title: Evaluation of technetium-99m-ECD in childhood epilepsy.
abstract: In childhood epilepsy, it is difficult, but of critical importance, to determine whether surgical intervention might be beneficial for an individual patient. Because both established procedures-MRI and electroencephalography (EEG)-have limitations, interictal and ictal regional cerebral blood flow (rCBF) SPECT has proven to be a valuable adjunctive method in the presurgical evaluation of children.
  
  
  METHODS
  We evaluated the usefulness of the new rCBF tracer 99mTc-ECD in 14 children with focal epilepsy (mean age 9.7 yr). Eleven interictal and 8 ictal studies were performed. Results were correlated with ictal and interictal surface EEG, MRI and histological findings and the postsurgical outcome.
  
  
  RESULTS
  On the basis of the presurgical evaluation, nine patients underwent surgery. MRI studies demonstrated pathological features with possible relation to epilepsy in 50%. Overall, interictal 99mTc-ECD SPECT showed areas of hypoperfusion in 80% of patients. Ictal rCBF SPECT was informative in all patients, including one who showed bifrontal hyperperfusion in accordance with EEG results.
  
  
  CONCLUSIONS
  Technetium-99m-ECD has proven to be of value for interictal and ictal rCBF SPECT in childhood epilepsy. No side effects during or after tracer administration were noticed. Ictal and interictal rCBF SPECT showed good correlation with MRI and EEG results in patients in whom correlation with the postoperative situation was possible and presented additional significant information in those patients with normal MRI and uninterpretable EEG results. No false lateralizations occurred. In children with focal epilepsy, interictal rCBF SPECT may accelerate the application of long-term electrocorticography (ECoG) in patients with normal MRI results. Ictal rCBF SPECT may also help to avoid ECoG, if a focal hyperperfusion correlates with a focal MRI abnormality, and the surface EEG gives no contradictory information.
authors.affiliation: Department of Nuclear Medicine, University of Bonn, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Menzel
authors.forename: S
authors.initials: S
authors.lastname: Steidele
authors.forename: F
authors.initials: F
authors.lastname: Grünwald
authors.forename: A
authors.initials: A
authors.lastname: Hufnagel
authors.forename: L
authors.initials: L
authors.lastname: Pavics
authors.forename: C E
authors.initials: CE
authors.lastname: Elger
authors.forename: H J
authors.initials: HJ
authors.lastname: Biersack
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D002560:Cerebrovascular Circulation / Q000502:physiology; D002648:Child; D003545:Cysteine / Q000031:analogs & derivatives*; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D015609:Organotechnetium Compounds; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; C059659:technetium Tc 99m bicisate; D003545:Cysteine