Modern developments in molecular replacement.
Molecular replacement is a possible route to obtaining initial phasing for an unknown structure from a known, structurally related molecule. Recent years have seen an explosive growth in the number of protein structures solved using this technique. Automated packages can make the application quite straightforward. Progress has been made in the placing of fragments of complexes, and in the use of imprecise models from NMR or homology modelling. Such models have necessitated the development of new approaches to rebuilding and refinement.
Chemistry Department, University of York, Heslington, UK. j.turkenburg@yorvic.york.ac.uk
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JP
Turkenburg
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Dodson
D000818:Animals; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D011506:Proteins / Q000737:chemistry*
D011506:Proteins