title: Synthesis and pharmacological profile of bicyclo[2.2.2]octane derivatives: N-(1-aryl-4-piperazinyl-butyl) derivatives of 7-isopropyl-6-methyl- and 1-isopropyl-4-methylbicyclo[2.2.2]oct-5-ene-2,3-dicarboxyimide.
abstract: The new class of compounds characterized by anxiolytic or antidepressive properties, including a number of N-(1-aryl-4-piperazinylbutyl) derivatives of the two isomers: 7-isopropyl-6-methyl- and 1-isopropyl-4-methylbicyclo [2.2.2]oct-5-ene-2,3-dicarboxyimide was synthesized. Two compounds were selected for further pharmacological study.
authors.affiliation: Department of Medical Chemistry, School of Medicine, Warsaw, Poland.
authors.forename: T
authors.initials: T
authors.lastname: Zawadowski
authors.forename: A A
authors.initials: AA
authors.lastname: Skowron
authors.forename: S
authors.initials: S
authors.lastname: Suski
authors.forename: S
authors.initials: S
authors.lastname: Rump
authors.forename: I
authors.initials: I
authors.lastname: Jakowicz
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents