Mammalian aldehyde dehydrogenases: regulation of gene expression.
The mammalian aldehyde dehydrogenases (ALDH) are a family of functionally and structurally related enzymes encoded by multiple genes. Genes representing each major class of mammalian ALDHs, Class 1, 2 and 3, have been cloned and characterized. Functional analysis of the 5' flanking regions of these genes is just beginning, but such studies suggest roles for a diverse set of cis-elements and trans-acting factors in the tissue-specific and ligand-mediated expression of the ALDH genes.
Lindahl
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Department of Biochemistry and Molecular Biology, University of South Dakota School of Medicine, Vermillion 57069, USA.
D000444:Aldehyde Dehydrogenase / Q000145:classification / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D005091:Exons; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007438:Introns; D051379:Mice; D005810:Multigene Family; D051381:Rats
D004247:DNA; D000444:Aldehyde Dehydrogenase