Benzoylalanine analogues as inhibitors of rat brain kynureninase and kynurenine 3-hydroxylase.
Pharmacia, R&D-CNS, Milano, Italy.
A
A
Giordani
L
L
Corti
M
M
Cini
M
M
Marconi
A
A
Pillan
R
R
Ferrario
R
R
Schwarcz
P
P
Guidetti
C
C
Speciale
M
M
Varasi
D000409:Alanine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001565:Benzoates / Q000737:chemistry / Q000494:pharmacology*; D001921:Brain / Q000201:enzymology*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006867:Hydrolases / Q000037:antagonists & inhibitors*; D007700:Kinetics; D050601:Kynurenine 3-Monooxygenase; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors*; D009525:Niacin / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
D001565:Benzoates; D004791:Enzyme Inhibitors; C071261:nicotinylalanine; D009525:Niacin; D006899:Mixed Function Oxygenases; D050601:Kynurenine 3-Monooxygenase; D006867:Hydrolases; C021480:kynureninase; D000409:Alanine