Advances in clinical pharmacology and therapeutics: endothelin.
Endothelin-1, a potent endothelium-derived 21-amino acid vasoconstrictor peptide was only discovered relatively recently. Antagonism of its actions may provide an important new approach to the modulation of cardiac and vascular function.
University Department of Medicine, Western General Hospital, Edinburgh.
D E
DE
Newby
D J
DJ
Webb
D000818:Animals; D002318:Cardiovascular Diseases / Q000503:physiopathology; D065128:Endothelin Receptor Antagonists; D019332:Endothelin-1 / Q000502:physiology; D016232:Endothelins / Q000037:antagonists & inhibitors / Q000502:physiology*; D006801:Humans; D051437:Renal Insufficiency / Q000503:physiopathology
D065128:Endothelin Receptor Antagonists; D019332:Endothelin-1; D016232:Endothelins