Isolation and characterization of csbB, a gene controlled by Bacillus subtilis general stress transcription factor sigma B.
In the bacterium Bacillus subtilis (Bs), the alternative transcription factor sigma B is activated by environmental stresses to control the expression of a large set of unlinked genes. However, the range of physiological functions mediated by these sigma B-controlled genes is presently unknown. We report here that the newly identified gene csbB is under the dual control of a sigma B-dependent and a sigma B-independent promoter. The predicted product of csbB is a 329 residue protein containing two potential membrane-spanning segments in its C-terminal region, leading us to speculate that one class of sigma B-controlled genes acts to modify the cell envelope as part of the general stress response.
Akbar
S
S
Department of Food Science and Technology, University of California, Davis 95616, USA.
Price
C W
CW
D000595:Amino Acid Sequence; D001412:Bacillus subtilis / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism*; D001483:Base Sequence; D002876:Chromosomes, Bacterial; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D015964:Gene Expression Regulation, Bacterial; D006360:Heat-Shock Proteins / Q000737:chemistry / Q000235:genetics*; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics*; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D011401:Promoter Regions, Genetic; D012808:Sigma Factor / Q000378:metabolism*
D001426:Bacterial Proteins; C102289:CbsB protein, Bacillus subtilis; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D006360:Heat-Shock Proteins; D008565:Membrane Proteins; C079011:SigB protein, Bacteria; D012808:Sigma Factor