Histiocytic necrotizing lymphadenitis (Kikuchi's disease).
We present a case report of a young asiatic women presenting Kikuchi's lymphadenitis, a suprahyoidea mass, pharyngitis, fever, weakness and lack of appetite. The clinical picture quickly improved after biopsy until complete remission within two months. Sierologic studies showed significant antibody titres revealing a previous EBV infection; they were also negative for Toxotest, HbsAg, HIV and serogroup 3 and 9 Yersinia Enterocolitica. Histological findings showed necrotic changes and large foci of infiltration in the cortex and/or paracortex. They consisted of variable numbers of small lymphocytes, immunoblasts, macrophages and so-called plasmacytoid monocytes, neutrophils were absent. Immunohistochemistry revealed within the lesion T-Lymphocytes displaying a phenotype CD4+ while T-Lymphocytes CD8+ were observed in the paracortex and in the peripheral region of the lesion.
Department of Experimental Medicine and Pathology, University La Sapienza of Rome.
G
G
Soda
D
D
Bosco
A
A
Baiocchini
M
M
Melis
D000328:Adult; D005260:Female; D015614:Histiocytosis / Q000473:pathology*; D006801:Humans; D008199:Lymphadenitis / Q000473:pathology*; D009336:Necrosis