Alteration in IL-1 and arginase activity of tumor-associated macrophages: a role in the promotion of tumor growth.
The present investigations were undertaken to study whether the macrophages associated with Dalton's lymphoma (DLAM), a spontaneous T-cell lymphoma, are modulated for the secretion of tumor growth-promoting factors in ascites. The DL ascitic fluid (DLAF) and the culture supernatants of DLAM harvested from mid and late tumor-bearing stages, but not early tumor-bearing stage, enhanced the proliferation of DL cells in vitro. These observations indicate that DLAF contains certain DL growth-promoting substances and at least some of them are secreted by DLAM. The DLAM obtained from mid and late tumor-bearing stages showed enhanced IL-1 production and arginase activity, with a concomitant decline in the RNI production, which could be implicated in the DLAM-mediated promotion of tumor growth.
Parajuli
P
P
Department of Zoology, University of Delhi, India.
Singh
S M
SM
D000818:Animals; D001119:Arginase / Q000378:metabolism*; D001202:Ascitic Fluid / Q000378:metabolism / Q000473:pathology; D002455:Cell Division; D005260:Female; D007375:Interleukin-1 / Q000378:metabolism* / Q000494:pharmacology; D016399:Lymphoma, T-Cell / Q000378:metabolism* / Q000473:pathology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009363:Neoplasm Proteins / Q000378:metabolism*; D013047:Specific Pathogen-Free Organisms
D007375:Interleukin-1; D009363:Neoplasm Proteins; D001119:Arginase