title: Lack of association of the apoE4 allele with hippocampal sclerosis dementia.
abstract: We determined the apolipoprotein E4 (apoE) genotype in 12 cases of autopsy-confirmed hippocampal sclerosis dementia (HSD), a disorder characterized pathologically by neuronal degeneration, predominantly of temporal lobe structures, without senile plaques or neurofibrillary tangles. The frequency of the apoE4 allele in HSD was 12.5%, similar to that of a control population and significantly different from the approximately 40% found in Alzheimer's disease (AD) (P < 0.001). These observations suggest that apoE4 is not a risk factor for HSD.
authors.affiliation: Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Troncoso
authors.forename: C H
authors.initials: CH
authors.lastname: Kawas
authors.forename: C K
authors.initials: CK
authors.lastname: Chang
authors.forename: M F
authors.initials: MF
authors.lastname: Folstein
authors.forename: J C
authors.initials: JC
authors.lastname: Hedreen
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics / Q000473:pathology; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D003704:Dementia / Q000235:genetics* / Q000473:pathology; D005260:Female; D005838:Genotype; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000235:genetics* / Q000473:pathology; D016612:Paraffin Embedding; D012598:Sclerosis
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E