[Possible connection between the level of heterozygosity of biochemical gene markers in patients with lung diseases].
The comparative heterozygosity level was estimated in patients suffering from squamous epithelial lung cancer (SELC) and in patients with chronic pneumonia with bronchiectases. To estimate heterozygosity, seven loci, reflecting normal diversity in human populations, were used (HP, TF, GC, PI, GL01, ACP1, PGM1). SELC patients with an uncomplicated postoperative period were distinguished by an increase in the level of observed heterozygosity (Hzero = 0.3916) in comparison with the theoretically expected value (H(e) = 0.4361). Patients having chronic pneumonia with bronchiectases with a complicated postoperative period were distinguished by an increase in the observed and expected level of heterozygosity (Hzero = 0.3737, H(e) = 0.3837) in comparison with that in the patient cohort with an uncomplicated postoperative period. The Wright's fixation index had a high value in the SELC cohort with an uncomplicated postoperative period (F = 0.1073) and a low value in patients with complicated cases (0.0048), witnessing the polar divergence of those patients from the total group of patients (0.0598) and the control (0.0388). The D criterion, reflecting deviation from the maximum heterozygosity level, distinguished the SELC patient cohort with a complicated postoperative period from patients with uncomplicated cases by the HP, GC, and ACP1 loci. The D criterion distinguished the SELC patients from the healthy control groups by the PGM1 locus.
Spitsyn
V A
VA
Agapova
R K
RK
Tsybikova
E B
EB
Afanas'eva
I S
IS
Perel'man
M I
MI
Bochkov
N P
NP
D000328:Adult; D000368:Aged; D001987:Bronchiectasis / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D002908:Chronic Disease; D015331:Cohort Studies; D005819:Genetic Markers; D006579:Heterozygote; D006801:Humans; D008171:Lung Diseases / Q000235:genetics*; D008175:Lung Neoplasms / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000235:genetics
D005819:Genetic Markers
Vozmozhnaia sviaz' mezhdu urovnem geterozigotnosti po biokhimicheskim markeram genov u bol'nykh s legochnoĭ patologieĭ.