Strategies to alter the progression of Alzheimer's disease.
Recent advances in the genetics of familial Alzheimer's disease provide direction for therapeutic strategies to alter the progressive neurodegeneration. The rationale is particularly strong for targeting the deposition of amyloid into neuritic plaques, but attention has also turned to abnormalities in apoptosis and signal-transduction processes.
Siman
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Cephalon Inc, 145 Brandywine Parkway, West Chester, PA 19380, USA. rsiman.cephalon@notes.ccmail.compuserve.com
Scott
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D000544:Alzheimer Disease / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D000682:Amyloid / Q000187:drug effects; D001057:Apolipoproteins E / Q000235:genetics; D018450:Disease Progression; D015195:Drug Design; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D009154:Mutation; D009410:Nerve Degeneration / Q000187:drug effects / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics; D053764:Presenilin-1
D000682:Amyloid; D001057:Apolipoproteins E; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1