title: Synergistic signals in the environment.
abstract: Numerous endogenous signals (such as hormones and growth factors) or environmental signals (including chemicals or temperature) contribute to determining the overall biological response produced by cells. Some combinations of endogenous or environmental signals produce synergistic activity. This commentary examines the different types of interactions between signals that contribute to synergy at the biological level.
authors.affiliation: Tulane-Xavier Center for Bioenvironmental Research, Environmental Endocrinology Project, New Orleans, LA 70112, USA.
authors.forename: S F
authors.initials: SF
authors.lastname: Arnold
authors.forename: J A
authors.initials: JA
authors.lastname: McLachlan
mesh_terms: D000818:Animals; D004357:Drug Synergism; D004785:Environmental Pollutants / Q000633:toxicity*; D004967:Estrogens / Q000633:toxicity*; D006358:Hot Temperature; D006801:Humans; D011078:Polychlorinated Biphenyls / Q000633:toxicity
chemical_list: D004785:Environmental Pollutants; D004967:Estrogens; D011078:Polychlorinated Biphenyls