title: Airway closure and intraoperative hypoxaemia: twenty-five years later.
abstract: OBJECTIVE
  The literature describing the pulmonary mechanisms of increased PA-PaO2 during general anaesthesia was examined to define the role of airway closure and sub-radiological atelectasis.
  
  
  METHODS
  A Medline search was designed to include articles dealing with the stated purpose, which is thus selective rather than a meta-analysis. The MeSH consisted of the following words: Anesthesia: general/inhalational; Pulmonary gas exchange; Ventilation:perfusion ratio; Lung Physiology; Lung Volume measurements; Closing Volume/Capacity; Functional Residual Capacity; Atelectasis; Diaphragm. Also, Dr H. Rothen and Prof. G. Hedenstierna supplied raw data.
  
  
  RESULTS
  Changes in shape and dimensions of the thorax and abdomen immediately after induction of anaesthesia result in marked alterations in the efficiency of oxygenation. Three pathways can be described: increased effects of airway closure, increased low ventilation: perfusion in dependent lung zones, and frank atelectasis. The magnitude of the alterations is determined by the patients' age and body habitus. Some of the changes may carry-over into the postoperative period. The data suggest that increasing tidal volume during anaesthesia will reduce the effects of airway closure and that vital capacity breaths will re-expand atelectatic areas.
  
  
  CONCLUSIONS
  Airway closure and atelectasis contribute equally to the increased ventilation: perfusion mismatching that occurs during general anaesthesia.
authors.affiliation: Department of Anaesthesia, SMBD-Jewish General Hospital, Montreal, PQ.
authors.forename: R M
authors.initials: RM
authors.lastname: Wahba
mesh_terms: D006801:Humans; D000860:Hypoxia / Q000209:etiology*; D007431:Intraoperative Complications / Q000209:etiology*; D001261:Pulmonary Atelectasis / Q000150:complications; D014692:Ventilation-Perfusion Ratio