title: The efficacy and cost of aprotinin in children undergoing reoperative open heart surgery.
abstract: We performed a prospective, randomized, placebo-controlled, double-blind trial to assess the efficacy of aprotinin in 61 children (median age 3.7 yr) undergoing reoperative open heart surgery (OHS). Three demographically similar groups were studied: large-dose aprotinin (ALD), small-dose aprotinin (ASD), and placebo (P). Over the first 24 postoperative hours fewer patients in the aprotinin groups received packed red cells (ALD, 53%; ASD, 89%; and P, 95%; P = 0.001), platelets (ALD, 32%; ASD, 50%; and P, 65%; P = 0.04), and fresh frozen plasma (ALD, 16%; ASD, 17%; and P, 60%; P = 0.003) than placebo patients. Most importantly, aprotinin patients had fewer exposures to banked blood components (ALD, median 1 U; and ASD, median 2 U) than P (median 6 U; P = 0.001), with no difference in overall complication rate. Use of aprotinin was associated with a savings in the patient charges for blood components, operating room time, and duration of hospitalization. In conclusion, aprotinin decreased the number of units of banked blood components used during the first 24 postoperative hours in reoperative pediatric OHS. Aprotinin thus decreases the risks associated with exposure to banked blood components and reduces hospital charges.
authors.affiliation: Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, USA.
authors.forename: C C
authors.initials: CC
authors.lastname: D'Errico
authors.forename: J R
authors.initials: JR
authors.lastname: Shayevitz
authors.forename: S J
authors.initials: SJ
authors.lastname: Martindale
authors.forename: R S
authors.initials: RS
authors.lastname: Mosca
authors.forename: E L
authors.initials: EL
authors.lastname: Bove
mesh_terms: D007611:Aprotinin / Q000008:administration & dosage / Q000191:economics / Q000627:therapeutic use*; D006348:Cardiac Surgical Procedures / Q000191:economics; D002648:Child; D002675:Child, Preschool; D017046:Cost Savings; D003362:Cost-Benefit Analysis; D004311:Double-Blind Method; D017707:Erythrocyte Transfusion / Q000009:adverse effects / Q000191:economics; D005260:Female; D006490:Hemostatics / Q000008:administration & dosage / Q000191:economics / Q000627:therapeutic use*; D017722:Hospital Charges; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007902:Length of Stay; D008297:Male; D009873:Operating Rooms / Q000191:economics; D010919:Placebos; D010949:Plasma; D017713:Platelet Transfusion / Q000009:adverse effects / Q000191:economics; D011183:Postoperative Complications; D011446:Prospective Studies; D012086:Reoperation; D012307:Risk Factors; D013997:Time Factors
chemical_list: D006490:Hemostatics; D010919:Placebos; D007611:Aprotinin