title: Hemodynamic comparison of mild and severe preeclampsia: concept of stroke systemic vascular resistance index.
abstract: Our purpose was to compare baseline hemodynamic parameters of mild and severe preeclampsia. Patients admitted to the Medical University Labor and Delivery Unit with the diagnosis of preeclampsia who had not received prior antihypertensive or magnesium sulfate therapy were recruited for noninvasive hemodynamic monitoring with thoracic electrical bioimpedance. After stabilization in the lateral recumbent position, hemodynamic monitoring was begun. Baseline hemodynamic parameters, mean arterial pressure (MAP), heart rate (HR), systemic vascular resistance index (SVRI), cardiac index (CI), and stroke index (SI) were recorded. Stroke systemic vascular resistance index (SSVRI), the resistance imposed by vasculature on each beat of the heart, was calculated for each patient by multiplying SVRI by HR. For statistical analysis, unpaired Student's t-tests (two-tailed) were utilized (P < 0.01). Forty-one preeclamptic patients (20 mild, 21 severe) were enrolled. Mean gestational age of severe patients was 32.2 +/- 4.0 and of mild patients was 37.0 +/- 3.5. MAP, SBP, diastolic blood pressure, HR, and SSVRI were higher in the severe group. SVRI, CI, cardiac output, and SI did not differ significantly between groups. Severe preclampsia appears to be a more intensely vasoconstricted state than mild preeclampsia. Although CI is inversely proportional to SVRI, increased HR in severe preeclampsia prevents this expected decrease in cardiac output.
authors.affiliation: Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, USA.
authors.forename: J
authors.initials: J
authors.lastname: Scardo
authors.forename: R
authors.initials: R
authors.lastname: Kiser
authors.forename: A
authors.initials: A
authors.lastname: Dillon
authors.forename: B
authors.initials: B
authors.lastname: Brost
authors.forename: R
authors.initials: R
authors.lastname: Newman
mesh_terms: D002307:Cardiography, Impedance; D005260:Female; D005865:Gestational Age; D006339:Heart Rate; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D011225:Pre-Eclampsia / Q000145:classification / Q000175:diagnosis / Q000503:physiopathology*; D011247:Pregnancy; D011446:Prospective Studies; D012720:Severity of Illness Index; D013318:Stroke Volume / Q000502:physiology*; D014655:Vascular Resistance / Q000502:physiology*