Roxithromycin-induced digoxin toxicity.
A 76-year-old women presented with digoxin toxicity four days after starting a course of roxithromycin. In 10%-15% of the population, digoxin is degraded extensively by bacteria in the gastrointestinal tract, and antibiotic-induced changes in the bacterial flora may lead to digoxin toxicity.
Corallo
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Pharmacy Department, Box Hill Hospital, VIC.
Rogers
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IR
D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D004077:Digoxin / Q000097:blood / Q000506:poisoning*; D004347:Drug Interactions; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006327:Heart Block / Q000139:chemically induced; D006801:Humans; D007422:Intestines / Q000382:microbiology; D015575:Roxithromycin / Q000009:adverse effects* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D015575:Roxithromycin; D004077:Digoxin