[Morphometric study of the degree of aggregation of thyrocytes as a function of the form of thyroid gland disease].
It is determined morphometrically that histogram distribution of the parameters reflecting the degree of aggregation of follicular cells depends upon the nature of thyroid disease. In thyroid carcinoma, the distribution of values of such parameters as area, perimeter, minimal and maximal diameters, moment of inertia and number of cells in the aggregate has a dome-shaped shape, while for follicular adenoma as well as for nodular colloid and diffuse toxic goiter or for autoimmune thyroiditis exponential-like dependence was typical. For such parameters, as mean diameter, mean and mean maximal distance between the cells in the aggregate and coordinate deviation distribution had a dome-like shape with maximum in the 3rd range in malignant tumors and in the 2nd one for other diseases, the revealed phenomena can be used as an additional diagnostic criterion of malignant transformation of thyroid follicular cells.
Kirillov
V A
VA
Iushchenko
Iu P
IuP
Demidchik
E P
EP
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002449:Cell Aggregation; D002648:Child; D002675:Child, Preschool; D005260:Female; D006042:Goiter / Q000473:pathology; D006801:Humans; D008297:Male; D013959:Thyroid Diseases / Q000473:pathology*; D013961:Thyroid Gland / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000473:pathology; D013967:Thyroiditis, Autoimmune / Q000473:pathology