title: Hypo-osmolar sucrose oral rehydration solutions in acute diarrhoea: a pilot study.
abstract: Based on studies showing improved absorption of hypo-osmolar oral rehydration solutions (ORS) with reduced glucose and sodium concentration, a hypo-osmolar ORS with sucrose replacing glucose (sodium 60, potassium 15, chloride 60, citrate 5, sucrose 58 mmol l-1, calculated osmolality 198 mOsm kg-1) was compared with mildly hyperosmolar glucose ORS (WHO) in 46 children aged 6-30 months with acute diarrhoea and dehydration. In the hypo-osmolar sucrose ORS group (n = 18) faecal output was less by 30% during the initial 24 and 48 h compared with controls, suggesting better absorption. Sucrose may be a suitable alternative to glucose in an absorption-efficient hypo-osmolar ORS.
authors.affiliation: International Centre for Diarrhoeal Disease Research, Bangladesh.
authors.forename: A S
authors.initials: AS
authors.lastname: Faruque
authors.forename: D
authors.initials: D
authors.lastname: Mahalanabis
authors.forename: J
authors.initials: J
authors.lastname: Hamadani
authors.forename: S S
authors.initials: SS
authors.lastname: Hoque
mesh_terms: D000208:Acute Disease; D002675:Child, Preschool; D003968:Diarrhea, Infantile / Q000628:therapy*; D005440:Fluid Therapy; D006801:Humans; D007223:Infant; D009994:Osmolar Concentration; D010865:Pilot Projects; D015532:Rehydration Solutions; D013395:Sucrose / Q000008:administration & dosage* / Q000378:metabolism
chemical_list: D015532:Rehydration Solutions; D013395:Sucrose