Prostate-specific antigen detection by ultrasensitive assay in samples from women.
BACKGROUND
The Prostate Specific Antigen (PSA) has been characterized as a specific prostate marker. Recent studies have indicated the existence of a PSA of nonprostatic origin detected in lactating women and breast tumors.


METHODS
We have evaluated the presence of PSA by an ultrasensitive assay (COBAS CORE) in 252 serum and non serum samples from women.


RESULTS
The results demonstrate the presence of PSA in 100% of the breast secretions, 81% of the breast cysts, 80% of the bronchoalveolar lavage fluids and 71% of the cytosols of breast cancer. Likewise, PSA was detected in 14% of the sera evaluated, although the concentrations were always lower than 0.5 ng/ml.


CONCLUSIONS
We conclude that PSA should not continue being considered as the specific prostate tissue marker although, given that the serum concentrations detected are very low, they do appear to interfere to a minimum extent in the usefulness of PSA as a tumor marker.
Filella
X
X
Department of Clinical Biochemistry (Unit of Cancer Research), Hospital Clínic i Provincial, Barcelona, Spain.
Molina
R
R
Alcover
J
J
Menéndez
V
V
Giménez
N
N
Jo
J
J
Carretero
P
P
Ballesta
A M
AM
D001940:Breast / Q000378:metabolism; D001943:Breast Neoplasms / Q000737:chemistry / Q000648:ultrastructure; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D003600:Cytosol / Q000737:chemistry; D005260:Female; D005348:Fibrocystic Breast Disease / Q000737:chemistry; D006801:Humans; D007118:Immunoassay; D017430:Prostate-Specific Antigen / Q000032:analysis* / Q000097:blood; D012016:Reference Values; D012680:Sensitivity and Specificity
D017430:Prostate-Specific Antigen