Determination of SB 216469-S during tablet production using near-infrared reflectance spectroscopy.
A near-infrared method was developed for analyzing SB 216469-S tablets at various stages of tablet processing, particularly after (i) high shear granulation, (ii) lubrication, (iii) core tablet compression, and (iv) aqueous film coating. Tablets with three different drug concentrations ranging from 1.5% (w/w) to 6.0% (w/w) were examined along with a placebo. Similarly, moisture levels during the granulation drying process were measured, along with the thickness of the tablet coating. Tablet identification inside blister packaging for clinical supplies was also demonstrated.
Han
S M
SM
SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA.
Faulkner
P G
PG
D002626:Chemistry, Pharmaceutical / Q000379:methods; D002851:Chromatography, High Pressure Liquid; D002867:Chromones / Q000032:analysis / Q000737:chemistry*; D005612:Freeze Drying; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D013607:Tablets
D002867:Chromones; C099870:Rec 15-2739; D013607:Tablets