Protective effect of fish oil against stress-induced gastric injury in rats.
The effect of fish oil and olive oil on the gastric mucosal damage induced by cold-restraint stress was investigated in rats. The oils were dietary supplemented for 3 weeks. The results demonstrate that a diet containing fish oil, when ingested for 3 weeks before exposure to stress, protected from gastric ulceration significantly (p < 0.01) and led to a statistically significant increase both in mucus and phospholipid content of the gastric mucosal barrier (p < 0.02 and p <0.001, resp.) in cold-restraint stress-induced gastric injury in rats. However, further studies are required to determine the role of dietary fish oils in the prophylaxis and treatment of peptic ulcer.
Ulak
G
G
Department of Pharmacology, Faculty of Medicine, University of Dicle, Diyarbakir, Turkey.
Ciçek
R
R
Sermet
A
A
Güzel
C
C
Ulak
M
M
Denlï
O
O
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D003080:Cold Temperature; D005260:Female; D005395:Fish Oils / Q000627:therapeutic use*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009093:Mucus / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013315:Stress, Psychological / Q000150:complications*
D000897:Anti-Ulcer Agents; D005395:Fish Oils