RNA turnover and the control of mitochondrial gene expression.
Recent evidence suggests that RNA turnover in yeast mitochondria is important, not only to regulate RNA abundance, but also to facilitate group I intron splicing and suppress the potentially toxic effect of high levels of excised group I intron RNAs. Protein-assisted splicing of group I introns requires that splicing factors are 'actively' recycled, because of their tight binding to the intron RNA. The putative NTP-dependent RNA helicase Suv3p might promote this recycling and, at the same time, suppress intron overaccumulation because of the functional association of this protein with mtEXO, a novel 3'-5' exoribonuclease that can degrade excised group I intron RNAs.
Margossian
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SP
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235, USA.
Butow
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RA
D053487:DEAD-box RNA Helicases; D005656:Fungal Proteins / Q000378:metabolism; D005786:Gene Expression Regulation / Q000235:genetics*; D005800:Genes, Fungal / Q000235:genetics; D007700:Kinetics; D008928:Mitochondria / Q000378:metabolism*; D008957:Models, Genetic; D012313:RNA / Q000378:metabolism*; D020365:RNA Helicases; D012316:RNA Nucleotidyltransferases / Q000378:metabolism; D012326:RNA Splicing / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins; D015003:Yeasts / Q000378:metabolism
D005656:Fungal Proteins; D029701:Saccharomyces cerevisiae Proteins; D012313:RNA; D012316:RNA Nucleotidyltransferases; C075918:SUV3 protein, S cerevisiae; D053487:DEAD-box RNA Helicases; D020365:RNA Helicases