Effect of intravenously applied canrenoate on ampullar endolymphatic potential.
The effect of canrenoate, an aldosterone antagonist, on the ampullar endolymphatic potential (AEP) was examined to assess a possible role for aldosterone in the ampulla. Intravenous administration of canrenoate increased the AEP amplitude in a dose-dependent manner, with a significant reduction of the AEP negative component induced by anoxia. Pretreatment with aldosterone attenuated the AEP change produced by canrenoate. The results suggest that aldosterone may be involved in the modulation of ampullar function.
Yura
K
K
Department of Otolaryngology, Kagawa Medical School, Japan.
Mori
N
N
Nario
K
K
Sakai
S
S
D000450:Aldosterone / Q000502:physiology; D000818:Animals; D002191:Canrenoic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D004710:Endolymph / Q000187:drug effects* / Q000502:physiology*; D006168:Guinea Pigs; D007262:Infusions, Intravenous; D000451:Mineralocorticoid Receptor Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D012665:Semicircular Canals / Q000502:physiology*
D000451:Mineralocorticoid Receptor Antagonists; D000450:Aldosterone; D002191:Canrenoic Acid