Durable remission of a relapsing primary central nervous system lymphoma after autologous bone marrow transplantation.
A 30-year-old patient with a relapsing primary central nervous system lymphoma (PCNSL), was successfully treated with salvage chemotherapy and high-dose therapy including drugs that cross the blood-brain barrier followed by ABMT. Cerebrospinal irradiation was administered after hematological recovery. Six years after transplantation the patient is alive without evidence of recurrent disease with a good neuropsychological status. This result could justify further studies of aggressive management of PCNSL in relapse.
Khalfallah
S
S
Department of Hematology, Centre Henri Becquerel, Rouen, France.
Stamatoullas
A
A
Fruchart
C
C
Proust
F
F
Delangre
T
T
Tilly
H
H
D000328:Adult; D016026:Bone Marrow Transplantation; D001932:Brain Neoplasms / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000473:pathology / Q000628:therapy*; D012008:Recurrence; D014182:Transplantation, Autologous