Immunohistochemical study of 100 pancreatic tumors in 28 patients with multiple endocrine neoplasia, type I.
One hundred pancreatic tumors ranging in size from 0.3 to 7 cm were studied in 28 patients (17 male and 11 female patients; mean age 35 years) with multiple endocrine neoplasia, type I. An immunohistochemical study was performed on deparaffinized sections using the following antibodies: neuron-specific enolase, chromogranin A or synaptophysin, insulin, glucagon, somatostatin, pancreatic polypeptide (PP), vasoactive intestinal peptide (VIP), gastrin, adrenocorticotropic hormone, alpha-subunit of human chorionic gonadotropin, gonadotropin-releasing factor, serotonin, and calcitonin. Among the 100 tumors (all multiple), seven were unclassified, 10 were plurihormonal, and 83 produced a predominant hormonal secretion (with 50-90% of the same cell type), including 37 "A-cell tumors" (glucagon), 27 "B-cell tumors" (insulin), 11 PP-cell tumors, one G-cell tumor (gastrin) and one vasoactive intestinal peptide (VIP)-cell tumor. These multiple tumors had a different predominant hormonal secretion in the same patient in 23 of the 28 cases. There was a preferential association of A-cell tumor and B-cell tumor. Hyperplasia of the islets of Langerhans was not detected in adjacent pancreas. Nesidioblastosis was observed in 30% of cases.
Le Bodic
M F
MF
Department of Pathology, University Hospitals of Nantes, Lille, France.
Heymann
M F
MF
Lecomte
M
M
Berger
N
N
Berger
F
F
Louvel
A
A
De Micco
C
C
Patey
M
M
De Mascarel
A
A
Burtin
F
F
Saint-Andre
J P
JP
D000293:Adolescent; D000328:Adult; D000912:Antibodies, Neoplasm / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D005935:Glucagonoma / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D006801:Humans; D007003:Hypoglycemia / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008875:Middle Aged; D018761:Multiple Endocrine Neoplasia Type 1 / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D013577:Syndrome; D015043:Zollinger-Ellison Syndrome / Q000378:metabolism / Q000473:pathology / Q000601:surgery
D000912:Antibodies, Neoplasm