Proliferation of cancer cells and stromal cells in colorectal adenocarcinomas as assessed with anti-PCNA/cyclin monoclonal antibody.
Monoclonal anti-proliferating cell nuclear antigen antibody (PCNA, PC 10) was used to measure proliferation of tumor cells and stromal cells in 27 colorectal adenocarcinomas. Mean proliferation index of cancer cells was 33.7% (SD +/- 16.3) and that of stromal cells 14.3 (SD +/- 12.5). Positive correlation between proliferation index of cancer cells and proliferation rate of stromal cells was found (r = 0.64, p < 0.001). Correlation between proliferation of stromal lymphocyte-like cells and fibroblast-like cells was noticed (r = 0.69, p < 0.001).
Markiewski
M
M
Department of Pathology, Faculty of Medicine, Pomeranian Medical Academy, Szczecin.
Zbisławski
W
W
Marlicz
W
W
Domagała
W
W
D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000032:analysis; D002455:Cell Division; D015179:Colorectal Neoplasms / Q000737:chemistry / Q000473:pathology*; D016213:Cyclins / Q000276:immunology*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008875:Middle Aged; D018809:Proliferating Cell Nuclear Antigen / Q000276:immunology*; D012189:Retrospective Studies
D000911:Antibodies, Monoclonal; D016213:Cyclins; D018809:Proliferating Cell Nuclear Antigen