Absorption of phenol red and bromphenol blue as model drugs from the peritoneal cavity around the liver surface in rats.
The importance of the injection site on the pharmacokinetics of phenol red and bromphenol blue as model drugs after intraperitoneal administration into rat was examined. Their absorption rate from the peritoneal cavity was faster after intraperitoneal administration to the liver surface than that after intraperitoneal administration to the distal small intestine, as shown by the increase in maximum concentration and decrease in mean residence time in plasma. A similar tendency was observed in the biliary excretion pattern. The enhanced absorption rate was supported by the significantly smaller amount of both drugs remaining in the peritoneal cavity at 15 min after liver surface administration than that after small intestine administration. The liver concentration of the model drugs at 15 min after liver surface administration was 1.5-2.0 times that after small intestine administration. Accordingly, liver surface administration was shown to be effective with good absorption and efficient drug delivery to the liver.
Nishida
K
K
School of Pharmaceutical Sciences, Nagasaki University, Japan.
Amagishi
H
H
Sasaki
H
H
Nakamura
J
J
D000042:Absorption; D000818:Animals; D001659:Biliary Tract / Q000378:metabolism; D001978:Bromphenol Blue / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007202:Indicators and Reagents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007274:Injections, Intraperitoneal; D008099:Liver / Q000378:metabolism*; D008297:Male; D010529:Peritoneal Cavity; D010537:Peritoneum / Q000378:metabolism*; D010637:Phenolsulfonphthalein / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar
D007202:Indicators and Reagents; D001978:Bromphenol Blue; D010637:Phenolsulfonphthalein