Hemostatic balance during the acute inflammatory reaction; with special reference to antithrombin III.
Inflammatory reaction caused by intramuscular injections of turpentine in 5 rabbits led to an obvious increase of not only plasma fibrinogen and factor VIII: C levels, but also of plasma antithrombin III activity, measured by a chromogenic assay as heparin cofactor. This activity rose from 80% +/- 10,8 (mean +/- SEM) before the injection to 123% +/- 6,56 48 hours later. Changes affecting plasma fibrinogen level and antithrombin II activity were much lesser in a group of 5 rabbits given small doses of intravenous endotoxin. It is considered that acute inflammation is accompanied by the setting of the hemostatic balance at a higher level.
Department of Physiopathology, University of Medicine and Pharmachy Cluj.
L A
LA
Pleşca
G
G
Bodizs
M
M
Cucuianu
D
D
Colhon
D000210:Acute-Phase Reaction / Q000139:chemically induced / Q000503:physiopathology*; D000818:Animals; D000990:Antithrombin III / Q000378:metabolism*; D001426:Bacterial Proteins / Q000494:pharmacology; D004926:Escherichia coli; D005169:Factor VIII / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006487:Hemostasis / Q000276:immunology*; D006801:Humans; D007201:Indicator Dilution Techniques; D008050:Lipid A; D010949:Plasma; D011817:Rabbits; D014425:Turpentine
D001426:Bacterial Proteins; D008050:Lipid A; D000990:Antithrombin III; D005169:Factor VIII; D005340:Fibrinogen; D014425:Turpentine