2-hydroxyestrone: the 'good' estrogen.
The issue of the role of 2-hydroxyestrone (2-OHE1) in breast cancer has been the subject of considerable controversy as to whether it is carcinogenic or anticarcinogenic. The expanding data base outlined below is most consistent with the conclusion that 2-OHE1 is anticarcinogenic. In every experimental model in which 2-hydroxylation was increased, protection against tumors was achieved. Correspondingly, when 2-hydroxylation was decreased, an increase in cancer risk was observed. Even more dramatically, in the case of laryngeal papillomas induction of 2-hydroxylation with indole-3-carbinol (I3C) has resulted in inhibition of tumor growth during the time that the patients continue to take 13C or vegetables rich in this compound.
Bradlow
H L
HL
Strang Cancer Research Laboratory, New York, New York 10021, USA.
Telang
N T
NT
Sepkovic
D W
DW
Osborne
M P
MP
D016588:Anticarcinogenic Agents / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000517:prevention & control; D002393:Estrogens, Catechol / Q000378:metabolism*; D005260:Female; D006801:Humans; D006894:Hydroxyestrones / Q000378:metabolism*; D006900:Hydroxylation
D016588:Anticarcinogenic Agents; D002393:Estrogens, Catechol; D006894:Hydroxyestrones; C024980:2-hydroxyestrone