Effect of methyl linoleate hydroperoxides on murine natural killer cell-mediated cytotoxicity.
Methyl linoleate hydroperoxides (MLHPO), a model for lipid hydroperoxides, suppressed murine natural killer (NK) cell-mediated cytotoxicity to YAC-1 cells. When NK cells were cultured with MLHPO, the conjugation of NK cells could not lyse YAC-1 cells. These findings suggest that NK cell-mediated cytotoxicity can be suppressed by lipid hydroperoxides.
Oarada
M
M
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
Kurita
N
N
Terao
K
K
Miyaji
M
M
D000818:Animals; D002460:Cell Line; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology*; D008054:Lipid Peroxides / Q000494:pharmacology*; D008223:Lymphoma / Q000276:immunology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D013154:Spleen / Q000276:immunology; D014407:Tumor Cells, Cultured
D008054:Lipid Peroxides; C008464:methyl linoleate hydroperoxide