Jack A. Barney Resident Research Award winner. The inflammatory profile of interleukin-6, interleukin-8, and soluble intercellular adhesion molecule-1 in postinjury multiple organ failure.
BACKGROUND
Interleukin-6 (IL-6), interleukin-8 (IL-8), and adhesion molecules have been implicated as mediators in neutrophil (PMN) and endothelial cell (EC) interactions leading to postinjury multiple organ failure (MOF). Our hypothesis was that circulating levels of IL-6, IL-8, and soluble intercellular adhesion molecule-1 (sICAM-1) would discriminate patients at risk for postinjury MOF.


METHODS
Serial plasma levels of IL-6, IL-8, and sICAM-1 were measured in 27 high-risk trauma patients.


RESULTS
The IL-6 and IL-8 levels were significantly elevated in MOF patients compared with non-MOF patients at 12 and 36 hours postinjury. The IL-6 level was also elevated at 84 and 132 hours, and IL-8 at 84 hours. The sICAM-1 level did not become elevated in MOF patients until 132 hours postinjury.


CONCLUSIONS
Interleukin-6 and IL-8 are elevated early after trauma and discriminate patients who will develop MOF. Late elevation of sICAM-1 likely results from PMN cytotoxicity leading to EC injury or inflammation.
Partrick
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Department of Surgery, Denver General Hospital, University of Colorado Health Sciences Center, Denver, USA.
Moore
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Moore
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Biffl
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Sauaia
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Barnett
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D000328:Adult; D001363:Awards and Prizes; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D009102:Multiple Organ Failure / Q000209:etiology / Q000276:immunology*; D011446:Prospective Studies; D012307:Risk Factors; D014947:Wounds and Injuries / Q000150:complications* / Q000276:immunology
D015850:Interleukin-6; D016209:Interleukin-8; D018799:Intercellular Adhesion Molecule-1