Inhibitors of bacterial signal peptidase: a series of 6-(substituted oxyethyl)penems.
A series of 6-(substituted oxyethyl)penem esters having the (5S) stereochemistry which are potent inhibitors of Escherichia coli leader peptidase is described. Structure-activity relationships are discussed.
Allsop
A
A
SmithKline Beecham Pharmaceuticals, Betchworth, Surrey, UK.
Brooks
G
G
Edwards
P D
PD
Kaura
A C
AC
Southgate
R
R
D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004926:Escherichia coli / Q000201:enzymology*; D007769:Lactams / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008565:Membrane Proteins; D012697:Serine Endopeptidases / Q000187:drug effects*; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D007769:Lactams; D008565:Membrane Proteins; C102428:allyl 6-(1'-acetoxyethyl)penem-3-carboxylate; C102427:allyl 6-(1'-hydroxyethyl)penem-3-carboxylate; D012697:Serine Endopeptidases; C026515:type I signal peptidase