Pathogenesis and prevention of stomach cancer.
In many Western developed countries, the incidence of stomach cancer has declined dramatically. This decrease was an extraordinary, "unplanned triumph", especially when compared to other cancers. Stomach cancer is still the most prevalent malignant tumor in Korea. Most Koreans carry Helicobacter pylori in their stomach. Thus, a new hypothesis, based on the relationship between the host and Helicobacter pylori, is presented as the carcinogenesis of human stomach cancer. The reasons for why the N-nitrosamide hypothesis should be dismissed as the etiology of stomach cancer, and why the contemporarily available principles and practice of intervention strategies to rapidly decrease the surprisingly high prevalence rate of Helicobacter pylori infection are impractical at this moment, are explained. In order to introduce an alternative provisional strategy of the "planned triumph" for the population vulnerable to stomach cancer, vitamin C is defined as an anti-inflammatory agent on the basis of the pathogenesis of Helicobacter pylori infection.
Youn
H S
HS
Department of Microbiology, Gyeongsang National University College of Medicine, Chinju, Kyung-Nam, Korea.
Ko
G H
GH
Chung
M H
MH
Lee
W K
WK
Cho
M J
MJ
Rhee
K H
KH
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D016481:Helicobacter Infections / Q000517:prevention & control*; D016480:Helicobacter pylori / Q000502:physiology*; D006801:Humans; D009603:Nitroso Compounds / Q000378:metabolism; D013274:Stomach Neoplasms / Q000382:microbiology*
D009603:Nitroso Compounds; C013621:nitrosamides; D001205:Ascorbic Acid