Growth hormone potentiates the in vivo biological activities of endotoxin in the rat.
To investigate if growth hormone (GH) alters the effects of endotoxin in rats, endotoxin (5 mg kg-1 body weight) was injected into normal rats and into rats primed with GH for 3 days. Endotoxin had injurious effects on renal and liver function and induced hypoglycaemia and hyperlipidaemia as expected. GH-primed rats became extremely sick after endotoxin challenge and had more marked abnormalities of renal and liver function and much more pronounced hypoglycaemia and hyperlipidaemia than non-primed rats. It is concluded that growth hormone potentiates the in vivo biological activities of endotoxin in the rat. The results may also suggest that caution should be exerted when considering GH treatment in catabolic situations with endotoxaemia and that special attention should be paid to the prevention of infection during GH therapy in such situations.
Metabolism Unit, Department of Medicine, Karolinska Institute at Huddinge University Hospital, Sweden.
W
W
Liao
M
M
Rudling
B
B
Angelin
D000818:Animals; D002784:Cholesterol / Q000097:blood; D004357:Drug Synergism; D004731:Endotoxins / Q000633:toxicity*; D013006:Growth Hormone / Q000494:pharmacology*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013045:Species Specificity
D004731:Endotoxins; D008074:Lipoproteins; D013006:Growth Hormone; D002784:Cholesterol