title: Slit-lamp needle revision of failed filtering blebs using mitomycin C.
abstract: OBJECTIVE
  The purpose of the study is to determine the efficacy and safety of Mitomycin C (MMC) augmented slit-lamp needle revision of failed filtration surgery.
  
  
  METHODS
  The authors retrospectively reviewed the charts of 62 patients (62 eyes) (age, 72 +/- 15 years) with failed filtration surgery who underwent needle revision using MMC. A mixture of 0.01 ml of MMC (0.4 mg/ml) and 0.02 ml of bupivacaine with epinephrine was injected subconjunctivally. Twenty to 30 minutes later, a 30-gauge needle was used to perforate the area of subconjunctival fibrosis and re-establish flow.
  
  
  RESULTS
  Overall, 118 needing procedures (mean, 1.9 +/- 1.4 revisions per eye; range, 1-7) were performed on 62 eyes (mean follow-up, 9.9 +/- 3.7 months; range, 4.5-20.1 months). Thirty-six patients (58.1%) were needled once and 26 patients (41.9%) underwent more than 1 needling procedure. Intraocular pressure decreased from 24.1 +/- 6.4 mmHg (range, 18-44) before surgery to 11.5 +/- 4.8 mmHg (range, 1-26) at last follow-up (P = 5.51 x 10(-21)). Antiglaucoma medications decreased from 1.6 +/- 1.0 to 0.3 +/- 0.6 (P = 3.8 x 10(-14)). Successful single-needling procedure was highly correlated with race (white) and past conventional glaucoma filtration surgery of more than 4 years. Complications included serous choroidal detachment (10 eyes), suprachoroidal hemorrhage (1 eye), bleb leak (5 eyes), iris blocking sclerostomy (2 eyes), hyphema (2 eyes), corneal abrasion (2 eyes), and hypotony (1 eye).
  
  
  CONCLUSIONS
  Mitomycin needle revision appears to be an extremely effective way to revive failed filtration surgery. The incidence of complications compares favorably to trabeculectomy with MMC.
authors.affiliation: University of Missouri-Kansas City School of Medicine, Department of Ophthalmology, Eye Foundation of Kansas City, Missouri 64108, USA.
authors.forename: P G
authors.initials: PG
authors.lastname: Mardelli
authors.forename: C M
authors.initials: CM
authors.lastname: Lederer
authors.forename: P L
authors.initials: PL
authors.lastname: Murray
authors.forename: S A
authors.initials: SA
authors.lastname: Pastor
authors.forename: K M
authors.initials: KM
authors.lastname: Hassanein
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017024:Chemotherapy, Adjuvant; D005260:Female; D018463:Filtering Surgery; D005500:Follow-Up Studies; D005901:Glaucoma / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D009339:Needles; D019384:Nucleic Acid Synthesis Inhibitors / Q000627:therapeutic use*; D011183:Postoperative Complications; D012086:Reoperation; D012189:Retrospective Studies
chemical_list: D019384:Nucleic Acid Synthesis Inhibitors; D016685:Mitomycin