title: Axial and hip bone mineral density and radiographic changes of osteoarthritis of the knee: data from the Baltimore Longitudinal Study of Aging.
abstract: OBJECTIVE
  To examine the relationship between axial and hip bone mineral density (BMD) and radiographic changes of knee osteoarthritis (OA).
  
  
  METHODS
  BMD of the lumbar spine and/or right hip was measured, using dual photon absorptiometry, in 402 men and 247 women in the Baltimore Longitudinal Study of Aging who had bilateral standing knee radiographs taken between 1984 and 1991. Radiographs were read for features of OA using Kellgren-Lawrence and reliable individual feature scales. The relationship between BMD and radiographic changes of OA was examined using multiple linear regression adjusting for age, body mass index, and smoking. Additional analyses with adjustment for menopausal status and estrogen replacement therapy were performed in a subset of women.
  
  
  RESULTS
  Adjusted mean lumbar spine BMD was higher in subjects with knee osteophytes in both sexes: 1.23 +/- 0.02 vs 1.18 +/- 0.01 g/cm2 (p = 0.02) in men, and 1.12 +/- 0.02 vs 1.08 +/- 0.01 g/cm2 (p = 0.07) in women. There were no differences in levels of adjusted hip BMD by presence of any radiographic features of OA in either men or women.
  
  
  CONCLUSIONS
  These results show that both men and women with radiographic changes of knee OA, specifically osteophytosis, have higher levels of adjusted spine but not hip BMD.
authors.affiliation: Department of Medicine, University of Maryland School of Medicine, USA.
authors.forename: M
authors.initials: M
authors.lastname: Lethbridge-Cejku
authors.forename: J D
authors.initials: JD
authors.lastname: Tobin
authors.forename: W W
authors.initials: WW
authors.lastname: Scott
authors.forename: R
authors.initials: R
authors.lastname: Reichle
authors.forename: T A
authors.initials: TA
authors.lastname: Roy
authors.forename: C C
authors.initials: CC
authors.lastname: Plato
authors.forename: M C
authors.initials: MC
authors.lastname: Hochberg
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D006615:Hip / Q000502:physiology*; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000473:pathology*; D008137:Longitudinal Studies; D008159:Lumbar Vertebrae / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D010024:Osteoporosis / Q000150:complications* / Q000453:epidemiology; D011859:Radiography; D044465:White People