Metabolic interactions between essential and trans-fatty acids.
Trans-fatty acids exacerbate essential fatty acid deficiency in experimental animals by interfering with the metabolism of linoleic (18:2n-6) and alpha-linolenic (18:3n-3) acids and, hence, the eicosanoid production. The interfering effect depends on the type of trans-fatty acid. The detrimental effect of trans-fatty acid, however, apparently disappears when dietary linoleic acid is sufficiently supplemented. Trans-fatty acids appear to disturb fetal growth and birth weight, possibly by the same mechanism.
Sugano
M
M
Laboratory of Food Science, Kyushu University School of Agriculture, Fukuoka, Japan.
Ikeda
I
I
D000818:Animals; D000831:Animals, Newborn; D002648:Child; D015777:Eicosanoids / Q000096:biosynthesis; D005228:Fatty Acids, Essential / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D005333:Fetus; D006801:Humans; D007231:Infant, Newborn; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000378:metabolism; D010743:Phospholipids / Q000096:biosynthesis; D017962:alpha-Linolenic Acid / Q000378:metabolism
D015777:Eicosanoids; D005228:Fatty Acids, Essential; D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids; D010743:Phospholipids; D017962:alpha-Linolenic Acid; D019787:Linoleic Acid