title: The utility of non-beta-lactam antimicrobial MICs as markers to distinguish oxacillin-resistant from oxacillin-susceptible strains of Staphylococcus epidermidis.
abstract: Among 6,068 strains of Staphylococcus epidermidis, 75.5% were oxacillin-resistant. Oxacillin-susceptible strains were more frequently susceptible to erythromycin, clindamycin, ciprofloxacin, trimethoprim/sulfamethoxazole, gentamicin, and tetracycline than oxacillin-resistant strains. With the exception of erythromycin, non-beta-lactam MICs were less discriminatory for identifying oxacillin-resistant strains with oxacillin MICs < or = 2 micrograms/ml than for those with oxacillin MICs > or = 4 micrograms/ml.
authors.affiliation: Department of Internal Medicine, Ohio State University Medical Center, Columbus, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Fass
authors.forename: J
authors.initials: J
authors.lastname: Barnishan
authors.forename: L W
authors.initials: LW
authors.lastname: Ayers
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015415:Biomarkers; D002939:Ciprofloxacin / Q000494:pharmacology; D002981:Clindamycin / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000494:pharmacology; D005839:Gentamicins / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010068:Oxacillin / Q000494:pharmacology*; D010406:Penicillins / Q000494:pharmacology*; D013212:Staphylococcus epidermidis / Q000187:drug effects*; D013752:Tetracycline / Q000494:pharmacology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D015415:Biomarkers; D005839:Gentamicins; D010406:Penicillins; D002981:Clindamycin; D002939:Ciprofloxacin; D004917:Erythromycin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D013752:Tetracycline; D010068:Oxacillin