Tumor necrosis factor-alpha and interleukin-1 beta. Two possible mediators of allergic inflammation.
Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin 1-beta (IL-1 beta) and interleukin-2-(IL-2) were measured in 19 atopic subjects and in 8 healthy controls. TNF-alpha concentration was increased in atopic subjects and the increase was correlated with the severity of the disease in patients affected by atopic dermatitis. Increased plasma levels of IL-1 beta were found only in symptomatic asthmatic subjects. No increase of serum IL-2 concentration was found in atopic subjects. The data suggest a possible role of TNF- alpha and IL-1 beta in the pathophysiological mechanism of the allergic inflammation.
Division of Pediatrics, General Hospital IRCCS, Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Foggia.
M
M
Pellegrino
B
B
Minervini
P
P
Musto
R
R
Matera
A
A
Greco
C
C
Checchia de Ambrosio
D001249:Asthma / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000276:immunology*; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007124:Immunoenzyme Techniques; D007223:Infant; D007249:Inflammation / Q000276:immunology*; D007375:Interleukin-1 / Q000276:immunology; D007376:Interleukin-2 / Q000276:immunology; D008297:Male; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
D007375:Interleukin-1; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha