title: Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction.
abstract: The human cytomegalovirus genome encodes proteins that trigger destruction of newly synthesized major histocompatibility complex (MHC) class I molecules. The human cytomegalovirus gene US2 specifies a product capable of dislocating MHC class I molecules from the endoplasmic reticulum to the cytosol and delivering them to the proteasome. This process involves the Sec61 complex, in what appears to be a reversal of the reaction by which it translocates nascent chains into the endoplasmic reticulum.
authors.affiliation: Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.
authors.forename: E J
authors.initials: EJ
authors.lastname: Wiertz
authors.forename: D
authors.initials: D
authors.lastname: Tortorella
authors.forename: M
authors.initials: M
authors.lastname: Bogyo
authors.forename: J
authors.initials: J
authors.lastname: Yu
authors.forename: W
authors.initials: W
authors.lastname: Mothes
authors.forename: T R
authors.initials: TR
authors.lastname: Jones
authors.forename: T A
authors.initials: TA
authors.lastname: Rapoport
authors.forename: H L
authors.initials: HL
authors.lastname: Ploegh
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D001693:Biological Transport, Active; D002460:Cell Line; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D003587:Cytomegalovirus / Q000276:immunology; D003600:Cytosol / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006031:Glycosylation; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D009097:Multienzyme Complexes / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex; D017510:Protein Folding; D000069816:SEC Translocation Channels; D014764:Viral Proteins / Q000276:immunology
chemical_list: D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins; D009097:Multienzyme Complexes; D000069816:SEC Translocation Channels; D014764:Viral Proteins; D000255:Adenosine Triphosphate; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex