Nucleolar organizer regions in pituitary adenomas.
In this study, thirty-two non-functional and eighteen functional pituitary adenomas were analysed for the presence of argyrophilic nucleolar organizer regions (Ag-NORs) in paraffin sections, using an one-step silver-colloidal staining method. Differences in the mean Ag-NOR numbers of functional pituitary adenomas were statistically significant than those of non-functional pituitary adenomas. It is being emphasised that evaluation of Ag-NOR count is a more reliable index than the presence of mitotic figures in predicting the proliferative activity as well as possibility of recurrence in a patient with pituitary adenoma.
Radhakrishnan
V V
VV
Department of Pathology, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Trivandrum, India.
Radhakrishnan
N S
NS
Misra
B K
BK
Rout
D
D
D000236:Adenoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009697:Nucleolus Organizer Region / Q000473:pathology*; D010911:Pituitary Neoplasms / Q000473:pathology*; D012834:Silver; D013194:Staining and Labeling
D012834:Silver