title: Inhibitors of bacterial signal peptidase: a series of 6-(substituted oxyethyl)penems.
abstract: A series of 6-(substituted oxyethyl)penem esters having the (5S) stereochemistry which are potent inhibitors of Escherichia coli leader peptidase is described. Structure-activity relationships are discussed.
authors.affiliation: SmithKline Beecham Pharmaceuticals, Betchworth, Surrey, UK.
authors.forename: A
authors.initials: A
authors.lastname: Allsop
authors.forename: G
authors.initials: G
authors.lastname: Brooks
authors.forename: P D
authors.initials: PD
authors.lastname: Edwards
authors.forename: A C
authors.initials: AC
authors.lastname: Kaura
authors.forename: R
authors.initials: R
authors.lastname: Southgate
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004926:Escherichia coli / Q000201:enzymology*; D007769:Lactams / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008565:Membrane Proteins; D012697:Serine Endopeptidases / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D007769:Lactams; D008565:Membrane Proteins; C102428:allyl 6-(1'-acetoxyethyl)penem-3-carboxylate; C102427:allyl 6-(1'-hydroxyethyl)penem-3-carboxylate; D012697:Serine Endopeptidases; C026515:type I signal peptidase