Lack of association of the apoE4 allele with hippocampal sclerosis dementia.
We determined the apolipoprotein E4 (apoE) genotype in 12 cases of autopsy-confirmed hippocampal sclerosis dementia (HSD), a disorder characterized pathologically by neuronal degeneration, predominantly of temporal lobe structures, without senile plaques or neurofibrillary tangles. The frequency of the apoE4 allele in HSD was 12.5%, similar to that of a control population and significantly different from the approximately 40% found in Alzheimer's disease (AD) (P < 0.001). These observations suggest that apoE4 is not a risk factor for HSD.
Troncoso
J C
JC
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kawas
C H
CH
Chang
C K
CK
Folstein
M F
MF
Hedreen
J C
JC
D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics / Q000473:pathology; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D003704:Dementia / Q000235:genetics* / Q000473:pathology; D005260:Female; D005838:Genotype; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000235:genetics* / Q000473:pathology; D016612:Paraffin Embedding; D012598:Sclerosis
D053327:Apolipoprotein E4; D001057:Apolipoproteins E