title: Reactions in leprosy: an epidemiological study of 386 patients in west Nepal.
abstract: This paper presents epidemiological data on reversal reaction (RR) and erythema nodosum leprosum reaction (ENL) from a retrospective study of 386 leprosy patients newly registered at Green Pastures Hospital, Pokhara, West Nepal. The average follow-up time was 21 months. The prevalence of RR at first examination was 28% (23-32), and the prevalence of ENL reaction was 5.7% (2.3-9.2). The overall incidence rates among the 335 patients that were available for follow-up were 8.7 (6.5-12)/100 person years at risk (PYAR) for RR and 3.2 (1.5-6.7)/100 PYAR for ENL. Relapse of RR was common (1.4/patient). In all, 52% of RR were complicated by new nerve function impairment, against 59% of ENL reactions. The finding of other investigators that most RRs occur during the first year of treatment was confirmed by this study. The most significant risk factor for RR was extent of clinical disease measured by a count of body areas with clinical signs of leprosy. The risk of developing a RR for patients with 'extensive disease' (3 or more out of 9 body areas involved) was 10 times that of patients with limited disease (Rate Ratio 10 (1.3-76), p = 0.026). The study indicated that the following categories of patients in Nepal are at high or increased risk of developing a RR: 1, borderline patients during their first year of MDT; and 2, patients with more extensive clinical disease as described above.
authors.affiliation: Green Pastures Hospital, Pokhara, Nepal.
authors.forename: W H
authors.initials: WH
authors.lastname: Van Brakel
authors.forename: I B
authors.initials: IB
authors.lastname: Khawas
authors.forename: S B
authors.initials: SB
authors.lastname: Lucas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003906:Developing Countries; D004893:Erythema Nodosum / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D015994:Incidence; D015440:Leprosy, Lepromatous / Q000150:complications / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009390:Nepal / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors