title: Vitamin C status and serum lipids.
abstract: OBJECTIVE
  To examine the cross sectional relationship between plasma vitamin C and serum lipids.
  
  
  METHODS
  Cross-sectional analysis.
  
  
  METHODS
  Population based study.
  
  
  METHODS
  835 Men and 1025 women aged 45-75 registered with GP practices in Norfolk.
  
  
  METHODS
  Completion of health and lifestyle questionnaire and attendance for a health check.
  
  
  METHODS
  Non fasting plasma vitamin C and serum lipids.
  
  
  RESULTS
  Plasma vitamin C was not correlated with serum total cholesterol or LDL cholesterol in men or women. In women plasma vitamin C was positively correlated with HDL cholesterol r = 0.15 (P < 0.001) and negatively correlated with triglyceride r = -0.17 P < 0.001). These correlations persisted after adjustment for age and body mass index. The association in men was weaker and after adjustment for age and body mass index was no longer statistically significant. Exclusion of subjects taking vitamin supplements and those with known hyperlipidaemic did not affect the findings. The difference in HDL cholesterol, adjusted for age, body mass index and alcohol intake, for a 50 micromol/l difference in vitamin C, estimated using linear regression, was 0.11 mmol/l in women. The difference in triglyceride, adjusted for age and body mass index was -0.16 mmol/l in women.
  
  
  CONCLUSIONS
  Plasma vitamin C level may be a marker of other factors; nevertheless these results are consistent with other published work indicating that a high intake of vitamin C from food raises serum HDL cholesterol and lowers serum triglyceride.
authors.affiliation: Wellcome Training Fellow in Epidemiology, Institute of Public Health, University Forvie Site, Cambridge.
authors.forename: A R
authors.initials: AR
authors.lastname: Ness
authors.forename: K T
authors.initials: KT
authors.lastname: Khaw
authors.forename: S
authors.initials: S
authors.lastname: Bingham
authors.forename: N E
authors.initials: NE
authors.lastname: Day
mesh_terms: D000368:Aged; D001205:Ascorbic Acid / Q000097:blood*; D002784:Cholesterol / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011795:Surveys and Questionnaires; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D002784:Cholesterol; D001205:Ascorbic Acid