Polarographic behavior of kojic acid and its derivatives, determination of potential carcinogenicity and correlation of these properties with their other attributes.
Polarographic properties of kojic acid [5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one] and 10 of their synthetic derivatives were investigated. It was shown that these compounds are reduced in anhydrous conditions, usually in one two-electron step or in two one-electron steps. The presence of some substituents may change the course of reduction process. The polarography of these compounds in the presence of alpha-lipoic acid showed the kojic acid analog-alpha-lipoic acid complex formation. The determined potential carcinogenic activity of these compounds expressed as a parameter tg alpha is not substantial.
Vachálková
A
A
Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovakia.
Bransová
J
J
Brtko
J
J
Uher
M
M
Novotný
L
L
D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000737:chemistry* / Q000633:toxicity*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004126:Dimethylformamide / Q000737:chemistry; D004566:Electrodes; D008628:Mercury / Q000737:chemistry; D009183:Mycotoxins / Q000737:chemistry* / Q000633:toxicity*; D010084:Oxidation-Reduction; D011048:Polarography; D011753:Pyrones / Q000737:chemistry* / Q000633:toxicity*; D013329:Structure-Activity Relationship; D008063:Thioctic Acid / Q000737:chemistry
D002273:Carcinogens; D009183:Mycotoxins; D011753:Pyrones; C011890:kojic acid; D008063:Thioctic Acid; D004126:Dimethylformamide; D008628:Mercury