The neutron sensitivity of dosimeters applied to boron neutron capture therapy.
To obtain a high accuracy in the dosimetry of an epithermal neutron beam used for boron neutron capture therapy (BNCT), the neutron sensitivity of dosimeters applied to determine the various dose components in-phantom has been investigated. The thermal neutron sensitivity of Mg(Ar) ionization chambers, TE(TE) ionization chambers, and thermoluminescent dosimeters (TLD) has been experimentally determined in a "pure" thermal neutron beam. Values much higher than theoretically expected were obtained and a variation up to a factor of 2.5 was found between values for the thermal neutron sensitivity of different Mg(Ar) ionization chambers of the same type. The sensitivity of the TE(TE) ionization chamber to intermediate and fast neutrons (kt) has been calculated for the neutron energy spectrum in a phantom irradiated by a clinical epithermal BNCT beam, obtained using Monte Carlo simulations. The kt value for muscle tissue ranged from 0.87 at small depths to 0.93 at larger depths in the phantom. The application of the thermal neutron sensitivities to measurements in a phantom irradiated by the epithermal BNCT beam yielded up to 17% higher gamma-ray dose rate values compared with measurements using 6Li containing caps to shield the detectors from thermal neutrons, due to a substantial perturbation of the in-phantom radiation field by the 6Li cap. The application of the new kt values resulted in a dose from intermediate and fast neutrons about 10% higher than the dose based on currently applied relative neutron sensitivities of TE(TE) chambers in BNCT beams. The resulting improvement in the accuracy of the determination of the dose from gamma rays and intermediate and fast neutrons is important in view of the required accuracy for dosimetry in radiotherapy.
The Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Amsterdam, The Netherlands.
C P
CP
Raaijmakers
P R
PR
Watkins
E L
EL
Nottelman
H W
HW
Verhagen
J T
JT
Jansen
J
J
Zoetelief
B J
BJ
Mijnheer
D055592:Biophysical Phenomena; D001703:Biophysics; D016754:Boron Neutron Capture Therapy; D005214:Fast Neutrons; D005720:Gamma Rays; D006801:Humans; D009010:Monte Carlo Method; D009502:Neutrons; D019047:Phantoms, Imaging; D011874:Radiometry / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D011880:Radiotherapy Planning, Computer-Assisted; D013819:Thermoluminescent Dosimetry