title: A MAP kinase homologue from the human malaria parasite, Plasmodium falciparum.
abstract: Pfmap-1, a gene encoding a novel protein kinase, has been identified in the human malaria parasite Plasmodium falciparum, using the polymerase chain reaction with degenerate oligodeoxyribonucleotides designed to hybridise to conserved regions of cdc2-related kinases. Computer comparison with other protein kinases strongly suggests that the protein encoded by this gene is closely related to mitogen-activated protein (MAP) kinases, which play important roles in eukaryotic adaptative response and signal transduction. In addition to the conserved MAP kinase catalytic domain, Pfmap-1 contains a highly charged C-terminal extension that includes two sets of repeated amino acid motifs. Pfmap-1 is located on chromosome 14 of P.falciparum, and its mRNA has a size of 3.7 kb.
authors.affiliation: Unité INSERM 399, Faculté de Médecine de Marseille, France.
authors.forename: C M
authors.initials: CM
authors.lastname: Doerig
authors.forename: D
authors.initials: D
authors.lastname: Parzy
authors.forename: G
authors.initials: G
authors.lastname: Langsley
authors.forename: P
authors.initials: P
authors.lastname: Horrocks
authors.forename: R
authors.initials: R
authors.lastname: Carter
authors.forename: C D
authors.initials: CD
authors.lastname: Doerig
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000032:analysis / Q000235:genetics*; D002874:Chromosome Mapping; D018076:DNA, Complementary; D016054:DNA, Protozoan; D006801:Humans; D008969:Molecular Sequence Data; D010963:Plasmodium falciparum / Q000201:enzymology* / Q000235:genetics; D015800:Protozoan Proteins / Q000032:analysis / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
chemical_list: D018076:DNA, Complementary; D016054:DNA, Protozoan; D015800:Protozoan Proteins; D017871:Calcium-Calmodulin-Dependent Protein Kinases