title: Studies on penam sulfones. I. Synthesis and beta-lactamase inhibitory activity of 2 beta-alkoxycarbonyl penicillanic acid sulfones.
authors.affiliation: SynPhar Laboratories Inc., Edmonton, Alberta, Canada.
authors.forename: E L
authors.initials: EL
authors.lastname: Setti
authors.forename: N A
authors.initials: NA
authors.lastname: Reddy
authors.forename: O A
authors.initials: OA
authors.lastname: Phillips
authors.forename: D P
authors.initials: DP
authors.lastname: Czajkowski
authors.forename: K
authors.initials: K
authors.lastname: Atchison
authors.forename: H
authors.initials: H
authors.lastname: Atwal
authors.forename: R G
authors.initials: RG
authors.lastname: Micetich
authors.forename: S N
authors.initials: SN
authors.lastname: Maiti
authors.forename: C
authors.initials: C
authors.lastname: Kunugita
authors.forename: A
authors.initials: A
authors.lastname: Hyodo
mesh_terms: D002442:Ceftazidime / Q000494:pharmacology; D004357:Drug Synergism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010878:Piperacillin / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000737:chemistry; D000078142:Tazobactam; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000187:drug effects / Q000378:metabolism
chemical_list: C102436:2-(ethoxycarbonyl)-6,6-dihydropenicillanic acid; D004791:Enzyme Inhibitors; D013450:Sulfones; D065093:beta-Lactamase Inhibitors; D010397:Penicillanic Acid; D002442:Ceftazidime; D001618:beta-Lactamases; C034413:beta-lactamase TEM-1; D000078142:Tazobactam; D010878:Piperacillin