Genetic profiles of three inbred strains derived from wild rats (Rattus norvegicus) trapped in Japan.
In order to establish the genetic profiles of three inbred strains of rats (MITB/Yag, MITC/Yag and MITE/Yag; commonly designated as Mitake strains), which were derived from wild specimens of the Rattus norvegicus trapped in Mitake-cho, Gifu, Japan, 63 microsatellite markers were typed in these strains as well as nine other laboratory inbred strains. The data indicate that the MITB and MITC strains are very closely related (3% polymorphism between these strains), whereas the third strain MITE/Yag is relatively different from the other two strains (36% with the MITB, 39% with the MITC). Eighty-three to 58% of polymorphic loci had different alleles between the Mitake strains and the other strains, but 65-35% between the latter strains. In addition, 14 new alleles were found in the Mitake strains. These results suggest that the Mitake strains are useful for linkage analysis.
Institute of Laboratory Animals, Faculty of Medicine, Kyoto University, Japan.
Y
Y
Kondo
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K
Ohno
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S
Oda
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T
Serikawa
D000818:Animals; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics*; D007564:Japan; D018895:Microsatellite Repeats / Q000235:genetics; D011110:Polymorphism, Genetic; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics*
D005819:Genetic Markers