Biological chemistry of thiols in the vasculature and in vascular-related disease.
For all their similarities in structure and common chemistry, the functions of the amino thiols in vascular biology are remarkably different. This review details the basic chemistry of sulfhydryls that dictates their functions in health and disease. In addition, the biochemistry and metabolism of each thiol are outlined, in an effort to highlight its specific contributions to the normal biology and physiology of blood vessels and to the pathogenesis of vascular-related disease.
Stamler
J S
JS
Department of Medicine, Duke Medical Center, Durham, NC, USA.
Slivka
A
A
D000818:Animals; D001808:Blood Vessels / Q000502:physiology; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism / Q000502:physiology; D003545:Cysteine / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D005978:Glutathione / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D006710:Homocysteine / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D006801:Humans; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*
D013438:Sulfhydryl Compounds; D006710:Homocysteine; D002784:Cholesterol; D005978:Glutathione; D003545:Cysteine