MRI in subacute sclerosing panencephalitis.
Subacute sclerosing panencephalitis (SSPE) is a progressive, slow virus infection of the brain, caused by the measles virus, attacking children and young adults. We investigated 15 patients with SSPE by MRI, with 5 normal and 10 pathological results. In the early period, lesions were in the grey matter and subcortical white matter. They were asymmetrical and had a predilection for the posterior parts of the hemispheres. Later, high-signal changes in deep white matter and severe cerebral atrophy were observed. Parenchymal lesions significantly correlated with the duration of disease. A significant relationship between MRI findings and clinical stage was observed in the 1st year of the disease.
Tuncay
R
R
Department of Neurology, Istanbul Medical Faculty, University of Istanbul, Turkey.
Akman-Demir
G
G
Gökyigit
A
A
Eraksoy
M
M
Barlas
M
M
Tolun
R
R
Gürsoy
G
G
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D002552:Cerebral Ventricles / Q000473:pathology; D002648:Child; D003937:Diagnosis, Differential; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013344:Subacute Sclerosing Panencephalitis / Q000175:diagnosis*