[Effect of components of virus-containing allantoic fluid on the stability of influenza virus during storage].
Effects of allantoic fluid fractions (isolated by sedimentation and gel chromatography) on inactivation of influenza virus and lipid peroxidation in viral envelopes and phospholipid liposomes indicate the presence of both components with prooxidant effects enhancing inactivation and of endogenous antioxidants stabilizing the viral activity. The hypothesized "lipid" mechanism of inactivation (suggesting activation of lipid peroxidation in viral envelopes followed by inactivation of viral nucleoprotein) permits a satisfactory interpretation of viral material inactivation.
Poryvaev
V D
VD
Viatkina
T G
TG
Ryzhikov
A B
AB
Sergeev
A N
AN
Iagofarov
S R
SR
D000482:Allantois / Q000378:metabolism / Q000821:virology*; D000818:Animals; D000998:Antiviral Agents; D002642:Chick Embryo; D009980:Influenza A virus / Q000302:isolation & purification* / Q000378:metabolism; D015227:Lipid Peroxidation; D008081:Liposomes; D010743:Phospholipids / Q000378:metabolism; D017382:Reactive Oxygen Species; D014759:Viral Envelope Proteins / Q000378:metabolism
D000998:Antiviral Agents; D008081:Liposomes; D010743:Phospholipids; D017382:Reactive Oxygen Species; D014759:Viral Envelope Proteins