title: Platelets are deposited early post-operatively on the leaflet of a mechanical heart valve in sheep without post-operative anticoagulants or antiplatelet agents. A scanning electron microscopic observation of the pyrolytic carbon surface in a mechanical heart valve.
abstract: Pyrolytic carbon has been used for mechanical heart valves as a thromboresistant, wear resistant, and fatigue resistant material. Thrombosis and thromboembolism, however, remain major mechanical heart valve associated complications and may frequently occur during the early post-operative period. In depth morphologic studies on blood-pyrolytic carbon surface interactions are limited. The purpose of this study was to evaluate the blood compatibility of the pyrolytic carbon surface of St. Jude Medical mechanical heart valves that were implanted in the mitral position of sheep without the administration of post-operative anticoagulants or antiplatelet agents for 2, 4, and 6 weeks. Almost the entire leaflet and orifice ring surfaces were observed by scanning electron microscopy. Although the surfaces appeared clean macroscopically, when observed by electron microscopy, the surface were mottled, mainly by solitary platelets and aggregations. There were only a few leukocytes or red blood cells observed. No fibrin clots were observed on the leaflets. The density of platelet deposition was higher in the vicinity of the pivots and near the edges of the leaflets. The sizes of the platelet aggregations decreased with longer duration. The outer surfaces of the pivot guards were covered by various amounts of deposition composed of platelet aggregations and thrombi. Thus, the administration of antiplatelet agents is recommended during the early post-operative period after mechanical heart valve implantation.
authors.affiliation: Department of Biomedical Engineering, Cleveland Clinic Foundation, OH 44195, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Okazaki
authors.forename: K E
authors.initials: KE
authors.lastname: Wika
authors.forename: T
authors.initials: T
authors.lastname: Matsuyoshi
authors.forename: K
authors.initials: K
authors.lastname: Fukamachi
authors.forename: R
authors.initials: R
authors.lastname: Kunitomo
authors.forename: K S
authors.initials: KS
authors.lastname: Tweden
authors.forename: H
authors.initials: H
authors.lastname: Harasaki
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage; D002244:Carbon; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D008855:Microscopy, Electron, Scanning; D008943:Mitral Valve / Q000601:surgery; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D012756:Sheep; D013499:Surface Properties; D013923:Thromboembolism / Q000209:etiology / Q000517:prevention & control; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control; D013997:Time Factors
chemical_list: D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; D002244:Carbon