title: Angioscopic predictors of early adverse outcome after coronary angioplasty in patients with unstable angina and non-Q-wave myocardial infarction.
abstract: BACKGROUND
  Clinical and angiographic criteria have a limited ability to predict adverse outcome in patients with unstable angina who are undergoing percutaneous transluminal coronary angioplasty (PTCA). We investigated whether the use of angioscopy can improve prediction of early adverse outcome after PTCA.
  
  
  RESULTS
  Angioscopic characterization of the culprit lesion was performed before PTCA in 32 patients with unstable angina and 10 with non-Q-wave infarction. Seven patients (17%) had an adverse outcome (myocardial infarction, repeat PTCA, or need for coronary artery bypass graft surgery) within 24 hours after PTCA. Six of 18 patients with a yellow culprit lesion had an adverse outcome compared with 1 of 24 in whom the culprit lesion was white (P = .03). Six of 20 patients with plaque disruption suffered an adverse outcome compared with 1 of 22 with nondisrupted plaques (P = .04). Six of 17 patients with intraluminal thrombus had an adverse outcome, whereas only 1 of 25 patients without thrombus suffered an adverse outcome (P = .01). Yellow color, disruption, and thrombus at the culprit lesion site were associated with an eightfold increase in risk of adverse outcome after PTCA. The prediction of PTCA outcome based on characteristics of the plaque that were identifiable by angioscopy was superior to that estimated by the use of angiographic variables.
  
  
  CONCLUSIONS
  In patients with unstable angina and non-Q-wave infarction, angioscopic features of disruption, yellow color, or thrombus at the culprit lesion site can identify patients at high risk of early adverse outcome after PTCA. Angioscopy was superior to angiography for prediction of PTCA outcome.
authors.affiliation: Institute for Prevention of Cardiovascular Disease, Boston, Mass, USA.
authors.forename: S
authors.initials: S
authors.lastname: Waxman
authors.forename: M A
authors.initials: MA
authors.lastname: Sassower
authors.forename: M A
authors.initials: MA
authors.lastname: Mittleman
authors.forename: S
authors.initials: S
authors.lastname: Zarich
authors.forename: A
authors.initials: A
authors.lastname: Miyamoto
authors.forename: K S
authors.initials: KS
authors.lastname: Manzo
authors.forename: J E
authors.initials: JE
authors.lastname: Muller
authors.forename: G S
authors.initials: GS
authors.lastname: Abela
authors.forename: R W
authors.initials: RW
authors.lastname: Nesto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000473:pathology* / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary; D017546:Angioscopy; D017023:Coronary Angiography; D005260:Female; D005544:Forecasting; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology* / Q000628:therapy*; D016896:Treatment Outcome