Effect of population mixing and socioeconomic status in England and Wales, 1979-85, on lymphoblastic leukaemia in children.
OBJECTIVE
To examine the effects of migration, diversity of migrant origins, commuting, and socioeconomic status on the incidence of acute lymphoblastic leukaemia in childhood.


METHODS
Poisson regression analysis of incidence rates in relation to the variables of interest.


METHODS
The 403 county districts of England and Wales during 1979-85.


METHODS
Children aged under 15 years.


RESULTS
There were significant trends in the incidence of lymphoblastic leukaemia at ages 0-4 and 5-9 years with the proportion of children in a district who had recently entered the district. While there was no consistent relation between the proportion of recent incomers in the total population of a district and its incidence rate, the combination of higher migration with greater diversity of origins or distance moved was associated with higher incidence in both age groups. Incidence increased significantly at age 0-4 with the level of employment in a district and at age 5-9 with the proportion of households with access to a car. No significant trends were found with commuting.


CONCLUSIONS
The results for level of child migration and diversity of total migration provide evidence of an effect of population mixing on the incidence of childhood leukaemia which is not restricted to areas experiencing the most extreme levels of mixing.
Stiller
C A
CA
Childhood Cancer Research Group, University of Oxford.
Boyle
P J
PJ
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003710:Demography; D004739:England / Q000453:epidemiology; D006306:Health Surveys; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D015999:Multivariate Analysis; D016012:Poisson Distribution; D011157:Population Dynamics; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology*; D012959:Socioeconomic Factors; D014171:Transients and Migrants / Q000706:statistics & numerical data*; D014195:Travel; D014852:Wales / Q000453:epidemiology