A straightforward synthesis of 3 alpha- and 3 beta-aminodigoxigenin.
Pure 3 alpha- and 3 beta-aminodigoxigenin were previously prepared from 12-acetyldigoxigenin by a multistep route involving tosylation, azide inversion, deprotection, and reduction. This paper describes the straightforward synthesis of the pure epimers in a single step via reductive amination of digoxigenone and chromatographic separation without the need for protection and deprotection.
Adamczyk
M
M
Department of Chemistry, Abbott Diagnostics Division, Abbott Laboratories, Abbott Park, Illinois 60064, USA.
Grote
J
J
D002845:Chromatography; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004076:Digoxigenin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy
C104157:3-aminodigoxigenin; D004076:Digoxigenin