Efficient syntheses of polyamine and polyamine amide voltage-sensitive calcium channel blockers: FTX-3.3 and sFTX-3.3.
Efficient syntheses of FTX-3.3 and sFTX-3.3, voltage-sensitive calcium channel blockers are described. These modified polyamines were prepared from selectively protected polyamines and purified on a practical scale.
Moya
E
E
Department of Medicinal Chemistry, University of Bath, Claverton Down, UK.
Blagbrough
I S
IS
D002121:Calcium Channel Blockers / Q000138:chemical synthesis*; D015394:Molecular Structure; D011073:Polyamines / Q000138:chemical synthesis*
D002121:Calcium Channel Blockers; C102391:FTX 3.3; D011073:Polyamines; C102392:sFTX 3.3