Functional diversity of helper T lymphocytes.
The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal and pathological immune responses. Defining the cellular and molecular mechanisms of helper-T-cell differentiation should lead to rational strategies for manipulating immune responses for prophylaxis and therapy.
Immunology Research Division, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
A K
AK
Abbas
K M
KM
Murphy
A
A
Sher
D000818:Animals; D015551:Autoimmunity / Q000276:immunology; D002454:Cell Differentiation / Q000235:genetics; D016207:Cytokines / Q000096:biosynthesis; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007239:Infections / Q000276:immunology; D017634:Self Tolerance / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000276:immunology*
D016207:Cytokines