Risch's lambda values for human obesity.
OBJECTIVE
Risch's lambda statistic (lambda R) is related to the heritability of traits and can be useful in several contexts, including the conduct of power analyses to determine sample size for gene mapping studies. However, values of lambda R have not been presented for human obesity.


RESULTS
Using both analytic and empirical approaches, the present study calculates estimates of lambda R. Examples are provided to illustrate the use of these estimates for determining sample size for genetic mapping studies.
Allison
D B
DB
Obesity Research Center, St. Luke's/Roosevelt Hospital, Columbia University College of Physicians & Surgeons, NY, NY, USA.
Faith
M S
MS
Nathan
J S
JS
D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002874:Chromosome Mapping; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D009749:Nutrition Surveys; D009765:Obesity / Q000453:epidemiology* / Q000235:genetics*; D013223:Statistics as Topic / Q000379:methods*; D018433:Twin Studies as Topic