Modelling of indometacin and diclofenac sodium binding to the molecule of human serum albumin.
Modelling of the binding of two non-steroidal anti-inflammatory drugs, indometacin (CAS 53-86-1) and diclofenac sodium (CAS 15307-79-6) to the molecule of human serum albumin is presented. The models are based on the data obtained using difference spectroscopic technique. Speculations were made concerning the structural properties of the drugs and albumin molecules as well as the type of chemical interactions taking part in the drug-albumin binding. The proposed approach represents a more detailed investigation on the mechanism of drug-protein interactions.
Department of Chemistry, Faculty of Pharmacy, Sofia, Bulgaria.
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Russeva
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Mihailova
D000595:Amino Acid Sequence; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism*; D004008:Diclofenac / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000378:metabolism*; D008956:Models, Chemical; D008969:Molecular Sequence Data; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism*; D013055:Spectrophotometry, Infrared; D014508:Urea / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D012709:Serum Albumin; D004008:Diclofenac; D014508:Urea; D007213:Indomethacin