Alterations in phagocyte function and periodontal infection.
A review of phagocytic cells-polymorphonuclear leukocytes and monocytes-in the inflammatory process is presented. Examples of phagocyte defect-related pathology serve as a framework for understanding the role of these cells in periodontal infection. The role of alterations in neutrophil function in localized juvenile periodontitis is presented as a model system for understanding periodontal pathology as a result of host-related functional abnormalities. Two topical alternative hypotheses for periodontal breakdown are presented in which macrophage control of the chronic lesion is altered by an absence of T cells or the influence of bacterial superantigens.
Daniel
M A
MA
Department of Periodoniotogy and Oral Biology, Boston University, MA, USA.
Van Dyke
T E
TE
D010520:Aggressive Periodontitis / Q000276:immunology / Q000382:microbiology; D000942:Antigens, Bacterial / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000502:physiology; D009000:Monocytes / Q000276:immunology / Q000502:physiology; D009504:Neutrophils / Q000276:immunology / Q000502:physiology; D010510:Periodontal Diseases / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D010586:Phagocytes / Q000276:immunology / Q000502:physiology*; D018089:Superantigens / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology
D000942:Antigens, Bacterial; D018089:Superantigens