title: Saccharomyces cerevisiae mitochondria lack a bacterial-type sec machinery.
abstract: The bacterial Sec genes encode a generalized protein export machinery. Although the mitochondria present in eukaryotic cells are derived from bacterial ancestors, a comprehensive search of the complete genomic sequence for the eukaryotic yeast Saccharomyces cerevisiae did not reveal any close homologs of the bacterial Sec genes, strongly suggesting that yeast mitochondria lack a generalized bacterial-type export system. This finding has implications for the sorting of imported mitochondrial proteins to the intermembrane space compartment, and also for the insertion of mitochondrially encoded proteins into the inner membrane.
authors.affiliation: Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637, USA. bsglick@midway.uchicago.edu
authors.forename: B S
authors.initials: BS
authors.lastname: Glick
authors.forename: G
authors.initials: G
authors.lastname: Von Heijne
mesh_terms: D001692:Biological Transport; D004271:DNA, Fungal / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics*; D005656:Fungal Proteins / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics; D026901:Membrane Transport Proteins; D008928:Mitochondria / Q000235:genetics*; D000069816:SEC Translocation Channels; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins
chemical_list: D004271:DNA, Fungal; D004272:DNA, Mitochondrial; D005656:Fungal Proteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D000069816:SEC Translocation Channels; C084005:SSS1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins