Trifluoperazine is more effective than chlorpromazine in releasing oxygen from haemoglobin and myoglobin.
The extent of oxygen release from two heme proteins, haemoglobin and myoglobin have been studied in the presence of trifluoperazine and chlorpromazine (5-1000 microM). At a molar ratio (drug:protein) of 1.5, the release of oxygen from haemoglobin was 4 and 15% in the presence of chlorpromazine and trifluoperazine respectively, while from myoglobin the corresponding values were 20 and 40%. The findings were attributed to the greater extent of local conformational change around tryptophan moieties of each of the proteins induced by trifluoperazine.
Bhattacharyya
J
J
Department of Biophysics, Molecular Biology & Genetics, University of Calcutta, India.
Bhattacharyya
M
M
Chakraborti
A S
AS
Chaudhuri
U
U
Poddar
R K
RK
D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology*; D006454:Hemoglobins / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009211:Myoglobin / Q000187:drug effects / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D010108:Oxyhemoglobins / Q000187:drug effects / Q000378:metabolism; D014268:Trifluoperazine / Q000494:pharmacology*
D014150:Antipsychotic Agents; D006454:Hemoglobins; D009211:Myoglobin; D010108:Oxyhemoglobins; C017595:oxymyoglobin; D014268:Trifluoperazine; D002746:Chlorpromazine