A myeloproliferative disorder with eosinophilia associated with a unique translocation (3;5).
An association between eosinophilia and a structural chromosome abnormality has been noted in patients with acute non-lymphoblastic leukaemia (ANLL) and a deletion of the long arm of chromosome 16. There have been a number of other associations of specific chromosome abnormalities with neoplastic diseases involving the eosinophilic lineage; these include chromosome 12 short arm rearrangements, trisomy 8, t(8;21), t(5;14) and t(5;12). We report a patient with a myeloproliferative disorder characterized by chronic eosinophilic leukaemia complicated by autoimmune haemolytic anaemia and a previously unreported translocation (3;5)(p13;q13), and discuss the possible contribution of the RASA gene, localized to 5q13.3, to the development of the malignant phenotype.
Shanske
A L
AL
Department of Pediatrics, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA.
Kalman
A
A
Grunwald
H
H
D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3; D002895:Chromosomes, Human, Pair 5; D005260:Female; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications / Q000235:genetics*; D007621:Karyotyping; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000150:complications / Q000235:genetics*; D014178:Translocation, Genetic