Use of ADCON-L to inhibit postoperative peridural fibrosis and related symptoms following lumbar disc surgery: a preliminary report.
METHODS
This was a prospective, randomized, multicenter, double-blind study.


OBJECTIVE
The study evaluated the use of ADCON-L Anti-Adhesion Barrier Gel to inhibit peridural fibrosis and reduce fibrosis-related symptoms after first-time lumbar discectomy.


BACKGROUND
Peridural scarring causes tethering of dura and nerve roots, contributing to pain and functional limitation, and that symptoms are evident by 6 months after surgery.


METHODS
Following discectomy, ADCON-L was applied to patients in the active treatment group. Outcome measures were reduction of peridural scar and postoperative pain.


RESULTS
There is an association between peridural scar and recurrent radicular pain. Patients having extensive peridural scar were three times more likely to experience recurrent radicular pain than those patients with less extensive scarring. ADCON-L inhibited peridural scar. Compared to the control group, there was a 23% reduction in the number of patients with extensive peridural scar and a 120% increase in the number of patients having minimal or no scar. ADCON-L reduced the incidence of activity-related pain. There was up to a 50% reduction in the number of patients reporting increased pain while doing typical activities of daily living.


CONCLUSIONS
ADCON-L is safe, reduces peridural fibrosis, and improves postoperative patient outcome.
Gliatech Inc., Cleveland, OH 44122, USA.
J L
JL
Petrie
J S
JS
Ross
D000328:Adult; D002921:Cicatrix / Q000453:epidemiology / Q000517:prevention & control; D004311:Double-Blind Method; D004388:Dura Mater / Q000187:drug effects / Q000473:pathology*; D005260:Female; D005355:Fibrosis; D005782:Gels / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D015994:Incidence; D007403:Intervertebral Disc / Q000601:surgery*; D008159:Lumbar Vertebrae / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009930:Organic Chemicals; D010146:Pain; D010149:Postoperative Pain; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D013118:Spinal Cord Diseases / Q000517:prevention & control
C104199:ADCON-L; D005782:Gels; D009930:Organic Chemicals