
M
Yamamoto
Y
Y
Nishiyama
D000818:Animals; D002522:Chlorocebus aethiops; D015967:Gene Expression Regulation, Viral; D006561:Herpes Simplex / Q000378:metabolism* / Q000821:virology; D018259:Herpesvirus 1, Human; D018258:Herpesvirus 2, Human; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009457:Neuroglia / Q000821:virology; D009474:Neurons / Q000378:metabolism* / Q000821:virology; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism* / Q000821:virology; D014709:Vero Cells
D016760:Proto-Oncogene Proteins c-fos