title: Clear cell odontogenic carcinoma in the mandible: histochemical and immunohistochemical observations with a review of the literature.
abstract: A rare case of clear cell odontogenic carcinoma was investigated using histochemical and immunohistochemical methods. The tumor occurred in the anterior mandible of a 69-year-old Japanese man. Histologically, the tumor was composed mostly of large clear cells and squamous cells. Columnar-shaped cells with basophilic nuclei polarized away from the basement membrane were observed at the periphery of the tumor foci. The tumor cells had aggressively invaded muscle and perineural tissues. The tumor cells were positive for PAS staining. Immunohistochemically, tumor cells reacted positively to keratin, cytokeratin19, epithelial membrane antigen, and S-100 protein. The tumor was diagnosed as a clear cell odontogenic carcinoma. Its characteristics are discussed in term of its histopathological, histochemical and immunohistochemical features.
authors.affiliation: Department of Pathology, Tokyo Dental College, Chiba, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Muramatsu
authors.forename: S
authors.initials: S
authors.lastname: Hashimoto
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: M
authors.initials: M
authors.lastname: Shimono
authors.forename: H
authors.initials: H
authors.lastname: Noma
authors.forename: T
authors.initials: T
authors.lastname: Shigematsu
mesh_terms: D000368:Aged; D001485:Basement Membrane / Q000473:pathology; D002467:Cell Nucleus / Q000648:ultrastructure; D004396:Coloring Agents; D005152:Facial Muscles / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008297:Male; D008339:Mandibular Neoplasms / Q000473:pathology*; D008340:Mandibular Nerve / Q000473:pathology; D018396:Mucin-1 / Q000032:analysis; D009361:Neoplasm Invasiveness; D009808:Odontogenic Tumors / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis
chemical_list: D004396:Coloring Agents; D018396:Mucin-1; D009418:S100 Proteins; D007633:Keratins