title: Progressive ECG changes in arrhythmogenic right ventricular disease. Evidence for an evolving disease.
abstract: Electrocardiography results were used to assess diagnosis and evolution of arrhythmogenic right ventricular disease. The initial ECG presentation and long-term changes were analysed in 74 consecutive patients with symptomatic ventricular tachycardia and arrhythmogenic right ventricular disease. On first available tracings, a left axis deviation of the QRS was found in 18 patients. The QRS length in V1 was > or = 110 ms in 39 patients, an epsilon wave was present in 17, and a complete right bundle branch block in four patients. The T wave was negative in V1-V3 in 37 patients (50%). In 36 patients, long-term electrocardiographic follow-up of 9.5 +/- 3.2 years was available. During this period, ECG changes were observed in 20 patients (56%): negative T waves in 11 patients, a new left axis deviation in three, QRS enlargement in 13 (including eight right bundle branch block), right atrial hypertrophy in three, and paroxysmal or established atrial fibrillation in three. On studying all 110 ECG tracings (74 initial recordings +36 follow-up ECGs), we found a strong correlation between QRS or T wave changes and the length of follow-up after the first symptom; mean time interval between first ventricular tachycardia and ECG recording was significantly longer in patients with negative T waves in the right precordial leads, QRS enlargement, or left axis deviation, than in patients without such abnormalities. ECG abnormalities were more frequent at 10 year and 5 year follow-up than on initial tracings. A normal ECG was found in 40% of patients during the first year of follow-up, 8% at 5 years, and never later than the 6th year. In conclusion, electrocardiographic diagnosis of arrhythmogenic right ventricular disease may be difficult in the initial stage of the disease, since a normal ECG is found in up to 40% of patients. During the follow-up, progressive and characteristic ECG changes will occur. Arrhythmogenic right ventricular disease can be excluded if the ECG is found to be normal 6 years or later after a first ventricular tachycardia attack.
authors.affiliation: Cardiology Department, Lariboisière Hospital, Paris, France.
authors.forename: S A
authors.initials: SA
authors.lastname: Jaoude
authors.forename: J F
authors.initials: JF
authors.lastname: Leclercq
authors.forename: P
authors.initials: P
authors.lastname: Coumel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000175:diagnosis*; D002648:Child; D018450:Disease Progression; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D018497:Ventricular Dysfunction, Right / Q000175:diagnosis*