Chemotherapy-associated oral mucosal lesions in patients with leukaemia or lymphoma.
In order to determine the incidence rate of oral lesions associated with chemotherapy, as well as well as its association with clinical and laboratory parameters and potential risk factors, 50 in-patients with non-Hodgkin's lymphoma or leukaemia under chemotherapy were followed from January 1993 to May 1994. Basal and weekly oral examinations were performed. Clinical and laboratory data were registered. Wilcoxon's rank sum test, chi square test, univariate and multivariate logistic regression analyses were used, 36 individuals with leukaemia and 14 with non-Hodgkin's lymphoma were followed for 158 weeks; mean age was 33 years (range 15-85). Oral lesion incidence rate was 45/100 patients-week. Exfoliative cheilitis and infections (herpes and candidosis) were the most common oral complications, followed by haemorrhagic lesions and mucositis. Haemorrhagic lesions correlated with thrombocytopenia (RR = 30.5). Etoposide administration (RR = 8.6), alkylating agents (RR = 15.6), a prior course of chemotherapy (RR = 23.2) and neutropenia (RR = 4.16) were predictors of mucositis. Oral lesions were a common complication in this study, and a possible association of mucositis with several factors is suggested.
Ramírez-Amador
V
V
Department of Health Care, Universidad Autonoma Metropolitana-Xochimilco, Mexico City, Mexico.
Esquivel-Pedraza
L
L
Mohar
A
A
Reynoso-Gómez
E
E
Volkow-Fernández
P
P
Guarner
J
J
Sánchez-Mejorada
G
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002613:Cheilitis / Q000139:chemically induced; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000139:chemically induced*; D009061:Mouth Mucosa / Q000187:drug effects; D009894:Opportunistic Infections / Q000139:chemically induced; D006472:Oral Hemorrhage / Q000139:chemically induced; D011446:Prospective Studies; D012307:Risk Factors; D013280:Stomatitis / Q000139:chemically induced
D000970:Antineoplastic Agents