title: Titanium and bioactive glass-ceramic coated titanium as materials for keratoprosthesis.
abstract: The current problem with keratoprosthesis is the ingrowth of corneal or conjunctival epithelium into the anterior chamber. This may lead to infections and extrusion of the prosthesis as well as to the development of retroprosthetic membrane and secondary glaucoma. Glass-ceramic coated and uncoated titanium has been tested as material for the keratoprosthesis to prevent epithelial ingrowth. Twenty-two Supra-Descemet's membrane keratoprostheses were inserted in the eyes of 22 rabbits for 1, 2, 4, 8, or 12 months. The prosthesis had an optic part made of polymethylmetacrylate (PMMA). The support for the optic part and the flange of the prosthesis were made of titanium. Eleven of the prostheses were coated with glass-ceramic. The histological sections of the enucleated eyes were prepared through the central part of the cornea and the prosthesis using a cutting-grinding method. The histological analysis was made on both halves of the implants separately giving two analysis areas in each eye. All 11 titanium prostheses were retained for the time period planned. Two glass-ceramic coated prostheses were lost at 2 and 4 weeks, respectively. This was caused by difficulties at surgery due to a thick coating. These eyes were excluded from the histological analysis. No significant ingrowth of epithelium was seen in 15/18 (83%) and in 16/22 (73%) of the analysed areas of the glass-ceramic coated and titanium prostheses, respectively. Titanium appears to be a suitable material for the keratoprosthesis. The ingrowth of the epithelium may be hindered further by coating the titanium with bioactive glass-ceramic.
authors.affiliation: Department of Ophthalmology, Oulu University Hospital, Finland.
authors.forename: R J
authors.initials: RJ
authors.lastname: Linnola
authors.forename: R P
authors.initials: RP
authors.lastname: Happonen
authors.forename: O H
authors.initials: OH
authors.lastname: Andersson
authors.forename: E
authors.initials: E
authors.lastname: Vedel
authors.forename: A U
authors.initials: AU
authors.lastname: Yli-Urpo
authors.forename: U
authors.initials: U
authors.lastname: Krause
authors.forename: L
authors.initials: L
authors.lastname: Laatikainen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002516:Ceramics; D003315:Cornea / Q000601:surgery*; D004728:Endothelium, Corneal / Q000473:pathology; D005123:Eye / Q000473:pathology; D005898:Glass; D011184:Postoperative Period; D019736:Prostheses and Implants; D011474:Prosthesis Design; D011817:Rabbits; D014025:Titanium
chemical_list: D001672:Biocompatible Materials; D014025:Titanium