title: Genetic interactions among vestigial, hairy, and Notch suggest a role of vestigial in the differentiation of epidermal and neural cells of the wing and halter of Drosophila melanogaster.
abstract: In this paper we describe the results of genetic analysis of the vestigial locus by studying its interactions with hairy and Notch loci in Drosophila melanogaster. Different vestigial alleles in homo- and heterozygous combination with different hairy alleles show synergism in increasing both cell death and formation of ectopic bristles and produce ectopic veins. Interactions between N and vg also show synergism in increasing cell death and formation of ectopic bristles. Only synergism in cell death is seen between h and N. The interactions indicate that vg product plays a role in the differentiation of epidermal and neural cells of the wing disc by interacting with N and h products either directly or indirectly. Mechanisms of molecular interactions among the three loci are discussed.
authors.affiliation: Department of Biology, University of Bologna, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Abu-Issa
authors.forename: S
authors.initials: S
authors.lastname: Cavicchi
mesh_terms: D000818:Animals; D016923:Cell Death; D002454:Cell Differentiation / Q000235:genetics; D002874:Chromosome Mapping; D004331:Drosophila melanogaster / Q000033:anatomy & histology / Q000235:genetics*; D000078404:Epidermal Cells; D017344:Genes, Insect; D009154:Mutation; D004856:Postural Balance; D014921:Wings, Animal / Q000166:cytology / Q000294:innervation*