title: Heat shock protein-based cancer vaccines and related thoughts on immunogenicity of human tumors.
abstract: Heat shock proteins (HSPs) are associated in vivo with the entire repertoire of peptides (antigenic and otherwise) generated within that cell. Immunization with such non-covalent HSP-peptide complexes is unusually efficient in eliciting cellular immune responses against the antigenic peptides associated with the HSPs. This broad and general principle is the basis for a new generation of vaccines against cancers and infectious diseases and circumvents the need for identification of the T-cell epitopes for any given cancer or infectious agent.
authors.affiliation: Department of Biological Sciences, Fordham University, Bronx, NY 10458, USA.
authors.forename: N E
authors.initials: NE
authors.lastname: Blachere
authors.forename: P K
authors.initials: PK
authors.lastname: Srivastava
mesh_terms: D000951:Antigens, Neoplasm / Q000276:immunology*; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy; D014614:Vaccines, Synthetic / Q000276:immunology / Q000494:pharmacology*
chemical_list: D000951:Antigens, Neoplasm; D006360:Heat-Shock Proteins; D014614:Vaccines, Synthetic