title: Signaling by extracellular nucleotides.
abstract: ATP and other nucleotides can be released from cells through regulated pathways, or following the loss of plasma membrane integrity. Once outside the cell, these compounds take on new roles as intercellular signaling molecules that elicit a broad spectrum of physiological responses through the activation of numerous cell surface receptor subtypes. This review summarizes recent advances in the molecular characterization of ATP receptors and discusses roles for cloned receptors in established and novel physiological processes.
authors.affiliation: Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143-0450, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Brake
authors.forename: D
authors.initials: D
authors.lastname: Julius
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane; D006801:Humans; D008969:Molecular Sequence Data; D009711:Nucleotides / Q000502:physiology*; D018048:Receptors, Purinergic P2 / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D009711:Nucleotides; D018048:Receptors, Purinergic P2