title: Remission of recurrent mixed germ cell tumor of the ovary after treatment with vincristine, carboplatin, fluorouracil, and ifosfamide: a case report and review of the literature.
abstract: Mixed germ cell tumors represent about 8% of all malignant germ cell tumors of the ovary. Although there is much information in the literature on primary therapy for malignant ovarian germ cell tumors, little has been reported on salvage therapy for such tumors when they are recurrent. Based on reports of studies in testicular cancer, the preferred salvage therapy is a combination of etoposide, vinblastine, ifosfamide, and cisplatin. We describe here the case of a patient who received the combination of vincristine, carboplatin, fluorouracil, and ifosfamide as salvage therapy for recurrent malignant mixed germ cell tumor, to our knowledge this is the first report of such case treated with this combination. She has been in remission for 6 years.
authors.affiliation: University of Texas, MD Anderson Cancer Center, Houston, USA.
authors.forename: O
authors.initials: O
authors.lastname: Balat
authors.forename: A P
authors.initials: AP
authors.lastname: Kudelka
authors.forename: C L
authors.initials: CL
authors.lastname: Edwards
authors.forename: C
authors.initials: C
authors.lastname: Verschraegen
authors.forename: J J
authors.initials: JJ
authors.lastname: Kavanagh
mesh_terms: D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D018237:Germinoma / Q000188:drug therapy* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000628:therapy; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000628:therapy; D016879:Salvage Therapy; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine; D016190:Carboplatin; D005472:Fluorouracil; D007069:Ifosfamide