DPY-26, a link between dosage compensation and meiotic chromosome segregation in the nematode.
The DPY-26 protein is required in the nematode Caenorhabditis elegans for X-chromosome dosage compensation as well as for proper meiotic chromosome segregation. DPY-26 was shown to mediate both processes through its association with chromosomes. In somatic cells, DPY-26 associates specifically with hermaphrodite X chromosomes to reduce their transcript levels. In germ cells, DPY-26 associates with all meiotic chromosomes to mediate its role in chromosome segregation. The X-specific localization of DPY-26 requires two dosage compensation proteins (DPY-27 and DPY-30) and two proteins that coordinately control both sex determination and dosage compensation (SDC-2 and SDC-3).
Lieb
J D
JD
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Capowski
E E
EE
Meneely
P
P
Meyer
B J
BJ
D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology / Q000235:genetics / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins / Q000502:physiology; D002467:Cell Nucleus / Q000737:chemistry; D002875:Chromosomes / Q000502:physiology*; D012734:Disorders of Sex Development; D004303:Dosage Compensation, Genetic; D047108:Embryonic Development; D005260:Female; D015870:Gene Expression; D017238:Genes, Helminth; D005854:Germ Cells / Q000502:physiology; D015801:Helminth Proteins / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D008297:Male; D008540:Meiosis; D008969:Molecular Sequence Data; D009154:Mutation; D009687:Nuclear Proteins / Q000502:physiology; D014960:X Chromosome / Q000502:physiology
D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; C090454:DPY-27 protein, C elegans; D015801:Helminth Proteins; D009687:Nuclear Proteins