Presence of human herpesvirus 6 variants A and B in saliva and peripheral blood mononuclear cells of healthy adults.
Saliva and peripheral blood mononuclear cells (PBMCs) from 44 healthy young adults were tested for human herpesvirus 6 variants A and B (HHV-6A and -6B) DNA by a sensitive nested PCR. HHV-6B infection was ascertained in 98% of the subjects, and 95% were found to excrete variant B in their saliva. HHV-6A was found in the PBMCs of 16%, but was not detected in saliva samples.
Aberle
S W
SW
Institute of Virology, University of Vienna, Austria.
Mandl
C W
CW
Kunz
C
C
Popow-Kraupp
T
T
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D002353:Carrier State / Q000276:immunology / Q000821:virology; D004279:DNA, Viral / Q000097:blood / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D006566:Herpesviridae Infections / Q000276:immunology / Q000821:virology; D015654:Herpesvirus 6, Human / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000821:virology*; D008297:Male; D016133:Polymerase Chain Reaction / Q000379:methods / Q000706:statistics & numerical data; D012463:Saliva / Q000821:virology*; D012680:Sensitivity and Specificity
D000914:Antibodies, Viral; D004279:DNA, Viral