The intron-exon structure of the porcine E-selectin-encoding gene.
We have cloned and sequenced the gene encoding porcine E-selectin. The gene comprises 12 exons and 11 introns. Two pseudoexons are contained within intron 4 and intron 6. These sequences are similar to the corresponding exons in the human E-selectin sequence; however, they are not present in the porcine E-selectin-encoding cDNA. Transcription starts at position -498 relative to the translation initiation site. The first ATG is located within exon 2. Translation stops in exon 11 leaving exon 12 untranslated in its entirety.
Winkler
H
H
Sandoz Center for Immunobiology, New England Deaconess Hospital, Harvard Medical School, Boston, MA 02215, USA. hwinkler@nedhmail.nedh.harvard.edu
Brostjan
C
C
Csizmadia
V
V
Natarajan
G
G
Anrather
J
J
Bach
F H
FH
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018076:DNA, Complementary; D019040:E-Selectin / Q000235:genetics*; D005091:Exons; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D013552:Swine
D018076:DNA, Complementary; D019040:E-Selectin