[The problem of recurrence of rhino-sinusal polyposis: pilot trial with locally administered azelastine HCL in the prevention of relapses].
Recurrent nasal polyposis is one of the most common unsolved problem in clinical rhinology. In the last few years a great number of histopathological, immunohistochemical and immunological studies on nasal polyps have been carried out by several Authors. Notwithstanding this, the aetiology of these formations still remains unknown. Many data suggest that the presence of polyps is the result of various inflammatory, allergic and pseudo-allergic processes which finally lead to the formation of the oedema constitutive of the polyp itself. In the present report a preliminary trial was carried out in order to evaluate the possibility of preventing recurrences by means of a locally administered anti-H1 receptors drug (Azelastine HCl). In the reported first phase of the study 10 allergic patients with bilateral polyposis were evaluated. Attention was given to the anti-edemigen activity of the drug, as well as to its influence on the local production of Secretory IgA, 7SIgA and albumines. Data are presented and discussed.
Bussi
M
M
Il Clinica ORL, Università di Torino.
Carlevato
M T
MT
Majore
L
L
Battaglio
S
S
Napoli
P
P
Cortesina
G
G
D000418:Albumins / Q000378:metabolism; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D007070:Immunoglobulin A / Q000187:drug effects; D009298:Nasal Polyps / Q000188:drug therapy* / Q000601:surgery*; D010793:Phthalazines / Q000494:pharmacology / Q000627:therapeutic use*; D010865:Pilot Projects; D012008:Recurrence
D000418:Albumins; D006634:Histamine H1 Antagonists; D007070:Immunoglobulin A; D010793:Phthalazines; C020976:azelastine