Attenuation by nicotinamide of the streptozocin induced early hyperglycaemia in fasting rats.
The effect of nicotinamide on the streptozocin induced early hyperglycaemia in 48-hour fasted rats was investigated. It was shown that 240 or 400 mg/kg nicotinamide significantly attenuated the streptozocin induced early hyperglycaemia. Nicotinamide should be administered no later than 1 hour after the streptozocin administration. Lower level doses of nicotinamide such as 80 mg/kg were unable to attenuate the streptozocin induced early hyperglycaemia. The possibility of nicotinamide offsetting the streptozocin effect was discussed.
Department of Pharmacology, National Yang Ming University Taipei, Taiwan, Republic of China.
K K
KK
Wong
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D005215:Fasting; D006943:Hyperglycemia / Q000139:chemically induced* / Q000188:drug therapy / Q000517:prevention & control*; D008297:Male; D009536:Niacinamide / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin / Q000633:toxicity*
D000903:Antibiotics, Antineoplastic; D009536:Niacinamide; D013311:Streptozocin