Field trials of a formulation containing moxidectin and 6 in 1 vaccines for sheep.
OBJECTIVE
To assess the efficacy and safety of a formulation containing moxidectin and 6 in 1 vaccine in sheep under field conditions.


METHODS
Efficacy and safety study.


METHODS
Two hundred and five crossbred Merino lambs and two hundred and eight Merino ewes were used in the studies.


METHODS
A formulation was made for the simultaneous treatment of sheep with moxidectin and immunisation against clostridial diseases and caseous lymphadenitis. The efficacy against nematodes, vaccine response and safety were assessed.


RESULTS
Effective control of nematodes and responses to antigens were achieved following subcutaneous administration. The formulation was safe to administer; occasional minor tissue reactions were evident, but no other adverse effects of treatment were observed in either pregnant ewes or lambs, using either the recommended dose, or an overdose of the formulation.


CONCLUSIONS
Administration of a formulation containing moxidectin, five clostridial antigens and caseous lymphadenitis antigen proved safe and efficacious under field conditions.
Cyanamid Websters Pry Ltd, New South Wales.
C L
CL
Schwartzkoff
R M
RM
Cobb
D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000009:adverse effects / Q000592:standards*; D000900:Anti-Bacterial Agents; D000906:Antibodies / Q000032:analysis / Q000276:immunology; D000941:Antigens / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D003013:Clostridium / Q000276:immunology; D003015:Clostridium Infections / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary; D004305:Dose-Response Relationship, Drug; D005260:Female; D008199:Lymphadenitis / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary; D018942:Macrolides / Q000008:administration & dosage / Q000009:adverse effects / Q000592:standards; D009349:Nematode Infections / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D009517:New South Wales / Q000453:epidemiology; D011247:Pregnancy; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control*; D014611:Vaccination / Q000662:veterinary; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000009:adverse effects / Q000592:standards*
D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D000906:Antibodies; D000941:Antigens; D018942:Macrolides; D015164:Vaccines, Inactivated; C027837:moxidectin