Embryonic expression patterns of Xenopus syndecans.
Syndecans are a family of heparan sulfate proteoglycans implicated in cell-cell and cell-matrix interactions. To investigate the roles of syndecans in early development, we identified three syndecan family members in Xenopus laevis: Xsyn-1, Xsyn-2, and Xsyn-3. Xsyn-1 and Xsyn-2 are maternal mRNAs localized to the animal pole in blastulae, and are expressed in the ectoderm of gastrulae. In neurulae, Xsyn-1 is restricted to non-neural ectoderm and Xsyn-2 is restricted to neural ectoderm. In tailbud embryos, the three syndecans are expressed in adjacent, non-overlapping patterns. Xsyn-2 is expressed in the heart while Xsyn-1 is expressed in the underlying anterior endoderm. Xsyn-3 is expressed in the hindbrain, midbrain, and forebrain, while Xsyn-2 is expressed in the intervening regions. These results suggest that different members of the syndecan family have distinct developmental roles, perhaps acting as barriers to define tissue boundaries.
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Department of Cell Biology and Neuroanatomy, University of Minnesota, Minneapolis 55455, USA.
Yost
H J
HJ
D000595:Amino Acid Sequence; D000818:Animals; D015152:Blotting, Northern; D015139:Blotting, Southern; D018076:DNA, Complementary / Q000737:chemistry; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics*; D008969:Molecular Sequence Data; D011509:Proteoglycans / Q000737:chemistry / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D017468:Receptors, Fibroblast Growth Factor / Q000737:chemistry / Q000235:genetics*; D053668:Syndecan-1; D053669:Syndecan-2; D053670:Syndecan-3; D053667:Syndecans; D014981:Xenopus; D029867:Xenopus Proteins
D018076:DNA, Complementary; D008562:Membrane Glycoproteins; D011509:Proteoglycans; D012333:RNA, Messenger; D017468:Receptors, Fibroblast Growth Factor; C508244:SDC1 protein, Xenopus; C508316:SDC3 protein, Xenopus; D053668:Syndecan-1; D053670:Syndecan-3; D053667:Syndecans; D029867:Xenopus Proteins; C508248:sdc2 protein, Xenopus; D053669:Syndecan-2