title: Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism.
abstract: The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism (Ames dwarf, df) has been positionally cloned, identifying a novel, tissue-specific, paired-like homeodomain transcription factor, termed Prophet of Pit-1 (Prop-1). The df phenotype results from an apparent failure of initial determination of the Pit-1 lineage required for production of growth hormone, prolactin or thyroid-stimulating hormone, resulting in dysmorphogenesis and failure to activate Pit-1 gene expression. These results imply that a cascade of tissue-specific regulators is responsible for the determination and differentiation of specific cell lineages in pituitary organogenesis.
authors.affiliation: Howard Hughes Medical Institute, University of California at San Diego, La Jolla 92093, USA.
authors.forename: M W
authors.initials: MW
authors.lastname: Sornson
authors.forename: W
authors.initials: W
authors.lastname: Wu
authors.forename: J S
authors.initials: JS
authors.lastname: Dasen
authors.forename: S E
authors.initials: SE
authors.lastname: Flynn
authors.forename: D J
authors.initials: DJ
authors.lastname: Norman
authors.forename: S M
authors.initials: SM
authors.lastname: O'Connell
authors.forename: I
authors.initials: I
authors.lastname: Gukovsky
authors.forename: C
authors.initials: C
authors.lastname: Carrière
authors.forename: A K
authors.initials: AK
authors.lastname: Ryan
authors.forename: A P
authors.initials: AP
authors.lastname: Miller
authors.forename: L
authors.initials: L
authors.lastname: Zuo
authors.forename: A S
authors.initials: AS
authors.lastname: Gleiberman
authors.forename: B
authors.initials: B
authors.lastname: Andersen
authors.forename: W G
authors.initials: WG
authors.lastname: Beamer
authors.forename: M G
authors.initials: MG
authors.lastname: Rosenfeld
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D019070:Cell Lineage; D004268:DNA-Binding Proteins / Q000235:genetics*; D004393:Dwarfism, Pituitary / Q000196:embryology / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D018398:Homeodomain Proteins / Q000235:genetics* / Q000502:physiology; D007031:Hypothalamus / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D010903:Pituitary Gland, Anterior / Q000002:abnormalities / Q000196:embryology* / Q000502:physiology; D017354:Point Mutation; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D050817:Transcription Factor Pit-1; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D050817:Transcription Factor Pit-1; D014157:Transcription Factors; C494185:Pou1f1 protein, mouse; C102134:Prophet of Pit-1 protein