title: Selection of biologically active peptides by phage display of random peptide libraries.
abstract: Random peptide libraries displayed on phage are used as a source of peptides for epitope mapping, for the identification of critical amino acids responsible for protein-protein interactions and as leads for the discovery of new therapeutics. Efficient and simple procedures have been devised to select peptides binding to purified proteins, to monoclonal and polyclonal antibodies and to cell surfaces in vivo and in vitro.
authors.affiliation: Istituto di Ricerche di Biologia Molecolare P. Angeletti, Via Pontina km 30.600, 00040 Pomezia (Roma), Italy. cortese@irbm.it
authors.forename: R
authors.initials: R
authors.lastname: Cortese
authors.forename: P
authors.initials: P
authors.lastname: Monaci
authors.forename: A
authors.initials: A
authors.lastname: Luzzago
authors.forename: C
authors.initials: C
authors.lastname: Santini
authors.forename: F
authors.initials: F
authors.lastname: Bartoli
authors.forename: I
authors.initials: I
authors.lastname: Cortese
authors.forename: P
authors.initials: P
authors.lastname: Fortugno
authors.forename: G
authors.initials: G
authors.lastname: Galfrè
authors.forename: A
authors.initials: A
authors.lastname: Nicosia
authors.forename: F
authors.initials: F
authors.lastname: Felici
mesh_terms: D000818:Animals; D000941:Antigens / Q000737:chemistry / Q000378:metabolism; D001435:Bacteriophages / Q000235:genetics*; D001665:Binding Sites; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D018604:Epitope Mapping; D015723:Gene Library; D005822:Genetic Vectors; D006801:Humans; D009928:Organ Specificity; D010455:Peptides / Q000737:chemistry / Q000276:immunology / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism
chemical_list: D000941:Antigens; D010455:Peptides; D011506:Proteins