Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV.
Four virus proteins similar to two human macrophage inflammatory protein (MIP) chemokines, interleukin-6 (IL-6), and interferon regulatory factor (IRF) are encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) genome. vIL-6 was functional in B9 proliferation assays and primarily expressed in KSHV-infected hematopoietic cells rather than KS lesions. HIV-1 transmission studies showed that vMIP-I is similar to human MIP chemokines in its ability to inhibit replication of HIV-1 strains dependent on the CCR5 co-receptor. These viral genes may form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions.
Moore
P S
PS
School of Public Health, Columbia University, New York, NY 10032, USA.
Boshoff
C
C
Weiss
R A
RA
Chang
Y
Y
D000595:Amino Acid Sequence; D000818:Animals; D002455:Cell Division; D002460:Cell Line; D054407:Chemokine CCL4; D015870:Gene Expression; D005814:Genes, Viral; D015497:HIV-1 / Q000502:physiology; D004854:Herpesvirus 4, Human / Q000502:physiology; D019288:Herpesvirus 8, Human / Q000235:genetics* / Q000502:physiology; D006801:Humans; D015850:Interleukin-6 / Q000737:chemistry / Q000235:genetics; D008198:Lymph Nodes / Q000821:virology; D016393:Lymphoma, B-Cell / Q000821:virology; D019402:Macrophage Inflammatory Proteins / Q000737:chemistry / Q000235:genetics; D051379:Mice; D018716:Molecular Mimicry; D008969:Molecular Sequence Data; D019713:Receptors, CCR5; D018121:Receptors, Cytokine / Q000378:metabolism; D015728:Receptors, HIV / Q000378:metabolism; D012514:Sarcoma, Kaposi / Q000821:virology; D016415:Sequence Alignment; D015398:Signal Transduction; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D017361:Viral Nonstructural Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D014779:Virus Replication
D054407:Chemokine CCL4; D015850:Interleukin-6; D019402:Macrophage Inflammatory Proteins; D019713:Receptors, CCR5; D018121:Receptors, Cytokine; D015728:Receptors, HIV; D017361:Viral Nonstructural Proteins; D013755:Tetradecanoylphorbol Acetate