Discordant Duane's retraction syndrome in monozygotic twins.
OBJECTIVE
To evaluate whether differences in the intrauterine environment caused discordant Duane's retraction syndrome in monozygotic twins.


METHODS
Pathology records were reviewed to determine monozygosity.


RESULTS
Discordant Duane's retraction syndrome was present in twin boys with identical genetic foundations who had different intrauterine environments. The placenta indicated areas of anastomosis between the two umbilical cords suggestive of twin-to-twin transfusion that resulted in a visible growth discordance.


CONCLUSIONS
Intrauterine environment influences ocular development, and twin-to-twin transfusion may cause Duane's retraction syndrome.
Kansas University Medical Center, USA. desmith5@msn.com
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Cibis
D004200:Diseases in Twins; D004370:Duane Retraction Syndrome / Q000235:genetics* / Q000473:pathology; D005260:Female; D005330:Fetofetal Transfusion / Q000150:complications; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000209:etiology; D008297:Male; D010920:Placenta / Q000473:pathology; D011247:Pregnancy; D014430:Twins, Monozygotic