title: Detection of ehrlichial antigen in plasma of beagle dogs with experimental acute Ehrlichia canis infection.
abstract: Six beagles were experimentally infected with Ehrlichia canis. All dogs developed typical clinical signs of ehrlichiosis and sero-converted. Ehrlichial antigenemia in the plasma of the infected dogs was detected using a sandwich enzyme-linked immunosorbent assay (ELISA). Ehrlichial antigen was present starting 15-20 days post-infection, after the development of clinical signs and antibody titre to Ehrlichia canis. The appearance of ehrlichial antigen in the plasma for a relatively short and variable period after the clinical and haematological signs, limits its potential as an early diagnostic prognosticator of canine ehrlichiosis.
authors.affiliation: Life Science Research Israel, Ness Ziona, Israel.
authors.forename: T
authors.initials: T
authors.lastname: Waner
authors.forename: M
authors.initials: M
authors.lastname: Rosner
authors.forename: S
authors.initials: S
authors.lastname: Harrus
authors.forename: A
authors.initials: A
authors.lastname: Naveh
authors.forename: R
authors.initials: R
authors.lastname: Zass
authors.forename: A
authors.initials: A
authors.lastname: Keysary
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000097:blood*; D004283:Dog Diseases / Q000175:diagnosis* / Q000382:microbiology; D004285:Dogs; D004536:Ehrlichia / Q000276:immunology* / Q000302:isolation & purification; D016873:Ehrlichiosis / Q000175:diagnosis / Q000382:microbiology / Q000662:veterinary*; D004797:Enzyme-Linked Immunosorbent Assay; D013997:Time Factors
chemical_list: D000942:Antigens, Bacterial