title: Cd1a-positive cells in bronchoalveolar lavage samples from children with Langerhans cell histiocytosis.
abstract: We evaluated CD1a-positive cells in bronchoalveolar lavage samples from children with Langerhans cell histiocytosis (LCH). All children with multifocal LCH and pulmonary symptoms scored higher than 5% (30.6% +/- 7.2%), whereas those with other lung disorders scored much less than 5%. In children with multifocal LCH, bronchoalveolar lavage fluid abnormalities can precede pulmonary symptoms. During chemotherapy the CD1a-positive cell count lends to decrease.
authors.affiliation: Service de Pneumologie et d'Allergologie Pédiatriques, Hôpital Necker-Enfants Malades, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Réfabert
authors.forename: C
authors.initials: C
authors.lastname: Rambaud
authors.forename: T
authors.initials: T
authors.lastname: Mamou-Mani
authors.forename: P
authors.initials: P
authors.lastname: Scheinmann
authors.forename: J
authors.initials: J
authors.lastname: de Blic
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D018949:Antigens, CD1 / Q000032:analysis*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology / Q000276:immunology*; D002452:Cell Count; D002648:Child; D002675:Child, Preschool; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis*; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D008171:Lung Diseases / Q000175:diagnosis
chemical_list: D018949:Antigens, CD1