Parallel computation enables precise description of Ca2+ distribution in nerve terminals.
Parallel computation employing a domain decomposition method was used to calculate precisely without approximations the spatio-temporal distribution of Ca2+ in nerve terminals. The results showed, contrary to expectations, that for equal admitted Ca2+ currents at low (one channel open) and high (four channels open) depolarization, the average Ca2+ concentration at the release area is higher at the low depolarization. These calculations provide additional support for the Ca(2+)-voltage hypothesis for neurotransmitter release.
Aharon
S
S
Department of Neurobiology, Hebrew University, Givat Ram, Jerusalem, Israel.
Bercovier
M
M
Parnas
H
H
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D008433:Mathematics; D008564:Membrane Potentials; D008959:Models, Neurological; D009411:Nerve Endings / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism
D018377:Neurotransmitter Agents; D002118:Calcium