title: Proton magnetic resonance spectroscopy and intracranial tumours: clinical perspectives.
abstract: Proton magnetic resonance spectroscopy (1H-MRS) was applied to characterize intracranial tumours of different hystological types. Seventy patients with intracranial neoplasms were studied before receiving surgery, radiotherapy or chemotherapy. All tumours were characterized by reduced or absent N-acetylasparate and increased signal from choline-containing compounds. Distinctive patterns were observed only for primitive brain neoplasms; high-grade gliomas were differentiated from low-grade ones by higher levels of choline-containing compounds. The metabolic aspects of metastatic lesions were similar to high-grade gliomas. These results, together with the limitations of 1H-MRS and future applications are reviewed.
authors.affiliation: Neuroradiology Department, Scientific Institute S. Raffaele Hospital, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Falini
authors.forename: G
authors.initials: G
authors.lastname: Calabrese
authors.forename: D
authors.initials: D
authors.lastname: Origgi
authors.forename: S
authors.initials: S
authors.lastname: Lipari
authors.forename: F
authors.initials: F
authors.lastname: Triulzi
authors.forename: M
authors.initials: M
authors.lastname: Losa
authors.forename: G
authors.initials: G
authors.lastname: Scotti
mesh_terms: D000236:Adenoma / Q000378:metabolism*; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D001932:Brain Neoplasms / Q000378:metabolism* / Q000556:secondary*; D002794:Choline / Q000032:analysis; D003397:Craniopharyngioma / Q000378:metabolism; D003404:Creatinine / Q000032:analysis; D005910:Glioma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008223:Lymphoma / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008579:Meningioma / Q000378:metabolism*; D009362:Neoplasm Metastasis
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D003404:Creatinine; D002794:Choline