Cardiovascular effects of NT-1, a new patch form of nitroglycerin, alone and in combination with nifedipine in conscious dogs.
The cardiovascular effects of NT-1, a new patch form of nitroglycerin, alone and in combination with nifedipine in conscious dogs were examined. NT-1 (2.5 mg kg-1 nitroglycerin) decreased systolic blood pressure by 10-15%, while diastolic blood pressure and heart rate were not affected. Coronary blood flow and calculated rate-pressure product were decreased. These parameter changes occurred at 30 min after NT-1 application and remained constant for 8 h until NT-1 was removed. After administration of NT-1 in combination with nifedipine, systolic blood pressure was significantly decreased to a greater extent, and heart rate and coronary blood flow showed a tendency to increase compared with nifedipine alone. Rate-pressure product was not changed compared with that obtained on administration of nifedipine alone. These results suggest that NT-1 may be applicable as a transdermal sustained release medication, and show that in combination with nifedipine, NT-1 can induce a large increase in coronary blood flow without further increasing rate-pressure product.
Kanda
A
A
Pharmacology Research Laboratories, Taiho Pharmaceutical Co., Ltd, Tokushima, Japan.
Yoshida
M
M
Kanou
M
M
Yamaguchi
K
K
Kyuki
K
K
D000279:Administration, Cutaneous; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D003326:Coronary Circulation / Q000187:drug effects; D003692:Delayed-Action Preparations; D004285:Dogs; D004347:Drug Interactions; D006339:Heart Rate / Q000187:drug effects; D009543:Nifedipine / Q000494:pharmacology*; D005996:Nitroglycerin / Q000008:administration & dosage*; D014665:Vasodilator Agents / Q000008:administration & dosage*
D003692:Delayed-Action Preparations; D014665:Vasodilator Agents; D005996:Nitroglycerin; D009543:Nifedipine