Proliferative activity, angiogenesis, and necrosis in peripheral nerve sheath tumors: a quantitative evaluation for prognosis.
Malignant peripheral nerve sheath tumors (MPNSTs) are distinguished from a control group of typical benign schwannomas and neurofibromas on the basis of a set of quantitatively evaluated parameters, i.e., the cell density; the number of mitoses and apoptotic bodies; the nuclear area and shape; the number and absolute and relative areas of silver-staining nucleolar organizer regions; necrosis; and angiogenesis. Only the extent of tumor necrosis, the mitotic rate, and the parameters related to silver-staining nucleolar organizer regions discriminate between less aggressive MPNSTs (disease-free patients after 4 years of follow-up) and more aggressive MPNSTs (with recurrences or metastases during the first 4 years of follow-up).
Miracco
C
C
Institute of Pathologic Anatomy and Histology, University of Siena, Italy.
Montesco
M C
MC
Santopietro
R
R
Spina
D
D
d'Amore
E S
ES
Tosi
P
P
Ninfo
V
V
D000328:Adult; D000368:Aged; D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000378:metabolism; D002452:Cell Count; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D008938:Mitosis; D009336:Necrosis; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology*; D009442:Neurilemmoma / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D009455:Neurofibroma / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D009697:Nucleolus Organizer Region / Q000473:pathology; D010524:Peripheral Nervous System Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D011379:Prognosis; D012509:Sarcoma / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*
D014408:Biomarkers, Tumor