Expression pattern of activation and adhesion molecules on peripheral blood CD4+ T-lymphocytes in relapsing-remitting multiple sclerosis patients: a serial analysis.
We studied the expression of various cell surface molecules (CD25, CD28, CD29, CD45RO, CD56, LFA-1, VLA-4) on peripheral blood CD4+ T-cells in 6 relapsing-remitting multiple sclerosis (RR-MS) patients. Furthermore, changes in the expression pattern of these surface markers during intervals of increased disease activity, which was measured by gadolinium (Gd-DTPA) magnetic resonance imaging (MRI) were examined. Although several patients showed signs of increased disease activity during the observation period, this was not paralleled by a relevant change in the expression of these activation and adhesion molecules.
Stüber
A
A
Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1400, USA.
Martin
R
R
Stone
L A
LA
Maloni
H
H
McFarland
H F
HF
D000328:Adult; D015703:Antigens, CD / Q000378:metabolism*; D001921:Brain / Q000473:pathology; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000097:blood*; D002469:Cell Separation; D005260:Female; D005434:Flow Cytometry; D019786:Gadolinium DTPA; D006801:Humans; D008213:Lymphocyte Activation; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology*; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA