Increased levels of plasma thrombomodulin are associated with vascular and all-cause mortality in patients on long-term anticoagulant treatment.
BACKGROUND
The aim of the study was to test if plasma levels of thrombomodulin could predict mortality in 209 patients on long-term anticoagulant treatment followed up for 3.8 years.


RESULTS
The thrombomodulin level was 60.9 +/- 29.8 micrograms.l-1 for all 45 patients who died and 60.5 +/- 30.5 micrograms.l-1 for the 38 vascular deaths, compared to 52.3 +/- 20.7 micrograms.l-1 for the 164 survivors. We found that, in Cox regression analyses, all-cause (P = 0.025) and vascular mortality (P = 0.042) was significantly and independently associated with increased levels of thrombomodulin.


CONCLUSIONS
The level of plasma thrombomodulin can predict all-cause and vascular mortality in patients on long-term anticoagulant treatment.
Department of Medicine, Skellefteå Hospital, Sweden.
J H
JH
Jansson
K
K
Boman
M
M
Brännström
T K
TK
Nilsson
D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000097:blood / Q000188:drug therapy / Q000401:mortality*; D002423:Cause of Death; D005500:Follow-Up Studies; D006801:Humans; D008134:Long-Term Care; D011517:Prothrombin Time; D012044:Regression Analysis; D012306:Risk; D016019:Survival Analysis; D013548:Sweden / Q000453:epidemiology; D013923:Thromboembolism / Q000097:blood / Q000188:drug therapy / Q000401:mortality*; D018180:Thrombomodulin / Q000097:blood*
D000925:Anticoagulants; D018180:Thrombomodulin