Long-term consequences of subtle stimuli during the first twenty-four hours of seizure-induced brain injury.
Chronically epileptic (induced by a single systemic injection of lithium and pilocarpine about 30 days before the experiment began) male rats were trained within a radial maze while they were administered either GABA-pentin (Neurontin), or prednisolone or given no treatment. There was no significant improvement in learning or memory between the groups. Numbers of trials per day were positively correlated with the time required to display the overt stereotyped forelimb clonus after the single pilocarpine injection. The numbers of correct trials completed during the first few days of acquisition were significantly greater for the rats that had receive weak (1 microT) complex, pulsed magnetic fields over the right hemisphere during the first 24 hr. after seizure induction than for those who received the same field over the left hemisphere or that had been exposed to reference conditions. Implications of the enhanced sensitivity of limbic neurons to subtle electromagnetic interaction during electrical lability are discussed.
Laurentian University, Sudbury, Ontario, Canada.
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Cook
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Persinger
D000085:Acetates / Q000494:pharmacology; D000588:Amines; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001070:Appetitive Behavior / Q000187:drug effects / Q000502:physiology; D001925:Brain Damage, Chronic / Q000139:chemically induced / Q000503:physiopathology*; D002799:Cholinergic Fibers / Q000187:drug effects / Q000502:physiology; D003509:Cyclohexanecarboxylic Acids; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology; D004574:Electromagnetic Fields; D000077206:Gabapentin; D008032:Limbic System / Q000187:drug effects / Q000503:physiopathology; D008094:Lithium; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology*; D011939:Mental Recall / Q000187:drug effects / Q000502:physiology*; D010862:Pilocarpine; D011239:Prednisolone / Q000494:pharmacology; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D010862:Pilocarpine; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D008094:Lithium; D011239:Prednisolone