[Comparison of the therapeutic efficacy of the piperacillin/tazobactame combination vs. ampicillin and gentamycin in in the management of post-cesarean endometritis].
Traditionally obstetric infections have been treated with combination antimicrobial agents that provide coverage against aerobic and anaerobic bacteria commonly found in these infections. New antibiotics may be a monotherapy alternative for this type of infections. The objective of the study was to compare the efficacy of the agent piperacillin/tazobactam against ampicillin plus gentamicin in the treatment of postcesarean endometritis. By randomized way 14 patients were enrolled in the piperacillin/tazobactam group and 42 in the ampicillin-gentamicin group. A favorable clinical response occurred in 78.6% of piperacillin/tazobactam patients and 88.1% of ampicillin and gentamicin patients (p = NS). There was no statistically significant difference in the times to recovery and days of hospitalization between the two groups. The combination piperacillin/tazobactam did not show advantage towards the standard treatment, so combination antimicrobial agent continue been the optimal approach to the management of obstetric infection.
Figueroa-Damian
R
R
Departamento de Infectología e Inmunología, Instituto Nacional de Perinatología, México, D.F.
Villagrana-Zesati
R
R
San Martín-Herrasti
J M
JM
Arredondo-Garcia
J L
JL
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000667:Ampicillin / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002585:Cesarean Section / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D004716:Endometritis / Q000188:drug therapy / Q000209:etiology*; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D010298:Parity; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010406:Penicillins / Q000627:therapeutic use*; D010878:Piperacillin / Q000627:therapeutic use*; D011247:Pregnancy; D000078142:Tazobactam
D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D005839:Gentamicins; D010406:Penicillins; D000667:Ampicillin; D010397:Penicillanic Acid; D000078142:Tazobactam; D010878:Piperacillin