Leptin: the weight-reducing plasma protein encoded by the obese gene.
Leptin, the protein encoded by the recently cloned obese gene, has the properties of a hormone released by adipose tissue, regulating appetite and energy expenditure. Injected leptin reduces body weight and food intake in mice, and in obese, diabetic mice (with a mutated obese gene), it also reduces plasma insulin and glucose. Leptin release is stimulated by insulin; leptin appears to act on the hypothalamus by inhibiting the release of the neuropeptide Y.
Wolf
G
G
Department of Nutritional Sciences, University of California at Berkeley 94720, USA.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001066:Appetite / Q000502:physiology; D001786:Blood Glucose / Q000032:analysis; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D007328:Insulin / Q000097:blood; D020738:Leptin; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009478:Neuropeptide Y / Q000378:metabolism / Q000502:physiology; D009765:Obesity / Q000235:genetics* / Q000503:physiopathology*; D011506:Proteins / Q000032:analysis / Q000235:genetics* / Q000502:physiology*; D015431:Weight Loss / Q000235:genetics / Q000502:physiology*
D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D009478:Neuropeptide Y; D011506:Proteins