title: Roles of cytochrome P4502C9 and cytochrome P4502C19 in the stereoselective metabolism of phenytoin to its major metabolite.
authors.affiliation: Department of Pharmaceutics, University of Washington, Seattle 98195, USA.
authors.forename: M
authors.initials: M
authors.lastname: Bajpai
authors.forename: L K
authors.initials: LK
authors.lastname: Roskos
authors.forename: D D
authors.initials: DD
authors.lastname: Shen
authors.forename: R H
authors.initials: RH
authors.lastname: Levy
mesh_terms: D001189:Aryl Hydrocarbon Hydroxylases; D002851:Chromatography, High Pressure Liquid; D065731:Cytochrome P-450 CYP2C19; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008617:Mephenytoin / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010672:Phenytoin / Q000032:analysis / Q000378:metabolism*; D013237:Stereoisomerism; D039181:Steroid 16-alpha-Hydroxylase; D013250:Steroid Hydroxylases / Q000378:metabolism*
chemical_list: D010672:Phenytoin; C025687:4-hydroxymephenytoin; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D013250:Steroid Hydroxylases; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D039181:Steroid 16-alpha-Hydroxylase; D008617:Mephenytoin