Studies on hyaluronidase, chondroitin sulphatase, proteinase and phospholipase secreted by Candida species.
We studied the ability of different Candida species to produce, at the same time, hyaluronidase, chondroitin sulphatase, proteinase, and phospholipase to assess whether they could be related to Candida pathogenicity. Only C. albicans was able to produce the four enzymes tested (73%) and was highly virulent to mice. Strains, that lack the capacity to produce one or more of the enzymes assayed, seemed less virulent or avirulent, similarly to the spontaneous hyaluronidase, chondroitin sulphatase, phospholipase and proteinase-deficient C. albicans strain FCF 14, 1 which was non-pathogenic to mice. Among the other Candida species tested, none of them produced the four enzymes simultaneously, being less virulent in intravenously inoculated mice.
Department of Pathology, School of Dentistry, Universidade Estadual Paulista Julio de Mesquita Filho UNESP, Säo José dos Campos, SP, Brazil.
M T
MT
Shimizu
N Q
NQ
Almeida
V
V
Fantinato
C S
CS
Unterkircher
D000818:Animals; D002175:Candida / Q000145:classification / Q000201:enzymology* / Q000472:pathogenicity*; D002176:Candida albicans / Q000145:classification / Q000201:enzymology / Q000472:pathogenicity; D002177:Candidiasis / Q000503:physiopathology*; D002808:Chondroitin Lyases / Q000096:biosynthesis*; D010450:Endopeptidases / Q000096:biosynthesis*; D006821:Hyaluronoglucosaminidase / Q000096:biosynthesis*; D007700:Kinetics; D051379:Mice; D010740:Phospholipases / Q000096:biosynthesis*; D013045:Species Specificity; D014774:Virulence
D010740:Phospholipases; D006821:Hyaluronoglucosaminidase; D010450:Endopeptidases; D002808:Chondroitin Lyases