Pathogenesis of L-tryptophan eosinophilia myalgia syndrome.
Taken together, these studies suggest that many different etiologic agents alone or together may initiate the common final pathways of tissue pathologic response resulting in the clinical syndrome of eosinophilia, myalgias and fasciitis. Tryptophan itself may contribute to some of the scarring features of the illness, while impure L-tryptophan, and one or more of the impurities cause the characteristic features of the illness. The altered tryptophan metabolism in EMS is secondary to inflammation.
Sternberg
E M
EM
National Institute of Mental Health, Bethesda, Maryland 20892, USA.
D006916:5-Hydroxytryptophan / Q000633:toxicity; D000818:Animals; D004802:Eosinophilia / Q000139:chemically induced; D016603:Eosinophilia-Myalgia Syndrome / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology*; D004804:Eosinophils / Q000187:drug effects / Q000502:physiology; D006801:Humans; D014364:Tryptophan / Q000009:adverse effects* / Q000378:metabolism*
D014364:Tryptophan; D006916:5-Hydroxytryptophan