In vivo quantification of muscle damage in dogs after intramuscular administration of drugs.
Intramuscular injections of a vitamin B preparation, imidocarb, imidocarb+lidocaine, and a preparation of salts of fatty acids produced significant increases in plasma creatine kinase activity in groups of five to six dogs. Activities peaked between 3 and 8 h, and were as high as 23 times base values with the fatty acid salts preparation. Quantification of the equivalent muscle damage gave means of 0.04, 0.25, 0.23 and 0.30 g kg-1 body weight, respectively, for each of the above preparations.
Aktas
M
M
Département de Physiopathologie, URA-INRA Physiopathologie et Toxicologie Expérimentales, Toulouse, France.
Vinclair
P
P
Lefebvre
H P
HP
Toutain
P L
PL
Braun
J P
JP
D000779:Anesthetics, Local / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D003402:Creatine Kinase / Q000097:blood; D004285:Dogs; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007095:Imidocarb / Q000008:administration & dosage / Q000494:pharmacology*; D007273:Injections, Intramuscular; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects*; D013831:Thiamine / Q000008:administration & dosage / Q000494:pharmacology*
D000779:Anesthetics, Local; D000981:Antiprotozoal Agents; D005231:Fatty Acids, Unsaturated; D007095:Imidocarb; D008012:Lidocaine; D003402:Creatine Kinase; D013831:Thiamine