title: Apoptosis: telling cells their time is up.
abstract: Ligand engagement by the receptor Fas leads to apoptosis. A clue to how this happens comes from the discovery that ligand binding leads to recruitment to Fas of a protease, homologous to interleukin-1 beta converting enzyme, likely to initiate a proteolytic cascade that drives apoptosis.
authors.affiliation: Department of Genetics, Osaka University Medical School, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nagata
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D017173:Caenorhabditis elegans; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D053222:Fas Ligand Protein; D008024:Ligands; D008562:Membrane Glycoproteins / Q000378:metabolism; D008969:Molecular Sequence Data; D019014:fas Receptor / Q000378:metabolism
chemical_list: D053222:Fas Ligand Protein; D008024:Ligands; D008562:Membrane Glycoproteins; D019014:fas Receptor; D003546:Cysteine Endopeptidases