EM523L, a nonpeptide motilin agonist, stimulates gastric emptying and pancreatic polypeptide secretion.
We investigated the efficacy and the mechanism of action of EM523L, a nonpeptide motilin agonist (motilide), on the stimulation of gastric emptying and on the release of gut peptides after ingestion of a solid meat in normal controls (n = 8) and in diabetic patients (n = 8) with signs of neuropathy. A dose of 2 mg EM523L was administered IV over 15 min just after ingestion of a solid meal (200 kcal Gastric emptying was measured by a radionuclide technique. EM523L accelerated gastric emptying and markedly augmented postprandial pancreatic polypeptide (PP) response in both normal control and diabetic patients. This may suggest the mediation of the Vagal-cholinergic pathway to accelerate gastric emptying. The present study offers a promising therapeutic potential of the motilide in gastrointestinal motility disorders like those observed in diabetics mellitus.
Okano
H
H
Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
Inui
A
A
Ueno
N
N
Morimoto
S
S
Ohmoto
A
A
Miyamoto
M
M
Aoyama
N
N
Nakajima
Y
Y
Baba
S
S
Kasuga
M
M
D000328:Adult; D000368:Aged; D003920:Diabetes Mellitus / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D003929:Diabetic Neuropathies / Q000175:diagnosis; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D005069:Evaluation Studies as Topic; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009037:Motilin / Q000819:agonists*; D010191:Pancreatic Polypeptide / Q000097:blood*
D005765:Gastrointestinal Agents; D009037:Motilin; D010191:Pancreatic Polypeptide; D004917:Erythromycin; C061752:EM 523