The effect of linomide on the migration and the proliferation of capillary endothelial cells elicited by vascular endothelial growth factor.
In order to assess the mechanism of action of the quinoline-3-carboxyamide linomide as an antiangiogenic drug, the effect of linomide was studied in vitro on postcapillary endothelial cells exposed to vascular endothelial growth factor (VEGF). Linomide did not block the spontaneous replication of endothelial cells, but significantly suppressed endothelial cell growth and migration elicited by VEGF. It is concluded that linomide appears to be an effective tool to inhibit VEGF-dependent angiogenesis.
Parenti
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Department of Pharmacology, University of Florence, Italy.
Donnini
S
S
Morbidelli
L
L
Granger
H J
HJ
Ziche
M
M
D002196:Capillaries / Q000166:cytology / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects*; D016228:Endothelial Growth Factors / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D006912:Hydroxyquinolines / Q000494:pharmacology*; D009389:Neovascularization, Pathologic / Q000517:prevention & control
D016228:Endothelial Growth Factors; D006912:Hydroxyquinolines; C045282:roquinimex