Kinetics of circulating adhesion molecules and chemokines after mechanical trauma and burns.
OBJECTIVE
To assess the role of circulating adhesion molecules and chemotactic cytokines within different settings of major trauma.


METHODS
Retrospective study.


METHODS
Teaching hospitals, USA and Germany.


METHODS
Two groups of patients with multiple injuries (group I n = 155 and group II n = 12) with mean (SEM) injury severity scores (ISS) of 35 (4) and 32 (4) points, respectively, and 18 burned patients with a mean of ISS 38 (9) points.


METHODS
Serum samples were collected at the site of the accident and on admission to the (Group I) as well as during the post-trauma course in the hospital (Group II: days 1, 3, 5, 7, 10; Group III; weekly, up to week 10).


METHODS
Measurement of concentrations of soluble (s) adhesion molecules (sE-selectin, sP-selectin), and chemotactic cytokines (interleukin-8 [IL-8], epithelial cell derived neutrophil activating peptide 78 [ENA-78]) in serum after major mechanical trauma and burns.


RESULTS
High concentrations of ENA-78 and sP-selectin were already present at the site of accident as well as one hour after injury. During recovery from the injuries, persistently high concentrations of IL-8, ENA-78, and sP-selectin were found, but sE-selectin was increased only during the first week after major trauma.


CONCLUSIONS
Massive tissue trauma causes immediate activation of selected chemokines and adhesion molecules within minutes of the injury which will then persist depending on the type and severity of the injury for a substantial length of time. There was, however, no correlation between serum concentrations of the mediators investigated and susceptibility to complications or outcome.
Schinkel
C
C
Department of Surgery, Ludwig-Maximilians-University, Klinikum Grosshadern, Munich, Germany.
Faist
E
E
Zimmer
S
S
Piltz
S
S
Walz
A
A
Rose
R
R
Höcherl
E
E
Herndon
D
D
Schildberg
F W
FW
D000293:Adolescent; D000328:Adult; D001053:Apolipoproteins / Q000032:analysis; D002056:Burns / Q000097:blood*; D054365:Chemokine CXCL5; D018925:Chemokines / Q000097:blood*; D019743:Chemokines, CXC; D019040:E-Selectin / Q000097:blood; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000031:analogs & derivatives / Q000097:blood; D007700:Kinetics; D008297:Male; D009104:Multiple Trauma / Q000097:blood*; D019007:P-Selectin / Q000097:blood; D012189:Retrospective Studies; D019087:Selectins / Q000097:blood*; D000685:Serum Amyloid A Protein / Q000032:analysis
D001053:Apolipoproteins; C486263:CXCL5 protein, human; D054365:Chemokine CXCL5; D018925:Chemokines; D019743:Chemokines, CXC; D019040:E-Selectin; D016209:Interleukin-8; D019007:P-Selectin; D019087:Selectins; D000685:Serum Amyloid A Protein