title: Elevation of either axoplasmic norepinephrine or sodium level induced release of norepinephrine from cardiac sympathetic nerve terminals.
abstract: Using dialysis technique, prominent accumulation of norepinephrine (NE) in the myocardial interstitial space was observed under two different conditions: (1) local administration of a monoamine oxidase inhibitor (pargyline, 1, 10 mM), (2) local administration of a Na, K-ATPase inhibitor (ouabain, 10, 100 microM). Further, pretreatment with a vesicle uptake inhibitor (reserpine, 10 microM) augmented these responses. Either condition independently caused endogenous NE release and a brisk increase in dialysate NE levels might occur as a consequence of non-exocytotic release of NE.
authors.affiliation: Department of Cardiac Physiology, National Cardiovascular Center Research Institute, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamazaki
authors.forename: T
authors.initials: T
authors.lastname: Akiyama
authors.forename: H
authors.initials: H
authors.lastname: Kitagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Takauchi
authors.forename: T
authors.initials: T
authors.lastname: Kawada
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001369:Axons / Q000737:chemistry / Q000378:metabolism*; D002316:Cardiotonic Agents / Q000494:pharmacology; D002415:Cats; D005089:Exocytosis / Q000502:physiology; D005260:Female; D005728:Ganglia, Sympathetic / Q000187:drug effects / Q000201:enzymology*; D006321:Heart / Q000294:innervation; D008297:Male; D017551:Microdialysis; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism*; D010042:Ouabain / Q000494:pharmacology; D010293:Pargyline / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
chemical_list: D000959:Antihypertensive Agents; D002316:Cardiotonic Agents; D008996:Monoamine Oxidase Inhibitors; D010042:Ouabain; D012110:Reserpine; D010293:Pargyline; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D009638:Norepinephrine