Inhaled nitric oxide.
The major objective of this lecture is to describe the effects of inhaling low levels of nitric oxide (NO) on the hemodynamic and gas exchange function of both the normal and diseased lung. Considerable attention will be paid to safety and hazards of inhaled NO therapy. During the past few years remarkable progress has been made in understanding the NO-guanylate cyclase signal transduction system. NO has been given considerable clinical investigation in pulmonary artery hypertension and the adult respiratory distress syndrome (ARDS) patients. This lecture concentrates on this area of clinical research.
Zapol
W M
WM
Massachusetts General Hospital, Boston 02114, USA.
D000280:Administration, Inhalation; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D006162:Guanylate Cyclase / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy; D008168:Lung / Q000098:blood supply / Q000187:drug effects; D008171:Lung Diseases / Q000188:drug therapy; D009569:Nitric Oxide / Q000008:administration & dosage / Q000009:adverse effects / Q000502:physiology / Q000627:therapeutic use*; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000187:drug effects; D011651:Pulmonary Artery; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D012128:Respiratory Distress Syndrome / Q000188:drug therapy; D012449:Safety; D015398:Signal Transduction / Q000502:physiology; D014655:Vascular Resistance / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use
D014665:Vasodilator Agents; D009569:Nitric Oxide; D006162:Guanylate Cyclase; D010100:Oxygen