Anticonvulsant action of metabotropic glutamate receptor agonists in kindled amygdala of rats.
1S,3R-1-Aminocyclopentane-1,3-dicarboxylate (1S,3R-ACPD) and L-2-amino-4-phosphonobutyrate (L-AP4) are selective agonists of metabotropic glutamate receptors (mGluRs). 1S,3R-ACPD (200 nmol) injected into the amygdala (AM) of non-kindled rats produced immediate and transient seizures, characterized by immobility, searching, and wet-dog shakes. However, this ictal response was not observed in AM-kindled rats. Intra-AM injection of 1S,3R-ACPD (40 or 200 nmol) or L-AP4 (200 nmol) resulted in a delayed and marked suppression of kindled seizures, 3 days after 40 nmol of 1S,3R-ACPD, 1 day after 200 nmol of 1S,3R-ACPD, and from 1 to 3 days after 200 nmol of L-AP4. These and the previous findings suggest that: (1) the excitatory action of 1S,3R-ACPD in the AM, which may be mediated by the postsynaptic mGluRs, is reduced after completion of kindling; (2) 1S,3R-ACPD and L-AP4 exert anti-convulsant action in the AM, presumably by activating the presynaptic as well as postsynaptic mGluRs.
Suzuki
K
K
Department of Neuropsychiatry, Fukushima Medical College, Japan.
Mori
N
N
Kittaka
H
H
Iwata
Y
Y
Yamada
Y
Y
Osonoe
K
K
Niwa
S
S
D000613:Aminobutyrates / Q000494:pharmacology; D000679:Amygdala / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D003515:Cycloleucine / Q000031:analogs & derivatives / Q000494:pharmacology; D004569:Electroencephalography / Q000187:drug effects; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D007267:Injections; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists*
D000613:Aminobutyrates; D000927:Anticonvulsants; D018690:Excitatory Amino Acid Agonists; D018094:Receptors, Metabotropic Glutamate; D003515:Cycloleucine; C036361:1-amino-1,3-dicarboxycyclopentane; C012729:2-amino-4-phosphonobutyric acid