Design and synthesis of carbohydrate-based inhibitors of protein-carbohydrate interactions.
Our understanding of carbohydrate-protein interactions has significantly advanced over the past two years. In particular, a healthy amount of literature has appeared on selectins and their relevant ligands. A significant number of carbohydrate-metabolizing enzyme crystal structures have been solved which provide useful starting points for computer-assisted drug design. Some of these proteins have been implicated either directly or indirectly in playing roles in human-disease states, for example, in inflammation, in diabetes and its complications, and in microorganism-induced diseases such as influenza and cholera.
von Itzstein
M
M
Department of Medicinal Chemistry, Victorian College of Pharmacy, Monash University, Parkville, Australia. mark.vonitzstein@vcp.monash.edu.au
Colman
P
P
D000818:Animals; D001665:Binding Sites; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism*
D002241:Carbohydrates; D011506:Proteins