[Immunomorphologic markers in breast cancer].
Mammary carcinoma (MC) of various histological structure are studied immunomorphologically. Positive reaction with proliferative cells nuclear antigen (PCNA) oncoprotein cerbB-2, carcinoembryonic antigen (CEA), trophoblastic beta 1 globulin (TBG) and tissue protein ferritin (Fe) was observed in one third, and with cyprein in half of MC cases. Clear-cut dependence of immunomorphological parameters upon histologic structure and degree of malignancy was not established. An increase of PCNA content with the tumor size increase was observed. There is a tendency to more frequent observation of CEA, Fe, TBG in the presence of the lymph nodes metastases. Most unfavourable for the prognosis are combinations of positive reactions of CEA with TBG, CEA with OCNA, CEA with cerbB-2 as well as PCNA, cerbB-2, CEA.
Volchenko
N N
NN
Litvinova
L V
LV
Pugachev
K K
KK
Shimbireva
I B
IB
Kalashnikov
V V
VV
Frank
G A
GA
D000951:Antigens, Neoplasm / Q000032:analysis*; D001609:Beta-Globulins / Q000032:analysis; D014408:Biomarkers, Tumor / Q000276:immunology*; D001943:Breast Neoplasms / Q000276:immunology / Q000473:pathology*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D005293:Ferritins / Q000032:analysis; D006801:Humans; D009363:Neoplasm Proteins / Q000032:analysis*; D011257:Pregnancy Proteins / Q000032:analysis; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis
D000951:Antigens, Neoplasm; D001609:Beta-Globulins; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D005293:Ferritins; D009363:Neoplasm Proteins; D011257:Pregnancy Proteins; D018809:Proliferating Cell Nuclear Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases