title: Fibrin deposition in Peyronie's disease plaque.
abstract: OBJECTIVE
  Peyronie's disease is a pathological fibrosis characterized by excessive deposition of collagen in the plaque. Although the etiology of Peyronie's disease is unknown, trauma has been hypothesized as the inciting event. In an effort to obtain more insight into the pathogenesis of Peyronie's disease plaque tissue was examined for collagen, elastic fiber, and fibrin content and distribution.
  
  
  METHODS
  Plaque tissue specimens from 33 patients with Peyronie's disease, control penile tissue and nodular tissue from 8 patients with Dupuytren's contracture were analyzed histochemically for collagen staining and elastic fiber structure and distribution. Plaque tissue from 19 Peyronie's disease patients, control tissue and nodular tissue from Dupuytren's disease were also analyzed for the presence of fibrin by histochemical staining and immunoblotting.
  
  
  RESULTS
  Aberrantly stained collagen was detected in 32 of 33 plaque specimens (97%) and disrupted elastic fibers in 31 of the same specimens (94%). Fibrin deposition was detected histochemically in plaque tissue from 18 of 19 patients (95%) but it was not detectable in normal or scarred tunica from control patients. The presence of authentic fibrin accumulation in plaque tissue was confirmed by immunoblot analysis but fibrin was not detected in dermal tissue extracts from the same patient. Aberrant collagen staining and fibrin deposition were detected in nodular tissue from 7 of 8 Dupuytren's contracture patients (88%) and altered elastic fibers in 5 of the same patients (63%).
  
  
  CONCLUSIONS
  Deposition of fibrin in plaque tissue is consistent with the hypothesis that repetitive microvascular injury results in fibrin deposition in the tissue space and has served to provide insights into the pathophysiology of Peyronie's disease. We propose a model that accounts for the clinical and biological features of Peyronie's disease.
authors.affiliation: Department of Microbiology and Immunology, Eastern Virginia Medical School, Norfolk, USA.
authors.forename: K D
authors.initials: KD
authors.lastname: Somers
authors.forename: D M
authors.initials: DM
authors.lastname: Dawson
mesh_terms: D000328:Adult; D000368:Aged; D003094:Collagen / Q000378:metabolism; D004549:Elastin / Q000378:metabolism; D005337:Fibrin / Q000378:metabolism*; D005355:Fibrosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010411:Penile Induration / Q000473:pathology*
chemical_list: D005337:Fibrin; D003094:Collagen; D004549:Elastin