Tryptophan hydroxylase activity in serotonin producing mast cells. Dependence on intracellular iron concentration manipulated by permeable chelators.
Hasegawa
H
H
Department of Bioscience, Nishi-Tokyo University, Yamanashi, Japan.
Iida
Y
Y
Oguro
K
K
Kojima
M
M
Ichiyama
A
A
D000818:Animals; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D017077:Culture Media, Conditioned; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D006427:Hemin / Q000494:pharmacology; D006834:Hydrazines / Q000494:pharmacology; D007501:Iron / Q000378:metabolism*; D007502:Iron Chelating Agents / Q000494:pharmacology*; D007700:Kinetics; D015471:Leukemia, Basophilic, Acute; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013154:Spleen; D014364:Tryptophan / Q000378:metabolism; D014365:Tryptophan Hydroxylase / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D017077:Culture Media, Conditioned; D004791:Enzyme Inhibitors; D006834:Hydrazines; D007502:Iron Chelating Agents; D012701:Serotonin; D006427:Hemin; D014364:Tryptophan; C004297:3-hydroxybenzylhydrazine; D007501:Iron; D014365:Tryptophan Hydroxylase