Acute liver injury and octreotide.
Octreotide is a synthetic analogue of somatostatin with therapeutic applications in a variety of endocrine and gastrointestinal disorders. We report a patient with acromegaly who developed acute hepatocellular liver injury after receiving two 0.1-mg doses of octreotide. The drug causality was confirmed by rechallenge. To our knowledge this is the second reported case in the literature.
González-Martín
J A
JA
Gastroenterology Section, Hospital Virgen de la Luz, Cuenca, Spain.
Donnay
S
S
Morillas
J
J
Gómez-Aparicio
C
C
Garcia-Cano
J
J
Pérez-Vigara
G
G
Roldán
A
A
D000172:Acromegaly / Q000188:drug therapy / Q000209:etiology; D000236:Adenoma / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015282:Octreotide / Q000009:adverse effects* / Q000627:therapeutic use; D010911:Pituitary Neoplasms / Q000150:complications / Q000188:drug therapy / Q000601:surgery
D018931:Antineoplastic Agents, Hormonal; D015282:Octreotide