AIDS lymphoma.
Most AIDS-related non-Hodgkin's lymphomas can be categorized into one of three histologic subtypes: large-cell immunoblastic, small non-cleaved cell (Burkitt's or Burkitt's-like) and diffuse large cell. Rare histologies include Ki-1 anaplastic large cell lymphoma, angiotropic large cell lymphoma, mucosa-associated lymphoid tissue, primary pulmonary T-cell lymphoma, and Sézary syndrome. Although the role of Epstein-Barr virus remains uncertain, a new herpes virus, human herpes virus 8, has been identified in the rare subset of effusion-based lymphomas. Overexpression of the cytokines interleukin-6 and interleukin-10 may have a role in pathogenesis, and they may serve as potential therapeutic targets. In addition, chronic antigenic stimulation may correlate with elevated serum CD22 levels and may serve as a tool for early detection. Novel investigational therapies in clinical development include new chemotherapy-based regimens, immune modulators, antibody therapy, as well as cellular therapy.
Sandler
A S
AS
University of California, AIDS Program, San Francisco General Hospital 94110, USA.
Kaplan
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L
D000970:Antineoplastic Agents / Q000627:therapeutic use; D016207:Cytokines / Q000502:physiology; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007167:Immunotherapy; D016483:Lymphoma, AIDS-Related / Q000209:etiology / Q000235:genetics / Q000276:immunology / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology / Q000235:genetics / Q000276:immunology / Q000628:therapy
D000970:Antineoplastic Agents; D016207:Cytokines; D004791:Enzyme Inhibitors; D007155:Immunologic Factors