Importance of the carboxy-terminus of human interleukin-11 in conserving its biological activity.
Biological activities of the carboxy-terminal (C-terminal) deletion mutants of human interleukin-11 (IL-11) were analyzed. Removal of only 1 amino-acid residue (leucine) from the C-terminus caused nearly an 80% loss of its biological activity. This shows the importance of C-terminus of human IL-11 in terms of conserving the biological activity.
Biomedical Research Laboratories, Sankyo Co. Ltd., Tokyo, Japan.
K
K
Miyadai
J
J
Ohsumi
C
C
Yoshimura
I
I
Kawashima
Y
Y
Ito
D000595:Amino Acid Sequence; D001483:Base Sequence; D001665:Binding Sites; D006801:Humans; D017370:Interleukin-11 / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D008969:Molecular Sequence Data; D009154:Mutation; D013329:Structure-Activity Relationship
D017370:Interleukin-11