Plasma cells composing plasmacytoma have phenotypes different from those of myeloma cells.
We describe one relapsed case of plasmacytoma of mandibular bone. The organs of relapse were liver and bone marrow. At relapse, monoclonal gammopathy (IgG-kappa) was observed without suppression of IgA and IgM. By immunostaining, the plasma cells of both the original mandibular bone and liver were positive for the same cytoplasmic immunoglobulin light chain kappa. The proliferative plasma cells in the bone marrow had the phenotype of CD38+, CD19+, and CD56- by flow cytometry and showed the presence of the rearranged IgH gene by Southern blotting. In addition, the zone of the Ig class of the patient's serum was not so sharply defined by zone electrophoresis. These results suggest that the characteristics of plasma cells of plasmacytoma are different from those of multiple myeloma.
Sakai
A
A
Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan.
Fujii
T
T
Noda
M
M
Hyodo
H
H
Oda
K
K
Kimura
A
A
D036541:ADP-ribosyl Cyclase; D051997:ADP-ribosyl Cyclase 1; D000368:Aged; D015703:Antigens, CD / Q000032:analysis*; D018941:Antigens, CD19 / Q000032:analysis; D000943:Antigens, Differentiation / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis*; D001853:Bone Marrow / Q000473:pathology; D019002:CD56 Antigen / Q000032:analysis; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D005803:Genes, Immunoglobulin; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics / Q000276:immunology; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D016130:Immunophenotyping; D008113:Liver Neoplasms / Q000276:immunology / Q000473:pathology / Q000556:secondary; D008297:Male; D008339:Mandibular Neoplasms / Q000276:immunology / Q000473:pathology*; D008562:Membrane Glycoproteins; D009101:Multiple Myeloma / Q000276:immunology / Q000473:pathology*; D009699:N-Glycosyl Hydrolases / Q000032:analysis; D009363:Neoplasm Proteins / Q000032:analysis*; D014411:Neoplastic Stem Cells / Q000737:chemistry*; D010950:Plasma Cells / Q000737:chemistry*; D010954:Plasmacytoma / Q000276:immunology / Q000473:pathology* / Q000556:secondary
D015703:Antigens, CD; D018941:Antigens, CD19; D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D019002:CD56 Antigen; D007143:Immunoglobulin Heavy Chains; D007145:Immunoglobulin kappa-Chains; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D009699:N-Glycosyl Hydrolases; D036541:ADP-ribosyl Cyclase; C498154:CD38 protein, human; D051997:ADP-ribosyl Cyclase 1