title: Synthesis and antibacterial activity of 1-beta-methylcarbapenem having a 1,3-diazabicyclo[3.3.0]octan-4-one moiety.
abstract: The synthesis of new series of 1-beta-methylcarbapenems having a 1,3-diazabicyclo[3,3,0]octan-4-one moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram negative bacteria are reported and the effect of the substituent on the bicyclic ring was investigated and was in agreement with findings from our previous studies.
authors.affiliation: Division of Applied Science, Korea Institute of Science and Technology, Seoul, Korea.
authors.forename: K H
authors.initials: KH
authors.lastname: Nam
authors.forename: C H
authors.initials: CH
authors.lastname: Oh
authors.forename: J K
authors.initials: JK
authors.lastname: Cho
authors.forename: H J
authors.initials: HJ
authors.lastname: Kim
authors.forename: K S
authors.initials: KS
authors.lastname: Lee
authors.forename: J H
authors.initials: JH
authors.lastname: Cho
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D015780:Carbapenems / Q000138:chemical synthesis* / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems