Papillon-Lefèvre syndrome. Analysis of peripheral blood lymphocyte subsets.
We have studied the peripheral blood lymphocyte populations in our 6 patients (2 female and 4 male) with a mean age of 11.19 with Papillon-Lèfevre Syndrome (PLS) using adequate monoclonal antibodies and double coloured flow cytometry. Total B, T, CD4, CD8, CD29, CD45RA, NK, HLA-DR cells were studied. Total B, T, CD4 and CD8 lymphocytes were within normal limits. We have observed an increase in the CD29 lymphocytes and NK cells and a decrease in CD45RA lymphocytes. We think that these findings are important in explaining B lymphocyte activation and in the pathogenesis of the PLS.
Department of Periodontology, School of Dentistry, Istanbul School of Medicine, University of Istanbul, Turkey.
E
E
Firatli
N
N
Gürel
A
A
Efeoğlu
D016301:Alveolar Bone Loss / Q000473:pathology; D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes / Q000473:pathology; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000473:pathology; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005434:Flow Cytometry; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D019012:Integrin beta1 / Q000032:analysis; D007694:Killer Cells, Natural / Q000473:pathology; D017493:Leukocyte Common Antigens / Q000032:analysis; D008213:Lymphocyte Activation; D016131:Lymphocyte Subsets / Q000145:classification* / Q000473:pathology; D008297:Male; D010214:Papillon-Lefevre Disease / Q000097:blood* / Q000473:pathology; D017622:Periodontal Attachment Loss / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology; D014085:Tooth Migration / Q000473:pathology; D014086:Tooth Mobility / Q000473:pathology
D000911:Antibodies, Monoclonal; D006684:HLA-DR Antigens; D019012:Integrin beta1; D017493:Leukocyte Common Antigens