title: Design of crossover microcomputer program and application on drug bioequivalence data.
abstract: A simple microcomputer crossover program in BASIC is designed for the purpose of drug bioequivalence studies and other related fields of statistical investigation. An illustration of the application of the program is presented to compare the bioavailability of ibuprofen when administered alone or followed by colestipol hydrochloride or by cholestyramine.
authors.affiliation: Department of Pharmaceutics, King Saud University, Saudi Arabia.
authors.forename: M E
authors.initials: ME
authors.lastname: Abdullah
authors.forename: Y M
authors.initials: YM
authors.lastname: El-Sayed
mesh_terms: D000704:Analysis of Variance; D000837:Anion Exchange Resins / Q000493:pharmacokinetics; D001682:Biological Availability; D002792:Cholestyramine Resin / Q000494:pharmacology; D003084:Colestipol / Q000494:pharmacology; D018592:Cross-Over Studies; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D007052:Ibuprofen / Q000493:pharmacokinetics; D008297:Male; D008838:Microcomputers; D012985:Software Design; D013810:Therapeutic Equivalency
chemical_list: D000837:Anion Exchange Resins; D002792:Cholestyramine Resin; D003084:Colestipol; D007052:Ibuprofen