title: A tick homologue of the human Ki nuclear autoantigen.
abstract: A clone isolated from a tick salivary gland cDNA library encodes a homologue of the human Ki lupus autoantigen, a protein of unknown function that is related to the subunits of the PA28 proteasome activator. The Ki sequences appear to be well conserved between mammals and invertebrates, with 55% identity between the tick and human primary structures. This is the first report of a Ki homologue in invertebrates.
authors.affiliation: NERC Institute of Virology and Environmental Microbiology, Oxford, UK.
authors.forename: G C
authors.initials: GC
authors.lastname: Paesen
authors.forename: P A
authors.initials: PA
authors.lastname: Nuttall
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001324:Autoantigens / Q000235:genetics*; D001483:Base Sequence; D018076:DNA, Complementary; D006168:Guinea Pigs; D006801:Humans; D008969:Molecular Sequence Data; D009124:Muscle Proteins; D009687:Nuclear Proteins / Q000235:genetics*; D046988:Proteasome Endopeptidase Complex; D011506:Proteins / Q000235:genetics; D012469:Salivary Glands; D017386:Sequence Homology, Amino Acid; D013987:Ticks / Q000235:genetics*
chemical_list: D001324:Autoantigens; D018076:DNA, Complementary; C099558:Ki antigen; D009124:Muscle Proteins; D009687:Nuclear Proteins; C085047:PSME1 protein, human; D011506:Proteins; D046988:Proteasome Endopeptidase Complex