Glutathione and cysteine in HIV-infected hemophiliacs.
A cross-sectional study was designed to determine whether plasma concentrations of glutathione and cysteine in HIV-infected hemophiliacs vary according to the progression of the disease and to compare them with those obtained in HIV negative hemophiliacs. Cysteine, total glutathione and glutathione disulphide were measured in plasma of HIV-infected hemophiliacs at different stages of HIV infection and in plasma of HIV-negative hemophiliacs. CD4 and CD8 T-cell counts, leukocyte and lymphocyte counts, beta 2-microglobulin and p24 antigen values were recorded for HIV positive hemophiliacs at the time of the study. The hemophiliac HIV-positive group showed a decrease in total glutathione levels (-18%) and an increase of glutathione disulphide (8.18 vs. 14.90%) compared to the HIV-negative group. The cysteine levels found in HIV-positive hemophiliacs were not different from those found in the HIV-negative group. There were no differences with statistical significance in total glutathione, glutathione disulphide and cysteine among HIV-infected hemophiliacs according to the different clinical stage of the disease (AIDS vs. non-AIDS). The interest of evaluating plasma concentrations of glutathione and cysteine in HIV-infected patients is limited from the point of view of considering them as markers of progression of the disease. Interest in a therapeutic strategy designed to replenish or normalize glutathione plasma levels is also limited.
Department of Haemophilia, Ciudad Sanitaria Valley de Hebrón, Barcelona, Spain.
R M
RM
López Galera
J C
JC
Juárez Giménez
J B
JB
Montoro Ronsano
R M
RM
Segura Cardona
M A
MA
Arbós Via
C
C
Altisent Roca
J M
JM
Tusell Puigbert
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood; D000293:Adolescent; D000328:Adult; D003545:Cysteine / Q000097:blood*; D018450:Disease Progression; D005260:Female; D005978:Glutathione / Q000031:analogs & derivatives / Q000097:blood*; D019803:Glutathione Disulfide; D006679:HIV Seropositivity / Q000097:blood* / Q000150:complications; D006467:Hemophilia A / Q000097:blood* / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged
D005978:Glutathione; D003545:Cysteine; D019803:Glutathione Disulfide