Issues in genetic testing for susceptibility to alcoholism: lessons from Alzheimer's disease and Huntington's disease.
Evidence from family, twin, and adoption studies suggest a heritable basis for alcoholism. However, alcoholism is likely to be genetically heterogeneous, and any genetic connection is likely to be in the form of genes conferring an increased risk or susceptibility. In this study, we present the evidence for a genetic component for alcoholism, and examine the precedent for genetic testing and screening for genetic susceptibility using Huntington's disease and Alzheimer's disease as examples. Finally, we discuss the preparations that need to be made before taking any findings about the genetics of alcoholism from the research laboratory into the clinic.
Quaid
K A
KA
Department of Medical and Molecular Genetics, Indiana University, School of Medicine, Indianapolis 46202-5251, USA.
Dinwiddie
H
H
Conneally
P M
PM
Nurnberger
J I
JI
D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000235:genetics*; D000544:Alzheimer Disease / Q000235:genetics*; D004992:Ethics, Medical; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D006816:Huntington Disease / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D005819:Genetic Markers