Membrane bioelectrogenesis and ionic channel activity simulation under drug action.
The concept of the ionic channel, as a protein with more discrete ionic conductance levels, is analyzed and a computer program, aiming to simulate its dynamics under the action of a pharmacological agent, is presented. The binding of a pharmacological agent modifies the set of the possible configurations and the channel energy spectrum. Therefore it modifies the transition probabilities and the dwelling times in the excited (generally conductive) states. The program creates a library of simulations of the electric activity of some user designated hypothetical models. The simulations are then statistically compared to the recorded single channel events to select the most suitable model.
Faculté des Sciences Université Bretagne Occidentale, Brest France.
J P
JP
Pennec
A D
AD
Iacobas
S
S
Iacobas
D002462:Cell Membrane / Q000737:chemistry* / Q000378:metabolism; D003198:Computer Simulation; D004553:Electric Conductivity; D015640:Ion Channel Gating / Q000187:drug effects / Q000502:physiology*; D007473:Ion Channels / Q000187:drug effects* / Q000502:physiology; D008564:Membrane Potentials / Q000502:physiology; D008956:Models, Chemical
D007473:Ion Channels