title: Granulocyte-colony stimulating factor concentrations in a patient with plasma cell dyscrasia and clinical features of chronic neutrophilic leukaemia.
abstract: In order to study the pathogenesis of plasma cell dyscrasias with associated clinical features of chronic neutrophilic leukaemia, the concentration of granulocyte-colony stimulating factor (G-CSF) was measured in a patient, a 73 year old man, who underwent steroid pulse therapy. High G-CSF concentrations and leucocyte counts prior to treatment declined rapidly on administration of dexamethazone, but rose subsequently. G-CSF was not detected in primary cultures of bone marrow cells, but large amounts of interleukin-6 were found in the culture supernatant. These observations suggest that the neutrophilia observed in the patient represented a reactive response to G-CSF secreted from abnormal plasma cells or stromal cells rather than the existence of a genuine myeloproliferative disorder.
authors.affiliation: First Department of Internal Medicine, Kagawa Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nagai
authors.forename: S
authors.initials: S
authors.lastname: Oda
authors.forename: M
authors.initials: M
authors.lastname: Iwamoto
authors.forename: K
authors.initials: K
authors.lastname: Marumoto
authors.forename: M
authors.initials: M
authors.lastname: Fujita
authors.forename: J
authors.initials: J
authors.lastname: Takahara
mesh_terms: D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001853:Bone Marrow / Q000378:metabolism; D003907:Dexamethasone / Q000627:therapeutic use; D016179:Granulocyte Colony-Stimulating Factor / Q000032:analysis*; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis; D015467:Leukemia, Neutrophilic, Chronic / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D007958:Leukocyte Count; D008297:Male; D010265:Paraproteinemias / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D015850:Interleukin-6; D016179:Granulocyte Colony-Stimulating Factor; D003907:Dexamethasone