title: [Current aspects of ACE inhibitor therapy from the cardiologic viewpoint].
abstract: From a cardiologist's view there are several established indications for the use of ACE-inhibitors like hypertension, heart failure and acute myocardial infarction. In other forms of coronary artery disease like stable and unstable angina and prevention of arteriosclerotic complications. ACE-inhibitors are under discussion. As antihypertensives ACE-inhibitors are about equally effective as calcium blockers, betablockers and diuretics without the negative effects on lipid metabolism and insulin sensitivity. Vascular and cardial remodelling are prevented with ACE-inhibitors at least to a certain degree. In heart failure ACE-inhibitors reduce morbidity and mortality, if left ventricular ejection fraction is reduced. In acute myocardial infarction ACE-inhibitors are indicated in overt heart failure, depressed left ventricular function and high-risk-patients. In silent ischaemia and secondary prevention ACE-inhibitors are under discussion.
authors.affiliation: Klinischen Abteilung für Kardiologie, Medizinischen Universitätsklinik Graz.
authors.forename: W
authors.initials: W
authors.lastname: Klein
authors.forename: B
authors.initials: B
authors.lastname: Eber
authors.forename: R
authors.initials: R
authors.lastname: Gasser
authors.forename: K
authors.initials: K
authors.lastname: Stoschitzky
authors.forename: M
authors.initials: M
authors.lastname: Schumacher
authors.forename: F M
authors.initials: FM
authors.lastname: Fruhwald
authors.forename: R
authors.initials: R
authors.lastname: Zweiker
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D015996:Survival Rate; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000187:drug effects / Q000502:physiology
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors