Tumor necrosis factor beta gene polymorphism and early primary kidney allograft loss.
The purpose of this study was to examine the association of TNFB alleles and genotypes in recipients experiencing early cadaveric kidney graft loss and non-early graft loss. Because the TNFB1 allele is associated with increased production of the TNF beta lymphotoxin following PHA mitogenic stimulation in vitro, the frequency of this allele was examined in renal transplant recipients experiencing early graft loss. A similar expression of TNFB alleles and genotypes was found in the early regraft loss group (< or = 3 months; n = 16) and non-early graft loss group (n = 81). We conclude that alleles of the TNFB gene are not risk factors for early cadaveric kidney graft loss.
Mahoney
R J
RJ
Immunogenetics Laboratory, Maine Medical Center Research Institute, South Portland 04106, USA.
Szatkowski
M A
MA
White
B A
BA
Leeber
D A
DA
D005260:Female; D006084:Graft Rejection / Q000145:classification* / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D008233:Lymphotoxin-alpha / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D014184:Transplantation, Homologous / Q000276:immunology*
D008233:Lymphotoxin-alpha