title: New naphthyloxyalkyl beta-diketone and 3,5-dimethylisoxazole derivatives as potential antiviral agents.
abstract: Ten new compounds having 3-[(2-naphthyloxy)alkyl]-2,4-pentanedione and 4-[(2-naphthyloxy)alkyl]-3,5-dimethylisoxazole structures were synthesized and their cytotoxicities and antiviral activities investigated. 3-[6-(2-Naphthyloxy)hexyl]-2,4-pentandione possessing inhibitory activity on the replication of both adenovirus type 5 and poliovirus type 1 at 20 micrograms/ml was the most active compound in the series.
authors.affiliation: Hacettepe University, Faculty of Pharmacy, Dept. of Pharmaceutical Chem., Ankara-Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Balkan
authors.forename: H
authors.initials: H
authors.lastname: Akgün
authors.forename: N
authors.initials: N
authors.lastname: Parali
authors.forename: M
authors.initials: M
authors.lastname: Ertan
authors.forename: C
authors.initials: C
authors.lastname: Açikgöz
authors.forename: S
authors.initials: S
authors.lastname: Ustaçelebi
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000998:Antiviral Agents; D007555:Isoxazoles