Rapidly progressive pulmonary artery hypertension and end-stage liver disease.
Pulmonary hypertension is a recognized but unusual complication of liver disease. It can complicate the perioperative course of liver transplantation. Mild to moderate pulmonary hypertension is generally well tolerated during the procedure and does not appear to contribute to mortality. Since the pulmonary vascular disease may progress rapidly, it may have advanced to the point of irreversibility at the time of surgery. So, patients with known moderate pulmonary hypertension should have pulmonary arterial catheterisation immediately prior to transplantation. If pulmonary artery hypertension has become severe, then a preoperative trial of vasodilators is warranted. If this fails, the procedure should be cancelled. We present a patient with alcoholic liver cirrhosis in whom a rapidly progressive pulmonary hypertension made liver transplantation impossible.
Department of Anaesthesiology, University Hospital of Ghent, Belgium.
E
E
Mortier
M
M
Ongenae
J
J
Poelaert
N
N
Den Blauwen
J
J
Decruyenaere
J
J
Van Aken
G
G
Rolly
D000328:Adult; D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology*; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications*; D016031:Liver Transplantation; D008297:Male; D011651:Pulmonary Artery / Q000503:physiopathology