Abdominal zygomycotic thromboangiitis in a patient with AML and t(1;13;14).
The case report of a 61 year-old man with AML M2 FAB, t(1; 13; 14) and zygomycotic mesenterial thromboangiitis is presented. Two induction cycles of chemotherapy were administered due to primary drug resistance. They were complicated by pneumonia, colonic pseudo-obstruction and perforation with peritonitis. The patient died on the 40th day of therapy, 4 days after undergoing palliative surgery. Zygomycotic thromboangiitis, which very probably contributed to the intestinal perforation, was confirmed morphologically at necropsy. the novel complex chromosomal translocation t(1; 13; 14) (q31; q32; q24) and the problems connected with the diagnosis of invasive fungal infections are discussed.
Department of Hematology, University Hospital, Olomouc, Czech Republic.
E
E
Faber
D
D
Riegrová
M
M
Jarosová
J
J
Hubácek
P
P
Slezák
Z
Z
Pikalová
P
P
Hamal
K
K
Indrák
D000005:Abdomen; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002878:Chromosomes, Human, Pair 1; D002882:Chromosomes, Human, Pair 13; D002883:Chromosomes, Human, Pair 14; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000150:complications*; D014178:Translocation, Genetic