Radioligand binding studies on some dihydropyridine analogues as probes of the dihydropyridine receptor.
The affinity of two compounds, closely related to 1,4-dihydropyridines, was determined in competition binding experiments using canine cerebral cortex membranes and [3H]nitrendipine as a radioligand. Some aspects of structure-affinity relationships are discussed in relation to existing models of the dihydropyridine binding site.
Kettmann
V
V
Department of Analytical Chemistry, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republik.
Drímal
J
J
Svétlík
J
J
D000818:Animals; D002121:Calcium Channel Blockers / Q000493:pharmacokinetics; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism*; D020746:Calcium Channels, L-Type; D002540:Cerebral Cortex / Q000378:metabolism; D004095:Dihydropyridines / Q000138:chemical synthesis; D004285:Dogs; D066298:In Vitro Techniques; D008297:Male; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000187:drug effects / Q000378:metabolism*; D009568:Nitrendipine / Q000493:pharmacokinetics; D011869:Radioligand Assay; D013329:Structure-Activity Relationship
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D020746:Calcium Channels, L-Type; D004095:Dihydropyridines; D009419:Nerve Tissue Proteins; D009568:Nitrendipine