title: Is beta-APP a marker of axonal damage in short-surviving head injury?
abstract: beta-Amyloid precursor protein (beta-APP), a normal constituent of neurons which is conveyed by fast axonal transport, has been found to be a useful marker for axonal damage in cases of fatal head injury. Immunocytochemistry for beta-APP is a more sensitive technique for identifying axonal injury than conventional silver impregnation. This study was designed to determine how quickly evidence of axonal damage and bulb formation appears. Using this method a variety of brain areas were studied from 55 patients who died within 24 h of a head injury. Immunocytochemical evidence of axonal injury was first detected after 2 h survival, axonal bulbs were first identified after 3 h survival, and the amount of axonal damage and axonal bulb formation increased the longer the survival time.
authors.affiliation: Department of Neuropathology, University of Glasgow, UK.
authors.forename: K J
authors.initials: KJ
authors.lastname: McKenzie
authors.forename: D R
authors.initials: DR
authors.lastname: McLellan
authors.forename: S M
authors.initials: SM
authors.lastname: Gentleman
authors.forename: W L
authors.initials: WL
authors.lastname: Maxwell
authors.forename: T A
authors.initials: TA
authors.lastname: Gennarelli
authors.forename: D I
authors.initials: DI
authors.lastname: Graham
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D001369:Axons / Q000473:pathology*; D015415:Biomarkers; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D006259:Craniocerebral Trauma / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008875:Middle Aged; D016019:Survival Analysis
chemical_list: D016564:Amyloid beta-Protein Precursor; D015415:Biomarkers