[A tryptophan metabolic disorder in patients with kidney tumors].
Tryptophan metabolism was investigated in 108 patients with renal tumors and 449 controls. Histologically verified (96.2%) hypernephroid cancer and papillary pelvic cancer were recorded in 84.3 and 15.4% of patients, respectively. Endogenic carcinogen 3-oxy-antronilic acid (3-OAA) was found in the urine of 17.6% of patients vs. 5.6% of controls. The difference was statistically significant. 3-oxykinurenin was detected in 6.5% of patients. The difference with controls was insignificant. Tryptophan metabolism was specified in respect to tumor histology and sex.
Zhurkina
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D015095:3-Hydroxyanthranilic Acid / Q000378:metabolism; D000328:Adult; D000368:Aged; D002291:Carcinoma, Papillary / Q000652:urine*; D002292:Carcinoma, Renal Cell / Q000652:urine*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000652:urine*; D007737:Kynurenine / Q000031:analogs & derivatives / Q000652:urine; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics; D014364:Tryptophan / Q000652:urine*
D015095:3-Hydroxyanthranilic Acid; C005045:3-hydroxykynurenine; D007737:Kynurenine; D014364:Tryptophan