title: Effect of interval from fetal corticosteriod treatment to delivery on postnatal lung function of preterm lambs.
abstract: The effect of altering the interval from treatment to delivery on postnatal lung function of the preterm lamb is unknown. We treated groups of 8-10 singleton fetal sheep with 0.5 mg/kg betamethasone by fetal injection and evaluated postnatal lung function 40 min after preterm delivery at 123 days gestation 2 days after treatment or at 128 days gestation 2, 4, and 7 days after treatment relative to groups of 4-8 saline-injected control animals. At 123 days, betamethasone significantly improved arterial PCO2, dynamic thoracic compliance, and ventilatory efficiency index and doubled lung gas volume relative to a control group. Fetal treatment with betamethasone 2, 4, or 7 days before delivery at 128 days also improved these same indicators of lung function relative to controls, and the magnitude of the improvements was the same for all indicators and independent of treatment-to-delivery interval. Betamethasone suppressed the normal postnatal increase in plasma cortisol after 2 and 4 days of exposure but not after 7 days of exposure. Betamethasone also increased fetal and postnatal triiodothyronine concentrations after 2 days of exposure but not at 4 or 7 days of exposure. Although the hormone effects were transient, postnatal lung functional responses to betamethasone persisted over the 2- to 7-day interval from treatment to delivery.
authors.affiliation: Perinatal Laboratories, Harbor-University of California, Los Angeles Medical Center, Torrance 90502, USA.
authors.forename: M
authors.initials: M
authors.lastname: Ikegami
authors.forename: D H
authors.initials: DH
authors.lastname: Polk
authors.forename: A H
authors.initials: AH
authors.lastname: Jobe
authors.forename: J
authors.initials: J
authors.lastname: Newnham
authors.forename: P
authors.initials: P
authors.lastname: Sly
authors.forename: R
authors.initials: R
authors.lastname: Kohan
authors.forename: R
authors.initials: R
authors.lastname: Kelly
mesh_terms: D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001623:Betamethasone / Q000494:pharmacology; D001784:Blood Gas Analysis; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology; D006728:Hormones / Q000097:blood; D006854:Hydrocortisone / Q000494:pharmacology; D008168:Lung / Q000196:embryology / Q000254:growth & development / Q000502:physiology*; D008170:Lung Compliance / Q000502:physiology; D008176:Lung Volume Measurements; D009929:Organ Size / Q000502:physiology; D011247:Pregnancy; D011650:Pulmonary Alveoli / Q000378:metabolism; D012129:Respiratory Function Tests; D012756:Sheep; D013997:Time Factors
chemical_list: D000305:Adrenal Cortex Hormones; D005938:Glucocorticoids; D006728:Hormones; D001623:Betamethasone; D006854:Hydrocortisone