Sparteine metabolism in a Nigerian population.
The oxidative metabolism of sparteine has been investigated in a Nigerian population. The distribution of metabolic capacities was shown to be skewed with two subjects (2/97, 2.1%) being relatively deficient in their ability to produce the dehydrometabolites. These observations afford evidence that sparteine oxidation is under polymorphic control in Nigerians.
Ritchie
J C
JC
Imperial College School of Medicine at St. Mary's, London, U.K.
Mitchell
S C
SC
Smith
R L
RL
D000328:Adult; D002855:Chromatography, Thin Layer; D005260:Female; D006801:Humans; D008297:Male; D009549:Nigeria; D010084:Oxidation-Reduction; D010783:Photometry; D011110:Polymorphism, Genetic; D013034:Sparteine / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine
D013034:Sparteine; C044694:2-dehydrosparteine