title: Ketanserin in the treatment of protamine-induced pulmonary hypertension.
abstract: The reversal of heparin by protamine may cause severe hemodynamic deterioration, characterized by systemic hypotension, pulmonary hypertension, and bronchoconstriction. A case report is presented concerning the administration of ketanserin in the treatment of pulmonary vasoconstriction and right ventricular failure following the infusion of protamine in a patient undergoing coronary artery bypass surgery and mitral valve replacement. The potential role of serotonin in the development of this serious complication is discussed.
authors.affiliation: Department of Cardiothoracic Anesthesiology and Intensive Care Hospital De Weezenlanden, Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: van der Starre
authors.forename: C
authors.initials: C
authors.lastname: Solinas
mesh_terms: D000368:Aged; D001026:Coronary Artery Bypass; D006350:Heart Valve Prosthesis; D006494:Heparin Antagonists / Q000009:adverse effects*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced* / Q000188:drug therapy; D007650:Ketanserin / Q000627:therapeutic use*; D008297:Male; D008944:Mitral Valve Insufficiency / Q000601:surgery; D011479:Protamines / Q000009:adverse effects*; D012702:Serotonin Antagonists / Q000627:therapeutic use*
chemical_list: D006494:Heparin Antagonists; D011479:Protamines; D012702:Serotonin Antagonists; D007650:Ketanserin