Molecular basis of T lymphocyte CD4 antigen functions.
The T cell surface antigen CD4 plays a pivotal role in the MHC class II-restricted response of specific T lymphocytes and serves as the major receptor of human immunodeficiency viruses (HIV). Recent studies have shown the high complexity of CD4 functions in physiological and pathological conditions. We report here a short review of recent developments in the field and discuss the structural features which regulate the functions mediated by the CD4 coreceptor in mature T lymphocytes.
UPR 420 CNRS, Villejuif, France.
M
M
Gaubin
M
M
Autiero
R
R
Houlgatte
S
S
Basmaciogullari
C
C
Auffray
D
D
Piatier-Tonneau
D001665:Binding Sites; D015704:CD4 Antigens / Q000737:chemistry / Q000502:physiology*; D015699:HIV Envelope Protein gp120 / Q000378:metabolism*; D015497:HIV-1; D000949:Histocompatibility Antigens Class II / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular
D015704:CD4 Antigens; D015699:HIV Envelope Protein gp120; D000949:Histocompatibility Antigens Class II