Hodgkin's disease: historical perspective and clinical presentation.
In conclusion, emphasis has shifted from a progressive increase in the weight of treatment to the reduction of management aggressiveness for some subsets of patients by taking advantage of clinical presentation and risk factors. The first period was based on the philosophy that extensive work-up can help to minimize treatment. The goal has become to avoid unnecessary invasive techniques. With better knowledge of the late effects and causes of death, there is now a consensus that management should be modulated according to the individual characteristics of the patient. The aim of further studies will be to progress in the identification of the various subsets of HD and to introduce new therapeutic modalities as effective but less toxic than the present ones. This approach requires for each subset of patients a rigorous assessment of the long-term cost and benefit of the various therapeutic modalities used for treatment of HD.
Tubiana
M
M
Institut Gustave-Roussy, Villejuif, France.
D049672:History, 19th Century; D049673:History, 20th Century; D006689:Hodgkin Disease / Q000175:diagnosis / Q000266:history* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007813:Laparotomy / Q000266:history; D009367:Neoplasm Staging / Q000266:history; D011379:Prognosis