Antipsychotic drug effects in a model of schizophrenic attentional disorder: a randomized controlled trial of the effects of haloperidol on latent inhibition in healthy people.
We studied the effects of haloperidol (0.5 mg, intravenously) on latent inhibition in an auditory paradigm and two visual paradigms in healthy subjects. Haloperidol increased latent inhibition in one visual paradigm and tended to increase latent inhibition in an auditory task, compared to saline-injected controls. These results indicate that haloperidol can enhance the selectivity of attention. In contrast, previous studies have reported that acute schizophrenics show reduced latent inhibition.
Williams
J H
JH
Department of Pharmacology, University of Oxford, United Kingdom.
Wellman
N A
NA
Geaney
D P
DP
Cowen
P J
PJ
Feldon
J
J
Rawlins
J N
JN
D000161:Acoustic Stimulation; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001288:Attention / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D004311:Double-Blind Method; D006220:Haloperidol / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007275:Injections, Intravenous; D008960:Models, Psychological; D010775:Photic Stimulation; D011930:Reaction Time / Q000187:drug effects; D013216:Reflex, Startle / Q000187:drug effects*; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents; D006220:Haloperidol