The 1996 RSA Distinguished Research Award Lecture. A genetic animal model of alcohol withdrawal.
Work with genetic animal models has a long history in alcohol research. No attempt has been made here to acknowledge the contributions of the many other long-standing projects in the area. Rather, I have tried to give a capsule view of one such project, and to indicate some areas of future direction. It seems clear that the expression of molecular biological tools will greatly expand our capabilities in the immediate future. The field is well-situated to take advantage of this situation, as it has achieved much progress during the "dark ages," where the study of genetic influence was inferential: that is, we were limited to studying genes we could not identify. The future will surely lead us to the identification and study of specific genes of importance.
Crabbe
J C
JC
Research Service, Department of Veterans Affairs Medical Center, Portland, OR, USA.
D000430:Alcohol Withdrawal Delirium / Q000235:genetics*; D000437:Alcoholism / Q000235:genetics*; D000818:Animals; D001363:Awards and Prizes; D001921:Brain / Q000187:drug effects; D004195:Disease Models, Animal; D005544:Forecasting; D005819:Genetic Markers / Q000235:genetics; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics; D008957:Models, Genetic; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics; D012640:Seizures / Q000235:genetics; D012641:Selection, Genetic
D005819:Genetic Markers