Short-term canine implantation of a glucose monitoring-telemetry device.
In this study we report the development and short-term in vivo evaluation of an integrated implantable device consisting of an amperometric glucose biosensor, a miniature potentiostat, a FM signal transmitter, and power supply. The device (dimensions: 5.0 x 7.0 x 1.5 cm) was implanted under the skin of medium-size anaesthetized dog. The experimental set-up included several methods for data collection: analog recording via wired X-T chart recorders; data collection by wearable microprocessor--data logger, and remote data collection via antenna and receiver linked to a computer-based data acquisition system. The device (sensor) performance was evaluated in vitro prior to implantation, using different model solutions simulating the physiological environment. A linear response to glucose concentration was obtained up to 25 mM glucose, with a sensitivity of 0.5 microA/mM. The results of short-term subcutaneous implantation of the integrated device reveal adequate monitoring of an artificially-induced glycaemia. The delay-time was 3-7 minutes. These tests demonstrate the feasibility of data transmission by the telemetry system through the skin of a medium-sized dog and allow the commencement of chronic in vivo experimentation.
Atanasov
P
P
Department of Chemical and Nuclear Engineering, School of Engineering, University of New Mexico, Albuquerque 87131, USA.
Yang
S
S
Salehi
C
C
Ghindilis
A L
AL
Wilkins
E
E
D000818:Animals; D015374:Biosensing Techniques; D001774:Blood Chemical Analysis / Q000295:instrumentation*; D001786:Blood Glucose / Q000378:metabolism*; D002138:Calibration; D004285:Dogs; D011211:Electric Power Supplies; D004867:Equipment Design; D005069:Evaluation Studies as Topic; D019736:Prostheses and Implants; D013686:Telemetry
D001786:Blood Glucose