Serotonin function in panic disorder: intravenous administration of meta-chlorophenylpiperazine.
A placebo-controlled study of the direct serotonin receptor agonist meta-chlorophenylpiperazine (MCPP), intravenously infused over 90 s in a 0.06 mg/kg dose, was conducted in 10 patients with panic disorder and 9 normal control subjects. Cortisol, MCPP serum levels, and behavioral responses in both groups. Differences between intravenous and oral administration of MCPP are discussed, and the present findings are related to the serotonergic hypothesis of panic disorder.
Department of Psychiatry, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467-2490, USA.
S
S
Wetzler
G M
GM
Asnis
J M
JM
DeLecuona
O
O
Kalus
D000284:Administration, Oral; D000328:Adult; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007275:Injections, Intravenous; D008297:Male; D016584:Panic Disorder / Q000188:drug therapy*; D010879:Piperazines / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use*; D012701:Serotonin / Q000502:physiology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use*
D006854:Hydrocortisone; D010879:Piperazines; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors; C015068:1-(3-chlorophenyl)piperazine