title: The expression of types X and VI collagen and fibrillin in rat mandibular condylar cartilage. Response to mastication forces.
abstract: Types X and VI collagen and fibrillin were localized by in situ hybridization and immunohistochemical methods in the mandibular condyles of rats, and the response of these molecules to post-weaning diets of soft food, ordinary pellets, or hardened pellets was studied. Type X collagen was synthesized, particularly in conditions of soft food consistency, by cells in the perichondrium-periosteum and in the bone and by cells at the erosion front between cartilage and bone. Type X collagen synthesis diminished under higher compression forces due to mastication and with increasing age. Type VI collagen and fibrillin were synthesized by cells in the perichondrium-periosteum and by chondrocytes and by stromal osteoblasts and were not modified by higher mechanical forces. In contrast to previous findings in the growth plate of long bones, type X collagen in the mandibular condyle was not synthesized by hypertrophic chondrocytes but was associated with cells of the osteoblastic rather than the chondroblastic phenotype.
authors.affiliation: Institute of Dentistry, University of Oulu, Finland.
authors.forename: L A
authors.initials: LA
authors.lastname: Salo
authors.forename: J
authors.initials: J
authors.lastname: Hoyland
authors.forename: S
authors.initials: S
authors.lastname: Ayad
authors.forename: C M
authors.initials: CM
authors.lastname: Kielty
authors.forename: A
authors.initials: A
authors.lastname: Freemont
authors.forename: P
authors.initials: P
authors.lastname: Pirttiniemi
authors.forename: T
authors.initials: T
authors.lastname: Kantomaa
authors.forename: M E
authors.initials: ME
authors.lastname: Grant
authors.forename: J T
authors.initials: JT
authors.lastname: Thomas
mesh_terms: D000818:Animals; D002356:Cartilage / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D003094:Collagen / Q000096:biosynthesis*; D005260:Female; D000071837:Fibrillins; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D008335:Mandibular Condyle / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D008409:Mastication / Q000502:physiology; D008840:Microfilament Proteins / Q000096:biosynthesis*; D051381:Rats
chemical_list: D000071837:Fibrillins; D008840:Microfilament Proteins; D003094:Collagen