Pesticide and model drug release from carboxymethylceullose microspheres.
Water soluble derivatives of cellulose are widely used in various biomedical and biotechnological applications. Sodium carboxymethyl cellulose was insolubilized in the form of microspheres using aluminium chloride as the crosslinking agent. It was observed that, depending on the preparation medium pH, the spherical product could either be a microsphere with an ionotropic interior or a microcapsule. Various microspheres with different crosslinker, biopolymer, and drug (2',7'-dichlorofluorescein and aldicarb) contents were prepared and their structures, properties, swelling behaviour and release kinetics investigated. The release kinetics could not be described by typical Fickian or non-Fickian approaches.
Middle East Technical University, Department of Biological Sciences, Biotechnology Research Unit, Ankara, Turkey.
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R
Darvari
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V
Hasirci
D000448:Aldicarb / Q000378:metabolism / Q000494:pharmacology; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000494:pharmacology; D002266:Carboxymethylcellulose Sodium / Q000378:metabolism*; D002712:Chlorides / Q000494:pharmacology; D003270:Contraceptive Agents / Q000737:chemistry / Q000378:metabolism; D003432:Cross-Linking Reagents / Q000378:metabolism; D004339:Drug Compounding; D005452:Fluoresceins / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008853:Microscopy; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010575:Pesticides / Q000378:metabolism*; D013055:Spectrophotometry, Infrared
D017607:Aluminum Compounds; D002712:Chlorides; D003270:Contraceptive Agents; D003432:Cross-Linking Reagents; D005452:Fluoresceins; D010575:Pesticides; D000077410:Aluminum Chloride; D000448:Aldicarb; D002266:Carboxymethylcellulose Sodium