title: Immunoproliferative small intestinal disease: a frequently missed diagnosis.
abstract: Immunoproliferative small intestinal disease (IPSID) is a poorly recognized cause of malabsorption syndrome in India. Clinicopathological features of five patients with IPSID seen over a two-year period are described. Our data suggest that IPSID is commonly misdiagnosed as intestinal tuberculosis due to lack of awareness and reluctance to obtain small bowel biopsies. Empirical institution of anti-tubercular chemotherapy not only leads to delayed diagnosis but also possibly alters the natural history of the disease, resulting in an intermediate phase of amelioration followed by a terminal phase of lymphomatous transformation. The disease is therefore usually diagnosed at an advanced stage and hence is associated with a relatively poor outcome.
authors.affiliation: Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow.
authors.forename: A S
authors.initials: AS
authors.lastname: Puri
authors.forename: M
authors.initials: M
authors.lastname: Kumar
authors.forename: E M
authors.initials: EM
authors.lastname: Khan
authors.forename: R
authors.initials: R
authors.lastname: Pandey
authors.forename: R
authors.initials: R
authors.lastname: Aggarwal
authors.forename: S
authors.initials: S
authors.lastname: Naik
authors.forename: G
authors.initials: G
authors.lastname: Choudhuri
authors.forename: S R
authors.initials: SR
authors.lastname: Naik
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007161:Immunoproliferative Small Intestinal Disease / Q000175:diagnosis*; D007410:Intestinal Diseases / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D014385:Tuberculosis, Gastrointestinal / Q000175:diagnosis