title: Recognition of immunoglobulin A1 by oral actinomyces and streptococcal lectins.
abstract: Actinomyces naeslundii and Streptococcus gordonii, oral bacteria that possess Gal/GalNAc- and sialic acid-reactive lectins, respectively, were adherent to immobilized secretory immunoglobulin A (IgA) and two IgA1 myeloma proteins but not to two IgA2 myeloma proteins. Apparently, O-linked oligosaccharides at the hinge region of the IgA1 heavy chain are receptors for lectin-mediated adhesion of these bacteria.
authors.affiliation: Laboratory of Microbial Ecology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: S
authors.initials: S
authors.lastname: Ruhl
authors.forename: A L
authors.initials: AL
authors.lastname: Sandberg
authors.forename: M F
authors.initials: MF
authors.lastname: Cole
authors.forename: J O
authors.initials: JO
authors.lastname: Cisar
mesh_terms: D000190:Actinomyces / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D037102:Lectins / Q000276:immunology*; D009055:Mouth / Q000382:microbiology; D009194:Myeloma Proteins / Q000276:immunology*; D013291:Streptococcus / Q000276:immunology*
chemical_list: D007070:Immunoglobulin A; D037102:Lectins; D009194:Myeloma Proteins