title: Assessment and follow-up of alcohol-dependent liver transplantation patients. A clinical cohort.
abstract: We describe pretransplantation characteristics of 103 consecutive alcoholic cirrhotics who underwent orthotopic liver transplantation over a 28-month period, and follow-up characteristics for 58 of 82 survivors. We examined whether certain pretransplantation psychiatric and demographic variables predicted posttransplantation outcomes. Patients who were sober < or = 6 months and those who died after transplantation had longer transplant hospital stays, suggesting that physiological compromise may predict posttransplant course. Using survival analyses because of variable follow-up intervals, only age over 50 years and index hospital stays greater than 1 month showed statistical trends toward predicting shorter posttransplant survival duration. Neither pretransplant sobriety, gender, nor duration of pretransplant heavy drinking predicted posttransplant survival duration. No variable, including preoperative sobriety < or = 6 months or attendance at alcohol rehabilitation peritransplant, predicted relapse except for female gender and pretransplant unemployment, in which cases the relapse rate was doubled. Our relapse rate of 21% is comparable to recidivism rates reported from other centers and for the general alcoholic population. These findings, several of which are contrary to general beliefs, continue to challenge our presumed predictive variables in selecting the best candidates for liver transplantation.
authors.affiliation: Milton S. Hershey Medical Center, University of Pittsburgh School of Medicine, PA, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Tringali
authors.forename: P T
authors.initials: PT
authors.lastname: Trzepacz
authors.forename: A
authors.initials: A
authors.lastname: DiMartini
authors.forename: M A
authors.initials: MA
authors.lastname: Dew
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000523:psychology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007902:Length of Stay; D016031:Liver Transplantation / Q000401:mortality; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D011237:Predictive Value of Tests; D011570:Psychiatry; D012008:Recurrence; D012017:Referral and Consultation; D012307:Risk Factors; D016019:Survival Analysis