Frequency of partial D phenotypes in the south western region of France.
The aim of this study was to estimate the frequencies of partial D phenotypes among weak D (D14) blood samples. During one year, red blood cell samples with D14 phenotype were tested by the indirect antiglobulin test (IAT) using a panel of six anti-D monoclonal antibodies (Mabs). The panel of Mabs was selected for its capacity to define patterns of reactivity specific to the most frequent categories of partial D phenotypes. Among 475 D14 samples, 16 partial D phenotypes were identified (2 DIIIb, 3 DIVa, 4 DIVb et 7 DVI) corresponding to 3.36% of the D14 population. A strategy for systematic screening of partial D phenotypes is discussed in relation to the results of this study.
Roubinet
F
F
Laboratoire d'Immunohématologie, Etablissement de Transfusion Sanguine Pyrénées Garonne, Toulouse France.
Apoil
P A
PA
Blancher
A
A
D000911:Antibodies, Monoclonal; D016022:Case-Control Studies; D003298:Coombs Test; D004912:Erythrocytes / Q000276:immunology*; D005602:France; D006801:Humans; D007438:Introns; D010455:Peptides / Q000235:genetics*; D010641:Phenotype; D012204:Rh-Hr Blood-Group System / Q000235:genetics*; D012698:Serologic Tests / Q000379:methods*
D000911:Antibodies, Monoclonal; D010455:Peptides; D012204:Rh-Hr Blood-Group System; C026410:Rho(D) antigen