title: Angiotensinogen in human essential hypertension.
abstract: The candidacy of angiotensinogen for a role in the genetic basis of hypertension is supported by the observation that plasma angiotensinogen levels track with raised blood pressure through families. In addition, transgenic mice with overexpression of a rat angiotensinogen gene develop hypertension, and knockout mice with a disrupted gene and absent angiotensinogen production develop low blood pressure. There are now two studies in populations of white European origin and one in African Caribbeans providing support for a role of the angiotensinogen gene locus in human essential hypertension.
authors.affiliation: Department of Clinical Pharmacology, St Bartholomew's Hospital, London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Caulfield
authors.forename: P
authors.initials: P
authors.lastname: Lavender
authors.forename: J
authors.initials: J
authors.lastname: Newell-Price
authors.forename: S
authors.initials: S
authors.lastname: Kamdar
authors.forename: M
authors.initials: M
authors.lastname: Farrall
authors.forename: A J
authors.initials: AJ
authors.lastname: Clark
mesh_terms: D000808:Angiotensinogen / Q000235:genetics*; D000818:Animals; D008040:Genetic Linkage; D014644:Genetic Variation; D006801:Humans; D006973:Hypertension / Q000235:genetics*
chemical_list: D000808:Angiotensinogen