Hyperlipidemia and the rheumatic diseases.
Premature atherosclerosis is a recognized complication of systemic lupus erythematosus. Atherosclerosis begins in the pediatric age group, and interventions directed toward prevention should begin in childhood as well. A possible cause of premature atherosclerosis is dyslipoproteinemia from the underlying chronic inflammatory disease or from corticosteroid therapy. A relationship between dyslipoproteinemia and anticardiolipin antibodies has been demonstrated. Dietary therapy is helpful, but many patients continue to have significant dyslipoproteinemia after both dietary modification and fish oil supplementation. Lipid-lowering drugs may be indicated in this subgroup. Potential mechanisms of dyslipoproteinemia are discussed.
Ilowite
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Schneider Children's Hospital, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA.
D000818:Animals; D017152:Antibodies, Antiphospholipid; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D008074:Lipoproteins / Q000097:blood; D012216:Rheumatic Diseases / Q000097:blood / Q000150:complications* / Q000503:physiopathology / Q000628:therapy
D017152:Antibodies, Antiphospholipid; D008074:Lipoproteins