title: [LGL lymphoma].
abstract: We reported in this article two patients with large granular lymphocytic lymphoma (abbreviated as LGL lymphoma). One was the patient with LGL leukemia/lymphoma (patient 1) and other was the patient with NK-LGL lymphoma (patient 2). Because the gene of TCR delta was rearranged in the patient 1, the clonality of the LGL leukemia/lymphoma was confirmed. However, it is not determined yet whether the lineage of tumor cells is T cells or NK cells. The cytochemical features of the lymphoma cells of the patient 2 were studied. It was found that NK cell-derived lymphoma cells of the patient were positively stained with these two monoclonal antibodies that are reactive with T cell; one is anti-CD45RO (UCHL-1) and other is anti-CD3. Judging from the result, malignant NK-LGL cells in some patients are cytoplasmic CD3+ and UCHl-1+. It is emphasized that May-Grünwald-Giemsa stain of biopsied specimen of the lymphoma is required for making the diagnosis of LGL lymphoma.
authors.affiliation: Department of Clinical Hematology, Osaka University Medical School.
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: S
authors.initials: S
authors.lastname: Tagawa
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authors.initials: K
authors.lastname: Koh
authors.forename: M
authors.initials: M
authors.lastname: Hino
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authors.lastname: Yamane
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authors.lastname: Wakasa
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authors.lastname: Sasaki
authors.forename: M
authors.initials: M
authors.lastname: Mizuki
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authors.initials: Y
authors.lastname: Azenishi
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
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authors.initials: T
authors.lastname: Machii
authors.forename: K
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authors.lastname: Aozasa
authors.forename: M
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authors.lastname: Ohsawa
authors.forename: Y
authors.initials: Y
authors.lastname: Sugano
authors.forename: J
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authors.lastname: Hara
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authors.lastname: Kawa
authors.forename: N
authors.initials: N
authors.lastname: Tatsumi
mesh_terms: D000328:Adult; D016694:Gene Rearrangement, delta-Chain T-Cell Antigen Receptor; D006801:Humans; D007244:Infectious Mononucleosis; D007694:Killer Cells, Natural; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000473:pathology