Studies on the constituents of Cimicifuga species. XIX. Eight new glycosides from Cimicifuga simplex Wormsk.
Eight new glycosides were isolated from Cimicifuga simplex (Ranunculaceae), and their structures were determined to be 23-O-acetyl-7-8-didehydroshengmanol-3-O-alpha-L-arabinopyranosi de (1), 24-epi-24-O-acetyl-7,-8- didehydrohydroshengmanol-3-O-beta-D-galactopyranoside (2), 7,8-didehydrocimigenol-3-O-beta-D-galacytopyranoside (3), 24-epi-24-O-acetylhydroshengmanol-3-O-beta-D-galactopyranoside (4), cimigenol-3-O-beta-D-galactopyranoside (5), 25-O-methylcimigenol-3-O-beta-D-galactopyranoside (6), 25-O-acetylcimigenol-3-O-beta-D-galactopyranoside (7) and 25-O-acetylcimigenol-3-O-beta-D-glucopyranoside (8). Genuine aglycones were obtained by the hydrolysis of 1--7 with lactase F[Amano] and of 8 with cellulase T[amano]4. Acerinol was prepared from 7,8-didehydrocimigenol and showed antilipemic effects.
Kusano
A
A
Osaka University of Pharmaceutical Sciences, Japan.
Shibano
M
M
Kusano
G
G
Miyase
T
T
D000818:Animals; D002240:Carbohydrate Sequence; D002784:Cholesterol / Q000097:blood; D002994:Clofibrate / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008969:Molecular Sequence Data; D010946:Plants, Medicinal / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain / Q000187:drug effects
D006027:Glycosides; D000960:Hypolipidemic Agents; D014280:Triglycerides; D002784:Cholesterol; D002994:Clofibrate