title: Reversal of fluorosis in children.
abstract: Large populations consume fluoride-contaminated water, especially in developing countries. The toxic effects of fluorosis take three forms: clinical, skeletal and dental. Research thus far indicates that the manifestations of fluorosis are irreversible. However, it has been observed that the ingestion of calcium, vitamin C or vitamin D, individually, is effective in protection from fluoride toxicity to a certain extent. Therefore, a double blind control trial was conducted to examine the effect of a combination of calcium, vitamin D3 and ascorbic acid supplementation in fluorosis-affected children. In the present study, 25 children were selected from an area consuming water containing 4.5 p.p.m. of fluoride, All the children were in the age group 6-12 years and weighed 18-30 kg. They were graded for clinical, radiological and dental fluorosis and relevant biochemical parameters. Grade I skeletal fluorosis and all grades of the manifestation of dental and clinical fluorosis were observed. The children were given ascorbic acid, calcium and vitamin D3 well below the toxic dosages in a double blind manner using lactose as a placebo. Follow up revealed a significant improvement in dental, clinical and skeletal fluorosis and relevant biochemical parameters in these children. Thus, the study indicated that fluorosis can be reversed, at least in children, by a therapeutic regimen that is fairly cheap, simple and easily available and without any side effects.
authors.affiliation: Department of Physiology, SMS Medical College, Jaipur, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Gupta
authors.forename: R C
authors.initials: RC
authors.lastname: Gupta
authors.forename: A K
authors.initials: AK
authors.lastname: Seth
authors.forename: A
authors.initials: A
authors.lastname: Gupta
mesh_terms: D001205:Ascorbic Acid / Q000627:therapeutic use*; D001847:Bone Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000378:metabolism; D002118:Calcium / Q000627:therapeutic use*; D002648:Child; D002762:Cholecalciferol / Q000627:therapeutic use*; D004311:Double-Blind Method; D016903:Drug Monitoring; D004359:Drug Therapy, Combination; D005458:Fluoride Poisoning / Q000150:complications*; D009050:Fluorosis, Dental / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D011859:Radiography; D012720:Severity of Illness Index
chemical_list: D002762:Cholecalciferol; D001205:Ascorbic Acid; D002118:Calcium