Dietary fish oil and blood lipids.
Triglyceride lowering is the most consistent effect of fish oils, having been observed in Greenland Eskimos and subsequently in controlled clinical trials. Although total cholesterol levels are not altered, LDL levels may rise, especially in hypertriglyceridemic patients. The persistence of the hypotriglyceridemic effect has been documented in two recent trials following large numbers of patients from 6-9 months. These studies also provided evidence that the LDL raising effect may not persist. The safety of fish oils was also supported in these studies because problems with excessive bleeding and worsening glycemic control did not materialize. However, in one of these studies fish oils proved ineffective in slowing the rate of restenosis after coronary angioplasty.
Harris
W S
WS
Lipoprotein and Nutrition Research Laboratory, University of Kansas Medical Center, Kansas City 66160-7418, USA.
D015906:Angioplasty, Balloon, Coronary; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000178:diet therapy / Q000517:prevention & control; D003920:Diabetes Mellitus / Q000178:diet therapy; D004041:Dietary Fats / Q000009:adverse effects / Q000494:pharmacology*; D015525:Fatty Acids, Omega-3 / Q000009:adverse effects / Q000494:pharmacology; D005395:Fish Oils / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D014280:Triglycerides / Q000097:blood
D004041:Dietary Fats; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D014280:Triglycerides