Essential fatty acids and abnormal involuntary movements in the general male population: a study of men born in 1933.
Spontaneous and tardive dyskinesias were studied in a random population sample of 446 men, aged 59 years. Dyskinesia, defined as an AIMS score of at least 2 in any body part, was seen in 15.1% (n = 74). Dyskinetic men had a higher cigarette consumption, and they had higher frequencies of psychiatric morbidity and exposure to neuroleptics. Dyskinesia was also associated with several abnormalities in EFA concentrations in plasma, but the most consistent finding was the low arachidonic acid levels in phospholipids, triglycerides and cholesterol esters. In a logistic regression model, cigarette consumption (P < 0.02), exposure to neuroleptics (P < 0.01), and low arachidonic acid levels in the phospholipid fraction (P < 0.0001) were independently associated with dyskinesia.
Nilsson
A
A
Karsudden Hospital, Katrineholm, Sweden.
Horrobin
D F
DF
Rosengren
A
A
Waller
L
L
Adlerberth
A
A
Wilhelmsen
L
L
D014150:Antipsychotic Agents / Q000009:adverse effects; D015331:Cohort Studies; D005227:Fatty Acids / Q000097:blood; D005228:Fatty Acids, Essential / Q000097:blood*; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D016017:Odds Ratio; D010743:Phospholipids / Q000737:chemistry*; D015995:Prevalence; D011446:Prospective Studies; D012907:Smoking / Q000009:adverse effects
D014150:Antipsychotic Agents; D005227:Fatty Acids; D005228:Fatty Acids, Essential; D010743:Phospholipids