title: Inhibitory effect of the topical administration of a bisphosphonate (risedronate) on root resorption incident to orthodontic tooth movement in rats.
abstract: Root resorption associated with tooth movement is an unsolved problem in orthodontics. If such root resorption could be prevented, it would be an important contribution toward reducing risk factors in orthodontic treatment. The purpose of this study was to examine the effects of the topical administration of a bisphosphonate, risedronate, which is known to be a potent blocker of bone resorption, on root resorption during tooth movement and on the repair of the resorbed root surface after tooth movement in rats. In the first experiment, both the right and left upper first molars were moved buccally with a standardized expansion spring under administration of risedronate. After day 7, extensive root resorption had occurred on the control side, and the area of root resorption reached a maximum on day 14. The topical administration of risedronate caused a significant and dose-dependent inhibition of root resorption after the orthodontic force was applied. In the second experiment, the right and left upper molars were first moved buccally for 3 weeks. Risedronate treatment began on the day the spring was removed. After the force was withdrawn, the resorbed root surfaces on both the control and risedronate-treated sides were gradually restored by apposition of repair cementum (cementoid). The topical administration of risedronate did not appear to inhibit the repair process of root resorption. These results suggest that the topical administration of risedronate may be useful in preventing root resorption of teeth during orthodontic treatment.
authors.affiliation: Department of Orthodontics, School of Dentistry, Tohoku University, Sendai, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Igarashi
authors.forename: H
authors.initials: H
authors.lastname: Adachi
authors.forename: H
authors.initials: H
authors.lastname: Mitani
authors.forename: H
authors.initials: H
authors.lastname: Shinoda
mesh_terms: D000287:Administration, Topical; D000704:Analysis of Variance; D000818:Animals; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D012968:Etidronic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D010010:Osteoclasts / Q000187:drug effects / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D000068296:Risedronic Acid; D012391:Root Resorption / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D013997:Time Factors; D014087:Tooth Movement Techniques / Q000009:adverse effects* / Q000379:methods; D014092:Tooth Root / Q000187:drug effects / Q000473:pathology
chemical_list: D000068296:Risedronic Acid; D012968:Etidronic Acid