Ovarian germ cell tumor with chromosome 12 anomaly but without i(12p).
Cytogenetic data on ovarian germ cell tumors are scarce. Abnormalities of chromosome 12, however, seem to be recurrent, and among these are small metacentrics assumed to be i(12p) as in other germ cell tumors. We here present evidence that a similar, small metacentric found in an ovarian dysgerminoma is a derivative of chromosome 12 but is not an i(12p).
Dal Cin
P
P
Center for Human Genetics, University of Leuven, Belgium.
Marynen
P
P
Moerman
P
P
Vergot
I
I
Van den Berghe
H
H
D000328:Adult; D002869:Chromosome Aberrations / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D005260:Female; D018237:Germinoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology