Comparative in-vitro activity of cefoperazone/sulbactam and 11 other agents against multidrug resistant Bacteroides fragilis group species.
The activity of cefoperazone/sulbactam was compared with eleven other antimicrobial agents against 91 strains of the Bacteroides fragilis group known to be resistant to clindamycin and/or beta-lactam agents. Sulbactam alone possessed moderate activity against most strains and improved the activity of cefoperazone and ampicillin. Bacteroides distasonis strains were more resistant than other species. There was no correlation between resistance of an isolate to either clindamycin or cefoxitin with resistance to cefoperazone/sulbactam.
Goldstein
E J
EJ
R.M. Alden Research Laboratory, Santa Monica-UCLA Medical Center 90404, USA.
Citron
D M
DM
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001441:Bacteroides fragilis / Q000187:drug effects* / Q000254:growth & development; D002438:Cefoperazone / Q000494:pharmacology; D018550:Cephalosporin Resistance; D018432:Drug Resistance, Multiple; D008826:Microbial Sensitivity Tests; D013407:Sulbactam / Q000494:pharmacology; D018440:beta-Lactam Resistance; D065093:beta-Lactamase Inhibitors
D000900:Anti-Bacterial Agents; D065093:beta-Lactamase Inhibitors; D002438:Cefoperazone; D013407:Sulbactam