VIP decelerates non-REM-REM cycles and modulates hormone secretion during sleep in men.
Centrally administered vasoactive intestinal polypeptide (VIP) promotes rapid eye movement (REM) sleep in rats, rabbits, and cats. We studied the effect of 4 x 10 micrograms VIP (expt 1, n = 7) and 4 x 50 micrograms VIP (expt 2, n = 10) administered hourly as intravenous boluses between 2200 and 0100 on sleep electroencephalogram and secretion of plasma adreno corticotropic hormone, cortisol, growth hormone, and prolactin in humans. In experiment 2, the sleep cycles were decelerated during the first three cycles because of increased duration of both REM and non-REM sleep periods, and there was a tendency to increased REM-to-non-REM ratios. With a low VIP dose, prolactin levels were decreased during the whole night, whereas, with a high dose, they were increased during the first half of the night. In experiment 2, the cortisol nadir was advanced, after midnight the serum cortisol levels were enhanced, and the growth hormone peak was blunted. It appears that VIP may have a phase-advancing effect on sleep cycles and cortisol secretion, possibly through actions that involve the suprachiasmatic nucleus.
Department of Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
H
H
Murck
J
J
Guldner
M
M
Colla-Müller
R M
RM
Frieboes
T
T
Schier
K
K
Wiedemann
F
F
Holsboer
A
A
Steiger
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D004702:Endocrine Glands / Q000378:metabolism; D013006:Growth Hormone / Q000097:blood; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007275:Injections, Intravenous; D008297:Male; D011388:Prolactin / Q000097:blood; D012727:Sex Characteristics; D012890:Sleep / Q000187:drug effects* / Q000502:physiology*; D012894:Sleep Stages / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects*; D013997:Time Factors; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D006728:Hormones; D014660:Vasoactive Intestinal Peptide; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D013006:Growth Hormone; D006854:Hydrocortisone