title: Risk factors leading to ceftriaxone-associated biliary pseudolithiasis in children.
abstract: Between July, 1992 and June, 1994, 151 pediatric patients who had ceftriaxone therapy for probable or definite bacterial enteritis were prospectively evaluated by serial abdominal ultrasonography. All patients received a dose of > or = 50 mg/kg/day and for a duration of 3 or more days. Five patients developed gallbladder precipitates or pseudolithiasis during treatment. Fasting and patients older than 24 months were probably the significant risk factors associated with this phenomenon (p < 0.05). However, no significant differences in sex, dose (50 vs. > 50 mg/kg/day) or duration of therapy (< 5 vs. > 5 day) were observed between patients who received ceftriaxone with and without the development of this gallbladder abnormality.
authors.affiliation: Department of Pediatrics, Chang Gung Children's Hospital and Chang Gung Medical College, Taipei, Taiwan, R.O.C.
authors.forename: M S
authors.initials: MS
authors.lastname: Kong
authors.forename: C Y
authors.initials: CY
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D002443:Ceftriaxone / Q000009:adverse effects*; D002511:Cephalosporins / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D002769:Cholelithiasis / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012307:Risk Factors
chemical_list: D002511:Cephalosporins; D002443:Ceftriaxone