Role of tissue factor and factor VIIa in the coagulant and inflammatory response to LD100 Escherichia coli in the baboon.
Anti-tissue factor antibody and active site-inhibited factor VIIa inhibit both the disseminated intravascular coagulant response to LD100 Escherichia coli and its lethal inflammatory effects. In contrast, active site inhibited factor Xa while completely inhibiting disseminated intravascular coagulant does not protect baboons from LD100 E. coli. This review examines the role of tissue factor and factor VIIa in initiating the disseminated intravascular coagulant response and in amplifying the inflammatory response.
Oklahoma Medical Research Foundation, Okalahoma City 73104, USA.
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Taylor
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D004211:Disseminated Intravascular Coagulation / Q000097:blood*; D004926:Escherichia coli / Q000502:physiology; D015942:Factor VIIa / Q000502:physiology*; D065427:Factor Xa Inhibitors; D008969:Molecular Sequence Data; D010215:Papio; D013925:Thromboplastin / Q000276:immunology / Q000502:physiology*
D065427:Factor Xa Inhibitors; D013925:Thromboplastin; D015942:Factor VIIa