title: Clinical features, frequency and prognosis of Dukes' A colorectal carcinoma: a population-based investigation.
abstract: The main aim of this study was, through the data of a population-based Registry, to establish the incidence of Dukes' A lesions by year of registration and the main clinical features, and to assess cancer-specific survival. One hundred and eighteen Dukes' A colorectal tumours were diagnosed (in 117 patients) out of 1337 registered between 1984 and 1992 in the Health Care District of Modena, Northern Italy; 94 patients were treated with surgery and 23 with endoscopic polypectomy. The frequency of Dukes' A tumours ranged between 4.8% and 18% by year of registration. Dukes' A carcinomas were significantly more frequent in the distal colon. Only 5 patients (4%) died of their cancer, and in all patients the tumour was localised in the rectum. Carcinomas associated with a poor prognosis did not show any of the biological variables usually associated with an unfavourable outcome, but, our data suggest the possibility of incomplete removal of tumours at surgery.
authors.affiliation: University of Modena, Dipartimento di Scienze Morfologiche e Medico Legali, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Di Gregorio
authors.forename: R
authors.initials: R
authors.lastname: Fante
authors.forename: L
authors.initials: L
authors.lastname: Roncucci
authors.forename: M G
authors.initials: MG
authors.lastname: Tamassia
authors.forename: L
authors.initials: L
authors.lastname: Losi
authors.forename: P
authors.initials: P
authors.lastname: Benatti
authors.forename: M
authors.initials: M
authors.lastname: Pedroni
authors.forename: A
authors.initials: A
authors.lastname: Percesepe
authors.forename: S
authors.initials: S
authors.lastname: De Pietri
authors.forename: M
authors.initials: M
authors.lastname: Ponz de Leon
mesh_terms: D000368:Aged; D003110:Colonic Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D012004:Rectal Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D015996:Survival Rate