title: Kinetics of circulating adhesion molecules and chemokines after mechanical trauma and burns.
abstract: OBJECTIVE
  To assess the role of circulating adhesion molecules and chemotactic cytokines within different settings of major trauma.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Teaching hospitals, USA and Germany.
  
  
  METHODS
  Two groups of patients with multiple injuries (group I n = 155 and group II n = 12) with mean (SEM) injury severity scores (ISS) of 35 (4) and 32 (4) points, respectively, and 18 burned patients with a mean of ISS 38 (9) points.
  
  
  METHODS
  Serum samples were collected at the site of the accident and on admission to the (Group I) as well as during the post-trauma course in the hospital (Group II: days 1, 3, 5, 7, 10; Group III; weekly, up to week 10).
  
  
  METHODS
  Measurement of concentrations of soluble (s) adhesion molecules (sE-selectin, sP-selectin), and chemotactic cytokines (interleukin-8 [IL-8], epithelial cell derived neutrophil activating peptide 78 [ENA-78]) in serum after major mechanical trauma and burns.
  
  
  RESULTS
  High concentrations of ENA-78 and sP-selectin were already present at the site of accident as well as one hour after injury. During recovery from the injuries, persistently high concentrations of IL-8, ENA-78, and sP-selectin were found, but sE-selectin was increased only during the first week after major trauma.
  
  
  CONCLUSIONS
  Massive tissue trauma causes immediate activation of selected chemokines and adhesion molecules within minutes of the injury which will then persist depending on the type and severity of the injury for a substantial length of time. There was, however, no correlation between serum concentrations of the mediators investigated and susceptibility to complications or outcome.
authors.affiliation: Department of Surgery, Ludwig-Maximilians-University, Klinikum Grosshadern, Munich, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Schinkel
authors.forename: E
authors.initials: E
authors.lastname: Faist
authors.forename: S
authors.initials: S
authors.lastname: Zimmer
authors.forename: S
authors.initials: S
authors.lastname: Piltz
authors.forename: A
authors.initials: A
authors.lastname: Walz
authors.forename: R
authors.initials: R
authors.lastname: Rose
authors.forename: E
authors.initials: E
authors.lastname: Höcherl
authors.forename: D
authors.initials: D
authors.lastname: Herndon
authors.forename: F W
authors.initials: FW
authors.lastname: Schildberg
mesh_terms: D000293:Adolescent; D000328:Adult; D001053:Apolipoproteins / Q000032:analysis; D002056:Burns / Q000097:blood*; D054365:Chemokine CXCL5; D018925:Chemokines / Q000097:blood*; D019743:Chemokines, CXC; D019040:E-Selectin / Q000097:blood; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000031:analogs & derivatives / Q000097:blood; D007700:Kinetics; D008297:Male; D009104:Multiple Trauma / Q000097:blood*; D019007:P-Selectin / Q000097:blood; D012189:Retrospective Studies; D019087:Selectins / Q000097:blood*; D000685:Serum Amyloid A Protein / Q000032:analysis
chemical_list: D001053:Apolipoproteins; C486263:CXCL5 protein, human; D054365:Chemokine CXCL5; D018925:Chemokines; D019743:Chemokines, CXC; D019040:E-Selectin; D016209:Interleukin-8; D019007:P-Selectin; D019087:Selectins; D000685:Serum Amyloid A Protein