title: Oral involvement in chronic graft-versus-host disease after allogeneic bone marrow transplantation.
abstract: We examined 37 patients who had undergone an allogeneic bone marrow transplantation and compared their oral findings to their systemic involvement with chronic graft-versus-host disease. Among the clinical signs and symptoms in their oral region, only the presence of oral lichenoid lesions had a statistically significant relationship to the diagnosis of chronic graft-versus-host disease. The histologic findings in the labial salivary glands and buccal mucosa closely reflected the status of chronic graft-versus-host disease. Statistically, the presence of diffuse and periductal lymphocytic infiltration in labial salivary glands, subepithelial lymphocytic infiltration and epithelial changes in buccal mucosa also showed a significant relationship to the diagnosis of chronic graft-versus-host disease. The present study suggests that a systematic oral examination, especially pathologic examination of the labial salivary glands and buccal mucosa, is useful in evaluating the status of chronic graft-versus-host disease.
authors.affiliation: Second Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kyushu University, Fukuoka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: A
authors.initials: A
authors.lastname: Hiroki
authors.forename: M
authors.initials: M
authors.lastname: Shinohara
authors.forename: H
authors.initials: H
authors.lastname: Gondo
authors.forename: Y
authors.initials: Y
authors.lastname: Ohyama
authors.forename: T
authors.initials: T
authors.lastname: Mouri
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Shirasuna
authors.forename: M
authors.initials: M
authors.lastname: Harada
authors.forename: Y
authors.initials: Y
authors.lastname: Niho
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D002908:Chronic Disease; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology / Q000473:pathology*; D006801:Humans; D017676:Lichen Planus, Oral / Q000209:etiology / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D009061:Mouth Mucosa / Q000473:pathology; D012466:Salivary Gland Diseases / Q000209:etiology / Q000276:immunology / Q000473:pathology; D012470:Salivary Glands, Minor / Q000473:pathology; D014987:Xerostomia / Q000209:etiology / Q000276:immunology / Q000473:pathology