Expression of cytochrome P450 isozymes in Syrian hamster after dietary vitamin A supplementation and deficiency.
Expression of hepatic cytochrome P450 isozymes by vitamin A-deficient or -supplemented diet was studied in Syrian hamsters. In male hamsters given a vitamin A-supplemented diet at a level of 250 IU/g-diet for 6 weeks, a marked increase in the activity of testosterone 7 alpha-hydroxylase was observed, accompanied by an elevation in the level of protein immunorelated to CYP2A1. In the hamsters fed a vitamin A-deficient diet for 6 weeks, a decrease was obtained in the total cytochrome P450 content and in the activities of most drug-metabolizing enzymes in livers.
Ushio
F
F
Department of Nutrition, Tokyo Metropolitan Research Laboratory of Public Health, Japan.
Fukuhara
M
M
Bani
M H
MH
Narbonne
J F
JF
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases; D006224:Cricetinae; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004032:Diet; D015151:Immunoblotting; D007527:Isoenzymes / Q000378:metabolism*; D008099:Liver / Q000201:enzymology* / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D009929:Organ Size; D013250:Steroid Hydroxylases / Q000378:metabolism; D014801:Vitamin A / Q000008:administration & dosage*; D014802:Vitamin A Deficiency / Q000201:enzymology*; D015430:Weight Gain
D007527:Isoenzymes; D014801:Vitamin A; D003577:Cytochrome P-450 Enzyme System; D013250:Steroid Hydroxylases; D001189:Aryl Hydrocarbon Hydroxylases; C022724:testosterone 7-alpha-hydroxylase, hamster