[Plasma elastase alpha 1-proteinase inhibitor complex in children with bronchitis].
The objective of this study was to assess the diagnostic usefulness of plasma levels of polymorphonuclear neutrophil elastase-alpha 1-proteinase inhibitor complex (E-alpha 1PI) in children with bronchitis. One hundred and seven children aged 6 months to 15 years were studied: 36 with recurrent bronchitis (RB), 34 suffering from obstructive bronchitis (OB) and 37 disease free-control group (C). Systemic inflammatory response by ESR, total leukocyte (L), polymorphonuclear count (PMN), alpha 1-proteinase inhibitor (alpha 1PI) and C-reactive protein (CRP) in the blood was monitored simultaneously. A comparison of the levels of the investigated indicators in the acute phase (I) and in the stage without signs of diseases (II) was carried out. Upon examination 1, about 90% of the patients in both groups had mean levels of E-alpha 1PI significantly elevated (p < 0.001) over the control group. There was no significant correlation between the E-alpha 1PI concentration and other analyzed indicators of inflammation. These results show that E-alpha 1PI may serve as a sensitive indicator for granulocyte activation during the acute course of the disease, even in neutropenia.
Polańska
B
B
Katedra Propedeutyki Pediatrii i Klinika Immunologii Wieku Rozwojowego Akademii Medycznej we Wrocławiu.
Jankowski
A
A
D001991:Bronchitis / Q000097:blood*; D002097:C-Reactive Protein / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D019272:Leukocyte Elastase / Q000097:blood*; D008297:Male; D000515:alpha 1-Antitrypsin / Q000502:physiology*
D000515:alpha 1-Antitrypsin; D002097:C-Reactive Protein; D019272:Leukocyte Elastase