title: HCV liver disease in renal transplantation: a clinical and histological study.
abstract: The prevalence of HCV infection is high in renal transplantation (RT) patients: 29% in our cohort of 399 RT recipients. The consequences of that infection on the liver have to be carefully assessed. Clinical chronic hepatitis was detected from ALT concentrations (> x 1.5 N) in only 26 patients (22%) with constant (15%) or fluctuating (85%) ALT elevation. Only three of 117 cases developed cirrhosis (3%). No liver cancer was noted. Liver biopsy was performed (mean interval = 60.2 months) in 62 patients with HCV infection alone. We found 26 cases (42%) of chronic active hepatitis (CAH) with a mean Knodell score as low as 6.1 (range: 3-12), a mean activity grade of 4.9, and a fibrosis stage of 1.3. Twelve patients (19%) presented with normal liver pathology and met the criteria of healthy HCV carriers (positive viraemia, normal ALT and normal liver). The rest presented with portal lesions, either inflammation or fibrosis. In addition, patient and graft survival rates did not differ in HCV+ recipients. To conclude, HCV infection did not appear too deleterious for the liver in this cohort of patients. There is therefore no contraindication for HCV-positive recipients to undergo renal transplantation.
authors.affiliation: Department of Nephrology-Dialysis-Transplantation (NDT), Hôpital Nord, Saint-Etienne, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Haem
authors.forename: P
authors.initials: P
authors.lastname: Berthoux
authors.forename: S
authors.initials: S
authors.lastname: Cécillon
authors.forename: J F
authors.initials: JF
authors.lastname: Mosnier
authors.forename: B
authors.initials: B
authors.lastname: Pozzetto
authors.forename: F
authors.initials: F
authors.lastname: Berthoux
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood*; D000914:Antibodies, Viral / Q000032:analysis; D001706:Biopsy; D002648:Child; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000453:epidemiology / Q000276:immunology; D006085:Graft Survival; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology; D006526:Hepatitis C / Q000453:epidemiology / Q000276:immunology / Q000473:pathology*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012367:RNA, Viral / Q000032:analysis; D011863:Radioimmunoassay; D012189:Retrospective Studies
chemical_list: D000914:Antibodies, Viral; D012367:RNA, Viral; D000410:Alanine Transaminase