Epstein-Barr virus-associated gastric carcinoma.
Epstein-Barr virus (EBV) is associated with certain types of gastric carcinoma. We report a case of EBV-positive undifferentiated carcinoma of the stomach in a 59-year-old woman with a well-demarcated ulcerating tumor in the gastric body. Examination of the resected stomach revealed that the tumor was undifferentiated carcinoma with lymphoid stroma, or lymphoepithelioma-like carcinoma. Tumor cells were positive for EBV by in situ hybridization. Gastroenterologists must keep in mind that localized ulcerating tumors of the stomach histologically seen as undifferentiated carcinnoma with lymphoid stroma are linked to EBV infection.
Department of Surgery, Saiseikai Yahata General Hospital, Kitakyushu, Japan.
Y
Y
Adachi
R
R
Yoh
J
J
Konishi
Y
Y
Iso
T
T
Matsumata
T
T
Kasai
H
H
Hashimoto
D002277:Carcinoma / Q000473:pathology / Q000601:surgery / Q000821:virology*; D005260:Female; D005743:Gastrectomy; D006566:Herpesviridae Infections; D004854:Herpesvirus 4, Human; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery / Q000821:virology*; D014412:Tumor Virus Infections