The mouse X-linked developmental mutant, tattered, lies between DXMit55 and Xkh and is associated with hyperkeratinization.
The X-linked mouse mutant phenotype, tattered (Td), is associated with prenatal lethality of males and has been mapped previously to the proximal region of the mouse X chromosome. We report here a refined position for Td and demonstrate that it lies in the approximately 0.9-cM interval between DXMit55 and Xkh. This enables us to predict that the human homologue lies either between CLCN5 and the evolutionary breakpoint that lies between GATA1 and PFC or distal to XK and proximal to the evolutionary breakpoint that lies between XK and DMD. Histological analysis of dorsal skin taken from 5-day-old heterozygous animals revealed that the mutation was associated with patches of hyperkeratinzation in the epidermis and in the hair follicles, accompanied by a mild inflammatory infiltrate in the underlying dermis.
Uwechue
I C
IC
MRC Mammalian Genetics Unit, Harwell, Oxon, United Kingdom.
Cooper
B F
BF
Goble
C
C
Hacker
T
T
Blair
H J
HJ
Burke
D T
DT
Herman
G
G
Boyd
Y
Y
D000818:Animals; D002874:Chromosome Mapping; D005314:Embryonic and Fetal Development / Q000235:genetics; D005260:Female; D005313:Fetal Death / Q000235:genetics; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D007633:Keratins / Q000378:metabolism*; D008297:Male; D051379:Mice; D009154:Mutation; D014960:X Chromosome
D005819:Genetic Markers; D007633:Keratins