title: Mechanical circulatory support for post cardiotomy cardiogenic shock in infants.
abstract: Eleven infants weighing 2.3 to 7.8 kg underwent mechanical circulatory support for post cardiotomy cardiogenic shock. Initiated pre-operatively in two patients, extracorporeal membrane oxygenation was used in a total of eight patients aged 6 days to 3 months in association with repair of cyanotic congenital heart disease with increased pulmonary blood flow or with a right sided obstructive lesion. Ventricular assist devices were used in three other patients: a centrifugal left ventricular assist device in Patient 1 (10 months, 5.7 kg) after repair of the anomalous left coronary artery, and a pneumatic biventricular assist device (stroke volume 12 ml) in Patient 2 (6 months, 7.0 kg) for cardiac arrest after closure of ventricular septal defect and in Patient 3 (10 months, 7.8 kg) for post transplant graft failure. Duration of extracorporeal membrane oxygenation duration ranged from 26 to 192 hr (mean, 88 hr). Three patients were weaned from extracorporeal membrane oxygenation and two survived. Two others were separated from extracorporeal membrane oxygenation because of bleeding, but both subsequently died. Patient 1 was weaned from the left ventricular assist device after 192 hr and discharged from the hospital. Support was discontinued after 45 hr in Patient 2 who exhibited irreversible brain damage. Patient 3 was weaned from a biventricular assist device after 174 hr, but suffered recurrent graft failure. Our results show that an appropriate circulatory support system should be selected according to the cardiac anatomy in infants.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, German Heart Institute Berlin, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Ishino
authors.forename: V
authors.initials: V
authors.lastname: Alexi-Meskishvili
authors.forename: Y
authors.initials: Y
authors.lastname: Weng
authors.forename: M
authors.initials: M
authors.lastname: Loebe
authors.forename: F
authors.initials: F
authors.lastname: Uhlemann
authors.forename: P E
authors.initials: PE
authors.lastname: Lange
authors.forename: R
authors.initials: R
authors.lastname: Hetzer
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology; D001243:Assisted Circulation / Q000009:adverse effects / Q000379:methods*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D004867:Equipment Design; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects; D006353:Heart-Assist Devices / Q000009:adverse effects; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D012770:Shock, Cardiogenic / Q000209:etiology* / Q000601:surgery / Q000628:therapy*; D013997:Time Factors