title: Interferon-alpha inhibits CFU-GM mobilization following chemotherapy and G-CSF administration.
abstract: Changes in routine hematologic data and in circulating granulocyte-macrophage colony-forming units (CFU-GM) during granulocyte colony-stimulating factor (G-CSF) administration were evaluated in non-small cell lung carcinoma (NSCLC) patients treated with a combination of 5-fluorouracil (5-FU) and cisplatin (DDP) with and without the addition of interferon-alpha (IFN-alpha). The patterns of leukocyte changes following chemotherapy plus G-CSF were similar in both the IFN-alpha-inclusive and the IFN-alpha-devoid courses. However, the twofold increase in CFU-GM observed in patients receiving chemotherapy plus G-CSF was completely absent following the course including IFN-alpha. The activity of G-CSF on the hematologic pattern is seemingly affected by its combination with IFN-alpha treatment. Mechanisms of the possible in vivo interaction among IFNs and hematopoietic growth factors remain to be elucidated.
authors.affiliation: Department of Internal Medicine, University of Genoa.
authors.forename: P
authors.initials: P
authors.lastname: Ballarino
authors.forename: G
authors.initials: G
authors.lastname: Castello
authors.forename: R
authors.initials: R
authors.lastname: Lerza
authors.forename: A
authors.initials: A
authors.lastname: Cerruti
authors.forename: E
authors.initials: E
authors.lastname: Arboscello
authors.forename: M
authors.initials: M
authors.lastname: Mencoboni
authors.forename: G
authors.initials: G
authors.lastname: Bogliolo
authors.forename: I
authors.initials: I
authors.lastname: Pannacciulli
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D002945:Cisplatin / Q000627:therapeutic use; D005069:Evaluation Studies as Topic; D005472:Fluorouracil / Q000627:therapeutic use; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood*; D006400:Hematocrit; D006403:Hematologic Tests; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D007962:Leukocytes / Q000187:drug effects; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D018709:Statistics, Nonparametric
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D002945:Cisplatin; D005472:Fluorouracil