Role of nonspecific cross-reacting antigen, a CD66 cluster antigen, in activation of human granulocytes.
Nonspecific cross-reacting antigen (NCA) is the name of a family of highly glycosylated bacterial-binding receptors found on human granulocytes and other tissues. These glycoproteins are members of the immunoglobulin supergene family and are related structurally to carcinoembryonic antigen. In this study, we demonstrate that ligation of granulocyte NCA results in the activation of the cells, as measured by degranulation and the flux of intracellular calcium. These studies further the proposition that NCA has a function in the immune response of granulocytes against bacterial infections.
Division of Immunology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA.
M L
ML
Klein
S A
SA
McGhee
J
J
Baranian
L
L
Stevens
S A
SA
Hefta
D000911:Antibodies, Monoclonal / Q000276:immunology; D000951:Antigens, Neoplasm; D002118:Calcium / Q000378:metabolism; D015815:Cell Adhesion Molecules; D015550:Cell Degranulation; D019204:GTP-Binding Proteins / Q000502:physiology; D006801:Humans; D007781:Lactoferrin / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000276:immunology / Q000502:physiology*; D018375:Neutrophil Activation; D009504:Neutrophils / Q000502:physiology*; D011494:Protein Kinases / Q000378:metabolism; D015398:Signal Transduction; D019311:Staurosporine / Q000494:pharmacology; D010566:Virulence Factors, Bordetella / Q000494:pharmacology
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D015815:Cell Adhesion Molecules; D008562:Membrane Glycoproteins; D010566:Virulence Factors, Bordetella; D011494:Protein Kinases; D007781:Lactoferrin; D019204:GTP-Binding Proteins; D019311:Staurosporine; D002118:Calcium