Lack of association between alpha 1-antichymotrypsin polymorphism, Alzheimer's disease, and allele epsilon 4 of apolipoprotein E.
We investigated the possibility that a polymorphism of alpha 1-antichymotrypsin modifies the risk for Alzheimer's disease (AD). Testing 147 AD patients and 74 controls, we did not find evidence of an association between alpha 1-antichymotrypsin polymorphism and AD and also failed to detect a modifying effect of this polymorphism in patients carrying at least one epsilon 4 allele of apolipoprotein E.
Müller
U
U
Institut für Humangenetik, Justus-Liebig-Universität, Giessen, Germany.
Bödeker
R H
RH
Gerundt
I
I
Kurz
A
A
D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D000514:alpha 1-Antichymotrypsin / Q000235:genetics*
D001057:Apolipoproteins E; D000514:alpha 1-Antichymotrypsin