pros-Methylimidazoleacetic acid in cerebrospinal fluid of patients with chronic schizophrenia: relationships to ratings of symptoms, ventricular brain ratios, and rates of urine excretion.
Concentrations of pros-methylimidazoleacetic acid (p-MIAA) were measured in cerebrospinal fluid of 30 patients with chronic schizophrenia. Levels of p-MIAA correlated negatively with mean scores of the Psychiatric Symptom Assessment Scale for positive symptoms (r = -0.48), but not negative symptoms, and with ventricular brain ratios (r = -0.48). Patients with abnormal ventricular enlargements had much lower concentrations of p-MIAA than those with normal ventricles. These results suggest that processes that reduce accumulation of p-MIAA in CSF may be associated with increased severity of symptoms among patients with chronic schizophrenia.
Department of Pharmacology, Mount Sinai School of Medicine, City University of New York, New York 10029-6574, USA.
G D
GD
Prell
J P
JP
Green
J K
JK
Khandelwal
R J
RJ
Wyatt
W B
WB
Lawson
A C
AC
Jaeger
C A
CA
Kaufmann
D G
DG
Kirch
D000328:Adult; D002552:Cerebral Ventricles / Q000378:metabolism*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D012559:Schizophrenia / Q000134:cerebrospinal fluid* / Q000652:urine*; D014556:Urine
D007093:Imidazoles; C002667:methylimidazoleacetic acid