Protective effects of GSH, vitamin E, and selenium on lipid peroxidation in cadmium-fed rats.
Increased intake of Cd results in its retention and in peroxidative damage in soft tissues. Coadministration of antioxidants, viz., glutathione (GSH), alpha-tocopherol, and Se, restricted the uptake and distribution of Cd in liver and kidney of rats. Moreover, no rise in malondialdehyde was recorded. Although possible antioxidative mechanisms manifested by GSH, alpha-tocopherol, and Se have been discussed, it is hypothesized that GSH functions as a Cd chelator. Glutathione yielded favorable effects in comparison to Se and alpha-tocopherol.
Rana
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Department of Zoology, Ch. Charan Singh University, Meerut, India.
Verma
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D000818:Animals; D000931:Antidotes / Q000008:administration & dosage / Q000494:pharmacology*; D002104:Cadmium / Q000008:administration & dosage / Q000633:toxicity*; D002614:Chelating Agents / Q000008:administration & dosage / Q000494:pharmacology*; D005527:Food, Fortified; D005978:Glutathione / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D019803:Glutathione Disulfide; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D018038:Sodium Selenite / Q000008:administration & dosage / Q000494:pharmacology*; D014018:Tissue Distribution; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
D000931:Antidotes; D002614:Chelating Agents; D002104:Cadmium; D014810:Vitamin E; D005978:Glutathione; D018038:Sodium Selenite; D019803:Glutathione Disulfide