Immunohistochemical study of epithelioid hemangioendothelioma in the leg: a case report.
Epithelioid hemangioendothelioma is a relatively rare lesion. Although its histogenesis has been well described, its immunohistochemical characteristics remain controversial. A case of epithelioid hemangioendothelioma of the soft tissue of the right leg in a 67-year-old Chinese woman is reported. Histologic findings of intracytoplasmic lumina in the tumor cells and positive immunostaining for vimentin, factor VIII-related antigen. CD34 and Ulex europaeus agglutinin 1 (UEA-1) were obtained, demonstrating differentiation of the tumor cells to endothelial cells, although staining for antibodies to cytokeratins AE1/AE3 and CAM5.2 was weak. CD34 as well as Factor VIII-related antigen is a useful marker of endothelial differentiation in this tumor. A review of the literature is also presented.
Department of Pathology, Kochi Medical School, Japan.
S
S
Liang
Y
Y
Ohtsuki
J
J
Iwata
M
M
Furihata
E
E
Ido
H
H
Sonobe
D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D018323:Hemangioendothelioma, Epithelioid / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007866:Leg; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000473:pathology; D014746:Vimentin / Q000032:analysis
D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D014746:Vimentin