title: Effects of sedation with detomidine hydrochloride on echocardiographic measurements of cardiac dimensions and indices of cardiac function in horses.
abstract: Twenty-six horses were sedated with detomidine hydrochloride (Domosedan, SmithKline Beecham Animal Health, Tadworth, Surrey, UK) at a dose of 10 micrograms/kg bwt, administered i.v. Echocardiograms were recorded before and after sedation, measurements of cardiac dimensions were made and functional indices were calculated. The pre- and post sedation values were compared. No significant change was detected following sedation in the ejection time (ET), left ventricular dimension, left atrial diameter at the sinotubular junction at end-systole or end-diastole or at the sinus of Valsalva at end-diastole. Sedation was found to result in a statistically significant increase in end-systolic left ventricular diameter and internal area and aortic diameter measured at the sinus of Valsalva. Left ventricular free-wall thickness and interventricular septal thickness at end-systole, fractional shortening, fractional area change and heart rate were significantly reduced following sedation. A significant increase in pre-ejection period (PEP), duration of electromechanical systole (EMS) and PEP/ET (ejection time) was detected.
authors.affiliation: Department of Clinical Veterinary Science, University of Bristol, Avon, UK.
authors.forename: M W
authors.initials: MW
authors.lastname: Patteson
authors.forename: C
authors.initials: C
authors.lastname: Gibbs
authors.forename: P R
authors.initials: PR
authors.lastname: Wotton
authors.forename: P J
authors.initials: PJ
authors.lastname: Cripps
mesh_terms: D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects; D003971:Diastole / Q000502:physiology; D004452:Echocardiography / Q000379:methods / Q000662:veterinary*; D006321:Heart / Q000033:anatomy & histology* / Q000187:drug effects / Q000502:physiology*; D006736:Horses / Q000033:anatomy & histology* / Q000502:physiology*; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D012850:Sinus of Valsalva / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000502:physiology; D013599:Systole / Q000502:physiology
chemical_list: D006993:Hypnotics and Sedatives; D007093:Imidazoles; C041255:detomidine