Neural BC1 RNA in mouse skeletal muscle is a denervation-induced RNA whose expression is developmentally regulated.
We detected neural BC1 RNA in mouse skeletal muscle. The level of BC1 RNA was high in the fetus, but it declined progressively to the adult level as development proceeded. These observations suggest that this RNA is involved in the prenatal development and differentiation of muscles. Although its developmental expression correlates with the fetal period of polyneuronal innervation, BC1 RNA does not seem to play a direct role(s) in synaptogenesis, since its expression was not restricted to the neuromuscular junction. We also demonstrated that the BC1 RNA level in adult muscle was elevated after denervation, suggesting that changes in the activity of muscles or neural factors caused by axotomy, or both may result in BC1 RNA upregulation.
Division of Molecular Cell Biology, College of Pharmacy, Nihon University, Chiba, Japan.
K
K
Anzai
S
S
Kobayashi
H
H
Kotake
H
H
Murakami
K
K
Korematsu
I
I
Nonaka
D000199:Actins / Q000235:genetics; D000367:Age Factors; D000818:Animals; D001369:Axons / Q000502:physiology; D015152:Blotting, Northern; D004268:DNA-Binding Proteins / Q000235:genetics*; D003714:Denervation; D003964:Diaphragm / Q000737:chemistry / Q000201:enzymology / Q000294:innervation; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D051379:Mice; D018482:Muscle, Skeletal / Q000737:chemistry* / Q000201:enzymology / Q000294:innervation; D009469:Neuromuscular Junction / Q000737:chemistry / Q000502:physiology; D012320:RNA Polymerase III / Q000235:genetics; D062085:RNA, Long Noncoding; D012333:RNA, Messenger / Q000032:analysis; D022661:RNA, Untranslated; D011978:Receptors, Nicotinic / Q000235:genetics; D012261:Ribonucleoproteins / Q000235:genetics*; D020736:Ribonucleoproteins, Small Cytoplasmic; D012584:Sciatic Nerve / Q000601:surgery / Q000648:ultrastructure; D009435:Synaptic Transmission / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology
D000199:Actins; C076675:Bc1 long-non-coding RNA, mouse; D004268:DNA-Binding Proteins; D062085:RNA, Long Noncoding; D012333:RNA, Messenger; D022661:RNA, Untranslated; D011978:Receptors, Nicotinic; D012261:Ribonucleoproteins; D020736:Ribonucleoproteins, Small Cytoplasmic; D012320:RNA Polymerase III