Ossifying fibroma of the skull in a patient with neurofibromatosis type 1. Case report.
Ossifying fibroma is a rare, benign, primary bone tumor that occurs most commonly in the mandible; a cranial vault location is extremely rare. In this report a case of symptomatic frontoparietotemporal ossifying fibroma with intracranial growth and cerebral displacement in a 12-year-old boy with neurofibromatosis type 1 (NF1) is described. Once excised the lesion did not recur. The skeletal system is frequently affected in NF1, and bone abnormalities are present in 50% to 70% of patients with this condition. The etiology of such lesions in NF1 is still controversial. To the authors' knowledge, ossifying fibromas of calvarial bones have not been described in NF1.
Ruggieri
M
M
Division of Pediatric Neurology, University of Catania, Italy.
Pavone
V
V
Tiné
A
A
Polizzi
A
A
Magro
G
G
Duray
P H
PH
Merino
M
M
Albanese
V
V
D002648:Child; D018214:Fibroma, Ossifying / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008297:Male; D009456:Neurofibromatosis 1 / Q000000981:diagnostic imaging / Q000473:pathology*; D012888:Skull Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed