Expression of m1 and m4 muscarinic receptor mRNA in the striatum following a selective lesion of striatonigral neurons.
Cholinergic stimulation has opposing effects on striatopallidal and striatonigral neurons. Most striatal projection neurons express m1 muscarinic receptor mRNA with m4 mRNA found in 40-50%. Expression of m4 mRNA is found in most preprotachykinin neurons but only a subset of preproenkephalin neurons, suggesting preferential localization of m4 receptors to striatonigral neurons. A volkensin lesion of striatonigral neurons reduced striatal m4 mRNA by 63% and m1 mRNA by only 18%, suggesting that preferential expression of m4 receptors by striatonigral neurons may contribute to their differential response.
Department of Neurology, University of Virginia Health Sciences Center, Charlottesville 22908, USA. mbh3y@virgina.edu
M B
MB
Harrison
M
M
Tissot
R G
RG
Wiley
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D006023:Glycoproteins; D017403:In Situ Hybridization; D008297:Male; D009699:N-Glycosyl Hydrolases; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D037121:Plant Lectins; D010940:Plant Proteins / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011976:Receptors, Muscarinic / Q000235:genetics*; D054790:Ribosome Inactivating Proteins, Type 2; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology
D006023:Glycoproteins; D037121:Plant Lectins; D010940:Plant Proteins; D012333:RNA, Messenger; D011976:Receptors, Muscarinic; D054790:Ribosome Inactivating Proteins, Type 2; C049134:volkensin; D009699:N-Glycosyl Hydrolases