Plasma concentrations of different local anesthetics after facial nerve block.
OBJECTIVE
The authors studied the plasma concentrations of several anesthetics to determine the relative safety of facial blocks as reflected by each anesthetic's kinetics.


METHODS
Seventy-five patients undergoing cataract extraction received a proximal block of a facial nerve using prilocaine, lidocaine, mepivacaine, bupivacaine, or etidocaine.


RESULTS
Mean plasma concentrations were significantly lower after the administration of prilocaine than they were after the administration of lidocaine and mepivacaine (P < .0008; multivariate analysis of variance, Roy's max root). Plasma concentrations of lidocaine and mepivacaine or bupivacaine and etidocaine did not differ from each other. Mean plasma concentrations of prilocaine, lidocaine, and mepivacaine increased continuously for 15 to 22 minutes, whereas mean plasma concentrations of bupivacaine and etidocaine peaked after 10 and 9 minutes, respectively. Peak plasma concentrations of anesthetics were well below toxic levels in all patients.


CONCLUSIONS
Although systemic toxicity resulting from the rapid absorption of local anesthetics after facial nerve block seems unlikely, prilocaine may be the anesthetic most preferred for such a block because of its high level of safety.
Department of Anesthesiology, Eberhard-Karls-University, Tübingen, Germany.
F
F
Schimek
D
D
Friess
M
M
Fable
D000042:Absorption; D000368:Aged; D000369:Aged, 80 and over; D000772:Anesthesia, Local / Q000379:methods; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000097:blood*; D002387:Cataract Extraction; D002851:Chromatography, High Pressure Liquid; D005154:Facial Nerve / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009407:Nerve Block; D009883:Ophthalmic Solutions; D011446:Prospective Studies
D000779:Anesthetics, Local; D009883:Ophthalmic Solutions