title: Ventricular protection against atrial arrhythmias in DDD pacing based on a statistical approach: clinical results.
abstract: Atrial arrhythmias (AA) are commonly encountered in DDD paced patients. Newer dual chamber pacemakers (PM) possess mode switching functions that convert pacing to an asynchronous mode when AAs are detected. The lack of a reliable mode switch leading to rapid, irregular ventricular responses may result from AA undersensing. To avoid this the DDDR PM Chorum 7234 Ela Medical AA diagnosis is based on a statistical approach: the PM constantly compares arrhythmic and sinus cycles and, based on "strong" and "weak" criteria, provides for rapid or slower mode switch. The aim of the study was to evaluate the efficiency and reliability of these two criteria. Thirty-one patients with a Chorum 7234 implanted for AV block (11), sinus dysfunction (10), both (5), or hypertrophic obstructive cardiomyopathy (5) were evaluated at 24 hours and 1 month using the internal memory (IM) of the PM, surface 24-hour Holter recordings, and exercise testing. Interrogation of the IM on the first day of study showed that 8 patients had mode switching episodes, based only on the strong criterion confirmed by the surface Holter recording. At 1 month, the IM revealed mode switching episodes in 12 patients, 6 of whom had used the weak criterion. No inappropriate mode switching episodes was recorded during exercise testing at the 1-month follow-up. These results confirm the reliability and efficiency of this algorithm as well as the requirement for a specific algorithm to compensate for transient loss of sensing during AA.
authors.affiliation: CHU, Bordeaux, France.
authors.forename: L
authors.initials: L
authors.lastname: Gencel
authors.forename: L
authors.initials: L
authors.lastname: Geroux
authors.forename: J
authors.initials: J
authors.lastname: Clementy
authors.forename: D
authors.initials: D
authors.lastname: Shah
authors.forename: S
authors.initials: S
authors.lastname: Cazeau
authors.forename: N
authors.initials: N
authors.lastname: Saoudi
authors.forename: G
authors.initials: G
authors.lastname: Pioger
authors.forename: T
authors.initials: T
authors.lastname: Lavergne
mesh_terms: D000465:Algorithms; D001145:Arrhythmias, Cardiac / Q000503:physiopathology / Q000517:prevention & control*; D016275:Atrial Function; D002304:Cardiac Pacing, Artificial / Q000379:methods* / Q000706:statistics & numerical data; D002312:Cardiomyopathy, Hypertrophic / Q000503:physiopathology; D015716:Electrocardiography, Ambulatory; D004867:Equipment Design; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006327:Heart Block / Q000503:physiopathology; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D015203:Reproducibility of Results; D012804:Sick Sinus Syndrome / Q000503:physiopathology; D012849:Sinoatrial Node / Q000502:physiology; D016276:Ventricular Function