Using multiple decrement models to estimate risk and morbidity from specific AIDS illnesses. Multicenter AIDS Cohort Study (MACS).
A simple non-parametric approach is developed to simultaneously estimate net incidence and morbidity time from specific AIDS illnesses in populations at high risk for death from these illnesses and other causes. The disease-death process has four-stages that can be recast as two sandwiching three-state multiple decrement processes. Non-parametric estimation of net incidence and morbidity time with error bounds are achieved from these sandwiching models through modification of methods from Aalen and Greenwood, and bootstrapping. An application to immunosuppressed HIV-1 infected homosexual men reveals that cytomegalovirus disease, Kaposi's sarcoma and Pneumocystis pneumonia are likely to occur and cause significant morbidity time.
Hoover
D R
DR
Department of Epidemiology, Johns Hopkins University School of Public Health, Baltimore, Maryland, 21205, USA.
Peng
Y
Y
Saah
A J
AJ
Detels
R R
RR
Day
R S
RS
Phair
J P
JP
D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000453:epidemiology*; D015331:Cohort Studies; D003586:Cytomegalovirus Infections / Q000150:complications / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D015233:Models, Statistical; D009017:Morbidity; D015337:Multicenter Studies as Topic; D011020:Pneumonia, Pneumocystis / Q000150:complications / Q000453:epidemiology; D012307:Risk Factors; D012514:Sarcoma, Kaposi / Q000150:complications / Q000453:epidemiology; D018709:Statistics, Nonparametric; D013997:Time Factors