The effect of propofol on the neutrophil respiratory burst.
We have examined the effect of propofol on the neutrophil respiratory burst. Chemiluminescence was used as a measure of the respiratory burst following stimulation with 10(-5) M N-formyl-L-methionyl-L-leucyl-L-phenylalanine. Propofol 1.25, 2.5 and 5.0 x 10(-5) M inhibited neutrophil chemiluminescence by 29.6, 43.0 and 57.6%, respectively, in neutrophils prepared from healthy adult volunteers, and by 25.5, 37.4 and 54.7% in cells from patients with severe sepsis. We conclude that propofol interferes with the ability of human neutrophils to generate reactive oxygen species.
Murphy
P G
PG
Department of Anaesthesia, General Infirmary at Leeds, UK.
Ogilvy
A J
AJ
Whiteley
S M
SM
D000328:Adult; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology; D006801:Humans; D008163:Luminescent Measurements; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D015742:Propofol / Q000494:pharmacology*; D016897:Respiratory Burst / Q000187:drug effects*; D018805:Sepsis / Q000378:metabolism
D018686:Anesthetics, Intravenous; D005217:Fat Emulsions, Intravenous; D009240:N-Formylmethionine Leucyl-Phenylalanine; D015742:Propofol