Baclofen pretreatment attenuates the suppressant effect of intraperitoneal administration of cholecystokinin (CCK) on food intake in rats.
The aim of this study was to investigate whether pretreatment with the GABAB receptor agonist baclofen could prevent the inhibitory effect of systemically administered cholecystokinin (CCK) on food intake in rats. Baclofen (2 mg/kg, SC) administered 60 min prior to IP injection of CCK (5 micrograms/kg) significantly attenuated the suppressant effect of the peptide on feeding in nondeprived rats (Experiment 1) and rats that had been deprived of food for 22 h (Experiment 2). Baclofen had no significant effects on food intake when administered alone. The results suggest that the inhibitory effect of exogenous peripheral CCK on food intake may be dependent on an interaction with a GABAB-receptor mediated mechanism.
Ebenezer
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Neuropharmacology Research Group, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Hampshire, England.
D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D002766:Cholecystokinin / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004435:Eating / Q000187:drug effects*; D018755:GABA Agonists / Q000494:pharmacology*; D058785:GABA-A Receptor Agonists; D058786:GABA-B Receptor Agonists; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000378:metabolism; D018080:Receptors, GABA-B / Q000378:metabolism; D012528:Satiety Response / Q000187:drug effects
D018755:GABA Agonists; D058785:GABA-A Receptor Agonists; D058786:GABA-B Receptor Agonists; D011963:Receptors, GABA-A; D018080:Receptors, GABA-B; D002766:Cholecystokinin; D001418:Baclofen