The pathobiology of premature rupture of membranes.
Premature rupture of membranes arises from what are likely multifaceted and multistep pathogenic pathways. Pathophysiological processes may involve both endogenous and exogenous fetal and maternal factors. This article reviews and analyzes information regarding, first, the form and function of fetal membranes; second, how membranes physically fail (rupture) at term and preterm gestations; and third, evaluates if we can reduce risks of rupture using physiological understanding and evidence-based clinical studies.
Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver 80262, USA.
J I
JI
French
J A
JA
McGregor
D001696:Biomechanical Phenomena; D005321:Extraembryonic Membranes / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D007239:Infections / Q000150:complications; D009747:Nutritional Physiological Phenomena; D011247:Pregnancy; D012907:Smoking / Q000009:adverse effects; D014590:Uterine Contraction