Analgesic and antiinflammatory effects of some 2-mercaptobenzoxazole derivatives.
Analgesic and antiinflammatory effects of benzoxazole derivatives have been investigated in mice. In the acetic acid induced writhing test, the analgesic effect of two compounds were found to be stronger than that of diclofenac sodium. In the formaldehyde induced paw swelling edema test, two compounds were found to be more active than diclofenac sodium, another two were as potent as the control drug.
Department of Pharmaceutical Chemistry, Hacettepe University, Ankara, Turkey.
C
C
Safak
R
R
Simsek
K
K
Erol
K
K
Vural
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D004487:Edema / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D005260:Female; D005528:Foot / Q000473:pathology; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D051381:Rats
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001583:Benzoxazoles