Treatment of hyperemesis gravidarum with the 5-HT3 antagonist ondansetron (Zofran).
Ondansetron is a 5-hydroxytryptamine receptor antagonist which is known to be a highly effective anti-emetic drug for chemotherapy-associated nausea and vomiting and for postoperative nausea. We report here a case where ondansetron was used in severe hyperemesis gravidarum to avoid parenteral nutrition. The drug was used intermittently in every trimester with no apparent adverse effects on mother or infant.
Tincello
D G
DG
Department of Obstetrics and Gynaecology, Fazakerley Hospital, Liverpool, UK.
Johnstone
M J
MJ
D000328:Adult; D000932:Antiemetics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000188:drug therapy*; D017294:Ondansetron / Q000627:therapeutic use*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D012702:Serotonin Antagonists / Q000627:therapeutic use*
D000932:Antiemetics; D012702:Serotonin Antagonists; D017294:Ondansetron