Collagenous macrophage scavenger receptors.
Collagen, the most abundant protein in the human body, is a major constituent of extracellular matrix. Among macrophage membrane proteins, type I and II scavenger receptors and MARCO contain a collagenous domain. Analysis of type I and II receptor knockout mice and histochemical studies indicate that these proteins play roles in scavenger, adhesion and host defense functions of macrophages.
Kodama
T
T
Department of Molecular Biology and Medicine, University of Tokyo, Japan.
Doi
T
T
Suzuki
H
H
Takahashi
K
K
Wada
Y
Y
Gordon
S
S
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001161:Arteriosclerosis / Q000235:genetics / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism; D003094:Collagen / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008264:Macrophages / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D011971:Receptors, Immunologic / Q000378:metabolism*; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B
D002352:Carrier Proteins; D015815:Cell Adhesion Molecules; C490460:MARCO protein, human; C092228:Marco protein, mouse; D008565:Membrane Proteins; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; C454739:Scarb1 protein, mouse; D051122:Scavenger Receptors, Class B; D003094:Collagen