title: Synthesis and characterization of metal(II)-8-quinolinsulfonamidato (sa-) complexes (M = Co, Ni, Cu, and Zn). Crystal structure of [Zn(sa)2(NH3)]NH3 complex. Carbonic anhydrase inhibitory properties.
abstract: A new sulfonamide, 8-quinolinsulfonamide(Hsa), has been prepared and examined as a chelating agent towards metal(II) ions. The spectroscopic properties of the M(II) sulfonamidato complexes has been studied. The inhibitory properties of the ligand and the synthesised complexes were tested. The crystal structure of the [Zn(sa)2(NH3)].NH3 complex was determined by single-crystal X-ray diffraction. Crystal data of the zinc(II) complex: a = 16.217(4)A, b = 8.041(1)A, c = 15.606(4)A, beta = 95.75(1) degrees, Z = 4, and V = 2024.6(7)A3. The refinement of the structure based on 6047 reflections attained to R = 0.049 and Rw = 0.052. The zinc(II) ion is surrounded by four N atoms of two sulfonamidato ligands and one N atom of an ammonia molecule in an trigonal bipyramid arrangement.
authors.affiliation: Departamento de Química Inorgánica, Universidad de Valencia, Spain.
authors.forename: S L
authors.initials: SL
authors.lastname: Sumalan
authors.forename: J
authors.initials: J
authors.lastname: Casanova
authors.forename: G
authors.initials: G
authors.lastname: Alzuet
authors.forename: J
authors.initials: J
authors.lastname: Borrás
authors.forename: A
authors.initials: A
authors.lastname: Castiñeiras
authors.forename: C T
authors.initials: CT
authors.lastname: Supuran
mesh_terms: D002257:Carbonic Anhydrase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D002614:Chelating Agents; D009942:Organometallic Compounds; D013449:Sulfonamides