Heterogeneous chemotactic response of eosinophils from patients with atopic dermatitis to eosinophil chemotactic factors.
The chemotactic response of eosinophils from 16 patients with atopic dermatitis (AD) to 5 eosinophil chemotactic factors (ECFs) were examined to clarify whether the response is associated with the clinical severity of AD. The factors included ECF-P15, -P16, -P17, -P18 and -P19 and were derived from a T cell line, STO-2. The patients were divided into 2 groups according to the percentage migration of eosinophils produced by the ECFs: a high-responding group (migration > 40%), and a low-responding group (migration < 30%). In a statistical analysis, eosinophils from patients with AD and atopic respiratory diseases (ARD) were found to be high-responding and those from patients with AD alone low-responding (p < 0.01). In a comparison of the chemotactic response of eosinophils from patients with AD alone at remission and at exacerbation, the percentage migrations in response to ECF-P15 and ECF-P16 at exacerbation were significantly higher than that at remission (p < 0.05). It is thus suggested that this type of heterogeneous response of eosinophils to STO-2-derived ECFs could provide a useful tool for evaluation of disease severity in patients with AD.
Department of Dermatology, Kagawa Medical School, Japan.
T
T
Yoshida
K
K
Fujita
M
M
Nishimoto
T
T
Takaiwa
M
M
Hirashima
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000150:complications; D002460:Cell Line; D002631:Chemotactic Factors, Eosinophil / Q000502:physiology*; D002634:Chemotaxis, Leukocyte; D003876:Dermatitis, Atopic / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications; D013601:T-Lymphocytes / Q000276:immunology
D002631:Chemotactic Factors, Eosinophil