Success in inducing ovulation in a case of premature ovarian failure using growth hormone-releasing hormone.
Ovulation was obtained in a 29-year-old woman affected by premature ovarian failure who had previously failed to respond to two attempts performed administering human menopausal gonadotropin or follicle-stimulating hormone after the spontaneous gonadotropin production was suppressed using a gonadotropin-releasing hormone analog (buserelin). Induction of ovulation succeeded when 1000 mg/day growth hormone-releasing hormone was added to the induction scheme. Five mature follicles were obtained after 27 days therapy and the serum level of 17 beta-estradiol was 975 pg/ml (195 pg/ml per follicle) at the time of human chorionic gonadotropin administration.
Second Obstetrics and Gynecology Clinic, University of Milan, L. Mangiagalli Hospital, Italy.
M
M
Busacca
F M
FM
Fusi
C
C
Brigante
N
N
Doldi
M
M
Vignali
D000328:Adult; D004958:Estradiol / Q000097:blood / Q000378:metabolism; D005260:Female; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D010535:Laparoscopy; D010060:Ovulation / Q000187:drug effects* / Q000502:physiology; D010062:Ovulation Induction / Q000379:methods*; D016649:Primary Ovarian Insufficiency / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome
D004958:Estradiol; D013007:Growth Hormone-Releasing Hormone