The influence of estrogens, progesterone and their antagonists on the collagen content in the pregnant rat uterus.
The influence of progesterone, estrogens and their antagonists: mifepristone and tamoxifen on connective tissue metabolism in pregnant rat uterus near term was evaluated. Total collagen and its soluble fraction as well as water concentration was measured in a population of 65 pregnant rats; treated with progesterone (n = 10), mifepristone (n = 13), estradiol (n = 17) and tamoxifen (n = 12). The results suggest the important influence of sex steroids on the uterine connective tissue metabolism during pregnancy.
Bieńkiewicz
A
A
Department of Pathophysiology, Medical University of Lódź, Poland.
Welfel
J
J
Kuś
E
E
D000818:Animals; D003094:Collagen / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006727:Hormone Antagonists / Q000494:pharmacology; D015735:Mifepristone / Q000494:pharmacology*; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013629:Tamoxifen / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism
D006727:Hormone Antagonists; D013629:Tamoxifen; D015735:Mifepristone; D011374:Progesterone; D004958:Estradiol; D003094:Collagen