Results of large penetrating keratoplasty in microbial keratitis.
Extensive corneal disease secondary to microbial keratitis can result in frank or impending corneal perforation requiring a large penetrating keratoplasty. In an 8-year period, 26 penetrating keratoplasties with recipient beds of > or = 9.5 mm were performed on 22 eyes: 11 for bacterial keratitis, 10 for fungal keratitis, and one for a mixed bacterial and fungal keratitis. The graft failed in 18 of 19 eyes (94.7%), with a median time to failure of 12.9 weeks in bacterial keratitis and 4.0 weeks in fungal keratitis. After large keratoplasty, 17 of 20 eyes (85.0%) maintained the structural integrity of the globe. The remainder became phthisical or required enucleation. With preservation of the structural integrity of the globe, a subsequent smaller optical penetrating keratoplasty is an option in some of these eyes.
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Florida, USA.
S M
SM
Cristol
E C
EC
Alfonso
J H
JH
Guildford
T J
TJ
Roussel
W W
WW
Culbertson
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003320:Corneal Ulcer / Q000382:microbiology* / Q000601:surgery*; D015818:Eye Infections, Bacterial / Q000209:etiology / Q000601:surgery*; D015821:Eye Infections, Fungal / Q000209:etiology / Q000601:surgery*; D005260:Female; D006085:Graft Survival; D006801:Humans; D015948:Keratoplasty, Penetrating; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014792:Visual Acuity