Acute growth hormone injection reduced gastrointestinal and increased hepatic oleic acid oxidation in swine.
Gastrointestinal, hepatic, and hindleg oxidation of 3H-labelled oleic acid and 14C-labelled glucose based on arterial-venous differences in 3H2O and 14CO2 were studied before and after an intravenous injection of 24 IU of growth hormone in 10 piglets. Hepatic oleic acid oxidation increased transiently while gastrointestinal oleic acid oxidation decreased correspondingly, maintaining a constant splanchnic oleic acid oxidation. Administration of a growth hormone led to a transient, parallel decrease in both hepatic and gastrointestinal glucose oxidation. We conclude that, in contrast to the growth hormone effect on splanchnic glucose oxidation, growth hormone effect on splanchnic fat oxidation appears to be organ specific.
Unneberg
K
K
Institute of Clinical Medicine, University of Tromso, Norway.
Steigen
T
T
Revhaug
A
A
Larsen
T
T
Mjaaland
M
M
D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D004064:Digestive System / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D013006:Growth Hormone / Q000008:administration & dosage*; D007275:Injections, Intravenous; D008099:Liver / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism*; D019301:Oleic Acid / Q000378:metabolism*; D009928:Organ Specificity; D010084:Oxidation-Reduction; D013552:Swine
D019301:Oleic Acid; D013006:Growth Hormone; D005947:Glucose