Sublingual buprenorphine compared to morphine delivered by a patient-controlled analgesia system as postoperative analgesia after prostatectomy.
After open prostatectomy, 52 patients were randomly allocated to two treatment groups. Group A (26 patients) received buprenorphine sublingually, and in group B (26 patients) the analgesia was induced using a patient-controlled analgesia system with morphine. The total dose of morphine given during the first 24 h was 72 +/- 8 mg compared to 1.6 +/- 0.45 mg of buprenorphine. The total dose of buprenorphine on days 2 and 3 was significantly lower than the total dose of morphine (p < 0.01). There were no significant differences in visual pain scores, side effects, mean arterial blood pressure, pulse rate and respiration rate between the two groups. Sublingual application of buprenorphine offers an effective and easy alternative to the parenteral route of morphine for the management of postoperative pain.
Gaitini
L
L
Department of Anaesthesiology, Bnai Zion Medical Center, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Moskovitz
B
B
Katz
E
E
Vaisberg
A
A
Vaida
S
S
Nativ
O
O
D000286:Administration, Sublingual; D000368:Aged; D000369:Aged, 80 and over; D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects; D001794:Blood Pressure / Q000187:drug effects; D002047:Buprenorphine / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D011468:Prostatectomy; D011674:Pulse / Q000187:drug effects; D012119:Respiration / Q000187:drug effects
D000701:Analgesics, Opioid; D002047:Buprenorphine; D009020:Morphine