Molecular pharmacology of voltage-dependent calcium channels.
Voltage-dependent Ca2+ channels serve as the only link to transduce membrane depolarization into cellular Ca(2+)-dependent reactions. A wide variety of chemical substances that have the ability to modulate Ca2+ channels have been demonstrated both for their clinic utility and for importance in elucidating the molecular basis of various biological responses. Recently, introduction of molecular biology to pharmacology has brought a great deal of information about the molecular basis of drug action in Ca2+ channels. In this review, we attempt to overview recent progress in understanding the interactions between Ca2+ channels and their blockers, namely Ca2+ antagonists, from a molecular and structural point of view.
Institute of Molecular Pharmacology and Biophysics, University of Cincinnati College of Medicine, Ohio 45267-0828, U.S.A.
Y
Y
Mori
G
G
Mikala
G
G
Varadi
T
T
Kobayashi
S
S
Koch
M
M
Wakamori
A
A
Schwartz
D060848:Agatoxins; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002121:Calcium Channel Blockers / Q000378:metabolism / Q000494:pharmacology*; D015220:Calcium Channels / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D008978:Mollusk Venoms / Q000494:pharmacology; D013111:Spider Venoms / Q000494:pharmacology
D060848:Agatoxins; D002121:Calcium Channel Blockers; D015220:Calcium Channels; D008978:Mollusk Venoms; D013111:Spider Venoms; C060465:omega-agatoxin I