title: Eosinophilia and granulocytic dysplasia terminating in acute myeloid leukaemia after 24 years.
abstract: Eosinophilia of variable duration, and subsequent progression to granulocytic sarcoma and acute myeloid leukaemia, has been infrequently reported in the literature. We report a patient with eosinophilia and normal cytogenetics who, after 24 years, showed transformation to a granulocytic sarcoma of the brain. Haematological counts were normal but the marrow revealed the cytogenetic abnormality trisomy 8 in 25% of mitoses. Subsequently an AML-M2 developed, showing a complex karyotype including the trisomy 8 in all metaphases. FISH analysis combined with cytological examination identified the trisomy 8 in blasts, eosinophils and dysplastic granulocytes only. Thus progressive leukaemic transformation selectively involved the myeloid compartment.
authors.affiliation: Department of Haematology, University Hospital Rotterdam, The Netherlands.
authors.forename: J K
authors.initials: JK
authors.lastname: Doorduijn
authors.forename: K
authors.initials: K
authors.lastname: van Lom
authors.forename: B
authors.initials: B
authors.lastname: Löwenberg
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000209:etiology; D002471:Cell Transformation, Neoplastic; D002898:Chromosomes, Human, Pair 8; D018450:Disease Progression; D004802:Eosinophilia / Q000150:complications*; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D014314:Trisomy