Kinetics of n-butyl alcohol and m-xylene in blood during single and combined inhalation exposure in rats.
The levels of m-xylene and n-butyl alcohol in blood of rats during single and combined inhalation exposure to m-xylene and n-butyl alcohol at the concentrations of 100 + 100 ppm were investigated. We found that levels of n-butyl alcohol and m-xylene in blood of animals during single exposure did not differ as compared to coexposure. It has been shown that less than additive neurotoxic and irritating respiratory tract effects of m-xylene and n-butyl alcohol mixture, observed earlier under acute and subchronic inhalation study, cannot be explained by their metabolic interaction.
Department of Toxicology Evaluation, The Nofer Institute of Occupational Medicine, Lodz, Poland.
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R
Swiercz
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Z
Korsak
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K
Rydzynski
D020001:1-Butanol; D000280:Administration, Inhalation; D000704:Analysis of Variance; D000818:Animals; D000440:Butanols / Q000097:blood* / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014992:Xylenes / Q000097:blood* / Q000493:pharmacokinetics
D000440:Butanols; D014992:Xylenes; D020001:1-Butanol; C031285:3-xylene