[Long-term effects of inhaled beta 2-agonists on bronchial hyperresponsiveness in asthmatics].
We examined the effects of two year's treatment of three inhaled beta 2-agonists (beta 2), such as salbutamol (S), procaterol (P) and fenoterol (F) on acetylcholine induced bronchial hyperresponsiveness (BHR) in mild approximately moderate asthmatics. When symptomatic use of beta 2 were less than 6 puffs/day, BHR was improved significantly with both S and P but was not with F. When more than 6 puffs/day, all three beta 2 did not show the improvement of BHR. Without the effect of corticosteroids, BHR was improved with S, and was partially improved with P in case of only less than 6 puffs/day, but was not improved with F unrelated to the inhaled puff number. Therefore, frequent use of beta 2 even if used only on demand was shown to worse BHR, asthmatics must be controlled to under the good condition of using beta 2 at least less than 6 puffs/day.
Ogawa
C
C
Department of Allergy and Respiratory Medicine, Doai Memorial Hospital.
Sano
Y
Y
D000284:Administration, Oral; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage* / Q000009:adverse effects; D000420:Albuterol / Q000008:administration & dosage* / Q000009:adverse effects; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D016535:Bronchial Hyperreactivity; D005280:Fenoterol / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D017265:Procaterol / Q000008:administration & dosage* / Q000009:adverse effects
D000318:Adrenergic beta-Agonists; D005280:Fenoterol; D000420:Albuterol; D017265:Procaterol