title: Prospective randomized trial of carotid endarterectomy with primary closure and patch angioplasty with saphenous vein, jugular vein, and polytetrafluoroethylene: perioperative (30-day) results.
abstract: OBJECTIVE
  The early outcomes of carotid endarterectomy (CEA) with primary closure (PC) versus vein patch closure (saphenous vein [SVP] and jugular vein [JVP]) and polytetrafluoroethylene patch closure (PTFE-PC) were compared.
  
  
  METHODS
  Three hundred ninety-nine CEAs were randomized into the following groups: 135 PC, 134 PTFE-PC, and 130 vein patch closure (SVP alternating with JVP). Surviving patients underwent a carotid color duplex ultrasonographic scan 1 month after surgery. Demographic characteristics were similar in all groups.
  
  
  RESULTS
  The incidence of perioperative cerebrovascular accidents (CVAs) was 4.4% for PC, 0.8% for PTFE-PC, and 0% for vein patch closure (PC vs vein patch, p = 0.0165; PC vs all patching [vein and PTFE], p = 0.007). The perioperative CVA and reversible ischemic neurologic deficit (RIND) combined rates for all patching were superior to PC (1.5% vs 5.2%; p = 0.04). These combined rates were also superior for vein patch closure when compared with PC (0.8% vs 5.2%; p = 0.037). The mean diameter of the internal carotid artery was similar in patients who had perioperative neurologic deficits and those who did not. After 1 month of follow-up, 11.9% of the PC arteries were narrowed 50% or more in contrast to 2.3% for PTFE-PC, 3.1% for SVP, and 10.3% for JVP.
authors.affiliation: Department of Surgery, Robert C. Byrd Health Sciences Center of West Virginia University, Charleston Division, USA.
authors.forename: A F
authors.initials: AF
authors.lastname: AbuRahma
authors.forename: J H
authors.initials: JH
authors.lastname: Khan
authors.forename: P A
authors.initials: PA
authors.lastname: Robinson
authors.forename: S
authors.initials: S
authors.lastname: Saiedy
authors.forename: Y S
authors.initials: YS
authors.lastname: Short
authors.forename: J P
authors.initials: JP
authors.lastname: Boland
authors.forename: J F
authors.initials: JF
authors.lastname: White
authors.forename: Y
authors.initials: Y
authors.lastname: Conley
mesh_terms: D000368:Aged; D001807:Blood Vessel Prosthesis; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging; D016893:Carotid Stenosis / Q000000981:diagnostic imaging / Q000453:epidemiology; D002561:Cerebrovascular Disorders / Q000453:epidemiology*; D016894:Endarterectomy, Carotid / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007601:Jugular Veins / Q000637:transplantation*; D008297:Male; D011138:Polytetrafluoroethylene; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000453:epidemiology*; D011446:Prospective Studies; D012501:Saphenous Vein / Q000637:transplantation*; D013997:Time Factors; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D011138:Polytetrafluoroethylene