title: [Dependence of clinical course and outcome of chronic duodenitis on some features of its pathogenesis].
abstract: The effects of acid, infectious (Helicobacter pylori) and neuroendocrine factors on the course and outcome of chronic duodenitis were studied in 57 patients aged 15-35 years. Within 5-year follow-up ulcer emerged in 26% of duodenitis patients. Ulceration occurred as a result of high acid production in the basal and stimulated phases, contamination of pyloric-antral mucosa with Helicobacter pylori, unbalance of serum hormones T4, TTH, FSH, ACTH. In risk of ulcerogenesis there were psychological shifts with appearance of pathological reaction to the disease. Consideration of pathogenetic specificity of different duodenitis forms and basing on objective and subjective criteria allow identification of ulcer risk group and early start of optimal therapy.
authors.forename: R S
authors.initials: RS
authors.lastname: Bogachev
mesh_terms: D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D002908:Chronic Disease; D004381:Duodenal Ulcer / Q000209:etiology; D004382:Duodenitis / Q000097:blood / Q000209:etiology*; D005640:Follicle Stimulating Hormone / Q000097:blood; D005500:Follow-Up Studies; D005744:Gastric Acid / Q000378:metabolism; D005755:Gastrins / Q000097:blood; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D012307:Risk Factors; D013270:Stomach / Q000503:physiopathology; D013963:Thyroid Hormones / Q000097:blood; D013997:Time Factors
chemical_list: D005755:Gastrins; D013963:Thyroid Hormones; D000324:Adrenocorticotropic Hormone; D005640:Follicle Stimulating Hormone