title: [Renal hypouricemia in juvenile diabetes mellitus].
abstract: OBJECTIVE
  To evaluate renal tubular function in young insulin dependent diabetics.
  
  
  METHODS
  Plasma uric acid levels, renal urate excretion, uric acid tubular load and uric acid fractional excretion were compared between a group of young diabetics without microalbuminuria (n = 27), between 5.5 and 16.8 years of age, and a control group (n = 22).
  
  
  RESULTS
  The plasma uric acid levels was lower in the diabetic group than in the control group (2.9 +/- 0.7 vs 3.6 +/- 0.6 mg/dl). The renal excretion of urate was higher in the diabetic group than in the control group (17.6 +/- 4.8 vs 13.6 +/- 5.1 mg/kg/d). The uric acid tubular load was similar in both groups (2.5 +/- 1.0 vs 2.4 +/- 0.7 mg/min/1.73 m2). The uric acid fractional excretion was higher in the diabetic group than in the control group (20.9 +/- 11.9 vs 11.4 +/- 4.8%). No correlation between plasma uric acid level and renal urate excretion with insulin therapy (U/kg/d), metabolic control or the time of evolution was found.
  
  
  CONCLUSIONS
  These results suggest that, in young diabetics, there is a renal hypouricemia due to tubular defects.
authors.affiliation: Servicio de Pediatría, Hospital Universitario de San Juan, Facultad de Medicina, Universidad de Alicante, San Juan de Alicante.
authors.forename: T
authors.initials: T
authors.lastname: Durá Travé
authors.forename: M
authors.initials: M
authors.lastname: Moya Benavent
authors.forename: J
authors.initials: J
authors.lastname: Casero Ariza
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000503:physiopathology / Q000652:urine; D003928:Diabetic Nephropathies / Q000097:blood* / Q000503:physiopathology / Q000652:urine; D005919:Glomerular Filtration Rate; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D014527:Uric Acid / Q000097:blood* / Q000652:urine
chemical_list: D001786:Blood Glucose; D003404:Creatinine; D006442:Glycated Hemoglobin; D014527:Uric Acid