Exposure of piglet coronary arterial muscle cells to low alcohol results in elevation of intracellular free Ca2+: relevance to fetal alcohol syndrome.
Chronic exposure of cultured piglet neonatal coronary arterial smooth muscle cells to low concentrations of ethanol (46-115 mg/dl) for 7 days resulted in concentration-dependent elevation in intracellular free Ca2+ ions ([Ca2+i); these rises (22-56%) in [Ca2+]i were not reversible upon short-term exposure to normal, Ca2(+)-containing physiological salt solution. These findings help to provide a rational basis for why ethanol can result in the well-known fetal alcohol syndrome, including cardiac defects and in-utero death.
Altura
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MB
Department of Physiology, State University of New York, Health Science Center at Brooklyn 11203, USA.
Zhang
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A
Cheng
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Altura
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BT
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D003329:Coronary Vasospasm / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D003331:Coronary Vessels / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D063647:Fetal Alcohol Spectrum Disorders / Q000378:metabolism*; D005311:Fetal Hypoxia / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control; D066298:In Vitro Techniques; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D017202:Myocardial Ischemia / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control; D013552:Swine
D000431:Ethanol; D002118:Calcium