Enzymic lipid peroxidation--a consequence of cell injury?
It is postulated that cell injury activates "dormant" enzymes to produce lipid hydroperoxides. In a first step, membrane lipids are cleaved by esterases. The unsaturated fatty acids thus produced are converted in a second step by lipoxygenases to lipid hydroperoxides (LOOHs). In a third, nonenzymic step, these LOOHs, together with dienoic hydroxy fatty acids produced by enzymic reduction of LOOHs, react with a second oxygen molecule to generate dihydroperoxy-fatty acids and hydroxy-hydroperoxy-fatty acids, which are degraded to alpha-hydroxyladehydic compounds. This last reaction requires production of LO'-radicals by iron ions that also are generated as a result of cell damage. In addition, alpha-hydroxyaldehydes are produced by hydrolysis of plasmalogen epoxides, which are generated by oxidation of plasmalogens with LOO' or by action of epoxidases. We hypothize that alpha-hydroxyaldehydes act as second messengers. The release of lipoxygenase and the consequent lipid hydroperoxidation is postulated to occur in massive cell damage (e.g., myocardial infarction), in chronic diseases such as rheumatism, diabetes and atherosclerosis, in aging, and in control of cell proliferation.
Spiteller
G
G
Lehrstuhl Organische Chemie I, Universität Bayreuth, Germany.
D000375:Aging / Q000502:physiology; D000447:Aldehydes / Q000378:metabolism; D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D005075:Biological Evolution; D004789:Enzyme Activation / Q000502:physiology; D004852:Epoxy Compounds / Q000378:metabolism; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000378:metabolism; D008084:Lipoxygenase / Q000235:genetics; D008563:Membrane Lipids / Q000378:metabolism; D009203:Myocardial Infarction / Q000378:metabolism; D010955:Plasmalogens / Q000378:metabolism; D013552:Swine
D000447:Aldehydes; D004852:Epoxy Compounds; D008054:Lipid Peroxides; D008563:Membrane Lipids; D010955:Plasmalogens; D016718:Arachidonic Acid; D008084:Lipoxygenase