Big insulin-like growth factor II-producing hepatocellular carcinoma associated with hypoglycemia.
A 76-year-old female with a hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) was hospitalized because of fasting hypoglycemia. Her sera contained a low concentration of immunoreactive insulin and insulin-like growth factor (IGF)-I, while the IGF-II level was normal. However, most of the IGF-II consisted of the high molecular weight form (big IGF-II). The tumor tissue contained fetal type of IGF-II mRNA (6.0 kb). Furthermore, we found that one of the four patients examined with HCV-related HCC had big IGF-II in serum. This indicates that non-islet cell tumor hypoglycemia (NICTH) in HCV-related HCC might be accompanied by production of big IGF-II by the tumor.
Ishida
S
S
Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School.
Noda
M
M
Kuzuya
N
N
Kubo
F
F
Yamada
S
S
Yamanaka
T
T
Isozaki
O
O
Hizuka
N
N
Kanazawa
Y
Y
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D008113:Liver Neoplasms / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*
D007335:Insulin-Like Growth Factor II