title: Potent and selective thrombin inhibitors incorporating the constrained arginine mimic l-3-piperidyl(N-guanidino)alanine at P1.
authors.affiliation: Corvas International Inc., San Diego, California 92121-1102, USA. odile_levy@corvas.com
authors.forename: O E
authors.initials: OE
authors.lastname: Levy
authors.forename: J E
authors.initials: JE
authors.lastname: Semple
authors.forename: M L
authors.initials: ML
authors.lastname: Lim
authors.forename: J
authors.initials: J
authors.lastname: Reiner
authors.forename: W E
authors.initials: WE
authors.lastname: Rote
authors.forename: E
authors.initials: E
authors.lastname: Dempsey
authors.forename: B M
authors.initials: BM
authors.lastname: Richard
authors.forename: E
authors.initials: E
authors.lastname: Zhang
authors.forename: A
authors.initials: A
authors.lastname: Tulinsky
authors.forename: W C
authors.initials: WC
authors.lastname: Ripka
authors.forename: R F
authors.initials: RF
authors.lastname: Nutt
mesh_terms: D000818:Animals; D000991:Antithrombins / Q000737:chemistry*; D001665:Binding Sites; D002851:Chromatography, High Pressure Liquid; D006146:Guanidines / Q000737:chemistry*; D006801:Humans; D010880:Piperidines / Q000737:chemistry*; D051381:Rats; D013237:Stereoisomerism; D013917:Thrombin / Q000737:chemistry
chemical_list: D000991:Antithrombins; D006146:Guanidines; D010880:Piperidines; C102318:alpha-((1-aminoiminopiperidin-3-yl)methyl)-N-(2-(3-benzylsulfonamido-2-oxopiperidin-1-yl)-1-oxoethyl)glycinal; D013917:Thrombin