Spatial working memory is preserved in rats treated with anabolic-androgenic steroids.
The effects of anabolic-androgenic steroid (AAS) compounds on spatial working memory were evaluated in male rats. Thirty days of administration of a high dose of three individual AAS compounds (17 alpha-methyltestosterone, methandrostenolone, or testosterone cypionate) had no effects on spatial memory or motivation as tested on a delayed non-match-to-sample radial arm maze task. Administration of these AAS compounds at doses within the human abuse range does not impair spatial working memory in rats.
Smith
S T
ST
Department of Physiology, Dartmouth Medical School, Hanover, NH 03755, USA.
Stackman
R W
RW
Clark
A S
AS
D045930:Anabolic Agents / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D008696:Methandrostenolone / Q000494:pharmacology; D008777:Methyltestosterone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013037:Spatial Behavior / Q000187:drug effects / Q000502:physiology*; D013739:Testosterone / Q000031:analogs & derivatives / Q000494:pharmacology; D045165:Testosterone Congeners / Q000494:pharmacology
D045930:Anabolic Agents; D045165:Testosterone Congeners; D013739:Testosterone; D008696:Methandrostenolone; C016131:testosterone 17 beta-cypionate; D008777:Methyltestosterone