Two new monoterpene glycosides from ku-ding-cha. Inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT).
Two new monoterpene glycosides, kudingosides A and B, were isolated from Ku-Ding-Cha (Ligustrum pedunculare REHD.), together with a known monoterpene glycoside, (S)-lipedoside B-III, and three known phenylethanoid glycosides. Their structures were elucidated by spectroscopic and chemical means. Kudingosides A and B, and (S)-lipedoside B-III inhibited acyl-CoA: cholesterol acyltransferase (ACAT) with IC50 values of 2.70 x 10(-3)M, 2.88 x 10(-3)M, and 2.69 x 10(-4)M, respectively.
Fukuda
T
T
POLA R&D Laboratories, POLA Corporation, Yokohama, Japan.
Kitada
Y
Y
Chen
X M
XM
Yang
L
L
Miyase
T
T
D000080462:Acyclic Monoterpenes; D002240:Carbohydrate Sequence; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007700:Kinetics; D008969:Molecular Sequence Data; D010084:Oxidation-Reduction; D013056:Spectrophotometry, Ultraviolet; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000528:radiation effects
D000080462:Acyclic Monoterpenes; D004365:Drugs, Chinese Herbal; D004791:Enzyme Inhibitors; D006027:Glycosides; D013729:Terpenes; C102957:kudingoside A; C102958:kudingoside B; D002785:Sterol O-Acyltransferase; C007836:geraniol