title: Peripheral lung cancer: screening and detection with low-dose spiral CT versus radiography.
abstract: OBJECTIVE
  To compare low-dose spiral computed tomography (CT) with radiography of the chest for the screening and detection of small peripheral lung cancers in a high-risk population.
  
  
  METHODS
  Posteroanterior and lateral radiographs and low-dose spiral CT scans were obtained twice a year from September 1993 to April 1995 in 1,369 individuals (a total of 3,457 examinations) who were at high risk for lung cancer. Low-dose spiral CT parameters were 120 kvP, 50 mA, 10-mm collimation, and 2:1 pitch.
  
  
  RESULTS
  Peripheral lung cancer was detected in 15 of 3,457 examinations (0.3%). Among the 15 cases, the results of chest radiography were negative in 11 (73%), and the tumors were detected only at low-dose spiral CT. The detection rates of low-dose spiral CT and chest radiography were 0.43% (15 of 3,457 examinations), respectively. Fourteen (93%) of the 15 (exclusion of one pulmonary lung cancer) tumors were stage I.
  
  
  CONCLUSIONS
  Low-dose spiral CT was superior to chest radiography in the screening and detection of peripheral lung cancer in high-risk individuals. Further large-scale studies are warranted, however, to clarify the efficacy and cost-effectiveness of low-dose spiral CT in a randomized, controlled population.
authors.affiliation: Division of Endoscopy, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kaneko
authors.forename: K
authors.initials: K
authors.lastname: Eguchi
authors.forename: H
authors.initials: H
authors.lastname: Ohmatsu
authors.forename: R
authors.initials: R
authors.lastname: Kakinuma
authors.forename: T
authors.initials: T
authors.lastname: Naruke
authors.forename: K
authors.initials: K
authors.lastname: Suemasu
authors.forename: N
authors.initials: N
authors.lastname: Moriyama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003362:Cost-Benefit Analysis; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011829:Radiation Dosage; D013902:Radiography, Thoracic; D013183:Sputum / Q000166:cytology; D014057:Tomography, X-Ray Computed / Q000191:economics / Q000379:methods*