High-dose streptokinase therapy with three million units in one hour significantly improves early coronary patency rates in acute myocardial infarction.
In a prospective, randomized open trial, significantly higher patency rates were observed 60 minutes after beginning fibrinolytic therapy for acute myocardial infarction after administration of 3 million U streptokinase as compared to 1.5 million U (Thrombolysis in Myocardial Infarction [TIMI] grade 2 and 3 in 52% vs 26%; p = 0.04). Adverse events were observed with similar frequency in both groups.
Medizinische Klinik der Technischen Universität München, Germany.
W
W
Theiss
U
U
Busch
U
U
Renner
H
H
Blömer
D000328:Adult; D000368:Aged; D001794:Blood Pressure; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D011446:Prospective Studies; D013300:Streptokinase / Q000008:administration & dosage*; D014654:Vascular Patency / Q000187:drug effects*
D013300:Streptokinase