Is there a causal connection between bile acids and colorectal cancer?
Bile acid composition was assessed in 50 patients with colorectal cancer as compared to that in a control group of 50 subjects. The two groups were age- and sex-matched. The overall bile acid values were similar in both groups, while the relative concentrations of primary and secondary bile acids were different, a significant increase in the patients with colorectal cancer being observed. This finding thus seems to confirm the existence of a link between colorectal cancer and cholelithiasis. Both conditions share common risk factors, such as alterations in cholesterol metabolism and bile acid composition.
Tocchi
A
A
First Department of Surgery, University of Rome "La Sapienza," Viale del Policlinico, Italy.
Basso
L
L
Costa
G
G
Lepre
L
L
Liotta
G
G
Mazzoni
G
G
Sita
A
A
Tagliacozzo
S
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001647:Bile Acids and Salts / Q000502:physiology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002769:Cholelithiasis / Q000503:physiopathology*; D015179:Colorectal Neoplasms / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012307:Risk Factors
D001647:Bile Acids and Salts