Serum 3 alpha-androstanediol-glucuronide is decreased in nonhirsute women with acne vulgaris.
OBJECTIVE
To determine if acne vulgaris in women has a different pattern of androgen activity than hirsutism at the pilosebaceous unit.


METHODS
Prospective clinical study.


METHODS
Outpatient clinic for gynecological endocrinology at a university hospital.


METHODS
Twenty women suffering from mild or moderate acne vulgaris compared with 38 controls.


METHODS
Serum androgens DHEAS, androstendione, T, including 3 alpha-androstanediol-glucuronide (3 alpha-diolG), the metabolite of 5 alpha-reductase activity.


RESULTS
Serum 3 alpha-diolG was decreased in the acne groups depending on the grade of severity. No statistically significant differences were observed between the other androgens measured in acne patients and controls.


CONCLUSIONS
In contrast to hirsutism, acne is influenced directly by T and not by its 5 alpha-reduced metabolites. In female acne patients, 5 alpha-reductase activity appears to be reduced, which is reflected in decreased serum levels of 3 alpha-diolG. Consequently, 5 alpha-reductase inhibitors are most likely not promising candidates for acne therapy; a postulation that, however, requires further clinical investigation.
Joura
E A
EA
Department of Gynecology and Obstetrics, University of Vienna Medical School, General Hospital (AKH), Austria.
Geusau
A
A
Schneider
B
B
Söregi
G
G
Huber
J C
JC
D000152:Acne Vulgaris / Q000097:blood*; D000293:Adolescent; D000328:Adult; D015113:Androstane-3,17-diol / Q000031:analogs & derivatives* / Q000097:blood; D000735:Androstenedione / Q000097:blood; D003687:Dehydroepiandrosterone / Q000097:blood; D005260:Female; D006801:Humans; D011446:Prospective Studies; D013739:Testosterone / Q000097:blood
D015113:Androstane-3,17-diol; C028895:androstane-3,17-diol glucuronide; D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone