title: Entomophthoramycosis: therapeutic success by using amphotericin B and terbinafine.
abstract: A 12-year-old girl had been presenting a woody infiltration and erythema in the frontal region and on the entire left half of the face, leading to deformity of the nose and buccal fissure, and adenomegaly in a posterior cervical chain, for the last 18 months. Sinusitis was diagnosed and treated with antibiotics, and submitted to ethmoid sinusotomy, with no improvement. Several laboratory tests were made to find the correct diagnosis. An intradermal test for delayed hypersensitivity showed a positive reaction (5 mm) with necrosis for metabolic antigens for Conidiobolus. An oral mucosa biopsy showed a dense lymphohistiocytic infiltrate and focal points of necrosis. Gomori staining for fungi revealed countless wide, nonseptate hyphae. Amphotericin B was prescribed during 35 days, with no improvement. Terbinafine given orally was started in association with amphotericin B. Reduction of the lesions was observed 2 months later. No side effects were seen during 4 months of treatment.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil.
authors.forename: N T
authors.initials: NT
authors.lastname: Foss
authors.forename: M R
authors.initials: MR
authors.lastname: Rocha
authors.forename: V T
authors.initials: VT
authors.lastname: Lima
authors.forename: M A
authors.initials: MA
authors.lastname: Velludo
authors.forename: A M
authors.initials: AM
authors.lastname: Roselino
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000946:Antigens, Fungal / Q000032:analysis; D002648:Child; D003881:Dermatomycoses / Q000175:diagnosis / Q000188:drug therapy*; D004338:Drug Combinations; D004773:Entomophthora / Q000276:immunology; D004890:Erythema / Q000382:microbiology; D015521:Ethmoid Sinusitis / Q000175:diagnosis / Q000188:drug therapy; D005148:Facial Dermatoses / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D006801:Humans; D008206:Lymphatic Diseases / Q000382:microbiology; D009059:Mouth Diseases / Q000382:microbiology; D009281:Naphthalenes / Q000008:administration & dosage / Q000627:therapeutic use*; D009668:Nose Diseases / Q000382:microbiology; D000077291:Terbinafine
chemical_list: D000935:Antifungal Agents; D000946:Antigens, Fungal; D004338:Drug Combinations; D009281:Naphthalenes; D000666:Amphotericin B; D000077291:Terbinafine