Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction.
The human cytomegalovirus genome encodes proteins that trigger destruction of newly synthesized major histocompatibility complex (MHC) class I molecules. The human cytomegalovirus gene US2 specifies a product capable of dislocating MHC class I molecules from the endoplasmic reticulum to the cytosol and delivering them to the proteasome. This process involves the Sec61 complex, in what appears to be a reversal of the reaction by which it translocates nascent chains into the endoplasmic reticulum.
Wiertz
E J
EJ
Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.
Tortorella
D
D
Bogyo
M
M
Yu
J
J
Mothes
W
W
Jones
T R
TR
Rapoport
T A
TA
Ploegh
H L
HL
D000255:Adenosine Triphosphate / Q000378:metabolism; D001693:Biological Transport, Active; D002460:Cell Line; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D003587:Cytomegalovirus / Q000276:immunology; D003600:Cytosol / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006031:Glycosylation; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D009097:Multienzyme Complexes / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex; D017510:Protein Folding; D000069816:SEC Translocation Channels; D014764:Viral Proteins / Q000276:immunology
D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins; D009097:Multienzyme Complexes; D000069816:SEC Translocation Channels; D014764:Viral Proteins; D000255:Adenosine Triphosphate; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex