The kinetics of skin thinning induced by topical fluticasone propionate 0.05% cream in volunteer subjects.
Fluticasone propionate (FP) 0.05% (CutivateTM) cream is a novel corticosteroid used for the treatment of corticosteroid-responsive dermatoses. To date there are no published data concerning its effect on cutaneous atrophy. This randomized, double-blind study of 40 volunteer subjects was performed to investigate the kinetics of skin thinning induced by topical 0.05% FP cream vs. placebo after once-daily application for 2-8 weeks. The results of this study showed no significant effect on the skin thickness of subjects after 8 weeks' treatment with 0.05% FP cream compared with placebo.
Department of Dermatology, University of Wales College of Medicine, Heath Park, Cardiff, UK.
P J
PJ
Dykes
R
R
Marks
S
S
Hill
C
C
Mills
R
R
Eastwood
D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000368:Aged; D000730:Androstadienes / Q000009:adverse effects*; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001284:Atrophy / Q000139:chemically induced; D004311:Double-Blind Method; D000068298:Fluticasone; D006801:Humans; D007700:Kinetics; D008875:Middle Aged; D012867:Skin / Q000187:drug effects / Q000473:pathology*
D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D000068298:Fluticasone