Mouse chromosome 9 involvement in beta-CCM-induced seizures.
Analysis of beta-CCM induced seizures in three inbred strains of mice, ABP/Le, C57BL/6J and C57BL/6ByJ, and their F1s and F2s progeny, allowed identification of a putative seizure susceptibility controlling locus on chromosome 9 near the short-ear locus. The involvement of a gene in the medial segment of this chromosome in both seizure activity and GABA-controlled behaviour is discussed.
Clément
Y
Y
Personnalité et Conduites Adaptatives, URA CNRS 1957, Université Paris VI, Hôpital Pitié-Salpêtrière, Paris, France.
Martin
B
B
Venault
P
P
Chapouthier
G
G
D000818:Animals; D002243:Carbolines; D002874:Chromosome Mapping; D003292:Convulsants; D003433:Crosses, Genetic; D004198:Disease Susceptibility; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000235:genetics* / Q000503:physiopathology*
D002243:Carbolines; D003292:Convulsants; C036150:beta-carboline-3-carboxylic acid methyl ester