title: Osteolytic lesions as a presenting sign of acute nonlymphocytic leukemia.
abstract: Osteolytic lesions occur rarely in acute leukemia, especially in adults. We describe a patient with chronic myelomonocytic leukemia, in whom multiple osteolytic lesions were the presenting sign of the transformation into acute leukemia. Local irradiation to a painful lesion in the left hip resulted in transient but significant symptomatic relief with improved quality of life. We conclude that osteolytic lesions, although rare in adult acute leukemia, indicate an advanced disease state, but may respond to palliative local irradiation.
authors.affiliation: Department of Medicine B, Hasharon Hospital, Petah-Tikva, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Ben-Dayan
authors.forename: A
authors.initials: A
authors.lastname: Zeidman
authors.forename: M
authors.initials: M
authors.lastname: Djaldetti
authors.forename: M
authors.initials: M
authors.lastname: Mittelman
mesh_terms: D000368:Aged; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000473:pathology; D009190:Myelodysplastic Syndromes / Q000150:complications*; D010014:Osteolysis / Q000150:complications* / Q000532:radiotherapy*