Comparative pharmacokinetics and tissue distribution of norfloxacin-glycine acetate in flounder, (Paralichthys olivaceus) at two different temperatures.
The pharmacokinetics of norfloxacin-glycine acetate (NFXGA), a newly formulated norfloxacin, was investigated in healthy flounders at two different seawater temperature (at 12 degrees C and 20 degrees C) varying concentrations (100 ppm and 10 ppm), using dipping administration. It was shown that the elimination half-life (T1/2) of norfloxacin at 20 degrees C (10 ppm: 13.95 +/- 1.18 hr, 100 ppm: 11.71 +/- 1.32 hr) was significantly shorter than that at 12 degrees C (10 ppm: 16.61 +/- 1.47 hr, 100 ppm: 16.32 +/- 1.19 hr) in flounders. Mean residence time (MRT) was calculated at 12 degrees C (10 ppm: 194.87 +/- 29.88 hr, 100 ppm: 1,222.37 +/- 161.45 hr) and 20 degrees C (10 ppm: 168.42 +/- 25.85, 100 ppm: 606.14 +/- 122.75 hr). Meanwhile, in the flounder tissue distribution of norfloxacin. It was shown that serum, muscle, kidney, and liver exhibited different elimination half-lives of norfloxacin.
Applied Microbiology Laboratory, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, Republic of Korea.
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SC
Park
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Yun
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TK
Oh
D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D005432:Flounder / Q000378:metabolism*; D024841:Fluoroquinolones; D005998:Glycine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D006207:Half-Life; D009643:Norfloxacin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D013696:Temperature; D014018:Tissue Distribution
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; C106482:norfloxacin-glycine acetate; D009643:Norfloxacin; D005998:Glycine