Sex-specific assembly of a dosage compensation complex on the nematode X chromosome.
In nematodes, flies, and mammals, dosage compensation equalizes X-chromosome gene expression between the sexes through chromosome-wide regulatory mechanisms that function in one sex to adjust the levels of X-linked transcripts. Here, a dosage compensation complex was identified in the nematode Caenorhabditis elegans that reduces transcript levels from the two X chromosomes in hermaphrodites. This complex contains at least four proteins, including products of the dosage compensation genes dpy-26 and dpy-27. Specific localization of the complex to the hermaphrodite X chromosomes is conferred by XX-specific regulatory genes that coordinately control both sex determination and dosage compensation.
Chuang
P T
PT
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Lieb
J D
JD
Meyer
B J
BJ
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D012734:Disorders of Sex Development; D004303:Dosage Compensation, Genetic; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D017238:Genes, Helminth; D005809:Genes, Regulator; D015801:Helminth Proteins / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D008297:Male; D009687:Nuclear Proteins / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D011233:Precipitin Tests; D018510:RNA, Helminth / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D012732:Sex Determination Analysis; D014960:X Chromosome / Q000737:chemistry / Q000378:metabolism*
D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; C090454:DPY-27 protein, C elegans; D015801:Helminth Proteins; D009687:Nuclear Proteins; D018510:RNA, Helminth; D012333:RNA, Messenger