title: The production of colony-stimulating factors by thyroid carcinoma is associated with marked neutrophilia and eosinophilia.
abstract: Cancers producing colony-stimulating factors and associated with marked leukocytosis are relatively rare. We report here a case of a thyroid cancer producing both granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF). A 72-year-old woman had a thyroid carcinoma with significant neutrophilia and eosinophilia without any evidence of infection. The serum concentrations of both G-CSF and GM-CSF were elevated significantly in this patient, which might have induced the leukocytosis. Furthermore, the G-CSF concentrations in thyroid tumor tissue and metastatic lesions in the lung and skin examined at autopsy also were extremely high.
authors.affiliation: Department of Internal Medicine (I), Daisan Hospital, Jikei University School of Medicine, Tokyo.
authors.forename: T
authors.initials: T
authors.lastname: Nakada
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: F
authors.initials: F
authors.lastname: Inoue
authors.forename: F
authors.initials: F
authors.lastname: Mizorogi
authors.forename: K
authors.initials: K
authors.lastname: Nagayama
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor; D001706:Biopsy; D002277:Carcinoma / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D003115:Colony-Stimulating Factors / Q000096:biosynthesis*; D004802:Eosinophilia / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D017809:Fatal Outcome; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000096:biosynthesis; D006801:Humans; D007964:Leukocytosis / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D009504:Neutrophils; D013964:Thyroid Neoplasms / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D003115:Colony-Stimulating Factors; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor