[Local intra-arterial thrombolysis in acute ischemia of an extremity].
The effect of intra-arterial local thrombolysis or peripheral arterial occlusions seems to be well documented. As assessed by angiography, primary recanalisation is achieved in 65-90%. Using recombinant tissue plasminogen activator thrombolysis is achieved more frequently (90% vs 65-85%) and faster (4-8 hours vs 12-48 hours) than when using streptokinase or urokinase. The most frequently used dosages are streptokinase 5000 IU/h, and recombinant tissue plasminogen activator 0.5 mg/h. So far, results from randomized trials between thrombolytic therapy and surgery have not been published.
Enevoldsen
M T
MT
Karkirurgisk afdeling RK, Rigshospitalet, København.
Rørdam
P
P
Schroeder
T V
TV
D000208:Acute Disease; D001157:Arterial Occlusive Diseases / Q000188:drug therapy* / Q000517:prevention & control; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D007269:Injections, Intra-Arterial; D007511:Ischemia / Q000188:drug therapy; D007866:Leg / Q000098:blood supply; D010960:Plasminogen Activators / Q000008:administration & dosage*; D015912:Thrombolytic Therapy / Q000379:methods*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*
D005343:Fibrinolytic Agents; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator