Cytotoxic and antioxidative sesquiterpenoids from Heterotheca inuloides.
Four sesquiterpenoids, beta-caryophyllene, beta-caryophyllene 4,5 alpha-oxide, 7-hydroxy-3,4-dihydrocadalin, and 7-hydroxycadalin, isolated from the dried flower of Heterotheca inuloides Cass. (Asteraceae), have been found to exhibit cytotoxic activity against several solid tumor cell lines. Among them, 7-hydroxy-3,4-dihydrocadalin and 7-hydroxycadalin have also been found to inhibit autoxidative and microsomal lipid peroxidation.
Kubo
I
I
Department of Environmental Science, Policy and Management, University of California, Berkeley 94720-3112, USA.
Chaudhuri
S K
SK
Kubo
Y
Y
Sanchez
Y
Y
Ogura
T
T
Saito
T
T
Ishikawa
H
H
Haraguchi
H
H
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D001943:Breast Neoplasms; D002460:Cell Line; D005260:Female; D006367:HeLa Cells; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008545:Melanoma; D008546:Melanoma, Experimental; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D012717:Sesquiterpenes