title: Participation of non-major histocompatibility antigen complex gene in experimental autoimmune uveitis.
abstract: It is known that the susceptibility to experimental autoimmune uveitis (EAU) is controlled by both major histocompatibility antigen complex (MHC) and non-MHC genes. In this report, we studied the role of non-MHC genes in the induction of EAU. LEW, WKAH, (LEW x WKAH)F1, and (LEW x WKAH)F2 rats were examined to determine the incidence and severity of EAU induced by immunization with bovine S-antigen (S-Ag). We found that all the LEW rats developed severe EAU within 2 weeks after immunization, but no WKAH rats did. Most of the F1 rats developed mild inflammation in 3-4 weeks after immunization. A quarter of the F2 rats developed EAU within 2 weeks, half of them, in 3-6 weeks after immunization, and the others did not. These findings suggest that only one non-MHC gene controls the susceptibility to S-Ag-induced EAU in rats.
authors.affiliation: Department of Opthalmology, Hokkaido University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: S
authors.initials: S
authors.lastname: Hirose
authors.forename: Y
authors.initials: Y
authors.lastname: Sasamoto
authors.forename: S
authors.initials: S
authors.lastname: Kotake
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
mesh_terms: D000818:Animals; D019393:Arrestin / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology*; D002417:Cattle; D005260:Female; D020022:Genetic Predisposition to Disease; D006649:Histocompatibility Antigens / Q000235:genetics*; D007114:Immunization; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D014605:Uveitis / Q000235:genetics* / Q000276:immunology*
chemical_list: D019393:Arrestin; D001324:Autoantigens; D006649:Histocompatibility Antigens