Concentration-time profiles of oxytetracycline in blood, kidney and liver of tench (Tinca tinca L) after intramuscular administration.
Oxytetracycline (OTC) is a widely-used antibiotic in several animal species. The Food and Drug Administration allows OTC to be used in fish intended for human food, but there is limited kinetics data available. We studied OTC concentrations in plasma, kidney and liver in tenches (Tinca tinca L) after im administration using HPLC. Concentrations were fit to a monocompartment open model by extended least squares regression analysis using the MULTI (ELS) computer program. Peaks of OTC concentrations (Cmax) occurred at 4 h for blood and kidney and 72 h for liver and were 134.1 micrograms/mL, 129.8 micrograms/g and 333.4 micrograms/g, respectively. There was a high correlation (r = 0.9448) between blood and kidney concentrations and less between blood and liver. Concentrations were statistically different for each system. The blood OTC concentrations were higher than renal concentrations 92% of the time and were higher than hepatic concentrations 29% of the time. The plasma OTC half-life (21.2 h) was longer than in homeothermic species. The tench liver maintains considerable OTC residues and may affect food products derived from that organ.
Universidad de Cordoba, Dpto de Farmacologia Y Toxicologia, Spain.
A
A
Reja
L
L
Moreno
J M
JM
Serrano
D
D
Santiago
F
F
Soler
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D003530:Cyprinidae; D004350:Drug Residues / Q000032:analysis; D006207:Half-Life; D007273:Injections, Intramuscular; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D010118:Oxytetracycline / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D012044:Regression Analysis; D012984:Software; D014018:Tissue Distribution
D000900:Anti-Bacterial Agents; D010118:Oxytetracycline