Long-term changes of markers of alcoholism after orthotopic liver transplantation (OLT).
Both physical rehabilitation and the course of the alcoholism improve after orthotopic liver transplantation (OLT) in patients with end-stage alcoholic liver cirrhosis. In the present study including 17 alcoholics and 14 nonalcoholics, after OLT, three of the alcoholic patients resumed their pre-OLT alcohol drinking habits, 4 consumed alcohol occasionally, 10 remained abstinent over the observation period of 13 to 36 months. The laboratory parameters before OLT did not discriminate alcoholics from nonalcoholic patients. Furthermore, the blood levels of two so-called alcogens (harman and norharman) were determined to investigate whether they discriminate between the two groups. Alcogens are natural compounds that are presumed to induce alcohol abuse in predisposed individuals. Both alcogens measured were elevated in plasma from nonalcoholics and alcoholics before OLT, suggesting a disturbance in inactivation in end-stage liver disease. Following OLT, the alcogens normalized but in the alcoholics this process was slower with respect to harman. The present exploratory study suggests that the normalized metabolic capacity of the liver after OLT causes a normalization of the levels of alcogens, for which harman and norharman are representative. These changes could contribute to the observed benefit to the outcome in alcoholics with respect to the alcohol dependence.
Rommelspacher
H
H
Department of Neuropsychopharmacology, Free University, Berlin, Germany.
Wiest
M
M
Neuhaus
R
R
Platzgummer
W
W
Schmidt
L G
LG
Neuhaus
P
P
D000328:Adult; D000437:Alcoholism / Q000534:rehabilitation; D000704:Analysis of Variance; D002243:Carbolines / Q000097:blood; D006247:Harmine / Q000031:analogs & derivatives / Q000097:blood; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000523:psychology / Q000601:surgery*; D008111:Liver Function Tests; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009498:Neurotoxins / Q000097:blood; D013997:Time Factors
D002243:Carbolines; D009498:Neurotoxins; D006247:Harmine; C005010:harman; C010262:norharman