title: Kinetic analysis of recurrence and survival after potentially curative resection of nonsmall cell lung cancer.
abstract: BACKGROUND
  About two-thirds of the patients with nonsmall cell lung cancer (NSCLC) who undergo a potentially curative resection eventually suffer from recurrent disease. However, it has yet to be elucidated as to how survival after recurrence is influenced by different variables, including timing, type of recurrence, or other clinicopathological features. There have been few studies concentrating on the kinetics of growth of occult micrometastatic tumor cells that eventually manifest as tumor recurrence.
  
  
  METHODS
  We retrospectively reviewed the charts of 197 patients who developed recurrence after a potentially curative resection for NSCLC.
  
  
  RESULTS
  The median disease-free interval was a little over 1 year (395 days), as was the median postrecurrence survival-383 days. We created a model for the kinetics of recurrence by assuming that: (1) a tumor of 10(9) cells is the usual limit of detection, (2) patients generally die before the tumor reaches 10(12) cells, and (3) it takes 1 year for average lung cancer cells to show a 10-fold increase. The model indicated that as much as 10(9) tumor cells should have been present immediately after the operation. Alternatively, the residual tumor cells should have an accelerated growth after the surgery.
  
  
  CONCLUSIONS
  These models indicate the importance of developing a sensitive detection method for occult metastatic cells and to understand the tumor dormancy mechanism.
authors.affiliation: Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Mitsudomi
authors.forename: K
authors.initials: K
authors.lastname: Nishioka
authors.forename: R
authors.initials: R
authors.lastname: Maruyama
authors.forename: G
authors.initials: G
authors.lastname: Saitoh
authors.forename: M
authors.initials: M
authors.lastname: Hamatake
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuyama
authors.forename: H
authors.initials: H
authors.lastname: Yaita
authors.forename: T
authors.initials: T
authors.lastname: Ishida
authors.forename: K
authors.initials: K
authors.lastname: Sugimachi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007700:Kinetics; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018365:Neoplasm, Residual; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D016019:Survival Analysis