title: Diverse molecular provocation of programmed cell death.
abstract: The experimental study and manipulation of programmed cell death has been greatly assisted by the identification of genetic and pharmacological tools that can either induce or block cell lethality. This review discusses new insights into the molecular sensing of perturbations induced by such tools, as well as the possible consequences of this detection in determining cell survival.
authors.affiliation: Department of Biological Chemistry, School of Medicine, University of California at Davis 95616, USA.
authors.forename: I E
authors.initials: IE
authors.lastname: Wertz
authors.forename: M R
authors.initials: MR
authors.lastname: Hanley
mesh_terms: D000682:Amyloid / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D002614:Chelating Agents / Q000494:pharmacology; D003599:Cytoskeleton / Q000737:chemistry; D004249:DNA Damage / Q000235:genetics; D007473:Ion Channels / Q000378:metabolism; D016877:Oxidants / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
chemical_list: D000682:Amyloid; D002614:Chelating Agents; D007473:Ion Channels; D016877:Oxidants; D011956:Receptors, Cell Surface; D014409:Tumor Necrosis Factor-alpha