title: Successful treatment on an out-patient basis of a patient with Down's syndrome and disseminated testicular seminoma.
abstract: Due to a high incidence of undescended testicles, patients with Down's syndrome have an increased risk of testicular cancer. The treatment of these patients with the successful cisplatin-containing regimens, which are however toxic and require hospitalization, can cause several problems. We present a patient with Down's syndrome suffering from a disseminated seminomatous tumour of the testis who has been successfully treated with combination chemotherapy on an out-patient basis.
authors.affiliation: Department of Internal Medicine, University Hospital, Groningen, Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: Sleijfer
authors.forename: H S
authors.initials: HS
authors.lastname: Koops
authors.forename: W T
authors.initials: WT
authors.lastname: van der Graaf
mesh_terms: D000328:Adult; D000553:Ambulatory Care; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects; D003456:Cryptorchidism / Q000150:complications / Q000235:genetics; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D004314:Down Syndrome / Q000150:complications* / Q000235:genetics; D006801:Humans; D008297:Male; D012307:Risk Factors; D018239:Seminoma / Q000188:drug therapy* / Q000235:genetics; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000235:genetics; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D014750:Vincristine; D003520:Cyclophosphamide; D016190:Carboplatin