Corneal coloboma, aphakia and retinal neovascularization with anterior segment dysgenesis (Peters' anomaly).
An infant with bilateral Peters' Anomaly, with corneal opacification in the right eye and an opacification with an axial defect in the left also had an associated hydrocephalus and cardiac anomalies that proved fatal; histopathology of the right eye showed retinal neovascularization in addition to findings consistent with a diagnosis of Peters' Anomaly; in the left eye, pathologic findings were suggestive of a corneal coloboma associated with aphakia.
Department of Ophthalmology, School of Medicine, University of North Carolina, Chapel Hill 27599-7040, USA.
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CA
Gunderson
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R
Stone
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R
Peiffer
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Freedman
D000015:Abnormalities, Multiple / Q000235:genetics* / Q000473:pathology; D000869:Anterior Eye Segment / Q000002:abnormalities* / Q000473:pathology; D001035:Aphakia / Q000151:congenital* / Q000473:pathology; D003103:Coloboma / Q000235:genetics* / Q000473:pathology; D003315:Cornea / Q000002:abnormalities* / Q000473:pathology; D003318:Corneal Opacity / Q000151:congenital* / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D015861:Retinal Neovascularization / Q000151:congenital* / Q000473:pathology