title: Clinical applications of proton therapy.
abstract: Proton therapy offers considerable potential advantages in the management of poorly resectable, radio-resistent tumors close to critical anatomical structures. So far over 15,000 patients have been treated worldwide with two major indications: conservative management of ocular melanomas in which local control exceeds 95% at 5 years and curative irradiation of sarcomas at the base of the skull and cervical canal, with a survival rate between 84 and 94% at 5 years. The different protocols tested currently worldwide are discussed.
authors.affiliation: Centre de Protonthérapie d'Orsay, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Habrand
authors.forename: P
authors.initials: P
authors.lastname: Schlienger
authors.forename: L
authors.initials: L
authors.lastname: Schwartz
authors.forename: D
authors.initials: D
authors.lastname: Pontvert
authors.forename: C
authors.initials: C
authors.lastname: Lenir-Cohen-Solal
authors.forename: S
authors.initials: S
authors.lastname: Helfre
authors.forename: H
authors.initials: H
authors.lastname: Mammar
authors.forename: C
authors.initials: C
authors.lastname: Haie-Meder
authors.forename: R
authors.initials: R
authors.lastname: Ferrand
authors.forename: A
authors.initials: A
authors.lastname: Mazal
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000532:radiotherapy; D001932:Brain Neoplasms / Q000532:radiotherapy; D002985:Clinical Protocols; D017357:Cyclotrons; D005134:Eye Neoplasms / Q000532:radiotherapy; D006258:Head and Neck Neoplasms / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008545:Melanoma / Q000532:radiotherapy; D008875:Middle Aged; D009369:Neoplasms / Q000532:radiotherapy*; D011522:Protons; D011882:Radiotherapy, High-Energy / Q000379:methods*; D013125:Spinal Neoplasms / Q000532:radiotherapy; D016019:Survival Analysis
chemical_list: D011522:Protons