Immune therapy with macrophages: present status and critical requirements for implementation.
Adoptive transfer of activated macrophages has been validated in animal experimental tumor models; clinical trials are ongoing (70 patients up to now). The mechanisms involved are reviewed as well as improved and standardized procedures for macrophage differentiation and activation. New developments including specific Ag presentation and gene therapy are discussed.
Bartoleyns
J
J
LFB, Les Ulis, France.
Romet-Lemonne
J L
JL
Chokri
M
M
Lopez
M
M
D000818:Animals; D002986:Clinical Trials as Topic; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods / Q000592:standards; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology* / Q000637:transplantation*