Blood clotting activation during normal pregnancy.
Pregnancy is considered as a hypercoagulable state and an increased incidence of thromboembolic phenomena has been reported in pregnant women. Relevant changes in the hemostatic mechanism have been reported during physiological pregnancy: briefly, increased levels of coagulation factors, enhanced thrombin generation and suppression of fibrinolysis are commonly found in women with uncomplicated pregnancy. We recently described progressive increases in fibrinogen and D-dimer plasma levels during normal pregnancy. The increase in D-dimer levels makes difficult their interpretation for the exclusion of thromboembolic phenomena in pregnancy. The behavior of prothrombin fragment 1+2 (F1+2) levels during physiological pregnancy is scarcely known. The aim of this preliminary study was to establish range values of F1+2 plasma levels for different periods of normal pregnancy.
Comeglio
P
P
Istituto di Clinica Medica Generale e Cardiologia, University of Florence, Italy.
Fedi
S
S
Liotta
A A
AA
Cellai
A P
AP
Chiarantini
E
E
Prisco
D
D
Mecacci
F
F
Parretti
E
E
Mello
G
G
Abbate
R
R
D000328:Adult; D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D011516:Prothrombin / Q000032:analysis*
D011516:Prothrombin; D005340:Fibrinogen