title: GMP reverses the facilitatory effect of glutamate on inhibitory avoidance task in rats.
abstract: Previous studies have demonstrated that post-training intrahippocampal glutamate administration improves inhibitory avoidance task performance in rats. Antagonism of the agonist actions of glutamate by guanine nucleotides has been shown at the molecular and behavioural level. In the present investigation we demonstrate that intrahippocampal co-administration of GMP (guanosine 5'-monophosphate) reverses the facilitatory effect of glutamate on the inhibitory avoidance learning paradigm and inhibits [3H]glutamate binding in hippocampal synaptic plasma membranes. These results suggest that guanine nucleotides may modulate glutamate actions.
authors.affiliation: Departamento de Quimica, Universidade Federal de Santa Maria, Brasil.
authors.forename: M A
authors.initials: MA
authors.lastname: Rubin
authors.forename: A
authors.initials: A
authors.lastname: Jurach
authors.forename: E M
authors.initials: EM
authors.lastname: da Costa Júnior
authors.forename: T T
authors.initials: TT
authors.lastname: Lima
authors.forename: R E
authors.initials: RE
authors.lastname: Jiménez-Bernal
authors.forename: J
authors.initials: J
authors.lastname: Begnini
authors.forename: D O
authors.initials: DO
authors.lastname: Souza
authors.forename: C F
authors.initials: CF
authors.lastname: de Mello
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D018698:Glutamic Acid / Q000378:metabolism / Q000494:pharmacology*; D006157:Guanosine Monophosphate / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013570:Synaptic Membranes / Q000187:drug effects / Q000378:metabolism
chemical_list: D018698:Glutamic Acid; D006157:Guanosine Monophosphate