title: Assessment of myocardial viability in patients with chronic coronary artery disease. Rest-4-hour-24-hour 201Tl tomography versus dobutamine echocardiography.
abstract: BACKGROUND
  To date, late redistribution after resting 201Tl injection has not been evaluated. In addition, the concordance between resting 201Tl imaging and dobutamine echocardiography in identifying viable myocardium has not been assessed.
  
  
  RESULTS
  Forty patients with coronary artery disease underwent rest-4-hour-24-hour 201Tl tomography and dobutamine echocardiography (5 to 10 micrograms.kg-1.min-1). Late redistribution occurred in 46 (21%) of 219 persistent defects at 4 hours. Systolic function and contractile reserve were similar among persistent defects at 4 hours with and without late redistribution. Contractile reserve was more frequent in segments with normal 201Tl uptake (59%), completely reversible defects (53%), or mild to moderate defects at 4 hours (56%) compared with severe defects (14%; P < .02 versus all). Of 105 hypokinetic segments, 99 (94%) were viable by 201Tl, and 88 (84%) showed contractile reserve. In contrast, of 155 akinetic segments, 119 (77%) were viable by 201Tl, but only 34 (22%) had contractile reserve. Concordance between 201Tl and dobutamine was 82% in hypokinetic segments but 43% in akinetic segments. In 109 revascularized segments, positive accuracy for functional recovery was 72% for 201Tl and 92% for dobutamine, whereas negative accuracy was 100% and 65%, respectively. Sensitivity was 100% for 201Tl and 79% for dobutamine.
  
  
  CONCLUSIONS
  Late redistribution occurs in one fifth of persistent defects at 4 hours, and it does not correlate to systolic function or contractile reserve. Dobutamine and 201Tl yield concordant information in the majority of hypokinetic segments, whereas concordance is low in akinetic segments. Dobutamine demonstrates higher positive accuracy and sensitivity in predicting recovery of dysfunctional myocardium, whereas 201Tl shows higher negative predictive accuracy but reduced positive accuracy.
authors.affiliation: Division of Cardiology, Federico II University Medical School, Naples, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Perrone-Filardi
authors.forename: L
authors.initials: L
authors.lastname: Pace
authors.forename: M
authors.initials: M
authors.lastname: Prastaro
authors.forename: F
authors.initials: F
authors.lastname: Squame
authors.forename: S
authors.initials: S
authors.lastname: Betocchi
authors.forename: A
authors.initials: A
authors.lastname: Soricelli
authors.forename: F
authors.initials: F
authors.lastname: Piscione
authors.forename: C
authors.initials: C
authors.lastname: Indolfi
authors.forename: T
authors.initials: T
authors.lastname: Crisci
authors.forename: M
authors.initials: M
authors.lastname: Salvatore
authors.forename: M
authors.initials: M
authors.lastname: Chiariello
mesh_terms: D000368:Aged; D002470:Cell Survival; D002908:Chronic Disease; D002940:Circadian Rhythm; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004280:Dobutamine; D004452:Echocardiography; D005500:Follow-Up Studies; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D009204:Myocardial Revascularization; D011877:Radionuclide Imaging; D012146:Rest; D013599:Systole; D013794:Thallium Radioisotopes / Q000493:pharmacokinetics; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000628:therapy
chemical_list: D013794:Thallium Radioisotopes; D004280:Dobutamine