Isolation of two cytotoxic diterpenes from the fern Pteris multifida.
From aerial parts of the fern Pteris multifida Poir. (Polypodiaceae) two diterpenes, entkaurane-2 beta, 16 alpha-diol and ent-kaur-16-ene-2 beta, 15 alpha-diol, were isolated by repeated column chromatography using silica gel and silica gel impregnated with silver nitrate. The structures were confirmed by spectroscopic methods. Both compounds showed a moderate cytotoxicity to Ehrlich ascites tumour cells.
Woerdenbag
H J
HJ
Department of Pharmaceutical Biology, University Centre for Pharmacy, Groningen Institute for Drug Studies (GIDS), University of Groningen, The Netherlands.
Lutke
L R
LR
Bos
R
R
Stevens
J F
JF
Hulst
R
R
Kruizinga
W H
WH
Zhu
Y P
YP
Elema
E T
ET
Hendriks
H
H
van Uden
W
W
Pras
N
N
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D002286:Carcinoma, Ehrlich Tumor; D002455:Cell Division; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity*; D008516:Medicine, Chinese Traditional; D051379:Mice; D015394:Molecular Structure; D010946:Plants, Medicinal; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004224:Diterpenes