Correlation of histopathological factor of brain tumor and high thallium-201 uptake in single photon emission computed tomography.
This study was undertaken to investigate the relationship between several histological features and the degree of TI-201 uptake in brain tumors. T1-201 SPECT was performed on 52 patients with intracranial lesions. Histological examinations were carried out to determine the gradation of tumor cell density, vascularization, small-cell density, and matrix loosening, and the presence of necrosis, atypia, mitoses, and endothelial proliferation. The histological findings were classified into three categories. While the early uptake of T1-201 depended on the degree of necrosis of glial tumor, the delayed T1-201 uptake was closely related to the degree of necrosis, tumor cell density, and small-cell density, and may thus be of value for estimating the viability and degree of malignancy of glial tumors. In the non-glial tumors, the early and delayed T1-201 uptakes were closely related to all histological parameters, with the increase of necrosis and vascularization in the tumor tissue being particularly closely related to high uptake levels.
Yoshii
Y
Y
Department of Neurological Surgery, University of Tsukuba.
Moritake
T
T
Yamamoto
T
T
Takano
S
S
Tsuboi
K
K
Hyodo
A
A
Nose
T
T
Satou
M
M
D001254:Astrocytoma / Q000000981:diagnostic imaging / Q000473:pathology; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D002452:Cell Count; D004727:Endothelium / Q000166:cytology; D005909:Glioblastoma / Q000000981:diagnostic imaging / Q000473:pathology; D005910:Glioma / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D008938:Mitosis; D009336:Necrosis; D013794:Thallium Radioisotopes / Q000493:pharmacokinetics; D015899:Tomography, Emission-Computed, Single-Photon
D013794:Thallium Radioisotopes