Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior.
Two new lignans, interiotherins A (1) and B (2), along with two known lignans, angeloylgomisin R (3) and schisantherin D (4), were isolated from Kadsura interior. Their structures and stereochemistries were determined from spectral data. Compounds 1 and 4 inhibit HIV replication with EC50 values of 3.1 and 0.5 micrograms/mL, respectively.
Chen
D F
DF
Department of Pharmacognosy, School of Pharmacy, Shanghai Medical University, People's Republic of China.
Zhang
S X
SX
Chen
K
K
Zhou
B N
BN
Wang
P
P
Cosentino
L M
LM
Lee
K H
KH
D019380:Anti-HIV Agents / Q000302:isolation & purification* / Q000494:pharmacology; D034242:Cyclooctanes; D004149:Dioxoles / Q000302:isolation & purification / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D017705:Lignans / Q000302:isolation & purification* / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects / Q000821:virology; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010936:Plant Extracts / Q000032:analysis; D018547:Plant Stems / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D034242:Cyclooctanes; D004149:Dioxoles; D017705:Lignans; D010936:Plant Extracts; C103454:interiotherin A; C103455:interiotherin B; C082093:schisantherin D