Human thioredoxin reductase gene localization to chromosomal position 12q23-q24.1 and mRNA distribution in human tissue.
Thioredoxin reductase is a member of the pyridine nucleotide-disulfide oxidoreductase family of enzymes. By delivering reducing equivalents to thioredoxin, thioredoxin reductase exerts control over a number of redox-sensitive factors in the cell, including ribonucleotide reductase and several transcription factors. We have localized the human thioredoxin gene to chromosomal position 12q23-q24.1 by in situ hybridization. We have also determined the relative tissue distribution of thioredoxin reductase mRNA as well as thioredoxin mRNA by probing a Northern blot of several human normal tissues.
Gasdaska
J R
JR
Arizona Cancer Center, University of Arizona, Tucson 85724-5024, USA.
Gasdaska
P Y
PY
Gallegos
A
A
Powis
G
G
D002871:Chromosome Banding; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D003001:Cloning, Molecular; D018076:DNA, Complementary; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D012333:RNA, Messenger / Q000378:metabolism; D013880:Thioredoxin-Disulfide Reductase / Q000235:genetics*; D014018:Tissue Distribution
D018076:DNA, Complementary; D012333:RNA, Messenger; D013880:Thioredoxin-Disulfide Reductase