Growth factors during endotoxin-induced otitis media.
The presence of growth factors in the middle ear fluid was examined during lipopolysaccharide-induced otitis media (OM) in the chinchilla. There was a progressive significant increase in the proliferative activity detected in the LPS-free MEF by five days in culture. We conclude that lps indirectly mediates hyperproliferative changes in the middle ear during OM by inducing growth factors.
Demaria
T F
TF
Department of Otolaryngology, College of Medicine, Ohio State University, Columbus 43210, USA.
Billy
J M
JM
Danahey
D G
DG
D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D002682:Chinchilla; D004432:Ear, Middle / Q000187:drug effects*; D006133:Growth Substances / Q000378:metabolism* / Q000502:physiology; D008070:Lipopolysaccharides / Q000009:adverse effects / Q000494:pharmacology*; D010033:Otitis Media / Q000139:chemically induced*
D006133:Growth Substances; D008070:Lipopolysaccharides