Linkage disequilibrium studies in the thyroid peroxidase and apolipoprotein B genes.
Linkage disequilibria in the apolipoprotein B (APOB) gene (EcoRI RFLP/3' APOB VNTR) and in the thyroid peroxidase (TPO) gene (AcyI RFLP/TPO VNTR) were investigated in a sample of 100 individuals from southern Italy. By recoding multiallelic data as diallelic data, each RFLP-VNTR system showed linkage disequilibrium significantly different from zero (EcoRI RFLP/3' APOB VNTR: p < 0.001; AcyI RFLP/TPO VNTR: p < 0.025), thus suggesting that the VNTR arrays are stable. Furthermore, the relationship between the 3' APOB (2p24-p23) and TPO (2pter-p24) VNTR multiallelic systems was also analyzed. The two VNTR polymorphisms were found to be in linkage equilibrium, thus indicating that they can be used together in forensic casework.
De Benedictis
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Department of Cell Biology, University of Calabria, Rende, Italy.
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D001055:Apolipoproteins B / Q000235:genetics*; D016172:DNA Fingerprinting; D005787:Gene Frequency; D006801:Humans; D007453:Iodide Peroxidase / Q000235:genetics*; D007558:Italy; D015810:Linkage Disequilibrium / Q000235:genetics*; D018598:Minisatellite Repeats / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012494:Sampling Studies
D001055:Apolipoproteins B; D007453:Iodide Peroxidase