title: Antidepressant-treated patients in ambulatory care. Mortality during a nine-year period after first treatment.
abstract: BACKGROUND
  Non-institutionalised patients treated with antidepressants have been shown to have indicators of a generalised vulnerability, such as high rates of health service use and excessive prescription drug use. Therefore, mortality in this patient group is of interest.
  
  
  METHODS
  All first-incidence antidepressant users in a defined population during a five-year period were identified. Their total mortality during a nine-year follow-up was analysed. Cox proportional hazards regression was used to analyse total mortality, and mortality in cardiovascular disease, controlling for baseline chronic medical disease.
  
  
  RESULTS
  Antidepressant treatment at the index date was a statistically significant predictor for increased long-term mortality in the over-65s, even when controlling for pre-existing chronic medical disease. Baseline ischaemic heart disease and concurrent antidepressant treatment significantly predicted mortality from cardiovascular causes.
  
  
  CONCLUSIONS
  Prescribed antidepressant treatment identifies patients who are at risk of increased mortality. For the physician in ambulatory care, knowledge of a patient's antidepressant treatment history may be a valuable tool in managing patient care.
authors.affiliation: Department of Pharmacy, University Hospital, Uppsala University, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Bingefors
authors.forename: D
authors.initials: D
authors.lastname: Isacson
authors.forename: L V
authors.initials: LV
authors.lastname: Knorring
authors.forename: B
authors.initials: B
authors.lastname: Smedby
authors.forename: K
authors.initials: K
authors.lastname: Wicknertz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000553:Ambulatory Care / Q000706:statistics & numerical data; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000401:mortality; D002423:Cause of Death; D003866:Depressive Disorder / Q000188:drug therapy* / Q000401:mortality / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010348:Patient Care Team; D016016:Proportional Hazards Models; D012306:Risk; D015996:Survival Rate; D013548:Sweden / Q000453:epidemiology
chemical_list: D000928:Antidepressive Agents