title: Design, synthesis, and evolution of a novel, selective, and orally bioavailable class of thrombin inhibitors: P1-argininal derivatives incorporating P3-P4 lactam sulfonamide moieties.
authors.affiliation: Corvas International, Inc., San Diego, California 92121-1102, USA. ed_semple@corvas.com
authors.forename: J E
authors.initials: JE
authors.lastname: Semple
authors.forename: D C
authors.initials: DC
authors.lastname: Rowley
authors.forename: T K
authors.initials: TK
authors.lastname: Brunck
authors.forename: T
authors.initials: T
authors.lastname: Ha-Uong
authors.forename: N K
authors.initials: NK
authors.lastname: Minami
authors.forename: T D
authors.initials: TD
authors.lastname: Owens
authors.forename: S Y
authors.initials: SY
authors.lastname: Tamura
authors.forename: E A
authors.initials: EA
authors.lastname: Goldman
authors.forename: D V
authors.initials: DV
authors.lastname: Siev
authors.forename: R J
authors.initials: RJ
authors.lastname: Ardecky
authors.forename: S H
authors.initials: SH
authors.lastname: Carpenter
authors.forename: Y
authors.initials: Y
authors.lastname: Ge
authors.forename: B M
authors.initials: BM
authors.lastname: Richard
authors.forename: T G
authors.initials: TG
authors.lastname: Nolan
authors.forename: K
authors.initials: K
authors.lastname: Håkanson
authors.forename: A
authors.initials: A
authors.lastname: Tulinsky
authors.forename: R F
authors.initials: RF
authors.lastname: Nutt
authors.forename: W C
authors.initials: WC
authors.lastname: Ripka
mesh_terms: D000818:Animals; D000991:Antithrombins / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D001120:Arginine / Q000737:chemistry*; D001682:Biological Availability; D004285:Dogs; D015195:Drug Design; D007769:Lactams / Q000737:chemistry*; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000991:Antithrombins; D007769:Lactams; D001120:Arginine