Evidence for the occurrence of depressant EEG effects after stimulation of dopamine D3 receptors: a computerized study in rabbits.
The putative dopamine D3 receptor agonist, (+/-) 7-OH-di-n-propylaminotetralin (+/- 7-OH-DPAT), induced depressant effects on rabbit EEG at the dose of 1 mg/kg i.v. Bromocriptine, a preferential dopamine D2 receptor agonist, induced EEG activation at the dose of 0.5 mg/kg i.v. Although the lack of very selective ligands makes it difficult to discriminate between D2- and D3- dependent effects, these findings suggest that -unlike D2 receptors-dopamine D3 receptors may mediate depressant effects on the electrocorticogram.
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Pharmacology Department, Istituto Superiore di Sanità, Roma, Italy.
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Reggio
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Scotti de Carolis
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D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001971:Bromocriptine / Q000494:pharmacology; D003344:Cortical Synchronization / Q000187:drug effects; D018491:Dopamine Agonists / Q000494:pharmacology*; D004569:Electroencephalography / Q000187:drug effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011817:Rabbits; D017448:Receptors, Dopamine D2 / Q000819:agonists / Q000502:physiology*; D050637:Receptors, Dopamine D3; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D018491:Dopamine Agonists; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D013764:Tetrahydronaphthalenes; D001971:Bromocriptine; C031349:7-hydroxy-2-N,N-dipropylaminotetralin