Serum alpha 1-antitrypsin concentration in dogs with panniculitis.
OBJECTIVE
To measure serum alpha 1-antitrypsin (alpha 1AT) concentration in dogs with histologically confirmed panniculitis to determine whether serum deficiency could cause or exacerbate panniculitis in dogs.


METHODS
Cross-sectional, descriptive study.


METHODS
9 dogs (5 with multiple lesions and 4 with solitary lesions).


METHODS
Serum samples were obtained by means of cephalic or jugular venipuncture and frozen at -20 C until assayed. Serum alpha 1AT concentration was measured by means of radial gel immunodiffusion.


RESULTS
In all dogs, serum alpha 1AT concentration was within the previously established reference range.


CONCLUSIONS
In the small number of-dogs studied, panniculitis was not associated with serum alpha 1AT deficiency.
Center for Veterinary Critical Care, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104-6010, USA.
D
D
Hughes
M H
MH
Goldschmidt
R J
RJ
Washabau
F
F
Kueppers
D000273:Adipose Tissue / Q000473:pathology; D000818:Animals; D003430:Cross-Sectional Studies; D004283:Dog Diseases / Q000097:blood* / Q000209:etiology / Q000473:pathology; D004285:Dogs; D005260:Female; D008297:Male; D015434:Panniculitis / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D000515:alpha 1-Antitrypsin / Q000032:analysis*; D019896:alpha 1-Antitrypsin Deficiency
D000515:alpha 1-Antitrypsin