Serum protein electrophoresis as a prognostic marker of chronic liver disease in dogs.
In a previous study in dogs with chronic liver disease it was found that a combination of clinical features and laboratory findings was useful in differentiating liver diseases but could not be used to evaluate a dog's prognosis. When an electrophoretic analysis of the serum proteins was included, marked decreases in the concentrations of albumin and the alpha-globulins alpha-1-antitrypsin and haptoglobin were observed in terminal liver cirrhosis, indicating impaired liver function. However, low albumin concentrations, together with normal or increased concentrations of alpha-1-antitrypsin and haptoglobin, were observed in dogs which, although severely depressed when examined, often recovered and survived for a year or more.
Sevelius
E
E
Small Animal Clinic, Animal Hospital of Helsingborg, Sweden.
Andersson
M
M
D000510:Alpha-Globulins / Q000032:analysis; D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D001798:Blood Proteins / Q000032:analysis*; D002908:Chronic Disease; D004283:Dog Diseases / Q000097:blood* / Q000503:physiopathology; D004285:Dogs; D004586:Electrophoresis / Q000379:methods / Q000662:veterinary; D006242:Haptoglobins / Q000032:analysis; D008107:Liver Diseases / Q000097:blood / Q000503:physiopathology / Q000662:veterinary*; D011379:Prognosis; D012709:Serum Albumin / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis
D000510:Alpha-Globulins; D015415:Biomarkers; D001798:Blood Proteins; D006242:Haptoglobins; D012709:Serum Albumin; D000515:alpha 1-Antitrypsin