[Aspects of morphology of photodynamic destruction].
The results of light and electron microscopic study of the photodynamic destruction of the mouse liver with the use of Russian and imported photosensitizers (PS) at the concentration peak are presented. Considerable differences in the primary targets are noted; the changes correlated at the tissue and ultrastructural level. The use of two PS showed the damage of the soluble part of the cytoplasm: generalized cytoplasm damage with the involvement of main cell organelles in one case and the destruction of the sinusoidal lining and the hepatocyte sinusoidal pole with a diffuse spread of changes beyond the main focus of the damage close to the vascular bed in the other. Theoretical importance and practical application of the study are discussed.
Kats
V A
VA
Vorob'ev
S V
SV
Stebakova
L N
LN
Riazhskiĭ
G G
GG
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D003593:Cytoplasm / Q000187:drug effects / Q000473:pathology; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D015388:Organelles / Q000187:drug effects / Q000473:pathology; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000493:pharmacokinetics / Q000633:toxicity*; D017154:Stromal Cells / Q000187:drug effects / Q000473:pathology
D017319:Photosensitizing Agents