Inducer-specific regulators of tumor necrosis factor alpha production.
Novel potent regulators of tumor necrosis factor alpha (TNF-alpha) production by a human promyelocytic leukemia cell line, HL-60, were prepared. All the compounds showed inducer-specific and bidirectional regulation of TNF-alpha production, i.e., they enhanced 12-O-tetradecanoylphorbol-13-acetate-induced TNF-alpha production, while they inhibited okadaic acid-induced one.
Miyachi
H
H
Institute of Molecular & Cellular Biosciences, University of Tokyo, Japan.
Azuma
A
A
Hioki
E
E
Kobayashi
Y
Y
Iwasaki
S
S
Hashimoto
Y
Y
D002273:Carcinogens / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004357:Drug Synergism; D018922:HL-60 Cells; D006801:Humans; D019319:Okadaic Acid / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010797:Phthalimides / Q000138:chemical synthesis* / Q000494:pharmacology; D013268:Stimulation, Chemical; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D002273:Carcinogens; D010797:Phthalimides; D014409:Tumor Necrosis Factor-alpha; D019319:Okadaic Acid; D013755:Tetradecanoylphorbol Acetate