title: Hybrid biomaterials based on the interaction of polyurethane oligomers with porcine pericardium.
abstract: Hybrid biomaterials have been produced by the interaction of polyurethane oligomers with both fresh and glutaraldehyde-fixed porcine pericardium. The hybrid biomaterials so formed were translucent with occasional white streaks and/or spots, had increased stiffness (to touch) but remained pliable. No shrinkage temperature was detected for fresh porcine pericardium hybrid up to 100 degrees C compared to porcine pericardium (approximately 67 degrees C) and glutaraldehyde-fixed porcine pericardium (approximately 87 degrees C). Amino acid analysis of the fresh porcine pericardium hybrid showed a reduction in lysine content after active isocyanate-terminated polyurethane oligomers exposure, indicating cross-linking between the polymer and tissue. Histological examination of the hybrid material shows a thin grey coating on both surfaces of the tissue, implying at least surface cross-linking of the tissue with polyurethane. The results suggest that fresh porcine pericardium can be reacted with active isocyanate-terminated polyurethane oligomers to produce hybrid biomaterials with covalent bonding.
authors.affiliation: Department of Chemistry, National University of Singapore, Kent Ridge, Singapore.
authors.forename: W K
authors.initials: WK
authors.lastname: Loke
authors.forename: E
authors.initials: E
authors.lastname: Khor
authors.forename: A
authors.initials: A
authors.lastname: Wee
authors.forename: S H
authors.initials: SH
authors.lastname: Teoh
authors.forename: K S
authors.initials: KS
authors.lastname: Chian
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D004121:Dimethyl Sulfoxide; D004548:Elasticity; D005976:Glutaral; D006018:Glycols; D017953:Isocyanates / Q000032:analysis; D008239:Lysine / Q000032:analysis; D008855:Microscopy, Electron, Scanning; D010496:Pericardium; D011140:Polyurethanes; D013552:Swine
chemical_list: D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D006018:Glycols; D017953:Isocyanates; D011140:Polyurethanes; C047554:polytetramethylene glycol; D008239:Lysine; D005976:Glutaral; D004121:Dimethyl Sulfoxide