[Allelic chromosomal deletion using microsatellite polymorphism--the clue to the positional cloning of the tumor suppressor genes responsible for gastric carcinoma].
Cancers are caused by an accumulation of multiple genetic lesions that we are now beginning to understand. Gastric cancer has a different morphological appearance, ability to invade or metastasize, and response to treatment. The pattern of loss of heterozygosity is similar, but not necessarily the same among the different pathological lesions. It is likely that several unknown tumor suppressor genes could be participate in tumor behavior. Positional cloning using microsatellite genes would facilitate the identification of such additional tumor suppressor genes in the genome.
Sato
J
J
Institute of Clinical Medicine, University of Tsukuba.
Fukutomi
H
H
D000483:Alleles; D003001:Cloning, Molecular; D017353:Gene Deletion; D016147:Genes, Tumor Suppressor; D006579:Heterozygote; D006801:Humans; D018895:Microsatellite Repeats; D013274:Stomach Neoplasms / Q000235:genetics*