[Postsynaptic density proteins related to the expression and modulation of synaptic plasticity].
One approach to elucidate the mechanism of synaptic plasticity, especially the postsynaptic mechanism, is the analysis of postsynaptic density (PSD). The PSD is an electron-dense cytoskeletal structure apposing the postsynaptic membrane, is a specific device for postsynaptic signal transmission, and attaches a number of molecules that are involved in postsynaptic signal transmission and its regulation. I review in this article the two groups of PSD proteins: Protein kinases (Ca2+/calmodulin-dependent protein kinase II, protein kinase C, mitogen-activated protein kinase, and tyrosine kinases) and molecules that work as messengers from the synapse to the nucleus (MSNs). Protein phosphorylation-dephosphorylation plays a pivotal role in the modulation of synaptic transmission, especially in the early phase of long-term potentiation (LTP). On the other hand, regulation of LTP at a late phase is governed by the new gene expression that is induced by synaptic inputs. For the altered gene expression, synaptic information must be transmitted from the synapse to the nucleus. I have started the search for the MSNs just recently. In this review, I describe several MSN candidates, especially NF-kappa B-like and I kappa B-like molecules.
Department of Neuroplasticity, Shinshu University School of Medicine, Matsumoto, Japan.
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Suzuki
D000818:Animals; D015870:Gene Expression; D016328:NF-kappa B / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009473:Neuronal Plasticity; D010766:Phosphorylation; D011494:Protein Kinases / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000235:genetics; D051841:Transcription Factor RelB; D014157:Transcription Factors
D016328:NF-kappa B; D009419:Nerve Tissue Proteins; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors; C033652:postsynaptic density proteins; D051841:Transcription Factor RelB; D011494:Protein Kinases