Thyroid hormone therapy in patients infected with human immunodeficiency virus: a clinical approach to treatment.
Clinical, biochemical and immunological evidence suggests that thyroid hormones would be helpful in human immunodeficiency virus disease either by itself or as an adjuvant to present-day therapies. During prolonged non-thyroidal illnesses such as human immunodeficiency virus disease, thyroid function tests could be misleading or difficult to interpret. Human immunodeficiency virus disease could mask a hypothyroid state which might be intracellular. Thyroid hormones are the only consistent natural stimulator of both the primary lymphoid tissue (thymus and bone marrow) and secondary lymphoid tissue (circulating lymphocytes, spleen and lymph nodes). There is abundant historical precedent for using thyroid hormone as a safe pharmacological agent against human immunodeficiency virus disease.
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D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D004361:Drug Tolerance; D005221:Fatigue / Q000188:drug therapy; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D008954:Models, Biological; D012449:Safety; D013960:Thyroid Function Tests; D013963:Thyroid Hormones / Q000009:adverse effects / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D013963:Thyroid Hormones