The different effect of salbutamol and aminophylline on platelet activating factor-induced plasma exudation into guinea pig tracheal wall and lumen.
We examined the effects of salbutamol, aminophylline and verapamil on plasma exudation into airway wall and lumen in guinea pig trachea isolated in situ. Platelet-activating factor (PAF) (50 ng/kg) induced plasma exudation into both the tissue and lumen. Aminophylline (25 mg/kg) eliminated PAF-induced plasma leakage in the tissue and lumen. Verapamil (500 micrograms/kg) had neither effect. Salbutamol (160 micrograms/kg) significantly reduced PAF-induced plasma exudation in the tissue and enhanced plasma recovery in the airway lumen. We conclude that aminophylline inhibited microvascular leakage whereas salbutamol facilitates exudated plasma across epithelium and reduced its accumulation in the tissue.
Liu
C Y
CY
Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan, R.O.C.
Kuo
H P
HP
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000420:Albuterol / Q000494:pharmacology*; D000628:Aminophylline / Q000494:pharmacology*; D000818:Animals; D001993:Bronchodilator Agents / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects*; D006168:Guinea Pigs; D008297:Male; D010972:Platelet Activating Factor / Q000494:pharmacology*; D014132:Trachea / Q000378:metabolism*; D014700:Verapamil / Q000494:pharmacology
D000318:Adrenergic beta-Agonists; D001993:Bronchodilator Agents; D010972:Platelet Activating Factor; D000628:Aminophylline; D014700:Verapamil; D000420:Albuterol