Ischemia-induced neuronal apoptosis.
Hypoxic-ischemic neuronal death has long been considered to represent necrosis, but it now appears that many brain neurons undergo apoptosis after either global or focal ischemic insults. This event is probably substantially distinct from ischemia-triggered excitotoxicity, which tends to produce necrosis. While many questions remain unanswered, the concept of ischemic apoptosis has raised exciting prospects of combining anti-apoptotic with anti-excitotoxic treatments to achieve heightened therapeutic benefits in the brains of patients traumatized by cardiac arrest or stroke.
Choi
D W
DW
Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, Missouri 63110-1093, USA.
D000818:Animals; D017209:Apoptosis; D001921:Brain / Q000166:cytology* / Q000473:pathology / Q000502:physiology*; D002545:Brain Ischemia / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D002561:Cerebrovascular Disorders / Q000628:therapy; D006323:Heart Arrest / Q000628:therapy; D006801:Humans; D002534:Hypoxia, Brain / Q000473:pathology / Q000503:physiopathology*; D002546:Ischemic Attack, Transient / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D009336:Necrosis; D009410:Nerve Degeneration; D009474:Neurons / Q000166:cytology / Q000473:pathology / Q000502:physiology*