[N-butylaspartic acid--a partial agonist of NMDA receptors?].
The convulsive and anticonvulsive properties of the N-alkyl-substituted DL-aspartic acids derivatives were studied after intracerebroventricular injections in mice. It was found that N-butyl-DL-aspartic acid shows some properties of the partial agonist of NMDA receptors.
Kamri
M
M
Piotrovskiĭ
L B
LB
Aleksandrova
I Ia
IIa
Sapronov
N S
NS
D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology*; D001224:Aspartic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D003292:Convulsants / Q000008:administration & dosage / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D007276:Injections, Intraventricular; D051379:Mice; D016202:N-Methylaspartate / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D011930:Reaction Time / Q000187:drug effects; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists* / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy
D000927:Anticonvulsants; D003292:Convulsants; D016194:Receptors, N-Methyl-D-Aspartate; D001224:Aspartic Acid; D016202:N-Methylaspartate
N-butilasparaginovaia kislota--chastichnyĭ agonist NMDA retseptorov?