title: Occupational and environmental influences on scleroderma.
abstract: This article has reviewed available data on the environmental agents, including occupational factors, that might influence susceptibility to scleroderma. None of the exposures considered could act independently in causing the disease and individually would only be responsible for a small proportion of cases. Nonetheless, they do provide useful insight into the possible mechanisms of disease causation.
authors.affiliation: ARC Epidemiology Research Unit, University of Manchester, United Kingdom.
authors.forename: A J
authors.initials: AJ
authors.lastname: Silman
authors.forename: M C
authors.initials: MC
authors.lastname: Hochberg
mesh_terms: D018427:Breast Implants / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D004391:Dust / Q000009:adverse effects; D004781:Environmental Exposure / Q000009:adverse effects; D006801:Humans; D016273:Occupational Exposure / Q000009:adverse effects; D012307:Risk Factors; D012595:Scleroderma, Systemic / Q000453:epidemiology / Q000209:etiology*; D012822:Silicon Dioxide / Q000009:adverse effects; D012826:Silicone Elastomers / Q000009:adverse effects; D012997:Solvents / Q000009:adverse effects
chemical_list: D004391:Dust; D012826:Silicone Elastomers; D012997:Solvents; D012822:Silicon Dioxide