title: Application of the modified relative dose response test to pregnant Indonesian women for assessing vitamin A status.
abstract: OBJECTIVE
  To determine the prevalence of subclinical vitamin A deficiency (vitamin A inadequacy) in Indonesian pregnant women as assessed by the modified relative dose response test.
  
  
  METHODS
  Cross-sectional study of the vitamin A statuses of pregnant (second trimester) women randomly selected from ten different villages.
  
  
  METHODS
  West Java, Indonesia.
  
  
  METHODS
  A group of 144 pregnant women recruited from the local health posts.
  
  
  METHODS
  Modified relative dose response (MRDR) test, serum retinol determination and gynecological examinations.
  
  
  RESULTS
  The mean (s.d.) MRDR ratio was 0.039 +/- 0.031. Of the women tested, the vitamin A status of 17% was provisionally classified as being marginal (subclinically deficient) (MRDR ratio > or = 0.060), of 35% as being uncertain (MRDR ratio between 0.030 and 0.060) and of 48% as being satisfactory (MRDR ratio < or = 0.030).
  
  
  CONCLUSIONS
  If the vitamin A statuses of the 'uncertain' group are also deemed to be unsatisfactory, approximately half of the pregnant Indonesian women tested could benefit from an increased intake of vitamin A.
authors.affiliation: Department of Food Science and Human Nutrition, Iowa State University, Ames 50011, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Tanumihardjo
authors.forename: D
authors.initials: D
authors.lastname: Suharno
authors.forename: D
authors.initials: D
authors.lastname: Permaesih
authors.lastname: Muherdiyantiningsih
authors.forename: A M
authors.initials: AM
authors.lastname: Dahro
authors.lastname: Muhilal
authors.forename: D
authors.initials: D
authors.lastname: Karyadi
authors.forename: J A
authors.initials: JA
authors.lastname: Olson
mesh_terms: D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D009749:Nutrition Surveys; D009752:Nutritional Status; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000453:epidemiology; D015995:Prevalence; D014212:Tretinoin / Q000031:analogs & derivatives*; D014801:Vitamin A / Q000097:blood*; D014802:Vitamin A Deficiency / Q000097:blood* / Q000453:epidemiology
chemical_list: D014801:Vitamin A; C064742:3,4-didehydroretinoic acid; D014212:Tretinoin