Circulating immune complexes and renal function in canine leishmaniasis.
A third component of complement (C3) capture enzyme-linked immunosorbent assay was used to determine the concentration of IgG circulating immune complexes (CIC) in 91 dogs with naturally acquired leishmania infection and in a control group of 24 healthy dogs. Results were expressed as a percentage of a reference standard. Mean concentrations of CIC were significantly (P < 0.001) higher in leishmania-infected dogs (228.725 +/- 14.283%) than in controls (74.542 +/- 12.614%). An increase in CIC concentration was found in 57.1% of the leishmania-infected dogs. No significant differences could be recorded in CIC levels between males and females in either group. Infected dogs showing hypercreatininemia rendered a statistically significant (P < 0.030) higher serum CIC concentration than sick dogs with normal creatininemia. When hypercreatininemia (> or = 1.30 mg/dl) was used as an indicator for CIC increase, the positive predictive value obtained was 0.9 indicating that renal function impairment was associated with high serum CIC concentration in 90% of the infected dogs.
Lopez
R
R
Department of Veterinary Clinical Pathology, Faculty of Veterinary of Córdoba, Spain.
Lucena
R
R
Novales
M
M
Ginel
P J
PJ
Martin
E
E
Molleda
J M
JM
D000818:Animals; D000936:Antigen-Antibody Complex / Q000097:blood* / Q000502:physiology; D015932:Complement C3c; D003404:Creatinine / Q000097:blood; D004283:Dog Diseases / Q000097:blood / Q000276:immunology* / Q000503:physiopathology*; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D007074:Immunoglobulin G / Q000097:blood; D007668:Kidney / Q000503:physiopathology*; D007896:Leishmaniasis / Q000276:immunology / Q000503:physiopathology / Q000662:veterinary*; D008297:Male; D011237:Predictive Value of Tests
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D015932:Complement C3c; D003404:Creatinine