Effect of fish oil on indometacin-induced gastric lesions in rats.
The effect of fish oil in promoting the healing of indomethacin-induced gastric lesions was investigated in Wistar albino rats. After indomethacin treatment (30 mg/kg, s.c.), animals were given fish oil, olive oil, or normal diet for 48 h. The ulcer index was found to be decreased to 2.1 +/- 1.8 mm with fish oil, 13.7 +/1 5.4 mm with olive oil, and 14.6 +/- 2.4 mm with normal diet. Fish oil showed a potent healing-promoting effect on acute gastric erosions and ulcers induced by indomethacin and significantly enhanced the mucus content of the mucosa (p < 0.05).
Güzel
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Department of Physiology, Faculty of Medicine, University of Dicle, Diyarbakir, Turkey.
Ulak
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Sermet
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Ciçek
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Ulak
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M
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004032:Diet; D005395:Fish Oils / Q000627:therapeutic use*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007213:Indomethacin / Q000037:antagonists & inhibitors / Q000633:toxicity*; D008297:Male; D009093:Mucus / Q000378:metabolism; D000069463:Olive Oil; D010938:Plant Oils / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology
D000897:Anti-Ulcer Agents; D005395:Fish Oils; D000069463:Olive Oil; D010938:Plant Oils; D007213:Indomethacin