Praziquantel side effects during treatment of Schistosoma mansoni infected pupils in Kibwezi, Kenya.
Four hundred and thirty six pupils in two primary schools in Kibwezi, Kenya aged between seven and sixteen years and positive for S. mansoni were treated as follows: 320 pupils with a single dose of praziquantel at 40 mg/kg body weight and 116 controls with a placebo. Immediate and delayed side effects of praziquantel were observed. The main side-effects were abdominal pain (36.3%), headache (35.3%) and nausea (13.1%). There was correlation between frequencies of these side-effects and intensity of infection measured as eggs per gram of faeces. Other side-effects included dizziness (9.7%), fever (7.8%), urticaria and bloody diarrhoea. Overall, the side-effects of praziquantel were mild and transient, and did not require any intervention. For ethical reasons, all pupils who served as controls were treated with praziquantel after the study.
Department of Medical Microbiology, College of Health Sciences, University of Nairobi, Nairobi.
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WG
Jaoko
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Muchemi
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Oguya
D000293:Adolescent; D002648:Child; D005243:Feces / Q000469:parasitology; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006261:Headache / Q000139:chemically induced; D006801:Humans; D007630:Kenya; D008297:Male; D010270:Parasite Egg Count; D011223:Praziquantel / Q000009:adverse effects*; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000469:parasitology; D012556:Schistosomicides / Q000009:adverse effects*; D013334:Students
D012556:Schistosomicides; D011223:Praziquantel