title: Individual variation in recombination among human males.
abstract: Studies of recombination between the markers D6S291 and D6S109 in individuals by sperm typing provide direct evidence for significant variation in recombination among humans. A statistically significant difference in the recombination fraction (range 5.1%-11.2%) was detected among five donors. This variation could reflect polymorphisms in genes affecting recombination or in chromosome structure. Ignoring this variability in studies designed to examine the relationship between physical and genetic distances could lead to incorrect inferences. Individual variation in recombination makes it difficult to predict the recombination fraction for an interval in any particular individual. This could be important in certain genetic counseling situations.
authors.affiliation: Molecular Biology Program, University of Southern California, Los Angeles 90089-1340, USA.
authors.forename: J
authors.initials: J
authors.lastname: Yu
authors.forename: L
authors.initials: L
authors.lastname: Lazzeroni
authors.forename: J
authors.initials: J
authors.lastname: Qin
authors.forename: M M
authors.initials: MM
authors.lastname: Huang
authors.forename: W
authors.initials: W
authors.lastname: Navidi
authors.forename: H
authors.initials: H
authors.lastname: Erlich
authors.forename: N
authors.initials: N
authors.lastname: Arnheim
mesh_terms: D000328:Adult; D005819:Genetic Markers; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008875:Middle Aged; D011995:Recombination, Genetic / Q000235:genetics*; D013094:Spermatozoa
chemical_list: D005819:Genetic Markers