Selective cerebral hypothermia by means of transfemoral internal carotid artery catheterization.
Global cerebral hypothermia of 24 degrees C was induced without systemic cooling by means of selective hypothermic perfusion of a single internal carotid artery in four baboons. With a closed-circuit pump system, blood was withdrawn from the femoral artery, cooled in a water bath, and infused through an internal carotid artery catheter, which was positioned with fluoroscopic guidance. This endovascular technique may have applications in the treatment of neurologic disease in humans.
Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
A E
AE
Schwartz
J G
JG
Stone
J
J
Pile-Spellman
A D
AD
Finck
A A
AA
Sandhu
L B
LB
Mongero
R E
RE
Michler
D000818:Animals; D001921:Brain; D002343:Carotid Artery, Internal; D002406:Catheterization, Peripheral; D002560:Cerebrovascular Circulation; D005112:Extracorporeal Circulation; D005263:Femoral Artery; D005471:Fluoroscopy; D007036:Hypothermia, Induced / Q000379:methods*; D010215:Papio; D015641:Radiography, Interventional