Inability to attain oral anticoagulation: warfarin-rifampin interaction revisited.
The warfarin-rifampin interaction is a well-described but underappreciated drug interaction. A case is reported in which therapeutic anticoagulation could not be achieved after nearly 4 weeks of warfarin therapy because of simultaneous administration of rifampin. This patient had the highest warfarin clearance ever reported in the literature. The world's literature describing warfarin-rifampin interactions for the past 32 years was reviewed to suggest guidelines for warfarin dosage when rifampin is given simultaneously.
Casner
P R
PR
Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso 79905, USA.
D000328:Adult; D000904:Antibiotics, Antitubercular / Q000494:pharmacology*; D000925:Anticoagulants / Q000493:pharmacokinetics*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D012293:Rifampin / Q000494:pharmacology*; D014859:Warfarin / Q000493:pharmacokinetics*
D000904:Antibiotics, Antitubercular; D000925:Anticoagulants; D014859:Warfarin; D012293:Rifampin