ADCON-L: a review of its development, mechanism of action, and preclinical data.
ADCON-L Anti-Adhesion Barrier Gel is a resorbable gel that is placed into the site of a laminectomy before surgical closure and acts as a barrier to scar and surgical adhesions. The scientific rationale for ADCON products is based on certain properties of glial cells and the nature and role of the basal lamina. ADCON-L was evaluated in laminectomy models using rats and rabbits and a discectomy model in dogs. In all studies, ADCON-L was an effective barrier to peridural scar and surgical adhesions.
Gliatech Inc., Cleveland, Ohio 44122, USA.
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Frederickson
D000818:Animals; D002921:Cicatrix / Q000517:prevention & control; D017586:Diskectomy; D004345:Drug Industry; D004388:Dura Mater / Q000187:drug effects; D005782:Gels / Q000494:pharmacology*; D007796:Laminectomy; D009930:Organic Chemicals; D011183:Postoperative Complications / Q000517:prevention & control; D000267:Tissue Adhesions / Q000517:prevention & control
C104199:ADCON-L; D005782:Gels; D009930:Organic Chemicals