title: Preliminary experience with low-dose methotrexate in fibroblastic rheumatism.
abstract: Fibroblastic rheumatism (FR) is a rare disease characterized by joint manifestations without joint destruction, and associated with cutaneous nodules and sclerodactyly. The diagnosis is usually based on histologic examination of a skin nodule or synovium specimen. In the 11 previously reported cases, corticosteroid treatment, which has been widely used, was shown to have an unpredictable effect on the evolution of FR. We report a case of FR that was treated with methotrexate for 5 years, which led to complete recovery. This drug may be considered an effective treatment for FR. Further cases are needed to confirm this preliminary experience.
authors.affiliation: Hôpital de Boisguillaume, CHU de Rouen, France.
authors.forename: O
authors.initials: O
authors.lastname: Vittecoq
authors.forename: O
authors.initials: O
authors.lastname: Mejjad
authors.forename: F
authors.initials: F
authors.lastname: da Silva
authors.forename: P
authors.initials: P
authors.lastname: Joly
authors.forename: E
authors.initials: E
authors.lastname: Thomine
authors.forename: P
authors.initials: P
authors.lastname: Lauret
authors.forename: J M
authors.initials: JM
authors.lastname: Thomine
authors.forename: X
authors.initials: X
authors.lastname: le Loët
mesh_terms: D001706:Biopsy; D004305:Dose-Response Relationship, Drug; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage* / Q000627:therapeutic use*; D008875:Middle Aged; D012216:Rheumatic Diseases / Q000188:drug therapy* / Q000473:pathology*; D012867:Skin / Q000473:pathology
chemical_list: D008727:Methotrexate