Normal and abnormal pulmonary ventilation: visualization at hyperpolarized He-3 MR imaging.
To assess the feasibility of helium-3 magnetic resonance (MR) imaging with a three-dimensional fast low-angle shot (FLASH) sequence, He-3 gas (volume, 300 mL; pressure, 3 x 10(5) Pa; polarized up to 45% by means of optimal pumping) was inhaled by five healthy volunteers and five patients with pulmonary diseases. All breath-hold examinations (22-42 seconds) were completed successfully. Normal ventilation was depicted with homogeneous high signal intensity, lesions were depicted as causing defects, and obstructive lung disease was depicted with severely inhomogeneous signal intensity.
Kauczor
H U
HU
Department of Radiology, Johannes Gutenberg-Universität Mainz, Germany.
Hofmann
D
D
Kreitner
K F
KF
Nilgens
H
H
Surkau
R
R
Heil
W
W
Potthast
A
A
Knopp
M V
MV
Otten
E W
EW
Thelen
M
M
D000280:Administration, Inhalation; D000328:Adult; D001980:Bronchi / Q000033:anatomy & histology / Q000473:pathology; D006371:Helium; D006801:Humans; D007554:Isotopes; D008168:Lung / Q000033:anatomy & histology / Q000473:pathology* / Q000502:physiology; D008171:Lung Diseases / Q000175:diagnosis* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D012119:Respiration; D014132:Trachea / Q000033:anatomy & histology / Q000473:pathology
D007554:Isotopes; D006371:Helium