title: Small intrapulmonary artery lung prototypes. Mathematical modeling of gas transfer.
abstract: Two diffusion models have been developed to analyze gas transfer data previously measured in an intravascular artificial lung consisting of a central gas supply catheter from which are tethered a large number of blind-ended microporous fibers of equal length. A convective-diffusion model (CD) describes the countercurrent transfer of a binary gas pair when gas is supplied at constant pressure conditions, and a well mixed (WM) cycled pressure model predicts transfer when the gas supply pressure is time cycled between compression and vacuum conditions. Regression of gas to gas and liquid to gas excretion data with the CD model resulted in estimates of the liquid phase mass transfer coefficient kAI. Because these values were intermediate between the kAI expected for flow parallel to a cylinder and for flow normal to a cylinder, gas transfer was influenced by both the tethered region of the fiber that was nearly perpendicular to the axis of the test section and the free end of the fiber that rested along the wall of the test section. With a time cycled gas supply pressure, the enhanced carbon dioxide and oxygen excretion predicted by the WM model was similar to the data, but a loss in transfer efficiency with fiber length was not accounted for by the theory.
authors.affiliation: Department of Chemical Engineering, Pennsylvania State University, University Park 16802, USA.
authors.forename: H
authors.initials: H
authors.lastname: Baskaran
authors.forename: V
authors.initials: V
authors.lastname: Nodelman
authors.forename: J S
authors.initials: JS
authors.lastname: Ultman
authors.forename: R B
authors.initials: RB
authors.lastname: Richard
authors.forename: G
authors.initials: G
authors.lastname: Panol
authors.forename: K M
authors.initials: KM
authors.lastname: High
authors.forename: M T
authors.initials: MT
authors.lastname: Snider
mesh_terms: D000465:Algorithms; D001187:Artificial Organs; D002245:Carbon Dioxide; D004867:Equipment Design; D006801:Humans; D066298:In Vitro Techniques; D008168:Lung; D008433:Mathematics; D008954:Models, Biological; D010100:Oxygen; D011651:Pulmonary Artery; D011659:Pulmonary Gas Exchange / Q000502:physiology
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen