Fixation of Interceed does not improve its efficacy against adhesion formation in rats.
A randomized controlled trial was performed in 30 Sprague-Dawley white rats to compare the efficacy of the synthetic adhesion-barrier Interceed (Johnson & Johnson Medical Inc.) when fixed in place using 6/0 vicryl sutures or lying freely on damaged tissues. The rats were randomly assigned to 3 groups; control, Interceed (fixed) and Interceed (free). Adhesion formation was measured 2 weeks later, using a scoring system related to extent and density. There was no significant difference whether the adhesion-barrier was fixed in place with sutures or not, so that the fixation of Interceed to cover traumatized tissues does not appear to provide any benefits against adhesion formation in rats.
Department of Obstetrics and Gynaecology, Faculty of Medical Sciences.
S
S
Ramsewak
G
G
Narayansingh
K
K
Bassaw
W
W
Harewood
E
E
Bridgewater
D000291:Adnexal Diseases / Q000517:prevention & control*; D000818:Animals; D002483:Cellulose, Oxidized / Q000494:pharmacology*; D005260:Female; D011183:Postoperative Complications / Q000517:prevention & control; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D000267:Tissue Adhesions / Q000517:prevention & control
D002483:Cellulose, Oxidized; C060002:INTERCEED