Hepatic and cerebrospinal fluid accumulation of aluminium and bismuth in volunteers taking short course anti-ulcer therapy.
To investigate the possible absorption and deposition of bismuth or aluminium from agents used in the treatment of peptic ulcers, we have measured levels of bismuth and aluminium in the liver tissue of 15 patients undergoing elective liver biopsy and in the cerebrospinal fluid (CSF) of 15 patients undergoing elective myelography after administration of standard therapeutic doses of tripotassium dicitrato bismuthate (TBS), sucralfate or aluminium hydroxide for 1 month. Aliquots of liver or CSF were separated and levels of both aluminium and bismuth were assayed in each sample by atomic absorption spectrophotometry. The group who received TBS had significantly higher liver bismuth levels than the other two treatment groups, but there was no significant difference in CSF bismuth levels among the three groups. There was no significant difference in either liver or CSF aluminium levels among the three treatment groups. We conclude that tissue accumulation of bismuth may occur after short-course therapy with colloidal bismuth, although there is no evidence of CNS accumulation of bismuth in the present study.
Department of Gastroenterology, Auckland Public Hospital, New Zealand.
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E
Gane
M M
MM
Sutton
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J
Pybus
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I
Hamilton
D000535:Aluminum / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D000536:Aluminum Hydroxide / Q000493:pharmacokinetics / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001706:Biopsy; D001729:Bismuth / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009192:Myelography; D009942:Organometallic Compounds / Q000493:pharmacokinetics / Q000627:therapeutic use; D013392:Sucralfate / Q000493:pharmacokinetics / Q000627:therapeutic use; D013997:Time Factors
D000897:Anti-Ulcer Agents; D009942:Organometallic Compounds; D013392:Sucralfate; D000536:Aluminum Hydroxide; D000535:Aluminum; C002791:bismuth tripotassium dicitrate; D001729:Bismuth