title: Psoriasis: pathophysiology and oral manifestations.
abstract: Psoriasis is a chronic, remitting and relapsing inflammatory skin disorder with a strong genetic predisposition. Psoriasis affects 1-3% of the world's population in their early lives representing a disabling condition with significant social and economic impact. Despite a great deal of research on the etiology and tissue destruction mechanisms, the disease is not well understood. The purpose of this paper is to provide current information from the literature with a special focus on oral manifestations. The major signs and symptoms presented in the oral environment of a psoriasis patient may include geographic tongue, fissure tongue, gingival and/or mucosal lesions. Inflammatory temporomandibular joint lesions have been reported in less than 5% of psoriasis patients. Multiple treatment strategies, be they topical or systemic, have been applied to these patients for symptom relief but not for cure.
authors.affiliation: Department of Pediatric Dentistry, University of Texas Health Science Center at San Antonio 78284-7888, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Zhu
authors.forename: M J
authors.initials: MJ
authors.lastname: Kaminski
authors.forename: D R
authors.initials: DR
authors.lastname: Pulitzer
authors.forename: J
authors.initials: J
authors.lastname: Hu
authors.forename: H F
authors.initials: HF
authors.lastname: Thomas
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000818:Animals; D002648:Child; D003937:Diagnosis, Differential; D005929:Glossitis, Benign Migratory / Q000209:etiology / Q000473:pathology / Q000628:therapy; D006801:Humans; D009059:Mouth Diseases / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D009061:Mouth Mucosa / Q000473:pathology; D009067:Mouthwashes / Q000627:therapeutic use; D011565:Psoriasis / Q000150:complications* / Q000473:pathology / Q000503:physiopathology*; D012307:Risk Factors; D013705:Temporomandibular Joint Disorders / Q000209:etiology; D014060:Tongue Diseases / Q000209:etiology* / Q000473:pathology / Q000628:therapy
chemical_list: D009067:Mouthwashes