[A case of relapsing Guillain-Barré syndrome following Miller Fisher syndrome].
Miller Fisher syndrome (FS) is thought to be a variant of Gullain-Barré syndrome (GBS), both of which rarely relapse. We report a rare case of GBS that followed FS. A 38-year-old woman had ophthalmoplegia, ataxia and areflexia following an upper respiratory tract infection with a diagnosis of FS. Serum anti-GQ1b IgG antibody was found to be increased, but decreased through immunoadsorption as the neurological symptoms of the patient improved. She became completely asymptomatic three months after the onset of FS. Following a common cold two months later, however, she developed weakness of all four limbs and dysesthesia of hands and feet with albuminocytologic dissociation of cerebrospinal fluid, which was consistent with the diagnosis of GBS. Moreover, serum anti-GQ1b IgG antibody had increased again. Anti-GQ1b IgG antibody frequently becomes positive not only in FS but also GBS with ophthalmoplegia. However, the antibody was positive in this particular patient with GBS, even in the absence of ophthalmoplegia. This case suggests that anti-GQ1b IgG antibody might be a common pathogenesis of both FS and GBS.
Department of Neurology, Tokyo Women's Medical College.
A
A
Mochizuki
K
K
Ota
M
M
Iijima
T
T
Yamauchi
M
M
Iwata
D000328:Adult; D001259:Ataxia / Q000209:etiology* / Q000628:therapy; D001323:Autoantibodies / Q000097:blood / Q000302:isolation & purification; D005260:Female; D005732:Gangliosides / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000302:isolation & purification; D007163:Immunosorbent Techniques; D009886:Ophthalmoplegia / Q000209:etiology* / Q000628:therapy; D011129:Polyradiculoneuropathy / Q000209:etiology* / Q000628:therapy; D012021:Reflex, Abnormal; D012026:Reflex, Stretch; D013577:Syndrome
D001323:Autoantibodies; D005732:Gangliosides; D007074:Immunoglobulin G