Iron accumulation in tissues of magnesium-deficient rats with dietary iron overload.
The mineral imbalances in magnesium-deficient rats with dietary iron overload were studied. Forty-four male Wistar rats were divided into six groups and fed six diets, two by three, fully crossed: magnesium adequate or deficient, and iron deficient, adequate, or excess. The concentrations of iron, magnesium, calcium, and phosphorus in tissues of the rats were measured. The results were as follows: (1) The excess iron intake reinforced the iron accumulation in liver and spleen of magnesium deficient rats; (2) The saturation of iron binding capacity was enormously elevated in the magnesium deficient rats fed excess iron; and (3) Dietary iron deprivation diminished the degree of calcium deposition in kidney of magnesium deficient rats. These results suggest that magnesium-deprived rats have abnormal iron metabolism losing homeostatic regulation of plasma iron, and magnesium deficient rats with dietary iron overload may be used as an experimental hemochromatosis model.
Department of Social Medicine, Graduate School of Medicine, Kyoto University, Konoecho Yoshida Sakyoku, Japan.
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Kimura
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Yokoi
D000704:Analysis of Variance; D000818:Animals; D001827:Body Height / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D004032:Diet; D004195:Disease Models, Animal; D004435:Eating / Q000502:physiology; D005527:Food, Fortified; D006432:Hemochromatosis / Q000209:etiology; D007501:Iron / Q000008:administration & dosage / Q000097:blood*; D008275:Magnesium Deficiency / Q000097:blood*; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
D010281:Parathyroid Hormone; D010758:Phosphorus; D007501:Iron; D002118:Calcium