Effect of sevoflurane anaesthesia on plasma concentrations of glutathione S-transferase.
To assess the effect of sevoflurane anaesthesia on hepatocellular integrity, we measured plasma concentrations of glutathione S-transferase (GST) before anaesthesia and 1, 3, 6 and 24 h after the end of anaesthesia in 41 healthy, Japanese patients undergoing elective, body surface surgery. Sevoflurane (approximately 1.0 MAC) was delivered in 50-66% nitrous oxide in oxygen via a circle system, with a fresh gas flow of 6 litre min-1. Ventilation was spontaneous in all patients. Mean duration of anaesthesia was 101 min. Concentrations of GST increased significantly 1 h after the end of anaesthesia (P = 0.0075), but this was not significantly different from preoperative concentrations at 3, 6 and 24 h. Three patients developed a large secondary increase in GST concentrations at 24 h. The increase observed at 1 h was probably a result of reduced total liver blood flow; the mechanism for the secondary increase at 24 h is unclear but the possibility that products of sevoflurane biotransformation are responsible cannot be excluded.
Ray
D C
DC
Department of Anaesthetics, Royal Infirmary, Edinburgh.
Bomont
R
R
Mizushima
A
A
Kugimiya
T
T
Forbes Howie
A
A
Beckett
G J
GJ
D000328:Adult; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D004987:Ethers / Q000494:pharmacology*; D005982:Glutathione Transferase / Q000097:blood*; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008738:Methyl Ethers; D008875:Middle Aged; D011184:Postoperative Period; D000077149:Sevoflurane
D018685:Anesthetics, Inhalation; D015415:Biomarkers; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D005982:Glutathione Transferase