Design and evaluation of two-phase partition-dissolution method and its use in evaluating artemisinin tablets.
A method is described for the assessment of the dissolution behavior of solid dosage forms with a high content of a very water insoluble drug. In this method the dissolved drug is continuously extracted from the aqueous dissolution medium into an organic phase. The reported data on the dissolution of artemisinin show that this method guarantees sink conditions in the aqueous dissolution medium during the total duration of the experiment.
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Laboratory of Galenical and Clinical Pharmacy, Catholic University Leuven, Belgium.
Kinget
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D000962:Antimalarials / Q000737:chemistry*; D037621:Artemisinins; D002725:Chloroform; D012717:Sesquiterpenes / Q000032:analysis / Q000737:chemistry*; D012995:Solubility; D013607:Tablets / Q000032:analysis; D014867:Water
D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; D013607:Tablets; D014867:Water; D002725:Chloroform; C031327:artemisinin