Afferents originating from the dorsal penile nerve excite oxytocin cells in the hypothalamic paraventricular nucleus of the rat.
Electrical stimulation of the dorsal penile nerve (DPN) produced orthodromic excitation in about half of oxytocin cells in the paraventricular nucleus (PVN). In contrast, less than 10% of vasopressin cells were excited. Tactile stimulation of the glans penis by a paintbrush produced excitation in 40% of oxytocin cells. Castration did not prevent activation of oxytocin cells. These results suggest that somatosensory information from the penis is transmitted to the PVN through the DPN and that such afferent input preferentially innervates oxytocin cells.
Department of Anesthesiology and Reanimatology, Fukui Medical School, Japan.
M
M
Yanagimoto
K
K
Honda
Y
Y
Goto
H
H
Negoro
D000344:Afferent Pathways / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation; D007839:Functional Laterality; D008297:Male; D009474:Neurons / Q000502:physiology*; D009919:Orchiectomy; D010121:Oxytocin / Q000502:physiology*; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology*; D010413:Penis / Q000294:innervation*; D010525:Peripheral Nerves / Q000502:physiology*; D010812:Physical Stimulation; D010902:Pituitary Gland / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D014110:Touch
D010121:Oxytocin