Tissue regeneration as the basic oncogenic factor.
A new hypothesis of oncogenesis has been suggested. The errors of deoxyribonucleic acid (DNA) synthesis are supposed to be the main cause of oncogenic mutations. Since cell division and consequently DNA synthesis are continually needed for the renewal of some tissues in adult organisms, the physiological and reparative regeneration of these tissues (epithelium, blood) is the basic factor of oncogenesis. The exogenous and endogenous agents increase the probability of tumor frequency via increasing the cell renovation rate in tissues and decreasing the DNA synthesis fidelity. This hypothesis is in accord with the experimental and epidemiological data including the results which are not explained reasonably until now, namely, the association of the carcinogenic activity of drugs with their toxicity, the organ and tissue specificity of tumor frequency, etc.
Institute of Theoretical and Experimental Biophysics Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
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Korystov
D000818:Animals; D002471:Cell Transformation, Neoplastic; D003043:Cocarcinogenesis; D004261:DNA Replication / Q000235:genetics; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics; D012038:Regeneration / Q000502:physiology*