Ca-ATPase and bone cell mineralization.
The plasma membrane Ca-ATPases play an important role in the regulation of intracellular Ca2+ ion concentration by pumping Ca2+ out of the cell into the extracellular fluid at the expense of ATP. These pumps potentially play an important role in the delivery of Ca2+ during mineralization of hard tissues such as bone. The properties of the plasma membrane Ca2+ pump are compared with those of the sarco(endo)plasmic reticulum and the factors regulating pump function are presented. The different gene products for the plasma membrane Ca-ATPases are described as well as their known functional significance. Particular attention is paid on the plasma membrane Ca2+ pumps present in mineralizing tissues and evidence supporting a role for these pumps in the transcellular delivery of Ca2+ during the process of mineralization is also presented.
Abramowitz
J
J
Department of Medicine, Baylor College of Medicine, Houston, Tex 77030, USA.
Suki
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WN
D000818:Animals; D001692:Biological Transport; D001842:Bone and Bones / Q000201:enzymology*; D002113:Calcification, Physiologic / Q000502:physiology*; D000252:Calcium-Transporting ATPases / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D002462:Cell Membrane / Q000201:enzymology; D004721:Endoplasmic Reticulum / Q000378:metabolism
D000252:Calcium-Transporting ATPases