title: Evaluation of the hypothalamic-pituitary axis in uremic males using dynamic tests. The possible role of testicular inhibin: a preliminary report.
abstract: Two dynamic tests (Gn-RH i.v. and clomiphene citrate-CC p.o.) were used to evaluate the hypothalamic-pituitary axis in hemodialysis patients and renal transplant recipients (recipients). In the Gn-RH test the gonadotropin secretion was maximally decelerated in hemodialysis patients while it was normal in recipients. During the CC test a decrease of gonadotropin secretion, chronically and quantitatively identical for both group, was found; while on the following test days an increase was noted, which was more accelerated in male recipients. In cases with uremia a strong negative feedback dominates at the pituitary level probably owing to testicular inhibin. The estrogenic feedback in uremia was intact, while the antiestrogenic feedback at the level of hypothalamus is partly impaired, owing to altered opioid metabolism.
authors.affiliation: Second Department of Gynecology and Obstetrics, Aretaieon University Hospital, Athens, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Chryssicopoulos
authors.forename: D
authors.initials: D
authors.lastname: Koutsikos
authors.forename: A
authors.initials: A
authors.lastname: Kapetanaki
authors.forename: B
authors.initials: B
authors.lastname: Agroyannis
authors.forename: H
authors.initials: H
authors.lastname: Tzanatos
authors.forename: G
authors.initials: G
authors.lastname: Rammos
authors.forename: C
authors.initials: C
authors.lastname: Fourtounas
authors.forename: I
authors.initials: I
authors.lastname: Kopelias
authors.forename: B
authors.initials: B
authors.lastname: Bossiolis
authors.forename: M
authors.initials: M
authors.lastname: Darema
authors.forename: P A
authors.initials: PA
authors.lastname: Zourlas
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002996:Clomiphene / Q000008:administration & dosage; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism / Q000503:physiopathology*; D007265:Inhibins / Q000378:metabolism*; D007275:Injections, Intravenous; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000209:etiology; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000378:metabolism / Q000503:physiopathology*; D006435:Renal Dialysis; D012680:Sensitivity and Specificity; D014511:Uremia / Q000175:diagnosis / Q000209:etiology
chemical_list: D002996:Clomiphene; D007987:Gonadotropin-Releasing Hormone; D007265:Inhibins