Clonal identification of Burkitt's lymphoma arising from lymphocyte-predominant Hodgkin's disease.
The occurrence of large cell lymphomas subsequent to, or concurrent with, lymphocyte predominant Hodgkin's disease (LPHD) is a well-documented phenomenon. We present a case of Burkitt's lymphoma of the bladder, occurring after the successful treatment of LPHD of a cervical lymph node. To evaluate the clonal relationship of the two tumours, we amplified the complementarity-determining-region 3 of two samples from paraffin-embedded slides, using the polymerase chain reaction (PCR). The sequences of the PCR products showed 96% homology to each other. These results indicate that the malignant clone of Burkitt's lymphoma arose from the corresponding LPHD.
First Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
H
H
Yoshinaga
K
K
Ohashi
K
K
Yamamoto
T
T
Miki
O
O
Miura
T
T
Saito
T
T
Koyama
A
A
Kanazawa
T
T
Nemoto
N
N
Miyasaka
R
R
Kamiyama
S
S
Hirosawa
D000368:Aged; D002051:Burkitt Lymphoma / Q000235:genetics*; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D006689:Hodgkin Disease / Q000188:drug therapy / Q000235:genetics*; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D012689:Sequence Homology, Nucleic Acid; D001749:Urinary Bladder Neoplasms / Q000235:genetics*