title: [The perioperative use of recombinant erythropoietin (rhEPO) in Jehovah's witnesses].
abstract: Erythropoietin, the hematopoietic growth factor, is synthesised in the kidneys and liver and regulates red blood cell production. Within the last few years, recombinant DNA technology has produced synthetic erythropoietin (rhEPO). Some patients, especially Jehovah's Witnesses, will not accept blood transfusion. The perioperative administration of rhEPO increases the patients' hematocrit (HCt) to a higher than physiological level.
  
  
  RESULTS
  We report a case of a 66-year-old female Jehovah's Witness who refused blood transfusions and responded favourably to rhEPO treatment. A total hip arthroplasty was planned. A pretreatment hemoglobin level (Hb) of 13.7 g/dl and HCt of 43% were documented. After preoperative subcutaneous application of 5000 I.E. rhEPO three times per week and daily oral substitution of 300 mg ferrous sulfate over a period of 3 weeks, the Hb increased to 15.5 g/dl and the HCt to 49%. The operation was carried out after the ninth application of rhEPO. Postoperatively, the Hb concentration was 11.8 g/dl and the HCt 35%. Therefore, postoperative administration of rhEPO was not considered indicated. No side effects of rhEPO application were noted. The patient left hospital on the 10th postoperative day.
  
  
  CONCLUSIONS
  The case report describes perioperative management using human rhEPO in Jehovah's Witnesses. Treatment with rhEPO increases preoperative Hb levels to a point making it possible to compensate for operative blood loss. RhEPO combined with daily iron substitution may be useful in patients who refuse transfusion based on religious convictions.
authors.affiliation: Klinik für Anästhesie und operative Intensivmedizin, Martin-Luther-Universität Halle-Wittenberg.
authors.forename: J
authors.initials: J
authors.lastname: Soukup
authors.forename: M
authors.initials: M
authors.lastname: Menzel
authors.forename: S
authors.initials: S
authors.lastname: Roth
authors.forename: J
authors.initials: J
authors.lastname: Radke
mesh_terms: D000368:Aged; D016063:Blood Loss, Surgical / Q000503:physiopathology*; D002835:Christianity; D004921:Erythropoietin / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D005260:Female; D006400:Hematocrit; D006452:Hemoglobinometry; D006622:Hip Prosthesis; D006801:Humans; D007432:Intraoperative Period; D011994:Recombinant Proteins; D017701:Reticulocyte Count
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin
vernacular_title: Perioperativer Einsatz von rhEPO bei Angehörigen der Glaubensgemeinschaft "Zeugen Jehovas".