title: Genotoxicity of lynoral (ethinyloestradiol, an oestrogen) in mouse bone marrow cells, in vivo.
abstract: The genotoxic effect of Lynoral (ethinyloestradiol, an oestrogen) was studied using mouse bone marrow cells treated in vivo, employing a chromosomal aberration assay and micronucleus test. The dose and time-yield effects of the sex hormonal drug were investigated. Lynoral failed to induce significant genetic damage in the bone marrow erythrocytes of mice, regarding chromosomal aberrations and micronuclei.
authors.affiliation: Department of Zoology, Goa University, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Shyama
authors.forename: M A
authors.initials: MA
authors.lastname: Rahiman
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D004997:Ethinyl Estradiol / Q000633:toxicity*; D051379:Mice; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*
chemical_list: D009153:Mutagens; D004997:Ethinyl Estradiol