Effect of six-month treatment with Ukrain on early osteoporosis induced by ovariectomy in rats. Part III. Preliminary studies of some hormone levels.
The effect of six-month treatment with Ukrain on the level of some hormones was investigated in ovariectomized rats. The serum levels of prolactin, adrenocorticotropic hormone (ACTH), corticosterone, aldosterone and progesterone were measured by radioimmunoassay (RIA). Six months after ovariectomy, a decrease in prolactin and progesterone levels was observed. No changes were noted in the levels of ACTH, corticosterone and aldosterone in the serum of the ovariectomized animals. On the other hand, six-month treatment with Ukrain increased the levels of prolactin and progesterone and decreased the levels of corticosterone and aldosterone in the ovariectomized rats. The progesterone level in the treated group was four times higher than in the ovariectomized group. The six-month treatment with Ukrain had no effect on the level of ACTH of the serum of the ovariectomized rats. The present results show that prolonged treatment with Ukrain significantly affects hormone secretion after ovariectomy.
Department of Pharmacology, Medical Academy, Lublin, Poland.
E
E
Jagiełło-Wojtowicz
Z
Z
Kleinrok
J W
JW
Nowicky
E
E
Baran
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000450:Aldosterone / Q000097:blood; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001600:Berberine Alkaloids; D003345:Corticosterone / Q000097:blood; D004334:Drug Administration Schedule; D005260:Female; D006728:Hormones / Q000097:blood*; D010024:Osteoporosis / Q000097:blood* / Q000188:drug therapy* / Q000209:etiology; D010052:Ovariectomy / Q000009:adverse effects; D010617:Phenanthridines; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar
D000470:Alkaloids; D001600:Berberine Alkaloids; D006728:Hormones; D010617:Phenanthridines; D000450:Aldosterone; D011374:Progesterone; C060921:ukrain; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D003345:Corticosterone