Mononucleosis-like illness as a manifestation of carbamazepine-induced anticonvulsant hypersensitivity syndrome.
We describe a case of infectious mononucleosis-like as a manifestation of carbamazepine-induced anticonvulsant hypersensitivity syndrome. Patch testing to carbamazepine and phenytoin were positive and negative to phenobarbital. Our results suggest a cell mediated type of immune response in the pathogenesis of this syndrome. Patch testing may be helpful in the diagnosis of anticonvulsant hypersensitivity syndrome caused by carbamazepine.
Maquiera
E
E
Section of Allergy, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
Yañez
S
S
Fernández
L
L
Rodríguez
F
F
Picáns
I
I
Sánchez
I
I
Jeréz
J
J
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D003429:Cross Reactions; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology; D004829:Epilepsy, Generalized / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D007244:Infectious Mononucleosis / Q000175:diagnosis*; D010328:Patch Tests; D010634:Phenobarbital / Q000627:therapeutic use; D010672:Phenytoin
D000927:Anticonvulsants; D002220:Carbamazepine; D010672:Phenytoin; D010634:Phenobarbital