[Immunologic reaction in patients with arthritis in the course of borreliosis with Lyme disease].
Cell mediated as well as humoral immune response was evaluated in 14 lyme arthritis patients. Significant decrease of T cells percentage was observed in comparison to normal values. It was related particularly to CD4+ subset and resulted in significant decrease of CD4+/CD8+ ratio. Statistically significant increase of B cells percentage was accompanied by elevated concentrations of immunoglobulin M, complement components C3 and C4. Immunoglobulins A and G, as well as circulating immune complexes remained on the normal level. These results indicate suppression of cellular and activation of humoral immune response in patients with Lyme arthritis.
Flisiak
R
R
Klinika Obserwacyjno-Zakaźna Akademii Medycznej w Białymstoku.
Wiercińska-Drapało
A
A
Prokopowicz
D
D
D000293:Adolescent; D000328:Adult; D000917:Antibody Formation; D001168:Arthritis / Q000276:immunology*; D016516:CD4-CD8 Ratio; D003176:Complement C3 / Q000276:immunology; D003181:Complement C4 / Q000276:immunology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000276:immunology; D008193:Lyme Disease / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D003176:Complement C3; D003181:Complement C4; D007074:Immunoglobulin G