[Flow cytometry in the determination of DNA aneuploidy in patients with acute leukemias].
Bone marrow cellular DNA content was measured by flow cytometry in 107 adult patients with various types of acute leukemia. DNA-aneuploidy was detected in 28 of 107 patients (26%). In 18 patients with DNA-aneuploidy bone marrow was examined throughout 2-36 months. DNA-flow cytometry of bone marrow allows to determine DNA content in leukemia cells and distinguish hypodiploid, diploid, hyperdiploid and tetraploid DNA clones in patients with acute leukemia. In some cases this method allows monitoring of the minimal residual disease.
Shmarov
D A
DA
Kuchma
Iu M
IuM
Miterev
G Iu
GIu
Kozinets
G I
GI
D000208:Acute Disease; D000328:Adult; D000782:Aneuploidy; D001853:Bone Marrow / Q000648:ultrastructure; D004273:DNA, Neoplasm / Q000235:genetics*; D005434:Flow Cytometry / Q000295:instrumentation / Q000379:methods; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D012074:Remission Induction
D004273:DNA, Neoplasm