Transfer of planar and non-planar chlorobiphenyls, 4,4'-DDE and hexachlorobenzene from blood to milk and to suckling infants.
The transfer coefficients of tetra- and hexachlorobiphenyls (PCB-54; -80; -155; and -169), HCB and 4,4'-DDE between milk and blood were monitored for eight weeks in sheep previously administered with these compounds by intramuscular injection. Analyses were performed by high resolution gas chromatography. The milk/blood ratio on a fat basis was close to 1 for HCB, over 1 for 4,4'-DDE, PCB-155, and -169 and below 1 for PCB-54 and -80. It is speculated that the deviation from the ratio 1 results from the interactions of organochlorines with (lipo)proteins in blood and/or milk. In milk, the enrichment of 4,4'-DDE, PCB-155 and -169 was observed. The relative toxicity expressed by the toxic equivalent (on a fat basis) was approximately 2.5 times higher in milk than in blood.
Vrecl
M
M
Institute of Anatomy, Histology and Embryology, Veterinary Faculty, University of Ljubljans, Slovenia.
Jan
J
J
Pogacnik
A
A
Bavdek
S V
SV
D000818:Animals; D000833:Animals, Suckling; D002851:Chromatography, High Pressure Liquid; D003633:Dichlorodiphenyl Dichloroethylene / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D005260:Female; D006581:Hexachlorobenzene / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D007273:Injections, Intramuscular; D007774:Lactation; D008892:Milk / Q000737:chemistry / Q000378:metabolism*; D010573:Pesticide Residues / Q000032:analysis / Q000097:blood / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D012756:Sheep
D010573:Pesticide Residues; D003633:Dichlorodiphenyl Dichloroethylene; D006581:Hexachlorobenzene; D011078:Polychlorinated Biphenyls