[Pathogenesis of post-transplantation osteopathy].
Osteoporosis following allogenic organ transplantation represents an increasingly common medical and socioeconomic problem. Contributing factors include hospitalization, long-term immobilization, and usage of immunosuppressive drugs (glucocorticoids, cyclosporine A) in patients who undergo transplantation. In addition, complications of underlying diseases and adverse effects of drugs used in their management such as glucocorticoids, laxatives, loop diuretics, and heparin may promote the development of posttransplant osteoporosis. Consideration of individual risk factors involved in the pathogenesis of posttransplant osteoporosis is mandatory for appropriate prevention and treatment.
Hofbauer
L C
LC
Medizinischen Klinik, Klinikums Innenstadt der Ludwig-Maximilians-Universität München, Deutschland.
Heufelder
A E
AE
D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D016030:Kidney Transplantation; D016377:Organ Transplantation; D010024:Osteoporosis / Q000209:etiology*; D011183:Postoperative Complications / Q000209:etiology*; D012307:Risk Factors
D007166:Immunosuppressive Agents
Pathogenese der Posttransplantations-Osteopathie.