When viral serological testing is not enough: diagnosing disease in vaccinated animals.
Serological testing can be a key factor in diagnosing viral diseases. However, the extensive use of vaccines in companion animals can severely limit the use antibody detection testing. Modified-live vaccines induce an immune response that is indistinguishable from street virus in the antibody pattern and time course. Alternative testing schemes may be needed to assist the practitioner in arriving at a valid diagnosis.
Dubovi
E J
EJ
Diagnostic Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
D000818:Animals; D000956:Antigens, Viral / Q000302:isolation & purification*; D002371:Cat Diseases / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D002415:Cats; D004283:Dog Diseases / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D004285:Dogs; D012698:Serologic Tests / Q000662:veterinary*; D014611:Vaccination / Q000662:veterinary*; D014777:Virus Diseases / Q000175:diagnosis / Q000662:veterinary*
D000956:Antigens, Viral