Hyperphagia induced by direct administration of midazolam into the parabrachial nucleus of the rat.
Benzodiazepine receptor agonists increase food intake in many different species, yet there has been little investigation of the central site of actions of these drugs on ingestive behaviour. In the present experiments, direct administration of the benzodiazepine receptor agonist midazolam (3-30 micrograms/microliter) into the parabrachial nucleus of the pons significantly increased the consumption of a wet mash diet and a 3% sucrose solution in adult non-deprived rats. The hyperphagic response was blocked by pre-treatment with the selective benzodiazepine receptor antagonist flumazenil. Injection of midazolam into the parabrachial nucleus had no effect on locomotor activity, despite the fact that in the same animals an increase in mash intake was observed following intra-parabrachial midazolam. These data suggest that benzodiazepine receptors located in the parabrachial nucleus may be an important site of action for the effects of benzodiazepines specifically on ingestive behaviour.
Department of Psychology, University of Durham, UK.
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Higgs
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Cooper
D000704:Analysis of Variance; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D002552:Cerebral Ventricles / Q000033:anatomy & histology; D005247:Feeding Behavior / Q000187:drug effects*; D005442:Flumazenil / Q000494:pharmacology*; D018757:GABA Modulators / Q000494:pharmacology*; D006963:Hyperphagia / Q000139:chemically induced*; D007276:Injections, Intraventricular; D008297:Male; D008874:Midazolam / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D011149:Pons / Q000187:drug effects*; D051381:Rats; D013395:Sucrose
D014151:Anti-Anxiety Agents; D018757:GABA Modulators; D005442:Flumazenil; D013395:Sucrose; D008874:Midazolam