Mapping of a gene for Parkinson's disease to chromosome 4q21-q23.
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately 1 percent of the population over age 50. Recent studies have confirmed significant familial aggregation of PD and a large number of large multicase families have been documented. Genetic markers on chromosome 4q21-q23 were found to be linked to the PD phenotype in a large kindred with autosomal dominant PD, with a Zmax = 6.00 for marker D4S2380. This finding will facilitate identification of the gene and research on the pathogenesis of PD.
Polymeropoulos
M H
MH
Laboratory of Genetic Disease Research, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD 20892-1430, USA.
Higgins
J J
JJ
Golbe
L I
LI
Johnson
W G
WG
Ide
S E
SE
Di Iorio
G
G
Sanges
G
G
Stenroos
E S
ES
Pho
L T
LT
Schaffer
A A
AA
Lazzarini
A M
AM
Nussbaum
R L
RL
Duvoisin
R C
RC
D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D010300:Parkinson Disease / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype
D005819:Genetic Markers