The beneficial effect of the prostacyclin analogue (OP 2507) on rat liver transplantation subjected to an extended anhepatic phase.
We investigated the effect of a prostacyclin analogue (OP 2507) on PVG (RT1c) recipients subjected to an extended anhepatic phase (AH) and transplanted orthotopically with PVG livers. All of the animals that underwent orthotopic liver transplantation (OLT) with a 20-min AH survived for 1 week with or without OP 2507, (OP) treatment (10/10, 100%). When the AH was lengthened to 45 min, the 1-week survival rate of recipients was poor in the OP-untreated groups (1/10, 10%). Treatment of the recipient with OP 2507, 0.15 micrograms/kg per minute for 30 min, prior to the 45-min AH substantially improved 1-week survival (5/6, 83.3%, P < 0.05). The serum TNF-alpha level at day 1 in OP-treated animals that underwent OLT with a 45-min AH was significantly lower than that in animals with 45-min AH OLT without OP treatment. We conclude that OP 2507 treatment has potential usefulness as a perioperative treatment when the AH is extended during OLT.
Goto
S
S
Department of Surgery, University of Queensland, Herston, Brisbane, Australia.
Shimizu
Y
Y
Lord
R
R
Vari
F
F
Edwards-Smith
C
C
Chiba
S
S
Kamada
N
N
D000818:Animals; D011464:Epoprostenol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006084:Graft Rejection / Q000517:prevention & control*; D006085:Graft Survival; D016031:Liver Transplantation; D008297:Male; D051381:Rats; D014184:Transplantation, Homologous; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D014409:Tumor Necrosis Factor-alpha; C049453:OP 2507; D011464:Epoprostenol