Structure-activity relationships of some 1,4-benzodioxane aryl-piperazine derivatives as alpha-blocking agents.
The synthesis of eight novel 1,4-benzodioxane derivatives is reported. The blocking activity of these compounds was determined on the pre- and postsynaptic alpha-adrenoceptors of isolated rat vas deferens. Structure-activity relationships are discussed.
Corsano
S
S
Istituto di Chimica e Tecnologia del Farmaco, Università di Perugia, Italy.
Strappaghetti
G
G
Scapicchi
R
R
Marucci
G
G
D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D004146:Dioxanes / Q000138:chemical synthesis* / Q000494:pharmacology*; D008297:Male; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
D000317:Adrenergic alpha-Antagonists; D004146:Dioxanes; D010879:Piperazines