Iron deficiency anemia among Alaska Natives may be due to fecal loss rather than inadequate intake.
To define more fully the nature of a persistently high prevalence of iron deficiency anemia observed among Alaska Native children, we examined dietary iron intake, hemoglobin concentrations, and storage iron (serum ferritin) based on multiple cross-sectional surveys of Alaska Natives between 1983 and 1989. Approximately 30 to 50% of the children studied < 12 y of age had depleted iron stores. Anemia and depleted iron stores also were prevalent among adult men and women, about twice as prevalent as in the U.S. population based on the Second National Health and Nutrition Examination Survey (NHANES II). The higher rate of iron deficiency, occurring even when the dietary assessment found Alaska Native iron intake to be higher than the U.S. average with an ample intake of food high in bioavailable iron, suggests blood loss as a possible cause of the unusual pattern of iron deficiency observed. In a pilot study of stool blood loss in two villages, 65% of the samples had a significantly elevated stool heme concentration. Further investigation of iron deficiency due to gastrointestinal blood loss for the Alaska Native is warranted.
Petersen
K M
KM
Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), Anchorage, AK 99501, USA.
Parkinson
A J
AJ
Nobmann
E D
ED
Bulkow
L
L
Yip
R
R
Mokdad
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000413:Alaska / Q000453:epidemiology / Q000208:ethnology; D018798:Anemia, Iron-Deficiency / Q000453:epidemiology* / Q000209:etiology* / Q000378:metabolism; D044466:Asian People; D001682:Biological Availability; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003625:Data Collection; D005243:Feces / Q000737:chemistry*; D005260:Female; D005293:Ferritins / Q000097:blood; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007223:Infant; D007501:Iron / Q000032:analysis* / Q000378:metabolism* / Q000493:pharmacokinetics; D019266:Iron, Dietary / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D014481:United States / Q000453:epidemiology
D006454:Hemoglobins; D019266:Iron, Dietary; D005293:Ferritins; D007501:Iron