Evidence that brain capillary endothelial cells can be infected with murine leukaemia retrovirus, LP-BM5.
Some mice infected with murine leukaemia retrovirus, LP-BM5 including ecotropic, mink cell focus-inducing murine leukaemia virus, and a replication-defective genome, have been reported to show weakness, ataxia, or selective deficits in spatial learning after developing an immunodeficiency syndrome similar to human AIDS. In the central nervous system, astrocytes and microglial cells have been shown to be infected by this virus. We present here findings that the ecotropic virus and defective genome can infect murine brain capillary endothelial cells, and infected endothelial cells show an impaired function as target cells against myelin basic protein (MBP) specific T cell clone.
Department of Neurology, Niigata University, Japan.
M
M
Tanaka
A
A
Sato
Y
Y
Okada
M
M
Makino
T
T
Tabira
D000818:Animals; D000938:Antigen-Presenting Cells / Q000502:physiology; D002196:Capillaries / Q000276:immunology / Q000473:pathology / Q000821:virology; D002478:Cells, Cultured; D002560:Cerebrovascular Circulation; D004730:Endothelium, Vascular / Q000276:immunology / Q000473:pathology / Q000821:virology*; D007371:Interferon-gamma / Q000494:pharmacology; D009052:Leukemia Virus, Murine; D007942:Leukemia, Experimental; D051379:Mice; D008815:Mice, Inbred Strains; D004676:Myelin Basic Protein / Q000494:pharmacology; D012192:Retroviridae Infections; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects / Q000502:physiology; D014412:Tumor Virus Infections
D004676:Myelin Basic Protein; D007371:Interferon-gamma