Plasmalogen-selective phospholipase A2 and its role in signal transduction.
The breakdown of plasmalogens in neural membranes is a receptor-mediated process catalyzed by a plasmalogen-selective phospholipase A2. This enzyme has been isolated from bovine brain. It is localized in cytosol and does not require Ca2+ for its activity. It has a molecular weight of 39 kDa and is strongly inhibited by glycosaminoglycans, gangliosides and sialoglycoproteins. The interactions between plasmalogen-selective phospholipase A2 and glycoconjugates may be involved in the regulation of enzymic activity. Under normal conditions, plasmalogen-selective phospholipase A2 provides second messengers such as arachidonic acid and eicosanoids. However, under pathological conditions, this enzyme may be involved in a massive release of free fatty acids that may cause serious cell and tissue damage.
Department of Medical Biochemistry, Ohio State University, Columbus 43210, USA.
H C
HC
Yang
A A
AA
Farooqui
L A
LA
Horrocks
D000818:Animals; D002417:Cattle; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D009474:Neurons / Q000378:metabolism*; D010741:Phospholipases A / Q000378:metabolism*; D054467:Phospholipases A2; D010955:Plasmalogens / Q000378:metabolism*; D015398:Signal Transduction
D010955:Plasmalogens; D010741:Phospholipases A; D054467:Phospholipases A2