Antimicrobial efficacy of quaternary bisammonium salts and the effect of their sub-MICs on Pseudomonas aeruginosa virulence factors.
Antipseudomonadal activity of homologous series of six quaternary bisammonium salts (QBAS) (4,7-dioxo-3,8-dioxadekan-1,1-[bis(alkyldimethyldiammonium dibromide)] as well as the effect of their subinhibitory concentrations (sub-MICs) on Pseudomonas aeruginosa virulence factors was studied. Antibacterial activity of QBAS increased up to a certain length of the chain and then decreased with further elongation. All the tested sub-MICs of QBAS caused a significant suppression of phospholipase C activity (to 0-41%). Elastase and proteinase activity were less efficiently reduced. A more effective decrease of these activities was only found after treatment with one-fourth of the MICs of the tested substances. QBAS caused only an erratic decrease of alginate production.
Hostacká
A
A
Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
Majtán
V
V
Hybenová
D
D
D000464:Alginates / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000378:metabolism / Q000472:pathogenicity; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000494:pharmacology*; D010738:Type C Phospholipases / Q000037:antagonists & inhibitors; D014774:Virulence / Q000187:drug effects
D000464:Alginates; D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D006603:Hexuronic Acids; D011480:Protease Inhibitors; D000644:Quaternary Ammonium Compounds; D020723:Glucuronic Acid; D010738:Type C Phospholipases; D010196:Pancreatic Elastase