[Immune response of lymphocytes: new concepts].
The paper discusses a new conceptual model of an immune response, whose basis is formed by the data on the heterogeneity of antigen suspensions, which have been disregarded by the earlier theories. It also concerns with the fact that some cells can show different responses to various antigen dosages. That the cells responsive to an antigen increase in number is regarded not only a process of differentiation, accompanied by its proliferation, but a gradual detection of cells sensitized by different dosages that determine the rate of manifestations and intensity of a response. The paper provides evidence for the hypothesis of the nature of plasma cells, deals with the mechanisms of T- and B-lymphocytic relationships.
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D000818:Animals; D000917:Antibody Formation / Q000235:genetics; D000936:Antigen-Antibody Complex; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology; D002454:Cell Differentiation; D002455:Cell Division; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics / Q000276:immunology; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D009154:Mutation; D010641:Phenotype; D010950:Plasma Cells / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D000936:Antigen-Antibody Complex; D000949:Histocompatibility Antigens Class II; D007136:Immunoglobulins