Salivary peroxidase activity in whole saliva of patients with insulin-dependent (type-1) diabetes mellitus.
In this study, salivary peroxidase activity was measured in a group of 10 patients with insulin-dependent (type I) diabetes mellitus (IDDM) who had a tendency towards periodontitis. In healthy subjects (N : 10), mean salivary peroxidase activity was 0.0025 +/- 0.001 IU/ml, while in this group of type I diabetic patients it was 0.051 +/- 0.015 IU/ml, a significantly higher level (p < 0.001). Approximal plaque index (API), modified sulcus bleeding index (mod SBI) and pocket depths were assessed clinically. The values for mod SBI and API were 60% and 68% respectively for the diabetic patients while for the control group mod SBI was measured 0.0% and the value for API was 10.67% (p < 0.001). The administration of this simple and practical test may provide an early marker of a tendency towards periodontitis in IDDM patients.
Department of Biochemistry, Faculty of Dentistry, University of Istanbul, Capa, Turkey.
Y
Y
Güven
I
I
Satman
N
N
Dinççağ
S
S
Alptekin
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000032:analysis; D003774:Dental Plaque Index; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D005884:Gingival Hemorrhage / Q000473:pathology; D006801:Humans; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000473:pathology; D010518:Periodontitis / Q000201:enzymology; D010544:Peroxidases / Q000032:analysis*; D012463:Saliva / Q000201:enzymology*; D012471:Salivary Proteins and Peptides / Q000032:analysis; D013053:Spectrophotometry
D015415:Biomarkers; D012471:Salivary Proteins and Peptides; D010544:Peroxidases