Synthesis and pharmacological properties of 1,2,3,4-tetrahydroisoquinoline derivatives.
Selected 2-isopropyl-4,6,8-trihydroxy-1,2,3,4-tetrahydroisoquinoline derivatives were synthesized and evaluated as beta-adrenoreceptor agents. These orciprenaline derivatives were found as week, partial agonists of beta-adrenoreceptors. Some of them showed good binding properties.
Brzezińska
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Institute of Chemistry and Technology of Drugs, School of Medicine, Lódź, Poland.
D000318:Adrenergic beta-Agonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000447:Aldehydes / Q000737:chemistry; D000818:Animals; D001665:Binding Sites; D001993:Bronchodilator Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D015195:Drug Design; D005260:Female; D006168:Guinea Pigs; D007545:Isoproterenol / Q000378:metabolism; D007546:Isoquinolines / Q000737:chemistry* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008565:Membrane Proteins / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D018343:Receptors, Adrenergic, beta-2 / Q000187:drug effects* / Q000378:metabolism; D012015:Reference Standards; D013329:Structure-Activity Relationship; D044005:Tetrahydroisoquinolines; D014132:Trachea / Q000187:drug effects / Q000378:metabolism
D000318:Adrenergic beta-Agonists; D000447:Aldehydes; D001993:Bronchodilator Agents; D007546:Isoquinolines; D008565:Membrane Proteins; D018343:Receptors, Adrenergic, beta-2; D044005:Tetrahydroisoquinolines; C014843:1,2,3,4-tetrahydroisoquinoline; D007545:Isoproterenol