title: Motility and tone of the left colon in constipation: a role in clinical practice?
abstract: OBJECTIVE
  Colonic motor mechanisms deranged in constipation are not understood completely. Our aim was to measure left colonic motility and tone, during fasting and postprandially in patients with chronic constipation.
  
  
  METHODS
  During 1 h fasting and 2 h postprandially, we measured pressures (multilumen manometry) and tone (barostat) in the left colon of 15 healthy controls and 40 patients with chronic constipation associated with slow (n = 15) or normal colonic transit (n = 12) or outlet obstruction (n = 13).
  
  
  RESULTS
  Fasting tone was similar in all groups, and all demonstrated a significant increase in motor activity to food. There was lower postprandial tone (p < 0.05) in the slow transit and outlet obstruction groups. There were no differences in the timing of the tonic response or the number or amplitude of high-pressure propagated contractions. The slow transit group had lower postprandial phasic responses in the rectosigmoid (p < 0.05) and descending (p < 0.1) colon; the outlet obstruction group had lesser descending (p < 0.05) and rectosigmoid (p < 0.1) colon phasic motility.
  
  
  CONCLUSIONS
  Colonic intraluminal measurements alone do not discriminate subgroups of chronic constipation more accurately than transit and pelvic floor tests, and currently have a limited role in clinical practice. However, manometry and tone measurements may be helpful in confirming a diagnosis of slow transit constipation (colonic inertia) in patients considered candidates for surgical treatment.
authors.affiliation: Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: M D
authors.initials: MD
authors.lastname: O'Brien
authors.forename: M
authors.initials: M
authors.lastname: Camilleri
authors.forename: M R
authors.initials: MR
authors.lastname: von der Ohe
authors.forename: S F
authors.initials: SF
authors.lastname: Phillips
authors.forename: J H
authors.initials: JH
authors.lastname: Pemberton
authors.forename: C M
authors.initials: CM
authors.lastname: Prather
authors.forename: J A
authors.initials: JA
authors.lastname: Wiste
authors.forename: R B
authors.initials: RB
authors.lastname: Hanson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003106:Colon / Q000503:physiopathology*; D003248:Constipation / Q000503:physiopathology*; D004435:Eating; D005260:Female; D005769:Gastrointestinal Motility; D005772:Gastrointestinal Transit; D006801:Humans; D008297:Male; D008875:Middle Aged; D009129:Muscle Tonus; D009130:Muscle, Smooth / Q000503:physiopathology*; D012016:Reference Values