1,2,3-Triazolo [4,5-d] pyridazines--V. Preparation and adenosine receptor binding of new 4-amino derivatives.
This paper reports the continuation of studies on the 4-aminosubstituted 1,2,3-triazolo [4,5-d] pyridazine derivatives which had shown binding affinity towards A1-adenosine receptors. 1-Benzyl derivatives bearing new amines and new 1-(substituted benzyl) derivatives were prepared and tested. The biological results showed that some compounds possessed high affinity (approximately 30-70 nM) and good selectivity toward the A1-adenosine receptors. Further information about structure-biological activity relationships was aquired.
Biagi
G
G
Dipartimento di Scienze Farmaceutiche, Facoltà di Farmacia, Università di Pisa.
Giorgi
I
I
Livi
O
O
Manera
C
C
Scartoni
V
V
Lucacchini
A
A
Senatore
G
G
D000818:Animals; D011724:Pyridazines / Q000138:chemical synthesis* / Q000378:metabolism; D051381:Rats; D018047:Receptors, Purinergic P1 / Q000378:metabolism*; D012756:Sheep; D013329:Structure-Activity Relationship
D011724:Pyridazines; D018047:Receptors, Purinergic P1