title: Correlative evidence of hypertension and altered cochlear microhomeostasis: electrophysiological changes in the spontaneously hypertensive rat.
abstract: The spontaneously hypertensive rat model has been used to show that hypertension is an important pathophysiological risk factor in age-related hearing loss. In the present study, compound action potential (CAP), electrochemical potential (ECP), and potassium concentration (CK+) measurements were taken from the cochlea of genetically predisposed, spontaneously hypertensive rats (SHR) and from normotensive Wistar-Kyoto (WKY) rats. In the SHR model, as the duration of hypertension increased with the animal's age (from 3 to 8 months), CAP thresholds increased, ECP increased in marginal cells only, and CK+ increased in both endolymph and marginal cells. Collectively, the data suggest that ionic alternations of cellular potentials are involved in hearing changes in the hypertensive state. Ultimately, such data may assist in understanding hearing loss in individuals who are diagnosed with hypertension.
authors.affiliation: Department of Anatomy and Cell Biology, University of Florida, Gainesville 32610-0235, USA.
authors.forename: K E
authors.initials: KE
authors.lastname: Rarey
authors.forename: Y L
authors.initials: YL
authors.lastname: Ma
authors.forename: K J
authors.initials: KJ
authors.lastname: Gerhardt
authors.forename: M J
authors.initials: MJ
authors.lastname: Fregly
authors.forename: L C
authors.initials: LC
authors.lastname: Garg
authors.forename: L P
authors.initials: LP
authors.lastname: Rybak
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000375:Aging / Q000473:pathology*; D000704:Analysis of Variance; D000818:Animals; D001309:Auditory Threshold / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D002138:Calibration; D003051:Cochlea / Q000378:metabolism / Q000473:pathology*; D003055:Cochlear Microphonic Potentials / Q000502:physiology*; D004195:Disease Models, Animal; D004594:Electrophysiology; D006319:Hearing Loss, Sensorineural / Q000209:etiology*; D006706:Homeostasis; D006973:Hypertension / Q000503:physiopathology*; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
chemical_list: D011188:Potassium