Genetic risk factors for aPL syndrome.
MHC class II alleles and C4 deficiency alleles have been variably associated with aPL syndrome, but the extensive linkage disequilibrium among many of these alleles has made it difficult to assign a causal role for any of them. Interethnic studies of these and other alleles in large cohorts of subjects would help to clarify the roles of these alleles in aPL syndrome.
Wilson
W A
WA
Department of Rheumatology, Louisiana State University Medical Center, New Orleans 70112-2822, USA.
Gharavi
A E
AE
D000483:Alleles; D016736:Antiphospholipid Syndrome / Q000209:etiology* / Q000235:genetics; D003181:Complement C4 / Q000172:deficiency; D006683:HLA-DQ Antigens / Q000235:genetics; D059866:HLA-DQ beta-Chains; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D012307:Risk Factors
D003181:Complement C4; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D000949:Histocompatibility Antigens Class II