Hormone replacement therapy and cardiovascular risk in post-menopausal women with NIDDM.
Female patients with NIDDM have a high prevalence of, and mortality from, coronary heart disease (CHD). Hormone replacement therapy (HRT) may favourably influence several CHD risk factors in post-menopausal NIDDM patients, including dyslipidaemia, hypertension, prothrombotic changes, and endothelial dysfunction. Insulin resistance appears to have a central role in the pathogenesis of these abnormalities and can also be modified by HRT. However, the potentially beneficial effects of HRT in women with NIDDM have been extrapolated from the results of studies in non-diabetic females, as to date there have been few studies in NIDDM patients. In view of their excessive CHD mortality, further research is needed to investigate the effects of different HRT preparations on lipid and non-lipid risk factors in this high-risk population.
Department of Pathological Biochemistry, Royal Infirmary, Glasgow, UK.
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Sattar
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Jaap
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MacCuish
D001779:Blood Coagulation Factors / Q000502:physiology; D001792:Blood Platelets / Q000502:physiology; D000075202:Contraindications; D003327:Coronary Disease / Q000453:epidemiology* / Q000401:mortality; D003924:Diabetes Mellitus, Type 2; D003925:Diabetic Angiopathies / Q000453:epidemiology* / Q000401:mortality; D004730:Endothelium, Vascular / Q000503:physiopathology; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D007333:Insulin Resistance; D017698:Postmenopause; D015995:Prevalence; D012307:Risk Factors; D013927:Thrombosis / Q000453:epidemiology / Q000503:physiopathology
D001779:Blood Coagulation Factors