Decreased myocardial oxygen consumption indices in dynamic cardiomyoplasty.
BACKGROUND
To investigate the theory of decreased myocardial oxygen consumption (MVo2) in dynamic cardiomyoplasty (DCM), previous studies have calculated indices of MVo2 in DCM. These previous studies, however, used left ventricular pressure in formulas that assumed the assumed the heart to be in its native state, with the reference pressure at the epicardium assumed to be atmospheric. In DCM, however, the reference pressure at the epicardium is no longer atmospheric but rather is the compressive pressure generated by the latissimus dorsi (LD). We therefore used the transmural myocardial pressure, Pt, to calculate indices of MVo2 in DCM.


RESULTS
A half-ellipsoidal, fluid-filled balloon was interposed between the LD and myocardium in a balloon-mediated cardiomyoplasty procedure in five goats. With commonly used LD stimulation parameters, Pt was calculated as left ventricular pressure minus balloon luminal pressure. Using Pt, the transmural tension time index (TtTI) and transmural pressure volume area (PtVA) were calculated. In another series of four goats, LD stimulation parameters were optimized and the TtTI and PtVA recalculated. With standard LD stimulation parameters, the TtTI decreased by 48%, from 15.8 to 8.2 mm Hg.s, and the PtVA by 21%, from 775 to 612 mm Hg.mL, as the LD was stimulated to contract. When the optimized parameters were used, the TtTI decreased by 45%, from 11.2 to 6.2 mm Hg.s, and the PtVA by 33%, from 1984 to 1371 mm Hg.mL.


CONCLUSIONS
Our results suggest that DCM with a fluid-filled balloon decreases MVo2 as the LD contracts and that LD stimulation parameters have a determining effect on this benefit.
Division of Applied Sciences, Harvard Graduate School of the Arts and Sciences, Cambridge, Mass, USA.
F Y
FY
Chen
B J
BJ
deGuzman
L
L
Aklog
D B
DB
Lautz
R M
RM
Ahmad
R G
RG
Laurence
G S
GS
Couper
L H
LH
Cohn
T A
TA
McMahon
D000818:Animals; D018421:Cardiomyoplasty; D006041:Goats; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption