B non-Hodgkin's lymphoma in a haemophilia patient with idiopathic CD4+ T-lymphocytopenia.
We report here a case of an HIV-uninfected, anti-hepatitis C virus (HCV) positive haemophiliac, who was transfused with blood and intermediate purity factor VIII concentrates. Since 1988, a progressive decline in the CD4+ T-cell count was recorded, and in 1993 a B-cell non-Hodgkin's lymphoma (B-NHL) was diagnosed. The morphological appearance of the tumor with features of intermediate/mantle zone lymphoma, and the absence of EBV sequences within the tumor, ruled out the occurrence of a typical "opportunistic" lymphoma. However it is possible that the blood product therapy and its infectious complications may have played a role on immune function impairment.
Institute of Medical Semeiotics, University of Padua Medical School, Padova, Italy.
R
R
Paolini
E
E
D'Andrea
A
A
Poletti
A
A
Del Mistro
P
P
Zerbinati
A
A
Girolami
D000328:Adult; D015703:Antigens, CD / Q000097:blood; D001402:B-Lymphocytes / Q000737:chemistry / Q000473:pathology; D006467:Hemophilia A / Q000150:complications* / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008297:Male; D016612:Paraffin Embedding; D012307:Risk Factors; D018344:T-Lymphocytopenia, Idiopathic CD4-Positive / Q000150:complications* / Q000276:immunology / Q000473:pathology
D015703:Antigens, CD