[Prenatal study of hypertrophic cardiomyopathy and its association with insulin levels in fetuses of diabetic mothers].
OBJECTIVE
To test the hypothesis that hypertrophic cardiomyopathy during prenatal life in diabetic pregnancies is related to fetal hyperinsulinism.


METHODS
Thirty seven fetuses of diabetic mothers and 28 of non-diabetic mothers were studied by echocardiography and fetal insulin levels measured.


RESULTS
Mean fetal insulin levels were 22.16 (+/- 44.25) microU/ml (3.20 to 240 microU/ml) in the group with diabetes and 6.50 (+/- 3.45) microU/ml (3.10 to 17.00 microU/ml) in the control group (p = 0.004). Ten out of 37 fetuses of the diabetic group were considered to have hypertrophic cardiomyopathy (27.02%), while none of the fetuses of the control group showed increase in septal thickness (p = 0.001). A significant association between prenatal hypertrophic cardiomyopathy and fetal hyperinsulinism was demonstrated (p = 0.013).


CONCLUSIONS
There is an association between hypertrophic cardiomyopathy and high levels of fetal insulin.
Hagemann
L L
LL
Instituto de Cardiologia do RS--Unidade de Pesquisa, Porto Alegre, RS.
Zielinsky
P
P
D000328:Adult; D000649:Amniocentesis; D002312:Cardiomyopathy, Hypertrophic / Q000209:etiology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications*; D007231:Infant, Newborn; D007328:Insulin / Q000032:analysis*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000150:complications*; D011296:Prenatal Diagnosis; D015995:Prevalence; D012044:Regression Analysis
D007328:Insulin