Variational (Lagrangian) approach to myeloid differentiation path(s).
Concepts from Lagrangian variationals are adapted to rationalize both statistics and evolution of certain non-holonomic gene rearrangements in certain leukemias (such as chronic myeloid leukemia) as well as in a significant proportion of healthy individuals.
USC Medical School, Los Angeles 90033, USA.
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Matioli
D002454:Cell Differentiation; D015321:Gene Rearrangement; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics; D008957:Models, Genetic; D015233:Models, Statistical; D012016:Reference Values