title: Renal amyloidosis--a clinicopathologic study.
abstract: A total of 19,075 necropsies and 1169 renal biopsies were scrutinised over a period of 20 years (1973-1992) retrospectively with an aim to study the incidence and pattern of renal amyloidosis in Nair Hospital. A total of 75 cases with amyloidosis were detected, 33 from the necropsy series (0.162%) and 42 from biopsies (3.59%). Secondary amyloidosis was seen in 82.66% and primary amyloidosis in 10.66%. Tuberculosis of various organs was the main cause of secondary amyloidosis (79.03%). Nephrotic syndrome was the common mode of presentation (52%). Besides kidney, which were involved in all cases, the liver, spleen and adrenals were other commonly involved organs at necropsy. Renal failure was the leading cause of death (51.51%). Thioflavine-T proved to be more sensitive technique than other conventional staining methods. The potassium permanganate test is a useful test to distinguish secondary amyloid fibrils from other amyloid fibrils. Abdominal fat aspiration may prove to be specific, sensitive and a routine procedure enabling the early diagnosis of amyloidosis leading to increased incidence of amyloidosis during life than at necropsy.
authors.affiliation: B.Y.L. Nair Hospital, Bombay.
authors.forename: V B
authors.initials: VB
authors.lastname: Shah
authors.forename: A M
authors.initials: AM
authors.lastname: Phatak
authors.forename: B S
authors.initials: BS
authors.lastname: Shah
authors.forename: B M
authors.initials: BM
authors.lastname: Kandalkar
authors.forename: A R
authors.initials: AR
authors.lastname: Haldankar
authors.forename: S
authors.initials: S
authors.lastname: Ranganathan
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*; D008297:Male; D009404:Nephrotic Syndrome / Q000503:physiopathology; D051437:Renal Insufficiency / Q000401:mortality / Q000503:physiopathology; D014376:Tuberculosis / Q000150:complications