Effects of diet and ethanol treatment on azoxymethane-induced liver and gastrointestinal neoplasia of male rats.
Epidemiological and animal studies have shown that diet and excessive alcohol consumption are major risk factors for liver and gastrointestinal cancers. This study investigated the effects of diet and alcohol consumption on azoxymethane (AOM)-induced liver and gastrointestinal neoplasia in male rats. Rats were infused intragastrically with control or ethanol-containing diets. After 35 days of dietary acclimatization, all rats received two intragastric infusions of AOM (15 mg/kg) separated by 1 week and then were maintained on standard rat food for 26 weeks. Results suggest that liver and duodenum are the major target organs when AOM is given orally and ethanol pre-exposure potentiates the AOM-induced hepatic and duodenal dysplasia.
Hakkak
R
R
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, USA.
Korourian
S
S
Ronis
M J
MJ
Badger
T M
TM
D000428:Alcohol Drinking / Q000009:adverse effects*; D000818:Animals; D001397:Azoxymethane / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D003043:Cocarcinogenesis; D003110:Colonic Neoplasms / Q000209:etiology; D004032:Diet / Q000009:adverse effects*; D004379:Duodenal Neoplasms / Q000209:etiology; D005770:Gastrointestinal Neoplasms / Q000139:chemically induced / Q000209:etiology*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000209:etiology*; D008297:Male; D010289:Parenteral Nutrition, Total; D051381:Rats; D017207:Rats, Sprague-Dawley
D002273:Carcinogens; D001397:Azoxymethane