The effects of propranolol hydrochloride singularly or in conjunction with ethanol on clotting activity in the rat.
1. This study was designed to see if propranolol hydrochloride alone or in conjunction with ethanol had any marked effect on blood coagulation. 2. Rats were given the compounds for 7 days and clotting activity measured. 3. Propranolol induced changes in coagulation, both alone and in conjunction with ethanol. 4. The data suggest that propranolol plus ethanol induce changes that could be detrimental to hemostasis to a greater degree than propranolol alone.
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Department of Obstetrics and Gynecology, Texas Tech University, Lubbock 79430, USA.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors / Q000032:analysis; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D010976:Platelet Count; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000319:Adrenergic beta-Antagonists; D001779:Blood Coagulation Factors; D000431:Ethanol; D011433:Propranolol