A structural explanation for the twilight zone of protein sequence homology.
Homology modeling of protein structures as a function of sequence breaks down at the twilight zone limit of sequence identity between the template and target proteins. Our results suggest that protein sequences that have diverged from a common ancestor beyond the twilight zone may adopt side-chain interactions that are very different from those endowed by the ancestral sequence.
Chung
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Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. schung@usuhsb.usuhs.mil
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D003198:Computer Simulation; D005544:Forecasting; D008958:Models, Molecular; D011506:Proteins / Q000737:chemistry*; D017386:Sequence Homology, Amino Acid
D011506:Proteins