Avascular necrosis following extensive chemotherapy and dexamethasone treatment in a patient with advanced ovarian cancer: case report and review of the literature.
Avascular necrosis has long been recognized as a complication of glucorticoid therapy. With the recent recognition of paclitaxel's activity in advanced ovarian cancer, increasing attention has been focused on the concomitant use of corticosteroid premedication and its associated morbidities. This report describes avascular necrosis occurring in a patient receiving chemotherapy with corticosteroid medication for advanced recurrent ovarian cancer.
Gogas
H
H
Gynecological Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Fennelly
D
D
D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D018283:Cystadenocarcinoma, Papillary / Q000188:drug therapy* / Q000473:pathology; D003907:Dexamethasone / Q000009:adverse effects*; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008875:Middle Aged; D018365:Neoplasm, Residual; D010020:Osteonecrosis / Q000139:chemically induced*; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D017239:Paclitaxel / Q000008:administration & dosage
D000893:Anti-Inflammatory Agents; D005047:Etoposide; D003907:Dexamethasone; D003520:Cyclophosphamide; D016190:Carboplatin; D017239:Paclitaxel; D002945:Cisplatin