Design, synthesis, and evolution of a novel, selective, and orally bioavailable class of thrombin inhibitors: P1-argininal derivatives incorporating P3-P4 lactam sulfonamide moieties.
Semple
J E
JE
Corvas International, Inc., San Diego, California 92121-1102, USA. ed_semple@corvas.com
Rowley
D C
DC
Brunck
T K
TK
Ha-Uong
T
T
Minami
N K
NK
Owens
T D
TD
Tamura
S Y
SY
Goldman
E A
EA
Siev
D V
DV
Ardecky
R J
RJ
Carpenter
S H
SH
Ge
Y
Y
Richard
B M
BM
Nolan
T G
TG
Håkanson
K
K
Tulinsky
A
A
Nutt
R F
RF
Ripka
W C
WC
D000818:Animals; D000991:Antithrombins / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D001120:Arginine / Q000737:chemistry*; D001682:Biological Availability; D004285:Dogs; D015195:Drug Design; D007769:Lactams / Q000737:chemistry*; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000991:Antithrombins; D007769:Lactams; D001120:Arginine