title: Margination and diapedesis of inflammatory cells in the islets of Langerhans in hamsters infected with the 139H strain of scrapie.
abstract: The islets of Langerhans in hamsters infected with the 139H strain of scrapie contain large masses of red blood cells not surrounded by the usual arterial, venous or capillary wall cells. We have referred to these structures as "blood vessel cores" (BVCs). BVCs were almost always centrally located within the islets and surrounded by pancreatic B cells. Margination and diapedesis of inflammatory cells were observed at the BVC walls in 139H-infected hamsters. The cells consisted of the following types: single or clustered lymphocytes; and mixtures of lymphocytes and macrophages or neutrophils. Interaction observed between groups of inflammatory cells and B cells at the BVC walls and inside the islets of Langerhans indicated an inflammatory process. We refer to this interaction as the "linkage-reaction", and to the inflammatory cells as "linkage-inflammatory cells". These phenomena were not observed in other organs (adrenal, uterus, ovary, spleen, liver, kidney, oesophagus, trachea, intestine or pituitary) in 139H-affected hamsters or in the islets of Langerhans of animals infected with other scrapie strains (263K-infected hamsters; 139A-, ME7- and 22L-infected SJL mice). This appears to represent the first clear evidence of an inflammatory reaction in any organ in scrapie-infected animals.
authors.affiliation: New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA.
authors.forename: X
authors.initials: X
authors.lastname: Ye
authors.forename: R I
authors.initials: RI
authors.lastname: Carp
mesh_terms: D000818:Animals; D002465:Cell Movement; D006224:Cricetinae; D005260:Female; D007249:Inflammation / Q000473:pathology / Q000821:virology; D007515:Islets of Langerhans / Q000473:pathology* / Q000821:virology; D007962:Leukocytes / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008815:Mice, Inbred Strains; D011328:Prions / Q000472:pathogenicity*; D012608:Scrapie / Q000209:etiology / Q000473:pathology*
chemical_list: D011328:Prions