The absence of any pre-emptive analgesic effect for non-steroidal anti-inflammatory drugs.
Pre-emptive analgesic efficacy of the non-steroidal anti-inflammatory drug, diclofenac sodium, was tested in 21 young, fit, patients undergoing third molar extractions in a double-blind, randomised, cross-over, trial. Pain scores and mouth opening were observed for 1 week after the operation and these did not show any differences following pre- and postoperative oral administration of diclofenac sodium 100 mg (P > 0.05). There were no differences in the patients' preference for the two methods of treatment (P > 0.05). The study suggests that the non-steroidal anti-inflammatory drug diclofenac sodium does not cause any significant pre-emptive analgesic effects in the dose administered.
Department of Oral Medicine & Oral Surgery, School of Dentistry, University of Otago, Dunedin, New Zealand.
J B
JB
Bridgman
T G
TG
Gillgrass
M
M
Zacharias
D000328:Adult; D000698:Analgesia; D000704:Analysis of Variance; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D018592:Cross-Over Studies; D004008:Diclofenac / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010147:Pain Measurement; D010149:Postoperative Pain / Q000209:etiology / Q000517:prevention & control*; D014081:Tooth Extraction / Q000009:adverse effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac