Seleno compounds and glutathione peroxidase catalyzed decomposition of S-nitrosothiols.
Seleno compounds such as selenocystamine and seleno-D, L-cystine were found to catalyze the decomposition of S-nitrosothiols (e.g. S-nitroso-glutathione and S-nitroso-N-acetyl-D, L-penicillamine) in the presence of different thiols (e.g. glutathione, N-acetyl-D-penicillamine and 2-mercaptoethanol), and liberate nitric oxide. It was also found that glutathione peroxidase itself can catalyze the decomposition of S-nitrosoglutathione without the presence of any thiol or H2O2.
Department of Chemistry, University of Miami, Coral Gables, Florida 33124, USA.
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Hou
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Guo
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Li
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Wang
D002384:Catalysis; D003538:Cystamine / Q000031:analogs & derivatives* / Q000737:chemistry; D003553:Cystine / Q000031:analogs & derivatives* / Q000737:chemistry; D005978:Glutathione / Q000031:analogs & derivatives / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D009603:Nitroso Compounds / Q000737:chemistry / Q000378:metabolism*; D016566:Organoselenium Compounds / Q000737:chemistry*; D010396:Penicillamine / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D026423:S-Nitroso-N-Acetylpenicillamine; D026422:S-Nitrosoglutathione; D013438:Sulfhydryl Compounds / Q000737:chemistry
D009603:Nitroso Compounds; D016566:Organoselenium Compounds; D013438:Sulfhydryl Compounds; C009226:selenocystine; C014807:selenocystamine; D009569:Nitric Oxide; D003553:Cystine; D026422:S-Nitrosoglutathione; D026423:S-Nitroso-N-Acetylpenicillamine; D005979:Glutathione Peroxidase; D005978:Glutathione; D010396:Penicillamine; D003538:Cystamine