Strategies for the treatment of recurrent acute lymphoblastic leukemia in adults.
Bone marrow recurrence of adult acute lymphoblastic leukemia is typically an aggressive and most often rapidly fatal condition, an ideal setting for testing the latest research developments and experimental therapeutic options. Here we review recurrence mechanisms and treatment possibilities in order to identify the most appropriate clinical conduct. Choice of retreatment drugs and their dosages, related or unrelated donor bone marrow transplants, autologous peripheral blood stem cell transplants, immune manipulations, reversal of drug resistance, and restoration of apoptosis are all part of an integrated short-term therapeutic and decisional network to be developed for specific patient and disease prognostic subgroups.
Divisione di Ematologia, Ospedali Riuniti, Bergamo, Italy.
R
R
Bassan
T
T
Lerede
T
T
Barbui
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D006801:Humans; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D012008:Recurrence; D012307:Risk Factors
D000970:Antineoplastic Agents