Monitoring antihypertensive therapy through blood pressure measurements taken casually, at rest, during exercise, and under outpatient conditions.
To ensure a high degree of patient compliance, and thus, therapeutic safety also, an antihypertensive agent should lower blood pressure for 24 h when taken once a day. A placebo-controlled investigation was carried out in 22 patients with essential arterial hypertension, to ascertain whether this was the case with once daily administration of ramipril. Blood pressure was measured at rest, during exercise, and under outpatient conditions (ambulant blood pressure measurement-ABPM). In our study, ramipril had an excellent 24-h effect and was found to be suitable for administration once a day. ABPM represents the most comprehensive and reliable means of monitoring antihypertensive treatment, particularly since it also provides data about nocturnal blood pressure behavior and additionally enables the most distinctive determination of the trough to peak-ratio.
Innere Medizin I, Krankenhaus Neukölln, Berlin.
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Hammerschmidt
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Schaaf
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Lohmann
D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D015924:Blood Pressure Monitors; D002940:Circadian Rhythm / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005080:Exercise Test / Q000187:drug effects*; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D017257:Ramipril / Q000008:administration & dosage*; D015203:Reproducibility of Results
D000959:Antihypertensive Agents; D006852:Hydrochlorothiazide; D017257:Ramipril