Sleep cycle disturbances induced by apamin, a selective blocker of Ca(2+)-activated K+ channels.
Intracerebroventricular injections of low doses of apamin, a specific blocker of a class of Ca(2+)-activated K+ channels, induced insomnia and a long-lasting suppression of deep slow sleep and paradoxical sleep. Injected animals showed a late but important rebound of paradoxical sleep. Even after the recovery of a normal sleep amount, the circadian cycle remained disturbed during all the recording duration (96 h).
Gandolfo
G
G
Laboratoire de Psychophysiologie, Faculté des Sciences, Nice Cedex 2, France.
Schweitz
H
H
Lazdunski
M
M
Gottesmann
C
C
D000818:Animals; D001030:Apamin / Q000008:administration & dosage / Q000494:pharmacology*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D002940:Circadian Rhythm; D007276:Injections, Intraventricular; D008297:Male; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D024681:Potassium Channels, Calcium-Activated; D051381:Rats; D017208:Rats, Wistar; D007319:Sleep Initiation and Maintenance Disorders; D012894:Sleep Stages / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects; D051640:Small-Conductance Calcium-Activated Potassium Channels; D014851:Wakefulness / Q000187:drug effects
D026902:Potassium Channel Blockers; D015221:Potassium Channels; D024681:Potassium Channels, Calcium-Activated; D051640:Small-Conductance Calcium-Activated Potassium Channels; D001030:Apamin