Hemostatic balance during the acute inflammatory reaction. (II). With special reference to plasma protein C.
While plasma fibrinogen level and clotting factor VIII activity obviously increased during the acute inflammatory reaction caused by intramuscular injections of turpentine in 10 rabbits, the activity of plasma protein C, with anticoagulant and antithrombotic effects, was found to display a slight yet significant (p < 0.02) decrease. When compared to protein C activity in humans, this vitamin K-dependent serine protease was found to be lower in rabbits (52, 7% +/- 3,63 of standard human plasma) and this activity decreased to 45,8% +/- 2,80 (mean +/- SEM), 48 hours after the injection of turpentine. This slight decrease should however be interpreted in the context of other disturbances of the hemostatic balance caused by inflammation and may contribute to the intravascular deposition of fibrin.
Department of Physiopathology, University of Medicine and Pharmacy Cluj.
L
L
Plesca
I
I
Brudasca
D
D
Colhon
M
M
Cucuianu
D000210:Acute-Phase Reaction / Q000139:chemically induced / Q000503:physiopathology*; D000818:Animals; D005169:Factor VIII / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006487:Hemostasis / Q000276:immunology*; D006801:Humans; D011486:Protein C / Q000378:metabolism*; D011817:Rabbits; D014425:Turpentine
D011486:Protein C; D005169:Factor VIII; D005340:Fibrinogen; D014425:Turpentine