Hepatitis and hepatocellular carcinoma in two prairie dogs (Cynomys ludovicianus).
In two blacktailed prairie dogs (Cynomys ludovicianus), hepatocellular carcinoma with metastasis to the lung, co-existing chronic active hepatitis, and hyperplasia of hepatocytes in the non-neoplastic areas of the liver tissue were observed. The hyperplastic hepatocytes had many eosinophilic inclusion bodies positive for orcein stain in their cytoplasm. Electron microscopy revealed areas of a specific mail-like mesh structure in the location of the cytoplasmic inclusion bodies. Ultrastructure of inclusion bodies differed from that of the hepadna virus usually associated with hepatocellular carcinoma, and hepadna virus-like particles were not observed.
Department of Veterinary Pathology, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
Y
Y
Une
S
S
Tatara
Y
Y
Nomura
R
R
Takahashi
Y
Y
Saito
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D006520:Hepatitis, Animal / Q000175:diagnosis* / Q000473:pathology; D002479:Inclusion Bodies / Q000737:chemistry / Q000648:ultrastructure; D008099:Liver / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D008175:Lung Neoplasms / Q000556:secondary / Q000662:veterinary; D008297:Male; D008854:Microscopy, Electron / Q000662:veterinary; D010078:Oxazines / Q000032:analysis; D012589:Sciuridae
D010078:Oxazines; C002313:PAcein