The effect of intranasal fluticasone propionate on the diving reflex in patients with non-eosinophilic non-allergic rhinitis.
The usual nasal response to head submersion in aquatic mammals is an increase in resistance to airflow, the so-called "diving reflex". Although less well-developed in humans, it is nevertheless present. It is likely to occur due to a relative increase of parasympathetic over sympathetic control of the nasal vasculature. Non-eosinophilic non-allergic rhinitis is thought to be due to a similar imbalance and we have attempted to establish whether the diving reflex is abnormal in this condition and whether intranasal fluticasone propionate for 6 weeks has any effect in modifying the nasal response.
Cook
J A
JA
Department of Otolaryngology, University of Liverpool, United Kingdom.
Hamilton
J W
JW
Jones
A S
AS
D000281:Administration, Intranasal; D000403:Airway Resistance / Q000187:drug effects; D000730:Androstadienes / Q000008:administration & dosage* / Q000627:therapeutic use; D018926:Anti-Allergic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D016022:Case-Control Studies; D003080:Cold Temperature; D004242:Diving; D005260:Female; D000068298:Fluticasone; D006801:Humans; D008297:Male; D012018:Reflex / Q000187:drug effects* / Q000502:physiology; D012220:Rhinitis / Q000188:drug therapy* / Q000503:physiopathology*; D013997:Time Factors
D000730:Androstadienes; D018926:Anti-Allergic Agents; D000068298:Fluticasone