Specific skin infiltration as first sign of chronic myelomonocytic leukemia with an unusual phenotype.
A patient who had a plaque on his forehead as the first sign of chronic myelomonocytic leukemia (CMML) is described. Histologic studies, which formerly led to the misdiagnosis of non-Hodgkin's lymphoma, revealed CMML with an unusual phenotype. This represents a rare type of CMML for the following reasons: (1) specific cutaneous involvement is rarely the first sign of CMML; (2) the unique phenotype was detected by immunohistology on lesional skin, specifically, the leukemic infiltrate was CD4-positive and notably negative for CD15, the pan myeloid/monocytic marker.
Braga
D
D
Department of Dermatology Spedali Civili, Brescia, Italy.
Manganoni
A M
AM
Boccaletti
V
V
Pancera
C
C
Marocolo
D
D
Facchetti
F
F
De Panfilis
G
G
D000368:Aged; D015703:Antigens, CD; D006801:Humans; D016130:Immunophenotyping; D015477:Leukemia, Myelomonocytic, Chronic / Q000276:immunology / Q000473:pathology*; D017254:Leukemic Infiltration; D008297:Male; D012867:Skin / Q000473:pathology*
D015703:Antigens, CD