Effect of ovariectomy on magnetic resonance T2* in rat femur.
Measurements have been made in the rat femur in vivo and ex vivo by using an asymmetric spin echo technique of T2(1), the susceptibility contribution to T2*. The trabecular spacing in this study in rat bone is considerably less than in previous studies in the human. A significant increase in T2(1) was seen in vivo 3 mm proximal to the growth plate with ovariectomy (a model of osteopenia), from 8.1 +/- 0.7 to 10.0 +/- 0.6 ms. Parallel changes in trabecular bone mineral density measured by quantitative computed tomography were found. T2(1) was higher in living bones than in the same bones measured post mortem.
Department of Vascular Inflammatory and Musculoskeletal Research, Zeneca Pharmaceuticals, Macclesfield, Cheshire, United Kingdon.
D
D
Checkley
A J
AJ
Millest
D
D
Johnstone
J C
JC
Waterton
D015502:Absorptiometry, Photon; D000818:Animals; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000473:pathology; D005260:Female; D005269:Femur / Q000033:anatomy & histology*; D009682:Magnetic Resonance Spectroscopy; D010052:Ovariectomy; D051381:Rats