The effect of a very low dose of tolbutamide combined with an alpha-glucosidase inhibitor in non-insulin-dependent diabetes mellitus.
The effect of adding a very low dose of a sulphonylurea (tolbutamide) to the treatment of 10 patients with noninsulin-dependent diabetes mellitus (NIDDM) was investigated. Patients took 0.1 mg tds of an alpha-glucosidase inhibitor orally for 8 weeks, and 50 mg tds of the sulphonylurea, tolbutamide, for the last 4 weeks of this period. The glycosylated haemoglobin level was significantly reduced during the combined treatment period compared with the level after treatment with alpha-glucosidase inhibitor alone (P = 0.035), although not compared with the pretreatment level. There were no significant changes in post-prandial blood glucose, serum lipid levels or connective peptide immunoreactivities. These preliminary results indicate that the addition of a very low dose of tolbutamide to a recommended diet and treatment with an alpha-glucosidase inhibitor, may improve glucose metabolism without raising insulin secretion or influencing lipid metabolism.
Third Department of Medicine, Okayama University Medical School, Japan.
S
S
Okada
K
K
Ishii
H
H
Hamada
S
S
Tanokuchi
K
K
Ichiki
Z
Z
Ota
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003238:Connective Tissue / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000008:administration & dosage*; D006442:Glycated Hemoglobin / Q000378:metabolism; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007150:Immunohistochemistry; D007294:Inositol / Q000008:administration & dosage / Q000031:analogs & derivatives; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D010455:Peptides / Q000378:metabolism; D014044:Tolbutamide / Q000008:administration & dosage*
D001786:Blood Glucose; D004791:Enzyme Inhibitors; D006442:Glycated Hemoglobin; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D007294:Inositol; D008055:Lipids; D010455:Peptides; D014044:Tolbutamide; C009862:connective tissue-activating peptide; C102817:voglibose