[Diagnosis and surgical treatment of distal congenital intestinal aganglionosis in children].
The article contains the analysis of the additional diagnostic methods in children with Hirschsprung's disease. The main role belongs to the histobiochemical investigation of the rectal mucosa that can help to estimate acetylcholinesterase activity for the diagnosis of distal aganglionosis. The results of 100 biopsies in 93 children with chronic obstipation were examined. The analysis helped to find correlation between chronic constipation and activity of acetyicholinesterase. The use of hystobiochemical method helped to determine the distal form of congenital aganglionosis in 20 children. 10 patients had surgery with good results in short-term postoperative period.
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D000110:Acetylcholinesterase / Q000378:metabolism*; D000293:Adolescent; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D006627:Hirschsprung Disease / Q000175:diagnosis* / Q000201:enzymology / Q000601:surgery*; D006801:Humans; D007223:Infant; D007413:Intestinal Mucosa / Q000201:enzymology; D012007:Rectum
D000110:Acetylcholinesterase