Repopulation of Langerhans cells during wound healing in an experimental human skin/SCID mouse model.
The epidermal repopulation of Langerhans cells (LCs) during wound healing was examined using a human skin severe combined immunodeficient (SCID) mouse model. The experiments, were carried out after proving the human origin of keratinocytes repopulating the wound beds using the W6/32 monoclonal antibody. It was shown that CD1a- and HLA-DR-positive dendritic cells (mostly LCs) are already detectable 2 days after injury within the newly formed epithelium. In the excisional wounds investigated, neither HLA-DR nor ICAM-1 expression of human keratinocytes was observed. Our present data suggest that LC repopulation is an early event in the process of re-epithelization.
Juhász
I
I
Department of Dermatology, University Medical School Debrecen, Debrecen, Hungary.
Simon
M
M
Herlyn
M
M
Hunyadi
J
J
D000818:Animals; D004195:Disease Models, Animal; D004848:Epithelium / Q000473:pathology; D006684:HLA-DR Antigens / Q000378:metabolism; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D007801:Langerhans Cells / Q000276:immunology / Q000473:pathology*; D051379:Mice; D016513:Mice, SCID; D012867:Skin / Q000276:immunology / Q000293:injuries* / Q000473:pathology; D016038:Skin Transplantation; D013997:Time Factors; D014183:Transplantation, Heterologous; D014945:Wound Healing / Q000276:immunology / Q000502:physiology*
D006684:HLA-DR Antigens; D018799:Intercellular Adhesion Molecule-1