Pathogenesis of primary hepatocellular carcinoma.
Primary hepatocellular carcinoma (HCC) is a major cause of mortality world-wide, with a poorly understood pathogenesis. We review known aetiological factors and the mechanisms whereby they are associated with the development of hepatocellular carcinoma. The increasing knowledge of the dysregulation of cellular growth control that occurs during HCC development is discussed in detail.
Gastrointestinal Centre, Southern General Hospital, Glasgow, UK.
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GW
Curry
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AD
Beattie
D000348:Aflatoxins / Q000009:adverse effects; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D002471:Cell Transformation, Neoplastic; D002908:Chronic Disease; D004700:Endocrine System Diseases / Q000150:complications; D004967:Estrogens / Q000502:physiology; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006509:Hepatitis B / Q000150:complications; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications; D008113:Liver Neoplasms / Q000209:etiology / Q000473:pathology / Q000503:physiopathology
D000348:Aflatoxins; D004967:Estrogens; D012739:Gonadal Steroid Hormones