title: Premature luteinization during controlled ovarian hyperstimulation for in vitro fertilization-embryo transfer has no impact on pregnancy outcome.
abstract: OBJECTIVE
  To determine if elevated serum P concentration on the day of hCG administration or P area under the curve (AUC) impacts on pregnancy rates (PRs) in IVF-ET cycles.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  One hundred thirty-three couples underwent IVF-ET using luteal GnRH-agonist suppression followed by hyperstimulation with gonadotropins. Patient cycles were controlled for female age, ovarian reserve, male factor with intracytoplasmic sperm injection (ICSI), endometrial thickness and pattern, number of embryos, and number of high-quality embryos transferred, and cell stage at transfer. Pregnancy was defined as an ongoing pregnancy > 20 weeks.
  
  
  RESULTS
  Patients and cycle parameters did not differ significantly based on the control parameters. Similar numbers of severe male factors treated by ICSI were in each group with similar PRs. Pregnancy rates and implantation rates did not differ based on P levels < or = 0.9, < or = 1.1, and < or = 1.4 ng/mL (conversion factor to SI unit, 3.18). Serum P concentrations per total eggs retrieved or per mature egg retrieved did not influence pregnancy outcome. Efficiency curves for serum P levels and P AUC did not demonstrate any differences in PR. At very high serum P (P > 2.0 ng/mL) samples size limits the ability of these data to rule out a negative effect.
  
  
  CONCLUSIONS
  Serum P levels (and P AUC) commonly encountered during cycles of IVF-ET have no impact on pregnancy outcome.
authors.affiliation: Department of Obstetrics and Gynecology, Bethesda Hospital, USA.
authors.forename: G E
authors.initials: GE
authors.lastname: Hofmann
authors.forename: J
authors.initials: J
authors.lastname: Khoury
authors.forename: C A
authors.initials: CA
authors.lastname: Johnson
authors.forename: J
authors.initials: J
authors.lastname: Thie
authors.forename: R T
authors.initials: RT
authors.lastname: Scott
mesh_terms: D000328:Adult; D019540:Area Under Curve; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D003338:Corpus Luteum / Q000502:physiology*; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008297:Male; D010053:Ovary / Q000187:drug effects / Q000503:physiopathology*; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000097:blood; D012189:Retrospective Studies
chemical_list: D006063:Chorionic Gonadotropin; D011374:Progesterone