Investigation of anti-inflammatory and antinociceptive activities of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara. Part 1.
The anti-inflammatory and antinociceptive effects of trans-dehydrocrotonin, isolated from the bark of Croton cajucara (Euphorbiaceae), were investigated using several animal models. The trans-dehydrocrotonin produced a significant inhibition of carrageenin-induced paw edema and cotton pellet granuloma in rats. It also inhibited the writhings in mice induced by acetic acid, but did not show a significant effect in the hot-plate test in mice. The LD50 of t-DCTN was 555.0 mg/kg (p.o.) for mice.
Carvalho
J C
JC
Departamento de Princípios Ativos Naturais e Toxicologia, Faculdade de Ciências Farmacêuticas-UNESP, Araraquara, São Paulo, Brasil.
Silva
M F
MF
Maciel
M A
MA
Pinto
A C
AC
Nunes
D S
DS
Lima
R M
RM
Bastos
J K
JK
Sarti
S J
SJ
D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D001938:Brazil; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D045785:Diterpenes, Clerodane; D006099:Granuloma; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D010146:Pain; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes; D045785:Diterpenes, Clerodane; C103060:dehydrocrotonin; D009020:Morphine