Future research needs for non-cancer and cancer effects among populations exposed to 1,3-butadiene.
In the last decade there has been in-depth research into understanding the health effects of 1,3-butadiene in humans and in animals. With increasing knowledge of metabolism, pharmacokinetics and mechanism of action studied in animals, the uncertainties in risk assessment will be lessened. Still, some data gaps exist which, if filled, will be useful for meaningful risk assessments for the general population. This paper discusses the future needs for research in both non-cancer and cancer effects.
Koppikar
A M
AM
U.S. EPA, National Center for Environmental Assessment, Washington, DC 20460, USA.
D002070:Butadienes / Q000493:pharmacokinetics / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D018736:DNA Adducts / Q000378:metabolism; D004784:Environmental Monitoring; D006801:Humans; D009153:Mutagens / Q000633:toxicity*; D018570:Risk Assessment
D002070:Butadienes; D002273:Carcinogens; D018736:DNA Adducts; D009153:Mutagens; C031763:1,3-butadiene