Synthesis and blood compatibility evaluation of segmented polyurethanes based on cholesterol and phosphatidylcholine analogous moieties.
New segmented polyurethanes based on cholesterol and phosphatidylcholine analogous moieties were synthesized. The soft segments used in this study were the poly(butadiene), poly(isoprene) or hydrogenated poly(isoprene) glycols; the hard segments of these segmented polyurethanes were composed of 4,4'-methylenediphenyl diisocyanate, 2-[bis(2-hydroxyethyl)methylammonio]ethyl 5-cholesten-3 beta-yl phosphate and 1,4-butanediol. The blood compatibilities of synthesized segmented polyurethanes were evaluated by platelet-rich plasma contact studies and scanning electron microscopy observation using glass as the reference. The results show that the blood compatibilities of the synthesized segmented polyurethanes have great difference between the glass contact side and air exposed side for the same cast films. Generally, the hydrogenated poly(isoprene)-based segmented polyurethane is the best surface in terms of platelet adhesion, and the morphology of adhered platelets undergoes the lowest degree of variation among the segmented polyurethanes investigated in this study.
Li
Y J
YJ
Department of Bio-applied Chemistry, Faculty of Engineering, Osaka City University, Japan.
Yokawa
T
T
Matthews
K H
KH
Chen
T M
TM
Wang
Y F
YF
Kodama
M
M
Nakaya
T
T
D001672:Biocompatible Materials; D002784:Cholesterol; D015195:Drug Design; D005898:Glass; D006801:Humans; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D010713:Phosphatidylcholines; D010973:Platelet Adhesiveness; D011140:Polyurethanes / Q000138:chemical synthesis* / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013499:Surface Properties
D001672:Biocompatible Materials; D010713:Phosphatidylcholines; D011140:Polyurethanes; D002784:Cholesterol