title: Renal replacement therapy in the elderly.
abstract: METHODS
  In a retrospective study the medical records of 122 patients aged over 65 years at the start of renal replacement therapy (RRT) in our dialysis centre were analysed.
  
  
  RESULTS
  The mean age at the start of RRT was 72.7 +/- 5.7 years (range 65.0-90.3). Seventy-six percent were treated with haemodialysis, 21% with haemofiltration and 3% with continuous ambulatory peritoneal dialysis. There was no significant difference in survival between the different modes of treatment. The median survival was 23.8 months, the actuarial survival rates at 2, 5 and 7 years were 50, 27 and 18%, respectively. Patients aged between 65 and 75 years had a median survival of 36.4 months, patients above 75 years of 12.5 months (P = 0.009). Patients with tubulo-interstitial nephritis had a significantly longer survival than patients with other renal diseases. When chronic obstructive pulmonary disease or peripheral vascular disease was present, there was a significantly shorter survival. There was no difference in survival between patients with malignancy, cardiac diseases, diabetes mellitus or cerebrovascular diseases before the start of RRT and others. After the start of RRT there was a significant increase of infectious and psychiatric disease. During the study period 70% died, most frequently from cardiovascular causes (28%), discontinuation of dialysis treatment (28%) or infection (19%).
  
  
  CONCLUSIONS
  We think that both survival and quality of life in elderly patients during RRT are acceptable, and that neither age nor comorbidity should be a contraindication to RRT.
authors.affiliation: Department of Medicine, St. Joseph Hospital, Veldhoven, Netherlands.
authors.forename: C M
authors.initials: CM
authors.lastname: Mandigers
authors.forename: W
authors.initials: W
authors.lastname: de Jong
authors.forename: A W
authors.initials: AW
authors.lastname: van den Wall Bake
authors.forename: P G
authors.initials: PG
authors.lastname: Gerlag
mesh_terms: D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D011788:Quality of Life; D017582:Renal Replacement Therapy / Q000379:methods; D012189:Retrospective Studies; D015996:Survival Rate