Isolation, characterization and chromosomal assignment of the human WNT7A gene.
The Wnt genes compose a large gene family encoding a group of secreted signaling molecules that have been implicated in oncogenesis and a number of developmental processes. We have isolated a full-length human cDNA clone that we consider to be a novel member of the Wnt gene family. The gene (WNT7A) encodes a deduced 349-amino-acid peptide with 98% identity in amino acid sequence to murine Wnt7a. Expression of this gene is restricted to certain tissues: placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain. Furthermore, we have isolated a genomic clone of WNT7A and mapped it to chromosome 3p25 by fluorescent in situ hybridization.
Laboratory of Molecular Medicine, University of Tokyo, Japan. sikegawa@ims.u-tokyo.ac.jp
S
S
Ikegawa
Y
Y
Kumano
K
K
Okui
T
T
Fujiwara
E
E
Takahashi
Y
Y
Nakamura
D000595:Amino Acid Sequence; D001483:Base Sequence; D015152:Blotting, Northern; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics; D005260:Female; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics*; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins
D018076:DNA, Complementary; D011506:Proteins; D011518:Proto-Oncogene Proteins; C092778:WNT7A protein, human; D051153:Wnt Proteins