title: Late complications of immune deviation therapy in a nonhuman primate.
abstract: The administration of antigens in soluble form can induce antigen-specific immune tolerance and suppress experimental autoimmune diseases. In a marmoset model of multiple sclerosis induced by myelin oligodendrocyte glycoprotein (MOG), marmosets tolerized to MOG were protected against acute disease, but after tolerization treatment a lethal demyelinating disorder emerged. In these animals, MOG-specific T cell proliferative responses were transiently suppressed, cytokine production was shifted from a T helper type 1 (TH1) to a TH2 pattern, and titers of autoantibodies to MOG were enhanced. Thus, immune deviation can increase concentrations of pathogenic autoantibodies and in some circumstances exacerbate autoimmune disease.
authors.affiliation: Department of Neurology, University of California, San Francisco, CA 94143, USA.
authors.forename: C P
authors.initials: CP
authors.lastname: Genain
authors.forename: K
authors.initials: K
authors.lastname: Abel
authors.forename: N
authors.initials: N
authors.lastname: Belmar
authors.forename: F
authors.initials: F
authors.lastname: Villinger
authors.forename: D P
authors.initials: DP
authors.lastname: Rosenberg
authors.forename: C
authors.initials: C
authors.lastname: Linington
authors.forename: C S
authors.initials: CS
authors.lastname: Raine
authors.forename: S L
authors.initials: SL
authors.lastname: Hauser
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000276:immunology*; D001323:Autoantibodies / Q000096:biosynthesis; D001921:Brain / Q000473:pathology; D002144:Callithrix; D016207:Cytokines / Q000235:genetics; D003711:Demyelinating Diseases; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D015870:Gene Expression; D007108:Immune Tolerance; D007167:Immunotherapy / Q000009:adverse effects*; D008213:Lymphocyte Activation; D009103:Multiple Sclerosis / Q000276:immunology / Q000628:therapy; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein / Q000276:immunology*; D063308:Myelin-Oligodendrocyte Glycoprotein; D011994:Recombinant Proteins / Q000276:immunology; D012995:Solubility; D013116:Spinal Cord / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
chemical_list: D000954:Antigens, Surface; D001323:Autoantibodies; D016207:Cytokines; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D011994:Recombinant Proteins