Long-term follow-up of ocular findings in children with Stickler's syndrome.
OBJECTIVE
To document the longitudinal changes in eye status of children diagnosed with Stickler's syndrome in the first decade of life.


METHODS
All patients with cleft palate were referred for eye examination. Of these, patients with systemic findings of Stickler's syndrome were included in this report.


RESULTS
Thirty-four eyes in 17 patients met inclusion criteria, with median best-corrected recognition acuity of 20/30. The mean cycloplegic refraction at presentation was -5.00 diopters, and the mean refraction at last visit was -5.50 diopters.


CONCLUSIONS
Refractive errors, cataracts, and vitreoretinal abnormalities can be detected early in life in patients with Stickler's syndrome, and refractive error changed little during the follow-up period.
Division of Ophthalmology, Children's Hospital of Philadelphia, PA 19104-4399, USA.
M C
MC
Wilson
D M
DM
McDonald-McGinn
G E
GE
Quinn
G D
GD
Markowitz
D
D
LaRossa
A D
AD
Pacuraru
X
X
Zhu
E H
EH
Zackai
D002386:Cataract / Q000175:diagnosis; D002675:Child, Preschool; D002972:Cleft Palate / Q000175:diagnosis; D005128:Eye Diseases / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009216:Myopia / Q000175:diagnosis*; D010003:Osteoarthritis / Q000175:diagnosis*; D012029:Refraction, Ocular; D012030:Refractive Errors / Q000175:diagnosis / Q000503:physiopathology; D012164:Retinal Diseases / Q000175:diagnosis; D013577:Syndrome; D014792:Visual Acuity; D014822:Vitreous Body / Q000473:pathology