Histopathology of idiopathic chronic recurrent vertigo.
Vestibular neuritis is a degenerative neuropathy of the peripheral vestibular system. The etiology of this condition is uncertain, although it is generally believed to be viral. A small percentage of patients with vestibular neuritis have chronic recurrent episodes of vertigo. Detailed cytologic descriptions of acute or chronic vestibular neuritis are lacking, and no previous studies have reported evidence of chronic inflammation in human temporal bone specimens. The authors of this study examined temporal bone specimens from three patients with a history of chronic recurrent vertigo of unknown cause. Varying degrees of inflammation and destruction were seen in the vestibular system, and mild involvement of the cochlear system was noted. These findings are consistent with postinfectious inflammatory changes of the cochlear-vestibular system analogous to a postinfectious syndrome involving the central nervous system.
Division of Otolaryngology--Head and Neck Surgery, Victor Goodhill Ear Center, University of California, Los Angeles School of Medicine, USA.
A
A
Ishiyama
G P
GP
Ishiyama
I
I
Lopez
L R
LR
Eversole
V
V
Honrubia
R W
RW
Baloh
D003056:Cochlear Nerve / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009411:Nerve Endings / Q000473:pathology; D009443:Neuritis / Q000150:complications / Q000473:pathology*; D012008:Recurrence; D014717:Vertigo / Q000209:etiology / Q000473:pathology*; D014725:Vestibular Nerve / Q000473:pathology*; D000160:Vestibulocochlear Nerve Diseases / Q000150:complications / Q000473:pathology