[Anti-idiotypic antibodies against antibodies to HBsAg and against antibodies to pre-S1 and pre-S2 fragments of HBV in patients with chronic HBs antigenemia].
Anti-idiotypic antibodies (anti-Id Ab) against antibodies to HBs, pre-S1 and pre-S2 antigenic domains of the HBV surface protein were searched for by enzyme-linked immunosorbent assay in single serum samples of 57 patients, chronic HBsAg carriers. IgG and/or IgM anti-Id Ab were detected in 15 patients (26%). IgG and / or IgM anti-[anti-HBs] anti-Id Ab were found in 8 serum samples (14%) and they appeared to occur more frequently in patients seropositive for HBeAg than in these seropositive for anti-HBe. IgG and / or IgM anti-[pre-S1] anti-Id Ab and IgG and / or IgM anti-[anti-pre-S2] anti-Id Ab were detected in 5 (9%) and 8 (14%) patients, respectively. Both these anti-Id Ab were found more frequently in patients seropositive for anti-HBe than in patients seropositive for HBeAg. Anti-[anti-pre-S2] anti-Id Ab occurred more frequently in patients with sever liver damage than in these with near normal liver or established cirrhosis.
Jagielski
P
P
Zakład Immunopatologii PZH w Warszawie.
Nitkiewicz
J
J
Swiderska
H
H
Kalinowska
B
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D002353:Carrier State / Q000276:immunology*; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006509:Hepatitis B / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012698:Serologic Tests
D000888:Antibodies, Anti-Idiotypic; D006514:Hepatitis B Surface Antigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M