Inhibitory effect of Di- and trihydroxy triterpenes from the flowers of compositae on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice.
Ten dihydroxy- and trihydroxy triterpenes, viz., four taraxastanes: faradiol, heliantriol B0, heliantriol C and arnidiol; two lupanes: calenduladiol and heliantriol B2; two oleananes: maniladiol and longispinogenin; and two ursanes: brein and uvaol, isolated from the nonsaponifiable lipids of the flower extracts of Compositae plants were evaluated with respect to their anti-inflammatory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. All the triterpenes were found to possess marked inhibitory activity. The 50% inhibitory dose of these compounds with respect to TPA-inflammation (1 microgram) was 0.03-0.2 mg/ear.
College of Pharmacy, Nihon University, Chiba, Japan.
K
K
Yasukawa
T
T
Akihisa
H
H
Oinuma
Y
Y
Kasahara
Y
Y
Kimura
S
S
Yamanouchi
K
K
Kumaki
T
T
Tamura
M
M
Takido
D000818:Animals; D007249:Inflammation / Q000139:chemically induced*; D051379:Mice; D010944:Plants; D013755:Tetradecanoylphorbol Acetate / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D014315:Triterpenes / Q000138:chemical synthesis* / Q000494:pharmacology
D014315:Triterpenes; D013755:Tetradecanoylphorbol Acetate