Hypoglycemic effect of water extract of the root of Pandanus odorus RIDL.
Hypoglycemic effect of water extract of the root of Pandanus odorus RIDL. (Thai name: Toei-hom, Pandanaceae) was examined in normal and streptozotocin-diabetic rats. In the hypoglycemic test without glucose load, an administration of the extract at doses of 0.125-0.5g/kg p.o. did not affect significantly the plasma glucose level in normal rats, whereas the extract significantly lowered the plasma glucose level at a dose of 0.5g/kg p.o. in diabetic rats. In oral glucose tolerance test, an administration of the extract at a dose of 0.5g/kg p.o. significantly lowered the plasma glucose level in normal rats. The extract at doses of 0.5 and 1.0g/kg p.o. also significantly lowered the plasma glucose level in diabetic rats. A reference drug, glibenclamide at a dose of 5 mg/kg p.o. showed a significant hypoglycemic effect in both normal and diabetic rats. Repeated administration of the extract at doses of 0.25 and 0.5 g/kg p.o. for 7d produced a significant hypoglycemic effect in diabetic rats. Glibenclamide (5 mg/kg p.o.) also caused a significant hypoglycemia in the diabetic rats. LD50 (95% confidence limit) after intraperitoneal injection was 1.87 (1.26-2.76)g/kg in male and female rats and 1.62 (1.18-2.24)g/kg in male and female mice, respectively. The LD50 after oral administration was over 8 g/kg in both sexes of rat and mice.
Peungvicha
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P
Department of Physiology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
Thirawarapan
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SS
Watanabe
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D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D005260:Female; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013785:Thailand
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts