Uptake1, Uptake2 and release of 3H-noradrenaline in ovarian artery and in subovarian veno-arterial network of pigs during the ovarian cycle.
Uptake1, Uptake2 and the release 3H-noradrenaline in ovarian artery (Oa) and in subovarian veno-arterial network (Sn) of pigs were studied on days 0, 1-2, 13-14 and 16-18 of the ovarian cycle. It was found that Uptake1 in Oa and in Sn was the lowest on the day of ovulation (day 0 = 100%) and then it increased in Sn by 59.9% (p < 0.05) on days 1-2, and was the highest on days 13-14 in Oa = 166.6% (p < 0.05) and in Sn = 208.8% (p < 0.01) and next it decreased on days 16-18 in Oa to 101.5% and in Sn to 136.0% (p < 0.05) in comparison with the day 0. Uptake2 in Oa and Sn was the lowest on the day 0 (100%) and the similarly low on days 16-18 of the estrous cycle, whereas it was markedly higher (p < 0.05) on days 1-2 by 56.2% and by 57.9% in Oa and Sn, and on days 13-14 by 34.1% and by 34.7% in Oa and Sn respectively. The spontaneous release of neuronal radioactivity in Oa was markedly higher only on days 16-18 (by 40.2-53.4%; p < 0.05), whereas release of extraneuronal radioactivity in Oa was the highest on the day O, and significantly lower (p < 0.05) on days 1-2 by 46.6-50.5%, on days 13-14 by 45.0-55.0%, and on days 16-18 by 58.5-61.7%. The spontaneous release of neuronal radioactivity in Sn was the highest on the day O and on days 16-18, whereas it was lower (p < 0.05) on days 1-2 by 53.7-55.6% and on days 13-14 by 36.0-46.4%. It seems that Uptake1 increase and simultaneously the decrease of NA neuronal release in subovarian veno-arterial network during luteal phase can be one of condition mechanisms leading to diminution of ovarian vessels tension and rise of ovarian blood flow.
Department of Pharmacology, Faculty of Veterinary Medicine, Olsztyn University of Agriculture and Technology, Poland.
I
I
Dynarowicz
T
T
Pirus
T
T
Trapkowski
D000704:Analysis of Variance; D000818:Animals; D001158:Arteries / Q000294:innervation*; D001692:Biological Transport; D004971:Estrus; D005260:Female; D066298:In Vitro Techniques; D009131:Muscle, Smooth, Vascular / Q000294:innervation; D009474:Neurons / Q000502:physiology*; D009638:Norepinephrine / Q000097:blood / Q000378:metabolism*; D010053:Ovary / Q000098:blood supply / Q000502:physiology*; D013552:Swine; D014680:Veins
D009638:Norepinephrine