Cardiac and skeletal muscle troponin I isoforms are encoded by a dispersed gene family on mouse chromosomes 1 and 7.
We mapped the locations of the genes encoding the slow skeletal muscle, fast skeletal muscle, and cardiac isoforms of troponin I (Tnni) in the mouse genome by interspecific hybrid backcross analysis of species-specific (C57BL/6 vs Mus spretus) restriction fragment length polymorphisms (RFLPs). The slow skeletal muscle troponin I locus (Tnni1) mapped to Chromosome (Chr) 1. The fast skeletal muscle troponin I locus (Tnni2), mapped to Chr 7, approximately 70 cM from the centromere. The cardiac troponin I locus (Tnni3) also mapped to Chr 7, approximately 5-10 cM from the centromere and unlinked to the fast skeletal muscle troponin I locus. Thus, the troponin I gene family is dispersed in the mouse genome.
Institut Pasteur de Paris, Unite de Genetique des mammiferes, Paris, France.
J L
JL
Guenet
D
D
Simon-Chazottes
M
M
Gravel
K E
KE
Hastings
S
S
Schiaffino
D000818:Animals; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D003433:Crosses, Genetic; D018076:DNA, Complementary / Q000235:genetics; D005786:Gene Expression Regulation / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D016678:Genome; D006239:Haplotypes / Q000235:genetics; D051379:Mice; D008815:Mice, Inbred Strains; D018482:Muscle, Skeletal / Q000737:chemistry; D009206:Myocardium / Q000737:chemistry; D009693:Nucleic Acid Hybridization; D012150:Polymorphism, Restriction Fragment Length; D019210:Troponin I / Q000737:chemistry* / Q000235:genetics*
D018076:DNA, Complementary; D005819:Genetic Markers; D019210:Troponin I