[The activation processes of T-lymphocytes and their regulatory subpopulations in patients with pulmonary tuberculosis].
Immunophenotyping of lymphocytes by direct double-color immunofluorescence, investigation of metabolic activity of succinate dehydrogenase, alpha-glycerophosphate dehydrogenase, glucose-6-phosphate dehydrogenase, NAD- and NADP-diaphorases were performed in 77 tuberculous patients and 50 healthy donors. Activation of T-lymphocytes and their regulatory subpopulations is shown to depend on the extension of lung infiltration. At the same time, there were marked disorders in intracellular metabolism of peripheral blood lymphocytes. Close correlation exists between the activity of lymphocytic energy enzymes and the degree of expression on lymphocytes of receptors to interleukin-2, transferrin and HLA-DR-molecules. Cytochemical reactions for evaluation of blood lymphocyte energetic enzymes activity may be used in clinical practice for characterization of activation of T-lymphocytes and their regulatory subpopulations.
Mishin
V Iu
VIu
Pavliuk
A S
AS
Koval'chuk
L V
LV
D000328:Adult; D015703:Antigens, CD / Q000097:blood; D000944:Antigens, Differentiation, B-Lymphocyte / Q000097:blood; D017252:CD3 Complex / Q000097:blood; D016516:CD4-CD8 Ratio; D006684:HLA-DR Antigens / Q000097:blood; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000097:blood; D011990:Receptors, Transferrin; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000276:immunology*
D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D017252:CD3 Complex; C068126:CD71 antigen; D006684:HLA-DR Antigens; D015375:Receptors, Interleukin-2; D011990:Receptors, Transferrin