The main peritoneal source of precursors of the murine intestinal IgA plasma cell.
Previous reconstitution studies in irradiated mice distinguished B-1 from other B cells. The observation that approximately half of the B cells in the murine intestinal lamina propria are derived from peritoneal B-1 cell precursors raises the question of the derivation of their subsets (B-1a or B-1b). We examined the origin of IgA plasma cells in mice by reconstituting lethally irradiated mice with syngeneic adult bone marrow cells or fetal liver cells from syngeneic donors. We compared the level of copro IgA, the number of peritoneal B cell subsets, and differences in the IgA-positive plasma cell population in the lamina propria of the gut. The peritoneal B-1a cells were predominantly found in the fetal liver-transplanted mice rather than bone marrow-transplanted mice, but the level of copro IgA and the population of IgA plasma cells were not significantly different between two experimental groups. The results suggest that the main source of peritoneally derived B cells in the lamina propria of the gut may be B-1b cells.
Department of Anatomy, College of Veterinary Medicine, Chonnam National University, Kwangju, Korea.
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Kim
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Kim
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Han
D000818:Animals; D016175:B-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology; D005260:Female; D007070:Immunoglobulin A / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000166:cytology* / Q000276:immunology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D010950:Plasma Cells / Q000166:cytology* / Q000276:immunology
D007070:Immunoglobulin A