Dimorphic expression of calbindin-D28K in the medial basal hypothalamus from perinatal male and female rats.
Developmental expression of calbindin-D28K (CALB) in the medial basal hypothalamic (MBH) and amygdaloid (AMY) regions was examined by Western analysis. Males displayed significantly higher CALB levels compared to females in the MBH (but not the AMY) from gestational day 17 through postnatal day 1. These data imply that androgens or other hormonal factors regulate MBH CALB expression which in turn may modulate sexually dimorphic brain structures by preventing cell loss during neuronal development.
Lephart
E D
ED
Department of Zoology, Brigham Young University, Provo, UT 84602, USA. EDLEPHAR@ACD1.BYU.EDU
D000679:Amygdala / Q000378:metabolism*; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D015153:Blotting, Western; D064092:Calbindin 1; D064026:Calbindins; D005314:Embryonic and Fetal Development / Q000502:physiology; D005260:Female; D005865:Gestational Age; D007033:Hypothalamus, Middle / Q000378:metabolism*; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D064030:S100 Calcium Binding Protein G / Q000096:biosynthesis*; D012727:Sex Characteristics
C576500:Calb1 protein, rat; D064092:Calbindin 1; D064026:Calbindins; D009419:Nerve Tissue Proteins; D064030:S100 Calcium Binding Protein G