The value of serum interleukin-6 measurement in the investigation of patients suspected of myocardial infarction.
Interleukin-6 (IL-6) is one of the cytokine mediators of the acute phase response. The value of IL-6 determination in the investigation of patients suspected of acute myocardial infarction and unstable angina is not fully established. In 26 patients being investigated for AMI and UA, IL-6, Creatine Kinase (CK) and Troponin T (TnT) were elevated with peak values at 12 hours (for IL-6 and CK) and at 0 and 24 hours (for TnT) following admission. CK values in AMI were significantly different from UA patients at 0, 6, 12, and 25 hours following admission, whereas, IL-6 values showed significant difference only at 24 hours. TnT showed a significant difference between the groups at 0 and 24 hours following admission. There was poor negative correlation between IL-6 and CK levels and percentage left ventricular ejection fraction. This study showed that, although IL-6 was elevated in AMI and UA patients, the spread of the data indicated that its measurement is of limited value in the diagnosis of AMI.
Zawawi
T H
TH
Department of Medicine, King Khalid National Guard Hospital, Jeddah, Kingdom of Saudi Arabia.
Alyafi
W A
WA
Hashim
I A
IA
Kholeif
M A
MA
Kholaif
M A
MA
Abdelaal
M A
MA
D000789:Angina, Unstable / Q000097:blood / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis*; D011446:Prospective Studies; D013318:Stroke Volume; D013997:Time Factors; D014336:Troponin / Q000097:blood; D020107:Troponin T; D016277:Ventricular Function, Left
D015415:Biomarkers; D015850:Interleukin-6; D014336:Troponin; D020107:Troponin T; D003402:Creatine Kinase