Genomic instability in colorectal cancers in Turkey.
Microsatellite instability in a subset of colorectal cancers from North America, Europe and Japan has been reported. We examined 88 colorectal cancers from Turkish patients. Five different microsatellite loci (1 mono- and 4 dinucleotide repeat regions) were tested. Eight tumors displayed replication errors (RERs) with at least 2 different markers. Right-sided tumors showed significantly higher frequency of microsatellite instability compared with left-sided tumors. The frequency of RER phenotype was slightly higher in tumors occurring in younger (<50 years old) than in older patients (13% vs. 8%), and there was no association between sex and genomic instability. The frequency of genomic instability in our study group was 9%, whereas the reported frequencies in tumors from other countries varied between 12% and 16%.
Department of Molecular Oncology, Research Institute for Genetic Engineering and Biotechnology, TUBITAK, Marmara Research Center, Gebze, Turkey.
T
T
Yağci
S
S
Göksel
O
O
Doğan
M
M
Ozturk
N
N
Yurdusev
D015179:Colorectal Neoplasms / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics*; D004276:DNA, Satellite / Q000235:genetics*; D005260:Female; D015894:Genome, Human; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D014421:Turkey
D004273:DNA, Neoplasm; D004276:DNA, Satellite