[Efficacy and tolerability of paroxetine in the treatment of the depressive phase of bipolar disorders].
Eighty patients aged between 20-65 years and suffering from bipolar disease according to DSM IV criteria, were treated with paroxetine for os at the single dosage of 20-40 mg/die. At regular intervals psychometric reagents were administered for the evaluation and the variations in the bipolar disease. Tolerability was excellent and side-effects mild, with a tendency to regress after the second week of therapy. The clinical assessment and the psychometric findings both suggest that paroxetina has a useful action on the bipolar disease.
Ambrosio
L A
LA
Divisione di Psichiatria, Ospedali Riuniti, Cosenza.
Buccomino
D
D
Filippo
A
A
Morelli
A
A
Musacchio
R
R
Pupo
F
F
Romano
F E
FE
Marchese
G
G
Barrese
E
E
D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000008:administration & dosage / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales
D000928:Antidepressive Agents; D017374:Paroxetine