Effects of nadolol and its combination with atrial pacing on rate-enhanced ventricular premature complexes.
To explore the role of heart rate in the genesis of ventricular premature complexes whose incidence increases when the length of the preceding cardiac cycle decreases, we analyzed the effect of nadolol alone and together with atrial pacing in 4 patients. Nadolol lengthened the RR cycle and suppressed ventricular premature complexes; atrial pacing, restoring the baseline RR cycle lengths, led to the reappearance of ventricular premature complexes, suggesting the major role of heart rate.
Institute of Cardiology, University of Bari, Italy.
M V
MV
Pitzalis
F
F
Mastropasqua
F
F
Massari
A
A
Passantino
G
G
Luzzi
C
C
Forleo
P
P
Rizzon
D000328:Adult; D002304:Cardiac Pacing, Artificial; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009248:Nadolol / Q000627:therapeutic use*; D018879:Ventricular Premature Complexes / Q000175:diagnosis / Q000628:therapy*
D009248:Nadolol