title: A ground-based animal model of space adaptation syndrome.
abstract: We examined the effect and aftereffect of acute or chronic load of hypergravity produced by an animal centrifuge, on pica (that is, kaolin intake) in the rat as an index of motion sickness. Although the degree of pica initially induced by acute or chronic hypergravity was not different, the rate of decline of increased kaolin intake over poststimulus days was different. Pica after a 1-h load of 2g decreased rapidly. On the other hand, pica lasted 3 days after a 48-h load of 2g. These findings suggest that the aftereffects of chronic hypergravity application on pica are due to motion sickness induced by readaptation to normal gravity, and they support our idea that after adaptation to a hypergravity environment, return and readaptation to the normal gravity can simulate exposure and adaptation to microgravity. We concluded that motion sickness in rats induced by the aftereffects of chronic hypergravity stimulation can be used as a ground-based animal model of space adaptation syndrome.
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, Osaka University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Takeda
authors.forename: A
authors.initials: A
authors.lastname: Horii
authors.forename: A
authors.initials: A
authors.lastname: Uno
authors.forename: M
authors.initials: M
authors.lastname: Morita
authors.forename: T
authors.initials: T
authors.lastname: Mochizuki
authors.forename: A
authors.initials: A
authors.lastname: Yamatodani
authors.forename: T
authors.initials: T
authors.lastname: Kubo
mesh_terms: D000818:Animals; D002498:Centrifugation; D004195:Disease Models, Animal; D018471:Hypergravity / Q000009:adverse effects*; D007616:Kaolin / Q000008:administration & dosage; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018489:Space Motion Sickness / Q000209:etiology* / Q000473:pathology
chemical_list: D007616:Kaolin