Subregional mapping of the human lymphocyte prolyl oligopeptidase gene (PREP) to human chromosome 6q22.
Prolyl oligopeptidase is a large monomeric proline specific serine endopeptidase, the activity of which correlates well with different stages of depression. We have subregionally mapped human lymphocytic prolyl oligopeptidase (PREP) by FISH using a cosmid probe. The probe mapped to the long arm of chromosome 6, and the signal clustered in band q22.
Goossens
F J
FJ
Department of Clinical Biochemistry, University of Antwerp, Wilrijk, Belgium.
Wauters
J G
JG
Vanhoof
G C
GC
Bossuyt
P J
PJ
Schatteman
K A
KA
Loens
K
K
Scharpé
S L
SL
D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D003360:Cosmids; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008214:Lymphocytes / Q000201:enzymology / Q000648:ultrastructure; D016133:Polymerase Chain Reaction; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases / Q000235:genetics*
D012697:Serine Endopeptidases; C000705287:PREPL protein, human; D000085822:Prolyl Oligopeptidases