A model of the immune network with B-T cell co-operation. I--Prototypical structures and dynamics.
Hitherto, "second generation" network models of the immune system have all been restricted to B-lymphocytes and the Ig molecules they produce. These models have not so far been able to provide a convincing mechanism for the distinction between a "Central Immune System" (CIS) composed of a connected network of lymphocyte clones which couple with "self" antigens in a tolerant mode, and a "Peripheral Immune System" (PIS) composed of clones with little or no supra-clonal organization and which produce classical immune responses when interacting with "non-self" antigens. Here, we present a new network model which explicitly incorporates B-T cell co-operation. In this model, B-cell activation is dependent on T-cell help, and activated T-cells are down-regulated by engagement of their TCRs by soluble Ig. We discuss the underlying biology on which we base the system of ordinary differential equations which defines the present network model. We then illustrate some basic features of the model by examining several prototypical situations with a small number of clones. Depending on the idiotypic connectivity structure, the model exhibits two distinct modes of coupling with antigens: an "immune response" mode in which T- and B-cell clones grow exponentially; and a "tolerant" mode in which T-cell clones are controlled by inclusion of all TCRs in the repertoire of an idiotypic B-cell network. Finally, we discuss the simplifying assumptions of the present model and argue that its range of validity is indeed the region of the state-space of the system where the discrimination between the CIS and the PIS take place.
Carneiro
J
J
Unité d'Immubiologie, CNRS URA 1961, Institut Pasteur, Paris, France, carneiro@pasteur.fr
Coutinho
A
A
Faro
J
J
Stewart
J
J
D001402:B-Lymphocytes / Q000276:immunology*; D019295:Computational Biology; D006801:Humans; D008211:Lymphocyte Cooperation; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000276:immunology*