title: [Genomic instability after exposure to radiation at low doses (in the 10-kilometer zone of the accident at the Chernobyl Atomic Electric Power Station and under laboratory conditions)].
abstract: The results of series investigations of late effects after Chernobyl accident are discussed. Genomic instability induced by chronic irradiation of cultural cells in Chernobyl zone and in laboratory conditions have been studied. It was shown that low level prolonged irradiation result in increase of frequency of cells with micronuclei, giant cells, enhancement of radiosensitivity in descendents of early irradiated cells. Chronic low doses irradiation doesn't induce the adaptive response. Comparative investigation of adaptive response in blood lymphocytes of people (adults and children) living in Moscow and in regions polluted with radionuclides (5-40 ci/km2) after Chernobyl disaster have been conducted. In population from contaminated areas the frequency of individuals with definite adaptive response is decreased and there are individuals with increasing radiosensitivity after irradiation in conditioned dose. Chronic irradiation during living on contaminated areas don't induce the adaptive response.
authors.forename: I I
authors.initials: II
authors.lastname: Pelevina
authors.forename: V Ia
authors.initials: VIa
authors.lastname: Gotlib
authors.forename: O V
authors.initials: OV
authors.lastname: Kudriashova
authors.forename: A M
authors.initials: AM
authors.lastname: Serebrianyĭ
authors.forename: G G
authors.initials: GG
authors.lastname: Afanas'ev
mesh_terms: D000222:Adaptation, Physiological / Q000528:radiation effects; D000818:Animals; D006224:Cricetinae; D003412:Cricetulus; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D015894:Genome, Human; D006367:HeLa Cells; D006801:Humans; D008214:Lymphocytes / Q000502:physiology / Q000528:radiation effects*; D015162:Micronucleus Tests; D011210:Power Plants; D011836:Radiation Tolerance; D018788:Radioactive Hazard Release; D012426:Russia; D013997:Time Factors; D014455:Ukraine