title: An outbreak of herpes rugbiorum managed by vaccination of players and sociosexual contacts.
abstract: An outbreak of herpes rugbiorum involved nine players including the scrum half and the full back. The infection was characterized by significant constitutional upset with decreased levels of general fitness and match performance for 1-4 months following the outbreak; one player had herpetic lesions on his right eyelid and corneum. Every infected player, 15 non-infected players and five sociosexual contacts received two vaccinations with intracellular subunit vaccine NFU. Ac. HSV-1 (S-MRC5). None of the players or contacts developed cutaneous herpetic recurrence during a follow-up period of 3 years; the player with ocular disease had one recurrence at 30 months following the original episode. These findings encourage consideration of prophylactic or post-exposure vaccination of participants in rugby or other contact sports with this or other appropriate herpes simplex vaccine.
authors.affiliation: Department of Infection, Medical School, University of Birmingham, U.K.
authors.forename: G R
authors.initials: GR
authors.lastname: Skinner
authors.forename: J
authors.initials: J
authors.lastname: Davies
authors.forename: A
authors.initials: A
authors.lastname: Ahmad
authors.forename: P
authors.initials: P
authors.lastname: McLeish
authors.forename: A
authors.initials: A
authors.lastname: Buchan
mesh_terms: D000293:Adolescent; D000328:Adult; D004196:Disease Outbreaks; D005260:Female; D005500:Follow-Up Studies; D005538:Football; D006561:Herpes Simplex / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission*; D006801:Humans; D008297:Male; D012747:Sexual Partners; D018139:Simplexvirus / Q000276:immunology*; D006113:United Kingdom / Q000453:epidemiology; D014611:Vaccination; D015164:Vaccines, Inactivated / Q000008:administration & dosage; D014765:Viral Vaccines / Q000008:administration & dosage*
chemical_list: D015164:Vaccines, Inactivated; D014765:Viral Vaccines