title: Cardiac perforation associated with continuous infusional chemotherapy.
abstract: The case history is reported of a 51-year-old man with metastatic colonic carcinoma who was receiving a continuous 5-fluorouracil infusion via a central venous catheter and who developed cardiac perforation and pericardial effusion. This complication has not previously been reported in association with continuous chemotherapy infusion.
authors.affiliation: Christie Hospital, Manchester, UK.
authors.forename: R A
authors.initials: RA
authors.lastname: Cooper
authors.forename: R D
authors.initials: RD
authors.lastname: James
authors.forename: K J
authors.initials: KJ
authors.lastname: Taylor
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology; D005472:Fluorouracil / Q000008:administration & dosage; D006335:Heart Injuries / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007260:Infusion Pumps / Q000009:adverse effects; D007262:Infusions, Intravenous / Q000009:adverse effects; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008297:Male; D008875:Middle Aged; D010490:Pericardial Effusion / Q000209:etiology
chemical_list: D000970:Antineoplastic Agents; D005472:Fluorouracil