Candida albicans arthritis one year after successful treatment of fungemia in a healthy infant.
Fungal arthritis in pediatric patients is rare and is most often associated with hematogenous spread to the affected joint. It is generally seen concomitant with, or shortly after, fungemia. We report a case of an immunocompetent patient in whom candidal arthritis developed 1 year after initial fungemia. The initial candidiasis was considered to be adequately treated with amphotericin B. The Candida isolates from the neonatal fungemia and subsequent arthritis were the some as identified by electrophoretic karyotype, restriction fragment length polymorphism analysis, and antifungal susceptibility testing. Pediatric candidal fungemia, arthritis, and their treatments are discussed.
Swanson
H
H
Department of Pediatric Infectious Disease, Albany Medical Center, New York 12203, USA.
Hughes
P A
PA
Messer
S A
SA
Lepow
M L
ML
Pfaller
M A
MA
D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000382:microbiology*; D002176:Candida albicans / Q000302:isolation & purification; D005260:Female; D016469:Fungemia / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D008826:Microbial Sensitivity Tests; D012150:Polymorphism, Restriction Fragment Length
D000935:Antifungal Agents; D000666:Amphotericin B