Genetic variation of intestinal fatty acid-binding protein associated with variation in body mass in aboriginal Canadians.
We hypothesized that genomic variation affecting the primary amino acid sequence of the intestinal fatty acid-binding protein would be related to variation in body mass index and associated clinical phenotypes in aboriginal Canadians. We studied 507 adult native Canadians from an isolated community in Northern Ontario. We found that the frequency of the T54 variant of the intestinal fatty acid-binding protein gene was 0.14 in this sample. The presence of this variant was associated with significant increases in body mass index, percent body fat, and fasting plasma triglyceride concentration (P = 0.012, 0.019, and 0.012, respectively). However, the variant was not associated with the presence of diabetes mellitus. These findings suggest that the T54 variant of the intestinal fatty acid-binding protein is associated with differences in fat metabolism in this aboriginal population.
Hegele
R A
RA
St. Michael's Hospital Health Sciences Research Center, Toronto, Ontario, Canada. robert.hegele@utoronto.ca
Harris
S B
SB
Hanley
A J
AJ
Sadikian
S
S
Connelly
P W
PW
Zinman
B
B
D000328:Adult; D000368:Aged; D000483:Alleles; D044467:American Indian or Alaska Native; D015992:Body Mass Index; D002170:Canada; D002352:Carrier Proteins / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007422:Intestines / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D018996:Myelin P2 Protein / Q000235:genetics*; D009363:Neoplasm Proteins; D009765:Obesity / Q000235:genetics*; D025521:Tumor Suppressor Proteins
D002352:Carrier Proteins; C107608:FABP7 protein, human; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D018996:Myelin P2 Protein; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins