Therapeutic targeting of the p53 tumor suppressor gene.
The p53 tumor suppressor gene is a logical target for cancer therapy. Several therapeutic strategies can be envisioned based upon recent advances concerning structure and function of the p53 protein, its interaction with cellular and viral proteins and its roles in repairing DNA, regulating cell division and promoting apoptosis.
Beaudry
G A
GA
PharmaGenics Inc, 4 Pearl Court, Allendale, NJ 07401, USA. beaudry@pharmag.com
Bertelsen
A H
AH
Sherman
M I
MI
D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D015972:Gene Expression Regulation, Neoplastic; D016158:Genes, p53 / Q000187:drug effects*; D015316:Genetic Therapy; D005822:Genetic Vectors / Q000627:therapeutic use; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000276:immunology / Q000628:therapy*; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry / Q000502:physiology
D000970:Antineoplastic Agents; D016159:Tumor Suppressor Protein p53