title: Carpal and tarsal bone development is highly sensitive to three antiproliferative teratogens in mice.
abstract: When pregnant mice were given small doses of teratogens (cytosine arabinoside, mitomycin C, or busulfan) that did not induce anomalies of any other organs, a high incidence of carpal and tarsal bone anomalies still occurred. The carpal and tarsal bones may be used as a sensitive target for teratogenicity testing.
authors.affiliation: Department of Hygiene and Preventive Medicine, Yamagata University School of Medicine, Japan.
authors.forename: M E
authors.initials: ME
authors.lastname: Rahman
authors.forename: H
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: A
authors.initials: A
authors.lastname: Endo
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002066:Busulfan / Q000633:toxicity*; D002348:Carpal Bones / Q000002:abnormalities*; D003561:Cytarabine / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D016685:Mitomycin / Q000633:toxicity*; D011247:Pregnancy; D013639:Tarsal Bones / Q000002:abnormalities*
chemical_list: D000970:Antineoplastic Agents; D003561:Cytarabine; D016685:Mitomycin; D002066:Busulfan