title: Clinical evaluation of serum amlodipine level in patients with angina pectoris.
abstract: Serum amlodipine levels were determined in 18 patients with vasospastic angina. Patients were divided into two groups: Group A (n = 9) received amlodipine 5 mg by single daily administration, and Group B (n = 9) received 10 mg given by single daily administration for the first 3 days, then 5 mg from the 4th day on. The serum amlodipine concentration in Group A took 7 days to reach a steady state of around 8 ng/ml. The level in Group B was 8.9 ng/ml at 3 days. From these results, the optimal dosage of amlodipine in the treatment of angina pectoris is 10 mg for the initial 3 days followed by 5 mg thereafter.
authors.affiliation: Division of Cardiology, Tsubame Rosai Hospital, Niigata, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Ochiai
authors.forename: T
authors.initials: T
authors.lastname: Washizuka
authors.forename: T
authors.initials: T
authors.lastname: Inomata
authors.forename: Y
authors.initials: Y
authors.lastname: Miyakita
authors.forename: M
authors.initials: M
authors.lastname: Shiba
authors.forename: T
authors.initials: T
authors.lastname: Izumi
authors.forename: A
authors.initials: A
authors.lastname: Shibata
authors.forename: Y L
authors.initials: YL
authors.lastname: Qu
authors.forename: T
authors.initials: T
authors.lastname: Nagatomo
mesh_terms: D000368:Aged; D017311:Amlodipine / Q000097:blood* / Q000493:pharmacokinetics / Q000494:pharmacology; D000787:Angina Pectoris / Q000188:drug therapy / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000097:blood* / Q000494:pharmacology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D002121:Calcium Channel Blockers; D017311:Amlodipine