Human chorionic gonadotropin: pharmacokinetics of subcutaneous administration.
The objective of the present study was to evaluate the pharmacokinetics of human chorionic gonadotropin (hCG) following different regimens of subcutaneous and intramuscular single-dose administration. Two hypogonadotropic hypogonadal volunteers received hCG injections without prior ovarian stimulation. The regimens included a single dose of 10,000 IU hCG either subcutaneously or intramuscularly, or 5000 IU hCG intramuscularly. Serum beta-hCG concentrations were measured periodically up to 13 days after hCG administration. Each of the three regimens exhibit a similar pharmacokinetic profile and the highest serum beta-hCG concentrations were achieved with a dose of 10,000 IU administered subcutaneously. Seven days after hCG administration beta-hCG was detectable only after subcutaneous or intramuscular administration of 10,000 IU, but not after a single intramuscular injection of 5000 IU. From the preliminary results of the study it is suggested that a single intramuscular dose of 5000 IU hCG might be sufficient to trigger ovulation, but for luteal-phase support a higher dose may be needed. Subcutaneous administration of hCG for the induction of ovulation or luteal-phase support in gonadotropin-induced cycles is feasible and might offer a better tolerance and cost-effectiveness of infertility treatments, leading to their further simplification.
Weissman
A
A
Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Israel.
Lurie
S
S
Zalel
Y
Y
Goldchmit
R
R
Shoham
Z
Z
D000328:Adult; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007006:Hypogonadism / Q000378:metabolism; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D010349:Patient Compliance; D013997:Time Factors
D018997:Chorionic Gonadotropin, beta Subunit, Human