Calcium antagonists in the treatment of hypertension: special clinical considerations.
Calcium antagonists are safe and effective in the treatment of systemic hypertension. Several studies have suggested that calcium antagonists slow the rate of progression of renal disease in hypertensives with underlying renal dysfunction. They may also improve ejection fraction in ischemic myocardial stunning and reduce the number of cardiac events in unstable angina.
Maher
M J
MJ
Division of Renal Diseases, Rhode Island Hospital/Brown University, Providence 02903, USA.
Dworkin
L D
LD
D000787:Angina Pectoris / Q000188:drug therapy; D000789:Angina, Unstable / Q000188:drug therapy; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000494:pharmacology / Q000627:therapeutic use*; D003327:Coronary Disease / Q000188:drug therapy; D018450:Disease Progression; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D017275:Isradipine / Q000627:therapeutic use; D007674:Kidney Diseases / Q000150:complications / Q000473:pathology; D015201:Meta-Analysis as Topic; D009200:Myocardial Contraction / Q000187:drug effects; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D017275:Isradipine