title: Pyrrolosporin A, a new antitumor antibiotic from Micromonospora sp. C39217-R109-7. II. Isolation, physico-chemical properties, spectroscopic study and X-ray analysis.
abstract: Pyrrolosporin A (1) is a new macrolide antitumor antibiotic possessing an unusual spiro-alpha-acyltetronic acid moiety. The antibiotic was isolated from the fermentation broth of Micromonospora sp. by vacuum liquid chromatography, crystallization and reversed phase HPLC (C18). The structure was determined by a combination of NMR, MS, IR, UV, X-ray analysis and degradation studies.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Schroeder
authors.forename: K L
authors.initials: KL
authors.lastname: Colson
authors.forename: S E
authors.initials: SE
authors.lastname: Klohr
authors.forename: M S
authors.initials: MS
authors.lastname: Lee
authors.forename: J A
authors.initials: JA
authors.lastname: Matson
authors.forename: L S
authors.initials: LS
authors.lastname: Brinen
authors.forename: J
authors.initials: J
authors.lastname: Clardy
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D018360:Crystallography, X-Ray; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D008847:Micromonospora / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D018942:Macrolides; C102425:pyrrolosporin A