title: Human cytomegalovirus infection inhibits cell cycle progression at multiple points, including the transition from G1 to S.
abstract: Human cytomegalovirus inhibits the growth of human foreskin fibroblast cells by 12 h after infection. Analysis of the cellular DNA content of infected cells by flow cytometry demonstrated that cytomegalovirus does not arrest cell cycle progression at a single point. At least two blockages occur, one of which is in the G1 phase of the cell cycle. The G1 arrest introduced by cytomegalovirus infection blocks S-phase entry after serum stimulation.
authors.affiliation: Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, New Jersey 08544-1014, USA.
authors.forename: M
authors.initials: M
authors.lastname: Lu
authors.forename: T
authors.initials: T
authors.lastname: Shenk
mesh_terms: D002453:Cell Cycle; D002455:Cell Division; D002460:Cell Line; D003587:Cytomegalovirus / Q000378:metabolism*; D016193:G1 Phase; D006801:Humans; D016196:S Phase; D015398:Signal Transduction