title: Evaluation of the disinfectant effect of Solprogel against human immunodeficiency virus type 1 (HIV-1).
abstract: The antiviral activities of sodium dichloroisocyanurate (NaDCC) and a commercial product (Solprogel 2%) against human immunodeficiency virus type 1 (HIV-1) were investigated using a quantitative suspension test method. Solprogel is a compound that contains NaDCC and a biodegradable polymer of acrylic acid. Viral suspensions were prepared containing 3.2 x 10(6) tissue culture infective dose 50 (TCID50) in culture media. Syncytium formation in the MT-2 line and HIV antigen p24 on the supernatant of the cultures were used to determine viral titre. Results indicate that satisfactory disinfection (1000-fold reduction in 5 min) can be achieved using NaDCC and Solprogel at concentrations of 100 and 120 ppm available chlorine, respectively.
authors.affiliation: Servicio de Microbiología, Hospital Universitario Germans Trias i Pujol, Universidad Autónoma de Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Hernández
authors.forename: F J
authors.initials: FJ
authors.lastname: Belda
authors.forename: J
authors.initials: J
authors.lastname: Domínguez
authors.forename: L
authors.initials: L
authors.lastname: Matas
authors.forename: M
authors.initials: M
authors.lastname: Gimenez
authors.forename: M
authors.initials: M
authors.lastname: Caraballo
authors.forename: C
authors.initials: C
authors.lastname: Ramil
authors.forename: V
authors.initials: V
authors.lastname: Ausina
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D005782:Gels; D015726:Giant Cells / Q000821:virology; D015488:HIV Antigens / Q000378:metabolism; D015658:HIV Infections / Q000517:prevention & control*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D017758:Infectious Disease Transmission, Patient-to-Professional / Q000517:prevention & control*; D014227:Triazines / Q000494:pharmacology*; D014773:Virology / Q000379:methods
chemical_list: D000998:Antiviral Agents; D005782:Gels; D015488:HIV Antigens; D014227:Triazines; C011765:troclosene