title: [Low prevalence of ant-hepatitis c virus antibodies in hepatocellular carcinoma in Senegal].
abstract: Senegal is a country with a high incidence of hepatocellular carcinoma (HCC). The role of the hepatitis B virus (HBV) in the genesis of HCC is well established. To evaluate the role of the hepatitis C virus (HCV) in the occurrence of HCC in Senegal, second-generation serologic tests were used to compare the prevalence of anti-HCV antibody in subjects with HCC and in controls without liver disease. A polymerase chain reaction assay was used to look for HCV RNA in sera from patients with HCC and anti-HCV antibody. HBV markers were assayed in all study subjects. Prevalences of anti-HCV antibody were 10.9% (7/64) in the HCC group and 5% (3/58) in the control group (NS). In the HCC group, anti-HCV antibody was found in 2.4% (1/42) of subjects positive for the hepatitis B antigen (HBsAg) versus 27.2% (6/22) of subjects negative for the HBsAg (p < 0.01). HCV RNA was detected in five of six anti-HCV-positive HCC patients. Prevalence of the HBsAg was 65.6% (42/64) in the HCC group versus 17.2% (10/58) in the control group (p < 10-8). Anti-HBV antibody was detected in 48.3% (28/58) of controls versus 6.3% (4/64) of HCC patients (p < 10-8). These data do not support a close epidemiologic association between the HCV and HCC in Senegal, where the HBV remains the main viral cause of HCC.
authors.affiliation: Service de Médecine Interne I, Hôpital A. Le Dantec, DAKAR, Sénégal.
authors.forename: M M
authors.initials: MM
authors.lastname: Ka
authors.forename: P
authors.initials: P
authors.lastname: Herve
authors.forename: B
authors.initials: B
authors.lastname: Leguenno
authors.forename: M F
authors.initials: MF
authors.lastname: Ndiaye
authors.forename: T M
authors.initials: TM
authors.lastname: Diop
authors.forename: B
authors.initials: B
authors.lastname: Diop
authors.forename: J M
authors.initials: JM
authors.lastname: Dangou
authors.forename: O
authors.initials: O
authors.lastname: Bao
authors.forename: C
authors.initials: C
authors.lastname: Brechot
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000097:blood*; D005260:Female; D016174:Hepacivirus / Q000235:genetics; D006514:Hepatitis B Surface Antigens / Q000097:blood; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012367:RNA, Viral / Q000032:analysis; D012675:Senegal; D016036:Seroepidemiologic Studies
chemical_list: D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies; D012367:RNA, Viral