title: Importance of metabolic function of the natural lung evaluated by prolonged exclusion of the pulmonary circulation.
abstract: It is generally considered that the natural lung metabolizes various vasoactive substances through the pulmonary circulation. However, the influences of bypassing or eliminating the pulmonary circulation have not been fully elucidated, especially for prolonged periods. In this study, we performed total cardiopulmonary bypass and exclusion of the pulmonary circulation for up to 336 hr in awake goats to clarify the importance of the metabolic function of the lung. In seven adult goats, biventricular bypass with a pulsatile ventricular assist system was first established. After 2 weeks, the biventricular bypass was converted to total cardiopulmonary bypass without anesthesia. Adequate gas exchange and perfusion support were achieved in all animals. However, the institution of total cardiopulmonary bypass led to marked decreases in the mean aortic pressure and systemic vascular resistance, and they remained low thereafter. The arterial levels of prostaglandin E2 and norepinephrine, which are inactivated naturally through the pulmonary circulation, increased remarkably. These results indicate that the natural lung plays an important role in controlling systemic circulation by metabolizing various vasoactive substances. Understanding the non respiratory function of the natural lung is of prime importance for advancement of lung and heart-lung support.
authors.affiliation: Department of Artificial Organs, Research Institute, Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Eya
authors.forename: E
authors.initials: E
authors.lastname: Tatsumi
authors.forename: Y
authors.initials: Y
authors.lastname: Taenaka
authors.forename: Y
authors.initials: Y
authors.lastname: Takewa
authors.forename: K
authors.initials: K
authors.lastname: Toda
authors.forename: Y
authors.initials: Y
authors.lastname: Wakisaka
authors.forename: T
authors.initials: T
authors.lastname: Nakatani
authors.forename: T
authors.initials: T
authors.lastname: Masuzawa
authors.forename: Y
authors.initials: Y
authors.lastname: Baba
authors.forename: K
authors.initials: K
authors.lastname: Miyazaki
authors.forename: T
authors.initials: T
authors.lastname: Nishimura
authors.forename: T
authors.initials: T
authors.lastname: Ohno
authors.forename: J M
authors.initials: JM
authors.lastname: Ahn
authors.forename: H
authors.initials: H
authors.lastname: Akagi
authors.forename: H
authors.initials: H
authors.lastname: Takano
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002315:Cardiopulmonary Bypass; D015232:Dinoprostone / Q000097:blood; D006041:Goats; D006353:Heart-Assist Devices; D008168:Lung / Q000378:metabolism*; D009638:Norepinephrine / Q000097:blood; D010107:Oxygenators, Membrane; D011652:Pulmonary Circulation / Q000502:physiology*; D013997:Time Factors; D014655:Vascular Resistance / Q000502:physiology
chemical_list: D015232:Dinoprostone; D009638:Norepinephrine