Phosphatidylcholine hydrolysis and protein kinase C activation for intracellular signaling network.
Agonist-stimulated inositol phospholipid hydrolysis by phospholipase C was once thought to be the sole mechanism to produce diacylgylcerol that transduce extracellular signals into intracellular events through activation of protein kinase C. It is becoming clear that agonist-induced hydrolysis, of the other membrane phospholipids, particularly phosphatidylcholine, by phospholipase A2 and phospholipase D also takes part in cellular responses such as cell proliferation and differentiation. Possibly, the members of the protein kinase C family may be activated differently by various combinations of phospholipid degradation products, and play each distinct role in signal transduction for the control of various cellular functions.
Department of Biochemistry, Kobe University School of Medicine, Japan.
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Nakamura
D000818:Animals; D004789:Enzyme Activation; D006801:Humans; D006868:Hydrolysis; D010713:Phosphatidylcholines / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism*; D015398:Signal Transduction
D010713:Phosphatidylcholines; D011493:Protein Kinase C