Coding of odour intensity in a sensory neuron.
A deterministic biophysical model of an olfactory sensory neuron under constant stimulation is presented with the aim of describing the successive conversion steps, including receptor activation, conductance change, receptor potential and firing frequency, that are involved in the coding of odorant concentration. This model is divided in two parts. The odorant-sensitive part (OSP), consisting of one cylindrical dendrite, is connected to the odorant-insensitive part (OIP), corresponding to passive dendrite, soma and axon. Each part exerts a specific effect on the coding properties of the conversion steps, i.e. their magnitude, sensitivity and dynamic range. The maximum conductance of the OSP affects positively all coding properties whereas the input resistance of the OIP, which depends on its size and shape, affects positively the sensitivity and negatively the dynamic range. These findings are helpful for understanding the input-output properties of many types of neurons.
Vermeulen
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Laboratoire de Biométrie, Institut National de la Recherche Agronomique, Versailles, France.
Lánský
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P
Tuckwell
H
H
Rospars
J P
JP
D000200:Action Potentials / Q000502:physiology; D008954:Models, Biological; D009475:Neurons, Afferent / Q000502:physiology*; D009812:Odorants; D018035:Receptors, Odorant / Q000502:physiology; D012680:Sensitivity and Specificity; D015398:Signal Transduction / Q000502:physiology; D012903:Smell / Q000502:physiology*
D018035:Receptors, Odorant