Rapid and high-performance analysis of thyreostatic drug residues in urine using gas chromatography-mass spectrometry.
A more sensitive method was developed using the hyphenated technique of gas chromatography-mass spectrometry (GC-MS) supplementary to the official high-performance thin-layer chromatography (HPTLC) method. Even combined with less efficient extraction and clean-up methods, GC-MS is able to lower the detection limit to less than 50 ppb. The powerful technique of GC-MS-MS is tried out to reduce the detection limit even more, in combination with simplified extraction methods. This time-saving approach combined with the increase in sensitivity is of great importance for a routine technique.
Batjoens
P
P
Department of Veterinary Food Inspection, Faculty of Veterinary Medicine, University of Ghent, Merelbeke, Belgium.
De Brabander
H F
HF
De Wasch
K
K
D013956:Antithyroid Agents / Q000737:chemistry / Q000652:urine*; D004350:Drug Residues / Q000032:analysis* / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry; D008713:Methimazole / Q000737:chemistry / Q000652:urine*; D008779:Methylthiouracil / Q000737:chemistry; D012680:Sensitivity and Specificity; D013997:Time Factors
D013956:Antithyroid Agents; D008713:Methimazole; D008779:Methylthiouracil