Testotoxicosis proved by immunohistochemical analysis and successfully treated with cyproterone acetate.
We present a case of testotoxicosis diagnosed on the basis of immunohistochemical investigation of the testis. The patient was treated with the antiandrogen cyproterone acetate at a dose of 70-130 mg/m2/day. Clinical and biochemical features are consistent with the diagnosis of testotoxicosis. The long-term experience with cyproterone acetate had been generally satisfactory. There are, to our knowledge, no reports on cyproterone acetate treatment of testotoxicosis.
Department of Urology, Yamagata University School of Medicine, Japan.
K
K
Itoh
T
T
Nakada
Y
Y
Kubota
H
H
Suzuki
M
M
Ishigooka
T
T
Izumi
D000367:Age Factors; D000726:Androgen Antagonists / Q000008:administration & dosage*; D002675:Child, Preschool; D017373:Cyproterone Acetate / Q000008:administration & dosage*; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D007150:Immunohistochemistry; D007985:Leydig Cells / Q000473:pathology; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D011629:Puberty, Precocious / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D013737:Testis / Q000737:chemistry* / Q000473:pathology; D013739:Testosterone / Q000032:analysis* / Q000097:blood
D000726:Androgen Antagonists; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D017373:Cyproterone Acetate; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone