Effects of caloric restriction and source of dietary carbohydrate on glycemic status of the Fischer 344 rat.
The effects of caloric restriction and dietary carbohydrate source on the regulation of insulin secretion were evaluated in vivo and using islets of Langerhans isolated from 9-month-old male Fischer 344 rats. Serum glucose and insulin concentrations of rats fed a calorie-restricted diet for 6 months were significantly less than those of rats fed ad libitum, regardless of carbohydrate source. Rats fed diets containing fructose, either as a monosaccharide or as a component of a disaccharide, had generally greater serum insulin and glucose concentrations than rats fed diets containing no fructose. Glucose-stimulated insulin secretion by islets isolated from rats fed the restricted diet was significantly less than those of rats fed ad libitum. No differences in islet insulin secretion associated with carbohydrate source were observed. These results suggest that caloric restriction and the source of dietary carbohydrate can have significant effects on the glycemic status of the rat.
Ruhe
R C
RC
Department of Nutrition, University of California, Davis 95616, USA.
Coordt
M C
MC
McDonald
R B
RB
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001835:Body Weight; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D019422:Dietary Sucrose / Q000008:administration & dosage; D002149:Energy Intake; D005508:Food Deprivation; D005632:Fructose / Q000008:administration & dosage; D005947:Glucose / Q000008:administration & dosage; D066298:In Vitro Techniques; D007328:Insulin / Q000097:blood / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D019422:Dietary Sucrose; D007328:Insulin; D005632:Fructose; D005947:Glucose