HLA-DR2 antigen linkage in patients with apical hypertrophic cardiomyopathy in Japan.
Apical hypertrophic cardiomyopathy, a very common disorder in Japan, is characterized by giant negative T waves on the electrocardiogram and abnormal apical hypertrophy on the ventriculogram. This histocompatibility complexes (HLA-A, -B, -C, -DR) of 20 unrelated patients with apical hypertrophic cardiomyopathy (18 male, 2 female) were examined. There was no significant difference in the frequency of HLA-A, -B, -C antigens between patients and controls (n = 100). However, HLA-DR 2 was more frequent in patients with apical hypertrophic cardiomyopathy (65.0%) than controls (33.0%) (p < 0.01). We conclude that apical hypertrophic cardiomyopathy might be associated with genes in the HLA-DR region and that genetic factors linked to HLA play a role in the pathogenesis of this disease.
Second Department of Internal Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
C
C
Kishimoto
H
H
Takada
Y
Y
Hiraoka
M
M
Suzaki
E
E
Maruya
N
N
Tomioka
D002312:Cardiomyopathy, Hypertrophic / Q000235:genetics* / Q000276:immunology; D016009:Chi-Square Distribution; D004562:Electrocardiography; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D015802:HLA-DR2 Antigen / Q000032:analysis*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male
D006680:HLA Antigens; D015802:HLA-DR2 Antigen