Isolation and structure elucidation of five new asterriquinones from Aspergillus, Humicola and Botryotrichum species.
Five new quinone pigments have been discovered from the fermentation broth of Aspergillus, Humicola and Botryotrichum species isolated from different soil samples. These compounds inhibit serine proteases of the coagulation pathway. Their structures which differ in the identity and position of a 5-carbon side chain on the indole moiety have been elucidated based on NMR and FAB-MS experiments.
Mocek
U
U
Natural Products Chemistry Services, Panlabs, Inc., Bothell, WA 98011, USA.
Schultz
L
L
Buchan
T
T
Baek
C
C
Fretto
L
L
Nzerem
J
J
Sehl
L
L
Sinha
U
U
D001230:Aspergillus / Q000737:chemistry / Q000378:metabolism; D001777:Blood Coagulation / Q000187:drug effects; D005658:Fungi / Q000737:chemistry / Q000378:metabolism*; D007211:Indoles / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D003904:Mitosporic Fungi / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D011809:Quinones / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D015842:Serine Proteinase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D012988:Soil Microbiology; D016339:Spectrometry, Mass, Fast Atom Bombardment / Q000379:methods
D007211:Indoles; D011809:Quinones; D015842:Serine Proteinase Inhibitors; C102424:asterriquinone CT1; C102389:asterriquinone CT3; C102390:asterriquinone CT4; C102388:asterriquinone CT5; C035746:asterriquinone