title: [Geographic differences in the frequency of chromosome alterations characteristic of cancer of the large intestine].
abstract: The authors' material (33 tumours) and that from foreign literature (18 to 100 tumours from every country) was used. The following chromosome aberrations were compared: the deletion of a part of chromosome 1 short arm, deletion of chromosome 5 and a part of its long arm, additional chromosomes 7, complete or partial deletion of chromosome 17 short arm, deletion of chromosome 18 and appearance of additional chromosomes 20. Clear-cut differences were revealed between the following three groups of regions: 1) countries of the Eastern and Western Europe (Russia, France, Germany); 2) Northern Europe countries (Denmark, SWeden); 3) USA and China. Geographical differences in chromosome anomalies in hemoblastosis were found in 1970s, the difference in colon carcinoma are presented for the first time. The experimental results suggest that non-homogeneous distribution of the karyotype alterations typical for certain morphological types of malignant tumours are due to different environmental influences.
authors.forename: E V
authors.initials: EV
authors.lastname: Fleĭshman
authors.forename: L N
authors.initials: LN
authors.lastname: Konstantinova
authors.forename: O E
authors.initials: OE
authors.lastname: Kulagina
authors.forename: V I
authors.initials: VI
authors.lastname: Knysh
authors.forename: V V
authors.initials: VV
authors.lastname: Delektorskaia
authors.forename: D A
authors.initials: DA
authors.lastname: Turbin
authors.forename: A G
authors.initials: AG
authors.lastname: Perevoshchikov
mesh_terms: D002681:China / Q000453:epidemiology; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D005602:France / Q000453:epidemiology; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007621:Karyotyping; D012537:Scandinavian and Nordic Countries / Q000453:epidemiology; D014481:United States / Q000453:epidemiology
vernacular_title: Geograficheskie razlichiia v chastote khromosomnykh izmeneniĭ kharakternykh dlia raka tolstoĭ kishki.