title: Effect of oxytocin on growth hormone release in vitro.
abstract: The effect of oxytocin (OT) on growth hormone (GH) secretion was investigated using dispersed rat anterior pituitary cells. OT dose-dependently inhibited GH secretion as well as GHRH-stimulated GH release. The inhibitory actions of OT on GH release were totally abolished by pretreatment with the OT-antagonist VAP 259. The peptides galanin and cholecystokinin did not affect the OT-induced inhibition on basal or GHRH-stimulated GH release. Several possible mechanisms by which OT may influence GH release are discussed.
authors.affiliation: Department of Endocrinology, Karolinska Hospital, Stockholm, Sweden.
authors.forename: A L
authors.initials: AL
authors.lastname: Hulting
authors.forename: E
authors.initials: E
authors.lastname: Grenbäck
authors.forename: J
authors.initials: J
authors.lastname: Pineda
authors.forename: R
authors.initials: R
authors.lastname: Coya
authors.forename: T
authors.initials: T
authors.lastname: Hökfelt
authors.forename: B
authors.initials: B
authors.lastname: Meister
authors.forename: K
authors.initials: K
authors.lastname: Uvnäs-Moberg
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D019004:Galanin / Q000494:pharmacology; D013006:Growth Hormone / Q000378:metabolism*; D006727:Hormone Antagonists / Q000494:pharmacology; D008297:Male; D010121:Oxytocin / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012844:Sincalide / Q000494:pharmacology; D013268:Stimulation, Chemical
chemical_list: D006727:Hormone Antagonists; C104764:VAP 259; D010121:Oxytocin; D019004:Galanin; D013006:Growth Hormone; D012844:Sincalide