Onchocerca volvulus: identification of cDNAs encoding a putative phosphatidyl-ethanolamine-binding protein and a putative partially processed mRNA precursor.
We have identified and sequenced cDNAs of the parasitic nematode Onchocerca volvulus which encode a homologue of phosphatidylethanolamine-binding proteins from mammals. These clones are also closely related to the O. volvulus Ov16 cDNA (Lobos et al., 1990). One identified cDNA clone appears to represent a partially processed precursor. These results suggest that these cDNAs are derived from a complex genomic locus, raising the possibility of polycistronic transcription in this nematode.
Section of Molecular Biology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
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Erttmann
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Gallin
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics* / Q000302:isolation & purification; D017238:Genes, Helminth; D015801:Helminth Proteins; D008969:Molecular Sequence Data; D017181:Onchocerca volvulus / Q000235:genetics*; D016366:Open Reading Frames / Q000235:genetics; D010714:Phosphatidylethanolamines / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*; D016415:Sequence Alignment; D014158:Transcription, Genetic
D002352:Carrier Proteins; D018076:DNA, Complementary; D015801:Helminth Proteins; D010714:Phosphatidylethanolamines; D012333:RNA, Messenger; C102097:Ovd protein, Onchocerca volvulus