Novel diterpenoid diacylglycerols from marine molluscs: potent morphogens and protein kinase C activators.
Five novel 1,2-sn-diacylglycerols with diterpenoid acyl moieties in the sn-1 position were isolated and characterized, together with the corresponding 1,3-sn-diacylglycerols, from three species of dorid nudibranchs molluscs. Their potent activity as morphogens in vivo in the Hydra tentacle regeneration assay and their parallel activity as activators of rat brain protein kinase C (PKC) in vitro are reported here. Our findings promote the use of these compounds as useful molecular probes for both in vivo and in vitro studies on the participation of PKC in cell development.
De Petrocellis
L
L
Istituo di Cibernetica, C.N.R., Viale Toiano 6, I-80072 Arco Felice, Naples, Italy.
Orlando
P
P
Gavagnin
M
M
Ventriglia
M
M
Cimino
G
G
Di Marzo
V
V
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D004075:Diglycerides / Q000494:pharmacology*; D004224:Diterpenes / Q000494:pharmacology*; D004789:Enzyme Activation; D008974:Mollusca / Q000737:chemistry*; D010718:Phosphatidylserines / Q000494:pharmacology; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats
D004075:Diglycerides; D004224:Diterpenes; D010718:Phosphatidylserines; D011493:Protein Kinase C; D002118:Calcium