An evaluation of a dentifrice containing salivary peroxidase elements for the control of gingival disease in patients with irradiated head and neck cancer.
Patients who have undergone irradiation for head and neck tumors commonly have xerostomia. Loss of the protective constituents normally found in saliva leaves patients at greater risk for development of significant dental pathologic disorders, including gingival and periodontal disease. Periodontal disease and tooth extractions are currently accepted as etiologic factors for the development of osteoradionecrosis. This double-blind crossover trial was conducted to assess the efficacy of a dentifrice containing salivary peroxidase elements in the reduction of gingivitis in a population of patients with irradiated cancer. Subjects were instructed to brush with the dentifrice provided. Plaque and gingival index values were obtained and statistically compared with baseline values. A weak positive effect was found between use of the dentifrice and a reduction in gingival inflammation. Patient compliance was a limiting factor in this treatment effect. The results suggest possible efficacy for the dentifrice in augmenting traditional measures of postradiation oral health maintenance.
Toljanic
J A
JA
Department of Surgery, University of Chicago, USA.
Siddiqui
A A
AA
Patterson
G L
GL
Irwin
M E
ME
D016371:Cranial Irradiation / Q000009:adverse effects*; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000209:etiology / Q000517:prevention & control; D003774:Dental Plaque Index; D003802:Dentifrices / Q000737:chemistry / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005882:Gingival Diseases / Q000209:etiology / Q000517:prevention & control*; D006258:Head and Neck Neoplasms / Q000532:radiotherapy; D006801:Humans; D008297:Male; D010349:Patient Compliance; D010512:Periodontal Index; D010544:Peroxidases / Q000627:therapeutic use*; D012463:Saliva / Q000201:enzymology*; D012471:Salivary Proteins and Peptides / Q000627:therapeutic use*; D016896:Treatment Outcome; D014987:Xerostomia / Q000150:complications / Q000209:etiology
D003802:Dentifrices; D012471:Salivary Proteins and Peptides; D010544:Peroxidases