[Cardiac surgery using cardiopulmonary bypass in a patient with sickle-cell trait].
The sickle-cell gene is most concentrated in West Central Africa, the northeast corner of Saudi Arabia and East Central India. Sickle cell trait is the heterozygous condition for Hb S gene. Thirty to fifty per cent of their hemoglobin is Hb S and the remainder is Hb A. The sickle-cell crisis is induced by hypoxia, hypercarbia, acidosis, low flow condition, and hypothermia, which leads to vasoocclusion. A 39-year-old black man from Burkina Faso located in West Africa with left ventricular rupture was admitted for operation using cardiopulmonary bypass (CPB). He had been diagnosed as sickle-cell trait. The Hb S concentration was 36.2 per cent before operation with hemoglobin electrophoresis. During CPB, the minimum blood temperature was 31 degrees C and an aortic cross-clamp was not done. Total CPB time was 1 hour 31 minutes. Use of vasodilator and hyperventilation was effective. No neurological sequelae were observed.
Ohashi
Y
Y
Department of Anesthesiology, National Cardiovascular Center, Suita.
Akamatsu
T
T
Hirata
T
T
Uchida
O
O
Kuro
M
M
D000328:Adult; D000354:Africa, Western / Q000208:ethnology; D006348:Cardiac Surgical Procedures / Q000379:methods; D002315:Cardiopulmonary Bypass; D006801:Humans; D008297:Male; D012805:Sickle Cell Trait / Q000150:complications* / Q000208:ethnology; D018658:Ventricular Septal Rupture / Q000601:surgery