Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth.
We used RT-PCR to detect the expression in mouse molar and incisor tooth germs of 14 of the 19 known members of the Sox family of HMG box-containing transcription factors. These sequences fell into all 6 of the main subdivisions of the Sox family. In general, the relative transcript abundance of the different Sox genes is similar between molar and incisor tooth germs, although 3 low-abundance transcripts were found in only a single tooth type. The expression of Sox genes during tooth development has not been reported previously and further experiments will be required to determine their role in this process.
Stock
D W
DW
Department of Anthropology, Pennsylvania State University, University Park 16802, USA. dws10@psuvm.psu.edu
Buchanan
A V
AV
Zhao
Z
Z
Weiss
K M
KM
D000818:Animals; D015870:Gene Expression; D006609:High Mobility Group Proteins / Q000145:classification / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D014070:Tooth / Q000196:embryology / Q000378:metabolism*
D006609:High Mobility Group Proteins