The carcinogenic potency of carbon particles with and without PAH after repeated intratracheal administration in the rat.
The role of carcinogenic PAH in soot- and carbon black-related lung tumour induction in rats was investigated after intratracheal administration of carbon blacks (CB) and two types of diesel soot (DS), either as original or as toluene extracted particles. The total particle dose per animal was 15 mg subdivided into 16-17 weekly applications. There was one vehicle control and two groups were treated with a total dose of either 30 or 15 mg pure BaP as positive control. The main tumour results were: (a) original DS induced a higher tumour rate than extracted DS; (b) the carcinogenic potency of extracted CB probably depends on the size of the primary carbon particles and on the specific surface area of the particles; (c) extracted DS covered with 11 micrograms BaP per mg carbon particles caused a lower lung tumour rate than original DS containing only 0.9 ng BaP per mg, but a variety of other PAH and NO2-PAH; (d) a total dose of 15 mg pure BaP caused a lung tumour rate very similar to that of 30 mg extracted DS, 15 mg original DS or 15 mg Printex 90T CB extracted or covered with approximately 29.5 micrograms BaP per mg CB.
Dasenbrock
C
C
Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, Germany.
Peters
L
L
Creutzenberg
O
O
Heinrich
U
U
D000818:Animals; D001564:Benzo(a)pyrene; D002244:Carbon / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D005260:Female; D007442:Intubation, Intratracheal; D008168:Lung / Q000737:chemistry / Q000473:pathology; D008175:Lung Neoplasms / Q000139:chemically induced; D009929:Organ Size; D051381:Rats; D017208:Rats, Wistar; D015996:Survival Rate; D001335:Vehicle Emissions / Q000633:toxicity; D010130:p-Aminohippuric Acid / Q000737:chemistry / Q000633:toxicity*
D001335:Vehicle Emissions; D001564:Benzo(a)pyrene; D002244:Carbon; D010130:p-Aminohippuric Acid