title: Induction of Th1 cytokine responses by mycobacterial antigens in leprosy.
abstract: Twelve mycobacterial antigens were compared for induction of gamma interferon (IFN-gamma) secretion by human blood mononuclear cells of patients with leprosy. Fractionated Mycobacterium leprae antigens containing cell wall proteins or cytosolic and membrane proteins induced good IFN-gamma responses in tuberculoid leprosy patients. Lipoarabinomannan from M. tuberculosis Erdman and M. leprae mycolylarabinogalactan peptidoglycan were the poorest IFN-gamma inducers.
authors.affiliation: Molecular Immunology Unit, Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, United Kingdom. h.dockrell@lshtm.ac.uk
authors.forename: H M
authors.initials: HM
authors.lastname: Dockrell
authors.forename: S K
authors.initials: SK
authors.lastname: Young
authors.forename: K
authors.initials: K
authors.lastname: Britton
authors.forename: P J
authors.initials: PJ
authors.lastname: Brennan
authors.forename: B
authors.initials: B
authors.lastname: Rivoire
authors.forename: M F
authors.initials: MF
authors.lastname: Waters
authors.forename: S B
authors.initials: SB
authors.lastname: Lucas
authors.forename: F
authors.initials: F
authors.lastname: Shahid
authors.forename: M
authors.initials: M
authors.lastname: Dojki
authors.forename: T J
authors.initials: TJ
authors.lastname: Chiang
authors.forename: Q
authors.initials: Q
authors.lastname: Ehsan
authors.forename: K P
authors.initials: KP
authors.lastname: McAdam
authors.forename: R
authors.initials: R
authors.lastname: Hussain
mesh_terms: D000942:Antigens, Bacterial / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D015847:Interleukin-4 / Q000096:biosynthesis; D015848:Interleukin-5 / Q000096:biosynthesis; D007918:Leprosy / Q000276:immunology*; D009166:Mycobacterium leprae / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial; D015848:Interleukin-5; D015847:Interleukin-4; D007371:Interferon-gamma