title: [Gastric mucosal congestion following endoscopic variceal ligation--analysis using reflectance spectrophotometry].
abstract: Endoscopic variceal ligation (EVL) has been accepted as a new treatment for esophageal varices in cirrhotic patients, and evaluated to have a lower incidence of complications compared to sclerotherapy. Sclerotherapy may increase the risk of portal hypertensive gastropathy (PHG), which is recognized to be gastric mucosal congestion due to portal hypertension in cirrhotics. However, the gastric mucosal hemodynamics after EVL has not been established yet. The aim of this study is to assess whether EVL could affect the hemodynamics of the gastric mucosa.
  
  
  METHODS
  Eleven cirrhotic patients with severe esophageal varices, who underwent prophylactic EVL were enrolled in the trial. Age and sex-matched non-cirrhotic patients who had only gastric mucosal atrophy were entered as control to compare the mucosal hemodynamics to that of cirrhotic patient. EVL was performed as described by Stiegmann et al. The gastric mucosal hemodynamics was evaluated with both gastric mucosal blood volume (IHB) and hemoglobin O2 saturation (ISO2), which were measured by reflectance spectrophotometry during endoscopy. These parameters were measured in the three points of the stomach (gastric antrum, lower corpus and upper corpus) just before and after EVL.
  
  
  RESULTS
  In all patients with cirrhosis, mild PHG was observed endoscopically. ISO2 in cirrhotic patients was significantly lower in all points of the stomach compared with control. IHB in cirrhotic patients was not significantly different from control. ISO2 of post-EVL was significantly lower than that of pre-EVL, whereas IHB of post-EVL revealed significantly higher than that of pre-EVL. However, endoscopic grade of PHG remained mild. The hemodynamics of the mucosa two weeks after the initial EVL showed improvement of the congestion.
  
  
  CONCLUSIONS
  The gastric mucosal hemodynamics showed increment of the gastric blood volume and decreased hemoglobin O2 saturation in cirrhotic patients, indicating that cirrhotic gastric mucosa is in congestive condition. EVL for esophageal varices makes the gastric mucosa more congestive soon after the procedure in spite of the same grade of endoscopic PHG. However, the worsened congestion improves within a few weeks.
authors.affiliation: 2nd Department of Internal Medicine, Dokkyo University School of Medicine.
authors.forename: K
authors.initials: K
authors.lastname: Kanke
authors.forename: M
authors.initials: M
authors.lastname: Ishida
authors.forename: N
authors.initials: N
authors.lastname: Yajima
authors.forename: M
authors.initials: M
authors.lastname: Saito
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Masuyama
authors.forename: H
authors.initials: H
authors.lastname: Hiraishi
authors.forename: A
authors.initials: A
authors.lastname: Terano
mesh_terms: D000368:Aged; D004724:Endoscopy; D004932:Esophageal and Gastric Varices / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply*; D005773:Gastroscopy; D006439:Hemodynamics; D006801:Humans; D008026:Ligation; D008103:Liver Cirrhosis / Q000503:physiopathology; D008297:Male; D013053:Spectrophotometry / Q000379:methods