title: Efficacy of bioadhesive patches in the treatment of recurrent aphthous stomatitis.
abstract: This study evaluated the efficacy of bioadhesive hydrogel patches, made of a pharmaceutical grade cellulose derivative, in the control of pain and as an aid to healing of aphthous ulceration. Patients kept a twice daily ulcer diary to record their pain level on a visual analogue scale. The sensitivity of the test ulcer was assessed by a challenge with pure orange juice as a stimulant before and after application of the patch by the patient. A significant reduction in stimulated pain was recorded following application of the patches to the ulcers (P < 0.01). The patches were found to adhere longer to large ulcers in the early stages of ulceration, when they achieved their maximum protective and pain-attenuating effects. The ulcer size was recorded daily by the patient and patients claimed a reduction in healing time following patch therapy.
authors.affiliation: School of Clinical Dentistry, Queen's University of Belfast, Northern Ireland.
authors.forename: A B
authors.initials: AB
authors.lastname: Mahdi
authors.forename: W A
authors.initials: WA
authors.lastname: Coulter
authors.forename: A D
authors.initials: AD
authors.lastname: Woolfson
authors.forename: P J
authors.initials: PJ
authors.lastname: Lamey
mesh_terms: D000268:Adhesiveness; D000269:Adhesives; D000328:Adult; D001628:Beverages / Q000009:adverse effects; D001672:Biocompatible Materials; D002482:Cellulose / Q000031:analogs & derivatives; D002957:Citrus; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009779:Occlusive Dressings; D010146:Pain / Q000517:prevention & control; D010147:Pain Measurement; D012008:Recurrence; D013281:Stomatitis, Aphthous / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors; D014945:Wound Healing
chemical_list: D000269:Adhesives; D001672:Biocompatible Materials; D002482:Cellulose