Reduced renal clearance of furancarboxylic acid, a major albumin-bound organic acid, in undialyzed uremic patients.
3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid (CMPF) is accumulated in uremic serum as a major albumin-bound organic acid. We determined both serum and urine levels of total CMPF to calculate renal clearance of CMPF in healthy subjects and undialyzed uremic patients. Urinary excretion of CMPF and renal clearance were significantly decreased in the uremic patients. The relative clearance ratios of CMPF to creatinine were as low as 0.43% in healthy subjects and 0.45% in uremic patients, indicating that only the protein-unbound, free form of serum CMPF (about 0.4%) is ultrafiltrated in the glomeruli and then excreted into urine. In conclusion, CMPF is accumulated in uremic serum as a consequence of its reduced renal clearance. Urinary excretion of CMPF may be explained only by glomerular filtration of free CMPF in the blood.
Nagoya University Branch Hospital, Japan.
M
M
Sato
M
M
Koyama
T
T
Miyazaki
T
T
Niwa
D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000378:metabolism; D005663:Furans / Q000097:blood / Q000378:metabolism* / Q000652:urine; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D011422:Propionates / Q000097:blood / Q000378:metabolism* / Q000652:urine; D012016:Reference Values; D012709:Serum Albumin; D018629:Spectrometry, Mass, Secondary Ion; D014511:Uremia / Q000097:blood / Q000378:metabolism* / Q000652:urine
D005663:Furans; D011422:Propionates; D012709:Serum Albumin; C041693:3-carboxy-4-methyl-5-propyl-2-furanpropionic acid; D003404:Creatinine