Influence of Ukrain on DNA, RNA and protein synthesis in malignant cells.
3H labelled thymidine, uridine and leucine were used to evaluate the synthesis of DNA, RNA and proteins in malignant cells and normal cells incubated with Ukrain in different concentrations. Compared with the controls, the inhibiting effects of Ukrain are demonstrated in guinea pig hepatocytes, CIL hepatocytes, human tonsil cells, two murine lymphomas, murine myeloma, Yoshida cells, two HeLa strains, EsB- and EB- (murine) lymphomas. YAC-1, P815 and human WiDr cells. Ukrain inhibits the DNA, RNA and protein synthesis in malignant cell lines at relatively high concentrations and to a small extent in normal cells.
Ukrainian Anti-Cancer Institute, Vienna, Austria.
J W
JW
Nowicky
W
W
Hiesmayr
W
W
Nowicky
A
A
Liepins
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001600:Berberine Alkaloids; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D006168:Guinea Pigs; D006367:HeLa Cells; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008223:Lymphoma / Q000188:drug therapy / Q000378:metabolism; D051379:Mice; D009101:Multiple Myeloma / Q000188:drug therapy / Q000378:metabolism; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism*; D014066:Palatine Tonsil / Q000187:drug effects / Q000378:metabolism; D010617:Phenanthridines; D012334:RNA, Neoplasm / Q000096:biosynthesis*; D012517:Sarcoma, Yoshida / Q000188:drug therapy / Q000378:metabolism
D000470:Alkaloids; D000970:Antineoplastic Agents; D001600:Berberine Alkaloids; D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D010617:Phenanthridines; D012334:RNA, Neoplasm; C060921:ukrain