title: Bone particles disturb new bone formation on the interface of the titanium implant after reaming of the marrow cavity.
abstract: Histomorphometric studies were conducted in rats to determine whether bone particles would disturb new bone formation on the interface of titanium implants inserted after reaming of the marrow cavity. In eighty 10-week-old female Wistar rats, smooth-surfaced titanium alloy implants were inserted bilaterally into the marrow cavity after reaming in the distal femur. There were three experimental groups: in the irrigated femora, sterile saline was flushed through the medullary canal; in the particle femora, autologous bone particles were inserted into the intramedullary cavity; and in the reamed femora, the implant was inserted without procedures after reaming. The rats were sacrificed at one, two, four or eight weeks postoperatively, and Villanueva bone staining was applied for histomorphometric studies. The bone volume of new bone on the interface of the implant in the irrigated femora was greater than that in the particle or the reamed femora throughout the study period. The results suggest that clearance of bone particles by irrigation after reaming of the marrow cavity significantly facilitates new bone formation on the interface of implants by one week. The findings also suggest the potential clinical application of total canal irrigation prior to insertion of cementless femoral components as well as cemented prosthesis.
authors.affiliation: Department of Orthopaedic Surgery, Niigata University School of Medicine, Niigata City, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ishizaka
authors.forename: T
authors.initials: T
authors.lastname: Tanizawa
authors.forename: M
authors.initials: M
authors.lastname: Sofue
authors.forename: Y
authors.initials: Y
authors.lastname: Dohmae
authors.forename: N
authors.initials: N
authors.lastname: Endo
authors.forename: H E
authors.initials: HE
authors.lastname: Takahashi
mesh_terms: D015502:Absorptiometry, Photon; D000818:Animals; D001672:Biocompatible Materials; D015519:Bone Density; D001853:Bone Marrow / Q000601:surgery*; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D010012:Osteogenesis / Q000502:physiology*; D019736:Prostheses and Implants; D051381:Rats; D017208:Rats, Wistar; D013499:Surface Properties; D007507:Therapeutic Irrigation / Q000379:methods*; D014025:Titanium
chemical_list: D001672:Biocompatible Materials; D014025:Titanium