title: Mapping of a putative tumor suppressor locus to proximal 7p in Wilms tumors.
abstract: Different findings suggest that alterations of chromosome 7 genes play a role in the development of Wilms tumors. To define the positions of these genes, we have accomplished a combined cytogenetic and molecular study on 11 sporadic Wilms tumors. In one case, where both chromosomes 7 were rearranged, the karyotypic picture was consistent with the presence of a tumor suppressor gene at 7p15. To test this hypothesis, a loss of heterozygosity analysis was performed using microsatellite markers. This revealed a common region of allele losses mapped to the proximal short arm of chromosome 7 and defined the position of the gene(s) involved in Wilms tumors within an interval of approximately 25 cM.
authors.affiliation: Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Miozzo
authors.forename: D
authors.initials: D
authors.lastname: Perotti
authors.forename: F
authors.initials: F
authors.lastname: Minoletti
authors.forename: P
authors.initials: P
authors.lastname: Mondini
authors.forename: S
authors.initials: S
authors.lastname: Pilotti
authors.forename: R
authors.initials: R
authors.lastname: Luksch
authors.forename: F
authors.initials: F
authors.lastname: Fossati-Bellani
authors.forename: M A
authors.initials: MA
authors.lastname: Pierotti
authors.forename: G
authors.initials: G
authors.lastname: Sozzi
authors.forename: P
authors.initials: P
authors.lastname: Radice
mesh_terms: D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D016147:Genes, Tumor Suppressor; D006579:Heterozygote; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics*; D008297:Male; D018895:Microsatellite Repeats; D009396:Wilms Tumor / Q000235:genetics*