title: Interstitial 9q deletion is associated with CD7+ acute leukemia of myeloid and T lymphoid lineage.
abstract: We report the clinical, hematological and immunophenotypic characteristics from four cases of acute leukemia with interstitial deletion of chromosome 9, ie del(9)(q12-q22), as a single chromosomal abnormality. Three patients had acute myeloblastic leukemia (AML) and one T origin acute lymphoblastic leukemia (ALL). According to FAB classification, blasts were classified as M1 (two patients), M2 (one patient), and L2 (one patient). In two out of three AML cases a myelodysplastic syndrome, one AREB-t and one AREB diagnosed 6 and 11 months before respectively, preceded the onset of AML. Morphological examination showed dysgranulopoiesis, dyserythropoiesis and cytoplasmic vacuoles in two AML patients, while a strong positivity to myeloperoxidases was observed in all AML cases. As concerns immunophenotypic findings, blast cells from two of three AML patients expressed CD7 and CD34, while those from the T-ALL case displayed CD33 and CD34 along with CD7. These observations suggest that del (9q) is associated with CD7+ acute leukemia of myeloid or lymphoid lineage.
authors.forename: F
authors.initials: F
authors.lastname: Ferrara
authors.forename: M
authors.initials: M
authors.lastname: Scognamiglio
authors.forename: R
authors.initials: R
authors.lastname: Di Noto
authors.forename: E M
authors.initials: EM
authors.lastname: Schiavone
authors.forename: V
authors.initials: V
authors.lastname: Poggi
authors.forename: A
authors.initials: A
authors.lastname: Fiorillo
authors.forename: R
authors.initials: R
authors.lastname: Libertini
authors.forename: L
authors.initials: L
authors.lastname: Vicari
authors.forename: L
authors.initials: L
authors.lastname: Del Vecchio
authors.forename: L
authors.initials: L
authors.lastname: Sebastio
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019011:Antigens, CD7 / Q000032:analysis*; D002648:Child; D002872:Chromosome Deletion; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D013601:T-Lymphocytes / Q000648:ultrastructure*
chemical_list: D019011:Antigens, CD7