Synaptogenesis and dendritic growth in the cortex opposite unilateral sensorimotor cortex damage in adult rats: a quantitative electron microscopic examination.
Unilateral lesions of the forelimb area of the sensorimotor cortex in adult rats resulted in time-dependent increases in the number of synapses per neuron and the volume and membrane surface area of dendritic processes per neuron within layer V of the contralateral motor cortex in comparison to sham-operated rats. Based on previous findings of a behavioral relationship with increased dendritic arborization, these changes may be related to lesion-induced compensatory changes in the use of the non-impaired (ipsilateral to the lesion) forelimb.
Jones
T A
TA
Beckman Institute, University of Illinois, Urbana 61801, USA. tajones@u.washington.edu
Kleim
J A
JA
Greenough
W T
WT
D000367:Age Factors; D000818:Animals; D003213:Conditioning, Psychological / Q000502:physiology; D003712:Dendrites / Q000502:physiology* / Q000648:ultrastructure; D005552:Forelimb / Q000294:innervation; D008297:Male; D008854:Microscopy, Electron; D008867:Microtomy; D009044:Motor Cortex / Q000473:pathology*; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000502:physiology / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D013003:Somatosensory Cortex / Q000473:pathology*; D013569:Synapses / Q000502:physiology* / Q000648:ultrastructure