Increased sodium appetite and thirst in rat induced by the ingredients of liquorice, glycyrrhizic acid and glycyrrhetinic acid.
In the rat, blocking 11 beta-OHSD with the active ingredient of liquorice, glycyrrhizic acid (GZA) or its hydrolytic product, 18 beta-glycyrrhetinic acid (GTA), caused potassium loss, increased water intake and a primary increase in salt appetite that was specific for sodium and not secondary to sodium loss. Intracerebroventricular injection of angiotensin II enhanced the sodium appetite but carbachol did not. The stimulating effects of GZA or GTA on intakes of water and NaCl resembled those caused by the administration of excessive amounts of mineralocorticoid. The results suggest that GZA- or GTA-induced drinking behaviour is mediated by circulating glucocorticoids. After liquorice blockade of 11 beta-OHSD, the peripheral and central mineralocorticoid receptors are no longer protected from glucocorticoid action.
Physiological Laboratory, Cambridge, UK.
A S
AS
Cooney
J T
JT
Fitzsimons
D000804:Angiotensin II / Q000008:administration & dosage; D000818:Animals; D001069:Appetite Regulation / Q000187:drug effects / Q000502:physiology*; D010367:Arachis / Q000737:chemistry; D002217:Carbachol / Q000008:administration & dosage; D004326:Drinking / Q000187:drug effects / Q000502:physiology*; D006034:Glycyrrhetinic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006035:Glycyrrhiza / Q000737:chemistry*; D019695:Glycyrrhizic Acid; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D008297:Male; D000074241:Peanut Oil; D010938:Plant Oils / Q000008:administration & dosage; D010946:Plants, Medicinal; D011188:Potassium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012462:Saline Solution, Hypertonic; D012964:Sodium / Q000378:metabolism; D012965:Sodium Chloride / Q000008:administration & dosage*; D013894:Thirst / Q000187:drug effects / Q000502:physiology*
D000074241:Peanut Oil; D010938:Plant Oils; D012462:Saline Solution, Hypertonic; D000804:Angiotensin II; D012965:Sodium Chloride; D019695:Glycyrrhizic Acid; D002217:Carbachol; D012964:Sodium; D006034:Glycyrrhetinic Acid; D011188:Potassium