title: Threading your way to protein function.
abstract: It is still very difficult to determine the function of a protein from its sequence. One potential solution to the problem combines the concept of enzyme superfamilies with modern methods of protein structure prediction. Active-site templates can be used as search tools to identify new members of the superfamilies.
authors.affiliation: The Pennsylvania State University, Department of Chemistry, 152 Davey Laboratory, University Park, PA 16802, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Firestine
authors.forename: A E
authors.initials: AE
authors.lastname: Nixon
authors.forename: S J
authors.initials: SJ
authors.lastname: Benkovic
mesh_terms: D000595:Amino Acid Sequence; D001665:Binding Sites; D004798:Enzymes / Q000737:chemistry / Q000502:physiology; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry / Q000502:physiology*; D013329:Structure-Activity Relationship
chemical_list: D004798:Enzymes; D011506:Proteins