Insufficient stocking of poisoning antidotes in hospital pharmacies.
OBJECTIVE
To determine whether antidotes for poisoning and overdose are available in hospitals that provide emergency department care.


METHODS
Written survey of hospital pharmacy directors, each of whom reported the amount currently in stock of 8 different antidotes: antivenin (Crotalidae) polyvalent, cyanide kit, deferoxamine mesylate, digoxin immune Fab, ethanol, naloxone hydrochloride, pralidoxime chloride, and pyridoxine hydrochloride.


METHODS
Pharmacy directors of all hospitals with emergency departments in Colorado, Montana, and Nevada.


METHODS
Proportions of hospitals with insufficient stocking of each antidote, defined as complete lack of the antidote or an amount inadequate to initiate treatment of 1 seriously poisoned 70-kg patient.


RESULTS
Questionnaires were mailed to 137 hospital pharmacy directors and 108 (79%) responded. Only 1 (0.9%) of the 108 hospitals stocked all 8 antidotes in adequate amounts. The rate of insufficient stocking for individual antidotes ranged from 2% (for naloxone) to 98% (for digoxin immune Fab). In a multiple regression analysis, smaller hospital size and lack of a formal review of antidote stocking were independent predictors of the number of antidotes stocked insufficiently.


CONCLUSIONS
Insufficient stocking of antidotes is a widespread problem in Colorado, Montana, and Nevada. Although these states are served by a certified regional poison center, potentially lifesaving antidotes are frequently not available when and where they might be needed to treat a single poisoned patient.
Dart
R C
RC
Rocky Mountain Poison and Drug Center, Denver Department of Health and Hospitals, Denver, CO 80220, USA.
Stark
Y
Y
Fulton
B
B
Koziol-McLain
J
J
Lowenstein
S R
SR
D000704:Analysis of Variance; D000931:Antidotes / Q000600:supply & distribution*; D000997:Antivenins; D003120:Colorado; D003676:Deferoxamine / Q000600:supply & distribution; D004632:Emergency Medical Services; D000431:Ethanol / Q000600:supply & distribution; D007140:Immunoglobulin Fab Fragments; D009009:Montana; D009270:Naloxone / Q000600:supply & distribution; D009505:Nevada; D010607:Pharmacy Service, Hospital; D011220:Pralidoxime Compounds / Q000600:supply & distribution; D012044:Regression Analysis
D000931:Antidotes; D000997:Antivenins; D007140:Immunoglobulin Fab Fragments; D011220:Pralidoxime Compounds; C050199:digoxin antibodies Fab fragments; D009270:Naloxone; D000431:Ethanol; D003676:Deferoxamine; C028797:pralidoxime