The in-vitro anti-rickettsial activity of macrolides.
The anti-rickettsial activity of azithromycin and clarithromycin was studied in Vero cells. The rate of rickettsial inhibition-growth caused by both macrolides was determined using rickettsial counts and ELISA. Both macrolides inhibited > 50% the growth of Rickettsia conorii and Rickettsia typhi at concentrations of 1.0 and 0.1 mg/L, respectively. The growth of Coxiella burnetii was inhibited to a rate of > or = 50% at the concentrations of 0.01 and 1.0 mg/L of azithromycin and clarithromycin, respectively.
Keysary
A
A
Department of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona, Israel. xiibr@weizmann.weizmann.ac.il
Itzhaki
A
A
Rubinstein
E
E
Oron
C
C
Keren
G
G
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D017291:Clarithromycin / Q000494:pharmacology*; D015169:Colony Count, Microbial; D016997:Coxiella burnetii / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D012281:Rickettsia / Q000187:drug effects* / Q000254:growth & development; D012286:Rickettsia typhi / Q000187:drug effects* / Q000254:growth & development; D014709:Vero Cells
D000900:Anti-Bacterial Agents; D017963:Azithromycin; D017291:Clarithromycin