Specific immunotherapy in pollinosis: I. Valuation of certain cytoimmunological indicators over the course of four years of immunotherapy in pollinosis.
The aim of this study was to identify, based on a wide range of cytoimmunological and immunological tests in combination with clinical valuations, the changes which occurred in pollinosis over the course of specific immunotherapy after the first, second, third and fourth years of treatment. Further tests were also conducted in order to demonstrate which of the indicators tested for correlated to a clinical improvement and might thus be helpful in determining the effectiveness of treatments for pollinosis. A group of 167 individuals, including subjects who had just completed their first, second, third and fourth year of desensitization treatments were tested. Levels of IgA, IgM, IgG, IgD, total and specific IgE, T-RFC, B-EAC, T-FcM-EN and T-FcG-BG lymphocyte counts, and concentrations of basal, total and specifically released blood histamine were all determined and noted. It was ascertained that the indicators best correlating to a clinical improvement over 4 years of desensitization in pollinosis were specific and total IgE, as well as the percentage of specifically released histamine present in the blood, with the level of basal histamine in the blood being constant during the entire course of the treatment. The remaining indicators which were tested did not undergo any characteristic changes over the course of 4 years of immunotherapy.
Zieliński
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Department of Histology and Embryology, Medical University of Lódź, Poland.
D000328:Adult; D003888:Desensitization, Immunologic; D005260:Female; D006636:Histamine Release / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000097:blood*; D018655:Lymphocyte Count; D008297:Male; D011058:Pollen / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis* / Q000628:therapy*
D007136:Immunoglobulins