title: Effects of transdermal nicotine on lower esophageal sphincter and esophageal motility.
abstract: Cigarette smoking has been shown to decrease lower esophageal sphincter pressure (LESP) by 19-42%. This decrease in LESP may be due to nicotine in the cigarette smoke or substances other than nicotine. The aim of this study was to evaluate the effects of a nicotine patch on esophageal motility since nicotine patches are devoid of all toxins present in the cigarette smoke except the nicotine. Ten healthy nonsmoking volunteers underwent baseline esophageal manometry. Esophageal manometry was repeated after placing a nicotine transdermal patch (Nicotrol) designed to deliver 15 mg of nicotine per day. The parameters that were compared included LESP by rapid pull-through (LESP-RPT) and station pull-through (LESP-SPT), LES relaxation, and velocity, amplitude, and duration of esophageal contractions. Plasma nicotine and cotinine levels were measured prior to baseline manometry and after 12 hr of placing the nicotine patch, the LESP-RPT decreased by 31% from 17.4 +/- 6.1 to 12.1 +/- 3.3 (P = 0.013) and the LESP-SPT by 27% from 13.4 +/- 5.4 to 9.8 +/- 4.8 (P = 0.029) after the nicotine patch. LES relaxation was present in 100% before and after nicotine patch. There were no significant differences in velocity, duration, and amplitude of esophageal contractions after the nicotine patch. Plasma nicotine and cotinine was absent in all subjects at baseline but was significantly elevated after 12 hr of nicotine patch. Transdermal delivery of nicotine results in a significant reduction in LESP in healthy subjects without effecting LES relaxation or esophageal body motility.
authors.affiliation: Gastroenterology Service, Brooke Army Medical Center, San Antonio, Texas 78234-6200, USA.
authors.forename: S C
authors.initials: SC
authors.lastname: Kadakia
authors.forename: H R
authors.initials: HR
authors.lastname: De La Baume
authors.forename: R T
authors.initials: RT
authors.lastname: Shaffer
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D003367:Cotinine / Q000097:blood; D004943:Esophagogastric Junction / Q000187:drug effects*; D004947:Esophagus / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006261:Headache / Q000139:chemically induced; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D009538:Nicotine / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood; D010528:Peristalsis / Q000187:drug effects; D012016:Reference Values; D007319:Sleep Initiation and Maintenance Disorders / Q000139:chemically induced
chemical_list: D009538:Nicotine; D003367:Cotinine