Unexpected high density of neuropeptide Y Y1 receptors in the guinea pig spleen.
Receptors for neuropeptide Y (NPY) and peptide YY (PYY) have been extensively characterized in the brain. Less is known about NPY receptor subtypes in the spleen, though it is well established that NPY produces vascular contraction in this tissue. In the present study, we found an unusually high density of Y1 receptors in the guinea pig spleen. These receptors are localized to the red pulp and exhibit a pharmacology that is consistent with the Y1 receptor. On the other hand, only very low densities for Y2 receptors were observed. Therefore, the guinea pig spleen may be a ideal tissue for further study of the role of Y1 receptors in cardiovascular and immune function.
Gehlert
D R
DR
CNS Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.
Gackenheimer
S L
SL
D000818:Animals; D001345:Autoradiography; D002540:Cerebral Cortex / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D009478:Neuropeptide Y / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism; D019894:Peptide YY; D010455:Peptides / Q000378:metabolism; D017476:Receptors, Neuropeptide Y / Q000145:classification / Q000378:metabolism*; D013154:Spleen / Q000378:metabolism*
D009478:Neuropeptide Y; D010446:Peptide Fragments; D010455:Peptides; D017476:Receptors, Neuropeptide Y; C097212:neuropeptide Y-Y1 receptor; C095889:neuropeptide Y2 receptor; D019894:Peptide YY