Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling.
Acylated homoserine lactones (AHLs) play a widespread role in intercellular communication among bacteria. The Australian macroalga Delisea pulchra produces secondary metabolites which have structural similarities to AHL molecules. We report here that these metabolites inhibited AHL-controlled processes in prokaryotes. Our results suggest that the interaction between higher organisms and their surface-associated bacteria may be mediated by interference with bacterial regulatory systems.
Givskov
M
M
Department of Microbiology, The Technical University of Denmark, Lyngby.
de Nys
R
R
Manefield
M
M
Gram
L
L
Maximilien
R
R
Eberl
L
L
Molin
S
S
Steinberg
P D
PD
Kjelleberg
S
S
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000378:metabolism; D000215:Acylation; D002450:Cell Communication; D005057:Eukaryotic Cells / Q000382:microbiology / Q000502:physiology; D007783:Lactones / Q000378:metabolism*; D011387:Prokaryotic Cells / Q000502:physiology; D000461:Rhodophyta / Q000382:microbiology / Q000502:physiology*; D012705:Serratia / Q000737:chemistry / Q000502:physiology*
D007783:Lactones; C088386:homoserine lactone; D015107:4-Butyrolactone