Left ventricular gas emboli in six cases of altitude-induced decompression sickness.
BACKGROUND
Ultrasonic techniques have demonstrated venous gas emboli (VGE) during exposure to high altitude. VGE per se have not been considered clinically hazardous. Arterial gas emboli (AGE), however, are viewed with great concern. The crossing-over of venous gas to the arterial circulation has not previously been seen in human subjects at altitude. This transfer may occur via either intracardiac defects, pulmonary shunts, or the pulmonary microcirculation.


METHODS
A non-invasive ultrasonic echo imaging Doppler system was used to monitor volunteer human subjects for gas emboli simultaneously in the right and left sides of the heart at simulated altitude in a chamber. Subjects found to have gas cross-over were evaluated for septal defects with either transthoracic or transesophageal echocardiography.


RESULTS
Previously unreported left ventricular gas emboli were observed with echo imaging in six subjects at altitude. In all six cases, at the time of AGE onset, the VGE scores were high from all monitored sites. Three subjects had no septal defect, another had a small sinus venosus defect, a third had a patent foramen ovale, and one was not available for evaluation. Five of the cases became symptomatic at the time of AGE onset.


CONCLUSIONS
Operational altitude exposures known to elicit high VGE counts in the majority of people should be avoided because of an increased risk of right-to-left gas cross-over and resulting potential for severe cerebral symptomatology.
Pilmanis
A A
AA
Armstrong Laboratory (AFMC), Crew Systems Directorate, Crew Technology Division, San Antonio, TX 78235-5104, USA.
Meissner
F W
FW
Olson
R M
RM
D000337:Aerospace Medicine / Q000379:methods; D000531:Altitude; D001164:Arteriovenous Fistula / Q000150:complications*; D003665:Decompression Sickness / Q000503:physiopathology*; D004618:Embolism, Air / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006344:Heart Septal Defects, Atrial / Q000150:complications* / Q000000981:diagnostic imaging; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D014463:Ultrasonography