Distortion of Mendelian recovery ratio for a mouse HSR is caused by maternal and zygotic effects.
An HSR in chromosome 1 which is found in many feral populations of Mus musculus domesticus was shown in previous studies to consist of a high-copy long-range repeat cluster. One such cluster, MUT, showed distorted transmission ratios when introduced by female parents. MUT/+ offspring were preferentially recovered at the expense of +/+ embryos in the progeny of male MUT/+ x female +/+ but were found at the expected 1:1 ratio in reciprocal crosses. Preferential recovery of maternal MUT was due to lethality of postimplantation +/+ embryos. There was no distortion of the recovery ratio in MUT/+ x MUT/MUT progeny: maternal MUT and + clusters were present among live implants at a 1:1 ratio. Maternal and zygotic effects therefore contribute to the phenomenon. The mechanism of their interaction is unknown.
Weichenhan
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D
Institut für Biologie, Medizinische Universität zu Lübeck, Germany.
Traut
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W
Kunze
B
B
Winking
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H
D000818:Animals; D047108:Embryonic Development; D005314:Embryonic and Fetal Development; D005260:Female; D018392:Genomic Imprinting; D006579:Heterozygote; D006720:Homozygote; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D011247:Pregnancy; D015053:Zygote