title: The effects of antifungal agents on the morphogenetic transformation by Candida albicans in vitro.
abstract: The effects of antifungal agents, with different mechanisms of action, on the morphogenetic transformation by synchronised yeast-phase Candida albicans cells in vitro and their respective anti-Candida activities are described. MIC data demonstrated that the azoles, amphotericin B and echinocandin were the most active agents against four C. albicans strains. Morphogenetic transformation experiments demonstrated that amphotericin B was significantly better at preventing the transformation, under a variety of test conditions, than the azoles and flucytosine: amphotericin B abolished the transformation at low concentrations while the azoles only prevented the morphogenetic transformation at much higher concentrations (> 100 x MIC).
authors.affiliation: Lepetit Research Center, Marion Merrell Dow Research Institute, Varese, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Hawser
authors.forename: M
authors.initials: M
authors.lastname: Francolini
authors.forename: K
authors.initials: K
authors.lastname: Islam
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000235:genetics; D018929:Cell Culture Techniques / Q000379:methods; D002453:Cell Cycle / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009024:Morphogenesis / Q000187:drug effects; D014170:Transformation, Genetic / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents