Pregnancy results after ovum donation following one to seven embryo transfers.
OBJECTIVE
To determine whether failure to achieve pregnancy after repeated ET after ovum donation was due to an endometrial defect or to the embryo quality.


METHODS
Retrospective data analysis.


METHODS
A private infertility center.


METHODS
Four hundred sixty-seven donors (513 cycles) undergoing IVF donating oocytes to 266 recipients (423 cycles).


METHODS
Hormonal endometrial preparation with increasing dosages of valerate E2 (2,4, and 6 mg) and 100 mg of P.


METHODS
Pregnancy rates (PRs) and abortion rates in patients undergoing one to seven ETs after ovum donation.


RESULTS
Pregnancy rates in recipients that had one or two ETs were significantly higher (34.8%) compared with those of recipients having three or more ETs (15.1%). Abortion rates were significantly higher (54.5%) in recipients repeating more than three ETs than in the recipients having one or two ETs (29.1%).


CONCLUSIONS
Recipients that had failed to establish a pregnancy after two ETs had a lower PR in successive attempts, possibly because of a defect of their endometrial lining.
Mantzavinos
T
T
Euromedica Institute of High Technology, Athens, Greece.
Dimitriadou
F
F
Kanakas
N
N
Rizos
D
D
Arvaniti
K
K
Voutsina
K
K
D000022:Abortion, Spontaneous; D000328:Adult; D004624:Embryo Transfer; D004717:Endometrium / Q000473:pathology; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D018587:Oocyte Donation; D011247:Pregnancy; D012189:Retrospective Studies