title: Epstein-Barr virus and human T-cell lymphomas.
abstract: Epstein-Barr virus has been classically associated with certain B-lymphocytic benign and malignant proliferations. However, using molecular biological techniques it becomes clear that EBV is also associated with several T-NHL in non-immunocompromised patients. The distribution of EBV-associated T-NHL seems to be site-restricted, i.e. in about 100% of the nasal T-NHL and in 20% of the lung and gastrointestinal lymphomas and rarely in primary cutaneous T-cell lymphomas. Moreover, the expression of the LMP1 protein seems to be associated with a poor prognosis. In this section the role of EBV in the pathogenesis of T-NHL will be discussed.
authors.affiliation: Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: C J
authors.initials: CJ
authors.lastname: Meijer
authors.forename: N M
authors.initials: NM
authors.lastname: Jiwa
authors.forename: D F
authors.initials: DF
authors.lastname: Dukers
authors.forename: J J
authors.initials: JJ
authors.lastname: Oudejans
authors.forename: P C
authors.initials: PC
authors.lastname: de Bruin
authors.forename: J M
authors.initials: JM
authors.lastname: Walboomers
authors.forename: A J
authors.initials: AJ
authors.lastname: van den Brule
mesh_terms: D005770:Gastrointestinal Neoplasms / Q000821:virology; D006566:Herpesviridae Infections; D004854:Herpesvirus 4, Human / Q000472:pathogenicity; D006801:Humans; D008175:Lung Neoplasms / Q000821:virology; D016399:Lymphoma, T-Cell / Q000821:virology*; D016410:Lymphoma, T-Cell, Cutaneous / Q000821:virology; D009669:Nose Neoplasms / Q000821:virology; D009693:Nucleic Acid Hybridization / Q000379:methods; D014412:Tumor Virus Infections