title: [Acute rhabdomyolysis in status asthmaticus].
abstract: Acute rhabdomyolysis is a rare complication in patients with status asthmaticus receiving mechanical ventilation. Individual reports implicate several factors, whereby the simultaneous use of high-dose glucocorticoids and non-depolarizing muscle blocking agents appears to be the major patho-physiological mechanism. A 48 year-old female patient with a 3-year history of granulomatous vasculitis Churg-Strauss was admitted to the intensive care unit (ICU) due to severe status asthmaticus, which necessitated endotracheal intubation and mechanical ventilation. Antiobstructive therapy consisted of beta 2-sympathomimetics, theophylline and high-dose intravenous prednisolone (5440 mg in 10 days). Additionally, the patient was treated with non-depolarizing muscle blocking agents (atracurium 2070 mg over 7 days). Six days after admission to the ICU the patient developed severe rhabdomyolysis, with an increased creatine kinase (CK) level and myoglobinuria. The maximum CK value occurred 12 days after ICU admission (3810 U/l), accompanied by a serum myoglobin level of 13,900 ng/ml. 5 days after cessation of muscle relaxant therapy and reduction of intravenous glucocorticoids, the serum CK level decreased, reaching normal values 9 days later.
authors.affiliation: Klinik für Innere Medizin IV, Universität Wien.
authors.forename: E
authors.initials: E
authors.lastname: Eisenhuber
authors.forename: C
authors.initials: C
authors.lastname: Zauner
authors.forename: C
authors.initials: C
authors.lastname: Madl
authors.forename: L
authors.initials: L
authors.lastname: Kramer
authors.forename: K
authors.initials: K
authors.lastname: Ratheiser
mesh_terms: D000208:Acute Disease; D001279:Atracurium / Q000008:administration & dosage / Q000009:adverse effects*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000009:adverse effects; D003422:Critical Care; D004305:Dose-Response Relationship, Drug; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage / Q000009:adverse effects*; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects*; D012121:Respiration, Artificial; D012206:Rhabdomyolysis / Q000139:chemically induced*; D013224:Status Asthmaticus / Q000188:drug therapy*; D013806:Theophylline / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D001993:Bronchodilator Agents; D005938:Glucocorticoids; D003473:Neuromuscular Nondepolarizing Agents; D001279:Atracurium; D011239:Prednisolone; D013806:Theophylline
vernacular_title: Akute Rhabdomyolyse im Status asthmaticus.