[99mTc]tricine: a useful precursor complex for the radiolabeling of hydrazinonicotinate protein conjugates.
The stannous reduction of [99mTc]pertechnetate in the presence of tricine results in the formation of the new labeling precursor complex [[99m-Tc]tricine. This complex has improved efficacy for the 99mTc labeling of hydrazinonicotinate-modified IgG compared to [99mTc]glucoheptonate. FAB mass spectral analysis of the product formed by the reaction of [TcOCl4](-1) with tricine indicates the formation of [TcO(tricine x 2H)2](-1).
Larsen
S K
SK
Johnson Matthey Pharmaceutical, West Chester, Pennsylvania 19380, USA.
Solomon
H F
HF
Caldwell
G
G
Abrams
M J
MJ
D003432:Cross-Linking Reagents; D005998:Glycine / Q000031:analogs & derivatives* / Q000737:chemistry; D006801:Humans; D007074:Immunoglobulin G / Q000737:chemistry; D009536:Niacinamide / Q000031:analogs & derivatives; D015609:Organotechnetium Compounds / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013388:Succinimides; D013400:Sugar Acids / Q000737:chemistry
D003432:Cross-Linking Reagents; D007074:Immunoglobulin G; D015609:Organotechnetium Compounds; D011506:Proteins; D013388:Succinimides; D013400:Sugar Acids; C073102:succinimidyl 6-hydrazinonicotinate; D009536:Niacinamide; C100014:technetium Tc 99m gluceptate; D005998:Glycine; C100184:tricine