Posttraining intrahippocampal estradiol injections enhance spatial memory in male rats: interaction with cholinergic systems.
Male Long-Evans rats received an 8-trial training session in a spatial water maze task, followed by a unilateral posttraining intrahippocampal injection of either estradiol (1.0 microgram/0.5 microliter) or saline. Retention was tested 24 hr later, and latency to escape was used as a measure of memory. Retention test escape latencies of rats given intrahippocampal injections of estradiol were lower than those of saline-treated rats, indicating an enhancement of memory. Intrahippocampal injections of estradiol delayed 2 hr posttraining did not affect retention. In Experiment 2, the memory enhancing effect of intrahippocampal injection of estradiol was blocked by peripheral administration of a subeffective dose (0.1 mg/kg) of the cholinergic antagonist scopolamine. Intrahippocampal injections of estradiol enhance memory in male rats, and estradiol may influence memory through an interaction with muscarinic cholinergic systems.
Packard
M G
MG
Department of Psychology, University of New Orleans, Louisiana 70148, USA. mgpps@uno.edu
Kohlmaier
J R
JR
Alexander
G M
GM
D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D018782:Maze Learning; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D051381:Rats; D012601:Scopolamine / Q000494:pharmacology*; D013037:Spatial Behavior / Q000502:physiology*
D018727:Muscarinic Antagonists; D004958:Estradiol; D012601:Scopolamine