Cytotoxic triterpenes from a marine sponge, Stelletta sp.
Bioassay-guided fractionation of an extract of a marine sponge, Stelletta sp., has led to the isolation and characterization of four new cytotoxic isomalabaricane triterpenes, named stellettins C (1), D (2), E (3), and F (4). Three known triterpenes (5-7) were also isolated from the same extract. The most sensitive of the tested cell lines (e.g., leukemia, central nervous system, renal) generally responded with GI50 concentrations in the low-to-mid nanomolar range.
McCormick
J L
JL
Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
McKee
T C
TC
Cardellina
J H
JH
Leid
M
M
Boyd
M R
MR
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D014315:Triterpenes