n-3 polyunsaturated fatty acids and human cytokine synthesis.
The cytokines interleukin-1 and tumor necrosis factor contribute to the pathogenesis of inflammatory diseases and, potentially, to atherogenesis. The synthesis of these cytokines in humans can be suppressed by oral intake of n-3 polyunsaturated fatty acids. This mechanism may contribute to the beneficial effect of long-term n-3 fatty acid supplementation in inflammatory diseases such as renal transplant rejection, immunoglobulin A nephropathy and rheumatoid arthritis.
Endres
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Medical Clinic, Ludwig-Maximilians-University, Munich, Germany.
von Schacky
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D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000209:etiology; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000096:biosynthesis*; D015525:Fatty Acids, Omega-3 / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use; D006084:Graft Rejection / Q000188:drug therapy; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000209:etiology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D016207:Cytokines; D015525:Fatty Acids, Omega-3; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha