Peripheral beta-adrenoreceptors and stress-induced hypercholesterolemia in rats.
Three experiments were conducted examining the contribution of beta-adrenergic receptors to stress-induced cholesterol increases. Rats were exposed to 3 90-min sessions of inescapable tailshock, or left undisturbed in their home cage. Propranolol, a nonselective beta-blocker, attenuated the stress-induced cholesterol increase when administered prior to the daily shock session. Atenolol, a beta-1 specific antagonist, also attenuated the stress-induced cholesterol increase. Butoxamine, a beta-2 specific antagonist, had no effect on the stress-induced cholesterol increases. Results are discussed in terms of catecholamine-stimulated free fatty acid (FFA) release as a potential mechanism for producing stress-induced hypercholesterolemia.
Brennan
F X
FX
Psychology Department, University of Colorado, Boulder 80309, USA. brennaf@wilkes1.wilkes.edu
Cobb
C L
CL
Silbert
L H
LH
Watkins
L R
LR
Maier
S F
SF
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001262:Atenolol / Q000494:pharmacology; D002078:Butoxamine / Q000494:pharmacology; D004597:Electroshock; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006937:Hypercholesterolemia / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D018342:Receptors, Adrenergic, beta-1 / Q000187:drug effects / Q000502:physiology; D018343:Receptors, Adrenergic, beta-2 / Q000187:drug effects / Q000502:physiology; D013315:Stress, Psychological / Q000150:complications / Q000503:physiopathology*
D000319:Adrenergic beta-Antagonists; D005230:Fatty Acids, Nonesterified; D011943:Receptors, Adrenergic, beta; D018342:Receptors, Adrenergic, beta-1; D018343:Receptors, Adrenergic, beta-2; D002078:Butoxamine; D001262:Atenolol; D011433:Propranolol