title: Tc-99m stannous colloid-labeled leukocyte scintigraphy in the evaluation of the painful arthroplasty.
abstract: The aim of this study was to evaluate the utility of scintigraphy using leukocytes labeled with Tc-99m stannous colloid in the assessment of painful arthroplasties. The results of three-phase bone scintigraphy and imaging with Tc-99m-labeled leukocytes in 40 patients with painful joint prostheses, requiring the exclusion of infection are reported. Results were compared with microbiologic culture and/or long-term clinical review. Bone scintigraphy had a sensitivity of 100%, a specificity of 64%, and a diagnostic accuracy of 73% in detecting prosthetic infection. Tc-99m-labeled leukocytes yielded a sensitivity of 70%, a specificity of 100%, and a diagnostic accuracy of 93%. Leukocyte scintigraphy improves the specificity of bone scintigraphy in the assessment of the painful prosthetic joint. A positive study is highly suggestive of infection and warrants appropriate treatment.
authors.affiliation: Department of Nuclear Medicine, Concord Hospital, Sydney, Australia.
authors.forename: K K
authors.initials: KK
authors.lastname: Chik
authors.forename: M A
authors.initials: MA
authors.lastname: Magee
authors.forename: W J
authors.initials: WJ
authors.lastname: Bruce
authors.forename: R J
authors.initials: RJ
authors.lastname: Higgs
authors.forename: M G
authors.initials: MG
authors.lastname: Thomas
authors.forename: K C
authors.initials: KC
authors.lastname: Allman
authors.forename: H
authors.initials: H
authors.lastname: Van der Wall
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001842:Bone and Bones / Q000000981:diagnostic imaging; D003102:Colloids; D005260:Female; D006621:Hip Joint / Q000000981:diagnostic imaging; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging; D007720:Knee Prosthesis / Q000009:adverse effects*; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D016459:Prosthesis-Related Infections / Q000000981:diagnostic imaging*; D012372:ROC Curve; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D017556:Technetium Compounds; D017971:Tin Compounds
chemical_list: D003102:Colloids; D017556:Technetium Compounds; D017971:Tin Compounds; C033493:technetium Tc 99m tin colloid