Endothelial changes in phakic eyes with anterior chamber intraocular lenses to correct high myopia.
OBJECTIVE
To evaluate the long-term endothelial cell loss after implantation of Worst-Fechner and Baikoff ZB5M anterior chamber intraocular lenses.


METHODS
Jiménez-Díaz Foundation and San Carlos University Hospital, Madrid, Spain.


METHODS
Preoperative and serial postoperative specular microscopy was performed on 30 eyes that had a Worst-Fechner lens and on 28 eyes that had a Baikoff ZB5M lens to correct high myopia. A video specular microscope adapted to an image analysis system was used to analyze the endothelium for cell density. Follow-up was 24 months.


RESULTS
In the Worst-Fechner lens group, postoperative endothelial cell density was significantly lower than preoperative density at all times (P < .001). Endothelial cell loss was 7.26% at 3 months, 10.64% at 6 months, 13.00% at 12 months, and 17.60% at 24 months. In the Baikoff ZB5M lens group, postoperative cell density was also significantly lower than preoperative density at all times (P < .001). It was 7.50% at 3 months, 10.94% at 6 months, 12.33% at 12 months, and 12.30% at 24 months. Cell loss did not stabilize between 1 and 2 years after surgery in the Worst-Fechner group (P = .047). However, no additional cell loss was noted during this period in the Baikoff ZB5M group (P = .968). Endothelial cell densities in the two groups did not differ during the first year. However, 2 years after surgery, cell density in the Worst-Fechner group was significantly lower than it was in the ZB5M group (P = .048).


CONCLUSIONS
Endothelial cell loss during the first year was similar in eyes with Worst-Fechner and Baikoff ZB5M lenses; however, at 2 years after surgery, endothelial cell loss was higher in eyes with Worst-Fechner lenses than it was in eyes with Baikoff ZB5M lenses.
Pérez-Santonja
J J
JJ
Department of Ophthalmology, Jiménez-Díaz Foundation, Autonomous University of Madrid School of Medicine, Spain.
Iradier
M T
MT
Sanz-Iglesias
L
L
Serrano
J M
JM
Zato
M A
MA
D000328:Adult; D000867:Anterior Chamber / Q000473:pathology / Q000601:surgery*; D002452:Cell Count; D004728:Endothelium, Corneal / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007910:Lenses, Intraocular / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000503:physiopathology / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D011446:Prospective Studies; D014792:Visual Acuity