Absence of significant hemodynamic changes in the fetus following maternal betamethasone administration.
Maternal betamethasone administration causes a transient but considerable reduction in fetal body and breathing movements and in fetal heart rate variation. The aim of the present prospective study was to investigate whether there is evidence of circulatory changes in fetal, placental or uterine arteries, consistent with hypoxemia. Eighteen women at risk for preterm delivery received betamethasone to enhance fetal lung maturation. Doppler studies were performed before treatment, and 24 and 72 h after the second dose of betamethasone. Blood flow velocity waveforms were obtained from both uterine arteries, umbilical arteries, fetal descending aorta, fetal renal artery, and fetal cerebral arteries. No significant changes occurred in the pulsatility index of any of these blood vessels, suggesting that the transient reduction in fetal heart rate variation and fetal body and breathing movements following maternal betamethasone administration is not mediated through fetal hypoxemia.
Department of Obstetrics and Gynecology, University Hospital, Utrecht, The Netherlands.
B J
BJ
Cohlen
R H
RH
Stigter
J B
JB
Derks
E J
EJ
Mulder
G H
GH
Visser
D000328:Adult; D001623:Betamethasone / Q000008:administration & dosage*; D001783:Blood Flow Velocity / Q000187:drug effects; D005260:Female; D005324:Fetal Movement / Q000187:drug effects; D005333:Fetus / Q000098:blood supply* / Q000187:drug effects; D005865:Gestational Age; D005938:Glucocorticoids / Q000008:administration & dosage*; D006340:Heart Rate, Fetal / Q000187:drug effects; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D007273:Injections, Intramuscular; D011247:Pregnancy; D011446:Prospective Studies; D012119:Respiration / Q000187:drug effects; D012307:Risk Factors; D018608:Ultrasonography, Doppler / Q000379:methods; D016216:Ultrasonography, Prenatal / Q000379:methods; D014469:Umbilical Arteries / Q000000981:diagnostic imaging* / Q000187:drug effects
D005938:Glucocorticoids; D001623:Betamethasone