Effect of zinc deficiency on chromosomal abnormalities in mice.
In the present study we investigated the effect of zinc-deficiency on chromosomal abnormalities and mitotic index, and the interaction of zinc-deficiency and methotrexate. Therefore, two zinc-deficient and two zinc-adequate diet received mouse groups were constituted. Methotrexate was injected to one of zinc-deficient and one of zinc-adequate diet groups. There were no structural and numerical abnormalities in all groups. However, mitotic index was significantly lower than other groups in zinc-deficient and methotrexate administered mice.
Ozkul
Y
Y
Department of Medical Biology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Dursun
N
N
Erenmemişoğlu
A
A
Süer
C
C
Saatçi
C
C
D000818:Animals; D001835:Body Weight; D001853:Bone Marrow / Q000473:pathology; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D004032:Diet; D004171:Diploidy; D005247:Feeding Behavior; D005260:Female; D008297:Male; D008727:Methotrexate / Q000494:pharmacology; D051379:Mice; D008940:Mitotic Index / Q000187:drug effects; D015032:Zinc / Q000008:administration & dosage / Q000172:deficiency* / Q000494:pharmacology
D015032:Zinc; D008727:Methotrexate