Study on clinical immunity in patients with coronary artery disease.
The study was designed to assess the change in humoral immunity in patients with coronary artery disease (CAD). In 42 patients with CAD and 40 healthy controls, the serum levels of IgG, IgA, IgM and complement C3 were measured by simple immune diffusion. The results showed that: (1) the serum levels of IgG in patients with CAD were significantly higher than those in controls (14.14 +/- 2.77 g/L vs 10.16 +/- 2.86 g/L p < 0.01); (2) the serum levels of complement C3 in patients with CAD were higher than those in controls (1.52 +/- 0.67 g/L vs 1.28 +/- 0.53 g/L p < 0.05); and (3) no statistical difference in serum levels of IgA and IgM between the two groups was found. The results suggest that there was an enhanced humoral immune action in patients with CAD, and immune injury may be an important factor in the pathogenetic mechanism of CAD.
Tao
M
M
Department of Cardiology, Wuhan Railway Central Hospital, China.
D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000097:blood / Q000276:immunology*; D005260:Female; D006801:Humans; D007109:Immunity; D007136:Immunoglobulins / Q000097:blood; D008297:Male; D008875:Middle Aged
D007136:Immunoglobulins