title: Performance of a computer simulated neural network trained to categorise normal, premalignant and malignant oral smears.
abstract: The accurate detection of malignant neoplasms whilst they are still small is recognised as one of the main factors increasing chances of survival. Neural networks have many biomedical applications and they have been applied to neoplasia but their use in oral pathology has only recently been documented. The objectives of this study were to train networks to discriminate between normal and dysplastic mucosa. Each network was trained by back propagation, internal cross validation and tested on additional data. The data were derived by analysing 348 intra-oral smears and included mean nuclear and mean cytoplasmic areas of the smears measured by image analysis. A neural network differentiated between normal/non-dysplastic mucosa and dysplastic/malignant mucosa (specificity 0.82, sensitivity 0.76). These early results suggest that integrating neural networks and image analysis, as well as investigating additional criteria, could enhance automation and accuracy of smear techniques in diagnosing oral malignancy.
authors.affiliation: Department of Oral Surgery, Medicine & Pathology, University of Wales College of Medicine, Heath Park, Cardiff, Wales, UK.
authors.forename: M R
authors.initials: MR
authors.lastname: Brickley
authors.forename: J G
authors.initials: JG
authors.lastname: Cowpe
authors.forename: J P
authors.initials: JP
authors.lastname: Shepherd
mesh_terms: D001331:Automation; D002467:Cell Nucleus / Q000648:ultrastructure; D003581:Cytodiagnosis; D003593:Cytoplasm / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D009061:Mouth Mucosa / Q000166:cytology*; D009062:Mouth Neoplasms / Q000473:pathology*; D016571:Neural Networks, Computer; D011230:Precancerous Conditions / Q000473:pathology*; D015203:Reproducibility of Results