The influence of age on the thermal transition of serum albumine in rats.
Serum albumine from rats at different ages (1, 3, 9, 18 months) undergoes a thermal reversible denaturation in the range of 40-53 degrees C. Thermal transitions of unbuffered solution of native protein show a significant change of pH as they became heat denaturated. The protein molecule has been analysed in melting studies, manifested by cooperative dissociation of protons and it experiences a decrease in temperature transition with the younger the rats.
D. Danielopolu Institute of Normal and Pathological Physiology, Bucharest, Romania.
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D000375:Aging / Q000097:blood*; D000818:Animals; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D008297:Male; D011489:Protein Denaturation / Q000502:physiology; D051381:Rats; D012709:Serum Albumin / Q000737:chemistry* / Q000502:physiology*
D012709:Serum Albumin