title: Quantitative assessment of diastolic filling function: a new Doppler echocardiographic method and in vitro validation.
abstract: The effects of changes in preload and chamber compliance on the transmitral flow pattern was investigated with a fluid dynamics model. A decrease in compliance led to a steepening of the deceleration slope and a shortening of the pressure half-time in both restricted and nonrestricted valves. An increase in the preload led to a longer pressure half-time but did not affect the slope in the restricted valve. However, increased preload led to a shorter pressure half-time and a steeper slope in the nonrestricted valve. A mathematically derived method to measure the net atrioventricular compliance (-[annular area] va/[pvt [flow deceleration rate]]), where va and vt are flow velocities at the mitral anulus and the mitral tip levels) was then proposed. The values obtained by this method showed a strong correlation with true values (r2 = 0.89). A possibility of noninvasive quantitative assessment of diastolic filling function was implied.
authors.affiliation: Third Department of Internal Medicine, Tokyo Medical and Dental University, School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Oniki
authors.forename: S
authors.initials: S
authors.lastname: Shimizu
authors.forename: M
authors.initials: M
authors.lastname: Iwakami
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: F
authors.initials: F
authors.lastname: Numano
mesh_terms: D016275:Atrial Function; D001783:Blood Flow Velocity; D003971:Diastole / Q000502:physiology*; D018619:Echocardiography, Doppler, Pulsed / Q000379:methods*; D006801:Humans; D008955:Models, Cardiovascular; D012039:Regional Blood Flow; D015203:Reproducibility of Results; D016276:Ventricular Function