[A new type of ionotropic glutamate receptors].
The possibility of the existence of a new type of ionotropic glutamate receptor differing from NMDA and non-NMDA receptors was confirmed by cloning cDNA for XenNR1, a channel-forming subunit of the glutamate receptor from the Xenopus laevis brain. Cotransfection of the HEK-293 cells with the cDNAs for XenNR1 and XenU1 (a non-NMDA receptor subunit from X. laevis brain) resulted in the biosynthesis of a functionally active heterosubunit receptor composed of NMDA and non-NMDA subunits. The functional co-expression of the XenNR1 and XenU1 cDNAs is the first direct evidence for the existence of a new type of glutamate receptor.
Solov'ev
M M
MM
Department of Molecular Neurobiology, Medical School, Royal Free Hospital, London, Great Britain.
Barnard
E A
EA
Grishin
E V
EV
D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D003001:Cloning, Molecular; D018076:DNA, Complementary; D006801:Humans; D008969:Molecular Sequence Data; D017470:Receptors, Glutamate / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D029867:Xenopus Proteins / Q000235:genetics*; D014982:Xenopus laevis
D018076:DNA, Complementary; D017470:Receptors, Glutamate; D029867:Xenopus Proteins; C512833:nodal1 protein, Xenopus
Novyĭ tip ionotropnykh glutamatnykh retseptorov.