Matrilysin is associated with progression of colorectal tumor.
Matrilysin and gelatinase A, B mRNA expressions were examined in colorectal tumors. Matrilysin mRNA was observed exclusively in tumors, while the others were also found in normal mucosa surrounding tumors. Further analysis revealed that colorectal adenomas with severe dysplasia, not with mild dysplasia, expressed matrilysin with lower levels than cancers. The level of matrilysin mRNA expression increased with the advancement of stages of colorectal cancers, consequently a relatively higher expression was observed in liver metastatic tumors than primary tumors. These results suggest that matrilysin mRNA expression was correlated with the progression of colorectal tumors, and this enzyme may also play a role in developing metastatic tumors in liver.
Ishikawa
T
T
Department of Surgery, Yokohama City University, School of Medicine, Kanagawa, Japan.
Ichikawa
Y
Y
Mitsuhashi
M
M
Momiyama
N
N
Chishima
T
T
Tanaka
K
K
Yamaoka
H
H
Miyazakic
K
K
Nagashima
Y
Y
Akitaya
T
T
Shimada
H
H
D000236:Adenoma / Q000201:enzymology / Q000235:genetics; D014408:Biomarkers, Tumor / Q000032:analysis*; D017364:Collagenases / Q000032:analysis; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000473:pathology; D018450:Disease Progression; D018093:Gelatinases / Q000032:analysis; D006801:Humans; D008113:Liver Neoplasms / Q000201:enzymology* / Q000556:secondary*; D020778:Matrix Metalloproteinase 2; D020783:Matrix Metalloproteinase 7; D020780:Matrix Metalloproteinase 9; D008666:Metalloendopeptidases / Q000032:analysis* / Q000235:genetics; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis
D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D017364:Collagenases; D018093:Gelatinases; D008666:Metalloendopeptidases; D020783:Matrix Metalloproteinase 7; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9