Two novel genital human papillomavirus (HPV) types, HPV68 and HPV70, related to the potentially oncogenic HPV39.
The genomes of two novel human papillomavirus (HPV) types, HPV68 and HPV70, were cloned from a low-grade cervical intraepithelial neoplasia and a vulvar papilloma, respectively, and partially sequenced. Both types are related to HPV39, a potentially oncogenic virus. HPV68 and HPV70 were also detected in genital intraepithelial neoplasia from three patients and one patient, respectively. Comparison with sequence data in the literature indicates that the subgenomic ME180-HPV DNA fragment, cloned from a carcinoma cell line, corresponds to an HPV68 subtype and that several HPV DNA fragments amplified by PCR from genital neoplasia represent worldwide distributed variants of HPV68 and HPV70.
Unite Mixte Institut Pasteur (Unite des Papillomavirus)-Institut National de la Sante et de la Recherche Medicale, Paris, France.
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Longuet
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Beaudenon
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D001483:Base Sequence; D003001:Cloning, Molecular; D005260:Female; D016679:Genome, Viral; D006801:Humans; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics / Q000472:pathogenicity; D015183:Restriction Mapping; D002583:Uterine Cervical Neoplasms / Q000821:virology*; D014846:Vulvar Neoplasms / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000821:virology*