Development of listeriosis during vancomycin therapy in a neutropenic patient.
Vancomycin and aminoglycosides are widely used for fever in neutropenic patients. This combination of antibiotics has also been proposed for the treatment of Listeria monocytogenes bacteremia. We report a case of fatal listeriosis in a 33-year-old man during acute lymphoblastic leukemia induction therapy in a total protective environment despite him having been on vancomycin for 8 days for treatment of staphylococcus bacteremia. Vancomycin and aminoglycoside cannot be proposed for the treatment of L. monocytogenes bacteria in neutropenic patients. Neutropenia might be a risk factor for listeriosis in cancer patients.
Service d'Oncologie Médicale, CHU Bretonneau, Tours, France.
O
O
Arsene
C
C
Linassier
R
R
Quentin
A
A
Legras
P
P
Colombat
D000328:Adult; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D008088:Listeriosis / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D009503:Neutropenia / Q000188:drug therapy* / Q000209:etiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000276:immunology; D014640:Vancomycin / Q000627:therapeutic use*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D014640:Vancomycin