Vasculitis and lymphoproliferative diseases.
Vasculitis as a complication of lymphoproliferative diseases is relatively uncommon. Cutaneous vasculitis is most commonly necrotizing and leukocytoclastic. Granulomatous vasculitis occurs rarely with lymphoproliferative diseases, and even less commonly T-cell lymphocytic vasculitis with eosinophilia. The most common systemic vasculitis is caused by cryoglobulinemia, due to either lymphocytic lymphoma or Waldenström's macroglobulinemia. Other unusual associations involving systemic vasculitides include polyarteritis nodosa and hairy cell leukemia, Wegener's granulomatosis and Hodgkin's disease, granulomatous angiitis of the central nervous system and lymphoma, temporal arteritis and lymphoma, and Henoch-Schönlein purpura and lymphoma. The vasculitis may predate the diagnosis of the lymphoproliferative disease, and patients with vasculitis should be screened and monitored for lymphoproliferative diseases.
Wooten
M D
MD
Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock 72205, USA.
Jasin
H E
HE
D003449:Cryoglobulinemia / Q000150:complications / Q000175:diagnosis; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000150:complications* / Q000276:immunology; D014657:Vasculitis / Q000209:etiology* / Q000276:immunology