title: [Tetrofosmin: a new compound labeled with 99mTc for the study of myocardial perfusion. Correlations with coronary anatomy in patients with suspected ischemic cardiopathy].
abstract: The aim of this study was to investigate the accuracy of quantitative one-day exercise-rest 99mTc tetrofosmin tomography in the identification of patients with suspected coronary artery disease (CAD) and in the detection of single stenosed coronary vessels. Sixty-one patients with suspected CAD and submitted to coronary angiography were examined. All patients were given 2 i.v. injections of 99mTc tetrofosmin, one at peak exercise (370 MBq) and the other (1110 MBq) at rest 3 hours after exercise (images 15-30 min after injection for both studies). All patients with CAD (> or = 50% luminal stenosis) (n = 50) had abnormal 99mTc tetrofosmin tomogram (100% sensitivity). Only one patient without CAD had abnormal 99mTc tetrofosmin tomogram (91% specificity). Overall sensitivity, specificity, and diagnostic accuracy in the detection of single stenosed vessels were 77%, 93% and 85%, respectively. No significant differences among single vascular areas were observed. Sensitivity and diagnostic accuracy in the identification of single stenosed coronary vessels were significantly higher (p < 0.05) in the patients with single-vessel disease (n = 21) than in those with multivessel disease (n = 29). Sensitivity, specificity and diagnostic accuracy in detecting single diseased vessels were similar in the patients without (n = 26) and in those with previous myocardial infarction (n = 35). The results of this study demonstrate that quantitative one-day exercise-rest 99mTc tetrofosmin SPECT imaging is a suitable and accurate technique to identify patients with suspected CAD and to detect single stenosed coronary vessels.
authors.affiliation: Istituto di Scienze Radiologiche, Università Federico II, Napoli.
authors.forename: S
authors.initials: S
authors.lastname: Cardei
authors.forename: A
authors.initials: A
authors.lastname: Cuocolo
authors.forename: P
authors.initials: P
authors.lastname: Sullo
authors.forename: A
authors.initials: A
authors.lastname: Nappi
authors.forename: E
authors.initials: E
authors.lastname: Nicolai
authors.forename: M R
authors.initials: MR
authors.lastname: Grivet Fojaja
authors.forename: A
authors.initials: A
authors.lastname: Discepolo
authors.forename: F
authors.initials: F
authors.lastname: Menna
authors.forename: L
authors.initials: L
authors.lastname: Pace
authors.forename: L
authors.initials: L
authors.lastname: Argenziano
authors.forename: M
authors.initials: M
authors.lastname: Salvatore
mesh_terms: D000328:Adult; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging*; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C078700:technetium tc-99m tetrofosmin
vernacular_title: La tetrofosmina: un nuovo composto marcato con 99mTc per lo studio della perfusione miocardica. Correlazioni con l'anatomia coronarica nei pazienti con sospetta cardiopatia ischemica.