Subcutaneously implanted tumour: an hypothesized novel approach to individualized immunotherapy for lung carcinoma.
A novel approach to immunotherapy for the treatment of lung carcinoma is hypothesized. If a lung tumour removed at operation is implanted subcutaneously within a Millipore chamber in that patient, then a local immune response may be induced. It is suggested that this subcutaneously induced immune response could improve the prognosis of the underlying tumour either of its own accord or by its use as an adoptive immunotherapy. Spread of the tumour locally would be prevented by containment within the Millipore chamber. The hypothesis has been supported by experimental observations from a pilot study.
Department of Cardiothoracic Surgery, St Bartholomew's Hospital, London, UK.
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D000818:Animals; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D018448:Models, Immunological; D009368:Neoplasm Transplantation / Q000276:immunology / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic