Low adrenal androgen output in patients with abnormal laryngeal epithelium.
We present 16 new patients who had abnormal vocal cord biopsies. Each had a serum sex hormone profile performed on the morning of the procedure. The striking abnormality was that 12 (75%) had low dehydroepiandrosterone sulphate (DHEAS), the main adrenal androgen, and four of these had prepubertal levels.
Colquhoun-Flannery
W
W
Department of Otolaryngology, Head and Neck Surgery, Southampton General Hospital, UK.
Carruth
J A
JA
D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001706:Biopsy; D002278:Carcinoma in Situ / Q000097:blood* / Q000473:pathology; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000097:blood* / Q000473:pathology; D007827:Laryngitis / Q000097:blood* / Q000473:pathology; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010865:Pilot Projects; D013739:Testosterone / Q000097:blood; D014827:Vocal Cords / Q000473:pathology*
D014408:Biomarkers, Tumor; D013739:Testosterone; D019314:Dehydroepiandrosterone Sulfate; D007986:Luteinizing Hormone