The dynamics of cyclin dependent kinase structure.
In the past year, several new crystal structures have provided exciting insights into the conformational changes underlying the regulation of cyclin-dependent kinases. We now understand the structural basis of many of the mechanisms by which cyclin-dependent kinases are regulated, including activation by cyclin binding and phosphorylation, inhibition by the inhibitor p27, and binding by the CKS proteins.
Morgan
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Department of Physiology, Box 0444, University of California, 513 Parnassus Ave, San Francisco, CA 94143, USA. dmorgan@socrates.ucsf.edu
D002455:Cell Division / Q000502:physiology; D002477:Cells / Q000166:cytology / Q000201:enzymology*; D018844:Cyclin-Dependent Kinases / Q000737:chemistry* / Q000378:metabolism*; D010766:Phosphorylation; D011487:Protein Conformation
D018844:Cyclin-Dependent Kinases