Therapeutic effect of oral Kalanchoe pinnata leaf extract in murine leishmaniasis.
The effect of a leaf extract from Kalanchoe pinnata (Kp) was investigated in BALB/c mice infected with Leishmania amazonensis. Oral treatment with Kp significantly delayed onset of disease as compared to untreated mice or mice receiving Kp by the intravenous or topical routes. When initiated at early stages of infection, daily oral doses of 8 mg prevented lesion growth and the effect was long-lasting, comparable to the reference antileishmanial drug Glucantime. The decreased lesion growth using the oral route was accompanied by a significant decrease in the number of viable parasites. Protection was accompanied by a diminished capacity of animals to develop delayed-type hypersensitivity and to produce specific antibodies.
Da Silva
S A
SA
Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil.
Costa
S S
SS
Mendonca
S C
SC
Silva
E M
EM
Moraes
V L
VL
Rossi-Bergmann
B
B
D000284:Administration, Oral; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D006968:Hypersensitivity, Delayed; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007896:Leishmaniasis / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal
D007166:Immunosuppressive Agents; D010936:Plant Extracts