Large clostridial cytotoxins--a family of glycosyltransferases modifying small GTP-binding proteins.
Some Clostridium species produce ABX-type protein cytotoxins of high molecular weight. These toxins constitute the group of large clostridial cytotoxins (LCTs), which have homologous protein sequences, exert glycosyltransferase activity and modify GTP-binding proteins of the Ras-superfamily. These characteristics render the LCTs valuable tools for developmental and cell biologists.
Institut für Medizinische Mikrobiologie und Hygiene, Johannes Gutenberg-Universítdt Mainz, Germany. veichel@goofy.zdv.uni.mainz.de
C
C
von Eichel-Streiber
P
P
Boquet
M
M
Sauerborn
M
M
Thelestam
D001427:Bacterial Toxins; D003013:Clostridium / Q000737:chemistry*; D003603:Cytotoxins; D016695:Glycosyltransferases / Q000378:metabolism*; D018631:ras Proteins / Q000378:metabolism*
D001427:Bacterial Toxins; D003603:Cytotoxins; D016695:Glycosyltransferases; D018631:ras Proteins