A combined management protocol for patients with coagulation disorders infected with hepatitis C virus.
The case notes of 394 adults with bleeding disorders registered at our centre together with those of the 72 patients who had died since 1971 were reviewed. 36/72 deceased patients had evidence of HCV infection. Liver decompensation was present at time of death in six. 274 (70%) of the currently registered patients had received factor concentrate or cryoprecipitate and 174 of these were screened for HCV infection. 76% of tested patients were RIBA positive. 87% of RIBA-positive patients were RT-PCR positive. 50 RIBA-positive patients, including nine who were HIV infected, have undergone percutaneous liver biopsy following appropriate factor infusion with no complication. The biopsy was assessed using a Histological Activity Index (HAI) ranging from 0 to 13. Patients with HAI > or = 6 were offered treatment with interferon. Patients with HAI < 6 were followed up with a view to re-biopsy in 2-3 years to assess progression. The median HAI was 4.5 (range 0-10) with HAI > or = 6 in 13 cases (27%). HAI was not correlated with duration of infection. haemophilia severity. RT-PCR status. HIV status or HCV genotype. Liver biopsy, a safe procedure in our hands, is an important investigation in HCV-infected patients to assess suitability for interferon therapy.
Ahmed
M M
MM
Liver Unit, University Hospital Birmingham NHS Trust.
Mutimer
D J
DJ
Elias
E
E
Linin
J
J
Garrido
M
M
Hubscher
S
S
Jarvis
L
L
Simmonds
P
P
Wilde
J T
JT
D000328:Adult; D001707:Biopsy, Needle; D001778:Blood Coagulation Disorders / Q000150:complications / Q000628:therapy*; D016913:Blood Component Transfusion; D002985:Clinical Protocols; D005260:Female; D006526:Hepatitis C / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D014761:Viral Hepatitis Vaccines
D014761:Viral Hepatitis Vaccines