A preliminary study of the neuropsychological heterogeneity of familial schizophrenia.
This exploratory study describes the heterogeneity of the neuropsychological deficits that characterize familial schizophrenia. Forty-six familial schizophrenics showed significantly more variability in abstraction and problem-solving and motor control than 39 non-familial schizophrenics. Cluster analyses of these two neuropsychological parameters indicate that while the non-familial schizophrenics fall into one homogeneous cluster, the familial schizophrenics fall into three relatively distinct clusters which differ significantly in their morbid risk for schizophrenic-spectrum disorder. These preliminary data suggest that frontal lobe deficits are associated with an increased familial risk for schizophrenia.
Sautter
F J
FJ
Tulane University Medical School, Department of Psychiatry and Neurology, New Orleans, LA 70112, USA.
McDermott
B E
BE
Cornwell
J
J
Johnson
J
J
Borges
A
A
Wilson
A F
AF
Vasterling
J J
JJ
Foundas
A L
AL
D000293:Adolescent; D000328:Adult; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008297:Male; D019965:Neurocognitive Disorders / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology / Q000523:psychology; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010641:Phenotype; D012016:Reference Values; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D012565:Schizophrenic Psychology