Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin HCl in man.
The pharmacokinetics of four single-dose treatments of the metformin administered orally (as the HCl salt) were compared in 24 healthy subjects: 500 mg and 850 mg tablets and 850 mg solution fasting and 850 mg tablet with food. Solution and tablet formulations are bioequivalent. Bioavailability of a 500 mg tablet is 14% greater than that of an 850 mg tablet. Compared with the fasting state, bioavailability is 24% lower, and the peak concentration delayed about 37 min when an 850 mg tablet is administered with food.
Sambol
N C
NC
Department of Biopharmaceutical Sciences, University of California, San Francisco 94143-0446, USA.
Brookes
L G
LG
Chiang
J
J
Goodman
A M
AM
Lin
E T
ET
Liu
C Y
CY
Benet
L Z
LZ
D000328:Adult; D000704:Analysis of Variance; D004305:Dose-Response Relationship, Drug; D002149:Energy Intake; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007408:Intestinal Absorption; D008297:Male; D008687:Metformin / Q000008:administration & dosage / Q000493:pharmacokinetics*
D007004:Hypoglycemic Agents; D008687:Metformin