Graft-versus-host effect after allogeneic hematopoietic stem cell transplantation: GVHD and GVL.
The development of a graft-versus-host reaction after allogeneic hematopoietic stem cell transplantation is an important determinant of the transplant outcome. A better understanding and improved management of the graft-versus-host reaction should allow improved prevention and treatment of graft-versus-host disease and the development of new strategies to enhance a graft-versus-leukemia effect and to decrease the incidence of leukemic relapse after transplantation.
Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA. rnash@fhcrc.org
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D000818:Animals; D015815:Cell Adhesion Molecules / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D004195:Disease Models, Animal; D006086:Graft vs Host Disease / Q000209:etiology / Q000276:immunology* / Q000517:prevention & control; D006087:Graft vs Host Reaction; D006680:HLA Antigens / Q000235:genetics; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D007125:Immunogenetics; D007938:Leukemia / Q000276:immunology / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous
D015815:Cell Adhesion Molecules; D016207:Cytokines; D006680:HLA Antigens