Receptor signalling: to sevenless, a daughter.
Genetic studies with Drosophila identified what appeared to be a linear signalling cassette connecting extracellular signals to nuclear responses. But the discovery of a substrate for the Sevenless receptor indicates that the concept of a single, linear pathway may be an oversimplification.
MacDougall
L K
LK
Ludwig Institute for Cancer Research, University College Branch, London, UK.
Waterfield
M D
MD
D000818:Animals; D004330:Drosophila; D029721:Drosophila Proteins; D005136:Eye Proteins / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000502:physiology; D017956:Photoreceptor Cells, Invertebrate / Q000166:cytology; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
C100319:Dos protein, Drosophila; D029721:Drosophila Proteins; D005136:Eye Proteins; D008562:Membrane Glycoproteins; D020794:Receptor Protein-Tyrosine Kinases; C056737:sev protein, Drosophila