The influence of ionophores on the duration of xylazine-ketamine anestheisa and the hepatic cytochrome P-450 content of broiler chickens.
This study examined the effects of feeding monensin, lasalocid or salinomycin (at 1x and 2x therapeutic levels for 20 d) on the duration of xylazine+ketamine sleep time and the hepatic cytochrome P-450 content in broiler chickens of different age groups (3- and 6-w-old). The 3-w-old birds fed 120 ppm salinomycin had a reduced xylazine+ketamine sleep time as compared to control (no drug). The 6-w birds had a sleep time similar to the controls. Associated with ionophore feeding was a trend toward P-450 induction when compared to controls. Increased P-450 content was statistically significant in the 3-w birds fed 90 ppm lasalocid and in the 6-w birds fed 200 ppm monensin. Ionophore administration above recommended levels gave conflicting results for duration of xylazine+ketamine sleep time and hepatic cytochrome P-450 levels. The isozymes of cytochrome P-450 responsible for xylazine and ketamine metabolism may be different from those induced by the ionophores. There was no significant age-related difference in ionophore effects on cytochrome P-450 content.
Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater 74078, USA.
J D
JD
Roder
S
S
Sangiah
J L
JL
Lish
C W
CW
Qualls
D000704:Analysis of Variance; D000778:Anesthetics, Dissociative / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D002645:Chickens; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D007476:Ionophores / Q000633:toxicity*; D007649:Ketamine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007832:Lasalocid / Q000633:toxicity; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008985:Monensin / Q000633:toxicity; D011714:Pyrans / Q000633:toxicity; D012890:Sleep / Q000187:drug effects; D014991:Xylazine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000095662:Polyether Polyketides
D000778:Anesthetics, Dissociative; D003577:Cytochrome P-450 Enzyme System; D007476:Ionophores; D007649:Ketamine; D007832:Lasalocid; D008985:Monensin; D011714:Pyrans; D014991:Xylazine; C010327:salinomycin; D000095662:Polyether Polyketides