title: Cerebral haemorrhage complicating adult-onset Still's disease: a case report.
abstract: The case of a 75-year-old Japanese woman with adult-onset Still's disease who presented with cerebral haemorrhage is described. She had been in clinical remission for 2 years, after induction therapy including non-steroidal anti-inflammatory drugs, prednisolone, cyclophosphamide and mizoribine followed by auranofin, until her cerebral haemorrhage occurred, although her serum level of ferritin had gradually increased. After the onset of cerebral haemorrhage, the patient's serum level of thrombomodulin was elevated although c-reactive protein and lactate dehydrogenase were not increased. Anti-cardiolipin antibody and lupus anti-coagulant were not detected. Patients with adult-onset Still's disease are rarely reported to develop cerebral vascular disease, possibly because the disease is most frequent in young adults. The cerebral haemorrhage may have been caused by the vasculitis due to Still's disease.
authors.affiliation: Department of Medicine, Kusatsu Branch Hospital, Gunma University Hospital, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kurabayashi
authors.forename: K
authors.initials: K
authors.lastname: Kubota
authors.forename: K
authors.initials: K
authors.lastname: Tamura
authors.forename: T
authors.initials: T
authors.lastname: Shirakura
mesh_terms: D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use; D002543:Cerebral Hemorrhage / Q000097:blood / Q000150:complications* / Q000209:etiology; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D016706:Still's Disease, Adult-Onset / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D018180:Thrombomodulin / Q000097:blood; D014657:Vasculitis / Q000150:complications
chemical_list: D018501:Antirheumatic Agents; D018180:Thrombomodulin; D005293:Ferritins