title: Ketoprofen lysine salt inhibits disuse-induced osteopenia in a new non-traumatic immobilization model in the rat.
abstract: Immobilization and the consequent unloading can cause osteopenia both in humans and in animals due to an increased bone resorption and a parallel reduction in bone formation. Non-steroidal anti-inflammatory drugs (NSAIDs), and in particular the aryl propionic acids, are described to prevent bone loss by inhibiting the cyclo-oxygenase activity. In this study we evaluated the role of a classical aryl propionic acid, ketoprofen lysine salt (KLS), in a new model of disuse-induced osteoporosis in the rat. Tail immobilization evoked a time-dependent bone loss in the caudal vertebral bodies, measured densitometrically as a reduction of bone mineral density (BMD) and content (BMC). KLS was administered once daily for 10 days by subcutaneous route at 0.5 mg kg-1, a dose lower than that effective to elicit an anti-inflammatory response. In these conditions, KLS completely abolished BMD and BMC decrease observed in the caudal vertebrae after 10-day immobilization, without affecting bone mass in normal (non-immobilized) rats. These results suggest that KLS can exert, besides to its anti-inflammatory effect, an anti-resorptive activity on bone that could be useful in the prevention of disuse-induced osteopenia.
authors.affiliation: DOMPE' S.p.A., L'Aquila, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Fiorentino
authors.forename: G
authors.initials: G
authors.lastname: Melillo
authors.forename: G
authors.initials: G
authors.lastname: Fedele
authors.forename: G
authors.initials: G
authors.lastname: Clavenna
authors.forename: C
authors.initials: C
authors.lastname: D'Agostino
authors.forename: E
authors.initials: E
authors.lastname: Mainetti
authors.forename: G F
authors.initials: GF
authors.lastname: Caselli
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D015519:Bone Density / Q000187:drug effects; D001851:Bone Diseases, Metabolic / Q000517:prevention & control*; D007103:Immobilization; D007660:Ketoprofen / Q000031:analogs & derivatives* / Q000494:pharmacology; D008239:Lysine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; C029946:ketoprofen lysine; D007660:Ketoprofen; D008239:Lysine