[Simultaneous allotransplantation of the adrenal gland and the kidney].
Thirteen months after a bilateral nephrectomy for a synchronous bilateral renal cell carcinoma involving both adrenal glands, a 46 years-old man underwent a simultaneous adrenal and kidney allotransplantation. The left renal allograft was harvested together with a ipsilateral adrenal gland using a common aortic patch. Maintenance immunosuppression was based on azathioprine, antilymphocyte globulin cyclosporine and prednisolone. Kidney allograft function remained stable for 5 years until the patient died from multifocal pancreatic metastases. Clinical, biochemical, radiological and histological arguments demonstrated the function of adrenal allograft. To our knowledge, it is the first report of a simultaneous kidney and adrenal gland allotransplantation in a therapeutic intent. An adrenal gland allotransplantation is only justified when the adrenal insufficiency exists with an end stage organ failure requiring transplantation and therefore immunosuppressive drugs.
Dubernard
J M
JM
Service d'Urologie et de Chirurgie de la Transplantation, hôpital E.-Herriot, Lyon.
Cloix
P
P
Feitosa-Tajra
L C
LC
Borson-Chazot
F
F
Bancel
B
B
Baulieux
J
J
Martin
X
X
D000310:Adrenal Gland Neoplasms / Q000556:secondary / Q000601:surgery; D000311:Adrenal Glands / Q000637:transplantation*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D014184:Transplantation, Homologous