Proton MR T2 maps correlate with the citrate concentration in the prostate.
A significant correlation between water T2 relaxation time and citrate concentration in the normal prostate is demonstrated using spatially localized spectroscopy and water T2 maps. These data imply that MR images may be used to infer the concentration of citrate at high spatial resolution. Preliminary results in patients demonstrate that this relationship is maintained in benign prostatic hyperplasia (BPH) and prostatic carcinoma. The determination of citrate concentration and water T2 may aid the differentiation of prostate carcinoma from BPH and normal tissue.
Department of Medical Physics, University of Hull, UK.
G P
GP
Liney
M
M
Lowry
L W
LW
Turnbull
D J
DJ
Manton
A J
AJ
Knowles
S J
SJ
Blackband
A
A
Horsman
D000328:Adult; D002951:Citrates / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000033:anatomy & histology* / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000378:metabolism; D014867:Water / Q000378:metabolism
D002951:Citrates; D014867:Water