Patency and tissue response related to two types of polytetrafluoroethylene-covered stents in the dog.
OBJECTIVE
A canine model was used to determine tissue response related to placement of two different designs of polytetrafluoroethylene (PTFE) covered stents in the peripheral vascular system.


METHODS
Two types of PTFE covered stents were implanted in the iliac arteries of 15 mongrel dogs. The tissue response within and beneath these endoprostheses was studied and compared to that for control Palmaz stents with angiographic and histologic examination at 1, 3, and 6 months.


RESULTS
The bare Palmaz stent endothelialized faster and with a thinner neointima than either covered stent design. Neointima formation proceeds from the ends toward the center of PTFE-covered stents regardless of design, with minimal transgraft tissue penetration. However, the pattern of neointimal response differed for the two designs and suggests that early thrombus formation at the stent-graft interface promotes neointimal development.


CONCLUSIONS
The bare Palmaz stent showed the least amount of luminal encroachment at all time points compared with either covered stent. Regarding the covered stents, the different patterns of tissue response with the covered stents may provide insight into the design of stent-grafts for human use.
Department of Radiology, Cleveland Clinic Foundation, OH 44195, USA.
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D000818:Animals; D002406:Catheterization, Peripheral / Q000295:instrumentation; D004195:Disease Models, Animal; D004285:Dogs; D004730:Endothelium, Vascular / Q000473:pathology / Q000503:physiopathology; D004867:Equipment Design; D005500:Follow-Up Studies; D006801:Humans; D007083:Iliac Artery / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D011138:Polytetrafluoroethylene; D011859:Radiography; D015607:Stents; D013499:Surface Properties; D013536:Suture Techniques; D013927:Thrombosis / Q000473:pathology; D017539:Tunica Intima / Q000473:pathology / Q000503:physiopathology; D014654:Vascular Patency
D011138:Polytetrafluoroethylene