Kynurenic acid-enhancing and anti-ischemic effects of the potent kynurenine 3-hydroxylase inhibitor FCE 28833 in rodents.
Pharmacia, R&D CNS, Nerviano, Italy.
C
C
Speciale
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M
Cini
H Q
HQ
Wu
P
P
Salvati
R
R
Schwarcz
A
A
Molinari
M
M
Calabresi
M
M
Varasi
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D002087:Butyrates / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005849:Gerbillinae; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D006867:Hydrolases / Q000378:metabolism; D002546:Ischemic Attack, Transient / Q000473:pathology / Q000517:prevention & control*; D007736:Kynurenic Acid / Q000378:metabolism*; D050601:Kynurenine 3-Monooxygenase; D008099:Liver / Q000201:enzymology; D008297:Male; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D002087:Butyrates; D004791:Enzyme Inhibitors; C104254:FCE 28833; D018696:Neuroprotective Agents; D006899:Mixed Function Oxygenases; D050601:Kynurenine 3-Monooxygenase; D006867:Hydrolases; C021480:kynureninase; D007736:Kynurenic Acid