An overdose fatality in a child involving disopyramide and sulindac.
The results of an accidental overdose fatality in a child involving disopyramide and sulindac are reported in this paper. Quantitation of disopyramide was performed by gas chromatography using codeine as the internal standard. Sulindac was assayed by high- performance liquid chromatography using ketoprofen as the internal standard. The postmortem blood concentrations of disopyramide and sulindac were 41.3 and 12.2 mg/L, respectively. The concentrations of disopyramide and sulindac were also quantitated in the liver, in bile, and in urine.
Singer
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P
Medical Examiner's Office, Edmonton, AB, Canada.
Mozayani
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A
D000889:Anti-Arrhythmia Agents / Q000378:metabolism / Q000506:poisoning*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism / Q000506:poisoning*; D001646:Bile / Q000187:drug effects / Q000378:metabolism; D002138:Calibration; D002675:Child, Preschool; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D004206:Disopyramide / Q000378:metabolism / Q000506:poisoning*; D062787:Drug Overdose / Q000401:mortality*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D013467:Sulindac / Q000378:metabolism / Q000506:poisoning*; D014018:Tissue Distribution
D000889:Anti-Arrhythmia Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013467:Sulindac; D004206:Disopyramide