Plasma N tau-methylhistidine concentration is a sensitive index of myofibrillar protein degradation during starvation in rats.
Urinary excretion of N tau-methylhistidine (MeHis) in rats was linearly elevated by starvation for 2 days. Plasma concentration of MeHis on day 1 and day 2 of starvation were increased 2.4- and 2.6-fold, respectively. The amount of released MeHis from the isolated muscles into medium during a 2-h incubation period was increased with starvation corresponded to the plasma MeHis concentration. The results of this study suggest that plasma MeHis is a sensitive index of myofibrillar protein degradation.
Department of Bioscience and Technology, Iwate University, Japan.
T
T
Nagasawa
F
F
Yoshizawa
N
N
Nishizawa
D000818:Animals; D001835:Body Weight / Q000502:physiology; D008762:Methylhistidines / Q000097:blood* / Q000652:urine; D009124:Muscle Proteins / Q000378:metabolism*; D009132:Muscles / Q000033:anatomy & histology / Q000378:metabolism; D009929:Organ Size / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012680:Sensitivity and Specificity; D013217:Starvation / Q000097:blood* / Q000378:metabolism* / Q000652:urine
D008762:Methylhistidines; D009124:Muscle Proteins; C028118:3-methylhistidine