Spinocerebellar mossy fiber terminal topography in the NR2C/PKC gamma double mutant cerebellum.
The spatiotemporal expression patterns of the NR2C subunit of the NMDA receptor and PKC gamma isoform during cerebellar development suggests that both proteins are involved in the molecular mechanisms of synaptogenesis. However, the topographic distribution of WGA-HRP labeled spinocerebellar mossy fiber terminals in NR2C/PKC gamma double mutants (n = 4) appears similar to controls (n = 3). While the results do not rule out a role for NR2C receptor subunits and the PKC gamma isoform in cerebellar synaptogenesis, they indicate that neither is necessary for the formation or maintenance of normal spinocerebellar mossy fiber afferent maps.
Ji
Z
Z
Maryland Psychiatric Research Center University of Maryland Medical School, Baltimore 21228, USA.
Ebralidze
A
A
Tonegawa
S
S
Vogel
M W
MW
D000818:Animals; D001931:Brain Mapping; D002531:Cerebellum / Q000166:cytology*; D007527:Isoenzymes / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D016296:Mutagenesis / Q000502:physiology; D009434:Neural Pathways; D017729:Presynaptic Terminals / Q000737:chemistry / Q000201:enzymology; D011493:Protein Kinase C / Q000235:genetics*; D016194:Receptors, N-Methyl-D-Aspartate / Q000737:chemistry / Q000235:genetics*; D013116:Spinal Cord / Q000166:cytology*
D007527:Isoenzymes; D016194:Receptors, N-Methyl-D-Aspartate; C087857:protein kinase C gamma; D011493:Protein Kinase C