title: An echocardiographic study of interactions between pindolol and epinephrine contained in a local anesthetic solution.
abstract: An increasing number of dental patients are taking beta-adrenergic blockers for the treatment of hypertension or angina pectoris. If epinephrine-containing local anesthetics are administered to such patients, interactions between epinephrine and the beta-blocking agent may induce cardiovascular complications. We assessed in volunteers the effects of intraoral injection with 2% lidocaine containing 1:80,000 epinephrine (L-E) on cardiac function after pretreatment with the beta-blocking agent pindolol. M-Mode echocardiography was used for the assessment. The injection of L-E after administration of pindolol did not alter cardiac preload, whereas it reduced the stroke volume, due to an increase in afterload and a decrease in myocardial contractility. Reductions in stroke volume and heart rate led to a decrease in cardiac output. Because total peripheral vascular resistance increased markedly, blood pressure was elevated despite the reduced cardiac output. These results suggest that cardiac function of dental patients on beta-blocker therapy can be adversely affected by epinephrine-containing local anesthetics. Therefore, when such an anesthetic solution has to be used in patients on beta-blocker therapy, careful systemic monitoring is needed.
authors.affiliation: Department of Dental Anesthesiology, Iwate Medical University, School of Dentistry, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sugimura
authors.forename: Y
authors.initials: Y
authors.lastname: Hirota
authors.forename: T
authors.initials: T
authors.lastname: Shibutani
authors.forename: H
authors.initials: H
authors.lastname: Niwa
authors.forename: T
authors.initials: T
authors.lastname: Hori
authors.forename: Y
authors.initials: Y
authors.lastname: Kim
authors.forename: H
authors.initials: H
authors.lastname: Matsuura
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D000704:Analysis of Variance; D000766:Anesthesia, Dental / Q000009:adverse effects; D000779:Anesthetics, Local / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D017742:Dental Care for Chronically Ill; D004347:Drug Interactions; D004452:Echocardiography / Q000379:methods; D004837:Epinephrine / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D010869:Pindolol / Q000494:pharmacology*; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
chemical_list: D000319:Adrenergic beta-Antagonists; D000779:Anesthetics, Local; D014662:Vasoconstrictor Agents; D010869:Pindolol; D004837:Epinephrine