title: Synthesis and activity of pseudotripeptide inhibitors of HIV-1 protease containing D(-)-O-(benzyl)tartaric acid.
abstract: Four HIV-1 protease inhibitors containing [(S,S)-O-(benzyl) tartaric acid]-Pro as a transition-state mimic were prepared and evaluated by a spectrophotometric assay. Two pseudotripeptide derivatives showed weak inhibitory activity similar to acetylpepstatin.
authors.affiliation: Department of Pharmaceutical Science, University of Ferrara, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Marastoni
authors.forename: G
authors.initials: G
authors.lastname: Fantin
authors.forename: F
authors.initials: F
authors.lastname: Bortolotti
authors.forename: R
authors.initials: R
authors.lastname: Tomatis
mesh_terms: D000596:Amino Acids / Q000032:analysis; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D015497:HIV-1 / Q000201:enzymology*; D009682:Magnetic Resonance Spectroscopy; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013644:Tartrates / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000596:Amino Acids; D017320:HIV Protease Inhibitors; D009842:Oligopeptides; D013644:Tartrates; C073513:KNI 102