Recognition of immunoglobulin A1 by oral actinomyces and streptococcal lectins.
Actinomyces naeslundii and Streptococcus gordonii, oral bacteria that possess Gal/GalNAc- and sialic acid-reactive lectins, respectively, were adherent to immobilized secretory immunoglobulin A (IgA) and two IgA1 myeloma proteins but not to two IgA2 myeloma proteins. Apparently, O-linked oligosaccharides at the hinge region of the IgA1 heavy chain are receptors for lectin-mediated adhesion of these bacteria.
Ruhl
S
S
Laboratory of Microbial Ecology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA.
Sandberg
A L
AL
Cole
M F
MF
Cisar
J O
JO
D000190:Actinomyces / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D037102:Lectins / Q000276:immunology*; D009055:Mouth / Q000382:microbiology; D009194:Myeloma Proteins / Q000276:immunology*; D013291:Streptococcus / Q000276:immunology*
D007070:Immunoglobulin A; D037102:Lectins; D009194:Myeloma Proteins