Enantiospecific synthesis and in vitro activity of selective inhibitors of rat brain kynureninase and kynurenine-3-hydroxylase.
Pharmacia, R&D-CNS, Nerviano Milano, Italy.
A
A
Giordani
L
L
Corti
M
M
Cini
R
R
Bormetti
M
M
Marconi
O
O
Veneroni
C
C
Speciale
M
M
Varasi
D000409:Alanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001565:Benzoates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001921:Brain / Q000201:enzymology*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006867:Hydrolases / Q000037:antagonists & inhibitors*; D007202:Indicators and Reagents; D007700:Kinetics; D050601:Kynurenine 3-Monooxygenase; D008297:Male; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors*; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D001565:Benzoates; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D006899:Mixed Function Oxygenases; D050601:Kynurenine 3-Monooxygenase; D006867:Hydrolases; C021480:kynureninase; D000409:Alanine