Endothelin plasma levels in primary amenorrheic adolescents before and after estrogen treatment.
OBJECTIVE
We evaluated the effect of estrogen administration on endothelin (ET) secretion in primary amenorrheic (PA) adolescent girls.


METHODS
Fifteen PA adolescents (ten hypergonadotropic, group A; five hypogonadotropic, group B) were treated with estrogen and progestogen tablets. A control group of ten healthy adolescents (group C) was included in the study. The ET 1-21, FSH, and LH plasma levels were tested before treatment (PrT) and immediately after the last estrogen tablet but before the progestogen administration (PoT).


RESULTS
A statistically significant difference (P < .01) in ET 1-21 plasma values was found between PrT (9.66 +/- 0.80 pmol/L) and PoT (7.56 +/- 0.89 pmol/L) levels in group A cases. A similar reduction (P < .05) was recorded between PrT (8.06 +/- 0.46 pmol/L) and PoT (5.59 +/- 0.53 pmol/L) ET 1-21 plasma levels in group B cases. Endothelin 1-21 plasma PrT values were higher in both group A and B cases in comparison with controls (6.66 +/- 0.44 pmol/L; P < .01, P < .1, respectively).


CONCLUSIONS
Estrogens administered to PA adolescents reduce ET 1-21 plasma levels in both hyper-and hypogonadotropism.
Creatsas
G C
GC
First Department of Obstetrics and Gynecology, Alexandra Hospital, University of Athens, Greece.
Malamitsi-Puchner
A B
AB
Hassan
E A
EA
Economou
E B
EB
Aravantinos
D I
DI
D000293:Adolescent; D000568:Amenorrhea / Q000097:blood* / Q000188:drug therapy; D015331:Cohort Studies; D019332:Endothelin-1 / Q000097:blood* / Q000187:drug effects / Q000378:metabolism; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000378:metabolism; D006065:Gonadotropins, Pituitary / Q000097:blood* / Q000378:metabolism; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood / Q000187:drug effects / Q000378:metabolism; D016896:Treatment Outcome
D019332:Endothelin-1; D004966:Estrogens, Conjugated (USP); D006065:Gonadotropins, Pituitary; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone