[Selected immune response parameters in respiratory tract infections in mice--effect of combined treatment with tienamycin and coparvax].
The combined model of viral/bacterial infections has been used in the study. Tienamycin and Coparvax have been administered to infected mice. During the time of 3, 6, 9 and 14 days the hemagglutination inhibition reactions, migration inhibition of leukocytes, phagocytic activity and killing effect of the peritoneal exudate granulocytes have been made. The analysis of migration inhibition of leukocytes gave a statistically characteristic answer after using antigen of anatoxin compared to influenza antigen. In the group of animals which were treated with tienamycin and Coparvax a higher percentage of migration inhibition was observed than in the other group are substantial in the reaction of phagocytosis. Generally, a more beneficial influence of the combined treatment with tienamycin and coparvax has been observed.
Korczak
E
E
Zakładu Mikrobiologii Lekarskiej Instytutu Nauk Podstawowych WAM, Lodzi.
Ciebiada
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I
Denys
A
A
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D002464:Cell Migration Inhibition; D002465:Cell Movement / Q000187:drug effects; D003352:Corynebacterium; D004359:Drug Therapy, Combination; D006098:Granulocytes / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D010587:Phagocytosis / Q000187:drug effects; D012141:Respiratory Tract Infections / Q000188:drug therapy*; D013845:Thienamycins / Q000008:administration & dosage*; D014777:Virus Diseases / Q000188:drug therapy
D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines; C039725:Corynebacterium parvum vaccine; D013845:Thienamycins; C015537:thienamycin