Development and testing of a revised dynamic model of radiocaesium transfer to sheep tissues.
The model of radiocaesium transfer to sheep presented by Galer et al. provides reliable predictions only for sheep of a similar body weight to those used in the development of the model (approximately 30 kg). To extend the applicability of the model, it was necessary to re-parameterise it in terms of activity concentrations in tissues rather than total activities within them (although for gut compartments the use of activity has been retained). The rate coefficients for the new model have been estimated by fitting the model to the data used by Galer et al. which was derived from a single "calibration" experiment. The new model was found to account for 94% of the observed variation in the data (n = 42), a result similar to that obtained by Galer et al. The model has also been tested against data not used in its development but obtained from four separate experiments undertaken by three different laboratories. Good agreement between the predictions of the new model and observations was found for most circumstances and for several breeds of sheep with different body weights. It is concluded that the new model provides a useful dynamic description of radiocaesium transfers to the tissues of sheep of different breeds and under different contamination scenarios.
Department of Physiology and Environmental Science, University of Nottingham, Sutton Bonington, UK. Neil.Crout@Nottingham.ac.uk
N M
NM
Crout
N A
NA
Beresford
B J
BJ
Howard
R W
RW
Mayes
P A
PA
Assimakopoulos
C M
CM
Vandecasteele
D000284:Administration, Oral; D000818:Animals; D002588:Cesium Radioisotopes / Q000378:metabolism*; D003198:Computer Simulation; D005507:Food Contamination, Radioactive; D008954:Models, Biological; D009928:Organ Specificity; D012756:Sheep
D002588:Cesium Radioisotopes