Structure-based design of HIV protease inhibitors: sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones as non-peptidic inhibitors.
Thaisrivongs
S
S
Upjohn, Inc., Kalamazoo, Michigan 49001, USA.
Skulnick
H I
HI
Turner
S R
SR
Strohbach
J W
JW
Tommasi
R A
RA
Johnson
P D
PD
Aristoff
P A
PA
Judge
T M
TM
Gammill
R B
RB
Morris
J K
JK
Romines
K R
KR
Chrusciel
R A
RA
Hinshaw
R R
RR
Chong
K T
KT
Tarpley
W G
WG
Poppe
S M
SM
Slade
D E
DE
Lynn
J C
JC
Horng
M M
MM
Tomich
P K
PK
Seest
E P
EP
Dolak
L A
LA
Howe
W J
WJ
Howard
G M
GM
Watenpaugh
K D
KD
D018360:Crystallography, X-Ray; D015195:Drug Design; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis*; D008958:Models, Molecular; D011487:Protein Conformation; D011753:Pyrones / Q000737:chemistry*; D013237:Stereoisomerism; D013449:Sulfonamides / Q000737:chemistry*
D017320:HIV Protease Inhibitors; D011753:Pyrones; D013449:Sulfonamides