Primaquine analogues that are potent anti-Trypanosoma cruzi agents in a mouse model.
Seventy-seven primaquine analogues were evaluated for their effectiveness in reducing the parasitaemias in female albino mice (aged 4-6 weeks) which had been infected with a Brazilian strain of Trypanosoma cruzi 15 days earlier. Of the analogues tested, 23 were more effective than the reference drug, nifurtimox, and one was > 14-fold as effective as the standard and almost four times as active as primaquine itself. Certain members of the series tested warrant further evaluation.
Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC 20307-5100, USA.
K E
KE
Kinnamon
B T
BT
Poon
W L
WL
Hanson
V B
VB
Waits
D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy*; D002626:Chemistry, Pharmaceutical; D005260:Female; D051379:Mice; D011319:Primaquine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014349:Trypanosoma cruzi
D014344:Trypanocidal Agents; D011319:Primaquine