Detectable levels of IgM antibodies to hepatitis C virus core protein predict breakthrough in patients with chronic hepatitis C treated with interferon-alpha.
The predictive value of IgM antibodies to hepatitis C virus core antigen (HCcAb) is controversial. We studied 79 patients undergoing interferon-alpha (IFN-alpha) treatment and we found that detectable levels of IgM HCcAb could predict breakthrough on treatment.
Division of Infectious Diseases, Ospedali Riuniti, Bergamo, Italy.
O
O
Fracassetti
R
R
Tambini
V
V
Perani
O
O
Vicari
N
N
Lorenzi
G
G
Delvecchio
D000998:Antiviral Agents / Q000627:therapeutic use*; D006526:Hepatitis C / Q000188:drug therapy* / Q000276:immunology*; D018937:Hepatitis C Antibodies / Q000032:analysis*; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis*; D016898:Interferon-alpha / Q000627:therapeutic use*; D011237:Predictive Value of Tests
D000998:Antiviral Agents; D018937:Hepatitis C Antibodies; D007075:Immunoglobulin M; D016898:Interferon-alpha