Cortical hyperostosis simulating osteomyelitis after short-term prostaglandin E1 infusion.
We describe a newborn with cyanotic congenital heart disease who developed severe cortical hyperostosis of his long bones simulating osteomyelitis with remarkable elevation of alkaline phosphatase on the 11th day of prostaglandin E1 (PGE1) infusion. Soft tissue swelling and tenderness disappeared 6 days after discontinuation of PGE1, however alkaline phosphatase remained high.


CONCLUSIONS
To our knowledge this is the first reported case that presented with such an acute complication of PGE1 therapy within a short period.
Kalloghlian
A K
AK
Department of Paediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Frayha
H H
HH
deMoor
M M
MM
D000527:Alprostadil / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004374:Ductus Arteriosus, Patent / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005360:Fibula / Q000000981:diagnostic imaging; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D006958:Hyperostosis, Cortical, Congenital / Q000139:chemically induced* / Q000000981:diagnostic imaging; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008297:Male; D010019:Osteomyelitis / Q000000981:diagnostic imaging*; D011859:Radiography; D013977:Tibia / Q000000981:diagnostic imaging
D000527:Alprostadil