Motoneuronal death without expression of NADPH-diaphorase activity after sciatic nerve cut in 5-day-old mice.
In BALB/c mice, the number of sciatic motoneurons lost was statistically insignificant whether the nerve was cut at one (P1) or five days (P5) of age. Although the motoneurons showed intense NADPH-d staining after sciatic nerve cut at P1, they were NADPH-d negative when the nerve was cut at P5. The present study casts doubt on a neurodestructive role of NO in the sciatic motoneurons after axotomy at P1.
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Department of Anatomy, Faculty of Medicine, National University of Singapore, Singapore.
Tay
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Leong
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D000367:Age Factors; D000818:Animals; D002452:Cell Count; D016923:Cell Death / Q000502:physiology; D003714:Denervation; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D009046:Motor Neurons / Q000166:cytology* / Q000201:enzymology*; D009569:Nitric Oxide / Q000502:physiology; D012584:Sciatic Nerve / Q000601:surgery*; D013116:Spinal Cord / Q000166:cytology / Q000201:enzymology
D009569:Nitric Oxide; D008058:Dihydrolipoamide Dehydrogenase