Effects of atropine and loperamide on the agitating force and GI transit time in dogs in drug absorption studies.
There are difficulties in drug absorption studies using dogs because of different gastrointestinal (GI) conditions between these animals and humans, including shorter intestinal transit time and strong agitation force in the GI tract. We attempted to modify the agitation force and GI transit time using atropine and loperamide. The agitation force was examined based on in vitro/in vivo correlation for two controlled release (CR) formulations of acetaminophen. Atropine treatment considerably reduced the agitating force whereas that of loperamide did not.
National Institute of Health Sciences, Tokyo, Japan.
N
N
Katori
N
N
Aoyagi
S
S
Kojima
D000082:Acetaminophen / Q000008:administration & dosage / Q000493:pharmacokinetics; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D004285:Dogs; D016503:Drug Delivery Systems; D005772:Gastrointestinal Transit / Q000187:drug effects*; D007408:Intestinal Absorption; D008139:Loperamide / Q000494:pharmacology*; D008297:Male
D000082:Acetaminophen; D008139:Loperamide; D001285:Atropine