[The functional activity of class-I and -II HLA antigens in pulmonary tuberculosis].
The paper presents evaluation of HLA-system functional activity in patients with pulmonary tuberculosis and bronchial asthma by expression of class I and II antigens and beta2-microglobulin level in peripheral blood cell elements. Tuberculous patients had reduced production of beta2-microglobulin in the cell elements. Long-term chemotherapy aggravated the above abnormality. A correlation was found between changes in the cell elements expressing HLA antigens class I and II and tuberculosis course. Lowered lymphocyte count expressing HLA antigens class I and II occurs in progression of tuberculosis and is associated with marked depression of T-cell immunity.
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RP
Selitskaia
Iu Iu
IuIu
Ponomareva
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000276:immunology; D002908:Chronic Disease; D015395:Histocompatibility Antigens Class I / Q000097:blood*; D000949:Histocompatibility Antigens Class II / Q000097:blood*; D006801:Humans; D007111:Immunity, Cellular; D008875:Middle Aged; D012008:Recurrence; D013601:T-Lymphocytes / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000276:immunology*; D001613:beta 2-Microglobulin / Q000032:analysis
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D001613:beta 2-Microglobulin