Use of rocuronium in a pregnant patient with an open eye injury, receiving magnesium medication, for preterm labour.
We present a case where rocuronium 80 mg (3 x ED95) was used in a rapid sequence induction in a 80-kg pregnant patient with an open eye injury. The patient was also receiving magnesium 2 g h-1 i.v. for preterm labour. The expected duration for neuromuscular block of rocuronium in the absence of magnesium would be approximately 53 min; with infusion of magnesium, the duration of neuromuscular block was prolonged four-fold (215 min). It is important to remember that magnesium potentiates the effects of all non-depolarizing neuromuscular blocking agents, including rocuronium.
Gaiser
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Department of Anaesthesia, Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
Seem
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EH
D000328:Adult; D000732:Androstanols / Q000494:pharmacology*; D004357:Drug Synergism; D015807:Eye Injuries, Penetrating / Q000601:surgery; D005260:Female; D006801:Humans; D008274:Magnesium / Q000494:pharmacology* / Q000627:therapeutic use; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology*; D007752:Obstetric Labor, Premature / Q000188:drug therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000601:surgery; D000077123:Rocuronium; D015149:Tocolytic Agents / Q000494:pharmacology* / Q000627:therapeutic use
D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D015149:Tocolytic Agents; D008274:Magnesium; D000077123:Rocuronium