Benzophenone synthase from cultured cells of Centaurium erythraea.
A central step in xanthone biosynthesis is the formation of the C13 skeleton, i.e. an intermediate benzophenone. Biosynthesis of 2,3',4,6-tetrahydroxybenzophenone from m-hydroxybenzoyl-CoA and malonyl-CoA was shown in cell-free extracts from cultured cells of Centaurium erythraea. The enzyme catalyzing this reaction was named benzophenone synthase.
Beerhues
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Institut für Pharmazeutische Biologie, Bonn, Germany.
D000214:Acyl Coenzyme A / Q000378:metabolism; D019735:Carbon-Carbon Ligases; D002474:Cell-Free System; D002478:Cells, Cultured; D004229:Dithiothreitol / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008025:Ligases / Q000302:isolation & purification / Q000378:metabolism*; D010944:Plants / Q000201:enzymology*; D013379:Substrate Specificity; D013816:Thermodynamics
D000214:Acyl Coenzyme A; D008025:Ligases; D019735:Carbon-Carbon Ligases; C098887:benzophenone synthase; D004229:Dithiothreitol