title: Serum uric acid, insulin secretion and resistance in nonhyperuricemic and hyperuricemic obese female subjects.
abstract: In order to study the relationships between obesity, serum uric acid, insulin secretion and insulin resistance in female subjects, we evaluated serum C-peptide and glucose-induced insulin utilization (euglycemic hyperinsulinemic clamp) in 16 obese (8 nonhyperuricemic and 8 hyperuricemic) and 10 nonobese control subjects. Baseline C-peptide levels were significantly higher in hyperuricemic compared to both nonhyperuricemic obese subjects and controls (P < 0.001). M values, a measure of glucose disposal and insulin sensitivity, were significantly lower in hyperuricemic obese compared to nonhyperuricemic obese subjects and controls (P < 0.001) and, for all subjects were inversely correlated with the serum uric acid values (r = -0.821, P < 0.001). In conclusion, in this group of subjects the serum uric acid values were directly related to insulin resistance independently of age, sex, excess body weight, fat distribution and blood pressure.
authors.affiliation: Istituto di Clinica Medica I, Policlinico Universitario Paolo Giaccone, Palermo, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Sinagra
authors.forename: D
authors.initials: D
authors.lastname: Greco
authors.forename: A M
authors.initials: AM
authors.lastname: Scarpitta
authors.forename: V
authors.initials: V
authors.lastname: Bonaventura
mesh_terms: D000328:Adult; D002096:C-Peptide / Q000097:blood; D005260:Female; D015309:Glucose Clamp Technique; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D000078790:Insulin Secretion; D009765:Obesity / Q000503:physiopathology*; D014527:Uric Acid / Q000097:blood*
chemical_list: D002096:C-Peptide; D007328:Insulin; D014527:Uric Acid