title: Fractionated stereotactic radiation therapy for intracranial arteriovenous malformations.
abstract: Fractionation of radiotherapy is a radiobiological advantage because the radiation effects on healthy brain tissue are reduced. We used fractionated stereotactic radiotherapy for cerebral arteriovenous malformations employing a modified linear accelerator and a noninvasive stereoadaptor. The treatment was given in two sessions (1,400 cGy x 2). Control angiography at least 2 years after treatment was performed on 20 patients. The malformation was completely eliminated in 14 of 15 patients with small arteriovenous malformations. None of the 5 patients with large malformations had their lesion eliminated, but in 4 the malformation was significantly reduced. Fractionated stereotactic radiation therapy using a conventional accelerator is an effective and safe technique in the treatment of intracranial arteriovenous malformations and compares favorably to radiosurgery.
authors.affiliation: Department of Neurosurgery, Rikshospitalet, Oslo, Norway.
authors.forename: O J
authors.initials: OJ
authors.lastname: Kirkeby
authors.forename: S
authors.initials: S
authors.lastname: Bakke
authors.forename: K
authors.initials: K
authors.lastname: Tveraa
authors.forename: H
authors.initials: H
authors.lastname: Hirschberg
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery; D013238:Stereotaxic Techniques; D016896:Treatment Outcome