A study on carcinogenesis of endogenous nitrite and nitrosamine, and prevention of cancer.
Cancer patients show a salivary NO2- density that is twice that of healthy individuals. This indicates that endogenous NO2- is correlated with the cancer. By applying a culture medium modified by vitamin B1 or KCIO3, we have found that many bacteria in the human body (especially the bowels) can nitrify NH4+ to NO2-. NO2- can be combined with a second amine to form nitrosamine which is a carcinogen. We fed mice using G+ coccus, which can lead to a precancerous lesion and mammary carcinoma, and proved that nitrification in vivo is carcinogenic. We have tested a method to prevent cancer in 7392 workers. Patients with a salivary density of NO2- over 10 ppm for 3 consecutive days and with light symptoms were our targets for preventive treatment using antibiotics and nitrosamine destroyers. The result shows that the average cancer incidence rate in the control group is 58.4% higher than in the experimental group over 9 years. The difference between the two groups is statistically significant (x2 = 8.5, p < 0.01). This is reliable evidence that preventive treatment is effective when based on the idea that endogenous NO2- and nitrosamine are the carcinogens.
Huang
Y G
YG
Hangzhou Municipal No. II Hospital, Zhejiang, PR China.
Ji
J D
JD
Hou
Q N
QN
D000328:Adult; D000368:Aged; D000641:Ammonia / Q000378:metabolism; D002274:Carcinogens, Environmental / Q000494:pharmacology*; D002681:China; D003248:Constipation / Q000378:metabolism; D006801:Humans; D007422:Intestines / Q000382:microbiology; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000401:mortality; D009573:Nitrites / Q000032:analysis / Q000378:metabolism*; D009602:Nitrosamines / Q000378:metabolism / Q000494:pharmacology*; D012463:Saliva / Q000737:chemistry*
D002274:Carcinogens, Environmental; D009573:Nitrites; D009602:Nitrosamines; D000641:Ammonia