title: Plasma membrane and sarcoplasmic reticulum Ca-ATPase and smooth muscle.
abstract: Calcium ions (Ca2+) are involved in the regulation of many cellular activities. The Ca-ATPase(s) of the plasma membrane and of the endoplasmic reticulum play an important role in controlling the intracellular Ca2+ concentration. Therefore, it is not unexpected that these enzymes are modulated by different factors. The activity of the plasma membrane Ca-ATPase is modified by the amount of negatively charged phospholipids surrounding the enzyme. The regulation of the endoplasmic reticulum Ca-ATPase depends on the phosphorylation of phospholamban by cAMP- and cGMP-dependent protein kinase. These two different Ca2+ transport ATPases are present in both visceral and vascular smooth muscle, but tissue- and species-dependent differences in their relative amount have been observed. In this article we will review the characteristics of Ca-ATPases of the smooth muscle.
authors.affiliation: Department of Medicine, Baylor College of Medicine, Houston, Tex 77030, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Gonzalez
authors.forename: L J
authors.initials: LJ
authors.lastname: Jost
authors.forename: D
authors.initials: D
authors.lastname: Rouse
authors.forename: W N
authors.initials: WN
authors.lastname: Suki
mesh_terms: D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000502:physiology*; D002462:Cell Membrane / Q000201:enzymology*; D009131:Muscle, Smooth, Vascular / Q000201:enzymology*; D012519:Sarcoplasmic Reticulum / Q000201:enzymology*
chemical_list: D000252:Calcium-Transporting ATPases; D002118:Calcium