Hepatocyte growth factor/scatter factor-Met signaling in tumorigenicity and invasion/metastasis.
Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic effector of cells expressing the Met tyrosine kinase receptor. While HGF/SF-Met signaling clearly plays a role in a variety of normal cellular process, this signaling pathway has also been implicated in the generation and metastatic spread of tumors. This review discusses in detail several model systems that have been developed to investigate the role of HGF/SF-Met signaling in malignancy and describes additional data regarding the expression of these molecules in human tumors. Collectively the findings support a role for this receptor-ligand pair in human malignancy.
ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, MD 21702, USA.
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M
Jeffers
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S
Rong
G F
GF
Vande Woude
D000818:Animals; D005786:Gene Expression Regulation / Q000235:genetics; D017228:Hepatocyte Growth Factor / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008954:Models, Biological; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D014407:Tumor Cells, Cultured
D017228:Hepatocyte Growth Factor; D011505:Protein-Tyrosine Kinases