Localization of the human phosphotyrosine phosphatase-related genes (h-PRL-1) to chromosome bands 1p35-p34, 17q12-q21, 11q24-q25 and 12q24.
The h-PRL-1 gene codes for a new phosphotyrosine phosphatase that may play an important role in the control of basic cellular processes such as cell growth and proliferation. Using the cDNA of the h-PRL-1 gene as a probe, we examined a somatic mouse and hamster x human hybrid panel and found that chromosomes 1, 17 and 11 harbor sequences homologous to h-PRL-1. By in situ hybridization of metaphase spreads, subchromosomal localizations were determined at bands 1p35-p34, 17q12-q21 and 11q24-q25; in addition, a faint signal was detected at 12q24. The chromosomal assignment of the genes homologous to h-PRL-1 will help the investigation of its possible involvement in human diseases involving genetic alteration at these chromosomal regions.
Montagna
M
M
International Agency for Research on Cancer, Lyon, France.
Serova
O
O
Sylla
B S
BS
Mattei
M G
MG
Lenoir
G M
GM
D000818:Animals; D018797:Cell Cycle Proteins; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D002881:Chromosomes, Human, Pair 12; D002886:Chromosomes, Human, Pair 17; D006224:Cricetinae; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics*; D008565:Membrane Proteins; D051379:Mice; D009363:Neoplasm Proteins; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*
D018797:Cell Cycle Proteins; D017874:Immediate-Early Proteins; D008565:Membrane Proteins; D009363:Neoplasm Proteins; C490198:PTP4A1 protein, human; D017027:Protein Tyrosine Phosphatases; C087359:Ptp4a1 protein, mouse