title: Larvicidal activity of the naphthylisoquinoline alkaloid dioncophylline A against the malaria vector Anopheles stephensi.
abstract: The larvicidal activity of dionocophylline A, a naphthylisoquinoline alkaloid derived from the tropical vine Triphyophyllum peltatum (Dioncophyllaceae), was investigated against the malaria vector Anopheles stephensi. In direct and indirect inhibition assays it was demonstrated that the younger larval stages were very sensitive towards this natural product, with LC50 values below 1 mg/l. Pronounced effects were observed within 4 h of exposure. Aging larvae, however, were less sensitive, while pupae were totally insensitive to the action of dioncophylline A. The transformations from larvae to pupae and from pupae to adult mosquitoes remained unaffected. Therefore, dioncophylline A can be regarded as a promising specific larvicide.
authors.affiliation: Laboratorium voor Protozoölogie, Prins Leopold Instituut voor Tropische Geneeskunde, Antwerpen, Belgium.
authors.forename: G
authors.initials: G
authors.lastname: François
authors.forename: M
authors.initials: M
authors.lastname: Van Looveren
authors.forename: G
authors.initials: G
authors.lastname: Timperman
authors.forename: B
authors.initials: B
authors.lastname: Chimanuka
authors.forename: L
authors.initials: L
authors.lastname: Aké Assi
authors.forename: J
authors.initials: J
authors.lastname: Holenz
authors.forename: G
authors.initials: G
authors.lastname: Bringmann
mesh_terms: D000470:Alkaloids; D000818:Animals; D000852:Anopheles / Q000254:growth & development; D007303:Insect Vectors; D007306:Insecticides; D007546:Isoquinolines; D007814:Larva; D008288:Malaria / Q000635:transmission; D010936:Plant Extracts; D011679:Pupa
chemical_list: D000470:Alkaloids; D007306:Insecticides; D007546:Isoquinolines; D010936:Plant Extracts; C104320:dioncophylline A