title: Should cryosurgery be considered a therapeutic option in localized prostate cancer?
abstract: Cryosurgical ablation of the prostate currently is under investigation as a potential treatment for localized prostate cancer. Results to date indicate that the majority of patients have negative biopsies and a marked reduction in prostate-specific antigen levels following cryotherapy. This treatment, however, is associated with significant side effects, notably bladder outflow obstruction, impotence, and incontinence, and its long-term durability is still unknown.
authors.affiliation: Department of Urology, University of California San Francisco/Mt. Zion Cancer Center, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Connolly
authors.forename: K
authors.initials: K
authors.lastname: Shinohara
authors.forename: J C
authors.initials: JC
authors.lastname: Presti
authors.forename: P R
authors.initials: PR
authors.lastname: Carroll
mesh_terms: D003452:Cryosurgery / Q000379:methods; D006801:Humans; D008297:Male; D018579:Patient Selection; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000601:surgery*
chemical_list: D017430:Prostate-Specific Antigen