title: Hydrated sodium calcium aluminosilicate (HSCAS), acidic HSCAS, and activated charcoal reduce urinary excretion of aflatoxin M1 in turkey poults. Lack of effect by activated charcoal on aflatoxicosis.
abstract: In one experiment, the effect of inorganic sorbents on the metabolic fate of aflatoxin B1 (AFB1) was studied in turkey poults. At 5 weeks of age, female poults were surgically colostomized and 9 days later orally dosed with 0.75 mg AFB1/kg BW. Hydrated sodium calcium aluminosilicate (HSCAS), acidic HSCAS, and activated charcoal (AC) were tested, by concomitant administration with AFB1. Urine was collected up to 48 h post-dosing and analyzed for aflatoxin M1 (AFM1) which was the major metabolite found in all treatment groups. Hydrated sodium calcium aluminosilicate, previously proven beneficial in alleviating aflatoxicosis in farm animals, reduced urinary AFM1 output when orally dosed simultaneous with AFB1. Also, acidic HSCAS and AC significantly decreased AFM1 excretion when administered concomitantly with AFB1. A second experiment was conducted to evaluate the ability of two types of AC to modify aflatoxicosis when added to aflatoxin (AF)-contaminated (from culture material) diets of turkey poults. Although AC was able to decrease AFM1 excretion in the first experiment, no protective effects from AF toxicity were observed in the feeding study.
authors.affiliation: U.S. Department of Agriculture, Agricultural Research Service, College Station, TX 77845, USA.
authors.forename: T S
authors.initials: TS
authors.lastname: Edrington
authors.forename: A B
authors.initials: AB
authors.lastname: Sarr
authors.forename: L F
authors.initials: LF
authors.lastname: Kubena
authors.forename: R B
authors.initials: RB
authors.lastname: Harvey
authors.forename: T D
authors.initials: TD
authors.lastname: Phillips
mesh_terms: D016607:Aflatoxin M1 / Q000378:metabolism* / Q000652:urine; D000538:Aluminum Silicates / Q000494:pharmacology*; D000821:Animal Feed / Q000382:microbiology; D000818:Animals; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000187:drug effects; D002606:Charcoal / Q000494:pharmacology*; D005260:Female; D015651:Mycotoxicosis / Q000188:drug therapy* / Q000517:prevention & control; D009929:Organ Size / Q000187:drug effects; D014422:Turkeys
chemical_list: D000538:Aluminum Silicates; C087965:sodium calcium aluminosilicate, hydrated; D002606:Charcoal; D016607:Aflatoxin M1