Suppressive effects of a herbal formula, TBL-1, on type II collagen-induced arthritis in DBA/1J mice.
1. The effects of a formula of traditional Chinese medicine, TBL-1, on collagen-induced arthritis (CIA) were investigated in DBA/1J mice. 2. From 4 weeks after the first immunization with bovine type II collagen (CII), TBL-1 or indomethacin was administered orally for 13 weeks. 3. Clinical scores of CIA were decreased by both TBL-1 and indomethacin intervention compared with the control CII-immunized group. 4. Radiographic scores of phalangeal destruction were markedly improved by TBL-1 intervention (P < 0.001), but indomethacin failed. 5. The suppressive effects of TBL-1, but not indomethacin, were manifested in reduced serum anti-CII antibody titres (P < 0.001). 6. These findings suggest that TBL-1 may play a role in regulating some immune responses in the present arthritis model.
Li
S H
SH
Department of Pharmacology, Shimane Medical University, Izumo, Japan.
Kobayashi
Y
Y
Yamauchi
Y
Y
Gonda
T
T
Tsunematsu
T
T
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001168:Arthritis / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D001323:Autoantibodies / Q000096:biosynthesis; D003094:Collagen; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005528:Foot / Q000473:pathology*; D005552:Forelimb / Q000473:pathology; D006614:Hindlimb / Q000473:pathology; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001323:Autoantibodies; D004365:Drugs, Chinese Herbal; D003094:Collagen; D007213:Indomethacin