Regulation of the actin cytoskeleton, integrins and cell growth by the Rho family of small GTPases.
The Rho family of small GTP binding proteins play a key part in regulating the actin cytoskeleton and cell adhesion through integrin receptors. In addition, these proteins regulate signal transduction pathways essential for normal cell growth. Many of the molecules that regulate Rho have oncogenic activity, suggesting that members of the Rho family may have an important role in tumour formation.
Hotchin
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MRC Laboratory for Molecular Cell Biology, University College, London.
Hall
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A
D000199:Actins; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002455:Cell Division; D003599:Cytoskeleton / Q000502:physiology*; D020558:GTP Phosphohydrolases / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D016023:Integrins / Q000502:physiology*; D009369:Neoplasms / Q000209:etiology; D015398:Signal Transduction / Q000502:physiology
D000199:Actins; D016023:Integrins; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins