[Glucose transporter].
All mammalian cells contain trans-membrane transport systems for the stereo specific uptake of glucose. These systems are divided into two groups, a facilitated diffusion system driven by the concentration differences across the membrane and an energy-dependent, active transport system. Both are mediated by specific membrane proteins, termed glucose transporter. The facilitated glucose transporters comprise a structurally related family of proteins having 12 membrane-spanning domains, with the amino terminus, a relatively large middle loop and the carboxy-terminus all oriented towards the cytoplasm. The active glucose transport system is also designated Na+/glucose cotransporter, SGLT, the predicted secondary structure of which is still controversial.
Third Department of Internal Medicine, Yamaguchi University School of Medicine, Japan.
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Oka
D000818:Animals; D001692:Biological Transport; D004058:Diffusion; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007328:Insulin; D017136:Ion Transport; D009004:Monosaccharide Transport Proteins / Q000502:physiology; D015398:Signal Transduction; D012964:Sodium / Q000378:metabolism; D013572:Synaptic Vesicles / Q000378:metabolism
D007328:Insulin; D009004:Monosaccharide Transport Proteins; D012964:Sodium; D005947:Glucose