Neuroleptic dosing in Hispanic and Asian Inpatients with schizophrenia.
This study is the second in a series examining the prescribing of antipsychotic medication to patients with schizophrenia in cross-cultural clinical programs. A computer search identified all patients with the diagnosis of "schizophrenia" treated during a 1-year period in an inpatient Hispanic and Asian psychiatric unit(s); second computer search identified a matched (admission date) sample of Anglo patients from the general inpatient psychiatry services. The medication variables included type of neuroleptic drug used, the maximum dose, the stabilized dose (i.e., neuroleptic dose at discharged and the dose associated with first report of extrapyramidal symptoms. Neuroleptic doses were converted to chlorpromazine (CPZ) equivalents and corrected for body weight to a standard of 68 kg. Oneway analysis of variance procedures were used to compare both actual and standardized neuroleptic CPZ across the three samples, these statistical comparisons were completed for both maximum and stabilized dose(s). The analysis with maximum dose revealed a significant main effect for both actual (p < 0.05) and standardized CPZ (p < 0.05). Similar results were also found for stabilized dose with both actual (p < 0.05) and standardized CPZ (p < 0.05). Examination of the direction of mean differences for both medication dosing variables using both CPZ comparisons revealed that the patients in general sample received significantly larger doses of antipsychotic medication than either Asian or Hispanic patients.
Mount Sinai School of Medicine, Elmhurst, NY, USA.
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Y
Collazo
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Tam
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J
Sramek
J
J
Herrera
D000328:Adult; D000704:Analysis of Variance; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D003431:Cross-Cultural Comparison; D005006:Ethnicity; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D010045:Outpatients; D012189:Retrospective Studies; D012559:Schizophrenia / Q000188:drug therapy* / Q000208:ethnology; D014481:United States
D014150:Antipsychotic Agents