Determination of absolute configuration and biological activity of new immunosuppressants, mycestericins D, E, F and G.
Mycestericins D, E, F and G were isolated from the culture broth of Mycelia sterilia ATCC 20349 as potent immunosuppressants. Mycestericins F and G were identical with dihydromycestericins D and E, respectively. Their absolute configurations were determined by use of the modified MOSHER'S method and by comparison of the CD spectra of their benzoate derivatives with those of synthetic analogs. Mycestericins D, E, F and G suppressed the proliferation of lymphocytes in the mouse allogeneic mixed lymphocyte reaction.
Fujita
T
T
Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Hamamichi
N
N
Kiuchi
M
M
Matsuzaki
T
T
Kitao
Y
Y
Inoue
K
K
Hirose
R
R
Yoneta
M
M
Sasaki
S
S
Chiba
K
K
D000818:Animals; D002942:Circular Dichroism; D005229:Fatty Acids, Monounsaturated / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000737:chemistry* / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure
D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D007166:Immunosuppressive Agents; C102387:mycestericin F; C087465:mycestericin D