Induction of Fos protein expression in spinal cord neurons by herpes simplex virus infections in the mouse.
After the inoculation of a highly attenuated strain of herpes simplex virus (HSV) type 1 into the mouse hind-paw planter skin, a few neurons and glial cells were viral antigen-positive in the dorsal root ganglia (DRGs) and anterior horn of L4 and L5 segments of the lumbar spinal cord. Fos-containing nuclei, however, were not found in the DRGs or the lumbar cord segments. After the inoculation of a highly neuroinvasive strain of HSV type 2, many virus-positive neurons and glial cells were detected in the DRGs, anterior and posterior horns at L4 and L5; Fos-containing nuclei were also observed in spinal neurons except for motoneurons. The results indicate that transneuronal infection of HSV induces Fos expression in spinal neurons.
Ozaki
N
N
Department of Anatomy, Fukushima Medical College, Japan.
Sugiura
Y
Y
Yamamoto
M
M
Nishiyama
Y
Y
D000818:Animals; D002522:Chlorocebus aethiops; D015967:Gene Expression Regulation, Viral; D006561:Herpes Simplex / Q000378:metabolism* / Q000821:virology; D018259:Herpesvirus 1, Human; D018258:Herpesvirus 2, Human; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009457:Neuroglia / Q000821:virology; D009474:Neurons / Q000378:metabolism* / Q000821:virology; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism* / Q000821:virology; D014709:Vero Cells
D016760:Proto-Oncogene Proteins c-fos