title: Cell cycle control of replication initiation in eukaryotes.
abstract: Studies on the initiation of DNA replication in eukaryotes have progressed recently through different approaches that promise to converge. Proteins interacting with the origin recognition complex form a prereplicative complex early in the cell cycle. The regulation of the binding of MCM/P1 proteins to chromatin plays a key role in the replication licensing system which prevents re-replication in a single cell cycle. Cyclin-dependent kinases provide an overall control of the cell cycle by stimulating S-phase entry and possibly by preventing re-establishment of prereplicative complexes in G2 phase.
authors.affiliation: Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Hertfordshire, EN6 3LD, UK. chevalie@icrf.icnet.uk
authors.forename: S
authors.initials: S
authors.lastname: Chevalier
authors.forename: J J
authors.initials: JJ
authors.lastname: Blow
mesh_terms: D002453:Cell Cycle / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D005057:Eukaryotic Cells / Q000166:cytology*