Developmental effects of magnetic field (50 Hz) in combination with ionizing radiation and chemical teratogens.
The influence of a 50 Hz magnetic field (MF) on avian and mammalian embryogenesis, the MF level and vector, as well as the effect of exposure to MF (50 Hz, 10 mT) in combination with X-rays has been recently reported [2,3]. No significant alterations of chick or rat embryogenesis were found after repeated exposures to 50 Hz MF at 10 mT or 6 microT or with different vectors. However, X-ray chick embryotoxicity was significantly affected by repeated exposures of developing organisms to MF. A strong dependence of effect on the type of interaction was revealed. A decrease of X-ray induced teratogenicity was observed when MF preceded X-ray exposure (indirect interaction), while MF exposure applied immediately after X-ray radiation (direct interaction) non-significantly potentiated adverse developmental effects of ionizing radiation. This study deals with the effects of MF in combination with insulin or tetracycline. Exposure of chick embryos to MF influenced the sensitivity of embryonic morphogenetic systems to the subsequently administered chemical teratogens, insulin and/or tetracycline. A protective effect of MF was detected similarly as in the case of indirect interaction with ionizing radiation.
Pafková
H
H
National Institute of Public Health, Praha, Czech Republic.
Jerábek
J
J
Tejnorová
I
I
Bednár
V
V
D000014:Abnormalities, Drug-Induced / Q000517:prevention & control*; D000818:Animals; D002642:Chick Embryo / Q000002:abnormalities / Q000187:drug effects* / Q000528:radiation effects*; D004574:Electromagnetic Fields / Q000009:adverse effects*; D007328:Insulin / Q000633:toxicity; D013723:Teratogens / Q000633:toxicity*; D013752:Tetracycline / Q000633:toxicity; D014965:X-Rays / Q000009:adverse effects
D007328:Insulin; D013723:Teratogens; D013752:Tetracycline