title: Very high-dose streptomycin labyrinthectomy.
abstract: Medical labyrinthectomy by systemic administration of streptomycin has proven safe and effective for treatment of selected patients with intractable vertigo. In most patients, 40 grams or less of streptomycin sulfate are required. However, otolaryngologists should be aware that much higher doses can be used safely in selected patients; and a small number of patients may be resistant to streptomycin toxicity even in doses over 100 grams.
authors.affiliation: Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
authors.forename: R T
authors.initials: RT
authors.lastname: Sataloff
authors.forename: A
authors.initials: A
authors.lastname: McCarter
authors.forename: J R
authors.initials: JR
authors.lastname: Spiegel
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents; D004305:Dose-Response Relationship, Drug; D007758:Ear, Inner / Q000187:drug effects*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D013307:Streptomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014717:Vertigo / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000900:Anti-Bacterial Agents; D013307:Streptomycin