Field evaluation of doramectin for treatment of gastrointestinal nematode infections and louse infestations of cattle.
OBJECTIVE
To evaluate the safety and efficacy of doramectin given by injection at a dosage of 200 micrograms/kg of body weight for treatment of gastrointestinal nematodiasis or louse infestations of cattle.


METHODS
1,031 mixed-breed cattle were treated in the nematode study and 418 were treated in the louse study.


METHODS
Naturally parasitized cattle were given 200 micrograms of doramectin/kg or an equivalent volume of saline solution, SC. In nematode experiments, fecal samples were collected from each animal 1 week before treatment, at time of treatment, and at weekly intervals there after for 3 weeks. In louse experiments, louse counts were carried out for each animal on the day of treatment and 14 and 28 days later. All cattle were weighted at the time of treatment and at the end of the experiment.


RESULTS
By 21 days after doramectin treatment, fecal egg counts had decreased to zero in 9 of 10 experiments and to 1 egg/g in the remaining experiment. Differences between treatment groups were significant (P < 0.0001) in all instances. Pretreatment coproculture identified Haemonchus, Ostertagia, Cooperia, Trichostrongylus, and Nematrodirus as the represented genera. Doramectin was 100% effective in eliminating infestation with Linogna thus vituli, Haematopinus eurysternus, and Solenopotes capillatus. Infestation with the chewing louse Damalinia bovis was reduced overall by 86%. For all species, post treatment louse counts were significantly (P < 0.02) less for doramectin-treated cattle than for controls. Adverse reactions to doramectin were not apparent in either study.


CONCLUSIONS
Injectable doramectin at a dosage of 200 micrograms/kg is safe and effective for treatment of gastrointestinal nematodiasis and louse infestations of cattle under field conditions.
Pfizer Central Research, Grnton, CI 06340, USA.
F E
FE
Phillips
N B
NB
Logan
R M
RM
Jones
D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D006189:Haemonchus / Q000302:isolation & purification; D007279:Injections, Subcutaneous; D007306:Insecticides / Q000008:administration & dosage / Q000627:therapeutic use*; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010373:Lice Infestations / Q000188:drug therapy / Q000662:veterinary*; D009348:Nematoda / Q000302:isolation & purification; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D010028:Ostertagia / Q000302:isolation & purification; D008003:Phthiraptera; D014254:Trichostrongylus / Q000302:isolation & purification
D000871:Anthelmintics; D007306:Insecticides; D007559:Ivermectin; C084101:doramectin