title: Human thioredoxin reductase gene localization to chromosomal position 12q23-q24.1 and mRNA distribution in human tissue.
abstract: Thioredoxin reductase is a member of the pyridine nucleotide-disulfide oxidoreductase family of enzymes. By delivering reducing equivalents to thioredoxin, thioredoxin reductase exerts control over a number of redox-sensitive factors in the cell, including ribonucleotide reductase and several transcription factors. We have localized the human thioredoxin gene to chromosomal position 12q23-q24.1 by in situ hybridization. We have also determined the relative tissue distribution of thioredoxin reductase mRNA as well as thioredoxin mRNA by probing a Northern blot of several human normal tissues.
authors.affiliation: Arizona Cancer Center, University of Arizona, Tucson 85724-5024, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Gasdaska
authors.forename: P Y
authors.initials: PY
authors.lastname: Gasdaska
authors.forename: A
authors.initials: A
authors.lastname: Gallegos
authors.forename: G
authors.initials: G
authors.lastname: Powis
mesh_terms: D002871:Chromosome Banding; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D003001:Cloning, Molecular; D018076:DNA, Complementary; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D012333:RNA, Messenger / Q000378:metabolism; D013880:Thioredoxin-Disulfide Reductase / Q000235:genetics*; D014018:Tissue Distribution
chemical_list: D018076:DNA, Complementary; D012333:RNA, Messenger; D013880:Thioredoxin-Disulfide Reductase