Onset of dementia is associated with apolipoprotein E epsilon4 in Down's syndrome.
We examined the influence of apolipoprotein E (apoE) genotype on risk of dementia in 82 adults with Down's syndrome (DS). Compared with those with an apoE 3/3 genotype, the group of adults with DS with apoE 2/4, 3/4, and 4/4 genotypes were 5 times more likely to become demented (RR = 4.7; 95% CI = 1.2, 17.9). We hypothesize that the increased risk of dementia may be mediated by exacerbation of beta-amyloid deposition.
Schupf
N
N
Laboratory of Epidemiology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA.
Kapell
D
D
Lee
J H
JH
Zigman
W
W
Canto
B
B
Tycko
B
B
Mayeux
R
R
D000328:Adult; D000368:Aged; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics*; D003704:Dementia / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D004314:Down Syndrome / Q000235:genetics* / Q000523:psychology*; D005260:Female; D005838:Genotype; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012307:Risk Factors
D053327:Apolipoprotein E4; D001057:Apolipoproteins E