title: Effects of iron and vitamin E administration on some immunological parameters in pigs.
abstract: The effects of intramuscular administration of iron and vitamin E on phagocytic functions of leucocytes and on T-lymphocyte percentages were studied. Twelve pigs with an average body weight (BW) of 40 kg were divided into four treatment groups: +E (20 mg tocopheryl acetate per kg BW); +Fe (10 mg iron dextran per kg BW); +E/+Fe (20 mg tocopheryl acetate + 10 mg iron dextran per kg BW), C (control). Blood samples were collected from the sinus ophthalmicus prior to administration the preparations, and then at 12, 24, 48, 72 hours, and 7 days after administration. The iron injection led to a significant increase (p < 0,05) in plasma iron concentrations in both groups given Ferridextran. An evaluation of the immunological parameters showed the greatest rise in T-lymphocyte percentages as well as in metabolic activity of phagocytes (tetrazolium reduction) in vitamin E treated groups (+E, +E/+Fe) within 24 hours after injection. No interactive effects between vitamin E and iron on the immunological parameters studied were found.
authors.affiliation: Clinic for Internal Diseases of Ruminants and Swine, Veterinary University, Kosice.
authors.forename: P
authors.initials: P
authors.lastname: Mudron
authors.forename: W
authors.initials: W
authors.lastname: Baumgartner
authors.forename: G
authors.initials: G
authors.lastname: Kovac
authors.forename: P
authors.initials: P
authors.lastname: Bartko
authors.forename: I
authors.initials: I
authors.lastname: Rosival
authors.forename: I
authors.initials: I
authors.lastname: Zezula
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D007501:Iron / Q000097:blood / Q000494:pharmacology*; D010586:Phagocytes / Q000187:drug effects; D011897:Random Allocation; D013552:Swine / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000494:pharmacology; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D007501:Iron; D024502:alpha-Tocopherol; D024505:Tocopherols