Radioiodinated metaiodobenzylguanidine scintigraphy for pheochromocytoma. A false-positive case of adrenocortical adenoma and literature review.
Radioiodinated metaiodobenzylguanidine (MIBG) scintigraphy is known for its high specificity in detecting pheochromocytoma and other tumors of neural crest origin. We describe herein the first case of a definite adrenocortical adenoma that demonstrated false-positive uptake on MIBG scintigraphy. In addition, we reviewed all 13 reported cases showing false-positive uptake, and suggest that careful evaluation is needed before diagnosing a 'silent' or 'asymptomatic' pheochromocytoma.
Department of Endocrinology and Metabolism, University of Tsukuba, Ibaraki, Japan.
H
H
Sone
Y
Y
Okuda
Y
Y
Nakamura
N
N
Ishikawa
T
T
Yamaoka
Y
Y
Kawakami
M
M
Odawara
T
T
Matsushima
K
K
Kawai
K
K
Yamashita
D019797:3-Iodobenzylguanidine; D000236:Adenoma / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D000328:Adult; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D010673:Pheochromocytoma / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D011877:Radionuclide Imaging; D014057:Tomography, X-Ray Computed
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine