Interleukin-6 receptor expression in the peripheral B cells of patients with multicentric Castleman's disease.
Interleukin-6 (IL-6) is an important regulator of terminal B-cell differentiation. Inappropriate oversynthesis of IL-6 may play primary role in the pathogenesis of multicentric Castleman's disease (MCD). We investigated the expression of the IL-6 receptor (IL-6R) in peripheral B cells from three patients with MCD, as well as the responsiveness of these cells to IL-6. Flow-cytometric analysis showed that IL-6R was significantly expressed on the peripheral B cells of two of three patients. The B cells expressing IL-6R spontaneously produced increased levels of immunoglobulin G (IgG). IL-6R-expressing B cells from one patient showed hyper-responsiveness to IL-6.
Department of Hematology, Showa University School of Medicine, Tokyo, Japan.
T
T
Ishiyama
M
M
Koike
S
S
Nakamura
T
T
Kakimoto
Y
Y
Akimoto
N
N
Tsuruoka
D000917:Antibody Formation; D015703:Antigens, CD / Q000378:metabolism*; D001402:B-Lymphocytes / Q000378:metabolism*; D005871:Castleman Disease / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D018123:Receptors, Interleukin / Q000378:metabolism*; D019947:Receptors, Interleukin-6
D015703:Antigens, CD; D007074:Immunoglobulin G; D018123:Receptors, Interleukin; D019947:Receptors, Interleukin-6