title: Metabolic responses during initial days of altitude acclimatization in the eastern Himalayas.
abstract: The study was carried out on 16 men (aged 20-30 years) to evaluate daily metabolic responses during the early phase of altitude acclimatization at moderate altitudes between 3100 and 4200 m in the Eastern Himalayas. Resting (R) and submaximal exercise (E) oxygen consumption (IVO2) at 100 W at sea level (SL) were 3.25 (SEM 0.15) and 20.31 (SEM 0.77) ml/kg per min respectively. On day 1 at 3110 m both R and E IVO2 decreased (P < 0.001) and subsequently remained constant. At 3445 m these values tended to increase over the 3110 m values but were lower than the SL values. At 4177 m the decline in IVO2 was significantly greater (P < 0.01) than at the preceding altitudes. Pulmonary ventilation (IVE) increased consistently (P < 0.001) with increase in altitude. The arterial oxygen saturation (SaO2) at different altitudes was lower (P < 0.001) than SL values. The cardiac frequency (fC) at R and E was higher (P < 0.001) at altitude; the values at 3110 and 3445 m were significantly lower (P < 0.001) than at 4177 m. Blood pressure (BP) increased (P < 0.001) on the first day at each altitude. The systolic BP tended to decline towards SL values but the diastolic BP remained high (P < 0.001) throughout. The resting blood lactic acid concentration, [la-]bl, showed a decline (P < 0.001) only at 4177 m. The [la-]bl at E was similar at 3110 and 3445 m but was higher (P < 0.01) at 4177 m. These observations suggest that acclimatization to a mid-altitude of 3445 m can be safely avoided where rapid ascent to higher altitude is required.
authors.affiliation: Defence Institute of Physiology and Allied Sciences, Delhi, India.
authors.forename: C K
authors.initials: CK
authors.lastname: Basu
authors.forename: R K
authors.initials: RK
authors.lastname: Gautam
authors.forename: R P
authors.initials: RP
authors.lastname: Sharma
authors.forename: H
authors.initials: H
authors.lastname: Kumar
authors.forename: O S
authors.initials: OS
authors.lastname: Tomar
authors.forename: R C
authors.initials: RC
authors.lastname: Sawhney
authors.forename: W
authors.initials: W
authors.lastname: Selvamurthy
mesh_terms: D000064:Acclimatization / Q000502:physiology*; D000328:Adult; D000531:Altitude; D000532:Altitude Sickness / Q000209:etiology / Q000503:physiopathology; D001794:Blood Pressure; D006339:Heart Rate; D006801:Humans; D007194:India; D019344:Lactic Acid / Q000097:blood; D008297:Male; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D012119:Respiration
chemical_list: D019344:Lactic Acid; D010100:Oxygen