Clinical significance of Ki-67 staining index in acoustic neurinoma.
The correlation between various clinical parameters and MIB-1 (Ki-67) staining indices was evaluated in 58 acoustic neurinomas. The index ranged from 0.37% to 6.61% (mean 1.70%), and did not correlate with age, sex, or initial tumor volume. Sixteen of the 18 tumors removed subtotally or partially showed regrowth, and two showed a volume reduction. The 16 patients with regrowth were divided into two groups according to Ki-67 staining index, < 2.00% and > or = 2.00%. These groups had a significant difference in tumor doubling time (TDT). In addition, there was a significant logarithmic correlation between Ki-67 staining index and TDT. Ki-67 staining index can be used as an index of regrowth rate in partially or subtotally removed acoustic neurinomas. Intraoperative assessment of Ki-67 staining index may be useful for better management planning as well as the estimation of prognosis.
Yokoyama
M
M
Department of Neurosurgery, Shiga University of Medical Science, Ohtsu.
Matsuda
M
M
Nakasu
S
S
Nakajima
M
M
Handa
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis*; D002455:Cell Division / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009464:Neuroma, Acoustic / Q000453:epidemiology / Q000473:pathology*
D000951:Antigens, Neoplasm; D019394:Ki-67 Antigen