title: 99mTechnetium-stannous oxinate as marker of liposome formulations.
abstract: Liposomes associated with tin(II) dioxinate were prepared from egg yolk phosphatidylcholine and cholesterol as sterile and pyrogen-free multilamellar or unilamellar vesicles. Complexing of liposomal tin(II) dioxinate with 99mTc attained 98% of the added radioactivity. Thirty percent 99mTc were released during 24-h incubation in biological fluids. The absence of tin colloids seen by electron microscopy and the stability of liposomal phospholipid and tin(II) dioxinate during 72-h incubation at 37 degrees C in plasma and cerebrospinal fluid would allow safe and reliable scintigraphic liposome pharmacokinetic studies.
authors.affiliation: Department of Anesthesiology, Flemish Free University of Brussels Medical Center, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Alafandy
authors.forename: G
authors.initials: G
authors.lastname: Goffinet
authors.forename: V
authors.initials: V
authors.lastname: Umbrain
authors.forename: J
authors.initials: J
authors.lastname: D'Haese
authors.forename: F
authors.initials: F
authors.lastname: Camu
authors.forename: F J
authors.initials: FJ
authors.lastname: Legros
mesh_terms: D002784:Cholesterol; D003102:Colloids; D004146:Dioxanes; D004337:Drug Carriers; D005613:Freeze Etching; D006801:Humans; D008081:Liposomes; D008244:Lysophosphatidylcholines; D008854:Microscopy, Electron; D015609:Organotechnetium Compounds / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D009947:Organotin Compounds / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D010713:Phosphatidylcholines; D011877:Radionuclide Imaging; D015203:Reproducibility of Results; D013997:Time Factors
chemical_list: D003102:Colloids; D004146:Dioxanes; D004337:Drug Carriers; D008081:Liposomes; D008244:Lysophosphatidylcholines; D015609:Organotechnetium Compounds; D009947:Organotin Compounds; D010713:Phosphatidylcholines; C105028:technetium Tc 99m stannous oxinate; C105027:tin(II) dioxinate; D002784:Cholesterol