title: 3,4-Dimethoxy cinnamic acid tertiary amides: synthesis and evaluation of antiinflammatory and analgesic activities.
abstract: In this study, eight compounds with cinnamoyl amide structure have been synthesized by dicyclohexylcarbodiimide/hydroxybenzotriazol method. The structures of the compounds were elucidated by UV, IR, 1H-NMR, mass spectroscopy and the elementary analysis. The antiinflammatory activities of the synthesized compounds were determined by carrageenan-induced hind paw edema test in mice and the most active compounds were found to be the dimethyl, diethyl and morpholine amide derivatives. Analgesic activities were determined by the modified "Koster" test; diisopentyl and morpholine amide derivatives have shown the highest activity.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Türkiye.
authors.forename: A
authors.initials: A
authors.lastname: Yeşilada
authors.forename: E
authors.initials: E
authors.lastname: Zorlu
authors.forename: F
authors.initials: F
authors.lastname: Aksu
authors.forename: E
authors.initials: E
authors.lastname: Yeşilada
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology; D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D002934:Cinnamates / Q000138:chemical synthesis / Q000494:pharmacology; D051379:Mice; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002934:Cinnamates; C029010:cinnamic acid