title: Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana.
abstract: A crude methanolic extract of the fruit hull of Mangosteen, Garcinia mangostana L. inhibited the contractions of isolated thoracic rabbit aorta induced by histamine and serotonin. The extract of the fruit hull has been fractionated by silica gel chromatography, monitoring the pharmacological activity to give alpha- and gamma-mangostin. On the basis of pharmacological data, it is suggested that alpha-mangostin and gamma-mangostin are a histaminergic and a serotonergic receptor blocking agent, respectively.
authors.forename: N
authors.initials: N
authors.lastname: Chairungsrilerd
authors.forename: K
authors.initials: K
authors.lastname: Furukawa
authors.forename: T
authors.initials: T
authors.lastname: Ohta
authors.forename: S
authors.initials: S
authors.lastname: Nozoe
authors.forename: Y
authors.initials: Y
authors.lastname: Ohizumi
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000502:physiology; D001208:Asia; D006633:Histamine Antagonists / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D066298:In Vitro Techniques; D015394:Molecular Structure; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D010946:Plants, Medicinal; D011817:Rabbits; D012702:Serotonin Antagonists / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014197:Trees; D014966:Xanthenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D044004:Xanthones
chemical_list: D006633:Histamine Antagonists; D012702:Serotonin Antagonists; D014966:Xanthenes; D044004:Xanthones; C021053:mangostin