title: Verapamil sensitive incessant ventricular tachycardia in the newborn.
abstract: Incessant VTs in infancy are often poorly tolerated. Response to conventional antiarrhythmic therapy is disappointing. The present case involves a 3-week-old infant with an incessant VT of a left bundle branch block, and normal axis morphology. This tachycardia was inducible with both atrial and ventricular pacing, but not by premature stimulation. Tachycardia persisted despite treatment with adenosine, esmolol, procainamide, and flecainide. Intravenous verapamil suppressed tachycardia and prevented inducibility, and no further recurrences were seen on oral verapamil. This case suggests that some incessant VTs in infancy may be due to calcium channel related afterdepolarizations or triggered activation.
authors.affiliation: Electrophysiology Laboratory, Children's Hospital of Wisconsin, Milwaukee, USA.
authors.forename: A
authors.initials: A
authors.lastname: Dhala
authors.forename: D A
authors.initials: DA
authors.lastname: Lewis
authors.forename: J
authors.initials: J
authors.lastname: Garland
authors.forename: A N
authors.initials: AN
authors.lastname: Pelech
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D002037:Bundle-Branch Block / Q000150:complications; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D012008:Recurrence; D017180:Tachycardia, Ventricular / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D014700:Verapamil / Q000627:therapeutic use*
chemical_list: D000889:Anti-Arrhythmia Agents; D002121:Calcium Channel Blockers; D014700:Verapamil