Cerebral uric acid increases following experimental traumatic brain injury in rat.
Following traumatic brain injury (TBI), cortical and thalamic areas were analyzed histologically and by high-performance liquid chromatography with electrochemical detection for uric acid at various survival times. Following TBI, cortical uric acid was elevated by ten-fold at 24 and 48 h, but not at 1 h post-TBI. Histological evidence of neurodegeneration was found not only in cortex but also in the anteroventral thalamus. These data suggest that as in stroke, uric acid measurements may be a convenient and sensitive method for measuring peroxidative status in TBI.
Department of Neurosurgery, Medical College of Pennsylvania, Philadelphia 19102-1192, USA.
E C
EC
Tayag
S N
SN
Nair
S
S
Wahhab
C D
CD
Katsetos
J W
JW
Lighthall
J C
JC
Lehmann
D000818:Animals; D001930:Brain Injuries / Q000378:metabolism* / Q000473:pathology; D002540:Cerebral Cortex / Q000378:metabolism* / Q000473:pathology; D002851:Chromatography, High Pressure Liquid; D004563:Electrochemistry; D007839:Functional Laterality; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013788:Thalamus / Q000378:metabolism* / Q000473:pathology; D013997:Time Factors; D014527:Uric Acid / Q000378:metabolism*
D014527:Uric Acid