Capillary GC-ECD and ECNI GCMS characterization of toxaphene residues in primate tissues during a feeding study.
Toxaphene is a pesticide whose use was banned in North America because of concerns regarding its toxicity. To obtain better data on the metabolism and toxicity of toxaphene in primates, a one year feeding study was carried out in cynomologous monkeys at a dose of 1 mg/kg/day for one year. Levels of toxaphene residues in blood and adipose tissue during the dosing period were measured by GC-ECD and ECNI GCMS. The dosing toxaphene mixture was found to be extensively metabolized. Four chlorinated bornane congeners were the predominate residues found in the tissue samples. Blood levels of toxaphene residues plateaued at 40 ppb, adipose levels at approximately 4000 ppb. Kidney, liver, feces and urine were analyzed for toxaphene residues after necropsy.
Andrews
P
P
Food Research Division, Health Canada, Ottawa, Ontario.
Headrick
K
K
Pilon
J C
JC
Bryce
F
F
Iverson
F
F
D000273:Adipose Tissue / Q000737:chemistry; D000818:Animals; D002849:Chromatography, Gas; D004305:Dose-Response Relationship, Drug; D004563:Electrochemistry; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D007306:Insecticides / Q000032:analysis* / Q000097:blood; D008252:Macaca fascicularis; D008297:Male; D010573:Pesticide Residues / Q000032:analysis*; D010865:Pilot Projects; D014112:Toxaphene / Q000032:analysis* / Q000097:blood
D007306:Insecticides; D010573:Pesticide Residues; D014112:Toxaphene