title: Acute in vivo studies of the Pittsburgh intravenous membrane oxygenator.
abstract: The efficacy of an innovative intravenous membrane oxygenator (IMO) was tested acutely (6-8 hrs) in seven calves. The IMO prototypes consisted of a central polyurethane balloon within a bundle of hollow fibers with a membrane surface area of 0.14 m2. The IMO devices were inserted through the external jugular vein into the inferior vena cava of anesthetized calves (68.9 +/- 2.3 kg). Rhythmic balloon pulsation (60-120 bpm) was controlled with an intra-aortic balloon pump console. Oxygen sweep gas was delivered through the device at 3.0 L/min. Gas concentrations were monitored continuously by mass spectroscopy. The principal results were as follows: 1) oxygen and carbon dioxide exchange ranged from 125 to 150 ml/min/m2 and 150 to 200 ml/min/m2, respectively; 2) there was at least a 30-50% augmentation of gas exchange with balloon pulsation; 3) maximum exchange occurred with 60-90 bpm balloon pulsations; and 4) hemodynamic parameters remained unchanged. There were no device related complications, and the feasibility of insertion of the device by a cervical cut-down was established. These acute in vivo experiments show that the Pittsburgh IMO device can exchange oxygen and carbon dioxide gases in vivo at levels consistent with this current prototype design, and that intravenous balloon pulsation significantly enhances gas exchange without causing any end-organ damage.
authors.affiliation: Department of Surgery, University of Pittsburgh, Pennsylvania 15219, USA.
authors.forename: M
authors.initials: M
authors.lastname: Macha
authors.forename: W J
authors.initials: WJ
authors.lastname: Federspiel
authors.forename: L W
authors.initials: LW
authors.lastname: Lund
authors.forename: P J
authors.initials: PJ
authors.lastname: Sawzik
authors.forename: P
authors.initials: P
authors.lastname: Litwak
authors.forename: F R
authors.initials: FR
authors.lastname: Walters
authors.forename: G D
authors.initials: GD
authors.lastname: Reeder
authors.forename: H S
authors.initials: HS
authors.lastname: Borovetz
authors.forename: B G
authors.initials: BG
authors.lastname: Hattler
mesh_terms: D000328:Adult; D000818:Animals; D001698:Biomedical Engineering; D002245:Carbon Dioxide; D002417:Cattle; D004867:Equipment Design; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D010100:Oxygen; D010107:Oxygenators, Membrane; D011659:Pulmonary Gas Exchange; D012128:Respiratory Distress Syndrome / Q000628:therapy
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen