title: Suicidality, circadian activity rhythms and platelet serotonergic measures in patients with recurrent suicidal behaviour.
abstract: The circadian activity rhythm was assessed over a one-week period using a wrist-worn activity monitor in 59 patients with a history of recurrent suicide attempts. In 40 of these patients a second recording was made 6 months later. Platelet serotonin (5-HT) and monoamine oxidase-B activity (MAO) were measured. Suicidal ideation, borderline personality disorder and impulsiveness were associated with the absence of a clear 24-hour periodicity in motor activity. Depressive mood and hopelessness were associated with a less regular bed-in time and a lower daytime activity. Platelet 5-HT as well as MAO correlated negatively with the amplitude of the circadian activity rhythm. Our results support the suggested link between suicidality, altered circadian activity and serotonergic function.
authors.affiliation: Department of Psychiatry, University Hospital, Leiden.
authors.forename: R J
authors.initials: RJ
authors.lastname: Verkes
authors.forename: G A
authors.initials: GA
authors.lastname: Kerkhof
authors.forename: E
authors.initials: E
authors.lastname: Beld
authors.forename: M W
authors.initials: MW
authors.lastname: Hengeveld
authors.forename: G M
authors.initials: GM
authors.lastname: van Kempen
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000201:enzymology*; D001883:Borderline Personality Disorder / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D002940:Circadian Rhythm / Q000502:physiology*; D003866:Depressive Disorder / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007175:Impulsive Behavior / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D008297:Male; D008995:Monoamine Oxidase / Q000097:blood*; D009043:Motor Activity / Q000502:physiology*; D011985:Receptors, Serotonin / Q000502:physiology; D012701:Serotonin / Q000097:blood*; D013405:Suicide / Q000523:psychology*; D013406:Suicide, Attempted / Q000517:prevention & control / Q000523:psychology*; D000092864:Suicide Prevention
chemical_list: D011985:Receptors, Serotonin; D012701:Serotonin; D008995:Monoamine Oxidase