title: Polarographic behavior of kojic acid and its derivatives, determination of potential carcinogenicity and correlation of these properties with their other attributes.
abstract: Polarographic properties of kojic acid [5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one] and 10 of their synthetic derivatives were investigated. It was shown that these compounds are reduced in anhydrous conditions, usually in one two-electron step or in two one-electron steps. The presence of some substituents may change the course of reduction process. The polarography of these compounds in the presence of alpha-lipoic acid showed the kojic acid analog-alpha-lipoic acid complex formation. The determined potential carcinogenic activity of these compounds expressed as a parameter tg alpha is not substantial.
authors.affiliation: Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovakia.
authors.forename: A
authors.initials: A
authors.lastname: Vachálková
authors.forename: J
authors.initials: J
authors.lastname: Bransová
authors.forename: J
authors.initials: J
authors.lastname: Brtko
authors.forename: M
authors.initials: M
authors.lastname: Uher
authors.forename: L
authors.initials: L
authors.lastname: Novotný
mesh_terms: D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000737:chemistry* / Q000633:toxicity*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004126:Dimethylformamide / Q000737:chemistry; D004566:Electrodes; D008628:Mercury / Q000737:chemistry; D009183:Mycotoxins / Q000737:chemistry* / Q000633:toxicity*; D010084:Oxidation-Reduction; D011048:Polarography; D011753:Pyrones / Q000737:chemistry* / Q000633:toxicity*; D013329:Structure-Activity Relationship; D008063:Thioctic Acid / Q000737:chemistry
chemical_list: D002273:Carcinogens; D009183:Mycotoxins; D011753:Pyrones; C011890:kojic acid; D008063:Thioctic Acid; D004126:Dimethylformamide; D008628:Mercury