Effects in vitro of pachymatismin, a glycoprotein from the marine sponge Pachymatisma johnstonii, on a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6).
Pachymatismin is a new cytostatic factor extracted from the marine sponge Pachymatisma johnstonii Bowerbank 1842 (Demospongiae, Geodiidae), which has an antiproliferative effect in vitro on cells from a human non-small-cell bronchopulmonary carcinoma (NSCLC-N6). The substance, both administered as a continuous and discontinuous treatment, triggers the irreversible arrest of cells in the G0/G1 phase of the cell cycle and morphological changes, thereby causing their destruction. Taken all together, these observations suggest that pachymatismin would induce atypical terminal cellular differentiation.
Laboratoire de Pharmacologie Marine, Faculté de Pharmacie, Nantes, France.
M
M
Zidane
P
P
Pondaven
C
C
Roussakis
M T
MT
More
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001685:Biological Factors / Q000494:pharmacology*; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology; D002453:Cell Cycle / Q000187:drug effects / Q000235:genetics; D004354:Drug Screening Assays, Antitumor; D006023:Glycoproteins / Q000494:pharmacology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008175:Lung Neoplasms / Q000473:pathology; D011161:Porifera / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000473:pathology
D000970:Antineoplastic Agents; D001685:Biological Factors; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; C106743:pachymatismin protein, Pachymatisma johnstonii