title: A potentially misleading presentation and course of acute myelomonocytic leukemia in a dog.
abstract: A nine-year-old, castrated male golden retriever had lethargy, fever, massive peripheral lymphadenomegaly, hepatosplenomegaly, and pale mucous membranes. There was a marked leukocytosis (456.3 x 10(3) cells/microliter) with 99% blasts; a moderate, nonregenerative anemia; and marked thrombocytopenia. A tentative diagnosis of acute lymphocytic leukemia was made pending results of cytochemical staining. Despite the severity of the laboratory and clinical findings, the dog exhibited a partial response to an induction chemotherapy protocol commonly used for lymphoma. Subsequent cytochemical staining of the original blood and bone-marrow samples resulted in a revised diagnosis of acute myelomonocytic leukemia (AML-M4). Clinicopathological findings, response to treatment, and clinical outcome in this case of canine AML-M4 are discussed.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824, USA.
authors.forename: T K
authors.initials: TK
authors.lastname: Graves
authors.forename: C L
authors.initials: CL
authors.lastname: Swenson
authors.forename: M A
authors.initials: MA
authors.lastname: Scott
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001772:Blood Cell Count / Q000662:veterinary; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000097:blood / Q000473:pathology*; D004285:Dogs; D007008:Hypokalemia / Q000662:veterinary; D015479:Leukemia, Myelomonocytic, Acute / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology / Q000662:veterinary; D012709:Serum Albumin / Q000032:analysis
chemical_list: D012709:Serum Albumin; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase