[Experimental models in research of the pathomechanism of diabetes mellitus].
The authors review the knowledge accumulated on animal models of diabetes during the last decade. The most commonly used diabetes models and the underlying disease processes are summarized, respectively. The best known diabetogenic substances, Streptozotocin and Alloxan are described, including their usage, dosage dosing intervals, and mechanism of action. The latest results are included in the article which discuss the possible role of free radical-induced injury of beta cells in Streptozotocin and Alloxan diabetes.
Pusztai
P
P
II. Belgyógyászati Klinika, Semmelweis Orvostudományi Egyetem, Budapest.
Prechl
J
J
Somogyi
A
A
Szaleczky
E
E
Fehér
J
J
D000496:Alloxan / Q000494:pharmacology; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000503:physiopathology; D003922:Diabetes Mellitus, Type 1 / Q000139:chemically induced; D004195:Disease Models, Animal; D005609:Free Radicals / Q000494:pharmacology; D006801:Humans; D051379:Mice; D016688:Mice, Inbred NOD; D051381:Rats; D011913:Rats, Inbred BB; D013311:Streptozocin / Q000494:pharmacology
D005609:Free Radicals; D013311:Streptozocin; D000496:Alloxan