Exercise-induced changes in neuropeptide Y, noradrenaline and endothelin-1 levels in young people with type I diabetes.
In search of early signs of autonomic and vascular dysfunction in diabetic subjects, six young men with type I diabetes and six healthy subjects were investigated regarding arterial levels of noradrenaline (NA), neuropeptide Y- (NPY) and endothelin-1-(ET-1) like immunoreactivity (Li) during and after 1 h of exercise at 70% of peak oxygen uptake. Basal NA, NPY-Li and ET-1-Li levels did not differ between groups. NA and NPY-Li rose during exercise in diabetic subjects to only 60% of the control values (P < 0.05, interaction group x time P < 0.001). Disappearance rates for NA and NPY-Li did not differ between groups. Plasma ET-1-Li did not differ between groups during exercise. Values returned to basal levels within 5 min in the diabetic but not in the control group. In conclusion, diabetic subjects show lower NPY-Li and NA levels than control subjects during exercise but similar disappearance rates after exercise, indicating lower releases. Furthermore, plasma ET-1 levels did not differ between groups during exercise.
Ahlborg
G
G
Department of Clinical Physiology, Huddinge University Hospital, Stockholm, Sweden.
Lundberg
J M
JM
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000503:physiopathology; D019332:Endothelin-1 / Q000097:blood*; D004734:Energy Metabolism / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005990:Glycerol / Q000097:blood; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008297:Male; D009478:Neuropeptide Y / Q000097:blood*; D009638:Norepinephrine / Q000097:blood*; D016683:Supine Position / Q000502:physiology
D001786:Blood Glucose; D019332:Endothelin-1; D009478:Neuropeptide Y; D019344:Lactic Acid; D005990:Glycerol; D009638:Norepinephrine