Pharmacological preconditioning of ischemic heart disease by low-dose dipyridamole.
Fourteen patients affected with coronary artery disease underwent two consecutive dipyridamole echocardiographic stress tests, in basal conditions and after repeated low doses of intravenous dipyridamole, following the observation that pulse increases in adenosine plasma levels due to repeated intravenous administration of dipyridamole mimic the mechanism of ischemic preconditioning. Echocardiographic, electrocardiographic, haemodynamic parameters, and adenosine plasma levels were measured. After the second test, six patients were completely negative, and in those eight still positive the onset of dyssynergy was delayed.
Institute of Clinical Medicine, University of Siena School of Medicine, Policlinico Le Scotte, Italy.
F L
FL
Pasini
F
F
Guideri
D
D
Ferber
G
G
Galgano
A
A
Bianchi
S
S
Isidori
L
L
De Giorgi
S
S
Petri
P L
PL
Capecchi
T
T
Di Perri
D000368:Aged; D002637:Chest Pain / Q000209:etiology; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D004176:Dipyridamole / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004452:Echocardiography; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D015994:Incidence; D007262:Infusions, Intravenous; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D014665:Vasodilator Agents / Q000008:administration & dosage*
D014665:Vasodilator Agents; D004176:Dipyridamole