Cerebral hypoxia after hyperventilation causes "re-build-up" phenomenon and TIA in childhood moyamoya disease. A near-infrared spectroscopy study.
Near-infrared spectroscopy was used to monitor the sequential changes in the cerebral oxygenation state during and after hyperventilation in two children with moyamoya disease. Hyperventilation induced the build-up phenomenon and a decrease in the concentration of oxy-hemoglobin ([oxy-Hb]) and total hemoglobin ([t-Hb]). The termination of hyperventilation was followed by partial recovery of [oxy-Hb] and [t-Hb]. Subsequently, however, [oxy-Hb] and [t-Hb] decreased again and cytochrome oxidase was reduced. These impairments of the cerebral hemodynamics and oxygen metabolism were closely associated with the re-build-up phenomenon on EEG and with transient ischemic attacks (TIA). The present study implies that cerebral hypoxia after hyperventilation is closely related to the re-build-up phenomenon and ischemic attacks in children with moyamoya disease.
Department of Neurosurgery, Hokkaido University School of Medicine, Sapporo, Japan.
S
S
Kuroda
K
K
Houkin
Y
Y
Hoshi
M
M
Tamura
K
K
Kazumata
H
H
Abe
D000714:Anastomosis, Surgical; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D005260:Female; D006801:Humans; D006985:Hyperventilation / Q000150:complications* / Q000503:physiopathology; D002534:Hypoxia, Brain / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D002546:Ischemic Attack, Transient / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D009072:Moyamoya Disease / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D019265:Spectroscopy, Near-Infrared