title: Geometric design improvements for femoral graft-artery junctions mitigating restenosis.
abstract: The present study is based on the hypothesis that nonuniform hemodynamics, represented by large time-averaged wall shear stress gradients, trigger abnormal biological processes leading to rapid restenosis, i.e. excessive tissue overgrowth and renewed plaque formation, and hence early graft failure. It implies that this problem may be significantly mitigated by finding graft-artery bypass configurations for which the wall shear stress gradient is approximately zero and hence nearly uniform hemodynamics is achieved. These fluid flow and geometric design considerations are applied to four different end-to-side anastomoses for the distal end of a femoral artery bypass with an appropriate test input pulse and a typical 20-80 flow division. A validated finite-volume code has been used to compute the transient three-dimensional velocity vector fields, wall shear stress distributions and surface contours of the wall shear stress gradients. It is shown that large anastomotic flow areas, small continuously changing bifurcation angles, and smooth junction wall curvatures reduce local time-averaged wall shear stress gradients significantly and hence should mitigate restenosis.
authors.affiliation: Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh 27695-7910, USA.
authors.forename: M
authors.initials: M
authors.lastname: Lei
authors.forename: C
authors.initials: C
authors.lastname: Kleinstreuer
authors.forename: J P
authors.initials: JP
authors.lastname: Archie
mesh_terms: D000465:Algorithms; D000714:Anastomosis, Surgical / Q000009:adverse effects / Q000145:classification / Q000379:methods*; D001157:Arterial Occlusive Diseases / Q000209:etiology / Q000517:prevention & control / Q000601:surgery*; D001783:Blood Flow Velocity; D001808:Blood Vessels / Q000473:pathology / Q000637:transplantation*; D005263:Femoral Artery / Q000473:pathology / Q000601:surgery*; D006085:Graft Survival; D006439:Hemodynamics; D018056:Hemorheology; D006801:Humans; D008955:Models, Cardiovascular; D011673:Pulsatile Flow; D012008:Recurrence; D012039:Regional Blood Flow; D015203:Reproducibility of Results; D013314:Stress, Mechanical