title: The effect of age and sex on the expression of prolactin binding activity in the chicken bursa of Fabricius.
abstract: The binding of 125I-labeled prolactin (PRL) to membranes from the bursa of Fabricius of male and female chicks of different ages (15-30-45 and 60 days) was studied. In male chicks the binding was very low in 15 day-old animals and slightly increased in more aged animals. In female chicks the binding was more evident in young animals and decreased in 60 day-old animals. The binding showed a hormonal specificity and Scatchard analysis of the binding revealed the presence of binding sites with low capacity and high affinity. The presence of PRL receptors in the bursa of the chick, a structure that confers immunological competence to birds, gives further support to the involvement of the hormone in the immune processes.
authors.affiliation: Dipartimento di Farmacologia Sperimentale, Funzioni e Tecnologie Biologiche, Università di Napoli Federico II, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Di Carlo
authors.forename: R
authors.initials: R
authors.lastname: Meli
authors.forename: S
authors.initials: S
authors.lastname: Florio
authors.forename: G
authors.initials: G
authors.lastname: Mattace Raso
authors.forename: O
authors.initials: O
authors.lastname: Gualillo
authors.forename: G
authors.initials: G
authors.lastname: Pagnini
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D002060:Bursa of Fabricius / Q000378:metabolism*; D002645:Chickens; D005260:Female; D008297:Male; D011388:Prolactin / Q000378:metabolism*; D011981:Receptors, Prolactin / Q000378:metabolism*; D012727:Sex Characteristics
chemical_list: D011981:Receptors, Prolactin; D011388:Prolactin