[The effect of prostaglandin E1 on choleresis in the rat liver after relief of biliary obstruction].
The effect of prostaglandin E1 on bile excretion was investigated using the ex vivo perfused rat liver. In the control group (normal liver), the perfusion system was stabilized 60 minutes after the induction of the perfusion and the effect of administered prostaglandin E1 was most markedly observed at the concentration of 2.5 micrograms/l. The effects of prostaglandin E1 on the liver with biliary obstruction was investigated on 14 days after the induction of biliary obstruction when the obstruction was spontaneously resolved by recanalization of the obstructed bile duct. Both portal blood flow and bile excretion increased significantly in the PGE1 (+) group, perfused with perfusate containing 2.5 micrograms/l of prostaglandin E1, compared to the PGE1 (-) group. However, there was no significant difference between the PGE1 (+) and the PGE1 (-) in excretion of total bile acid. The c-AMP level of perfusate increased by the administration of prostaglandin E1. It was concluded that prostaglandin E1 increased portal blood flow and bile acid-independent bile flow in the liver after relief of biliary obstruction.
Ikeda
T
T
Second Department of Surgery, Mie University School of Medicine.
D000527:Alprostadil / Q000494:pharmacology*; D000818:Animals; D001646:Bile / Q000502:physiology*; D002779:Cholestasis / Q000503:physiopathology*; D008099:Liver / Q000187:drug effects; D008297:Male; D010477:Perfusion; D011168:Portal System / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D000527:Alprostadil