Reactivation of recipient antibody to blood cell antigens soon after allogeneic bone marrow transplantation.
Reactivation of recipient antibody to HLA and red blood cell antigens is described in 8 patients after allogeneic bone marrow transplantation. These IgG antibodies can be detected between day 10 and day 40 after transplantation and, in 1 patient, can be shown to be antigen-independent. We hypothesize that, induced by graft recognition of recipient antigens, antigen-independent activation of sensitized recipient B cells takes place leading to transient antibody production.
Wernet
D
D
Department of Transfusion Medicine, University Hospital, Tübingen, Germany.
Schnaidt
M
M
Northoff
H
H
D000906:Antibodies / Q000097:blood / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D016026:Bone Marrow Transplantation / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male; D014184:Transplantation, Homologous
D000906:Antibodies; D006680:HLA Antigens; D007074:Immunoglobulin G