Esters of cephalosporins. Part II. Differences in the properties of various forms of the 1-acetoxyethyl ester of cefuroxime.
Physico-chemical and microbiological properties of three different forms (crystalline and two amorphous ones) of the 1-acetoxyethyl ester of cefuroxime and bioavailability after oral administration to rats have been investigated. Relation between physico-chemical properties of these forms and their bioavailability is observed. It is shown, that for oral administration the most appropriate is an amorphous form obtained by rapid evaporation of a solvent from solution of the ester.
Oszczapowicz
I
I
Department of Modified Antibiotics, Institute of Biotechnology and Antibiotics, Warsaw, Poland.
Małafiej
E
E
Szelachowska
M
M
Horoszewicz-Małafiej
A
A
Kuklewicz
C
C
Sierańska
E
E
Denys
A
A
Niedworok
J
J
D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002444:Cefuroxime / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D002511:Cephalosporins / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D006207:Half-Life; D008297:Male; D008826:Microbial Sensitivity Tests; D011355:Prodrugs / Q000493:pharmacokinetics* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013211:Staphylococcus aureus / Q000187:drug effects
D002511:Cephalosporins; D011355:Prodrugs; D002444:Cefuroxime; C040738:cefuroxime axetil