title: Molecular population genetics of the alcohol dehydrogenase locus in the Hawaiian drosophilid D. mimica.
abstract: Sequence variation among 10 alleles of the alcohol dehydrogenase (Adh) gene of the Hawaiian drosophilid D. mimica was analyzed with reference to the evolutionary history of the Hawaiian subgroup as well as to levels and patterns of polymorphism of the Adh gene in continental drosophilid species. The Adh gene of D. mimica is less polymorphic than that of other drosophilid species, and no replacement substitutions were found. Statistical analyses of the Adh alleles suggested the action of balancing selection and revealed significant linkage disequilibrium among three of the variable sites. The effective population size was estimated to be only slightly smaller than that of continental species and, surprisingly, on the same order of magnitude as the actual size.
authors.affiliation: Institute of Molecular Evolutionary Genetics, Pennsylvania State University 16802, USA. fja2@psuvm.psu.edu
authors.forename: F J
authors.initials: FJ
authors.lastname: Ayala
authors.forename: C D
authors.initials: CD
authors.lastname: Campbell
authors.forename: R K
authors.initials: RK
authors.lastname: Selander
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000818:Animals; D004330:Drosophila / Q000201:enzymology / Q000235:genetics*; D005260:Female; D017344:Genes, Insect / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D006254:Hawaii; D008969:Molecular Sequence Data; D010802:Phylogeny; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA
chemical_list: D000426:Alcohol Dehydrogenase