title: Intracellular signalling: the mad way to do it.
abstract: A family of proteins has been identified that transduce a signal inside cells following binding of a TGF-beta family ligand to its cognate receptor. Like the prototype Drosophila protein Mad, many members of the family play key roles in developmental signalling.
authors.affiliation: Department of Growth and Development, University of California at San Francisco 94143-0640, USA.
authors.forename: R
authors.initials: R
authors.lastname: Derynck
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D017173:Caenorhabditis elegans / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology*; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000502:physiology; D016147:Genes, Tumor Suppressor; D006801:Humans; D012097:Repressor Proteins; D015290:Second Messenger Systems / Q000502:physiology*; D014157:Transcription Factors; D016212:Transforming Growth Factor beta / Q000502:physiology
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; C112506:MAD protein, Drosophila; C079439:MXD1 protein, human; D012097:Repressor Proteins; D014157:Transcription Factors; D016212:Transforming Growth Factor beta