title: Adaptive computer-aided diagnosis scheme of digitized mammograms.
abstract: OBJECTIVE
  We investigated an adaptive rule-based computer-aided diagnosis (CAD) scheme for digitized mammograms that can be optimized by using an image difficulty index as determined from global measures of image characteristics.
  
  
  METHODS
  First, we defined an image "difficulty" index based on image feature measurements in both the spatial and frequency domains. The CAD scheme then segmented the database into three groups. An image database of 428 digitized mammograms with 220 verified masses was randomly divided into two subsets, one for training (rule-setting) and the other for testing the adaptive CAD scheme. Each of the image difficulty groups in the training set was optimized independently to achieve a low false-positive detection rate while maintaining high detection sensitivity. Scheme performance was then evaluated with the test set, and the results were compared with a global rule-based system that was optimized without the adaptive method.
  
  
  RESULTS
  In this preliminary study, a relatively simple adaptive scheme reduced false-positive mass detections compared with the nonadaptive scheme from 0.85 to 0.53 per image. At the same time sensitivity was not significantly changed.
  
  
  CONCLUSIONS
  This adaptive CAD scheme has distinct advantages in improving CAD scheme performance as long as the training database includes a large number of cases in each image difficulty group with a variety of true-positive abnormalities.
authors.affiliation: Department of Radiology, University of Pittsburgh, PA 15261-0001, USA.
authors.forename: B
authors.initials: B
authors.lastname: Zheng
authors.forename: Y H
authors.initials: YH
authors.lastname: Chang
authors.forename: D
authors.initials: D
authors.lastname: Gur
mesh_terms: D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008327:Mammography; D011856:Radiographic Image Enhancement; D011857:Radiographic Image Interpretation, Computer-Assisted; D012680:Sensitivity and Specificity