title: The effect of clozapine on saliva flow rate: a pilot study.
abstract: This study examined the effect of clozapine on saliva flow rate. Unstimulated whole saliva was collected from 9 patients taking clozapine (dose range = 50-400 mg/day) and from 8 controls who had never used clozapine. There was no significant difference between the average saliva flow rates in the two groups (p > .10), nor was there significant correlation between saliva flow rate and daily clozapine dose (p > .10). Alternative explanations for observations or complaints of excessive salivation, drooling, or a choking feeling while taking clozapine are proposed.
authors.affiliation: McLean Hospital, Belmont, Massachusetts, USA.
authors.forename: T
authors.initials: T
authors.lastname: Rabinowitz
authors.forename: F R
authors.initials: FR
authors.lastname: Frankenburg
authors.forename: F
authors.initials: F
authors.lastname: Centorrino
authors.forename: J
authors.initials: J
authors.lastname: Kando
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D003024:Clozapine / Q000009:adverse effects*; D006801:Humans; D010865:Pilot Projects; D012472:Salivation / Q000187:drug effects*; D012798:Sialorrhea / Q000139:chemically induced
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine