Comparisons of morphology and growth rate between cells from skin biopsies of schizophrenic patients and those from normal individuals.
Skin biopsies have been used to establish cell cultures from ten schizophrenic individuals and ten controls. Studies of the time of outgrowth of different cell types from the tissue fragments and the subsequent growth rates and morphology showed no difference between the primary cultures from the schizophrenic patients and controls. The primary cultures were trypsinized and grown for three passages before storing in liquid nitrogen. No difference between cell strains established from schizophrenic skin donors and cell strains from healthy controls was noted in this phase of growth. Aliquots of cells were thawed out from liquid nitrogen, grown for one passage and then the cell aggregation rate was tested. No difference was found between cells from schizophrenic skin donors and cells from controls. Differences between the two cell strains established from certain individuals did occur, suggesting that morphology and growth rates should be noted before cell strains are used for further studies.
Gliddon
A E
AE
Institute of Biological Psychiatry, University of Wales, Bangor, Gwynedd, UK.
Ramchand
C N
CN
Hemmings
G P
GP
D000293:Adolescent; D000328:Adult; D002455:Cell Division / Q000502:physiology*; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D008297:Male; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis / Q000473:pathology*; D012867:Skin / Q000473:pathology*; D014019:Tissue Donors