The effect of aprotinin on thrombelastography in vitro.
The effect of low dose (50 KIU/ml) and high dose (200 KIU/ml) aprotinin on standard thrombelastographic variables (r, K, alpha, MA) was examined in vitro using blood from forty ASA Class 1 patients. Both concentrations of aprotinin resulted in minor increases in r time above the normal range (P < 0.05). Aprotinin did not alter other thrombelastographic variables. The results indicate that aprotinin is a mild direct anticoagulant in vitro as assessed by thrombelastography.
Department of Anaesthesia, Sir Charles Gairdner Hospital Nedlands, W.A.
G A
GA
Chalkiadis
N M
NM
Gibbs
D000293:Adolescent; D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000494:pharmacology; D007611:Aprotinin / Q000008:administration & dosage / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006490:Hemostatics / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013916:Thrombelastography / Q000187:drug effects*
D000925:Anticoagulants; D006490:Hemostatics; D007611:Aprotinin