[PT-INR as a parameter for anticoagulant therapy after valve replacement surgery].
We retrospectively analyzed the intensity of anticoagulant therapy in the 195 patients who underwent valve replacement surgery with mechanical valves. An optimal level or target range of prothrombin time-international normalized ratio (PT-INR) was sought. Previously, we employed a range of 10 to 25% of thrombotest value, which corresponded to the range of 1.5 to 3.5 of PT-INR value. In one patient who underwent mitral valve replacement, PT-INR valve was 1.72 when he developed an episode of cerebral thromboembolism. There was no tendency in PT-INR value in 51 patients who developed non-critical bleeding. As a while, PT-INR value was over 4.0 in 2 patients who required a in-hospital treatment for major bleeding complications. Based on our experience, we recommend a range of 2.0 to 3.0 of PT-INR value after valve replacement surgery with mechanical valves.
Department of Cardiothoracic Surgery, Asahikawa City Hospital, Japan.
Y
Y
Ishibashi
H
H
Aoki
J
J
Ohba
Y
Y
Kamikubo
K
K
Morimoto
A
A
Kumasaka
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use*; D001021:Aortic Valve / Q000601:surgery; D001760:Bleeding Time; D005260:Female; D006349:Heart Valve Diseases / Q000601:surgery; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery; D011184:Postoperative Period; D011517:Prothrombin Time; D012189:Retrospective Studies; D014261:Tricuspid Valve / Q000601:surgery
D000925:Anticoagulants