title: Enterobacter sepsis in the newborn--a growing problem in Karachi.
abstract: Enterobacter sepsis is commonly recognized as a hospital-acquired infection in childhood. In a five year prospective surveillance of neonatal sepsis at the Aga Khan University Hospital in Karachi, we identified Enterobacter sepsis in 28/292 (10%) cases, with an incidence of 0.7 per thousand births among inborn infants. There was no significant difference in predisposing factors and clinical features between Enterobacter and other infections. Approximately half (47%) of Enterobacter infections presented within 72 h of birth and the associated mortality was 21%. Increasing resistance to commonly used first- and second-line antibiotics over the last five years was noted. Enterobacter infections are emerging as significant pathogens among cases of neonatal sepsis in Karachi.
authors.affiliation: Department of Paediatrics, Aga Khan University Medical Centre, Karachi, Pakistan.
authors.forename: Z A
authors.initials: ZA
authors.lastname: Bhutta
mesh_terms: D016022:Case-Control Studies; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control; D004352:Drug Resistance, Microbial; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000517:prevention & control; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D017053:Infection Control / Q000379:methods; D007363:Intensive Care Units, Neonatal; D010154:Pakistan / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D018805:Sepsis / Q000382:microbiology* / Q000517:prevention & control