Familial presumed cerebral cavernous angiomas diagnosed by MRI: three generations.
Familial cerebral cavernous angiomas are rare, with an autosomal dominant pattern of inheritance. To our knowledge, 25 families with this disorder have been described. We report three family members in a direct line of descent, who all brain had lesions typical of cavernous angiomas on MRI.
Mori
T
T
Department of Neurosurgery, Saiseikai Shigaken Hospital, Ohashi, Shiga, Japan.
Fujimoto
M
M
Sakae
K
K
Shimada
K
K
Shin
H
H
Sakakibara
T
T
Yamaki
T
T
Ueda
S
S
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000235:genetics; D002648:Child; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D005799:Genes, Dominant / Q000235:genetics; D006392:Hemangioma, Cavernous / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000235:genetics; D009460:Neurologic Examination; D010375:Pedigree; D010641:Phenotype