Histopathological reaction of calcium phosphate cement in periodontal bone defect.
In this study, we evaluated the osteoconductivity of calcium phosphate cement (CPC) as compared to that of a current hydroxyapatite-based material (AP) by implanting the materials in surgically formed defects in the jaws of dogs. One month post-operation, slight inflammatory reactions were observed in tissue areas adjacent to either CPC mass or AP. Three months after operation, the CPC mass-filled defects were covered with periosteum and bone tissues. The CPC mass in the defects was partially replaced by newly formed bone. In bone defects filled with AP, most of the interparticle space was filled with connective tissues including bone tissues. Six months post-operation, the CPC mass-filled defects were covered with periosteum and new bone, and most of the CPC mass was replaced by bone. Interparticle spaces of AP were filled with connective tissues and bone tissues.
Fujikawa
K
K
Department of Periodontology, Nihon University School of Dentistry, Japan.
Sugawara
A
A
Murai
S
S
Nishiyama
M
M
Takagi
S
S
Chow
L C
LC
D016301:Alveolar Bone Loss / Q000601:surgery*; D000539:Alveolar Process / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D002130:Calcium Phosphates / Q000494:pharmacology*; D003238:Connective Tissue / Q000187:drug effects / Q000254:growth & development; D003738:Dental Cements / Q000494:pharmacology*; D004285:Dogs; D017886:Durapatite / Q000494:pharmacology; D019736:Prostheses and Implants; D013524:Surgical Flaps
D002130:Calcium Phosphates; D003738:Dental Cements; D017886:Durapatite