The influence of selected general anesthetics on pharmacokinetic parameters of some antiarrhythmic drugs in rabbits. Part V. Verapamil.
The influence of general anesthesia with thiopental (10 mg/kg), ketamine (4 mg/kg) or propofol (10 mg/k) on the verapamil (0.2 mg/kg) pharmacokinetic parameters was studied in rabbits. It was established that during thiopental or ketamine anesthesia the levels of verapamil may be higher than therapeutic ones. The increase of area under drug level curves and the decrease of volume of distribution of verapamil during thiopental or propofol anesthesia were found.
Orszulak-Michalak
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Department of Pharmacodynamics, Medical University, Lódź, Poland.
D000704:Analysis of Variance; D000778:Anesthetics, Dissociative / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D001682:Biological Availability; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D007275:Injections, Intravenous; D007649:Ketamine / Q000494:pharmacology; D008297:Male; D015742:Propofol / Q000494:pharmacology; D011817:Rabbits; D013874:Thiopental / Q000494:pharmacology; D014700:Verapamil / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D000778:Anesthetics, Dissociative; D018686:Anesthetics, Intravenous; D002121:Calcium Channel Blockers; D007649:Ketamine; D014700:Verapamil; D013874:Thiopental; D015742:Propofol