Guanine nucleotide exchange factors for the Rho GTPases: a role in human disease?
The Rho family of low molecular weight GTP-binding proteins control important aspects of cell shape, adhesion, movement and growth. The DBL-homology (DH) protein family of upstream regulators of Rho GTPases has recently been identified, and deregulated expression of these proteins can have dramatic cellular consequences. This review examines the possible role of DH proteins and Rho GTPases in oncogenesis, metastasis and development.
Olson
M F
MF
Institute of Cancer Research, Chester Beatty Laboratories, London, UK.
D000818:Animals; D019204:GTP-Binding Proteins / Q000502:physiology*; D020662:Guanine Nucleotide Exchange Factors; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms; D015513:Oncogene Proteins / Q000502:physiology; D011505:Protein-Tyrosine Kinases; D011506:Proteins / Q000378:metabolism / Q000502:physiology*; D011518:Proto-Oncogene Proteins; D051562:Proto-Oncogene Proteins c-bcr; D015682:Retroviridae Proteins, Oncogenic / Q000502:physiology; D000075684:T-Lymphoma Invasion and Metastasis-inducing Protein 1; D020741:rho GTP-Binding Proteins
C490796:FGD1 protein, human; D020662:Guanine Nucleotide Exchange Factors; C057811:MCF2 protein, human; D015513:Oncogene Proteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; D015682:Retroviridae Proteins, Oncogenic; D000075684:T-Lymphoma Invasion and Metastasis-inducing Protein 1; C087334:TIAM1 protein, human; D011505:Protein-Tyrosine Kinases; C496613:BCR protein, human; D051562:Proto-Oncogene Proteins c-bcr; D019204:GTP-Binding Proteins; D020741:rho GTP-Binding Proteins