Roles of the JAK-STAT system in signal transduction via cytokine receptors.
JAK-STAT signaling pathways are known to play an essential role in the specific activation of interferon-inducible genes. Many cytokines interacting with the cytokine receptor superfamily also appear to activate these pathways. Recent evidence indicates that JAKs play an essential role(s) in cytokine receptor signaling, including both specific pathways linked to STATs and general pathways regulating cell growth and functions.
Watanabe
S
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Department of Molecular and Development Biology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan. sumiko@ims.u-tokyo.ac.jp
Arai
K i
Ki
D000818:Animals; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D016207:Cytokines / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D015368:Human T-lymphotropic virus 1; D006801:Humans; D007372:Interferons / Q000502:physiology; D007938:Leukemia / Q000235:genetics / Q000503:physiopathology; D008954:Models, Biological; D008961:Models, Structural; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D018121:Receptors, Cytokine / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction; D015534:Trans-Activators / Q000378:metabolism
D016207:Cytokines; D004268:DNA-Binding Proteins; D018121:Receptors, Cytokine; D015534:Trans-Activators; D007372:Interferons; D011505:Protein-Tyrosine Kinases