Cancer-associated retinopathy in a patient with endometrial cancer.
OBJECTIVE
We studied a case of unusual retinopathy in a 60-year-old woman.


METHODS
The patient developed bilateral retinopathy with iridocyclitis and vitreitis. Corticosteroid therapy could not prevent deterioration of visual acuity and field. The electroretinogram became nonrecordable, and fluorescein angiogram exhibited retinal pigment epithelium window defects, fluorescein stainings to the vascular walls, and narrowed arterioles.


RESULTS
The patient underwent hysterectomy and lymphadenectomy for endometrial cancer in the corporis uteri. She was found to possess antibodies against retinal 34-kd protein, leading to a diagnosis of cancer-associated retinopathy.


CONCLUSIONS
Cancer-associated retinopathy may occur in patients with endometrial cancer of the corporis uteri.
Department of Ophthalmology, Jichi Medical School, Tochigi, Japan.
T
T
Ohkawa
H
H
Kawashima
S
S
Makino
Y
Y
Shimizu
H
H
Shimizu
I
I
Sekiguchi
S
S
Tsuchida
D000912:Antibodies, Neoplasm / Q000032:analysis; D000951:Antigens, Neoplasm / Q000276:immunology; D014408:Biomarkers, Tumor / Q000276:immunology; D002135:Calcium-Binding Proteins / Q000276:immunology; D004596:Electroretinography; D016889:Endometrial Neoplasms / Q000150:complications* / Q000628:therapy; D005128:Eye Diseases / Q000209:etiology; D005136:Eye Proteins; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D051597:Hippocalcin; D006801:Humans; D007044:Hysterectomy; D015863:Iridocyclitis / Q000209:etiology; D008074:Lipoproteins; D008197:Lymph Node Excision; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009419:Nerve Tissue Proteins; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D051603:Recoverin; D012164:Retinal Diseases / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D014792:Visual Acuity; D014822:Vitreous Body / Q000473:pathology
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D005136:Eye Proteins; D008074:Lipoproteins; D009419:Nerve Tissue Proteins; C496731:RCVRN protein, human; D051603:Recoverin; D051597:Hippocalcin