DNA and mRNA sequence of the immune protective DNA ligase I gene match the rev response element of HIV.
A motif search for DNA and mRNA sequences matching the rev response core element of HIV identified only DNA ligase I to display the element both in DNA and mRNA and to have phylogenetic conservation of it. Genetic impairment of DNA ligase I is already known to lead to severe immunodeficiency in man. A similar impairment may result from HIV rev protein binding to the DNA ligase I mRNA.
Dandekar
T
T
European Molecular Biology Laboratory, Heidelberg, Germany.
Koch
G
G
D000818:Animals; D001483:Base Sequence; D004247:DNA; D000072481:DNA Ligase ATP; D011088:DNA Ligases / Q000235:genetics*; D015694:Gene Products, rev / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D012333:RNA, Messenger
D015694:Gene Products, rev; C000607892:LIG1 protein, human; D012333:RNA, Messenger; D004247:DNA; D011088:DNA Ligases; D000072481:DNA Ligase ATP