PTHrP(1-36) as a skeletal anabolic agent for the treatment of osteoporosis.
Parathyroid hormone-related protein (1-36) [(PTHrP(1-36)] has been shown to be one of the authentic secretory forms of PTHrP. Human studies employing this peptide have demonstrated that it is equipotent to parathyroid hormone (1-34). This observation, together with the observations that: (1) both peptides employ the same receptors; (2) both bind to this PTH/PTHrP receptor with equal affinity and activate the PTH/PTHrP receptor intracellular signaling pathways with the same efficacy; (3) both peptides are effective anabolic skeletal agents in laboratory animals; and (4) PTHrP is likely to be the endogenous skeletal ligand for the PTH/PTHrP receptor, collectively suggest that PTHrP (1-36) should be as equally effective as PTH(1-34) as an anabolic skeletal agent. In this mini-review, the theoretical basis for the exploration and development of PTHrP(1-36) as a potential therapeutic agent for osteoporosis is considered.
Division of Endocrinology, Connecticut VA Medical Center, West Haven, USA.
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Stewart
D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D004195:Disease Models, Animal; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy*; D010281:Parathyroid Hormone / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D044162:Parathyroid Hormone-Related Protein; D014176:Protein Biosynthesis; D011506:Proteins / Q000008:administration & dosage / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics; D014018:Tissue Distribution
C470121:PTHLH protein, human; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins