Selective elevation of monocyte chemotactic protein-1 in the cerebrospinal fluid of AIDS patients with cytomegalovirus encephalitis.
The CC chemokine monocyte chemotactic protein-1 (MCP-1) was markedly elevated in the cerebrospinal fluid (CSF) of human immunodeficiency virus (HIV)-infected patients with cytomegalovirus (CMV) encephalitis. The MCP-1 CSF levels in CMV encephalitis were markedly higher than those in the CSF of HIV-infected patients with or without unrelated neurologic diseases, including progressive multifocal leukoencephalopathy, cryptococcal meningitis, toxoplasmic encephalitis, and primary lymphoma. Interleukin-8, RANTES, macrophage inflammatory protein (MIP)-1 alpha, and MIP-1 beta were not substantially increased in the CSF of CMV encephalitis patients. High levels of MCP-1 may underlie monocyte recruitment and tissue damage in CMV encephalitis and may represent a rapid and useful tool in the diagnostic armamentarium for neurologic disorders associated with HIV infection.
Istituto di Ricerche Farmacologiche Mario Negri DIBIT, Milan, Italy.
S
S
Bernasconi
P
P
Cinque
G
G
Peri
S
S
Sozzani
A
A
Crociati
W
W
Torri
E
E
Vicenzi
L
L
Vago
A
A
Lazzarin
G
G
Poli
A
A
Mantovani
D017088:AIDS-Related Opportunistic Infections / Q000134:cerebrospinal fluid*; D018932:Chemokine CCL2 / Q000134:cerebrospinal fluid*; D003586:Cytomegalovirus Infections / Q000134:cerebrospinal fluid*; D018792:Encephalitis, Viral / Q000134:cerebrospinal fluid*; D006801:Humans
D018932:Chemokine CCL2