Primaquine analogues that are potent anti-Trypanosoma cruzi agents in a mouse model.
Seventy-seven primaquine analogues were evaluated for their effectiveness in reducing the parasitaemias in female albino mice (aged 4-6 weeks) which had been infected with a Brazilian strain of Trypanosoma cruzi 15 days earlier. Of the analogues tested, 23 were more effective than the reference drug, nifurtimox, and one was > 14-fold as effective as the standard and almost four times as active as primaquine itself. Certain members of the series tested warrant further evaluation.
Kinnamon
K E
KE
Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC 20307-5100, USA.
Poon
B T
BT
Hanson
W L
WL
Waits
V B
VB
D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy*; D002626:Chemistry, Pharmaceutical; D005260:Female; D051379:Mice; D011319:Primaquine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014349:Trypanosoma cruzi
D014344:Trypanocidal Agents; D011319:Primaquine