Intravenous gamma globulin in refractory thrombotic thrombocytopenic purpura.
We report the case of a young woman with refractory thrombotic thrombocytopenic purpura (TTP), treated with different therapies (standard therapy with plasma exchange, prostacyclin infusion, vincristine sulfate) and responding to these for brief periods. High-dose immunoglobulin (400 mg/kg/day for 5 days), on the other hand, yielded a complete response which has lasted for 14 months up to the time of this report.
Nosari
A
A
Department of Hematology, Niguarda Cà Granda Hospital, Milan, Italy.
Muti
G
G
Busnach
G
G
Cantoni
S
S
Strinchini
A
A
Morra
E
E
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D011464:Epoprostenol / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D010951:Plasma Exchange; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D011241:Prednisone / Q000627:therapeutic use; D011697:Purpura, Thrombotic Thrombocytopenic / Q000628:therapy*; D012720:Severity of Illness Index; D016896:Treatment Outcome; D005719:gamma-Globulins / Q000008:administration & dosage*
D000893:Anti-Inflammatory Agents; D010975:Platelet Aggregation Inhibitors; D005719:gamma-Globulins; D011464:Epoprostenol; D011241:Prednisone