Evidence of overload, dissolution and breakage of MMVF10 fibres in the RCC chronic inhalation study.
This paper describes (i) the evidence revealing the biological mechanisms underlying data from inhalation experiments at the Research and Consulting Company (RCC) (HESTERBERG et al. 1993); and (ii) the quantitative evaluation of the kinetic rates of these mechanisms using a mathematical model developed at the Institute of Occupational Medicine (IOM) (TRAN et al. 1994).
Tran
C L
CL
Institute of Occupational Medicine, Edinburgh, UK.
Jones
A D
AD
Donaldson
K
K
D000280:Administration, Inhalation; D000336:Aerosols / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008168:Lung / Q000473:pathology*; D008433:Mathematics; D019016:Mineral Fibers / Q000032:analysis*; D008954:Models, Biological; D051381:Rats; D013997:Time Factors
D000336:Aerosols; D019016:Mineral Fibers