Tumor detachments of the retinal pigment epithelium in ocular/ central nervous system lymphoma.
BACKGROUND
Ocular/central nervous system (CNS) lymphoma is a B-lymphocyte-derived tumor that characteristically involves the retina, optic nerve head, vitreous, and subretinal pigment epithelial areas of the eye.


METHODS
A retrospective analysis of clinical history and photography fluorescein angiography, histopathology, and immunocytochemistry of an untreated patient with ocular/CNS lymphoma was performed.


RESULTS
Tumor detachments of the retinal pigment epithelium (RPE) evolved into areas of RPE atrophy and depigmentation and disciform scars. Histopathologic studies disclosed foci of tumor cells in the wall of and around blood vessels and between the RPE and Bruch's membrane. Immunocytochemistry identified the malignant cells as B-lymphocytes.


CONCLUSIONS
The clinicopathologic features of a patient with ocular/CNS B-cell lymphoma are presented. Retinal pigment epithelium tumor detachments evolved to areas of RPE atrophy and depigmentation and disciform scars.
Dean
J M
JM
Eye Pathology Laboratory, Wilmer Institute and Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Novak
M A
MA
Chan
C C
CC
Green
W R
WR
D000368:Aged; D001284:Atrophy; D001932:Brain Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D005134:Eye Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D005451:Fluorescein Angiography; D006801:Humans; D007150:Immunohistochemistry; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D010857:Pigment Epithelium of Eye / Q000473:pathology; D010858:Pigmentation; D012163:Retinal Detachment / Q000209:etiology* / Q000473:pathology; D012189:Retrospective Studies