[Spectrum of the renal pathology in HIV infection: description of 85 autopsies and clinico-pathologic correlation].
A descriptive cross-sectional study was conducted on the prevalence and histologic characteristics of renal lesions found in the autopsies of 85 patients with HIV infection: also, a retrospective analysis of clinico-biological characteristics in 56 of these patients in order to establish the factors associated with the histological findings. A total of 85 autopsies were made from 1985 to 1993; 50 autopsies (58.8%) showed renal changes: 23 (27%) infections, 13 (15.2%) acute tubular necrosis (ATN), 6 (7%) tumors, 5 (5.8%) intersticial nephritis (IN), 5 (5.8%) nephrocalcinosis (NC), 10 (11.7%) others. In an additional study: group IIc (n = 37, study group with nephropathy) had a higher incidence in the hepatitis B surface marker (HBsAg) than in group Ic (n = 19, control group, without nephropathy) (0 vs 10, p < 0.05). The presence of disseminated mycobacteriosis in the autopsy was significantly higher in the group with nephropathy than in the group without nephropathy (11 vs 1, p < 0.05). No consistent data were observed between the clinical diagnosis of nephropathy and autopsic findings. In summary, a high incidence of nephropathy was found in the autopsies of HIV infected patients, although it was not previously suspected. Renal lesions in autopsies of HIV infected patients had a tubular-intersticial predominance over glomerular lesions. The use of potentially nephrotoxic drugs, the presence of HBsAG, and some opportunist infections apparently influenced on the development of renal lesions among these patients.
Martínez Hernández
P L
PL
Servicio de Medicina Interna, Hospital Universitario La Paz, Universidad Autónoma de Madrid.
Peña Sánchez de Rivera
J M
JM
Arnalich Fernández
F
F
García Viera
M
M
Madridano Cobo
O
O
González García
J
J
Fernández-Capitán
C
C
Vázquez Rodríguez
J J
JJ
D016263:AIDS-Associated Nephropathy / Q000150:complications / Q000453:epidemiology / Q000473:pathology*; D000328:Adult; D001344:Autopsy; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007239:Infections / Q000382:microbiology; D008297:Male; D015995:Prevalence; D013030:Spain / Q000453:epidemiology
El espectro de la patología renal en la infección por el VIH: descripción de 85 autopsias y correlación clínico-patológica.