Enzymatic synthesis of two isoxazolylalanine isomers by cysteine synthases in Lathyrus species.
Two isoxazolylalanine isomers, beta-(isoxazolin-5-on-2-yl)-L-alanine (BIA, 1) and beta-(isoxazolin-5-on-4-yl)-L- alanine (TAN-950A, 2) were confirmed to be derived from O-acetyl-L-serine (OAS) and isoxazolin-5-one by cysteine synthases (CSases) with a different ratio in different plant parts. Some properties of this enzyme in the biosynthesis of both isomers are described.
Faculty of Pharmaceutical Sciences, Chiba University, Japan.
F
F
Ikegami
M
M
Kamiya
Y H
YH
Kuo
F
F
Lambein
I
I
Murakoshi
D000409:Alanine / Q000031:analogs & derivatives* / Q000378:metabolism; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003547:Cysteine Synthase / Q000378:metabolism*; D007887:Fabaceae / Q000201:enzymology*; D006863:Hydrogen-Ion Concentration; D007536:Isomerism; D007555:Isoxazoles / Q000378:metabolism*; D007700:Kinetics; D010946:Plants, Medicinal; D013056:Spectrophotometry, Ultraviolet
D007555:Isoxazoles; C103992:beta-(isoxazolin-5-on-4-yl)alanine; C074507:(isoxazolin-5-on-2-yl)alanine; D003547:Cysteine Synthase; D000409:Alanine