Logrank, play the winner, power and ethics.
We show by simulation and numerical integration techniques that power is largely unaffected by play the winner strategies in a typical chronic disease mortality trial utilizing the logrank test. This raises the issue of the ethics of equal allocation in such a setting.
Hallstrom
A
A
Department of Biostatistics, University of Washington, Seattle 98105, USA.
Brooks
M M
MM
Peckova
M
M
D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D017147:Defibrillators, Implantable; D004992:Ethics, Medical; D006801:Humans; D015233:Models, Statistical; D018579:Patient Selection; D011209:Power, Psychological; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D016019:Survival Analysis; D017180:Tachycardia, Ventricular / Q000401:mortality / Q000628:therapy
D000889:Anti-Arrhythmia Agents