Pediatric Rasmussen encephalitis: social communication, language, PET and pathology before and after hemispherectomy.
This prospective case study examined social communication (i.e., formal thought disorder, cohesion), language, positron emission tomography glucose utilization, and neuropathology in four children with Rasmussen encephalitis who achieved seizure control following right hemispherectomy. Prior to hemispherectomy, all four children had illogical thinking, loose associations, cohesive deficits, and impaired performance on formal language tests. Their postoperative improvement in social communication and language appeared to be related to age of onset, duration of illness, and postsurgical reversibility of hypometabolism in the nonresected prefrontal cortex. These changes were not associated with increase in IQ scores. The variability in the type and extent of pathologic change across subjects reflected the severity and duration of the illness. The study's findings imply that early surgical intervention might have mitigated certain aspects of the social communication and linguistic deficits found in these children.
Caplan
R
R
Department of Psychiatry, University of California, Los Angeles, USA.
Curtiss
S
S
Chugani
H T
HT
Vinters
H V
HV
D000293:Adolescent; D017668:Age of Onset; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D003142:Communication; D018792:Encephalitis, Viral / Q000503:physiopathology* / Q000601:surgery*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007806:Language Disorders / Q000175:diagnosis; D017397:Prefrontal Cortex / Q000378:metabolism; D011446:Prospective Studies; D014055:Tomography, Emission-Computed
D005947:Glucose