title: Potential for imaging cerebral amyloid deposits using 123I-labelled serum amyloid P component and SPET.
abstract: The systemic and cerebral accumulation of 123I-labelled serum amyloid P component (123I-SAP) was studied in patients with hereditary cerebral amyloid angiopathy-Dutch type (HCHWA-D) to determine the usefulness of 123I-SAP imaging in cerebral amyloidosis. Whole-body and SPET scintigraphic imaging was performed in two patients with HCHWA-D and four controls after the intraveous injection of 123I-SAP. Venous 123I-SAP clearance was also determined. Accumulation of the tracer was observed in the cerebral cortex of both patients, whereas no accumulation was seen in the controls. Blood clearance of radioactivity was similar in the patients and controls, suggesting that the amount of uptake of 123I-SAP in the cerebral amyloid deposits is relatively small. We believe this to be the first demonstration of cerebral amyloid deposits in vivo. Our findings indicate that 123I-SAP scintigraphy has possibilities for the diagnosis of patients with cerebral amyloid diseases, in addition to its use in patients with systemic amyloid deposition.
authors.affiliation: Department of Neurology, Leiden University Hospital, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Bornebroek
authors.forename: J F
authors.initials: JF
authors.lastname: Verzijlbergen
authors.forename: J
authors.initials: J
authors.lastname: Haan
authors.forename: E J
authors.initials: EJ
authors.lastname: Van Scheyen
authors.forename: N P
authors.initials: NP
authors.lastname: Verhoeff
authors.forename: E K
authors.initials: EK
authors.lastname: Pauwels
authors.forename: R A
authors.initials: RA
authors.lastname: Roos
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging*; D016657:Cerebral Amyloid Angiopathy / Q000000981:diagnostic imaging* / Q000235:genetics; D002540:Cerebral Cortex / Q000000981:diagnostic imaging; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics; D008279:Magnetic Resonance Imaging; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D012016:Reference Values; D000683:Serum Amyloid P-Component / Q000008:administration & dosage / Q000493:pharmacokinetics; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014057:Tomography, X-Ray Computed
chemical_list: D007457:Iodine Radioisotopes; D000683:Serum Amyloid P-Component