title: Dominant inhibition of intercellular communication by two chimeric connexins.
abstract: 1. The physiological significance of communication through gap junction channels has been difficult to assess because channel activity cannot be experimentally modulated in a specific manner. To address this problem we have constructed chimeric connexins that function as dominant-negative inhibitors of intercellular channel activity.
authors.affiliation: Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Goliger
authors.forename: R
authors.initials: R
authors.lastname: Bruzzone
authors.forename: T W
authors.initials: TW
authors.lastname: White
authors.forename: D L
authors.initials: DL
authors.lastname: Paul
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000187:drug effects*; D017630:Connexins / Q000235:genetics* / Q000494:pharmacology*; D004594:Electrophysiology; D005354:Fibrosarcoma; D051379:Mice; D008845:Microinjections; D009865:Oocytes / Q000502:physiology; D011993:Recombinant Fusion Proteins / Q000494:pharmacology*; D014162:Transfection; D014407:Tumor Cells, Cultured; D014981:Xenopus
chemical_list: D017630:Connexins; D011993:Recombinant Fusion Proteins