title: Effects of systemic morphine on the activity of convergent neurons of spinal trigeminal nucleus oralis in the rat.
abstract: The spinal trigeminal nucleus oralis has been shown to relay nociceptive inputs mainly from the oral and perioral regions. In this study, we examined the effects of intravenous administration of morphine on C-fiber-evoked activities of spinal trigeminal nucleus oralis convergent neurons in halothane-anesthetized rats. Morphine depressed the C-fiber-evoked responses of spinal trigeminal nucleus oralis convergent neurons in a dose-related (3-12 mg/kg range) and naloxone-reversible fashion. The ED50 was 6.1 mg/kg, a dose similar to that found in the spinal horn. The observed strong depressive action of morphine on noxious-evoked activities of spinal trigeminal nucleus oralis neurons is consistent with our previous statement, based on electrophysiological studies, that this region plays an important role in the transmission of trigeminal nociceptive information. The effect of morphine on the spinal trigeminal nucleus oralis neurons is discussed in relation to its possible site and mechanism of action.
authors.affiliation: Laboratoire de Physiologie Oro-Faciale, Faculté de Chirurgie Dentaire, Clermont-Ferrand, France.
authors.forename: R
authors.initials: R
authors.lastname: Dallel
authors.forename: P
authors.initials: P
authors.lastname: Luccarini
authors.forename: J L
authors.initials: JL
authors.lastname: Molat
authors.forename: A
authors.initials: A
authors.lastname: Woda
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D007275:Injections, Intravenous; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009412:Nerve Fibers / Q000187:drug effects*; D010146:Pain / Q000517:prevention & control; D051381:Rats; D017207:Rats, Sprague-Dawley; D014279:Trigeminal Nucleus, Spinal / Q000187:drug effects*
chemical_list: D009020:Morphine