Interlaboratory reproducibility in reporting inadequate cervical smears--a multicentre multinational study.
A set of 300 vaginal smears was interpreted by 13 cytologists from six European laboratories, who were requested to report inadequate and suboptimal smears. The set had been appropriately seeded to reach approximately 10% inadequate and 20% suboptimal smear frequency. According to the majority report, 230 smears were classified as adequate (76.7%), 43 as inadequate (14.3%), and 27 as suboptimal (9.0%). Agreement with the majority report ranged from 52% to 91% (average 78%). Kappa statistics for reporting inadequate smears showed a high level of agreement for five cytologists, and fair to good agreement for eight. In contrast, kappa statistics for reporting suboptimal smears showed fair to good agreement with the majority report only in five instances, whereas agreement was poor for eight cytologists. 'Inadequate smear' rates may be used to compare the quality of smears received in different laboratories, as there is a high level of agreement among cytologists as to what constitutes an inadequate smear. However, this is not true for "suboptimal smear" rates, and more precise reporting criteria must be defined and tested if an intermediate category is to be retained to report poor quality smears: more precise reporting criteria must be defined and tested if an intermediate category is to be retained to report poor quality smears.
Ciatto
S
S
Centro per lo Studio e la Prevenzione Oncologica, Firenze, Italy.
Cariaggi
M P
MP
Minuti
A P
AP
Confortini
M
M
Palli
D
D
Pas
L
L
McKee
G
G
Schenck
U
U
Bonaccorsi
A
A
Corradi
G
G
Olivati
S
S
Pieri
L
L
Carretti
D
D
Cocchi
V
V
D005060:Europe; D005260:Female; D006801:Humans; D007391:International Cooperation; D008403:Mass Screening / Q000592:standards*; D011786:Quality Control; D015203:Reproducibility of Results; D002583:Uterine Cervical Neoplasms / Q000517:prevention & control*; D014626:Vaginal Smears / Q000379:methods / Q000592:standards*