PRAD1/Cyclin D1 gene overexpression in mantle cell lymphoma.
The t(11;14) (q13;q32) translocation and its molecular counterpart Bcl-1 rearrangement are consistent features of mantle cell lymphoma (MCL). This translocation activates the PRAD1/cyclin D1 gene that is considered to be the Bcl-1 oncogene. PRAD1/cyclin D1 gene overexpression is closely associated with MCL. The PRAD1/cyclin D1 protein is localized to the nucleus, and the strong correlation between PRAD1/cyclin D1 and MCL is also found in the protein level. This finding indicates that PRAD1/cyclin D1 expression is a highly specific and sensitive molecular marker for MCL. This gene may function as an oncogene in the malignant transformation of cells.
Oka
K
K
The Second Department of Internal Medicine, Mie University School of Medicine, Edobashi Tsu, Japan.
Ohno
T
T
Yamaguchi
M
M
Mahmud
N
N
Miwa
H
H
Kita
K
K
Shiku
H
H
Shirakawa
S
S
D019938:Cyclin D1; D016213:Cyclins / Q000096:biosynthesis* / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D015513:Oncogene Proteins / Q000096:biosynthesis* / Q000235:genetics*; D014178:Translocation, Genetic
D016213:Cyclins; D015513:Oncogene Proteins; D019938:Cyclin D1