Localization of motor- and nonmotor-related neurons within the matrix-striosome organization of rat striatum.
Striatal neurons can be classified as movement- and nonmovement-related depending on their ability to change firing rate in close temporal association with spontaneous movement in an open-field arena. The present study assessed the location of these cell types within the compartmental organization of the striatum by combining single-unit recording techniques in freely moving rats with calbindin immunohistochemistry. Movement-related neurons were found predominately either in the matrix or along the matrix-striosome border. Most of these neurons were nonselective in that they increased activity whenever the animals changed from a quiet resting posture to any form of behavioral activation (e.g., grooming, locomotion, rearing). The remaining neurons in this group responded exclusively to movements of the head. Nonselective units discharged at a significantly slower rate than head-movement units during both quiet rest and periods of actual movement. Nonmovement-related neurons, which failed to show a reliable change in activity to overt behavior, comprised a relatively small portion of the neuronal sample but were also located in either the matrix or along the matrix-striosome border. Collectively, these results suggest that even though striatal neurons can be distinguished on the basis of their responsiveness to ongoing behavior in an open-field paradigm, such distinctions are not clearly linked to sites within the matrix or its striosomal borders.
Trytek
E S
ES
Medical Sciences Program, Indiana University, Bloomington 47405, USA.
White
I M
IM
Schroeder
D M
DM
Heidenreich
B A
BA
Rebec
G V
GV
D000818:Animals; D064026:Calbindins; D004567:Electrodes, Implanted; D004594:Electrophysiology; D007150:Immunohistochemistry; D008297:Male; D009046:Motor Neurons / Q000502:physiology* / Q000648:ultrastructure; D009068:Movement / Q000502:physiology; D017072:Neostriatum / Q000166:cytology* / Q000502:physiology / Q000648:ultrastructure; D009474:Neurons / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D064030:S100 Calcium Binding Protein G / Q000378:metabolism
D064026:Calbindins; D064030:S100 Calcium Binding Protein G