Pharmacokinetics of ketoprofen in the donkey (Equus asinus).
The pharmacokinetic parameters of ketoprofen were determined in four donkeys after a single intravenous injection of a dose of 2.2 mg/kg body weight. The total body clearance (ClB) was 414.0 +/- 98.70 ml/h/kg (mean +/- SD), the volume of distribution at steady state (Vss) 263.10 +/- 55.43 ml/kg and the elimination half-life 1.30 +/- 0.75 h. These values were compared to those obtained in horses.
Oukessou
M
M
Institut Agronomique et Vétérinaire Hassan II, Rabat, Morocco.
Bouljihad
M
M
Van Gool
F
F
Alvinerie
M
M
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D018397:Equidae / Q000378:metabolism*; D005260:Female; D006736:Horses / Q000378:metabolism*; D007275:Injections, Intravenous / Q000662:veterinary; D007660:Ketoprofen / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen