title: Dissemination of Leishmania (Viannia) braziliensis.
abstract: Destructive human mucocutaneous leishmaniasis may appear many years after the primary cutaneous infection with Leishmania (Viannia) braziliensis. Hamsters (Mesocricetus auratus) were infected with metacyclic L. braziliensis promastigotes. It was found that secondary metastatic visceral lesions could arise from a primary cutaneous lesion, or secondary cutaneous lesions from a primary visceral lesion. Parasites in the viscera were shown to be viable, multiplying and capable of metastasis to either secondary visceral or cutaneous sites. The finding of an early metastasis in the wall of a small cutaneous vessel indicates that dissemination can occur by the haematogenous route. Slow growing organisms in viscera may thus be a source for late metastasis to mucocutaneous sites or for systemic relapse after immunosuppression.
authors.affiliation: Laboratorios de Parasitologica e Patologia, Universidade de Brasilia, Brazil.
authors.forename: M C
authors.initials: MC
authors.lastname: Almeida
authors.forename: C A
authors.initials: CA
authors.lastname: Cuba-Cuba
authors.forename: M A
authors.initials: MA
authors.lastname: Moraes
authors.forename: M A
authors.initials: MA
authors.lastname: Miles
mesh_terms: D000818:Animals; D006224:Cricetinae; D005260:Female; D007892:Leishmania braziliensis; D016773:Leishmaniasis, Cutaneous / Q000473:pathology*; D007898:Leishmaniasis, Visceral / Q000473:pathology*; D008099:Liver / Q000473:pathology; D008297:Male; D012008:Recurrence; D012867:Skin / Q000473:pathology