Prenatal and postpartum pharmacokinetics of stavudine (2',3'-didehydro-3'-deoxythymidine) and didanosine (dideoxyinosine) in pigtailed macaques (Macaca nemestrina).
Stavudine (5 mg/kg of body weight; n = 7) or didanosine (3.2 mg/kg; n = 4) was administered as an intravenous bolus to pregnant pigtailed macaques (Macaca nemestrina) near term and 4 to 5 weeks postpartum. No significant differences were found between the prenatal and postpartum total plasma drug clearance, steady-state volume of distribution, terminal plasma drug half-life, mean body residence time, or recovery of unchanged drug in urine. These data indicate that pregnancy does not affect the pharmacokinetics of stavudine or didanosine in M. nemestrina.
Department of Pharmaceutics, University of Washington, Seattle 98195, USA.
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Odinecs
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Pereira
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Nosbisch
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Unadkat
D000818:Animals; D000831:Animals, Newborn; D019380:Anti-HIV Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D016049:Didanosine / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D005260:Female; D006207:Half-Life; D007262:Infusions, Intravenous; D008254:Macaca nemestrina; D049590:Postpartum Period / Q000378:metabolism*; D011247:Pregnancy; D018119:Stavudine / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
D019380:Anti-HIV Agents; D018119:Stavudine; D016049:Didanosine