Matrix metalloproteinases and the development of cancer.
Proteolytic remodeling of the extracellular matrix is an important aspect of the creation and progression of cancer. Matrix metalloproteinases are important at several points during multi-stage neoplastic progression in tumor cells and responding blood vessels, inflammatory cells and stroma.
Coussens
L M
LM
Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143-0534, USA.
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D004789:Enzyme Activation; D006801:Humans; D008666:Metalloendopeptidases / Q000235:genetics / Q000378:metabolism*; D005810:Multigene Family; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000201:enzymology* / Q000473:pathology
D008666:Metalloendopeptidases