Hemodynamic effects of cardiomyoplasty in an experimental model of acute heart failure and atrial fibrillation.
The aim of our work was to study the hemodynamic effects of dynamic cardiomyoplasty on an acute animal model of atrial fibrillated heart failure. Eight anesthetized open chest dogs suffering from atrial fibrillation and heart failure, obtained by topic acetylcholine and propranolol, were treated by a cardiomyoplasty procedure performed with an electrostimulated latissimus dorsi muscle flap (LDMF). Values considered for analysis during LDMF stimulation were selected from cardiac cycles with R-R intervals similar to those when the LDMF was not stimulated (+/- 20 ms). Atrial fibrillated heart failure showed a significant increase of systemic vascular resistance, end diastolic left ventricular pressure (EDLVP) and right atrial pressure (p < 0.05), and a significant decrease in cardiac output, systolic left ventricular pressure (SLVP), and mean aortic pressure (p < 0.05) compared with control values. LDMF stimulation in atrial fibrillated heart failure resulted in a significant increase of SLVP, cardiac output, and mean aortic pressure (p < 0.05) and a significant decrease of systemic vascular resistance, EDLVP, and right atrial pressure (p < 0.05) compared with nonstimulated values. The highest LVP values were obtained with R-R intervals long enough to allow an adequate LV filling. We conclude that dynamic cardiomyoplasty provides an appropriate recovery in this animal model of atrial fibrillated heart failure. Cardiomyoplasty is an appropriate procedure for cardiac assist when R-R intervals allow an adequate LV filling.
Basic Research Center, University Institute of Biomedical Sciences, Favaloro Foundation, Buenos Aires, Argentina.
E I
EI
Cabrera Fischer
J C
JC
Chachques
A I
AI
Christen
M R
MR
Risk
A
A
Carpentier
D000109:Acetylcholine / Q000633:toxicity; D000818:Animals; D001281:Atrial Fibrillation / Q000139:chemically induced / Q000601:surgery*; D001794:Blood Pressure / Q000502:physiology*; D002302:Cardiac Output / Q000502:physiology*; D018421:Cardiomyoplasty; D004195:Disease Models, Animal; D004285:Dogs; D004558:Electric Stimulation; D005260:Female; D006333:Heart Failure / Q000139:chemically induced / Q000601:surgery*; D008297:Male; D011433:Propranolol / Q000633:toxicity; D016896:Treatment Outcome; D014655:Vascular Resistance / Q000502:physiology*; D016277:Ventricular Function, Left / Q000502:physiology
D011433:Propranolol; D000109:Acetylcholine