[Human immunodeficiency virus infection: physiopathological approach to specific therapeutic strategies].
Our understanding of the physiopathology of HIV infection has considerably improved: the determination of HIV viral load, the impact of new antiretroviral agents (the protease inhibitors) and the discovery of various patterns of immune response (type T-helperl - T-helper2; Th1/Th2) have contributed to a comprehensive view of HIV infection from the seroconversion to the latest stage of AIDS. This new understanding allows to set up new therapeutical goals such as the rapid reduction of viral load during seroconversion or the reconstitution of Th1 pattern during clinical latency. This global individualised therapeutical strategy is now feasible. HIV infection has become a chronic disease which is presently treatable.
Clumeck
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Centre de Référence SIDA - ULB, Service des Maladies Infectienses, C.H.U. Saint-Pierre, Bruxelles.
D018791:CD4 Lymphocyte Count; D016516:CD4-CD8 Ratio; D016572:Cyclosporine / Q000627:therapeutic use; D006678:HIV / Q000187:drug effects; D015658:HIV Infections / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007376:Interleukin-2 / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000627:therapeutic use; D014779:Virus Replication / Q000187:drug effects
D007166:Immunosuppressive Agents; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D016572:Cyclosporine