Effect of chronic treatment with atenolol and prazosin in streptozotocin induced diabetic rats.
Diabetes-mellitus was induced in rats by single intravenous injection of (45 mg/kg) streptozotocin (STZ). STZ diabetic rats showed hypertension, decreased cardiac functions, cardiomyopathy and hypercholesterolemia observed at the end of six weeks. Chronic treatment with atenolol (10 mg/kg) for six weeks in the diabetic rats reduced the elevated blood pressure, but failed to prevent STZ induced other complications. Chronic treatment with prazosin (1 mg/kg, po) in the diabetic rats, reduced the elevated blood pressure and also partially prevented hypercholesterolemia, cardiac dysfunctions and in particular the cardiomyopathy. The results suggest that prazosin may be a better option as compared to atenolol in hypertension when it is associated with diabetes mellitus.
Goyal
R K
RK
Department of Pharmacology, L.M. College of Pharmacy, Ahmedabad.
Bangaru
R A
RA
Lakkad
N B
NB
Rao
M V
MV
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001262:Atenolol / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D008055:Lipids / Q000097:blood; D011224:Prazosin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D008055:Lipids; D001262:Atenolol; D013311:Streptozocin; D011224:Prazosin