title: Treatment of rats with the peroxisome proliferator ciprofibrate results in increased liver NF-kappaB activity.
abstract: Nuclear factor kappaB (NF-kappaB) is an important stress-induced transcription factor in many cell types, including hepatocytes. Previous studies have shown that reactive oxygen species, including hydrogen peroxide, are potent activators of NF-kappaB. Peroxisome proliferators are a group of rodent chemical carcinogens that have been proposed to act by increasing reactive oxygen in the liver. These results led us to consider whether peroxisome proliferators would increase NF-kappaB activity in the liver. Here we demonstrate that rats fed diets containing the peroxisome proliferator ciprofibrate exhibit increased hepatic NF-kappaB DNA-binding activity. This observation suggests that NF-kappaB may contribute, in part, to peroxisome proliferator-mediated changes in the liver.
authors.affiliation: Graduate Center for Toxicology, University of Kentucky, College of Medicine, Lexington 40536-0084, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: L K
authors.initials: LK
authors.lastname: Leung
authors.forename: H P
authors.initials: HP
authors.lastname: Glauert
authors.forename: B T
authors.initials: BT
authors.lastname: Spear
mesh_terms: D000818:Animals; D001665:Binding Sites; D002995:Clofibric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D004247:DNA / Q000378:metabolism; D004586:Electrophoresis; D058607:Fibric Acids; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008830:Microbodies / Q000187:drug effects* / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism*; D051381:Rats
chemical_list: D058607:Fibric Acids; D000960:Hypolipidemic Agents; D016328:NF-kappa B; D002995:Clofibric Acid; D004247:DNA; C019304:ciprofibrate