Warfarin--topical salicylate interactions: case reports.
This paper deals with two patients on warfarin in whom the use of topical methylsalicylate preparations led to clinically significant bleeding problems. The first patient required fresh frozen plasma to tide over the crisis while the second patient recovered spontaneously on stopping the warfarin temporarily. The possible mechanisms by which salicylates potentiate the anticoagulant effect of warfarin are briefly outlined.
Ramanathan
M
M
Department of Medicine, Taiping Hospital, Perak.
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D000925:Anticoagulants / Q000009:adverse effects*; D004347:Drug Interactions; D005260:Female; D005881:Gingiva / Q000098:blood supply; D006406:Hematoma / Q000139:chemically induced; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D012459:Salicylates / Q000009:adverse effects*; D013256:Steroids; D014859:Warfarin / Q000009:adverse effects*
D000893:Anti-Inflammatory Agents; D000925:Anticoagulants; D012459:Salicylates; D013256:Steroids; D014859:Warfarin