title: Successful treatment with fluconazole of protothecosis developing at the site of an intralesional corticosteroid injection.
abstract: We report a case of cutaneous protothecosis treated successfully with oral fluconazole. Fluconazole appears to be an effective alternative to conventional drugs for the treatment of cutaneous protothecosis. Cutaneous protothecosis is an uncommon infection due to achlorophyllic, saprophytic, algae-like unicellular organisms of the genus Prototheca that occurs mainly in immunocompromised patients. To date there is no standard treatment regimen. Surgical excision, oral ketoconazole, intravenous amphotericin B alone or in combination with oral tetracycline have been reported to be effective in the management of protothecosis. We report a 55-year-old immunocompetent woman with cutaneous protothecosis which developed at the site of intralesional triamcinolone acetonide injection, who was successfully treated with oral fluconazole.
authors.affiliation: Department of Dermatology, Kosin Medical College, Pusan, South Korea.
authors.forename: S T
authors.initials: ST
authors.lastname: Kim
authors.forename: K S
authors.initials: KS
authors.lastname: Suh
authors.forename: Y S
authors.initials: YS
authors.lastname: Chae
authors.forename: Y J
authors.initials: YJ
authors.lastname: Kim
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D007239:Infections / Q000188:drug therapy; D008875:Middle Aged; D011525:Prototheca; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole