Excretion of oral 9-cis-retinoic acid in the rat.
We have studied excretion of oral 9-cis-retinoic acid in urine and feces in vigil rats and in bile in anesthetized rats. A proportion of 53 +/- 13% of the dose of 9-cis-retinoic acid administered was eliminated through the feces in 72 hr, and the urinary excretion was negligible. The prevalent form of elimination in feces and urine was the unchanged compound. Low biliary excretion was, for the most part, composed of metabolites.
Disdier
B
B
Laboratoire de Toxicologie et Pharmacie Clinique, Faculté de Pharmacie, Marseille, France.
Bun
H
H
Placidi
M
M
Durand
A
A
D000284:Administration, Oral; D000077556:Alitretinoin; D000818:Animals; D001646:Bile / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014212:Tretinoin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine
D000077556:Alitretinoin; D014212:Tretinoin