title: A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila.
abstract: The Drosophila MAP kinase DJNK is a homolog of the mammalian c-Jun amino-terminal kinase (JNK). Mutations in the DJNK gene correspond to the complementation group basket. DJNK is phosphorylated and activated by the Drosophila MAP kinase kinase HEP. Substrates of DJNK include the transcription factor DJun. DJNK participates in multiple physiological processes. Exposure to endotoxic lipopolysaccharide initiates an insect immune response and leads to DJNK activation. In addition, embryos lacking DJNK are defective in dorsal closure, a process in which the lateral epithelial cells migrate over the embryo and join at the dorsal midline. These data demonstrate that the DJNK signal transduction pathway mediates an immune response and morphogenesis in vivo.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605, USA.
authors.forename: H K
authors.initials: HK
authors.lastname: Sluss
authors.forename: Z
authors.initials: Z
authors.lastname: Han
authors.forename: T
authors.initials: T
authors.lastname: Barrett
authors.forename: D C
authors.initials: DC
authors.lastname: Goberdhan
authors.forename: C
authors.initials: C
authors.lastname: Wilson
authors.forename: R J
authors.initials: RJ
authors.lastname: Davis
authors.forename: Y T
authors.initials: YT
authors.lastname: Ip
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018076:DNA, Complementary; D004330:Drosophila / Q000196:embryology* / Q000276:immunology / Q000378:metabolism; D029721:Drosophila Proteins; D018507:Gene Expression Regulation, Developmental; D015971:Gene Expression Regulation, Enzymologic; D020929:Mitogen-Activated Protein Kinase Kinases / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D009024:Morphogenesis; D010641:Phenotype; D010766:Phosphorylation; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D013379:Substrate Specificity
chemical_list: D018076:DNA, Complementary; D029721:Drosophila Proteins; D011494:Protein Kinases; C117694:Hep protein, Drosophila; D020929:Mitogen-Activated Protein Kinase Kinases