Severe nontyphoidal salmonellosis probably in relation with omeprazole treatment: report of 2 cases.
We report 2 cases of severe nontyphoidal salmonellosis (Salmonella enteritidis), occurring 4 and 5 weeks after starting a treatment with Omeprazole (20 mg a day). No other member of the families was sick, and none of the 2 patients took any meals outside home during the two weeks preceding the first symptoms. Gastric hypochlorhydria is a major risk factor for Salmonella enteritidis, and several cases of severe infection have been described with this condition. After a review of the literature we conclude that patients with diminished gastric acid run an increased risk of developing Salmonella infection and often with a more serious clinical course.
Schapira
M
M
Hôpital de Jolimont, Departement of gastroenterology, Haine-Saint-Paul, Belgium.
Roquet
M E
ME
Henrion
J
J
Ghilain
J M
JM
Maisin
J M
JM
Heller
F
F
D000328:Adult; D000897:Anti-Ulcer Agents / Q000009:adverse effects*; D005750:Gastric Juice / Q000187:drug effects; D005759:Gastroenteritis / Q000209:etiology / Q000382:microbiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000009:adverse effects*; D012480:Salmonella Infections / Q000209:etiology / Q000382:microbiology*; D012477:Salmonella enteritidis
D000897:Anti-Ulcer Agents; D009853:Omeprazole