Mutagenicity to the mouse bone marrow by the mouse germ cell mutagen N-propyl-N-nitrosourea.
N-Propyl-N-nitrosourea (PNU) is shown to be active in male mouse bone marrow micronucleus assays when dosed at either 100 or 200 mg/kg in saline. Activity was observed following either intraperitoneal (i.p.) injection or oral gavage. This observation is consistent with the demonstration by Murota and Shibuya of the specific-locus mutagenicity caused by PNU in male mouse spermatogonia when dosed at 200 mg/kg by i.p. injection. These data strengthen further the observation that rodent germ cell mutagens are also mutagenic to rodent somatic cells.
Tinwell
H
H
Zeneca Central Toxicology Laboratory, Alderley Park, Cheshire, UK.
Yendle
J
J
Ashby
J
J
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D009607:Nitrosourea Compounds / Q000633:toxicity*
D009153:Mutagens; D009607:Nitrosourea Compounds; C020796:propylnitrosourea