Mothers' reactions to prenatal diagnostic procedures and dexamethasone treatment of congenital adrenal hyperplasia.
A retrospective survey of mothers' attitudes toward and experiences of chorionic villus sampling, amniocentesis and dexamethasone (DEX) treatment was conducted in 38 women who underwent a prenatal diagnostic procedure for congenital adrenal hyperplasia because of a previously affected child (n = 37) or because the mother herself was affected (n = 1). Both diagnostic procedures were well tolerated and almost every woman said that the anxiety or discomfort associated with the procedure was far outweighed by the value of knowing whether or not her fetus was affected. The earlier diagnostic information provided by chorionic villus sampling was highly valued. Maternal side-effects of DEX were common (75%) and more than one-third of the women rated one or more side-effects as "severe' (weight gain, fatigue, stomach pain, irritability, facial hair growth). Many women expressed anxiety about possible short- and long-term side-effects of DEX on their unborn children and themselves but all said they would undergo DEX treatment again to prevent virilization.
Department of Psychiatry, Cornell Medical College, New York, NY, USA.
P D
PD
Trautman
H F
HF
Meyer-Bahlburg
J
J
Postelnek
M I
MI
New
D000312:Adrenal Hyperplasia, Congenital / Q000175:diagnosis* / Q000188:drug therapy*; D000328:Adult; D000649:Amniocentesis / Q000523:psychology; D001007:Anxiety / Q000523:psychology; D001294:Attitude to Health; D015193:Chorionic Villi Sampling / Q000523:psychology; D003907:Dexamethasone / Q000627:therapeutic use*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D009035:Mothers / Q000523:psychology*; D011296:Prenatal Diagnosis / Q000523:psychology*; D012189:Retrospective Studies; D011795:Surveys and Questionnaires
D005938:Glucocorticoids; D003907:Dexamethasone