Effects of an AMPA receptor modulator on methamphetamine-induced hyperactivity in rats.
The present study tested if a positive modulator of AMPA-type glutamate receptors would counteract the behavioral effects of a drug that enhances the release of dopamine. BDP-29, a compound shown to increase AMPA receptor-mediated synaptic responses in hippocampal slices, markedly attenuated the amount of stereotypic rearings seen in rats after methamphetamine injections. These results suggest that AMPA receptor modulators ameliorate certain aberrant, dopamine-related behaviors and hence may be of interest with regard to schizophrenia.
Larson
J
J
Center for the Neurobiology of Learning and Memory, University of California, Irvine 92697, USA.
Quach
C N
CN
LeDuc
B Q
BQ
Nguyen
A
A
Rogers
G A
GA
Lynch
G
G
D000818:Animals; D015259:Dopamine Agents / Q000494:pharmacology*; D006207:Half-Life; D006624:Hippocampus / Q000187:drug effects*; D006948:Hyperkinesis / Q000139:chemically induced / Q000188:drug therapy*; D066298:In Vitro Techniques; D008297:Male; D008694:Methamphetamine / Q000037:antagonists & inhibitors*; D010880:Piperidines / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
C104916:BDP 29; D015259:Dopamine Agents; D010880:Piperidines; D018091:Receptors, AMPA; D008694:Methamphetamine