title: Exercise induced sympathetic influences do not change interatrial conduction times in VDD and DDD pacing.
abstract: Using telemetry, right atrial electrogram (RA), and marker channel of atrial sense events (MA) in combination with the left atrial electrogram (LA), recorded by a filtered bipolar esophageal lead, interatrial conduction during submaximal exercise and at rest was examined in 46 DDD pacemaker patients. The RA-LA and MA-LA conduction times measured in the presence of atrial sensing (VDD) as well as the conduction time SA-LA from atrial stimulus (SA) to LA, determined during atrial pacing (DDD) were found to be individual constants independent of exercise induced sympathetic influences. Thus, having determined an optimal mechanical interval (LA-LV)mech/opt from left atrium to ventricle by other methods, the optimal AV delay for DDD as well as for VDD operation can be calculated by the sum of the appropriate interatrial conduction time (SA-LA, respectively MA-LA) and the (LA-LV)mech/opt interval. Due to the constant SA-LA and MA-LA, the difference between these two values (AV delay correction interval) is a constant as well, which remains unchanged during exercise. Therefore, in selecting the rate responsive AV delay, only hemodynamic and not electrophysiological measurements need to be considered.
authors.affiliation: University of Rostock, Clinic for Internal Medicine, Rostock, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Ismer
authors.forename: G H
authors.initials: GH
authors.lastname: Von Knorre
authors.forename: W
authors.initials: W
authors.lastname: Voss
authors.forename: W
authors.initials: W
authors.lastname: Grille
authors.forename: G
authors.initials: G
authors.lastname: Klenke
authors.forename: K
authors.initials: K
authors.lastname: Pulya
authors.forename: W
authors.initials: W
authors.lastname: Koglek
authors.forename: A
authors.initials: A
authors.lastname: Suntinger
authors.forename: H
authors.initials: H
authors.lastname: Luessow
mesh_terms: D000368:Aged; D016275:Atrial Function; D016279:Atrial Function, Left; D016280:Atrial Function, Right; D001283:Atrioventricular Node / Q000503:physiopathology; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D015716:Electrocardiography, Ambulatory / Q000295:instrumentation; D004594:Electrophysiology; D004947:Esophagus; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans; D008297:Male; D010138:Pacemaker, Artificial; D005082:Physical Exertion / Q000502:physiology*; D012146:Rest; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D013686:Telemetry; D013997:Time Factors; D016277:Ventricular Function, Left