Synthesis and inhibitory effects of 2-pyridyl-2-thiobenzoxazole and 2-pyridyl-2-thiobenzimidazole derivatives on arachidonic acid metabolism.
A series of new 2-pyridyl-2-thiobenzoxazole and 2-pyridyl-2-thiobenzimidazole compounds was prepared and investigated by a number of in vitro methods in order to determine their prostaglandin synthesis inhibitory activity. The most active compound decreases prostaglandin production and carrageenin edema, but has a less platelet antiaggregatory activity.
Lagorce
J F
JF
Department of Organic and Therapeutic Chemistry, Faculty of Pharmacy, University of Limoges, France.
Fatimi
J
J
Lakhdar
M
M
Chabernaud
M L
ML
Buxeraud
J
J
Raby
C
C
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D016718:Arachidonic Acid / Q000378:metabolism*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D015232:Dinoprostone / Q000378:metabolism; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D011448:Prostaglandin Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013582:Synovial Fluid / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001562:Benzimidazoles; D001583:Benzoxazoles; D010975:Platelet Aggregation Inhibitors; D011448:Prostaglandin Antagonists; D016718:Arachidonic Acid; D015232:Dinoprostone