Messenger RNA translation in prokaryotes: GTPase centers associated with translational factors.
During the decoding of messenger RNA, each step of the translational cycle requires the intervention of protein factors and the hydrolysis of one or more GTP molecule(s). Of the prokaryotic translational factors, IF2, EF-Tu, SELB, EF-G and RF3 are GTP-binding proteins. In this review we summarize the latest findings on the structures and the roles of these GTPases in the translational process.
Laalami
S
S
Institut de Biologie Moléculaire et d'Ingénierie Génétique, URA-CNRS 1172, Université de Poitiers, France.
Grentzmann
G
G
Bremaud
L
L
Cenatiempo
Y
Y
D000581:Amidohydrolases / Q000378:metabolism; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000378:metabolism; D020963:GTP Phosphohydrolase-Linked Elongation Factors / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000737:chemistry; D008969:Molecular Sequence Data; D010441:Peptide Chain Elongation, Translational; D020653:Peptide Elongation Factor G; D010444:Peptide Elongation Factor Tu / Q000378:metabolism; D010445:Peptide Elongation Factors / Q000378:metabolism; D010448:Peptide Initiation Factors / Q000378:metabolism*; D039881:Prokaryotic Initiation Factor-2; D012333:RNA, Messenger / Q000378:metabolism*; D016415:Sequence Alignment
D001426:Bacterial Proteins; D020653:Peptide Elongation Factor G; D010445:Peptide Elongation Factors; D010448:Peptide Initiation Factors; D039881:Prokaryotic Initiation Factor-2; D012333:RNA, Messenger; C101656:SleB protein, Bacillus; D000581:Amidohydrolases; D020963:GTP Phosphohydrolase-Linked Elongation Factors; D019204:GTP-Binding Proteins; D010444:Peptide Elongation Factor Tu