title: Genesis of the frog retinal pigment epithelium.
abstract: To examine cell generation in the frog retinal pigment epithelium (RPE), representative developmental stages from tail-bud to adulthood received a single injection of [3H]thymidine. Animals were killed either 24 h or several weeks later; eyes were sectioned and processed by standard autoradiographic procedures and viewed by epi-polarised illumination. The distribution of [3H]thymidine-labelled cells indicated that the RPE is formed throughout life, including in adulthood, by cell addition at the ciliary margin, matching the pattern for the neural retina. In addition, a very small number of peripapillary RPE cells underwent division but only in the adult.
authors.affiliation: Department of Zoology, University of Western Australia, Nedlands, Australia.
authors.forename: L D
authors.initials: LD
authors.lastname: Beazley
authors.forename: M
authors.initials: M
authors.lastname: Tennant
authors.forename: T L
authors.initials: TL
authors.lastname: Tomlin
authors.forename: J M
authors.initials: JM
authors.lastname: Preuss
authors.forename: L A
authors.initials: LA
authors.lastname: Coleman
authors.forename: S A
authors.initials: SA
authors.lastname: Dunlop
mesh_terms: D000818:Animals; D001001:Anura / Q000196:embryology* / Q000254:growth & development; D001345:Autoradiography; D002452:Cell Count; D004625:Embryo, Nonmammalian / Q000502:physiology; D008675:Metamorphosis, Biological / Q000502:physiology*; D010857:Pigment Epithelium of Eye / Q000196:embryology* / Q000254:growth & development; D014982:Xenopus laevis / Q000196:embryology* / Q000254:growth & development