title: Distortion of Mendelian recovery ratio for a mouse HSR is caused by maternal and zygotic effects.
abstract: An HSR in chromosome 1 which is found in many feral populations of Mus musculus domesticus was shown in previous studies to consist of a high-copy long-range repeat cluster. One such cluster, MUT, showed distorted transmission ratios when introduced by female parents. MUT/+ offspring were preferentially recovered at the expense of +/+ embryos in the progeny of male MUT/+ x female +/+ but were found at the expected 1:1 ratio in reciprocal crosses. Preferential recovery of maternal MUT was due to lethality of postimplantation +/+ embryos. There was no distortion of the recovery ratio in MUT/+ x MUT/MUT progeny: maternal MUT and + clusters were present among live implants at a 1:1 ratio. Maternal and zygotic effects therefore contribute to the phenomenon. The mechanism of their interaction is unknown.
authors.affiliation: Institut für Biologie, Medizinische Universität zu Lübeck, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Weichenhan
authors.forename: W
authors.initials: W
authors.lastname: Traut
authors.forename: B
authors.initials: B
authors.lastname: Kunze
authors.forename: H
authors.initials: H
authors.lastname: Winking
mesh_terms: D000818:Animals; D047108:Embryonic Development; D005314:Embryonic and Fetal Development; D005260:Female; D018392:Genomic Imprinting; D006579:Heterozygote; D006720:Homozygote; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D011247:Pregnancy; D015053:Zygote