Antiandrogen. IV. C-17 spiro 2-oxasteroids.
The preparation of 6- and/or 7-substituted 3-oxo-2-oxasteroids having a spirotetrahydrofuran ring at the 17-position is described. These compounds showed high antiandrogenic potency in the castrated male rat.
Koizumi
N
N
Research Department, Teikoku Hormone Mfg. Co., Ltd., Kawasaki, Japan.
Takegawa
S
S
Mieda
M
M
Shibata
K
K
D000726:Androgen Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D005260:Female; D005837:Genitalia, Male / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009919:Orchiectomy; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013256:Steroids / Q000138:chemical synthesis* / Q000494:pharmacology
D000726:Androgen Antagonists; D013256:Steroids