title: Correlation between scanning laser ophthalmoscope microperimetry and anatomic abnormalities in patients with subfoveal neovascularization.
abstract: OBJECTIVE
  The purpose of the study is to identify the anatomic abnormalities associated with an absolute scotoma and the location and stability of fixation in patients with subfoveal neovascularization in age-related macular degeneration, presumed ocular histoplasmosis syndrome, and other disorders.
  
  
  METHODS
  Scanning laser ophthalmoscope microperimetry was superimposed on color fundus photographs and fluorescein angiograms of 21 eyes with subfoveal neovascular membranes secondary to age-related macular degeneration (14 eyes) and presumed ocular histoplasmosis syndrome (7 eyes). The authors determined the location and the area occupied by the absolute scotoma and each of the following subretinal lesions: subretinal hemorrhage, neurosensory retinal detachment, retinal pigment epithelial (RPE) atrophy, RPE hyperplasia, atrophy of the choriocapillaris, hard exudates, and the subfoveal neovascular membrane. The area of absolute scotoma determined by scanning laser ophthalmoscope microperimetry was superimposed on the anatomic lesions. The authors calculated the relative risk ratio (RR) of an absolute scotoma occurring in regions corresponding to each anatomic abnormality, and determined the preferred location and stability of fixation in each eye.
  
  
  RESULTS
  An absolute scotoma was present in areas of chorioretinal scar (RR = 107.61), RPE atrophy (RR = 9.97), subretinal hemorrhage (RR = 2.88), and the neovascular membrane (RR = 1.86). Fixation was stable in all patients with presumed ocular histoplasmosis syndrome but only 29% of patients with age-related macular degeneration. Fifty-five percent of patients with stable fixation fixated over an area of RPE hyperplasia.
  
  
  CONCLUSIONS
  The relative risk of an absolute scotoma is highest over areas of chorioretinal scars, RPE atrophy, subretinal hemorrhage, and the neovascular membrane. Fixation is more stable in patients with subfoveal neovascularization from presumed ocular histoplasmosis syndrome than with age-related macular degeneration and frequently is present over an area of RPE hyperplasia.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA.
authors.forename: T H
authors.initials: TH
authors.lastname: Tezel
authors.forename: L V
authors.initials: LV
authors.lastname: Del Priore
authors.forename: B E
authors.initials: BE
authors.lastname: Flowers
authors.forename: D H
authors.initials: DH
authors.lastname: Grosof
authors.forename: I L
authors.initials: IL
authors.lastname: Benenson
authors.forename: R L
authors.initials: RL
authors.lastname: Zamora
authors.forename: H J
authors.initials: HJ
authors.lastname: Kaplan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015821:Eye Infections, Fungal / Q000150:complications; D005260:Female; D005403:Fixation, Ocular; D005451:Fluorescein Angiography; D005584:Fovea Centralis; D005654:Fundus Oculi; D006660:Histoplasmosis / Q000150:complications; D006801:Humans; D007834:Lasers; D008268:Macular Degeneration / Q000150:complications; D008297:Male; D008875:Middle Aged; D019721:Ophthalmoscopes; D010781:Photography; D012160:Retina / Q000473:pathology*; D015861:Retinal Neovascularization / Q000209:etiology / Q000473:pathology*; D012607:Scotoma / Q000473:pathology; D058609:Visual Field Tests / Q000379:methods*