title: Mutagenic activity of acrolein in S. typhimurium and E. coli.
abstract: Acrolein was tested for mutagenic activity in seven strains of Salmonella typhimurium and one strain of Escherichia coli using a preincubation assay procedure. Cytotoxicity was evident at dosing levels above 33 and 67 micrograms acrolein per plate in the absence and presence of S-9 activation, respectively. Evidence of mutagenic activity was seen at non-toxic dosing levels in S. typhimurium strains TA98 and TA100 and E. coli strain WP2 uvrA. Responses in TA98 and E. coli were marginal at best, but a firm positive mutagenic activity was noted in TA100 at 20 micrograms per plate without S-9 activation and at 67 micrograms per plate with S-9 activation. The results of this study demonstrate the mutagenicity of acrolein under highly controlled conditions.
authors.affiliation: Consultox Ltd., Damariscotta, ME 04543, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Parent
authors.forename: H E
authors.initials: HE
authors.lastname: Caravello
authors.forename: R H
authors.initials: RH
authors.lastname: San
mesh_terms: D000171:Acrolein / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
chemical_list: D009153:Mutagens; D000171:Acrolein