Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium.
Conventional major histocompatibility complex (MHC) class I genes encode molecules that present intracellular peptide antigens to T cells. They are ubiquitously expressed and regulated by interferon gamma. Two highly divergent human MHC class I genes, MICA and MICB, are regulated by promoter heat shock elements similar to those of HSP70 genes. MICA encodes a cell surface glycoprotein, which is not associated with beta 2-microglobulin, is conformationally stable independent of conventional class I peptide ligands, and almost exclusively expressed in gastrointestinal epithelium. Thus, this MHC class I molecule may function as an indicator of cell stress and may be recognized by a subset of gut mucosal T cells in an unusual interaction.
Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA 98104, USA.
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V
Groh
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Bahram
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S
Bauer
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Herman
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Beauchamp
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T
Spies
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D002460:Cell Line; D004064:Digestive System / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D005805:Genes, MHC Class I; D006360:Heat-Shock Proteins / Q000235:genetics* / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D008856:Microscopy, Fluorescence; D011401:Promoter Regions, Genetic; D014162:Transfection
D002352:Carrier Proteins; D006360:Heat-Shock Proteins; D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A; C098080:MICB antigen