Endosome dynamics regulated by a Rho protein.
Vesicular transport is a dynamic process that requires coordinated interactions between membrane and cytoskeleton. The mechanisms and molecules integrating these interactions are unclear. A Rho protein, RhoD, might provide a molecular link between membrane traffic and the cytoskeleton. Activated RhoD causes rearrangements of the actin cytoskeleton and cell surface, and governs early endosome motility and distribution.
Murphy
C
C
European Molecular Biology Laboratory, Heidelberg, Germany.
Saffrich
R
R
Grummt
M
M
Gournier
H
H
Rybin
V
V
Rubino
M
M
Auvinen
P
P
Lütcke
A
A
Parton
R G
RG
Zerial
M
M
D000199:Actins / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001692:Biological Transport; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism*; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D006801:Humans; D051379:Mice; D018715:Microscopy, Video; D008969:Molecular Sequence Data; D009154:Mutation; D011506:Proteins / Q000378:metabolism*; D011990:Receptors, Transferrin / Q000378:metabolism; D011994:Recombinant Proteins / Q000378:metabolism; D020741:rho GTP-Binding Proteins
D000199:Actins; D011506:Proteins; D011990:Receptors, Transferrin; D011994:Recombinant Proteins; C105243:RHOD protein, human; C491334:Rhod protein, mouse; D020558:GTP Phosphohydrolases; D020741:rho GTP-Binding Proteins