title: Kurasoins A and B, new protein farnesyltransferase inhibitors produced by Paecilomyces sp. FO-3684. II. Structure elucidation and total synthesis.
abstract: The structures of new protein farnesyltransferase inhibitors, kurasoins A and B, were elucidated by NMR study. Kurasoins A and B are acyloin compounds having in common a 3-hydroxy-1-phenyl-2-butanone moiety, to which p-hydroxyphenyl and 3-indolyl moieties respectively, are connected at C-4. The structures were confirmed by total synthesis.
authors.affiliation: Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Uchida
authors.forename: K
authors.initials: K
authors.lastname: Shiomi
authors.forename: T
authors.initials: T
authors.lastname: Sunazuka
authors.forename: J
authors.initials: J
authors.lastname: Inokoshi
authors.forename: A
authors.initials: A
authors.lastname: Nishizawa
authors.forename: T
authors.initials: T
authors.lastname: Hirose
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Iwai
authors.forename: S
authors.initials: S
authors.lastname: Omura
mesh_terms: D019883:Alkyl and Aryl Transferases; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry*; D051231:Farnesyltranstransferase; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010143:Paecilomyces / Q000737:chemistry / Q000378:metabolism*; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry*; D014166:Transferases / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D007211:Indoles; D010636:Phenols; C102430:kurasoin A; C102431:kurasoin B; D014166:Transferases; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase