title: Acromegaly presenting with diabetic ketoacidosis.
abstract: Diabetes in acromegaly is usually non-insulin dependent and is secondary to insulin resistance caused by growth hormone excess. Diabetic ketoacidosis is a result of relative insulin deficiency and is a rare feature of acromegaly. We describe a case of acromegaly presenting with diabetic ketoacidosis. We demonstrate that growth hormone excess can cause diabetic ketoacidosis in the presence of relative, but not absolute insulin deficiency.
authors.affiliation: Department of Endocrinology and Metabolic Medicine, University College London Hospitals NHS Trust, UK.
authors.forename: J R
authors.initials: JR
authors.lastname: Katz
authors.forename: R
authors.initials: R
authors.lastname: Edwards
authors.forename: M
authors.initials: M
authors.lastname: Khan
authors.forename: G S
authors.initials: GS
authors.lastname: Conway
mesh_terms: D000172:Acromegaly / Q000097:blood / Q000150:complications* / Q000601:surgery; D000236:Adenoma / Q000097:blood / Q000150:complications / Q000601:surgery; D000328:Adult; D016883:Diabetic Ketoacidosis / Q000097:blood / Q000209:etiology* / Q000601:surgery; D005951:Glucose Tolerance Test; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D010911:Pituitary Neoplasms / Q000097:blood / Q000150:complications / Q000601:surgery
chemical_list: D007328:Insulin; D013006:Growth Hormone