Topical tretinoin enhances corticosteroid-induced inhibition of tumorigenesis in hairless mice previously exposed to solar simulating radiation.
The role of retinoids in hairless mouse photocarcinogenesis has been studied extensively but remains controversial. By contrast, the role of corticosteroids has hardly been investigated. Many findings indicate an antagonism between the action of these two drugs. To examine these issues, we irradiated hairless mice thrice weekly for 10 weeks with 1.5 minimal erythema doses of solar simulating radiation (UVB + UVA). In the post-UV period, groups of mice were treated topically for 30 weeks with tretinoin, corticosteroid or emollient vehicle alone or with a sequential combination of corticosteroid and tretinoin. A control group remained topically untreated. All three agents, when used alone, significantly inhibited tumorigenesis. The sequential combination produced the greatest inhibition.
Kligman
L H
LH
University of Pennsylvania, School of Medicine, Department of Dermatology, Philadelphia 19104-6142, USA.
Crosby
M J
MJ
D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004357:Drug Synergism; D005260:Female; D051379:Mice; D008812:Mice, Hairless; D009374:Neoplasms, Experimental / Q000517:prevention & control; D009381:Neoplasms, Radiation-Induced / Q000517:prevention & control*; D012878:Skin Neoplasms / Q000517:prevention & control*; D014212:Tretinoin / Q000008:administration & dosage / Q000494:pharmacology*; D014466:Ultraviolet Rays
D000305:Adrenal Cortex Hormones; D000970:Antineoplastic Agents; D014212:Tretinoin