[Drug therapy of condylomata acuminata].
This study seeks to evaluate two candidate regimens (5-fluorouracil and interferon) as adjuvants to optimally performed laser surgery in the treatment of condylomata acuminata. Skillful laser ablation can remove any volume of human papillomavirus-associated vulvar disease but cannot prevent reactivation of the surrounding latent viral reservoir during postoperative healing. Conversely, interferon and 5-fluorouracil are relatively ineffective as primary therapies. This study involves 118 evaluable patients: 32 in the laser-CO2 group, 34 in the 5-fluorouracil group and 52 in the interferon group. At assessment of final outcome, it was found that 43 of 52 (82%) assessable patients in the adjuvant interferon arm were controlled by a single laser ablation as compared with only 17 of 34 (50%) in the 5-fluorouracil group and 13 of 32 (40%) in the laser alone group. There was no statistical difference in outcome within the 5-fluorouracil and laser only arms. Conversely, a relatively low dose of recombinant interferon, used in combination with effective surgical deleulking, can markedly reduce the risk of postoperative recurrence.
Zarcone
R
R
II Cattedra di Ginecologia ed Ostetricia, Facoltà di Medicina e Chirurgia, II Università degli Studi-Napoli.
Carfora
E
E
Bellini
P
P
Vicinanza
G
G
D000328:Adult; D003218:Condylomata Acuminata / Q000188:drug therapy* / Q000601:surgery / Q000821:virology; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D007372:Interferons / Q000627:therapeutic use*; D053685:Laser Therapy; D027383:Papillomaviridae / Q000302:isolation & purification
D007372:Interferons; D005472:Fluorouracil
Trattamento farmacologico dei condilomi acuminati.