Replication of herpes simplex virus type 1 and 2 in the medulla of the adrenal gland after vaginal infection of mice.
After vaginal infections of mice with neuroinvasive strains of herpes simplex virus type 1 and 2 (HSV-1, HSV-2) virus replicates in the epithelium of the vagina, in the paravaginal ganglia, in the spinal cord and finally in the brain and in the adrenal glands. However, viral antigens could be demonstrated only in the medulla of the adrenal glands but not in the cortex, as assessed by immunohistochemistry (IHC). HSV could not be isolated from liver, spleen, uterus, and ovaries. This contrasts to the intraperitoneal (i.p) route of infection with replication in different visceral organs including the adrenal gland's cortex.
Podlech
J
J
Institute of Virology, Johannes Gutenberg-University, Mainz, Federal Republic of Germany.
Hengerer
F
F
Fleck
M
M
Walev
I
I
Falke
D
D
D000313:Adrenal Medulla / Q000473:pathology / Q000821:virology*; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis*; D002540:Cerebral Cortex / Q000473:pathology / Q000821:virology; D002522:Chlorocebus aethiops; D005260:Female; D018259:Herpesvirus 1, Human / Q000276:immunology / Q000302:isolation & purification* / Q000502:physiology; D018258:Herpesvirus 2, Human / Q000276:immunology / Q000302:isolation & purification* / Q000502:physiology; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D013116:Spinal Cord / Q000473:pathology / Q000821:virology; D014621:Vagina / Q000473:pathology / Q000821:virology; D014709:Vero Cells; D014779:Virus Replication
D000956:Antigens, Viral