Systemic arterial blood pressure and urine protein/creatinine ratio in dogs with hyperadrenocorticism.
OBJECTIVE
To determine prevalence and severity of systemic arterial hypertension and proteinuria in dogs with naturally developing hyperadrenocorticism and to determine whether these abnormalities resolve with adequate management of the disease.


METHODS
Case series and cohort study.


METHODS
77 dogs with naturally developing hyper-adrenocorticism examined once; 15 dogs examined before and after treatment.


RESULTS
Among dogs examined only once, hypertension was diagnosed in 21 of 26 dogs with untreated pituitary-dependent hyperadrenocorticism (PDH), 17 of 21 with inadequately controlled PDH, 8 of 16 with well-controlled PDH, 10 of 10 with an untreated adrenocortical tumor, and 0 of 4 that had undergone adrenalectomy because of an adrenocortical tumor. Untreated dogs and dogs with inadequately controlled PDH had significantly higher blood pressures than did other dogs. Proteinuria was documented in 12 of 26 dogs with untreated PDH, 5 of 16 with inadequately controlled PDH, 3 of 14 with well-controlled PDH, 5 of 8 with an untreated adrenocortical tumor, and 1 of 3 that had undergone adrenalectomy. Dogs with untreated PDH and dogs with an untreated adrenocortical tumor had higher urine protein/creatinine ratios than did dogs with well-controlled PDH. Among dogs evaluated before and after treatment, blood pressure and urine protein/creatinine ratio did not change in 8 dogs with inadequately controlled hyperadrenocorticism, but decreased in 7 dogs with well-controlled disease.


CONCLUSIONS
Results suggest that systemic hypertension and proteinuria are common in dogs with untreated hyperadrenocorticism and that successful treatment of hyperadrenocorticism will result in resolution of these abnormalities in many, but not all, dogs.
Ortega
T M
TM
Veterinary Medical Teaching Hospital, University of California, Davis 95616, USA.
Feldman
E C
EC
Nelson
R W
RW
Willits
N
N
Cowgill
L D
LD
D000308:Adrenocortical Hyperfunction / Q000150:complications / Q000503:physiopathology / Q000652:urine / Q000662:veterinary*; D000818:Animals; D001794:Blood Pressure; D015331:Cohort Studies; D003404:Creatinine / Q000652:urine*; D004283:Dog Diseases / Q000209:etiology / Q000503:physiopathology* / Q000652:urine; D004285:Dogs; D005260:Female; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary*; D008297:Male; D015995:Prevalence; D011507:Proteinuria / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary*
D003404:Creatinine