Nomograms to help inform women considering Down's syndrome screening.
OBJECTIVE
To derive graphical information for use in counselling women considering whether or not to have maternal serum screening for Down's syndrome.


METHODS
Statistical modelling of the frequency distribution of estimated Down's syndrome risk for four marker combinations.


RESULTS
Nomograms are provided showing for each maternal age: (a) the detection and false-positive rates, and (b) the proportion of pregnancies with different estimated risks.


CONCLUSIONS
When screening is offered, clinicians need to have information readily available on test accuracy and the likely result, which is specific to the individual.
Cuckle
H S
HS
Centre for Reproduction, Growth and Development, Research School of Medicine, Leeds, UK. howardc@epid.leeds.ac.uk
Sehmi
I K
IK
Holding
S
S
D006063:Chorionic Gonadotropin / Q000032:analysis; D004314:Down Syndrome / Q000175:diagnosis / Q000196:embryology / Q000453:epidemiology / Q000517:prevention & control*; D004964:Estriol / Q000032:analysis; D005189:False Positive Reactions; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis / Q000196:embryology / Q000453:epidemiology / Q000517:prevention & control*; D005817:Genetic Counseling / Q000379:methods*; D006801:Humans; D008403:Mass Screening / Q000523:psychology; D008423:Maternal Age; D011296:Prenatal Diagnosis; D012307:Risk Factors; D000509:alpha-Fetoproteins / Q000032:analysis
D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins; D004964:Estriol