Chemical mechanisms of formation of DNA-carcinogen adducts, elucidation of potential of adducts for mutagenicity, and mechanisms of polymerase fidelity and mutation in the presence of adducts.
Guengerich
F P
FP
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville TN 37232-0146, USA.
Kim
M S
MS
Müller
M
M
Lowe
L G
LG
D016604:Aflatoxin B1 / Q000633:toxicity; D000818:Animals; D001483:Base Sequence; D002273:Carcinogens; D002471:Cell Transformation, Neoplastic; D018736:DNA Adducts; D004257:DNA Polymerase II / Q000378:metabolism; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D016296:Mutagenesis; D013379:Substrate Specificity
D002273:Carcinogens; D018736:DNA Adducts; D016604:Aflatoxin B1; D004257:DNA Polymerase II; D004259:DNA-Directed DNA Polymerase