title: Pharmacological properties of traditional medicines. XXII. Pharmacokinetic study of mulberroside A and its metabolites in rat.
abstract: To identify the active components in Mori Cortex (Chinese medicine), Mori Cortex extracts were administered orally to rats, and then blood plasma, urine, and bile were analyzed. The results showed only a few remaining metabolites of mulberroside A. Consequently, to clarify the transitional properties of mulberroside A derivatives to tissues and the in vivo abundance ratio of mulberroside A compounds, the pharmacokinetics of mulberroside A derivatives were investigated in this study. When Mori Cortex extracts were administered orally, mulberroside A was only detected in small quantities in the plasma, and its bioavailability was about 1%. This is due to the first pass effect, by which most mulberroside A was converted into oxyresveratrol and transported into the circulating blood, and its absorption ratio was estimated at about 50%. Oxyresveratrol was found to be transported to tissues at high rates. As a result, when analyzing the pharmacological activity of the Mori Cortex in vitro, it is more useful to study oxyresveratrol than mulberroside A.
authors.affiliation: Department of Kampo Medicinal Science, Hokkaido College of Pharmacy, Otaru, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Qiu
authors.forename: K
authors.initials: K
authors.lastname: Komatsu
authors.forename: K
authors.initials: K
authors.lastname: Saito
authors.forename: K
authors.initials: K
authors.lastname: Kawasaki
authors.forename: X
authors.initials: X
authors.lastname: Yao
authors.forename: Y
authors.initials: Y
authors.lastname: Kano
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004365:Drugs, Chinese Herbal