Telomerase: anti-cancer target or just a fascinating enzyme?
Telomerase activity is upregulated in most types of malignant tumor. Highly selective small molecule inhibitors will be needed to understand the biological basis for this observation and to determine if telomerase is a viable target for chemotherapy.
Hamilton
S E
SE
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA.
Corey
D R
DR
D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology*; D019098:Telomerase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015854:Up-Regulation
D004791:Enzyme Inhibitors; D019098:Telomerase