Increased bone marrow uptake of Ga-67 in patients with fever of unknown origin.
The relationships of clinical diagnosis, the effect of blood chemistry, and the clinical implication of increased Ga-67 citrate uptake in the bone marrow of patients with signs and symptoms of fever of unknown origin were studied. Based on intensity of Ga-67 citrate uptake in bone marrow, patients were classified as follows: type 1 when there was no evidence or very faint bone marrow uptake in the vertebrae, type 2 when mild to moderate, type 3 when uptake was severe. The relationships of WBC count, hemoglobin, hematocrit, serum iron, and unsaturated iron-binding capacity with the occurrence of increased bone marrow uptake in the different groups were noted. Analysis of variance with Fisher's protected least significant difference was used. A P value of less than 0.05 was considered significant. The results showed significant differences between types 1 and 2 and between types 1 and 3 for WBC counts, hemoglobin, and hematocrit levels. Serum iron concentration and unsaturated iron-binding capacity, however, did not show any significant differences. Significant changes in WBC count, hemoglobin and hematocrit in patients with fever of unknown origin were accompanied by a varying intensity of Ga-67 citrate uptake in the bone marrow.
Department of Radiology, Miyazaki Medical College, Japan.
L G
LG
Flores
S
S
Jinnouchi
S
S
Nagamachi
T
T
Ohnishi
S
S
Futami
K
K
Watanabe
D000328:Adult; D000704:Analysis of Variance; D001853:Bone Marrow / Q000000981:diagnostic imaging*; D005260:Female; D005335:Fever of Unknown Origin / Q000097:blood / Q000000981:diagnostic imaging*; D005710:Gallium Radioisotopes; D006400:Hematocrit; D006452:Hemoglobinometry; D006801:Humans; D007501:Iron / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging
D005710:Gallium Radioisotopes; D007501:Iron