title: Nucleolar organizer regions in pituitary adenomas.
abstract: In this study, thirty-two non-functional and eighteen functional pituitary adenomas were analysed for the presence of argyrophilic nucleolar organizer regions (Ag-NORs) in paraffin sections, using an one-step silver-colloidal staining method. Differences in the mean Ag-NOR numbers of functional pituitary adenomas were statistically significant than those of non-functional pituitary adenomas. It is being emphasised that evaluation of Ag-NOR count is a more reliable index than the presence of mitotic figures in predicting the proliferative activity as well as possibility of recurrence in a patient with pituitary adenoma.
authors.affiliation: Department of Pathology, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Trivandrum, India.
authors.forename: V V
authors.initials: VV
authors.lastname: Radhakrishnan
authors.forename: N S
authors.initials: NS
authors.lastname: Radhakrishnan
authors.forename: B K
authors.initials: BK
authors.lastname: Misra
authors.forename: D
authors.initials: D
authors.lastname: Rout
mesh_terms: D000236:Adenoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009697:Nucleolus Organizer Region / Q000473:pathology*; D010911:Pituitary Neoplasms / Q000473:pathology*; D012834:Silver; D013194:Staining and Labeling
chemical_list: D012834:Silver