Rasmussen's encephalitis: an autoimmune disorder?
Rasmussen's encephalitis is a rare progressive pediatric epileptic syndrome. Recent evidence from experimental animals and patients with the disease suggests an important role for both humoral and cell-mediated immune mechanisms in the pathogenesis of this disease. The glutamate receptor subunit GluR3 may be an important autoantigen in the disease. (This review has been modified from a review published in Current Opinion in Neurology 1996, 9:141-145.)
Andrews
P I
PI
Duke Center for the Advanced Study of Epilepsy, Duke University Medical Center, Durham, North Carolina 27710, USA.
McNamara
J O
JO
D000818:Animals; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D004660:Encephalitis / Q000276:immunology; D004827:Epilepsy / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007111:Immunity, Cellular; D018448:Models, Immunological; D017470:Receptors, Glutamate / Q000276:immunology
D001324:Autoantigens; D017470:Receptors, Glutamate