Interactive effects of depression symptoms, nicotine dependence, and weight change on late smoking relapse.
Signal detection methods were used to develop an algorithm useful in distinguishing those at risk for late relapse from those likely to maintain abstinence. Four subgroups with 24-month survival (nonrelapse) rates ranging from 79% to 33% were identified. Among participants whose depression symptoms decreased from baseline to the end of treatment, lower levels of nicotine dependence were associated with less relapse at the 24-month follow-up (odds ratio = 2.77; 95% confidence interval: 1.36-5.62). Among participants whose depression symptoms increased from baseline to the end of treatment, greater weight gain was associated with less relapse at follow-up (odds ratio = 2.90; 95% confidence interval: 1.41-5.96). This study suggested that it may become possible to use both baseline and treatment information to "titrate" interventions.
Center for Research in Disease Prevention, Stanford University School of Medicine, California 94304, USA. Killen@scrdp.stanford.edu
J D
JD
Killen
S P
SP
Fortmann
H C
HC
Kraemer
A N
AN
Varady
L
L
Davis
B
B
Newman
D000465:Algorithms; D001521:Behavior Therapy; D001835:Body Weight / Q000187:drug effects*; D002638:Chewing Gum; D003863:Depression / Q000523:psychology*; D005500:Follow-Up Studies; D006801:Humans; D009538:Nicotine / Q000008:administration & dosage / Q000009:adverse effects; D012008:Recurrence; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000523:psychology*; D016540:Smoking Cessation / Q000523:psychology*; D013375:Substance Withdrawal Syndrome / Q000523:psychology; D019966:Substance-Related Disorders / Q000523:psychology*; D016019:Survival Analysis; D016896:Treatment Outcome
D002638:Chewing Gum; D009538:Nicotine