Multifactorial treatment of hypertensive men at high cardiovascular risk and low-density lipoprotein cholesterol affinity to human arterial proteoglycans.
The purpose of this work was to examine in an open, randomized parallel-group study whether an intervention programme directed towards hypercholesterolaemia, smoking and diabetes mellitus in treated hypertensive men was associated with less complex formation between low-density lipoprotein (LDL) and human arterial proteoglycans than was the case with usual care. The intervention consisted mainly of non-pharmacological treatment, but drug therapy could be instituted to achieve the treatment goals in the intervention group. The intervention programme was associated with a significant reduction in body mass index, and 46% of the patients were on lipid-lowering medication at the follow-up examination. The net differences were (intervention--usual care): change in serum LDL-cholesterol, -0.48 mmol L-1 (95% confidence interval -0.84 to -0.11 mmol L-1), precipitated LDL-cholesterol, -5.5 micrograms (95% CI -9.0 to -1.1 micrograms). The latter remained after adjustment for the difference in serum LDL-cholesterol between groups. Our conclusion is that the multifactorial risk factor treatment programme was associated with a reduced tendency of LDL to form complexes with human arterial proteoglycans.
Fagerberg
B
B
Department of Medicine, Sahlgrenska University Hospital, Göteberg University, Sweden.
Wiklund
O
O
Agewall
S
S
Camejo
G
G
Wikstrand
R J
RJ
D000368:Aged; D001158:Arteries / Q000737:chemistry; D015992:Body Mass Index; D008078:Cholesterol, LDL / Q000097:blood / Q000378:metabolism; D006801:Humans; D006937:Hypercholesterolemia / Q000378:metabolism; D006973:Hypertension / Q000097:blood*; D008055:Lipids / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011509:Proteoglycans / Q000097:blood* / Q000378:metabolism; D012307:Risk Factors; D016540:Smoking Cessation
D008078:Cholesterol, LDL; D008055:Lipids; D008077:Lipoproteins, LDL; D011509:Proteoglycans