Hodgkin's disease and an extranodal marginal zone B-cell lymphoma in the small intestine: an unusual composite lymphoma.
We describe a 74-year-old man who presented with multifocal small bowel lesions, a large mesenteric mass, and enlarged mesenteric lymph nodes. In each of the extranodal sites and in two of three regional lymph nodes, there were classic histologic features of marginal zone B-cell lymphoma with adjacent areas of Hodgkin's disease, mixed cellularity subtype. Immunophenotypic analysis in the areas of low-grade B-cell lymphoma of mucosa-associated lymphoid tissue showed immunoreactivity for CD45RB and CD20 in the malignant small cell population. Conversely, the areas of Hodgkin's disease demonstrated positive immunoreactivity for CD15 and CD30 in the Reed-Sternberg cells and variants. Latent membrane protein for Epstein-Barr virus was also positive in the Reed-Sternberg cells and variants.
Department of Hematologic and Lymphatic Pathology, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000, USA.
N S
NS
Aguilera
L N
LN
Howard
M D
MD
Brissette
S L
SL
Abbondanzo
D000368:Aged; D018951:Antigens, CD20 / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D004854:Herpesvirus 4, Human / Q000276:immunology; D006689:Hodgkin Disease / Q000150:complications* / Q000473:pathology; D006801:Humans; D007078:Ileal Neoplasms / Q000737:chemistry / Q000150:complications* / Q000473:pathology; D007124:Immunoenzyme Techniques; D016130:Immunophenotyping; D017730:Ki-1 Antigen / Q000032:analysis; D017493:Leukocyte Common Antigens / Q000032:analysis; D016256:Lewis X Antigen / Q000032:analysis; D008198:Lymph Nodes / Q000737:chemistry / Q000473:pathology; D008207:Lymphatic Metastasis; D018442:Lymphoma, B-Cell, Marginal Zone / Q000737:chemistry / Q000150:complications* / Q000473:pathology; D008297:Male; D014763:Viral Matrix Proteins / Q000032:analysis
D018951:Antigens, CD20; D000956:Antigens, Viral; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D017730:Ki-1 Antigen; D016256:Lewis X Antigen; D014763:Viral Matrix Proteins; D017493:Leukocyte Common Antigens