alpha-Ketoglutarate application in hemodialysis patients improves amino acid metabolism.
In hemodialysis patients, free amino acids and alpha-ketoacids in plasma were determined by fluorescence HPLC to assess the effect of alpha-ketoglutarate administration in combination with the phosphate binder calcium carbonate on the amino acid metabolism. During 1 year of therapy in parallel to inorganic phosphate, urea in plasma decreased significantly, histidine, arginine and proline as well as branched chain alpha-ketoacids, in particular alpha-ketoisocaproate, a regulator of protein metabolism, increased. Thus, administration of alpha-ketoglutarate with calcium carbonate effectively improves amino acid metabolism in hemodialysis patients as it decreases hyperphosphatemia.
Riedel
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Freie Universität Berlin, Institut für Biochemie, Deutschland.
Nündel
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Hampl
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D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000097:blood / Q000378:metabolism*; D002119:Calcium Carbonate / Q000627:therapeutic use*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005921:Glomerulonephritis / Q000097:blood / Q000628:therapy; D006801:Humans; D007656:Ketoglutaric Acids / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000097:blood / Q000628:therapy; D009748:Nutrition Disorders / Q000209:etiology / Q000517:prevention & control; D010710:Phosphates / Q000097:blood; D007690:Polycystic Kidney Diseases / Q000097:blood / Q000628:therapy; D006435:Renal Dialysis; D013997:Time Factors; D014508:Urea / Q000097:blood
D000596:Amino Acids; D007656:Ketoglutaric Acids; D010710:Phosphates; D014508:Urea; D002119:Calcium Carbonate