Is tolerance induction a possible mode of action of OM-89?
Neonatal Wistar rats were injected intraperitoneally with either 20 mu g OM-89 at birth and on day 3 after birth or 2 mg three times weekly until 200 g body weight. At this weight, groups were either implanted subcutaneously with a cotton pellet to induce granuloma, or had avridine polyarthritis or pleurisy induced. Both OM-89 treatment regimes significantly reduced granuloma weight (p < 0.05 and < 0.01), paw volume (p < 0.001) and pleural exudates (p < 0.01). The results suggest that OM-89 could work via tolerance induction.
Department of Experimental Pathology, St. Bartholomew's Hospital Medical College, London, UK.
D
D
Willis
A R
AR
Moore
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G
Gowland
D A
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Willoughby
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000941:Antigens / Q000097:blood*; D000942:Antigens, Bacterial; D001168:Arthritis / Q000139:chemically induced; D002908:Chronic Disease; D003959:Diamines; D004195:Disease Models, Animal; D004361:Drug Tolerance; D004926:Escherichia coli; D007249:Inflammation / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D013601:T-Lymphocytes / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000941:Antigens; D000942:Antigens, Bacterial; D003959:Diamines; C050501:OM 89; C006270:avridine