Induction of Th1 cytokine responses by mycobacterial antigens in leprosy.
Twelve mycobacterial antigens were compared for induction of gamma interferon (IFN-gamma) secretion by human blood mononuclear cells of patients with leprosy. Fractionated Mycobacterium leprae antigens containing cell wall proteins or cytosolic and membrane proteins induced good IFN-gamma responses in tuberculoid leprosy patients. Lipoarabinomannan from M. tuberculosis Erdman and M. leprae mycolylarabinogalactan peptidoglycan were the poorest IFN-gamma inducers.
Dockrell
H M
HM
Molecular Immunology Unit, Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, United Kingdom. h.dockrell@lshtm.ac.uk
Young
S K
SK
Britton
K
K
Brennan
P J
PJ
Rivoire
B
B
Waters
M F
MF
Lucas
S B
SB
Shahid
F
F
Dojki
M
M
Chiang
T J
TJ
Ehsan
Q
Q
McAdam
K P
KP
Hussain
R
R
D000942:Antigens, Bacterial / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D015847:Interleukin-4 / Q000096:biosynthesis; D015848:Interleukin-5 / Q000096:biosynthesis; D007918:Leprosy / Q000276:immunology*; D009166:Mycobacterium leprae / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*
D000942:Antigens, Bacterial; D015848:Interleukin-5; D015847:Interleukin-4; D007371:Interferon-gamma