title: [The risk factors for the development of the multiple organ failure syndrome in destructive pancreatitis].
abstract: The role of neutrophil leukocytes in the development of the polyorgan failure syndrome during an unfavorable course of destructive pancreatitis is discussed. The examinations of 52 patients demonstrated a high correlation of neutrophil functional activity tests (nitroblue tetrazolium reduction test and leukocyte-platelet aggregation) and disorders of microcirculation and hepatorenal involvement (detected clinically and by laboratory tests). The "critical mass" of leukocytosis has been estimated: at least 18 . 10(9)/liter, at which the risk of polyorgan failure appreciably increases. The authors discuss the advisability of selective cytopheresis in a complex of intensive care for critical states involving endogenous poisoning and leukocytosis.
authors.forename: I P
authors.initials: IP
authors.lastname: Vereshchagin
authors.forename: A V
authors.initials: AV
authors.lastname: Zolotarev
authors.forename: D I
authors.initials: DI
authors.lastname: Kuznetsov
mesh_terms: D000208:Acute Disease; D000328:Adult; D005260:Female; D006801:Humans; D007964:Leukocytosis / Q000097:blood / Q000150:complications / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D010195:Pancreatitis / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors
vernacular_title: Faktory riska razvitiia sindroma poliorgannoĭ nedostatochnosti pri destruktivnom pankreatite.