[Synergic effect of a teicoplanin and cefpirome combination with aminoglucosides on enterococci. Therapeutic importance].
In this work we have evaluated the in vitro activity of teicoplanin and cefpirome to Enterococcus sp. combined with aminoglycosides gentamicin, tobramycin, netilmicin and amikacin. The combination with a greater percentage of synergy were teicoplanin plus tobramycin (70%), continued by teicoplanin plus gentamicin (69%) and teicoplanin plus netilmicin (58%). The combination of teicoplanin plus aminoglycosides results of great utility in the treatment os serious infections such as endocarditis, meningitis and bacteremia by enterococci, in allergic cases, or resistance to penicillin.
Hoyos López
A
A
Departamento de Microbiología, Hospital Clínco Universitario San Cecilio, Universidad de Granada.
Gutiérrez Fernández
J
J
Piédrola Angulo
G
G
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D016983:Enterococcus / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D017334:Teicoplanin / Q000494:pharmacology*; D000097572:Cefpirome
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D017334:Teicoplanin; D000097572:Cefpirome