[Pathogenesis of lung damage caused by Pasteurella haemolytica].
Pneumonic pasteurellosis is the major economic problem of the cattle industry in North America. This disease is characterized by an acute, severe, fibrinonecrotic pleuropneumonia. Pasteurella haemolytica A1 is commonly isolated from these pneumonic lesions. It has been demonstrated that stress or viral infection compromises defense mechanisms of the upper respiratory tract and lung, predisposing to an initial multiplication of bacteria in the nasopharynx and, subsequently, lungs are deluged with large numbers of bacteria. Once multiplication in the alveoli has begun, virulence factors exert their influence to induce an excessive host inflammatory response that results in severe tissue damage. Despite a large number of studies conducted to explore the complex interaction between P. haemolytica and the host response, there still remains a lack of detailed understanding. This review discusses evidence of the role of the main virulence factors of P. haemolytica on the pathogenesis of pulmonary damage.
Departamento de Patología de la Facultad de Medicina Veterinaria y Zootecnia de la Universidad Autónoma de Nuevo León, Monterrey, Mexico.
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Ramírez-Romero
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Brogden
D000818:Animals; D016667:Bacterial Capsules / Q000009:adverse effects; D001426:Bacterial Proteins / Q000009:adverse effects; D001427:Bacterial Toxins / Q000009:adverse effects; D001779:Blood Coagulation Factors / Q000378:metabolism; D002417:Cattle; D016207:Cytokines / Q000378:metabolism; D004798:Enzymes / Q000009:adverse effects; D005098:Exotoxins / Q000009:adverse effects; D008168:Lung / Q000382:microbiology / Q000473:pathology*; D016676:Macrophages, Alveolar / Q000502:physiology; D016978:Mannheimia haemolytica / Q000145:classification / Q000302:isolation & purification / Q000472:pathogenicity*; D009305:Nasopharynx / Q000382:microbiology; D009336:Necrosis; D009504:Neutrophils / Q000502:physiology; D012766:Pasteurellosis, Pneumonic / Q000382:microbiology / Q000473:pathology*; D014774:Virulence
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D001779:Blood Coagulation Factors; D016207:Cytokines; D004798:Enzymes; D005098:Exotoxins; C018579:leukotoxin; C045072:macrophage procoagulant activity