In utero haematopoietic stem cell transplantation: current perspectives and future potential.
In utero transplantation (IUT) of haematopoietic cells is a new therapeutic option for families with increased risk of having a child with an inherited disorder. Immunological naiveté and the rapidly expanding haematopoietic system in the first trimester human fetus, make therapeutic intervention by IUT a real possibility for those disorders which can be diagnosed early in gestation. Fewer cells are required than in postnatal BMT and therapy can be offered before the pathological sequelae of a disorder become manifested. However, only a few cases of IUT have been performed in humans and it is imperative that consensus is reached quickly on issues such as cell numbers/cell types so that the benefits of this approach to treatment can be realised. This review presents the current status of IUT, the cases thus far recorded and offers a prospective view of developments in this rapidly expanding area.
Jones
D R
DR
Department of Immunology, University Hospital Queen's Medical Centre, Nottingham, UK.
Bui
T H
TH
Anderson
E M
EM
Ek
S
S
Liu
D
D
Ringdén
O
O
Westgren
M
M
D005260:Female; D005315:Fetal Diseases / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D011247:Pregnancy; D011295:Prenatal Care; D014599:Uterus