title: [Increased effectiveness of etiotropic therapy of experimental plague in albino mice at the stage of generalized infection].
abstract: Therapeutic efficacies of various drugs were studied comparatively in the treatment of experimental plague in albino mice at the stage of the infection generalization. It was shown that out of the tested drugs such as ciprofloxacin, amikacin, gentamicin, rifampicin and polymyxin B only ciprofloxacin provided a rather high therapeutic effect in the treatment of the plaque septic form. The in vitro and in vivo experiments demonstrated that ciprofloxacin had an antitoxic action on lipopolysaccharide (LPS) and the plague microbe toxin. In comparison to ciprofloxacin, polymyxin B had a higher neutralizing activity. It was found that the efficacy of the experimental plague treatment at the stage of the infection generalization increased with the use of combinations of the drugs with antitoxic and antibacterial activities (ciprofloxacin and polymyxin B).
authors.forename: V V
authors.initials: VV
authors.lastname: Ryzhkova
authors.forename: N V
authors.initials: NV
authors.lastname: Pavlovich
authors.forename: L N
authors.initials: LN
authors.lastname: Makarovskaia
authors.forename: V A
authors.initials: VA
authors.lastname: Zurabian
authors.forename: I A
authors.initials: IA
authors.lastname: Bespalova
authors.forename: E K
authors.initials: EK
authors.lastname: Goncharov
authors.forename: O K
authors.initials: OK
authors.lastname: Bugaeva
authors.forename: N N
authors.initials: NN
authors.lastname: Malsova
mesh_terms: D000583:Amikacin / Q000627:therapeutic use; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000627:therapeutic use; D018450:Disease Progression; D004353:Drug Evaluation, Preclinical; D005839:Gentamicins / Q000627:therapeutic use; D051379:Mice; D010930:Plague / Q000188:drug therapy* / Q000473:pathology; D011113:Polymyxins / Q000627:therapeutic use; D012293:Rifampin / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D005839:Gentamicins; D011113:Polymyxins; D002939:Ciprofloxacin; D000583:Amikacin; D012293:Rifampin