The natural history of human papillomavirus type 16 capsid antibodies among a cohort of university women.
To study the temporal relationship between serum antibody response and human papillomavirus type 16 (HPV-16) infection, a cohort of 325 university women were scheduled for examinations at 4-month intervals. At every examination, interviews were completed, cells were obtained for polymerase chain reaction-based testing and for Pap screening, and serum was obtained for testing with a HPV-16 capsid-capture ELISA. Seroreactivity was associated with detection of HPV-16 DNA and with increased numbers of sex partners. The median time to seroconversion was 8.3 months among women with incident HPV-16 infections. Within 16 months following HPV-16 DNA detection, 93.7% of women with prevalent and 67.1% of women with incident infections seroconverted. After seroconversion, antibody responses were maintained during follow-up among HPV-16 DNA-positive women. Women who seroconverted were 5.7 times (95% confidence interval = 2.4-13.4) more likely to have squamous intraepithelial lesions associated with the detection of HPV-16 DNA than were women who did not seroconvert.
Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA.
J J
JJ
Carter
L A
LA
Koutsky
G C
GC
Wipf
N D
ND
Christensen
S K
SK
Lee
J
J
Kuypers
N
N
Kiviat
D A
DA
Galloway
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D002213:Capsid / Q000276:immunology*; D015331:Cohort Studies; D004279:DNA, Viral / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D027383:Papillomaviridae / Q000235:genetics / Q000276:immunology*; D030361:Papillomavirus Infections / Q000276:immunology*; D014412:Tumor Virus Infections / Q000276:immunology*; D002583:Uterine Cervical Neoplasms / Q000821:virology
D000914:Antibodies, Viral; D004279:DNA, Viral