Muscarinic receptors and insulin concentration in the rat pancreas after chronic alcohol intake and cholinergic stimulation.
The effects of chronic alcohol intake and carbachol stimulation on pancreatic muscarinic receptor binding and insulin concentrations were studied in the rat pancreas. There was a strong correlation between the number of muscarinic receptors and the concentration of insulin in the pancreas. The concentration of insulin decreased in the pancreas after long-term ethanol exposure and increased after carbachol stimulation. These results indicate that the secretion of insulin is mediated via the muscarinic receptor pathway, and that the changes in the number of muscarinic receptors may have a role in insulin deficiency after long-term alcohol consumption.
Laine
V J
VJ
Department of Pathology, University of Turku, Finland.
Huupponen
R
R
Kaila
T
T
Gronroos
J
J
Nevalainen
T J
TJ
D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000378:metabolism* / Q000633:toxicity*; D007328:Insulin / Q000378:metabolism*; D008297:Male; D019832:N-Methylscopolamine; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism*; D011869:Radioligand Assay; D051381:Rats; D017207:Rats, Sprague-Dawley; D011976:Receptors, Muscarinic / Q000737:chemistry / Q000187:drug effects*; D012602:Scopolamine Derivatives / Q000032:analysis
D007328:Insulin; D011976:Receptors, Muscarinic; D012602:Scopolamine Derivatives; D000431:Ethanol; D002217:Carbachol; D019832:N-Methylscopolamine