Functional significance of alterations in cardiac contractile protein isoforms.
Multiple closely related, yet distinct, isoforms exist for each of the cardiac contractile proteins. The isoform composition of the heart changes in response to developmental and physiologic cues. This paper reviews the molecular basis for cardiac contractile protein isoform diversity and the functional consequences of isoform shifts.
Department of Medicine (Cardiology), Albert Einstein College of Medicine, New York, USA.
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Kitsis
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Scheuer
D000818:Animals; D003285:Contractile Proteins / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000502:physiology; D009200:Myocardial Contraction / Q000502:physiology; D009206:Myocardium / Q000378:metabolism*; D011817:Rabbits
D003285:Contractile Proteins