title: Arterial input functions from MR phase imaging.
abstract: A method is presented for obtaining high-sensitivity arterial input functions following bolus intravenous contrast agent administration. Arterial contrast agent is monitored by phase reconstruction of single-shot echo-planar images. During bolus injections of a gadolinium (Gd) agent in a baboon, data were acquired at the mid-abdominal aorta, and magnitude and phase-shift images were reconstructed. Pairwise image subtraction was used to minimize phase aliasing. The phase-based method is shown to have a significant potential improvement in sensitivity compared to the magnitude approach. The phase method also has a general linear response to concentration. This method may have potential utility in quantitative imaging of blood flow and contrast agent kinetics.
authors.affiliation: Mallinckrodt Institute of Radiology Neuroimaging Laboratory, Washington University School of Medicine, Saint Louis, Missouri 63110, USA.
authors.forename: E
authors.initials: E
authors.lastname: Akbudak
authors.forename: T E
authors.initials: TE
authors.lastname: Conturo
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000502:physiology*; D001783:Blood Flow Velocity; D005260:Female; D007262:Infusions, Intravenous; D018810:Magnetic Resonance Angiography; D010215:Papio; D004369:Pentetic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives; D012680:Sensitivity and Specificity
chemical_list: C073849:DTPA bis(methoxyethylamide); D004369:Pentetic Acid