title: Papillary thyroid carcinoma in three siblings with familial adenomatous polyposis.
abstract: The authors report three siblings (two sisters and their aunt, aged 20, 22 and 36, respectively) with familial adenomatous polyposis (FAP) and papillary thyroid carcinoma. After diagnosis of FAP, a single, non palpable nodule was revealed in each patient by routine screening ultrasonography of the gland. The diagnosis of papillary carcinoma was made by fine-needle-aspiration biopsy of the nodules and confirmed by histologic examination of surgical specimens. A review of the literature reveals about 40 reports of such an association, that is considered not fortuitous. Nevertheless, in this family the association seems to be a distinctive, clinical feature of the syndrome, affecting three out of five members intensively screened for extracolonic lesions.
authors.affiliation: Department of Surgery, University of Siena, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Civitelli
authors.forename: G
authors.initials: G
authors.lastname: Tanzini
authors.forename: F
authors.initials: F
authors.lastname: Cetta
authors.forename: M
authors.initials: M
authors.lastname: Petracci
authors.forename: M C
authors.initials: MC
authors.lastname: Pacchiarotti
authors.forename: B
authors.initials: B
authors.lastname: Civitelli
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000235:genetics / Q000473:pathology*; D000328:Adult; D001707:Biopsy, Needle; D002291:Carcinoma, Papillary / Q000235:genetics / Q000473:pathology*; D005192:Family Health; D005260:Female; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D010375:Pedigree; D013964:Thyroid Neoplasms / Q000235:genetics / Q000473:pathology*