Comparison of the protective response induced by NYVAC vaccinia recombinants expressing either gp50 or gII and gp50 of pseudorabies virus.
A NYVAC vaccinia vector containing genes for pseudorables virus glycoproteins gII and gp50 was administered to pigs to determine if it would have a greater protective effect than a vector containing the gene for gp50 alone. Both NYVAC vectors protected pigs similarly from virulent pseudorabies virus challenge.
Virology Swine Research Unit, USDA, Ames, Iowa 50010, USA.
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Brockmeier
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Mengeling
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology / Q000378:metabolism*; D001831:Body Temperature / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D005822:Genetic Vectors; D011558:Herpesvirus 1, Suid / Q000276:immunology* / Q000378:metabolism; D008297:Male; D011557:Pseudorabies / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control*; D013552:Swine / Q000276:immunology* / Q000378:metabolism / Q000502:physiology; D013553:Swine Diseases / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control*; D014614:Vaccines, Synthetic / Q000235:genetics* / Q000276:immunology / Q000494:pharmacology*; D014760:Viral Fusion Proteins / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism
D000914:Antibodies, Viral; D014614:Vaccines, Synthetic; D014760:Viral Fusion Proteins