Biophysical characterization and formulation of TP40: A chimeric protein that requires a pH-dependent conformational change for its biological activity.
Department of Vaccine Pharmaceutical Research, Merck Research Laboratories, West Point, Pennsylvania 19486, USA.
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Sanyal
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Marquis-Omer
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Middaugh
D036002:ADP Ribose Transferases; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001427:Bacterial Toxins / Q000737:chemistry / Q000494:pharmacology; D005098:Exotoxins / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D011487:Protein Conformation; D011550:Pseudomonas aeruginosa / Q000378:metabolism; D013329:Structure-Activity Relationship; D016211:Transforming Growth Factor alpha / Q000737:chemistry* / Q000494:pharmacology*; D037521:Virulence Factors; D000097668:Pseudomonas aeruginosa Exotoxin A
D036002:ADP Ribose Transferases; D000970:Antineoplastic Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D016211:Transforming Growth Factor alpha; D037521:Virulence Factors; D000097668:Pseudomonas aeruginosa Exotoxin A; C083452:transforming growth factor alpha-Pseudomonas exotoxin A (40)