Autoantibody reactivity in serum of patients with Alzheimer's disease and other age-related dementias.
Serum antibodies against a series of antigens, including an organ-specific central nervous system (CNS) antigen and the neurotransmitter serotonin, were investigated in 22 patients with Alzheimer's Disease (n=15) and other age-related dementias (n=7) by indirect immunofluorescence assay and enzyme-linked immunosorbent assay. Patients with dementia showed an increase of antibody-positive sera against nuclear antigen, gastric parietal cells, CNS antigen, gangliosides (Gm1), laminin, and keratin. Alzheimer's Disease patients alone exhibited antibodies against CNS antigen. However, the results do not show sufficient specificity and sensitivity for use as a diagnostic indicator.
Schott
K
K
Psychiatrische Universitatsklinik, Tubingen, Germany.
Wormstall
H
H
Dietrich
M
M
Klein
R
R
Batra
A
A
D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology*; D015161:Dementia, Multi-Infarct / Q000097:blood* / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D005677:G(M1) Ganglioside / Q000097:blood* / Q000276:immunology*; D049690:History, Ancient; D006801:Humans; D007633:Keratins / Q000097:blood* / Q000276:immunology*; D007797:Laminin / Q000097:blood* / Q000276:immunology*; D008297:Male; D012701:Serotonin / Q000097:blood* / Q000276:immunology*
D001323:Autoantibodies; D007797:Laminin; D012701:Serotonin; D005677:G(M1) Ganglioside; D007633:Keratins