The captopril test in children with renovascular and renal hypertension.
We used the captopril test (CT) in 32 children, 8 with renovascular hypertension (RVH), 17 with renal hypertension (RH) and 7 with normal blood pressure, in order to study the renin-angiotensin system activation (RASA). All children affected by RVH presented a positive CT: a post-captopril plasma renin activity (PRA) of 12 ng ml-1 h-1 or more, an absolute PRA increase of 10 ng ml-1 h-1 or more and a 150% increase or more, or 400% or more if the baseline PRA was less than 3 ng ml-1 h-1. The CT may be useful for demonstrating the RASA in RVH.
Fossali
E
E
Clinica pediatrica II, Università di Milano, Italy.
Intermite
R
R
Minoja
M
M
Tirelli
S
S
Sereni
F
F
D000293:Adolescent; D000806:Angiotensin-Converting Enzyme Inhibitors; D001794:Blood Pressure; D002216:Captopril; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006977:Hypertension, Renal / Q000175:diagnosis* / Q000503:physiopathology; D007223:Infant; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System
D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril; D012083:Renin