[Calcium antagonists and ischemic heart disease].
The authors give a short account about the significance, basic rules in regulation of intracellular (cytosolic) calcium homeostasis, distribution of calcium channels in different organs and characteristics of L channels in cardiovascular system. The different types of calcium channel blockers (dihydropyridines, phenylalkilamines, benzothiazepines), their similarities, dissimilarities (cardio, -vascular selectivity) are discussed. Differences in calcium homeostasis, in sympathetic innervation between vascular smooth- and heart muscle in briefly disputed. The basic role of endothel cell dysfunction in development of ischemic heart disease, the possible mechanisms (potential anti-remodeling, antifissuring, antiischemic, cardioprotective, sympaticolytic effects) of different calcium antagonists in the treatment of patients with ischemic heart disease are reviewed. Potential adverse effects of calcium channel blockers (proischemic, proarrhythmic, procongestive, prohaemorrhagic effects) are also mentioned. Finally the up-date preventive and therapeutic indications of different calcium channel blockers in the clinical management of patients with stable, unstable angina pectoris, silent myocardial ischemia, vasospastic angina, acute myocardial infarction is shortly reported.
Simon
K
K
Fejér Megyei Szent György Kórház, Székesfehérvár, II. Belgyógyászati Osztály.
Vályi
P
P
Szépvölgyi
A
A
Badics
A
A
Böhm
T
T
D000789:Angina, Unstable / Q000188:drug therapy*; D002121:Calcium Channel Blockers / Q000493:pharmacokinetics / Q000627:therapeutic use*; D015220:Calcium Channels / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006706:Homeostasis; D006801:Humans; D017202:Myocardial Ischemia / Q000188:drug therapy*
D002121:Calcium Channel Blockers; D015220:Calcium Channels