Recent developments in cerebral monitoring--near-infrared light spectroscopy. An overview.
A recent development has been the resurgence of interest in the concept of near-infrared light spectroscopy as a method of monitoring cerebral perfusion. Although this technique has been in use for 40 years, the principle has been primarily employed in peripheral pulse oximetry. Infrared light of wavelengths 600-1300 nanometres (nm) penetrate human tissue to a depth of several centimetres. Within the human brain this light is attenuated by the chromophores oxyhaemoglobin, deoxyhaemoglobin and also oxidised cytochrome a3. Positioning a near-infrared light source and a photodetector in a side by side configuration detects light attenuated and reflected in a parabolic path through the scalp, skull and brain tissue.
Department of Surgery, University Hospital of South Manchester, West Didsbury, Manchester, U.K.
I M
IM
Williams
A J
AJ
Mortimer
C N
CN
McCollum
D001921:Brain / Q000378:metabolism; D002560:Cerebrovascular Circulation; D003576:Electron Transport Complex IV / Q000097:blood; D004867:Equipment Design; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008991:Monitoring, Physiologic / Q000295:instrumentation; D010092:Oximetry; D010100:Oxygen / Q000097:blood; D010108:Oxyhemoglobins / Q000032:analysis; D012535:Scalp; D012886:Skull; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation / Q000379:methods
D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin; D003576:Electron Transport Complex IV; D010100:Oxygen