Role of neuropeptide Y and its receptor subtypes in neurogenic pulmonary edema.
The effect of neuropeptide Y on the number of perivascular carbon deposits, assessed as a measure of lung vascular permeability, was examined in isolated perfused lung preparations of rats. The number of carbon particle deposits after bronchial application of neuropeptide Y was increased in a dose-dependent manner. In the presence of a beta-adrenoceptor antagonist, norepinephrine augmented the effects of neuropeptide Y. Peptide YY, an analog of neuropeptide Y, demonstrated a much lower potency for increasing the number of carbon deposits, and neuropeptide Y-(18-36), which elicits a weak antagonist action on the neuropeptide Y Y3 receptor, significantly decreased the neuropeptide Y-induced increase. Furthermore, examination of the influence of neuropeptide Y-(18-36) pretreatment on fibrin-induced neurogenic pulmonary edema, in rats, revealed a reduction of the protein concentration ratio of tracheal fluid to serum. Therefore, we conclude that neuropeptide Y may elevate vascular permeability in the pulmonary circulation, conceivably through the neuropeptide Y Y3 receptor, and that neuropeptide Y may in fact play a physiological role even in the in-situ pulmonary circulation.
Department of Anesthesiology, Nagoya University School of Medicine, Showa-ku, Japan.
A
A
Hirabayashi
K
K
Nishiwaki
Y
Y
Shimada
N
N
Ishikawa
D000818:Animals; D002199:Capillary Permeability; D002244:Carbon / Q000378:metabolism; D008297:Male; D009478:Neuropeptide Y / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011654:Pulmonary Edema / Q000209:etiology*; D011738:Pyrilamine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017476:Receptors, Neuropeptide Y / Q000145:classification / Q000502:physiology*
D009478:Neuropeptide Y; D017476:Receptors, Neuropeptide Y; D002244:Carbon; D011433:Propranolol; D011738:Pyrilamine; D009638:Norepinephrine