[The possible mechanisms of the antioxidant action of calcium channel blockers in the hypoxic syndrome].
The influence of calcium channel blockers on pro-oxidant-antioxidant balance in hypoxic syndrome is studied. Both verapamil and cinnarizine were shown to prevent formation and accumulation of lipid peroxidation products in the tissues and normalize the basic components of the system of antioxidant protection. Probable mechanisms of the antioxidant action of the calcium channel blockers are discussed.
Savchenko
L V
LV
Dzuban
E M
EM
Luk'ianchuk
V D
VD
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002936:Cinnarizine / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D000860:Hypoxia / Q000188:drug therapy* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013577:Syndrome; D013997:Time Factors; D014700:Verapamil / Q000627:therapeutic use*
D000975:Antioxidants; D002121:Calcium Channel Blockers; D002936:Cinnarizine; D014700:Verapamil
Vozmozhnye mekhanizmy antioksidantnogo deĭstviia blokatorov kal'tsievykh kanalov pri gipoksicheskom sindrome.