Fluctuating asymmetry and disorders of developmental origin.
Environmental and/or genetic stresses may cause a breakdown in developmental homeostasis, resulting in increased bilateral asymmetry of morphological traits. The degree of these deviations (termed "fluctuating asymmetry") is thought to correlate with the severity of the stress. If these stresses also play a role in the appearance of developmental disorders, then increased morphological asymmetry may serve as a risk marker for disorders of developmental origin. This would be possible if 1) the environmental stress that caused a breakdown in developmental stability also contributed to the appearance of the disorder, and/or 2) the genetic predisposition (liability) to the disorder and increased susceptibility to fluctuating asymmetry have a common cause. Although a number of authors have reported associations between increased fluctuating asymmetry and disorders of presumed developmental origin, the usefulness of fluctuating asymmetry as a risk marker has not been established. One obstacle to this assessment is the lack of odds ratios reported by previous authors.
Naugler
C T
CT
Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.
Ludman
M D
MD
D002648:Child; D002658:Developmental Disabilities / Q000235:genetics*; D004777:Environment; D005819:Genetic Markers; D005838:Genotype; D006706:Homeostasis; D006801:Humans; D012307:Risk Factors
D005819:Genetic Markers