Health risk assessment for inuit newborns exposed to dioxin-like compounds through breast feeding.
Inuit people living in the Arctic receive an unusually high dose of dioxin-like compounds through their traditional diet, which comprises large amounts of fatty tissues from various sea mammal species. During breast feeding, the mother transfers part of their body burden to its newborn. We estimated the impact of breast feeding on the body burden of Inuit from birth to age 75 years. Simulations performed with a toxicokinetic model revealed that breast feeding strongly influences body burden during childhood but not after age 20 years. Liver and adipose tissue concentrations expected in Inuit are well below those which induced severe adverse health effects in laboratory animals, e.g. cancer and reproduction. However, these concentrations approach levels generating subtle effects on reproductive systems.
Ayotte
P
P
Departement de Medecine sociale et preventive, Faculte de Medecine, Universite Laval, Ste-Foy, Canada.
Carrier
G
G
Dewailly
E
E
D000273:Adipose Tissue / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism; D001572:Benzofurans / Q000493:pharmacokinetics / Q000633:toxicity*; D001822:Body Burden; D001942:Breast Feeding; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D004930:Inuit; D008099:Liver / Q000378:metabolism; D008875:Middle Aged; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000633:toxicity; D011108:Polymers / Q000493:pharmacokinetics / Q000633:toxicity; D012307:Risk Factors
D001572:Benzofurans; D000072317:Polychlorinated Dibenzodioxins; D011108:Polymers; C016068:polychlorodibenzofuran