title: Malignant fibrous histiocytoma of the lung. Report of four cases and review of the literature.
abstract: BACKGROUND
  Primary malignant fibrous histiocytoma (MFH) of the lung is a rare clinical entity. Only 23 reports of 49 cases have been reported in the literature. Surgery was the primary mode of therapy, with high rates of local and distant recurrence reported. The role of radiation therapy and chemotherapy has never been clearly defined.
  
  
  METHODS
  The records of the Mayo Clinic in Scottsdale and Rochester from 1970 to 1990 were reviewed for cases of primary pulmonary MFH. A review of the literature was also undertaken.
  
  
  RESULTS
  Four cases from the Mayo records and 49 cases from a review of the literature were identified. Eight patients were alive at 5 years from diagnosis; all had been treated with surgery as the primary modality. No definite relationship between histologic subtype of MFH and survival could be identified and no definite role of radiation therapy or chemotherapy could be defined.
  
  
  CONCLUSIONS
  MFH of the lung should be treated by surgical resection if technically feasible. The role of adjuvant therapy remains undefined.
authors.affiliation: Mayo Clinic Scottsdale, Arizona 85259, USA.
authors.forename: M Y
authors.initials: MY
authors.lastname: Halyard
authors.forename: J K
authors.initials: JK
authors.lastname: Camoriano
authors.forename: J A
authors.initials: JA
authors.lastname: Culligan
authors.forename: L H
authors.initials: LH
authors.lastname: Weiland
authors.forename: M S
authors.initials: MS
authors.lastname: Allen
authors.forename: J R
authors.initials: JR
authors.lastname: Pluth
authors.forename: P C
authors.initials: PC
authors.lastname: Pairolero
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011859:Radiography