title: The effect of sodium trimetaphosphate on caries: a 3-year clinical toothpaste trial.
abstract: The objective of this study was to assess the anticaries efficacy of a toothpaste containing 3% sodium trimetaphosphate (TMP; test) relative to a toothpaste containing no caries-preventive agent (control). The study was designed as a 3-year double-blind caries incidence study involving about 2,500 subjects aged 11 years at baseline. After a clinical examination, subjects were stratified by sex, presence of supragingival calculus and caries status and randomly assigned to either the control or the test group. Clinical examinations then took place at annual intervals. At baseline and at the final examination bite-wing radiographs were taken of subjects not radiographed within the previous 6 months. The change in caries between baseline and the 3-year examination was calculated as DMFS increments. The results showed a statistically significant difference of 8% between the test and control groups (p < 0.05). In subjects brushing twice daily the difference between the test and control group was 11% (p < 0.01). It is concluded that, when used regularly, a toothpaste containing 3% TMP will be effective against caries.
authors.affiliation: Conservative Department, University Dental Clinic, Graz, Austria.
authors.forename: P
authors.initials: P
authors.lastname: Städtler
authors.forename: K
authors.initials: K
authors.lastname: Müller-Bruckschwaiger
authors.forename: F
authors.initials: F
authors.lastname: Schäfer
authors.forename: E
authors.initials: E
authors.lastname: Huntington
mesh_terms: D000704:Analysis of Variance; D001317:Austria / Q000453:epidemiology; D002327:Cariostatic Agents / Q000627:therapeutic use*; D002648:Child; D004245:DMF Index; D003731:Dental Caries / Q000453:epidemiology / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D011122:Polyphosphates / Q000627:therapeutic use*; D014100:Toothpastes / Q000627:therapeutic use*; D014172:Transillumination / Q000379:methods; D016896:Treatment Outcome
chemical_list: D002327:Cariostatic Agents; D011122:Polyphosphates; D014100:Toothpastes; C009293:trimetaphosphoric acid