Mucociliary function in patients with nasal polyps.
Patients with nasal polyposis complain of nasal blockage and rhinorrhoea, which may be due to impaired mucociliary clearance. The saccharine clearance time and ciliary beat frequency of samples of ciliated epithelium from patients with nasal polyps was measured. We also studied the effect of fluid from the oedematous stroma of nasal polyps and of histamine and prostaglandin (PG) D2, E2 and F2 alpha on the cilia from normal individuals. Polyp fluid was found to increase ciliary beat frequency. Histamine and PGD2 had no effect, but PGE2 and PGF2 alpha both increased ciliary beat frequency and so may cause the ciliostimulatory effect of polyp fluid. The saccharine clearance time was prolonged in three of nine patients, but ciliary beat frequency was only slightly reduced in one of these. Thus, where mucociliary clearance is reduced, it is likely to be due to abnormalities of mucus rather than impaired ciliary activity.
Slater
A
A
Department of Pathology, Medical School, University of Birmingham, UK.
Smallman
L A
LA
Logan
A C
AC
Drake-Lee
A B
AB
D002923:Cilia / Q000378:metabolism; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D004848:Epithelium / Q000378:metabolism; D006632:Histamine / Q000493:pharmacokinetics; D006801:Humans; D009079:Mucociliary Clearance; D015508:Nasal Obstruction / Q000209:etiology; D009298:Nasal Polyps / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D011453:Prostaglandins / Q000493:pharmacokinetics
D011453:Prostaglandins; D006632:Histamine