Ocular-motor delayed-response task performance among schizophrenia patients.
Twenty schizophrenia patients and 20 nonpsychiatric subjects were presented with an ocular-motor delayed-response task. Schizophrenia patients generated fewer memory-guided saccades which were characterized by increased latency and decreased gain relative to the nonpsychiatric subjects. In addition, the patients generated an increased frequency of reflexive (made to the initial cue) and anticipatory (made during the delay period) errors. The results are most consistent with hypothesized pathology of prefrontal cortex among schizophrenia patients.
Department of Psychology, University of California, San Diego 92093-0109, USA.
J E
JE
McDowell
B A
BA
Clementz
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D012438:Saccades / Q000502:physiology*; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013647:Task Performance and Analysis