Nonpigmenting fixed drug eruption: a new case due to betahistine.
We describe a new case of a seldom reported subset of fixed drug eruption, the nonpigmenting type. Aside from their fixed nature and their well-demarcated margins, pigmenting and non-pigmenting subsets of fixed drug eruption exhibit well-separated clinical and histological features allowing easy recognition. The precise physiopathology is currently unknown in both conditions, but a delayed hypersensitivity mechanism is likely. The nature of the inducing drugs of the nonpigmenting eruption is discussed.
Dereure
O
O
Department of Dermatology-Phlebology, CHRU Montpellier, France.
Guilhou
J J
JJ
D001621:Betahistine / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D004890:Erythema / Q000139:chemically induced / Q000473:pathology; D005260:Female; D017442:Histamine Agonists / Q000009:adverse effects*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000503:physiopathology; D008875:Middle Aged; D014581:Urticaria / Q000139:chemically induced / Q000473:pathology; D014717:Vertigo / Q000188:drug therapy
D017442:Histamine Agonists; D001621:Betahistine