Intestinal calcium absorption from different calcium preparations: influence of anion and solubility.
Not only is the calcium content of a preparation significant for providing adequate calcium supplementation for the prophylaxis and therapy of osteoporosis, but also its bioavailability is of essential importance. In the present study, the bioavailability of calcium citrate and calcium lactogluconate/carbonate from a therapeutic dose (= 500 mg Ca2+) was compared in men aged between 45 and 60 years on an intra-individual basis. Calcium citrate was administered both as a solution and as a suspension to 18 healthy volunteers. Using a double-isotope method, the intestinal absorption from the three preparations was determined in randomized order at intervals of 2-4 weeks. The stable isotope 44Ca (20 mg), in highly enriched form, was added in each case to the ready-to-drink solutions and, at the same time, a sterile and pyrogen-free solution containing 5 mg of the stable isotope 42Ca was injected intravenously. The intestinal calcium absorption was then determined after 24 h on the basis of the ratio of the two isotopes in the plasma. There was a significantly higher absorption of 29% from the citrate solution than from the lactogluconate/carbonate solution (25%). Absorption from the citrate suspension was similar to that from the lactogluconate/carbonate solution. While no correlation was found between the measured values for calcium absorption from the three preparations and the plasma concentration of 1,25-dihydroxycholecalciferol, significant inverse correlations with the basal parathyroid hormone concentration were observed for the citrate and lactogluconate/ carbonate solution. The results of this study show that quantitative data on intestinal calcium absorption can be obtained without employing radioactive isotopes in humans. Moreover, they show that calcium absorption is not determined only by the solubility and the degree of ionization of the calcium salt administered, but rather that it is of a complex nature.
Hansen
C
C
Klinikum der J.W. Goethe-Universität, Frankfurt am Main, Germany.
Werner
E
E
Erbes
H J
HJ
Larrat
V
V
Kaltwasser
J P
JP
D001682:Biological Availability; D002119:Calcium Carbonate / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019355:Calcium Citrate / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002127:Calcium Isotopes; D005260:Female; D005942:Gluconates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007408:Intestinal Absorption; D007477:Ions; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000188:drug therapy / Q000517:prevention & control; D012995:Solubility
D002127:Calcium Isotopes; D005942:Gluconates; D007477:Ions; C041283:lactogluconic acid; D002119:Calcium Carbonate; D019355:Calcium Citrate