Epidemiologic determinants of seroreactivity to human papillomavirus (HPV) type 16 virus-like particles in cervical HPV-16 DNA-positive and-negative women.
The epidemiologic determinants of seroreactivity to human papillomavirus (HPV) type 16 L1/L2 virus-like particles (VLPs) were assessed separately in HPV-16 DNA-positive and -negative women participating in a nested case-control study of incident cervical neoplasia. Seventy-four women with cervical HPV-16 DNA and 656 cytologically normal HPV-16 DNA-negative subjects were interviewed and tested at two time points for viral DNA and once (at the later time) for VLP seroreactivity. Among subjects who were currently HPV-16 DNA-negative, seroreactivity odds ratios increased from 2.9 for 2-5 male sex partners (vs. 0 or 1) to 5.4 for 6-9 partners and 14.0 for > or = 10. Thus, prior cervical infection may be a major determinant of seroreactivity in HPV-16 DNA-negative women. This trend was not observed in HPV-16 DNA-positive subjects. Seroreactivity was independently associated with oral contraceptive use, particularly in HPV-16 DNA-negative subjects with use for > or = 10 years. Consequently, a possible role for virus-steroid hormone interactions in seroconversion is suggested.
Wideroff
L
L
Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, MD 20892-7374, USA.
Schiffman
M H
MH
Hoover
R
R
Tarone
R E
RE
Nonnenmacher
B
B
Hubbert
N
N
Kirnbauer
R
R
Greer
C E
CE
Lorincz
A T
AT
Manos
M M
MM
Glass
A G
AG
Scott
D R
DR
Sherman
M E
ME
Buckland
J
J
Lowy
D
D
Schiller
J
J
D000914:Antibodies, Viral / Q000097:blood*; D016022:Case-Control Studies; D002584:Cervix Uteri / Q000821:virology*; D003276:Contraceptives, Oral / Q000009:adverse effects; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D027383:Papillomaviridae / Q000235:genetics / Q000276:immunology*; D012725:Sexual Behavior; D002583:Uterine Cervical Neoplasms / Q000821:virology*; D014771:Virion / Q000276:immunology*
D000914:Antibodies, Viral; D003276:Contraceptives, Oral; D004279:DNA, Viral