Ossifying fibroma of the skull in a patient with neurofibromatosis type 1. Case report.
Ossifying fibroma is a rare, benign, primary bone tumor that occurs most commonly in the mandible; a cranial vault location is extremely rare. In this report a case of symptomatic frontoparietotemporal ossifying fibroma with intracranial growth and cerebral displacement in a 12-year-old boy with neurofibromatosis type 1 (NF1) is described. Once excised the lesion did not recur. The skeletal system is frequently affected in NF1, and bone abnormalities are present in 50% to 70% of patients with this condition. The etiology of such lesions in NF1 is still controversial. To the authors' knowledge, ossifying fibromas of calvarial bones have not been described in NF1.
Division of Pediatric Neurology, University of Catania, Italy.
M
M
Ruggieri
V
V
Pavone
A
A
Tiné
A
A
Polizzi
G
G
Magro
P H
PH
Duray
M
M
Merino
V
V
Albanese
D002648:Child; D018214:Fibroma, Ossifying / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008297:Male; D009456:Neurofibromatosis 1 / Q000000981:diagnostic imaging / Q000473:pathology*; D012888:Skull Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed