title: [Verification of indications for kidney biopsy in children with steroid-dependent nephrotic syndrome].
abstract: The aim of this study was to assess if cytostatic treatment of steroidodependent nephrotic syndrome in children should be preceded by renal biopsy. The result of treatment of 75 children with steroidodependent nephrotic syndrome were analysed. They were randomized for treatment with chlorambucil and cyclophosphamide and divided into two groups. Group I includes 32 children without preceding biopsy, group II, 43 children with established histopatologic diagnosis. Remission was achieved by 25 (78%) children in group I (15 (79%) of 19 treated with chlorambucil and 10(77%) of 13 treated with cyclophosphamide) and 38 (88.4%) in group II (25 (96%) of 26 treated with chlorambucil and 13 (76%) of 17 treated with cyclophosphamide). The results of therapy in children of two groups are comparable. This would indicate that a trial of cytostatic treatment can be started without previous renal biopsy.
authors.affiliation: Dializoterapii i Transplantacji Nerek Instytutu Centrum Zdrowia Dziecka w Warszawie.
authors.forename: E
authors.initials: E
authors.lastname: Idczak-Nowicka
authors.forename: J
authors.initials: J
authors.lastname: Ksiazek
authors.forename: J
authors.initials: J
authors.lastname: Kryński
authors.forename: T
authors.initials: T
authors.lastname: Wyszyńska
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D002699:Chlorambucil / Q000008:administration & dosage / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use*; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D012075:Remission, Spontaneous; D013256:Steroids
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D013256:Steroids; D002699:Chlorambucil; D016572:Cyclosporine; D003520:Cyclophosphamide