Malignancy-associated pulmonary veno-occlusive disease: report of a case following autologous bone marrow transplantation and review.
Pulmonary veno-occlusive disease (VOD) is a rare cause of pulmonary hypertension (HTN) which has been described in association with a variety of clinical conditions. Rapidly progressive occlusion of pulmonary veins and venules develops that is usually fatal. Recently, a number of cases have been reported in patients with malignancies. To date, 33 patients have developed pulmonary VOD in association with a malignancy or after chemotherapy and/or radiation therapy. Two-thirds of the cases occurred following allogeneic bone marrow transplantation (BMT). We describe the first case of pulmonary VOD following autologous BMT and review the experience of pulmonary VOD in patients with malignancies.
University of Alabama at Birmingham 35294-0006, USA.
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D
Salzman
D R
DR
Adkins
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F
Craig
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C
Freytes
C F
CF
LeMaistre
D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D003606:Dacarbazine / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000628:therapy*; D008297:Male; D011668:Pulmonary Veno-Occlusive Disease / Q000150:complications / Q000209:etiology* / Q000473:pathology; D019172:Transplantation Conditioning / Q000009:adverse effects; D014182:Transplantation, Autologous
D000970:Antineoplastic Agents; D003606:Dacarbazine