title: [Clinical trial of the effects of isodibut on several indicators of microcirculation in combined therapy of patients with diabetes mellitus].
abstract: The authors have tried a new drug isodibut, aldoreductase inhibitor, of Russian produce in 53 patients with diabetes mellitus. A course of isodibut++ has improved blood coagulation and fibrinolysis, microcirculatory blood flow, normalized muscular blood flow as indicated by electrocoagulation, conjunctival biomicroscopy, radionuclide tracing. The drug is recommended for treatment and prevention of diabetic angiopathy.
authors.forename: I M
authors.initials: IM
authors.lastname: Kakhnovskiĭ
authors.forename: T V
authors.initials: TV
authors.lastname: Koroleva
authors.forename: G A
authors.initials: GA
authors.lastname: Golubiatnikova
authors.forename: M A
authors.initials: MA
authors.lastname: Kalinkina
mesh_terms: D000328:Adult; D000368:Aged; D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D001777:Blood Coagulation / Q000187:drug effects; D003228:Conjunctiva / Q000098:blood supply; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000503:physiopathology; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000517:prevention & control*; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007546:Isoquinolines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D008875:Middle Aged; D009132:Muscles / Q000098:blood supply
chemical_list: D004791:Enzyme Inhibitors; D007004:Hypoglycemic Agents; D007546:Isoquinolines; C053669:isodibut; D000449:Aldehyde Reductase