Apoptosis: telling cells their time is up.
Ligand engagement by the receptor Fas leads to apoptosis. A clue to how this happens comes from the discovery that ligand binding leads to recruitment to Fas of a protease, homologous to interleukin-1 beta converting enzyme, likely to initiate a proteolytic cascade that drives apoptosis.
Nagata
S
S
Department of Genetics, Osaka University Medical School, Japan.
D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D017173:Caenorhabditis elegans; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D053222:Fas Ligand Protein; D008024:Ligands; D008562:Membrane Glycoproteins / Q000378:metabolism; D008969:Molecular Sequence Data; D019014:fas Receptor / Q000378:metabolism
D053222:Fas Ligand Protein; D008024:Ligands; D008562:Membrane Glycoproteins; D019014:fas Receptor; D003546:Cysteine Endopeptidases