Transdermal nicotine on sleep and PGO spikes.
There is conflicting evidence for the role of nicotine in sleep regulation. This study was undertaken to determine the effects of transdermal nicotine at doses of 17.5, 35 and 52.5 mg on sleep and PGO spike activity. Minor effects were observed on sleep with a general increase in waking. PGO spike activity was abolished by all patches. The results are discussed in terms of the mechanisms involved in the disappearance of PGO spikes as a result of nicotine.
Vazquez
J
J
Depto. de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México.
Guzmán-Marín
R
R
Salín-Pascual
R J
RJ
Drucker-Colín
R
R
D000279:Administration, Cutaneous; D000818:Animals; D001143:Arousal / Q000187:drug effects / Q000502:physiology; D002415:Cats; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000494:pharmacology*; D012895:Sleep, REM / Q000187:drug effects*
D018722:Nicotinic Agonists; D009538:Nicotine