Tumor suppressor genes as negative growth regulators in development and differentiation.
Tumor suppressor genes have received much attention for their roles in the development of human malignancies. However, their gene products (proteins) function as negative growth regulators and are highly expressed in many tissues during embryonic development, suggesting that they might function as critical proteins in differentiation and development. The evidence implicating tumor suppressor proteins in cellular differentiation and embryonic development will be presented with special attention to the neurofibromatosis 1, neurofibromatosis 2, and tuberous sclerosis 2 gene products.
Department of Neurology, Washington University School of Medicine, St. Louis, USA.
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Gutmann
D018797:Cell Cycle Proteins / Q000235:genetics; D002454:Cell Differentiation; D002455:Cell Division; D005314:Embryonic and Fetal Development / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D016514:Genes, Neurofibromatosis 1; D016515:Genes, Neurofibromatosis 2; D016147:Genes, Tumor Suppressor; D008565:Membrane Proteins / Q000502:physiology; D008954:Models, Biological; D025542:Neurofibromin 1; D025581:Neurofibromin 2; D011506:Proteins / Q000502:physiology; D012097:Repressor Proteins / Q000502:physiology; D014402:Tuberous Sclerosis / Q000235:genetics; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins
D018797:Cell Cycle Proteins; D008565:Membrane Proteins; D025542:Neurofibromin 1; D025581:Neurofibromin 2; D011506:Proteins; D012097:Repressor Proteins; C000624653:TSC2 protein, human; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins