Mechanism of interferon action sequence of the human interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones.
The pkr gene encoding the interferon-inducible, RNA-dependent protein kinase was isolated as lambda phage and P1 phage clones from human genomic DNA and characterized by restriction mapping, Southern blot analysis, and nucleotide sequencing. The genomic nucleotide sequence, when compared to that of previously determined cDNA sequences, revealed 17 exons encoding the 551-amino-acid PKR protein. We report herein the sequence of the human PKR protein kinase deduced from genomic clones.
Kuhen
K L
KL
Interdepartmental Graduate Program of Biochemistry and Molecular Biology, University of California, Santa Barbara 93106, USA.
Shen
X
X
Samuel
C E
CE
D000595:Amino Acid Sequence; D001483:Base Sequence; D005091:Exons; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D008969:Molecular Sequence Data; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D019892:eIF-2 Kinase
D007372:Interferons; D017346:Protein Serine-Threonine Kinases; D019892:eIF-2 Kinase