[Foveal cone densitometry in high myopia].
We performed foveal cone densitometry using a modified fundus camera in 17 eyes of 17 normal subjects (age range, 20 to 47 yr, refractive error, +2.0 to -2.5 D) and 15 eyes of 15 high myopia subjects with normal visual acuity (age range, 18 to 46 yr, refractive error, -9.0 to -14.5 D). After fully bleaching, the density of photopigment was measured for 7 minutes by a test spot of 562 nm in wavelength and 1 degree in diameter, focussed on the fovea. Two-way density and the time constant of pigment regeneration were calculated. No significant difference was found in two-way density between the two groups. The time constant in high myopia (161.6 +/- 36.6 sec), however, was significantly increased (p < 0.01), compared with normals (124.0 +/- 28.7 sec). To study the correlation of psychophysical visual function, we performed a photostress recovery test, which revealed a significant delay of the recovery time in high myopia (p < 0.01). These results suggest that a delay in foveal cone pigment kinetics precedes loss of cone cells or chorioretinal degeneration in high myopia.
Horio
N
N
Department of Ophthalmology, Nagoya University School of Medicine, Aichi, Japan.
Miyake
Y
Y
Horiguchi
M
M
D000293:Adolescent; D000328:Adult; D003720:Densitometry; D005260:Female; D005584:Fovea Centralis / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000378:metabolism*; D017949:Retinal Cone Photoreceptor Cells / Q000378:metabolism*; D012168:Retinal Pigments / Q000378:metabolism
D012168:Retinal Pigments