title: Sofalcone for treatment of Helicobacter pylori infection.
abstract: It is difficult to regard sofalcone as a single drug for the treatment of Helicobacter pylori infection. However, sofalcone exerts multiple effects against H. pylori: it has antibacterial activity, induces morphological changes, inhibits adhesion to gastric mucin and inhibits lipolytic activity. The safety profile of sofalcone even on long-term administration is well established. Therefore, it may be possible to establish a new triple therapy for H. pylori infection using sofalcone combined with antibacterial drugs and proton pump inhibitors.
authors.affiliation: Second Department of Internal Medicine, Oita Medical University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Fujioka
authors.forename: K
authors.initials: K
authors.lastname: Murakami
authors.forename: T
authors.initials: T
authors.lastname: Kubota
authors.forename: R
authors.initials: R
authors.lastname: Kodama
authors.forename: S
authors.initials: S
authors.lastname: Honda
authors.forename: M
authors.initials: M
authors.lastname: Nasu
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002599:Chalcone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D047188:Chalcones; D004359:Drug Therapy, Combination; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D047188:Chalcones; C035032:sofalcone; D002599:Chalcone