Transient complete remission of acute lymphoblastic leukemia in relapse after allogeneic bone marrow transplantation induced by donor leukocyte transfusions.
We report the case of a young patient with refractory acute lymphoblastic leukemia relapse, after allogeneic bone marrow transplantation, who was treated by donor leukocyte infusions. We observed potent adoptive immunotherapy which produced a cytologic complete remission and total chimeric state. This was of short duration and the patient died of severe graft-versus-host disease. We present a short summary of the literature concerning acute lymphoblastic leukemia and donor leukocyte infusions.
D'Hondt
L
L
Services d'Hématologie et de Biologie Clinique, Clinique Universitaire de Mont Godinne, Belgium.
Chatelain
C
C
Doyen
C
C
Osselaer
J C
JC
Ferrant
A
A
Bosly
A
A
D000293:Adolescent; D016026:Bone Marrow Transplantation; D006801:Humans; D017708:Leukocyte Transfusion; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology / Q000628:therapy*; D012008:Recurrence; D014184:Transplantation, Homologous