title: HLA-DQA1 subtyping data in the Swiss population.
abstract: Allele- and genotype frequencies for the polymerase chain reaction-based DNA genetic marker HLA-DQA1 were determined previously in a Swiss sample population (n = 200). In this study we subtyped the allele 4 in the same Swiss Caucasian population sample (distinguishing the 4.1 allele from the 4.2 and 4.3 alleles) using the AmpliType PM+ DQA1 PCR Amplification and Typing Kit. No deviations from Hardy-Weinberg equilibrium could be observed. The power of discrimination (Pd) of the HLA-DQA1 locus without subtyping the 4 allele for Swiss Caucasians was 0.931, when subtyping the 4 allele the value is 0.938. The frequency data can be used in forensic analyses to estimate the frequency of a HLA-DQA1 profile in the Swiss population.
authors.affiliation: Institute of Legal Medicine, University of Bern, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Gehrig
authors.forename: M N
authors.initials: MN
authors.lastname: Hochmeister
authors.forename: B
authors.initials: B
authors.lastname: Budowle
authors.forename: R
authors.initials: R
authors.lastname: Reynolds
authors.forename: R
authors.initials: R
authors.lastname: Dirnhofer
mesh_terms: D000483:Alleles; D005828:Genetics, Population; D005838:Genotype; D006683:HLA-DQ Antigens / Q000145:classification / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D006801:Humans; D016133:Polymerase Chain Reaction; D013557:Switzerland
chemical_list: D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen