Identification of a new series of fumonisins containing 3-hydroxypyridine.
A new series of fumonisins, designated FP1-3, were isolated from a culture of Fusarium moniliforme (M-2285) grown on solid corn. The new compounds contain a 3-hydroxypyridinium moiety at the C-2 position of the eicosane backbone instead of the amine found in the B series of fumonisins. The new fumonisins were characterized by UV, LC-MS-MS, 1H NMR, and 13C NMR. LC-MS analysis of culture extracts indicates that the new fumonisins can occur at levels up to approximately one-third the amount of their amine-containing analogues (FB1, FB2, and FB3).
Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA. smm@fdacf.ssw.dhhs.gov
S M
SM
Musser
M L
ML
Gay
E P
EP
Mazzola
R D
RD
Plattner
D002264:Carboxylic Acids / Q000737:chemistry* / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D037341:Fumonisins; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009183:Mycotoxins / Q000737:chemistry* / Q000302:isolation & purification; D011725:Pyridines / Q000737:chemistry* / Q000302:isolation & purification; D013056:Spectrophotometry, Ultraviolet
D002264:Carboxylic Acids; D037341:Fumonisins; D009183:Mycotoxins; D011725:Pyridines; C102484:fumonisin FP1; C102485:fumonisin FP2; C102486:fumonisin FP3; C023500:3-hydroxypyridine