[The characteristics of oxolinic acid transport in the blood of dogs and monkeys when administered intramuscularly and perorally].
A possibility of testing oxolynic acid (OA) transport in blood of animals by its bactericidal effect was studied experimentally on macaques and non-pedigree dogs (intramuscular and peroral administration). Kinetics of accumulation and elimination of OA and its derivatives exhibiting bactericidal effect makes it possible to predict optimum scheme of using these drugs in prevention and treatment of radiation disease.
Tarkil
N Z
NZ
Iartsev
E I
EI
Novosel'tseva
S D
SD
Barkaia
V S
VS
Nazarov
S M
SM
Znamenskiĭ
V V
VV
D000284:Administration, Oral; D000818:Animals; D001692:Biological Transport; D001770:Blood Bactericidal Activity / Q000187:drug effects; D002214:Capsules; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli; D007273:Injections, Intramuscular; D008253:Macaca mulatta; D010093:Oxolinic Acid / Q000008:administration & dosage / Q000097:blood*; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013535:Suspensions; D013997:Time Factors
D002214:Capsules; D011837:Radiation-Protective Agents; D013535:Suspensions; D010093:Oxolinic Acid
Osobennosti transporta oksolinovoĭ kisloty v krovi u sobak i obez'ian pri vmutrimyshechnom i peroral'nom vvedenii.