title: [Physico-chemical characteristics of meglumine antimoniate in different storage conditions].
abstract: During the period October 1992 to July 1995 we measured the osmolarity and pH of ampoules of meglumine antimoniate (glucantime) from lot 9206L-004 (manufactured by Rhodia Farma Ltd, of São Paulo, SP, Brazil) maintained in three temperature conditions namely 4 degrees C, 37 degrees C and ambiental. Although we observed statistically significant differences in osmolarity between samples, the limited number of measurements and the variation of this property in ampoules maintained at the same temperature were obstacles to obtain definitive conclusions. Such a variation was not found with pH. Assuming these parameters could reflect structural changes in the pentavalent antimony molecule, clearly further better controlled experiments are indicated.
authors.affiliation: Universidade de Brasilia, DF. gromero@guarany.cpd.unb.br
authors.forename: G A
authors.initials: GA
authors.lastname: Romero
authors.forename: M R
authors.initials: MR
authors.lastname: de Oliveira
authors.forename: D
authors.initials: D
authors.lastname: Correia
authors.forename: P D
authors.initials: PD
authors.lastname: Marsden
mesh_terms: D000981:Antiprotozoal Agents / Q000737:chemistry*; D004356:Drug Storage; D006863:Hydrogen-Ion Concentration; D008536:Meglumine / Q000737:chemistry*; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000737:chemistry*; D009994:Osmolar Concentration
chemical_list: D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate
vernacular_title: Características físico-químicas do antimoniato de meglumina em diferentes condições de armazenamento.