title: [Immuno-hemolytic transfusion reactions. IV. Analysis, risks and prevention].
abstract: The immunological risk of red blood cell transfusions now seems higher than the viral risk. According to studies, severe accidents due to blood incompatibility occur with a frequency estimated at 1/6000 to 1/29000; despite technical progress, the risk does not significantly diminish. The majority of accidents do not originate from laboratory or production stages but from defects in the application of clinical procedures. Preventive measures are based on (i) the elaboration of clinical guidelines, (ii) the compliance to strict rules in carrying out bedside ABO check, and (iii) the realization and interpretation of antibody screening tests. The implementation of quality assurance systems and of the epidemiological surveillance system, which define the basis of a prevention policy, leads to the expectation of an improvement of transfusion safety.
authors.affiliation: Centre National de Référence pour les Groupes Sanguins, INTS, Paris, France.
authors.forename: A M
authors.initials: AM
authors.lastname: Tissier
authors.forename: P Y
authors.initials: PY
authors.lastname: Le Pennec
authors.forename: E
authors.initials: E
authors.lastname: Hergon
authors.forename: P
authors.initials: P
authors.lastname: Rouger
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D017707:Erythrocyte Transfusion / Q000009:adverse effects*; D005260:Female; D006461:Hemolysis / Q000276:immunology*; D006801:Humans; D007154:Immune System Diseases / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011785:Quality Assurance, Health Care; D012307:Risk Factors; D017678:Sex Distribution