Prolactin regulates IL-1 alpha, IFN-gamma and IL-4 release from mouse splenocytes stimulated with some staphylococcal and streptococcal toxins.
This study investigates changes in IL-1 alpha, IFN-gamma and IL-4 from mouse splenocytes stimulated with Staphylococcal Protein A (PA), or Toxic Shock Syndrome Toxin-1 (TSST-1), or Streptococcal lysin S (SLS) after exposure to Prolactin (PRL). In the presence of PRL, IL-1 alpha and IFN-gamma induction by PA-stimulated splenocytes was reduced by 74% and 25% respectively. On the other hand, IL-4 release was enormously increased. The ability of TSST-1 to induce IFN-gamma release was decreased by 32% after PRL. IL-1 alpha and IL-4 was unchanged compared to controls. In the presence of PRL, IFN-gamma release from splenocytes stimulated with SLS, was increased by 60%, while no changes were shown in IL-1 alpha and IL-4 release.
Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, Seconda Università degli Studi di Napoli, Italy.
P
P
Scarfogliero
M
M
Vitiello
M
M
Galdiero
F
F
Brancaccio
L
L
Sommese
D000818:Animals; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D004305:Dose-Response Relationship, Drug; D004768:Enterotoxins / Q000494:pharmacology*; D007371:Interferon-gamma / Q000378:metabolism*; D007375:Interleukin-1 / Q000378:metabolism*; D015847:Interleukin-4 / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011388:Prolactin / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D013205:Staphylococcal Protein A / Q000494:pharmacology*; D013301:Streptolysins / Q000494:pharmacology*; D018089:Superantigens
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D004768:Enterotoxins; D007375:Interleukin-1; D013205:Staphylococcal Protein A; D013301:Streptolysins; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal; C026050:streptolysin S; D015847:Interleukin-4; D007371:Interferon-gamma; D011388:Prolactin