Prognostic significance of pathological chest radiography in transplant patients affected by cytomegalovirus and/or pneumocystis carinii.
OBJECTIVE
In order to evaluate the prognostic significance of chest film findings in connection with cytomegalovirus (CMV) and/or pneumocystis carinii infection (PC), a retrospective review was made of the pulmonary charts of 274 recipients of kidney and/or pancreatic grafts transplanted between April 1987 and December 1990.


RESULTS
Positive laboratory findings for CMV and/or PC were seen in 92 patients. In 77 patients only CMV was found, 13 patients had both CMV and PC, and 2 patients had only PC. In 57 patients a chest examination was performed. The films were reviewed by 2 radiologists independently. In 32 patients normal chest film findings were seen, while 25 patients demonstrated pathological changes. Of the patients with pathological changes 3 had only pleuritis while the remaining 22 demonstrated parenchymal infiltrations. No deaths occurred among patients infected with CMV and/or PC, when the chest film findings were normal or pleuritis only was seen, but there were 9 deaths in the group of patients with parenchymal infiltrations. Of the patients who died, 2 had only CMV, 5 had both CMV and PC, and 2 had only PC. The overall mortality, regardless of radiological findings, did not exceed 3% in patients with CMV only, but increased to 38% in patients with both CMV and PC. In patients with parenchymal infiltrations the corresponding mortality figures were increased to 18% and 56%, respectively.


CONCLUSIONS
We conclude that a radiologically verified pneumonia related to the infectious agent influences the prognosis, and that CMV pneumonia has a better prognosis than PC pneumonia.
Department of Transplantation Surgery, Karolinska Hospital, Stockholm, Sweden.
B
B
Wilczek
H E
HE
Wilczek
N
N
Heurlin
G
G
Tydén
P
P
Aspelin
D003586:Cytomegalovirus Infections / Q000000981:diagnostic imaging* / Q000401:mortality; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016030:Kidney Transplantation / Q000000981:diagnostic imaging*; D016035:Pancreas Transplantation / Q000000981:diagnostic imaging*; D011020:Pneumonia, Pneumocystis / Q000000981:diagnostic imaging* / Q000401:mortality; D011024:Pneumonia, Viral / Q000000981:diagnostic imaging* / Q000401:mortality; D011183:Postoperative Complications / Q000000981:diagnostic imaging* / Q000382:microbiology / Q000401:mortality; D011379:Prognosis; D011859:Radiography; D012189:Retrospective Studies