title: Incongruent follicular development reduces gamete intrafallopian transfer pregnancy rate.
abstract: OBJECTIVE
  To test the null hypothesis that asymmetric or incongruent follicular development does not influence GIFT pregnancy rates (PRs).
  
  
  METHODS
  A prospective comparative study.
  
  
  METHODS
  Tertiary referral center for infertility.
  
  
  METHODS
  Ninety-three consecutive infertile patients having GIFT.
  
  
  METHODS
  Controlled ovarian hyperstimulation and GIFT.
  
  
  METHODS
  The incongruity ratio as a parameter of the asymmetry in follicular development and the clinical PR.
  
  
  RESULTS
  An inverse relationship was observed between the degree of incongruity and the clinical PRs. In patients with an incongruity ratio < 1.5, the clinical PR was 56.1%. In patients with an incongruity ratio > or = 1.5, the clinical PR was only 17.3%.
  
  
  CONCLUSIONS
  Incongruent follicular development during controlled ovarian hyperstimulation has a marked negative influence on the outcome of GIFT cycles. Factors such as side of the gamete transfer and oocyte quality did not account for the observed differences.
authors.affiliation: Monash IVF, Epworth Hospital, Richmond, Victoria, Australia.
authors.forename: L
authors.initials: L
authors.lastname: Rombauts
authors.forename: D
authors.initials: D
authors.lastname: Webster
authors.forename: C E
authors.initials: CE
authors.lastname: Wood
authors.forename: D L
authors.initials: DL
authors.lastname: Healy
mesh_terms: D000328:Adult; D005260:Female; D015181:Gamete Intrafallopian Transfer; D006801:Humans; D006080:Ovarian Follicle / Q000000981:diagnostic imaging / Q000502:physiology*; D010053:Ovary / Q000503:physiopathology; D018873:Pregnancy Rate; D011446:Prospective Studies; D013268:Stimulation, Chemical; D014463:Ultrasonography