Effect of a herbomineral preparation D-400 in streptozotocin-induced diabetic rats.
This study was undertaken to investigate the effect of D-400, a herbomineral formulation on blood sugar and other biochemical parameters in streptozotocin-induced diabetic rats. There was significant reduction in blood urea nitrogen, serum creatinine and serum uric acid levels in the D-400-treated group and considerable lowering of AUC in oral glucose tolerance test (OGTT). The D-400-treated group showed significant lowering of triglycerides and HDL cholesterol. There was a rise in hepatic glycogen level close to normal after D-400 treatment. In the pancreas of diabetic rats, D-400 therapy showed significant increase in islet number and beta cell count and appeared to bring about blood sugar homoeostasis by increasing insulin secretion and repair/regeneration of endocrine pancreas.
Mitra
S K
SK
Research and Development Centre, Himalaya Drug Co., Makali, Bangalore, India.
Gopumadhavan
S
S
Muralidhar
T S
TS
Anturlikar
S D
SD
Sujatha
M B
MB
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D001806:Blood Urea Nitrogen; D002452:Cell Count / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004195:Disease Models, Animal; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000166:cytology / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects / Q000473:pathology; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D013311:Streptozocin / Q000008:administration & dosage / Q000633:toxicity; D014527:Uric Acid / Q000097:blood
D001786:Blood Glucose; C095293:D 400; D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts; D014527:Uric Acid; D013311:Streptozocin; D003404:Creatinine