Inhibition of Trypanosoma cruzi and T. brucei NADH fumarate reductase by benznidazole and anthelmintic imidazole derivatives.
Turrens
J F
JF
Department of Biomedical Sciences, University of South Alabama, Mobile 36688-0002, USA.
Watts
B P
BP
Zhong
L
L
Docampo
R
R
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*; D009593:Nitroimidazoles / Q000494:pharmacology*; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D044925:Oxidoreductases Acting on CH-CH Group Donors; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014346:Trypanosoma brucei brucei / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development; D014349:Trypanosoma cruzi / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development
D001562:Benzimidazoles; D004791:Enzyme Inhibitors; D007093:Imidazoles; D009593:Nitroimidazoles; D014344:Trypanocidal Agents; D010088:Oxidoreductases; D044925:Oxidoreductases Acting on CH-CH Group Donors; C020155:fumarate reductase (NADH); C009999:benzonidazole