Molecular cloning of a novel receptor (CMKLR1) with homology to the chemotactic factor receptors.
We report the cloning of a novel human gene, CMKLR1, which encodes a protein that has notable sequence and structural homology to the seven transmembrane G-protein linked chemokine receptors. This gene has 55% nucleotide sequence homology to the IL-8 type 1 receptor and 53% to the N-formyl peptide related receptor 1 genes. The mRNA of this receptors is expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow, and fetal liver. Using fluorescence in situ hybridization the gene encoding CMLKR1 (chemokine-like receptor 1) was localized to human chromosome 12q24.1.
Gantz
I
I
Department of Surgery, University of Michigan Medical Center, Ann Arbor 48109-0682, USA.
Konda
Y
Y
Yang
Y K
YK
Miller
D E
DE
Dierick
H A
HA
Yamada
T
T
D000595:Amino Acid Sequence; D015703:Antigens, CD / Q000737:chemistry / Q000235:genetics; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D003001:Cloning, Molecular; D019204:GTP-Binding Proteins / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D008969:Molecular Sequence Data; D009928:Organ Specificity; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine / Q000737:chemistry / Q000235:genetics*; D044042:Receptors, Formyl Peptide; D011971:Receptors, Immunologic / Q000737:chemistry / Q000235:genetics; D018123:Receptors, Interleukin / Q000737:chemistry / Q000235:genetics; D023062:Receptors, Interleukin-8A; D018000:Receptors, Peptide / Q000737:chemistry / Q000235:genetics; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid
D015703:Antigens, CD; C102741:CMKLR1 protein, human; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine; D044042:Receptors, Formyl Peptide; D011971:Receptors, Immunologic; D018123:Receptors, Interleukin; D023062:Receptors, Interleukin-8A; D018000:Receptors, Peptide; D019204:GTP-Binding Proteins