Ferristene as intestinal MR contrast agent. Distribution and safety of a fast ingestion procedure with oral metoclopramide.
OBJECTIVE
To compare the small bowel distribution and safety of a fast ingestion procedure of ferristene to those of the standard ingestion procedure.


METHODS
Sixty-four patients received 0.5 g/l ferristene in 800 ml water. Thirty-four patients of the fast ingestion group ingested ferristene with 20 mg of oral metoclopramide during the course of 30 min before MR imaging and received an i.v. injection of an antiperistaltic agent during the MR study. Thirty patients of the standard group ingested ferristene during the course of 2 h, without additional drugs. Ferristene distribution was assessed by 2 reviewers and adverse events were recorded.


RESULTS
More than 50% of the small bowel segments analyzed were filled with ferristene in 30 patients in the fast ingestion group and in 28 patients in the standard ingestion group. One patient in each group experienced nausea and/or vomiting. Some bloating or sensation of fullness was reported by 2 patients in the fast ingestion group and by 3 patients in the standard ingestion group.


CONCLUSIONS
The distribution of ferristene in the small bowel and the safety of the procedure were thus similar in the 2 groups using either a fast ingestion procedure with oral metoclopramide or the more time-consuming standard ingestion procedure.
Van Beers
B E
BE
Department of Radiology, St. Luc University Hospital, UCL, Brussels, Belgium.
Grandin
C
C
De Greef
D
D
Lundby
B
B
Pringot
J
J
D000284:Administration, Oral; D003287:Contrast Media / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005290:Ferric Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D007421:Intestine, Small / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008787:Metoclopramide / Q000008:administration & dosage*; D008875:Middle Aged; D012449:Safety; D013997:Time Factors
D003287:Contrast Media; D005290:Ferric Compounds; C101499:ferristene; D008787:Metoclopramide