title: Perioperative myocardial infarction in coronary artery disease patients and 'at-risk' for coronary artery disease patients undergoing non-cardiac surgery.
abstract: BACKGROUND
  Perioperative myocardial infarction (POMI) carries a high mortality and occurs more commonly in patients with a history of coronary artery disease (CAD). However, there are also other patients undergoing surgery who are 'at risk' for CAD but who do not have a history of infarction or angina. We compared the incidence of POMI in these two groups.
  
  
  METHODS
  In a prospective study of 69 men and 39 women over 30 years of age undergoing non-cardiac surgery under general or regional anaesthesia, 56 had definite CAD and 52 were 'at-risk' for CAD. All these patients were followed up with serial postoperative electrocardiography and CK-MB isoenzyme analysis for the diagnosis of POMI.
  
  
  RESULTS
  The POMI rate was 32% in definite CAD patients and 15% in patients 'at-risk' for CAD. Mortality in patients with POMI was 17% in those with CAD and 13% in those 'at-risk' for CAD. Perioperative myocardial infarction was maximal in the first 24 hours following surgery (77%). All the POMIs were painless. Anaesthesia techniques--whether regional or general--did not influence the incidence of POMI (Chi-square, p > 0.05). The type of drugs used in the treatment of CAD such as beta-blockers, calcium channel blockers and antiplatelet agents did not cause any difference in the incidence of POMI (Chi-square, p > 0.05). Patients who had either an intraoperative hypertensive episode, tachycardia, arrhythmias or ST-segment changes had a higher incidence of POMI (Chi-square, p > 0.05). The incidence of POMI was not lower in patients undergoing transurethral resection of the prostate compared to patients undergoing other types of non-cardiac surgery (Chi-square, p > 0.05).
  
  
  CONCLUSIONS
  POMI occurs in one-third of patients with a history of CAD and one-sixth of those 'at-risk'. It carries a mortality of 17% and 13% respectively. Decisions to operate on such patients should be taken with caution.
authors.affiliation: Department of Anaesthesia, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: M K
authors.initials: MK
authors.lastname: Varma
authors.forename: G D
authors.initials: GD
authors.lastname: Puri
authors.forename: P
authors.initials: P
authors.lastname: Chari
authors.forename: J S
authors.initials: JS
authors.lastname: Verma
authors.forename: K K
authors.initials: KK
authors.lastname: Kohli
mesh_terms: D000368:Aged; D003327:Coronary Disease / Q000150:complications*; D005260:Female; D006801:Humans; D007431:Intraoperative Complications; D008297:Male; D009203:Myocardial Infarction / Q000150:complications*; D011183:Postoperative Complications; D011446:Prospective Studies; D013514:Surgical Procedures, Operative