An age-dependent novel hyperinnervation of circumvallate papillae by tyrosine hydroxylase-containing nerve fibers in NGF-overexpressing transgenic mice.
The density of protein gene product 9.5- and tyrosine hydroxylase-immunoreactive nerve fibers innervating circumvallate papillae of the tongue was substantially increased in transgenic mice that overexpressed nerve growth factor (NGF) when compared with age-matched controls. The fiber density was age-dependent. Only transgenic mice contained NGF-immunoreactive basal cells in the vicinity of taste buds, indicating that target-derived NGF induced novel hyperinnervation of the circumvallate papillae.
Takami
S
S
Department of Physiology, University of Kentucky College of Medicine, Lexington 40536-0084, USA.
Getchell
M L
ML
Albers
K M
KM
Getchell
T V
TV
D000375:Aging / Q000502:physiology*; D000818:Animals; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D008822:Mice, Transgenic; D009412:Nerve Fibers / Q000201:enzymology / Q000502:physiology*; D009414:Nerve Growth Factors / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D051381:Rats; D013650:Taste Buds / Q000502:physiology*; D013869:Thiolester Hydrolases / Q000096:biosynthesis; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*; D043222:Ubiquitin Thiolesterase
D009414:Nerve Growth Factors; D014446:Tyrosine 3-Monooxygenase; D013869:Thiolester Hydrolases; D043222:Ubiquitin Thiolesterase