Natural history of central topographic islands following excimer laser photorefractive keratectomy.
OBJECTIVE
To assess the incidence and natural history of central corneal topographic islands following excimer laser photorefractive keratectomy (PRK) and photoastigmatic refractive keratectomy (PARK).


METHODS
A dedicated corneal diseases and refractive surgery unit within a National Health Service Trust ophthalmology unit in the United Kingdom.


METHODS
Corneal topographic analysis was performed in a prospective study of 100 eyes of 75 consecutive patients who had PRK. All PRK/PARK excimer laser photorefractive procedures were performed by two surgeons observing a standardized protocol using a VISX 20/20 excimer laser. Mean preoperative myopic error was 5.54 diopters (D) +/- 3.44 (SD). Corneal topographic analysis was performed on all eyes preoperatively, 1 week postoperatively, and monthly thereafter for a minimum of 6 months or until central islands, if present, resolved. All patients had a minimum 12 months follow-up.


RESULTS
Postoperatively, 29 eyes (29%) demonstrated central corneal topographic islands of greater than 3.00 D topographic power by computerized videokeratography (CVK). All central islands were identified in the first 4 weeks postoperatively. In all cases the differential dioptric power, created by the central islands within the ablation zone, decreased rapidly; within 6 months, 26 (90%) central islands had fully resolved without further treatment, and the remaining 3 (10%) resolved within 1 year of photorefractive surgery. The occurrence of central islands was related to higher preoperative myopic spherical equivalent (P = .01), greater attempted laser correction (P = .01), and greater projected depth of ablation (P = .01) (Student's two-tailed t-test).


CONCLUSIONS
Central corneal topographic islands occurred in a significantly higher proportion of eyes having excimer laser photorefractive surgery than previously believed. The islands were associated with decreased unaided vision, reduced best spectacle-corrected acuity, and other troublesome visual symptoms; however, the central islands, along with their associated visual effects, usually resolved without surgical intervention within 6 months postoperatively.
McGhee
C N
CN
Corneal Diseases and Excimer Laser Unit, Sunderland Eye Infirmary, United Kingdom.
Bryce
I G
IG
D000328:Adult; D000368:Aged; D001251:Astigmatism / Q000601:surgery*; D003315:Cornea / Q000473:pathology* / Q000601:surgery; D003316:Corneal Diseases / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D054018:Lasers, Excimer; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000601:surgery*; D018903:Photorefractive Keratectomy / Q000009:adverse effects*; D011183:Postoperative Complications / Q000209:etiology / Q000473:pathology; D011446:Prospective Studies