The presence of CD28-negative T cells in a patient with multicentric Castleman's disease.
We found increased numbers of CD28-negative T cells in a patient with multicentric Castleman's disease (MCD), who also had significantly decreased interleukin-2 (IL-2) production and impaired T-cell proliferation. The presence of CD28-negative T cells may be indicative of a functional T-cell defect in MCD.
Department of Hematology, Showa University School of Medicine, Tokyo, Japan.
T
T
Ishiyama
M
M
Koike
T
T
Kakimoto
Y
Y
Akimoto
N
N
Tsuruoka
D018106:CD28 Antigens / Q000378:metabolism*; D005871:Castleman Disease / Q000276:immunology*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008213:Lymphocyte Activation; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D018106:CD28 Antigens