Development of an antivenom against toxins of Lonomia obliqua caterpillars.
Skin contact with caterpillars of Lonomia moths causes haemostatic disorders that may evolve into a haemorrhagic syndrome. Replacement therapy has been shown to exacerbate the clinical symptoms of this envenoming. In this study it is shown that horses immunized with a bristle extract of L. obliqua caterpillars produced IgG antibodies that completely neutralized, in vitro, the toxin(s) responsible for the blood incoagulability observed in rats. This antivenom offers the possibility of specific treatment for envenoming caused by contact with caterpillars of Lonomia moths.
Laboratory of Immunochemistry, Instituto Butantan, SP, Brazil.
W D
WD
Da Silva
C M
CM
Campos
L R
LR
Gonçalves
M C
MC
Sousa-e-Silva
H G
HG
Higashi
I K
IK
Yamagushi
E M
EM
Kelen
D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D000997:Antivenins / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D001180:Arthropod Venoms; D001777:Blood Coagulation / Q000187:drug effects; D015195:Drug Design; D006470:Hemorrhage / Q000188:drug therapy / Q000517:prevention & control; D006487:Hemostasis; D006736:Horses; D007074:Immunoglobulin G / Q000378:metabolism; D007150:Immunohistochemistry; D009036:Moths; D051381:Rats; D014611:Vaccination
D000997:Antivenins; D001180:Arthropod Venoms; D007074:Immunoglobulin G