[Parametric images of central-type benzodiazepine receptor binding and ligand transport by two SPECT scans of 123I-iomazenil: relative quantification without blood data].
Parametric images of intrasubject distribution of the central-type benzodiazepine receptor binding and ligand transport were determined from two SPECT images after an intravenous bolus injection of 123I-iomazenil in six healthy volunteers and five patients by using a table look-up procedure based on a 3-compartment, 2-parameter kinetic model. Individual arterial input functions were estimated by calibrating a standardized input function with the injected dose to avoid blood sampling. The parametric images without blood data provided the same information as those determined by using measured arterial input function. A simulation study suggested that this method gave relatively small error as long as true receptor binding and ligand transport did not differ from each other in a large extent. The present method may be practical in clinical settings.
Onishi
Y
Y
Nihon Medi-Physics Co. Ltd.
Yonekura
Y
Y
Tanaka
F
F
Nishizawa
S
S
Okazawa
H
H
Ishizu
K
K
Fujita
T
T
Konishi
J
J
Mukai
T
T
D001692:Biological Transport; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005442:Flumazenil / Q000031:analogs & derivatives*; D006801:Humans; D007457:Iodine Radioisotopes; D008024:Ligands; D011963:Receptors, GABA-A / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon
D007457:Iodine Radioisotopes; D008024:Ligands; D011963:Receptors, GABA-A; D005442:Flumazenil; C063038:iomazenil