Ectopic bone formation with the help of growth factor bFGF.
In the present study, basic fibroblast growth factor and a non-resorbable biological matrix (Endobon) were used to help to induce ectopic bone formation in the subdermal fatty tissue of the Göttingen miniature pig. In the early phase, bFGF improved the recipient conditions by enhancing angioneogenesis and helping to provide pluripotent mesenchymal cells. However, vitally transplanted bone cells were necessary in order to ensure successful bone formation. The Endobon only served as an osteoconductive matrix.
Wiltfang
J
J
Department of Oral and Maxillofacial Surgery, University of Göttingen, Germany.
Merten
H A
HA
Wiltfang
J
J
D000273:Adipose Tissue; D000818:Animals; D016026:Bone Marrow Transplantation; D018786:Bone Substitutes; D016025:Bone Transplantation; D002417:Cattle; D017886:Durapatite; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D018919:Neovascularization, Physiologic; D010012:Osteogenesis / Q000187:drug effects*; D010521:Periosteum / Q000637:transplantation; D011098:Polyglactin 910; D019736:Prostheses and Implants; D013552:Swine; D013556:Swine, Miniature
D018786:Bone Substitutes; D016222:Fibroblast Growth Factor 2; C104266:endobon; D011098:Polyglactin 910; D017886:Durapatite