Effect of central administration of the kappa-opiate receptor agonist U 69.593 on neurohypophyseal hormone levels in blood and cerebrospinal fluid.
Intracerebroventricular (i.c.v.) administration of the kappa-opiate receptor agonist U 69.593 induces a rapid and short lasting suppression of oxytocin (OXT) levels in plasma of water deprived rats, whereas only a tendency towards a suppression of vasopressin (AVP) levels in plasma is observed. No change in neurohypophyseal hormone levels in CSF occurs following i.c.v. administration of U 69.593 at the various times points studied. It is concluded that, upon i.c.v. administration, the suppressive influence of U 69.593 is much weaker than that of the dynorphins and that neurophypophyseal hormone levels in CSF behave differently from those in the peripheral circulation.
van Wimersma Greidanus
T B
TB
Rudolf Magnus Institute for Neurosciences, Department of Pharmacology, Universiteitsweg, Utrecht, The Netherlands.
Janssen
S
S
Frankhuijzen-Sierevogel
J C
JC
Maigret
C
C
van de Heijning
B J
BJ
D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D044482:Benzeneacetamides; D003864:Depression, Chemical; D004399:Dynorphins / Q000494:pharmacology; D008297:Male; D010121:Oxytocin / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D010904:Pituitary Gland, Posterior / Q000187:drug effects* / Q000378:metabolism; D011759:Pyrrolidines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017473:Receptors, Opioid, kappa / Q000819:agonists*; D014868:Water Deprivation / Q000502:physiology; D001615:beta-Endorphin / Q000494:pharmacology
D000700:Analgesics; D044482:Benzeneacetamides; D011759:Pyrrolidines; D017473:Receptors, Opioid, kappa; D001127:Arginine Vasopressin; D010121:Oxytocin; D001615:beta-Endorphin; D004399:Dynorphins; C045444:U 69593