Biochemical mass spectrometry: worth the weight?
The utility of mass spectrometry for the analysis of biological molecules has been enhanced by the development of two techniques that generate gas-phase ions via nondestructive vaporization and ionization. These techniques can be used not only to determine the primary structure of biological molecules with unprecedented accuracy, but also to map noncovalent biomolecular interactions.
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Department of Chemistry, The Scripps Research Institute, BCC-157, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. siuzdak@scripps.edu
Siuzdak
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D000803:Angiotensin I / Q000737:chemistry; D004247:DNA / Q000032:analysis / Q000737:chemistry; D007535:Isomerases / Q000737:chemistry; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*; D008970:Molecular Weight; D009844:Oligosaccharides / Q000032:analysis / Q000737:chemistry; D010455:Peptides / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D011506:Proteins / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D014357:Trypsin / Q000378:metabolism
D009844:Oligosaccharides; D010455:Peptides; D011506:Proteins; D004247:DNA; D000803:Angiotensin I; D014357:Trypsin; C021918:4-oxalocrotonate tautomerase; D007535:Isomerases