Vaccination against cestode parasites.
Cestode parasites are important because they cause production losses, particularly in the sheep, beef and pig meat industries, and because some species are zoonotic parasites which cause serious disease in humans. Research on the development of vaccines to prevent infection with cestode parasites has concentrated on the taeniid cestodes. Two strategies can be adopted for vaccine research: vaccines against infection in the definitive hosts and vaccines for use in the intermediate hosts. The number and accessibility of definitive hosts would favour these as potential targets for vaccines over intermediate hosts, however little success has been achieved in demonstrating immune-mediated resistance to infection in definitive hosts. In comparison, immunity in the intermediate hosts is a prominent feature of the host-parasite relationship in taeniid cestodes. This has favoured the development of vaccines against Taenia and Echinococcus species in their intermediate hosts. This paper reviews the progress which has been made in vaccination against cestode parasites and the prospects for practical application of these vaccines.
Lightowlers
M W
MW
Molecular Parasitology Laboratory, University of Melbourne, Werribee, Victoria, Australia. marshall@unimelb.edu.au
D000818:Animals; D000829:Animals, Domestic / Q000469:parasitology*; D000909:Antibodies, Helminth / Q000096:biosynthesis; D002589:Cestoda / Q000276:immunology*; D002590:Cestode Infections / Q000517:prevention & control* / Q000635:transmission; D006801:Humans; D014611:Vaccination; D014612:Vaccines / Q000276:immunology; D015047:Zoonoses
D000909:Antibodies, Helminth; D014612:Vaccines