Fast 3D functional magnetic resonance imaging at 1.5 T with spiral acquisition.
A new method to perform rapid 3D fMRI in human brain is introduced and evaluated in normal subjects, on a standard clinical scanner at 1.5 Tesla. The method combines a highly stable gradient echo technique with a spiral scan method, to detect brain activation related changes in blood oxygenation with high sensitivity. A motor activation paradigm with a duration of less than 5 min, performed on 10 subjects, consistently showed significant changes in signal intensity in the area of the motor cortex. In all subjects, these changes survived high statistical thresholds.
Laboratory of Diagnostic Radiology Research, OIR, National Institutes of Health, Bethesda, MD 20892, USA.
Y
Y
Yang
G H
GH
Glover
P
P
van Gelderen
V S
VS
Mattay
A K
AK
Santha
R H
RH
Sexton
N F
NF
Ramsey
C T
CT
Moonen
D R
DR
Weinberger
J A
JA
Frank
J H
JH
Duyn
D001921:Brain / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009044:Motor Cortex / Q000473:pathology