Sensing the heat: the application of isothermal titration calorimetry to thermodynamic studies of biomolecular interactions.
Biomolecular interactions can be defined by combining thermodynamic data on the energetic properties of the interaction with high-resolution structural data. The development of high sensitivity isothermal titration calorimetric equipment provides a dramatic advance in the gathering of thermodynamic data, and the interactions between biological macromolecules can now be described with unprecedented accuracy.
Ladbury
J E
JE
Department of Biochemistry, University College London, 91 Riding House Street, London W1P 8BT, UK.
Chowdhry
B Z
BZ
D002151:Calorimetry; D018360:Crystallography, X-Ray; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D015398:Signal Transduction; D013816:Thermodynamics
D011506:Proteins