title: Twenty years' delay of fellow eye involvement in herpes simplex virus type 2-associated bilateral acute retinal necrosis syndrome.
abstract: OBJECTIVE
  To describe a case of acute retinal necrosis with concurrent encephalitis and determine the causative virus. The patient had a history of presumed acute retinal necrosis in the left eye at the age of 8 years and recurrent genital herpes.
  
  
  METHODS
  Diagnostic anterior chamber puncture of the eye and lumbar puncture for laboratory analysis.
  
  
  RESULTS
  Polymerase chain reaction identified herpes simplex virus type 2 in the eye, and local antibody production to herpes simplex virus was demonstrated in the aqueous of this eye and in the cerebrospinal fluid.
  
  
  CONCLUSIONS
  Herpes simplex virus type 2 may cause bilateral acute retinal necrosis with long delay of fellow eye involvement and concurrent encephalitis.
authors.affiliation: Department of Ophthalmology, University of Amsterdam, The Netherlands. 101773.2052@compuserve.com
authors.forename: R O
authors.initials: RO
authors.lastname: Schlingemann
authors.forename: M
authors.initials: M
authors.lastname: Bruinenberg
authors.forename: P
authors.initials: P
authors.lastname: Wertheim-van Dillen
authors.forename: E
authors.initials: E
authors.lastname: Feron
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D000998:Antiviral Agents / Q000627:therapeutic use; D001082:Aqueous Humor / Q000821:virology; D002555:Cerebrospinal Fluid / Q000821:virology; D003131:Combined Modality Therapy; D004279:DNA, Viral / Q000032:analysis; D018792:Encephalitis, Viral / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D015828:Eye Infections, Viral / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006558:Herpes Genitalis / Q000209:etiology; D006561:Herpes Simplex / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D018258:Herpesvirus 2, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D053685:Laser Therapy; D016133:Polymerase Chain Reaction; D012008:Recurrence; D015882:Retinal Necrosis Syndrome, Acute / Q000175:diagnosis / Q000628:therapy / Q000821:virology*
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents; D004279:DNA, Viral; D000212:Acyclovir