Synthesis and properties of some aryloxyaminoalkanes.
New aryloxyaminoalkanes Ia-f and VI were prepared by O-alkylation of either the appropriate phenols using (R,S)-N-(1-bromo-2-butyl)-phthalimide or in reaction of (R,S)-N-(2-hydroxy-1-butyl)-phthalimide [II] with the use of 4-chloronitrobenzene. The structure of the synthesized compounds was verified by elemental analysis, IR, 1H NMR and mass spectral data. Compounds Ia, Id and Ie were subjected to preliminary pharmacological studies on the circulatory system activity.
Marona
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H
Department of Chemical Technology of Drugs, Collegium Medicum, Jagiellonian University, Kraków, Poland.
Gajewczyk
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L
Filipek
B
B
D000478:Alkylation; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D015195:Drug Design; D004562:Electrocardiography / Q000187:drug effects; D004837:Epinephrine / Q000633:toxicity; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009578:Nitrobenzenes / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012015:Reference Standards; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
D000889:Anti-Arrhythmia Agents; D009578:Nitrobenzenes; C010407:4-chloronitrobenzene; D004837:Epinephrine