Sodium lithium countertransport and blood pressure. Longitudinal findings.
A significant and positive association between red blood cell sodium lithium countertransport (Na-Li CT) and blood pressure has been found in numerous studies. However, the majority of the studies presented to date are cross-sectional in nature and limited information exists on the longitudinal association between Na-Li CT and blood pressure. The present study analyzes the longitudinal association between Na-Li CT and blood pressure in 124 men participants in the Olivetti Heart Study and normotensives at the baseline examination. The Na-Li CT measured at the 12 year follow-up examination was analyzed in regard to the blood pressure changes over time during the 12 year follow-up. Na-Li CT (measured at follow-up examination) was positively related to changes over time in systolic pressure (r = 0.16) and diastolic pressure (r = 0.07) and changes in body mass index (r = 0.18). When blood pressure changes over time were analyzed by tertiles of Na-Li CT, the highest tertile group exhibited on the average significantly higher increases in systolic blood pressure compared with participants of the lowest tertile of the Na-Li CT distribution. This difference remained statistically significant after adjusting for the changes in weight observed during the 12 years follow-up. These findings indicate that the Na-Li CT distribution is related to blood pressure changes over time. However, the usefulness of Na-Li CT as a predictor of incidence of hypertension remains to be established.
Trevisan
M
M
Department of Social and Preventive Medicine, State University of New York at Buffalo, New York 14214, USA.
Strazzullo
P
P
Cappuccio
F
F
Jossa
F
F
Iacone
R
R
Russo
I
I
Farinaro
E
E
D000328:Adult; D017920:Antiporters / Q000378:metabolism*; D001692:Biological Transport; D001794:Blood Pressure / Q000502:physiology*; D001835:Body Weight; D006801:Humans; D008094:Lithium / Q000378:metabolism*; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012964:Sodium / Q000378:metabolism*
D017920:Antiporters; C045885:sodium-lithium countertransporter; D008094:Lithium; D012964:Sodium