Correlated biochemical modifications of plasma lipoproteins in coronary heart disease: an accelerating pathologic factor.
We investigated the presence of biochemically modified plasma lipoproteins as pathologic factor for coronary heart disease in 15 patients with angina pectoris (CHD-P) vs 20 normal subjects (N). Decreased HDL were the most significant pathological feature present in P over 66 years old, while, P under 66 had, in addition to low HDL-Cholesterol (HDL-C), high levels of plasma cholesterol (C), LDL-Cholesterol (LDL-C), and lipid peroxides (TBARS), together with the presence of desialylated LDL and VLDL. We demonstrated by statistic analysis that these risk factors are correlated: high plasma C with a more pronounced imbalance between LDL and HDL, which, in turn, is associated with high TBARS levels, and also with circulating desialylated VLDL; high plasma TBARS values with desialylated LDL. We detected an increased level of autoantibodies towards autologous LDL and VLDL, in P vs N. The level of autoantibodies anti-LDL correlated with LDL-C level and with LDL desialylation, thus modified circulating LDL being most probably atherogenic. Circulating anti-LDL autoantibodies together with the low level of HDL might contribute to acceleration and aggravation of the atherosclerotic process.
Nicolae Simionescu Institute of Cellular Biology and Pathology, Bucharest, Romania.
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A
Sima
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I
Hobai
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C
Stancu
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Cinteză
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L
Gherasim
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000097:blood; D001323:Autoantibodies / Q000097:blood; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000097:blood*; D005215:Fasting / Q000097:blood; D006801:Humans; D016014:Linear Models; D008074:Lipoproteins / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D001323:Autoantibodies; D008074:Lipoproteins; D002784:Cholesterol