Effects of brain natriuretic peptide on effects of morphine in mice.
Brain natriuretic peptide (BNP) is a member of the natriuretic peptide family. The effects of intracerebroventricularly administered BNP (in 0.002-200 ng doses) on the analgesic, tolerance-inducing and dependence-inducing actions of morphine were investigated in adult male CFLP mice. Graded doses of BNP centrally did not affect pain sensitivity itself in a tail-flick test. However, different doses of BNP depressed the acute nociceptive effect of a single subcutaneous dose of morphine (5 mg/kg), and BNP attenuated the development of acute and chronic tolerance to morphine. Withdrawal signs were studied by injecting naloxone (1 mg/kg s.c.). There was no significant difference in symptoms between the tolerant group and animals treated with BNP. The data obtained indicate that BNP can modify the analgesic action of morphine.
Babarczy
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Department of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Vízi
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Z
Szabó
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Telegdy
G
G
D000700:Analgesics / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D000818:Animals; D004343:Drug Implants; D004361:Drug Tolerance; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009020:Morphine / Q000008:administration & dosage / Q000633:toxicity*; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology*; D020097:Natriuretic Peptide, Brain; D009419:Nerve Tissue Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D010147:Pain Measurement; D019966:Substance-Related Disorders / Q000188:drug therapy*
D000700:Analgesics; D004343:Drug Implants; D009419:Nerve Tissue Proteins; D020097:Natriuretic Peptide, Brain; D009270:Naloxone; D009020:Morphine