Overall cancer incidence not increased after prosthetic knee replacement: 14,551 patients followed for 66,622 person-years.
It is unknown whether patients as a consequence of prosthetic joint replacement are at a higher risk of developing cancer. We therefore analyzed cancer incidence following prosthetic knee replacement (TKR). The observed cancer incidence in 14,551 patients from the population-based Swedish Knee Arthroplasty Register who have undergone TKR because of osteoarthrosis (OA, n = 10,120) or rheumatoid arthritis (RA, n = 4431) were compared with the expected cancer incidence for a Swedish reference population. The cohort was followed for a total of 66,622 person-years. We followed 33% of the patients with OA and 59% of those with RA for more than 5 years. All patients who underwent TKR, whether for OA or for RA, had lower than expected total cancer incidence. We found a markedly low incidence of colorectal carcinoma, especially in patients with RA. Our results do not indicate an increased incidence of cancer following TKR.
Department of Orthopedics, University Hospital, Lund, Sweden.
S
S
Lewold
H
H
Olsson
P
P
Gustafson
A
A
Rydholm
L
L
Lidgren
D001172:Arthritis, Rheumatoid / Q000601:surgery; D015179:Colorectal Neoplasms / Q000453:epidemiology; D005260:Female; D006801:Humans; D007720:Knee Prosthesis / Q000009:adverse effects*; D008297:Male; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology; D010003:Osteoarthritis / Q000601:surgery; D013548:Sweden; D013997:Time Factors