Cancer risk assessment for crystalline silica to implement California's hot spots act.
Crystalline silica has been identified as a probable human carcinogen. To assess the potential for adverse health effects due to environmental exposures to respirable crystalline silica, a quantitative estimate of carcinogenicity has been made using incidence data from three studies in which long-term silica inhalation caused lung tumors in rats. The uncertainties in risk assessment in general and in the risk assessment for silica in particular are discussed.
Collins
J F
JF
Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Berkeley 94704, USA.
Marty
M A
MA
D000818:Animals; D002140:California; D002273:Carcinogens; D003460:Crystallization; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D016273:Occupational Exposure / Q000009:adverse effects*; D011050:Policy Making; D051381:Rats; D011916:Rats, Inbred F344; D017207:Rats, Sprague-Dawley; D018570:Risk Assessment; D017678:Sex Distribution; D012822:Silicon Dioxide / Q000009:adverse effects* / Q000494:pharmacology
D002273:Carcinogens; D012822:Silicon Dioxide