title: Molecular cloning and sequencing of a novel human P2 nucleotide receptor.
abstract: A novel human P2 nucleotide receptor has been cloned from a T-cell cDNA library. The predicted amino acid sequence shows characteristics of a G-protein-coupled receptor, and shares 88% homology with a recently characterised rat P2 nucleotide receptor sequence. Distinctive features include an extremely short cytoplasmic tail with only one putative protein kinase C phosphorylation site. Northern blot analysis revealed a 1.9 kb transcript expressed in the placenta.
authors.affiliation: Department of Pathology, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia.
authors.forename: M C
authors.initials: MC
authors.lastname: Southey
authors.forename: F
authors.initials: F
authors.lastname: Hammet
authors.forename: A M
authors.initials: AM
authors.lastname: Hutchins
authors.forename: M
authors.initials: M
authors.lastname: Paidhungat
authors.forename: G R
authors.initials: GR
authors.lastname: Somers
authors.forename: D J
authors.initials: DJ
authors.lastname: Venter
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics*; D019204:GTP-Binding Proteins; D006801:Humans; D008969:Molecular Sequence Data; D009928:Organ Specificity; D012333:RNA, Messenger / Q000032:analysis; D018048:Receptors, Purinergic P2 / Q000235:genetics*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D013601:T-Lymphocytes
chemical_list: D018076:DNA, Complementary; D012333:RNA, Messenger; D018048:Receptors, Purinergic P2; C099845:purinoceptor P2Y6; D019204:GTP-Binding Proteins