Developing new synthetic catalysts. How nature does it.
Paleomolecular biochemistry is a new field of science that seeks to understand how life emerged and developed in interaction with its geophysical surroundings. It is an experimental science, involving reconstruction of extinct biomolecules in the laboratory, studying their properties in the laboratory, and inferring details of their behavior and function in the context of geological data. An outline is provided of some tools of this field, together with its application to the study of two specific systems, ribonuclease and alcohol dehydrogenase.
Benner
S A
SA
Department of Chemistry, ETH, Zürich, Switzerland.
Jermann
T M
TM
Opitz
J G
JG
Raillard
S A
SA
Zankel
T R
TR
Trautwein-Fritz
K
K
Stackhouse
J
J
Ciglic
M I
MI
Haugg
M
M
Trabesinger-Rüf
N
N
Weinhold
E G
EG
D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D002384:Catalysis; D004798:Enzymes / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data
D004798:Enzymes