title: Acromegaly associated with Chiari-I malformation and polycystic ovary syndrome.
abstract: We report a 19-year-old female case of acromegaly associated with Chiari-I malformation and polycystic ovary syndrome. She also had syringomyelia and thoracic scoliosis. Although the association of acromegaly and Chiari-I malformation was by chance, exaggerated secretion of growth hormone may have aggravated the scoliosis. The incidence of polycystic ovary in acromegalic patients remains to be elucidated. However, elevation of plasma insulin and insulin-like growth factor, that is usually observed in patients with acromegaly, could stimulate androgen production in the ovaries. The patient was successfully treated with transsphenoidal adenomectomy for pituitary tumor and correction surgery for thoracic scoliosis.
authors.affiliation: Department of Geriatrics, Shinshu University School of Medicine, Matsumoto.
authors.forename: M
authors.initials: M
authors.lastname: Hara
authors.forename: K
authors.initials: K
authors.lastname: Ichikawa
authors.forename: K
authors.initials: K
authors.lastname: Minemura
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
authors.forename: N
authors.initials: N
authors.lastname: Suzuki
authors.forename: A
authors.initials: A
authors.lastname: Sakurai
authors.forename: Y
authors.initials: Y
authors.lastname: Nishii
authors.forename: K
authors.initials: K
authors.lastname: Hashizume
authors.forename: K
authors.initials: K
authors.lastname: Ohtsuka
mesh_terms: D000172:Acromegaly / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D000236:Adenoma / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D000328:Adult; D001139:Arnold-Chiari Malformation / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood; D008279:Magnetic Resonance Imaging; D010911:Pituitary Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D012600:Scoliosis / Q000150:complications / Q000175:diagnosis; D013595:Syringomyelia / Q000150:complications / Q000175:diagnosis; D013904:Thoracic Vertebrae; D014057:Tomography, X-Ray Computed
chemical_list: D007334:Insulin-Like Growth Factor I; D007986:Luteinizing Hormone; D013006:Growth Hormone