Calcitonin gene-related peptide is a potent intestinal, but not gastric, vasodilator in conscious dogs.
The effects of human alpha-calcitonin gene-related peptide (alpha-CGRP), beta-CGRP, and vasoactive intestinal polypeptide (VIP) on left gastric (LGA) and superior mesenteric arterial (SMA) blood flow, heart rate and systemic arterial blood pressure were investigated in 6 conscious beagle dogs. Both intravenous injections of alpha-CGRP and beta-CGRP (5-200 pmol/kg) and infusion of alpha-CGRP (25-100 pmol/kg per h) induced a dose-related increase in SMA flow and a dose-related decrease in its resistance. At lower doses, alpha-CGRP was more potent than beta-CGRP, but their maximal responses were the same. alpha-CGRP and beta-CGRP had little effect on LGA flow. However, alpha-CGRP at 200 pmol/kg, but not beta-CGRP, stimulated gastroduodenal contractions that were associated with a phasic increase of LGA flow. Atropine inhibited gastric, but not duodenal, motor and circulatory responses to alpha-CGRP. Tachycardia and hypotension induced by beta-CGRP were significantly less than those by alpha-CGRP. VIP, on the other hand, increased mainly LGA flow. These results suggest that blood vessels of the small intestine of dogs are more sensitive to CGRP than those of the stomach, while the sensitivity to VIP is reversed.
National Institute for Physiological Sciences, Okazaki, Japan.
T
T
Nakamura
S
S
Naruse
T
T
Ozaki
K
K
Kumada
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology*; D004064:Digestive System / Q000187:drug effects*; D004285:Dogs; D004730:Endothelium, Vascular / Q000187:drug effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D013152:Splanchnic Circulation / Q000187:drug effects; D014655:Vascular Resistance; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology*
D014665:Vasodilator Agents; D014660:Vasoactive Intestinal Peptide; D001285:Atropine; D015740:Calcitonin Gene-Related Peptide