title: Analysis of the concentration and output of whole salivary constituents in patients with Sjögren's syndrome.
abstract: In Sjögren's syndrome, salivary glands are affected, resulting in a diminished salivary flow. In the present study, the protein composition, sialic acid content and the amounts of calcium and phosphate of stimulated whole saliva from 43 patients with Sjögren's syndrome, were compared with those of control saliva samples from 17 healthy subjects. The absolute concentrations of albumin, cystatin C, cystatin S, total IgA and total protein, but not amylase, were increased significantly in both primary and secondary Sjögren's syndrome. The output/min of total protein, albumin, amylase, and IgA was, however, decreased in Sjögren patients. These results suggest that the diminished output of salivary defence factors, rather than their absolute concentrations, may be related to the oral health problems seen in Sjögren's syndrome patients.
authors.affiliation: Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), The Netherlands. wa.van-der-reijden.obc.acta@med.vu.nl
authors.forename: W A
authors.initials: WA
authors.lastname: van der Reijden
authors.forename: J S
authors.initials: JS
authors.lastname: van der Kwaak
authors.forename: E C
authors.initials: EC
authors.lastname: Veerman
authors.forename: A V
authors.initials: AV
authors.lastname: Nieuw Amerongen
mesh_terms: D000328:Adult; D000368:Aged; D000418:Albumins / Q000032:analysis; D000681:Amylases / Q000032:analysis; D002118:Calcium / Q000032:analysis; D055316:Cystatin C; D015891:Cystatins / Q000032:analysis; D015853:Cysteine Proteinase Inhibitors / Q000032:analysis; D005260:Female; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000032:analysis; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism; D055333:Salivary Cystatins; D012469:Salivary Glands / Q000378:metabolism; D012471:Salivary Proteins and Peptides / Q000032:analysis; D012636:Secretory Rate; D012794:Sialic Acids / Q000032:analysis; D012859:Sjogren's Syndrome / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D000418:Albumins; C525030:CST3 protein, human; C525173:CST4 protein, human; D055316:Cystatin C; D015891:Cystatins; D015853:Cysteine Proteinase Inhibitors; D007071:Immunoglobulin A, Secretory; D010710:Phosphates; D055333:Salivary Cystatins; D012471:Salivary Proteins and Peptides; D012794:Sialic Acids; D000681:Amylases; D002118:Calcium