Resolving polyhydramnios: clinical significance and subsequent neonatal outcome.
The objective of this study was to determine the clinical significance and neonatal outcome of patients with polyhydramnios that subsequently resolved prior to delivery. A retrospective review of 275 cases of polyhydramnios, defined as an amniotic fluid index of > or = 25.0 cm, identified 41 cases in which the amniotic fluid volume returned to normal prior to delivery. A total of 40 out of 41 patients with resolving polyhydramnios had a mild to moderate excess of amniotic fluid. There was a significant difference in the distribution of neonatal delivery weights between the study group and a matched control group. Twelve of 41 (29.3%) neonates from the study vs. none of the neonates in the control group were large for gestational age (p < 0.001). A total of 21 of 41 patients (51.2%) in the study group vs. three of 41 (7.3%) patients in the control group had at least minimal glucose intolerance (p < 0.01). We conclude that patients with resolving polyhydramnios have a significantly higher prevalence of glucose intolerance and fetal macrosomia than patients with normal pregnancies.
Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Women's Hospital, Pittsburgh, PA, USA.
L M
LM
Hill
N
N
Lazebnik
A
A
Many
J G
JG
Martin
D000293:Adolescent; D000328:Adult; D000653:Amniotic Fluid; D001724:Birth Weight; D005260:Female; D005320:Fetal Macrosomia / Q000503:physiopathology*; D005865:Gestational Age; D018149:Glucose Intolerance / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D006831:Polyhydramnios / Q000175:diagnosis / Q000503:physiopathology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors