Phospholipases: in search of a genetic base of schizophrenia.
Evidence from a variety of clinical and biochemical sources indicates alterations in phospholipid synthesis and activity in schizophrenia. We review a recent study which suggests that a genetic variant near the promotor region of the gene for cytosolic phospholipase A2, the rate-limiting enzyme in the synthesis of prostaglandins from arachidonic acid (AA), is associated with schizophrenia. These findings are consistent with a extensive body of literature which suggests alterations in membrane phospholipids in schizophrenia.
Schizophrenia Program, Clarke Institute of Psychiatry, Toronto, Ontario, Canada. hudsonc@cs.clarke-inst.on.ca
C J
CJ
Hudson
A
A
Lin
D F
DF
Horrobin
D000483:Alleles; D015331:Cohort Studies; D003600:Cytosol / Q000737:chemistry; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism*; D010740:Phospholipases / Q000235:genetics*; D012016:Reference Values; D012559:Schizophrenia / Q000235:genetics* / Q000378:metabolism
D008563:Membrane Lipids; D010740:Phospholipases