Structure and organization of the gene encoding human selenoprotein.
We have isolated a genomic clone encoding human selenoprotein P including the putative promoter region. The gene spans 12 kb and consists of five exons with a start codon in the second exon. A typical TATA sequence, the recognition motifs for a GATA-binding factor and the liver-specific factors, HNF-1 and HNF-3, were detected upstream from the transcription start point.
Laboratory of Biochemistry, Aichi Cancer Center Research Institute, Nagoya, Japan.
Y
Y
Yasui
K
K
Hasada
J G
JG
Yang
O
O
Koiwai
D001483:Base Sequence; D003062:Codon / Q000235:genetics; D005091:Exons / Q000235:genetics; D005796:Genes / Q000235:genetics*; D006801:Humans; D007438:Introns / Q000235:genetics; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic / Q000235:genetics; D011506:Proteins / Q000235:genetics*; D051149:Selenoprotein P; D051140:Selenoproteins
D003062:Codon; D011506:Proteins; D051149:Selenoprotein P; D051140:Selenoproteins