Crohn's disease and acute leukocytoclastic vasculitis of skin.
A 39-yr-old white male with a prolonged history of Crohn's disease presented with worsening diarrhea associated with an increasingly painful rash of both lower extremities as well as left ankle swelling. A skin biopsy revealed an acute leukocytoclastic vasculitis. Intravenous hydrocortisone followed by oral prednisone achieved a rapid remission of the both cutaneous and gastrointestinal manifestations. Long-term remission has been maintained with 6-mercaptopurine and mesalamine. The rare association between cutaneous vasculitis and Crohn's disease is discussed and earlier reported cases reviewed.
Zlatanic
J
J
Lenox Hill Hospital, Section of Gastroenterology, New York University School of Medicine, New York, USA.
Fleisher
M
M
Sasson
M
M
Kim
P
P
Korelitz
B I
BI
D000328:Adult; D000636:Aminosalicylic Acids / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001808:Blood Vessels / Q000473:pathology; D003424:Crohn Disease / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D008297:Male; D015122:Mercaptopurine / Q000627:therapeutic use; D019804:Mesalamine; D011241:Prednisone / Q000627:therapeutic use; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
D000636:Aminosalicylic Acids; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine; D015122:Mercaptopurine; D011241:Prednisone; D006854:Hydrocortisone