Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene.
The rat gene Leucine-Rich Primary Response Gene-1 (LRPR1) has been proposed to encode a protein involved in the response of gonadal tissues to follicle-stimulating hormone. We have characterized a human transcript that probably encodes the orthologue of the rat protein, exhibiting 72% identity at the amino acid level. The gene from which the transcript is derived maps to human chromosomal region Xq22 and therefore becomes a potential candidate for human X-linked disorders of gonadal development.
Roberts
R G
RG
Department of Medical Genetics, Addenbrooke's Hospital, Cambridge, United Kingdom. rroberts@hgmp.mrc.ac.uk
Kendall
E
E
Vetrie
D
D
Bobrow
M
M
D000595:Amino Acid Sequence; D000818:Animals; D002874:Chromosome Mapping; D004268:DNA-Binding Proteins / Q000235:genetics*; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D006801:Humans; D016350:Leucine Zippers; D008969:Molecular Sequence Data; D051381:Rats; D017386:Sequence Homology, Amino Acid
C484297:CENPI protein, human; C093717:Cenpi protein, rat; D004268:DNA-Binding Proteins; D005640:Follicle Stimulating Hormone