The endogenous subtype and naturalistic course in depression.
The naturalistic course of patients with endogenous subtype of depression is described. The subtype may predict shorter times to remission, and reduced relapse risk. In the longer term, the subtype predicts increased risk of readmission, though studies on recurrence are equivocal. Recurrence of endogenous episodes may be less dependent on life events and personality factors. The subtype does not predict a greater risk of suicide, and most studies show that it does not predict a poorer long-term global outcome. Further prospective studies including operational criteria for course and outcome are needed.
O'Leary
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Department of Psychiatry, Addenbrooke's Hospital, Cambridge, UK.
D003866:Depressive Disorder / Q000145:classification / Q000175:diagnosis* / Q000523:psychology; D005500:Follow-Up Studies; D006801:Humans; D008016:Life Change Events; D010359:Patient Readmission; D012008:Recurrence; D012307:Risk Factors; D013405:Suicide / Q000523:psychology; D016896:Treatment Outcome