Suramin-induced neutropenia.
This paper presents a retrospective review of 6 cases of severe neutropenia attributed to suramin, the response to granulocyte-colony stimulating factor (G-CSF) and the possible mechanism. Plasma suramin concentrations, G-CSF, platelet-derived growth factor-AB (PDGF-AB) and fibroblast growth factor basic (FGF basic) levels were measured and correlated with neutropenic course. The time course of neutropenia was unpredictable and occurred both during and following discontinuation of suramin. Neutropenia rapidly resolved with G-CSF. Neither the measured growth factor levels nor plasma suramin concentrations correlated with neutropenia. We conclude that neutropenia secondary to suramin is unpredictable and responds to G-CSF administration permitting further suramin therapy. The mechanism remains unknown.
Clinical Pharmacology Branch, National Cancer Institute, Bethesda, Maryland, USA.
N A
NA
Dawson
R M
RM
Lush
S M
SM
Steinberg
A C
AC
Tompkins
D J
DJ
Headlee
W D
WD
Figg
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001499:Bayes Theorem; D016222:Fibroblast Growth Factor 2 / Q000097:blood; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000097:blood / Q000139:chemically induced* / Q000628:therapy; D010982:Platelet-Derived Growth Factor / Q000032:analysis; D011471:Prostatic Neoplasms / Q000097:blood / Q000188:drug therapy / Q000473:pathology; D012189:Retrospective Studies; D013498:Suramin / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use
D000970:Antineoplastic Agents; D010982:Platelet-Derived Growth Factor; D016222:Fibroblast Growth Factor 2; D016179:Granulocyte Colony-Stimulating Factor; D013498:Suramin