Decreased neurotrophin-3 expression in skeletal muscles of streptozotocin-induced diabetic rats.
The expression of neurotrophin-3 (NT-3) in skeletal muscles was measured in rats with streptozotocin (STZ)-induced diabetes using Northern blot analysis. At 6 weeks after STZ induction of diabetes, the NT-3 mRNA level in the quadriceps and gastrocnemius muscles was decreased by 45 and 77%, respectively, compared with that in age-matched controls. Since NT-3 is considered to be essential for the maintenance of spinal proprioceptive afferent neurons, decreased NT-3 expression in target tissues would impair the integrity of afferent neurons and might be an earlier marker in the sensory neuronal damage observed in diabetes mellitus.
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan.
C
C
Ihara
A
A
Shimatsu
H
H
Mizuta
H
H
Murabe
Y
Y
Nakamura
K
K
Nakao
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D015536:Down-Regulation; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism*; D009414:Nerve Growth Factors / Q000096:biosynthesis*; D020933:Neurotrophin 3; D051381:Rats; D017208:Rats, Wistar; D015854:Up-Regulation
D009414:Nerve Growth Factors; D020933:Neurotrophin 3