[Correlation between int-2 oncogene amplification and increased tumor size in breast cancer].
Amplification of the int-2 oncogene was observed in 10 out of 78 (13%) samples of DNA isolated from cells of primary breast tumor. A clinico-morphological examination established a correlation between this molecular-genetical anomaly and tumor size: gene amplification was detected in 1 out 34 (3%) cases of breast tumor under 2 cm and in 9 out 44 (20%) tumors measuring 2 cm and more (p < 0.05). Similarly, a kind of correlation was found between gene amplification and low differentiation of breast cancer cells: enhanced copying ability of the oncogene was registered in 2 out 4 (50%) breast tumors with low cell differentiation, 8 out 69 (12%) tumors with medium cell differentiation, while it was not identified in 5 breast carcinomas with high cell differentiation (p < 0,2).
Chernitsa
O I
OI
Laur
O I
OI
Imianitov
E N
EN
Cheburkin
I V
IV
Belogubova
E V
EV
Iliushik
E S
ES
Zaĭtseva
O A
OA
Togo
A V
AV
Ivanova
O A
OA
Kniazev
P G
PG
Semiglazov
V F
VF
Khanson
K P
KP
D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D005260:Female; D005346:Fibroblast Growth Factors / Q000235:genetics; D005784:Gene Amplification; D006801:Humans; D009857:Oncogenes / Q000235:genetics*
D005346:Fibroblast Growth Factors