Genetic studies of a new mutant strain showing shivering in the mouse.
A new mutant with shivering, Hula dance Sendai (tentatively named hus gene), was found in the IVCE strain. A congenic strain, C57BL/6JJcl-hus, was established by the cross-intercross method using IVCE-hus as the donor strain and C57BL/6JJcl as the recipient. No significant differences were observed in the age of the onset of shivering and life span between B6-hus and IVCE-hus mice. Genetic analyses demonstrated that this mutation is governed by an autosomal recessive gene (Mbphus) and is an allele of the Mbpshi gene (Chr. 18).
Guo
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X
Institute for Experimental Animals, Tohoku University School of Medicine, Miyagi-ken, Japan.
Nobunaga
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T
Katoh
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H
D000375:Aging; D000483:Alleles; D000818:Animals; D001947:Breeding; D003433:Crosses, Genetic; D008017:Life Expectancy; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008818:Mice, Neurologic Mutants / Q000235:genetics*; D004676:Myelin Basic Protein / Q000172:deficiency / Q000235:genetics*; D012768:Shivering / Q000235:genetics*
D004676:Myelin Basic Protein