title: [C10-aminoderivatives of colchicine: synthesis, structure and biological activity].
abstract: Replacement of the 10-methoxy group of colchicine by amino and amino acid substituents sharply decreased its toxicity and only slightly decreased its tubulin-binding activity, and thus, gave rise to a number of weakly toxic colchicine analogs. In particular, highly active 10-(N-glycino)-10-demethoxycolchicine and 10-[N-(beta-alanino)]-10-demethoxycolchicine were prepared.
authors.forename: N A
authors.initials: NA
authors.lastname: Aĭtozhina
authors.forename: E O
authors.initials: EO
authors.lastname: Esbolaev
authors.forename: T A
authors.initials: TA
authors.lastname: Zubenko
authors.forename: K A
authors.initials: KA
authors.lastname: Toĭbaeva
authors.forename: L A
authors.initials: LA
authors.lastname: Aleksandrova
mesh_terms: D000588:Amines / Q000737:chemistry; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003078:Colchicine / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D051379:Mice; D008968:Molecular Conformation; D014407:Tumor Cells, Cultured
chemical_list: D000588:Amines; D003078:Colchicine