Mapping of a gene for Parkinson's disease to chromosome 4q21-q23.
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately 1 percent of the population over age 50. Recent studies have confirmed significant familial aggregation of PD and a large number of large multicase families have been documented. Genetic markers on chromosome 4q21-q23 were found to be linked to the PD phenotype in a large kindred with autosomal dominant PD, with a Zmax = 6.00 for marker D4S2380. This finding will facilitate identification of the gene and research on the pathogenesis of PD.
Laboratory of Genetic Disease Research, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD 20892-1430, USA.
M H
MH
Polymeropoulos
J J
JJ
Higgins
L I
LI
Golbe
W G
WG
Johnson
S E
SE
Ide
G
G
Di Iorio
G
G
Sanges
E S
ES
Stenroos
L T
LT
Pho
A A
AA
Schaffer
A M
AM
Lazzarini
R L
RL
Nussbaum
R C
RC
Duvoisin
D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D010300:Parkinson Disease / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype
D005819:Genetic Markers