title: Secondary oxalosis: a cause of delayed recovery of renal function in the setting of acute renal failure.
abstract: Oxalosis, or calcium oxalate deposition in the tissues, may develop in patients with inherited disorders of oxalate metabolism or can occur secondary to other diseases. In this study, a case of renal oxalosis probably secondary to excessive parenteral vitamin C administration in a patient with acute post-traumatic oliguric renal failure is reported. Oxalate deposits may have contributed to further worsening and delayed recovery of renal function. The elimination of the source of excess vitamin C and its presumed effect on oxalate production, together with enhanced removal of oxalate during aggressive dialysis, resulted in prompt recovery of renal function. Secondary oxalosis represents a possible cause of delayed recovery of renal function in patients with acute renal failure who are receiving vitamin C supplementation if excess dosage of that supplementation is given. Vitamin C supplementation, if utilized, should be carefully monitored in patients receiving artificial renal replacement therapy.
authors.affiliation: Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Alkhunaizi
authors.forename: L
authors.initials: L
authors.lastname: Chan
mesh_terms: D001205:Ascorbic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D001706:Biopsy; D002129:Calcium Oxalate / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D017809:Fatal Outcome; D006801:Humans; D006959:Hyperoxaluria / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D007262:Infusions, Intravenous; D007668:Kidney / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D007677:Kidney Function Tests; D007683:Kidney Tubular Necrosis, Acute / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
chemical_list: D002129:Calcium Oxalate; D001205:Ascorbic Acid