title: Comparison of morbidities in very low birthweight and normal birthweight infants during the first year of life in a developing country.
abstract: OBJECTIVE
  To compare the morbidities in the very low birthweight (VLBW; < 1500 g) and normal birthweight (NBW; > or = 2500 g) Malaysian infants during the first year of life.
  
  
  METHODS
  Prospective observational cohort study of consecutive surviving VLBW infants and randomly sampled NBW infants born in the Kuala Lumpur Maternity Hospital between 1 December 1989 and 31 December 1992. Infants were followed up regularly during the first year of life, after correction for prematurity.
  
  
  RESULTS
  Compared with NBW infants (n = 106), VLBW infants (n = 127) had significantly higher risk of failure to thrive (odds ratio [OR] = 8.0, 95% confidence intervals [CI]: 1.1 to 354.3), wheezing (OR = 3.7, 95% CI: 1.6 to 9.3), rehospitalization (OR = 2.3, 95% CI: 1.1 to 5.0), cerebral palsy (OR = 8.6, 95% CI: 2.0 to 77.6), neurosensory hearing loss (OR = 12.0, 95% CI: 1.7 to 513.6) and visual loss (7.9 vs 0%, P = 0.002). The mean mental developmental index (MDI) and mean psychomotor developmental index (PDI) at 1 year of age were significantly lower among VLBW infants (MDI 99 [SD = 28], PDI 89 [SD = 25]) than NBW infants (MDI 106 [SD = 18], PDI 101 [SD = 18]) (95% CI for difference between means being MDI: -14.1 to -1.7; and PDI: -17.6 to -6.0). Logistic regression analysis showed that among VLBW infants: (i) male sex, Malay ethnicity and bronchopulmonary dysplasia were significant risk factors associated with wheezing; (ii) longer duration of oxygen therapy during the neonatal period, seizures after the post-neonatal period and wheezing were significant risk factors associated with rehospitalization; and (iii) longer duration of oxygen therapy during the neonatal period was a significant risk factor associated with adverse neurodevelopmental outcome during the first year of life.
  
  
  CONCLUSIONS
  Compared with NBW infants, VLBW Malaysian infants had significantly higher risks of physical and neuro-developmental morbidities.
authors.affiliation: Department of Paediatrics, Faculty of Medicine, National University of Malaysia, Malaysia.
authors.forename: N Y
authors.initials: NY
authors.lastname: Boo
authors.forename: L C
authors.initials: LC
authors.lastname: Ong
authors.forename: M S
authors.initials: MS
authors.lastname: Lye
authors.forename: V
authors.initials: V
authors.lastname: Chandran
authors.forename: S L
authors.initials: SL
authors.lastname: Teoh
authors.forename: S
authors.initials: S
authors.lastname: Zamratol
authors.forename: M K
authors.initials: MK
authors.lastname: Nyein
authors.forename: L
authors.initials: L
authors.lastname: Allison
mesh_terms: D016022:Case-Control Studies; D002493:Central Nervous System Diseases / Q000209:etiology; D002657:Child Development / Q000502:physiology; D016001:Confidence Intervals; D003906:Developing Countries; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight / Q000254:growth & development*; D016015:Logistic Models; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D016017:Odds Ratio; D010359:Patient Readmission / Q000706:statistics & numerical data; D011446:Prospective Studies; D012120:Respiration Disorders / Q000209:etiology; D012307:Risk Factors; D014611:Vaccination / Q000706:statistics & numerical data