title: Neither protein kinase C nor adenylate cyclase are altered in the striatum from subjects with schizophrenia.
abstract: Dopamine (DA) D2 receptors which act by modulating second messenger pathways that include protein kinase C (PKC) and adenylate cyclase (AC) have been repeatedly shown to be increased in striatum from subjects with schizophrenia. Therefore it seemed possible that chronic up-regulation of DA-D2 receptors in the schizophrenic brain could result in a change in either of these two proteins. Hence we measured PKC and AC in striatum from 20 schizophrenic subjects and 20 non-schizophrenic subjects by quantitative autoradiography and could show no difference in the density of either PKC (436 +/- 35 vs. 485 +/- 29 fmol/mg tissue equivalents (TE), mean +/- SEM) or AC (77 +/- 9 vs. 80 +/- 7 fmol/mg TE) in the tissue from schizophrenic compared to the non-schizophrenic subjects. Thus, these data do not support the hypothesis that PKC or AC are changed in the schizophrenic brain.
authors.affiliation: Rebecca L. Cooper Laboratories, Mental Health Research Institute of Victoria, Parkville, Australia.
authors.forename: K
authors.initials: K
authors.lastname: Opeskin
authors.forename: B
authors.initials: B
authors.lastname: Dean
authors.forename: G
authors.initials: G
authors.lastname: Pavey
authors.forename: C
authors.initials: C
authors.lastname: Hill
authors.forename: N
authors.initials: N
authors.lastname: Keks
authors.forename: D
authors.initials: D
authors.lastname: Copolov
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D000328:Adult; D000368:Aged; D001345:Autoradiography; D003342:Corpus Striatum / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011493:Protein Kinase C / Q000378:metabolism*; D012016:Reference Values; D012559:Schizophrenia / Q000201:enzymology* / Q000473:pathology; D012565:Schizophrenic Psychology
chemical_list: D011493:Protein Kinase C; D000262:Adenylyl Cyclases