title: Acute urticaria caused by subcutaneous recombinant hirudin: evidence for an IgG-mediated hypersensitivity reaction.
authors.affiliation: Department of Dermatology, Kantonsspital, Basle, Switzerland.
authors.forename: A J
authors.initials: AJ
authors.lastname: Bircher
authors.forename: C H
authors.initials: CH
authors.lastname: Czendlik
authors.forename: S L
authors.initials: SL
authors.lastname: Messmer
authors.forename: P
authors.initials: P
authors.lastname: Müller
authors.forename: H
authors.initials: H
authors.lastname: Howald
mesh_terms: D000208:Acute Disease; D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced*; D053818:Chymases; D003875:Drug Eruptions / Q000209:etiology*; D006629:Hirudins / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000276:immunology; D006801:Humans; D007114:Immunization; D007074:Immunoglobulin G / Q000276:immunology*; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007428:Intradermal Tests; D008297:Male; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D012697:Serine Endopeptidases / Q000097:blood; D012882:Skin Tests; D053802:Tryptases; D014581:Urticaria / Q000139:chemically induced*
chemical_list: D006629:Hirudins; D007074:Immunoglobulin G; D011994:Recombinant Proteins; D012697:Serine Endopeptidases; C083294:chymase 2; D053818:Chymases; D053802:Tryptases; C060225:desirudin