Sclerotiamide: a new member of the paraherquamide class with potent antiinsectan activity from the sclerotia of Aspergillus sclerotiorum.
Sclerotiamide (1), a new fungal natural product related to the paraherquamides, was isolated by bioassay-guided fractionation of antiinsectan organic extracts from the sclerotia of Aspergillus sclerotiorum (NRRL 5167). The structure was determined primarily through 1H-NMR, 13C-NMR, HMQC, and HMBC experiments. Sclerotiamide causes significant mortality and unusual physiological effects in dietary assays against the corn earworm Helicoverpa zea.
Whyte
A C
AC
Department of Chemistry, University of Iowa, Iowa City 52242, USA.
Gloer
J B
JB
Wicklow
D T
DT
Dowdw
P F
PF
D000818:Animals; D001230:Aspergillus / Q000737:chemistry*; D001517:Coleoptera / Q000502:physiology*; D018360:Crystallography, X-Ray; D003864:Depression, Chemical; D004354:Drug Screening Assays, Antitumor; D005247:Feeding Behavior / Q000187:drug effects; D007212:Indolizines / Q000302:isolation & purification* / Q000494:pharmacology; D007306:Insecticides / Q000302:isolation & purification* / Q000494:pharmacology; D007814:Larva; D009682:Magnetic Resonance Spectroscopy; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013141:Spiro Compounds / Q000302:isolation & purification* / Q000494:pharmacology
D007212:Indolizines; D007306:Insecticides; D013141:Spiro Compounds; C103459:sclerotiamide