Long bone fracture healing: IGF-I concentrations and specific binding to erythrocytes.
Animal experiments suggested a possible interaction between GH or GH-dependent growth factors and bone healing. The aim of this study was to determine whether there were any significant changes in serum levels of IGF-I and/ or the activity of its receptors while a fractured bone was healing. Serum concentrations of IGF-I and its specific binding to erythrocyte receptors (IGF-I SB) were determined in a group of 12 prepubertal children treated for long bone fractures. Results were compared to those obtained from a group of age- and sex-matched controls. Blood samples were taken from all patients two weeks following the fractures, when bone formation rate should have been maximal. We found no difference in IGF-I SB between the two groups. However, serum IGF-I levels were increased in the group of children with fractures compared to controls. Results are suggestive of a possible interaction between IGF-I and bone repair processes as other investigators have suggested on the basis of animal experiments.
First Department of Pediatrics, P. & A. Kyriakou Children's Hospital, Athens, Greece.
F H
FH
Karachaliou
L
L
Stamogiannou
K
K
Maravelias
C S
CS
Bartsocas
A
A
Koutselinis
D001842:Bone and Bones / Q000293:injuries*; D002648:Child; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D017102:Fracture Healing / Q000502:physiology*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D017526:Receptor, IGF Type 1 / Q000097:blood
D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1