[Essential hypertension].
Abnormal membrane sodium transport system is a hypothesis that might explain the mechanism of pathophysiology of essential hypertension. Increased intracellular sodium concentration, which is induced by altered function in either Na+ -K+ pump, Na+ -K+ cotransport, Na+ -Li+ countertransport, or Na+ -H+ antiport, may increased intracellular calcium ion and cause vasoconstriction. Increased intracellular pH by enhanced Na+ -H+ antiport may also play an important role of increment of vascular tone in hypertension.
Ando
K
K
Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan.
Fujita
T
T
D000818:Animals; D001794:Blood Pressure; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D017136:Ion Transport; D012964:Sodium / Q000378:metabolism*; D017923:Sodium-Hydrogen Exchangers; D000254:Sodium-Potassium-Exchanging ATPase
D017923:Sodium-Hydrogen Exchangers; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase