Diaphyseal telangiectatic osteosarcoma as a second tumor after bilateral retinoblastomas.
In this report, we describe the clinical, imaging, and pathologic findings in a case of diaphyseal telangiectatic osteosarcoma arising 23 years after successful treatment of bilateral retinoblastomas. To our knowledge, telangiectatic osteosarcoma occurring as a second tumor in this setting, outside the radiation treatment field, has not been previously reported. The association of the RB-1 gene defect with retinoblastomas and other tumors is discussed. Also, the computed tomography and magnetic resonance imaging findings in telangiectatic osteosarcoma are described and discussed.
Department of Radiology, University of British Columbia, Vancouver, Canada.
M J
MJ
Brown
P M
PM
Logan
J X
JX
O'Connell
D L
DL
Janzen
D G
DG
Connell
D000328:Adult; D005134:Eye Neoplasms / Q000601:surgery; D005260:Female; D005266:Femoral Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D012516:Osteosarcoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography; D012175:Retinoblastoma / Q000601:surgery