T cell involvement in glomerular injury.
The mechanisms of glomerular injury are multiple: one aspect is cell-mediated immunity in inflammatory kidney disease. Its fundamental role has been established within the last decade. T cells seem to play a regulatory role in the course of inflammation not only in the proliferative and crescentic disease, but also in nonproliferative glomerulonephritis. T cells become increasingly important in the pathogenesis of both glomerular and interstitial kidney diseases and seem to determine course and prognosis. The recent advances in understanding the mechanisms of T cell-mediated inflammation in kidney disease offer new approaches in therapy.
Merkel
F
F
Medizinische Klinik I, Hospital Cologne-Mertheim, Academic Hospital, University of Cologne, Germany.
Marx
M
M
Netzer
K O
KO
Weber
M
M
D007249:Inflammation / Q000276:immunology / Q000473:pathology; D007674:Kidney Diseases / Q000276:immunology / Q000473:pathology; D007678:Kidney Glomerulus / Q000276:immunology / Q000293:injuries / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology