title: Sensing the heat: the application of isothermal titration calorimetry to thermodynamic studies of biomolecular interactions.
abstract: Biomolecular interactions can be defined by combining thermodynamic data on the energetic properties of the interaction with high-resolution structural data. The development of high sensitivity isothermal titration calorimetric equipment provides a dramatic advance in the gathering of thermodynamic data, and the interactions between biological macromolecules can now be described with unprecedented accuracy.
authors.affiliation: Department of Biochemistry, University College London, 91 Riding House Street, London W1P 8BT, UK.
authors.forename: J E
authors.initials: JE
authors.lastname: Ladbury
authors.forename: B Z
authors.initials: BZ
authors.lastname: Chowdhry
mesh_terms: D002151:Calorimetry; D018360:Crystallography, X-Ray; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D015398:Signal Transduction; D013816:Thermodynamics
chemical_list: D011506:Proteins