Human cytomegalovirus infection inhibits cell cycle progression at multiple points, including the transition from G1 to S.
Human cytomegalovirus inhibits the growth of human foreskin fibroblast cells by 12 h after infection. Analysis of the cellular DNA content of infected cells by flow cytometry demonstrated that cytomegalovirus does not arrest cell cycle progression at a single point. At least two blockages occur, one of which is in the G1 phase of the cell cycle. The G1 arrest introduced by cytomegalovirus infection blocks S-phase entry after serum stimulation.
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Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, New Jersey 08544-1014, USA.
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D002453:Cell Cycle; D002455:Cell Division; D002460:Cell Line; D003587:Cytomegalovirus / Q000378:metabolism*; D016193:G1 Phase; D006801:Humans; D016196:S Phase; D015398:Signal Transduction