Effect of oxytocin on growth hormone release in vitro.
The effect of oxytocin (OT) on growth hormone (GH) secretion was investigated using dispersed rat anterior pituitary cells. OT dose-dependently inhibited GH secretion as well as GHRH-stimulated GH release. The inhibitory actions of OT on GH release were totally abolished by pretreatment with the OT-antagonist VAP 259. The peptides galanin and cholecystokinin did not affect the OT-induced inhibition on basal or GHRH-stimulated GH release. Several possible mechanisms by which OT may influence GH release are discussed.
Hulting
A L
AL
Department of Endocrinology, Karolinska Hospital, Stockholm, Sweden.
Grenbäck
E
E
Pineda
J
J
Coya
R
R
Hökfelt
T
T
Meister
B
B
Uvnäs-Moberg
K
K
D000818:Animals; D002478:Cells, Cultured; D019004:Galanin / Q000494:pharmacology; D013006:Growth Hormone / Q000378:metabolism*; D006727:Hormone Antagonists / Q000494:pharmacology; D008297:Male; D010121:Oxytocin / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012844:Sincalide / Q000494:pharmacology; D013268:Stimulation, Chemical
D006727:Hormone Antagonists; C104764:VAP 259; D010121:Oxytocin; D019004:Galanin; D013006:Growth Hormone; D012844:Sincalide