Hormonal regulation of serum and endometrial IL-1 alpha, IL-1 beta and IL-1ra: IL-1 endometrial microenvironment of the human embryo at the apposition phase under physiological and supraphysiological steroid level conditions.
We have investigated serum and intracavitary levels of IL-1 alpha, IL-1 beta and IL-1ra from agonadal women undergoing mock cycles (n = 20) of oocyte donation as a clinical model of controlled hormonal stimulation. Further, we compared the intracavitary IL-1 alpha, IL-1 beta and IL-1ra levels in the microenvironment of the human embryo at the apposition phase, day 5 after progesterone (P) administration using two different clinical models: oocyte donation (n = 20) which provides physiological steroid levels and a higher implantation rate per embryo, and in vitro fertilization (n = 6) with supraphysiological hormonal levels and a lower implantation rate.
Simón
C
C
Instituto Valenciano de Infertilidad, Valencia University, Spain.
Mercader
A
A
Frances
A
A
Gimeno
M J
MJ
Polan
M L
ML
Remohí
J
J
Pellicer
A
A
D005314:Embryonic and Fetal Development / Q000276:immunology*; D004717:Endometrium / Q000098:blood supply / Q000276:immunology* / Q000378:metabolism; D005260:Female; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000097:blood*; D008833:Microcirculation; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000502:physiology; D011374:Progesterone / Q000032:analysis* / Q000494:pharmacology*; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors* / Q000187:drug effects; D012795:Sialoglycoproteins / Q000096:biosynthesis* / Q000097:blood* / Q000187:drug effects
C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins; D011374:Progesterone