title: Blockade by ginseng total saponin of methamphetamine-induced hyperactivity and conditioned place preference in mice.
abstract: Ginseng total saponin (GTS) inhibited methamphetamine-induced hyperactivity and conditioned place preference (CPP). Dopamine (DA) receptor supersensitivity was developed in methamphetamine-induced CPP mice and it was inhibited by GTS. GTS also inhibited apomorphine-induced climbing behavior, showing the antidopaminergic activity of GTS. These results suggest that GTS inhibition of the methamphetamine-induced hyperactivity and CPP may be closely related with the inhibition of dopaminergic activation induced by methamphetamine.
authors.affiliation: Department of Pharmacology, Chungbuk National University, Cheongju, Korea.
authors.forename: H S
authors.initials: HS
authors.lastname: Kim
authors.forename: C G
authors.initials: CG
authors.lastname: Jang
authors.forename: W K
authors.initials: WK
authors.lastname: Park
authors.forename: K W
authors.initials: KW
authors.lastname: Oh
authors.forename: H M
authors.initials: HM
authors.lastname: Rheu
authors.forename: D H
authors.initials: DH
authors.lastname: Cho
authors.forename: S
authors.initials: S
authors.lastname: Oh
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D000697:Central Nervous System Stimulants / Q000037:antagonists & inhibitors*; D018491:Dopamine Agonists / Q000494:pharmacology; D006702:Homing Behavior; D008297:Male; D008694:Methamphetamine / Q000037:antagonists & inhibitors*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D005894:Panax; D010946:Plants, Medicinal; D012503:Saponins / Q000494:pharmacology*
chemical_list: D000697:Central Nervous System Stimulants; D018491:Dopamine Agonists; D012503:Saponins; D008694:Methamphetamine; D001058:Apomorphine