title: Bone marrow uptake of fluorine-18-fluorodeoxyglucose following treatment with hematopoietic growth factors: initial evaluation.
abstract: Hematopoietic growth factors (HGF) such as G-CSF and GM-CSF stimulate cell growth of the bone marrow and thereby mitigate the myelotoxic effect of chemotherapy. Using 18F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) for therapy response monitoring of patients with small-cell lung cancer, both an extension and an intensification of thoracic bone marrow uptake were noted in patients treated with HGF (n = 5) compared to those patients without HGF supplementation (n = 11). FDG uptake was a very sensitive marker of stimulated hematopoiesis, and both the extension and the intensification of uptake have to be noted during HGF therapy.
authors.affiliation: German Cancer Research Center (DKFZ), Department of Radiological Diagnostics and Therapy, Heidelberg, Germany. M.Knopp@dkfz-heidelberg.de
authors.forename: M V
authors.initials: MV
authors.lastname: Knopp
authors.forename: H
authors.initials: H
authors.lastname: Bischoff
authors.forename: A
authors.initials: A
authors.lastname: Rimac
authors.forename: F
authors.initials: F
authors.lastname: Oberdorfer
authors.forename: G
authors.initials: G
authors.lastname: van Kaick
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001853:Bone Marrow / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism*; D018288:Carcinoma, Small Cell / Q000188:drug therapy; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D004311:Double-Blind Method; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D016298:Hematopoietic Cell Growth Factors / Q000627:therapeutic use*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014055:Tomography, Emission-Computed
chemical_list: D000970:Antineoplastic Agents; D005462:Fluorine Radioisotopes; D016298:Hematopoietic Cell Growth Factors; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose