Bilateral lobar transplantation utilizing living related donors.
As the recipient list for patients requiring lung transplantation continues to increase, cadaveric donor lung availability has remained static. Our experience with utilizing lobes from living related donors for bilateral pulmonary transplantation in 20 patients has yielded a 75% survival at 1 year follow-up. Morbidity and mortality have been predominately due to infection. Rejection episodes have been mild and unilateral and have responded to augmented corticosteroids. Pulmonary function tests in the recipients tend to improve steadily during the first year postoperatively, and the patients have excellent functional capacity. There have been no significant complications in the donors. On the basis of our clinical experience, we have found that bilateral lobar transplantation utilizing living related donors has resulted in organ availability that can be lifesaving in critically ill patients and can provide a good alternative in certain noncritical, deteriorating patients.
Division of Cardiothoracic Surgery, University of Southern California School of Medicine, Los Angeles 90033-4612, USA.
M L
ML
Barr
F A
FA
Schenkel
R G
RG
Cohen
K M
KM
Chan
C C
CC
Marboe
J A
JA
Hagen
R G
RG
Barbers
V A
VA
Starnes
D000293:Adolescent; D000328:Adult; D003550:Cystic Fibrosis / Q000401:mortality / Q000601:surgery*; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D007398:Interpersonal Relations; D016040:Lung Transplantation / Q000401:mortality / Q000592:standards / Q000639:trends; D011183:Postoperative Complications / Q000401:mortality; D014019:Tissue Donors
D007166:Immunosuppressive Agents