title: The emerging role of MIF in septic shock and infection.
abstract: The protein mediator described originally as macrophage migration inhibitory factor (MIF) has been "re-discovered" recently to be both a novel pituitary hormone and a pro-inflammatory, macrophage-derived cytokine. Emerging studies indicate that MIF plays a pivotal role not only in endotoxic shock but also in the host response to a variety of acute and chronic infections.
authors.affiliation: Picower Institute for Medical Research, Manhassett, New York 11030, USA.
authors.forename: J
authors.initials: J
authors.lastname: Bernhagen
authors.forename: T
authors.initials: T
authors.lastname: Calandra
authors.forename: R
authors.initials: R
authors.lastname: Bucala
mesh_terms: D000818:Animals; D006801:Humans; D007239:Infections / Q000503:physiopathology*; D008263:Macrophage Migration-Inhibitory Factors / Q000502:physiology*; D012772:Shock, Septic / Q000503:physiopathology*
chemical_list: D008263:Macrophage Migration-Inhibitory Factors