Monitoring weight drop velocity and foam stiffness as an aid to quality control of a rodent model of impact acceleration neurotrauma.
Since the publication by Marmarou of a new rodent model of head injury, an increasing number of centres are adopting the model for use in a variety of paradigms. We report on two simple methods we have applied which allows us to monitor weight drop velocity and foam stiffness, both of which are critical factors for producing repeatable closed head injury with this model. We hope the application of these methods will assist in the standardisation of this model between centres.
Piper
I R
IR
Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK.
Thomson
D
D
Miller
J D
JD
D000818:Animals; D006259:Craniocerebral Trauma / Q000503:physiopathology*; D004195:Disease Models, Animal; D012377:Rodentia; D013672:Technology / Q000295:instrumentation*