[Cathepsin B-like substance in the monitoring of chemically induced primary cholangiocarcinoma in swine].
Activity of beta-glucuronidase (GL), placentar izoenzyme of alkaline phosphatase (PLAP), cathepsin B (CB) and concentrations of carcinoembryonic antigen (CEA) were determined in serums and bile of pigs with experimental cholangiocarcinoma and in control animals. No differences in serum GL, PLAP, CB activities or CEA were observed. The same was found in bile for GL, PLAP and CEA. However, in bile the situation was different for CB. In all the tumour bearing animals we were able to demonstrate in the course of tumour development a stricking progression in CB activity. Very impressive was namely an elevation of CB alkaline-stable form, generated (according also to the chromatographic studies of the bile) from primary cholangiocarcinoma tissue.
Dufek
V
V
I. interní klinika, 1. LF UK Praha.
Petrtýl
J
J
Klener
P
P
D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D001646:Bile / Q000737:chemistry; D001650:Bile Duct Neoplasms / Q000139:chemically induced / Q000175:diagnosis*; D001653:Bile Ducts, Intrahepatic; D014408:Biomarkers, Tumor / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002401:Cathepsin B / Q000032:analysis*; D018281:Cholangiocarcinoma / Q000139:chemically induced / Q000175:diagnosis*; D005966:Glucuronidase / Q000032:analysis; D007527:Isoenzymes / Q000032:analysis; D013552:Swine
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D007527:Isoenzymes; D000469:Alkaline Phosphatase; D005966:Glucuronidase; D002401:Cathepsin B
Prínos katepsinu B-like v monitorování chemicky indukovaného primárního cholangiokarcinomu veprů.