[Experimental study of possible treatment of Marburg hemorrhagic fever with desferal, ribavirin, and homologous interferon].
The paper presents data on the effects of the drugs desferal, ribavirin and homologous (guinea pig) interferon on the course of experimental Marburg fever. Neither ribavirin nor interferon were effective. A moderate response to desferal was noted. It is suggested that tumor necrosis factor may contribute to development of Marburg hemorrhagic fever.
Ignat'ev
G M
GM
Strel'tsova
M A
MA
Agafonov
A P
AP
Kashentseva
E A
EA
Prozorovskiĭ
N S
NS
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D000998:Antiviral Agents / Q000627:therapeutic use*; D003676:Deferoxamine / Q000627:therapeutic use*; D006168:Guinea Pigs; D007372:Interferons / Q000627:therapeutic use*; D008379:Marburg Virus Disease / Q000097:blood / Q000188:drug therapy* / Q000821:virology; D029024:Marburgvirus / Q000276:immunology; D012254:Ribavirin / Q000627:therapeutic use*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D014766:Viremia
D000914:Antibodies, Viral; D000998:Antiviral Agents; D014409:Tumor Necrosis Factor-alpha; D012254:Ribavirin; D007372:Interferons; D003676:Deferoxamine
Eksperimental'noe izuchenie vozmozhnosti lecheniia gemorragicheskoĭ likhoradki Marburg desferalom, ribavirinom i gomologichnym interferonom.