Diagnosis, treatment, and temporary remission of disseminated paecilomycosis in a vizsla.
A case of disseminated paecilomycosis in a three-year-old vizsla is described. Clinical signs of lethargy, weight loss, lymphadenopathy, diarrhea, and vestibulocochlear deficits were exhibited. Dense colonization of bone marrow by the fungus was found early in the disease course. Serial culture of bone-marrow aspirates and in vitro sensitivity testing helped monitor disease progression and guide antifungal therapy. Clinical and laboratory parameters demonstrated marked improvement for a period of 12 weeks. Multisystemic disease with central nervous system involvement was found at necropsy.
Department of Medicine, School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts 01536, USA.
P A
PA
March
K
K
Knowles
C L
CL
Dillavou
R
R
Jakowski
G
G
Freden
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D001853:Bone Marrow / Q000187:drug effects / Q000382:microbiology / Q000473:pathology; D018450:Disease Progression; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D005260:Female; D008264:Macrophages / Q000473:pathology; D009181:Mycoses / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D010143:Paecilomyces / Q000302:isolation & purification*; D012680:Sensitivity and Specificity
D000935:Antifungal Agents