A role of Ca2+/calmodulin-dependent protein kinase II in the induction of long-term potentiation in hippocampal CA1 area.
Long-term potentiation (LTP) in the CA1 area of the hippocampus is considered to be a synaptic model for learning and memory. The induction of LTP is initiated by activation of the NMDA glutamate receptor in the postsynaptic membrane and a subsequent increase in Ca2+ -influx into the neurons following glutamate release. The action of Ca2+ has been proposed to be mediated by Ca2+ -dependent protein kinases. Recent studies indicate that, among the protein kinases, Ca2+/calmodulin-dependent protein kinase II is implicated in the induction of LTP in the hippocampus.
Miyamoto
E
E
Department of Pharmacology, Kumamoto University School of Medicine, Japan. emiyamot@gpo.kumamoto-u.ac.jp
Fukunaga
K
K
D000818:Animals; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism / Q000502:physiology*; D006624:Hippocampus / Q000201:enzymology / Q000502:physiology*; D006801:Humans; D017774:Long-Term Potentiation / Q000502:physiology*
D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases