Formobactin, a novel free radical scavenging and neuronal cell protecting substance from Nocardia sp.
Formobactin, a new free radical scavenger, was isolated from the culture of Nocardia sp. strain ND20. The structure of formobactin was determined to be a member of the nocobactin group antibiotics. Formobactin inhibited lipid peroxidation in rat brain homogenate. Formobactin also showed the activity to suppress L-glutamate toxicity in neuronal hybridoma N18-RE-105 cells.
Murakami
Y
Y
Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
Kato
S
S
Nakajima
M
M
Matsuoka
M
M
Kawai
H
H
Shin-Ya
K
K
Seto
H
H
D000818:Animals; D001381:Azepines / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D002491:Central Nervous System Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D005285:Fermentation; D016166:Free Radical Scavengers / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D015394:Molecular Structure; D009447:Neuroblastoma / Q000188:drug therapy; D009615:Nocardia / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D010080:Oxazoles / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured; D014466:Ultraviolet Rays
D001381:Azepines; D002491:Central Nervous System Agents; D016166:Free Radical Scavengers; D010080:Oxazoles; C102386:formobactin