Serological profiles of hepatitis B carrier patients in Singapore with special reference to the frequency and significance of concurrent presence of HBsAg and anti-HBs.
Hepatitis B serological markers were investigated in 1,132 consecutive Singaporean HBV carriers. Hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (anti-HBs) were found concurrently in 234 carriers (234/1132 or 21%). Serum anti-HBs levels were more than 10 mIU/mL in 80 of these carriers (80/234 or 34%). There were no difference in HBeAg positive status, as well as HBV-DNA positive status in concurrent HBsAg/anti-HBs carriers compared to carriers without anti-HBs. Our results suggested that concurrent HBsAg and anti-HBs is a common serologic pattern in Singaporean HBV carriers.
Wang
Y M
YM
Department of Medicine National University of Singapore, Singapore.
Ng
W C
WC
Kang
J Y
JY
Yap
I
I
Seet
B L
BL
Teo
J
J
Smith
R
R
Guan
R
R
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002353:Carrier State / Q000453:epidemiology / Q000276:immunology*; D002648:Child; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D012698:Serologic Tests; D012846:Singapore
D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens