Normal and abnormal pulmonary ventilation: visualization at hyperpolarized He-3 MR imaging.
To assess the feasibility of helium-3 magnetic resonance (MR) imaging with a three-dimensional fast low-angle shot (FLASH) sequence, He-3 gas (volume, 300 mL; pressure, 3 x 10(5) Pa; polarized up to 45% by means of optimal pumping) was inhaled by five healthy volunteers and five patients with pulmonary diseases. All breath-hold examinations (22-42 seconds) were completed successfully. Normal ventilation was depicted with homogeneous high signal intensity, lesions were depicted as causing defects, and obstructive lung disease was depicted with severely inhomogeneous signal intensity.
Department of Radiology, Johannes Gutenberg-Universität Mainz, Germany.
H U
HU
Kauczor
D
D
Hofmann
K F
KF
Kreitner
H
H
Nilgens
R
R
Surkau
W
W
Heil
A
A
Potthast
M V
MV
Knopp
E W
EW
Otten
M
M
Thelen
D000280:Administration, Inhalation; D000328:Adult; D001980:Bronchi / Q000033:anatomy & histology / Q000473:pathology; D006371:Helium; D006801:Humans; D007554:Isotopes; D008168:Lung / Q000033:anatomy & histology / Q000473:pathology* / Q000502:physiology; D008171:Lung Diseases / Q000175:diagnosis* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D012119:Respiration; D014132:Trachea / Q000033:anatomy & histology / Q000473:pathology
D007554:Isotopes; D006371:Helium