title: Cosolvent solubilization and formulation of an aqueous injection of ketoprofen.
abstract: Ketoprofen (1) an analgesic, antipyretic and anti-inflammatory agent, is practically insoluble in water. An increase in the aqueous solubility of 1 was attempted by various cosolvents. The solubility increased up to 8556 times (maximum) in case of ethanol while it was 33 times (minimum) in case of glycerol. Using selected cosolvents and hydrotropes, aqueous injections of 1 were formulated.
authors.affiliation: Department of Pharmaceutical Sciences, University of Saugar, India.
authors.forename: A K
authors.initials: AK
authors.lastname: Singhai
authors.forename: S
authors.initials: S
authors.lastname: Jain
authors.forename: N K
authors.initials: NK
authors.lastname: Jain
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry*; D004339:Drug Compounding; D005612:Freeze Drying; D006863:Hydrogen-Ion Concentration; D007267:Injections; D007660:Ketoprofen / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility; D012997:Solvents
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D012997:Solvents; D007660:Ketoprofen