Mediator release is altered in immunotherapy-treated patients: a 4-year study.
In recent years, it has been possible to demonstrate mediator release into the nasal secretion after nasal allergen challenge in patients with allergic rhinitis. Using the nasal provocation model, we determined whether the mediator release was altered in immunotherapy-treated patients. Seventeen grass-pollen-allergic patients were examined under controlled, reproducible conditions. Serial challenges with increasing doses of grass pollen produced increasing numbers of clinical symptoms and release of mediators such as kinins, TAME-esterase activity, and histamine. Ten patients received a semidepot perennial grass-pollen extract for 4 years. Seven patients served as controls and did not receive immunotherapy during the observation period. Data from the group of patients receiving immunotherapy over the first year already showed a partially significant decline in the maximal mediator release after nasal allergen challenges compared to the results of pretreated challenges, whereas controls did not show any significant changes. Nasal allergen challenges after termination of 4 years' immunotherapy significantly modified the mediator release compared to pretreatment values (TAME-esterase activity P < 0.05, kinins P < 0.01, and histamine P < 0.01). Decrease of mediator release paralleled the symptom-medication scores and quantitative skin prick test. Finally, we could demonstrate a significant correlation between specific IgG increase and mediator decrease in the treated group.
Dokic
D
D
Department of Clinical Immunology and Asthma, Universitätsklinikum Rudolf Virchow, Berlin, Germany.
Nethe
A
A
Kleine-Tebbe
J
J
Kunkel
G
G
Baumgarten
C R
CR
D000293:Adolescent; D000328:Adult; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D004306:Dose-Response Relationship, Immunologic; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006636:Histamine Release; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007167:Immunotherapy; D007705:Kinins / Q000378:metabolism*; D009299:Nasal Provocation Tests; D011058:Pollen / Q000276:immunology*; D011852:Radioallergosorbent Test; D006255:Rhinitis, Allergic, Seasonal / Q000628:therapy*; D012882:Skin Tests
D006634:Histamine H1 Antagonists; D007074:Immunoglobulin G; D007705:Kinins; D007073:Immunoglobulin E; C019724:arginine esterase; D002265:Carboxylic Ester Hydrolases