Targeting signal transduction in the discovery of antiproliferative drugs.
Derangements in the signal transduction pathways controlling cell growth can lead to cancer. Two areas of growth factor signaling offer novel opportunities for therapeutic intervention: protein-protein interactions and phosphorylation cascades.
Saltiel
A R
AR
Parke-Davis Pharmaceutical Research, Warner-Lambert Company, 2800 Plymouth Road, Ann Arbor, MI 48105, USA.
Sawyer
T K
TK
D002455:Cell Division / Q000187:drug effects*; D006133:Growth Substances / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*; D018909:src Homology Domains
D006133:Growth Substances; D011494:Protein Kinases