In vitro activities of azithromycin, clarithromycin, and other antibiotics against Chlamydia pneumoniae.
The in vitro susceptibilities of Chlamydia pneumoniae isolates to macrolide, tetracycline, and quinolone antibiotics were determined. Tetracycline, clarithromycin, and erythromycin had the lowest MICs in the first cell culture passage. Azithromycin required the lowest concentration for complete inhibition of inclusion formation on the second pass into antibiotic-free medium, likely reflecting its high intracellular concentrations.
Department of Pathobiology, University of Washington, Seattle 98195, USA.
C C
CC
Kuo
L A
LA
Jackson
A
A
Lee
J T
JT
Grayston
D042462:4-Quinolones; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology; D017963:Azithromycin / Q000494:pharmacology*; D016993:Chlamydophila pneumoniae / Q000187:drug effects*; D017291:Clarithromycin / Q000627:therapeutic use*; D008826:Microbial Sensitivity Tests; D013754:Tetracyclines / Q000494:pharmacology
D042462:4-Quinolones; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D013754:Tetracyclines; D017963:Azithromycin; D017291:Clarithromycin