A racial difference in the prevalence of the Arg506-->Gln mutation.
Several recent studies have reported that the factor V Arg506-->Gln mutation is present in 3-10% of adults of European descent. To determine if the prevalence is comparable among Blacks, we have initiated a case-control study in a large urban hospital in Atlanta which serves a substantial black population. We have evaluated 131 black subjects with confirmed venous or arterial thrombosis and 61 black subjects without a history of thrombosis. Only one case and one control were positive for the Arg506-->Gln mutation. We conclude that the mutation is more common among Whites than Blacks.
Hooper
W C
WC
National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA, USA.
Dilley
A
A
Ribeiro
M J
MJ
Benson
J
J
Austin
H
H
Silva
V
V
Rawlins
P
P
Wenger
N K
NK
Evatt
B L
BL
D001120:Arginine / Q000235:genetics*; D001483:Base Sequence; D044383:Black People; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics*; D005998:Glycine / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D017354:Point Mutation; D044465:White People
D005165:Factor V; D001120:Arginine; D005998:Glycine