Adult T-cell leukemia with multiple lymphomatous polyposis of the gastrointestinal tract.
A rare case of adult T-cell leukemia (ATL) in which multiple lymphomatous polyposis (MLP) was revealed throughout the entire gastrointestinal tract is reported here. The polypectomy specimens taken from the rectum revealed infiltration of neoplastic T-cells, the integration of HTLV-1 proviral DNA, and increased CD4 (OKT4) and CD25 (IL-2R) cells. The analysis of surface markers of the lymphocytes from polypoid lesions may be useful for elucidating cell tropism and homing properties in the gastrointestinal tract. Although MLP has always been associated with B-cell lymphoma in the Western world, it is important for clinicians and pathologists to be aware that MLP may be caused by the infiltration of ATL cells.
Itsuno
M
M
Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
Makiyama
K
K
Muta
K
K
Furukawa
K
K
Hara
K
K
Tabata
S
S
Soda
H
H
Ikeda
S
S
Takashima
H
H
Fukuda
Y
Y
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D003131:Combined Modality Therapy; D016099:Endoscopy, Gastrointestinal; D017809:Fatal Outcome; D005770:Gastrointestinal Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007417:Intestinal Polyps / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D008297:Male