Chemical mechanisms of formation of DNA-carcinogen adducts, elucidation of potential of adducts for mutagenicity, and mechanisms of polymerase fidelity and mutation in the presence of adducts.
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville TN 37232-0146, USA.
F P
FP
Guengerich
M S
MS
Kim
M
M
Müller
L G
LG
Lowe
D016604:Aflatoxin B1 / Q000633:toxicity; D000818:Animals; D001483:Base Sequence; D002273:Carcinogens; D002471:Cell Transformation, Neoplastic; D018736:DNA Adducts; D004257:DNA Polymerase II / Q000378:metabolism; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D016296:Mutagenesis; D013379:Substrate Specificity
D002273:Carcinogens; D018736:DNA Adducts; D016604:Aflatoxin B1; D004257:DNA Polymerase II; D004259:DNA-Directed DNA Polymerase