A comparative study of the therapeutic effect of probucol and pravastatin on xanthelasma.
We examined and compared the effects of probucol and pravastatin on the regression of xanthelasma. Thirty-six cases treated by probucol and 18 cases by pravastatin were evaluated for 12 months. Thirteen of the 36 cases treated with probucol showed regression of xanthelasma. However, one of the 18 cases treated with pravastatin showed regression. These data were statistically significantly. The average total cholesterol value in both groups decreased during drug therapy. However, the average of HDL-cholesterol values in the probucol treatment group showed significant decreases, but those in the pravastatin treatment group did not. We discussed the mechanisms of the two drugs on the regression of xanthelasma and the mechanisms of development of xanthelasma.
Department of Dermatology, School of Medicine, Chiba University, Japan.
M
M
Fujita
K
K
Shirai
D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017035:Pravastatin / Q000008:administration & dosage / Q000627:therapeutic use*; D011341:Probucol / Q000008:administration & dosage / Q000627:therapeutic use*; D012871:Skin Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome; D014973:Xanthomatosis / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology
D000924:Anticholesteremic Agents; D017035:Pravastatin; D011341:Probucol