[Maternal-fetal transmission of the acquired immunodeficiency virus. Authors' experience].
The determination of human immunodeficiency virus (HIV) status of the newborn remains a major diagnostic problem as a routine test, which detects antibodies to HIV, is of limited value in evaluating newborns. However, the risk of infection for a baby whose mother is an HIV carrier is not yet clear.


OBJECTIVE
A prospective study to evaluate maternal transmission of HIV in our population. In order to provide a better estimate of the effect of some of the risk factors associated with HIV transmission we present a stratification of the transmission rate by these factors.


METHODS
Between January 1990 and December 1994 were examined a total of 10.949 pregnancies. To evaluate maternal HIV transmission to the fetus we considered a positive routine diagnostic test, which detects antibodies to HIV, of definite significance only at the age of 18 months or over.


RESULTS
Our prospective study shows an overall transmission rate in our population of 31.25%. Maternal disease stage, as reflected by CD4+ cell count, prematurity, mode of delivery (episiotomy) was correlated with HIV transmission.


CONCLUSIONS
Although some risk factors have been recognized, our understanding of the various modes of transmission is still limited. We conclude from our experience and previous studies that the risk of maternal to newborn transmission of HIV must be determined according to the specific characteristics of each parturient population.
Periti
E
E
Clinica Ostetrica e Ginecologica, Università degli Studi.
Innocenti
T A
TA
Fiscella
A
A
Branconi
F
F
D000163:Acquired Immunodeficiency Syndrome / Q000635:transmission* / Q000821:virology; D000328:Adult; D002353:Carrier State; D005260:Female; D015658:HIV Infections / Q000635:transmission* / Q000821:virology; D006679:HIV Seropositivity / Q000635:transmission* / Q000821:virology; D006801:Humans; D007231:Infant, Newborn; D007558:Italy / Q000453:epidemiology; D008403:Mass Screening; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000453:epidemiology / Q000821:virology*; D011446:Prospective Studies; D012307:Risk Factors