[Manifestation of nasal allergy in ovalbumin-sensitized mice--as compared with mast cell-deficient mice, determined with an immunosuppressive agent].
We performed general and topical sensitization by ovalbumin in wild type, WBBFI6- +/+ (+/+), mice and mast cell-depleted type, WBBFI6-W/Wv (W/W)v, mice. Although both mice showed almost equal PCA liters, W/Wv mice showed a lower level of antigen-induced eosinophilia, and more significant nasal symptoms and histamine hypersensitivity than +/+ mice. Antigen-induced increased levels of histamine and IL-5 in nasal lavage fluid were noted in +/+ mice. Cyclosporin A pre-treatment inhibited the antigen-induced nasal symptoms, nasal eosinophilia and increased levels of histamine and IL-5 in nasal lavage fluid in the +/+ mice. The PCA titer was not affected by the treatment in either kind of mouse.
Watanabe
M
M
Department of Otolaryngology, Sapporo Medical University School of Medicine.
Asakura
K
K
Saito
H
H
Kataura
A
A
D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology*; D007114:Immunization; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008297:Male; D008407:Mast Cells / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D010047:Ovalbumin / Q000276:immunology*; D010323:Passive Cutaneous Anaphylaxis; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology*
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D010047:Ovalbumin