Autoimmune hemolytic anemia with warm antibodies complicated with an intercurrent attack of hemolysis with cold agglutinins in a case of Waldenström disease.
The paper presents a case of autoimmune hemolytic anemia (AIHA) with warm IgG antibodies associated with Waldenström's disease in which in the stage of compensated hemolysis after treatment, there appeared a severe hemolytic attack induced by transitory cold agglutinins with high thermal amplitude. The case described is a novelty by the intrication of two autoantibody populations which causes autoimmune hemolysis. The difference from other similar associations is discussed.
Fundeni Clinical Hospital, Clinic of Hematology, Bucharest, Romania.
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Gologan
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D000328:Adult; D000373:Agglutinins / Q000097:blood*; D000744:Anemia, Hemolytic, Autoimmune / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D001323:Autoantibodies / Q000097:blood*; D003080:Cold Temperature; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D006358:Hot Temperature; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008258:Waldenstrom Macroglobulinemia / Q000150:complications / Q000175:diagnosis* / Q000628:therapy
D000373:Agglutinins; D001323:Autoantibodies; D007074:Immunoglobulin G