[Cytokine production during the development and correction of an immunodeficiency in experimental tuberculosis].
The authors investigated spontaneous and induced secretion of cytokins at different stages of generalized tuberculosis. In the development of infection there were inhibited IL-2 synthesis in response to ConA, emerging activity of PNO-alpha in response to the inductors in blood serum and culture of peritoneal macrophages, enhanced secretion of IL-6. Complete immunodeficiency was associated with cessation of IL-2 synthesis by splenocytes, elevated production of IL-6 by peritoneal macrophages, low concentrations of PNO-alpha in the serum and peritoneal macrophage cultures. In the treatment of M. bovis-infected mice with antibacterial drugs alone IL-6 secretion by peritoneal macrophages and PNO-alpha activity in the serum were increased. Immunocorrection resulted in marked activation of IL-2 production by splenocytes in response to ConA as well as enhanced synthesis of IL-6 in unstimulated cultures of peritoneal macrophages.
Zabolotnykh
N V
NV
Aleksandrova
A E
AE
Prokop'eva
E D
ED
Pigareva
N V
NV
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D000995:Antitubercular Agents / Q000008:administration & dosage; D003208:Concanavalin A / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D007111:Immunity, Cellular / Q000187:drug effects; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy / Q000276:immunology*; D007376:Interleukin-2 / Q000032:analysis / Q000378:metabolism*; D015850:Interleukin-6 / Q000032:analysis / Q000378:metabolism*; D007538:Isoniazid / Q000008:administration & dosage; D051379:Mice; D009163:Mycobacterium bovis; D012293:Rifampin / Q000008:administration & dosage; D013951:Thymus Hormones / Q000008:administration & dosage; D014376:Tuberculosis / Q000188:drug therapy / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000187:drug effects / Q000378:metabolism*
D000276:Adjuvants, Immunologic; D000995:Antitubercular Agents; D007376:Interleukin-2; D015850:Interleukin-6; D013951:Thymus Hormones; D014409:Tumor Necrosis Factor-alpha; D003208:Concanavalin A; C032805:thymalin; D007538:Isoniazid; D012293:Rifampin