Torsades de pointes from terfenadine and sotalol given in combination.
A patient receiving sotalol developed recurrent torsades de pointes following the addition of terfenadine (Seldane) to her medical regimen. A 71-year-old woman with a history of atrial fibrillation successfully suppressed with sotalol, 80 mg bid, was started on terfenadine, 60 mg bid. Eight days later, she developed repeated self-terminating episodes of torsades de pointes. Sotalol and terfenadine were discontinued, and no further arrhythmia was observed after 72 hours of temporary pacing was discontinued.
Feroze
H
H
Cardiology Division, John Dempsey Hospital, University of Connecticut Health Center, Farmington 06030, USA.
Suri
R
R
Silverman
D I
DI
D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects; D001281:Atrial Fibrillation / Q000188:drug therapy; D004347:Drug Interactions; D004562:Electrocardiography; D005260:Female; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D013015:Sotalol / Q000008:administration & dosage / Q000009:adverse effects*; D016593:Terfenadine / Q000008:administration & dosage / Q000009:adverse effects*; D016171:Torsades de Pointes / Q000139:chemically induced* / Q000175:diagnosis
D000889:Anti-Arrhythmia Agents; D006634:Histamine H1 Antagonists; D016593:Terfenadine; D013015:Sotalol