[The effect of calcium-regulating hormones on pain sensitivity in rats].
Analgesic effect of calcitonin administered in doses of 1, 3, and 5 U/100 g was studied in rats. Intrathecal administration of calcitonin (0.015 U) results in higher increase in analgesic effect compared to intraventricular injection. Intramuscular (1, 3, and 5 U/100 g) and intraventricular (0.1 U) injection of parathormone exert no analgesic effect, whereas intrathecal injection in a dose of 0.1 U resulted in statistically significant analgesia. High correlation was found for nociception and calcium level in blood. Nifedipine and isoptin (1, 5, and 10 mg/kg) were shown to reduce significantly the analgesic effect of calcitonin. On the membrane of the isolated neuron of mollusk calcitonin (10(-9) - 10(-7) M) increased and in a concentration of 10(-6) M decreased JCa. Inhibiting effect of isoptin on JCa was found for combined action of calcitonin and isoptin on the neuron membrane.
Butakov
S S
SS
Ignatov
Iu D
IuD
D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002116:Calcitonin / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004558:Electric Stimulation; D066298:In Vitro Techniques; D007276:Injections, Intraventricular; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D008974:Mollusca; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D017288:Pain Threshold / Q000187:drug effects*; D010281:Parathyroid Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D000700:Analgesics; D010281:Parathyroid Hormone; D002116:Calcitonin
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