Granulocyte-colony stimulating factor concentrations in a patient with plasma cell dyscrasia and clinical features of chronic neutrophilic leukaemia.
In order to study the pathogenesis of plasma cell dyscrasias with associated clinical features of chronic neutrophilic leukaemia, the concentration of granulocyte-colony stimulating factor (G-CSF) was measured in a patient, a 73 year old man, who underwent steroid pulse therapy. High G-CSF concentrations and leucocyte counts prior to treatment declined rapidly on administration of dexamethazone, but rose subsequently. G-CSF was not detected in primary cultures of bone marrow cells, but large amounts of interleukin-6 were found in the culture supernatant. These observations suggest that the neutrophilia observed in the patient represented a reactive response to G-CSF secreted from abnormal plasma cells or stromal cells rather than the existence of a genuine myeloproliferative disorder.
Nagai
M
M
First Department of Internal Medicine, Kagawa Medical School, Japan.
Oda
S
S
Iwamoto
M
M
Marumoto
K
K
Fujita
M
M
Takahara
J
J
D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001853:Bone Marrow / Q000378:metabolism; D003907:Dexamethasone / Q000627:therapeutic use; D016179:Granulocyte Colony-Stimulating Factor / Q000032:analysis*; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis; D015467:Leukemia, Neutrophilic, Chronic / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D007958:Leukocyte Count; D008297:Male; D010265:Paraproteinemias / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*
D018931:Antineoplastic Agents, Hormonal; D015850:Interleukin-6; D016179:Granulocyte Colony-Stimulating Factor; D003907:Dexamethasone