Regulation of glutamic acid decarboxylase mRNA expression in rat brain after sertraline treatment.
We now investigated the effect of chronic treatment with sertraline on glutamic acid decarboxylase mRNA expression in different rat brain areas by means of in situ hybridization. We found a reduced glutamic acid decarboxylase mRNA expression in the prefrontal cortex, accumbens nucleus, olfactory tubercle and reticular nucleus of the thalamus. The involvement of presynaptic modulation of gamma-amino-butyric acid transmission in the anxiolytic effect of sertraline is discussed.
Inst. of Otolaryngol. II, Milano University, Italy. cefisnmo@mbox.vol.it
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Giardino
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Zanni
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Bettelli
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Savina
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Calzà
D015057:1-Naphthylamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D005968:Glutamate Decarboxylase / Q000235:genetics*; D017403:In Situ Hybridization; D008297:Male; D012333:RNA, Messenger / Q000235:genetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D020280:Sertraline
D015057:1-Naphthylamine; D005968:Glutamate Decarboxylase; D012333:RNA, Messenger; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline