Chronic administration of 1-benzyl-1,2,3,4-tetrahydroisoquinoline, an endogenous amine in the brain, induces parkinsonism in a primate.
1-Benzyl-1,2,3,4-tetrahydroisoquinoline hydrochloride (1Bn TIQHCl) (22 mg/kg per day) was subcutaneously injected into a monkey, Macaca fascicularis for 66 days to investigate its acute and chronic effects Parkinsonism like motor symptoms appeared, and the acute toxicity was stronger than the chronic toxicity. This result suggested that 1BnTIQ may induce parkinsonism in humans. 1BnTIQ content in various regions of the monkey brain was determine by the gas chromatography-selected ion-monitoring method, but no significant variation was found.
Kotake
Y
Y
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Yoshida
M
M
Ogawa
M
M
Tasaki
Y
Y
Hirobe
M
M
Ohta
S
S
D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D007279:Injections, Subcutaneous; D007546:Isoquinolines / Q000633:toxicity*; D008252:Macaca fascicularis; D008297:Male; D009498:Neurotoxins / Q000633:toxicity*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced*; D044005:Tetrahydroisoquinolines; D013997:Time Factors
D007546:Isoquinolines; D009498:Neurotoxins; D044005:Tetrahydroisoquinolines; C084924:1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline