3-Acetyl-4-aryl-5-oxo-2,7,7-trimethyl-1,4,5,6,7,8-hexahydro-quinoline derivatives and their calcium antagonistic activities.
Thirteen 3-acetyl-4-aryl-5-oxo-2,7,7-trimethyl-1,4,5,6,7,8- hexahydroquinoline derivatives (5a-m), one of which was synthesized before, have been prepared. The structures of the products 5b-m were characterized by IR,1H-NMR and elemental analysis. The calcium antagonistic activity of these compounds was studied in rabbit taenia coli precontracted with 1 mmol/l Ca+2.
Safak
C
C
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Ozkanli
F
F
Erol
K
K
Aktan
Y
Y
D000818:Animals; D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008970:Molecular Weight; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009529:Nicardipine / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011817:Rabbits
D002121:Calcium Channel Blockers; D011804:Quinolines; D009529:Nicardipine