Fluoxetine augmentation of clozapine treatment in patients with schizophrenia.
OBJECTIVE
The authors examined the efficacy of fluoxetine augmentation of clozapine treatment response in schizophrenic outpatients who, despite adequate treatment with clozapine, continued to exhibit persistent positive or negative symptoms.


METHODS
Thirty-three patients completed on 8-week, double-blind, parallel-groups comparison of adjunctive fluoxetine and placebo.


RESULTS
There were no significant differences in positive, negative, depressive, or obsessive-compulsive symptoms between patients given adjunctive fluoxetine or placebo.


CONCLUSIONS
These results suggest that fluoxetine is not effective in augmenting clozapine treatment response.
Buchanan
R W
RW
Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21228, USA.
Kirkpatrick
B
B
Bryant
N
N
Ball
P
P
Breier
A
A
D000328:Adult; D000553:Ambulatory Care; D003024:Clozapine / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010919:Placebos; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D016896:Treatment Outcome
D010919:Placebos; D005473:Fluoxetine; D003024:Clozapine