title: [Clinical study on sulbactam/cefoperazone in urinary tract infections in elderly patients].
abstract: A clinical study on sulbactam/cefoperazone was performed and the following results were obtained. Sulbactam/cefoperazone was administered intravenously to 30 elderly patients with urinary tract infections. Those patients were treated with 1g of sulbactam/cefoperazone 2 times daily. 1. Clinical efficacies in 24 cases of complicated urinary tract infections were excellent in 8, moderate in 11 and poor in 5, with an overall efficacy rate of 79.2%. As to bacteriological responses, 20 of 25 strains identified in the complicated urinary tract infections were eradicated, with an eradication rate of 80%. 2. Clinical efficacies in two cases of acute uncomplicated pyelonephritis were excellent in 1 and moderate in 1, with an overall efficacy rate of 100%. Bacteriologically, two of the strains in the acute uncomplicated pyelonephritis was eradicated, with an eradication rate of 100%. 3. Safety evaluation was made in all 30 patients received sulbactam/cefoperazone. No adverse reactions were observed in any cases. As to laboratory test results, slight elevation of GPT was noted in 1 patient. In conclusion, sulbactam/cefoperazone is considered as a clinically useful antibiotics in the treatment of urinary tract infections with elderly patients.
authors.affiliation: Department of Urology, Omuta City General Hospital.
authors.forename: Y
authors.initials: Y
authors.lastname: Oyabu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000892:Anti-Infective Agents, Urinary / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D002438:Cefoperazone / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007682:Kidney Pelvis; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000188:drug therapy / Q000382:microbiology; D013407:Sulbactam / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000892:Anti-Infective Agents, Urinary; D004338:Drug Combinations; D002438:Cefoperazone; C057923:sulperazone; D013407:Sulbactam