Regulation and interactions of transforming growth factor-beta with cardiovascular cells: implications for development and disease.
1. Transforming growth factors-beta (TGF-beta) are multifunctional proteins that regulate cell growth, differentiation, migration and extracellular matrix production and have an important role in embryonic development and tissue remodelling. 2. The diverse biological actions of TGF-beta are elicited following their interaction with type I and type II TGF-beta receptors, both of which are transmembrane serine/threonine kinases, suggesting an important role for protein phosphorylation in the mechanism of action of these cytokines on the growth of cells and their extracellular environment. 3. Alterations in TGF-beta gene expression and action in various cell types associated with the cardiovascular system may contribute to the pathophysiology of a number of diseases, such as hypertension, atherosclerosis and restenosis, as well as the development of cardiac abnormalities.
Saltis
J
J
Baker Medical Research Institute, Alfred Hospital, Prahran, Victoria, Australia.
Agrotis
A
A
Bobik
A
A
D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology; D002319:Cardiovascular System / Q000187:drug effects* / Q000196:embryology / Q000378:metabolism; D066246:ErbB Receptors / Q000819:agonists* / Q000502:physiology; D006331:Heart Diseases / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D018125:Receptors, Transforming Growth Factor beta / Q000819:agonists* / Q000502:physiology; D015290:Second Messenger Systems / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000096:biosynthesis / Q000494:pharmacology*
D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta; D066246:ErbB Receptors