Nasal mucosal cells in human immunodeficiency virus type 1-seropositive patients with sinusitis.
Recently, sinusitis has been recognized as a frequent clinical problem in human immunodeficiency virus (HIV-1)-infected individuals. We hypothesized that quantitative defects in immune cells in the nasal mucosa of HIV-positive subjects might mirror those in the peripheral blood and explain a predisposition to sinus disease in this population. Nasal mucosa biopsies were obtained from three different groups of patients-HIV-1 seropositive with sinusitis, HIV-1 seronegative with sinusitis, and HIV-1 seronegative without sinusitis (normal volunteer)-and phenotyped for cluster of differentiation antigen (CD) markers. In this study, we found patients with HIV-1 and sinus disease to have significantly lower numbers of both CD3 and CD4 nasal mucosa lymphocytes than seronegative controls in the nasal mucosa (P < 0.05, P < 0.01, respectively). A correlation between nasal mucosal CD4 cells and peripheral-blood CD4 cells was noted (R = 0.67, P < or = 0.01). No deficiency in the number of nasal mucosa T or TC type mast cells was noted for the HIV-1-positive sinusitis group. Further study is warranted to define more completely the pathophysiology and microbiology of, and therapy for, this important clinical problem.
Moss
R B
RB
Allergic Disease Section, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA.
Scott
T A
TA
Goldrich
M
M
Pitale
M
M
Daniel
A
A
Lebovics
R
R
Walker
R
R
Igarashi
Y
Y
Kaliner
M A
MA
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000821:virology; D015703:Antigens, CD / Q000276:immunology; D001485:Basement Membrane / Q000378:metabolism; D002452:Cell Count; D002478:Cells, Cultured; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1 / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D009297:Nasal Mucosa; D012703:Serotyping; D012852:Sinusitis / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology / Q000378:metabolism
D015703:Antigens, CD