title: In-vitro studies of enteric coated diclofenac sodium-carboxymethylcellulose microspheres.
abstract: MIcrospheres containing diclofenac sodium (DS) were prepared using carboxymethylcellulose (CMC) as the main support material (1.0, 2.0, 3.0% (w/v)) and aluminum chloride as the crosslinker. Drug to polymer ratios of 1:1, 1:2 and 1:4 were used to obtain a range of microspheres. The microspheres were then coated with an enteric coating material, Eudragit S-100, efficiency, % yield value, particle sizes an in-vitro dissolution behaviour were investigated. The surface of the enteric coated microspheres seemed to be all covered with Eudragit S-100 from scanning electron microscopy observation. It was also observed that increasing the CMC concentration led to an increase in the encapsulation efficiency, % yield value and particle size and decreased the release rate. Eudragit S-100 coating did not significantly alter the size but the release rate was significantly lower even when the lower concentration solution was used.
authors.affiliation: Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Slhhiye-Ankara, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Arica
authors.forename: M Y
authors.initials: MY
authors.lastname: Arica
authors.forename: H S
authors.initials: HS
authors.lastname: Kaş
authors.forename: A A
authors.initials: AA
authors.lastname: Hincal
authors.forename: V
authors.initials: V
authors.lastname: Hasirci
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry*; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000008:administration & dosage / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D010592:Pharmaceutic Aids / Q000008:administration & dosage / Q000737:chemistry*; D013608:Tablets, Enteric-Coated
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D010592:Pharmaceutic Aids; D013608:Tablets, Enteric-Coated; D004008:Diclofenac; D002266:Carboxymethylcellulose Sodium