Sensitization to the locomotor activating effects of cocaine following cocaethylene-preexposure.
The present study assessed the ability of cocaethylene to induce sensitization to the behavioral activating effects of cocaine in the male Sprague-Dawley rat. Preexposure to cocaethylene (15 or 25 mg/kg) significantly enhanced the locomotor activating effects of a subsequent cocaine (15 mg/kg) challenge injection. In addition, acute intraperitonecal administration at several doses (10, 15, or 25 mg/kg) confirmed previous reports of increased bioavailability of cocaine in brain and plasma relative to cocaethylene. These data are discussed in terms of previous work in which a significant augmentation of cocaine-induced locomotor activity was not observed following cocaethylene preexposure.
Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520-8066, USA.
B A
BA
Horger
J R
JR
Taylor
J D
JD
Elsworth
P I
PI
Jatlow
R H
RH
Roth
D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D003042:Cocaine / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D018765:Dopamine Uptake Inhibitors / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D004347:Drug Interactions; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D017072:Neostriatum / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012680:Sensitivity and Specificity
D018765:Dopamine Uptake Inhibitors; C066444:cocaethylene; D003042:Cocaine