Prostate-specific antigen concentrations in serum in acute illnesses.
In light of recent studies showing that prostate-specific antigen (PSA) complexes with certain blood proteins, we studied the effects of acute-phase reactants and alpha 2-macroglobulin (A2MG) on serum concentrations of PSA. Serum samples were obtained from 419 men admitted to an acute-care facility. Various acute-phase reactants-including C-reactive protein, alpha 1-acid glycoprotein, alpha 1-antitrypsin, and alpha 1-antichymotrypsin-and A2MG were measured with a Beckman Array analyzer in parallel with determinations of PSA concentrations by two methods, the Hybritech Tandem RIA and the Abbott PSA IMx. Evaluation by Spearman rank correlation revealed a significant negative correlation of A2MG with PSA values (P < 0.01) and (as expected) a positive correlation of age with PSA values (P < 0.001). The former correlation suggests the possibility that patients with high serum concentrations of A2MG may give falsely decreased results for PSA concentrations in serum.
Kaiser foundation Hospital, Honolulu, HI, USA.
S A
SA
Honda
A P
AP
Goldstein
T
T
Morita
C
C
Sugiyama
L
L
Cody
C N
CN
Rios
N V
NV
Bhagavan
D000208:Acute Disease; D000209:Acute-Phase Proteins / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000375:Aging; D001798:Blood Proteins / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D009961:Orosomucoid / Q000378:metabolism; D017430:Prostate-Specific Antigen / Q000097:blood*; D011863:Radioimmunoassay; D000514:alpha 1-Antichymotrypsin / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism*
D000209:Acute-Phase Proteins; D001798:Blood Proteins; D009961:Orosomucoid; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D002097:C-Reactive Protein; D017430:Prostate-Specific Antigen