An adduct between peroxynitrite and 2'-deoxyguanosine: 4,5-dihydro-5-hydroxy-4-(nitrosooxy)-2'-deoxyguanosine.
The reactivity of peroxynitrite (OONO-) with DNA is of interest because it is is released during chronic inflammation, a major contributor to cancer. Peroxynitrite was found to undergo homolytic addition to the C4-C5 double bond of 2'-deoxyguanosine with formation of 4,5-dihydro-5-hydroxy-4-(nitrosooxy)-2'-deoxyguanosine (nox-dG). This adduct may be a useful marker in the study of the chemical processes associated with the mutagenicity of peroxynitrite.
Douki
T
T
Département de Recherche Fondamentale sur la Matière Condensée, SESAM/LAN, Grenoble, France.
Cadet
J
J
Ames
B N
BN
D002851:Chromatography, High Pressure Liquid; D018736:DNA Adducts / Q000737:chemistry* / Q000302:isolation & purification; D003849:Deoxyguanosine / Q000737:chemistry*; D009153:Mutagens / Q000737:chemistry / Q000302:isolation & purification; D009566:Nitrates / Q000737:chemistry*
D018736:DNA Adducts; D009153:Mutagens; D009566:Nitrates; C039642:peroxynitric acid; D003849:Deoxyguanosine