title: Life on a string: development of the tetracycline fiber delivery system.
abstract: Development of new drug therapy is difficult for large companies and almost unheard of by individuals. This autobiographical account of the development of the tetracycline fiber delivery system for periodontal therapy (Actisite) relates experiences of a scientist between 1976 and 1994 which lead to FDA approval. In this account, the author acknowledges some of the key people, companies and institutions who were important in this development, makes observations concerning the process itself and offers suggestions for those who might consider commercial development of a scientific concept.
authors.affiliation: Forsyth Dental Center, Boston, MA 02115, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Goodson
mesh_terms: D017277:Drug Approval / Q000266:history; D016503:Drug Delivery Systems / Q000266:history* / Q000295:instrumentation; D049673:History, 20th Century; D006801:Humans; D010510:Periodontal Diseases / Q000188:drug therapy* / Q000266:history; D013752:Tetracycline / Q000008:administration & dosage* / Q000266:history; D014481:United States; D014486:United States Food and Drug Administration; D014753:Vinyl Compounds
chemical_list: D014753:Vinyl Compounds; D013752:Tetracycline; C011566:vinyl acetate