Some analytical considerations on the measurement of prostate-specific antigen.
In this study, various analytical aspects of the determination of serum prostate-specific antigen are described as applied to the Abbott IMx PSA and the Hybritech Tandem-E PSA assays. We used mainly specimens from a prostate cancer screening study in progress. A very good comparability between the assays proved to exist in our hands. The long-run variation (16 months) was also rated as acceptable, both for the IMx and the Tandem-E method. The method of choice, Tandem-E, showed good reagent stability over this period. We found, however, a difference in accuracy (Tandem-E +/- 8% higher values) that could not be explained by comparison with Tandem-R.
Blijenberg
B G
BG
Department of Clinical Chemistry, University Hospital Rotterdam, The Netherlands.
Kranse
R
R
Eman
I
I
Schröder
F H
FH
D006801:Humans; D008297:Male; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood; D011933:Reagent Kits, Diagnostic
D011933:Reagent Kits, Diagnostic; D017430:Prostate-Specific Antigen