Activity of a crude extract formulation in experimental hepatic amoebiasis and in immunomodulation studies.
The activity of a crude extract formulation was evaluated in experimental amoebic liver abscess in golden hamsters and in immunomodulation studies. The formulation comprises the following five plants-Boerhavia diffusa, Tinospora cordifolia, Berberis aristata, Terminalia chebula and Zingiber officinale. The formulation had a maximum cure rate of 73% at a dose of 800 mg/kg/day in hepatic amoebiasis reducing the average degree of infection (ADI) to 1.3 as compared to 4.2 for sham-treated controls. In immunomodulation studies humoral immunity was enhanced as evidenced by the haemagglutination titre. The T-cell counts remained unaffected in the animals treated with the formulation but cell-mediated immune response was stimulated as observed in the leukocyte migration inhibition (LMI) tests.
Sohni
Y R
YR
Department of Biology, Alabama A&M University, Normal 35762, USA.
Bhatt
R M
RM
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001402:B-Lymphocytes / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D006224:Cricetinae; D006386:Hemagglutination Tests; D007107:Immune System / Q000187:drug effects*; D007111:Immunity, Cellular / Q000187:drug effects; D007958:Leukocyte Count / Q000187:drug effects; D008101:Liver Abscess, Amebic / Q000188:drug therapy* / Q000276:immunology; D008647:Mesocricetus; D008795:Metronidazole / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013601:T-Lymphocytes / Q000187:drug effects
D000276:Adjuvants, Immunologic; D010936:Plant Extracts; D011838:Radiation-Sensitizing Agents; D008795:Metronidazole