Neuroendocrine changes in chronic cardiac failure.
Numerous hormonal and neuroendocrine changes have been described in patients with chronic cardiac failure. These affect the balance of vasodilator and vasoconstrictor factors in favour of the latter, to the detriment of the circulation. Whether this is a reaction to central cardiac (haemodynamic) abnormalities, or is an integral part of the syndrome of heart failure, remains to be determined. Catecholamine levels are increased, especially in severe heart failure, and contribute to the vasoconstriction and probably also to lethal ventricular arrhythmias. The renin-angiotensin-aldosterone system (RAAS) is also activated, causing fluid retention and further vasoconstriction. In the earlier stages, some of this increase may be iatrogenic due to the use of loop diuretics or inhibitors of angiotensin converting enzyme, but there is evidence for independent RAAS activation in more severe grades of heart failure. The role of vasoconstrictor peptides such as neuropeptide Y and endothelin is briefly considered. Counterbalancing these are vasodilator peptides, in particular atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP). The possibility of therapeutic interventions to increase circulating natriuretic hormone levels is discussed.
Nicholls
D P
DP
Department of Medicine, Royal Victoria Hospital, Northern Ireland.
Onuoha
G N
GN
McDowell
G
G
Elborn
J S
JS
Riley
M S
MS
Nugent
A M
AM
Steele
I C
IC
Shaw
C
C
Buchanan
K D
KD
D009320:Atrial Natriuretic Factor / Q000097:blood; D001839:Bombesin / Q000097:blood; D002908:Chronic Disease; D005934:Glucagon / Q000097:blood; D006333:Heart Failure / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D007328:Insulin / Q000097:blood; D009478:Neuropeptide Y / Q000097:blood; D009490:Neurosecretory Systems / Q000503:physiopathology*; D009496:Neurotensin / Q000097:blood; D012084:Renin-Angiotensin System
D007328:Insulin; D009478:Neuropeptide Y; D009496:Neurotensin; D009320:Atrial Natriuretic Factor; D005934:Glucagon; D001839:Bombesin