Vitamin K status influences brain sulfatide metabolism in young mice and rats.
The established role of vitamin K in nutrition is as a cofactor in the post-translational conversion of specific glutamyl to gamma-carboxyglutamyl (Gla) residues in a limited number of proteins. Administration of the vitamin K antagonist warfarin has previously been shown to decrease brain sulfatide concentrations and decrease brain galactocerebroside sulfotransferase (GST) activity in young mice. A dietary deficiency of vitamin K has now been shown to decrease (P < 0.01) brain sulfatide concentrations of 30-d-old mice significantly (by 21%). Male 21-d-old rats fed an excess of vitamin K for 7 or 14 d had 26 and 31% (P < 0.05) greater GST activity and 15 and 18% (P < 0.05) greater brain sulfatide concentrations, respectively, than controls fed a vitamin K-deficient diet. Male 21-d-old rats fed a diet containing 500 mg of phylloquinone/kg diet had an intermediate response and were vitamin K sufficient by normal criteria. The vitamin K response was observed when either phylloquinone or menaquinone-4 was fed as a source of the vitamin. These data suggest that in addition to its recognized role in Gla synthesis, vitamin K status is important in the maintenance of normal complex lipid sulfatide metabolism in young rats and mice.
Department of Microbiology and Immunology, CUNY Medical School, City College, New York, NY 10031, USA.
K S
KS
Sundaram
J H
JH
Fan
J A
JA
Engelke
A L
AL
Foley
J W
JW
Suttie
M
M
Lev
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D001923:Brain Chemistry; D005527:Food, Fortified; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D051381:Rats; D017207:Rats, Sprague-Dawley; D013433:Sulfoglycosphingolipids / Q000032:analysis / Q000378:metabolism*; D015238:Sulfotransferases / Q000032:analysis / Q000378:metabolism; D014812:Vitamin K / Q000097:blood* / Q000494:pharmacology / Q000502:physiology*; D010837:Vitamin K 1 / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology; D014859:Warfarin / Q000494:pharmacology
D013433:Sulfoglycosphingolipids; D014812:Vitamin K; D014859:Warfarin; D010837:Vitamin K 1; D015238:Sulfotransferases; C020556:galactosylceramide sulfotransferase