Liver transplantation in Italy: preliminary 10-year report. The Monotematica Aisf-Olt Study Group.
Experience in liver transplantation (OLT) in Italy over a ten-year period is reported. Data were obtained using a multiple-items form collected from Italian liver transplant centres (reference centres) and other Italian institutions actively involved both in the processes of evaluation of the candidates and the follow-up of liver transplant recipients (afference centres). During this period, a total of 1046 liver transplants were performed on 954 patients, with a cumulative proportional survival of 71%. The most common indication for liver transplantation was post-hepatitic cirrhosis due to either hepatitis B virus (+/-hepatitis Delta virus) or hepatitis C virus infection. Good survival rates were observed, particularly in controversial indications, such as alcoholic cirrhosis, post-hepatitic hepatitis B virus-related cirrhosis and hepatocellular carcinoma, most likely due to proper and careful selection of the patients. Cirrhosis, secondary to an autoimmunity-based liver disease, showed the highest rate of rejection episodes. Infections, in our study population, were the most common cause of death after transplantation.
Fagiuoli
S
S
Cattedra di Malattie dell'Apparato Digerente, Università di Padova, Italy.
Leandro
G
G
Bellati
G
G
Gasbarrini
A
A
Rapaccini
G L
GL
Pompili
M
M
Rendina
M
M
De Notariis
S
S
Francavilla
A
A
Gasbarrini
G
G
Ideo
G
G
Naccarato
R
R
D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007558:Italy / Q000453:epidemiology; D008107:Liver Diseases / Q000601:surgery*; D016031:Liver Transplantation / Q000401:mortality; D008297:Male; D011183:Postoperative Complications; D012189:Retrospective Studies; D015996:Survival Rate
D007166:Immunosuppressive Agents