title: [An operative case of cholesterol granuloma of the petrous apex].
abstract: A 59-year-old man presented with a rare cholesterol granuloma of the petrous apex manifesting as headache, left facial dysesthesia, diplopia, left hearing impairment, and left tinnitus. Neurological examination revealed dysesthesia of territory in all divisions of the left trigeminal nerve, left incomplete abducens nerve palsy, left mixed hearing impairment, and left tinnitus. Plain CT scan showed a smoothly marginated mass involving the left petrous apex. The mass was isodense with the brain parenchyma and not enhanced by contrast medium. The mass appeared heterogeneously slightly hyperintense on the T1-weighted MR image and homogeneously hyperintense on the T2-weighted MR image except for the peripheral portion. The mass was not enhanced after intravenous gadolinium DTPA administration. Surgery via a petrosal approach totally removed the mass in the intracranial, extradural space. Histological examination showed typical features of cholesterol granuloma, with cholesterin clefts, hemosiderin deposits, and erythrocytes in non-specific granulation tissue. Cholesterol granuloma most commonly occurs in the middle ear cavity, and rarely in the petrous apex. The characteristic hyperintense appearance of cholesterol granuloma on T1- and T2-weighted MR images is very useful for differentiation from other lesions of the petrous apex and the cerebellopontine angle such as cholesteatoma, mucocele, chordoma, and meningioma. Solid cholesterol granuloma of the petrous apex should be treated by total removal via craniotomy, not by drainage which is commonly performed by otorhinologists.
authors.affiliation: Department of Surgical Neurology, Yamagata University School of Medicine.
authors.forename: M
authors.initials: M
authors.lastname: Saino
authors.forename: T
authors.initials: T
authors.lastname: Kayama
authors.forename: A
authors.initials: A
authors.lastname: Kuroki
authors.forename: Y
authors.initials: Y
authors.lastname: Siraisi
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: O
authors.initials: O
authors.lastname: Nakai
mesh_terms: D001847:Bone Diseases / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D002533:Cerebral Angiography; D002784:Cholesterol; D003399:Craniotomy; D015745:Granuloma, Foreign-Body / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010579:Petrous Bone; D014057:Tomography, X-Ray Computed
chemical_list: D002784:Cholesterol