[Antibiotic-induced prolonged cholestasis: suspected induction by ceftibuten].
We report on a 43-year-old female diabetic patient who was treated with ceftibuten because of Pseudomonas aeruginosa induced otitis externa. Thereafter she developed a prolonged seven-months-persisting irreversible cholestasis. Liver puncutre revealed a canalicular and hepatocellular cholestasis without liver cell necrosis or bile duct injury. After seven-months the patient died because of antibiotic-resistant Pseudomonas-septicemia.
Combe
C
C
Medizinische Poliklinik, Ludwig-Maximilians-Universität München.
Banas
B
B
Zoller
W G
WG
Manns
M P
MP
Schlöndorff
D
D
D000328:Adult; D000077722:Ceftibuten; D018550:Cephalosporin Resistance; D002511:Cephalosporins / Q000009:adverse effects* / Q000627:therapeutic use; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D010032:Otitis Externa / Q000188:drug therapy* / Q000473:pathology; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000473:pathology; D018805:Sepsis / Q000139:chemically induced / Q000473:pathology
D002511:Cephalosporins; D000077722:Ceftibuten