[Stimulation of regenerative processes and correction of the functional activity of the liver in its partial resection and toxic lesions].
The effects of hepatotropic growth factors (HGFs) and phospholipid drugs on the recovery of functions and the regeneration of the rat liver were studied in CC14-induced toxic damage and after partial hepatectomy (PHE). HGFs isolated from the cytoplasmic cells of the regenerating liver, as well as from the liver of the animals given prodigiozan and from the media taken after culturing the explants of the regenerating liver were found to stimulate DNA synthesis and hepatocytic proliferation following PHE and in the cirrhotic liver. Prodigiozan was shown to induce the formation of HGFs not only in the rat liver following PHE, but in the liver of intact animals. It was established that the covalently binding complex of albumin and bilirubin stimulated the synthesis of proteins and DNA in the regenerating liver, but non-covalently binding complex inhibited these processes. When CC14 was administered to the animals, the two complexes enhanced the reparative synthesis of DNA, without changing the level of replicating synthesis, the non-covalently binding complex completely eliminating the single-strand breaks in DNA. Phospholipid agents containing soybean and sunflower phosphatidylcholines increased the synthesis of RNA and albumin, which were decreased due to exposure to CC14 and had the property of stimulating the synthesis of total DNA and considerably enhancing that of mitochondrial DNA.
Abakumova
O Iu
OIu
Kutsenko
N G
NG
Fedorova
L M
LM
Podobed
O V
OV
Gavril'chak
A V
AV
Shekhter
A B
AB
Kovaleva
G G
GG
Popov
A A
AA
Li
V S
VS
Karagiulian
S R
SR
Mitina
V Kh
VKh
Kliashchitskiĭ
B A
BA
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000209:etiology; D004247:DNA / Q000096:biosynthesis; D006368:Helianthus; D006498:Hepatectomy; D017228:Hepatocyte Growth Factor / Q000494:pharmacology* / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D008106:Liver Cirrhosis, Experimental / Q000601:surgery; D008115:Liver Regeneration / Q000187:drug effects*; D010713:Phosphatidylcholines / Q000494:pharmacology* / Q000627:therapeutic use; D011354:Prodigiozan / Q000494:pharmacology* / Q000627:therapeutic use; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D013025:Glycine max
D000900:Anti-Bacterial Agents; D010713:Phosphatidylcholines; D012313:RNA; D017228:Hepatocyte Growth Factor; D004247:DNA; D011354:Prodigiozan; D002251:Carbon Tetrachloride