Successful treatment with cyclosporin A of pure red cell aplasia associated with rheumatoid arthritis.
We describe the first report of a patient with rheumatoid arthritis (RA) who developed refractory pure red cell aplasia that was successfully treated with cyclosporin A (CyA). Since no inhibitory activity against bone marrow was observed in the whole serum, it is possible that the clinical efficacy of CyA on both RA and aplasia was explained by its effects on T cells that might be involved in the development of these diseases.
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
T
T
Fujii
T
T
Yajima
H
H
Kameda
T
T
Mimori
M
M
Akizuki
Y
Y
Ikeda
D001172:Arthritis, Rheumatoid / Q000150:complications*; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D012010:Red-Cell Aplasia, Pure / Q000150:complications / Q000188:drug therapy*; D017701:Reticulocyte Count / Q000187:drug effects
D006454:Hemoglobins; D016572:Cyclosporine