title: Cost effectiveness of detecting Barrett's cancer.
abstract: BACKGROUND
  Screening Barrett's oesophagus is controversial owing to a large variation in the reported incidence of neoplastic change and lack of evidence that screening improves tumour prognosis.
  
  
  OBJECTIVE
  To determine the incidence of Barrett's cancer, its cost of detection, and stage of disease at time of diagnosis.
  
  
  METHODS
  Data from our surveillance programme have been reviewed to assess the incidence of malignant change, tumour stage at diagnosis, and the cost per cancer detected.
  
  
  RESULTS
  166 patients had annual endoscopic surveillance. Six patients (five men) developed cancer-an incidence of one cancer per 59 male and 167 female patient-years of follow up. The screened group had a significantly earlier stage than a control group of unscreened cancers (p < 0.05). The cost of detecting one cancer was Pounds 14 868 for men and Pounds 42 084 for women.
  
  
  CONCLUSIONS
  The cost of screening for Barrett's cancer is high but may be justified on the basis of the high incidence of detecting early stage disease.
authors.affiliation: Department of Surgery, Royal Liverpool Hospital.
authors.forename: T A
authors.initials: TA
authors.lastname: Wright
authors.forename: M R
authors.initials: MR
authors.lastname: Gray
authors.forename: A I
authors.initials: AI
authors.lastname: Morris
authors.forename: I T
authors.initials: IT
authors.lastname: Gilmore
authors.forename: A
authors.initials: A
authors.lastname: Ellis
authors.forename: H L
authors.initials: HL
authors.lastname: Smart
authors.forename: M
authors.initials: M
authors.lastname: Myskow
authors.forename: J
authors.initials: J
authors.lastname: Nash
authors.forename: R J
authors.initials: RJ
authors.lastname: Donnelly
authors.forename: A N
authors.initials: AN
authors.lastname: Kingsnorth
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001471:Barrett Esophagus / Q000473:pathology / Q000517:prevention & control*; D003362:Cost-Benefit Analysis; D004938:Esophageal Neoplasms / Q000517:prevention & control; D004945:Esophagoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008403:Mass Screening / Q000191:economics*; D008875:Middle Aged; D009367:Neoplasm Staging; D011230:Precancerous Conditions / Q000517:prevention & control