Aminoacyl-tRNA synthetase gene regulation in Bacillus subtilis.
In this review, we summarize progress on the regulation of the aminoacyl-tRNA synthetase genes in Bacillus subtilis. Most of the genes encoding this set of enzymes in B subtilis are members of a large family of Gram-positive genes and operons controlled by a novel antitermination mechanism that uses their cognate uncharged tRNA as the effector. A subset of these genes is, in addition, likely to be controlled at the level of mRNA processing and degradation. We describe the key experiments leading to these conclusions.
Condon
C
C
UPR 9073, Institut de Biologie Physico-Chimique, Paris, France.
Grunberg-Manago
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M
Putzer
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H
D000604:Amino Acyl-tRNA Synthetases / Q000235:genetics*; D001412:Bacillus subtilis / Q000201:enzymology* / Q000235:genetics*; D001483:Base Sequence; D002874:Chromosome Mapping; D017124:Conserved Sequence; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics*; D008969:Molecular Sequence Data; D012323:RNA Processing, Post-Transcriptional; D017421:Sequence Analysis; D014158:Transcription, Genetic / Q000235:genetics
D000604:Amino Acyl-tRNA Synthetases