[Pathophysiological basis of aminoglycoside-induced ototoxicity].
Recently proposed etiopathological mechanisms of aminoglycoside-induced toxicity were reviewed, including calcium, phosphatidylinositol, Na-K dependent ATPase, and neuronal sites of antibiotic action. Difficulties in evaluating the true clinical incidence of this aminoglycoside-induced ototoxicity and risk factors were analyzed. The relation between new dosing regimens (single daily dose) and ototoxicity are discussed.
Alamo
C
C
Departamento de Fisiología y Farmacología, Universidad de Alcalá de Henares, Madrid.
López-Munñoz
F
F
Cobeta
I
I
Rivera
T
T
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D006801:Humans; D009925:Organ of Corti / Q000187:drug effects; D010716:Phosphatidylinositols / Q000378:metabolism; D012307:Risk Factors; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D010716:Phosphatidylinositols; D000254:Sodium-Potassium-Exchanging ATPase; D002118:Calcium