Intracoronary magnesium and diltiazem affect to a similar extent certain hemostatic factors during acute myocardial infarction in swine.
The use of calcium antagonists and magnesium (Mg) in the treatment of acute myocardial infarction is controversial. We compared changes in hemostasis during acute myocardial infarction after either low-dose intracoronary Mg or diltiazem infusion in 20 Yorkshire swine undergoing thoracotomy and coronary artery occlusion for 50 min, followed by 3 h of reperfusion. The first group received MgSO4 (250 mg), delivered at the onset of reperfusion, the second group received diltiazem (2.5 mg) at the beginning of reperfusion. Six controls received saline. Plasma antithrombin III, protein C, total protein S, fibronectin, endothelin 1, and metabolites of thromboxane and prostacyclin were measured at baseline, twice during occlusion, and three times during reperfusion. Compared to controls, Mg and diltiazem infusion diminished endothelin 1 (32.9 vs. 34.5%) and fibronectin. (21.7 vs. 23.2%), but increased protein C (31.9 vs. 29.3%). Intracoronary Mg, like diltiazem, improved hemostasis in swine.
Serebruany
V L
VL
Heart Associates Research and Education Foundation, Union Memorial Hospital, Baltimore, MD 21218, USA.
Schlossberg
M L
ML
Edenbaum
L R
LR
Herzog
W R
WR
Gurbel
P A
PA
D000818:Animals; D000990:Antithrombin III / Q000378:metabolism; D001779:Blood Coagulation Factors / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004110:Diltiazem / Q000494:pharmacology*; D015777:Eicosanoids / Q000378:metabolism; D019332:Endothelin-1 / Q000378:metabolism; D005260:Female; D005353:Fibronectins / Q000378:metabolism; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D008274:Magnesium / Q000494:pharmacology*; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology*; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy / Q000503:physiopathology; D011486:Protein C / Q000378:metabolism; D017293:Protein S / Q000378:metabolism; D013552:Swine
D001779:Blood Coagulation Factors; D002121:Calcium Channel Blockers; D015777:Eicosanoids; D019332:Endothelin-1; D005353:Fibronectins; D011486:Protein C; D017293:Protein S; D000990:Antithrombin III; D004110:Diltiazem; D008274:Magnesium