title: Ki-67 expression in vulvar carcinoma. Preliminary results.
abstract: A proliferating cell nuclear antigen (Ki-67) expression was investigated in 73 cases of invasive vulvar cancer, to detect new diagnostic and prognostic factors. We individualized, like Hendriks (1994), two general patterns of reactivity: 1) diffused positivity in all tumoral tissue with a bad prognosis; 2) focal positivity, localized at the edge of tumoral aggregates. Moreover, within focal patterns, one group with positivity to MIB-l of 0.2-6% and another group of 7-9% with different prognoses (better in the first group). Histotype, lymph-nodal status, FIGO stage are strictly correlated with distribution of Ki-67; on the contrary, no correlation was found with grading and number of mitoses.
authors.affiliation: Institute of Gynaecology and Obstetrics, Padua University, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Marchetti
authors.forename: R
authors.initials: R
authors.lastname: Salmaso
authors.forename: S
authors.initials: S
authors.lastname: Polonio
authors.forename: D
authors.initials: D
authors.lastname: Perin
authors.forename: T
authors.initials: T
authors.lastname: Salviato
authors.forename: A
authors.initials: A
authors.lastname: Onnis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011379:Prognosis; D012680:Sensitivity and Specificity; D015996:Survival Rate; D014846:Vulvar Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology*
chemical_list: D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen