title: Exercise causes blood glutathione oxidation in chronic obstructive pulmonary disease: prevention by O2 therapy.
abstract: The aim of the present study was to determine whether glutathione oxidation occurs in chronic obstructive pulmonary disease (COPD) patients who perform exercise and whether this could be prevented. Blood glutathione red-ox ratio [oxidized-to-reduced glutathione (GSSG/ GSH)] was significantly increased when patients performed exercise for a short period of time until exhaustion. Their resting blood GSSG/GSH was 0.039 +/- 0.008 (SD) (n = 5), whereas after exercise it increased to 0.085 +/- 0.019, P < 0.01. Glutathione oxidation associated with exercise was partially prevented by oxygen therapy (resting value: 0.037 +/- 0.014, n = 5; after exercise: 0.047 +/- 0.016, n = 5, P < 0.01). We conclude that light exercise causes an oxidation of glutathione in COPD patients, which can be partially prevented by oxygen therapy.
authors.affiliation: Departamento de Fisiología, Universidad de Valencia, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Viña
authors.forename: E
authors.initials: E
authors.lastname: Servera
authors.forename: M
authors.initials: M
authors.lastname: Asensi
authors.forename: J
authors.initials: J
authors.lastname: Sastre
authors.forename: F V
authors.initials: FV
authors.lastname: Pallardó
authors.forename: J A
authors.initials: JA
authors.lastname: Ferrero
authors.forename: J
authors.initials: J
authors.lastname: García-De-La-Asunción
authors.forename: V
authors.initials: V
authors.lastname: Antón
authors.forename: J
authors.initials: J
authors.lastname: Marín
mesh_terms: D002245:Carbon Dioxide / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005978:Glutathione / Q000097:blood*; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008173:Lung Diseases, Obstructive / Q000097:blood* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D010100:Oxygen / Q000097:blood; D010102:Oxygen Inhalation Therapy; D012129:Respiratory Function Tests
chemical_list: D002245:Carbon Dioxide; D019344:Lactic Acid; D005978:Glutathione; D010100:Oxygen