Molecular characterization of a nonneuronal human UNC18 homolog.
A cDNA clone encoding a human homolog of the Caenorhabditis elegans unc-18 gene was identified following random sequencing of clones from IL-2-activated human NK cells. This cDNA clone is related to the nonneuronal Munc-18b and so has been called Hunc-18b. The Hunc-18b transcripts were found in most human tissues, with the exception of brain and skeletal muscle, and in cells from all lymphoid lineages. The Hunc-18b gene was localized to human chromosome 19p13.2-p13.3, and the mouse homolog, Munc-18b, was mapped to the proximal region of mouse Chromosome 8.
Ziegler
S F
SF
Darwin Molecular Corporation, Bothell, Washington 98021, USA. ziegler@darwin.com
Mortrud
M T
MT
Swartz
A R
AR
Baker
E
E
Sutherland
G R
GR
Burmeister
M
M
Mulligan
J T
JT
D000595:Amino Acid Sequence; D000818:Animals; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D003001:Cloning, Molecular; D018076:DNA, Complementary; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D008969:Molecular Sequence Data; D051938:Munc18 Proteins; D009419:Nerve Tissue Proteins / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D033921:Vesicular Transport Proteins
D018076:DNA, Complementary; D051938:Munc18 Proteins; D009419:Nerve Tissue Proteins; C497941:Stxbp2 protein, mouse; D033921:Vesicular Transport Proteins