title: [Thrombosis on the mitral valve prosthesis and disseminated cancer: treatment by fibrinolysis].
abstract: The authors report the case of a 63-year-old woman with occlusive thrombosis of a mitral valve prosthesis and cardiogenic shock successfully treated by systemic thrombolytic therapy. This treatment was given despite metastatic hepatic and bone breast cancer. This, and other recently reported cases, argues in favour of widening the indication of thrombolysis as treatment of first intention in cases of obstruction of atrioventricular valve prostheses. Nevertheless, the relative safety of surgical treatment and the risk of systemic thromboembolism of thrombolysis, incites caution and reservation of medical therapy for carefully selected patients.
authors.affiliation: Hôpital cardiovasculaire et pneumotegique, Lyon.
authors.forename: P
authors.initials: P
authors.lastname: Chevalier
authors.forename: E
authors.initials: E
authors.lastname: Bonnefoy
authors.forename: G
authors.initials: G
authors.lastname: Kirkorian
authors.forename: C
authors.initials: C
authors.lastname: Richalet
authors.forename: N
authors.initials: N
authors.lastname: Bourret
authors.forename: D
authors.initials: D
authors.lastname: Bouchayer
authors.forename: P
authors.initials: P
authors.lastname: Touboul
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve; D009362:Neoplasm Metastasis; D012770:Shock, Cardiogenic / Q000209:etiology; D013300:Streptokinase / Q000627:therapeutic use*; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D013300:Streptokinase
vernacular_title: Thrombose de prothèse valvulaire mitrale et cancer disséminé: traitement par fibrinolyse.