[Clinical pilot study of the myogenic effects of flupirtine in comparison to tetrazepam and placebo].
The effects of flupirtine (CAS 56995-20-1, D-9998, Katadolon) on muscle force and related electromyographic (EMG) activity has been assessed in comparison to tetrazepam and placebo in 12 healthy male volunteers after oral single-dose administration and under steady-state conditions. Muscle functions primarily reflecting dynamic daily demands remained unaffected under flupirtine in contrast to tetrazepam, the latter exhibiting the typical signs of increased (co-)innervation which can be interpreted as a compensation of a decrease of muscle force. Under conditions that serve as a model for static-spastic situations, flupirtine showed a decrease, tetrazepam a typical increase in the force parameter. Under the same conditions, a decrease of the EMG-amplitude was observed for flupirtine and, to a lesser extent, for tetrazepam as well. With respect to its muscle relaxing property, flupirtine differs both, quantitatively and qualitatively from tetrazepam, which has shown effects common for benzodiazepines.
Lobisch
M
M
Konzernforschung der ASTA Medica AG, Frankfurt/Main.
Schaffler
K
K
Wauschkuhn
H
H
Nickel
B
B
D000328:Adult; D000631:Aminopyridines / Q000494:pharmacology*; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology*; D004576:Electromyography / Q000187:drug effects; D006181:H-Reflex / Q000187:drug effects; D006801:Humans; D007537:Isometric Contraction / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D018482:Muscle, Skeletal / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010865:Pilot Projects
D000631:Aminopyridines; D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D009125:Muscle Relaxants, Central; D018696:Neuroprotective Agents; D001569:Benzodiazepines; C005245:tetrazepam; C034161:flupirtine