Increase of preproenkephalin mRNA in the caudal part of periaqueductal gray by morphine withdrawal in rats: a quantitative in situ hybridization study.
Effects of morphine withdrawal on the levels of preproenkephalin (PPE) mRNA in the area from lateral to ventrolateral periaqueductal gray (PAG) were studied in rats by quantitative in situ hybridization. PPE mRNA in the rostral PAG was decreased by naloxone-precipitated morphine withdrawal but not affected by spontaneous morphine withdrawal. PPE mRNA in the caudal PAG was increased by both spontaneous and naloxone-precipitated morphine withdrawal.
Department of Pharmacology, Wakayama Medical College, Japan.
Y
Y
Fukunaga
S
S
Nishida
N
N
Inoue
S
S
Kishioka
H
H
Yamamoto
D000818:Animals; D004745:Enkephalins / Q000235:genetics*; D017403:In Situ Hybridization; D008297:Male; D009020:Morphine / Q000009:adverse effects*; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D009294:Narcotics / Q000009:adverse effects*; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000378:metabolism; D010487:Periaqueductal Gray / Q000187:drug effects* / Q000378:metabolism; D011498:Protein Precursors / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*
D004745:Enkephalins; D009292:Narcotic Antagonists; D009294:Narcotics; D011498:Protein Precursors; D012333:RNA, Messenger; D009270:Naloxone; D009020:Morphine; C033660:preproenkephalin