[Endocrine disorders associated with impaired glucose tolerance].
Endocrine disorders associated with diabetes mellitus are described. When blood glucose control deteriorates, observed endocrine abnormalities are as follows. 1) Blood GH levels increase. This elevation is small but enough to disturb insulin secretion and glucose metabolism. Plama insulin-like growth factor-1 levels decrease in spite of their strong relation with diabetic retinopathy. 2) Blood thyroid hormones show the similarity with low T3 syndrome. 3) Hyporeninemic hypoaldosteronism occurs especially with patients who have hypertension or moderate diabetic complications. 4) Plasma pancreatic glucagon levels are elevated. Amino acids induce hypersecretion but hypoglycemia fails to response normally. Glucose administration shows impaired inhibition or paradoxical hypersecretion. 5) Other plasma levels of pancreatic hormones such as gastrin, secretin, motilin and somatostatin are usually elevated.
Third Department of Medicine, Teikyo University School of Medicine.
Y
Y
Ogino
M
M
Toriumi
K
K
Tanaka
D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000503:physiopathology*; D004700:Endocrine System Diseases / Q000209:etiology / Q000503:physiopathology*; D019382:Human Growth Hormone / Q000378:metabolism; D006854:Hydrocortisone / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D010187:Pancreatic Hormones / Q000378:metabolism; D012084:Renin-Angiotensin System; D013002:Somatomedins / Q000378:metabolism; D013963:Thyroid Hormones / Q000378:metabolism
D010187:Pancreatic Hormones; D013002:Somatomedins; D013963:Thyroid Hormones; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D006854:Hydrocortisone