Cardiac and skeletal muscle scintigraphy in dermato- and polymyositis: clinical implications.
To determine the role of scintigraphy in the detection of skeletal and cardiac involvement in dermato- and polymyositis (DM/PM), we studied 30 patients with a confirmed diagnosis of DM/PM (23 females, 7 males; mean age: 35 years). Technetium-99m pyrophosphate (99mTc-PYP) and gallium-67 scans showed similar sensitivity, specificity and accuracy in the detection of skeletal muscle involvement when compared with serum enzymes (70%, 100% and 80%, respectively). Compared with the clinical parameters, 99mTc-PYP showed 70% and 67Ga 65% accuracy. Abnormal PYP cardiac uptake was observed in 57% of patients, whereas abnormal 67Ga cardiac uptake was seen in only 15%. Electrocardiography was abnormal in 40%, rest gated blood pool study in 23%, and chest X-ray in 13%. In conclusion, both 99mTc-PYP and 67Ga can be useful in the detection of the active phase of muscle disease. However, 99mTc-PYP seems to be more effective than 67Ga in the early diagnosis of cardiac involvement.
Buchpiguel
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CA
Centro de Medicina Nuclear, Departamento de Radiologia, Faculdade de Medicina da USP, Cx Postal 11136, CEP 05422-970, São Paulo-SP, Brasil.
Roizemblatt
S
S
Pastor
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EH
Hironaka
F H
FH
Cossermelli
W
W
D000293:Adolescent; D000328:Adult; D002648:Child; D004796:Clinical Enzyme Tests; D003882:Dermatomyositis / Q000175:diagnosis / Q000000981:diagnostic imaging*; D004562:Electrocardiography; D005260:Female; D005710:Gallium Radioisotopes; D015637:Gated Blood-Pool Imaging; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging*; D017285:Polymyositis / Q000175:diagnosis / Q000000981:diagnostic imaging*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D016698:Technetium Tc 99m Pyrophosphate
D005710:Gallium Radioisotopes; D016698:Technetium Tc 99m Pyrophosphate