Common acute lymphoblastic leukemia preceded by hypercalcemia in an infant.
A case of common acute lymphoblastic leukemia (ALL) preceded by hypercalcemia was observed in an infant. A high blood level of parathyroid hormone related protein (PTH-rP) was detected during the first examination at Ohashi Hospital. Treatment with antineoplastic agents led to complete remission. The blood PTH-rP level decreased as a result of treatment. PTH-rP produced by leukemic cells was though to be the cause of the hypercalcemia.
Ohoishi
S
S
Second Department of Pediatrics, Ohashi Hospital, Toho University School of Medicine, Tokyo, Japan.
Koshibu
T
T
Kazama
H
H
Shinomiya
N
N
Aoki
T
T
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000209:etiology*; D007223:Infant; D044162:Parathyroid Hormone-Related Protein; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D011506:Proteins / Q000378:metabolism*; D012074:Remission Induction
C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins; D002118:Calcium