title: Bridging to transplant. Equal extended survival for patients undergoing LVAD support when compared with long-term medical management.
abstract: Implantation of ventricular assist devices (VADs) to support patients awaiting cardiac transplant has become an effective means of assuring that these critically ill patients survive to transplant. The authors undertook a retrospective analysis of 115 consecutive patients listed for cardiac transplant from January 1992 through June 1995. A VAD was implanted in 19 of these patients. Survival was calculated by intent to treat from the time of transplant listing through heart transplant, if it occurred. The analysis demonstrates that the patients who underwent implantation of a VAD as bridge to transplant had survival times similar to those of patients with medical management. These survival statistics demonstrate the utility of VADs as an effective means to bridge critically ill patients until a suitable donor organ becomes available. In addition, as previous studies have suggested for acute results, earlier implementation and better patient selection may lead to improved long-term survival.
authors.affiliation: Division of Cardiothoracic Surgery, Pennsylvania State University-College of Medicine, University Hospital-Children's Hospital, Hershey, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Mehta
authors.forename: J P
authors.initials: JP
authors.lastname: Boehmer
authors.forename: W E
authors.initials: WE
authors.lastname: Pae
authors.forename: T X
authors.initials: TX
authors.lastname: Aufiero
authors.forename: D
authors.initials: D
authors.lastname: Davis
authors.forename: W S
authors.initials: WS
authors.lastname: Pierce
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006333:Heart Failure / Q000401:mortality / Q000601:surgery* / Q000628:therapy*; D016027:Heart Transplantation; D006353:Heart-Assist Devices; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications; D017202:Myocardial Ischemia / Q000401:mortality / Q000601:surgery; D018579:Patient Selection; D012189:Retrospective Studies; D012770:Shock, Cardiogenic / Q000209:etiology / Q000401:mortality / Q000601:surgery; D015996:Survival Rate; D013997:Time Factors