[Viral hepatitis B and C in patients with acute leukemias].
Enzyme immunoassay has been used in 102 patients with acute leukemia (AL) and 340 donors to identify serological markers of hepatitis B virus (HBV) and hepatitis C virus (HCV): HB-sAg, anti-HBs, anti-HBc, anti-HBc IgM, HBeAg, anti-HBe. At the moment of AL diagnosis in 50 patients with acute myeloid leukemia and in 28 patients with acute lymphoblastic leukemia at least one HBV marker was found in 68% and 71%, respectively, HBsAg in 12% of patients with AML and 25% of those with ALL. In remission maintenance, HBsAg was registered in 83% of patients with AML and 44% of those with ALL. Anti-HCV in diagnosis of acute leukemia were detected in 1.28% of patients, 12 months after in 40% with ALL and 67% with AML. In examination of the donors at least one HBV marker was found in 36%, HBsAg in 2.1%, anti-HCV in 1.86% of the examinees. It is inferred that acute leukemia patients are often infected with HBV and in long-term follow-up demonstrate reactivation of viral infection, though infection with mutant B viruses is also possible. HCV is a main cause of posttransfusion hepatitis in this group of patients.
Konstantinova
T S
TS
Shalaev
V A
VA
Shpeer
E L
EL
Terskikh
V A
VA
Nizhechik
Iu S
IuS
D000293:Adolescent; D000328:Adult; D000368:Aged; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001782:Blood Donors; D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000175:diagnosis*; D006510:Hepatitis B Antibodies / Q000097:blood; D006526:Hepatitis C / Q000097:blood / Q000175:diagnosis*; D018937:Hepatitis C Antibodies / Q000097:blood; D006529:Hepatomegaly / Q000097:blood / Q000175:diagnosis; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000175:diagnosis*; D000637:Transaminases / Q000097:blood
D015415:Biomarkers; D006510:Hepatitis B Antibodies; D018937:Hepatitis C Antibodies; D000637:Transaminases; D001663:Bilirubin