HLA-identical sibling bone marrow transplants vs chemotherapy for acute myelogenous leukemia in first remission.
There is controversy whether adults with acute myelogenous leukemia (AML) in first remission are best treated with chemotherapy or an HLA-identical sibling bone marrow transplant. We studied 1097 adults, 16-50 years old, with AML in first remission. Results of transplants from HLA-identical siblings reported to the International Bone Marrow Transplant Registry (IBMTR; n = 901) were compared with results of chemotherapy in comparable persons treated by the German AML Cooperative Group (GAMLCG; n = 196). Preliminary analyses identified subject- and disease-related variables differing between the cohorts and associated with treatment outcome within each cohort. We adjusted for these variables and differences in time-to-treatment in subsequent comparisons of treatment-related mortality, relapse, survival and leukemia-free survival (LFS). Five-year probability of treatment-related mortality was greater for transplants than chemotherapy (43% (95% confidence interval, 37-49%) vs 7% (3-11%); P< 0.0001). Five-year relapse probability was less for transplants than chemotherapy (24% (20-28%) vs 63% (55-71%); P< 0.0001). Five-year probability of survival was similar with transplants and chemotherapy (48% (43-53%) vs 42% (33-51%); P = 0.24). Five-year LFS probability was higher for transplants than chemotherapy (46% (42-50%) vs 35% (28-41%); P= 0.01). These data indicate that bone marrow transplants from HLA-identical siblings result in comparable survival but greater LFS than chemotherapy in adults with AML in first remission.
Division of Bone Marrow and Stem Cell Transplantation, Salick Health Care, Los Angeles, CA, USA.
R P
RP
Gale
T
T
Büchner
M J
MJ
Zhang
A
A
Heinecke
R E
RE
Champlin
K A
KA
Dicke
E
E
Gluckman
R A
RA
Good
A
A
Gratwohl
R H
RH
Herzig
A
A
Keating
J P
JP
Klein
A M
AM
Marmont
H G
HG
Prentice
P A
PA
Rowlings
K A
KA
Sobocinski
B
B
Speck
R S
RS
Weiner
M M
MM
Horowitz
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000276:immunology*; D015331:Cohort Studies; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000276:immunology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009679:Nuclear Family; D016896:Treatment Outcome
D006680:HLA Antigens