Synergic influence of Ukrain and protoporphyrin amino acid conjugates on human malignant cell lines.
Simultaneous cytotoxicity of Ukrain and protoporphyrin amino-acid derivatives was tested on four malignant cell lines and the cytotoxic effect after laser irradiation was compared with cytotoxicity of Ukrain and protoporphyrin amino-acid derivatives applied on similar cell lines separately. It was found that Ukrain and protoporphyrin amino-acid derivatives act synergistically as cytotoxic substances on the malignant cell lines.
Brzosko
W J
WJ
Roch Brzosko Memorial Centre for Natural Medicine, Warsaw, Poland.
Graczyk
A
A
Konarski
J
J
Nowicky
J W
JW
D000470:Alkaloids / Q000008:administration & dosage / Q000494:pharmacology*; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D001600:Berberine Alkaloids; D003110:Colonic Neoplasms / Q000188:drug therapy; D004354:Drug Screening Assays, Antitumor; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy*; D010617:Phenanthridines; D010778:Photochemotherapy; D011524:Protoporphyrins / Q000008:administration & dosage / Q000494:pharmacology*; D012513:Sarcoma, Experimental / Q000188:drug therapy; D014407:Tumor Cells, Cultured
D000470:Alkaloids; D000596:Amino Acids; D000970:Antineoplastic Agents; D001600:Berberine Alkaloids; D010617:Phenanthridines; D011524:Protoporphyrins; C060921:ukrain