Localization of the human IL-2-inducible T-cell kinase gene (ITK) to chromosome band 5q34 and the mouse gene (Itk) to chromosome 15 by fluorescence in situ hybridization.
ITK, predominantly expressed on T cells and myeloid cells, is a member of the Tec nonreceptor tyrosine kinase family. Both human ITK and mouse Itk genomic clones were isolated to assign the chromosome location. The human ITK gene was mapped to chromosome band 5q34 and the mouse gene to chromosome 15 by fluorescence in situ hybridization.
Department of Surgical Pathology, Showa University Fujigoka Hospital, Yokohama, Japan.
G
G
Tate
M
M
Okuyama
M
M
Okamoto
G
G
Futaki
S
S
Kimura
Y
Y
Endo
T
T
Mitsuya
M
M
Katagiri
D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D015342:DNA Probes; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007376:Interleukin-2 / Q000502:physiology; D051379:Mice; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D013601:T-Lymphocytes / Q000201:enzymology
D015342:DNA Probes; D007376:Interleukin-2; D011505:Protein-Tyrosine Kinases; C080813:emt protein-tyrosine kinase