title: Six lignans from Phyllanthus myrtifolius.
abstract: Six lignans comprising phyllamyricins D (1), E (2), and F (3) and phyllamyricosides A (4), B (5), and C (6) were isolated in a continuing study of Phyllanthus myrtifolius. Compounds 1 and 2 are 2a-methoxy-4-aryl-2,3-naphthalides. Compounds 3-6 belong to the 4-arylnaphthalene class, with compounds 4-6 being O-beta-glucosides. Their structures were elucidated on the basis of spectral analysis. Compound 4 increased the activity of HIV-1 reverse transcriptase by 65% at a concentration of 1.89 microM.
authors.affiliation: School of Pharmacy, National Taiwan University, Taipei, Republic of China.
authors.forename: S S
authors.initials: SS
authors.lastname: Lee
authors.forename: M T
authors.initials: MT
authors.lastname: Lin
authors.forename: C L
authors.initials: CL
authors.lastname: Liu
authors.forename: Y Y
authors.initials: YY
authors.lastname: Lin
authors.forename: K C
authors.initials: KC
authors.lastname: Liu
mesh_terms: D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors*; D006801:Humans; D017705:Lignans / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D009281:Naphthalenes / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D017705:Lignans; D009281:Naphthalenes; D054303:HIV Reverse Transcriptase