title: Severe malaria in children in Papua New Guinea.
abstract: The clinical features of severe falciparum malaria and risk factors for mortality were studied in 489 children admitted with malaria to Madang Hospital, Papua New Guinea. The most common severe manifestations of malaria were severe anaemia (22%) and coma (16%). Children with severe anaemia were younger than those with coma (median age 2.2 vs. 3.7 years) and had been ill for longer before admission (median 7 vs. 4 days, respectively). Although the clinical features of coma in Madang children with malaria resembled closely those reported in African children, mortality was lower (8% vs. 17-25%, respectively). Overall, 17 (3.5%) children died, most within 12 h of admission. A high level of plasma lactate (> or = 5 mmol/l) was common (20%) and was the major predictor of death in multiple regression analysis. Raised plasma creatinine and decreased plasma bicarbonate were also independent predictors of mortality. Coma was not predictive of death, although a high proportion of children with profound coma died. Investigation of the causes of acidosis in children with malaria is a high research priority. In view of the short time interval between admission and death in many children, emphasis must be placed on the prevention or early recognition and treatment of acidosis in the district health clinic as well as the central hospital.
authors.affiliation: Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Allen
authors.forename: A
authors.initials: A
authors.lastname: O'Donnell
authors.forename: N D
authors.initials: ND
authors.lastname: Alexander
authors.forename: J B
authors.initials: JB
authors.lastname: Clegg
mesh_terms: D000740:Anemia / Q000469:parasitology; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003128:Coma / Q000469:parasitology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D016779:Malaria, Cerebral / Q000150:complications; D016778:Malaria, Falciparum / Q000097:blood / Q000150:complications* / Q000401:mortality; D008297:Male; D010219:Papua New Guinea / Q000453:epidemiology; D011446:Prospective Studies; D012131:Respiratory Insufficiency / Q000469:parasitology; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D015415:Biomarkers