New naphthyloxyalkyl beta-diketone and 3,5-dimethylisoxazole derivatives as potential antiviral agents.
Ten new compounds having 3-[(2-naphthyloxy)alkyl]-2,4-pentanedione and 4-[(2-naphthyloxy)alkyl]-3,5-dimethylisoxazole structures were synthesized and their cytotoxicities and antiviral activities investigated. 3-[6-(2-Naphthyloxy)hexyl]-2,4-pentandione possessing inhibitory activity on the replication of both adenovirus type 5 and poliovirus type 1 at 20 micrograms/ml was the most active compound in the series.
Balkan
A
A
Hacettepe University, Faculty of Pharmacy, Dept. of Pharmaceutical Chem., Ankara-Turkey.
Akgün
H
H
Parali
N
N
Ertan
M
M
Açikgöz
C
C
Ustaçelebi
S
S
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000998:Antiviral Agents; D007555:Isoxazoles