[Cytokines in surgical stress].
The systemic inflammatory response is seen in association with various clinical conditions. Tumor necrosis factor, or other cytokines play an important role in systemic inflammatory response syndrome (SIRS). A frequent complication of SIRS is the development of organ system dysfunction, such as ARDS, DIC, renal failure, shock, and multiple organ dysfunction. Inflammatory cytokines become a trigger for the production of phospholipase A2, eicosnoids, NO, endothelin-1, thrombomodulin, polymorphonuclear leukocyte, and adhesion molecules. These mediators cause complex pathophysiologic condition in SIRS. In this study, we discuss a role of cytokines in surgical stress, hemorrhagic shock, burns, and septic shock.
Endo
S
S
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
Inada
K
K
Sato
N
N
Kawamura
T
T
D002056:Burns / Q000503:physiopathology; D016207:Cytokines / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D012128:Respiratory Distress Syndrome / Q000503:physiopathology; D012771:Shock, Hemorrhagic / Q000503:physiopathology; D012772:Shock, Septic / Q000503:physiopathology; D013312:Stress, Physiological / Q000503:physiopathology*; D013514:Surgical Procedures, Operative; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha