Hormonal responses to d- and d,l-fenfluramine in healthy human subjects.
Two different doses of d-fenfluramine HCl and d,l-fenfluramine HCl (0.5 mg/kg and 1.0 mg/kg) were administered to 11 healthy male volunteers to compare the neuroendocrine responses to these two forms of fenfluramine in human subjects. Prolactin (PRL) responses to d- and d,l-fenfluramine were significantly greater than those to placebo and were equivalent at both dose levels. Adrenocortiatrophic-releasing hormone (ACTH) and cortisol (CORT) responses to d-fenfluramine at both dose levels were also significantly greater than those to placebo. In contrast, the higher dose of d,l-fenfluramine was associated only with a significant CORT response in comparison to placebo. PRL responses to d-fenfluramine were higher than the PRL response to d,l-fenfluramine at either dose level. The PRL response to d-fenfluramine at 0.5 mg/kg was very highly correlated with the PRL responses to d,l-fenfluramine at 1.0 mg/kg (r = 0.97, n = 10). Homovanillic acid (HVA) were not altered by either d, or d,l-fenfluramine at either dose in a subsample of subjects (n = 4). ACTH/CORT responses to d- and d,l-fenfluramine were modestly intercorrelated. These data suggest that the PRL response evoked by d-fenfluramine is quantitatively very similar to that evoked by d,l-fenfluramine.
Coccaro
E F
EF
Department of Psychiatry, Medical College of Pennsylvania, Philadelphia, USA.
Kavoussi
R J
RJ
Cooper
T B
TB
Hauger
R L
RL
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D000704:Analysis of Variance; D005277:Fenfluramine / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D006719:Homovanillic Acid / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D011388:Prolactin / Q000097:blood*; D012016:Reference Values; D018490:Serotonin Agents / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology; D013997:Time Factors
D000324:Adrenocorticotropic Hormone; D005277:Fenfluramine; D006719:Homovanillic Acid; D006854:Hydrocortisone; D011388:Prolactin; D018490:Serotonin Agents; D017367:Selective Serotonin Reuptake Inhibitors