Allergy development and macromolecular absorption in infants with different feeding regimens during the first three days of life. A three-year prospective follow-up.
A group of 129 infants were randomly assigned at birth to one of three feeding regimens: human milk (HM), cow's milk formula (CMF) or a casein hydrolysate formula (CHF) during the first 3 days of life. Blood samples were taken on at 4 days and at 2, 4, 8, 12 and 24 months of age. Macromolecular absorption was analysed by measuring the serum concentration of human alpha-lactalbumin (S-alpha-LA) with a competitive radioimmunoassay (RIA). Total serum IgE was measured by RIA. A family history of allergy correlated to the proportion of infants with allergic symptoms both at 24 and 36 months of age (p = 0.03 and p = 0.04 respectively). In none of the three groups did correlation exist between the duration of breastfeeding and serum alpha-LA, serum IgE, family history of allergy, frequency of allergic symptoms and proportion of infants with infections.
Department of Paediatrics, University of Lund University Hospital, Malmö, Sweden.
P
P
Juvonen
M
M
Månsson
C
C
Andersson
I
I
Jakobsson
D000818:Animals; D002364:Caseins; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology; D007073:Immunoglobulin E / Q000097:blood; D007225:Infant Food; D007231:Infant, Newborn; D007768:Lactalbumin / Q000097:blood; D008297:Male; D008892:Milk; D008895:Milk, Human; D011446:Prospective Studies; D011492:Protein Hydrolysates; D011863:Radioimmunoassay; D012307:Risk Factors
D002364:Caseins; D011492:Protein Hydrolysates; C026375:trypticase-soy broth; D007073:Immunoglobulin E; D007768:Lactalbumin