title: Advanced laryngeal cancer T3-T4 in Sweden: a retrospective study 1986-1990. Survival and locoregional control related to treatment.
abstract: Different treatment modalities for advanced laryngeal cancer are much discussed in the literature. One-hundred-and-sixty patients with T3-4, N0-3, M0-1 laryngeal cancer diagnosed in Sweden between 1986 and 1990 were retrospectively analysed. One hundred (65 T3: 35 T4) received radical radiotherapy with salvage surgery (RRSS) in case of residual or recurrent disease. Thirty-eight (11T3: 27 T4) patients received surgery with or without radiotherapy (S +/- RT). Twenty-two patients received no treatment. After a median follow up of 4.4 years, the estimated 5-year actuarial corrected survival and 3-year locoregional control were 59% and 44% for T3 RRSS and 47% and 54% for T3 S +/- RT. No significant difference between the different treatment modalities was found. The 5-year corrected survival rate and the locoregional control at 3 years between T4-RRSS (32%; 26%) and T4-S + RT (58%; 68%) groups were significantly different (p < 0.05 and p < 0.01). This might suggest that surgery with or without radiotherapy still has its place as a treatment modality for patients with advanced T4 laryngeal carcinoma.
authors.affiliation: Department of Otorhinolaryngology, Sahlgrensku University Hospital, Göteborg, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Finizia
authors.forename: A
authors.initials: A
authors.lastname: Geterud
authors.forename: E
authors.initials: E
authors.lastname: Holmberg
authors.forename: J
authors.initials: J
authors.lastname: Lindström
authors.forename: J
authors.initials: J
authors.lastname: Lundgren
authors.forename: R
authors.initials: R
authors.lastname: Kuylenstierna
authors.forename: R
authors.initials: R
authors.lastname: Rylander
authors.forename: A
authors.initials: A
authors.lastname: Biörklund
authors.forename: R
authors.initials: R
authors.lastname: Rydell
authors.forename: L
authors.initials: L
authors.lastname: Andréason
authors.forename: C
authors.initials: C
authors.lastname: Mercke
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D015996:Survival Rate; D013548:Sweden / Q000453:epidemiology