title: [A Q-fever pneumonia epidemic in Dusseldorf].
abstract: There was an unusually high incidence of atypical pneumonias in the catchment area of the Rhine river near the university of Düsseldorf in July 1994 during a long period of hot and dry weather. The 18 patients described in this paper (5 women and 13 men) complained of sudden onset of fever up to over 40 degrees C, often associated with severe headache and dry cough. Almost all of these patients had previously been healthy and active and of young to middle age (average 38 years) without any bronchopulmonary anamnesis. Radiology revealed that all the patients had in most cases defined pulmonary infiltrates without any specific preference for a particular site. Serology was initially negative, but four weeks later the complement fixation reaction titre was positive for Coxiella burnetii antibodies in 14 patients (78%). All patients became symptom-free within a few days'time when treated with a combination of antibiotics which included doxycycline, whereas the infiltrates receded completely only after several weeks. The occurrence of pulmonary Q-fever in a large northern German conurbation had been rare at that time. Such epidemics, however, were also noted in Berlin (1992) and in Dortmund (1993). The epidemic reported in this article probably originated from one of the frequent flocks of sheep grazing along the banks of the Rhine river near Düsseldorf. The infections were probably acquired by inhalation of airborne organisms in infected aerosols derived from infected sheep, promoted by the long-term very hot and dry weather which was at the same time very windy, leading to an unusually extensive spreading of the pathogens throughout a very large infected aerosol area.
authors.affiliation: Medizinische Klinik B, Heinrich-Heine-Universität Düsseldorf.
authors.forename: K
authors.initials: K
authors.lastname: Schulze
authors.forename: A
authors.initials: A
authors.lastname: Schwalen
authors.forename: R M
authors.initials: RM
authors.lastname: Klein
authors.forename: L
authors.initials: L
authors.lastname: Thomas
authors.forename: M
authors.initials: M
authors.lastname: Leschke
authors.forename: B E
authors.initials: BE
authors.lastname: Strauer
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D000906:Antibodies / Q000097:blood; D016997:Coxiella burnetii / Q000276:immunology; D003430:Cross-Sectional Studies; D004196:Disease Outbreaks; D004318:Doxycycline / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011022:Pneumonia, Rickettsial / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D011778:Q Fever / Q000453:epidemiology*; D012756:Sheep; D015047:Zoonoses / Q000453:epidemiology
chemical_list: D000906:Antibodies; D004318:Doxycycline