Effects of serotonin on different patterns of low Mg(2+)-induced epileptiform activity in the subiculum of rats studied in vitro.
The subiculum is an epilepsy-prone area within the hippocampal complex that receives a dense serotonergic innervation from the raphe nuclei. We investigated the effect of 5-HT on epileptiform activity in this region with intra- and extracellular recordings. Our data suggest that 5-HT has predominately inhibitory effects on epileptiform activity in the subiculum but in some cases could also function as a disinhibitory agent. As the subiculum is an important output station of the hippocampal complex the serotonergic innervation might influence the spread of epileptic seizures.
Behr
J
J
Institute of Physiology at the Charité, Department of Neurophysiology, Humboldt University Berlin, Germany. behr@comcom.rz.charite.hu-berlin.de
Heinemann
U
U
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D004827:Epilepsy / Q000139:chemically induced*; D005260:Female; D006624:Hippocampus / Q000187:drug effects* / Q000503:physiopathology; D008274:Magnesium; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009924:Organ Culture Techniques; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000494:pharmacology*
D012701:Serotonin; D008274:Magnesium