Synthesis and quantitative structure-activity relationships of antihyperlipaemic 2-substituted thieno[3,2-d]pyrimidin-4(3H)-ones.
The synthesis, antihyperlipaemic evaluation and quantitative structure-activity relationships (QSAR) of two series of thieno[3,2-d]pyrimidin-4-one derivatives are reported. While most of the compounds in these series were found to exhibit antihyperlipaemic activity, the QSAR study of these two series indicated a positive influence of only the electronic nature of the 2-substitutents on the biological activity. The lipophilic and the steric parameters did not appear to be significant.
Shishoo
C J
CJ
L. M. College of Pharmacy, Ahmedabad, India.
Jain
K S
KS
Rathod
I S
IS
Thakkar
B J
BJ
Brahmbhatt
S B
SB
Gandhi
T P
TP
Bangaru
R
R
Goyal
R K
RK
D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002784:Cholesterol / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D008968:Molecular Conformation; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012044:Regression Analysis; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
D000960:Hypolipidemic Agents; D007202:Indicators and Reagents; D011743:Pyrimidines; D002784:Cholesterol