Decreased neurotrophin-3 expression in skeletal muscles of streptozotocin-induced diabetic rats.
The expression of neurotrophin-3 (NT-3) in skeletal muscles was measured in rats with streptozotocin (STZ)-induced diabetes using Northern blot analysis. At 6 weeks after STZ induction of diabetes, the NT-3 mRNA level in the quadriceps and gastrocnemius muscles was decreased by 45 and 77%, respectively, compared with that in age-matched controls. Since NT-3 is considered to be essential for the maintenance of spinal proprioceptive afferent neurons, decreased NT-3 expression in target tissues would impair the integrity of afferent neurons and might be an earlier marker in the sensory neuronal damage observed in diabetes mellitus.
Ihara
C
C
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan.
Shimatsu
A
A
Mizuta
H
H
Murabe
H
H
Nakamura
Y
Y
Nakao
K
K
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D015536:Down-Regulation; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism*; D009414:Nerve Growth Factors / Q000096:biosynthesis*; D020933:Neurotrophin 3; D051381:Rats; D017208:Rats, Wistar; D015854:Up-Regulation
D009414:Nerve Growth Factors; D020933:Neurotrophin 3