title: [Prospective study of subjective stress caused by dobutamine stress echocardiography--effect on diagnostic accuracy].
abstract: We used a standardized questionnaire to assess physical and mental distress caused by dobutamine stress echocardiography (DSE). The examination was performed according to a standardized protocol (5-40 micrograms/kg/min including atropine). 91 patients (pts), 68 men (62 +/- 9 years), 23 women (65 +/- 7 years) were asked to quantify the severity of the following symptoms: palpitations, anxiety, headache, nausea, discomfort of left lateral position, angina pectoris and dyspnea. Numbers on a rating scale from 1-10 defined the degree of distress. Absence of a symptom equalled mark, 1, slight expression marks 2-4. Moderate expression was defined by marks 5-7 and very strong expression by marks 8-10.
  
  
  RESULTS
  86% of pts felt affected by one or more symptoms to a slight to moderate extent (mark 4 +/- 2.17). Palpitations were felt by 85% of the pts (mark 6 +/- 2.83), anxiety by 42% (mark 3 +/- 2.5), headache by 50% (3 +/- 2.54), nausea by 20% (2 +/- 1.72), angina pectoris by 42% (3 +/- 2.5), dyspnea by 30% (2 +/- 2.42) and discomfort of left lateral recumbent position by 43% (mark 3 +/- 2.59). 43 pts underwent coronary angiography. The negative predictive value of DSE to identify pts without a coronary artery stenosis extending a 50% diameter reduction was 85% for the 16 pts who reached their individual submaximal heart rate compared to 60% for those 27 pts who did not reach it. Unspecific symptoms led to test termination in these pts. The positive predictive values were comparable (89 and 94%).
  
  
  CONCLUSIONS
  DSE causes physical and mental distress. If symptoms lead to test termination before age corrected submaximal heart rate is reached, normal wall motion does not exclude significant coronary artery disease.
authors.affiliation: II. Medizinische Klinik Johannes-Gutenberg-Universität Mainz.
authors.forename: S
authors.initials: S
authors.lastname: Wagner
authors.forename: S
authors.initials: S
authors.lastname: Mohr-Kahaly
authors.forename: U
authors.initials: U
authors.lastname: Nixdorff
authors.forename: B
authors.initials: B
authors.lastname: Kölsch
authors.forename: T
authors.initials: T
authors.lastname: Menzel
authors.forename: N
authors.initials: N
authors.lastname: Wittlich
authors.forename: R
authors.initials: R
authors.lastname: Meinert
authors.forename: J
authors.initials: J
authors.lastname: Meyer
mesh_terms: D000787:Angina Pectoris / Q000000981:diagnostic imaging / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary; D002316:Cardiotonic Agents / Q000009:adverse effects; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000628:therapy; D004280:Dobutamine / Q000009:adverse effects; D004452:Echocardiography / Q000187:drug effects; D005080:Exercise Test / Q000187:drug effects; D005260:Female; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000628:therapy; D010342:Patient Acceptance of Health Care; D011237:Predictive Value of Tests
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine
vernacular_title: Prospektive Untersuchung zur subjektiven Beeinträchtigung durch die Dobutaminbelastungsechokardiographie--Auswirkung auf die diagnostische Sicherheit.