title: Primary carcinoid tumor of the kidney with special reference to its histogenesis.
abstract: A case of primary carcinoid tumor of the kidney occurring in a 66-year-old woman is reported. The tumor was 10 x 10 x 9 cm in size, solid, yellowish-white in color, and associated with massive hemorrhagic necrosis. Histologically, it was composed of trabecular and anastomosing ribbon-like nests. The tumor cells showed argyrophilicity with the Grimelius stain and cytoplasmic positivity for neuroendocrine markers, (including chromogranin A, neuron-specific enolase, synaptophysin and Leu-7), prostatic acid phosphatase, keratin and vimentin. Numerous cytoplasmic neurosecretory granules were demonstrated ultrastructurally. These histologic and immunohistochemical findings are consistent with the theory that this tumor has a common phenotype with that of carcinoid tumor arising from the hindgut or cloaca.
authors.affiliation: Second Department of Pathology, Hiroshima University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takeshima
authors.forename: K
authors.initials: K
authors.lastname: Inai
authors.forename: K
authors.initials: K
authors.lastname: Yoneda
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis; D000368:Aged; D019412:Anatomy, Cross-Sectional; D002276:Carcinoid Tumor / Q000737:chemistry / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000737:chemistry / Q000209:etiology / Q000473:pathology*; D008854:Microscopy, Electron; D009846:Oliguria / Q000209:etiology; D014057:Tomography, X-Ray Computed
chemical_list: D000135:Acid Phosphatase