[Finasteride: a new drug for the treatment of male hirsutism and androgenetic alopecia?].
Finasteride is a drug which inhibits the transformation of testosterone into its active metabolite, dihydrotestosterone, in the target organs, i.e. the skin, the scalp, the liver and the prostate. In the pathogenic mechanism of hirsutism and androgenetic alopecia, and important role is presumably played by alterations of the mechanisms which transform testosterone into dihydrotestosterone. In some conditions an increase in dihydrotestosterone has been demonstrated, due to increased activity of the enzyme 5 alpha-reductase. The effect of finasteride develops above all at the level of type II 5 alpha-reductase. Recent studies have evaluated the effect of finasteride in patients of both sexes with hirsutism and androgenetic alopecia. In women with various forms of hyperandrogenism, the use of the drug at the doses commonly used for the treatment of benign prostatic hyperplasia seems to have induced a significant reduction in the degree of hirsutism. Furthermore, both in animals and men with alopecia, the drug seems to have led to an increase in the number and an improvement in the shape of the follicles in the anagen phase, and a simultaneous decrease of dehydrotestosterone at the level of the scalp. This study represents a review of the main results obtained over the last two years and reports the prospects which the use of finasteride may have in this context.
Spinucci
G
G
Dipartimento di Medicina interna e Gastroenterologia, Policlinico S. Orsola-Malpighi, Bologna.
Pasquali
R
R
D000505:Alopecia / Q000188:drug therapy*; D000728:Androgens / Q000493:pharmacokinetics; D013196:Dihydrotestosterone / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics*; D004791:Enzyme Inhibitors / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D018120:Finasteride / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006628:Hirsutism / Q000188:drug therapy*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011467:Prostate / Q000187:drug effects / Q000378:metabolism; D012535:Scalp / Q000187:drug effects / Q000378:metabolism; D012737:Sex Factors; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D013739:Testosterone / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics*
D000728:Androgens; D004791:Enzyme Inhibitors; D013196:Dihydrotestosterone; D013739:Testosterone; D018120:Finasteride