title: [Iodobenzylguanide-131 therapy as first choice in non-metastasized neuroblastoma].
abstract: Three children with a localized pelvic neuroblastoma are presented. Because of progression and clinical signs of compression of adjacent structures therapy was necessary. Targeted radiotherapy with 131I-MIBG was used as the first mode of therapy. This new strategy proved to be feasible, effective and non-toxic. Application of 131I-MIBG as first-line therapy should be considered more often in neuroblastoma patients.
authors.affiliation: Academisch Medisch Centrum, locatie Emma Kinderziekenhuis/Hel Kinder AMC, afd. Kinderoncologie, Amsterdam.
authors.forename: J
authors.initials: J
authors.lastname: De Kraker
authors.forename: C A
authors.initials: CA
authors.lastname: Hoefnagel
authors.forename: H N
authors.initials: HN
authors.lastname: Caron
authors.forename: A
authors.initials: A
authors.lastname: Vos
authors.forename: J
authors.initials: J
authors.lastname: Bras
authors.forename: J C
authors.initials: JC
authors.lastname: Greve
mesh_terms: D019797:3-Iodobenzylguanidine; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D018305:Ganglioneuroblastoma / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D007462:Iodobenzenes / Q000627:therapeutic use*; D008297:Male; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D010386:Pelvic Neoplasms / Q000473:pathology / Q000532:radiotherapy*
chemical_list: D000970:Antineoplastic Agents; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine
vernacular_title: Jobenguaan-131-therapie als eerste keus bij het niet gemetastaseerde neuroblastoom.