title: Markers of oxidative stress before and after exchange transfusion for neonatal sepsis.
abstract: Oxidative status before and after ET was assessed in eight septic newborns who received exchange transfusion (ET). Short-term elevations of conjugated dienes (CDs) and thiobarbituric acid reactive substances (TBARSs) (p < 0.05) and increased serum antioxidant capacity (AOC) (p = 0.06) were noted. Chromatographic migration of the red blood cells (CM RBCs), a measure of RBC deformability, also improved after ET. ET for neonatal sepsis does not cause significant oxidative stress; rather, it may help to restore the antioxidant depots and improve RBC deformability and microcirculation.
authors.affiliation: Intensive Care Unit of the Children's Hospital, Tartu University, Estonia.
authors.forename: T
authors.initials: T
authors.lastname: Kokk
authors.forename: R
authors.initials: R
authors.lastname: Talvik
authors.forename: M
authors.initials: M
authors.lastname: Zilmer
authors.forename: E
authors.initials: E
authors.lastname: Kütt
authors.forename: T
authors.initials: T
authors.lastname: Talvik
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D001803:Blood Transfusion; D004912:Erythrocytes / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D015227:Lipid Peroxidation; D008833:Microcirculation; D018384:Oxidative Stress; D018805:Sepsis / Q000378:metabolism / Q000628:therapy*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000975:Antioxidants; D017392:Thiobarbituric Acid Reactive Substances