A fatal case of methotrimeprazine overdose.
Fatal ingestion of methotrimeprazine is unusual, and while therapeutic drug levels are established as concentrations between 0.02 to 0.14 mg/L, fatal levels are not. The following describes a case of fatal suicidal ingestion of methotrimeprazine in which the measured concentration of methotrimeprazine in the blood was 4.1 mg/L. In addition, the major metabolites of methotrimeprazine, desmethylmethotrimeprazine, and methotrimeprazine sulfoxide were also measured at 2.0 and 1.8 mg/L, respectively. Methotrimeprazine and its metabolites were also measured in urine, bile, and vitreous humor. These results are compared with other case reports of methotrimeprazine fatalities reported in the literature.
Department of Justice, Province of Newfoundland and Labrador, Health Sciences Center, St. John's, Canada.
S P
SP
Avis
M D
MD
Holzbecher
D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000506:poisoning*; D002849:Chromatography, Gas / Q000379:methods; D017809:Fatal Outcome; D005554:Forensic Medicine; D006801:Humans; D008297:Male; D008728:Methotrimeprazine / Q000493:pharmacokinetics / Q000506:poisoning*; D013405:Suicide
D018712:Analgesics, Non-Narcotic; D008728:Methotrimeprazine