title: Is vagal innervation to the atrioventricular node impaired after radiofrequency ablation of the slow atrioventricular nodal pathway?
abstract: To assess the potentially adverse effects of RF catheter ablation (RFCA) of the slow AV nodal pathway on the parasympathetic innervation to the AV node in patients with AV nodal reentrant tachycardia (AVNRT), AV nodal conduction was evaluated following vagal stimulation by means of a phenylephrine bolus injection (200 micrograms) before and after RFCA in ten patients (mean age, 37 +/- 14 years). Nine patients with AV reentrant tachycardia (AVRT) due to a left free wall accessory pathway served as a control group (mean age of 37 +/- 12 years). Whereas no prolongation of the AH interval was observed in the AVNRT group following the phenylephrine bolus during sinus rhythm, despite a significant slowing in sinus rate, phenylephrine administration in AVRT patients was associated with both slowing of the sinus rate and prolongation of the AH interval. Following successful RFCA, the same responses were observed. To delineate the indirect effect of heart rate on AV conduction in response to the phenylephrine bolus, the AH interval was also measured during fixed atrial pacing. A marked prolongation of the AH interval occurred in both groups following phenylephrine administration. This prolongation was biphasic in 50% of AVNRT patients before ablation, suggesting a predominant effect of vagal stimulation on the fast AV nodal pathway. RFCA was associated with disappearance of discontinuous AV conduction in all but one patient with AVNRT. Vagal stimulation caused the same amount of AH interval prolongation as before RFCA in both study groups. In conclusion, patients with AVNRT have a preserved modulation of AV nodal conduction in response to vagal stimulation during sinus rhythm. In addition, vagal stimulation seems to exert a predominant effect on the fast AV nodal pathway. RFCA of the slow AV nodal pathway in patients with AVNRT does not cause detectable damage to the vagal innervation to the AV node.
authors.affiliation: Department of Cardiological Sciences, St George's Hospital Medical School, London, United Kingdom.
authors.forename: J
authors.initials: J
authors.lastname: Kautzner
authors.forename: J
authors.initials: J
authors.lastname: Hartikainen
authors.forename: S
authors.initials: S
authors.lastname: Heald
authors.forename: M
authors.initials: M
authors.lastname: Malik
authors.forename: D
authors.initials: D
authors.lastname: Ward
authors.forename: E
authors.initials: E
authors.lastname: Rowland
mesh_terms: D000328:Adult; D016275:Atrial Function / Q000187:drug effects; D001283:Atrioventricular Node / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D002036:Bundle of His / Q000187:drug effects / Q000503:physiopathology; D002304:Cardiac Pacing, Artificial; D017115:Catheter Ablation; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D009431:Neural Conduction / Q000187:drug effects; D010275:Parasympathetic Nervous System / Q000503:physiopathology / Q000601:surgery; D010656:Phenylephrine / Q000008:administration & dosage / Q000494:pharmacology; D013566:Sympathomimetics / Q000008:administration & dosage / Q000494:pharmacology; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D014630:Vagus Nerve / Q000187:drug effects / Q000503:physiopathology*
chemical_list: D013566:Sympathomimetics; D010656:Phenylephrine