title: [Pneumonitis due to Hangeshashin-to].
abstract: A 72-year-old woman was admitted to our hospital because of dyspnea and abnormal shadows on a chest X-ray film. The X-ray film revealed diffuse reticular and patchy shadows in both lung fields. Drug-induced pneumonitis was suspected, and all drug treatment was stopped. The symptoms were relieved and the X-ray findings improved markedly. In bronchoalveolar lavage fluid, the lymphocyte percentage was high and the CD4/CD8 ratio was low. Microscopic examination of open-lung biopsy specimens showed pneumonitis, dominant lymphocyte invasion within peribronchiolar and alveolar interstitia. The result of leukocyte migration inhibition test was positive for Hangeshashin-to and Byakkokaninjin-to, and lymphocyte stimulation test was positive for Hange, an ingredient of Hangeshashin-to. Based on these findings, we diagnosed as pneumonitis induced by Hangeshashin-to. To our knowledge, there has been no previous report of pulmonary hypersensitivity induced by Hangeshashin-to in Japan.
authors.affiliation: Department of Respiratory Medicine, Nagaoka Red Cross Hospital, Niigata, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Oketani
authors.forename: H
authors.initials: H
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Ebe
mesh_terms: D000368:Aged; D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced*; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D013280:Stomatitis / Q000188:drug therapy
chemical_list: D004365:Drugs, Chinese Herbal