title: Could oral erythromycin optimize high energy continuous enteral nutrition?
abstract: BACKGROUND
  Intravenous erythromycin has previously been reported to stimulate gastric emptying, to inhibit gastric acid secretion and to stimulate pancreatic secretion during continuous gastric infusion of a liquid diet in healthy volunteers.
  
  
  OBJECTIVE
  The aim of this study was to evaluate the effects of oral erythromycin (160 mg/h) on gastrointestinal function under these conditions in seven healthy subjects.
  
  
  METHODS
  This randomized double-blind cross-over study measured the gastric emptying rate of nutrients, gastric acid secretion, gastric pH, jejunal flow rate as well as biliopancreatic secretion and duodeno-caecal transit time during a 19.9 kJ/min continuous infusion of a nutrient solution (4.18 kJ/mL) in the antrum over a 6-h period by a perfusion method.
  
  
  RESULTS
  The nutrition was well tolerated except by one subject with placebo perfusion. During the 6-period, total gastric volume and gastric volume of nutrient decreased during erythromycin administration by 22 +/- 8 and 22 +/- 6%, respectively. Gastric acid secretion was not modified by erythromycin. Lipase and bile salt outputs were significantly higher with erythromycin. The duodeno-caecal transit time was not statistically different with drug and placebo (169 +/- 15 and 146 +/- 19 min, respectively).
  
  
  CONCLUSIONS
  During continuous gastric infusion of a liquid diet, the effect of oral erythromycin on gastric emptying could be useful to optimize cyclic enteral nutrition or to enhance the tolerance of enteral nutrition.
authors.affiliation: Laboratoire de Pharmacie Galénique, Faculté de Pharmacie, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Landry
authors.forename: N
authors.initials: N
authors.lastname: Vidon
authors.forename: P
authors.initials: P
authors.lastname: Sogni
authors.forename: P
authors.initials: P
authors.lastname: Nepveux
authors.forename: J C
authors.initials: JC
authors.lastname: Chaumeil
authors.forename: D
authors.initials: D
authors.lastname: Couturier
authors.forename: S
authors.initials: S
authors.lastname: Chaussade
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001659:Biliary Tract / Q000187:drug effects / Q000378:metabolism; D002432:Cecum / Q000502:physiology; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004386:Duodenum / Q000502:physiology; D004750:Enteral Nutrition / Q000379:methods*; D004917:Erythromycin / Q000494:pharmacology*; D005746:Gastric Emptying / Q000187:drug effects; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D005772:Gastrointestinal Transit / Q000187:drug effects; D006801:Humans; D008049:Lipase / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism
chemical_list: D005765:Gastrointestinal Agents; D004917:Erythromycin; D008049:Lipase