title: Remineralization of root lesions with concentrated calcium and phosphate solutions.
abstract: Remineralization of enamel lesions in vitro by use of sequential treatments with an alkaline (pH 9) phosphate (1 mol/L) solution and slightly acidic (pH 6) calcium (1 mol/L) solution was reported to be relatively ineffective. An analysis of the diffusion processes that may occur during the remineralization treatments suggested that the driving force for diffusion of Ca into the lesion can be increased by making the calcium solution more alkaline than the phosphate solution. In the present study this modified treatment procedure was evaluated for remineralizing root lesions in vitro. Results show that (1) in the control group there was a slight increase in mineral density in the surface region of the lesion, (2) in the experimental group there were significant (p < 0.05) increase in mineral content in the outer 40 microns of the lesion, and (3) in contrast to the finding reported previously, thick mineral deposits on the surface of the root were not observed.
authors.affiliation: American Dental Association Health Foundation, Paffenbarger Research Center, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
authors.forename: L C
authors.initials: LC
authors.lastname: Chow
authors.forename: S
authors.initials: S
authors.lastname: Takagi
mesh_terms: D002118:Calcium / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D004338:Drug Combinations; D005069:Evaluation Studies as Topic; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008852:Microradiography; D008903:Minerals / Q000032:analysis; D010710:Phosphates / Q000494:pharmacology / Q000627:therapeutic use*; D011856:Radiographic Image Enhancement; D011897:Random Allocation; D017213:Root Caries / Q000378:metabolism / Q000628:therapy*; D012969:Sodium Fluoride / Q000494:pharmacology / Q000627:therapeutic use; D014089:Tooth Remineralization / Q000379:methods*; D014092:Tooth Root / Q000378:metabolism
chemical_list: D004338:Drug Combinations; D008903:Minerals; D010710:Phosphates; D012969:Sodium Fluoride; D002118:Calcium