Glutamine, lymphocyte proliferation and cytokine production.
The present in vitro study was conducted to examine how glutamine influences the lymphocyte function. Glutamine had no effect on the production of interleukin-1 beta, interleukin-6 or tumour necrosis factor-alpha, but influenced the production of interleukin-2 and interferon-gamma. Glutamate, leucine, isoleucine and valine (substrates for glutamine production), or the combination of glutamate and leucine, did not influence the lymphocyte proliferative response or the cytokine production. In conclusion, glutamine influenced the production of some T-cell-derived cytokines, and is thereby important for optimal lymphocyte proliferation. Furthermore, the results show that lymphocytes are not capable of producing glutamine.
Rohde
T
T
Copenhagen Muscle Research Centre, Department of Infectious Diseases, Rigshospitalet, University Hospital, Denmark.
MacLean
D A
DA
Klarlund Pedersen
B
B
D002455:Cell Division; D002478:Cells, Cultured; D003470:Culture Media; D016207:Cytokines / Q000276:immunology*; D018698:Glutamic Acid / Q000494:pharmacology; D005973:Glutamine / Q000187:drug effects*; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology; D007375:Interleukin-1 / Q000276:immunology; D007376:Interleukin-2 / Q000276:immunology; D015850:Interleukin-6 / Q000276:immunology; D007930:Leucine / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D003470:Culture Media; D016207:Cytokines; D007375:Interleukin-1; D007376:Interleukin-2; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D005973:Glutamine; D018698:Glutamic Acid; D007371:Interferon-gamma; D007930:Leucine