Fetal malformations in an epileptic pregnant woman treated with carbamazepine.
We report a case of an epileptic pregnant woman at 20 weeks of gestation treated with carbamazepine, whose fetus was affected by major malformations probably due to the drug teratogenicity. After a therapeutic abortion minor malformations were also found. After seven months the patient was pregnant again, at 14 weeks of gestation she aborted spontaneously a fetus with no malformations. During this pregnancy the patient took a reduced dosage of carbamazepine.
Second Department of Obstetrics and Gynaecology, University of Bari, Italy.
O
O
Ceci
P
P
Loizzi
G
G
Caruso
F
F
Caradonna
R
R
Clemente
R
R
Ferreri
D000014:Abnormalities, Drug-Induced / Q000000981:diagnostic imaging / Q000209:etiology*; D000025:Abortion, Eugenic; D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D002220:Carbamazepine / Q000008:administration & dosage / Q000009:adverse effects*; D004827:Epilepsy / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011262:Pregnancy Trimester, Second; D016216:Ultrasonography, Prenatal
D000927:Anticonvulsants; D002220:Carbamazepine