The use of scopolamine in the treatment of detrusor instability.
OBJECTIVE
A prospective randomized double-blind study was done to evaluate the efficiency of transdermal scopolamine in the treatment of detrusor instability.


METHODS
A total of 20 female patients with detrusor instability was assigned randomly into 2 groups of 10 each. The study group received 4 transdermal scopolamine dermal patches postauricularly, while in the control group placebo patches were applied. Both groups were similar regarding patient age, parity, duration of symptoms and previous anti-incontinence surgery.


RESULTS
The patients were reassessed after 14 days. Improvement in complaints of diurnal frequency (p < 0.05), nocturia (p < 0.005), urgency (p < 0.05) and urge incontinence (p < 0.05) was noted in the study group and not in the control group. A significantly (p < 0.05) less pressure increase on filling and a decreased volume at which pressure exceeded 15 cm. water (p < 0.05) were noted on cystometry in the study group only. No significant side effects were reported and no patient discontinued treatment.


CONCLUSIONS
Transdermal scopolamine was effective and safe in the treatment of female patients with detrusor instability.
Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin, Israel.
Y
Y
Muskat
I
I
Bukovsky
D
D
Schneider
R
R
Langer
D000279:Administration, Cutaneous; D000328:Adult; D018680:Cholinergic Antagonists / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008875:Middle Aged; D009130:Muscle, Smooth / Q000503:physiopathology; D011446:Prospective Studies; D012601:Scopolamine / Q000008:administration & dosage*; D001743:Urinary Bladder / Q000503:physiopathology; D014549:Urinary Incontinence / Q000188:drug therapy* / Q000503:physiopathology
D018680:Cholinergic Antagonists; D012601:Scopolamine