Congenital bilateral anorchia: clinical, hormonal and imaging study in 12 cases.
Twelve anorchid pre-pubertal and post-pubertal patients, aged between 8.5 and 41 years, were studied. The FSH and LH basal levels as well as their responses to Gn-RH (100 micrograms i.v.) were increased and prolonged in the post-pubertal patients. The testosterone levels were in the pre-pubertal range and failed to increase after HCG administration (1500 I.U. t.i.d. for 3 days). Ultrasonography of the pelvis was performed in all the patients. Computed tomography and magnetic resonance of the abdomen were also performed in 6 and 5 patients respectively. These techniques failed to show any testicular tissue. Lastly, in 4 patients, surgical exploration confirmed the absence of testicular structure.
De Rosa
M
M
Department of Endocrinology and Molecular and Clinical Oncology, School of Medicine, University Federico II, Naples, Italy.
Lupoli
G
G
Mennitti
M
M
Zarrilli
S
S
Mirone
V
V
Lombardi
G
G
D000293:Adolescent; D000328:Adult; D002648:Child; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D012734:Disorders of Sex Development / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology*; D005640:Follicle Stimulating Hormone / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D011388:Prolactin / Q000097:blood; D011859:Radiography; D013737:Testis / Q000002:abnormalities*; D013739:Testosterone / Q000097:blood
D006063:Chorionic Gonadotropin; D012739:Gonadal Steroid Hormones; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone