Phenotypic and functional evaluation of natural killer cells in thymectomized children.
The purpose of this study was to determine the effect of thymectomy on the number and activity of NK cells in the peripheral blood of children submitted to thymus removal. Twenty-three children, aged 4 to 48 months at thymectomy, whose thymus was fully removed to permit access to the heart for corrective surgery, were studied. Only children thymectomized during the first year of life had a decreased number of CD2+/CD3+, CD4+/CD16- , and CD8+/CD16- T subsets and an increase in the CD16-/CD56bright+ NK subset. In addition, the CD57-/CD16+ and CD57-/D56+ subsets which are shared by T and NK cells were increased. These findings associated with a tendency to increased NK activity suggest that the human thymus is partially involved in the control of the release of circulating T cells and may negatively modulate some NK subsets, as well as NK activity, during the first year of life but not later.
Ramos
S B
SB
Department of Clinical Medicine, School of Medicine of Ribeirão Preto, Brazil.
Garcia
A B
AB
Viana
S R
SR
Voltarelli
J C
JC
Falcão
R P
RP
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D007694:Killer Cells, Natural / Q000145:classification* / Q000276:immunology*; D018655:Lymphocyte Count; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013934:Thymectomy