Short-term sucralfate administration does not alter the absorption of metronidazole in healthy male volunteers.
BACKGROUND
An oral triple therapy using sucralfate instead of a bismuth to eradicate Helicobacter pylori has yielded worse results than those obtained with conventional oral triple therapies. To date, the effect of sucralfate on the pharmacokinetics of nitroimidazolic compounds used in triple therapy such as with metronidazole is unknown. The aim of this study was to investigate the effect of a 5-day administration period of sucralfate (2 g b.i.d.) on metronidazole pharmacokinetics.


METHODS
Fourteen healthy male volunteers were selected. The study had an open randomized 2-period crossover design with a 14-day washout period between the phases. The plasma concentration of metronidazole and its hydroxy-metabolite were measured by reverse-phase HPLC with ultraviolet detection.


RESULTS
No statistically significant difference was observed in any of the pharmacokinetic parameters studied in the absence and presence of sucralfate.


CONCLUSIONS
Our results clearly indicate that short-term treatment with sucralfate in healthy volunteers does not alter the extent or the rate of metronidazole absorption, and does not affect metronidazole clearance.
Department of Pharmacology Medical School, Federal University of Ceará, Fortaleza, Brazil.
M E
ME
Moraes
M de A
Mde A
Pierossi
M O
MO
Moraes
F F
FF
Bezerra
C M
CM
Da Silva
H B
HB
Dias
M N
MN
Muscará
G
G
De Nucci
J
J
Pedrazzoli Júnior
D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000994:Antitrichomonal Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D016480:Helicobacter pylori / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013392:Sucralfate / Q000008:administration & dosage / Q000494:pharmacology*
D000897:Anti-Ulcer Agents; D000994:Antitrichomonal Agents; D008795:Metronidazole; D013392:Sucralfate