Pathophysiologic substrate for ventricular tachycardia in coronary artery disease and non-ischemic heart disease.
Sustained uniform monomorphic ventricular tachycardia is usually due to abnormalities of conduction, including coronary artery disease and right ventricular dysplasia. These conduction abnormalities are due to non-uniform anisotropy which is characterized by fragmented electrograms. Less is known about the pathophysiologic substrate of sustained ventricular tachycardia in the absence of coronary artery disease or cardiomyopathy.
Josephson
M E
ME
Clinical Laboratories, Harvard-Thorndike Electrophysiology Institute, Boston, MA, USA.
Kirchhof
C
C
el Shalakany
A
A
Papageorgiou
P
P
Zimetbaum
P
P
D003327:Coronary Disease / Q000150:complications*; D006329:Heart Conduction System / Q000502:physiology; D006331:Heart Diseases / Q000150:complications*; D006801:Humans; D017180:Tachycardia, Ventricular / Q000209:etiology* / Q000503:physiopathology