Prenatal and postpartum pharmacokinetics of stavudine (2',3'-didehydro-3'-deoxythymidine) and didanosine (dideoxyinosine) in pigtailed macaques (Macaca nemestrina).
Stavudine (5 mg/kg of body weight; n = 7) or didanosine (3.2 mg/kg; n = 4) was administered as an intravenous bolus to pregnant pigtailed macaques (Macaca nemestrina) near term and 4 to 5 weeks postpartum. No significant differences were found between the prenatal and postpartum total plasma drug clearance, steady-state volume of distribution, terminal plasma drug half-life, mean body residence time, or recovery of unchanged drug in urine. These data indicate that pregnancy does not affect the pharmacokinetics of stavudine or didanosine in M. nemestrina.
Odinecs
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Department of Pharmaceutics, University of Washington, Seattle 98195, USA.
Pereira
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Nosbisch
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Unadkat
J D
JD
D000818:Animals; D000831:Animals, Newborn; D019380:Anti-HIV Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D016049:Didanosine / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D005260:Female; D006207:Half-Life; D007262:Infusions, Intravenous; D008254:Macaca nemestrina; D049590:Postpartum Period / Q000378:metabolism*; D011247:Pregnancy; D018119:Stavudine / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
D019380:Anti-HIV Agents; D018119:Stavudine; D016049:Didanosine