title: [Successful treatment of fetal supraventricular tachycardia with a combination of digoxin and amiodarone].
abstract: The supraventricular tachycardia is a life threatening state in the intrauterine life. It can cause non-immune hydrops fetalis, intrauterine death or complications during the delivery. The unexplained tachycardia can cause fetal distress and premature delivery. Usually the digoxin is the first drug of choice for transplacental cardioversion. If digitalisation does not achieve cardioversion, the second line antiarrhythmic drugs should be instituted. Amiodarone has been suggested as a therapeutic alternative after failure of digoxin-verapamil combination. We give a drug in standard therapeutic doses for four-five days and after it we determine whether it is effective or not. We should determine the newer therapy or termination of pregnancy. The transplacental administration of amiodarone may be dangerous because of fetal cretinism. Our case is the first in Hungary-in our best knowledge- and we suggest the amiodarone for transplacental therapy.
authors.affiliation: Semmelweis Orvostudományi Egyetem I. Szülészeti és Nógyógyászati Klinika, Budapest.
authors.forename: J
authors.initials: J
authors.lastname: Hajdú
authors.forename: I
authors.initials: I
authors.lastname: Szabó
authors.forename: J
authors.initials: J
authors.lastname: Német
mesh_terms: D000328:Adult; D000638:Amiodarone / Q000008:administration & dosage*; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D004077:Digoxin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D005313:Fetal Death / Q000517:prevention & control; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D006814:Hungary; D011247:Pregnancy; D013617:Tachycardia, Supraventricular / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000196:embryology*; D016216:Ultrasonography, Prenatal
chemical_list: D000889:Anti-Arrhythmia Agents; D004077:Digoxin; D000638:Amiodarone