High-density mapping of chromosomal arm 1q in renal collecting duct carcinoma: region of minimal deletion at 1q32.1-32.2.
Collecting duct carcinoma (CDC) of the kidney is a rare malignant neoplasm of distal nephron origin. Previous studies of CDC have shown loss of heterozygosity on chromosomal arm 1q in 57% of the cases studied. To better characterize 1q loss in CDC, we performed high-density mapping of the entire long arm of chromosome 1 in 13 CDC tumor samples. We observed complete deletion of chromosomal arm 1q in 5 samples and partial deletion in 4 additional tumors. Our study further showed that the region of minimal deletion is located at 1q32.1-32.2. Sixty-nine percent (9 of 13) of the tumors showed loss of heterozygosity in this area. These data suggest that a gene or group of genes that contribute to the development of distal nephron tumors may be located within the 1q32.1-32.2 region.
James Buchanan Brady Urological Institute, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA.
G
G
Steiner
P
P
Cairns
T J
TJ
Polascik
F F
FF
Marshall
J I
JI
Epstein
D
D
Sidransky
M
M
Schoenberg
D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D007685:Kidney Tubules, Collecting