[Glucose intolerance in chronic renal failure].
It has been recognized that glucose intolerance is a common finding in patients with chronic renal failure (CRF). Insulin resistance and impaired insulin secretion contribute to the pathogenesis of glucose intolerance. The resistance to insulin action is commonly observed in chronic renal failure and mainly due to impaired glucose uptake by muscle. In contrast, insulin secretion in response to hyperglycemia is variable: increased, decreased and normal. Recent studies reported that high PTH levels impaired insulin secretion from pancreatic islets. In this review, we mention the mechanism of glucose intolerance in chronic renal failure.
Matsushita
Y
Y
Toranomon Hospital Kidney Center.
Hara
S
S
D018149:Glucose Intolerance / Q000209:etiology*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D000078790:Insulin Secretion; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000503:physiopathology; D010281:Parathyroid Hormone / Q000378:metabolism / Q000502:physiology
D007328:Insulin; D010281:Parathyroid Hormone