Experimental study of the biocompatibility of a new glass-ionomer root canal sealer (Ketac-Endo).
Ketac-Endo, a new glass-ionomer cement for endodontic use as root canal sealer, and Tubli-Seal were tested for tissue biocompatibility in rat connective tissue. Forty-four white female Wistar-Furth rats were used. Each sealer was placed in Teflon tubes and implanted subcutaneously. The implants were removed after 5, 15, 60, and 120 days; fixed; and histologically prepared for microscopical evaluation. Mild inflammatory reaction was observed with Ketac-Endo on the 5th day. The connective tissue was infiltrated with plasma cells. Lymphocytes and macrophages were observed. The intensity of the reaction diminished by the 15th day, and this reduction continued progressively through the 60th and 120th days. Severe inflammation with differing extensions of necrosis was observed with Tubli-Seal on the 5th and 15th days, and the material remained irritating even after long-term implantation periods (60 and 120 days).
Kolokuris
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Department of Dental Pathology and Therapeutics, Faculty of Dentistry, Aristotelian University of Thessaloniki, Greece.
Beltes
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Economides
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Vlemmas
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D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity*; D003238:Connective Tissue / Q000187:drug effects* / Q000473:pathology; D003239:Connective Tissue Cells; D005260:Female; D005899:Glass Ionomer Cements / Q000633:toxicity*; D007249:Inflammation / Q000139:chemically induced; D009336:Necrosis; D051381:Rats; D017208:Rats, Wistar; D012387:Root Canal Filling Materials / Q000633:toxicity*; D013997:Time Factors; D015035:Zinc Oxide-Eugenol Cement
D001672:Biocompatible Materials; D005899:Glass Ionomer Cements; C074934:Ketac Endo; D012387:Root Canal Filling Materials; D015035:Zinc Oxide-Eugenol Cement; C048769:tubliseal