Telomere associations in desmoplastic infantile ganglioglioma.
A four and a half year old male was diagnosed with desmoplastic infantile ganglioglioma. To our knowledge, the cytogenetics of this tumor have never been reported. In our analysis of 40 cells, no consistent clonal abnormalities were observed; however, the majority of cells (25 of 40) showed structural rearrangements (telomere associations) resulting in dicentrics and other derivative chromosomes. Breakpoints most often observed included 17q25 (6 of 40), 19p13.3 (4 of 40), 17p13 (3 of 40), 14q32 (3 of 40), 11q25 (3 of 40), 9p24 (2 of 40), 5q35 (2 of 40), and 22q13 (2 of 40).
Park
J P
JP
Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA.
Dossu
J R
JR
Rhodes
C H
CH
D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D002540:Cerebral Cortex; D002675:Child, Preschool; D019457:Chromosome Breakage / Q000235:genetics*; D018303:Ganglioglioma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D016615:Telomere / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*