Study of therapeutic efficiency of new blood substitutes in experimental hemorrhagic shock.
In experiments on dogs, which were anesthetized and underwent hemorragic shock, the hemodynamics, oxygen transport and acid-base status were studied. Cardiac function was studied using ultrasound equipment. It was established that administration of Volekam and Polyoxidin corrects hypovolemia with subsequent restoration of arterial pressure in the aorta and cardiac cavities and increase in the myocard contractility and cardiac output. Comparative analysis has shown that Polyoxidin exerts a more prolonged action than Volekam. In addition, Polyoxidin decreases the blood and plasma viscosity, lowers the blood cells aggregation which promotes the restoration of peripheral circulation. The efficiency of Volekam and Polyoxidin is not inferior to that of the well known blood substitute Polyglukin (dextran group) and, in respect of some parameters, is even superior to that of the latter.
Kochetygov
N I
NI
Russian Research Institute of Hematology and Transfusiology, Laboratory of Pathophysiology and Laboratory of Blood Substitute, S. Petersburg, Russia.
Gorkoun
A V
AV
Gerbut
K A
KA
Sedova
L A
LA
Mikhailova
L G
LG
D000818:Animals; D001802:Blood Substitutes / Q000627:therapeutic use*; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D005740:Gases / Q000097:blood; D006439:Hemodynamics / Q000187:drug effects; D006895:Hydroxyethyl Starch Derivatives / Q000627:therapeutic use*; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D012771:Shock, Hemorrhagic / Q000628:therapy*
D001802:Blood Substitutes; D005740:Gases; D006895:Hydroxyethyl Starch Derivatives; D011092:Polyethylene Glycols