Potent and selective thrombin inhibitors incorporating the constrained arginine mimic l-3-piperidyl(N-guanidino)alanine at P1.
Levy
O E
OE
Corvas International Inc., San Diego, California 92121-1102, USA. odile_levy@corvas.com
Semple
J E
JE
Lim
M L
ML
Reiner
J
J
Rote
W E
WE
Dempsey
E
E
Richard
B M
BM
Zhang
E
E
Tulinsky
A
A
Ripka
W C
WC
Nutt
R F
RF
D000818:Animals; D000991:Antithrombins / Q000737:chemistry*; D001665:Binding Sites; D002851:Chromatography, High Pressure Liquid; D006146:Guanidines / Q000737:chemistry*; D006801:Humans; D010880:Piperidines / Q000737:chemistry*; D051381:Rats; D013237:Stereoisomerism; D013917:Thrombin / Q000737:chemistry
D000991:Antithrombins; D006146:Guanidines; D010880:Piperidines; C102318:alpha-((1-aminoiminopiperidin-3-yl)methyl)-N-(2-(3-benzylsulfonamido-2-oxopiperidin-1-yl)-1-oxoethyl)glycinal; D013917:Thrombin