[Renal hypouricemia in juvenile diabetes mellitus].
OBJECTIVE
To evaluate renal tubular function in young insulin dependent diabetics.


METHODS
Plasma uric acid levels, renal urate excretion, uric acid tubular load and uric acid fractional excretion were compared between a group of young diabetics without microalbuminuria (n = 27), between 5.5 and 16.8 years of age, and a control group (n = 22).


RESULTS
The plasma uric acid levels was lower in the diabetic group than in the control group (2.9 +/- 0.7 vs 3.6 +/- 0.6 mg/dl). The renal excretion of urate was higher in the diabetic group than in the control group (17.6 +/- 4.8 vs 13.6 +/- 5.1 mg/kg/d). The uric acid tubular load was similar in both groups (2.5 +/- 1.0 vs 2.4 +/- 0.7 mg/min/1.73 m2). The uric acid fractional excretion was higher in the diabetic group than in the control group (20.9 +/- 11.9 vs 11.4 +/- 4.8%). No correlation between plasma uric acid level and renal urate excretion with insulin therapy (U/kg/d), metabolic control or the time of evolution was found.


CONCLUSIONS
These results suggest that, in young diabetics, there is a renal hypouricemia due to tubular defects.
Durá Travé
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T
Servicio de Pediatría, Hospital Universitario de San Juan, Facultad de Medicina, Universidad de Alicante, San Juan de Alicante.
Moya Benavent
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M
Casero Ariza
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J
D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000503:physiopathology / Q000652:urine; D003928:Diabetic Nephropathies / Q000097:blood* / Q000503:physiopathology / Q000652:urine; D005919:Glomerular Filtration Rate; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D014527:Uric Acid / Q000097:blood* / Q000652:urine
D001786:Blood Glucose; D003404:Creatinine; D006442:Glycated Hemoglobin; D014527:Uric Acid