Use of the chemical structure of peptides as the starting point to design nonpeptide agonists and antagonists at peptide receptors: examples with cholecystokinin and tachykinins.
This review summarizes a design strategy to give examples of nonpeptides starting from cholecystokinin (CCK-A and -B) and tachykinins (substance P) (NK-1, -2, -3) as potent functional agonists and antagonists with utility as therapeutic agents.
Horwell
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DC
Parke-Davis Neuroscience Research Centre, Cambridge, U.K.
D015195:Drug Design; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D011949:Receptors, Cholecystokinin / Q000819:agonists* / Q000037:antagonists & inhibitors*; D018039:Receptors, Tachykinin / Q000819:agonists* / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D010455:Peptides; D011949:Receptors, Cholecystokinin; D018039:Receptors, Tachykinin