Can human polyclonal immunoglobulin raise the threshold for convulsions in rats?
In the present preliminary study we explored the possibility of an anticonvulsant effect of normal human immunoglobulin in an animal epilepsy model based on direct cortical stimulation in freely moving rats. After human immunoglobulin administration a significant and prolonged elevation of the threshold for convulsions was measured in 12% (6/49) of the total group of outbred Wistar rats. In the subgroup of more than seven months old Wistar rats this was 67% (6/9). When a threshold increasing effect of immunoglobulin occurred, it was detectable within 0.5-1 hour after administration, reached its maximum after approximately two hours and continued for at least 40 hours.
Institute of Neurology, University Hospital Nijmegen, The Netherlands.
B G
BG
van Engelen
I
I
van Den Beukel
R A
RA
Voskuyl
C M
CM
Weemaes
W O
WO
Renier
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000502:physiology; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology; D004558:Electric Stimulation; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007136:Immunoglobulins / Q000097:blood / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000473:pathology / Q000503:physiopathology*
D007136:Immunoglobulins