title: A rat model of infection by Salmonella typhimurium or Salm. enteritidis.
abstract: Salmonellosis in the rat has many similarities with the disease in humans, with the ileum thought to be the main site of colonization/invasion in both species. Thus, the rat may be a useful way to study the mechanism of infection by these pathogenic bacteria. A series of infection trials carried out with Hooded Lister rats showed that a salmonella infection persisted for an extended period of time and that salmonellae bind to the small intestinal epithelium as early as 4 h after intragastric intubation. Reinfection from the large intestine may not therefore initially play a significant role in the salmonella infection process. The rat model may therefore provide a means to test in vivo interventionist strategies, designed to block binding of the pathogens in the gastrointestinal tract.
authors.affiliation: Division of Nutritional Sciences, Rowett Research Institute, Bucksburn, Aberdeen, UK. pjn@rri.sari.ac.uk
authors.forename: P J
authors.initials: PJ
authors.lastname: Naughton
authors.forename: G
authors.initials: G
authors.lastname: Grant
authors.forename: R J
authors.initials: RJ
authors.lastname: Spencer
authors.forename: S
authors.initials: S
authors.lastname: Bardocz
authors.forename: A
authors.initials: A
authors.lastname: Pusztai
mesh_terms: D000818:Animals; D001431:Bacteriological Techniques; D004195:Disease Models, Animal; D007082:Ileum / Q000382:microbiology; D007583:Jejunum / Q000382:microbiology; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D012481:Salmonella Infections, Animal; D012477:Salmonella enteritidis; D012486:Salmonella typhimurium; D013047:Specific Pathogen-Free Organisms