Interstitial 9q deletion is associated with CD7+ acute leukemia of myeloid and T lymphoid lineage.
We report the clinical, hematological and immunophenotypic characteristics from four cases of acute leukemia with interstitial deletion of chromosome 9, ie del(9)(q12-q22), as a single chromosomal abnormality. Three patients had acute myeloblastic leukemia (AML) and one T origin acute lymphoblastic leukemia (ALL). According to FAB classification, blasts were classified as M1 (two patients), M2 (one patient), and L2 (one patient). In two out of three AML cases a myelodysplastic syndrome, one AREB-t and one AREB diagnosed 6 and 11 months before respectively, preceded the onset of AML. Morphological examination showed dysgranulopoiesis, dyserythropoiesis and cytoplasmic vacuoles in two AML patients, while a strong positivity to myeloperoxidases was observed in all AML cases. As concerns immunophenotypic findings, blast cells from two of three AML patients expressed CD7 and CD34, while those from the T-ALL case displayed CD33 and CD34 along with CD7. These observations suggest that del (9q) is associated with CD7+ acute leukemia of myeloid or lymphoid lineage.
Ferrara
F
F
Scognamiglio
M
M
Di Noto
R
R
Schiavone
E M
EM
Poggi
V
V
Fiorillo
A
A
Libertini
R
R
Vicari
L
L
Del Vecchio
L
L
Sebastio
L
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D019011:Antigens, CD7 / Q000032:analysis*; D002648:Child; D002872:Chromosome Deletion; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D013601:T-Lymphocytes / Q000648:ultrastructure*
D019011:Antigens, CD7