title: Isolation of two cytotoxic diterpenes from the fern Pteris multifida.
abstract: From aerial parts of the fern Pteris multifida Poir. (Polypodiaceae) two diterpenes, entkaurane-2 beta, 16 alpha-diol and ent-kaur-16-ene-2 beta, 15 alpha-diol, were isolated by repeated column chromatography using silica gel and silica gel impregnated with silver nitrate. The structures were confirmed by spectroscopic methods. Both compounds showed a moderate cytotoxicity to Ehrlich ascites tumour cells.
authors.affiliation: Department of Pharmaceutical Biology, University Centre for Pharmacy, Groningen Institute for Drug Studies (GIDS), University of Groningen, The Netherlands.
authors.forename: H J
authors.initials: HJ
authors.lastname: Woerdenbag
authors.forename: L R
authors.initials: LR
authors.lastname: Lutke
authors.forename: R
authors.initials: R
authors.lastname: Bos
authors.forename: J F
authors.initials: JF
authors.lastname: Stevens
authors.forename: R
authors.initials: R
authors.lastname: Hulst
authors.forename: W H
authors.initials: WH
authors.lastname: Kruizinga
authors.forename: Y P
authors.initials: YP
authors.lastname: Zhu
authors.forename: E T
authors.initials: ET
authors.lastname: Elema
authors.forename: H
authors.initials: H
authors.lastname: Hendriks
authors.forename: W
authors.initials: W
authors.lastname: van Uden
authors.forename: N
authors.initials: N
authors.lastname: Pras
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D002286:Carcinoma, Ehrlich Tumor; D002455:Cell Division; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity*; D008516:Medicine, Chinese Traditional; D051379:Mice; D015394:Molecular Structure; D010946:Plants, Medicinal; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes