Tolerance to intravenous administration of heparin and heparinoid in a patient with delayed-type hypersensitivity to heparins and heparinoids.
Delayed-type hypersensitivity reactions to subcutaneously (s.c.) injected heparins are common. Since similar reactions usually occur to different heparin preparations, semisynthetic heparinoids might be a therapeutic alternative. We report a patient exhibiting eczematous reactions to heparins as well as heparinoids; delayed-type hypersensitivity was demonstrated by intracutaneous (i.c.) and patch tests, as well as by s.c. provocation. Remarkably, intravenous (i.v.) administration of heparin as well as heparinoid was well-tolerated.
Boehncke
W H
WH
Department of Dermatology, University of Ulm, Germany.
Weber
L
L
Gall
H
H
D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000209:etiology* / Q000517:prevention & control; D003875:Drug Eruptions / Q000209:etiology* / Q000517:prevention & control; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects*; D006496:Heparinoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007262:Infusions, Intravenous; D007279:Injections, Subcutaneous; D008875:Middle Aged
D000925:Anticoagulants; D006496:Heparinoids; D006493:Heparin