Explaining discrepant mortality results between primary percutaneous transluminal coronary angioplasty and thrombolysis for acute myocardial infarction.
Differing relative outcomes in randomized versus registry studies comparing primary angioplasty with thrombolytic therapy for acute myocardial infarction suggest a clinical paradox. A predictive model based on differences in 5 treatment-related factors, including time to therapy, patency success, and angioplasty experience, suggests that relative outcomes may indeed vary, depending on the clinical setting in which therapy is given.
J L
JL
Anderson
L A
LA
Karagounis
J B
JB
Muhlestein
D000465:Algorithms; D015906:Angioplasty, Balloon, Coronary / Q000401:mortality*; D017052:Hospital Mortality; D006801:Humans; D009203:Myocardial Infarction / Q000401:mortality* / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic; D012042:Registries; D015912:Thrombolytic Therapy / Q000401:mortality*; D013997:Time Factors; D016896:Treatment Outcome