Actions of adrenomedullin on the rat adrenal cortex.
The actions of adrenomedullin on cAMP and aldosterone secretion have been investigated using an intact rat adrenal capsular preparation incubated in vitro. Adrenomedullin was found to cause a dose-dependent increase in aldosterone secretion, with a parallel increase in cAMP release. The minimum concentration of adrenomedullin required for significant stimulation of aldosterone secretion was 10nmol/l. Adrenomedullin did not affect ACTH-stimulated aldosterone secretion, but significantly inhibited endothelin-1 stimulated aldosterone secretion. We conclude that adrenomedullin is an aldosterone stimulant in the rat adrenal gland, acting through cAMP generation.
Kapas
S
S
Department of Oral Pathology, St Bartholomew, London.
Hinson
J P
JP
D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D053607:Adrenomedullin; D000450:Aldosterone / Q000378:metabolism; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D019332:Endothelin-1 / Q000494:pharmacology; D005260:Female; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000494:pharmacology*
D019332:Endothelin-1; D010455:Peptides; D014665:Vasodilator Agents; D053607:Adrenomedullin; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D000242:Cyclic AMP