Adenosine and the nervous system: clinical implications.
After a review of the metabolism and pharmacology of adenosine, this work will examine the various therapeutic possibilities involving the use of agonists or antagonists of adenosine A1 or A2 receptors in neurological disorders. Promising preclinical results have been obtained with epilepsy, cerebral ischemia, alcoholism, and pain.
Guieu
R
R
URA CNRS 1455, Unité INSERM 374, Institut Jean Roche, Faculté de Médecine Secteur Nord, Marseille, France.
Couraud
F
F
Pouget
J
J
Sampieri
F
F
Bechis
G
G
Rochat
H
H
D000241:Adenosine / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D006801:Humans; D009420:Nervous System / Q000187:drug effects / Q000378:metabolism; D009424:Nervous System Physiological Phenomena; D058906:Purinergic P1 Receptor Agonists; D058915:Purinergic P1 Receptor Antagonists
D058906:Purinergic P1 Receptor Agonists; D058915:Purinergic P1 Receptor Antagonists; D000241:Adenosine