Structural implications in the function of L-type voltage-dependent calcium channels.
The calcium channels play a key role in controlling many physiological processes in the body. Voltage dependent calcium channels have been extensively characterized in terms of their electrophysiological and pharmacological properties. The L-type voltage-dependent calcium channel is composed of several subunits, from which the alpha 1 subunit is the most important. Recent interest has been focused more on the functional implication of the subunit structures and/or their parts. Therefore, this review will concentrate on the structure-functional studies of the voltage-dependent calcium channel rather than on the progress in the study of their structure and tissue specificity.
Krizanova
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Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovakia.
D000818:Animals; D002121:Calcium Channel Blockers / Q000378:metabolism / Q000494:pharmacology; D015220:Calcium Channels / Q000096:biosynthesis / Q000737:chemistry* / Q000502:physiology*; D020746:Calcium Channels, L-Type; D005260:Female; D006801:Humans; D046911:Macromolecular Substances; D008961:Models, Structural; D009865:Oocytes / Q000502:physiology; D017433:Protein Structure, Secondary; D013329:Structure-Activity Relationship; D014982:Xenopus laevis
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D020746:Calcium Channels, L-Type; D046911:Macromolecular Substances