[The effect of calcium antagonist on ischemia-reperfusion injury of the rabbit retina].
We investigated the effect of nicardipine (NC), a calcium antagonist, on retinal ischemia-reperfusion injury. Electroretinogram (ERG) was recorded from rabbit eyes before and after ischemia produced by increasing intraocular pressure to 140 mmHg for 90 min after giving 0.01% NC (0.1 ml) intravitreally (n = 4). ERGs from intact (non-ischemic) rabbit eyes after injecting NC intravitreally was also recorded (n = 4) (NC group). The recovery rate of b-wave amplitude after reperfusion was significantly higher in the NC group than in the control group which was given saline without NC (p < 0.05). There were no significant differences between the NC and the control groups in a-wave amplitude and implicit time of the b-wave. No significant changes were detected in the a-wave or b-wave amplitude after intravitreal injection of NC into the intact eyes. We suggest that NC can prevent ischemia-reperfusion injury of the rabbit retina and could be considered for clinical use.
Mori
T
T
Department of Ophtkalmology, Iwate Prefectural Central Hospital, Japan.
Sugawara
T
T
Hosobe
Y
Y
Gotoh
T
T
Kato
C
C
Tazawa
Y
Y
D000818:Animals; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004596:Electroretinography; D007511:Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D009529:Nicardipine / Q000627:therapeutic use*; D011817:Rabbits; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000503:physiopathology; D012164:Retinal Diseases / Q000188:drug therapy / Q000503:physiopathology; D012171:Retinal Vessels
D002121:Calcium Channel Blockers; D009529:Nicardipine