Influence of nicotine on gastrin and peptide YY in the rat.
The objective of this study was to examine the effects of nicotine and high-fat diets on gastrin and peptide YY (PYY) homeostasis in the rat. Antral levels of gastrin mRNA and peptide and ileal and colonic levels of PYY mRNA and peptide were examined. Serum levels of gastrin in response to food were also measured. Control rats were ad-lib fed or pair-fed according to the daily food intake of nicotine-treated rats. The results of this study indicate that nicotine treatment and fat diets can influence gastrin and PYY gene expression in the gastrointestinal tract.
Gomez
G
G
Department of Surgery, University of Texas Medical Branch, Galveston 77555-0725, USA.
Lambertz
I
I
Udupi
V
V
Qi
X
X
Thompson
J C
JC
Greeley
G H
GH
D000818:Animals; D015152:Blotting, Northern; D004032:Diet; D005223:Fats / Q000008:administration & dosage; D005755:Gastrins / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D015918:Infusion Pumps, Implantable; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D019894:Peptide YY; D010455:Peptides / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D011863:Radioimmunoassay; D051381:Rats; D017207:Rats, Sprague-Dawley; D012907:Smoking; D013270:Stomach / Q000187:drug effects*
D005223:Fats; D005755:Gastrins; D010455:Peptides; D012333:RNA, Messenger; D019894:Peptide YY; D009538:Nicotine