title: [A quantitative study of regional cerebral blood flow in patients with dementia of Alzheimer type using single photon emission computed tomography--clinical application of the IMP autoradiographic method (IMP ARG method)].
abstract: We quantitatively measured regional cerebral blood flow (rCBF) in 37 patients with dementia of Alzheimer type (DAT) to investigate the clinical utilities of the N-isopropyl-p-[123I]iodoamphetamine autoradiographic method (IMP ARG method) that is a quantitative method more simplified and less invasive for IMP-SPECT developed by Iida et al. A given standard input function and a given value of distribution volume (Vd) used for the rCBF measurement of this method were calculated from the dynamic study by six normal volunteers. Mean values [SD] of rCBF (ml/ 100 g/min) in the Cerebral Cortex were 49.0 [6.0] in the controls (n = 20), 42.6 [5.9] in mild DAT group (n = 14), 36.7 [5.5] in moderate DAT group (n = 12), and 26.4 [7.5] in severe DAT group (n = 11), respectively. These values were significantly different between each neighboring group. Moreover, the correlations between the score by the Hasegawa dementia scale (HDS-R) and each rCBF were significant in the temporal, parietal, and frontal cortex. These findings suggest that the rCBF measurement in IMP-SPECT using this method is useful for the diagnosis of the clinical severity in patients with DAT.
authors.affiliation: Second Department of Internal Medicine, Nippon Medical School First Hospital.
authors.forename: Y
authors.initials: Y
authors.lastname: Koshi
authors.forename: S
authors.initials: S
authors.lastname: Kitamura
authors.forename: T
authors.initials: T
authors.lastname: Komiyama
authors.forename: O
authors.initials: O
authors.lastname: Sakayori
authors.forename: Y
authors.initials: Y
authors.lastname: Komaba
authors.forename: M
authors.initials: M
authors.lastname: Ohyama
authors.forename: T
authors.initials: T
authors.lastname: Tsuganesawa
authors.forename: M
authors.initials: M
authors.lastname: Mishina
authors.forename: A
authors.initials: A
authors.lastname: Ishiwata
authors.forename: H
authors.initials: H
authors.lastname: Soya
authors.forename: M
authors.initials: M
authors.lastname: Nakazawa
authors.forename: A
authors.initials: A
authors.lastname: Terashi
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D000662:Amphetamines; D001345:Autoradiography; D001921:Brain / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008297:Male; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine