Treatment of T3 and T4 carcinomas of the gallbladder.
Forty-nine patients with T3 and T4 carcinoma of the gallbladder were treated by three different regimens. Group 1 consisted of 26 patients treated with combined resection alone; group 2 was twelve patients whose tumors had spread to the hepatoduodenal ligament treated with combined resection plus intraoperative radiation therapy; group 3 comprised eleven patients with nonresectable tumors treated with hyperthermia in combination with chemoradiation therapy (HCRT). The difference in the survival rates between group 1 and 2 were statistically significant (p < 0.001); however, the difference between group 2 and 3 was not significant. In group 1, there was a significant difference between patients with and without lymph node involvement in the 3-year survival rate (p < 0.01). Thus, the only patients without involvement of regional lymph nodes and the hepatoduodenal ligament have the best potential for long-term survival through aggressive surgical approaches. HCRT may provide an alternative palliation for patients with advanced carcinoma showing obstructive jaundice.
Okamoto
A
A
Department of Surgery, Tokyo Metropolitan Komagome Hospital, Japan.
Tsuruta
K
K
Ishiwata
J
J
Isawa
T
T
Kamisawa
T
T
Tanaka
Y
Y
D000368:Aged; D002758:Cholangiography; D003131:Combined Modality Therapy; D005260:Female; D005706:Gallbladder Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D015996:Survival Rate; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome