[Superantigens and their behavior in the immune response].
Superantigens are a group of molecules produced by bacteria, viruses and parasites that stimulate T lymphocytes in a very potent way. They join the TCR-HLA complex from the outside, not through the classical peptide-bound mechanism, so that they can easily trigger the citokyne production network and produce tissue damage, they can also lead to clonal anergy over the CD4 T cell subpopulations (Th0/Th1/Th2).
inmunología clínica y alergia, Hospital Lic. Adolfo López Mateos, ISSSTE, México.
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López
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Sandoval
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Vera
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Solano
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology; D001402:B-Lymphocytes / Q000821:virology; D001427:Bacterial Toxins / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D017635:Clonal Anergy; D000949:Histocompatibility Antigens Class II / Q000276:immunology / Q000378:metabolism; D006801:Humans; D009052:Leukemia Virus, Murine / Q000276:immunology; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000378:metabolism; D008324:Mammary Tumor Virus, Mouse / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000378:metabolism; D012772:Shock, Septic / Q000209:etiology; D018089:Superantigens / Q000276:immunology* / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D014412:Tumor Virus Infections / Q000276:immunology / Q000821:virology
D000942:Antigens, Bacterial; D000956:Antigens, Viral; D001427:Bacterial Toxins; D000949:Histocompatibility Antigens Class II; D008222:Lymphokines; D011948:Receptors, Antigen, T-Cell; D018089:Superantigens