title: Tolerance of nicotinamide and carbogen with radiation therapy for glioblastoma.
abstract: Nineteen patients with glioblastoma were treated with nicotinamide and carbogen and radiotherapy. Eight patients did not complete the protocol because of hepatic toxicity from phenytoin/nicotinamide drug interactions, persistent nausea or vomiting with nicotinamide, intolerance of the carbogen breathing apparatus, or other reason. In addition, early radiation neurotoxicity appeared increased.
authors.affiliation: British Columbia Cancer Agency, Vancouver Cancer Centre, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Pickles
authors.forename: P
authors.initials: P
authors.lastname: Graham
authors.forename: I
authors.initials: I
authors.lastname: Syndikus
authors.forename: D E
authors.initials: DE
authors.lastname: Rheaume
authors.forename: G G
authors.initials: GG
authors.lastname: Duncan
authors.forename: A
authors.initials: A
authors.lastname: Green
authors.forename: C
authors.initials: C
authors.lastname: Marlow
mesh_terms: D000280:Administration, Inhalation; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002245:Carbon Dioxide / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004361:Drug Tolerance; D005260:Female; D005909:Glioblastoma / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy*; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009536:Niacinamide / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D010100:Oxygen / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D051381:Rats; D016896:Treatment Outcome
chemical_list: D002245:Carbon Dioxide; D009536:Niacinamide; C011700:carbogen; D010100:Oxygen