Grouped papules in Hurler-Scheie syndrome.
In a patient with Hurler-Scheie syndrome, a type of mucopolysaccharidosis (I H/S), an initial presentation was grouped papules on the extensor surfaces on the upper portions of the arms and legs. Other physical findings included progressive flexion contractures and mild developmental delay. The patient had deficient alpha-L-induronidase activity, and electron microscopy showed large cytoplasmic vacuoles and lysosomes, consistent with Hurler-Scheie syndrome. Findings of grouped papules have not been previously reported in patients with this syndrome.
Schiro
J A
JA
Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri, USA.
Mallory
S B
SB
Demmer
L
L
Dowton
S B
SB
Luke
M C
MC
D002675:Child, Preschool; D006801:Humans; D008297:Male; D008059:Mucopolysaccharidosis I / Q000150:complications*; D017444:Skin Diseases, Papulosquamous / Q000209:etiology*