title: Anaplastic large cell (CD30/Ki-1+) lymphoma in HIV+ patients: clinical and pathological findings in a group of ten patients.
abstract: We compared the clinical and pathological features of 10 HIV+ CD30+ anaplastic large cell lymphoma (ALCL) patients with 28 HIV+ CD30- non-Hodgkin's lymphoma (NHL) patients. The incidence of ALCL among 38 HIV+ systemic NHL patients was 26%. Clinical features were similar in all the HIV-related NHL cases, but ALCL patients seemed to differ from HIV+ CD30- systemic NHL only in the greater frequency of lung tumours (40% v 21%) without concomitant mediastinal mass, bone marrow (75% v 18%) and gastroenteric involvement (40% v 25%). Among the HIV+ ALCL patients, histologic subtypes did not differ in frequency from ALCL in the general population. The B phenotype was predominant (50%) as in other HIV-related NHL. EBV genoma, studied in all HIV+ ALCL patients, was present in 3/10 by in situ hybridization (ISH) and in 5/10 cases using PCR. The clinical course of lymphomas was similar in CD30 positive and negative NHL patients. Overall survival also was short in our series, particularly in HIV+ ALCL (84 v 188 d), probably because of profound immunodepression of the ALCL patients. Our findings suggest that severe immunodepression due to HIV infection determines-more than any other factor-the clinical features of HIV+ ALCL, making them very similar to those of other high-grade systemic HIV+ NHL.
authors.affiliation: Division of Haematology, Niguarda Cà Granda Hospital, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Nosari
authors.forename: S
authors.initials: S
authors.lastname: Cantoni
authors.forename: P
authors.initials: P
authors.lastname: Oreste
authors.forename: C
authors.initials: C
authors.lastname: Schiantarelli
authors.forename: G
authors.initials: G
authors.lastname: Landonio
authors.forename: S
authors.initials: S
authors.lastname: Alexiadis
authors.forename: L
authors.initials: L
authors.lastname: Gargantini
authors.forename: L
authors.initials: L
authors.lastname: Caggese
authors.forename: M
authors.initials: M
authors.lastname: Gambacorta
authors.forename: E
authors.initials: E
authors.lastname: Morra
mesh_terms: D000328:Adult; D018951:Antigens, CD20 / Q000378:metabolism; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D017730:Ki-1 Antigen / Q000378:metabolism; D017493:Leukocyte Common Antigens / Q000378:metabolism; D016256:Lewis X Antigen / Q000378:metabolism; D016483:Lymphoma, AIDS-Related / Q000378:metabolism / Q000473:pathology*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015996:Survival Rate
chemical_list: D018951:Antigens, CD20; D017730:Ki-1 Antigen; D016256:Lewis X Antigen; D017493:Leukocyte Common Antigens