title: [Amiodarone and thyroid: pharmacologic and toxic effects].
abstract: Amiodarone increases free T4, decreases free T3 and transiently increases TSH, that sometimes becomes undetectable. Amiodarone may induce: a) hypothyroidism, diagnosed by low free T4 and treated by l-thyroxine; b) thyrotoxicosis, diagnosed by high total or free T3, and some times requiring perchlorate, corticoids, plasmapheresis and thyroidectomy. Dysthyroidism is excluded by a normal TSH level, controlled twice a year.
authors.affiliation: Service de Médecine Interne, Clinique César De Paepe 2000, Bruxelles.
authors.forename: J
authors.initials: J
authors.lastname: Unger
mesh_terms: D000638:Amiodarone / Q000494:pharmacology* / Q000633:toxicity; D016903:Drug Monitoring; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism; D013963:Thyroid Hormones / Q000097:blood; D013971:Thyrotoxicosis / Q000139:chemically induced; D013972:Thyrotropin / Q000097:blood
chemical_list: D013963:Thyroid Hormones; D013972:Thyrotropin; D000638:Amiodarone