title: [Combined treatment with resection, intraoperative hypotonic and post-operative systemic chemotherapy using cis-platinum for a mediastinal yolk sac tumor: a case report].
abstract: Generally yolk sac tumor in the mediastinum is a rare and highly malignant neoplasm. We report a case of yolk sac tumor, which was treated with resection, and then intraoperative hypotonic and postoperative systemic chemotherapy. A 33-year-old man was diagnosed as a mediastinal tumor with chest X-ray and chest CT findings. At operation he had mediastinal tumor which invaded to the part of the right upper lobe and pericardium, disseminated on the right diaphragm. A large tumor was removed with partial pericardiectomy and wedge resection of the right upper lobe. After resection hypotonic chemotherapy with cis-platinum was performed. This tumor had endodermal sinus structure, Schiller-Duval body, and eosinophilic hyaline globolus which were histological characteristics of yolk sac tumor, and the value of serum alpha-fetoprotein (AFP) was high. After operation with this diagnosis systemic chemotherapy consisted of cis-platinum, etoposide were performed. Patient was discharged uneventfully 8 months later.
authors.affiliation: Department of Surgery, School of Medicine, Fukuoka University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Matsuo
authors.forename: T
authors.initials: T
authors.lastname: Shirakusa
authors.forename: K
authors.initials: K
authors.lastname: Kawahara
authors.forename: A
authors.initials: A
authors.lastname: Iwasaki
authors.forename: H
authors.initials: H
authors.lastname: Okabayashi
authors.forename: T
authors.initials: T
authors.lastname: Shiraishi
mesh_terms: D000328:Adult; D002945:Cisplatin / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D018240:Endodermal Sinus Tumor / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D007038:Hypotonic Solutions / Q000008:administration & dosage; D008297:Male; D008479:Mediastinal Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*
chemical_list: D007038:Hypotonic Solutions; D002945:Cisplatin