A Shigella flexneri invasion plasmid gene, ipgH, with homology to IS629 and sequences encoding bacterial sugar phosphate transport proteins.
Sequences representing the 2684 bp flanking the ipaH4.5 gene on the invasion plasmid of Shigella flexneri 5 indicate an unusual fusion gene, designated ipgH, in which the first 27 amino acids (aa) are identical to ORF2 of IS629. The aa sequence encoded by the remainder of ipgH bears significant homology to Escherichia coli and to Salmonella typhimurium GlpT and UhpT proteins and to the S. typhimurium PgtP protein, which are involved in the uptake of high-energy sugar phosphates from an external source.
Department of Enteric Infections, Walter Reed Army Institute of Research, Washington, DC 20307-5100, USA. batmm@wrair.emhl.army.mil
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Venkatesan
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Alexander
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Fernandez-Prada
D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics; D005798:Genes, Bacterial / Q000235:genetics*; D005822:Genetic Vectors / Q000235:genetics*; D008969:Molecular Sequence Data; D009004:Monosaccharide Transport Proteins / Q000235:genetics*; D016366:Open Reading Frames / Q000235:genetics*; D027361:Organic Anion Transporters; D012486:Salmonella typhimurium / Q000235:genetics; D012763:Shigella flexneri / Q000235:genetics*
D001426:Bacterial Proteins; D002352:Carrier Proteins; C102185:IpgH protein, Shigella flexneri; D009004:Monosaccharide Transport Proteins; D027361:Organic Anion Transporters; C056780:PgtP protein, Salmonella typhimurium