Disproportional arterial hypertrophy in hypertensive mRen-2 transgenic rats.
In the present study, we investigated the role of enhanced vascular renin-angiotensin activity in vascular hypertrophy. We used transgenic (mRen-2)27 (renin TGR) rats, spontaneously hypertensive rats (SHR), and their respective normotensive control rats to study in situ pressure-diameter relationships in second-generation mesenteric arterial branches (in vivo diameter, 400 to 500 microns) over a pressure range of 0 to 200 mm Hg. We studied pressure-diameter curves under both control (Tyrode's solution) and fully relaxed (Tyrode's solution containing 100 mg/L potassium cyanide) conditions. From these curves, we determined mechanical properties at operating blood pressure. In both hypertensive strains, mesenteric arterial media cross-sectional area was increased, with a significantly (P < .05) stronger degree of hypertrophy in renin TGR rats. Arterial distensibility of relaxed vessels was decreased to an equal degree in both hypertensive strains. Under control conditions, distensibility was higher in SHR than in renin TGR rats but still significantly reduced compared with distensibility in normotensive rats. Wall tension was increased to an equal degree in both hypertensive strains, whereas circumferential wall stress was normal in SHR but significantly (P < .05) reduced in renin TGR rats. These results indicate that whereas vascular hypertrophy in SHR causes adaptive normalization of arterial wall stress, enhanced vascular renin-angiotensin activity causes vascular hypertrophy in excess of the hypertrophy associated with pressure elevation alone.
Struijker-Boudier
H A
HA
Department of Pharmacology, Cardiovascular Research Institute Maastricht, University of Limburg, The Netherlands. h.struijkerboudier@farmaco.rulimburg.nl
van Essen
H
H
Fazzi
G
G
De Mey
J G
JG
Qiu
H Y
HY
Lévy
B I
BI
D000818:Animals; D006973:Hypertension / Q000235:genetics* / Q000378:metabolism; D006984:Hypertrophy; D008638:Mesenteric Arteries; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000473:pathology*; D011312:Pressure; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012084:Renin-Angiotensin System / Q000502:physiology*; D013045:Species Specificity