title: Methotrexate osteopathy, does it exist?
abstract: We describe 2 postmenopausal women with rheumatoid arthritis (RA). They developed fractures during their treatment with weekly low dose methotrexate (MTX). The adverse effect of longterm low dose regimens of MTX on bone metabolism has been described as "methotrexate osteopathy," an analogy of the syndrome known in pediatric oncology. MTX may be an additional risk factor for osteoporosis and fractures in RA. This therapy should be relatively contraindicated in patients with multiple risk factors for osteoporosis.
authors.affiliation: Department of Internal Medicine, K. U. Leuven, Pellenberg, Belgium.
authors.forename: K
authors.initials: K
authors.lastname: Maenaut
authors.forename: R
authors.initials: R
authors.lastname: Westhovens
authors.forename: J
authors.initials: J
authors.lastname: Dequeker
mesh_terms: D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000188:drug therapy; D001847:Bone Diseases / Q000139:chemically induced* / Q000150:complications; D004305:Dose-Response Relationship, Drug; D005260:Female; D015775:Fractures, Stress / Q000209:etiology; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D017698:Postmenopause; D011859:Radiography; D011877:Radionuclide Imaging; D013997:Time Factors
chemical_list: D018501:Antirheumatic Agents; D008727:Methotrexate