Effects of vaginally delivered estrogens.
Atrophic condition in the vagina and lower parts of the urethral tract are common in elderly women. From population based surveys it has been estimated that 40% or more of women over 60 complain of insufficient control of micturation. In addition, lower urinary tract infections are common in this age group and recurrent cystitis is a scourge for many women (1, 2). Vaginal problems such as vaginal dryness, dyspareunia as well as infectious and non infectious disorders in the vagina may be even more common in elderly women (3) Vasomotor symptoms such as sweats and hot flushes commonly commence around the time of the menopause. In the majority of cases urogenital dysfunction does not become a problem until a decade later. Endogenous estrogens decline during the climacteric and the fall of estradiol levels from the time of onset of vasomotor symptoms until commencement of urogenital problems cannot be disregarded. In other words, it seems as if urogenital integrity can be maintained at lower estrogen levels than those required to resist vasomotor symptoms and conserve bone mass. Further evidence for this concept is achieved from numerous clinical studies in which various estrogens have been administered both orally and vaginally to elderly women with signs of urogenital atrophy which have resulted in amelioration. Such an alleviation of urogenital symptoms can be achieved without provoking endometrial growth.
Department of Obstetrics and Gynaecology, Uppsala University Hospital, Sweden.
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Heimer
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Samsioe
D000287:Administration, Topical; D000367:Age Factors; D000368:Aged; D001284:Atrophy / Q000188:drug therapy; D003556:Cystitis / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D004958:Estradiol / Q000008:administration & dosage* / Q000172:deficiency / Q000494:pharmacology; D004967:Estrogens / Q000008:administration & dosage* / Q000172:deficiency / Q000494:pharmacology; D005260:Female; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D014621:Vagina / Q000187:drug effects; D014623:Vaginal Diseases / Q000188:drug therapy* / Q000473:pathology
D004967:Estrogens; D004958:Estradiol