[Pharmaokinetics of beta-escin after administration of various Aesculus extract containing formulations].
With a specific radioimmunoassay the pharmacokinetics and relative bioavailability of escin was measured after administration of different formulations containing Aesculus-extract. Of special interest was the relative bioavailability of escin after administration of a newly developed film-coated tablet with sustained release in comparison to a reference formulation. In a cross-over steady-state study in 24 volunteers bioequivalence of test and reference preparation could be demonstrated. The 90% confidence interval of the AUC (O-tau) was 98.3 to 120.9%.
Oschmann
R
R
Dr. Willmar Schwabe Arzneimittel, Karlsruhe, Germany.
Biber
A
A
Lang
F
F
Stumpf
H
H
Kunz
K
K
D000328:Adult; D001682:Biological Availability; D018592:Cross-Over Studies; D004928:Escin / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010946:Plants, Medicinal / Q000737:chemistry*; D011863:Radioimmunoassay; D013608:Tablets, Enteric-Coated; D013810:Therapeutic Equivalency; D014020:Tissue Extracts / Q000493:pharmacokinetics
D013608:Tablets, Enteric-Coated; D014020:Tissue Extracts; D004928:Escin
Pharmakokinetik von beta-Aescin nach Gabe verschiedener Aesculus-Extrakt enthaltender Formulierungen.