title: [Evaluation of regional cerebral blood flow in hippocampus by 99mTc-ECD SPECT: comparison with 123I-IMP SPECT].
abstract: We evaluated regional cerebral blood flow in the hippocampus in 21 patients with neurological disorders by 99mTc-ethyl cysteinate dimer (ECD) SPECT and compared the findings with those by 123I-N-isopropyl-p-iodoamphetamine (IMP) SPECT. In all subjects, SPECT was taken using ECD (740 MBq) and IMP (167 MBq) using high performance SPECT (3-head SPECT, Toshiba GCA-9300A/HG) within 3 weeks interval. Regional uptake in the hippocampus was examined in the coronal sections and images parallel to the longitudinal axis of hippocampus. ECD and IMP showed similar hippocampal uptake in 9 cases, but ECD showed less uptake than IMP in 12 cases (57%). Regional counts in the hippocampus were related to the counts in the lateral temporal cortices and the mean count ratio was lower in ECD by 8.8% than that in IMP (0.73 +/- 0.11 vs. 0.80 +/- 0.11, p < 0.001). In 6 patients suspected to have hippocampal lesion (4 cases of memory disturbance and 2 cases of epilepsy), all cases showed decreased uptake of ECD in hippocampus, but only 3 cases showed decreased uptake of IMP. This is suggestive to be relevant to the difference in the retention mechanism of ECD and IMP, but further investigation should be performed.
authors.affiliation: Department of Radiology, Mie University School of Medicine.
authors.forename: K
authors.initials: K
authors.lastname: Matsumura
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: S
authors.initials: S
authors.lastname: Aoki
authors.forename: H
authors.initials: H
authors.lastname: Nakashima
authors.forename: H
authors.initials: H
authors.lastname: Maeda
authors.forename: T
authors.initials: T
authors.lastname: Hirano
authors.forename: K
authors.initials: K
authors.lastname: Takeda
authors.forename: T
authors.initials: T
authors.lastname: Nakagawa
mesh_terms: D000368:Aged; D000662:Amphetamines; D001921:Brain / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D006624:Hippocampus / Q000098:blood supply*; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008297:Male; D015609:Organotechnetium Compounds; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D015609:Organotechnetium Compounds; D020367:Iofetamine