Gellan in sustained release formulations: preparation of gel capsules and release studies.
The ability of gellan to form gels in the presence of calcium ions enabled us to prepare capsules by gelation of this polysaccharide around a core containing starch, calcium chloride and a model drug. Release from the dried capsules was studied in vitro by means of the rotating basket technique (USP) in different environmental conditions (distilled water, pH = 2.0, pH = 6.8) and the effects of the presence of increasing amounts of drug in the formulation were also investigated. The behaviour of the gellan capsules was compared with that of beads prepared with the same polysaccharide but containing different additives. Results obtained indicate that gellan is suitable for the formulation of sustained release capsules and that solvent uptake by the dried capsules is most likely the main factor capable of affecting the rate of delivery from the tested preparations.
Dipartimento di Studi di Chimica, Facoltà di Farmacia, Università di Roma (La Sapienza), Italy.
F
F
Alhaique
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E
Santucci
M
M
Carafa
T
T
Coviello
E
E
Murtas
F M
FM
Riccieri
D002122:Calcium Chloride / Q000737:chemistry / Q000378:metabolism; D002214:Capsules; D003470:Culture Media; D003692:Delayed-Action Preparations; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D011135:Polysaccharides, Bacterial / Q000378:metabolism*; D013213:Starch / Q000737:chemistry / Q000378:metabolism
D002214:Capsules; D003470:Culture Media; D003692:Delayed-Action Preparations; D011135:Polysaccharides, Bacterial; C048288:gellan gum; D013213:Starch; D002122:Calcium Chloride