The blood-brain barrier: principles for targeting peptides and drugs to the central nervous system.
The presence of the blood-brain barrier (BBB), reduces the brain uptake of many drugs, peptides and other solutes from blood. Strategies for increasing the uptake of drugs and peptide-based drugs include; structural modifications to increase plasma half-life; improving passive penetration of the BBB by increasing the lipophilicity of the molecule; designing drugs which react with transporters present in the BBB; and reducing turnover and efflux from the central nervous system (CNS).
Begley
D J
DJ
Biomedical Sciences Division, King's College London, UK.
D000595:Amino Acid Sequence; D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism; D002352:Carrier Proteins / Q000493:pharmacokinetics; D006801:Humans; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry / Q000493:pharmacokinetics*
D002352:Carrier Proteins; D010455:Peptides