title: Expression of calbindin-D28K by reactive astrocytes in gerbil hippocampus after ischaemia.
abstract: Calbindin-D28K (Calbindin) is a member of the superfamily of calcium-binding proteins that is implicated in the regulation of intracellular calcium. In the adult mammalian brain, calbindin was thought to be present only in neurones, where it is believed to serve a neuroprotective role. We now report the expression of calbindin after ischaemia in reactive astrocytes in the CA1 subfield of the hippocampus. Since other calcium-binding proteins, such as S-100 and calmodulin, which induce transformation or proliferation of glia, occur in astrocytes, it is conceivable that the expression of calbindin after ischaemia might be an important part of the process of gliosis.
authors.affiliation: Department of Biology, Kagawa Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Toyoshima
authors.forename: S
authors.initials: S
authors.lastname: Yamagami
authors.forename: B Y
authors.initials: BY
authors.lastname: Ahmed
authors.forename: L
authors.initials: L
authors.lastname: Jin
authors.forename: O
authors.initials: O
authors.lastname: Miyamoto
authors.forename: T
authors.initials: T
authors.lastname: Itano
authors.forename: M
authors.initials: M
authors.lastname: Tokuda
authors.forename: H
authors.initials: H
authors.lastname: Matsui
authors.forename: O
authors.initials: O
authors.lastname: Hatase
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000378:metabolism* / Q000473:pathology; D064026:Calbindins; D005849:Gerbillinae; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism* / Q000473:pathology; D007150:Immunohistochemistry; D002546:Ischemic Attack, Transient / Q000378:metabolism* / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D017966:Pyramidal Cells / Q000166:cytology / Q000378:metabolism* / Q000473:pathology; D064030:S100 Calcium Binding Protein G / Q000032:analysis / Q000096:biosynthesis*; D013997:Time Factors
chemical_list: D064026:Calbindins; D005904:Glial Fibrillary Acidic Protein; D009419:Nerve Tissue Proteins; D064030:S100 Calcium Binding Protein G