A clinico-immunohistochemical study of giant cell glioblastoma.
We have reported 7 cases of giant cell glioblastoma. All cases died within 14 months despite aggressive treatment. By immunohistochemical staining, lymphocyte infiltration was found in 6 cases. GFAP and vimentin stained positive in all cases. The MIB-1 positive rate was 13.8-90% (average, 34.9%); small and mononucleated giant cells stained more than multinucleated and monstrous cells. It was concluded that this tumor can be highly malignant and its degree of malignancy is determined by the biological behavior of the mononucleated giant cells and small cells.
Department of Neurosurgery, Tokyo Women's Medical College.
M C
MC
Huang
O
O
Kubo
Y
Y
Tajika
K
K
Takakura
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D005909:Glioblastoma / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007427:Intracranial Pressure; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008875:Middle Aged; D013194:Staining and Labeling; D014746:Vimentin / Q000032:analysis
D005904:Glial Fibrillary Acidic Protein; D019394:Ki-67 Antigen; D014746:Vimentin