Vitamin K status influences brain sulfatide metabolism in young mice and rats.
The established role of vitamin K in nutrition is as a cofactor in the post-translational conversion of specific glutamyl to gamma-carboxyglutamyl (Gla) residues in a limited number of proteins. Administration of the vitamin K antagonist warfarin has previously been shown to decrease brain sulfatide concentrations and decrease brain galactocerebroside sulfotransferase (GST) activity in young mice. A dietary deficiency of vitamin K has now been shown to decrease (P < 0.01) brain sulfatide concentrations of 30-d-old mice significantly (by 21%). Male 21-d-old rats fed an excess of vitamin K for 7 or 14 d had 26 and 31% (P < 0.05) greater GST activity and 15 and 18% (P < 0.05) greater brain sulfatide concentrations, respectively, than controls fed a vitamin K-deficient diet. Male 21-d-old rats fed a diet containing 500 mg of phylloquinone/kg diet had an intermediate response and were vitamin K sufficient by normal criteria. The vitamin K response was observed when either phylloquinone or menaquinone-4 was fed as a source of the vitamin. These data suggest that in addition to its recognized role in Gla synthesis, vitamin K status is important in the maintenance of normal complex lipid sulfatide metabolism in young rats and mice.
Sundaram
K S
KS
Department of Microbiology and Immunology, CUNY Medical School, City College, New York, NY 10031, USA.
Fan
J H
JH
Engelke
J A
JA
Foley
A L
AL
Suttie
J W
JW
Lev
M
M
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D001923:Brain Chemistry; D005527:Food, Fortified; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D051381:Rats; D017207:Rats, Sprague-Dawley; D013433:Sulfoglycosphingolipids / Q000032:analysis / Q000378:metabolism*; D015238:Sulfotransferases / Q000032:analysis / Q000378:metabolism; D014812:Vitamin K / Q000097:blood* / Q000494:pharmacology / Q000502:physiology*; D010837:Vitamin K 1 / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology; D014859:Warfarin / Q000494:pharmacology
D013433:Sulfoglycosphingolipids; D014812:Vitamin K; D014859:Warfarin; D010837:Vitamin K 1; D015238:Sulfotransferases; C020556:galactosylceramide sulfotransferase