title: Matrix metalloproteinases and the development of cancer.
abstract: Proteolytic remodeling of the extracellular matrix is an important aspect of the creation and progression of cancer. Matrix metalloproteinases are important at several points during multi-stage neoplastic progression in tumor cells and responding blood vessels, inflammatory cells and stroma.
authors.affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143-0534, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Coussens
authors.forename: Z
authors.initials: Z
authors.lastname: Werb
mesh_terms: D004789:Enzyme Activation; D006801:Humans; D008666:Metalloendopeptidases / Q000235:genetics / Q000378:metabolism*; D005810:Multigene Family; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000201:enzymology* / Q000473:pathology
chemical_list: D008666:Metalloendopeptidases