Effects in vitro of pachymatismin, a glycoprotein from the marine sponge Pachymatisma johnstonii, on a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6).
Pachymatismin is a new cytostatic factor extracted from the marine sponge Pachymatisma johnstonii Bowerbank 1842 (Demospongiae, Geodiidae), which has an antiproliferative effect in vitro on cells from a human non-small-cell bronchopulmonary carcinoma (NSCLC-N6). The substance, both administered as a continuous and discontinuous treatment, triggers the irreversible arrest of cells in the G0/G1 phase of the cell cycle and morphological changes, thereby causing their destruction. Taken all together, these observations suggest that pachymatismin would induce atypical terminal cellular differentiation.
Zidane
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Laboratoire de Pharmacologie Marine, Faculté de Pharmacie, Nantes, France.
Pondaven
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Roussakis
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D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001685:Biological Factors / Q000494:pharmacology*; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology; D002453:Cell Cycle / Q000187:drug effects / Q000235:genetics; D004354:Drug Screening Assays, Antitumor; D006023:Glycoproteins / Q000494:pharmacology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008175:Lung Neoplasms / Q000473:pathology; D011161:Porifera / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000473:pathology
D000970:Antineoplastic Agents; D001685:Biological Factors; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; C106743:pachymatismin protein, Pachymatisma johnstonii