title: Proton magnetic resonance spectroscopy of a gray matter heterotopia.
abstract: We used proton magnetic resonance spectroscopy to examine resonances representing metabolites containing N-acetyl (NA) groups (predominantly N-acetyl aspartate), choline, and creatine within a large left-hemispheric gray matter heterotopia (GMH) in a 35-year-old man with corpus callosum agenesis. In contrast to normal brain tissue, including gray matter regions, heterotopic gray matter was characterized by relatively increased choline and creatine resonances and a normal NA signal. These data suggest increased cellular activity or persistent immature neuronal tissue in GMH relative to unaffected tissue.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305-5546, USA.
authors.forename: L
authors.initials: L
authors.lastname: Marsh
authors.forename: K O
authors.initials: KO
authors.lastname: Lim
authors.forename: E V
authors.initials: EV
authors.lastname: Sullivan
authors.forename: B
authors.initials: B
authors.lastname: Lane
authors.forename: D
authors.initials: D
authors.lastname: Spielman
mesh_terms: D000328:Adult; D061085:Agenesis of Corpus Callosum; D001927:Brain Diseases / Q000378:metabolism*; D003337:Corpus Callosum / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011522:Protons
chemical_list: D011522:Protons