A novel human Mcm protein: homology to the yeast replication protein Mis5 and chromosomal location.
Mcm proteins perform functions related to the regulation of eukaryotic genome replication. Previous work has shown that human cells contain at least five different Mcm proteins. We report now the amino acid sequence of an additional human Mcm protein, p105Mcm, and show that it is homologous to the Schizosaccharomyces pombe protein Mis5. We demonstrate that the gene for protein p105Mcm (HGMW-approved symbol, MCM6) is located on human chromosome 2q14-q21. All six known human Mcm proteins have now been sequenced and compared to their yeast counterparts.
Holthoff
H P
HP
Division of Biology, Universität Konstanz, Germany.
Hameister
H
H
Knippers
R
R
D000595:Amino Acid Sequence; D018797:Cell Cycle Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D005656:Fungal Proteins / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D064151:Minichromosome Maintenance Complex Component 6; D008969:Molecular Sequence Data; D012568:Schizosaccharomyces / Q000235:genetics; D029702:Schizosaccharomyces pombe Proteins; D017386:Sequence Homology, Amino Acid
D018797:Cell Cycle Proteins; D005656:Fungal Proteins; D029702:Schizosaccharomyces pombe Proteins; C103258:MCM6 protein, human; D064151:Minichromosome Maintenance Complex Component 6; C092300:mcm6 protein, S pombe