Jun: transcription factor and oncoprotein.
Since the discovery of v-jun as the transforming protein of the sarcoma virus 17 three mammalian homologues of v-jun have been isolated. All three jun genes respond to a multitude of agents, and the encoded proteins in turn bind to and regulate, positively or negatively, the transcription of dependent genes, thereby influencing cellular fate. In addition, through transcription factor "cross-talk" Jun influences the transcription of genes regulated by different classes of transcription factors, such as steroid hormone receptors. Although the role of Jun proteins in transcriptional regulation has been thoroughly analyzed in recent years, the role of Jun proteins in oncogenesis is still poorly understood.
Rahmsdorf
H J
HJ
Forschungszentrum Karlsruhe, Institut für Genetik, Germany.
D001665:Binding Sites; D003001:Cloning, Molecular; D005786:Gene Expression Regulation / Q000235:genetics; D016350:Leucine Zippers / Q000235:genetics; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism; D011499:Protein Processing, Post-Translational / Q000235:genetics; D016755:Proto-Oncogene Proteins c-jun / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism*
D016755:Proto-Oncogene Proteins c-jun; D014157:Transcription Factors; D011494:Protein Kinases