Multivariate analyses of prognostic factors associated with hematopoietic recovery in autograft patients with different sources of progenitor cells. A GATMO experience. Argintine Group of Bone Marrow Transplant.
OBJECTIVE
To evaluate in a multivariate analysis the prognostic factors associated with hematopoietic recovery and the supportive care requirements after autotransplant of progenitor cells (PC) from various sources: bone marrow (BMPC), BMPC & peripheral blood (PBPC), and PBPC alone.


METHODS
A total of 570 patients with hematological malignancies and solid tumors underwent high-dose therapy followed by autotransplant. PBPC were obtained after mobilization with chemotherapy and/or cytokines. One-hundred five patients received BMPC, 217 received BMPC & PBPC and 248 PBPC alone; all of the patients received G-CSF or GM-CSF after infusion.


RESULTS
In a multivariate analysis the recovery of neutrophils was adversely associated with low numbers of nucleated cells infused (P < 0.13), bone marrow progenitor cell source, and diagnosis of multiple myeloma and acute leukemia (P < 0.001). The factors that adversely affected platelet recovery were low number of nucleated cells and diagnosis of multiple myeloma and acute leukemia (P < 0.001).


CONCLUSIONS
We conclude that BMPC adversely affect neutrophil recovery while low numbers of nucleated cells and diagnosis of multiple myeloma and acute leukemia adversely affect both neutrophil and platelet recovery.
Pavlovsky
S
S
GATMO-Grupo Argentino de Trasplante de Médula Osea, Buenos Aires, Argentina.
Koziner
B
B
Milone
G
G
Lastiri
F
F
Bayo
R
R
Fernández
I
I
Dengra
C
C
Martinez Rolón
J
J
Feldman
L
L
Kusminsky
G
G
Corrado
C
C
Bullorsky
E
E
Milone
J
J
Garcia
J J
JJ
Cerutti
I
I
Saporito
G
G
Robinson
A
A
Canepa
C
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D016026:Bone Marrow Transplantation / Q000379:methods; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D015672:Erythroid Precursor Cells; D005069:Evaluation Studies as Topic; D005260:Female; D006085:Graft Survival; D019337:Hematologic Neoplasms / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012044:Regression Analysis; D012189:Retrospective Studies; D015996:Survival Rate; D014182:Transplantation, Autologous