title: Genetic effects of binazine and hydralazine in vitro and in vivo.
abstract: The mutagenic and genotoxic activities of binazine and hydralazine were studied. In the Ames test, both with and without S-9 fraction, hydralazine was mutagenic in strains Salmonella typhimurium TA100 and TA1537, whereas binazine was not mutagenic in these strains. Both drugs were negative in mice micronucleus test.
authors.affiliation: Drug Institute, Warsaw, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Chłopkiewicz
authors.forename: A
authors.initials: A
authors.lastname: Ejchart
authors.forename: J
authors.initials: J
authors.lastname: Marczewska
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000633:toxicity*; D006830:Hydralazine / Q000633:toxicity*; D008297:Male; D051379:Mice; D009153:Mutagens / Q000633:toxicity*; D014032:Todralazine / Q000633:toxicity*
chemical_list: D000959:Antihypertensive Agents; D009153:Mutagens; D006830:Hydralazine; D014032:Todralazine