The influence of gastrin and/or cholecystokinin antagonists on the proliferation of three human astrocytic tumor cell lines.
We have investigated the potential role of gastrin in the regulation of cell growth in human astrocytic tumors. To this end we have used synthetic analogs of gastrin and cholecystokinin (CCK) which behave as gastrin and/or CCK antagonists, e.g. compounds JMV-97, JMV-209 and JMV-179. Their effects on astrocytic tumor cell proliferation was investigated by the use of the colorimetric MTT assay. The in vitro biological models used in the present study included the SW1088, U87 and U373 astrocytic tumor cell lines. The results demonstrated marked influence of gastrin and CCK antagonists in the regulation of astrocytic tumor growth. This suggests that gastrin and/or CCK antagonists might be tested in experimental glioblastoma.
Camby
I
I
Laboratoire d'Histologie, Faculté de Médecine, Université Libre de Bruxelles, Belgium.
Salmon
I
I
Oiry
C
C
Galleyrand
J C
JC
Nagy
N
N
Danguy
A
A
Brotchi
J
J
Pasteels
J L
JL
Martinez
J
J
Kiss
R
R
D001253:Astrocytes / Q000473:pathology*; D001254:Astrocytoma / Q000473:pathology*; D001932:Brain Neoplasms / Q000473:pathology*; D002766:Cholecystokinin / Q000037:antagonists & inhibitors* / Q000502:physiology; D005755:Gastrins / Q000037:antagonists & inhibitors* / Q000494:pharmacology* / Q000502:physiology; D005909:Glioblastoma / Q000473:pathology*; D006801:Humans; D010446:Peptide Fragments / Q000494:pharmacology*; D012844:Sincalide / Q000031:analogs & derivatives* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D005755:Gastrins; C104771:JMV 209; C104772:JMV 97; D010446:Peptide Fragments; C070096:JMV 179; D002766:Cholecystokinin; D012844:Sincalide