Kill kinetics of antimicrobial agents against Helicobacter pylori.
We evaluated the activity of clarithromycin, 14-OH clarithromycin, amoxycillin, bismuth, metronidazole and ciprofloxacin against six strains of Helicobacter pylori to determine if there were differences in response to these antimicrobial agents during growth in vitro. Clarithromycin and its 14-hydroxy-metabolite exhibited an early bactericidal activity with at least a 3 log10 reduction after 2-8 incubation. Exposure to bismuth, ciprofloxacin and metronidazole resulted in a > 3 log reduction by 24 h with the greatest decrease in viability occurring between 8 and 24 h. The viable count of three strains was reduced by a 1-2 log10 after 24 h exposure to amoxycillin and by a > 3 log10 after 48 h.
Flamm
R K
RK
Abbott Laboratories, Anti-infective Research Division of Pharmaceutical Discovery, Abbott Park, IL 60064-3500, USA.
Beyer
J
J
Tanaka
S K
SK
Clement
J
J
D000658:Amoxicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D017291:Clarithromycin / Q000031:analogs & derivatives / Q000494:pharmacology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D007700:Kinetics; D016015:Logistic Models; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009942:Organometallic Compounds / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D009942:Organometallic Compounds; C056228:14-hydroxyclarithromycin; D008795:Metronidazole; D002939:Ciprofloxacin; D000658:Amoxicillin; D017291:Clarithromycin; C002791:bismuth tripotassium dicitrate