H,K-ATPase.
At least four unique H,K-ATPases have been cloned and are expressed in several tissues. Recent findings have enhanced our appreciation of the roles of H,K-ATPases in the kidney with respect to their molecular identities, functional properties, segmental and intrarenal distribution, and regulatory features. The major role of the H,K-ATPases expressed in mammalian kidney, the gastric and colonic H,K-ATPases, is to regulate potassium and bicarbonate absorption in collecting duct segments.
DuBose
T D
TD
Division of Renal Diseases and Hypertension, University of Texas Medical School-Houston, Houston 77030, USA.
Codina
J
J
D000042:Absorption; D000136:Acid-Base Equilibrium; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D003106:Colon / Q000201:enzymology; D017506:H(+)-K(+)-Exchanging ATPase / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D007668:Kidney / Q000201:enzymology*; D007685:Kidney Tubules, Collecting / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D013270:Stomach / Q000201:enzymology
D001639:Bicarbonates; D007527:Isoenzymes; D012333:RNA, Messenger; D017506:H(+)-K(+)-Exchanging ATPase; D011188:Potassium