title: Chamber challenges: the necessity of objective observation.
abstract: the specialty of Allergy-Immunology has used human challenge testing procedures to test theories of causal relationships for decades. This includes highly characterized airborne allergens and chemicals with allergic sensitization potential. The utility of such testing to establish allergic sensitivity is well accepted. The causal relationship of chemical exposure and myriad clinical syndromes is a very contentious issue. The completion of the challenge chamber facility at EPA's Human Exposure Research Facility presents a grand opportunity for government investigators to work harmoniously with other government investigators in an effort to bring the redeeming spotlight of scientific discipline to the testy considerations of multiple chemical sensitivity, chronic fatigue, and Gulf War illness phenomena.
authors.affiliation: Department of Pediatrics, University of Colorado, Health Science Center, Denver, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Selner
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects*; D000402:Airway Obstruction / Q000209:etiology; D000485:Allergens / Q000009:adverse effects; D000818:Animals; D001273:Atmosphere Exposure Chambers; D018876:Environmental Illness / Q000209:etiology*; D015673:Fatigue Syndrome, Chronic / Q000209:etiology; D006801:Humans; D018777:Multiple Chemical Sensitivity / Q000209:etiology; D009299:Nasal Provocation Tests; D009657:North Carolina; D018923:Persian Gulf Syndrome / Q000209:etiology; D010796:Phthalic Anhydrides / Q000009:adverse effects; D012997:Solvents / Q000009:adverse effects; D014051:Toluene 2,4-Diisocyanate / Q000009:adverse effects; D014481:United States; D014484:United States Environmental Protection Agency
chemical_list: D000393:Air Pollutants; D000485:Allergens; D010796:Phthalic Anhydrides; D012997:Solvents; D014051:Toluene 2,4-Diisocyanate; C015559:trimellitic anhydride