title: Oxidative hypothesis of atherogenesis.
abstract: The oxidative hypothesis of atherogenesis suggests that an important event in the development of atherosclerotic lesions is the oxidation of lipids contained in low-density lipoprotein (LDL). This hypothesis is supported by a number of in-vitro and in-vivo studies demonstrating the proatherogenic properties of oxidized LDL, the occurrence of oxidatively modified LDL in atherosclerotic lesions and the reduction of atherosclerotic events by antioxidants.
authors.affiliation: Institute of Biochemistry, University of Graz, Austria.
authors.forename: P
authors.initials: P
authors.lastname: Klatt
authors.forename: H
authors.initials: H
authors.lastname: Esterbauer
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000378:metabolism*
chemical_list: D008077:Lipoproteins, LDL