Increased production of nitric oxide in patients with hemorrhagic fever with renal syndrome--relation to arterial hypotension and tumor necrosis factor.
In 15 consecutive subjects hospitalized with nephropathia epidemica, a European form of hemorrhagic fever with renal syndrome, the plasma concentrations of nitrate plus nitrite, stable metabolites of nitric oxide, were determined. From day 3 of onset of disease the concentrations increased, peak levels being reached on days 5 to 7. Maximal plasma concentrations of nitrate plus nitrite were correlated to the degree of hypotension (r = -0.64, p = 0.02) and levels of tumor necrosis factor (TNF)-alpha (r = 0.51, p = 0.05) and soluble TNF receptors p55 and p75 (r = 0.58, p = 0.03 and r = 0.54, p = 0.04, respectively) but not to levels of interferon-gamma or interleukin-10 (p > 0.05). The results are compatible with the well-known capacity of TNF-alpha to enhance production of nitric oxide, and suggest that nitric oxide may be of physiologic importance in hemorrhagic fever with renal syndrome.
Linderholm
M
M
Dept. of Infectious Diseases, Umeå University, Sweden.
Groeneveld
P H
PH
Tärnvik
A
A
D000328:Adult; D000368:Aged; D005260:Female; D018778:Hantavirus Infections / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007022:Hypotension / Q000150:complications / Q000209:etiology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000032:analysis / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis* / Q000378:metabolism*; D009573:Nitrites / Q000032:analysis / Q000378:metabolism; D010949:Plasma / Q000737:chemistry; D051437:Renal Insufficiency / Q000150:complications*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism* / Q000502:physiology*
D009566:Nitrates; D009573:Nitrites; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide