Evaluation of new putative tumor markers for melanoma.
BACKGROUND
The early diagnosis of recurrent melanoma can contribute to better outcome if the disease can be surgically resected or if the metastases are responsive to systemic therapies. Lipid-associated sialic acid (LASA-P) and the S-100 protein (S-100) were evaluated as tumor markers for melanoma with the goal of early detection of recurrence.


METHODS
Sixty-seven patients were identified who had levels of S-100 and LASA-P drawn during their clinical course. A multivariate regression analysis was performed to determine the significance of the serum markers in relation to other prognostic factors for melanoma.


RESULTS
After a median follow-up of 30 months, 58 patients had recurrences, and 49 patients died of disease. LASA-P elevation was not associated with the time to recurrence (p = 0.2176) or survival (p = 0.2507). S-100 positivity was a significant predictor of recurrence (p < 0.0001) and survival (p = 0.0059). The median time to recurrence for S-100-positive and S-100-negative patients was 7.6 and 33.8 months, respectively. The median survival time was 59.2 months for S-100-negative patients and 29.6 months for patients positive for S-100.


CONCLUSIONS
Serum S-100 shows significant correlations to both time to recurrence and survival and could be useful in the clinical detection of malignant melanoma.
Miliotes
G
G
Division of Medical Oncology, Moffitt Cancer Center and Research Institute, University of South Florida, Tampa 33612-9497, USA.
Lyman
G H
GH
Cruse
C W
CW
Puleo
C
C
Albertini
P A
PA
Rapaport
D
D
Glass
F
F
Fenske
N
N
Soriano
T
T
Cuny
C
C
Van Voorhis
N
N
Reintgen
D
D
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008545:Melanoma / Q000175:diagnosis* / Q000401:mortality; D008875:Middle Aged; D015999:Multivariate Analysis; D019158:N-Acetylneuraminic Acid / Q000097:blood*; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D009418:S100 Proteins / Q000097:blood*; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000401:mortality; D015996:Survival Rate
D014408:Biomarkers, Tumor; D008055:Lipids; D009418:S100 Proteins; C054080:lipid-associated sialic acid; D019158:N-Acetylneuraminic Acid