title: [The significance of neurological manifestations from the aspect of aggressology].
abstract: The pathophysiological processes of the nervous system observed in the reactions to aggressive external stresses like severe trauma, systemic infection and so on have been reviewed. As is generally understood, such stresses as tissue destruction lead to the metabolic changes via proprioceptive impulses to central nervous system and neuroendocrinological courses. Cytokines are well known to work to induce systemic inflammatory responses and also to be important components of sepsis syndrome, for example. In the early phase of septic encephalopathy without overt infection of the brain or the meninges, it is possible that cytokines cause capillary leakage with brain edema, interference with microcirculation and direct effects on tissue metabolism resulting in brain dysfunction. And besides, Interleukins are prove to be produced in a few hours post-injury in experimental model. In clinical settings, severe head injury patients, who are often complicated with respiratory or urinary infection and with bacterial translocation, can suffer not only from systemic inflammatory responses originated from the brain but also from septic encephalopathy mentioned above. Therefore multiply traumatized patients with damaged brain for instance might well have to be considered as the aggregation, or integration of the systemic insult from the aspect of aggressology.
authors.affiliation: Department of Emergency and Critical Care Medicine, Showa University School of Medicine, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Aruga
mesh_terms: D001927:Brain Diseases / Q000503:physiopathology; D001930:Brain Injuries / Q000503:physiopathology; D016207:Cytokines / Q000502:physiology; D006801:Humans; D009422:Nervous System Diseases / Q000503:physiopathology*; D018805:Sepsis / Q000503:physiopathology; D013312:Stress, Physiological / Q000503:physiopathology*; D013514:Surgical Procedures, Operative; D018746:Systemic Inflammatory Response Syndrome / Q000503:physiopathology*
chemical_list: D016207:Cytokines