title: Common acute lymphoblastic leukemia preceded by hypercalcemia in an infant.
abstract: A case of common acute lymphoblastic leukemia (ALL) preceded by hypercalcemia was observed in an infant. A high blood level of parathyroid hormone related protein (PTH-rP) was detected during the first examination at Ohashi Hospital. Treatment with antineoplastic agents led to complete remission. The blood PTH-rP level decreased as a result of treatment. PTH-rP produced by leukemic cells was though to be the cause of the hypercalcemia.
authors.affiliation: Second Department of Pediatrics, Ohashi Hospital, Toho University School of Medicine, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ohoishi
authors.forename: T
authors.initials: T
authors.lastname: Koshibu
authors.forename: H
authors.initials: H
authors.lastname: Kazama
authors.forename: N
authors.initials: N
authors.lastname: Shinomiya
authors.forename: T
authors.initials: T
authors.lastname: Aoki
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000209:etiology*; D007223:Infant; D044162:Parathyroid Hormone-Related Protein; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D011506:Proteins / Q000378:metabolism*; D012074:Remission Induction
chemical_list: C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins; D002118:Calcium