Fast 3D functional magnetic resonance imaging at 1.5 T with spiral acquisition.
A new method to perform rapid 3D fMRI in human brain is introduced and evaluated in normal subjects, on a standard clinical scanner at 1.5 Tesla. The method combines a highly stable gradient echo technique with a spiral scan method, to detect brain activation related changes in blood oxygenation with high sensitivity. A motor activation paradigm with a duration of less than 5 min, performed on 10 subjects, consistently showed significant changes in signal intensity in the area of the motor cortex. In all subjects, these changes survived high statistical thresholds.
Yang
Y
Y
Laboratory of Diagnostic Radiology Research, OIR, National Institutes of Health, Bethesda, MD 20892, USA.
Glover
G H
GH
van Gelderen
P
P
Mattay
V S
VS
Santha
A K
AK
Sexton
R H
RH
Ramsey
N F
NF
Moonen
C T
CT
Weinberger
D R
DR
Frank
J A
JA
Duyn
J H
JH
D001921:Brain / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009044:Motor Cortex / Q000473:pathology