title: Dense microspheres in normal horse brain.
abstract: Here were report eosinophilic globular bodies referred to as dense microspheres (DMS), in the brains of normal horse in relation to the ageing process. The characteristic structures of DMS found in the horse were in similar to those previously reported in the human. The DMS were found predominantly in the neuropil of the cerebral cortex, and were shown histochemically to have a proteinaceous content. Electron microscopy showed that the DMS consisted of homogeneous electron-dense material bound by a single membrane and that they were found within the neuronal processes. In addition, immature or small DMS were observed, which seemed to be closely correlated with the endoplasmic reticulum.
authors.affiliation: Department of Veterinary Pathology, Obihiro University of Agriculture and Veterinary Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Furuoka
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: K
authors.initials: K
authors.lastname: Miyazawa
authors.forename: H
authors.initials: H
authors.lastname: Taniyama
authors.forename: T
authors.initials: T
authors.lastname: Matsui
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000648:ultrastructure; D005260:Female; D006736:Horses; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D008863:Microspheres; D009474:Neurons / Q000378:metabolism