Assignment of the gene encoding type 1 gamma protein phosphatase catalytic subunit (PPP1CC) on human, rat, and mouse chromosomes.
Using fluorescent in situ hybridization (FISH) method, a gene encoding the catalytic subunit of protein phosphatase type 1 gamma (PPP1CC) was mapped to human 12q24.1-q24.2, rat 7 q22, and mouse 10C. These results indicate that the PPP1CC is a member of conserved synteny group between rat chromosome 7, mouse chromosome 10 and human chromosome 12. These data and mapping data about other members of PP1 family show that in spite of the high identity of PP1 isoforms, each isoform is encoded by different genes which located on different chromosomes in human, rat, and mouse.
Section of Biochemistry, Hokkaido University, Sapporo, Japan.
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Saadat
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Nomoto
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Mizuno
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Kikuchi
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Yoshida
D000818:Animals; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D006801:Humans; D006822:Hybrid Cells; D046911:Macromolecular Substances; D051379:Mice; D008809:Mice, Inbred C3H; D005810:Multigene Family; D010749:Phosphoprotein Phosphatases / Q000235:genetics*; D051381:Rats; D011919:Rats, Inbred Strains
D046911:Macromolecular Substances; D010749:Phosphoprotein Phosphatases