Effect of KW-4679, an orally active anti-allergic drug, on antigen-induced airway hyperresponsiveness in actively sensitized guinea pigs.
We investigated the effect of KW-4679 ((Z)-11-[(3-dimethylamino)propylidene]-6,11-dihydrodibenz[b, e]oxepin-2- acetic acid monohydrochloride), an orally active anti-allergic drug, on antigen-induced airway hyperresponsiveness using two different indicators, pulmonary resistance (RL) and dynamic lung compliance (Cdyn), in actively sensitized guinea pigs. Oral administration of KW-4679 (0.1 and 1 mg/kg) 1 hr before aerosolized antigen exposure significantly inhibited the development of airway hyperresponsiveness to inhaled acetylcholine in RL and Cdyn in a dose-dependent manner. Terfenadine (10 mg/kg) also inhibited the development of airway hyperresponsiveness. These results indicate that KW-4679 could be useful in the treatment of bronchial asthma.
Kawasaki
H
H
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.
Manabe
H
H
Ohmori
K
K
D000109:Acetylcholine / Q000008:administration & dosage; D000403:Airway Resistance; D000818:Animals; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D016535:Bronchial Hyperreactivity / Q000209:etiology / Q000517:prevention & control*; D003990:Dibenzoxepins / Q000627:therapeutic use*; D006168:Guinea Pigs; D008170:Lung Compliance; D008297:Male; D000069605:Olopatadine Hydrochloride
D018926:Anti-Allergic Agents; D003990:Dibenzoxepins; D000069605:Olopatadine Hydrochloride; D000109:Acetylcholine