Cytogenetics of pediatric central nervous system tumors.
A cytogenetic analysis was performed on short-term cultures of 43 previously untreated childhood central nervous system neoplasms of various histology. The cells were obtained from pediatric patients, none of whom had received therapy before karyotypic evaluation. Successful chromosome studies were performed on 24 tumors. The most commonly detected structural abnormalities involved chromosomes 1 and 17. Other structural chromosome abnormalities involved chromosomes 3, 6, 8, 9, 11, 12, and 20.
Dipartimento di Pediatria, Università di Padova, Italy.
L
L
Sainati
S
S
Bolcato
A
A
Montaldi
P
P
Celli
M
M
Stella
A
A
Leszl
L
L
Silvestro
G
G
Perilongo
L
L
Cordero di Montezemolo
G
G
Basso
D000293:Adolescent; D001254:Astrocytoma / Q000235:genetics*; D001932:Brain Neoplasms / Q000235:genetics*; D018236:Carcinoma, Embryonal / Q000235:genetics*; D002528:Cerebellar Neoplasms / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D004806:Ependymoma / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D008297:Male; D008527:Medulloblastoma / Q000235:genetics*; D011003:Ploidies