Neutrophil activation by adhesion: mechanisms and pathophysiological implications.
Neutrophil adhesion plays an essential role in the formation of an inflammatory exudate. Moreover, adhesion activates selective neutrophil functions and regulates the cell response to additional stimuli. In this review we summarize the information available on adhesion molecules involved in neutrophil adhesion to endothelial cells and extracellular matrix proteins and the experimental approaches which have been developed to block neutrophil adhesion and neutrophil mediated tissue damage. We also address the mechanisms of activation of selective neutrophil functions by adhesion molecules and, in particular the mechanisms of signal transduction by neutrophil integrins. On the basis of recent results obtained in our and other laboratories we propose a model hypothesizing mechanisms of signaling by neutrophil integrins involved in regulation of selective functions.
Institute of General Pathology, University of Verona, Italy.
G
G
Berton
S R
SR
Yan
L
L
Fumagalli
C A
CA
Lowell
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D004730:Endothelium, Vascular / Q000502:physiology; D016326:Extracellular Matrix Proteins / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D016023:Integrins / Q000502:physiology; D008954:Models, Biological; D018375:Neutrophil Activation / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D017452:Receptors, IgG / Q000502:physiology; D019087:Selectins / Q000502:physiology; D015398:Signal Transduction
D015815:Cell Adhesion Molecules; D016326:Extracellular Matrix Proteins; D016023:Integrins; D017452:Receptors, IgG; D019087:Selectins; D011505:Protein-Tyrosine Kinases