Port-access mitral valve replacement in dogs.
OBJECTIVE
The objective was to assess mitral valve replacement in a minimally invasive fashion by means of port-access technology.


METHODS
Fifteen dogs, 28 +/- 3 kg (mean +/- standard deviation), were studied with the port-access mitral valve replacement system (Heartport, Inc., Redwood City, Calif.). Eleven dogs underwent acute studies and were sacrificed immediately after the procedure. Four dogs were allowed to recover and then were sacrificed 4 weeks after operation. Cardiopulmonary bypass was conducted by femoral cannulation with an endovascular balloon catheter for aortic occlusion, root venting, and antegrade delivery of cardioplegic solution. Catheters were inserted in the jugular vein for pulmonary artery venting and retrograde delivery of cardioplegic solution. Through the oval port, a prosthesis (St. Jude Medical, Inc., St. Paul, Minn., or CarboMedics, Inc., Austin, Texas) was inserted through the left atrial appendage and secured to the anulus with sutures. Deairing was performed.


RESULTS
Cardiopulmonary bypass duration was 114 +/- 24 minutes and aortic crossclamp time was 68 +/- 14 minutes. All animals were weaned from cardiopulmonary bypass in sinus rhythm. Cardiac output and pulmonary artery occlusion pressure were unchanged (2.8 +/- 0.7 L/min and 7 +/- 3 mm Hg before operation vs 2.6 +/- 0.6 L/min and 9 +/- 4 mm Hg after operation). There was no mitral regurgitation according to left ventriculography in 13 of 15 dogs. In two dogs there was interference with prosthetic valve closure by residual native anterior leaflet tissue. Pathologic examination otherwise showed normal healing without perivalvular discontinuity. Microscopic studies showed no damage to the valve surfaces. Transthoracic echocardiography of the four dogs in the long-term study showed normal ventricular and prosthetic valve function 4 weeks after the operation.


CONCLUSIONS
Mitral valve replacement with a minimally invasive method has been demonstrated in dogs. A clinical trial is in progress.
Department of Cardiothoracic Surgery, Stanford University School of Medicine, Calif., USA.
M F
MF
Pompili
J H
JH
Stevens
T A
TA
Burdon
L C
LC
Siegel
W S
WS
Peters
G H
GH
Ribakove
B A
BA
Reitz
D000818:Animals; D002315:Cardiopulmonary Bypass; D004195:Disease Models, Animal; D004285:Dogs; D004724:Endoscopy; D005240:Feasibility Studies; D019060:Minimally Invasive Surgical Procedures; D008943:Mitral Valve / Q000601:surgery*; D014741:Video Recording