title: Maternal and fetal effects of adrenaline with bupivacaine (0.25%) for epidural analgesia during labour.
abstract: The use of adrenaline added to bupivacaine during epidural analgesia for labour is controversial. The effects of epidural analgesia with bupivacaine containing adrenaline on maternal blood pressure and heart rate, uterine activity, progress of labour, fetal heart rate and Apgar scores, were assessed using visual analogue pain scores, upper level of sensory block and motor blockade in 60 parturients who were allocated randomly to receive: 10 mL of bupivacaine 0.25% plain (group I) or with adrenaline 5 micrograms mL-1 (group II) or with adrenaline 1.66 micrograms mL-1 (group III). The first stage of labour was significantly longer in group II than in group I [414 +/- 49 vs. 296 +/- 24 min (+/- SD)]. There were no other significant differences. It is concluded that adrenaline at 5 micrograms mL-1 significantly prolongs the first stage of labour. Neither adrenaline 5 micrograms mL-1 nor 1.66 micrograms mL-1 has any beneficial effect.
authors.affiliation: Département d'Anesthésie-Réanimation, Hôpital, Antoine Béclère, Clamart, France.
authors.forename: M
authors.initials: M
authors.lastname: Dounas
authors.forename: B O
authors.initials: BO
authors.lastname: O'Kelly
authors.forename: S
authors.initials: S
authors.lastname: Jamali
authors.forename: F J
authors.initials: FJ
authors.lastname: Mercier
authors.forename: D
authors.initials: D
authors.lastname: Benhamou
mesh_terms: D015360:Analgesia, Epidural; D016362:Analgesia, Obstetrical; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000494:pharmacology; D001034:Apgar Score; D001794:Blood Pressure / Q000187:drug effects; D002045:Bupivacaine / Q000008:administration & dosage / Q000494:pharmacology*; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006340:Heart Rate, Fetal / Q000187:drug effects; D006801:Humans; D007743:Labor, Obstetric / Q000187:drug effects; D010147:Pain Measurement; D011247:Pregnancy; D014590:Uterine Contraction / Q000187:drug effects
chemical_list: D000779:Anesthetics, Local; D002045:Bupivacaine; D004837:Epinephrine