Evaluation of anti-inflammatory potential of fixed oil of Ocimum sanctum (Holybasil) and its possible mechanism of action.
The fixed oil of Ocimum sanctum (Labiatae) was found to possess significant anti-inflammatory activity against carrageenan- and different other mediator-induced paw edema in rats. Significant inhibitory effect was also observed in castor oil-induced diarrhoea in rats. It also inhibited arachidonic acid and leukotriene-induced paw edema. The results of anti-inflammatory activity of Ocimum sanctum support the dual inhibition of arachidonate metabolism as indicated by its activity in inflammation models that are insensitive to selective cyclooxygenase inhibitors. On the basis of the findings it may be inferred that Ocimum sanctum may be a useful anti-inflammatory agent which blocks both the pathways, i.e. cyclooxygenase and lipoxygenase, or arachidonic acid metabolism.
Singh
S
S
College of Pharmacy (University of Delhi), New Delhi, India.
Majumdar
D K
DK
Rehan
H M
HM
D000315:Adrenalectomy; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D016718:Arachidonic Acid / Q000378:metabolism* / Q000633:toxicity; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003967:Diarrhea / Q000188:drug therapy; D004195:Disease Models, Animal; D004487:Edema / Q000188:drug therapy; D015289:Leukotrienes / Q000633:toxicity; D016859:Lipoxygenase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D000893:Anti-Inflammatory Agents; D016861:Cyclooxygenase Inhibitors; D015289:Leukotrienes; D016859:Lipoxygenase Inhibitors; D010938:Plant Oils; D016718:Arachidonic Acid