Responses of serum lipids and adipose tissue lipases to lipopolysaccharide administration in normal and hepatoma-bearing rats.
The effects of in vivo lipopolysaccharide administration on serum lipid metabolism were studied in normal and hepatoma-bearing rats. Changes in serum lipid levels and adipose tissue lipase (lipoprotein lipase and hormone-sensitive lipase) activities following injection of lipopolysaccharide into normal rats resembled those in hepatoma-bearing rats. These results suggest the presence of some common factor(s) involved in the incidence of abnormal lipid metabolism upon lipopolysaccharide injection and hepatoma transplantation.
Department of Applied Biological Science, Tokyo Noko University, Japan.
M
M
Kawasaki
K
K
Yagasaki
Y
Y
Miura
R
R
Funabiki
D000273:Adipose Tissue / Q000187:drug effects / Q000201:enzymology*; D000818:Animals; D006949:Hyperlipidemias / Q000097:blood / Q000201:enzymology / Q000378:metabolism; D008055:Lipids / Q000097:blood*; D008070:Lipopolysaccharides / Q000633:toxicity*; D008071:Lipoprotein Lipase / Q000187:drug effects / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000097:blood / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
D008055:Lipids; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D008071:Lipoprotein Lipase