Immunohistochemical characteristics of the constituents of senile plaques and amyloid angiopathy in aged cynomolgus monkeys.
In this study, we immunohistochemically examined the several constituents of senile plaques (SPs) and cerebral amyloid angiopathy (CAA) in aged cynomolgus monkeys. Apolipoprotein E (apoE) deposited in all mature plaques and CAA, and in half of the diffuse plaques. Alpha-1-antichymotripsin (alpha ACT) deposited in half of the mature plaques and in one third of the CAA. Amyloid precursor protein (APP), ubiquitin (Ub), and microtubule-associated protein-2 (MAP-2) accumulated in the swollen neurites of mature plaques. Glial fibrillary acidic protein (GFAP) was detected in the astrocytes and their processes surrounding the mature plaques. Tau was detected in neither the SPs nor CAA. Therefore, mature plaques involved extracellular A beta, apoE, and alpha ACT, and also astrocytes and swollen neurites. However, diffuse plaques involved only extracellular A beta and apoE. Since these features, except for tau, were consistent with those in humans, this animal model will be useful for studying the pathogenesis of cerebral amyloid deposition.
Department of Veterinary Pathology, Faculty of Agriculture, University of Tokyo, Japan.
S
S
Nakamura
W
W
Kiatipattanasakul
H
H
Nakayama
F
F
Ono
I
I
Sakakibara
Y
Y
Yoshikawa
N
N
Goto
K
K
Doi
D000375:Aging; D016564:Amyloid beta-Protein Precursor / Q000032:analysis; D000818:Animals; D001057:Apolipoproteins E / Q000032:analysis; D001253:Astrocytes / Q000473:pathology; D001921:Brain / Q000473:pathology*; D016657:Cerebral Amyloid Angiopathy / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008252:Macaca fascicularis; D008297:Male; D008869:Microtubule-Associated Proteins / Q000032:analysis; D016501:Neurites / Q000473:pathology; D014452:Ubiquitins / Q000032:analysis; D000514:alpha 1-Antichymotrypsin / Q000032:analysis
D016564:Amyloid beta-Protein Precursor; D001057:Apolipoproteins E; D005904:Glial Fibrillary Acidic Protein; D008869:Microtubule-Associated Proteins; D014452:Ubiquitins; D000514:alpha 1-Antichymotrypsin