Threading your way to protein function.
It is still very difficult to determine the function of a protein from its sequence. One potential solution to the problem combines the concept of enzyme superfamilies with modern methods of protein structure prediction. Active-site templates can be used as search tools to identify new members of the superfamilies.
Firestine
S M
SM
The Pennsylvania State University, Department of Chemistry, 152 Davey Laboratory, University Park, PA 16802, USA.
Nixon
A E
AE
Benkovic
S J
SJ
D000595:Amino Acid Sequence; D001665:Binding Sites; D004798:Enzymes / Q000737:chemistry / Q000502:physiology; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry / Q000502:physiology*; D013329:Structure-Activity Relationship
D004798:Enzymes; D011506:Proteins