Beta-endorphin but not metenkephalin counteracts adenosine-provoked angina pectoris-like pain.
Whether i.v. infusion of beta-endorphin or metenkephalin can modify adenosine-provoked angina pectoris-like pain was investigated in healthy volunteers with a double-blind controlled design. All seven volunteers experienced dose-related adenosine-provoked chest pain. Metenkephalin did not modulate the dose-effect curve for adenosine while beta-endorphin counteracted (p < 0.01) the development of pain. The results suggest that peripheral p.subtype opioid receptors are involved in the modulation and may play a role in the genesis of silent and painful myocardial ischaemia.
Karolinska Institute, Department of Medicine, Huddinge University Hospital, Sweden.
C
C
Sylvén
B
B
Eriksson
D S
DS
Sheps
B
B
Maixner
D000328:Adult; D000787:Angina Pectoris / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004745:Enkephalins / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy*; D001615:beta-Endorphin / Q000627:therapeutic use*
D004745:Enkephalins; D001615:beta-Endorphin