Prenatal diagnosis of ectrodactyly: the 'lobster claw' anomaly.
Ectrodactyly is a rare condition characterized by absence of digits, ranging from single absence of a finger to the split hand/foot deformity. This anomaly has been reported as sporadic and in association with a number of genetic and non-genetic syndromes, such as the autosomal dominant ectrodactyly and the ectrodactyly-ectodermal dysplasia-cleft palate (EEC) syndromes. In this report we present two cases of ectrodactyly prenatally diagnosed by ultrasonography during the second trimester of pregnancy. Routine examination of fetal hands and feet during second-trimester ultrasonography should make the detection of hand and foot malformations more frequent.
Centre for Fetal Care, Royal Postgraduate Medical School, Institute of Obstetrics and Gynaecology, Queen Charlotte's and Chelsea Hospital, London, UK.
K Y
KY
Leung
N A
NA
MacLachlan
W
W
Sepulveda
D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging / Q000473:pathology*; D000032:Abortion, Therapeutic; D000328:Adult; D000649:Amniocentesis; D005260:Female; D005385:Fingers / Q000002:abnormalities*; D006228:Hand Deformities, Congenital / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D011272:Pregnancy, Multiple; D014427:Twins; D016216:Ultrasonography, Prenatal