title: [Prostaglandin E1 at low-doses improved right ventricular ejection fraction in anesthetic management for CABG].
abstract: A 52-year-old male for CABG developed a severe right heart failure, because of the direct injury to the right ventricular wall, after cardiopulmonary bypass. The volume loading therapy could not improve the cardiac function, then we used an infusion of low-dose prostaglandin E1 (0.02-0.04 micrograms.kg-1.min-1) for the acute right heart failure with increased pulmonary vascular resistance. After continuous infusion of this dose, the pulmonary vascular resistance decreased quickly, the right ventricular ejection fraction increased, and the stroke volume index also improved. These hemodynamic changes are the result of the potent vasodilating effect of PGE1, that especially could decrease selectively the pulmonary vascular resistance, and increase the preload of the left ventricle. This dose of PGE1, did not cause a severe systemic hypertension that is a serious complication during vasodilating therapy with any vasoactive drugs. In the present case, we speculated that the low-dose PGE1, is effective to improve the right ventricular function during the acute right heart failure which resulted from the intrinsic right ventricular dysfunction.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Gifu University School of Medicine.
authors.forename: H
authors.initials: H
authors.lastname: Oohata
authors.forename: N
authors.initials: N
authors.lastname: Ueda
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
authors.forename: S
authors.initials: S
authors.lastname: Akamatsu
authors.forename: H
authors.initials: H
authors.lastname: Shimonaka
authors.forename: S
authors.initials: S
authors.lastname: Dohi
mesh_terms: D000527:Alprostadil / Q000008:administration & dosage* / Q000494:pharmacology; D000758:Anesthesia / Q000379:methods*; D001026:Coronary Artery Bypass; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume / Q000187:drug effects*; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000494:pharmacology; D018497:Ventricular Dysfunction, Right / Q000188:drug therapy; D016278:Ventricular Function, Right / Q000187:drug effects*
chemical_list: D014665:Vasodilator Agents; D000527:Alprostadil