Further evidence for an association between schizophrenia and the HLA DQB1 gene locus.
A case-control study was conducted in Singapore, in order to examine a proposed association between schizophrenia and the HLA DQB1 gene locus. The probands were male inpatients of Chinese ethnicity with schizophrenia (ICD-10 criteria, n = 102) and the controls were adults matched for gender and ethnicity (n = 111). Polymorphisms of the HLA DQB1 gene were examined using molecular typing by reverse dot-blotting (MTRB), a novel PCR based method. Among the patients, a positive association with HLA DQB1*0303 (odds ratio 4.46, C.I. 1.63, 12.17), as well as a negative association with HLA DQB1*0602 (odds ratio 0.22, C.I. 0.18, 0.83) was detected.
Nimgaonkar
V L
VL
Department of Psychiatry, University of Pittsburgh, PA 15213, USA.
Rudert
W A
WA
Zhang
X R
XR
Tsoi
W F
WF
Trucco
M
M
Saha
N
N
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D002874:Chromosome Mapping; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics; D012559:Schizophrenia / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D012565:Schizophrenic Psychology; D012846:Singapore
D005819:Genetic Markers; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen