[Immunizing and immunomodulating activity of wild measles virus at the focus of measles infection].
The effect of a wild measles virus circulating in a childhood collective body on the immune status of 80 children has been studied over time. Only using enzyme immunoassay was it possible to fully record and assess the degree of booster effect of the virus on children in case of infection transmission. In 25% cases the increment of antibodies was at the expense of specific IgM antibodies appearing in the sera of children. By the end of the first month 60% of children developed a relative measles immunodepression. Analysis of the index of cell stimulation with phytohemagglutinin in the presence of suppressors enabled us to single out a group of children (30%) with weakly expressed suppressive factor. The observed phenomenon with a high degree of reliability may be used as an index of immune response development.
Iuminova
N V
NV
Krasnova
V P
VP
Lezhneva
L N
LN
D002648:Child; D006801:Humans; D007124:Immunoenzyme Techniques; D007075:Immunoglobulin M / Q000097:blood; D008457:Measles / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D008459:Measles virus / Q000276:immunology* / Q000302:isolation & purification; D009031:Moscow / Q000453:epidemiology; D009093:Mucus / Q000821:virology; D009297:Nasal Mucosa / Q000378:metabolism; D014766:Viremia
D007075:Immunoglobulin M