Mechanism of action of leflunomide: in vivo uridine administration reverses its inhibition of lymphocyte proliferation.
Silva
H T
HT
Department of Cardiothoracic Surgery, Stanford University School of Medicine, California 94305-5247, USA.
Cao
W
W
Shorthouse
R
R
Morris
R E
RE
D000818:Animals; D000090722:Dihydroorotate Dehydrogenase; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007555:Isoxazoles / Q000494:pharmacology*; D000077339:Leflunomide; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D044925:Oxidoreductases Acting on CH-CH Group Donors; D051381:Rats; D011917:Rats, Inbred Lew; D013936:Thymidine / Q000378:metabolism; D014529:Uridine / Q000494:pharmacology*
D000090722:Dihydroorotate Dehydrogenase; D007166:Immunosuppressive Agents; D007555:Isoxazoles; D010088:Oxidoreductases; D044925:Oxidoreductases Acting on CH-CH Group Donors; D000077339:Leflunomide; D013936:Thymidine; D014529:Uridine