The carcinogenicity of diethylstilbestrol: structural evidence for a non-genotoxic mechanism.
An analysis of the structure of diethylstilbestrol (DES) indicates that neither DES nor any of its metabolites are potential mutagens. Moreover, the present analyses suggest (a) that the observed carcinogenic spectrum of DES reflects the activity of metabolic intermediates and (b) that the carcinogenicity of DES in mice is due to the presence of a 6 A geometric descriptor that appears to be related to an estrogen receptor.
Cunningham
A
A
Department of Environmental and Occupational Health, University of Pittsburgh, PA 15238, USA.
Klopman
G
G
Rosenkranz
H S
HS
D000818:Animals; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000737:chemistry* / Q000633:toxicity*; D004249:DNA Damage; D004054:Diethylstilbestrol / Q000737:chemistry* / Q000633:toxicity*; D051379:Mice; D008956:Models, Chemical; D009152:Mutagenicity Tests; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects; D013329:Structure-Activity Relationship
D002273:Carcinogens; D004054:Diethylstilbestrol