The relation between physician-diagnosed sinusitis, asthma, and skin test reactivity to allergens in 8-year-old children.
The purpose of this study was to assess the prevalence of sinusitis in a nonselected sample of children, and the relation of sinusitis to allergic rhinitis (AR), atopy, asthma, and cough in the same population sample. Of 1246 children enrolled at birth in the Tucson Children's Respiratory Study, 835 were studied at a mean age +/-SD of 8.6 +/- 0.7 years. Questionnaires asking about MD-Sinusitis, MD-AR, MD-Asthma, and cough were completed by parents. Skin tests for seven common aeroallergens in the Tucson area had been performed in 630 of the participating children at the mean age +/-SD of 6.3 +/- 0.9 years. Prevalence of MD-Sinusitis was 13.1%; 78% of subjects with MD-Sinusitis also had MD-AR. Detailed analysis of the relation between MD-Sinusitis and individual environmental allergens tested for showed that only a response to Bermuda grass pollen was significantly associated with MD-Sinusitis after controlling for MD-AR [adjusted odds ratio 2.3 (95% CI 1.2-4.3)]. Having MD-Sinusitis was also significantly associated with MD-Asthma and cough [odds ratios 3.0 (95% CI 1.8-5.2)] and 2.5 (95% CI 1.6-3.8), respectively]. However, logistic regression demonstrated that, after controlling for MD-AR and skin test reactivity, MD-Sinusitis was no longer significantly associated with MD-Asthma or cough. We conclude that MD-Sinusitis is a common condition in childhood. The main independent risk factors in our community for MD-Sinusitis were grass pollen and current MD-AR. MD-Sinusitis was not associated with MD-Asthma or with cough after controlling for skin test reactivity and for MD-AR.
Respiratory Sciences Center, University of Arizona, Tucson, USA.
E
E
Lombardi
R T
RT
Stein
A L
AL
Wright
W J
WJ
Morgan
F D
FD
Martinez
D000485:Allergens / Q000276:immunology; D001130:Arizona / Q000453:epidemiology; D001249:Asthma / Q000150:complications* / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003371:Cough / Q000150:complications; D006801:Humans; D007223:Infant; D011058:Pollen / Q000276:immunology; D015995:Prevalence; D012130:Respiratory Hypersensitivity / Q000150:complications*; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications* / Q000453:epidemiology; D012852:Sinusitis / Q000150:complications* / Q000453:epidemiology; D012882:Skin Tests; D011795:Surveys and Questionnaires
D000485:Allergens