title: CUG codons in Candida spp..
abstract: Codon CUG is used for serine instead of for leucine, its usual assignment, in several yeasts of the genus Candida. We propose a series of steps for the reassignment, including disappearance of leucine CUG and its anticodon CAG, formation of a new serine tRNA, with anticodon CAG, from a duplication of the gene for serine tRNA (IGA), and then production of CUG codons by mutation at sites that are mostly "nonessential."
authors.affiliation: Space Sciences Laboratory, University of California, Berkeley 94608, USA.
authors.forename: T H
authors.initials: TH
authors.lastname: Jukes
authors.forename: S
authors.initials: S
authors.lastname: Osawa
mesh_terms: D000926:Anticodon / Q000235:genetics; D001483:Base Sequence; D002175:Candida / Q000145:classification / Q000235:genetics*; D003062:Codon / Q000235:genetics*; D004271:DNA, Fungal / Q000235:genetics; D019143:Evolution, Molecular; D007930:Leucine / Q000235:genetics; D008957:Models, Genetic; D012331:RNA, Fungal / Q000235:genetics; D012694:Serine / Q000235:genetics
chemical_list: D000926:Anticodon; D003062:Codon; D004271:DNA, Fungal; D012331:RNA, Fungal; D012694:Serine; D007930:Leucine