Drug-related killings: a case of mistaken identity.
Abortive attempts at DNA repair can contribute to the effects of DNA damage inflicted by cytotoxic drugs. DNA methylation damage, 6-thioguanine and cisplatin adducts all owe their cytotoxicity in part to the intervention of DNA mismatch repair.
Karran
P
P
Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms Herts., UK.
Bignami
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002945:Cisplatin / Q000494:pharmacology; D019175:DNA Methylation; D004260:DNA Repair; D006801:Humans; D015122:Mercaptopurine / Q000494:pharmacology; D013866:Thioguanine / Q000494:pharmacology
D000970:Antineoplastic Agents; D015122:Mercaptopurine; D013866:Thioguanine; D002945:Cisplatin