title: Structure-activity relationships of some 1,4-benzodioxane aryl-piperazine derivatives as alpha-blocking agents.
abstract: The synthesis of eight novel 1,4-benzodioxane derivatives is reported. The blocking activity of these compounds was determined on the pre- and postsynaptic alpha-adrenoceptors of isolated rat vas deferens. Structure-activity relationships are discussed.
authors.affiliation: Istituto di Chimica e Tecnologia del Farmaco, Università di Perugia, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Corsano
authors.forename: G
authors.initials: G
authors.lastname: Strappaghetti
authors.forename: R
authors.initials: R
authors.lastname: Scapicchi
authors.forename: G
authors.initials: G
authors.lastname: Marucci
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D004146:Dioxanes / Q000138:chemical synthesis* / Q000494:pharmacology*; D008297:Male; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000317:Adrenergic alpha-Antagonists; D004146:Dioxanes; D010879:Piperazines