title: Double-blind controlled trial of sertraline versus paroxetine in the treatment of delusional depression.
abstract: OBJECTIVE
  In this study the authors evaluated the efficacy and the tolerability of sertraline and paroxetine in the treatment of delusional depression.
  
  
  METHODS
  Under double-blind conditions, 46 hospitalized patients who met the DSM-III-R criteria for major depression with psychotic features were treated with sertraline or paroxetine for 6 weeks.
  
  
  RESULTS
  The response rates were 75% and 46% for sertraline and paroxetine, respectively. The dropout rate was substantial (41%) in the paroxetine group and was attributable to side effects.
  
  
  CONCLUSIONS
  Selective serotonin reuptake inhibitors administered alone are useful in the treatment of delusional depression.
authors.affiliation: Istituto Scientifico H. San Raffaele, Department of Neuropsychiatric Sciences, University of Milan, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Zanardi
authors.forename: L
authors.initials: L
authors.lastname: Franchini
authors.forename: M
authors.initials: M
authors.lastname: Gasperini
authors.forename: J
authors.initials: J
authors.lastname: Perez
authors.forename: E
authors.initials: E
authors.lastname: Smeraldi
mesh_terms: D015057:1-Naphthylamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003702:Delusions / Q000188:drug therapy* / Q000523:psychology; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000008:administration & dosage / Q000627:therapeutic use*; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D020280:Sertraline; D016896:Treatment Outcome
chemical_list: D015057:1-Naphthylamine; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline