Association between an angiotensinogen microsatellite marker in children and coronary events in their grandparents.
BACKGROUND
Recently we found that the deletion (D) allele of the insertion/deletion (I/D) polymorphism of the ACE gene in 404 children was associated with a history of coronary artery disease (CAD) in their grandparents. This led us to explore polymorphisms in other genes of the renin-angiotensin system in this same population.


RESULTS
We determined the genotypes for three microsatellite markers located near or in the angiotensinogen, angiotensin II (type-1) receptor, and renin genes in the children and related the allele frequencies to grandparental CAD. We found a significant association between the angiotensinogen marker in children and grandparental CAD (chi2 = 42.2, P = .00001) with these children having an excess of the 125-bp and 129-bp alleles (odds ratio, 2.5; 95% confidence interval, 1.7 to 3.7). Greatest grandparental risk was when their grandchildren had the 125-bp/125-bp, 129-bp/129-bp, or 125-bp/129-bp genotypes (odds ratio, 7.75; 95% confidence interval, 2.2 to 27). There was no association between the microsatellites at either the angiotensin II (type-1) receptor (P = .8) or renin (P = .2) genes in children and grandparental CAD and none between the angiotensinogen and ACE polymorphisms in relation to CAD family history.


CONCLUSIONS
This study identifies a significant association between an angiotensinogen marker in children and grandparental CAD. There was no association between the microsatellites at either the angiotensin II (type-1) receptor or renin genes and CAD in this population. We conclude that the angiotensinogen polymorphism as well as the ACE polymorphism may explain a part of the risk related to a family history of CAD.
Badenhop
R F
RF
Department of Cardiovascular Medicine, University of New South Wales/Prince Henry Hospital, Sydney, Australia.
Wang
X L
XL
Wilcken
D E
DE
D000293:Adolescent; D000483:Alleles; D000808:Angiotensinogen / Q000235:genetics*; D001483:Base Sequence; D002648:Child; D002675:Child, Preschool; D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008499:Medical Records; D018895:Microsatellite Repeats; D015335:Molecular Probes / Q000235:genetics; D008969:Molecular Sequence Data; D011945:Receptors, Angiotensin / Q000235:genetics; D012083:Renin / Q000235:genetics
D015335:Molecular Probes; D011945:Receptors, Angiotensin; D000808:Angiotensinogen; D012083:Renin