title: Acute liver injury and octreotide.
abstract: Octreotide is a synthetic analogue of somatostatin with therapeutic applications in a variety of endocrine and gastrointestinal disorders. We report a patient with acromegaly who developed acute hepatocellular liver injury after receiving two 0.1-mg doses of octreotide. The drug causality was confirmed by rechallenge. To our knowledge this is the second reported case in the literature.
authors.affiliation: Gastroenterology Section, Hospital Virgen de la Luz, Cuenca, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: González-Martín
authors.forename: S
authors.initials: S
authors.lastname: Donnay
authors.forename: J
authors.initials: J
authors.lastname: Morillas
authors.forename: C
authors.initials: C
authors.lastname: Gómez-Aparicio
authors.forename: J
authors.initials: J
authors.lastname: Garcia-Cano
authors.forename: G
authors.initials: G
authors.lastname: Pérez-Vigara
authors.forename: A
authors.initials: A
authors.lastname: Roldán
mesh_terms: D000172:Acromegaly / Q000188:drug therapy / Q000209:etiology; D000236:Adenoma / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015282:Octreotide / Q000009:adverse effects* / Q000627:therapeutic use; D010911:Pituitary Neoplasms / Q000150:complications / Q000188:drug therapy / Q000601:surgery
chemical_list: D018931:Antineoplastic Agents, Hormonal; D015282:Octreotide