Metabolic effects of dietary sucrose and fructose in type II diabetic subjects.
OBJECTIVE
To investigate the metabolic effects of dietary fructose and sucrose in type II diabetic patients.


METHODS
Sixteen well-controlled type II diabetic subjects were fed three isocaloric diets for 28 days each. The three diets provided 50-55, 15, and 30-35% of total energy from carbohydrate, protein, and fat, respectively. In one diet, 20% of total calories were derived from fructose; in another, 19% of total calories were derived from sucrose; and in the control diet, only 5% of daily calories were derived from sugars, all other carbohydrates being supplied as polysaccharides.


RESULTS
No significant differences were observed between either the fructose or the sucrose diet and the control polysaccharide diet in any of the measures of glycemic control, serum lipid levels, or insulin and C-peptide secretion.


CONCLUSIONS
Our data suggest that in the short and middle terms, high fructose and sucrose diets do not adversely affect glycemia, lipemia, or insulin and C-peptide secretion in well-controlled type II diabetic subjects.
Endocrine and Nutrition Services, Hospital das Clínicas, University of Säo Paulo Medical School, Brazil.
D A
DA
Malerbi
E S
ES
Paiva
A L
AL
Duarte
B L
BL
Wajchenberg
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D001798:Blood Proteins / Q000032:analysis; D001835:Body Weight; D002096:C-Peptide / Q000097:blood; D002747:Chlorpropamide / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000178:diet therapy / Q000188:drug therapy; D004040:Dietary Carbohydrates; D019422:Dietary Sucrose; D002149:Energy Intake; D005260:Female; D005632:Fructose; D005905:Glyburide / Q000627:therapeutic use; D006023:Glycoproteins; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D014280:Triglycerides / Q000097:blood; D000093422:Glycated Serum Proteins
D001786:Blood Glucose; D001798:Blood Proteins; D002096:C-Peptide; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004040:Dietary Carbohydrates; D019422:Dietary Sucrose; D006023:Glycoproteins; D007004:Hypoglycemic Agents; D007328:Insulin; D014280:Triglycerides; D005632:Fructose; D002784:Cholesterol; D005905:Glyburide; D002747:Chlorpropamide; D000093422:Glycated Serum Proteins