The efficacy and pharmacokinetics of long-term low-level intraruminal administration of triclabendazole in buffalo with induced fasciolosis.
A study was conducted on the pharmacokinetics and therapeutic efficacy of triclabendazole at three low dose rates of 0.5, 1.0 and 1.5 mg/kg body weight in buffaloes experimentally infected with Fasciola gigantica. The pharmacokinetics were compared with the effects of a single intraruminal dose at 24.0 mg/kg body weight in uninfected buffaloes. At all three dose rates, an equilibrium between the absorption of triclabendazole and the disposition of its metabolites was observed by days 3 and 4 and remained almost unchanged thereafter. Continuous daily dosing at 1.5 mg/kg body weight proved to be efficacious against liver fluke infection in buffaloes.
Biotechnology Laboratory, National Dairy Development Board, Gujarat, India.
P K
PK
Sanyal
S C
SC
Gupta
D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D001711:Biotransformation; D002020:Buffaloes; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005211:Fascioliasis / Q000188:drug therapy*; D007267:Injections; D008297:Male; D008657:Metabolic Clearance Rate; D012417:Rumen; D000077682:Triclabendazole
D000871:Anthelmintics; D001562:Benzimidazoles; D000077682:Triclabendazole