[Chemotherapy in elderly patients with bronchogenic cancers].
Bronchogenic carcinoma is the most frequent carcinoma of men and affect more often old patients. Medical oncologists and pneumologists don't treat or treat with less intensive therapies patients older than 70 or 75 years compared with younger patients. That behaviour is not based on scientific criterias. The majority of the published studies are in fact retrospective with a lot of biases (especially selection of patients). It doesn't seem that nephrotoxicity is greater in older patients with cisplatinum but the neurological, digestive and medullary toxicities are more important in older than in younger patients.
Souquet
P J
PJ
Service de Pneumologie, CH Lyon Sud, Pierre-Bénite.
Lombard-Bohas
C H
CH
Freyer
G
G
Bombaron
P
P
Gerinière
L
L
Bernard
J P
JP
D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D015982:Bias; D002283:Carcinoma, Bronchogenic / Q000188:drug therapy*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D018288:Carcinoma, Small Cell / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008136:Longevity; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D018579:Patient Selection; D011379:Prognosis; D011788:Quality of Life; D012107:Research Design; D012189:Retrospective Studies
D000970:Antineoplastic Agents