Oral hairy leukoplakia in a patient with multiple myeloma.
The first case of oral hairy leukoplakia in an HIV-negative patient with multiple myeloma is reported. The patient is a 56-year old man who has had monoclonal gammopathy of undetermined significance since 1986 and has been treated for a symptomatic multiple myeloma since 1993. The clinical and histopathologic findings are typical for oral hairy leukoplakia, and Epstein-Barr virus was demonstrated with polymerase chain reaction technique. Although a relatively large number of cases of oral hairy leukoplakia has been reported in HIV-negative patients, both immunocompromised and immunocompetent, only a few of these patients have had a malignant hematologic disease.
Clinic of Oral Medicine, Ostra University Hospital, Göteborg, Sweden.
J
J
Blomgren
H
H
Bäck
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D004279:DNA, Viral / Q000032:analysis; D003907:Dexamethasone; D004317:Doxorubicin / Q000008:administration & dosage; D018023:HIV Seronegativity; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D016867:Immunocompromised Host; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D017733:Leukoplakia, Hairy / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D011994:Recombinant Proteins; D014750:Vincristine / Q000008:administration & dosage
D000998:Antiviral Agents; D004279:DNA, Viral; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin