Pulsed electromagnetic fields in experimental cutaneous wound healing in rats.
Electromagnetic fields are now being used in many diseases such as osseous, ligamental, cartilaginous, or nervous reparation, diabetes, and myocardial or cerebral ischemia. Although many publications show the usefulness of magneto-therapy, discrepancies exist about the utility of electromagnetic fields in skin wound healing. The objective of this work was to study the effect of pulsed electromagnetic fields on wound healing in rats. Twenty-two male Wistar rats were used; a circular lesion was made in the back of each animal. They were divided into three groups: group C (control) with sham treatment (n = 8), group NF, treated with topical nitrofurazone solution (n = 7), and group PEMF, treated with pulsed electromagnetic fields of 20 mT (n = 7). The treatments were 35 minutes twice a day. The absolute and relative values of the area and perimeter of the wounds showed significantly lower values in the PEMF group at days 7, 14, and 21 compared with those in group C (p < 0.01, analysis of variance), whereas the PEMF group showed significantly lower values at day 21 only compared with the NF group (p < 0.01, analysis of variance). The results suggest a significant beneficial stimulation in the wound healing process in rats treated with PEMF, which could lead to the development of a practical tool for research and clinical use.
Patiño
O
O
Department of Postgraduate Reconstructive and Plastic Surgery, Universidad del Salvador and Fundación del Quemado.
Grana
D
D
Bolgiani
A
A
Prezzavento
G
G
Miño
J
J
Merlo
A
A
Benaim
F
F
D000287:Administration, Topical; D000704:Analysis of Variance; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004574:Electromagnetic Fields; D008297:Male; D009583:Nitrofurazone / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000528:radiation effects*; D014947:Wounds and Injuries / Q000628:therapy*
D000891:Anti-Infective Agents, Local; D009583:Nitrofurazone