Fate of erythritol after single oral administration to rats and dogs.
The absorption and distribution of radiolabeled erythritol were studied in Wistar rats and beagle dogs after a single oral administration in doses ranging from 0.125 to 2.0 g erythritol/kg body wt. Erythritol concentrations in blood and plasma of rats reached their maxima 1 hr after administration and then declined biexponentially. In the blood and plasma of dogs, the highest concentrations occurred after 1/2 hr followed by a similar decline. Blood plasma distribution ratios and plasma protein binding ratios increased as blood plasma levels declined. At 120 hr after administration, 95.68 +/- 2.25% of the radioactivity had been excreted in the urine of dogs and 92.70 +/- 0.44% in the urine of rats; 0.33 +/- 0.05% had been excreted in the feces of dogs and 1.19 +/- 0.09% in the feces of rats; 1.17 +/- 0.04% had been excreted in expired air from dogs and 4.80 +/- 0.32% in expired air from rats. The results demonstrate that erythritol is rapidly absorbed and excreted, principally through the urinary pathway.
Noda
K
K
Division of Metabolism, Omiya Research Laboratory, Nikken Chemicals Co., Ltd, Saitama, Japan.
Nakayama
K
K
Modderman
J
J
D000284:Administration, Oral; D000818:Animals; D001345:Autoradiography; D001659:Biliary Tract / Q000378:metabolism; D001773:Blood Cells / Q000378:metabolism; D002250:Carbon Radioisotopes; D004285:Dogs; D004896:Erythritol / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D005243:Feces; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013549:Sweetening Agents / Q000378:metabolism / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D013549:Sweetening Agents; D004896:Erythritol