Ki-1 anaplastic large cell lymphoma with a prominent leukemic phase.
Patients with Ki-1 (CD30)-positive anaplastic large cell lymphoma (ALCL) occasionally have rare circulating lymphoma cells. We report a case of ALCL with a prominent leukemic phase. A 36-year-old man presented with widespread ALCL involving lymph nodes, spleen, pleural fluid, cerebrospinal fluid, and bone marrow. His white blood cell count was 106,000/mm3 with 20% lymphoma cells. The circulating neoplastic cells were large, and had irregular nuclei with multiple small nucleoli, ample cytoplasm, and multiple clear cytoplasmic vacuoles. This case illustrates that ALCL may have a marked leukemic phase composed of large anaplastic cells.
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109-06021, USA.
M M
MM
Anderson
C W
CW
Ross
T P
TP
Singleton
S
S
Sheldon
B
B
Schnitzer
D000328:Adult; D006801:Humans; D007945:Leukemia, Lymphoid / Q000473:pathology*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000473:pathology*; D008297:Male