The cytoskeleton and neurotransmitter receptors.
The neuronal cytoskeleton consists of microtubules and microfilaments that can interact with membrane proteins including neurotransmitter receptors and ion channels. Ligand-gated ion channels, such as nicotinic acetylcholine receptors, glycine receptors, glutamate receptors and gamma-aminobutryic acidA (GABAA) receptors, are known to cluster in plasma membranes. Studies suggest that postsynaptic ligand-gated channels form clusters that are anchored in the plasma membrane by interacting with cytoskeletal components and these clusters may serve to optimize delivery of neurotransmitters to the channels. Other findings indicate that the interaction of clustered ligand-gated ion channels with cytoskeletal components may also play a role in channel function. For example, studies suggest that the interaction of microtubules with GABAA receptors regualtes GABA binding affinity. Regulation of neurotransmitter function may be significant in the study of neuropathological processes, such as Alzheimer's disease, neurotrauma, and experimental epilepsy, in which the cytoskeleton is vulnerable to disruption.
Department of Pharmacology, University of Colorado Health Sciences Center, Denver, USA.
V J
VJ
Whatley
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Harris
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D003599:Cytoskeleton / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007473:Ion Channels; D008870:Microtubules / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000378:metabolism; D011963:Receptors, GABA-A / Q000378:metabolism; D017981:Receptors, Neurotransmitter / Q000378:metabolism*
D007473:Ion Channels; D009419:Nerve Tissue Proteins; D011963:Receptors, GABA-A; D017981:Receptors, Neurotransmitter