ICE-like proteases execute the neuronal death program.
The past year has witnessed significant advances in our understanding of the mechanisms that kill neurons during programmed cell death. The executioners are members of a family of proteases founded by ced-3, the product of a gene that is required for programmed cell death in the nematode Caenorhabditis elegans, and by mammalian interleukin-1 beta-converting enzyme. These proteases represent interesting novel targets for the therapy of acute and chronic pathologies of the nervous system associated with neuronal death.
Martinou
J C
JC
Geneva Biomedical Research Institute, Glaxo Wellcome Research and Development S.A, Switzerland. jcm26619@ggr.co.uk
Sadoul
R
R
D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis; D001665:Binding Sites; D017173:Caenorhabditis elegans; D002154:Calpain / Q000378:metabolism; D020170:Caspase 1; D003546:Cysteine Endopeptidases / Q000737:chemistry / Q000378:metabolism*; D004789:Enzyme Activation; D008322:Mammals; D008959:Models, Neurological; D009097:Multienzyme Complexes / Q000378:metabolism; D009474:Neurons / Q000166:cytology* / Q000502:physiology*; D046988:Proteasome Endopeptidase Complex
D009097:Multienzyme Complexes; D002154:Calpain; D003546:Cysteine Endopeptidases; D020170:Caspase 1; D046988:Proteasome Endopeptidase Complex