The reovirus nonstructural protein sigma1NS is recognized by murine cytotoxic T lymphocytes.
The cytotoxic T-lymphocyte (CTL) response in reovirus-infected C3H mice was investigated by using reovirus-vaccinia virus recombinants. Results of cytotoxicity assays indicated that the nonstructural protein sigma1NS elicited a significant CTL response. Experiments with sigma1NS-specific CTL lines showed that both strain-specific and cross-reactive epitopes exist in the sigma1NS protein.
Hoffman
L M
LM
Department of Microbiology, Medical College of Wisconsin, Milwaukee 53226, USA.
Hogan
K T
KT
Cashdollar
L W
LW
D000818:Animals; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology*; D001483:Base Sequence; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic; D005822:Genetic Vectors; D007739:L Cells; D012089:Mammalian orthoreovirus 3 / Q000235:genetics / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D008969:Molecular Sequence Data; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology / Q000276:immunology*; D014616:Vaccinia virus / Q000235:genetics; D017361:Viral Nonstructural Proteins / Q000235:genetics / Q000276:immunology*
D000956:Antigens, Viral; D017361:Viral Nonstructural Proteins; C071901:sigma 1NS protein, Reovirus