title: The neuronal cytoskeleton: an insight for neurosurgeons.
abstract: The cytoskeleton is important in the structure and function of the neuron. Disruption of the cytoskeletal proteins occurs in a variety of forms of acute brain injury including cerebral ischaemia and diffuse anonal injury. The final common pathway mediating neuronal cell death involves loss of the integrity of the cytoskeleton and these disturbances may have a key role in the progression of events following acute brain injury. This review aims to provide an insight into the neuronal cytoskeleton in the normal state and in disorders encountered in neurosurgical practice.
authors.affiliation: Wellcome Surgical Institute, University of Glasgow, UK.
authors.forename: M O
authors.initials: MO
authors.lastname: Fitzpatrick
authors.forename: D
authors.initials: D
authors.lastname: Dewar
authors.forename: G M
authors.initials: GM
authors.lastname: Teasdale
authors.forename: D I
authors.initials: DI
authors.lastname: Graham
mesh_terms: D001369:Axons / Q000502:physiology; D001930:Brain Injuries / Q000503:physiopathology* / Q000601:surgery; D002545:Brain Ischemia / Q000503:physiopathology* / Q000601:surgery; D002470:Cell Survival / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000502:physiology*; D006801:Humans; D008868:Microtubule Proteins / Q000502:physiology; D009474:Neurons / Q000502:physiology; D011379:Prognosis
chemical_list: D003598:Cytoskeletal Proteins; D008868:Microtubule Proteins