[Kikuchi-Fujimoto necrotizing histiocytic lymphadenitis: apropos of 2 cases and review of the literature].
The Kikuchi-Fujimoto's syndrome is an histiocytic necrotizing lymphadenitis which is observed at any ages but preferentially among young adults. The sex ratio is about 4:1 in favour of women. It is clinically characterized by cervical lymph nodes in a context of fever and asthenia. Sometimes, there is transitory leucopenia and an increase of the erythrocyte sedimentation rate. The course of the disease is spontaneously favourable in 1 or 3 months but recurrence is possible. The histology of the lymph node could mimic a malignant lymphoma and the immunohistochemical findings are of a great importance (Ki-M1P or KP1 antibody). The etiology remains unknown but some infectious diseases have been suspected (toxoplamosis, Epstein-Barr virus). Its association with a systemic lupus erythematous had been described and this set the problem of its physiopathology. We report two new cases of Kikuchi-Fujimoto's syndrome which one was attributed to Epstein-Barr virus primo-infection and the other associated with a systemic lupus erythematous.
Sire
S
S
Clinique médicale et des maladies infectieuses, CHU Bordeaux, hôpital Pellegrin, Bordeaux, France.
Djossou
F
F
Deminière
C
C
Constans
J
J
Ragnaud
J M
JM
Aubertin
J
J
D000328:Adult; D005260:Female; D006644:Histiocytes; D006801:Humans; D008199:Lymphadenitis / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D009336:Necrosis
Adénite histiocytaire nécrosante de Kikuchi-Fujimoto: a propose de deux cas et revue de la littérature.