A linkage study of schizophrenia with DNA markers from chromosome 8p21-p22 in 25 multiplex families.
Two recent genome-wide searches for linkage (Lasseter et al., 1994; Moises et al., 1995) suggested that a susceptibility gene for schizophrenia might be located at chromosome 8p21-p22. We attempted to replicate these findings by performing a linkage study of schizophrenia with four DNA markers from this region using 25 multiply affected families. Neither the lod score method nor non-prametric extended sib-pair analysis yielded any evidence for linkage, even under the assumption of locus heterogeneity. We conclude that there is unlikely to be a major gene in the 8p21-p22 region which confers susceptibility to schizophrenia in our set of families. However we cannot exclude the possibility of a major gene present in other families, or of a susceptibility gene with a moderate but widespread effect which we cannot detect.
Department of Psychological Medicine, Institute of Psychiatry, London, UK.
H
H
Kunugi
D
D
Curtis
H P
HP
Vallada
S
S
Nanko
J F
JF
Powell
R M
RM
Murray
P
P
McGuffin
M J
MJ
Owen
M
M
Gill
D A
DA
Collier
D001345:Autoradiography; D002892:Chromosomes, Human, Pair 22; D002898:Chromosomes, Human, Pair 8; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D010375:Pedigree; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000235:genetics*