title: Peripheral blood mononuclear cells of patients with Indian visceral leishmaniasis suppress natural killer cell activity in vitro.
abstract: Peripheral blood mononuclear cells (PBMC) of patients with Indian visceral leishmaniasis (VL) suppressed the natural killer cell (NK) activity of normal human PBMC in vitro in a dose-dependent manner. Adherent monocytes, but not the non-adherent lymphocytes of VL patients suppressed NK activity through soluble mediators. The level of suppression seen in different patients was variable.
authors.affiliation: Indian Institute of Chemical Biology, Calcutta, India.
authors.forename: G
authors.initials: G
authors.lastname: Chakrabarti
authors.forename: A
authors.initials: A
authors.lastname: Basu
authors.forename: P P
authors.initials: PP
authors.lastname: Manna
authors.forename: S
authors.initials: S
authors.lastname: Bhattacharya
authors.forename: S
authors.initials: S
authors.lastname: Sen
authors.forename: S
authors.initials: S
authors.lastname: Bandyopadhyay
mesh_terms: D002448:Cell Adhesion; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007108:Immune Tolerance; D007694:Killer Cells, Natural / Q000276:immunology*; D007898:Leishmaniasis, Visceral / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D009000:Monocytes / Q000276:immunology