title: Convulsions associated with epidural analgesia during sevoflurane anaesthesia.
abstract: A three-year-old girl who underwent an operation for adrenal neuroblastoma was anaesthetized with sevoflurane and epidural analgesia. In the immediate recovery period she had convulsions. The convulsions were successfully treated with thiopentone and sevoflurane, there were no neurological sequelae. The convulsions were considered to be a manifestation of mepivacaine toxicity because of a high plasma mepivacaine concentration. Complications of paediatric regional analgesia and manifestations of mepivacaine toxicity under sevoflurane anaesthesia are discussed.
authors.affiliation: Department of Anesthesiology, Jichi Medical School, Tochigi, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Saitoh
authors.forename: N
authors.initials: N
authors.lastname: Tsukamoto
authors.forename: H
authors.initials: H
authors.lastname: Mitsuhata
authors.forename: Y
authors.initials: Y
authors.lastname: Hirabayashi
authors.forename: R
authors.initials: R
authors.lastname: Shimizu
mesh_terms: D015360:Analgesia, Epidural / Q000009:adverse effects*; D000768:Anesthesia, General; D018685:Anesthetics, Inhalation; D000779:Anesthetics, Local / Q000009:adverse effects* / Q000097:blood; D002675:Child, Preschool; D004987:Ethers; D005260:Female; D006801:Humans; D008619:Mepivacaine / Q000009:adverse effects* / Q000097:blood; D008738:Methyl Ethers; D012640:Seizures / Q000139:chemically induced*; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D000779:Anesthetics, Local; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D008619:Mepivacaine