Simian cytomegalovirus-related stealth virus isolated from the cerebrospinal fluid of a patient with bipolar psychosis and acute encephalopathy.
A cytopathic 'stealth' virus was cultured from the cerebrospinal fluid of a patient with a bipolar psychotic disorder who developed a severe encephalopathy leading to a vegetative state. DNA sequencing of a polymerase chain reaction-amplified product from infected cultures has identified the virus as an African green monkey simian cytomegalovirus (SCMV)-related stealth virus. The virus is similar to the SCMV-related stealth virus isolated from a patient with chronic fatigue syndrome. The findings support the concepts that stealth viruses can account for a spectrum of dysfunctional brain diseases and that some of these viruses may have arisen from live polio viral vaccines.
Center for Complex Infectious Diseases, Rosemead, CA 91770, USA.
W J
WJ
Martin
D000328:Adult; D000818:Animals; D001483:Base Sequence; D001714:Bipolar Disorder / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000209:etiology / Q000821:virology*; D002478:Cells, Cultured / Q000821:virology; D002555:Cerebrospinal Fluid / Q000821:virology; D002522:Chlorocebus aethiops / Q000821:virology*; D003587:Cytomegalovirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000134:cerebrospinal fluid / Q000150:complications / Q000175:diagnosis / Q000635:transmission / Q000821:virology*; D003588:Cytopathogenic Effect, Viral; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D003937:Diagnosis, Differential; D004340:Drug Contamination; D018792:Encephalitis, Viral / Q000134:cerebrospinal fluid / Q000150:complications / Q000175:diagnosis / Q000821:virology*; D004829:Epilepsy, Generalized / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005347:Fibroblasts / Q000821:virology; D006212:Hallucinations / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D008253:Macaca mulatta; D008969:Molecular Sequence Data; D018458:Persistent Vegetative State / Q000209:etiology; D011055:Poliovirus Vaccine, Oral / Q000009:adverse effects; D012559:Schizophrenia / Q000175:diagnosis; D016415:Sequence Alignment; D013045:Species Specificity; D014776:Virus Cultivation
D004279:DNA, Viral; D011055:Poliovirus Vaccine, Oral