Immunhistological evaluation of Creutzfeldt-Jakob disease with reference to the type PrPres deposition.
German patients suspected of having Creutzfeldt-Jakob disease (CJD) and related diseases were studied pathologically. The immunohistochemical findings after hydrolytic autoclaving pretreatment sensitively detected the synaptic-type deposition of the protease-resistant isoform of the prion protein (PrPres which thus served to establish the consensus diagnosis of CJD.
Tateishi
J
J
Department of Neuropathology, Neurological Institute Kyushu University, Fukuoka, Japan.
Kitamoto
T
T
Kretzschmar
H
H
Mehraein
P
P
D000368:Aged; D002675:Child, Preschool; D007562:Creutzfeldt-Jakob Syndrome / Q000276:immunology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018620:PrPSc Proteins / Q000032:analysis*
D018620:PrPSc Proteins