No evidence of renal toxicity from amalgam fillings.
Dental amalgam continuously releases mercury. Studies of sheep [Boyd et al., Am. J. Physiol. 261 (Regulatory Integrative Comp. Physiol. 30): R1010-R1014, 1991] showed decreased renal function after placement of amalgam fillings. In this study, renal function was investigated in 10 healthy volunteers before and after amalgam removal. The subjects had an average of 18 tooth surfaces filled with amalgam, which was removed during one dental session. One week before and sixty days after removal, the glomerular filtration rate (GFR) was determined by 51Cr-EDTA clearance technique. Blood and urine samples were collected for analysis of mercury, creatinine, beta 2-microglobulin, N-acetyl-beta-glucosaminidase (NAG), and albumin 1 wk before and 1, 2, and 60 days after amalgam removal. The plasma mercury concentration increased significantly 1 day after removal. Sixty days later, significantly lower mercury levels were found in blood, plasma, and urine. The GFR values were similar before and after mercury exposure (mean 94 and 94 ml/min per 1.73 m2, respectively). No detectable effects occurred on excretion of NAG, beta 2-microglobulin, or albumin. It is concluded that no signs of renal toxicity could be found in conjunction with mercury released from amalgam fillings.
Department of Dental Toxicology, Karolinska Institute, Huddinge, Sweden.
G
G
Sandborgh-Englund
A T
AT
Nygren
J
J
Ekstrand
C G
CG
Elinder
D000118:Acetylglucosaminidase / Q000652:urine; D000328:Adult; D000419:Albuminuria / Q000652:urine; D003404:Creatinine / Q000378:metabolism; D003723:Dental Amalgam / Q000009:adverse effects*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008628:Mercury / Q000009:adverse effects* / Q000097:blood; D008875:Middle Aged; D013997:Time Factors; D001613:beta 2-Microglobulin / Q000652:urine
D001613:beta 2-Microglobulin; D003723:Dental Amalgam; D003404:Creatinine; D000118:Acetylglucosaminidase; D008628:Mercury