Live attenuated varicella vaccine.
Varicella-zoster virus (VZV) is a ubiquitous human pathogen that causes varicella, commonly called chicken pox; establishes latency; and reactivates as herpes zoster, referred to as shingles. A live attenuated varicella vaccine, derived from the Oka strain of VZV has clinical efficacy for the prevention of varicella. The vaccine induces persistent immunity to VZV in healthy children and adults. Immunization against VZV also has the potential to lower the risk of reactivation of latent virus. The varicella vaccine may eventually reduce or eliminate herpes zoster, which is a serious problem for elderly and immunocompromised individuals.
Department of Pediatrics and Microbiology/Immunology, Stanford University Medical Center, California 94305, USA.
A M
AM
Arvin
A A
AA
Gershon
D000328:Adult; D002170:Canada / Q000453:epidemiology; D002644:Chickenpox / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D019433:Chickenpox Vaccine / Q000191:economics / Q000627:therapeutic use*; D002648:Child; D006562:Herpes Zoster / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D014481:United States / Q000453:epidemiology; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000191:economics / Q000627:therapeutic use; D017735:Virus Latency
D019433:Chickenpox Vaccine; D014613:Vaccines, Attenuated