Chronic nicotine treatment delays the developmental increase in brain muscarinic receptors in rat neonate.
Developmental increase in the muscarinic receptors ([3H]quinuclidinyl benzylate binding sites) of rat neonate brain (cerebral cortex and cerebellum) was significantly inhibited by chronic nicotine treatment of the dams during pregnancy and lactation. However, development of the nicotinic receptors ([3H]cytisine binding sites) was not inhibited and rather was up-regulated in the cerebral cortex and brainstem by the nicotine treatment. Such inhibition and up-regulation were not seen in nicotine-withdrawn rats after birth. These results suggest that nicotine treatment during lactation may cause a remarkable delay in development of muscarinic neurotransmission in rat neonates.
Department of Pharmacology, Fukui Medical School, Japan.
J
J
Zhu
M
M
Takita
Y
Y
Konishi
M
M
Sudo
I
I
Muramatsu
D000375:Aging / Q000378:metabolism*; D000470:Alkaloids / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001392:Azocines; D001921:Brain / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D001933:Brain Stem / Q000378:metabolism; D002531:Cerebellum / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects*; D006624:Hippocampus / Q000378:metabolism; D007774:Lactation; D008431:Maternal-Fetal Exchange; D008636:Mesencephalon / Q000378:metabolism; D009538:Nicotine / Q000494:pharmacology*; D009928:Organ Specificity; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011807:Quinolizines; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011976:Receptors, Muscarinic / Q000096:biosynthesis*; D015854:Up-Regulation; D000093843:Quinolizidine Alkaloids
D000470:Alkaloids; D001392:Azocines; D009538:Nicotine; D011807:Quinolizines; D011813:Quinuclidinyl Benzilate; D011976:Receptors, Muscarinic; C004712:cytisine; D000093843:Quinolizidine Alkaloids