title: Trichinella infection and clinical disease.
abstract: Trichinellosis is caused by ingestion of insufficiently cooked meat contaminated with infective larvae of Trichinella species. The clinical course is highly variable, ranging from no apparent infection to severe and even fatal disease. We report two illustrative cases of trichinellosis. Returning to Denmark a few days after having eaten roasted pork in the Republic of Serbia, a female patient suffered from severe vomiting, epigastric pain, diarrhoea, and later myalgia, arthralgia, generalized oedema, and prostration. A biopsy showed heavy infestation with Trichinella spiralis, 2000 larvae/g of muscle. Life-threatening cardiopulmonary, renal and central nervous system complications developed. The patient recovered after several months. Her husband, who also ate the pork, did not have clinical symptoms, but an increased eosinophil count and a single larva in a muscle biopsy confirmed infection. The epidemiology, clinical manifestations, diagnosis, treatment and prevention of trichinellosis are reviewed.
authors.affiliation: Department of Infectious Diseases, University of Copenhagen, Denmark.
authors.forename: M R
authors.initials: MR
authors.lastname: Clausen
authors.forename: C N
authors.initials: CN
authors.lastname: Meyer
authors.forename: T
authors.initials: T
authors.lastname: Krantz
authors.forename: C
authors.initials: C
authors.lastname: Moser
authors.forename: G
authors.initials: G
authors.lastname: Gomme
authors.forename: L
authors.initials: L
authors.lastname: Kayser
authors.forename: J
authors.initials: J
authors.lastname: Albrectsen
authors.forename: C M
authors.initials: CM
authors.lastname: Kapel
authors.forename: I C
authors.initials: IC
authors.lastname: Bygbjerg
mesh_terms: D000818:Animals; D000969:Antinematodal Agents; D005260:Female; D006801:Humans; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000469:parasitology*; D017160:Trichinella spiralis; D014235:Trichinellosis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*
chemical_list: D000969:Antinematodal Agents