Uptake of tetracycline in otoconia of the guinea pig.
Calcium ion turnover in the otoconia of adult guinea pigs was investigated by observing the uptake of tetracycline. Oral administration of tetracycline resulted in the deposition of tetracycline (fluorescence) on the outer surface of otoconia, indicating the occurrence of dynamic exchange and/or uptake of calcium ions in the otoconia. Prolonged administration of tetracycline induced with fluorescence deposition in the central portion as well as on the surface of the otoconia. These findings suggest the occurrence of neogenesis, regeneration and/or growth of otoconia even in adult animals.
Department of Otolaryngology, Hiroshima University School of Medicine, Japan.
D M
DM
Zhang
M
M
Takumida
Y
Y
Harada
D000818:Animals; D002118:Calcium / Q000378:metabolism; D005260:Female; D006168:Guinea Pigs; D008297:Male; D008856:Microscopy, Fluorescence; D010037:Otolithic Membrane / Q000254:growth & development / Q000378:metabolism* / Q000502:physiology; D012038:Regeneration; D013752:Tetracycline / Q000493:pharmacokinetics*; D013997:Time Factors
D013752:Tetracycline; D002118:Calcium