title: [Herpes simplex meningoencephalitis in an infant observed during an epidemic of enteroviral infections of the nervous system].
abstract: An infant with Herpes simplex meningoencephalitis which occurred during an epidemic of enteroviral neuroinfections is described. Clinical and laboratory signs of meningitis as well as preceding aphtous oropharyngeal inflammation, initially suggested an enteroviral etiology. The appearance of signs of encephalitis with focal neurologic disturbances and the results of brain imaging by computed tomography, primarily the detection of temporoparietal areas of hypodensity, raised the possibility of HSV infection. Thanks to early specific treatment with acyclovir, the infant recovered from meningoencephalitis and 4 months later presented only minor neurological sequelae (slight left hemiparesis). The diagnosis of Herpes simples meningoencephalitis was confirmed by detecting IgM and IgG anti-HSV antibodies in the serum and cerebrospinal fluid both at the beginning and after 10 days of treatment and also by a eightfold rise of the anti-HSV-1 antibody level in serum. The authors emphasize the role of brain imaging (computed tomography and magnetic resonance) in the differential diagnosis of viral nervous system infections and suggest early treatment with acyclovir in case of suspicion of HSV-encephalitis.
authors.affiliation: Katedra i Klinika Chorób Zakaznych Dzieci Akademii Medycznej we Wrocławiu.
authors.forename: Z
authors.initials: Z
authors.lastname: Szychowska
authors.forename: E
authors.initials: E
authors.lastname: Kuchar
authors.forename: M
authors.initials: M
authors.lastname: Sasiadek
mesh_terms: D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000134:cerebrospinal fluid; D007075:Immunoglobulin M / Q000097:blood / Q000134:cerebrospinal fluid; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D008590:Meningoencephalitis / Q000175:diagnosis / Q000821:virology*; D018139:Simplexvirus / Q000302:isolation & purification*; D014057:Tomography, X-Ray Computed
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M