Sindbis virus vectors for expression in animal cells.
Sindbis virus and other alphavirus gene expression vectors have recently been used to express and study the functions of proteins and RNA, to evaluate classical vaccine and novel antiviral approaches, and for nucleic acid immunization. The vectors will likely attract continuing, innovative applications that exploit their useful features: rapid and efficient gene expression, wide host range, and RNA genomes.
Huang
H V
HV
Department of Molecular Microbiology, Washington University School of Medicine, Box 8230, 660 South Euclid Avenue, St. Louis, MO 63110-1093, USA. huang@borcim.wustl.edu
D000818:Animals; D001709:Biotechnology; D015870:Gene Expression; D005822:Genetic Vectors; D009696:Nucleic Acids / Q000276:immunology; D012313:RNA / Q000096:biosynthesis / Q000235:genetics; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000235:genetics; D012845:Sindbis Virus / Q000235:genetics*; D014614:Vaccines, Synthetic / Q000096:biosynthesis / Q000235:genetics; D014765:Viral Vaccines / Q000096:biosynthesis / Q000235:genetics
D009696:Nucleic Acids; C039919:RNA, recombinant; D011994:Recombinant Proteins; D014614:Vaccines, Synthetic; D014765:Viral Vaccines; D012313:RNA