title: Lack of association between alpha 1-antichymotrypsin polymorphism, Alzheimer's disease, and allele epsilon 4 of apolipoprotein E.
abstract: We investigated the possibility that a polymorphism of alpha 1-antichymotrypsin modifies the risk for Alzheimer's disease (AD). Testing 147 AD patients and 74 controls, we did not find evidence of an association between alpha 1-antichymotrypsin polymorphism and AD and also failed to detect a modifying effect of this polymorphism in patients carrying at least one epsilon 4 allele of apolipoprotein E.
authors.affiliation: Institut für Humangenetik, Justus-Liebig-Universität, Giessen, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Müller
authors.forename: R H
authors.initials: RH
authors.lastname: Bödeker
authors.forename: I
authors.initials: I
authors.lastname: Gerundt
authors.forename: A
authors.initials: A
authors.lastname: Kurz
mesh_terms: D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D000514:alpha 1-Antichymotrypsin / Q000235:genetics*
chemical_list: D001057:Apolipoproteins E; D000514:alpha 1-Antichymotrypsin