Destroying retroviruses from within.
One strategy for neutralizing retroviral infectivity is to induce the incorporation of lethal fusion proteins, such as capsid protein-nuclease fusions, into the virion during the normal viral assembly process. Genes encoding such antiviral fusion proteins must be nontoxic to the host, lethal to the virus, and must be efficiently delivered to, and expressed in, appropriate target cells.
Boeke
J D
JD
Dept of Molecular Biology & Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. jef.boeke@qmail.bs.jhu.edu
Hahn
B
B
D000998:Antiviral Agents / Q000627:therapeutic use*; D015316:Genetic Therapy / Q000379:methods*; D006678:HIV / Q000235:genetics; D008954:Models, Biological; D008979:Moloney murine leukemia virus / Q000235:genetics; D011993:Recombinant Fusion Proteins / Q000627:therapeutic use*; D018626:Retroelements; D012192:Retroviridae Infections / Q000517:prevention & control*
D000998:Antiviral Agents; D011993:Recombinant Fusion Proteins; D018626:Retroelements