title: Tryptophan restriction causes long-term plastic changes in corticofrontal pyramidal neurons.
abstract: A Golgi study of third-layer pyramidal neurons from the corticofrontal cortex of tryptophan-restricted rats was carried out. At 40 days of age, dendritic arborization from treated rats was less profuse than that seen in control rats, and enlargement of dendritic processes, as well as an increase of the number of dendritic spines, were observed in 60-day-old rats. These plastic responses could be mediated either by a decrease in serotonin, which acts on the serotoninergic receptors of pyramidal neurons, or through an indirect mechanism mediated by cortical interneurons, or by serotoninergic modulation of the activity of other cortical neurotransmitters such as acetylcholine. Also, it could represent compensatory mechanisms underlying behavioral performance in some paradigms related to several cognitive processes.
authors.affiliation: División de Patología Experimental, Centro de Investigación Biomédica de Occidente, IMSS, Guadalajara, Jal, México.
authors.forename: I
authors.initials: I
authors.lastname: González-Burgos
authors.forename: A R
authors.initials: AR
authors.lastname: del Angel-Meza
authors.forename: G
authors.initials: G
authors.lastname: Barajas-López
authors.forename: A
authors.initials: A
authors.lastname: Feria-Velasco
mesh_terms: D000818:Animals; D001835:Body Weight / Q000502:physiology; D003712:Dendrites / Q000502:physiology; D004032:Diet; D005260:Female; D009473:Neuronal Plasticity / Q000502:physiology*; D009929:Organ Size / Q000502:physiology; D017397:Prefrontal Cortex / Q000166:cytology* / Q000502:physiology*; D017966:Pyramidal Cells / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism; D014364:Tryptophan / Q000172:deficiency*
chemical_list: D012701:Serotonin; D014364:Tryptophan