title: Phase II study of 5-fluorouracil and leucovorin in recurrent primary brain tumor.
abstract: Thirty patients with recurrent primary brain tumors were treated with a combination of 5-fluorouracil and leucovorin. There were three responses seen. Toxicity consisted of stomatitis, diarrhea, and hematological suppression. 5-fluorouracil and leucovorin would appear to be minimally effective in recurrent brain tumors.
authors.affiliation: Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: T L
authors.initials: TL
authors.lastname: Cascino
authors.forename: M H
authors.initials: MH
authors.lastname: Veeder
authors.forename: J C
authors.initials: JC
authors.lastname: Buckner
authors.forename: J R
authors.initials: JR
authors.lastname: O'Fallon
authors.forename: M
authors.initials: M
authors.lastname: Wiesenfeld
authors.forename: R
authors.initials: R
authors.lastname: Levitt
authors.forename: R M
authors.initials: RM
authors.lastname: Goldberg
authors.forename: S A
authors.initials: SA
authors.lastname: Kuross
authors.forename: R F
authors.initials: RF
authors.lastname: Morton
authors.forename: B W
authors.initials: BW
authors.lastname: Scheithauer
mesh_terms: D000328:Adult; D000368:Aged; D000931:Antidotes / Q000627:therapeutic use* / Q000633:toxicity; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use* / Q000633:toxicity; D001254:Astrocytoma / Q000188:drug therapy*; D001932:Brain Neoplasms / Q000188:drug therapy*; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use* / Q000633:toxicity; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use* / Q000633:toxicity; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009837:Oligodendroglioma / Q000188:drug therapy*; D012008:Recurrence; D013280:Stomatitis / Q000139:chemically induced; D013921:Thrombocytopenia / Q000139:chemically induced
chemical_list: D000931:Antidotes; D000964:Antimetabolites, Antineoplastic; D002955:Leucovorin; D005472:Fluorouracil