title: Serum levels of articaine 2% and 4% in children.
abstract: The results of the present study of the pharmacokinetics of articaine in children show serum concentrations comparable to those in adults. The maximum values are distinctly lower with the 2% articaine solution. The t max found in our investigation was distinctly earlier than in comparable investigations on adults, whereas the plasma clearance was increased. There is no need to fix a lower mg/kg articaine dose limit for children because of age-related differences in the pharmacokinetics. The use of 2% articaine in pediatric dentistry is particularly advantageous because of the lower C max and the shorter half-life.
authors.affiliation: Privatuniversität Witten, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Jakobs
authors.forename: B
authors.initials: B
authors.lastname: Ladwig
authors.forename: P
authors.initials: P
authors.lastname: Cichon
authors.forename: R
authors.initials: R
authors.lastname: Ortel
authors.forename: W
authors.initials: W
authors.lastname: Kirch
mesh_terms: D000766:Anesthesia, Dental / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics*; D002355:Carticaine / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics*; D002648:Child; D002675:Child, Preschool; D019140:Dental Care for Children / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate
chemical_list: D000779:Anesthetics, Local; D002355:Carticaine