Integrins and cancer.
The past year or two has seen great advances in the elucidation of significant roles for integrins in cancer cells. These include roles in signal transduction, gene expression, proliferation, apoptosis regulation, invasion and metastasis, and angiogenesis. In particular, integrin alphavbeta3 has been implicated in the neovascularization of tumors. In addition, this integrin has been shown to contribute to the survival, proliferation and metastatic phenotype of human melanoma.
Varner
J A
JA
Department of Medicine, University of California, San Diego, University Center 303, 9500 Gilman Drive, La Jolla, CA 92093-0063, USA. jvarner@ucsd.edu
Cheresh
D A
DA
D000818:Animals; D017209:Apoptosis; D002455:Cell Division; D002465:Cell Movement; D006801:Humans; D016023:Integrins / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*; D009389:Neovascularization, Pathologic / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*
D016023:Integrins