title: Estrogenicity of resin-based composites and sealants used in dentistry.
abstract: We tested some resin-based composites used in dentistry for their estrogenic activity. A sealant based on bisphenol-A diglycidylether methacrylate (bis-GMA) increased cell yields, progesterone receptor expression, and pS2 secretion in human estrogen-target, serum-sensitive MCF7 breast cancer cells. Estrogenicity was due to bisphenol-A and bisphenol-A dimethacrylate, monomers found in the base paste of the dental sealant and identified by mass spectrometry. Samples of saliva from 18 subjects treated with 50 mg of a bis-GMA-based sealant applied on their molars were collected 1 hr before and after treatment. Bisphenol-A (range 90-931 micrograms) was identified only in saliva collected during a 1-hr period after treatment. The use of bis-GMA-based resins in dentistry, and particularly the use of sealants in children, appears to contribute to human exposure to xenoestrogens.
authors.affiliation: Department of Radiology, Dentistry, and Department of Nutrition, School of Pharmacy, University of Granada, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Olea
authors.forename: R
authors.initials: R
authors.lastname: Pulgar
authors.forename: P
authors.initials: P
authors.lastname: Pérez
authors.forename: F
authors.initials: F
authors.lastname: Olea-Serrano
authors.forename: A
authors.initials: A
authors.lastname: Rivas
authors.forename: A
authors.initials: A
authors.lastname: Novillo-Fertrell
authors.forename: V
authors.initials: V
authors.lastname: Pedraza
authors.forename: A M
authors.initials: AM
authors.lastname: Soto
authors.forename: C
authors.initials: C
authors.lastname: Sonnenschein
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds; D017438:Bisphenol A-Glycidyl Methacrylate / Q000378:metabolism / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000378:metabolism*; D002455:Cell Division; D005260:Female; D006801:Humans; D008297:Male; D010636:Phenols / Q000378:metabolism / Q000494:pharmacology*; D010895:Pit and Fissure Sealants / Q000494:pharmacology*; D011960:Receptors, Estrogen / Q000819:agonists* / Q000378:metabolism; D011980:Receptors, Progesterone / Q000096:biosynthesis; D012463:Saliva / Q000737:chemistry; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D017438:Bisphenol A-Glycidyl Methacrylate; D010636:Phenols; D010895:Pit and Fissure Sealants; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C006780:bisphenol A; D000098826:Bisphenol A Compounds