Local changes in oxygen tension and blood flow in the brain under hyperthermia induced by intracerebroventricular NMDA in rats.
Intracerebroventricular administration of N-methyl-D-aspartate (NMDA; 100 nmol) to rats increased oxygen tension and blood flow of the caudate putamen and the ventral hippocampus. The regional differences in the increase in oxygen tension could not be explained in terms of those in the blood flow. NMDA also increased the temperature of the two brain regions to a similar extent, and these increases preceded that in the rectum. These findings suggest that NMDA receptor stimulation leads to exposure of the brain to a higher oxygen level and higher temperature, which might be involved in NMDA neurotoxicity.
Hara
S
S
Department of Forensic Medicine, Tokyo Medical College, Japan.
Mukai
T
T
Kuriiwa
F
F
Iwata
N
N
Kano
S
S
Endo
T
T
D000818:Animals; D001831:Body Temperature; D001921:Brain / Q000098:blood supply*; D002421:Caudate Nucleus / Q000098:blood supply / Q000378:metabolism / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology*; D005334:Fever / Q000503:physiopathology*; D006624:Hippocampus / Q000098:blood supply / Q000378:metabolism / Q000503:physiopathology; D007276:Injections, Intraventricular; D008297:Male; D016202:N-Methylaspartate / Q000494:pharmacology*; D010100:Oxygen / Q000378:metabolism*; D011699:Putamen / Q000098:blood supply / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012212:Rheology
D018690:Excitatory Amino Acid Agonists; D016202:N-Methylaspartate; D010100:Oxygen