Intrabulbar infusions of (+/-)S-nitroso-N-acetylpenicillamine and L-arginine induce functional plasticity in the accessory olfactory bulb of female mice.
Infusions of a nitrosothiol, (+/-)S-nitroso-N-acetylpenicillamine or L-arginine into the accessory olfactory bulb (AOB) are capable of causing memory or learning-related synaptic plasticity in female mice. This is consistent with the ability of nitric oxide (NO), released spontaneously or by activation of the endogenous synthesizing system, to enhance a long-lasting increase in gain of AOB synapses; resulting in memory formation for male pheromones without mating. Hemoglobin, a NO scavenger, prevented this memory suggesting, in part, an extracellular action of NO in this functional plasticity.
Department of Physiology, Kochi Medical School, Japan. okerec@dtn.am400gw.kochi-ms.ac.jp
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Okere
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Kaba
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Takahashi
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Higuchi
D000818:Animals; D001120:Arginine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006454:Hemoglobins / Q000494:pharmacology; D007858:Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D008845:Microinjections; D009473:Neuronal Plasticity / Q000187:drug effects*; D009569:Nitric Oxide / Q000096:biosynthesis; D009830:Olfactory Bulb / Q000187:drug effects / Q000502:physiology*; D010396:Penicillamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D010675:Pheromones / Q000494:pharmacology; D011247:Pregnancy; D026423:S-Nitroso-N-Acetylpenicillamine
D006454:Hemoglobins; D010675:Pheromones; D009569:Nitric Oxide; D026423:S-Nitroso-N-Acetylpenicillamine; D001120:Arginine; D010396:Penicillamine