Anaplastic large-cell lymphoma (Ki-1 lymphoma) with expression of IL-5 mRNA and eosinophilic invasion.
We examined a patient with anaplastic large-cell lymphoma (Ki-1 lymphoma) showing eosinophilic invasion of the tumor tissues. The number of eosinophils in the peripheral blood changed as a function of the stage of the disease. The IL-5 gene was expressed in the tumor tissues, suggesting that the eosinophilic invasion and eosinophilia were caused by IL-5 derived from the lymphoma cells.
Takimoto
Y
Y
Department of Internal Medicine, Hiroshima University, Japan.
Tanaka
H
H
Tanabe
O
O
Kuramoto
A
A
Sasaki
N
N
Nanba
K
K
D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives; D004802:Eosinophilia / Q000150:complications* / Q000235:genetics; D017809:Fatal Outcome; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D015848:Interleukin-5 / Q000235:genetics*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage
D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D015848:Interleukin-5; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone; C027260:pirarubicin; D002945:Cisplatin