title: Analysis of results of surgery performed over a 20-year period on 500 patients with cancer of the thoracic esophagus.
abstract: This study was conducted to examine the long-term outcome of 500 patients who underwent surgery for cancer of the thoracic esophagus during the past 20 years. Favorable results were obtained with postoperative adjuvant radiation and chemotherapy and there were no surgical deaths in the last 5 years. The mortality rate decreased from 17% prior to 1980 to 5% between 1981 and 1993, this being most probably attributable to the decreased incidence of suture leakage. With respect to changes in surgical techniques, during the initial years we performed intrathoracic anastomosis, after which sternal manubrium resection with anterior mediastinal esophagogastrostomy was carried out. Subsequently, we invented a technique for performing esophagogastrostomy via the posterior mediastinum. The posterior mediastinum was selected as the most physiologic route, based on measurement of tissue oxygen tension. Using blood flow determinations obtained by laser-Doppler velocimetry, we concluded that the effectiveness of thicker gastric tubes was superior to that of thin tubes. Esophagogastrostomy was performed in a shallow field in the cervical region, with the anastomosis ultimately positioned in the superior mediastinum and covered with mediastinal pleura.
authors.affiliation: Second Department of Surgery, Faculty of Medicine, Akita University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Abo
authors.forename: M
authors.initials: M
authors.lastname: Kitamura
authors.forename: M
authors.initials: M
authors.lastname: Hashimoto
authors.forename: K
authors.initials: K
authors.lastname: Izumi
authors.forename: Y
authors.initials: Y
authors.lastname: Minamiya
authors.forename: T
authors.initials: T
authors.lastname: Shikama
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Temma
authors.forename: S
authors.initials: S
authors.lastname: Kamata
authors.forename: R
authors.initials: R
authors.lastname: Saito
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D016629:Esophagectomy / Q000379:methods*; D004946:Esophagostomy / Q000379:methods*; D004947:Esophagus / Q000098:blood supply; D005500:Follow-Up Studies; D005774:Gastrostomy / Q000379:methods*; D006801:Humans; D017078:Laser-Doppler Flowmetry; D011183:Postoperative Complications / Q000209:etiology / Q000401:mortality; D018714:Radiotherapy, Adjuvant; D015996:Survival Rate