title: The porcine skeletal muscle ryanodine receptor gene structure coding region 1 to 10614 harbouring 71 exons.
abstract: The skeletal muscle ryanodine receptor (RYR1) belongs to a family of calcium release channels that are expressed in different tissues. The RYR1 gene is one of the largest genes characterized, so far, containing a 15253 nucleotide ORF in swine. To study the genomic organization of the porcine skeletal muscle ryanodine receptor gene we have isolated seven genomic fragments spanning 72.7 kb of chromosomal DNA of chromosome 6q12. This region harbours exons 1 to 71 coding for 3538 amino acids (69.6%) of the ryanodine receptor 1.
authors.affiliation: Institute of Veterinary Medicine, University of Goettingen, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Wen
authors.forename: T
authors.initials: T
authors.lastname: Leeb
authors.forename: B
authors.initials: B
authors.lastname: Reinhart
authors.forename: S
authors.initials: S
authors.lastname: Schmoelzl
authors.forename: B
authors.initials: B
authors.lastname: Brenig
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015220:Calcium Channels / Q000235:genetics*; D003001:Cloning, Molecular; D005091:Exons; D008969:Molecular Sequence Data; D009124:Muscle Proteins / Q000235:genetics*; D018482:Muscle, Skeletal / Q000378:metabolism*; D016366:Open Reading Frames; D015183:Restriction Mapping; D019837:Ryanodine Receptor Calcium Release Channel; D013552:Swine / Q000235:genetics*
chemical_list: D015220:Calcium Channels; D009124:Muscle Proteins; D019837:Ryanodine Receptor Calcium Release Channel