title: Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling.
abstract: Acylated homoserine lactones (AHLs) play a widespread role in intercellular communication among bacteria. The Australian macroalga Delisea pulchra produces secondary metabolites which have structural similarities to AHL molecules. We report here that these metabolites inhibited AHL-controlled processes in prokaryotes. Our results suggest that the interaction between higher organisms and their surface-associated bacteria may be mediated by interference with bacterial regulatory systems.
authors.affiliation: Department of Microbiology, The Technical University of Denmark, Lyngby.
authors.forename: M
authors.initials: M
authors.lastname: Givskov
authors.forename: R
authors.initials: R
authors.lastname: de Nys
authors.forename: M
authors.initials: M
authors.lastname: Manefield
authors.forename: L
authors.initials: L
authors.lastname: Gram
authors.forename: R
authors.initials: R
authors.lastname: Maximilien
authors.forename: L
authors.initials: L
authors.lastname: Eberl
authors.forename: S
authors.initials: S
authors.lastname: Molin
authors.forename: P D
authors.initials: PD
authors.lastname: Steinberg
authors.forename: S
authors.initials: S
authors.lastname: Kjelleberg
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000378:metabolism; D000215:Acylation; D002450:Cell Communication; D005057:Eukaryotic Cells / Q000382:microbiology / Q000502:physiology; D007783:Lactones / Q000378:metabolism*; D011387:Prokaryotic Cells / Q000502:physiology; D000461:Rhodophyta / Q000382:microbiology / Q000502:physiology*; D012705:Serratia / Q000737:chemistry / Q000502:physiology*
chemical_list: D007783:Lactones; C088386:homoserine lactone; D015107:4-Butyrolactone