Heterogeneity of eosinophils in chronic eosinophilic pneumonia.
It has previously been shown that patients with chronic eosinophilic pneumonia can be divided into 2 groups according to the chemotactic response of their eosinophils to 5 different eosinophil chemotactic factors (ECFs) and laboratory findings. In contrast, eosinophils obtained by bronchoalveolar lavage from both groups responded to all 5 ECFs. The correlation between the two groups and the expression of several antigens (VLA-4, CD69, ICAM-1 and CD11b) on eosinophils. The VLA-4 expression of group 1 eosinophils was higher than that of group 2 eosinophils. More interestingly, eosinophils that migrated towards ECF-PI9 expressed less CD69 than those that migrated towards other STO-2-derived ECF. The heterogeneous response of eosinophils to STO-2-derived ECFs suggests that the population of eosinophils is heterogeneous.
Department of Internal Medicine, Kumamoto University, Medical School, Japan.
N
N
Saita
T
T
Yamanaka
M
M
Sugimoto
H
H
Kohrogi
M
M
Suga
M
M
Ando
M
M
Hirashima
D015703:Antigens, CD / Q000378:metabolism; D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002631:Chemotactic Factors, Eosinophil / Q000502:physiology*; D002634:Chemotaxis, Leukocyte; D002908:Chronic Disease; D004804:Eosinophils / Q000473:pathology*; D006801:Humans; D039041:Integrin alpha4beta1; D016023:Integrins / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D037181:Lectins, C-Type; D016177:Macrophage-1 Antigen / Q000378:metabolism; D011657:Pulmonary Eosinophilia / Q000473:pathology*; D016201:Receptors, Lymphocyte Homing / Q000378:metabolism; D000099192:CD69 Antigens
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D015815:Cell Adhesion Molecules; D002631:Chemotactic Factors, Eosinophil; D039041:Integrin alpha4beta1; D016023:Integrins; D007770:L-Lactate Dehydrogenase; D037181:Lectins, C-Type; D016177:Macrophage-1 Antigen; D016201:Receptors, Lymphocyte Homing; D000099192:CD69 Antigens