DA1 and DA2 receptor regulation in the striatum of young and old rats after peripheral vestibular lesion.
Anatomical, lesion and functional studies have indicated that the mesostriatal dopaminergic (DAergic) system may serve as supravestibular center in posture and locomotion control. Nevertheless, no data are available on the involvement of DAergic systems during vestibular compensation. This study was designed for the analysis of DA1 and DA2 receptors in the striatum by means of quantitative receptor autoradiography 28 days after unilateral or bilateral lesion of the labyrinth in 3-month-old rats. Considering the severe decline of DA content and receptors in striatum and the difference in behavioral recovery after vestibular lesions in old age, we also analyzed 24-month-old, lesioned and unlesioned rats. In young rats, hemilabyrinthectomy caused a bilateral increase (20-30%) of DA1 receptors and a two-fold increase of DA2 receptors. In old-rats, we observed a similar modification of DA2 receptors, and a 50% increase in DA1 receptors. Bilabyrinthectomy did not modify DA1 receptor density and decreased DA2 receptor density in young animals, whereas it produced an increase in both DA1 and DA2 in old rats. This study provides evidence for the involvement of the DAergic system during vestibular compensation. Our results also indicate great biochemical plasticity of the remaining DA receptors in the striatum of old rats.
Giardino
L
L
Institute of Otolaryngology II, University of Milano, Italy. cefisnmo@mbox.vol.it
Zanni
M
M
Pignataro
O
O
D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D001345:Autoradiography; D001552:Benzazepines / Q000378:metabolism; D003342:Corpus Striatum / Q000254:growth & development / Q000378:metabolism*; D008124:Locomotion; D008297:Male; D009043:Motor Activity; D011187:Posture; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000096:biosynthesis*; D017448:Receptors, Dopamine D2 / Q000096:biosynthesis*; D013469:Sulpiride / Q000378:metabolism; D014316:Tritium; D014722:Vestibule, Labyrinth / Q000254:growth & development / Q000502:physiology*
D001552:Benzazepines; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D014316:Tritium; D013469:Sulpiride