title: Rapid and high-performance analysis of thyreostatic drug residues in urine using gas chromatography-mass spectrometry.
abstract: A more sensitive method was developed using the hyphenated technique of gas chromatography-mass spectrometry (GC-MS) supplementary to the official high-performance thin-layer chromatography (HPTLC) method. Even combined with less efficient extraction and clean-up methods, GC-MS is able to lower the detection limit to less than 50 ppb. The powerful technique of GC-MS-MS is tried out to reduce the detection limit even more, in combination with simplified extraction methods. This time-saving approach combined with the increase in sensitivity is of great importance for a routine technique.
authors.affiliation: Department of Veterinary Food Inspection, Faculty of Veterinary Medicine, University of Ghent, Merelbeke, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Batjoens
authors.forename: H F
authors.initials: HF
authors.lastname: De Brabander
authors.forename: K
authors.initials: K
authors.lastname: De Wasch
mesh_terms: D013956:Antithyroid Agents / Q000737:chemistry / Q000652:urine*; D004350:Drug Residues / Q000032:analysis* / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry; D008713:Methimazole / Q000737:chemistry / Q000652:urine*; D008779:Methylthiouracil / Q000737:chemistry; D012680:Sensitivity and Specificity; D013997:Time Factors
chemical_list: D013956:Antithyroid Agents; D008713:Methimazole; D008779:Methylthiouracil