Tachykinin NK2 receptor antagonists decrease eicosanoid release in lung anaphylaxis.
Two tachykinin NK2 receptor antagonists, MEN 10.627 c(Met-Asp-Trp-Phe-Dap-Leu) and MEN 10.376 [(Tyr5,Trp6,8,9,Lys10]neurokinin A-(4-10), were used to investigate the role of tachykinins in in vitro guinea-pig lung anaphylaxis. Both antagonists dose-dependently decreased bronchoconstriction and the release of thromboxane and prostaglandin E2 induced by antigen challenge in perfused sensitized lungs, but neither had any effect on the basal release of either eicosanoid. The findings indicated that tachykinins released by sensory nerve fibers may contribute to anaphylactic reactions by increasing arachidonic acid metabolite release.
Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Roma, Italy.
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D000707:Anaphylaxis / Q000378:metabolism; D000818:Animals; D016084:Bronchoconstriction; D015232:Dinoprostone / Q000096:biosynthesis / Q000378:metabolism* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D009130:Muscle, Smooth / Q000502:physiology; D015288:Neurokinin A / Q000031:analogs & derivatives* / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000494:pharmacology*; D018039:Receptors, Tachykinin / Q000502:physiology; D013929:Thromboxane B2 / Q000096:biosynthesis / Q000378:metabolism* / Q000502:physiology
D010446:Peptide Fragments; D010456:Peptides, Cyclic; D018039:Receptors, Tachykinin; C069192:neurokinin A(4-10), Tyr(5)-Trp(6,8,9)-Lys(10)-; C090951:MEN 10627; D013929:Thromboxane B2; D015288:Neurokinin A; D015232:Dinoprostone