Synthesis and antitumor activity of 1-[2-(chloroethyl)-3-(2-substituted-10H-phenothiazin-10-yl)alkyl- 1-urea s as potent anticancer agents.
10-[N-(Phthalimido)alkyl]-2-substituted-10H-phenothiazines and 1-(2-chloroethyl)-3-(2-substituted-10H-phenothiazin-10-yl)alkyl-1- ureas were synthesized and found to have antiproliferative effects on human HEp-2 and L5178Y cell cultures. The multi-drug resistant subline of mouse lymphoma was sensitive to the reversal effects of some 10-[N-(phthalimido)alkyl]-2-substituted-10H-phenothiazines, while 1-(2-chloro-ethyl)-3-(2-substituted-10H-phenothiazin-10-yl)alkyl-1 -ureas were less effective but had a similar degree of antiproliferative effect on both cell lines.
Department of Medicinal Chemistry, Meiji College of Pharmacy, Tokyo, Japan.
N
N
Motohashi
M
M
Kawase
T
T
Kurihara
A
A
Hevér
S
S
Nagy
I
I
Ocsocvszki
M
M
Tanaka
J
J
Molnár
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002460:Cell Line / Q000187:drug effects; D006801:Humans; D007940:Leukemia L5178 / Q000188:drug therapy; D051379:Mice; D010640:Phenothiazines / Q000138:chemical synthesis*; D010671:Phenylurea Compounds / Q000138:chemical synthesis*
D000970:Antineoplastic Agents; D010640:Phenothiazines; D010671:Phenylurea Compounds