Studies of succinate dehydrogenase inhibition (SDI) test with cisplatin encapsulated liposome against cancer cells.
In the present study, by means of encapsulating into liposome, cisplatin was made a soluble capsule, and augmentation of the antitumor effect through the cell affinity of liposome was investigated by chemosensitivity test for cancer cells. Augmentation of the antitumor effect by collaboration of the cell affinity of liposome with the diffusion by concentration gradient was expected. However, although a difference in absorbancy was in fact observed, no statistically significant difference of effect superior to cisplatin alone was observed.
Koketsu
M
M
Department of Otolaryngology, Nagoya City University Medical School, Japan.
Suzuki
K
K
Yotsuyanagi
T
T
Baba
S
S
D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D002945:Cisplatin / Q000097:blood / Q000493:pharmacokinetics*; D008081:Liposomes / Q000378:metabolism*; D008297:Male; D051381:Rats; D012107:Research Design; D013385:Succinate Dehydrogenase / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000378:metabolism
D000970:Antineoplastic Agents; D008081:Liposomes; D013385:Succinate Dehydrogenase; D002945:Cisplatin