GABA metabolism controls inhibition efficacy in the mammalian CNS.
The effects of changes in gamma-aminobutyric acid (GABA) metabolism or inhibitory processes was studied in the perforant path-dentate gyrus synapses in rat cortico-hippocampal slices, and in the monosynaptic-reflex circuit in isolated newborn, rat spinal cord. GABA metabolism was modulated by pharmacological block of either the anabolic enzyme glutamate decarboxylase (GAD) or the catabolic enzyme GABA transaminase (GABA-T). The results support the notion that GABA concentration determines the efficacy of inhibition in these regions of the central nervous system (CNS).
Department of Physiology, Faculty of Health Sciences, Ben-Gurion University, Negev, Beer-Sheva, Israel.
H
H
Golan
A E
AE
Talpalar
D
D
Schleifstein-Attias
Y
Y
Grossman
D015097:3-Mercaptopropionic Acid / Q000494:pharmacology; D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors; D000818:Animals; D002490:Central Nervous System / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005071:Evoked Potentials / Q000502:physiology; D005968:Glutamate Decarboxylase / Q000037:antagonists & inhibitors; D006624:Hippocampus / Q000502:physiology; D066298:In Vitro Techniques; D009433:Neural Inhibition / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D004791:Enzyme Inhibitors; D005680:gamma-Aminobutyric Acid; D015097:3-Mercaptopropionic Acid; D000612:4-Aminobutyrate Transaminase; D005968:Glutamate Decarboxylase