Hypertonic-hyperoncotic solution increases canine lymph flows.
BACKGROUND
Hypertonic-hyperoncotic solutions (HHS) have attracted a lot of interest in the treatment of various forms of hypovolaemic conditions during the last decade. It has been speculated that HHS might even be of therapeutic value in normo- and hypervolaemic conditions by mobilising extravascular fluid.


METHODS
We studied thoracic and abdominal lymphatic flows and circulatory response following the administration of a single bolus injection of hypertonic-hyperoncotic solution, 10% dextran 60 in 7.2% saline (HHS), in a nonhypovolaemic canine model. A modified surgical procedure for collecting thoracic lymph is also presented.


RESULTS
Both thoracic and abdominal lymph flow increased significantly by approximately 50% after administration of HHS. Cardiac output and calculated pulmonary capillary hydrostatic pressure increased.


CONCLUSIONS
Hypertonic-hyperoncotic solution given intravenously as a single injection increased both thoracic and abdominal lymph flows in the initially normovolaemic animal.
Wickerts
C J
CJ
Department of Anaesthesia and Intensive Care, Karolinska Institute, Danderyd Hospital, Sweden.
Berg
B
B
Blomqvist
H
H
D000818:Animals; D004285:Dogs; D005260:Female; D006982:Hypertonic Solutions / Q000494:pharmacology*; D008196:Lymph / Q000502:physiology*; D008297:Male
D006982:Hypertonic Solutions