[Intracytoplasmic sperm injection and Klinefelter syndrome].
Sperm cytogenetic study in two patients with Klinefelter's syndrome have demonstrated that there existed a risk low but highly significant, to transmit a sex chromosome abnormality to the offsprings. This result argues for a systematic karyotype before ICSI, and if such mosaïcs can be treated by ICSI, they must be firstly associated to a genetic counselling.
Sèle
B
B
Equipe de Biologie de la Reproduction, INSERM U 309, Institut Albert Bonniot, Faculté de Médecine de Grenoble, La Tronche.
Cozzi
J
J
Chevret
E
E
Monteil
M
M
Rousseaux
S
S
Pelletier
R
R
D005307:Fertilization in Vitro / Q000009:adverse effects*; D005817:Genetic Counseling; D005820:Genetic Testing; D006801:Humans; D007621:Karyotyping; D007713:Klinefelter Syndrome / Q000235:genetics* / Q000517:prevention & control; D008297:Male; D008845:Microinjections / Q000009:adverse effects*; D009030:Mosaicism; D012307:Risk Factors; D013094:Spermatozoa