title: Dietary trans-fatty acids and serum lipoproteins in humans.
abstract: Trans-fatty acids increase serum LDL-cholesterol and decrease HDL-cholesterol levels in humans when substituted for cis unsaturated fatty acids in the diet. Trans-fatty acids also increase lipoprotein (a) levels relative to other fatty acids. The effects on LDL and HDL may be mediated by the cholesteryl ester transfer protein.
authors.affiliation: Wageningen Agricultural University, The Netherlands.
authors.forename: P L
authors.initials: PL
authors.lastname: Zock
authors.forename: R P
authors.initials: RP
authors.lastname: Mensink
mesh_terms: D002352:Carrier Proteins / Q000378:metabolism; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D018849:Controlled Clinical Trials as Topic; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D006023:Glycoproteins; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*
chemical_list: C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004042:Dietary Fats, Unsaturated; D006023:Glycoproteins; D017270:Lipoprotein(a)