title: Complications after treatment of cervical intraepithelial neoplasia in women infected with the human immunodeficiency virus.
abstract: OBJECTIVE
  To compare the frequency of complications after treatment of cervical intraepithelial neoplasia (CIN) in human immunodeficiency virus (HIV)-infected and -seronegative women in an ambulatory setting.
  
  
  METHODS
  A retrospective record review of 15 HIV-infected and 44 HIV-negative women treated by laser therapy or cone biopsy and retrospective interviews of 20 HIV-infected and 44 HIV-negative women treated by cryotherapy.
  
  
  RESULTS
  Four of 35 (11%) HIV-infected women had excessive bleeding after laser/cone or cryotherapy as compared to one of 88 (1%) HIV-negative women (odds ratio 11.27, P = .02). After laser/cone therapy, significantly more HIV-infected women (53%) had cervicovaginal infections than did HIV-negative women (18%). A higher prevalence of infection was associated with more severe immunodeficiency.
  
  
  CONCLUSIONS
  HIV-infected women are vulnerable to complications after treatment of CIN and should be monitored closely.
authors.affiliation: Department of Obstetrics and Gynecology, State University of New York, Brooklyn, NY 11203, USA.
authors.forename: S
authors.initials: S
authors.lastname: Cuthill
authors.forename: M
authors.initials: M
authors.lastname: Maiman
authors.forename: R G
authors.initials: RG
authors.lastname: Fruchter
authors.forename: I
authors.initials: I
authors.lastname: Lopatinsky
authors.forename: C C
authors.initials: CC
authors.lastname: Cheng
mesh_terms: D003452:Cryosurgery / Q000009:adverse effects; D005260:Female; D015658:HIV Infections / Q000150:complications*; D018023:HIV Seronegativity; D006801:Humans; D053685:Laser Therapy / Q000009:adverse effects; D016017:Odds Ratio; D019106:Postoperative Hemorrhage / Q000209:etiology*; D015995:Prevalence; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000209:etiology*; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000150:complications / Q000601:surgery*