title: On the value of menorrhagia as a predictor for coagulation disorders.
abstract: The value of menorrhagia as a predictor for mild bleeding disorders has been very little studied and the results are divergent. In the present study on 30 women with objectively verified menorrhagia, we found a significantly increased prevalence of von Willebrand's disease (20%). By keeping a strict sampling and laboratory routine, and by restricting sampling to cycle days 5-7, we also obtained a very low interindividual variation of von Willebrand factor and coagulation factor VIII. We conclude that menorrhagia is a valuable predictor for coagulation and platelet disorders, and that time of sampling is of importance. This should be considered in the investigation of menorrhagia, and can be a guideline in looking for mild bleeding disorders.
authors.affiliation: Department of Woman and Child Health, Karolinska Hospital, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Edlund
authors.forename: M
authors.initials: M
authors.lastname: Blombäck
authors.forename: B
authors.initials: B
authors.lastname: von Schoultz
authors.forename: O
authors.initials: O
authors.lastname: Andersson
mesh_terms: D000328:Adult; D001772:Blood Cell Count; D001778:Blood Coagulation Disorders / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D001780:Blood Coagulation Tests; D001798:Blood Proteins / Q000032:analysis; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006467:Hemophilia A / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D008595:Menorrhagia / Q000209:etiology*; D008875:Middle Aged; D015995:Prevalence; D014842:von Willebrand Diseases / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology
chemical_list: D001798:Blood Proteins; D006454:Hemoglobins