An herbal prescription, S-113m, consisting of biota, ginseng and schizandra, improves learning performance in senescence accelerated mouse.
The effect of an herbal prescription, S-113m, consisting of biota, ginseng and schizandra, on learning and memory performance was studied in the senescence accelerated mouse (SAM). A solid diet containing 1% (w/w) S-113m was given to SAM from 1 month of age. A behavioral experiment, started 4 or 9 months later, revealed prominent learning impairment in SAMP8, a senescence accelerated-prone mouse. Chronic ingestion of S-113m improved the memory retention disorder of SAMP8 in a passive avoidance test and increased the conditioned avoidance rate in a lever-press test at the age of 10 months. The preparation also facilitated the memory retention deficit in the passive avoidance test in 10-month-old SAMR1, a senescent resistant substrain. These results raise the possibility that S-113m might be useful for treating physiological aging and age-related memory deficits in human.
Nishiyama
N
N
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Chu
P J
PJ
Saito
H
H
D000375:Aging / Q000235:genetics / Q000523:psychology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects; D005894:Panax / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry
D004365:Drugs, Chinese Herbal; C098440:S 113m