Evaluations of enzyme-linked immunosorbent assay procedure for determining specific Epstein-Barr virus serology and of rapid test kits for diagnosis for infectious mononucleosis.
Using the results of Epstein-Barr virus-specific immunofluorescence serology as the "gold standard," we found that the sensitivities of the five rapid test kits varied from 78 to 84% and specificities varied from 89 to 100%. Enzyme-linked immunosorbent assay-determined specific Epstein-Barr virus antibody profiles had a sensitivity and specificity of 98.6 and 95.5%, respectively.
Gerber
M A
MA
Department of Pediatrics, University of Connecticut, School of Medicine, Connecticut Children's Medical Center, Hartford 06106, USA.
Shapiro
E D
ED
Ryan
R W
RW
Bell
G L
GL
D000914:Antibodies, Viral / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods* / Q000592:standards / Q000706:statistics & numerical data; D005069:Evaluation Studies as Topic; D005455:Fluorescent Antibody Technique / Q000592:standards / Q000706:statistics & numerical data; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007244:Infectious Mononucleosis / Q000175:diagnosis* / Q000276:immunology*; D012015:Reference Standards; D012680:Sensitivity and Specificity; D014773:Virology / Q000379:methods* / Q000592:standards / Q000706:statistics & numerical data
D000914:Antibodies, Viral