Vitamin E concentration in breast adipose tissue of breast cancer patients (Kuopio, Finland).
Previous data on animals and humans suggest that vitamin E may be a protective factor against cancer. A low dietary vitamin E intake has been suggested to increase the risk of breast cancer. We examined the dietary intake and the concentration of vitamin E in breast adipose tissue of women in Kuopio, Finland, diagnosed between 1990 and 1992 with benign breast disease (n = 34) and with breast cancer (n = 32). In postmenopausal women, lower dietary intake (P = 0.006) and a smaller concentration of vitamin E in breast adipose tissue (P = 0.024) were observed in breast cancer patients than in subjects with benign breast disease. Partial correlation showed that the vitamin E concentration in the breast adipose tissue correlated positively with the dietary intake of vitamin E (r = 0.25, P = 0.023), indicating that the vitamin E concentration in breast adipose tissue reflects the dietary intake of vitamin E.
Zhu
Z
Z
Department of Clinical Nutrition, University of Kuopio, Finland.
Parviainen
M
M
Männistö
S
S
Pietinen
P
P
Eskelinen
M
M
Syrjänen
K
K
Uusitupa
M
M
D000273:Adipose Tissue / Q000737:chemistry*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D015992:Body Mass Index; D001940:Breast / Q000737:chemistry*; D001941:Breast Diseases / Q000378:metabolism; D001943:Breast Neoplasms / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004032:Diet; D005247:Feeding Behavior; D005260:Female; D005387:Finland; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause; D017697:Premenopause; D012044:Regression Analysis; D012307:Risk Factors; D014810:Vitamin E / Q000008:administration & dosage / Q000032:analysis*
D014810:Vitamin E