The effect of levenogesterol (Norplant) contraception on coagulation as measured by antithrombin-III levels.
OBJECTIVE
To determine the effect of contraception given immediately postpartum on coagulation as measured by antithrombin III.


METHODS
In this prospective study, parturients (n = 85) self selected three means of postpartum contraception: levenorgesterol implants, oral contraceptives, or a barrier method.


RESULTS
Baseline coagulation was assessed by antithrombin-III levels in each of the 85 women within 48 hours of delivery (100.35 +/- 1.61%) and at one (109.1 +/- 1.89%) and six (105.51 +/- 1.71%) weeks postpartum. There was a rise in antithrombin-III after delivery but there were no significant differences between the groups.


CONCLUSIONS
The levenorgesterol implant system did not cause a decrease in antithrombin-III in normal parturients.
Pryor
J A
JA
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson 39216-4505, USA.
Cooper
K R
KR
Bass
J D
JD
Hampton
H L
HL
Rock
W A
WA
Morrison
J C
JC
D000990:Antithrombin III / Q000032:analysis*; D001777:Blood Coagulation / Q000187:drug effects*; D003271:Contraceptive Agents, Female / Q000494:pharmacology*; D003274:Contraceptive Devices, Female; D003276:Contraceptives, Oral; D005260:Female; D006801:Humans; D016912:Levonorgestrel / Q000494:pharmacology*; D049590:Postpartum Period; D011247:Pregnancy; D011446:Prospective Studies
D003271:Contraceptive Agents, Female; D003276:Contraceptives, Oral; D016912:Levonorgestrel; D000990:Antithrombin III