Contact dermatitis caused by 2-HEMA and GM dentin primer solutions applied to guinea pigs and humans.
The purposes of this study were to examine whether 2-HEMA, GM, and methacrylic acid cause contact dermatitis, and to determine the optimum concentrations of these primers for sensitization and challenge in guinea pigs. A sensitizing concentration of 0.2% 2-HEMA resulted in strong rubefaction and several vesiculopapules in response to the challenge, and a sensitizing concentration of 0.5% GM produced strong rubefaction at 24 hours. We also observed the development of contact dermatitis on human brachia in a closed-patch test. Skin that was treated with both 2-HEMA and GM clearly showed the onset of rubefaction and itchiness. 2-HEMA caused sensitized delayed allergic reactions at all the concentrations tested.
Katsuno
K
K
Department of Operative Dentistry, School of Dentistry, Showa University, Tokyo, Japan.
Manabe
A
A
Itoh
K
K
Nakamura
Y
Y
Wakumoto
S
S
Hisamitsu
H
H
Yoshida
T
T
D000818:Animals; D017220:Dentin-Bonding Agents / Q000009:adverse effects*; D003813:Dentistry; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000209:etiology; D005989:Glycerides / Q000009:adverse effects*; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D008689:Methacrylates / Q000009:adverse effects*; D010328:Patch Tests
D017220:Dentin-Bonding Agents; D005989:Glycerides; D008689:Methacrylates; C008384:methacrylic acid; C069750:glyceryl methacrylate; C005044:hydroxyethyl methacrylate