[Prospects for designing immunoglobulins to prevent and treat purulent-inflammatory diseases].
The paper gives the results of prophylactic and therapeutic evaluations made in gram-negative opportunistic bacteria-induced pyoinflammatory diseases during retrospective and controlled studies of blood plasma preparations and immunoglobulins that contain antibodies to lipopolysaccharides. The data available in the literature and the authors' own findings confirm the obligatory presence of antibodies to tumor necrosis factor and to other interleukins, as well as the importance of IgM antibodies to various lipopolysaccharide determinants. The paper also presents the results the results of the authors' own investigations to design and evaluate the activity of intravenous immunoglobulin that contains antibodies to IgG and IgM lipopolysaccharides, which is termed panglobulin. Prospects for designing a combined preparation containing IgM and IgG antibodies with antiendotoxic activity and antibodies to tumor necrosis factor and other interleukins.
Levina
L A
LA
Migunov
V N
VN
Temper
R M
RM
D015195:Drug Design; D006090:Gram-Negative Bacteria / Q000737:chemistry / Q000276:immunology; D006801:Humans; D007116:Immunization, Passive / Q000379:methods*; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous / Q000276:immunology*; D007249:Inflammation; D008070:Lipopolysaccharides / Q000276:immunology; D009894:Opportunistic Infections / Q000382:microbiology / Q000628:therapy*; D013492:Suppuration
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous; D008070:Lipopolysaccharides
Perspectivy sozdaniia immunoglobulinov dlia profilaktiki i lecheniia gnoĭno-vospolitel'nykh zabolevaniĭ.