Laparoscopic lymph node assessment in pretherapeutic staging of gastric and esophageal cancer.
In gastric cancer lymph node metastases at the hepatoduodenal ligament and in esophageal cancer, metastases at the celiac axis are classified as distant metastases (M1 LYMPH) and implying a poor prognosis. In pretherapeutic staging, imaging procedures such as computed tomography of the abdomen or transcutaneous ultrasonic examination are of limited value in the assessment of enlarged or metastatic lymph nodes. Conversely, laparoscopic staging with subsequent biopsy of suspicious lymph nodes provides essential diagnostic information. After exclusion of distant metastases (liver, lung, bone) in 73 patients with esophageal-(n = 21) and gastric cancer (n = 52), staging laparoscopy, including laparoscopic ultrasound, were performed during an 18-month-period (July/ 93-December/94). After laparoscopic exclusion of peritoneal seedings, the hepatoduodenal ligament was examined and enlarged lymph nodes were biopsied. In a total of 73 patients, laparoscopy revealed previously undiagnosed liver metastases in 14 and peritoneal carcinosis in 19 patients. Additionally, in eight (esophageal cancer; n = 3, gastric cancer; n = 5) of the remaining 40 patients, lymph nodes in the M1-position were regarded suspicious and biopsied. In six of these, malignant spread was observed. Thus, in a further six of 40 patients, surgically incurable situations could be detected. In esophageal and gastric cancer, staging laparoscopy, including laparoscopic ultrasound and biopsy, is a sensitive technique to assess local tumor spread and distant metastases. The detection of M1- lymph node metastases is facilitated by the use of laparoscopic ultrasound. Tumor spread, which limits surgical curability, can be properly assessed and exploratory laparotomy avoided.
Virchow Klinikum, Medical Faculty of the Humboldt University, Robert-Rössle Cancer Hospital, Max Delbrück Center of Molecular Medicine, Berlin, Germany.
B
B
Rau
M
M
Hünerbein
B
B
Reingruber
P
P
Hohenberger
P M
PM
Schlag
D004938:Esophageal Neoplasms / Q000473:pathology* / Q000628:therapy; D006801:Humans; D010535:Laparoscopy; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000473:pathology* / Q000628:therapy