[Immunologic monitoring and immune reconstitution in recipients of allogeneic bone marrow].
The dynamics of different peripheral blood lymphocyte subpopulations (CD3+, CD4+, CD8+, CD22+, DR+, CD25+ and CD16+) and levels of serum cytokines TNFa and IL1 beta were evaluated in 10 patients with allogeneic bone marrow transplantation (BMT). It was established that initially low levels of practically all the lymphoid subsets studied came back to normal in patients with favorable post-BMT course, while, in unfavorable post-BMT course (GVHD or relapse), the levels of said lymphoid subsets remained unchanged or even dropped. Post-BMT increase in serum TN alpha level can be of prognostic value for GVHD development whereas serum IL1 beta level does not correlate with post-BMT course.
Bubnova
L N
LN
Glazanova
T V
TV
Rozanova
O E
OE
Pavlova
I E
IE
Moiseev
S I
SI
Abdulkadyrov
K M
KM
D016026:Bone Marrow Transplantation / Q000276:immunology*; D018791:CD4 Lymphocyte Count; D016516:CD4-CD8 Ratio; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000097:blood; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D018655:Lymphocyte Count; D015166:Monitoring, Immunologic; D011237:Predictive Value of Tests; D011379:Prognosis; D012008:Recurrence; D014184:Transplantation, Homologous; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha