An extended 10-day course of clomiphene citrate (CC) in women with CC-resistant ovulatory disorders.
OBJECTIVE
To evaluate the effectiveness of extended duration clomiphene citrate (CC) (100 mg for 10 days) as an alternative to complex ovulation induction strategies for women who fail to ovulate despite standard incremental doses of CC of > or = 150 mg for 5 days.


METHODS
Retrospective case series.


METHODS
University-based infertility practice.


METHODS
Thirty women with CC-resistant World Health Organization group II ovulatory disorders.


METHODS
At least one cycle of 100 mg CC from days 3 to 12.


RESULTS
Fourteen patients (47%) ovulated during 31 of their 48 cycles (65%). Five women (17%) conceived a total of seven singleton pregnancies, including five term deliveries and two spontaneous abortions. Weight, body mass index, and the presence of hyperandrogenism did not predict responsiveness to the extended duration CC. Side effects were similar to those reported during standard CC treatment.


CONCLUSIONS
An extended 10-day course of CC provides a simple, noninvasive, and inexpensive alternative for a subset of women with ovulatory disorders that are refractory to standard CC treatment.
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada.
M R
MR
Fluker
I Y
IY
Wang
T C
TC
Rowe
D000328:Adult; D000858:Anovulation / Q000188:drug therapy*; D002996:Clomiphene / Q000008:administration & dosage* / Q000627:therapeutic use; D004351:Drug Resistance; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage* / Q000627:therapeutic use; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D007986:Luteinizing Hormone / Q000097:blood; D010062:Ovulation Induction; D011247:Pregnancy; D012189:Retrospective Studies; D013739:Testosterone / Q000097:blood
D005300:Fertility Agents, Female; D002996:Clomiphene; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone