Associations between Porphyromonas gingivalis and oral treponemes in subgingival plaque.
Colonization and/or proliferation of Treponema denticola may depend on the presence of Porphyromonas gingivalis. The aims of this study were to confirm this synergistic relationship, to determine whether other oral bacteria were similarly associated with P. gingivalis and to relate coinfection to the periodontal status of plaque donors. Subgingival plaque was collected from every tooth except third molars in 106 subjects who were grouped by their worst periodontal condition. In addition to P. gingivalis, monoclonal antibodies were used to identify Campylobacter rectus, Eikenella corrodens, T. denticola, Treponema socranskii and pathogen-related oral spirochetes. Associations of these bacteria with coinfection by P. gingivalis were assessed by estimated odds ratios. The results indicate that coinfection with P. gingivalis is linked to all tested bacteria, but each pair was associated with distinct periodontal conditions. The distribution of coinfected sites suggests biased colonization of facial surfaces over lingual surfaces.
Riviere
G R
GR
Department of Pediatric Dentistry, School of Dentistry, Oregon Health Sciences University, Portland 97201-3097, USA.
Smith
K S
KS
Carranza
N
N
Tzagaroulaki
E
E
Kay
S L
SL
Dock
M
M
Zhu
X
X
DeRouen
T A
TA
D000328:Adult; D001424:Bacterial Infections / Q000382:microbiology; D002167:Campylobacter / Q000302:isolation & purification; D003773:Dental Plaque / Q000382:microbiology*; D017753:Ecosystem; D016124:Eikenella corrodens / Q000302:isolation & purification; D005260:Female; D005891:Gingivitis / Q000382:microbiology / Q000473:pathology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010512:Periodontal Index; D010518:Periodontitis / Q000382:microbiology* / Q000473:pathology; D016966:Porphyromonas gingivalis / Q000302:isolation & purification* / Q000502:physiology; D015163:Superinfection; D014208:Treponema / Q000302:isolation & purification* / Q000502:physiology