Sequence variation in the src gene product affects metastasis formation: the central, but not exclusive, role of the tumor immune response.
Sequence variation in the src gene product could, in principle, influence metastasis formation through either of 2 effects: an alteration in tumor antigenicity or a non-immune-mediated change in one or more src-associated functions. Our present results establish that both mechanisms underlie the difference in relative levels of metastasis formation induced by the v-src vs. the c-src(527) oncogene. A point that emerges from this analysis is the segregation, within a chicken line genotypically uniform at the major histocompatibility (B) complex (MHC), of a phenotype defined by strong resistance to secondary v-src-induced tumor challenge. The pattern of segregation is consonant with the possibility that a gene unlinked to the MHC governs immune response levels to v-src-encoded tumor antigen.
Department of Animal and Nutritional Sciences, University of New Hampshire, Durham, USA.
R L
RL
Taylor
J M
JM
England
G C
GC
Kopen
A A
AA
Christou
M S
MS
Halpern
D000818:Animals; D002645:Chickens; D000939:Epitopes; D016391:Genes, src / Q000235:genetics; D009362:Neoplasm Metastasis / Q000235:genetics / Q000276:immunology*; D009374:Neoplasms, Experimental / Q000235:genetics / Q000276:immunology*; D016392:Proto-Oncogene Proteins pp60(c-src) / Q000235:genetics* / Q000276:immunology; D013045:Species Specificity
D000939:Epitopes; D016392:Proto-Oncogene Proteins pp60(c-src)