title: Pyrrolosporin A, a new antitumor antibiotic from Micromonospora sp. C39217-R109-7. I. Taxonomy of producing organism, fermentation and biological activity.
abstract: Strain C39217-R109-7 (ATCC 53791) is an actinomycete strain isolated from a soil sample collected at Puerto Viejo, Peru. It produces a new antitumor antibiotic, designated pyrrolosporin A. Taxonomic studies on its morphological, cultural and physiological characteristics identified this producing strain as Micromonospora sp. C39217-R109-7. Pyrrolosporin A shows antimicrobial activity against Gram-positive bacteria and it is weakly active against Gram-negative bacteria. Pyrrolosporin A prolongs the life span of mice inoculated with P388 leukemia cells.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492, USA.
authors.forename: K S
authors.initials: KS
authors.lastname: Lam
authors.forename: G A
authors.initials: GA
authors.lastname: Hesler
authors.forename: D R
authors.initials: DR
authors.lastname: Gustavson
authors.forename: R L
authors.initials: RL
authors.lastname: Berry
authors.forename: K
authors.initials: K
authors.lastname: Tomita
authors.forename: J L
authors.initials: JL
authors.lastname: MacBeth
authors.forename: J
authors.initials: J
authors.lastname: Ross
authors.forename: D
authors.initials: D
authors.lastname: Miller
authors.forename: S
authors.initials: S
authors.lastname: Forenza
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000378:metabolism* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005285:Fermentation / Q000502:physiology*; D007218:Industrial Microbiology / Q000379:methods; D007938:Leukemia / Q000188:drug therapy; D018942:Macrolides; D051379:Mice; D008815:Mice, Inbred Strains; D008826:Microbial Sensitivity Tests; D008847:Micromonospora / Q000145:classification / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D018942:Macrolides; C102425:pyrrolosporin A