Expression of 17 alpha-hydroxylase and aromatase in the syndrome of androgen resistance: a case report.
A complete form of testicular feminization with normal gonadotropin and high testosterone levels is described. The testicular histology of tubular atrophy and hyperplastic Leydig cells accords with the high testosterone levels. We evaluated the expression of the enzymes involved in the production of testosterone and estrogens. An increase in P450c17 (17 alpha-hydroxylase/17,20-lyase) messenger RNA expression has been shown in testis with androgen resistance compared with in normal testis. More P450 aromatase was expressed in normal testis than in testis with androgen resistance.
Department of Obstetrics and Gynecology, University of Milan, San Raffaele Scientific Institute, Italy.
N
N
Doldi
M
M
Bassan
L
L
Belvisi
A
A
Messa
A
A
Ferrari
D000328:Adult; D013734:Androgen-Insensitivity Syndrome / Q000201:enzymology* / Q000235:genetics; D000728:Androgens / Q000378:metabolism; D001141:Aromatase / Q000096:biosynthesis* / Q000235:genetics; D004351:Drug Resistance / Q000235:genetics; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics*; D006066:Gonads / Q000737:chemistry / Q000201:enzymology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D013254:Steroid 17-alpha-Hydroxylase / Q000096:biosynthesis* / Q000235:genetics; D013577:Syndrome
D000728:Androgens; D012333:RNA, Messenger; D001141:Aromatase; D013254:Steroid 17-alpha-Hydroxylase