title: Factors influencing the distribution of metastases and survival in metastatic breast carcinoma.
abstract: A total of 370 patients with metastatic breast, carcinoma who had been followed at Hacettepe Oncology Department between 1980 and 1991 were retrospectively analyzed for the factors influencing the distribution of metastases and survival. Median age was 47 years. Radical or modified radical mastectomies were performed in 199 (53.8%). Infiltrative ductal carcinoma was the most common pathologic subtype (69.4%). In 191 patients who were evaluated for estrogen receptor (ER) status, 101 (52.9%) were positive and 90 (47.1%) were negative. The distribution of first metastases did not differ between the soft tissue, bone, and visceral sites. The second, third, and fourth metastases were more common in visceral sites (p < 0.05). ER and menopausal status did not affect distribution. Mortality rate was significantly lower in the group having the first metastasis to the bone (p < 0.05). Of interest, first metastases were predominantly found in visceral sites in patients having radical or modified radical mastectomies (p < 0.05). Response to therapy, presence of initial metastases, axillary status, and age were the important factors influencing the overall survival in univariate analysis, whereas response to therapy, ER status, age, and presence of initial metastases were the important factors according to the multivariate analysis.
authors.affiliation: Department of Medical Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Barişta
authors.forename: E
authors.initials: E
authors.lastname: Baltali
authors.forename: I H
authors.initials: IH
authors.lastname: Güllü
authors.forename: N
authors.initials: N
authors.lastname: Güler
authors.forename: I
authors.initials: I
authors.lastname: Celik
authors.forename: O
authors.initials: O
authors.lastname: Saraçbaşi
authors.forename: G
authors.initials: G
authors.lastname: Tekuzman
authors.forename: A
authors.initials: A
authors.lastname: Kars
authors.forename: Y
authors.initials: Y
authors.lastname: Ozişik
authors.forename: S
authors.initials: S
authors.lastname: Ruacan
authors.forename: I L
authors.initials: IL
authors.lastname: Atahan
authors.forename: D
authors.initials: D
authors.lastname: Firat
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001859:Bone Neoplasms / Q000556:secondary; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D015411:Mastectomy, Modified Radical; D015409:Mastectomy, Radical; D008593:Menopause; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis; D012189:Retrospective Studies; D012307:Risk Factors; D012983:Soft Tissue Neoplasms / Q000556:secondary; D015996:Survival Rate; D016896:Treatment Outcome; D014421:Turkey / Q000453:epidemiology; D014781:Viscera
chemical_list: D011960:Receptors, Estrogen