Bioavailability to rats of 14C-lindane residues in stored potato tubers.
Potato tubers were applied with radiolabelled lindane (U-14C gamma- 1,2,3,4,5,6-hexachlorocyclohexane) at three dose levels 30, 150, and 300 ppm and stored for 30, 60 and 90 days at room temperature. The data revealed that lindane penetrated into the pulp tissues through the epidermal layer. The amounts recovered in the peel were found to increase with a greater storage period up to 60 days followed by a drop at 90 days. On the other hand, there was a slight increase in radioactivity in the pulp tissue from 30 to 60 days followed by significant increase after 90 days. The incorporation of the compound in the tubers was dose independent. Methanol extraction showed binding of about 8.1% and 5.8% of the applied dose in peel and pulp tissues, respectively. The insecticide was found to be bioavailable when rats health hazard. It is therefore, desirable to demonstrate that the quantity of the terminal residues may be safe for the consumer. In the present investigation an attempt was made to determine the fate and bioavailability of lindane when applied to stored potato tubers.
Mostafa
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Radioisotopes Dept., Atomic Energy Authority, Dokki, Cairo, Egypt.
Mostafa
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Aly
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Afifi
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LM
D000821:Animal Feed; D000818:Animals; D001682:Biological Availability; D002250:Carbon Radioisotopes; D004305:Dose-Response Relationship, Drug; D004356:Drug Storage; D004817:Epidermis / Q000378:metabolism*; D005506:Food Contamination; D001556:Hexachlorocyclohexane / Q000493:pharmacokinetics*; D007306:Insecticides / Q000493:pharmacokinetics*; D007553:Isotope Labeling; D008297:Male; D010573:Pesticide Residues / Q000378:metabolism / Q000493:pharmacokinetics*; D051381:Rats; D012869:Skin Absorption; D011198:Solanum tuberosum / Q000378:metabolism*
D002250:Carbon Radioisotopes; D007306:Insecticides; D010573:Pesticide Residues; D001556:Hexachlorocyclohexane