Selective modulation of non-protein sulfhydryl levels in Ehrlich ascites tumor bearing mice.
Thiazolidine derivatives (TD), prodrugs of L-cysteine (cys), synthesized by the condensation of cys with formaldehyde (thiazolidine-4-carboxylic acid-CF), acetaldehyde (2-methyl-thiazolidine-4-carboxylic acid-CA) and pyruvate (2-methylthiazolidine-2,4-dicarboxylic acid-CP), as well as amino acids thiocystine (T-cys) and cys, but not methionine (met) and S2O3(-2), successfully elevated non-protein sulfhydryl (NPSH) levels in livers of Ehrlich ascites tumor cells (EATC) bearing mice. At the same time, CA, promote a significant drop of NPSH concentration in EATC, whereas the other sulfur compounds (S-comp) have no effects. Thus TD and T-cys through their selective influence upon the level of NPSH in the liver and in cancer cells, seem to be the most interesting compounds for further studies on anticancer therapy.
Włodek
L B
LB
Institute of Medical Biochemistry, Collegium Medicum, Jagiellonian University, Kraków, Poland.
Wróbel
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D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D003545:Cysteine / Q000031:analogs & derivatives / Q000494:pharmacology; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008715:Methionine / Q000494:pharmacology; D051379:Mice; D009368:Neoplasm Transplantation; D011355:Prodrugs / Q000138:chemical synthesis / Q000494:pharmacology*; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D013885:Thiosulfates / Q000494:pharmacology
D000596:Amino Acids; D011355:Prodrugs; D013844:Thiazoles; D013885:Thiosulfates; C060197:thiocysteine; D008715:Methionine; D005978:Glutathione; D003545:Cysteine