Tubal sterilization by means of selective catheterization: comparison of a hydrogel and a collagen glue.
OBJECTIVE
To test, in an animal model, two potentially suitable materials for nonsurgical selective tubal sterilization.


METHODS
A hydrogel that forms an in situ plug by phase inversion of a polymer solution was placed in four rabbit fallopian tubes, and a proprietary collagen glue was placed into three rabbit fallopian tubes by means of transvaginal fluoroscopic fallopian tube catheterization. As controls, 11 tubes were catheterized without sterilization material injection. The rabbits were bred, and the presence of embryos was confirmed with palpation and at autopsy. Histologic analysis was performed.


RESULTS
The short-term contraception rate was 100% in the hydrogel group, 33% in the collagen glue group, and 0% in the control group (P < .001 hydrogel group, P not significant in collagen group). Inflammation was minimal in the three groups (P not significant).


CONCLUSIONS
The collagen glue had an insufficient contraceptive effect and should be abandoned. The hydrogel used proved effective and biocompatible, and long-term studies of this compound are warranted.
Maubon
A J
AJ
Department of Radiology, Centre Medico-chirurgical Beausoleil, Montpellier, France.
Thurmond
A S
AS
Laurent
A
A
Machan
L S
LS
Scanlan
R M
RM
Nikolchev
J
J
Rouanet
J P
JP
D000181:Acrylonitrile / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D001344:Autopsy; D001672:Biocompatible Materials / Q000737:chemistry; D001947:Breeding; D002404:Catheterization / Q000379:methods*; D003094:Collagen / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003267:Contraception; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004622:Embryo, Mammalian; D005187:Fallopian Tubes / Q000033:anatomy & histology / Q000187:drug effects; D005260:Female; D005471:Fluoroscopy; D010173:Palpation; D011817:Rabbits; D015641:Radiography, Interventional; D012488:Salpingitis / Q000139:chemically induced; D013246:Sterilization, Tubal / Q000379:methods*; D014014:Tissue Adhesives / Q000009:adverse effects / Q000627:therapeutic use*
D001672:Biocompatible Materials; D014014:Tissue Adhesives; D003094:Collagen; D000181:Acrylonitrile; D004121:Dimethyl Sulfoxide