The Th1/Th2 paradigm and the allograft response.
Although Th1- and Th2-type cytokine profiles have been associated with rejection and tolerance respectively, this paradigm may not be completely accurate. Instead, recent studies suggest that there could be a hierarchy of T-cell growth factors with regard to their ability to block tolerance and induce rejection (rather than a polarized Th1/Th2 demarcation).
Strom
T B
TB
Department of Medicine, Harvard Medical School, Beth Israel Hospital, Boston, MA 02115, USA. tstrom@bih.harvard.edu
Roy-Chaudhury
P
P
Manfro
R
R
Zheng
X X
XX
Nickerson
P W
PW
Wood
K
K
Bushell
A
A
D000818:Animals; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D007108:Immune Tolerance; D007376:Interleukin-2 / Q000276:immunology; D051379:Mice; D008954:Models, Biological; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D007376:Interleukin-2