Differential binding of Nocardia asteroides in the murine lung and brain suggests multiple ligands on the nocardial surface.
The adherence of Nocardia asteroides in the murine brain and lungs was determined. Virulent strains had increased adherence in the brain and lungs, whereas less virulent strains bound in either the brain or lungs. Nocardiae that attached apically penetrated host cells. Multiple receptors on the nocardial surface may be involved in this differential attachment and penetration.
Department of Medical Microbiology and Immunology, University of California School of Medicine, Davis 95616, USA.
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Beaman
D000818:Animals; D001422:Bacterial Adhesion; D001921:Brain / Q000382:microbiology*; D015169:Colony Count, Microbial; D006801:Humans; D008168:Lung / Q000382:microbiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009616:Nocardia asteroides / Q000472:pathogenicity* / Q000502:physiology; D011650:Pulmonary Alveoli / Q000382:microbiology; D014774:Virulence