title: ICE-like proteases execute the neuronal death program.
abstract: The past year has witnessed significant advances in our understanding of the mechanisms that kill neurons during programmed cell death. The executioners are members of a family of proteases founded by ced-3, the product of a gene that is required for programmed cell death in the nematode Caenorhabditis elegans, and by mammalian interleukin-1 beta-converting enzyme. These proteases represent interesting novel targets for the therapy of acute and chronic pathologies of the nervous system associated with neuronal death.
authors.affiliation: Geneva Biomedical Research Institute, Glaxo Wellcome Research and Development S.A, Switzerland. jcm26619@ggr.co.uk
authors.forename: J C
authors.initials: JC
authors.lastname: Martinou
authors.forename: R
authors.initials: R
authors.lastname: Sadoul
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis; D001665:Binding Sites; D017173:Caenorhabditis elegans; D002154:Calpain / Q000378:metabolism; D020170:Caspase 1; D003546:Cysteine Endopeptidases / Q000737:chemistry / Q000378:metabolism*; D004789:Enzyme Activation; D008322:Mammals; D008959:Models, Neurological; D009097:Multienzyme Complexes / Q000378:metabolism; D009474:Neurons / Q000166:cytology* / Q000502:physiology*; D046988:Proteasome Endopeptidase Complex
chemical_list: D009097:Multienzyme Complexes; D002154:Calpain; D003546:Cysteine Endopeptidases; D020170:Caspase 1; D046988:Proteasome Endopeptidase Complex