Photochemical stability of norfloxacin in solutions, bulk form and tablets.
Accelerated photochemical degradation of norfloxacin in solutions, bulk forms, and tablets has been undertaken. The kinetic order of the drug photodegradation was determined by monitoring residual drug masses as a function of time matched with initial matched mass by adopting the HPLC-method of USP-23. A new dimeric photodegradate, formed from the active decarboxylated norfloxacin monomer, could be isolated and characterized.
al-Deeb
O A
OA
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Abdel-Moety
E M
EM
Abounassif
M A
MA
Alzaben
S R
SR
D000890:Anti-Infective Agents / Q000032:analysis*; D004355:Drug Stability; D009643:Norfloxacin / Q000032:analysis*; D010777:Photochemistry; D013607:Tablets
D000890:Anti-Infective Agents; D013607:Tablets; D009643:Norfloxacin