Effect of ovariectomy on magnetic resonance T2* in rat femur.
Measurements have been made in the rat femur in vivo and ex vivo by using an asymmetric spin echo technique of T2(1), the susceptibility contribution to T2*. The trabecular spacing in this study in rat bone is considerably less than in previous studies in the human. A significant increase in T2(1) was seen in vivo 3 mm proximal to the growth plate with ovariectomy (a model of osteopenia), from 8.1 +/- 0.7 to 10.0 +/- 0.6 ms. Parallel changes in trabecular bone mineral density measured by quantitative computed tomography were found. T2(1) was higher in living bones than in the same bones measured post mortem.
Checkley
D
D
Department of Vascular Inflammatory and Musculoskeletal Research, Zeneca Pharmaceuticals, Macclesfield, Cheshire, United Kingdon.
Millest
A J
AJ
Johnstone
D
D
Waterton
J C
JC
D015502:Absorptiometry, Photon; D000818:Animals; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000473:pathology; D005260:Female; D005269:Femur / Q000033:anatomy & histology*; D009682:Magnetic Resonance Spectroscopy; D010052:Ovariectomy; D051381:Rats