title: EON: a component-based approach to automation of protocol-directed therapy.
abstract: Provision of automated support for planning protocol-directed therapy requires a computer program to take as input clinical data stored in an electronic patient-record system and to generate as output recommendations for therapeutic interventions and laboratory testing that are defined by applicable protocols. This paper presents a synthesis of research carried out at Stanford University to model the therapy-planning task and to demonstrate a component-based architecture for building protocol-based decision-support systems. We have constructed general-purpose software components that (1) interpret abstract protocol specifications to construct appropriate patient-specific treatment plans; (2) infer from time-stamped patient data higher-level, interval-based, abstract concepts; (3) perform time-oriented queries on a time-oriented patient database; and (4) allow acquisition and maintenance of protocol knowledge in a manner that facilitates efficient processing both by humans and by computers. We have implemented these components in a computer system known as EON. Each of the components has been developed, evaluated, and reported independently. We have evaluated the integration of the components as a composite architecture by implementing T-HELPER, a computer-based patient-record system that uses EON to offer advice regarding the management of patients who are following clinical trial protocols for AIDS or HIV infection. A test of the reuse of the software components in a different clinical domain demonstrated rapid development of a prototype application to support protocol-based care of patients who have breast cancer.
authors.affiliation: Section on Medical Informatics, Stanford University School of Medicine, CA 94305-5479, USA. musen@Stanford.EDU
authors.forename: M A
authors.initials: MA
authors.lastname: Musen
authors.forename: S W
authors.initials: SW
authors.lastname: Tu
authors.forename: A K
authors.initials: AK
authors.lastname: Das
authors.forename: Y
authors.initials: Y
authors.lastname: Shahar
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D001943:Breast Neoplasms / Q000628:therapy; D019090:Case Management; D002985:Clinical Protocols; D003195:Computer Communication Networks; D005260:Female; D015658:HIV Infections / Q000628:therapy; D006801:Humans; D008962:Models, Theoretical; D011340:Problem Solving; D012985:Software Design; D018511:Systems Integration; D013813:Therapy, Computer-Assisted; D013997:Time Factors; D014584:User-Computer Interface