Zinc supplementation during pregnancy: a double blind randomised controlled trial.
OBJECTIVE
To investigate whether zinc supplementation during pregnancy improves maternal and fetal outcome.


METHODS
Controlled clinical trial started at registration until discharge of mother and child from hospital. Two thousand volunteer mothers were randomly assigned to receive zinc supplementation or placebo in a double blind trial.


METHODS
Women less than 20 weeks pregnant at the first visit who agreed to take part in the study. One thousand two hundred and six mothers were available for study.


METHODS
Volunteers were randomly selected to receive two tablets of zinc (44 mg zinc in total) or two placebo tablets containing inert substances, indistinguishable in appearance and taste from the zinc tablets.


METHODS
Large for gestational age (LGA), small for gestational age (SGA), premature rupture of the membrane (PROM), preterm labor (PL), preeclampsia and bleeding in the second or third trimester.


RESULTS
There were no differences between mothers given zinc supplementation concerning the outcome parameters and those given placebo.


CONCLUSIONS
Zinc supplementation in pregnancy in a normal healthy middle class population in Denmark does not seem to offer any benefits to the mother or her fetus.
Department of Obstetrics and Gynaecology, Kolding Hospital, Denmark.
B
B
Jønsson
B
B
Hauge
M F
MF
Larsen
F
F
Hald
D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D013607:Tablets; D015032:Zinc / Q000008:administration & dosage*
D013607:Tablets; D015032:Zinc