title: Diphencyprone in the management of refractory palmoplantar and periungual warts: an open study.
abstract: BACKGROUND
  Induction of delayed-type hypersensitivity has recently been introduced for resistant viral warts. The method is not painful and less destructive than most other modalities.
  
  
  OBJECTIVE
  We assessed the efficacy of topical diphencyprone (diphenylcyclopropenone) treatment for recalcitrant warts.
  
  
  METHODS
  From September 1988 to June 1995, 134 patients with periungual and/or palmoplantar warts were entered into the study. Eight weekly applications were delivered.
  
  
  RESULTS
  The scheduled treatment course and follow-up were completed by 111 patients. There were 49 complete and 18 partial remissions. The rate of positive responders (60%) compares with the results published by other authors.
  
  
  CONCLUSIONS
  Diphencyprone is an effective treatment for resistant warts, especially in palmoplantar and periungual locations.
authors.affiliation: Department of Dermatology, Sint Anna Hospital, Oss, The Netherlands.
authors.forename: F H
authors.initials: FH
authors.lastname: Rampen
authors.forename: P M
authors.initials: PM
authors.lastname: Steijlen
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use*; D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000368:Aged; D003521:Cyclopropanes / Q000008:administration & dosage / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D005533:Foot Dermatoses / Q000188:drug therapy* / Q000276:immunology; D006229:Hand Dermatoses / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009260:Nail Diseases / Q000188:drug therapy* / Q000276:immunology; D012074:Remission Induction; D014860:Warts / Q000188:drug therapy* / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D003521:Cyclopropanes; D003879:Dermatologic Agents; C029402:diphenylcyclopropenone