title: The effect of chronic carbamazepine, valproic acid and phenytoin medication on the periodontal condition of epileptic children and adolescents.
abstract: Periodontal condition was studied in 84 epileptic 8-18 year-old patients who had been undergoing antiepileptic drug (AEP) treatment for a period of at least 3 years. They were diagnosed as suffering from partial seizures (simplex or complex) or general tonic-clonic fits and were treated with therapeutic oral doses of phenytoin (PHT) and carbamazepine (CBZ) or valproic acid (VPA) in mono- or polytherapy. All patients received a drug dosage to ensure adequate plasma concentration and satisfactory seizure control. The Gingival Index (GI), Sulcus Bleeding Index (SBI) and Plaque Index (Pl-I) were individually scored. The control group contained 30 age-matched healthy children and adolescents. The GI and SBI indices were higher in epileptics than in controls. Only the Pl-I was similar in both groups. Gingival enlargement was found in 30% of the epileptic patients. There was no definite plasma concentration-dependent increase in the incidence of gingival overgrowth.
authors.affiliation: Department of Developmental Neurology, University of Medical Sciences, Poznań, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Galas-Zgorzalewicz
authors.forename: M
authors.initials: M
authors.lastname: Borysewicz-Lewicka
authors.forename: M
authors.initials: M
authors.lastname: Zgorzalewicz
authors.forename: E
authors.initials: E
authors.lastname: Borowicz-Andrzejewska
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D002220:Carbamazepine / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D002648:Child; D004828:Epilepsies, Partial / Q000188:drug therapy*; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy*; D005891:Gingivitis / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D010672:Phenytoin / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D014635:Valproic Acid / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine; D014635:Valproic Acid; D010672:Phenytoin