Uterine leiomyosarcoma with osteoclast-like giant cells: histopathological and cytological observations.
A 56 year old woman presented with abnormal uterine bleeding. Except for a myomatous uterus, no other abnormalities were noted on physical examination and in radiographic and serologic studies. The hysterectomy specimen revealed an 8 cm uterine fundic tumor composed of two histologically different patterns that merged with one another; one was a well differentiated leiomyosarcoma and the other a mixture of osteoclast-like giant cells (OGC) and plump spindle cells whose cell borders blended, resembling the histology of giant cell tumor of bone. Immunohistochemical studies showed positive staining for muscle actin, alpha-smooth muscle actin, and KP-1 (CD68) in both the spindle cells and OGC. The latter also stained for alpha-1-antitrypsin and alpha-1-antichymotrypsin. These findings suggested that OGC may be formed by the fusion of spindle cells of leiomyosarcoma and also express histiocytic markers.
Watanabe
K
K
Department of Pathology, Fukushima Medical College, Jusendoh General Hospital, Japan.
Hiraki
H
H
Ohishi
M
M
Mashiko
K
K
Saginoya
H
H
Suzuki
T
T
D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007890:Leiomyosarcoma / Q000473:pathology*; D008875:Middle Aged; D010010:Osteoclasts / Q000473:pathology; D014594:Uterine Neoplasms / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
D014746:Vimentin