IL-3 receptor expression, regulation and function in cells of the vasculature.
IL-3 is a haemopoietic growth factor which stimulates the production and functional activity of various blood cell types. Recent evidence suggests that the target cell population of IL-3 is not restricted to haemopoietic cells as previously thought, but vascular cells such as endothelial cells also express receptors for and respond to this cytokine. Interestingly, IL-3 was found to regulate endothelial responses related to inflammation, immunity and haemopoiesis. These findings, summarized in this review, offer new insight into the physiological function of IL-3 and may also be of clinical importance, as IL-3 is used in bone marrow reconstitution following cancer therapy.
Korpelainen
E I
EI
Division of Human Immunology, Hanson Centre for Cancer Research, Adelaide, South Australia.
Gamble
J R
JR
Vadas
M A
MA
Lopez
A F
AF
D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000737:chemistry*; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000378:metabolism; D007371:Interferon-gamma / Q000502:physiology; D007377:Interleukin-3 / Q000502:physiology; D018448:Models, Immunological; D016185:Receptors, Interleukin-3 / Q000096:biosynthesis* / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D007377:Interleukin-3; D016185:Receptors, Interleukin-3; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma