Blockade by ginseng total saponin of methamphetamine-induced hyperactivity and conditioned place preference in mice.
Ginseng total saponin (GTS) inhibited methamphetamine-induced hyperactivity and conditioned place preference (CPP). Dopamine (DA) receptor supersensitivity was developed in methamphetamine-induced CPP mice and it was inhibited by GTS. GTS also inhibited apomorphine-induced climbing behavior, showing the antidopaminergic activity of GTS. These results suggest that GTS inhibition of the methamphetamine-induced hyperactivity and CPP may be closely related with the inhibition of dopaminergic activation induced by methamphetamine.
Kim
H S
HS
Department of Pharmacology, Chungbuk National University, Cheongju, Korea.
Jang
C G
CG
Park
W K
WK
Oh
K W
KW
Rheu
H M
HM
Cho
D H
DH
Oh
S
S
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D000697:Central Nervous System Stimulants / Q000037:antagonists & inhibitors*; D018491:Dopamine Agonists / Q000494:pharmacology; D006702:Homing Behavior; D008297:Male; D008694:Methamphetamine / Q000037:antagonists & inhibitors*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D005894:Panax; D010946:Plants, Medicinal; D012503:Saponins / Q000494:pharmacology*
D000697:Central Nervous System Stimulants; D018491:Dopamine Agonists; D012503:Saponins; D008694:Methamphetamine; D001058:Apomorphine