Serum soluble CD23 levels in giant cell arteritis.
Lymphocytes and monocytes express various levels of membrane-bound CD23, the low affinity receptor for IgE (Fc epsilon RII), and in some cases release it as a soluble form. Soluble CD23 (sCD23) has been implicated in the regulation of many immunological functions of T and B lymphocytes, macrophages and myeloid cells in humans. To study serum sCD23 levels in inflammatory conditions, we selected a systemic disease sensitive to corticotherapy, the giant cell arteritis, which is characterized by an inflammation of the temporal artery. Serum sCD23 levels, as measured by a radioimmunoassay, were increased in these patients, and returned to normal values within the 24 h following initiation of corticotherapy. The data suggest that the increase in sCD23 levels in giant cell arteritis results from an overproduction.
Roblot
P
P
Service de Medicine Interne, Chu la Miletrie, Poitiers, France.
Morel
F
F
Lelièvre
E
E
Biais-Sauvètre
M H
MH
de Groote
D
D
Preud'homme
J L
JL
Lecron
J C
JC
D013700:Giant Cell Arteritis / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D011241:Prednisone / Q000627:therapeutic use*; D017455:Receptors, IgE / Q000097:blood*; D012995:Solubility
D017455:Receptors, IgE; D011241:Prednisone