Cell surface alterations in embryonic tissues exposed to RGD-peptides: selective expression.
Whole animal studies have implicated cell adhesion molecules in a diverse array of developmental processes. The present study reports on the morphological effects of RGD-related peptides on the cell surface of various living chick embryonic tissues. We report a novel and characteristic plasma membrane reaction that is caused by treatment with different RGD-peptides. Not only does each peptide evoke a response in certain tissues and not in others, but each brings about a specific type of plasma membrane reaction (bleb). Although the mechanisms are unknown, the specificity of this phenomenon suggests that it could provide a window into new surface interactions in morphogenetic systems.
Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, USA.
J W
JW
Lash
K M
KM
Yamada
R
R
Bellairs
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects* / Q000648:ultrastructure; D002642:Chick Embryo; D005314:Embryonic and Fetal Development; D008648:Mesoderm / Q000187:drug effects; D008855:Microscopy, Electron, Scanning; D009024:Morphogenesis; D009432:Neural Crest / Q000166:cytology / Q000187:drug effects; D009842:Oligopeptides / Q000494:pharmacology*; D019096:Vitronectin / Q000494:pharmacology
D009842:Oligopeptides; D019096:Vitronectin; C047981:arginyl-glycyl-aspartic acid