Eosinophils negatively regulate eosinophilopoiesis by decreasing IL-5 levels.
The effect of mature eosinophils on eosinophilopoiesis was studied. Mature eosinophils decreased the interleukin-5 (IL-5) level after incubation with IL-5 and suppressed IL-5 release from non-adherent mononuclear cells. These findings suggest that eosinophils negatively regulate eosinophilopoiesis by decreasing the IL-5 level.
Third Department of Internal Medicine, Dokkyo University School of Medicine, Tochigi, Japan.
H
H
Enokihara
T
T
Koike
Y
Y
Nakamura
K
K
Yamashiro
N
N
Tsuruoka
K
K
Saito
S
S
Furusawa
D004802:Eosinophilia / Q000503:physiopathology; D004804:Eosinophils / Q000502:physiology*; D005260:Female; D015870:Gene Expression; D006410:Hematopoiesis; D006801:Humans; D015848:Interleukin-5 / Q000502:physiology*; D008297:Male; D012333:RNA, Messenger / Q000235:genetics; D018123:Receptors, Interleukin / Q000235:genetics*; D053649:Receptors, Interleukin-5; D011994:Recombinant Proteins / Q000494:pharmacology
D015848:Interleukin-5; D012333:RNA, Messenger; D018123:Receptors, Interleukin; D053649:Receptors, Interleukin-5; D011994:Recombinant Proteins