Epstein-Barr virus and human T-cell lymphomas.
Epstein-Barr virus has been classically associated with certain B-lymphocytic benign and malignant proliferations. However, using molecular biological techniques it becomes clear that EBV is also associated with several T-NHL in non-immunocompromised patients. The distribution of EBV-associated T-NHL seems to be site-restricted, i.e. in about 100% of the nasal T-NHL and in 20% of the lung and gastrointestinal lymphomas and rarely in primary cutaneous T-cell lymphomas. Moreover, the expression of the LMP1 protein seems to be associated with a poor prognosis. In this section the role of EBV in the pathogenesis of T-NHL will be discussed.
Meijer
C J
CJ
Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.
Jiwa
N M
NM
Dukers
D F
DF
Oudejans
J J
JJ
de Bruin
P C
PC
Walboomers
J M
JM
van den Brule
A J
AJ
D005770:Gastrointestinal Neoplasms / Q000821:virology; D006566:Herpesviridae Infections; D004854:Herpesvirus 4, Human / Q000472:pathogenicity; D006801:Humans; D008175:Lung Neoplasms / Q000821:virology; D016399:Lymphoma, T-Cell / Q000821:virology*; D016410:Lymphoma, T-Cell, Cutaneous / Q000821:virology; D009669:Nose Neoplasms / Q000821:virology; D009693:Nucleic Acid Hybridization / Q000379:methods; D014412:Tumor Virus Infections