Investigation of the chemical stability of a new growth hormone-releasing hormone (GHRH) analogue by HPLC.
The stability of a new active growth hormone-releasing hormone analogue (D-Ala2,Nle27,(gamma-amino-butyric acid)30-GHRH(1-30)-NH2) was investigated during storage at different temperatures in aqueous solution. Samples stored for various periods of time were analysed by HPLC. It is concluded that in aqueous solution D-Ala2, Nle27,(gamma-amino-butyric acid)30-growth hormone-releasing hormone (1-30)-NH2 is stable: at least for 36 days at 4 degrees C; for 28 days at 25 degrees C; and for 10 days at 37 degrees C.
Idei
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I. Institute of Biochemistry, Semmelweis University, Medical School, Budapest, Hungary.
Mezö
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Szabó
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Kéri
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D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D013007:Growth Hormone-Releasing Hormone / Q000031:analogs & derivatives* / Q000737:chemistry*; D008969:Molecular Sequence Data; D012996:Solutions; D013696:Temperature
D012996:Solutions; C101706:somatotropin-releasing hormone-(1-30)-amide, Ala(2)-Nle(27)-GABA(30)-; D013007:Growth Hormone-Releasing Hormone