title: 2-hydroxyestrone: the 'good' estrogen.
abstract: The issue of the role of 2-hydroxyestrone (2-OHE1) in breast cancer has been the subject of considerable controversy as to whether it is carcinogenic or anticarcinogenic. The expanding data base outlined below is most consistent with the conclusion that 2-OHE1 is anticarcinogenic. In every experimental model in which 2-hydroxylation was increased, protection against tumors was achieved. Correspondingly, when 2-hydroxylation was decreased, an increase in cancer risk was observed. Even more dramatically, in the case of laryngeal papillomas induction of 2-hydroxylation with indole-3-carbinol (I3C) has resulted in inhibition of tumor growth during the time that the patients continue to take 13C or vegetables rich in this compound.
authors.affiliation: Strang Cancer Research Laboratory, New York, New York 10021, USA.
authors.forename: H L
authors.initials: HL
authors.lastname: Bradlow
authors.forename: N T
authors.initials: NT
authors.lastname: Telang
authors.forename: D W
authors.initials: DW
authors.lastname: Sepkovic
authors.forename: M P
authors.initials: MP
authors.lastname: Osborne
mesh_terms: D016588:Anticarcinogenic Agents / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000517:prevention & control; D002393:Estrogens, Catechol / Q000378:metabolism*; D005260:Female; D006801:Humans; D006894:Hydroxyestrones / Q000378:metabolism*; D006900:Hydroxylation
chemical_list: D016588:Anticarcinogenic Agents; D002393:Estrogens, Catechol; D006894:Hydroxyestrones; C024980:2-hydroxyestrone