Neuronal progenitors as tools for cell replacement in the nervous system.
The clinical prospect of using neural precursor cells for reconstructive approaches in the nervous system has received strong impetus from a recent series of important experimental findings. Transplantation studies in the developing brain have demonstrated that migration and differentiation of neural precursor cells are regulated predominantly by environmental signals. Several observations suggest that the mature CNS retains at least some of these guidance cues. These findings, together with recent evidence for the persistence of neural stem cells in the adult mammalian brain, have made precursor cell recruitment a new focus in CNS reconstruction.
Brüstle
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Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-4092, USA. brustle@codon.nih.gov
McKay
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D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology*; D002454:Cell Differentiation; D002470:Cell Survival; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008322:Mammals; D009416:Nerve Regeneration; D009473:Neuronal Plasticity; D009474:Neurons / Q000502:physiology* / Q000637:transplantation*; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology*; D014183:Transplantation, Heterologous