Reduced decrease of peripheral vascular resistance during exercise in young type I diabetic patients.
OBJECTIVE
In normal subjects, peripheral vascular resistance decreases during dynamic exercise. We studied blood pressure and peripheral vascular resistance responses to dynamic exercise in young normotensive type I diabetic patients.


METHODS
Thirty adolescent diabetic patients (9-19 years of age) underwent a maximal exercise test on a cycle ergometer. In a subset of 14 patients, cardiac output was measured by a CO2 rebreathing method and peripheral vascular resistance was calculated. Twenty-four normal individuals, age and sex matched, served as control subjects.


RESULTS
Diastolic blood pressure was significantly higher in diabetic patients at intermediate workload (77 +/- 2 vs. 71 +/- 1 mmHg) and peak exercise (86 +/- 2 vs. 73 +/- 2 mmHg). Peripheral vascular resistance was significantly higher in diabetic patients at intermediate workload (17.0 +/- 1.1 vs. 12.6 +/- 0.5 mmHg.l-1.min-1.m-2) and peak exercise (16.3 +/- 1.3 vs. 11.4 +/- 0.5 mmHg.l-1.min-1.m-2). There were no significant correlations with the patient's age, diabetes duration, or diabetes control.


CONCLUSIONS
We observed the decrease of vasodilator response during dynamic exercise in normotensive young type I diabetic patients.
Department of Pediatrics, University Hospital Gent, Belgium. dirk.matthys@rug.ac.be
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D
Matthys
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M
Craen
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D
De Wolf
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Vande Walle
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H
Verhaaren
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure; D002302:Cardiac Output; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003971:Diastole; D005080:Exercise Test; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D010101:Oxygen Consumption; D005082:Physical Exertion; D012016:Reference Values; D014655:Vascular Resistance; D014664:Vasodilation