Synthesis and antiinflammatory activity of certain thienopyrimidine derivatives.
Interaction of ethyl 2-amino-4,5,6, 7-tetrahydrobenzo[b]thiophene-3-carboxylate 1 with 2-thiophene carbonyl chloride 2 afforded ethyl 2-(2-thenoylamino)-4, 5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 3 which upon cyclization yielded 2-(2-thienyl)-5,6,7, 8-tetrahydrobenzo[b]-thieno[2,3-d]-4H-3, 1-oxazin-4-one 4 and 2(2-thienyl)-3-amino-5, 6,7,8-tetrahydrobenzo-[b]thieno[2,3-d]-3,4-dihydropyrimidin-4-one 6. Some of the prepared compounds were screened for their antiinflammatory activity, compound 7c and 9b showed significant activity.
el-Kerdawy
M M
MM
Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Egypt.
Yousif
M Y
MY
el-Emam
A A
AA
Moustafa
M A
MA
el-Sherbeny
M A
MA
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D005260:Female; D006099:Granuloma / Q000188:drug therapy / Q000473:pathology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011743:Pyrimidines