title: Endothelin plasma levels in primary amenorrheic adolescents before and after estrogen treatment.
abstract: OBJECTIVE
  We evaluated the effect of estrogen administration on endothelin (ET) secretion in primary amenorrheic (PA) adolescent girls.
  
  
  METHODS
  Fifteen PA adolescents (ten hypergonadotropic, group A; five hypogonadotropic, group B) were treated with estrogen and progestogen tablets. A control group of ten healthy adolescents (group C) was included in the study. The ET 1-21, FSH, and LH plasma levels were tested before treatment (PrT) and immediately after the last estrogen tablet but before the progestogen administration (PoT).
  
  
  RESULTS
  A statistically significant difference (P < .01) in ET 1-21 plasma values was found between PrT (9.66 +/- 0.80 pmol/L) and PoT (7.56 +/- 0.89 pmol/L) levels in group A cases. A similar reduction (P < .05) was recorded between PrT (8.06 +/- 0.46 pmol/L) and PoT (5.59 +/- 0.53 pmol/L) ET 1-21 plasma levels in group B cases. Endothelin 1-21 plasma PrT values were higher in both group A and B cases in comparison with controls (6.66 +/- 0.44 pmol/L; P < .01, P < .1, respectively).
  
  
  CONCLUSIONS
  Estrogens administered to PA adolescents reduce ET 1-21 plasma levels in both hyper-and hypogonadotropism.
authors.affiliation: First Department of Obstetrics and Gynecology, Alexandra Hospital, University of Athens, Greece.
authors.forename: G C
authors.initials: GC
authors.lastname: Creatsas
authors.forename: A B
authors.initials: AB
authors.lastname: Malamitsi-Puchner
authors.forename: E A
authors.initials: EA
authors.lastname: Hassan
authors.forename: E B
authors.initials: EB
authors.lastname: Economou
authors.forename: D I
authors.initials: DI
authors.lastname: Aravantinos
mesh_terms: D000293:Adolescent; D000568:Amenorrhea / Q000097:blood* / Q000188:drug therapy; D015331:Cohort Studies; D019332:Endothelin-1 / Q000097:blood* / Q000187:drug effects / Q000378:metabolism; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000378:metabolism; D006065:Gonadotropins, Pituitary / Q000097:blood* / Q000378:metabolism; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood / Q000187:drug effects / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D019332:Endothelin-1; D004966:Estrogens, Conjugated (USP); D006065:Gonadotropins, Pituitary; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone