Functional observational battery comparing effects of ethanol, 1,1,1-trichloroethane, ether, and flurothyl.
Several recent reports have demonstrated that acute solvent exposure in animals produces a profile of neurobehavioral effects similar to that of classical CNS depressant drugs such as the barbiturates and ethanol. The present investigation further delineated the behavioral pharmacology of three solvents [1,1,1-trichloroethane (TCE), ether, and flurothyl] using a functional observational battery (FOB) composed of 21 qualitative and quantitative measures of behavior. The profiles of acute effects produced by TCE and ether were similar to one another and similar to the profile of effects produced by the IP administration of ethanol. This profile of depressant effects included changes in posture, decreased arousal, disturbances in gait, decreased forelimb grip strength, increased landing foot splay, and impaired psychomotor coordination. Flurothyl exposure also produced dose-related effects on many of the measures in the FOB; however, unlike the depressant vapors, flurothyl did not affect measures of muscle tone and equilibrium such as forelimb grip strength and landing foot splay, or measures of sensorimotor reactivity, including the touch response and tail pinch response. In addition, flurothyl produced handling-induced convulsions in some mice. Recovery from the acute effects of these vapors was rapid and began within minutes of removal from the exposure chamber. These results provide further evidence that exposure to certain solvents produces a profile of reversible effects qualitatively similar to that produced by depressant drugs and alcohol, and that the FOB can be used to compare and contrast profiles of depressant and excitatory effects of inhalants.
Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0613, USA.
S E
SE
Bowen
J L
JL
Wiley
E B
EB
Evans
M E
ME
Tokarz
R L
RL
Balster
D000818:Animals; D001143:Arousal / Q000187:drug effects; D001341:Autonomic Nervous System / Q000187:drug effects* / Q000502:physiology; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D000431:Ethanol / Q000633:toxicity*; D004986:Ether / Q000633:toxicity*; D005481:Flurothyl / Q000633:toxicity*; D006234:Handling, Psychological; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009129:Muscle Tonus / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology; D012997:Solvents; D014110:Touch; D014240:Trichloroethanes / Q000633:toxicity*
D012997:Solvents; D014240:Trichloroethanes; D004986:Ether; C024566:1,1,1-trichloroethane; D000431:Ethanol; D005481:Flurothyl