[Isoniazid acetylation, its relation to genetic and environmental altitude factors].
Since the discovery of isoniacid in 1952, it has become apparent that there are considerable variations in the manner in which individuals react to the drug. We studied 90 patients from La Paz (3.600 m. over sea level) and 50 patients from Santa Cruz (470 m. over sea level). Our results in the two groups tested suggest that the high altitude hypoxia increases the velocity of inactivation. Despite to the influence of hypoxia it was seen that both groups have the some frequency of rapid and slow inactivators.
Taboada Lopez
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Instituto de Genética Humana, Facultad de Medicina, La Paz, Bolivia.
Navarro de Claure
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ML
D000107:Acetylation; D000293:Adolescent; D000328:Adult; D000368:Aged; D000531:Altitude; D000995:Antitubercular Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D001191:Arylamine N-Acetyltransferase / Q000235:genetics / Q000378:metabolism*; D001711:Biotransformation / Q000235:genetics; D001838:Bolivia / Q000453:epidemiology; D002648:Child; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000201:enzymology*; D007538:Isoniazid / Q000493:pharmacokinetics* / Q000627:therapeutic use; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D013307:Streptomycin / Q000627:therapeutic use; D013828:Thioacetazone / Q000627:therapeutic use; D014376:Tuberculosis / Q000188:drug therapy / Q000201:enzymology / Q000453:epidemiology
D000995:Antitubercular Agents; C047057:isoniazid acetyltransferase; D001191:Arylamine N-Acetyltransferase; D013828:Thioacetazone; D007538:Isoniazid; D013307:Streptomycin