title: Triorganosilicon (IV) compounds: synthesis, structural study, and biological activity.
abstract: A few coordination compounds of silicon (IV) have been synthesized by the interaction of trimethyl- and triphenyl-chlorosilane with nitrogen-sulphur donor ligands. These compounds are monomeric, as indicated by molecular weight determination, and they behave as nonelectrolytes in dry DMF. From the electronic, infrared, 1H, and 13C NMR spectral results, it has been concluded that in these compounds, silicon is penta-coordinated in a trigonal bipyramidal environment. An assessment of biological activity of these compounds has shown that some of them are very active against P. mirabilis and others against S. viridans bacteria, while all of them show good fungicidal action against F. oxysporum, A. alternata, and A. niger.
authors.affiliation: Department of Chemistry, Indian Institute of Technology, New Delhi, India.
authors.forename: D
authors.initials: D
authors.lastname: Singh
authors.forename: R V
authors.initials: RV
authors.lastname: Singh
authors.forename: N K
authors.initials: NK
authors.lastname: Jha
mesh_terms: D000528:Alternaria / Q000187:drug effects; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D005670:Fusarium / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D017646:Organosilicon Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011513:Proteus mirabilis / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D017646:Organosilicon Compounds