[LGL lymphoma].
We reported in this article two patients with large granular lymphocytic lymphoma (abbreviated as LGL lymphoma). One was the patient with LGL leukemia/lymphoma (patient 1) and other was the patient with NK-LGL lymphoma (patient 2). Because the gene of TCR delta was rearranged in the patient 1, the clonality of the LGL leukemia/lymphoma was confirmed. However, it is not determined yet whether the lineage of tumor cells is T cells or NK cells. The cytochemical features of the lymphoma cells of the patient 2 were studied. It was found that NK cell-derived lymphoma cells of the patient were positively stained with these two monoclonal antibodies that are reactive with T cell; one is anti-CD45RO (UCHL-1) and other is anti-CD3. Judging from the result, malignant NK-LGL cells in some patients are cytoplasmic CD3+ and UCHl-1+. It is emphasized that May-Grünwald-Giemsa stain of biopsied specimen of the lymphoma is required for making the diagnosis of LGL lymphoma.
Suzuki
K
K
Department of Clinical Hematology, Osaka University Medical School.
Tagawa
S
S
Koh
K
K
Hino
M
M
Yamane
T
T
Wakasa
K
K
Sasaki
M
M
Mizuki
M
M
Azenishi
Y
Y
Tanaka
H
H
Machii
T
T
Aozasa
K
K
Ohsawa
M
M
Sugano
Y
Y
Hara
J
J
Kawa
K
K
Tatsumi
N
N
D000328:Adult; D016694:Gene Rearrangement, delta-Chain T-Cell Antigen Receptor; D006801:Humans; D007244:Infectious Mononucleosis; D007694:Killer Cells, Natural; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000473:pathology