title: Natriuretic peptides in sheep with pressure overload left ventricular hypertrophy.
abstract: To examine tissue and plasma atrial (ANP) and brain natriuretic peptide (BNP) responses to left ventricular hypertrophy (LVH) 7 sheep underwent suprarenal aortic banding (20 mmHg initial pressure differential). Median survival time was 15 days. Proximal mean aortic pressure (MAP) increased from 65.1 +/- 5.0 mmHg (baseline) to 111.6 +/- 7.5 mmHg (day 7, p < 0.0001). Distal systolic aortic pressure fell from 85.5 +/- 8.7 mmHg (baseline) to 55.6 +/- 6.4 mmHg (day 7, p = 0.0002). Maximal plasma ANP (26.9 +/- 3.6 vs 10.1 +/- 1.2 pmol/L, p = 0.005) and BNP (15.3 +/- 3.6 vs. 3.5 +/- 1.0 pmol/L, p = 0.006) were recorded at 15 +/- 4.0 days. Coarctation induced rapid increases in PRA and plasma aldosterone and a fall in urinary sodium. Post-mortem examination of hearts confirmed LVH. Compared with controls, tissue ANP concentration was reduced in left atrium (p = 0.04) and LV (p = 0.04). BNP concentration was reduced in left atrium (p = 0.02) but tended to be higher in LV. In conclusion, suprarenal aortic coarctation leads to progressive hypertension resulting in LVH, progressive increases in plasma ANP and BNP and, in most cases, death from heart failure.
authors.affiliation: Department of Endocrinology, Christchurch Hospital, New Zealand.
authors.forename: C J
authors.initials: CJ
authors.lastname: Charles
authors.forename: R J
authors.initials: RJ
authors.lastname: Kaaja
authors.forename: E A
authors.initials: EA
authors.lastname: Espiner
authors.forename: M G
authors.initials: MG
authors.lastname: Nicholls
authors.forename: C J
authors.initials: CJ
authors.lastname: Pemberton
authors.forename: A M
authors.initials: AM
authors.lastname: Richards
authors.forename: T G
authors.initials: TG
authors.lastname: Yandle
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood*; D006439:Hemodynamics; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000503:physiopathology; D020097:Natriuretic Peptide, Brain; D009419:Nerve Tissue Proteins / Q000097:blood*; D011312:Pressure; D012756:Sheep
chemical_list: D009419:Nerve Tissue Proteins; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor