Unusual chromosome aberration, t(13;14)(q32;q32.3), in a case of essential thrombocythemia with extreme thrombocytosis.
A case of essential thrombocythemia (ET) with extreme thrombocytosis in a 70-year-old male patient is described. The cytogenetic analysis revealed a pathologic clone with the following previously unreported, unusual karyotype: 46,XY,t(13;14)(q32:q32.3) and pericentric inversion of chromosome 9. The possible association of t(13;14) with the high platelet count is discussed.
Department of Cytogenetics, National Center of Oncology, Sofia, Bulgaria.
L
L
Mitev
G
G
Georgiev
A
A
Petrov
Y
Y
Manolova
D000368:Aged; D002869:Chromosome Aberrations / Q000235:genetics*; D007446:Chromosome Inversion; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D013920:Thrombocythemia, Essential / Q000150:complications / Q000235:genetics*; D013922:Thrombocytosis / Q000150:complications / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*