title: Enteric absorption of ciprofloxacin during tube feeding in the critically ill.
abstract: To determine the pharmacokinetic properties of ciprofloxacin in the critically ill, we studied seven mechanically ventilated patients with pneumonia during enteral feedings. Subjects received ciprofloxacin 750 mg every 12 h via nasogastric tube and serial serum drug concentrations were measured after the first and fourth dose. After the initial dose, the maximum serum concentration ranged from 1.24-3.06 mg/L, and the area under the time curve from 0-12 h ranged from 3.2-19.65 mg.h/L. Similar levels were noted after dose four. Gastrointestinal absorption of ciprofloxacin in tube fed critically ill patients was decreased, but well above MIC values for many pathogenic bacteria.
authors.affiliation: Department of Surgery, Yale School of Medicine, New Haven, CT 06520, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Cohn
authors.forename: M D
authors.initials: MD
authors.lastname: Sawyer
authors.forename: G A
authors.initials: GA
authors.lastname: Burns
authors.forename: C
authors.initials: C
authors.lastname: Tolomeo
authors.forename: K A
authors.initials: KA
authors.lastname: Milner
mesh_terms: D018806:APACHE; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D016638:Critical Illness; D004750:Enteral Nutrition; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000188:drug therapy / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin