title: Dextromoramide pharmacokinetics following sublingual administration.
abstract: The extent of absorption and other pharmacokinetic parameters of dextromoramide following sublingual administration were assessed in five patients receiving chronic opioid analgesia. The use of the standard 5 mg tablet formulation was associated with negligible absorption in two patients, a prolonged time to peak concentration in the other three and substantial variability in clearance. The study concluded that the standard tablet formulation cannot be recommended for sublingual use where reliable, rapid onset analgesia is required.
authors.affiliation: Department of Pharmacy, Queen Elizabeth Hospital, Woodville, South Australia.
authors.forename: T E
authors.initials: TE
authors.lastname: Jones
authors.forename: R G
authors.initials: RG
authors.lastname: Morris
authors.forename: N C
authors.initials: NC
authors.lastname: Saccoia
authors.forename: D
authors.initials: D
authors.lastname: Thorne
mesh_terms: D000042:Absorption; D000286:Administration, Sublingual; D000368:Aged; D000698:Analgesia / Q000379:methods; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003916:Dextromoramide / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D000701:Analgesics, Opioid; D003916:Dextromoramide