title: RNA turnover and the control of mitochondrial gene expression.
abstract: Recent evidence suggests that RNA turnover in yeast mitochondria is important, not only to regulate RNA abundance, but also to facilitate group I intron splicing and suppress the potentially toxic effect of high levels of excised group I intron RNAs. Protein-assisted splicing of group I introns requires that splicing factors are 'actively' recycled, because of their tight binding to the intron RNA. The putative NTP-dependent RNA helicase Suv3p might promote this recycling and, at the same time, suppress intron overaccumulation because of the functional association of this protein with mtEXO, a novel 3'-5' exoribonuclease that can degrade excised group I intron RNAs.
authors.affiliation: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235, USA.
authors.forename: S P
authors.initials: SP
authors.lastname: Margossian
authors.forename: R A
authors.initials: RA
authors.lastname: Butow
mesh_terms: D053487:DEAD-box RNA Helicases; D005656:Fungal Proteins / Q000378:metabolism; D005786:Gene Expression Regulation / Q000235:genetics*; D005800:Genes, Fungal / Q000235:genetics; D007700:Kinetics; D008928:Mitochondria / Q000378:metabolism*; D008957:Models, Genetic; D012313:RNA / Q000378:metabolism*; D020365:RNA Helicases; D012316:RNA Nucleotidyltransferases / Q000378:metabolism; D012326:RNA Splicing / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins; D015003:Yeasts / Q000378:metabolism
chemical_list: D005656:Fungal Proteins; D029701:Saccharomyces cerevisiae Proteins; D012313:RNA; D012316:RNA Nucleotidyltransferases; C075918:SUV3 protein, S cerevisiae; D053487:DEAD-box RNA Helicases; D020365:RNA Helicases