Bone marrow uptake of fluorine-18-fluorodeoxyglucose following treatment with hematopoietic growth factors: initial evaluation.
Hematopoietic growth factors (HGF) such as G-CSF and GM-CSF stimulate cell growth of the bone marrow and thereby mitigate the myelotoxic effect of chemotherapy. Using 18F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) for therapy response monitoring of patients with small-cell lung cancer, both an extension and an intensification of thoracic bone marrow uptake were noted in patients treated with HGF (n = 5) compared to those patients without HGF supplementation (n = 11). FDG uptake was a very sensitive marker of stimulated hematopoiesis, and both the extension and the intensification of uptake have to be noted during HGF therapy.
Knopp
M V
MV
German Cancer Research Center (DKFZ), Department of Radiological Diagnostics and Therapy, Heidelberg, Germany. M.Knopp@dkfz-heidelberg.de
Bischoff
H
H
Rimac
A
A
Oberdorfer
F
F
van Kaick
G
G
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001853:Bone Marrow / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism*; D018288:Carcinoma, Small Cell / Q000188:drug therapy; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D004311:Double-Blind Method; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D016298:Hematopoietic Cell Growth Factors / Q000627:therapeutic use*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014055:Tomography, Emission-Computed
D000970:Antineoplastic Agents; D005462:Fluorine Radioisotopes; D016298:Hematopoietic Cell Growth Factors; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose