Uterine leiomyosarcoma with osteoclast-like giant cells: histopathological and cytological observations.
A 56 year old woman presented with abnormal uterine bleeding. Except for a myomatous uterus, no other abnormalities were noted on physical examination and in radiographic and serologic studies. The hysterectomy specimen revealed an 8 cm uterine fundic tumor composed of two histologically different patterns that merged with one another; one was a well differentiated leiomyosarcoma and the other a mixture of osteoclast-like giant cells (OGC) and plump spindle cells whose cell borders blended, resembling the histology of giant cell tumor of bone. Immunohistochemical studies showed positive staining for muscle actin, alpha-smooth muscle actin, and KP-1 (CD68) in both the spindle cells and OGC. The latter also stained for alpha-1-antitrypsin and alpha-1-antichymotrypsin. These findings suggested that OGC may be formed by the fusion of spindle cells of leiomyosarcoma and also express histiocytic markers.
Department of Pathology, Fukushima Medical College, Jusendoh General Hospital, Japan.
K
K
Watanabe
H
H
Hiraki
M
M
Ohishi
K
K
Mashiko
H
H
Saginoya
T
T
Suzuki
D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007890:Leiomyosarcoma / Q000473:pathology*; D008875:Middle Aged; D010010:Osteoclasts / Q000473:pathology; D014594:Uterine Neoplasms / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
D014746:Vimentin