Tubuloreticular structures induced by rotavirus infection in HT-29 cells.
An electron microscopic study addressed morphological changes induced by rotavirus in the enterocyte-like cell line HT-29. Tubuloreticular structures were found in the latest stages of viral infection when cells, undergoing a cytopathic effect, detached from the substrate. Tubuloreticular structures were localized, together with viral particles, within highly dilated perinuclear cisternae. The results suggest that tubuloreticular structures evolve during interaction of rotavirus with the rough endoplasmic reticulum membranes.
Tinari
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Department of Ultrastructure, Istituto Superiore di Sanitá, Rome, Italy.
Ammendolia
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MG
Superti
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F
Donelli
G
G
D000230:Adenocarcinoma / Q000821:virology; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure*; D009395:Nephritis, Interstitial / Q000821:virology*; D012400:Rotavirus Infections / Q000473:pathology*; D014407:Tumor Cells, Cultured