title: Gadolinium enhancement: improved MRI detection of retinoblastoma extension into the optic nerve.
abstract: We performed T1-, T2-, proton density-weighted, and T1-weighted gadolinium-enhanced MRI on 24 patients with retinoblastoma, using a 1.5 T superconducting unit and head and orbital surface coil imaging. All patients underwent a complete ophthalmologic examination, including B-scan ultrasonography. CT was performed on 10 of 24 patients. Pathologic correlation was obtained in 18 patients who required enucleation. Contrast-enhanced T1-weighted MRI with fat suppression was the sequence most sensitive to optic nerve extension and provided the greatest differentiation between tumor and uninvolved extrascleral tissue. Retinoblastoma demonstrated contrast enhancement.
authors.affiliation: Department of Ophthalmology, Madigan Army Medical Center, Fort Lewis, WA 98431, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Ainbinder
authors.forename: B G
authors.initials: BG
authors.lastname: Haik
authors.forename: D F
authors.initials: DF
authors.lastname: Frei
authors.forename: K L
authors.initials: KL
authors.lastname: Gupta
authors.forename: M F
authors.initials: MF
authors.lastname: Mafee
mesh_terms: D002648:Child; D003390:Cranial Nerve Neoplasms / Q000175:diagnosis*; D005134:Eye Neoplasms / Q000175:diagnosis*; D005682:Gadolinium; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D008297:Male; D009900:Optic Nerve / Q000473:pathology*; D012175:Retinoblastoma / Q000175:diagnosis*
chemical_list: D005682:Gadolinium