title: Changes in protein turnover and resting energy expenditure after treatment of malaria in Gambian children.
abstract: To explore the changes in resting energy expenditure (REE) and whole body protein turnover induced by malaria, 23 children aged 6 to 14 y (23.9 +/- 1.0 kg, 1.3 +/- 0.02 m) were studied on three separate days after treatment (d 1, d 2, and 15 d later). REE was assessed by indirect calorimetry (hood), whereas whole body protein turnover was estimated using a single dose of [15N]glycine administered p.o. by measuring the isotopic enrichment of [15N]ammonia in urine over 12 h. Within the first 3.5 h after treatment, the body temperature dropped from 39.8 +/- 0.1 to 37.8 +/- 0.1 degrees C (p < 0.0001), and REE followed the same pattern, decreasing rapidly from 223 +/- 6 to 187 +/- 4 kJ/kg/d (p < 0.0001). Whole body protein synthesis and breakdown were significantly higher during the 1st day (5.65 +/- 0.38 and 6.21 +/- 0.43 g/kg/d, respectively) than at d 15 (2.95 +/- 0.17 and 2.77 +/- 0.2 g/kg/d). It is concluded that Gambian children suffering from an acute episode of malaria have an increased REE averaging 37% of the control value (d 15) and that this was associated with a substantial increase (by a factor of 2) in whole body protein turnover. A rapid normalization of the hypermetabolism and protein hypercatabolism states after treatment was observed.
authors.affiliation: Institute of Physiology, Faculty of Medicine, University of Lausanne, Switzerland.
authors.forename: P Y
authors.initials: PY
authors.lastname: Berclaz
authors.forename: C
authors.initials: C
authors.lastname: Benedek
authors.forename: E
authors.initials: E
authors.lastname: Jequier
authors.forename: Y
authors.initials: Y
authors.lastname: Schutz
mesh_terms: D000082:Acetaminophen / Q000494:pharmacology*; D000293:Adolescent; D015992:Body Mass Index; D001831:Body Temperature; D001835:Body Weight; D002648:Child; D002738:Chloroquine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004734:Energy Metabolism; D005714:Gambia; D006339:Heart Rate; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D011506:Proteins / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D011506:Proteins; D000082:Acetaminophen; C023676:chloroquine diphosphate; D002738:Chloroquine