Pharmacological and histopathological aspects of 1-methyl-4-phenyl-4-hydroxy-piperidine (MPIP).
Increasing dosages of 1-methyl-4-phenyl-4-hydroxypiperidine (MPIP) were administered i.p. to rats. Histopathological examination of these animals revealed effects on the central nervous system.
Dipartimento Farmaco Chimico--Facoltà di Farmacia di Bari, Italy.
S
S
Bruno
N
N
DeLaurentis
M A
MA
Milillo
G
G
Tantillo
A
A
Perillo
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000473:pathology; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D008297:Male; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats
C103304:1-methyl-4-phenyl-4-hydroxypiperidine; D002491:Central Nervous System Agents; D010880:Piperidines