Interaction of Salmonella typhi strains with cultured human monocyte-derived macrophages.
Human monocyte-derived macrophages (MDM) provided this laboratory with a tool to develop a primary-cell assay for evaluating the relative virulence of newly constructed Salmonella typhi carrier strains. In this study, the interaction with and survival within MDM were compared for delta aroA143-attenuated strains, wild-type virulent strains, and the current oral-vaccine strain, Ty21a.
Sizemore
D R
DR
Department of Bacterial Diseases, Walter Reed Army Institute of Research, Washington, D.C. 20307-5100, USA.
Elsinghorst
E A
EA
Eck
L C
LC
Branstrom
A A
AA
Hoover
D L
DL
Warren
R L
RL
Rubin
F A
FA
D016915:AIDS Vaccines; D006801:Humans; D008264:Macrophages / Q000382:microbiology*; D009000:Monocytes / Q000382:microbiology*; D012485:Salmonella typhi / Q000472:pathogenicity*; D013045:Species Specificity; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic
D016915:AIDS Vaccines; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic