N-alkylvaline levels in globin as a new type of biomarker in risk assessment of alkylating agents.
Adducts with the N-terminal valine of erythrocyte globin can serve as individual biomarkers of systemic and cellular exposure to endogenous and exogenous alkylating agents. In contrast to "detoxification markers" of this kind of mecapturic acids derived from alkylation of glutathione, individual N-alkylations of valine in globin reflect the formally "toxifying" part of the stress due to alkylating agents transformed into the ultimate toxicant. Thus, in contrast to the traditional methods of biological monitoring this approach enables a better evaluation of systemic exposure to reactive agents, adapted more sensibly to the exposure situation over the whole life span of erythrocytes, and it can serve as a specific biomarker of exposure for the purpose of health surveillance in occupational medicine. An individual evaluation of exposures in comparison with the range of corresponding background levels is discussed from the point of view of supplementary risk assessment in medical surveillance of occupationally exposed persons.
BAYER AG, Department of Medicine, Leverkusen, Germany.
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Lewalter
D000181:Acrylonitrile / Q000493:pharmacokinetics / Q000506:poisoning; D000477:Alkylating Agents / Q000032:analysis* / Q000737:chemistry / Q000506:poisoning; D000478:Alkylation; D015415:Biomarkers / Q000032:analysis; D004784:Environmental Monitoring / Q000379:methods*; D004912:Erythrocytes / Q000737:chemistry; D005914:Globins / Q000737:chemistry*; D006261:Headache / Q000139:chemically induced; D006801:Humans; D006834:Hydrazines / Q000737:chemistry / Q000493:pharmacokinetics; D008297:Male; D013058:Mass Spectrometry; D009325:Nausea / Q000139:chemically induced; D016273:Occupational Exposure / Q000032:analysis*; D018570:Risk Assessment; D013463:Sulfuric Acid Esters / Q000097:blood; D014633:Valine / Q000031:analogs & derivatives* / Q000097:blood* / Q000737:chemistry
D000477:Alkylating Agents; D015415:Biomarkers; D006834:Hydrazines; D013463:Sulfuric Acid Esters; C029424:hydrazine; D005914:Globins; D014633:Valine; C007482:dimethyl sulfate; D000181:Acrylonitrile