Human metabolism of paracetamol (acetaminophen) at different dose levels.
Urine (0-24 h) was collected from five subjects on separate occasions following the ingestion of paracetamol at five different dose levels (500, 750, 1000, 1250, 1500 mg) which spanned the normal therapeutic range. The major urinary metabolites were sulphuric and glucuronic acid conjugates which together accounted for around 50% of the administered dose. Unchanged paracetamol excretion was low (5-20%). This situation was similar over the entire dose range. These findings are discussed in relation to previous single dose studies reported in the literature.
Steventon
G B
GB
Biomedical Sciences Group, University of the West of England, Bristol, UK.
Mitchell
S C
SC
Waring
R H
RH
D000082:Acetaminophen / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D004305:Dose-Response Relationship, Drug; D005260:Female; D005965:Glucuronates / Q000652:urine; D006801:Humans; D008297:Male; D008875:Middle Aged; D013431:Sulfates / Q000652:urine
D018712:Analgesics, Non-Narcotic; D005965:Glucuronates; D013431:Sulfates; D000082:Acetaminophen