Catecholamines inhibit alpha/beta interferon production induced by lipopolysaccharide.
In vitro incubation of Listeria monocytogenes immune spleen cells in the presence of the catecholamines epinephrine or norepinephrine inhibited the alpha/beta-interferon (IFN alpha/beta) synthesis induced by the mitogen lipopolysaccharide, in a manner that appeared to be concentration-dependent. Moreover, the inhibitory effect of both catecholamines epinephrine and norepinephrine on the synthesis of IFN alpha/beta was prevented by incubating immune spleen cells in the presence of propranolol, a beta-adrenergic antagonist agent.
Laboratorio de Immunología, Universidad de Guadalajara, Jal, Mexico.
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Andrade-Mena
D000818:Animals; D002395:Catecholamines / Q000494:pharmacology*; D002478:Cells, Cultured; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D016898:Interferon-alpha / Q000037:antagonists & inhibitors / Q000378:metabolism; D016899:Interferon-beta / Q000037:antagonists & inhibitors / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008089:Listeria monocytogenes / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009638:Norepinephrine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism
D002395:Catecholamines; D016898:Interferon-alpha; D008070:Lipopolysaccharides; D016899:Interferon-beta; D011433:Propranolol; D013936:Thymidine; D009638:Norepinephrine; D004837:Epinephrine