Type I second-degree AV block after neostigmine administration in a child with renal failure.
Neostigmine is commonly used to reverse neuromuscular blockade. A side effect can be parasympathetic stimulation, which may result in heart block. Renal failure can decrease the clearance and increase the half-life of the drug, thus increasing the likelihood of a vagomimetic response. A case is presented where a child with renal failure developed a type I second-degree heart block after neostigmine was given.
Webb
M D
MD
Department of Pediatric Dentistry, Baylor College of Dentistry, Dallas, Texas 75246, USA.
D001283:Atrioventricular Node / Q000187:drug effects; D002648:Child; D000075202:Contraindications; D017742:Dental Care for Chronically Ill; D005260:Female; D006327:Heart Block / Q000139:chemically induced*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D009388:Neostigmine / Q000009:adverse effects*; D009466:Neuromuscular Blocking Agents; D010277:Parasympathomimetics / Q000009:adverse effects*
D009466:Neuromuscular Blocking Agents; D010277:Parasympathomimetics; D009388:Neostigmine