Relapsing hemorrhagic varicella.
A 15 year old boy with a past history of chickenpox in infancy was complicated by lethal varicella during the course of chemotherapy against recurrent acute myeloblastic leukemia. He had received allo-bone marrow transplantation and had overcome a graft-versus-host disease. The skin eruptions were hemorrhagic and progressive during the last 3 weeks, with numerous intranuclear inclusions histologically confirmed in the involved epidermis, hair follicles and endothelial cells. Immunohistochemical and electron microscopic studies confirmed the infection of varicella-zoster virus.
Suwabe
H
H
Department of Pathology, Tokai University School of Medicine, Isehara, Japan.
Yabe
H
H
Tsutsumi
Y
Y
D000293:Adolescent; D002644:Chickenpox / Q000139:chemically induced* / Q000473:pathology*; D064420:Drug-Related Side Effects and Adverse Reactions; D017809:Fatal Outcome; D006470:Hemorrhage / Q000473:pathology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008297:Male; D012008:Recurrence