title: Theoretical neurobiology and schizophrenia.
abstract: This chapter addresses the idea that schizophrenia is a 'disconnection syndrome' from a theoretical and computational perspective. The distinction between anatomical and functional connectivity is reviewed and used as a framework to introduce empirical and computational evidence that schizophrenia involves, at some level, a disintegration of neuronal interactions. The chapter concludes with an example of computational neuroscience that relates observations on the dimensional complexity of neuronal dynamics in schizophrenia to the disconnection hypothesis.
authors.affiliation: Wellcome Department of Cognitive Neurology, Institute of Neurology, London, UK.
authors.forename: K J
authors.initials: KJ
authors.lastname: Friston
mesh_terms: D001921:Brain / Q000473:pathology / Q000503:physiopathology; D001927:Brain Diseases / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D003198:Computer Simulation; D004569:Electroencephalography; D006801:Humans; D008959:Models, Neurological; D009446:Neurobiology; D012559:Schizophrenia / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology