Neuronal activity in the claustrum of the monkey during performance of multiple movements.
1. We studied neuronal activity in the claustrum of monkeys during performance of three different arm movements. We verified recording sites of claustral neurons by histological confirmation of microlesions. For the sake of comparison, we also recorded from the arm area of the precentral motor cortex (MI). Selection of the movements was either visually guided or determined by memorized information. 2. A striking property of claustral neurons is their nonselective relation to the three movements (push, pull, and turn a manipulandum). A vast majority (70%) of movement-related neurons exhibited increase of discharge in relation to all three movements, whereas only 16% were active in relation to one of the three movements. By contrast, about one-half of neurons in the MI were active in relation to a single movement. In both areas, the movement-related activity was similar regardless of whether the movements were selected by visual signals or by memory. 3. The study is the first to reveal involvement of claustral neurons in motor execution, and their activity property suggests that the way they are involved is different from that of MI neurons.
Department of Physiology, Tohoku University School of Medicine, Sendai, Japan.
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Shima
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Hoshi
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Tanji
D000818:Animals; D001479:Basal Ganglia / Q000033:anatomy & histology / Q000502:physiology*; D001931:Brain Mapping; D003216:Conditioning, Operant / Q000502:physiology; D005133:Eye Movements / Q000502:physiology; D005552:Forelimb / Q000294:innervation / Q000502:physiology; D008251:Macaca; D009068:Movement / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D011699:Putamen / Q000502:physiology