title: Anosmia following head trauma: preliminary study of steroid treatment.
abstract: Twenty patients with post-traumatic anosmia were subjected to olfactory function testing, including olfactory acuity tests using a T & T olfactometer and an intravenous olfaction test. T & T tests revealed complete loss in 14 patients. In the intravenous olfaction test, 14 patients showed no response and 5 patients showed abnormal responses. The severity of olfactory dysfunction showed no correlation with background factors such as the site of head trauma, the presence of the fracture of skull, the presence of unconsciousness, or the presence of head operation. As a preliminary study, seventeen patients were administered a corticosteroid, a topical nasal drop of 0.1% betamethasone for 12 patients and an oral administration of prednisolone for 5 patients. Four patients showed slight recovery of olfactory function following a corticosteroid therapy. Effects of corticosteroids on olfaction might be explained by regeneration of olfactory receptor cell axons and reestablishment of contact with cells in the olfactory bulb.
authors.affiliation: Department of Otolaryngology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ikeda
authors.forename: T
authors.initials: T
authors.lastname: Sakurada
authors.forename: T
authors.initials: T
authors.lastname: Takasaka
authors.forename: T
authors.initials: T
authors.lastname: Okitsu
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002648:Child; D006259:Craniocerebral Trauma / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D000857:Olfaction Disorders / Q000188:drug therapy* / Q000209:etiology*; D011239:Prednisolone / Q000627:therapeutic use; D011379:Prognosis; D012903:Smell / Q000502:physiology
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D011239:Prednisolone