The interaction of agouti signal protein and melanocyte stimulating hormone to regulate melanin formation in mammals.
Important regulatory controls of melanogenesis that operate at the subcellular level to modulate the structural and/or the functional nature of the melanins and melanin granules produced in melanocytes are reviewed. Melanocyte stimulating hormone and agouti signal protein have antagonistic roles and possibly opposing mechanisms of action in the melanocyte. In the mouse, melanocyte stimulating hormone promotes melanogenic enzyme function and elicits increases in the amount of eumelanins produced, while agouti signal protein reduces total melanin production and elicits the synthesis of pheomelanin rather than eumelanin. We are now beginning to understand the complex controls involved in regulating this switch at the molecular and biochemical levels. The quality and quantity of melanins produced by melanocytes have important physiological consequences for melanocyte function and undoubtedly play important roles in the various functions of the melanins per se, including hair and skin coloration and photoprotection.
Furumura
M
M
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Sakai
C
C
Abdel-Malek
Z
Z
Barsh
G S
GS
Hearing
V J
VJ
D054366:Agouti Signaling Protein; D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008322:Mammals; D008543:Melanins / Q000096:biosynthesis*; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism*; D008969:Molecular Sequence Data; D010858:Pigmentation / Q000502:physiology*; D011506:Proteins / Q000378:metabolism*
D054366:Agouti Signaling Protein; D036341:Intercellular Signaling Peptides and Proteins; D008543:Melanins; D011506:Proteins; D009074:Melanocyte-Stimulating Hormones