Lymphatic transport of alpha-, gamma- and delta-tocotrienols and alpha-tocopherol in rats.
Lymphatic transport of alpha-, gamma- and delta-tocotrienols and alpha-tocopherol was measured in thoracic duct-cannulated rats. Animals were administered 3 ml of a test emulsion containing 200 mg sodium taurocholate, 50 mg fatty acid free-albumin, 200 mg fat and 100 mg of a mixture of tocotrienols and alpha-tocopherol (Exp. 1) or 10 mg of purified alpha-, gamma- or delta-tocotrienol or alpha-tocopherol (Exp. 2) through a gastric tube. Quantitative lymphatic recovery of oleic acid given as triolein was obtained in these experimental conditions. The 24-hours recovery of tocotrienols and alpha-tocopherol were 10-20% of the administered dose in Exp. 1. The recovery of alpha-tocotrienol was about 2-times higher than that of alpha-tocopherol, while that of gamma- and delta-tocotrienols was intermediate between these two alpha-forms. In Exp. 2, where these compounds were administered individually, the 24 hours recovery ranged from 22 to 37% of the administered dose. Again, the recovery of alpha-tocotrienol was significantly higher than that of the other tocotrienols and alpha-tocopherol, while that of gamma- and delta-tocotrienols and alpha-tocopherol was comparable. Thus, the results show the preferential absorption of alpha-tocotrienol compared to gamma- and delta-tocotrienols and alpha-tocopherol.
Ikeda
I
I
Laboratory of Nutrition Chemistry, Kyushu University School of Agriculture, Fukuoka, Japan.
Imasato
Y
Y
Sasaki
E
E
Sugano
M
M
D000818:Animals; D001692:Biological Transport; D002839:Chromans / Q000378:metabolism*; D004655:Emulsions; D007408:Intestinal Absorption; D007700:Kinetics; D008208:Lymphatic System / Q000378:metabolism*; D008297:Male; D019301:Oleic Acid / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013897:Thoracic Duct; D024508:Tocotrienols; D014304:Triolein / Q000378:metabolism; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000378:metabolism
D002839:Chromans; D004655:Emulsions; D024508:Tocotrienols; D014304:Triolein; D014810:Vitamin E; C082097:tocotrienol, delta; D019301:Oleic Acid; C013649:plastochromanol 8; C082032:tocotrienol, alpha