Osteonecrosis of the femoral head in patients with inflammatory arthritis or asthma receiving corticosteroid therapy.
The utilization of corticosteroids in the management of acute and chronic inflammatory processes, such as asthma or inflammatory arthritis, has been implicated in the adverse effects of multiple organ systems. One potential area of these negative consequences in the use of corticosteroids is the development of osteonecrosis of the femoral head. A direct time/dosage relationship for treatment with corticosteroids of patients with an established diagnosis of asthma or inflammatory arthritis and femoral osteonecrosis is unknown. A prospective study was undertaken to evaluate the use of corticosteroids and the incidence of osteonecrosis of the femoral head and potentially establish a time/dosage relationship in this patient population. No direct relationship between corticosteroid dosage and the development of femoral head osteonecrosis in 1420 hip-years was demonstrated at 10-year follow up.
Colwell
C W
CW
Division of Orthopedic Surgery, Scripps Clinic and Research Foundation, La Jolla, Calif 92037, USA.
Robinson
C A
CA
Stevenson
D D
DD
Vint
V C
VC
Morris
B A
BA
D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy*; D001249:Asthma / Q000150:complications / Q000188:drug therapy*; D003710:Demography; D005260:Female; D005271:Femur Head Necrosis / Q000139:chemically induced* / Q000150:complications; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D000305:Adrenal Cortex Hormones