title: [Obesity as the first manifestation of central nervous system involvement in acute lymphoblastic leukemia].
abstract: Obesity due to leukemic involvement of the hypothalamus may be the first manifestation of central nervous system (CNS) relapse. Hypothalamic syndrome may precede the appearance of lymphoblasts in the cerebrospinal fluid by a few months. We report a case of an 8-year-old girl with acute lymphoblastic leukemia who developed obesity, which was the first symptom of CNS relapse. A second remission and weight loss was achieved after intensive treatment.
authors.affiliation: Oddzial Hematologii Onkologicznej Slaskiego Centrum Pediatrii w Zabrzu.
authors.forename: R
authors.initials: R
authors.lastname: Tomaszewska
authors.forename: M
authors.initials: M
authors.lastname: Wieczorek
authors.forename: A
authors.initials: A
authors.lastname: Hicke
authors.forename: D
authors.initials: D
authors.lastname: Sońta-Jakimczyk
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D015992:Body Mass Index; D002648:Child; D003131:Combined Modality Therapy; D003561:Cytarabine / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000627:therapeutic use; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use; D009765:Obesity / Q000209:etiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D011829:Radiation Dosage; D012008:Recurrence
chemical_list: D000970:Antineoplastic Agents; D003561:Cytarabine; D006854:Hydrocortisone; D008727:Methotrexate