Hyperreninemia, hypertension, and congestive heart failure in focal interstitial nephritis.
Hyperreninemia probably due to focal interstitial nephritis of the right kidney caused an acute onset of hypertension and cardiac dysfunction including valvular insufficiency in a 5-year-old boy. This congestive heart failure in association with valvular insufficiency and hypertension was dramatically improved following right nephrectomy. Abruptly activated renin-angiotensin II may lead to congestive heart failure and valvular dysfunction without myocardial hypertrophy in a young heart.
Matsui
A
A
Department of Pediatrics, Shiga University of Medical Science, Japan.
Ono
K
K
Nakagawa
M
M
D001022:Aortic Valve Insufficiency; D002675:Child, Preschool; D015150:Echocardiography, Doppler; D004562:Electrocardiography; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000209:etiology*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology*; D007668:Kidney / Q000473:pathology*; D008297:Male; D009392:Nephrectomy; D009395:Nephritis, Interstitial / Q000097:blood / Q000150:complications* / Q000601:surgery; D012083:Renin / Q000097:blood*; D012084:Renin-Angiotensin System; D014057:Tomography, X-Ray Computed
D012083:Renin