Inhibition of human cytochrome P450-3A isoforms by fluoxetine and norfluoxetine: in vitro and in vivo studies.
Greenblatt
D J
DJ
Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA.
von Moltke
L L
LL
Schmider
J
J
Harmatz
J S
JS
Shader
R I
RI
D001189:Aryl Hydrocarbon Hydroxylases; D051544:Cytochrome P-450 CYP3A; D065607:Cytochrome P-450 Enzyme Inhibitors; D004347:Drug Interactions; D005473:Fluoxetine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D010089:Oxidoreductases, N-Demethylating / Q000037:antagonists & inhibitors*; D010599:Pharmacokinetics; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*
D001189:Aryl Hydrocarbon Hydroxylases; D051544:Cytochrome P-450 CYP3A; D065607:Cytochrome P-450 Enzyme Inhibitors; D005473:Fluoxetine; D007527:Isoenzymes; D010089:Oxidoreductases, N-Demethylating; D017367:Selective Serotonin Reuptake Inhibitors; C036139:norfluoxetine