Pressor effects elicited from the periaqueductal grey, and dorsal and ventrolateral medulla in cats are independent from cerebellar mechanisms.
Cats were anesthetized with chloralose (35 mg/kg, i.p.) and urethane (350 mg/kg, i.p.). In 5 cats, the pressor regions of periaqueductal grey (PAG) of the midbrain were stimulated electrically (rectangular pluses, 80 Hz, 0.5 ms, 100-150 microA). In another 6 cats, the pressor regions of both dorsal medulla (DM) and ventrolateral medulla (VLM) previously located by electrical stimulation in the same cat were stimulated by sodium glutamate (Glu, 0.25 M, 100 nl). After control stimulation, the superior, middle and inferior cerebellar peduncles on both sides were transected while the stimulating electrodes were maintained in the same position. Changes of systemic arterial pressure (SAP) and plasma norepinephrine (NE) and epinephrine (EP) following stimulations of the PAG, DM or VLM were compared before and after transections. It was found that the transection did not cause significant changes in the resting SAP and plasma NE and EP and also the induced pressor responses, namely the increases of above parameters. Findings suggest that the sympathetic vasomotor effect and adrenomedullary secretion resulted from stimulations of both DM and VLM and possibly PAG are independent from the cerebellar mechanism.
Chai
C Y
CY
Institute of Biomedical Sciences, Academia Sinica, Taichung Veterans General Hospital, Taiwan, Republic of China.
Yen
K D
KD
Cheng
F C
FC
Kuo
J S
JS
D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D002415:Cats; D002531:Cerebellum / Q000502:physiology*; D003655:Decerebrate State; D004558:Electric Stimulation; D004837:Epinephrine / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D008297:Male; D008636:Mesencephalon / Q000502:physiology*; D009638:Norepinephrine / Q000097:blood; D010487:Periaqueductal Gray / Q000502:physiology*
D009638:Norepinephrine; D004837:Epinephrine