title: [Functional electromyostimulation of the penile corpus cavernosum (FEMCC)]. Initial results of a new therapeutic option of erectile dysfunction].
abstract: Transcutaneous application of low-frequency electric current in the treatment of partially or temporarily denervated striated muscles is widely used to prevent or treat muscular atrophy. Due to the high regenerative capacity of smooth muscle cells, this approach should be beneficial in the treatment of diseases with smooth muscle degeneration due to partial denervation. Our study was done to evaluate the possible beneficial effect of transcutaneous application of low-frequency electric current to the corpus cavernosum penis in the treatment of erectile dysfunction. After a comprehensive work-up, 22 patients with chronic erectile dysfunction (21/22 vasoactive nonresponders) received daily (3-5 x 20 min) transcutaneous functional electromyostimulation of the corpus cavernosum smooth muscles (FEMCC; zero line symmetric impulses of trapezoid shape, two-channel device with alternating stimulations, f = 10-20 Hz for channel I and 20-35 Hz for channel II; t(i) = 100-2000 microseconds, approx. 12 mA, rise time 0.5 s, stimulation time 5 s per channel, interval between stimulations 0.5 s). Five of 22 patients (23%) regained full spontaneous erections and another three (14%) responded to vasoactive drugs after FEMCC. Fourteen were FEMCC failures, including two who subjectively 'improved'. In a similar group of patients evaluated during the same period but receiving no therapy, no spontaneous improvement of the erectile function was observed. Our preliminary results suggest that FEMCC is feasible and results in an improvement of the erectile capacity in a significant proportion (37%) of patients. Further studies will be carried out to corroborate our results, to improve stimulation parameters and to evaluate selection criteria for FEMCC.
authors.affiliation: Urologische Klinik, Hannover.
authors.forename: C G
authors.initials: CG
authors.lastname: Stief
authors.forename: E
authors.initials: E
authors.lastname: Weller
authors.forename: T
authors.initials: T
authors.lastname: Noack
authors.forename: M H
authors.initials: MH
authors.lastname: Djamilian
authors.forename: M
authors.initials: M
authors.lastname: Meschi
authors.forename: M
authors.initials: M
authors.lastname: Truss
authors.forename: U
authors.initials: U
authors.lastname: Jonas
mesh_terms: D000328:Adult; D004599:Electric Stimulation Therapy / Q000295:instrumentation*; D004576:Electromyography; D007172:Erectile Dysfunction / Q000503:physiopathology / Q000628:therapy*; D005500:Follow-Up Studies; D006801:Humans; D018783:Impotence, Vasculogenic / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology; D009121:Muscle Denervation; D009130:Muscle, Smooth / Q000294:innervation*; D009131:Muscle, Smooth, Vascular / Q000294:innervation; D009416:Nerve Regeneration / Q000502:physiology*; D010410:Penile Erection / Q000502:physiology*; D010413:Penis / Q000294:innervation*; D016896:Treatment Outcome