Responses of serum lipids and adipose tissue lipases to lipopolysaccharide administration in normal and hepatoma-bearing rats.
The effects of in vivo lipopolysaccharide administration on serum lipid metabolism were studied in normal and hepatoma-bearing rats. Changes in serum lipid levels and adipose tissue lipase (lipoprotein lipase and hormone-sensitive lipase) activities following injection of lipopolysaccharide into normal rats resembled those in hepatoma-bearing rats. These results suggest the presence of some common factor(s) involved in the incidence of abnormal lipid metabolism upon lipopolysaccharide injection and hepatoma transplantation.
Kawasaki
M
M
Department of Applied Biological Science, Tokyo Noko University, Japan.
Yagasaki
K
K
Miura
Y
Y
Funabiki
R
R
D000273:Adipose Tissue / Q000187:drug effects / Q000201:enzymology*; D000818:Animals; D006949:Hyperlipidemias / Q000097:blood / Q000201:enzymology / Q000378:metabolism; D008055:Lipids / Q000097:blood*; D008070:Lipopolysaccharides / Q000633:toxicity*; D008071:Lipoprotein Lipase / Q000187:drug effects / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000097:blood / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
D008055:Lipids; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D008071:Lipoprotein Lipase