Isoflurane hepatotoxicity: a case report and review of the literature.
Isoflurane, hailed as the anesthetic of the 1980s, is less hepatotoxic than its predecessors, halothane and enflurane. Since its release by the Food and Drug Administration in 1979, controversy has existed about the extent to which isoflurane is capable of producing hepatotoxic effects. In this report, we provide direct evidence that isoflurane can induce liver injury and should therefore be considered as a potential cause of serum transaminase elevations in any patient who is exposed to this anesthetic.
Sinha
A
A
Department of Family Practice, Christ Hospital and Medical Center, Oak Lawn, Illinois, USA.
Clatch
R J
RJ
Stuck
G
G
Blumenthal
S A
SA
Patel
S A
SA
D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D001219:Aspartate Aminotransferases / Q000097:blood; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D007530:Isoflurane / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron
D018685:Anesthetics, Inhalation; D007530:Isoflurane; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase