Chloride transport and the actions of nedocromil sodium and cromolyn sodium in asthma.
Nedocromil sodium has been shown to be capable of inhibiting chloride ion flux in mast cells, epithelial cells, and neurons. This feature may explain how it can prevent responses such as mast-cell degranulation, the effects of osmolarity changes in the airways, and neuronal activation. This mechanism may also provide a unifying hypothesis to explain the effects of nedocromil sodium on a range of cell types involved in asthma, such as sensory and efferent neurons and cells involved in inflammation.
Alton
E W
EW
Ion Transport Unit, National Heart and Lung Institute, London, United Kingdom.
Norris
A A
AA
D001249:Asthma / Q000378:metabolism* / Q000473:pathology; D001692:Biological Transport; D048429:Cell Size / Q000187:drug effects; D018118:Chloride Channels / Q000187:drug effects; D002712:Chlorides / Q000378:metabolism; D004205:Cromolyn Sodium / Q000494:pharmacology*; D006801:Humans; D017835:Nedocromil / Q000494:pharmacology*
D018118:Chloride Channels; D002712:Chlorides; D017835:Nedocromil; D004205:Cromolyn Sodium