title: The effect of propranolol on sleep bruxism: hypothetical considerations based on a case study.
abstract: The purpose of this study was to investigate the effect of the beta-adrenergic antagonist, propranolol, on the nocturnal masseter muscle activity of a heavy sleep bruxist. Three all-night polysomnographic registrations were performed with bilateral masseter muscle EMG recordings. The first night study served as the baseline night, the second night registration was performed after total sleep deprivation and the third night registration was made with propranolol. Sleep deprivation decreased the masseter contraction (MC) index by 61% and propranolol by 72% when compared to the level of the baseline night. This preliminary observation is in line with our hypothesis suggesting a link between autonomic regulation of circulation and rhythmic activation of masticatory muscles, especially when associated with body movements during sleep.
authors.affiliation: Institute of Dentistry, University of Turku, Finland.
authors.forename: T T
authors.initials: TT
authors.lastname: Sjöholm
authors.forename: I
authors.initials: I
authors.lastname: Lehtinen
authors.forename: S J
authors.initials: SJ
authors.lastname: Piha
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D002012:Bruxism / Q000503:physiopathology*; D004576:Electromyography; D005260:Female; D006801:Humans; D007568:Jaw / Q000187:drug effects / Q000503:physiopathology; D008406:Masseter Muscle / Q000187:drug effects / Q000503:physiopathology; D009068:Movement / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D010507:Periodicity; D011433:Propranolol / Q000494:pharmacology*; D012894:Sleep Stages / Q000502:physiology; D012893:Sleep Wake Disorders / Q000503:physiopathology*
chemical_list: D000319:Adrenergic beta-Antagonists; D011433:Propranolol