Omega-conotoxin-MVIID blocks an omega-conotoxin-GVIA-sensitive, high-threshold Ca2+ current in fish retinal ganglion cells.
Reduction of Ca2+ current amplitude by the Conus peptide omega-conotoxin-MVIID (omega-CTx-MVIID) was measured in voltage-clamped, goldfish retinal ganglion cells. Effects of depolarizing shifts in holding potential, and sequential applications of omega-CTx-MVIID, omega-CTx-GVIA, and BAY-K-8644, together with effects of Ni2+ and omega-Aga-IIIA, indicated that omega-CTx-MVIID may target Ca2+ channels differing from those termed T, L, N, P < Q and R.
Tabata
T
T
Section of Neurobiology, Physiology, and Behavior, University of California, Davis 95616, USA.
Olivera
B M
BM
Ishida
A T
AT
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects*; D020916:Conotoxins; D005399:Fishes; D008564:Membrane Potentials / Q000187:drug effects*; D018408:Patch-Clamp Techniques; D010455:Peptides / Q000494:pharmacology*; D012165:Retinal Ganglion Cells / Q000187:drug effects*; D020866:omega-Conotoxin GVIA
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D020916:Conotoxins; D010455:Peptides; C085882:omega-conotoxin MVIID; D020866:omega-Conotoxin GVIA