In vivo pulmonary toxicity of cellulose in rats.
Cellulose after a single intratracheal dose (15 mg per animal) brought about fibrosing granulomatous alveobronchiolitis and an increase of IgA production in the bronchoalveolar lavage. Fibrosing alveolitis showed moderate progression as a function of time. With different morphological methods, injury of type I pneumocytes and the incomplete repair of type II pneumocytes were detected. The damage of the alveolar epithelium initiated and activated a series of processes that led to definite pulmonary alterations: pulmonary fibrosis leading to the disintegration of the alveolo-capillary morphological functional unit.
Tátrai
E
E
National Institute of Occupational Health, Budapest, Hungary.
Brozik
M
M
Adamis
Z
Z
Merétey
K
K
Ungváry
G
G
D000818:Animals; D017638:Asbestos, Crocidolite / Q000633:toxicity; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D002482:Cellulose / Q000633:toxicity*; D007070:Immunoglobulin A / Q000032:analysis; D008168:Lung / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D011658:Pulmonary Fibrosis / Q000139:chemically induced*; D051381:Rats
D007070:Immunoglobulin A; D017638:Asbestos, Crocidolite; D002482:Cellulose