title: New 19-acetoxyingol diterpenes from the latex of Euphorbia poisonii (Euphorbiaceae).
abstract: The poisonous latex of Euphorbia poisonii gave bioactive 3,12-diacetyl-8-nicotinyl-7-phenylacetyl 19-acetoxyingol (1) together with its less active congeners, 3,12-diacetyl-7-phenylacetyl 19-acetoxyingol (2) and 3-acetyl-7-phenylacetyl 19-acetoxyingol (3). The chemical structures of 1-3 were determined by spectroscopic methods including HRMS, DEPT, HETCOR, COSY, NOESY, HMQC and HMBC. The absolute configurations of the hydroxylated carbons in 2 and 3 were provisionally suggested by the Mosher ester method. Bioactivity-guided isolation, structure determination and cytotoxic activity of the new ingols are described.
authors.affiliation: Department of Chemistry, Bayero University, Kano, Nigeria.
authors.forename: M O
authors.initials: MO
authors.lastname: Fatope
authors.forename: L
authors.initials: L
authors.lastname: Zeng
authors.forename: J E
authors.initials: JE
authors.lastname: Ohayagha
authors.forename: J L
authors.initials: JL
authors.lastname: McLaughlin
mesh_terms: D000818:Animals; D001156:Artemia; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry*; D005260:Female; D006801:Humans; D007840:Latex / Q000737:chemistry*; D008297:Male; D010944:Plants; D014407:Tumor Cells, Cultured
chemical_list: D004224:Diterpenes; D007840:Latex