title: Resistance patterns of Streptococcus pneumoniae and Haemophilus influenzae isolates recovered in Egypt from children with pneumonia. The Antimicrobial Resistance Surveillance Study Group.
abstract: Treatment of childhood pneumonia in developing countries requires knowledge of susceptibility patterns for Streptococcus pneumoniae and Haemophilus influenzae. Between October 1991 and April 1993, a surveillance survey of antimicrobial resistance was performed at two fever hospitals in Egypt; nasopharyngeal swab and blood specimens obtained from 1,635 children with pneumonia were cultured for these organisms. Susceptibility testing of these organisms was performed. At least one of these organisms was isolated from nasopharyngeal swab specimens from 73% of the children; 3.7% of blood cultures were positive. For S. pneumoniae strains, 70.9% of nasopharyngeal isolates were calculated to be susceptible to penicillin vs. 77.6% of blood isolates; the percentages of isolates susceptible to co-trimoxazole were 73.0% and 75.0%, respectively. For H. influenzae strains, 93.0% of nasopharyngeal isolates were calculated to be susceptible to ampicillin vs. 100% of blood isolates; the percentages of isolates susceptible to co-trimoxazole were 84.9% and 100%, respectively. Although most S. pneumoniae and H. influenzae strains associated with childhood pneumonia in Cairo were susceptible to penicillins and co-trimoxazole, antimicrobial resistance did not occur.
authors.affiliation: National Center for Infectious Diseases, Centers for Diseases Control and Prevention, Atlanta, Georgia 30333, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Ostroff
authors.forename: L H
authors.initials: LH
authors.lastname: Harrison
authors.forename: N
authors.initials: N
authors.lastname: Khallaf
authors.forename: M T
authors.initials: MT
authors.lastname: Assaad
authors.forename: N I
authors.initials: NI
authors.lastname: Guirguis
authors.forename: S
authors.initials: S
authors.lastname: Harrington
authors.forename: M
authors.initials: M
authors.lastname: el-Alamy
mesh_terms: D000667:Ampicillin / Q000494:pharmacology*; D000668:Ampicillin Resistance; D002675:Child, Preschool; D002701:Chloramphenicol / Q000494:pharmacology*; D002702:Chloramphenicol Resistance; D004534:Egypt; D005260:Female; D006192:Haemophilus Infections / Q000097:blood / Q000382:microbiology* / Q000473:pathology; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology*; D011008:Pneumococcal Infections / Q000097:blood / Q000382:microbiology* / Q000473:pathology; D011014:Pneumonia / Q000097:blood / Q000382:microbiology* / Q000473:pathology; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification; D014296:Trimethoprim Resistance; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology*
chemical_list: D010406:Penicillins; D002701:Chloramphenicol; D000667:Ampicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination