[Apoptosis and cancer].
Apoptosis is a form of cell death in which the cell actively participates by providing molecules that are directly or indirectly involved in the process and by providing energy for the process to proceed. Apoptosis is a fundamental process which is controlled at the genetic and molecular levels, and as such can be analyzed, understood and manipulated. Cell death in which there is a chromatin condensation prior to damage of cytoplasmic organelles and to disruption of the cell membrane is apoptotic. Apoptosis plays an important role in the regulation of tissue growth, the inhibition of transformation in normal cell and in the control of cancer. A failure of blockade of the apoptotic mechanism is a prerequisite for cancer. Currently, it may not be practical to treat patients with antisense oligonucleotides that target antiapoptosis genes, although such treatments may become available in the future.
Romanenko
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AM
D017209:Apoptosis; D002455:Cell Division / Q000502:physiology; D002471:Cell Transformation, Neoplastic; D053938:DNA Fragmentation; D006801:Humans; D009369:Neoplasms / Q000473:pathology* / Q000648:ultrastructure
Apoptoz i rak.