[Genetic risks associated with intracytoplasmic sperm injection].
Preliminary data available for ICSI demonstrate an increased incidence of chromosome abnormalities in infertile men, their spermatozoa and in the preimplantation embryos obtained after microinjection. The injection itself may not result in a significant increase in damage to the meiotic spindle provided care is taken to orient the polar body away to the site of injection. It is therefore of paramount importance to continue all investigations on larger series to properly evaluate the safety of the ICSI procedure.
Plachot
M
M
Laboratoire de Recherche en Fécondation in Vitro et Biologie de la Reproduction, Hôpital Necker, Paris.
D002869:Chromosome Aberrations / Q000209:etiology*; D025063:Chromosome Disorders; D005307:Fertilization in Vitro / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D007246:Infertility / Q000150:complications / Q000628:therapy; D008297:Male; D008845:Microinjections / Q000009:adverse effects*; D012307:Risk Factors; D013094:Spermatozoa