Cholecystokinin (CCK) and C-terminal fragments of CCK: effects of CCK-33, CCK-8 and CCK-4 in the cardiovascular system of diabetic rats.
The effect of cholecystokinin (CCK-33) and its fragments, CCK-8 and CCK-4, on arterial blood pressure and the function of isolated rat heart and catecholamine levels in plasma and from isolated heart tissue in diabetes mellitus were studied. The results indicated that, in diabetes, cardiovascular effects of CCK-33 and CCK-8 are diminished or abolished. Diabetes can change the response of the alpha- and beta-adrenergic system to CCK-33 and CCK-8 and the contents of catecholamines in heart tissue.
Wiśniewska
R J
RJ
Department of Pharmacology, Medical Academy, Białystok, Poland.
Wiśniewski
K
K
D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004837:Epinephrine / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012844:Sincalide / Q000031:analogs & derivatives* / Q000494:pharmacology
C044201:cholecystokinin (26-33); D002766:Cholecystokinin; D012844:Sincalide; D009638:Norepinephrine; D004837:Epinephrine