title: Contralateral lung injury associated with single-lung ischemia-reperfusion injury.
abstract: BACKGROUND
  There have been very few studies on the effect of single-lung ischemia-reperfusion on the function of the contralateral lung. This study was designed to clarify the effect.
  
  
  METHODS
  Fifteen mongrel dogs were divided into two groups. In group 1 (n = 7), the left lung was subjected to ischemia without ventilation for 90 minutes, and then reperfused. In group II (n = 8), the lung was not subjected to ischemia, and was ventilated during the 90-minute ischemia of group I. Arterial blood gas, hemodynamics, extravascular lung water, and airway pressure were measured. Pulmonary biopsy was performed to evaluate adenine nucleotide levels. The protein concentration and phosphorous concentration of phospholipids in bronchoalveolar lavage fluid were measured.
  
  
  RESULTS
  Group I, with perfusion and ventilation of the right lung alone, was significantly inferior to group II with respect to arterial blood gas, right pulmonary compliance, extravascular lung water of the right lung, and the protein concentration in the bronchoalveolar lavage fluid of the right lung after the 90-minute period.
  
  
  CONCLUSIONS
  These results indicate that 90 minutes of warm ischemia and reperfusion of the left lung caused deterioration of not only the left but also contralateral right pulmonary function.
authors.affiliation: Second Department of Surgery, Sapporo Medical University and Hospital, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Watanabe
authors.forename: N
authors.initials: N
authors.lastname: Kawaharada
authors.forename: K
authors.initials: K
authors.lastname: Kusajima
authors.forename: S
authors.initials: S
authors.lastname: Komatsu
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
mesh_terms: D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid; D004285:Dogs; D015633:Extravascular Lung Water / Q000378:metabolism; D006439:Hemodynamics; D008168:Lung / Q000098:blood supply* / Q000378:metabolism; D008170:Lung Compliance; D016040:Lung Transplantation; D010100:Oxygen / Q000097:blood; D015427:Reperfusion Injury / Q000378:metabolism / Q000503:physiopathology*; D014655:Vascular Resistance
chemical_list: D000227:Adenine Nucleotides; D010100:Oxygen