Sequence and polymorphism analysis of the murine gene encoding histidyl-tRNA synthetase.
The murine histidyl-tRNA synthetase-encoding gene (MMHRS) coding region has been cloned and sequenced. The 1527-bp transcript shows a strikingly similar structural organization to that of its human counterpart, particularly within the three class II aminoacyl-tRNA synthetase structural motifs and the two histidyl-tRNA synthetase signature regions. It is predicted, as in humans, to have a coiled-coil alpha-helical structure that is characteristic of many autoantigens. MMHRS shows some degree of polymorphism at both the DNA and amino-acid levels, although its sequence is well conserved amongst the commonly used laboratory mouse strains.
Blechynden
L M
LM
Australian Neuromuscular Research Institute, Queen Elizabeth II Medical Centre, Nedlands, Australia.
Lawson
C M
CM
Garlepp
M J
MJ
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D004247:DNA; D006643:Histidine-tRNA Ligase / Q000235:genetics*; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity
D004247:DNA; D006643:Histidine-tRNA Ligase