title: Neurologic anomalies of Perrault syndrome.
abstract: We report on an 18-year-old man with neurosensory hearing loss and his sister with neurosensory hearing loss, ovarian dysgenesis, mental retardation, generalized ataxia of the trunk and limbs, and saccadic dysmetria. A CT scan showed cerebellar hypoplasia. The cardinal manifestations of Perrault syndrome in females are neurosensory hearing loss and ovarian dysgenesis. Other anomalies, including neurologic and skeletal, have been reported in other individuals with Perrault syndrome. We review the neurologic anomalies in previous patients with Perrault syndrome. Neurologic data are available on 14 of 21 girls; 7 of 14 had neurologic abnormalities. The high incidence of neurologic anomalies suggest that ataxia or mental retardation may not be just coincidental findings, but pleiotropic manifestations of Perrault syndrome.
authors.affiliation: Department of Pediatrics, Loyola University Medical Center, Maywood, Illinois 60153, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Gottschalk
authors.forename: S B
authors.initials: SB
authors.lastname: Coker
authors.forename: L A
authors.initials: LA
authors.lastname: Fox
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics / Q000503:physiopathology*; D000293:Adolescent; D005260:Female; D006319:Hearing Loss, Sensorineural; D006801:Humans; D008297:Male; D009460:Neurologic Examination; D013577:Syndrome