Chlorinated annonaceous acetogenins and their bioactivities.
4(S)-Chloro-4-deoxygigantetrocin A and 4(S), 18-dichloro-4,18-dideoxyasimilobin were obtained by treating gigantetrocin A with triphenylphosphine and CCl4. The structures were determined by spectroscopic methods. The chlorinated compounds show decreased bioactivities in the brine shrimp lethality test and against human tumor cell lines.
Ye
Q
Q
Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Pardue University, West Lafayette, Indiana 47907, USA.
Shi
G
G
He
K
K
McLaughlin
J L
JL
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005233:Fatty Alcohols / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D014407:Tumor Cells, Cultured
C102492:4,18-dichloro-4,18-dideoxyasimilobin; C102491:4-chloro-4-deoxygigantetrocin A; D000903:Antibiotics, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D005233:Fatty Alcohols; D004317:Doxorubicin; D015107:4-Butyrolactone