Standardized assessment to enhance the diagnostic value of prostate volume; Part II: Correlation with prostate-specific antigen levels.
BACKGROUND
Standardized estimations of prostate volumes are used for interpretation of prostate specific antigen (PSA) levels.


METHODS
In 243 patients with clinically benign diagnosis, automated and reference prostate volumes and transition zone volumes are correlated to PSA levels. Besides, growth curves of PSA level when aging are determined.


RESULTS
The strongest correlation was found with multiple regression analysis between PSA and transition zone volume and rest volume (R = 0.854). Mean PSA density was 0.092 ng/mL2, its labelling quality for benign disease was 91% (threshold = 0.15 ng/mL2). An average growth factor for PSA levels of 2.9% per year was obtained.


CONCLUSIONS
The contribution per unit tissue to PSA level was for the transition zone 1.9 times higher than for the rest volume. Average growth of PSA per year is in consonance with the increase in normal levels of age specific PSA ranges, although only weak correlations were found between PSA and age and PSA density and age.
Department of Urology, Biomedical Engineering Unit, Nijmegen, The Netherlands.
R G
RG
Aarnink
J J
JJ
de la Rosette
A L
AL
Huynen
R J
RJ
Giesen
F M
FM
Debruyne
H
H
Wijkstra
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011469:Prostatic Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D012016:Reference Values; D012044:Regression Analysis; D014463:Ultrasonography
D017430:Prostate-Specific Antigen