[The resorptive behavior of a low-molecular weight humic substance after a single oral administration to the rat].
By labeling HS 1500 with a radioactive 14C, it was proven that after oral application and under certain circumstances, low amounts of low molecular humic acids are for a short time absorbed from the gastrointestinal tract. But the biological availability of the substance is very low (less than 0.1% of the applied high doses). The plasma concentration curve assumes a first order kinetic for invasion and excretion. After oral application of 500 mg/kg b.w. HS 1500 the half life period was 1.5 hours and maximum plasma concentration was 3 micrograms/ml. The result obtained indicate that HS 1500 is toxicological riskless after oral administration. Taking into account the pharmacokinetic data, residues of the substance in animal tissues can be ruled out with high significance.
Lange
N
N
Institut für Pharmakologie, Pharmazie und Toxikologie der Veterinärmedizinischen Fakultät, Universität Leipzig.
Kühnert
M
M
Haase
A
A
Höke
H
H
Seubert
B
B
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D005260:Female; D006207:Half-Life; D006812:Humic Substances / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D007408:Intestinal Absorption; D008970:Molecular Weight; D051381:Rats; D017208:Rats, Wistar
D006812:Humic Substances