title: Photochemical stability of norfloxacin in solutions, bulk form and tablets.
abstract: Accelerated photochemical degradation of norfloxacin in solutions, bulk forms, and tablets has been undertaken. The kinetic order of the drug photodegradation was determined by monitoring residual drug masses as a function of time matched with initial matched mass by adopting the HPLC-method of USP-23. A new dimeric photodegradate, formed from the active decarboxylated norfloxacin monomer, could be isolated and characterized.
authors.affiliation: Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
authors.forename: O A
authors.initials: OA
authors.lastname: al-Deeb
authors.forename: E M
authors.initials: EM
authors.lastname: Abdel-Moety
authors.forename: M A
authors.initials: MA
authors.lastname: Abounassif
authors.forename: S R
authors.initials: SR
authors.lastname: Alzaben
mesh_terms: D000890:Anti-Infective Agents / Q000032:analysis*; D004355:Drug Stability; D009643:Norfloxacin / Q000032:analysis*; D010777:Photochemistry; D013607:Tablets
chemical_list: D000890:Anti-Infective Agents; D013607:Tablets; D009643:Norfloxacin