Trust, The fragile foundation of contemporary biomedical research.
It is widely assumed that informing prospective subjects about the risks and possible benefits of research not only protects their rights as autonomous decisionmakers, but also empowers them to protect their own interests. Yet interviews with patient-subjects conducted under the auspices of the Advisory Committee on Human Radiation Experiments suggest this is not always the case. Patient-subjects often trust their physician to guide them through decisions on research participation. Clinicians, investigators, and IRBs must assure that such trust is not misplaced.
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NE
Kass
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J
Sugarman
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R
Faden
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M
Schoch-Spana
D026683:Advisory Committees; D002986:Clinical Trials as Topic; D032882:Comprehension; D032962:Consent Forms; D030881:Disclosure; D036262:Empirical Research; D028744:Ethics Committees, Research; D006801:Humans; D009042:Motivation; D026706:Paternalism; D010358:Patient Participation; D010817:Physician-Patient Relations; D012106:Research; D035842:Research Subjects; D035844:Researcher-Subject Relations; D018570:Risk Assessment; D036302:Therapeutic Human Experimentation; D035703:Therapies, Investigational; D035502:Trust; D014342:Truth Disclosure