Expression pattern of nuclear p53 is unique in COS-1 cells.
As p53 is transcriptionally inactive in COS-1 cells, we felt it would be interesting to study the relative time course of expression of nuclear p53 and the onset of S phase. Our results indicated that the expression of nuclear p53 lagged behind the onset of S phase in COS-1 cells. In addition, rapid nuclear expression of p53, probably resulting from nuclear translocation, occurred immediately after the addition of serum into COS1 cells. No such phenomena were found in B104-1 and BHK cells.
Lee
J C
JC
Department of Surgery, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C.
Lee
T S
TS
Ho
H Y
HY
Hsueh
H C
HC
Huang
W T
WT
Ho
Y R
YR
Lai
M D
MD
D000818:Animals; D019556:COS Cells / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism*; D004247:DNA / Q000096:biosynthesis*; D016196:S Phase; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D016159:Tumor Suppressor Protein p53; D004247:DNA