Neurologic manifestations of HIV infection.
A wide spectrum of central and peripheral nervous system abnormalities may be associated with HIV infection. These disorders may be caused by HIV infection, result as secondary complications related to immunosuppression, or be a neurotoxic effect of therapeutic agents. The range of neurologic disorders includes dementia, focal cerebral mass lesions, myelopathy, peripheral neuropathies, and myopathy. Early diagnosis and therapy is critical, and may result in substantial improvement in patients' quality and quantity of life. This article reviews the approach to differential diagnosis of these neurologic disorders and presents theories of pathogenesis and current approaches to treatment.
Simpson
D M
DM
Department of Neurology, Mount Sinai Medical Center (DMS), New York, New York, USA.
Berger
J R
JR
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D009422:Nervous System Diseases / Q000150:complications* / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents