title: Serological profiles of hepatitis B carrier patients in Singapore with special reference to the frequency and significance of concurrent presence of HBsAg and anti-HBs.
abstract: Hepatitis B serological markers were investigated in 1,132 consecutive Singaporean HBV carriers. Hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (anti-HBs) were found concurrently in 234 carriers (234/1132 or 21%). Serum anti-HBs levels were more than 10 mIU/mL in 80 of these carriers (80/234 or 34%). There were no difference in HBeAg positive status, as well as HBV-DNA positive status in concurrent HBsAg/anti-HBs carriers compared to carriers without anti-HBs. Our results suggested that concurrent HBsAg and anti-HBs is a common serologic pattern in Singaporean HBV carriers.
authors.affiliation: Department of Medicine National University of Singapore, Singapore.
authors.forename: Y M
authors.initials: YM
authors.lastname: Wang
authors.forename: W C
authors.initials: WC
authors.lastname: Ng
authors.forename: J Y
authors.initials: JY
authors.lastname: Kang
authors.forename: I
authors.initials: I
authors.lastname: Yap
authors.forename: B L
authors.initials: BL
authors.lastname: Seet
authors.forename: J
authors.initials: J
authors.lastname: Teo
authors.forename: R
authors.initials: R
authors.lastname: Smith
authors.forename: R
authors.initials: R
authors.lastname: Guan
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002353:Carrier State / Q000453:epidemiology / Q000276:immunology*; D002648:Child; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D012698:Serologic Tests; D012846:Singapore
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens