title: Parosteal osteosarcoma: value of MR imaging and CT in the prediction of histologic grade.
abstract: OBJECTIVE
  To evaluate the use of magnetic resonance (MR) imaging and computed tomography (CT) for predicting the histologic grade of parosteal osteosarcomas.
  
  
  METHODS
  Sixty parosteal osteosarcomas were analyzed for tumor size and location, presence of a cleavage plane, intramedullary extension, soft-tissue mass (distinct from ossified mass), and the presence and pattern of ossification. Axial and longitudinal views were evaluated for specific osseous sites within the bone. Tumors were classified as low grade (grade 1) or high grade (grades 2-3).
  
  
  RESULTS
  There were 32 low-grade lesions and 28 high-grade lesions. Average maximal lengths of low- and high-grade tumors were 7.7 and 15.0 cm, respectively. A cleavage plane was present in 20 (62%) low-grade and 19 (68%) high-grade lesions. On cross-sectional images, intramedullary extension was present in 13 (41%) low-grade and 14 (50%) high-grade lesions. A focal soft-tissue mass distinct from the ossific matrix was identified in 25 (89%) high-grade lesions and in only two (6%) low-grade lesions. All 17 high-grade lesions evaluated with MR imaging were of predominantly high signal intensity on T2-weighted images.
  
  
  CONCLUSIONS
  A poorly defined soft-tissue component distinct from the ossific matrix is the most distinctive feature of high-grade parosteal osteosarcoma and may be an optimal site for biopsy.
authors.affiliation: Department of Radiology, Washington Cancer Institute, Washington, DC 20010, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Jelinek
authors.forename: M D
authors.initials: MD
authors.lastname: Murphey
authors.forename: M J
authors.initials: MJ
authors.lastname: Kransdorf
authors.forename: B M
authors.initials: BM
authors.lastname: Shmookler
authors.forename: M M
authors.initials: MM
authors.lastname: Malawer
authors.forename: R C
authors.initials: RC
authors.lastname: Hur
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D005266:Femoral Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D006811:Humerus; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018217:Osteosarcoma, Juxtacortical / Q000000981:diagnostic imaging* / Q000473:pathology*; D012189:Retrospective Studies; D013977:Tibia; D014057:Tomography, X-Ray Computed