G protein coupled R7G receptors.
We summarize here a number of properties that have been described for G protein coupled membrane receptors. These concern structure-function relationship, regulation of expression and activity and linkage with pathology. The existence of subfamilies and subtypes is discussed in terms of evolution and selectivity. A comparison is made between binding sites for small ligands such as monoamines and larger ligands such as peptides and glycohormones. Cross-talk of G protein coupled receptors with receptor tyrosine kinase pathways is also discussed. Finally, the role of mutations in modulating receptor activity is evaluated with respect to human disease.
Laboratoire d'Immuno-Pharmacologie Moléculaire, CNRS, Université Paris 7 Denis Diderot.
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Strosberg
D000595:Amino Acid Sequence; D000818:Animals; D019204:GTP-Binding Proteins; D005786:Gene Expression Regulation; D006801:Humans; D008969:Molecular Sequence Data; D011956:Receptors, Cell Surface; D015398:Signal Transduction
D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins