Scleroderma-polymyositis overlap syndrome associated with anti-Ku antibody and rimmed vacuole formation.
Scleroderma-polymyositis overlap syndrome is strongly associated with certain autoantibodies, such as anti-PM-Scl antibody and anti-Ku antibody. We describe a case of scleroderma-polymyositis overlap syndrome associated with anti-Ku antibody, which revealed rimmed vacuole formation in addition to intranuclear and intracytoplasmic filamentous inclusions in muscle biopsy specimens.
Yamanishi
Y
Y
Second Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Maeda
H
H
Katayama
S
S
Ishioka
S
S
Yamakido
M
M
D000328:Adult; D034961:Antigens, Nuclear; D001323:Autoantibodies / Q000276:immunology*; D001706:Biopsy; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D004265:DNA Helicases; D004268:DNA-Binding Proteins / Q000276:immunology*; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D000072200:Ku Autoantigen; D008854:Microscopy, Electron; D018482:Muscle, Skeletal / Q000648:ultrastructure*; D009687:Nuclear Proteins / Q000276:immunology*; D017285:Polymyositis / Q000150:complications / Q000209:etiology*; D012595:Scleroderma, Systemic / Q000150:complications / Q000209:etiology*; D013577:Syndrome; D014617:Vacuoles / Q000648:ultrastructure*
D034961:Antigens, Nuclear; D001323:Autoantibodies; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D004265:DNA Helicases; C106893:XRCC5 protein, human; C000606509:Xrcc6 protein, human; D000072200:Ku Autoantigen