[Short- and long-term evaluation of treatment of critical ischemia of the lower lim with PGE1 (alprostadyl alpha-cyclodestrine)].
Twenty-five patients affected by chronic lower limb obliterating arteriopathy with critical ischemia in one limb were treated with PGE1 for 4 weeks and then followed-up for one year. On day 14 of treatment three groups of patients were selected on the basis of clinical symptoms and instrumental tests; patients were subdivided into Responders, Partial Responders and Non-Responders. The results obtained were satisfactory in view of the fact that the selection into three groups enabled Partial Responders to be reclassified, in some cases by repeating the treatment cycle.
Amitrano
M
M
Divisione di Medicina Generale, S. Giuseppe Moscati- Avellino.
Izzo
M
M
Castaldo
G
G
Lombardi
R
R
Tizzano
R
R
Bellizzi
A M
AM
Vietri
G C
GC
Sorrentino
A
A
D'Avanzo
A
A
D000368:Aged; D000369:Aged, 80 and over; D000527:Alprostadil / Q000008:administration & dosage / Q000627:therapeutic use*; D001157:Arterial Occlusive Diseases / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007511:Ischemia / Q000188:drug therapy*; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D000527:Alprostadil
Valutazione a breve e lungo termine del trattamento con PGE1 (alprostadil alpha-ciclodestrina) nell'ischemia critica degli arti inferiori.