[The monitoring of protein-volemic indices during plasmapheresis in patients with paraproteinemic hemoblastoses].
We studied quantitative characteristics of plasma protein before, during and after 133 plasmapheresis (PA) procedures in patients with multiple myeloma and Waldenstrom's macroglobulinemia. A value of removed plasma volume (RPV) was calculated as a part plasma volume (PV) before PA with consideration of quantity and consequence of replacement solution. In the case when we removed 30% of calculated PV we replaced it only with electrolyte solutions. In the case of 50% PV removing, the replacement was a combination of low molecular weight dextran and electrolyte solutions (1:2) or 5% albumin and electrolyte solutions. The results support correlation between a level of total protein and RPV, kind of replacement solutions. We recommend two regression equations for efficient and safety planning RPV and for prediction of protein level after PA. This simple and fast method can be used for prognosis of critic PA parameters, to decrease a risk of side effects and for optimal use of albumin replacement solutions.
Kalinin
N N
NN
Movshev
B E
BE
Petrov
M M
MM
Petrova
V I
VI
Droshneva
V A
VA
Varlamova
S V
SV
Khoroshko
N D
ND
Zhuravlev
V S
VS
Loginov
S P
SP
D001798:Blood Proteins / Q000032:analysis*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D046911:Macromolecular Substances; D008297:Male; D008991:Monitoring, Physiologic; D009101:Multiple Myeloma / Q000097:blood / Q000503:physiopathology / Q000628:therapy; D010265:Paraproteinemias / Q000097:blood* / Q000503:physiopathology / Q000628:therapy*; D010953:Plasma Volume; D010956:Plasmapheresis / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D011379:Prognosis; D012044:Regression Analysis; D008258:Waldenstrom Macroglobulinemia / Q000097:blood / Q000503:physiopathology / Q000628:therapy
D001798:Blood Proteins; D046911:Macromolecular Substances