title: [Saturated heterocyclic compounds. 216 (1). Synthesis, structure and ring opening of trans-perhydro-1,4-benzoxazepin-3-one derivatives].
abstract: trans-Perhydro-1,4-benzoxazepin-3-ones 2a-e were synthesized and transformed to condensed-skeleton perhydro-trans-1,4-benzoxazepines 3a,b, the thiones 4a,b, the urea derivatives 5a,b, and N-acylated compounds 6a-e. Compounds 6b,d were ring-opened by hydrochloride acid in ethanol to yield trans-2 (1-carbethoxyethoxy)-1-(acylaminomethyl)-cyclohexane derivatives 7b,d. The 1H- and 13C-nmr investigation and X-ray analysis of 5b and 6c,d proved that the expected N-acylated derivatives were formed and that both rings of the annolated compounds have a chair conformation.
authors.affiliation: Szent-Gyorgyi Albert Orvostudomanyi Egyeten, Gyogyszerkemiai Intezet, Szeged.
authors.forename: L
authors.initials: L
authors.lastname: Simon
authors.forename: F
authors.initials: F
authors.lastname: Fülöp
authors.forename: G
authors.initials: G
authors.lastname: Bernáth
authors.forename: G
authors.initials: G
authors.lastname: Argay
authors.forename: A
authors.initials: A
authors.lastname: Kálmán
authors.forename: P
authors.initials: P
authors.lastname: Sohár
mesh_terms: D000107:Acetylation; D007202:Indicators and Reagents; D008958:Models, Molecular; D015394:Molecular Structure; D010077:Oxazepines / Q000138:chemical synthesis / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D007202:Indicators and Reagents; D010077:Oxazepines
vernacular_title: Telített heterociklusok, 216 [1]. Transz-Perhidro-1, 4-benzoxazepin-3-on származékok szintézise és gyürüfelnyílása.