title: Amifostine (Ethyol): dosing, administration and patient management guidelines.
abstract: Cytoprotection utilising amifostine (Ethyol, WR-2721) is an evolving strategy to protect normal cells from the toxicity of chemotherapy. The dosing and administration guidelines are reviewed. The recommended dose of amifostine is 910 mg/m2 as a 15-min infusion prior to chemotherapy. Toxicity of this agent is moderate with hypotension and nausea/vomiting being observed in variable numbers of patients. Administration of amifostine with chemotherapy is simple and is associated with acceptable toxicity.
authors.affiliation: Cleveland Clinic Foundation, Department of Hematology/Oncology, Cleveland Clinic Cancer Center, Ohio 44195-5237, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Bukowski
mesh_terms: D004999:Amifostine / Q000008:administration & dosage* / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D004334:Drug Administration Schedule; D006801:Humans; D007022:Hypotension / Q000139:chemically induced / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents; D004999:Amifostine