Enhanced calcium response to serotonin in platelets from patients with affective disorders.
In this report we have investigated the intracellular calcium (Ca2+) mobilization mediated by serotonin 5-HT2A receptors in the platelets of 13 patients with bipolar disorder and 12 patients with major depression in comparison with 15 healthy control subjects. We found an enhanced intracellular Ca2+ rise in response to 5-HT in platelets from both bipolar patients and patients with major depression. The 5-HT2A receptor-mediated intracellular Ca2+ signaling mechanism may have an important role in the pathophysiology of affective disorders.
Yamawaki
S
S
Department of Psychiatry and Neurosciences, Hiroshima University, School of Medicine, Japan.
Kagaya
A
A
Okamoto
Y
Y
Shimizu
M
M
Nishida
A
A
Uchitomi
Y
Y
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D002118:Calcium / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000097:blood / Q000378:metabolism*; D012701:Serotonin / Q000097:blood*
D012701:Serotonin; D002118:Calcium