title: Development of the hematopoietic system.
abstract: Significant advances have been made in the past year in understanding hematopoietic development. Recent studies have clarified the origin and migration of stem cells in early embryos, established potential roles for homeodomain proteins in controlling the proliferation of progenitor cells and in patterning ventral mesoderm, and demonstrated the effects of nuclear proteins on lineage programming and apoptosis.
authors.affiliation: Howard Hughes Medical Institute, Division of Hematology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. Orkin@rascal.med.harvard.edu
authors.forename: S H
authors.initials: SH
authors.lastname: Orkin
mesh_terms: D000818:Animals; D017209:Apoptosis; D002454:Cell Differentiation; D002455:Cell Division; D002470:Cell Survival; D005314:Embryonic and Fetal Development; D005801:Genes, Homeobox; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000502:physiology*; D018398:Homeodomain Proteins / Q000502:physiology; D006801:Humans; D008648:Mesoderm / Q000502:physiology*; D008954:Models, Biological; D013234:Stem Cells / Q000166:cytology / Q000502:physiology
chemical_list: D018398:Homeodomain Proteins