Clinical manifestations of hypertrophic cardiomyopathy with mutations in the cardiac beta-myosin heavy chain gene or cardiac troponin T gene.
Introduction of molecular genetics has improved our understanding of HCM substantially, but has simultaneously raised further important questions. Studies on HCM are revealing a more complex picture than might have been expected on clinical grounds. Further extensive studies are warranted to elucidate the pathogenesis and pathophysiology of HCM, and to establish therapeutic strategies to cure or prevent the development of the disease.
Koga
Y
Y
Kurume University Medical Center, Fukuoka, Japan.
Toshima
H
H
Kimura
A
A
Harada
H
H
Koyanagi
T
T
Nishi
H
H
Nakata
M
M
Imaizumi
T
T
D000328:Adult; D002312:Cardiomyopathy, Hypertrophic / Q000235:genetics* / Q000503:physiopathology*; D004452:Echocardiography; D006801:Humans; D009154:Mutation; D018995:Myosin Heavy Chains / Q000235:genetics*; D011379:Prognosis; D014336:Troponin / Q000235:genetics*; D020107:Troponin T
D014336:Troponin; D020107:Troponin T; D018995:Myosin Heavy Chains