title: Poly(ethylene glycol) fluorescent linkers.
abstract: The first examples of PEG linkers containing the highly fluorescent dansyl group have been synthesized. Quantum yields of these PEG fluorescent linkers (PFL) were determined and utilized in calculating the PEG number of various protein conjugates. The method was also shown to be applicable to lower molecular weight drugs as exemplified by taxol.
authors.affiliation: Enzon, Inc., Piscataway, New Jersey 08854, USA.
authors.forename: A
authors.initials: A
authors.lastname: Pendri
authors.forename: A
authors.initials: A
authors.lastname: Martinez
authors.forename: J
authors.initials: J
authors.lastname: Xia
authors.forename: R G
authors.initials: RG
authors.lastname: Shorr
authors.forename: R B
authors.initials: RB
authors.lastname: Greenwald
mesh_terms: D000818:Animals; D002417:Cattle; D003619:Dansyl Compounds / Q000138:chemical synthesis / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D017239:Paclitaxel / Q000737:chemistry; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry; D011506:Proteins / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry
chemical_list: D003619:Dansyl Compounds; D005456:Fluorescent Dyes; D011506:Proteins; D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols; D017239:Paclitaxel