[Recent progress of molecular oncology and its contribution to clinical gastroenterology].
Recent progress of molecular oncology has made it possible for us to begin to understand the molecular mechanism for tumor development. However, from a viewpoint of its diagnostic and therapeutic applications, it seems that we have just left a starting line. Even Ki-ras and p53 genes that have been most extensively analysed, their most important clinical significances are considered to be giving us pathogenetic informations at the present time. Of note, allelic loss of chromosome 18q was shown a significant prognostic factor for colorectal cancer patients in stage II. One of most important clinical applications of molecular oncology in near future in our country is diagnosis of hereditary cancer. Analyses of sporadic cases with mutations in hereditary cancer genes will be of special importance.
Imai
K
K
First Department of Internal Medicine, Sapporo Medical University.
Hinoda
Y
Y
D002872:Chromosome Deletion; D002887:Chromosomes, Human, Pair 18; D015179:Colorectal Neoplasms / Q000235:genetics*; D016158:Genes, p53; D011905:Genes, ras; D006801:Humans; D008967:Molecular Biology; D009154:Mutation; D011379:Prognosis