title: [Anti-inflammatory and analgesic actions of of long-chain phenyl substituted alpha-aminoketones].
abstract: The investigated phenyl substituted alpha-amino ketones have anti-inflammatory and analgesic activities as could be shown in animal models (rats and mice). The effectiveness depends on the length of the alkyl chain. After i.p. application the most active amino ketones are ten times more effective than acetyl salicylic acid, but the activity did not reach that of indomethacin. The effective analgesic dose is ten times lower than that for anti-inflammatory action. Including the results of the toxicity the analgesic efficiency of the amino ketones could be lead to substances with high analgesic activity. After oral administration only in high doses anti-inflammatory and analgesic effectivities were found. The structural analog keto group instead of the ester or amid group leads not to the expected increase in p.o. effectivity.
authors.affiliation: Institut für Pharmakologie und Toxikologie an der Medizinischen Fakultät, Universität Rostock, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Schulz
authors.forename: C
authors.initials: C
authors.lastname: Frahm
authors.forename: M
authors.initials: M
authors.lastname: Kobow
authors.forename: W D
authors.initials: WD
authors.lastname: Sprung
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D007659:Ketones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010147:Pain Measurement / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D007659:Ketones; D002351:Carrageenan
vernacular_title: Antiphlogistische und analgetische Wirkungen von längerkettigen phenylsubstituierten alpha-Aminoketonen.