Synthesis and biological activity of a conformationally constrained chemotactic gamma-lactam formyl tetrapeptide.
The synthesis and biological activity on human neutrophils of for-Met-(gamma-lactam)-Leu-Phe-OMe [fM(gamma l)LP-OMe], an analogue of the chemotactic fMLP-OMe, are reported. The tetrapeptide evidences chemotactic activity as well as superoxide anion production and lysozyme release, although with lower efficacy when compared with the parent tripeptide.
Cavicchioni
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Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Italy.
Breveglieri
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Reali
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Spisani
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D002630:Chemotactic Factors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D003594:Cytoplasmic Granules / Q000187:drug effects / Q000201:enzymology; D003911:Dextrans / Q000737:chemistry; D006801:Humans; D066298:In Vitro Techniques; D008968:Molecular Conformation; D009113:Muramidase / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism
D002630:Chemotactic Factors; D003911:Dextrans; D010455:Peptides; D013481:Superoxides; D009113:Muramidase