Glomerular localization of interleukin-6 suppressed by steroid mini-pulse therapy in an IgA nephropathy patient.
A 16-year-old female with IgA nephropathy harboring histologically active lesions was treated with steroid mini-pulse therapy. Immunohistochemical examination revealed a diffuse distribution of interleukin-6 (IL-6) in the renal biopsy tissue. After treatment, her clinical factors and renal function improved, and renal biopsy showed reduced histological lesions and disappearance of the IL-6 distribution. Immunohistological studies of cytokines, such as IL-6, may be useful for evaluating the therapeutic effects in IgA nephropathy.
Taniguchi
Y
Y
Second Department of Internal Medicine, Hiroshima University School of Medicine.
Yorioka
N
N
Oda
H
H
Okushin
S
S
Nishida
Y
Y
Yamakido
M
M
Taguchi
T
T
D000293:Adolescent; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D005922:Glomerulonephritis, IGA / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000378:metabolism*; D013256:Steroids / Q000008:administration & dosage*
D015850:Interleukin-6; D013256:Steroids