title: Improved quality of life in patients with generalized cardiovascular metabolic disease on a prepared diet.
abstract: Current dietary recommendation for cardiovascular disease risk reduction and recommended dietary allowances (RDAs) were used to develop a nutritionally complete prepackaged prepared meal plan specifically designed to reduce the risk of cardiovascular disease. In the current study we tested patient acceptance of the diet as defined by measures of quality of life. In a randomized, parallel-design, multicenter clinical trial, 77 persons with hypertension, diabetes mellitus, dyslipidemia, or a combination of two or more of these conditions were recruited and randomly assigned to either a prepared meal plan (n = 39) or a comparable self-selected diet (n = 38) for 10 wk. The prepared meal plan met both the RDAs for all essential micronutrients and the dietary recommendations of national health organizations for macronutrients, cholesterol, sodium, and fiber. The prescribed self-selected diet was matched for macronutrients. Quality of life, as measured by a battery of instruments, was the major endpoint. Individuals consuming the prepared meal plan had significant improvements in mental health (P < 0.01), general perceived health (P < 0.005), daily activities (P < 0.05), work performance (P < 0.005), affect (P < 0.01), and nutritional health perceptions (P < 0.001), and reductions in nutrition hassles based on a standardized questionnaire (P < 0.001). The self-selected-diet group had significant improvements in nutritional health perceptions (P < 0.001) and affect (P < 0.001). There were significant improvements in weight (P < 0.001), blood pressure (P < 0.001), cholesterol (P < 0.002), low-density lipoproteins (P < 0.001), glucose (P < 0.014), and glycated hemoglobin (Hb A(1c) (P < 0.004) that were comparable in both groups. In summary, this study shows that a nutritionally complete diet, whether prepackaged or self-selected, improves multiple risk factors for cardiovascular disease. The prepackaged prepared meal plan had the added benefit of a greater improvement in quality of life.
authors.affiliation: McMaster University, Health Sciences Centre, Hamilton, Canada.
authors.forename: D C
authors.initials: DC
authors.lastname: Hatton
authors.forename: R B
authors.initials: RB
authors.lastname: Haynes
authors.forename: S
authors.initials: S
authors.lastname: Oparil
authors.forename: P
authors.initials: P
authors.lastname: Kris-Etherton
authors.forename: F X
authors.initials: FX
authors.lastname: Pi-Sunyer
authors.forename: L M
authors.initials: LM
authors.lastname: Resnick
authors.forename: J S
authors.initials: JS
authors.lastname: Stern
authors.forename: S
authors.initials: S
authors.lastname: Clark
authors.forename: M
authors.initials: M
authors.lastname: McMahon
authors.forename: C
authors.initials: C
authors.lastname: Morris
authors.forename: J
authors.initials: J
authors.lastname: Metz
authors.forename: A
authors.initials: A
authors.lastname: Ward
authors.forename: S
authors.initials: S
authors.lastname: Holcomb
authors.forename: D A
authors.initials: DA
authors.lastname: McCarron
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D002318:Cardiovascular Diseases / Q000178:diet therapy* / Q000378:metabolism / Q000503:physiopathology*; D002784:Cholesterol / Q000097:blood; D003920:Diabetes Mellitus / Q000178:diet therapy / Q000378:metabolism / Q000503:physiopathology; D004035:Diet Therapy / Q000592:standards; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006949:Hyperlipidemias / Q000178:diet therapy / Q000378:metabolism / Q000503:physiopathology; D006973:Hypertension / Q000178:diet therapy / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009751:Nutritional Requirements; D017060:Patient Satisfaction; D011788:Quality of Life; D012307:Risk Factors; D012649:Self Concept; D011795:Surveys and Questionnaires
chemical_list: D001786:Blood Glucose; D002784:Cholesterol; D006442:Glycated Hemoglobin