A fatal case of methotrimeprazine overdose.
Fatal ingestion of methotrimeprazine is unusual, and while therapeutic drug levels are established as concentrations between 0.02 to 0.14 mg/L, fatal levels are not. The following describes a case of fatal suicidal ingestion of methotrimeprazine in which the measured concentration of methotrimeprazine in the blood was 4.1 mg/L. In addition, the major metabolites of methotrimeprazine, desmethylmethotrimeprazine, and methotrimeprazine sulfoxide were also measured at 2.0 and 1.8 mg/L, respectively. Methotrimeprazine and its metabolites were also measured in urine, bile, and vitreous humor. These results are compared with other case reports of methotrimeprazine fatalities reported in the literature.
Avis
S P
SP
Department of Justice, Province of Newfoundland and Labrador, Health Sciences Center, St. John's, Canada.
Holzbecher
M D
MD
D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000506:poisoning*; D002849:Chromatography, Gas / Q000379:methods; D017809:Fatal Outcome; D005554:Forensic Medicine; D006801:Humans; D008297:Male; D008728:Methotrimeprazine / Q000493:pharmacokinetics / Q000506:poisoning*; D013405:Suicide
D018712:Analgesics, Non-Narcotic; D008728:Methotrimeprazine