Mitochondria, free radicals, and neurodegeneration.
A central role for defective mitochondrial energy production, and the resulting increased levels of free radicals, in the pathogenesis of various neurodegenerative diseases is gaining increasing acceptance. Defects in energy metabolism may contribute to both excitotoxicity and oxidative damage. Evidence implicating energy defects in neurodegenerative diseases comes from similarities to known mitochondrial disorders, including delayed and variable age of onset, slow progression, and symmetric degeneration of circumscribed groups of neurons.
Beal
M F
MF
Neurochemistry Laboratory, Massachusetts General Hospital, Boston 02114, USA.
D000544:Alzheimer Disease / Q000378:metabolism; D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics / Q000378:metabolism; D000818:Animals; D016923:Cell Death; D004734:Energy Metabolism; D005609:Free Radicals; D006801:Humans; D006816:Huntington Disease / Q000235:genetics / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D017237:Mitochondrial Encephalomyopathies / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D009410:Nerve Degeneration; D009474:Neurons / Q000473:pathology; D018384:Oxidative Stress
D005609:Free Radicals