The spindle assembly checkpoint.
The spindle assembly checkpoint monitors proper chromosome attachment to spindle microtubules and is conserved from yeast to humans. Checkpoint components reside on kinetochores of chromosomes and show changes in phosphorylation and localization as cells proceed through mitosis. Adaptation to prolonged checkpoint arrest can occur by inhibitory phosphorylation of Cdc2.
Rudner
A D
AD
Department of Physiology, Box 0444, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0444, USA. rudner@socrates.ucsf.edu
Murray
A W
AW
D002455:Cell Division / Q000502:physiology; D002477:Cells / Q000737:chemistry* / Q000166:cytology* / Q000201:enzymology; D008941:Spindle Apparatus / Q000737:chemistry* / Q000201:enzymology*