title: Induction chemotherapy followed by allogeneic bone marrow transplantation or aggressive consolidation chemotherapy in childhood acute myeloblastic leukemia. A prospective study from the French Society of Pediatric Hematology and Immunology (SHIP).
abstract: In the LAME89/91 protocol, children with acute myeloid leukemia (AML) who achieved complete remission (CR) after induction chemotherapy, were treated either with allogeneic bone marrow transplantation (BMT) if they had an HLA-compatible related donor or with chemotherapy including high-dose cytarabine. The objectives of this study were to describe the overall results of this strategy and to compare the two post-remission arms. Two hundred and thirty-one children were enrolled in the protocol. Induction chemotherapy consisted of a combination of cytarabine and mitoxantrone. A CR was achieved in 204 children (88%).
authors.affiliation: Service d'Hématologie Pédiatrique, Hôpital d'Enfants la Timone, Marseille, France.
authors.forename: G
authors.initials: G
authors.lastname: Michel
authors.forename: A
authors.initials: A
authors.lastname: Baruchel
authors.forename: M D
authors.initials: MD
authors.lastname: Tabone
authors.forename: B
authors.initials: B
authors.lastname: Nelken
authors.forename: T
authors.initials: T
authors.lastname: Leblanc
authors.forename: I
authors.initials: I
authors.lastname: Thuret
authors.forename: P
authors.initials: P
authors.lastname: Bordigoni
authors.forename: C
authors.initials: C
authors.lastname: Bergeron
authors.forename: H
authors.initials: H
authors.lastname: Esperou-Bourdeau
authors.forename: Y
authors.initials: Y
authors.lastname: Perel
authors.forename: J P
authors.initials: JP
authors.lastname: Vannier
authors.forename: L
authors.initials: L
authors.lastname: De Lumley
authors.forename: J P
authors.initials: JP
authors.lastname: Dommergues
authors.forename: J P
authors.initials: JP
authors.lastname: Lamagnère
authors.forename: G
authors.initials: G
authors.lastname: Couillaud
authors.forename: A
authors.initials: A
authors.lastname: Auvrignon
authors.forename: G
authors.initials: G
authors.lastname: Schaison
authors.forename: G
authors.initials: G
authors.lastname: Leverger
mesh_terms: D000208:Acute Disease; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007223:Infant; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000628:therapy*; D008297:Male; D011379:Prognosis; D011446:Prospective Studies