Immunohistochemical and virological study of skin in the papular-purpuric gloves and socks syndrome.
The pathogenesis of viral exanthems remains unclear. We have undertaken an immunohistochemical study of lesional skin biopsies in patients with the papular-purpuric gloves and socks syndrome (PPGSS) secondary to parvovirus B19 infection. Intracytoplasmic staining of the dermal endothelial cells, keratinocytes, and sweat glands was shown with an antibody to parvovirus B19. There were perivascular dermal infiltrates with T cells, sometimes with exocytosis. By polymerase chain reaction, virus DNA was detected in all skin biopsies and in one serum sample. The cutaneous manifestations of parvovirus infection seem secondary to infection of the endothelium and epidermis.
Unite de Dermatologie, Hôpital Tenon, Paris, France.
S
S
Aractingi
D
D
Bakhos
B
B
Flageul
O
O
Vérola
M
M
Brunet
L
L
Dubertret
F
F
Morinet
D000293:Adolescent; D000328:Adult; D000956:Antigens, Viral / Q000032:analysis; D001483:Base Sequence; D004279:DNA, Viral / Q000032:analysis; D016731:Erythema Infectiosum / Q000473:pathology / Q000821:virology*; D005260:Female; D005533:Foot Dermatoses / Q000473:pathology / Q000821:virology*; D006229:Hand Dermatoses / Q000473:pathology / Q000821:virology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D016732:Parvovirus B19, Human / Q000276:immunology / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction
D000956:Antigens, Viral; D004279:DNA, Viral