title: The exon structure of the mouse Sc1 gene is very similar to the mouse Sparc gene.
abstract: Sc1 and Sparc are two extracellular proteins sharing similarity in their carboxyl terminus, with 63% identity over a 232-amino-acid region. We have cloned and mapped the genomic locus of mouse Sc1. The mouse Sc1 gene contains 11 exons spanning approximately 35 kb of DNA. The genomic structure (exon/intron boundaries) of Sc1 exons 6 to exon 11 is identical to those of the similar portion of the Sparc gene. This suggests that Sc1 and Sparc originated from a common ancestral gene. Using fluorescence in situ hybridization analysis, Sc1 was localized to band 5E4 of mouse chromosome 5.
authors.forename: P J
authors.initials: PJ
authors.lastname: McKinnon
authors.forename: M
authors.initials: M
authors.lastname: Kapsetaki
authors.forename: R F
authors.initials: RF
authors.lastname: Margolskee
mesh_terms: D020410:Activated-Leukocyte Cell Adhesion Molecule; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002875:Chromosomes; D003001:Cloning, Molecular; D019143:Evolution, Molecular; D005091:Exons / Q000235:genetics; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics*; D015676:Osteonectin / Q000235:genetics*; D017421:Sequence Analysis; D017385:Sequence Homology
chemical_list: D020410:Activated-Leukocyte Cell Adhesion Molecule; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D015676:Osteonectin