title: Risk of asthma in children with a history of croup.
abstract: All fourth-grade school children in Munich and the surrounding districts (age 9-11 years, n = 9403) were surveyed with a questionnaire, lung function testing and bronchial provocation. Croup was reported in 9.8%. In these children, lung function was decreased even after controlling for asthma and other confounding factors. Only recurrent croup had an increased prevalence in children with asthma. When a family history for asthma, maternal smoking and social status were included into a logistic multiple regression model, the odds ratio to develop asthma was 2.91 (confidence interval (CI) 2.19 - 3.86) for children with a history of croup, 2.60 (CI 1.93 - 3.51) for a family history for asthma and 8.60 (CI 4.99 - 14.80) for the combination of family history and croup. Asthma was diagnosed in 37.3% of children with croup and a positive family history.
authors.affiliation: Universitätskinderklinik München, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Nicolai
authors.forename: E V
authors.initials: EV
authors.lastname: Mutius
mesh_terms: D001249:Asthma / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D002648:Child; D003430:Cross-Sectional Studies; D003440:Croup / Q000150:complications* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D012008:Recurrence; D012129:Respiratory Function Tests; D012307:Risk Factors