An XXYY male with schizophrenia.
OBJECTIVE
A case of XXYY associated with schizophrenia is presented.


METHODS
A European male with tall stature, hypogonadism, and mild grade intellectual handicap with significantly lower verbal than performance Intelligence Quotient (IQ) exhibited features of chronic paranoid schizophrenia, along with impulsive aggression.


RESULTS
A trial of testosterone replacement exacerbated aggression. Psychotic symptoms persisted despite antipsychotic therapy.


CONCLUSIONS
This is perhaps the first report of the XXYY syndrome associated with schizophrenia. The psychosis occurs more often in XXY and XXX than normal subjects, providing a clue to locating a gene predisposing to schizophrenia.
Graylands Hospital, Mt Claremont, Australia.
J W
JW
Lee
D000328:Adult; D000374:Aggression / Q000523:psychology; D006801:Humans; D008607:Intellectual Disability / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D007621:Karyotyping; D008297:Male; D010641:Phenotype; D012563:Schizophrenia, Paranoid / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D014960:X Chromosome; D014998:Y Chromosome