Secretion of extracellular proteins by enterohemorrhagic Escherichia coli via a putative type III secretion system.
Enterohemorrhagic and enteropathogenic Escherichia coli (EHEC and EPEC) infections result in attaching and effacing lesions on intestinal epithelial cells. Secretion of extracellular proteins via a type III secretion apparatus is necessary for the formation of attaching and effacing lesions by EPEC. We now show that EHEC also secretes polypeptides via a putative type III secretion system. The secreted EHEC proteins are recognized by rabbit antiserum raised against the proteins secreted from EPEC and by human serum from a patient infected with an EHEC O157:H7 strain.
Jarvis
K G
KG
Center for Vaccine Development, Department of Medicine, University of Maryland, Baltimore 21201, USA.
Kaper
J B
JB
D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000502:physiology; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000276:immunology / Q000382:microbiology; D019453:Escherichia coli O157 / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity*; D029968:Escherichia coli Proteins; D006463:Hemolytic-Uremic Syndrome / Q000276:immunology; D006801:Humans; D008970:Molecular Weight; D016254:Mutagenesis, Insertional; D011817:Rabbits; D014774:Virulence
D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; C087863:EaeB protein, E coli; D029968:Escherichia coli Proteins; C102051:EspA protein, E coli; C095177:SepB protein, E coli