The role of pulsatility in end-organ microcirculation after cardiogenic shock.
To estimate the effectiveness of pulsatility in end-organ microcirculation after cardiogenic shock, experimental studies using swine were done. Cardiogenic shock was produced in 14 pigs by ligating the left anterior descending branches so that mean aortic pressure dropped to 60% of the control value. After inducing shock, left atrial to ascending Ao bypass was initiated. A pneumatic pulsatile pump (Zeon Medical Inc, Tokyo, Japan) was used in seven pigs (Group P) and a centrifugal pump (BP-80, BioMedicus Inc, Minneapolis, MN) in seven (Group NP). In both groups, about half the usual cardiac output was supported for 3 hr, maintaining mean aortic pressure at approximately 100 mm Hg. The pulse pressure was 36.6 +/- 4.6 mm Hg in Group P, and 14.3 +/- 1.5 mm Hg in Group NP. Epicardial and endocardial regional flows recovered after assist in both groups. There were no significant differences between the two groups. However, liver tissue flow, renal cortex flow, and stomach mucous flow in Group P was significantly higher than those of Group NP after support (p < 0.05). In addition, arterial blood ketone ratio in Group P was 0.61 +/- 0.13 vs 0.39 +/- 0.06 in Group NP, a significant difference (p < 0.05). These results suggest that in uneven blood flow distribution of end organs after cardiogenic shock, pulsatility was effective in improving and maintaining function and microcirculation of end organs, preventing multiorgan failure.
Orime
Y
Y
Second Department of Surgery, Nihon University School of Medicine Tokyo, Japan.
Shiono
M
M
Nakata
K
K
Hata
M
M
Sezai
A
A
Yamada
H
H
Iida
M
M
Kashiwazaki
S
S
Nemoto
M
M
Kinoshita
J
J
Kojima
T
T
Saito
T
T
Sezai
Y
Y
D000818:Animals; D005069:Evaluation Studies as Topic; D006353:Heart-Assist Devices; D006439:Hemodynamics; D007657:Ketone Bodies / Q000097:blood; D019344:Lactic Acid / Q000378:metabolism; D008833:Microcirculation / Q000503:physiopathology; D011673:Pulsatile Flow; D019289:Pyruvic Acid / Q000378:metabolism; D012039:Regional Blood Flow; D012770:Shock, Cardiogenic / Q000503:physiopathology* / Q000628:therapy*; D013552:Swine
D007657:Ketone Bodies; D019344:Lactic Acid; D019289:Pyruvic Acid