title: Neonatal systemic candidiasis.
abstract: Systemic candidiasis is notoriously difficult to diagnose in neonates; however, it is frequently described and has a high mortality and morbidity. It is particularly likely to occur in extremely low birthweight babies, especially those receiving long-term parenteral nutrition and antibiotics. The clinical features are non-specific. Thrombocytopenia occurs in almost all cases of systemic candidiasis, but also in about half the cases of bacterial sepsis. Empirical antifungal therapy should be considered more readily for high-risk, clinically septic, thrombocytopenic babies.
authors.affiliation: Department of Perinatal Medicine, King George V Hospital for Mothers and Babies, Camperdown, New South Wales, Australia.
authors.forename: M
authors.initials: M
authors.lastname: McDonnell
authors.forename: D
authors.initials: D
authors.lastname: Isaacs
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D002177:Candidiasis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000401:mortality; D002405:Catheterization, Central Venous / Q000009:adverse effects; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000401:mortality; D012307:Risk Factors; D013921:Thrombocytopenia / Q000209:etiology
chemical_list: D000935:Antifungal Agents