title: [Immunologic effects of blood donation].
abstract: The effects of blood transfusion and blood donation on the immune system are still unclear. In a prospective study we investigated the effect of blood and blood component donation on several immunologic parameters. Lymphocyte subsets and cytokine levels were determined in 25 repeat whole-blood donors (RD), 25 plateletpheresis donors (PD), and 20 autologous blood donors (AD). First-time donors (FTD, n = 20) served as controls. Lymphocyte subsets and cytokines were determined using standard methods. Leukocytes, T-suppressor cells and natural killer (NK) cells were decreased in RD and PD when compared to FTD. Additionally, NK cells decreased with repeat donations in AD. No significant differences of cytokines in the different groups or during repeat autologous donations were observed.
authors.affiliation: Abteilung für Transfusionsmedizin, Universitätsklinik Göttingen, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Lange
authors.forename: J
authors.initials: J
authors.lastname: Riggert
authors.forename: A
authors.initials: A
authors.lastname: Humpe
authors.forename: J
authors.initials: J
authors.lastname: Dittmann
authors.forename: G
authors.initials: G
authors.lastname: Simson
authors.forename: M
authors.initials: M
authors.lastname: Köhler
mesh_terms: D000328:Adult; D000917:Antibody Formation / Q000276:immunology*; D016175:B-Lymphocyte Subsets / Q000276:immunology; D001782:Blood Donors; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007111:Immunity, Cellular / Q000276:immunology*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology
chemical_list: D016207:Cytokines
vernacular_title: Immunologische Auswirkungen der Blutspende.