Fructose-1,6-diphosphate: potential protection in cyclosporine-induced renal impairment.
There is evidence that fructose-1,6-diphosphate (FDP) provides protection from hepatic and cardiac toxic-induced damage and ischemic renal insult. To determine if FDP also protects against cyclosporine (CsA)-induced nephrotoxicity, two groups of adult male Wistar rats were studied for whole kidney clearance rates. After two initial control periods, group 1 received only CsA (CsA, n = 8). Group 2 received FDP 350 mg/kg, followed by CsA 50 mg/kg (FDP-CsA, n = 6). In both groups, after a 30-min equilibration period, two additional clearance rates were measured (Post 1 and Post 2). A significant reduction in clearance rates was observed after drug infusion in both groups (approximately 58 and 64% in CsA and FDP-CsA groups, respectively, p < 0.05) with a recovery to control values in the Post 2 period in the FDP-CsA group. These data suggest a protective effect of FDP on CsA-induced renal impairment.
Cardoso
L R
LR
Nephrology Division, Universidade Federal do Rio de Janeiro, Brazil.
Santos
O F
OF
Boim
M A
MA
Barros
E G
EG
Ajzen
H
H
Schor
N
N
D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology / Q000633:toxicity*; D005635:Fructosediphosphates / Q000494:pharmacology*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007155:Immunologic Factors / Q000494:pharmacology; D007511:Ischemia / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012079:Renal Circulation / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D005635:Fructosediphosphates; D007155:Immunologic Factors; D016572:Cyclosporine; C029063:fructose-1,6-diphosphate