Effect of low dietary rubidium on plasma biochemical parameters and mineral levels in rats.
The effects of low dietary rubidium on plasma biochemical parameters and mineral levels in tissues in rats were studied. Eighteen male Wistar rats, weighing about 40 g, were divided into two groups and fed the diets with or without supplemental rubidium (0.54 vs 8.12 mg/kg diet) for 11 wk. Compared to the rats fed the diet with supplemental rubidium, the animals fed the diet without rubidium supplementation had higher urea nitrogen in plasma; lower rubidium concentration in tissues; lower sodium in muscle; higher potassium in plasma, kidney and tibia, and lower potassium in testis; lower phosphorus in heart and spleen; lower calcium in spleen; higher magnesium in muscle and tibia; higher iron in muscle; lower zinc in plasma and testis; and lower copper in heart, liver, and spleen, and higher copper in kidney. These results suggest that rubidium concentration in tissues reflects rubidium intake, and that rubidium depletion affects mineral (sodium, potassium, phosphorus, calcium, magnesium, iron, zinc, and copper) status.
Department of Social Medicine, Graduate School of Medicine, Kyoto University, Konoe-cho Yoshida, Sakyo-ku, Japan.
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K
Yokoi
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M
Kimura
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Y
Itokawa
D000818:Animals; D015415:Biomarkers / Q000097:blood*; D001806:Blood Urea Nitrogen; D004032:Diet; D004912:Erythrocytes / Q000378:metabolism; D005527:Food, Fortified; D008297:Male; D008903:Minerals / Q000378:metabolism; D010281:Parathyroid Hormone / Q000097:blood; D011188:Potassium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012413:Rubidium / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism; D014018:Tissue Distribution / Q000187:drug effects
D015415:Biomarkers; D008903:Minerals; D010281:Parathyroid Hormone; D012964:Sodium; D012413:Rubidium; D011188:Potassium