[Catabolism of membrane phosphatidylcholines during early stages of mitogenic initiation of phosphoinositide cycle in lymphocytes].
Deacylation of the phosphatidylcholine fraction in plasma membranes of rat thymocytes and human blood lymphocytes was studied as well as its relationship to the activation of phosphoinositide-specific phosphodiesterase at early stages of mitogen-initiated phosphoinositide cycle. The data indicate that in lymphocyte membranes, enzymatic system of cascade deacylation of the phosphatidylcholine fraction includes calcium-activated phospholipase A1 and lysophospholipase. The enzyme system contributes to the rapid and reversible modification of the lipid bilayer of lymphocyte plasma membrane and can cooperate with phosphoinositide-specific phosphodiesterase during its activation at early stages of the initiation of phosphoinositide pathway during translocation of the external mitogenic signal.
Tadevosian
Iu V
IuV
Asatrian
L Iu
LIu
Batikian
T B
TB
Karagezian
K G
KG
Tadevosian
A Iu
AIu
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008214:Lymphocytes / Q000378:metabolism*; D008934:Mitogens / Q000494:pharmacology*; D010713:Phosphatidylcholines / Q000378:metabolism*; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D010716:Phosphatidylinositols / Q000378:metabolism*; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D051381:Rats
D008934:Mitogens; D010713:Phosphatidylcholines; D010716:Phosphatidylinositols; D003208:Concanavalin A; D010727:Phosphoric Diester Hydrolases; D043265:Phosphatidylinositol Diacylglycerol-Lyase
Katabolizm membrannykh fosfatidilkholinov v rannie sroki mitogennoĭ initsiatsii fosfoinozitidnogo tsikla v limfotsitakh.