title: Weak expression of blood type B antigen in kidney tissue and successful B-incompatible kidney transplantation without special treatments.
abstract: Much attention has been paid to only natural antibody titer of the recipients in ABO-incompatible kidney transplantation. In this study, we looked at the distribution of blood type antigens in the kidney tissue. Thirty-seven biopsy specimens from patients with nephritis or transplanted kidneys were recruited. Fifteen were type A, 14 were type B, and 8 were type AB. Kidney tissues were stained with anti-A or anti-B antibody using immunohistological staining. The stained dots in each section were regarded as the area and were measured by image analyzer. B antigen was expressed very weakly both in the glomeruli and in interstitium as compared with A antigen. In type AB, B antigen was less expressed than A antigen. Based on these results, we performed B-incompatible kidney transplantation. No rejection was seen without preoperative depletion of natural antibody and splenectomy. These results may suggest that type B-incompatible kidney transplantation might possibly be performed without preoperative depletion of natural antibodies.
authors.affiliation: Department of Surgery, Saitama Medical School, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Koyama
authors.forename: Y
authors.initials: Y
authors.lastname: Taguchi
authors.forename: S
authors.initials: S
authors.lastname: Sugahara
authors.forename: N
authors.initials: N
authors.lastname: Akimoto
authors.forename: R
authors.initials: R
authors.lastname: Omoto
mesh_terms: D000017:ABO Blood-Group System / Q000032:analysis / Q000276:immunology*; D000328:Adult; D001787:Blood Group Incompatibility / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male
chemical_list: D000017:ABO Blood-Group System