Ulinastatin ameliorates acute ischemic renal injury in rats.
Effects of ulinastatin (a Kunitz-type proteinase inhibitor) administration was examined in a model of acute ischemic renal injury induced by bilateral renal artery occlusion in rats. Compared with rats administered vehicle, rats administered ulinastatin (150,000 U/kg body weight) intravenously 30 min preischemia had significantly lower serum creatinine and blood urea nitrogen, and much less injury evident by examination of kidney histologies over the course of 48 h postreperfusion. We conclude that ulinastatin exerts a protective effect against ischemic renal injury.
Nakahama
H
H
Fifth Department of Internal Medicine, Hyogo College of Medicine, Japan.
Obata
K
K
Sugita
M
M
D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood / Q000378:metabolism*; D004195:Disease Models, Animal; D010450:Endopeptidases / Q000187:drug effects / Q000378:metabolism; D006023:Glycoproteins / Q000008:administration & dosage / Q000627:therapeutic use*; D007275:Injections, Intravenous; D007511:Ischemia / Q000188:drug therapy*; D007668:Kidney / Q000098:blood supply* / Q000293:injuries; D007677:Kidney Function Tests; D007683:Kidney Tubular Necrosis, Acute / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D014361:Trypsin Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*
D006023:Glycoproteins; D014361:Trypsin Inhibitors; D003404:Creatinine; D010450:Endopeptidases; C028665:urinastatin