title: Motor cortical muscimol injection disrupts forelimb movement in freely moving monkeys.
abstract: To investigate how GABAA inhibition in the motor cortex is involved in motor control in freely moving infant macaque monkeys, muscimol, a GABAA agonist, was injected into the hand motor area and changes in movement parameters of visual reaching during apple pickup tests or a delayed response task were examined. After the injection (30 micrograms microliters-1) the monkeys tended to use the contralateral hand, and the ipsilateral hand showed a posture of dropped wrist and fingers, as if the radial nerve were paralysed. Movement time and/or reaction time of the ipsilateral hand was prolonged. Motorcortical GABAA inhibition is important for initiation of smooth flexion and/or extension movement of the hand and fingers.
authors.affiliation: Department of Behavioral and Brain Sciences, Kyoto University, Aichi, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kubota
mesh_terms: D000818:Animals; D004292:Dominance, Cerebral; D005552:Forelimb / Q000294:innervation / Q000502:physiology*; D018755:GABA Agonists / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity*; D006225:Hand / Q000502:physiology; D007267:Injections; D008251:Macaca / Q000502:physiology*; D008253:Macaca mulatta / Q000502:physiology; D008297:Male; D009044:Motor Cortex / Q000187:drug effects* / Q000502:physiology; D009068:Movement / Q000187:drug effects* / Q000502:physiology; D009118:Muscimol / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity*; D011597:Psychomotor Performance / Q000187:drug effects* / Q000502:physiology; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology
chemical_list: D018755:GABA Agonists; D011963:Receptors, GABA-A; D009118:Muscimol