The influence of long-lasting implantation on the function of phagocytes towards staphylococci.
A mouse model of peritoneal staphylococcal infection in mice implanted with heparinized polyethylene (H-PE) was used in this study. The binding of staphylococci and fibronectin (Fn) to biomaterial surface was estimated in vitro and in vivo. The activity of phagocytes from the animals non-implanted or implanted for 7 days or 2 months with H-PE was determined on the basis of bactericidal activity, nitric oxide (NO) and Fn production.
Rózalska
B
B
Department of Infectious Biology, University of Lódź, Poland.
Burow
A
A
Ljungh
A
A
Rudnicka
W
W
D000818:Animals; D001672:Biocompatible Materials; D002448:Cell Adhesion; D002478:Cells, Cultured; D005353:Fibronectins / Q000096:biosynthesis / Q000378:metabolism; D006098:Granulocytes; D006493:Heparin; D051379:Mice; D008811:Mice, Inbred DBA; D009569:Nitric Oxide / Q000096:biosynthesis; D010538:Peritonitis / Q000276:immunology* / Q000378:metabolism; D010586:Phagocytes / Q000276:immunology*; D011095:Polyethylenes; D019736:Prostheses and Implants; D013203:Staphylococcal Infections / Q000276:immunology* / Q000378:metabolism; D013211:Staphylococcus aureus; D013212:Staphylococcus epidermidis
D001672:Biocompatible Materials; D005353:Fibronectins; D011095:Polyethylenes; D009569:Nitric Oxide; D006493:Heparin