In vitro anti-Mycobacterium avium activity of N-(2-hydroxyethyl)-1,2-benzisothiazol-3(2H)-one and -thione carbamic esters.
A series of N-(2-hydroxyethyl)-1,2-benzisothiazol-3(2H)-one and -thione carbamic esters have been synthesised and tested against Mycobacterium avium strains. The MIC values determined by the radiometric broth dilution method were between 2 and 8 micrograms/mliters for the benzisothiazolthione derivatives and between 16 and 32 micrograms/mliters or higher for the corresponding benzisothiazolone derivatives.
Dipartimento di Chimica Farmaceutica, Università degli Studi, Pavia, Italy.
G
G
Pagani
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P
Borgna
C
C
Piersimoni
D
D
Nista
M
M
Terreni
M
M
Pregnolato
D002219:Carbamates / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009162:Mycobacterium avium / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000494:pharmacology*
D002219:Carbamates; D013844:Thiazoles; C015699:1,2-benzisothiazoline-3-one; C070766:carbamic acid