Murine thymic lymphoma is associated with a species-specific hematopoietic progenitor cell subpopulation.
Many strains of laboratory mouse are uniquely susceptible to the development of T cell lymphoma/leukemia, either spontaneously or as a result of chemical or radiation exposure. In contrast, T cell leukemias or lymphomas which are relatively uncommon in human populations, are not easily induced by radiation, and are not generally associated with chemotherapy or chemical exposure. Evidence is presented to suggest that differences in the susceptibility to the development of these malignancies is related to subtle but important variations in the regulation of hematopoietic stem cell differentiation between these two species.
Department of Pathology, School of Medicine; and Cancer Center; University of Colorado Health Sciences Center, Denver 80262, USA.
R D
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Irons
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Colagiovanni
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Stillman
D000328:Adult; D000818:Animals; D004852:Epoxy Compounds / Q000633:toxicity*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D007377:Interleukin-3 / Q000494:pharmacology; D008223:Lymphoma / Q000139:chemically induced*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D017207:Rats, Sprague-Dawley; D013045:Species Specificity; D019089:Stem Cell Factor / Q000494:pharmacology; D013953:Thymus Neoplasms / Q000139:chemically induced*
D004852:Epoxy Compounds; D007377:Interleukin-3; D019089:Stem Cell Factor; C024370:3,4-epoxy-1-butene; D016178:Granulocyte-Macrophage Colony-Stimulating Factor