title: Diagnosis of malignant change in Paget's disease by Tl-201.
abstract: Scintigraphy using Tc-99m MDP and Tl-201 was performed in a patient with polyostotic Paget's disease and sarcomatous degeneration in the right iliac bone. Tc-99m MDP imaging showed abnormal uptake in both types of lesions. Tl-201 imaging showed increased uptake in the sarcomatous lesion and absent uptake in pagetic lesions. This result supports the idea that Tl-201 scintigraphy may have a potential role to play in the differentiation of Paget's disease from malignancy. To the authors' knowledge, Tl-201 has never been reported for the detection of sarcomatous change of pagetic bone.
authors.affiliation: Department of Nuclear Medicine, Portuguese Institute of Oncology, Lisbon, Portugal.
authors.forename: P
authors.initials: P
authors.lastname: Colarinha
authors.forename: A T
authors.initials: AT
authors.lastname: Fonseca
authors.forename: L
authors.initials: L
authors.lastname: Salgado
authors.forename: M R
authors.initials: MR
authors.lastname: Vieira
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging*; D001842:Bone and Bones / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007085:Ilium / Q000000981:diagnostic imaging*; D008875:Middle Aged; D010001:Osteitis Deformans / Q000000981:diagnostic imaging*; D012516:Osteosarcoma / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D013669:Technetium Tc 99m Medronate; D013794:Thallium Radioisotopes
chemical_list: D013794:Thallium Radioisotopes; D013669:Technetium Tc 99m Medronate