Dietary trans-fatty acids and serum lipoproteins in humans.
Trans-fatty acids increase serum LDL-cholesterol and decrease HDL-cholesterol levels in humans when substituted for cis unsaturated fatty acids in the diet. Trans-fatty acids also increase lipoprotein (a) levels relative to other fatty acids. The effects on LDL and HDL may be mediated by the cholesteryl ester transfer protein.
Zock
P L
PL
Wageningen Agricultural University, The Netherlands.
Mensink
R P
RP
D002352:Carrier Proteins / Q000378:metabolism; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D018849:Controlled Clinical Trials as Topic; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D006023:Glycoproteins; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*
C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004042:Dietary Fats, Unsaturated; D006023:Glycoproteins; D017270:Lipoprotein(a)