title: The effects of long-term low-protein intake on gastrin cells of the rat antral mucosa during adulthood.
abstract: The effect of experimental protein malnutrition on gastrin producing cells in the antral part of the stomach was studied in male Wistar rats. Isoenergetic diets containing 25% (C-25) or 6% (PD-6) were given in isocaloric amounts during a 4-month experiment. All rats were offered drinking water ad libitum. The results showed that the long-term protein diet did not produce changes in the gastrin cell number. At the ultrastructural level G cells exhibited a decreased size of the nucleus. They were found to have an increased total granule volume density but the volume density of dense-cored granules was lower. The serum gastrin levels were significantly lowered by feeding the low protein diet. These changes are compatible with decreased functional activity of G cells under long-term protein deprivation.
authors.affiliation: Institute for Medical Research, Faculty of Medicine, Belgrade, Yugoslavia.
authors.forename: J
authors.initials: J
authors.lastname: Varagic
authors.forename: V
authors.initials: V
authors.lastname: Koko
authors.forename: V
authors.initials: V
authors.lastname: Todorovic
authors.forename: Z
authors.initials: Z
authors.lastname: Bozovic
authors.forename: V
authors.initials: V
authors.lastname: Lackovic
authors.forename: V
authors.initials: V
authors.lastname: Vuzevski
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000473:pathology / Q000648:ultrastructure; D003593:Cytoplasm / Q000473:pathology / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000473:pathology / Q000648:ultrastructure; D002149:Energy Intake; D005753:Gastric Mucosa / Q000166:cytology / Q000473:pathology*; D005755:Gastrins / Q000032:analysis*; D008297:Male; D008854:Microscopy, Electron; D011502:Protein-Energy Malnutrition / Q000473:pathology* / Q000503:physiopathology; D011706:Pyloric Antrum; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D013997:Time Factors
chemical_list: D005755:Gastrins