A double-blind comparison of nafarelin and leuprolide acetate for down-regulation in IVF cycles.
OBJECTIVE
To compare nafarelin (NAF) with leuprolide acetate (LA) for pituitary down-regulation in IVF cycles.


METHODS
Patients in a private IVF program who received both nasal spray and subcutaneous injections starting in the luteal phase prior to intended stimulation with any one route containing active drug in a randomized, prospective, double-blind study. Variables measured included the usual hormonal values as well as oocyte data, but not pregnancy rates, because of sample size and the heterogeneity of the study group.


RESULTS
There were no differences between the two groups in the areas studied.


CONCLUSIONS
Either NAF or LA can be used satisfactorily as an agent for pituitary down-regulation in IVF cycles.
Corson
S L
SL
Pennsylvania Reproductive Associates Pennsylvania Hospital Philadelphia, USA.
Gutmann
J N
JN
Batzer
F R
FR
Gocial
B
B
D000328:Adult; D004311:Double-Blind Method; D015536:Down-Regulation / Q000187:drug effects / Q000502:physiology*; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006728:Hormones / Q000494:pharmacology*; D006801:Humans; D016729:Leuprolide / Q000494:pharmacology*; D017274:Nafarelin / Q000494:pharmacology*; D010902:Pituitary Gland / Q000187:drug effects / Q000502:physiology*; D011446:Prospective Studies; D016896:Treatment Outcome
D006728:Hormones; D017274:Nafarelin; D016729:Leuprolide