title: Targeting signal transduction in the discovery of antiproliferative drugs.
abstract: Derangements in the signal transduction pathways controlling cell growth can lead to cancer. Two areas of growth factor signaling offer novel opportunities for therapeutic intervention: protein-protein interactions and phosphorylation cascades.
authors.affiliation: Parke-Davis Pharmaceutical Research, Warner-Lambert Company, 2800 Plymouth Road, Ann Arbor, MI 48105, USA.
authors.forename: A R
authors.initials: AR
authors.lastname: Saltiel
authors.forename: T K
authors.initials: TK
authors.lastname: Sawyer
mesh_terms: D002455:Cell Division / Q000187:drug effects*; D006133:Growth Substances / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*; D018909:src Homology Domains
chemical_list: D006133:Growth Substances; D011494:Protein Kinases