title: Hookworm: developmental biology of the infectious process.
abstract: Hookworms cause severe anemia and malnutrition in developing countries of the tropics, with an estimated one billion people infected worldwide. An in vitro system that models the early events of infection has provided new information about the linkage between the infectious process and the parasite's developmental biology. The cloning and expression of Ancylostoma secreted protein, ASP 1 - a secreted molecule associated with these developmental processes - is an example of how this system allows us to dissect the infectious process at the molecular level.
authors.affiliation: Medical Helminthology Laboratory, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA. hawdonjm@maspo1.mas.yale.edu
authors.forename: J M
authors.initials: JM
authors.lastname: Hawdon
authors.forename: P J
authors.initials: PJ
authors.lastname: Hotez
mesh_terms: D000595:Amino Acid Sequence; D000722:Ancylostoma / Q000472:pathogenicity / Q000502:physiology*; D000724:Ancylostomiasis / Q000453:epidemiology / Q000469:parasitology*; D000818:Animals; D015801:Helminth Proteins / Q000096:biosynthesis* / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D007814:Larva; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
chemical_list: C099548:ASP protein, Ancylostoma caninum; D015801:Helminth Proteins