title: A multinational European survey on the in-vitro activity of rufloxacin and other comparative antibiotics on respiratory and urinary bacterial pathogens.
abstract: The antibacterial activity of rufloxacin was confirmed against a large number of respiratory and urinary tract pathogens collected in five European countries. In terms of both MIC90 values and percentages of susceptible isolates found, this new quinolone showed useful in-vitro activity against Mycoplasma catarrhalis, Haemophilus influenzae and Klebsiella pneumoniae, with a large proportion of Staphylococcus aureus also covered, while, as expected Streptococcus pneumoniae and Streptococcus pyogenes were not included in its antibacterial spectrum. Rufloxacin was comparable with the other antibiotics against these pathogens with the exception of streptococci. Against these microorganisms, beta-lactams were the most active agents. Against the urinary pathogens the in-vitro activity of rufloxacin is similar to that of norfloxacin although this latter drug is more active in terms of MIC90 values and in percentages of strains inhibited. In many cases more isolates were susceptible to the remaining comparator agents than to rufloxacin. However, there were no significant differences between the numbers of microorganisms inhibited by the various drugs and rufloxacin. The findings of this survey do not seem to modify the general picture which emerged in previous studies and further confirms its useful spectrum in different geographic settings.
authors.affiliation: Institute of Microbiology, University of Genoa, Italy.
authors.forename: G C
authors.initials: GC
authors.lastname: Schito
authors.forename: J F
authors.initials: JF
authors.lastname: Acar
authors.forename: A
authors.initials: A
authors.lastname: Bauernfeind
authors.forename: J
authors.initials: J
authors.lastname: Duval
authors.forename: R G
authors.initials: RG
authors.lastname: Finch
authors.forename: J
authors.initials: J
authors.lastname: Focht
authors.forename: G
authors.initials: G
authors.lastname: Nicoletti
authors.forename: I
authors.initials: I
authors.lastname: Phillips
authors.forename: G
authors.initials: G
authors.lastname: Pratts
authors.forename: F
authors.initials: F
authors.lastname: Soriano
authors.forename: B
authors.initials: B
authors.lastname: Wiedeman
authors.forename: R
authors.initials: R
authors.lastname: Wise
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D024841:Fluoroquinolones; D005602:France; D005858:Germany; D007558:Italy; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000494:pharmacology*; D012141:Respiratory Tract Infections / Q000382:microbiology*; D013030:Spain; D006113:United Kingdom; D014552:Urinary Tract Infections / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C060328:rufloxacin