The influence of glycerol, propylene glycol and sorbitol on surface tension, partition coefficient and diffusion of pyrrolidinoethylester of 3-heptyloxy phenylcarbamic acid (drug XX Z).
The influence of glycerol, propylene glycol and sorbitol on surface tension, partition coefficient and diffusion of pyrrolidinoethylester of 3-heptyloxy phenylcarbamic acid (Drug XX Z) from solutions has been studied. It was found that each of the three mentioned auxiliary substances causes, proportionally to its concentration (5, 10, 15 and 20%), the increase of the surface tension and the decrease of the partition coefficient. A correlation between the surface tension and partition coefficient was proved. The diffusion of the drug XX Z was increased due to use of the auxiliary substances. With respect to these results and in accordance with the rules for development of the drug form, sorbitol in concentration 5-10% seems to be an optimal auxiliary substance.
Vitková
Z
Z
Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic.
Gardavská
K
K
Cizmárik
J
J
Rak
J
J
D000779:Anesthetics, Local / Q000737:chemistry*; D002219:Carbamates / Q000737:chemistry*; D005990:Glycerol / Q000737:chemistry*; D048448:Phenylcarbamates; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000737:chemistry*; D013012:Sorbitol / Q000737:chemistry*; D013500:Surface Tension
D000779:Anesthetics, Local; D002219:Carbamates; D048448:Phenylcarbamates; D011409:Propylene Glycols; C103106:drug XX Z; D013012:Sorbitol; D019946:Propylene Glycol; D005990:Glycerol