title: Hemofiltration in a cardiac intensive care unit: time for a rational approach.
abstract: The typical annual expenditure for patients requiring continuous hemofiltration (CHF) is high. To audit the benefit of this expensive treatment, the outcome of 48 consecutive patients (34 men, 14 women; mean age, 65 years) requiring hemofiltration for acute renal failure was analyzed during a period of 24 months. The operations performed were 26 CABG, 8 AVR, 3 AVR/MVR, 2 post infarction VSD repairs, and 1 thoracoabdominal aneurysmectomy. Indications for hemofiltration were oliguria and fluid overload in 69%, uremia in 56%, acidosis in 33%, and hyperkemia in 13%. Twenty five patients (52%) died while in the hospital, and 10 more died within 9 months of discharge. Of the remaining 13 survivors, 6 (46%) were classified as III or IV according to the New York Heart Association classification system. The mean ITU and hospital stay per patient requiring CHF was 15.3 days and 25.4 days, respectively. There were no statistically significant differences between patients who did and did not survive in the hospital in age, pre-operative renal function, ejection fraction, duration of cardiopulmonary bypass, or urine output before CHF. However, there were no survivors when the cardiac index was less than 1.7 L/m2 and adrenalin requirement was more than 30 micrograms/min before CHF (seven patients). These results suggest that the short- and long-term outcome in patients requiring CHF after cardiac surgery is poor. Considering the large demand on resources, the use of CHF should be rationalized, particularly in patients with persistent low cardiac output.
authors.affiliation: Department of Cardiothoracic Surgery, Walsgrave Hospital, Coventry, United Kingdom.
authors.forename: G M
authors.initials: GM
authors.lastname: Tsang
authors.forename: I
authors.initials: I
authors.lastname: Khan
authors.forename: M
authors.initials: M
authors.lastname: Dar
authors.forename: D
authors.initials: D
authors.lastname: Clayton
authors.forename: D
authors.initials: D
authors.lastname: Waller
authors.forename: R L
authors.initials: RL
authors.lastname: Patel
mesh_terms: D058186:Acute Kidney Injury / Q000191:economics / Q000401:mortality / Q000628:therapy*; D000368:Aged; D002302:Cardiac Output; D006348:Cardiac Surgical Procedures / Q000009:adverse effects; D003325:Coronary Care Units; D003362:Cost-Benefit Analysis; D005260:Female; D006440:Hemofiltration / Q000191:economics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D006113:United Kingdom / Q000453:epidemiology