Incongruent follicular development reduces gamete intrafallopian transfer pregnancy rate.
OBJECTIVE
To test the null hypothesis that asymmetric or incongruent follicular development does not influence GIFT pregnancy rates (PRs).


METHODS
A prospective comparative study.


METHODS
Tertiary referral center for infertility.


METHODS
Ninety-three consecutive infertile patients having GIFT.


METHODS
Controlled ovarian hyperstimulation and GIFT.


METHODS
The incongruity ratio as a parameter of the asymmetry in follicular development and the clinical PR.


RESULTS
An inverse relationship was observed between the degree of incongruity and the clinical PRs. In patients with an incongruity ratio < 1.5, the clinical PR was 56.1%. In patients with an incongruity ratio > or = 1.5, the clinical PR was only 17.3%.


CONCLUSIONS
Incongruent follicular development during controlled ovarian hyperstimulation has a marked negative influence on the outcome of GIFT cycles. Factors such as side of the gamete transfer and oocyte quality did not account for the observed differences.
Rombauts
L
L
Monash IVF, Epworth Hospital, Richmond, Victoria, Australia.
Webster
D
D
Wood
C E
CE
Healy
D L
DL
D000328:Adult; D005260:Female; D015181:Gamete Intrafallopian Transfer; D006801:Humans; D006080:Ovarian Follicle / Q000000981:diagnostic imaging / Q000502:physiology*; D010053:Ovary / Q000503:physiopathology; D018873:Pregnancy Rate; D011446:Prospective Studies; D013268:Stimulation, Chemical; D014463:Ultrasonography