Zinc, cadmium, and mercury complexes of 5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine (dmtp). Preparation, spectroscopic characterization, and biological activity. X-ray crystal structures of [Zn(dmtp)2Br2], [Hg(dmtp)2Cl2], and [Hdmtp]2[CdBr4]. 2H2O.
The preparation and spectroscopic characterization of a series of dmtp complexes of Zn, Cd, and Hg, where dmtp is 5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidine, is reported. Crystal structure analyses of [Zn(dmtp)2Br2] and [Hg(dmtp)2Cl2] reveal distorted tetrahedral geometries about the central atoms and the dmtp ligands to coordinate via the N(3) atom exclusively. In the X-ray structure of [Hdmtp]2[CdBr4].2H2O, the [Hdmtp]+ cation is protonated at the N(3) atom, there being no significant interaction between Hdmtp and cadmium. A study of the antimicrobial activity of the complexes shows that the [Cd(dmtp)X2(OH2)] (X = Cl, Br) compounds display activity against two strains.
Salas
J M
JM
Departamento de Química Inorgánica, Facultad de Ciencias, Universidad de Granada, Spain.
Romero
M A
MA
Rahmani
A
A
Faure
R
R
Alvarez de Cienfuegos
G
G
Tiekink
E R
ER
D002104:Cadmium / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008628:Mercury / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D014192:Trapidil / Q000031:analogs & derivatives* / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
D002104:Cadmium; C046931:5,7-dimethyl-(1,2,4)triazolo(1,5-a)pyrimidine; D014192:Trapidil; D008628:Mercury; D015032:Zinc