Effect of long-term administration of stobadine to rats on selective variables of spontaneous behaviour of their offspring.
The present study investigated the effect of long-term administration of the cardioprotective drug stobadine (STB) to dams on selective variables of spontaneous behaviour of their offspring in open field (horizontal and vertical activities, frequency and duration of grooming, and duration of total activity and immobility) tested on day 60 of age. The treatment of dams with STB significantly increased horizontal activity of offspring in both sexes. The other variables studied were not affected, with the exception of a significant increase in the frequency and duration of grooming and in the duration of total activity in females compared to males from STB treated dams.
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovakia.
M
M
Dubovický
P
P
Kovacovský
I
I
Rychlík
E
E
Ujházy
A
A
Gajdosík
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002243:Carbolines / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D005260:Female; D006120:Grooming / Q000187:drug effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D002243:Carbolines; C100106:dicarbine