title: Central venous catheter infections in AIDS patients receiving daily home therapy for cytomegalovirus disease.
abstract: We studied the infection rate of long-term intravenous access used for daily home treatment of cytomegalovirus (CMV) disease in 61 AIDS patients who had 75 central venous catheters implanted for antiviral maintenance therapy between February 1989 and December 1994. In 39 patients (64%) the risk factor for AIDS was intravenous drug abuse. Sixty-three catheters were Hickman type and 12 were totally implanted ports. The cumulative follow-up time was 19000 catheter-days (52 patient-years), with median duration of placement of 249 days. The infection rate was 0.22 infections per 100 catheter days. The probability of remaining free of catheter-related sepsis was 58% at 6 months. In 25 cases (61%) antimicrobial therapy without catheter removal was successful. Three patients died because of a catheter-related infection (mortality rate 7.3%). Infection-free survival time was not related to the risk factor for AIDS (p = 0.44) or type of device (p = 0.41). The total infection rate in these patients receiving daily home maintenance therapy for CMV disease through a long-term catheter was similar to that in other AIDS patients receiving weekly treatment in hospital facilities.
authors.affiliation: Department of Microbiology, Hospital Ramón y Cajal, Madrid, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Casado
authors.forename: E
authors.initials: E
authors.lastname: Navas
authors.forename: A
authors.initials: A
authors.lastname: Garcia
authors.forename: A
authors.initials: A
authors.lastname: Antela
authors.forename: E
authors.initials: E
authors.lastname: Redondo
authors.forename: J
authors.initials: J
authors.lastname: Fortun
authors.forename: A
authors.initials: A
authors.lastname: Guerrero
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage*; D002405:Catheterization, Central Venous; D002408:Catheters, Indwelling; D003586:Cytomegalovirus Infections / Q000188:drug therapy*; D004866:Equipment Contamination; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000150:complications; D016908:Gram-Positive Bacterial Infections / Q000150:complications; D006701:Home Nursing; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013997:Time Factors
chemical_list: D000998:Antiviral Agents