[C10-aminoderivatives of colchicine: synthesis, structure and biological activity].
Replacement of the 10-methoxy group of colchicine by amino and amino acid substituents sharply decreased its toxicity and only slightly decreased its tubulin-binding activity, and thus, gave rise to a number of weakly toxic colchicine analogs. In particular, highly active 10-(N-glycino)-10-demethoxycolchicine and 10-[N-(beta-alanino)]-10-demethoxycolchicine were prepared.
Aĭtozhina
N A
NA
Esbolaev
E O
EO
Zubenko
T A
TA
Toĭbaeva
K A
KA
Aleksandrova
L A
LA
D000588:Amines / Q000737:chemistry; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003078:Colchicine / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D051379:Mice; D008968:Molecular Conformation; D014407:Tumor Cells, Cultured
D000588:Amines; D003078:Colchicine