title: Cytotoxic triterpenes from a marine sponge, Stelletta sp.
abstract: Bioassay-guided fractionation of an extract of a marine sponge, Stelletta sp., has led to the isolation and characterization of four new cytotoxic isomalabaricane triterpenes, named stellettins C (1), D (2), E (3), and F (4). Three known triterpenes (5-7) were also isolated from the same extract. The most sensitive of the tested cell lines (e.g., leukemia, central nervous system, renal) generally responded with GI50 concentrations in the low-to-mid nanomolar range.
authors.affiliation: Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: McCormick
authors.forename: T C
authors.initials: TC
authors.lastname: McKee
authors.forename: J H
authors.initials: JH
authors.lastname: Cardellina
authors.forename: M
authors.initials: M
authors.lastname: Leid
authors.forename: M R
authors.initials: MR
authors.lastname: Boyd
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D014315:Triterpenes