Salicylate alters 2-DG uptake in the auditory system: a model for tinnitus?
Because salicylate is known to produce tinnitus in humans and animals, the effect of salicylate on the auditory system of gerbils was investigated using [14C]2-deoxyglucose (2-DG). Salicylate treatment reduced activity in the inferior colliculus (IC), particularly in the high frequency part, whereas activation along some isofrequency contours was observed in auditory cortex. In contrast, in saline-treated controls the IC but not the auditory cortex was active. These results suggest that the sensation of subjective tinnitus may be generated within auditory brain structures. The 2-DG method may be used to measure tinnitus objectively in animals and also to evaluate tinnitus treatments.
Institute of Zoology, Technical University Darmstadt, Germany.
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E
Wallhäusser-Franke
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Braun
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Langner
D000818:Animals; D001303:Auditory Cortex / Q000187:drug effects*; D003847:Deoxyglucose / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D005849:Gerbillinae; D008297:Male; D012459:Salicylates / Q000494:pharmacology*; D014012:Tinnitus / Q000503:physiopathology*
D012459:Salicylates; D003847:Deoxyglucose