Differential expression of fructosyllysine-specific receptors on monocytes and macrophages and possible pathophysiological significance.
A differing individual expression of fructosyllysine-specific receptors has been found on the monocytes of 90 insulin-dependent diabetic patients and 101 healthy control subjects. The degree of receptor expression is neither age- nor sex-dependent; however, in the diabetic group it correlates significantly with the severity and age of onset of diabetic microangiopathy. To interpret the results of the human study, spontaneously diabetic and non-diabetic BB/OK rats were used to estimate tissue content of glucose-modified proteins and capillary basement membrane thickness in relation to the receptor expression on macrophages. In non-diabetic and diabetic rats no correlation was found between receptor expression and tissue content (i.e. artery, nerve) of fructosyllsine and fluorescent advanced glycation end products. However, animals which express the fructosyllysine receptor showed a greater increase in muscle capillary basement membrane thickness. There are indications that fructosyllysine receptor expression is positively associated with indices of diabetic complications such as microangiopathy and/or capillary basement membrane thickening.
Institute of Biochemistry, Faculty of Medicine, Ernst Moritz Arndt University, Greifswald, Germany.
R
R
Brandt
C
C
Landmesser
L
L
Vogt
B
B
Hehmke
R
R
Hanschke
J
J
Kasbohm
K
K
Hartmann
B
B
Jäger
S
S
Krantz
D
D
Michaelis
D000328:Adult; D017668:Age of Onset; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000503:physiopathology; D003930:Diabetic Retinopathy / Q000503:physiopathology; D005260:Female; D019270:Fructosamine / Q000097:blood; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D009687:Nuclear Proteins / Q000096:biosynthesis*; D011336:Probability; D016601:RNA-Binding Proteins / Q000096:biosynthesis*; D051381:Rats; D011913:Rats, Inbred BB; D012016:Reference Values
D001786:Blood Glucose; D019270:Fructosamine; D006442:Glycated Hemoglobin; D008239:Lysine; D008565:Membrane Proteins; D009687:Nuclear Proteins; D016601:RNA-Binding Proteins; C093206:fructosyllysine-binding protein, human; C033186:fructosyl-lysine