Vascularized nerve grafts. A review.
The attempts to reconstruct a transected trunk nerve with a free nerve graft of equal diameter have been hindered by the problem of delayed establishment of blood supply to the nerve graft and development eventually of central necrosis and finally failure of nerve regeneration. The transfer of a nerve graft which maintains its blood supply through its vascular pedicle that is microsurgically anastomosed to the recipient site vessels, provided the reconstructive microsurgeon with a new perspective to the clinical problem. A vascularized nerve graft diminishes endoneurial scarring by maintaining the Schwann cell population and decreasing fibroblast infiltration providing, thus, an optimal nutritional environment that results in an increased rate of axonal regeneration.
Terzis
J K
JK
Plastic and Reconstructive Surgery, Department of Surgery, Division of Plastic Surgery, Eastern Virginia Medical School, Norfolk, VA, USA.
Skoulis
T G
TG
Soucacos
P N
PN
D000328:Adult; D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D001158:Arteries / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008866:Microsurgery / Q000379:methods*; D010525:Peripheral Nerves / Q000098:blood supply / Q000637:transplantation*; D051381:Rats; D009435:Synaptic Transmission / Q000502:physiology; D016896:Treatment Outcome