Progress in the field of compounds for boron neutron capture therapy.
For successful application of boron neutron capture therapy to the treatment of cancer, selective accumulation of boron is required. This can be achieved by the preparation of suitable substances, which must contain boron and at the same time accumulate or be retained in tumor tissue. The radiobiological rationale for selection of suitable compounds is discussed. Examples of useful new compounds are given for which boronated analogues exist.
Gabel
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Department of Chemistry, University of Bremen, Germany.
D001896:Boron Compounds / Q000493:pharmacokinetics / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy; D004307:Dose-Response Relationship, Radiation; D005858:Germany; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D014018:Tissue Distribution
D001896:Boron Compounds