Acute leukemia during pregnancy: obstetric management and perinatal outcome of two cases.
The coexistence of leukemia and pregnancy is extremely rare. This paper describes two cases of acute promyelocytic leukemia diagnosed during the second trimester of pregnancy and the most suitable approach to the management of this situation is analyzed. Possible teratogenic effects of mono- or polychemotherapy during pregnancy, depending upon the gestational age at which chemotherapy is given, are discussed.
Department of Obstetrics and Gynaecology, La Paz Hospital, Autonoma University of Madrid, Spain.
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A
Requena
J G
JG
Velasco
J
J
Pinilla
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A
Gonzalez-Gonzalez
D000014:Abnormalities, Drug-Induced; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects; D003630:Daunorubicin / Q000008:administration & dosage / Q000009:adverse effects; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000628:therapy*; D008942:Mitoxantrone / Q000008:administration & dosage / Q000009:adverse effects; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000628:therapy*; D011256:Pregnancy Outcome; D012008:Recurrence; D013866:Thioguanine / Q000008:administration & dosage / Q000009:adverse effects
D003561:Cytarabine; D005047:Etoposide; D008942:Mitoxantrone; D013866:Thioguanine; D003630:Daunorubicin