title: Effect of sevoflurane anaesthesia on plasma concentrations of glutathione S-transferase.
abstract: To assess the effect of sevoflurane anaesthesia on hepatocellular integrity, we measured plasma concentrations of glutathione S-transferase (GST) before anaesthesia and 1, 3, 6 and 24 h after the end of anaesthesia in 41 healthy, Japanese patients undergoing elective, body surface surgery. Sevoflurane (approximately 1.0 MAC) was delivered in 50-66% nitrous oxide in oxygen via a circle system, with a fresh gas flow of 6 litre min-1. Ventilation was spontaneous in all patients. Mean duration of anaesthesia was 101 min. Concentrations of GST increased significantly 1 h after the end of anaesthesia (P = 0.0075), but this was not significantly different from preoperative concentrations at 3, 6 and 24 h. Three patients developed a large secondary increase in GST concentrations at 24 h. The increase observed at 1 h was probably a result of reduced total liver blood flow; the mechanism for the secondary increase at 24 h is unclear but the possibility that products of sevoflurane biotransformation are responsible cannot be excluded.
authors.affiliation: Department of Anaesthetics, Royal Infirmary, Edinburgh.
authors.forename: D C
authors.initials: DC
authors.lastname: Ray
authors.forename: R
authors.initials: R
authors.lastname: Bomont
authors.forename: A
authors.initials: A
authors.lastname: Mizushima
authors.forename: T
authors.initials: T
authors.lastname: Kugimiya
authors.forename: A
authors.initials: A
authors.lastname: Forbes Howie
authors.forename: G J
authors.initials: GJ
authors.lastname: Beckett
mesh_terms: D000328:Adult; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D004987:Ethers / Q000494:pharmacology*; D005982:Glutathione Transferase / Q000097:blood*; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008738:Methyl Ethers; D008875:Middle Aged; D011184:Postoperative Period; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D015415:Biomarkers; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D005982:Glutathione Transferase