Time-dependent differential changes of immune function in rats exposed to chronic intermittent noise.
Noise is a highly relevant environmental and clinical stressor. Compared to most other experimental stressors, noise is a modest activator of neuroendocrine pathways that mimic the situation in human health where neuroendocrine activation by environmental stressors is often absent or difficult to establish. Little is known about the effects of noise exposure on the immune system. In the present work, the effects of a low-intensity chronic intermittent unpredictable noise regimen on various parameters of immune function was studied. Male wistar rats were exposed to a randomized noise protocol (white noise, 85 dB, 2-20 kHz) for 10 h per day, 15 min per h over a total period of 3 weeks. Control animals were exposed to ambient sound only. Immune function was monitored after 24 h, 7 days, and 21 days of noise exposure. Noise induced several significant changes in immune function in a time-dependent differential pattern involving both immunosuppression and immunoenhancement. After 24 h, serum IgM levels were increased and peripheral phagocytic activity was decreased. Splenic lymphocytic proliferation to mitogens was significantly decreased after 7 days, but slightly elevated after 3 weeks. The activity of splenic NK cells was increased significantly after 24 h and 7 days, but suppressed after 3 weeks. These results show that various parameters of immune function are affected differentially over time in a period of chronic mild noise stress, possibly due to sequential activation of different physiological mechanisms.
Van Raaij
M T
MT
National Institute of Public Health and the Environment, Laboratory of Toxicology, Utrecht University, Bilthoven, The Netherlands. MTM.van.Raaij@rivm.nl
Oortgiesen
M
M
Timmerman
H H
HH
Dobbe
C J
CJ
Van Loveren
H
H
D000818:Animals; D007136:Immunoglobulins / Q000378:metabolism*; D008214:Lymphocytes / Q000502:physiology*; D008297:Male; D009622:Noise; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000378:metabolism*; D013997:Time Factors
D007136:Immunoglobulins