title: Intramuscular diclofenac versus intravenous indomethacin in the treatment of acute renal colic.
abstract: OBJECTIVE
  We have conducted a clinical trial to compare the pain-relieving effect and safety of diclofenac administered intramuscularly to indomethacin given intravenously.
  
  
  METHODS
  The study was designed as a randomized single-blind trial. It was carried out at Oslo Emergency Hospital (outpatient setting or stay < 24 h). 41 patients with a mean age of 41.6 years received 75 mg diclofenac and 42 patients with a mean age of 45.2 years were given 50 mg indomethacin. The two groups were similar in regard to baseline characteristics except gender distribution.
  
  
  RESULTS
  Statistically significant reduction in pain intensity was achieved after 5 min in the diclofenac group (p < 0.01), and after 10 min in the indomethacin group (p < 0.01). The probability of having pain after 1 h was 52% in the indomethacin group and 37% in the diclofenac group (p = 0.11). Rescue medication with pethidine after 2 h was given in 9 and 5 patients, respectively. Four patients in the diclofenac group reported one occurrence of adverse effect each, while 9 patients on indomethacin experienced 14 occurrences, mainly dizziness and nausea.
  
  
  CONCLUSIONS
  These findings together with a simpler mode of administration indicate that diclofenac may be preferred in the analgesic treatment of renal colic.
authors.affiliation: Department of General Practice, University of Oslo, Norway.
authors.forename: E
authors.initials: E
authors.lastname: Laerum
authors.forename: O E
authors.initials: OE
authors.lastname: Ommundsen
authors.forename: J E
authors.initials: JE
authors.lastname: Grønseth
authors.forename: A
authors.initials: A
authors.lastname: Christiansen
authors.forename: H E
authors.initials: HE
authors.lastname: Fagertun
mesh_terms: D000208:Acute Disease; D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage; D003085:Colic / Q000188:drug therapy*; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D004008:Diclofenac / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage* / Q000009:adverse effects; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007674:Kidney Diseases / Q000188:drug therapy*; D008297:Male; D008614:Meperidine / Q000008:administration & dosage; D016037:Single-Blind Method
chemical_list: D000701:Analgesics, Opioid; D016861:Cyclooxygenase Inhibitors; D004008:Diclofenac; D008614:Meperidine; D007213:Indomethacin