title: An age-dependent novel hyperinnervation of circumvallate papillae by tyrosine hydroxylase-containing nerve fibers in NGF-overexpressing transgenic mice.
abstract: The density of protein gene product 9.5- and tyrosine hydroxylase-immunoreactive nerve fibers innervating circumvallate papillae of the tongue was substantially increased in transgenic mice that overexpressed nerve growth factor (NGF) when compared with age-matched controls. The fiber density was age-dependent. Only transgenic mice contained NGF-immunoreactive basal cells in the vicinity of taste buds, indicating that target-derived NGF induced novel hyperinnervation of the circumvallate papillae.
authors.affiliation: Department of Physiology, University of Kentucky College of Medicine, Lexington 40536-0084, USA.
authors.forename: S
authors.initials: S
authors.lastname: Takami
authors.forename: M L
authors.initials: ML
authors.lastname: Getchell
authors.forename: K M
authors.initials: KM
authors.lastname: Albers
authors.forename: T V
authors.initials: TV
authors.lastname: Getchell
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D008822:Mice, Transgenic; D009412:Nerve Fibers / Q000201:enzymology / Q000502:physiology*; D009414:Nerve Growth Factors / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D051381:Rats; D013650:Taste Buds / Q000502:physiology*; D013869:Thiolester Hydrolases / Q000096:biosynthesis; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*; D043222:Ubiquitin Thiolesterase
chemical_list: D009414:Nerve Growth Factors; D014446:Tyrosine 3-Monooxygenase; D013869:Thiolester Hydrolases; D043222:Ubiquitin Thiolesterase