In pursuit of antisense.
The first generation of antisense oligodeoxynucleotides (ODNs) are now undergoing clinical trials, but their effects may reflect biological activities unrelated to their ability to bind RNA. Nevertheless, preclinical animal studies now suggest that phosphorothioate ODNs may be more permeable in certain animal tissues than in cell culture, raising hopes that antisense mechanisms can be exploited pharmacologically.
Matteucci
M D
MD
Gilead Sciences Inc., Foster City, California 94404, USA.
Wagner
R W
RW
D000818:Animals; D006801:Humans; D016376:Oligonucleotides, Antisense / Q000737:chemistry / Q000627:therapeutic use*; D012106:Research; D013873:Thionucleotides
D016376:Oligonucleotides, Antisense; D013873:Thionucleotides