Diaphyseal telangiectatic osteosarcoma as a second tumor after bilateral retinoblastomas.
In this report, we describe the clinical, imaging, and pathologic findings in a case of diaphyseal telangiectatic osteosarcoma arising 23 years after successful treatment of bilateral retinoblastomas. To our knowledge, telangiectatic osteosarcoma occurring as a second tumor in this setting, outside the radiation treatment field, has not been previously reported. The association of the RB-1 gene defect with retinoblastomas and other tumors is discussed. Also, the computed tomography and magnetic resonance imaging findings in telangiectatic osteosarcoma are described and discussed.
Brown
M J
MJ
Department of Radiology, University of British Columbia, Vancouver, Canada.
Logan
P M
PM
O'Connell
J X
JX
Janzen
D L
DL
Connell
D G
DG
D000328:Adult; D005134:Eye Neoplasms / Q000601:surgery; D005260:Female; D005266:Femoral Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D012516:Osteosarcoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography; D012175:Retinoblastoma / Q000601:surgery