title: The sequence of 5' flanking DNA from the mouse 11 beta-hydroxysteroid dehydrogenase type 1 gene and analysis of putative transcription factor binding sites.
abstract: 11 beta-Hydroxysteroid dehydrogenase type 1 (E.C. 1.1.1.146) (11 beta-HSD 1) is a key enzyme in the metabolism of glucocorticoids, catalysing their interconversion with physiologically inert 11-keto metabolites. To identify transcription factors which may be involved in the regulation of expression of mouse 11 beta-HSD 1 we have isolated and sequenced the 5' flanking DNA to 900 bp upstream from the major transcription start site.
authors.affiliation: Molecular Medicine Centre, Western General Hospital, Edinburgh, UK.
authors.forename: M W
authors.initials: MW
authors.lastname: Voice
authors.forename: J R
authors.initials: JR
authors.lastname: Seckl
authors.forename: K E
authors.initials: KE
authors.lastname: Chapman
mesh_terms: D042842:11-beta-Hydroxysteroid Dehydrogenases; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000378:metabolism*; D015971:Gene Expression Regulation, Enzymologic; D006913:Hydroxysteroid Dehydrogenases / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D051381:Rats; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors; D004247:DNA; D006913:Hydroxysteroid Dehydrogenases; D042842:11-beta-Hydroxysteroid Dehydrogenases