Inhibition of neuronal activity in rat hippocampal slices by Aconitum alkaloids.
The structurally related Aconitum alkaloids aconitine, lappaconitine, and 6-benzoylheteratisine inhibited the orthodromic and antidromic population spike in hippocampal CA1 area in a frequency-dependent manner. Aconitine (1 microM) completely suppressed epileptiform activity induced by omission of Mg2+ as well as normal neuronal activity, whereas lappaconitine (10 microM) and 6-benzoylheteratisine (10 microM) diminished epileptiform activity by sparing normal neuronal activity.
Ameri
A
A
Department of Pharmacy and Pharmacology of Natural Compounds, University of Ulm, Germany.
Gleitz
J
J
Peters
T
T
D000157:Aconitine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000200:Action Potentials / Q000187:drug effects; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D004558:Electric Stimulation; D004594:Electrophysiology; D004827:Epilepsy / Q000503:physiopathology; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*; D066298:In Vitro Techniques; D008274:Magnesium / Q000378:metabolism; D009433:Neural Inhibition; D009474:Neurons / Q000187:drug effects* / Q000502:physiology*; D051381:Rats
D000470:Alkaloids; C104702:6-benzoylheteratisine; D008274:Magnesium; D000157:Aconitine; C022150:lappaconitine