Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search.
Despite its high prevalence, very little is known regarding genetic predisposition to prostate cancer. A genome-wide scan performed in 66 high-risk prostate cancer families has provided evidence of linkage to the long arm of chromosome 1 (1q24-25). Analysis of an additional set of 25 North American and Swedish families with markers in this region resulted in significant evidence of linkage in the combined set of 91 families. The data provide strong evidence of a major prostate cancer susceptibility locus on chromosome 1.
Smith
J R
JR
National Center for Human Genome Research, National Institutes of Health, Bethesda, MD, USA. jtrent@nchgr.nih.gov
Freije
D
D
Carpten
J D
JD
Grönberg
H
H
Xu
J
J
Isaacs
S D
SD
Brownstein
M J
MJ
Bova
G S
GS
Guo
H
H
Bujnovszky
P
P
Nusskern
D R
DR
Damber
J E
JE
Bergh
A
A
Emanuelsson
M
M
Kallioniemi
O P
OP
Walker-Daniels
J
J
Bailey-Wilson
J E
JE
Beaty
T H
TH
Meyers
D A
DA
Walsh
P C
PC
Collins
F S
FS
Trent
J M
JM
Isaacs
W B
WB
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D018900:Dinucleotide Repeats; D005796:Genes; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008875:Middle Aged; D009656:North America; D009857:Oncogenes; D010375:Pedigree; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors; D018709:Statistics, Nonparametric; D013548:Sweden
D005819:Genetic Markers