title: [Antibiotic-induced prolonged cholestasis: suspected induction by ceftibuten].
abstract: We report on a 43-year-old female diabetic patient who was treated with ceftibuten because of Pseudomonas aeruginosa induced otitis externa. Thereafter she developed a prolonged seven-months-persisting irreversible cholestasis. Liver puncutre revealed a canalicular and hepatocellular cholestasis without liver cell necrosis or bile duct injury. After seven-months the patient died because of antibiotic-resistant Pseudomonas-septicemia.
authors.affiliation: Medizinische Poliklinik, Ludwig-Maximilians-Universität München.
authors.forename: C
authors.initials: C
authors.lastname: Combe
authors.forename: B
authors.initials: B
authors.lastname: Banas
authors.forename: W G
authors.initials: WG
authors.lastname: Zoller
authors.forename: M P
authors.initials: MP
authors.lastname: Manns
authors.forename: D
authors.initials: D
authors.lastname: Schlöndorff
mesh_terms: D000328:Adult; D000077722:Ceftibuten; D018550:Cephalosporin Resistance; D002511:Cephalosporins / Q000009:adverse effects* / Q000627:therapeutic use; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D010032:Otitis Externa / Q000188:drug therapy* / Q000473:pathology; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000473:pathology; D018805:Sepsis / Q000139:chemically induced / Q000473:pathology
chemical_list: D002511:Cephalosporins; D000077722:Ceftibuten