title: Effect of aging on trabecular and compact bone components of proximal and ultradistal radius.
abstract: Bone densitometry has become a major tool for osteoporosis risk assessment. The traditional dual-energy X-ray absorptiometry (DXA) methods are able to evaluate the bone mineral content (BMC; mg/cm) and the areal density (BMD; mg/cm2), but only quantitative computed tomography (QCT) has the potential to measure the true volumetric bone density in the sense of mass per unit volume (mg/cm3). Peripheral QCT (pQCT) measurements were carried out at the nondominant radius using a Stratec XCT 960 (Unitrem, Roma) in 241 postmenopausal and 29 premenopausal women. The sites of evaluation were both the ultradistal and the proximal radius. The technique used has a coefficient of variation of 2% and it allows separation of the bone section into trabecular and cortical bone on the basis of density threshold. Bone mass of radius, hip and spine was also evaluated by DXA procedures. The bone density data obtained by pQCT were significantly correlated with all DXA measurements. The correlation coefficients between their respective BMD values ranged from 0.48 to 0.75, but for the BMC values of the radius the correlation coefficients ranged from 0.82 to 0.93. The BMD values measured by DXA, but not by pQCT, were positively related with patient heights. All pQCT density measurements, including those obtained at the proximal radius and containing exclusively cortical bone, where negatively related with age and years since menopause. A partial volume effect, which is increasingly relevant the thinner are the bone cortices, might explain that. However, by applying increasing density thresholds, cortical bone density seems to decrease with age as a consequence of a gradual density diminution from the inner part of the bone cortex outwards. Trabecular bone density decreases with aging, but its overall mass does not change as a consequence of an age-related enlargement of trabecular area. Thus, the proportion of trabecular bone over total bone rises, and this might be relevant for our understanding of the age-related changes in bone turnover and rate of bone loss.
authors.affiliation: Cattedra di Reumatologia, University of Verona, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Gatti
authors.forename: M
authors.initials: M
authors.lastname: Rossini
authors.forename: N
authors.initials: N
authors.lastname: Zamberlan
authors.forename: V
authors.initials: V
authors.lastname: Braga
authors.forename: E
authors.initials: E
authors.lastname: Fracassi
authors.forename: S
authors.initials: S
authors.lastname: Adami
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D000375:Aging / Q000473:pathology*; D015519:Bone Density; D005260:Female; D006615:Hip / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000503:physiopathology; D015663:Osteoporosis, Postmenopausal / Q000503:physiopathology*; D011884:Radius / Q000473:pathology / Q000502:physiology*; D013131:Spine / Q000502:physiology; D014057:Tomography, X-Ray Computed