Synthesis and reactions of some new 4H-pyrano[3,2-c]benzopyran-5-one derivatives and their potential biological activities.
Several new 4H-pyrano[3,2-c]benzopyran-5-ones (6a-g and 10) which exhibited antibacterial and fungicidal activity, have been synthesized via a one flask multicomponent condensation of aldehydes with malononitrile and 4-hydroxycoumarin. The reactions of 6a with several nucleophilic reagents are reported.
Shaker
R M
RM
Chemistry Department, El-Minia University, Egypt.
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects; D001409:Bacillus cereus / Q000187:drug effects; D003374:Coumarins / Q000138:chemical synthesis* / Q000494:pharmacology; D005670:Fusarium / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D011549:Pseudomonas / Q000187:drug effects; D013055:Spectrophotometry, Infrared
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D003374:Coumarins; D007202:Indicators and Reagents