Intraoperative mitomycin C in the treatment of cicatricial obliterations of conjunctival fornices.
OBJECTIVE
To investigate whether the intraoperative use of topical mitomycin C improved the postoperative outcome in cases of cicatricial obliteration of conjunctival fornices.


METHODS
Ten eyes of five patients were subjected to surgical lysis of the synechiae followed by intraoperative application of 0.4 mg mitomycin C per milliliter of saline for 3 to 5 minutes.


RESULTS
After a follow-up period of 12 to 19 months, no recurrence of synechiae was observed, the conjunctival fornices remained open, and conjunctival overgrowths on the cornea did not recur. No adverse effect was observed.


CONCLUSIONS
Intraoperative application of mitomycin C proved useful in the surgical treatment of cicatricial shrinkage of conjunctival fornices.
Department of Physioparhological Optics, University of Padua, School of Medicine, Italy.
A G
AG
Secchi
M S
MS
Tognon
D000287:Administration, Topical; D003228:Conjunctiva / Q000187:drug effects / Q000601:surgery; D003229:Conjunctival Diseases / Q000628:therapy*; D005500:Follow-Up Studies; D006801:Humans; D007430:Intraoperative Care; D016685:Mitomycin / Q000627:therapeutic use*; D019384:Nucleic Acid Synthesis Inhibitors / Q000627:therapeutic use*; D009883:Ophthalmic Solutions; D010390:Pemphigoid, Benign Mucous Membrane / Q000628:therapy*
D019384:Nucleic Acid Synthesis Inhibitors; D009883:Ophthalmic Solutions; D016685:Mitomycin