title: The neostriatal mosaic: basis for the changing distribution of neurokinin-1 receptor immunoreactivity during development.
abstract: The pattern of neurokinin-1 receptor-like immunoreactivity (NK-1Rir) was mapped in perinatal and adult mouse striatum by using a new polyclonal antiserum. NK-1Rir was detected in the differentiating regions of the ganglionic eminences on embryonic day 12.5 (E12.5). NK-1Rir structures were enriched in the striatal patch compartment between E16.5 and approximately postnatal day 3 (P3); distributed more uniformly, within portions of both the patch and matrix compartments on P7; and enriched in the matrix compartment in the adult. Analysis of the phenotype of NK-1Rir cells on P2, P7, and in the adult suggested that cholinergic cells accounted for the majority of NK-1Rir cells early postnatally, with increasing contributions from somatostatinergic cells later postnatally. In the adult, approximately half of NK-1Rir cells were cholinergic and half were somatostatinergic. The transient enrichment of NK-1R-bearing cells and processes in the patch compartment which contains cells that express substance P (SP), a putative ligand for the NK-1R, may be a consequence of compartment formation or may be functionally important for compartment development.
authors.affiliation: Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: A A
authors.initials: AA
authors.lastname: Ardelt
authors.forename: V V
authors.initials: VV
authors.lastname: Karpitskiy
authors.forename: J E
authors.initials: JE
authors.lastname: Krause
authors.forename: K A
authors.initials: KA
authors.lastname: Roth
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000918:Antibody Specificity; D016466:CHO Cells / Q000502:physiology; D006224:Cricetinae; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D018613:Microscopy, Confocal; D008969:Molecular Sequence Data; D017072:Neostriatum / Q000737:chemistry / Q000196:embryology* / Q000378:metabolism*; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D018040:Receptors, Neurokinin-1 / Q000032:analysis / Q000276:immunology* / Q000378:metabolism*; D014162:Transfection
chemical_list: D018040:Receptors, Neurokinin-1