Iron accumulation in tissues of magnesium-deficient rats with dietary iron overload.
The mineral imbalances in magnesium-deficient rats with dietary iron overload were studied. Forty-four male Wistar rats were divided into six groups and fed six diets, two by three, fully crossed: magnesium adequate or deficient, and iron deficient, adequate, or excess. The concentrations of iron, magnesium, calcium, and phosphorus in tissues of the rats were measured. The results were as follows: (1) The excess iron intake reinforced the iron accumulation in liver and spleen of magnesium deficient rats; (2) The saturation of iron binding capacity was enormously elevated in the magnesium deficient rats fed excess iron; and (3) Dietary iron deprivation diminished the degree of calcium deposition in kidney of magnesium deficient rats. These results suggest that magnesium-deprived rats have abnormal iron metabolism losing homeostatic regulation of plasma iron, and magnesium deficient rats with dietary iron overload may be used as an experimental hemochromatosis model.
Kimura
M
M
Department of Social Medicine, Graduate School of Medicine, Kyoto University, Konoecho Yoshida Sakyoku, Japan.
Yokoi
K
K
D000704:Analysis of Variance; D000818:Animals; D001827:Body Height / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D004032:Diet; D004195:Disease Models, Animal; D004435:Eating / Q000502:physiology; D005527:Food, Fortified; D006432:Hemochromatosis / Q000209:etiology; D007501:Iron / Q000008:administration & dosage / Q000097:blood*; D008275:Magnesium Deficiency / Q000097:blood*; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
D010281:Parathyroid Hormone; D010758:Phosphorus; D007501:Iron; D002118:Calcium