title: Effects of nedocromil sodium on inflammation and symptoms in therapeutic studies.
abstract: This review cites clinical evidence demonstrating that nedocromil sodium can reverse the clinical features of airway inflammation in asthma, as shown by decreased bronchial responsiveness, decreased diurnal variation in peak expiratory flow, improved baseline lung function, and a decrease in the frequency and severity of chronic symptoms. Clinical trials have also shown that nedocromil sodium has a statistically significant and clinically relevant effect on daytime and nighttime asthma symptoms within 3 days of starting treatment. On an analysis of relevant trials, the effect on asthmatic cough was significant within 24 hours. This rapid effect on symptoms, together with a reversal of the underlying airways inflammation, is a beneficial combination in the management of asthma.
authors.affiliation: Allergy & Clinical Immunology Division, Johns Hopkins Asthma & Allergy Center, Baltimore, MD 21224-6801, USA.
authors.forename: P S
authors.initials: PS
authors.lastname: Creticos
mesh_terms: D001249:Asthma / Q000188:drug therapy*; D016535:Bronchial Hyperreactivity / Q000188:drug therapy; D002940:Circadian Rhythm; D003371:Cough / Q000188:drug therapy; D006801:Humans; D017835:Nedocromil / Q000627:therapeutic use*; D010366:Peak Expiratory Flow Rate
chemical_list: D017835:Nedocromil