title: Genetic and biochemical probes for protein-protein interactions.
abstract: The two-hybrid system is a powerful approach for examining protein-protein interactions. Recently, the utility of the system has been extended to include the genome-wide mapping of protein-protein interactions and the identification of peptide inhibitors of protein interactions. In addition, immunophilins and their chemical ligands are providing useful reagents for generating conditional protein-protein interactions in vivo to dissect intracellular signaling pathways.
authors.affiliation: Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. dsmcnabb@mit.edu
authors.forename: D S
authors.initials: DS
authors.lastname: McNabb
authors.forename: L
authors.initials: L
authors.lastname: Guarente
mesh_terms: D000818:Animals; D001709:Biotechnology; D015335:Molecular Probes; D011485:Protein Binding; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D015335:Molecular Probes; D011506:Proteins; D011994:Recombinant Proteins