title: Intravenous sedation prior to peribulbar anaesthesia for cataract surgery in elderly patients.
abstract: OBJECTIVE
  To investigate if pre-block iv sedation using midazolam, alfentanil, or a midazolam-alfentanil combination minimizes pain, reduces pain recall, and attenuates haemodynamic responses to peribulbar block; and to determine other factors influencing oxygen saturation (SpO2) following iv sedation.
  
  
  METHODS
  In a randomized, double-blind, placebo-controlled study, 120 patients, mean age 73 yr, having cataract surgery with peribular anaesthesia, were randomized to receive either normal saline, 1 mg midazolam, 500 micrograms alfentanil, or 0.5 mg midazolam plus 250 micrograms alfentanil. Blood pressure (BP), heart rate (HR) and pulse oximetry readings were recorded before injection of the study drugs, immediately after completion of the peribulbar block, and 10 min after the block. Pain from the anaesthetic block was assessed immediately after the block and after surgery using a visual analog scale, and recall of pain was assessed by telephone on the day after surgery.
  
  
  RESULTS
  Pain scores were low in all four groups. Midazolam-alfentanil reduced pain perception, and all iv sedation used reduced pain recall. Midazolam reduced systolic BP; alfentanil +/- midazolam reduced HR. All iv sedation reduced SpO2 more than did saline, but not usually to a clinically important level. Nine patients had a SpO2 < or = 90%; all had received alfentanil with or without midazolam. It was not possible to predict oxygen saturation levels by any factors other than iv sedation and baseline SpO2 levels.
  
  
  CONCLUSIONS
  Intravenous sedation with midazolam or alfentanil or in combination reduced pain perception, pain recall, and haemodynamic responses from peribulbar anaesthesia. Fifteen percent of patients given alfentanil developed clinically important oxygen desaturation. The use of fine gauge needles combined with slow injection of anaesthetic solution causes minimal discomfort, and routine iv sedation may be unnecessary.
authors.affiliation: Department of Anaesthesia, University of British Columbia, Vancouver, Canada.
authors.forename: D H
authors.initials: DH
authors.lastname: Wong
authors.forename: P M
authors.initials: PM
authors.lastname: Merrick
mesh_terms: D000368:Aged; D015760:Alfentanil / Q000008:administration & dosage*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D002387:Cataract Extraction; D004311:Double-Blind Method; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D008297:Male; D008874:Midazolam / Q000008:administration & dosage*; D008875:Middle Aged; D009407:Nerve Block
chemical_list: D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D015760:Alfentanil; D008874:Midazolam