Membrane adhesion in peripheral myelin: good and bad wraps with protein P0.
Recent molecular models and crystallographic analysis of the major protein of peripheral myelin have provided new insights into the molecular basis of membrane adhesion in myelin. These studies have proved useful in understanding the molecular basis of clinical phenotypes in certain demyelinating neuropathies.
Kirschner
D A
DA
Department of Biology, Boston College, Chestnut Hill, MA 02167, USA. dkirsch@abby.bc.edu
Inouye
H
H
Saavedra
R A
RA
D000818:Animals; D018360:Crystallography, X-Ray; D003711:Demyelinating Diseases / Q000209:etiology*; D051379:Mice; D008958:Models, Molecular; D018993:Myelin P0 Protein / Q000737:chemistry*; D009186:Myelin Sheath / Q000648:ultrastructure*; D009412:Nerve Fibers / Q000648:ultrastructure*; D011487:Protein Conformation; D011817:Rabbits
D018993:Myelin P0 Protein