Evolution of Hodgkin's disease.
Hodgkin's disease is an oncogenic core disorder characterized by both mitotic and amitotic neoplastic multiplication, and is associated with collateral disorders such as lacunar formation and leukocytic infiltration. Research has demonstrated that Hodgkin's disease progresses stepwise, beginning with a reversible, biological stage during which Hodgkin and Reed-Sternberg cells are formed, followed by constitutive, but reversible Hodgkinogenic medical stage that leads to an irreversible, systemic and fatal proto-oncogenic stage. This disease results from collateral activation of cytokine and archaic oncogenes, suppression of DNA repair genes in multiple chromosomes. The variability of Hodgkin's disease manifestations has required antisynthetic (antimetabolites, radiotherapy), anti-viral (acyclovir) and anti-mitotic (vincristine, vinblastine) for different loci minores of treatment. Continued molecular biological research of the ancestral and prokaryotic oncogenes is recommended.
Department of Radiology, Tohoku Rosai Hospital, Sendai, Japan.
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Okuyama
D005075:Biological Evolution; D002455:Cell Division; D004260:DNA Repair / Q000235:genetics; D005786:Gene Expression Regulation; D006689:Hodgkin Disease / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D006801:Humans; D008938:Mitosis; D008954:Models, Biological; D009154:Mutation; D009857:Oncogenes; D016539:Reed-Sternberg Cells / Q000473:pathology