Resistance to activated protein C (APC) in Indian patients of thrombophilia.
In a pilot study, 28 consecutive patients with thrombosis and 23 age and sex matched healthy normal controls were investigated with normalised APC sensitivity ratio (n-APC-SR) to know the defect exists and if so its prevalence in India. Six of the 28 (21.4%) thrombotic patients had n-APC-SR of < 0.76 (range 0.55 to 0.74) as compared to the normal control value (0.97 +/- 0.105). Our study shows APC resistance defect in a significant proportion (21.4%) of Indian patients with thrombotic disorders.
Department of Haematology, All India Institute of Medical Sciences, New Delhi.
H P
HP
Pati
A
A
Srivastava
S
S
Dayal
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D004198:Disease Susceptibility; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000378:metabolism*; D013927:Thrombosis / Q000097:blood*
D011486:Protein C