title: Natural history and prognosis of untreated stage I epithelial ovarian carcinoma.
abstract: OBJECTIVE
  The aim of this study was to investigate the independent significance of prognostic factors in stage I invasive epithelial ovarian cancer (EOC).
  
  
  METHODS
  Between 1980 and 1994, all patients with stage I EOC (borderline tumors excluded) following surgical resection were entered onto this study. No patient received adjuvant therapy and patients were monitored as follows: years 1 to 2-physical examination and serum CA125 every 3 months and computed tomographic (CT) scan every 6 months; years 3 to 5-physical examination and serum CA125 every 6 months and CT scan yearly; years 5 to 10-annual physical examination and serum CA125, with CT scan if clinically indicated.
  
  
  RESULTS
  A total of 194 patients entered the study. The median patient age was 54 years (range, 15 to 83), and the median follow-up duration 54 months (range, 7 to 157). Five-year survival rates were as follows: stage IA, 93.7%; stage IB, 92%; and stage IC, 84%. Multivariate analysis using Cox's regression identified grade (P < .001), presence of ascites (P = .05), and surface tumor (P < .01) as independent poor prognostic factors. International Federation of Gynecology and Obstetrics (FIGO) substage did not appear to have independent prognostic significance. Intraoperative capsule rupture was not found to be prognostically significant. The impact of pre-operative rupture remains unclear.
  
  
  CONCLUSIONS
  This is an important series, as no patient received adjuvant therapy, and represents the natural history of surgically resected stage I EOC.
authors.affiliation: Gynaecology Unit, Royal Marsden Hospital, London, United Kingdom.
authors.forename: F Y
authors.initials: FY
authors.lastname: Ahmed
authors.forename: E
authors.initials: E
authors.lastname: Wiltshaw
authors.forename: R P
authors.initials: RP
authors.lastname: A'Hern
authors.forename: B
authors.initials: B
authors.lastname: Nicol
authors.forename: J
authors.initials: J
authors.lastname: Shepherd
authors.forename: P
authors.initials: P
authors.lastname: Blake
authors.forename: C
authors.initials: C
authors.lastname: Fisher
authors.forename: M E
authors.initials: ME
authors.lastname: Gore
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000175:diagnosis / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D011379:Prognosis; D015996:Survival Rate