Properties of an oxygen-sensitive mutant mev-3 of the nematode Caenorhabditis elegans.
A spontaneous mutant of mev-3 of the nematode Caenorhabditis elegans was isolated on the basis of its resistance to methyl viologen, which generates superoxide radicals. Contrary to expectation, the mutant proved hypersensitive to oxygen. Oxygen retarded development and reduced fecundity in a concentration-dependent fashion in mev-3 but not in wild-type. In addition, the mean life span of mev-3 (but not wild-type) was progressively shortened when animals were incubated under 70% oxygen.
Yamamoto
K
K
Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan.
Honda
S
S
Ishii
N
N
D000375:Aging / Q000187:drug effects / Q000235:genetics; D000818:Animals; D001824:Body Constitution / Q000235:genetics; D017173:Caenorhabditis elegans / Q000235:genetics*; D005298:Fertility / Q000187:drug effects / Q000235:genetics; D008017:Life Expectancy; D009154:Mutation / Q000235:genetics*; D010100:Oxygen / Q000378:metabolism / Q000494:pharmacology*; D010269:Paraquat / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism
D017382:Reactive Oxygen Species; D010269:Paraquat; D010100:Oxygen