GDNF in a bind with known orphan: accessory implicated in new twist.
Lindsay
Ronald M
RM
Regeneron Pharmaceuticals, Incorporated, Tarrytown, New York 10591, USA.
Yancopoulos
George D
GD
D000818:Animals; D029721:Drosophila Proteins; D051100:Glial Cell Line-Derived Neurotrophic Factor; D051097:Glial Cell Line-Derived Neurotrophic Factor Receptors; D006801:Humans; D008961:Models, Structural; D009414:Nerve Growth Factors / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology* / Q000627:therapeutic use; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D018696:Neuroprotective Agents / Q000378:metabolism* / Q000627:therapeutic use; D010300:Parkinson Disease / Q000628:therapy; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000502:physiology*; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases / Q000737:chemistry / Q000502:physiology*; D018121:Receptors, Cytokine / Q000737:chemistry / Q000502:physiology
D029721:Drosophila Proteins; C495039:GDNF protein, human; D051100:Glial Cell Line-Derived Neurotrophic Factor; D051097:Glial Cell Line-Derived Neurotrophic Factor Receptors; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D018696:Neuroprotective Agents; D011518:Proto-Oncogene Proteins; D018121:Receptors, Cytokine; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases; C416649:Ret protein, Drosophila