Teratology study of erythritol in rabbits.
The effect of maternal ingestion of the reduced energy sweetener erythritol was investigated in KBL:JW strain pregnant rabbits. Animals received 1.0, 2.24, or 5.0 g/kg intravenously once daily from Days 6 to 18 of gestation. Maternal effects (auricular edema, and bradypragia) were observed in the high-dose group. No deaths or significant abnormalities occurred in animals given 1.0 or 2.24 g/kg. No effect was observed in the reproductive performance of the dams or in fetal development from ingestion at any of the treatment levels.
Shimizu
M
M
Safety Study Department, Nihon Bioresearch Inc., Gifu, Japan.
Katoh
M
M
Imamura
M
M
Modderman
J
J
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D004896:Erythritol / Q000633:toxicity*; D005260:Female; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011817:Rabbits; D012098:Reproduction / Q000187:drug effects; D013549:Sweetening Agents / Q000633:toxicity*; D013723:Teratogens / Q000633:toxicity*
D013549:Sweetening Agents; D013723:Teratogens; D004896:Erythritol