Bleb rupture following filtering surgery with mitomycin-C: clinicopathologic correlations.
A 91-year-old woman with a complete rupture of her mitomycin-C filtration bleb associated with eye rubbing while crying was examined. An 18mm soft contact lens was placed preoperatively to re-form the anterior chamber and the patient underwent a conjunctival advancement. Histopathology of the free conjunctival specimen revealed a stratified squamous epithelium with marked attentuation of the subepithelial tissue in the area treated with mitomycin-C. Bleb rupture may be associated with minimal physical trauma following guarded filtration surgery. Successful visual rehabilitation is possible with conjunctival advancement, yet long-term survival of the bleb is poor.
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, School of Medicine, FL 33101-6880, USA.
D S
DS
Greenfield
R K
RK
Parrish
D000368:Aged; D000369:Aged, 80 and over; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003228:Conjunctiva / Q000293:injuries* / Q000473:pathology; D005260:Female; D018463:Filtering Surgery; D005901:Glaucoma / Q000628:therapy*; D006801:Humans; D008405:Massage / Q000009:adverse effects*; D016685:Mitomycin / Q000627:therapeutic use*; D012421:Rupture; D013529:Surgical Wound Dehiscence / Q000209:etiology / Q000473:pathology* / Q000628:therapy
D000903:Antibiotics, Antineoplastic; D016685:Mitomycin