Serum levels of articaine 2% and 4% in children.
The results of the present study of the pharmacokinetics of articaine in children show serum concentrations comparable to those in adults. The maximum values are distinctly lower with the 2% articaine solution. The t max found in our investigation was distinctly earlier than in comparable investigations on adults, whereas the plasma clearance was increased. There is no need to fix a lower mg/kg articaine dose limit for children because of age-related differences in the pharmacokinetics. The use of 2% articaine in pediatric dentistry is particularly advantageous because of the lower C max and the shorter half-life.
Jakobs
W
W
Privatuniversität Witten, Germany.
Ladwig
B
B
Cichon
P
P
Ortel
R
R
Kirch
W
W
D000766:Anesthesia, Dental / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics*; D002355:Carticaine / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics*; D002648:Child; D002675:Child, Preschool; D019140:Dental Care for Children / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate
D000779:Anesthetics, Local; D002355:Carticaine