Antidepressant-induced hypomania in obsessive-compulsive disorder.
Out of ten consecutive patients with DSM-III-R obsessive-compulsive disorder without any previous history of bipolarity, three patients showed antidepressant-induced hypomania (clomipramine, one patient; fluvoxamine, two patients) within the first 5 to 8 weeks of the drug treatment. These data support the previous results on a strong association between obsessive-compulsive disorder and bipolar affective illness.
Rihmer
Z
Z
Department of Psychiatry No. XIII., National Institute for Psychiatry and Neurology, Budapest, Hungary.
Barsi
J
J
Belsõ
N
N
Pestality
P
P
György
S
S
D000293:Adolescent; D000328:Adult; D000341:Affective Disorders, Psychotic / Q000139:chemically induced*; D000928:Antidepressive Agents / Q000009:adverse effects*; D002997:Clomipramine / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D016666:Fluvoxamine / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*
D000928:Antidepressive Agents; D002997:Clomipramine; D016666:Fluvoxamine; D017367:Selective Serotonin Reuptake Inhibitors