[The tyrosine kinase inhibitor genistein potentiates the antidiuretic effect of vasopressin and its analogs].
Genistein was shown to potentiate the effects of all the activators of the water flow except the cAMP action. The thyrosine kinase (TK) seems to suppress the hydrosmotic action of arginine vasopressin at the period preceding the cAMP formation and to potentiate this effect afterwards.
Bagrov
Ia Iu
IaIu
Dmitrieva
N I
NI
Manusova
N B
NB
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D004357:Drug Synergism; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D019833:Genistein; D066298:In Vitro Techniques; D007529:Isoflavones / Q000494:pharmacology*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D011896:Rana temporaria; D012076:Renal Agents / Q000494:pharmacology*; D019311:Staurosporine / Q000494:pharmacology; D001743:Urinary Bladder / Q000187:drug effects / Q000378:metabolism; D014667:Vasopressins / Q000494:pharmacology*; D014867:Water / Q000378:metabolism
D004791:Enzyme Inhibitors; D007529:Isoflavones; D012076:Renal Agents; D014867:Water; D014667:Vasopressins; D001127:Arginine Vasopressin; D019833:Genistein; D011505:Protein-Tyrosine Kinases; D011493:Protein Kinase C; D019311:Staurosporine
Ingibitor tirozinkinazy genistein usilivaet antidiureticheskiĭ éffekt vazopressina i ego analogov.