5-HT2 receptor gene locus: association with schizophrenia or treatment response not detected.
In view of a reported association between schizophrenia and the 5-HT2 receptor gene locus, as well as an association with treatment refractoriness at this locus, a case-control association study was conducted using a biallelic polymorphism. The distribution of the polymorphism was investigated among patients with schizophrenia (DSM-III-R, n = 174) and unaffected controls (n = 239). No significant differences in genotype distributions or allele frequencies were noted between the two groups. In support of the earlier report, a significant excess of individuals homozygous for allele C2 was noted among patients who responded unsatisfactorily to antipsychotic medication in comparison with the controls (odds ratio 1.78; 95% confidence intervals 1.06, 2.97). However, this difference was not significant following multivariate analysis. This study does not support an association between the 5-HT2 receptor gene locus and schizophrenia or subgroups based on treatment response.
Nimgaonkar
V L
VL
Department of Human Genetics, University of Pittsburgh School of Medicine, PA, USA.
Zhang
X R
XR
Brar
J S
JS
DeLeo
M
M
Ganguli
R
R
D000328:Adult; D000483:Alleles; D014150:Antipsychotic Agents / Q000627:therapeutic use; D044383:Black People / Q000235:genetics; D016022:Case-Control Studies; D015331:Cohort Studies; D004351:Drug Resistance / Q000235:genetics; D005188:False Negative Reactions; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011985:Receptors, Serotonin / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics* / Q000628:therapy; D016896:Treatment Outcome; D044465:White People / Q000235:genetics
D014150:Antipsychotic Agents; D011985:Receptors, Serotonin