Treatment of bilateral cytomegalovirus retinitis with sustained-release ganciclovir implants in a child.
OBJECTIVE
To report treatment of bilateral cytomegalovirus (CMV) retinitis in an 11-year-old girl with acquired immunodeficiency syndrome (AIDS).


METHODS
Case report describing the use of intravitreal ganciclovir sustained-release devices to treat CMV retinitis, involving zones 1 through 3, which progressed despite single and combination intravenous therapy with ganciclovir and foscarnet.


RESULTS
Stabilization with no active CMV retinitis was achieved after bilateral implantation of intravitreal sustained-release ganciclovir devices. There was no reactivation of the retinitis during the 5 months of follow-up.


CONCLUSIONS
Sustained-release ganciclovir implants can be used to achieve local control of CMV retinitis in the pediatric patient.
Department of Ophthalmology, New York Hospital-Cornell Medical Center, New York, USA.
D S
DS
Malley
R
R
Barone
M H
MH
Heinemann
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000473:pathology; D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D017726:Cytomegalovirus Retinitis / Q000188:drug therapy* / Q000473:pathology; D004343:Drug Implants; D005260:Female; D005500:Follow-Up Studies; D005654:Fundus Oculi; D015774:Ganciclovir / Q000627:therapeutic use*; D006801:Humans; D014792:Visual Acuity; D014822:Vitreous Body
D000998:Antiviral Agents; D004343:Drug Implants; D015774:Ganciclovir