The immunology of Eta-1/osteopontin.
The cytokine Eta-1/osteopontin is secreted by activated macrophages and may constitute the most abundant molecule secreted by activated T-lymphocytes. It causes macrophages to migrate and suppress production of reactive oxygen species. It enhances generation of immunoglobulins or proliferation of B-lymphocytes. Its biochemical characteristics suggest that Eta-1/osteopontin may be the T-lymphocyte suppressor factor. The apparently conflicting effects on individual immune functions may reflect homeostatic mechanisms.
Weber
G F
GF
Dana-Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
Cantor
H
H
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000818:Animals; D001161:Arteriosclerosis / Q000276:immunology / Q000378:metabolism; D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism*; D001402:B-Lymphocytes / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology*; D018177:Flavivirus Infections / Q000276:immunology; D005921:Glomerulonephritis / Q000276:immunology / Q000378:metabolism; D006801:Humans; D009000:Monocytes / Q000378:metabolism; D053495:Osteopontin; D010586:Phagocytes / Q000276:immunology; D012795:Sialoglycoproteins / Q000276:immunology* / Q000378:metabolism* / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
C506895:SPP1 protein, human; D012795:Sialoglycoproteins; D053495:Osteopontin