[Lipoprotein (a) and serum lipid levels young subjects with parents suffering from myocardial infarct].
BACKGROUND
Elevated concentrations of lipoprotein (a) have been shown to increase the risk of coronary artery disease, especially in females, and have been found to be elevated in white US children with parental myocardial infarction.


METHODS
To confirm the generality of this finding and to determine the influence of gender, we studied 143 children with parental myocardial infarction (cases), 71 males and 72 females, mean age 17 +/- 5 years, body mass index 22.1 +/- 3.8 and 102 controls, 50 males and 52 females, mean age 18 +/- 5 years, body mass index 23 +/- 4.3.


RESULTS
The serum cholesterol and lipoprotein (a) levels were significantly higher, whereas the HDL level was significantly lower in cases than in controls; lipoprotein (a) levels > 30 md/dl were significantly more prevalent in cases than in controls. Among the males, serum HDL cholesterol was significantly lower in cases than in controls, whereas no significant differences were found in serum total cholesterol and in lipoprotein (a). Among the females, cases had lower HDL cholesterol level and higher serum total cholesterol and lipoprotein (a) levels in comparison to controls.


CONCLUSIONS
Children with parental myocardial infarction, in particular the females, have a more unfavourable serum lipid profile than controls.
Gaeta
G
G
Divisione di Cardiologia, Azienda Ospedaliera Antonio Cardarelli, Napoli.
Cuomo
S
S
Boeri
F
F
Foglia
M C
MC
Iovine
C
C
Boccalatte
A
A
D000293:Adolescent; D000328:Adult; D000375:Aging; D002648:Child; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications* / Q000235:genetics; D006951:Hyperlipoproteinemias / Q000150:complications* / Q000235:genetics; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D009203:Myocardial Infarction / Q000235:genetics*; D012307:Risk Factors; D012737:Sex Factors
D017270:Lipoprotein(a)
Livelli della lipoproteina (a) e dei lipidi sierici in giovani con familiarita per infarto del miocardio.