Synthesis and antibacterial testing of some new quinolines, pyridazinoquinolines and spiroindoloquinolines.
3-Dicyanomethylideneindole derivatives were involved in (i) ring expansion reactions in alcoholic piperidine to form new quinolines from which a new pyridazinoquinoline was synthesised; and (ii) formation of new spiroindoloquinolines by reactions with cyclohexanone and beta-tetralone. The suggested structures of the new products were confirmed by IR, 1H-NMR, 13C-NMR and mass spectral analyses. Some of the new derivatives were active against the bacteria Escherichia cell.
el-Ahl
A A
AA
Chemistry Department, Faculty of Science at Mansoura, Egypt.
Mashaly
M M
MM
Metwally
M A
MA
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects*; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology
D042462:4-Quinolones; D000890:Anti-Infective Agents; D007211:Indoles; D011724:Pyridazines; D011804:Quinolines