title: [Thoracic pain of esophageal origin. Assessment of 125 consecutive patients with resting angina and angiographically normal coronary arteries].
abstract: BACKGROUND
  The esophagus may be the origin of chest pain clinically indistinguishable from that of myocardial ischemia. Gastroesophageal reflux (GER) and esophageal motility disorders (EMDs) are the main causes of esophageal chest pain, and esophageal motility tests are important for an appropriate diagnosis. We studied 125 unselected patients with angiographically normal coronary arteries presenting with atypical (resting) angina which was shown not to be of cardiac origin.
  
  
  METHODS
  Stationary esophageal manometry and 24-hour pH studies were performed in all patients, and 116 of them were submitted to edrophonium provocation test (Tensilon, 10 mg as IV bolus).
  
  
  RESULTS
  Spastic EMDs were identified as an isolated abnormality in 23 patients (18%), whereas GER was documented in 70 patients (56%). Esophageal dysmotility at baseline manometry (n = 40), a positive edrophonium test (n = 19), abnormal acid reflux indices by 24-hour pH recording (n = 62), and association of chest pain with acid reflux during pH testing (n = 24) variably overlapped in many patients. The esophagus was directly blamed as the source of atypical angina in 33 patients (26%) who had induction of their usual chest pain by cholinergic stimulation and/or association of spontaneous pain events with acid reflux.
  
  
  CONCLUSIONS
  Esophageal dysfunction in common in patients with atypical angina considered not to be of cardiac origin and contributes to patients' symptoms. Because they may detect treatable causes of chest pain such as GER or contribute to management by assessing the diagnosis of EMD, esophageal motility tests are indicated in many patients with noncardiac chest pain.
authors.affiliation: Servicios de Gastroenterología, Hospital Clínic i Provincial, Universidad de Barcelona.
authors.forename: E
authors.initials: E
authors.lastname: Ros
authors.forename: V
authors.initials: V
authors.lastname: Toledo-Pimentel
authors.forename: L
authors.initials: L
authors.lastname: Grande
authors.forename: G
authors.initials: G
authors.lastname: Lacima
authors.forename: X
authors.initials: X
authors.lastname: Armengol
authors.forename: G
authors.initials: G
authors.lastname: Sanz
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000209:etiology*; D002637:Chest Pain / Q000209:etiology*; D017023:Coronary Angiography; D004935:Esophageal Diseases / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D015154:Esophageal Motility Disorders / Q000150:complications / Q000175:diagnosis; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000175:diagnosis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests
vernacular_title: Dolor torácico de origen esofágico. Evaluación de 125 pacientes consecutivos con angina de reposo y arterias coronarias angiográficamente normales.