Association of perianal fistula and colitis in the German shepherd dog: response to high-dose prednisone and dietary therapy.
Twenty-seven German shepherd dogs with perianal fistulas and histological evidence of colitis were entered in a prospective clinical study to investigate the association between perianal fistula and colitis. Additionally, the response of perianal fistula disease to immunosuppressive doses of prednisone and an alternative protein diet was evaluated. All 27 cases completed the treatment protocol, and perianal fistulas completely resolved in nine (33.3%) cases, improved in nine cases, and remained unchanged in nine cases.
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824, USA.
K R
KR
Harkin
R
R
Walshaw
T P
TP
Mullaney
D000818:Animals; D003092:Colitis / Q000209:etiology / Q000628:therapy / Q000662:veterinary*; D004044:Dietary Proteins / Q000627:therapeutic use*; D004283:Dog Diseases / Q000209:etiology* / Q000473:pathology / Q000628:therapy*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D005402:Fistula / Q000150:complications / Q000628:therapy / Q000662:veterinary*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D010481:Perianal Glands / Q000187:drug effects / Q000473:pathology*; D011241:Prednisone / Q000627:therapeutic use*; D011446:Prospective Studies
D004044:Dietary Proteins; D007166:Immunosuppressive Agents; D011241:Prednisone