Photo-induced toxic epidermal necrolysis caused by clobazam.
Toxic epidermal necrolysis (TEN) is a life-threatening disease, the pathogenesis of which remains largely unknown. We describe a 23-year-old woman under treatment with clobazam who developed lesions of TEN in light-exposed areas. Patch and photopatch tests with clobazam were negative. The cellular phenotype and cytokines were studied in blister fluid. The cellular infiltrate was composed mainly of T lymphocytes with a predominant cytotoxic phenotype. There was an increase in the level of tumour necrosis factor (TNF)-alpha in blister fluid compared with the control (a patient with bullous pemphigoid).
Redondo
P
P
Department of Dermatology, University Clinic of Navarra, School of Medicine, Pamplona, Spain.
Vicente
J
J
España
A
A
Subira
M L
ML
De Felipe
I
I
Quintanilla
E
E
D000328:Adult; D000506:Alopecia Areata / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D014151:Anti-Anxiety Agents / Q000009:adverse effects*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000009:adverse effects*; D000078306:Clobazam; D005122:Exudates and Transudates / Q000276:immunology; D005260:Female; D006801:Humans; D010787:Photosensitivity Disorders / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D014409:Tumor Necrosis Factor-alpha; D001569:Benzodiazepines; D000078306:Clobazam