Attenuation by nicotinamide of the streptozocin induced early hyperglycaemia in fasting rats.
The effect of nicotinamide on the streptozocin induced early hyperglycaemia in 48-hour fasted rats was investigated. It was shown that 240 or 400 mg/kg nicotinamide significantly attenuated the streptozocin induced early hyperglycaemia. Nicotinamide should be administered no later than 1 hour after the streptozocin administration. Lower level doses of nicotinamide such as 80 mg/kg were unable to attenuate the streptozocin induced early hyperglycaemia. The possibility of nicotinamide offsetting the streptozocin effect was discussed.
Wong
K K
KK
Department of Pharmacology, National Yang Ming University Taipei, Taiwan, Republic of China.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D005215:Fasting; D006943:Hyperglycemia / Q000139:chemically induced* / Q000188:drug therapy / Q000517:prevention & control*; D008297:Male; D009536:Niacinamide / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin / Q000633:toxicity*
D000903:Antibiotics, Antineoplastic; D009536:Niacinamide; D013311:Streptozocin