The role of tryptophan in DON-induced feed rejection.
Deoxynivalenol (DON, vomitoxin) commonly produced by Fusarium fungi can alter feeding behaviour of pigs and other farm animals. The effects of dietary tryptophan (TRP, precursor of brain amine serotonin) in combination with DON were examined in mice to determine if TRP can modulate DON toxicity. Results indicated that brain TRP can be influenced by dietary TRP, but no evidence of TRP potentiating DON toxicity was observed. Higher TRP levels likely induced amino acid imbalance leading to weight gain suppression.
Rotter
B A
BA
Centre for Food and Animal Research, Agriculture and Agri-Food Canada, Ottawa, Ontario, Canada.
Prelusky
D B
DB
Thompson
B K
BK
D000284:Administration, Oral; D000818:Animals; D001923:Brain Chemistry; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D014255:Trichothecenes / Q000633:toxicity*; D014364:Tryptophan / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D015430:Weight Gain / Q000187:drug effects*
D014255:Trichothecenes; D014364:Tryptophan; C007262:deoxynivalenol