Influence of underfeeding on the spontaneous contraction and on metabolism of labelled arachidonic acid in uteri isolated from intact and ovariectomized rats.
The effects of restricted diet (50% of the normal intake during 25 days) on the isometric developed tension (IDT), and on the metabolism of labelled arachidonic acid in uteri from intact and spayed (25 days) rats, were studied. Underfeeding produced a fall in the contractile activity of intact rats, while in ovariectomized rats contractile activity increased. Indomethacin reduced uterine contractile activity in all the cases under study. The metabolism of arachidonic acid into different eicosanoids, PGE2, PGF2 alpha, 6-keto-F1 alpha, and TXB2, showed that the restricted diet diminished PGE2 and PGF2 alpha levels in intact rats significantly. The reduction in uterine contractile activity and reduced levels of the arachidonic acid metabolites, PGE2 and PGF2 alpha, were not seen in ovariectomized animals.
Casalino
S M
SM
Cátedra de Fisiología, Facultad de Odontologia, Universidad Nacional de Córdoba, Ciudad Universitaria, Argentina.
Linares
J A
JA
Goldraij
A
A
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism*; D004031:Diestrus / Q000502:physiology; D015777:Eicosanoids / Q000378:metabolism; D005260:Female; D005508:Food Deprivation / Q000502:physiology*; D066298:In Vitro Techniques; D007537:Isometric Contraction; D010052:Ovariectomy; D051381:Rats; D014590:Uterine Contraction; D014599:Uterus / Q000378:metabolism*; D015431:Weight Loss
D015777:Eicosanoids; D016718:Arachidonic Acid