Carpal and tarsal bone development is highly sensitive to three antiproliferative teratogens in mice.
When pregnant mice were given small doses of teratogens (cytosine arabinoside, mitomycin C, or busulfan) that did not induce anomalies of any other organs, a high incidence of carpal and tarsal bone anomalies still occurred. The carpal and tarsal bones may be used as a sensitive target for teratogenicity testing.
Rahman
M E
ME
Department of Hygiene and Preventive Medicine, Yamagata University School of Medicine, Japan.
Ishikawa
H
H
Watanabe
Y
Y
Endo
A
A
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002066:Busulfan / Q000633:toxicity*; D002348:Carpal Bones / Q000002:abnormalities*; D003561:Cytarabine / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D016685:Mitomycin / Q000633:toxicity*; D011247:Pregnancy; D013639:Tarsal Bones / Q000002:abnormalities*
D000970:Antineoplastic Agents; D003561:Cytarabine; D016685:Mitomycin; D002066:Busulfan