title: Synthesis, structure, and spectroscopic properties of acetato(dimethyl)(pyridine-2-carbaldehydethiosemicarbazonato)tin(IV) acetic acid solvate, [SnMe2(PyTSC)(OAc)].HOAc. Comparison of its biological activity with that of some structurally related diorganotin(IV) bis(thiosemicarbazonates).
abstract: The synthesis, X-ray structure, behavior in solution, and biological properties of the complex [SnMe2(PyTSC)(OAc)].HOAc (HPyTSC = pyridine-2-carbaldehydethiosemicarbazone) are reported. The tin atom of this complex is coordinated to an N,N,S-tridentate PyTSC- anion, to a monodentate acetate ion, and to the two methyl groups in an approximately pentagonal bipyramidal environment with a vacant equatorial position. The complex partially evolves in DMSO and in DMSO/CHxCl4-x (X = 1, 2) mixtures, giving HPyTSC and SnMe2(OAc)2. [SnMe2 (PyTSC)(OAc)].HOAc, [SnMe2(DAPTSC)], and [SnPh2(DAPTSC)].2DMF (H2DAPTSC = 2,6-diacetylpyridine bis(thiosemicarbazone)) all suppress proliferation of Friend erythroleukaemia cells (FLC). DMSO-induced differentiation of FLC is slightly suppressed by [SnMe2(DAPTSC)] and is unaffected by [SnPh2(DAPTSC)].2DMF and [SnMe2(PyTSC)(OAc)].HOAc.
authors.affiliation: Departamento de Química Inorgánica, Universidade de Santiago de Compostela, Galicia, Spain.
authors.forename: J S
authors.initials: JS
authors.lastname: Casas
authors.forename: M S
authors.initials: MS
authors.lastname: García-Tasende
authors.forename: C
authors.initials: C
authors.lastname: Maichle-Mössmer
authors.forename: M C
authors.initials: MC
authors.lastname: Rodríguez-Argüelles
authors.forename: A
authors.initials: A
authors.lastname: Sánchez
authors.forename: J
authors.initials: J
authors.lastname: Sordo
authors.forename: A
authors.initials: A
authors.lastname: Vázquez-López
authors.forename: S
authors.initials: S
authors.lastname: Pinelli
authors.forename: P
authors.initials: P
authors.lastname: Lunghi
authors.forename: R
authors.initials: R
authors.lastname: Albertini
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D018360:Crystallography, X-Ray; D005622:Friend murine leukemia virus; D004915:Leukemia, Erythroblastic, Acute / Q000188:drug therapy; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D009947:Organotin Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012996:Solutions; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D009947:Organotin Compounds; D012996:Solutions; C099130:acetato(dimethyl)(pyridine-2-carbaldehydethiosemicarbazonato)tin(IV)