Progression of selective IgA deficiency to common variable immunodeficiency in a 16 year old boy.
A case report of a 16 year old boy in whom selective IgA deficiency progressed to typical common variable immunodeficiency (CVID) is described. This boy with a history of frequent but not severe respiratory tract infections was referred to hospital because of severe pleuropneumonia and decreased levels of IgA (0.23 g/L), but normal IgG and IgM levels. Lymphocyte subpopulation determination revealed a decreased proportion of CD4+ lymphocytes (30%) and an increased proportion of CD8+ lymphocytes (32%), while CD3+, CD19+ and CD16+/56+ subpopulations were normal. During the subsequent 17 months a gradual decrease in IgG (ultimate level 2.23 g/L), IgA (< 0.05 g/L) and IgM (< 0.05 g/L) levels was observed, the decrease in IgM being the slowest reflecting a constant heavy chain gene order on chromosome 14. The observation supports the thesis of a close relation of selective IgA deficiency and common variable immunodeficiency.
Litzman
J
J
Dept. Clin. Immunology, Masaryk University, Faculty Hospital, Brno, Czech.
Burianova
M
M
Thon
V
V
Lokaj
J
J
D000293:Adolescent; D017074:Common Variable Immunodeficiency / Q000097:blood / Q000276:immunology* / Q000628:therapy; D018450:Disease Progression; D006801:Humans; D017098:IgA Deficiency / Q000097:blood / Q000150:complications / Q000276:immunology*; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D008297:Male; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000209:etiology
D007074:Immunoglobulin G; D007075:Immunoglobulin M