title: [Gene analysis of acid proteases].
abstract: We described gene analysis of acid proteinases, cathepsin E (CTSE), pepsinogen A (PGA), and pepsinogen C (PGC), and demonstrated the clinical significance of these genes. CTSE was highly expressed in pancreatic cancer and can be a tumor marker for pancreatic cancer. PGC gene polymorphism was associated with gastric ulcer and can be a subclinical marker of the genetic predisposition to gastric ulcer.
authors.affiliation: Second Department of Internal Medicine, Fukui Medical School.
authors.forename: T
authors.initials: T
authors.lastname: Azuma
mesh_terms: D000595:Amino Acid Sequence; D016282:Aspartic Acid Endopeptidases / Q000235:genetics*; D001483:Base Sequence; D015415:Biomarkers; D020059:Cathepsin E; D002403:Cathepsins / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D010190:Pancreatic Neoplasms / Q000175:diagnosis; D010435:Pepsinogens / Q000235:genetics*; D011110:Polymorphism, Genetic; D013276:Stomach Ulcer / Q000175:diagnosis
chemical_list: D015415:Biomarkers; D010435:Pepsinogens; D002403:Cathepsins; D016282:Aspartic Acid Endopeptidases; D020059:Cathepsin E