title: [Correlation between int-2 oncogene amplification and increased tumor size in breast cancer].
abstract: Amplification of the int-2 oncogene was observed in 10 out of 78 (13%) samples of DNA isolated from cells of primary breast tumor. A clinico-morphological examination established a correlation between this molecular-genetical anomaly and tumor size: gene amplification was detected in 1 out 34 (3%) cases of breast tumor under 2 cm and in 9 out 44 (20%) tumors measuring 2 cm and more (p < 0.05). Similarly, a kind of correlation was found between gene amplification and low differentiation of breast cancer cells: enhanced copying ability of the oncogene was registered in 2 out 4 (50%) breast tumors with low cell differentiation, 8 out 69 (12%) tumors with medium cell differentiation, while it was not identified in 5 breast carcinomas with high cell differentiation (p < 0,2).
authors.forename: O I
authors.initials: OI
authors.lastname: Chernitsa
authors.forename: O I
authors.initials: OI
authors.lastname: Laur
authors.forename: E N
authors.initials: EN
authors.lastname: Imianitov
authors.forename: I V
authors.initials: IV
authors.lastname: Cheburkin
authors.forename: E V
authors.initials: EV
authors.lastname: Belogubova
authors.forename: E S
authors.initials: ES
authors.lastname: Iliushik
authors.forename: O A
authors.initials: OA
authors.lastname: Zaĭtseva
authors.forename: A V
authors.initials: AV
authors.lastname: Togo
authors.forename: O A
authors.initials: OA
authors.lastname: Ivanova
authors.forename: P G
authors.initials: PG
authors.lastname: Kniazev
authors.forename: V F
authors.initials: VF
authors.lastname: Semiglazov
authors.forename: K P
authors.initials: KP
authors.lastname: Khanson
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D005260:Female; D005346:Fibroblast Growth Factors / Q000235:genetics; D005784:Gene Amplification; D006801:Humans; D009857:Oncogenes / Q000235:genetics*
chemical_list: D005346:Fibroblast Growth Factors