Cardiac output in asymptomatic primary hyperparathyroidism: a stigma of early cardiovascular dysfunction?
The resting cardiac output pre- and postoperatively in 10 patients with asymptomatic primary hyperparathyroidism has been studied. All patients had normal renal function and arterial blood pressure without a previous history of cardiovascular disease. Ten normotensive patients with a non-toxic goitre awaiting thyroidectomy were studied as controls. The mean cardiac output of the hyperparathyroid patients was 7.2 l/minute (range 5.3-8.9) and of the control group 5.8 l/minute (range 5.2-6.3). Following a successful parathyroidectomy with return of the serum calcium to normal, the mean cardiac output was 6.3 l/minute (range 4.9-7.8) (p < 0.04). In 8 of the 10 patients there was a fall in the cardiac output following surgery; in 2 there was an increase. These results suggest that hyperparathyroid patients often have an elevated cardiac output which may fall following a successful parathyroidectomy.
Royal London Hospital Medical College, University of London, Academic Surgical Unit, Whitechapel, UK.
S N
SN
Georgiannos
B J
BJ
Jenkins
A W
AW
Goode
D000236:Adenoma / Q000150:complications / Q000601:surgery; D000328:Adult; D000368:Aged; D002302:Cardiac Output; D015150:Echocardiography, Doppler; D006801:Humans; D006961:Hyperparathyroidism / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery; D008875:Middle Aged; D010282:Parathyroid Neoplasms / Q000150:complications / Q000601:surgery; D016105:Parathyroidectomy