title: Pruritus and skin hydration during dialysis.
abstract: BACKGROUND
  Dry skin is frequently observed in uraemic patients and a link with the common complaint of pruritus has been suggested. Objective data on skin dryness in haemodialysed patients is sparse and equivocal. No such information exists for the many patients now receiving peritoneal dialysis. We assessed the prevalence and severity of both pruritus and skin dryness in a uraemic population receiving maintenance dialysis.
  
  
  METHODS
  Forty-eight haemodialysis and 24 peritoneal dialysis patients were examined and skin dryness assessed by clinical grading and measurement of stratum corneum hydration using a corneometer. Forty age- and sex-matched controls were also assessed. Several biochemical parameters with possible relevance to pruritus were measured. Regular emollient therapy was prescribed to pruritic dialysis patients and efficacy assessed.
  
  
  RESULTS
  Dialysis patients overall had clinically drier skin than controls, especially the peritoneal dialysis group. Stratum corneum hydration levels were significantly reduced in the peritoneal dialysis (P < 0.004), but not the haemodialysis, population. Twenty-seven per cent of haemodialysed and 54% of peritoneal dialysis patients complained of pruritus. Pruritic patients in each dialysis group had significantly lower hydration than non-pruritic patients (P < 0.05). Regular emollient use in pruritic patients produced a marked reduction in severity of pruritus, abolishing the symptom in nine of 21 patients treated.
  
  
  CONCLUSIONS
  Reduced stratum corneum hydration correlates with pruritus in patients on maintenance haemodialysis and peritoneal dialysis, and may be alleviated by simple emollient therapy.
authors.affiliation: Department of Dermatology, Ninewells Hospital, Dundee, Scotland, UK.
authors.forename: C A
authors.initials: CA
authors.lastname: Morton
authors.forename: M
authors.initials: M
authors.lastname: Lafferty
authors.forename: C
authors.initials: C
authors.lastname: Hau
authors.forename: I
authors.initials: I
authors.lastname: Henderson
authors.forename: M
authors.initials: M
authors.lastname: Jones
authors.forename: J G
authors.initials: JG
authors.lastname: Lowe
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D004643:Emollients / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D011537:Pruritus / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D006435:Renal Dialysis / Q000009:adverse effects*; D012867:Skin / Q000187:drug effects / Q000378:metabolism*; D014867:Water / Q000378:metabolism
chemical_list: D004643:Emollients; D014867:Water