Endogenous Mtv-encoded superantigens are not required for development of murine AIDS.
Immune activation in murine AIDS (MAIDS) has been suggested to involve a superantigen (SAG). The possibility that SAGs encoded by mammary tumor virus (MTV) might be the source of stimulation was studied by using Mtv mice. Mtv- mice developed typical MAIDS, excluding a requirement for Mtv-encoded SAGs in the pathogenesis of this disorder.
McCarty
T C
TC
Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.
Chattopadhyay
S K
SK
Scherer
M T
MT
Fredrickson
T N
TN
Hartley
J W
JW
Morse
H C
HC
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D002460:Cell Line; D005260:Female; D009052:Leukemia Virus, Murine / Q000276:immunology*; D008297:Male; D008324:Mammary Tumor Virus, Mouse / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D016183:Murine Acquired Immunodeficiency Syndrome / Q000276:immunology*; D018089:Superantigens / Q000276:immunology*
D000956:Antigens, Viral; D018089:Superantigens