Polymorphic ventricular tachycardia induced by intracoronary injection of ioxaglate in a patient with borderline QT prolongation.
A 68-year-old female patient with borderline QT prolongation developed polymorphic ventricular tachycardia soon after intracoronary injection of ioxaglate. There was no coronary stenosis or vasospasm. To investigate abnormality of the ventricular repolarization, we recorded the monophasic action potential (MAP) during coronary angiography. Ioxaglate prolonged the MAP duration regionally in the perfused area and produced temporal dispersion of ventricular repolarization.
Emori
T
T
Department of Cardiovascular Medicine, Okayama University Medical School, Japan.
Fujieda
H
H
Ohe
T
T
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000368:Aged; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects*; D017023:Coronary Angiography / Q000009:adverse effects*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial; D007485:Ioxaglic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D008133:Long QT Syndrome / Q000000981:diagnostic imaging* / Q000503:physiopathology; D017180:Tachycardia, Ventricular / Q000139:chemically induced* / Q000503:physiopathology
D003287:Contrast Media; D007485:Ioxaglic Acid