High-dose-rate intraoperative radiation therapy for colorectal cancer.
Intraoperative radiation therapy (IORT) has the obvious advantage of maximally irradiating the tumor bed while eliminating surrounding normal organs from the field of radiation. This approach has been especially useful when the required radiation dose exceeds the tolerance dose of the surrounding normal tissues. However, the application of IORT has been significantly limited by cost, logistic issues, and technical problems related to delivering treatment to difficult anatomic areas. We have developed a new approach to IORT that obviates the need for patient transport: In a dedicated, shielded operating room, the surgery is performed and IORT is delivered via HDR remote afterloading. We have found this approach to be cost effective, logistically sound, and suitable for a wide range of anatomic sites. The technical aspects of the procedure, as well our preliminary results in colorectal cancer, will be presented.
Harrison
L B
LB
Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Enker
W E
WE
Anderson
L L
LL
D015179:Colorectal Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D007432:Intraoperative Period; D011878:Radiotherapy / Q000009:adverse effects / Q000191:economics / Q000379:methods; D011879:Radiotherapy Dosage