title: Focal nodular hyperplasia of the liver: assessment of hemodynamic and angioarchitectural patterns with gadolinium chelate-enhanced 3D spoiled gradient-recalled MRI and maximum intensity projection reformatted images.
abstract: OBJECTIVE
  Our goal was to determine the relative merits of gadolinium chelate-enhanced 3D spoiled gradient-recalled (GRE) MRI versus maximum intensity projection (MIP) reformatted images in assessing the morphologic, hemodynamic, and angioarchitectural patterns of focal nodular hyperplasia (FNH) of the liver.
  
  
  METHODS
  Ten consecutive patients with 10 FNHs had prospectively gadolinium chelate-enhanced 3D spoiled GRE MRI (TR/TE/FA = 10.1/1.9/30) of the liver at 1.5 T. Gadolinium chelate-enhanced 3D spoiled GRE source images and MIP reformatted images were separately analyzed with respect to morphologic and hemodynamic features and angioarchitectural patterns by two independent readers.
  
  
  RESULTS
  Gadolinium chelate-enhanced 3D spoiled GRE source images and MIP reformatted images showed the most intense degrees of enhancement of FNH during the arterial phase of hepatic parenchymal enhancement in all cases. Gadolinium chelate-enhanced 3D spoiled GRE source images were superior to MIP reformatted images for the assessment of morphologic features of FNH (p < 0.02). MIP reformatted images were superior to the corresponding source images for showing the main branches of the hepatic artery, an arterial branch going to the FNH, and a small artery within the FNH radiating to peripheral areas (p < 0.05). There was excellent agreement between the two observers for analysis of the MIP reformatted images (p < 0.05).
  
  
  CONCLUSIONS
  The combination of gadolinium chelate-enhanced 3D spoiled GRE source images and MIP reformatted images allows the analysis of morphologic, hemodynamic, and angioarchitectural patterns of FNH of the liver. Further study and comparison with currently applied strategies will determine the value of these two techniques for diagnosing FNH of the liver.
authors.affiliation: Department of Radiology, Hôpital Foch, Suresnes, France.
authors.forename: P
authors.initials: P
authors.lastname: Soyer
authors.forename: A C
authors.initials: AC
authors.lastname: Dufresne
authors.forename: E
authors.initials: E
authors.lastname: Somveille
authors.forename: A
authors.initials: A
authors.lastname: Scherrer
mesh_terms: D000328:Adult; D000368:Aged; D002614:Chelating Agents; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D006439:Hemodynamics; D006571:Heterocyclic Compounds; D006801:Humans; D006965:Hyperplasia / Q000175:diagnosis / Q000503:physiopathology; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D008099:Liver / Q000098:blood supply* / Q000473:pathology* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D009942:Organometallic Compounds; D011446:Prospective Studies; D018709:Statistics, Nonparametric
chemical_list: D002614:Chelating Agents; D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; D005682:Gadolinium