Rôle of bile in the elimination of dipropyl sulphone from the male rat.
Following oral administration of [35S]-dipropyl sulphone to male Wistar rats (4.24 mmol/kg body wt), the only radioactive component subsequently found in the blood and bile was the sulphone. Biliary excretion played an important rôle in the elimination of this compound, with 16% of the dose excreted during the first twenty-four hours and 33% passing through the bile duct over a two day period. Bile/plasma concentration ratios remained constant during the first day (c. 46-fold), suggesting that a concentration process was taking place and that active transport of this low molecular weight compound (150 Da) into the bile was occurring.
Imperial College School of Medicine at St. Mary's, London, UK.
R M
RM
Nickson
S C
SC
Mitchell
D000818:Animals; D001646:Bile / Q000378:metabolism*; D008297:Male; D008970:Molecular Weight; D051381:Rats; D017208:Rats, Wistar; D013055:Spectrophotometry, Infrared; D013450:Sulfones / Q000378:metabolism*; D013462:Sulfur Radioisotopes
D013450:Sulfones; D013462:Sulfur Radioisotopes; C099075:dipropyl sulfone