Hepatotoxic side-effect of clomethiazole.
We report on a patient with a history of alcoholism who developed hyperbilirubinemia induced by treatment with clomethiazole during two hospitalizations. After discontinuation of clomethiazole symptoms of cholestasis improved. Clomethiazole is a thiazole analogon and is chemically related to thiamine (vitamin B1). It can be administered as tablets, capsules, mixtures, and a 0.8% solution. Because of its sedative, hypnotic, and anti-convulsive effects it is used in the treatment of alcoholic delirium.
Heinemann
F
F
Department of Neurology, St-Josef-Hospital, Moers, Germany.
Assion
H J
HJ
D000430:Alcohol Withdrawal Delirium / Q000188:drug therapy / Q000523:psychology; D000437:Alcoholism / Q000150:complications; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D002719:Chlormethiazole / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged
D000927:Anticonvulsants; D002719:Chlormethiazole