Genesis of the frog retinal pigment epithelium.
To examine cell generation in the frog retinal pigment epithelium (RPE), representative developmental stages from tail-bud to adulthood received a single injection of [3H]thymidine. Animals were killed either 24 h or several weeks later; eyes were sectioned and processed by standard autoradiographic procedures and viewed by epi-polarised illumination. The distribution of [3H]thymidine-labelled cells indicated that the RPE is formed throughout life, including in adulthood, by cell addition at the ciliary margin, matching the pattern for the neural retina. In addition, a very small number of peripapillary RPE cells underwent division but only in the adult.
Beazley
L D
LD
Department of Zoology, University of Western Australia, Nedlands, Australia.
Tennant
M
M
Tomlin
T L
TL
Preuss
J M
JM
Coleman
L A
LA
Dunlop
S A
SA
D000818:Animals; D001001:Anura / Q000196:embryology* / Q000254:growth & development; D001345:Autoradiography; D002452:Cell Count; D004625:Embryo, Nonmammalian / Q000502:physiology; D008675:Metamorphosis, Biological / Q000502:physiology*; D010857:Pigment Epithelium of Eye / Q000196:embryology* / Q000254:growth & development; D014982:Xenopus laevis / Q000196:embryology* / Q000254:growth & development