The emerging role of MIF in septic shock and infection.
The protein mediator described originally as macrophage migration inhibitory factor (MIF) has been "re-discovered" recently to be both a novel pituitary hormone and a pro-inflammatory, macrophage-derived cytokine. Emerging studies indicate that MIF plays a pivotal role not only in endotoxic shock but also in the host response to a variety of acute and chronic infections.
Bernhagen
J
J
Picower Institute for Medical Research, Manhassett, New York 11030, USA.
Calandra
T
T
Bucala
R
R
D000818:Animals; D006801:Humans; D007239:Infections / Q000503:physiopathology*; D008263:Macrophage Migration-Inhibitory Factors / Q000502:physiology*; D012772:Shock, Septic / Q000503:physiopathology*
D008263:Macrophage Migration-Inhibitory Factors