Dieulafoy's disease: endosonographic detection and endosonography-guided treatment.
BACKGROUND
To investigate whether endosonography can help in the detection and treatment of Dieulafoy's disease, we examined eight patients with suspicion of Dieulafoy's disease.


METHODS
Between December 1992 and April 1995, eight patients were referred because of suspicion of Dieulafoy's disease. Seven presented with upper gastrointestinal bleeding and one with a tiny ulcer. In all eight patients the stomach was examined with an Olympus GF-UM20 echoendoscope. The stomach was filled with 200 to 400 ml of water after which the body, fundus, and cardia were carefully visualized.


RESULTS
In all eight patients a clearly visible, relatively large caliber (2 to 3 mm) vessel was seen to penetrate the muscularis propria and could be followed running through the submucosa for 2 to 4 cm. Subsequently four patients received sclerotherapy, three under endosonographic guidance. Follow-up of all patients (median 10 months), showed recurrent bleeding in two patients, 3 and 5 months after sclerotherapy. One was then diagnosed with a duodenal ulcer and one with recurrent bleeding from the Dieulafoy's lesion.


CONCLUSIONS
Endosonography is useful in the detection of Dieulafoy's disease in patients with unexplained upper gastrointestinal bleeding. Sclerotherapy can be performed during the same procedure, with endosonography-guided injection of the sclerosing agent near the abnormal vessel.
Department of Gastroenterology and Hepatology, University of Amsterdam, The Netherlands.
P
P
Fockens
J
J
Meenan
H M
HM
van Dullemen
C J
CJ
Bolwerk
G N
GN
Tytgat
D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D019160:Endosonography / Q000295:instrumentation / Q000379:methods; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000628:therapy*; D020699:Gastroscopes; D005773:Gastroscopy / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015911:Sclerotherapy / Q000379:methods; D012680:Sensitivity and Specificity