[Effect of lomefloxacin on the synthesis of antibodies to vaccine EV fraction I and hemagglutinins].
Multifactor analysis of the lomefloxacin effect on the primary immune response to T-independent bacterial antigen (vaccine EV fraction 1) and to T-dependent cellular antigen (SRBC) in mice was performed with the use of a wide range of the antibiotic concentrations and the dosage time. It was shown that lomefloxacin in the doses corresponding to the average therapeutic ones used for 3-9 days had no effect on the content of the IgG antibodies, was able to increase the level of the IgM antibodies and insignificantly lowered the concentration of the IgA antibodies.
Iordanova
A I
AI
Navashin
P S
PS
Smolkina
T V
TV
Nikitin
A V
AV
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000942:Antigens, Bacterial / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D024841:Fluoroquinolones; D006388:Hemagglutinins / Q000276:immunology*; D007114:Immunization; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007136:Immunoglobulins / Q000096:biosynthesis*; D051379:Mice; D015363:Quinolones / Q000494:pharmacology*; D012756:Sheep
D000890:Anti-Infective Agents; D000942:Antigens, Bacterial; D024841:Fluoroquinolones; D006388:Hemagglutinins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D015363:Quinolones; C053091:lomefloxacin
Vliianie lomefloksatsina na sintez antitel k I fraktsii vaktsiny EV i gemaggliutininov.