title: Measurement of cerebral blood volume with subtraction three-dimensional functional CT.
abstract: OBJECTIVE
  To implement a three-dimensional subtraction functional CT technique to permit rapid quantitative mapping of regional cerebral blood volume (CBV).
  
  
  METHODS
  The 3-D functional CT technique was implemented in a rabbit model using normal and ischemic animals. Two spiral data acquisitions were performed, one before and one during biphasic administration of contrast material. CBV maps were then produced on a voxel-by-voxel basis through the whole brain.
  
  
  RESULTS
  The average normal CBV was 3.3 +/- 0.4 mL/100 g (n = 7), and the regional values were 4.5 +/- 0.6 mL/100 g for cortical gray matter, 2.5 +/- 0.6 mL/100 g for white matter, and 3.7 +/- 0.4 mL/100 g for the basal ganglia. The CBVs in ischemic regions were 1.5 +/- 0.4 mL/100 g, 0.7 +/- 0.7 mL/100 g, and 1.8 +/- 0.9 mL/100 g, respectively.
  
  
  CONCLUSIONS
  Subtraction 3-D functional CT is a fast, potentially cost-effective method with which to assess whole-brain CBV. Because the data collected in 3-D functional CT imaging also can be used to produce large-vessel angiograms, its use in a clinical setting can provide a multiparametric study of cerebrovascular abnormalities that encompasses both large and small vessel circulations for patients being examined for stroke.
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Boston, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Hamberg
authors.forename: G J
authors.initials: GJ
authors.lastname: Hunter
authors.forename: D
authors.initials: D
authors.lastname: Kierstead
authors.forename: E H
authors.initials: EH
authors.lastname: Lo
authors.forename: R
authors.initials: R
authors.lastname: Gilberto González
authors.forename: G L
authors.initials: GL
authors.lastname: Wolf
mesh_terms: D000818:Animals; D001810:Blood Volume; D002560:Cerebrovascular Circulation; D007091:Image Processing, Computer-Assisted; D011817:Rabbits; D013382:Subtraction Technique; D014057:Tomography, X-Ray Computed / Q000379:methods*