Childhood acute lymphoblastic leukaemia presenting as jaundice.
An unusual presentation of acute lymphoblastic leukaemia (ALL) in a 6-year-old girl is reported. She presented with unilateral cervical lymphadenopathy, a mixed obstructive/cholestatic jaundice and a progressive pancytopenia. Ultrasound examination revealed an obstructed common bile duct with gross thickening of the wall of the duct and intrahepatic bile duct dilatation. The jaundice resolved with high dose intravenous (i.v.) methylprednisolone. It is postulated that this was due to infiltration of the common bile duct, given the failure to demonstrate any other cause for the bile duct pathology.
Alvaro
F
F
Dept. of Oncology, Women's and Children's Hospital, North Adelaide, Australia.
Jain
M
M
Morris
L L
LL
Rice
M S
MS
D002648:Child; D002779:Cholestasis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D003135:Common Bile Duct / Q000473:pathology*; D005260:Female; D006801:Humans; D017254:Leukemic Infiltration / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D014463:Ultrasonography