Significance of serum tissue inhibitor of metalloproteinases-1 in various liver diseases.
OBJECTIVE
This study was performed to assess the significance of elevated serum tissue inhibitor of metalloproteinases-1 concentration in various liver diseases.


METHODS
Tissue inhibitor of metalloproteinases-1 levels were measured in patients with various liver diseases, and were compared with serum type III procollagen-N-peptide (P III P), type IV collagen and laminin P1 levels, as well as with the histology of liver biopsy specimens.


RESULTS
Mean tissue inhibitor of metalloproteinases-1 levels were significantly higher in subjects with acute viral hepatitis, cirrhosis, alcoholic hepatitis, and alcoholic cirrhosis than in the control group (p < 0.05). Serum tissue inhibitor of metalloproteinases-1 levels in the various liver diseases showed positive correlation with serum type IV collagen, P III P, and laminin P1 levels. Regarding the relationship between tissue inhibitor of metalloproteinases-1 and liver histology, serum tissue inhibitor of metalloproteinases-1 levels correlated with the degree of hepatic fibrosis and inflammation, such as focal necrosis and cell infiltration. Furthermore, elevated serum tissue inhibitor of metalloproteinases-1 levels were especially related to the cell infiltration, focal necrosis, portal fibrosis, and serum type IV collagen level.


CONCLUSIONS
These findings suggest that the measurement of the serum tissue inhibitor of metalloproteinases-1 level in various liver diseases may be useful to estimate the active hepatic fibrogenesis associated with the active inflammatory stage of the liver injury.
Second Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan.
T
T
Ueno
S
S
Tamaki
H
H
Sugawara
S
S
Inuzuka
T
T
Torimura
M
M
Sata
K
K
Tanikawa
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003094:Collagen / Q000097:blood; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D007797:Laminin / Q000097:blood; D008107:Liver Diseases / Q000097:blood* / Q000201:enzymology; D008297:Male; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood; D011347:Procollagen / Q000097:blood; D011480:Protease Inhibitors / Q000097:blood*; D012044:Regression Analysis; D019714:Tissue Inhibitor of Metalloproteinases
D015415:Biomarkers; D006023:Glycoproteins; D007797:Laminin; D010446:Peptide Fragments; D011347:Procollagen; D011480:Protease Inhibitors; D019714:Tissue Inhibitor of Metalloproteinases; C055716:laminin P1; C041876:procollagen Type III-N-terminal peptide; D003094:Collagen; D008666:Metalloendopeptidases