title: Ocular response to lens care systems in adolescent soft contact lens wearers.
abstract: The purpose of this 3-year prospective study is to compare high school-aged subjects, randomized into wearing soft contact lenses and spectacles, in terms of ocular health, refractive status, and self-esteem. This report focuses on ocular response to the lens care systems used through the first 18 months of the investigation. Eighty-four subjects were randomly fitted with either CibaSoft Visitint or CibaSoft-Standard Visitint contact lenses. Three lens care systems, Ciba Vision AOSept Disinfection/Neutralization Solutions (AOSept), Opti-Free Rinsing, Disinfection, and Storage Solution (Opti-Free), and ReNu Multi-Purpose Solution (ReNu), were randomly prescribed to the subjects wearing contact lenses. Limbal congestion, conjunctival hyperemia, corneal staining with fluorescein, corneal edema, and corneal neovascularization were graded at dispensing and at 6-, 12-, and 18-month visits. There were no significant differences among the groups at baseline. At 6 months statistically significant difference (p = 0.0131, Kruksal-Wallis) was found for fluorescein staining of the cornea among the systems. At 12 months significant differences were found for corneal edema (p = 0.0404, Kruksal-Wallis) and neovascularization (p = 0.0315, Kruksal-Wallis) among the systems. At 18 months generalized conjunctival hyperemia was significantly different (p = 0.0234, Kruksal-Wallis) among the systems along with greater limbal congestion (p = 0.0015, Kruksal-Wallis) and neovascularization (p = 0.0238, Kruksal-Wallis). In conclusion, the cornea, limbal vessels and the conjunctiva respond differently to the lens care systems used in this study. Overall, patients using AOSept showed less corneal staining and inflammatory response than patients using ReNu and Opti-Free.
authors.affiliation: School of Optometry, Indiana University, Bloomington, USA.
authors.forename: P S
authors.initials: PS
authors.lastname: Soni
authors.forename: D G
authors.initials: DG
authors.lastname: Horner
authors.forename: J
authors.initials: J
authors.lastname: Ross
mesh_terms: D000293:Adolescent; D003228:Conjunctiva / Q000098:blood supply / Q000187:drug effects; D018639:Contact Lens Solutions / Q000009:adverse effects*; D003263:Contact Lenses, Hydrophilic; D003315:Cornea / Q000187:drug effects / Q000473:pathology; D015715:Corneal Edema / Q000139:chemically induced; D005123:Eye / Q000187:drug effects*; D005139:Eyeglasses; D019793:Fluorescein; D005452:Fluoresceins; D006801:Humans; D006940:Hyperemia / Q000139:chemically induced; D016850:Limbus Corneae / Q000098:blood supply / Q000187:drug effects; D009389:Neovascularization, Pathologic / Q000139:chemically induced; D011446:Prospective Studies; D013194:Staining and Labeling
chemical_list: D018639:Contact Lens Solutions; D005452:Fluoresceins; D019793:Fluorescein