Effect of inhalation of chamomile oil vapour on plasma ACTH level in ovariectomized-rat under restriction stress.
We found that inhaling chamomile oil vapour decreased restriction stress-induced increases of plasma ACTH level in ovariectomized rat. The plasma ACTH level decreased further when diazepam was administered along with inhaling chamomile oil vapour. Flumazenile blocked the decrease in plasma ACTH level induced by inhaled chamomile oil vapour.
Tokyo University of Pharmacy and Life Science, School of Pharmacy, Tokyo, Japan.
K
K
Yamada
T
T
Miura
Y
Y
Mimaki
Y
Y
Sashida
D000280:Administration, Inhalation; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology; D003975:Diazepam / Q000037:antagonists & inhibitors / Q000494:pharmacology; D005260:Female; D005442:Flumazenil / Q000494:pharmacology; D018757:GABA Modulators / Q000494:pharmacology; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010052:Ovariectomy; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000097:blood*
D014151:Anti-Anxiety Agents; D018757:GABA Modulators; D006993:Hypnotics and Sedatives; D010938:Plant Oils; D005442:Flumazenil; D000324:Adrenocorticotropic Hormone; D003975:Diazepam