Incidence of radiation-induced insufficiency fractures of the female pelvis: evaluation with MR imaging.
OBJECTIVE
The purpose of this study was to assess the incidence, time of appearance, and evolution of radiation-induced insufficiency fractures of the female pelvis with MR imaging.


METHODS
Eighteen women (nine premenopausal and nine postmenopausal) with advanced cervical carcinoma were studied prospectively with MR imaging. The examinations totaled 216 and were scheduled before radiation therapy, three times during radiation therapy, and eight times after radiation therapy. T1-weighted and short inversion time inversion recovery images were obtained. The images were evaluated by two radiologists in consensus. The criterion for fracture was edema, indicated by an area of high signal intensity on short inversion time inversion recovery images and corresponding low signal intensity on T1-weighted images. CT scans (n = 61) and bone scans (n = 58) were used to confirm each diagnosis of fracture.


RESULTS
Sixteen (89%) of 18 patients (seven premenopausal and nine postmenopausal) showed findings compatible with insufficiency fractures. Thirteen patients had more than one lesion. The first fracture was detected between 3 and 12 months after the end of radiation therapy. During the study, the fractures associated with edema subsided without treatment in 41 (79%) of 52 lesions in 15 (94%) of 16 patients. Fractures were confirmed with additional imaging in all 16 patients (CT in 14 patients and bone scanning in nine patients).


CONCLUSIONS
Radiation-induced insufficiency fractures were frequently seen in premenopausal and postmenopausal women within 12 months after radiation therapy. Multiple fractures developed within 24 months. Twenty-one percent of the lesions healed during the observation period of 30 months.
Department of Radiology, the Norwegian Radium Hospital, Montebello, Oslo, Norway.
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Blomlie
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Rofstad
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Talle
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Sundfør
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Winderen
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Lien
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000532:radiotherapy; D004487:Edema / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D017102:Fracture Healing; D005598:Fractures, Spontaneous / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D015994:Incidence; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010384:Pelvic Bones / Q000000981:diagnostic imaging / Q000293:injuries* / Q000473:pathology / Q000528:radiation effects; D017698:Postmenopause; D017697:Premenopause; D011446:Prospective Studies; D011832:Radiation Injuries / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D011877:Radionuclide Imaging; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy / Q000009:adverse effects; D014057:Tomography, X-Ray Computed; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy