Effects of different amounts of LH on superovulation induction with long-acting GnRH in an IVF program.
OBJECTIVE
To evaluate whether different doses of exogenous LH affect IVF outcome.


METHODS
Retrospective analysis of two consecutive trials.


METHODS
Infertility Unit of 1st Department of Obstetrics and Gynecology, University of Milan, Italy.


METHODS
Two groups of 40 eumennorrheic patients matched for age and indications for in vitro fertilization.


METHODS
After suppression with a GnRH analogue, both groups received equal amounts of FSH in the first five days of stimulation; after this, the proportions of LH administered were doubled in one group because a different preparation was in use.


METHODS
The following observations were compared: number of scans (days to hCG), number of oocytes retrieved, fertilization rate, quality and number of embryos transferred, pregnancy and abortion rate.


RESULTS
Doubling the amount of LH administered does not affect any outcome measure except the number of days of stimulation needed prior to hCG administration.


CONCLUSIONS
No significant difference was seen in terms of number of oocytes, embryo number and quality, pregnancy and abortion rate. The only difference was the length of the stimulation phase.
Ragni
G
G
First Department of Obstetrics and Gynecology University of Milan, Italy.
De Laurentis
L
L
Perotti
L
L
Serra
A D
AD
Vegetti
W
W
Crosignani
P G
PG
D000028:Abortion, Induced; D000328:Adult; D015331:Cohort Studies; D004624:Embryo Transfer / Q000145:classification / Q000706:statistics & numerical data; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage / Q000494:pharmacology; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D007986:Luteinizing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D009865:Oocytes / Q000145:classification / Q000187:drug effects / Q000502:physiology; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012189:Retrospective Studies; D013480:Superovulation / Q000187:drug effects*
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone