GMP reverses the facilitatory effect of glutamate on inhibitory avoidance task in rats.
Previous studies have demonstrated that post-training intrahippocampal glutamate administration improves inhibitory avoidance task performance in rats. Antagonism of the agonist actions of glutamate by guanine nucleotides has been shown at the molecular and behavioural level. In the present investigation we demonstrate that intrahippocampal co-administration of GMP (guanosine 5'-monophosphate) reverses the facilitatory effect of glutamate on the inhibitory avoidance learning paradigm and inhibits [3H]glutamate binding in hippocampal synaptic plasma membranes. These results suggest that guanine nucleotides may modulate glutamate actions.
Rubin
M A
MA
Departamento de Quimica, Universidade Federal de Santa Maria, Brasil.
Jurach
A
A
da Costa Júnior
E M
EM
Lima
T T
TT
Jiménez-Bernal
R E
RE
Begnini
J
J
Souza
D O
DO
de Mello
C F
CF
D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D018698:Glutamic Acid / Q000378:metabolism / Q000494:pharmacology*; D006157:Guanosine Monophosphate / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013570:Synaptic Membranes / Q000187:drug effects / Q000378:metabolism
D018698:Glutamic Acid; D006157:Guanosine Monophosphate