Potentiation of LSD-induced stimulus control by fluoxetine in the rat.
The present investigation examined the interaction between fluoxetine enantiomers and LSD in rats trained with LSD as a discriminative stimulus. The dose response relationships for LSD alone and in combination with either (+)- or (-)-fluoxetine were determined. In both instances, the LSD dose response relationship was shifted to the left. However, statistical significance was observed only for the (+)- enantiomer. It is concluded that the effects of LSD as a discriminative stimulus are potentiated by the acute administration of fluoxetine. These results are consistent with anecdotal reports of interactions between LSD and acutely administered SSRIs in humans.
Fiorella
D
D
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo 14214-3000, USA.
Helsley
S
S
Rabin
R A
RA
Winter
J C
JC
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004347:Drug Interactions; D005473:Fluoxetine / Q000737:chemistry / Q000494:pharmacology*; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D013237:Stereoisomerism
D005473:Fluoxetine; D008238:Lysergic Acid Diethylamide