Inhaled [13N]nitric oxide: a positron emission tomography (PET) study.
Using positron emission tomography (PET) and nitric oxide radiolabeled with nitrogen-13 (half-life 9.97 min) we probed the distribution and kinetics of inhaled nitric oxide in anesthetized dogs. The washout of this gas after inhalation was much slower than that observed for [13N]nitrogen gas, demonstrating its uptake by lung tissue. The small fraction of radioactivity found in the plasma was determined to be in the form of [13N]nitrate. The administered gas contained < 1 ppm of nonradioactive nitric oxide, which is believed to be below the physiologic threshold for vasorelaxation.
McCarthy
T J
TJ
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. mccarthy@mirlink.wustl.edu
Dence
C S
CS
Holmberg
S W
SW
Markham
J
J
Schuster
D P
DP
Welch
M J
MJ
D000280:Administration, Inhalation; D000818:Animals; D004285:Dogs; D007553:Isotope Labeling; D008168:Lung / Q000378:metabolism; D009569:Nitric Oxide / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D009584:Nitrogen / Q000378:metabolism; D009590:Nitrogen Radioisotopes / Q000737:chemistry; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
D009590:Nitrogen Radioisotopes; D009569:Nitric Oxide; D009584:Nitrogen