Effect of taurohyodeoxycholic acid on biliary lipid secretion in man: preliminary report.
Taurohyodeoxycholic acid and tauroursodeoxycholic acid were infused intraduodenally at a rate of 0.8 g/h for three hours in 3 cholecystectomized T-tube patients. Biliary lipid secretion and bile acid composition were evaluated before and after replacement of the endogenous bile acid pool with the two bile acids. As compared to basal values (2.78 +/- 1.67 mM/l), taurohyodeoxycholic acid induced a greater increase in the biliary concentration of phospholipids (4.12 +/- 1.23 mM/l) as compared to tauroursodeoxycholic acid (3.14 +/- 0.98 mM/l). Biliary cholesterol concentration after taurohyodeoxycholic acid (1.89 +/- 0.63 mM/l) was unchanged as compared to the pretreatment period (1.98 +/- 0.58 mM/l), while it decreased significantly after tauroursodeoxycholic acid (0.85 +/- 0.08 mM/I). Biliary cholesterol secreted per unit of bile acid was greater during taurohyodeoxycholic acid than during tauroursodeoxycholic acid, while the opposite was observed for the secretion of phospholipids.
Loria
P
P
Dipartimento Sanità Pubblica, Università di Tor Vergata, Roma, Italy.
Bozzoli
M
M
Angelico
M
M
Bertolotti
M
M
Carubbi
F
F
Concari
M
M
Baiocchi
L
L
Nistri
A
A
Della Guardia
P
P
Romani
M
M
Carulli
N
N
D001646:Bile / Q000187:drug effects / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000737:chemistry*; D002756:Cholagogues and Choleretics / Q000494:pharmacology*; D002784:Cholesterol / Q000032:analysis; D006801:Humans; D050356:Lipid Metabolism; D010743:Phospholipids / Q000032:analysis; D013655:Taurochenodeoxycholic Acid / Q000494:pharmacology; D013657:Taurodeoxycholic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D001647:Bile Acids and Salts; D002756:Cholagogues and Choleretics; D010743:Phospholipids; C083510:taurohyodeoxycholic acid; D013655:Taurochenodeoxycholic Acid; D013657:Taurodeoxycholic Acid; C031655:ursodoxicoltaurine; D002784:Cholesterol