Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism.
The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism (Ames dwarf, df) has been positionally cloned, identifying a novel, tissue-specific, paired-like homeodomain transcription factor, termed Prophet of Pit-1 (Prop-1). The df phenotype results from an apparent failure of initial determination of the Pit-1 lineage required for production of growth hormone, prolactin or thyroid-stimulating hormone, resulting in dysmorphogenesis and failure to activate Pit-1 gene expression. These results imply that a cascade of tissue-specific regulators is responsible for the determination and differentiation of specific cell lineages in pituitary organogenesis.
Sornson
M W
MW
Howard Hughes Medical Institute, University of California at San Diego, La Jolla 92093, USA.
Wu
W
W
Dasen
J S
JS
Flynn
S E
SE
Norman
D J
DJ
O'Connell
S M
SM
Gukovsky
I
I
Carrière
C
C
Ryan
A K
AK
Miller
A P
AP
Zuo
L
L
Gleiberman
A S
AS
Andersen
B
B
Beamer
W G
WG
Rosenfeld
M G
MG
D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D019070:Cell Lineage; D004268:DNA-Binding Proteins / Q000235:genetics*; D004393:Dwarfism, Pituitary / Q000196:embryology / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D018398:Homeodomain Proteins / Q000235:genetics* / Q000502:physiology; D007031:Hypothalamus / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D010903:Pituitary Gland, Anterior / Q000002:abnormalities / Q000196:embryology* / Q000502:physiology; D017354:Point Mutation; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D050817:Transcription Factor Pit-1; D014157:Transcription Factors / Q000235:genetics*
D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D050817:Transcription Factor Pit-1; D014157:Transcription Factors; C494185:Pou1f1 protein, mouse; C102134:Prophet of Pit-1 protein