title: Contact allergy to the active ingredients of Bioban P 1487.
abstract: Bioban P 1487, consisting of the 2 active ingredients 4-(2-nitrobutyl)-morpholine (M) and 4,4'-(2-ethyl-2-nitro-1,3-propanediyl)-bis morpholine (DM), is a preservative recommended for mental working fluids. The aims of this study were to assess the frequency of contact allergy to Bioban P 1487, when added to a standard patch test series, as well as to test the individual active ingredients in patients sensitized to Bioban P 1487. Of the patients consecutively tested, 1.5% reacted positively to Bioban P 1487. Positive test reactions were noted in only 4 of 12 Bioban P 1487-sensitized patients tested with the individual active ingredients. Both active ingredients are contact sensitizers, but in most patients with this contact allergy it remains difficult to identify the sensitizing hapten.
authors.affiliation: Department of Occupational and Environmental Dermatology, University Hospital, Malmö, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Gruvberger
authors.forename: M
authors.initials: M
authors.lastname: Bruze
authors.forename: E
authors.initials: E
authors.lastname: Zimerson
mesh_terms: D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D005557:Formaldehyde / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry; D006241:Haptens / Q000009:adverse effects / Q000032:analysis; D006801:Humans; D008669:Metallurgy; D008970:Molecular Weight; D009025:Morpholines / Q000009:adverse effects* / Q000032:analysis / Q000737:chemistry; D010328:Patch Tests; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects* / Q000032:analysis / Q000737:chemistry
chemical_list: D006241:Haptens; D009025:Morpholines; D011310:Preservatives, Pharmaceutical; D005557:Formaldehyde; C040955:P 1487