The efficacy and memory effects of oral triazolam premedication in highly anxious dental patients.
Triazolam (0.375 or 0.50 mg) or placebo was administered orally to 31 highly anxious dental patients in a double-blind clinical trial 1 hr before treatment. The drug was safe and highly effective, in comparison to placebo, in reducing both anxious cognitions and disruptive movement during oral injections of local anesthetic and drilling. Episodic memory and implicit memory were both adversely affected by the active drug but not the placebo.
Milgrom
P
P
Department of Dental Public Health Sciences, University of Washington, Seattle 98195-7475, USA.
Quarnstrom
F C
FC
Longley
A
A
Libed
E
E
D000284:Administration, Oral; D000328:Adult; D016009:Chi-Square Distribution; D016854:Dental Anxiety / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D016015:Logistic Models; D008297:Male; D008568:Memory / Q000187:drug effects*; D008875:Middle Aged; D011229:Preanesthetic Medication; D018709:Statistics, Nonparametric; D014229:Triazolam / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D006993:Hypnotics and Sedatives; D014229:Triazolam