High-fat, high-cholesterol diet raises plasma HDL cholesterol: studies on the mechanism of this effect.
Earlier work with human subjects showed that a low-fat, low-cholesterol diet lowered plasma high-density-lipoprotein-cholesterol (HDL-C) and the production rate of apolipoprotein A-I (apo A-I). More recent research with transgenic mice demonstrated that a high-fat, high-cholesterol diet raised plasma HDL-C and the production rate of apo A-I by a mechanism involving the regulation of translation of the apo A-I mRNA. The authors conclude that the rise induced in HDL-C by a high-fat, high-cholesterol diet is defensive and therefore, should not be interpreted as a desirable dietary change.
Wolf
G
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Department of Nutritional Sciences University of California, Berkeley 94720-3104, USA.
D016632:Apolipoprotein A-I / Q000235:genetics / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000494:pharmacology*; D008076:Cholesterol, HDL / Q000097:blood*; D004041:Dietary Fats / Q000494:pharmacology*; D006801:Humans; D012333:RNA, Messenger / Q000235:genetics
D016632:Apolipoprotein A-I; D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D004041:Dietary Fats; D012333:RNA, Messenger