[Ca2+ -ATPase].
The importance of the Ca2+ -ATPases of the surface and endoplasmic reticulum membranes in regulating the intracellular Ca2+ concentrations in living cells has been recognized as a result of the development of biophysical techniques and finding of useful pharmacological tool drugs. The number of possible isoforms of these Ca2+ -ATPases are increased by a complex pattern of alternative splicing and the knowledge of the functional difference and tissue distribution of these isoforms has been accumulated. In this review, we discuss recent progress in our understanding of the roles of the Ca2+ -ATPases in physiological and pathophysiological conditions.
Department of Pharmaceutical Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku University, Japan.
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Furukawa
D000818:Animals; D002118:Calcium / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000378:metabolism
D000252:Calcium-Transporting ATPases; D002118:Calcium