Inhibitory effects of natural carotenoids, alpha-carotene, beta-carotene, lycopene and lutein, on colonic aberrant crypt foci formation in rats.
Inhibitory effect of four carotenoids prevalent in human blood and tissues against the formation of colonic aberrant crypt foci was examined in Sprague-Dawley rats. They received three intrarectal doses of N-methylnitrosourea in weak 1, and a daily gavage of de-escalated doses of carotenoids during weeks 2 and 5. Lycopene, lutein, alpha-carotene and palm carotenes (a mixture of alpha-carotene, beta-carotene and lycopene) inhibited the development of aberrant crypt foci quantitated at week 6, but beta-carotene did not. The results suggested that lycopene and lutein in small doses may potentially prevent colon carcinogenesis.
Akita University College of Allied Medical Science, Japan.
T
T
Narisawa
Y
Y
Fukaura
M
M
Hasebe
M
M
Ito
R
R
Aizawa
M
M
Murakoshi
S
S
Uemura
F
F
Khachik
H
H
Nishino
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002338:Carotenoids / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D007413:Intestinal Mucosa / Q000187:drug effects*; D014975:Lutein / Q000494:pharmacology; D000077276:Lycopene; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control; D011230:Precancerous Conditions / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D019207:beta Carotene / Q000494:pharmacology
D016588:Anticarcinogenic Agents; D019207:beta Carotene; D002338:Carotenoids; C041635:alpha-carotene; D000077276:Lycopene; D014975:Lutein