Change in optic disk topography after trabeculectomy.
OBJECTIVE
To investigate the relationship between optic disk topography and intraocular pressure before and after trabeculectomy with confocal scanning laser ophthalmoscopy.


METHODS
The eyes of 49 consecutive patients undergoing trabeculectomy at a university-based glaucoma practice underwent preoperative and postoperative imaging using a confocal scanning laser ophthalmoscope (Heidelberg Retina Tomograph). Three images of one eye of each patient were obtained with a 15-degree field of view. Preoperative images were obtained approximately 2 months before surgery (mean +/- SD, 2.4 +/- 1.6 months). Postoperative images were obtained at least 3 months after surgery (mean, 4.5 +/- 2.6 months).


RESULTS
Mean preoperative intraocular pressure, postoperative intraocular pressure, and percent change in intraocular pressure respectively were 23.1 +/- 6.8 mm Hg, 12.7 +/- 7.1 mm Hg, and 43.8% +/- 29.9%. A significant association (P < .01) was found between percent decrease in intraocular pressure and decreases in cup area, cup volume, and cup/disk area ratio as well as between percent decrease in intraocular pressure and increases in rim area, rim volume, mean height contour, retinal cross-section area, and height in contour. Between 11.7% and 31.2% of the variability (R2) in these parameters was explained by the percent change in intraocular pressure. Topography changes were more strongly associated with percent change than with mean change in intraocular pressure. We found no association between percent decrease in intraocular pressure and reference plane height or maximum cup depth.


CONCLUSIONS
Changes in optic nerve topography were associated with reduction in intraocular pressure after trabeculectomy.
Glaucoma Center and Research Laboratories, University of California, San Diego 92093-0946, USA.
I
I
Irak
L
L
Zangwill
V
V
Garden
S
S
Shakiba
R N
RN
Weinreb
D000046:Academic Medical Centers; D000368:Aged; D005901:Glaucoma / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D007834:Lasers; D019721:Ophthalmoscopes; D009898:Optic Disk / Q000473:pathology*; D009900:Optic Nerve / Q000473:pathology; D012160:Retina / Q000473:pathology; D014130:Trabeculectomy