Resistance to activated protein C: role in venous and arterial thrombosis.
Activated protein C resistance is the most prevalent cause of thrombophilia: it is found in 20 to 30% of patients with a deep venous thrombosis history. Activated protein C resistance is due to an arginine 506 to glutamine mutation in factor V. This mutation prevents normal inactivation of activated factor V by activated protein C. The estimated increase in relative risk of venous thrombosis is 5- to 10-fold in heterozygotes, and 50- to 100-fold in homozygotes. Activated protein C resistance does not seem to play a role in arterial thrombosis and in the occurrence of myocardial infarction.
Emmerich
J
J
Service de Médecine Vasculaire, Centre Claude Bernard de Recherche sur les Maladies Vasculaires Périphériques, Hôpital Broussais, Paris, France.
Alhenc-Gelas
M
M
Aiach
M
M
Fiessinger
J N
JN
D000328:Adult; D000368:Aged; D004789:Enzyme Activation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000235:genetics / Q000378:metabolism*; D013924:Thrombophlebitis / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism*; D013927:Thrombosis / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism*
D011486:Protein C