Antigen Ki-67 and c-myc oncogene as related to histoclinical parameters in pigmented skin lesions.
121 cases of cutaneous melanomas, 82 lymph nodes with melanoma metastases and 62 naevi were stained immunohistochemically for presence of Ki-67 antigen and c-myc oncogene. A significant correlation between expression of investigated markers, and survival time as well as presence of metastases, in cutaneous melanomas was found (p < 0.05). The role of Ki-67 antigen for differential diagnosis between naevi and melanomas is also demonstrated.
Department of Pathology, Georg-August University Göttingen, Germany.
M
M
Korabiowska
U
U
Brinck
J
J
Mirecka
S
S
Kellner
D
D
Marx
A
A
Schauer
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D016259:Genes, myc / Q000235:genetics*; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000556:secondary; D008875:Middle Aged; D009367:Neoplasm Staging; D009506:Nevus / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D012878:Skin Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate
D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen