Cellulose acetate trimellitate ethylcellulose blends for non-steroidal anti-inflammatory drug (NSAID) microspheres.
Ketoprofen (Ket), a non-steroidal anti-inflammatory drug, has been incorporated into polymeric micromatrices (microspheres) prepared by a spray drying process and made of cellulose acetate trimellitate (CAT)/ethylcellulose (EC) blends. Drug loaded microspheres were obtained by spray-drying organic solutions of the two polymers and the drug. Characterization of the microparticles (morphology, particle size distribution, drug content, yield of production, surface properties, solvent residues) was carried out and in-vitro release behaviour measured. The release rate of the drug diminished as the proportion of EC was raised.
Giunchedi
P
P
Department of Pharmaceutical Chemistry, University of Pavia, Italy.
Torre
M L
ML
Maggi
L
L
Conti
B
B
Conte
U
U
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism; D001672:Biocompatible Materials / Q000378:metabolism; D002214:Capsules / Q000737:chemistry / Q000378:metabolism; D002482:Cellulose / Q000031:analogs & derivatives* / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism; D004339:Drug Compounding; D006863:Hydrogen-Ion Concentration; D007660:Ketoprofen / Q000378:metabolism*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D012997:Solvents / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001672:Biocompatible Materials; D002214:Capsules; D004337:Drug Carriers; D012997:Solvents; C005062:acetylcellulose; C013517:ethyl cellulose; D002482:Cellulose; D007660:Ketoprofen