Minimal effect of CNTF on the ultrastructure of axotomised motoneurones in the adult rat.
The ultrastructural effects of CNTF or BSA on the retrograde response of adult rat spinal motoneurones were quantified at 7 days. Axotomy with or without CNTF or BSA generally resulted in fragmentation of the rough endoplasmic reticulum (RER). One third of CNTF-treated motoneurones had RER with a more ordered lamella arrangement than controls. Decreased area of the Golgi apparatus was seen after CNTF and BSA treatment. Other features of the retrograde response were unaffected.
Department of Anatomy and Developmental Biology, Royal Free Hospital School of Medicine, London, UK.
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T
Demetriou
R M
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Duberley
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Johnson
D000818:Animals; D001370:Axonal Transport; D001369:Axons / Q000187:drug effects / Q000502:physiology*; D020934:Ciliary Neurotrophic Factor; D005260:Female; D017628:Microglia / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure*; D009046:Motor Neurons / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure*; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D013116:Spinal Cord / Q000166:cytology
D020934:Ciliary Neurotrophic Factor; D009419:Nerve Tissue Proteins; D012710:Serum Albumin, Bovine