title: The early effect of specific immunotherapy on lymphocyte response to PHA and allergens in atopic patients with allergic rhinitis.
abstract: In the first part of this study, peripheral lymphocyte subpopulations and their proliferative response to PHA and allergens were investigated in the 30 patients with allergic rhinitis compared to 20 healthy non-atopic individuals. Data obtained employing a PHA-induced lymphoproliferative response assay revealed that the allergic rhinitis generated significantly less activity than did the normal control group. Significantly decreased ration of CD4+/CD8+ T cells was noted in the patients with allergic rhinitis. Mean values of stimulation indices by allergen extracts were higher in the patients sensitive to same antigen than others especially in concentration of 1000 SQU/ml. Stimulation of active lymphocytes revealed no statistically significant group differences between allergens. In the second part of the study, the early effect of immunotherapy on T cell subsets and lymphocyte proliferative response to PHA and allergens were examined in the peripheral blood lymphocytes of patients. A significant increase in PHA-induced and in allergen induced lymphoproliferative response were observed in all patients after sixth months of immunotherapy. It is concluded that there may be an association between allergic rhinitis and deficiency of circulating CD4+ cells but further studies are required to substantiate this hypothesis.
authors.affiliation: Department of Immunology, Ankara University School of Medicine, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Kinikli
authors.forename: N
authors.initials: N
authors.lastname: Tülek
authors.forename: T
authors.initials: T
authors.lastname: Sentürk
authors.forename: M
authors.initials: M
authors.lastname: Turgay
authors.forename: H
authors.initials: H
authors.lastname: Tutkak
authors.forename: M
authors.initials: M
authors.lastname: Duman
authors.forename: G
authors.initials: G
authors.lastname: Tokgöz
mesh_terms: D000328:Adult; D000485:Allergens / Q000276:immunology / Q000494:pharmacology / Q000627:therapeutic use*; D000946:Antigens, Fungal / Q000276:immunology; D016516:CD4-CD8 Ratio; D002478:Cells, Cultured; D003888:Desensitization, Immunologic; D004391:Dust; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000150:complications / Q000276:immunology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D010835:Phytohemagglutinins / Q000494:pharmacology*; D037121:Plant Lectins; D011058:Pollen / Q000276:immunology; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology / Q000628:therapy*; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000485:Allergens; D000946:Antigens, Fungal; D004391:Dust; D010835:Phytohemagglutinins; D037121:Plant Lectins