The effect of 2,4-dichlorophenol on lipid peroxidation in tissues of guinea pigs with different ascorbic acid intake.
Chlorinated phenols are widely used in the manufacture of biocides and wood preservatives. 2,4-dichlorophenol administered perorally 3 times a week at a dose of 40 mg in 0.2 ml of olive oil per kg of body weight to guinea pigs increased lipid peroxidation in liver and adrenals after 2 weeks of treatment. A high intake of ascorbic acid (50 mg/animal/day) significantly decreased lipid peroxidation in the liver of 2, 4-dichlorophenol treated guinea pigs in comparison to guinea pigs with low ascorbic acid intake (2 mg/animal/day). 2,4-dichlorophenol accumulation was also decreased in the liver of animals with high ascorbic acid intake. Increased daily intake of vitamin C to persons involved in production and use of chlorophenoxy herbicides is recommended.
Clerhata
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Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic. kovacik@enigma.upkm.sanet.sk
Kováciková
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Z
Veningerová
M
M
Lukácsová
M
M
Ginter
E
E
D000311:Adrenal Glands / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D002733:Chlorophenols / Q000494:pharmacology*; D006168:Guinea Pigs; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000378:metabolism; D008297:Male; D012044:Regression Analysis
D002733:Chlorophenols; D001205:Ascorbic Acid; C004762:2,4-dichlorophenol