N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.
Chronic fatigue syndrome is a heterogeneous condition with as proves effective treatment. I present two case reports in which N of 1 trials helped me make management decisions. High-dose vitamin B12 injections were ineffective in one case; nimodipine was very effective in the other case.
Wiebe
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Department of Family Practice, University of British Columbia, Vancouver.
D000328:Adult; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D018592:Cross-Over Studies; D003661:Decision Support Techniques; D004311:Double-Blind Method; D015673:Fatigue Syndrome, Chronic / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009553:Nimodipine / Q000627:therapeutic use*; D014805:Vitamin B 12 / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D009553:Nimodipine; D014805:Vitamin B 12