Sequence analysis of pre-S/S gene of hepatitis B virus strains of genotypes A, D, and F isolated in Brazil.
The nucleotide sequences of pre-S/S gene of nine hepatitis B virus strains (3 adw2, 3 ayw2, and 3 ayw 3) and of pre-S region of two adw4 isolates from Rio de Janeiro, Brazil, were determined. Phylogenetic analysis allowed to classify these strains into three genotypes, A, D and F, reflecting the diverse origin of the population. However, strains belonging to a same genotype were separated by a short evolutionary distance. The presence of aminoacid mutations into Pre-S region not found in hepatitis B viruses isolated in other parts of the world is described.
Department of Virology, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
M T
MT
Moraes
S A
SA
Gomes
C
C
Niel
D000595:Amino Acid Sequence; D001483:Base Sequence; D001938:Brazil; D019143:Evolution, Molecular; D015686:Gene Products, env / Q000737:chemistry* / Q000235:genetics; D015752:Genes, env; D005838:Genotype; D006515:Hepatitis B virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D017386:Sequence Homology, Amino Acid
D015686:Gene Products, env