title: [Structure of immunological defect in laryngeal papillomatosis in children].
abstract: 81 children aged from 10 months to 15 years with laryngeal papillomatosis (LP) were studied immunologically. Two groups of the patients were formed: by age and frequency of LP recurrences. Multifactorial estimation covered T and B immunity, factors of nonspecific defense. It was found that LP patients had T-cell immunodeficiency indicated by a reduction in the number of CD2--DR+, CD2, CD3, CD4 lymphocytes and suppression of nonspecific defense as shown by decreased C3--component of complement, number of NK-cells, lymphocyte enzyme activity. LP correlated clinically with immunogenetic abnormalities which proved most severe in older children with more frequent recurrences and least severe in the same age group with rare recurrences. The authors infer on interdependence of immunodeficiency and human papillomatosis virus infection. It is thought valid to enter immunomodulation in LP treatment.
authors.forename: E A
authors.initials: EA
authors.lastname: Tsvetkov
authors.forename: I V
authors.initials: IV
authors.lastname: Savenko
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000293:Adolescent; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003176:Complement C3 / Q000032:analysis; D006801:Humans; D007153:Immunologic Deficiency Syndromes; D007223:Infant; D007822:Laryngeal Neoplasms / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D018655:Lymphocyte Count; D010212:Papilloma / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications; D013601:T-Lymphocytes / Q000276:immunology; D014412:Tumor Virus Infections / Q000150:complications
chemical_list: D000276:Adjuvants, Immunologic; D003176:Complement C3
vernacular_title: Struktura immunologicheskogo defekta pri papillomatoze gortani u deteĭ.