Protection against experimental nervous system autoimmune diseases by a human immunodeficiency virus-1 Tat peptide-based polyvalent vaccine.
The human immunodeficiency virus-1 (HIV-1) Tat peptide is taken up by a variety of cells in vitro and in vivo (Anderson et al.: Biochem Biophys Res Commun 194:876-884, 1993; Fawell et al.: Proc Natl Acad Sci USA 91:664-668, 1994; Chen et al.: Anal Biochem 227:168-175, 1995). We have used Tat37-72, the fragment containing a domain binding to alpha v beta 5 integrin (Vogel et al.: J Cell Biol 121:461-468, 1993), to deliver a fusion protein of three pathogenic rat T-cell epitopes, MBP68-84, P2,53-78, and IRBP1169-1191 systemically and via mucoepithelial surfaces. This recombinant polyvalent vaccine peptide, toolbox101, is-depending on the route of administration-specifically immunosuppressive and can be used to vaccinate against experimental autoimmune encephalomyelitis, neuritis, and uveoretinitis and is, in addition, of therapeutic value.
Institute of Brain Research, University of Tübingen, Germany.
H J
HJ
Schluesener
D016915:AIDS Vaccines / Q000627:therapeutic use*; D000595:Amino Acid Sequence; D000818:Animals; D001327:Autoimmune Diseases / Q000517:prevention & control*; D001483:Base Sequence; D002417:Cattle; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D015696:Gene Products, tat / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D009422:Nervous System Diseases / Q000517:prevention & control*; D051381:Rats; D011917:Rats, Inbred Lew; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000627:therapeutic use*; D054322:tat Gene Products, Human Immunodeficiency Virus
D016915:AIDS Vaccines; D018984:Epitopes, T-Lymphocyte; D015696:Gene Products, tat; D014614:Vaccines, Synthetic; D054322:tat Gene Products, Human Immunodeficiency Virus