The tuberin (TSC2), autosomal dominant polycystic kidney disease (PKD1), and somatostatin type V receptor (SSTR5) genes form a synteny group in the Fugu genome.
The tuberous sclerosis 2 (TSC2) and polycystic kidney disease 1 (PKD1) genes are adjacent on human chromosome 16p13.3 and form part of a conserved synteny group with mouse chromosome 17. We have determined that the PKD1 gene is evolutionarily conserved, single copy, and linked to TSC2 in the Fugu genome. A short cosmid contig has been identified containing both genes based on hybridization, exon trapping, and random sequence data. In addition sequences homologous to the somatostatin type V receptor (SSTR5) were identified 5' to PKD1, defining a larger syntenic region, as this gene has also been mapped to human chromosome 16p13.3. As in mammalian genomes, the Fugu TSC2 and PKD1 genes are adjacent in a tail-to-tail orientation.
Sandford
R
R
Department of Medicine, Addenbrookes Hospital, Cambridge, England, United Kingdom. rsandfor@med.cam.ac.uk
Sgotto
B
B
Burn
T
T
Brenner
S
S
D000818:Animals; D005400:Fishes, Poisonous / Q000235:genetics*; D005799:Genes, Dominant; D016678:Genome; D006801:Humans; D051379:Mice; D011506:Proteins / Q000235:genetics*; D017481:Receptors, Somatostatin / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D050396:TRPP Cation Channels; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins
D011506:Proteins; D017481:Receptors, Somatostatin; D012097:Repressor Proteins; D050396:TRPP Cation Channels; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins; C000624653:TSC2 protein, human; C000624654:Tsc2 protein, mouse; C094573:somatostatin receptor 5