[The effect of lithium oxybutyrate on aggressive animal behavior].
The aim of the study was to examine the aggressive behavior of rats after lithium hydroxybutyrate injections (10 mg/kg once a day, at 9 a.m or 7 p.m., for a week). It was found that the drug did not affect the aggressive behavior of isolated rats towards mice placed to them. However, in the evening the drug inhibited aggressive manifestations (attacks, bites) in rats with raphe midbrain lesions. The 5-hydroxytryptophan (20 mg/kg, intraperitoneally, once) augmented the antiaggressive properties of lithium hydroxybutyrate in the evening but weakened them in the morning.
Zamoshchina
T A
TA
Saratikov
A S
AS
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000374:Aggression / Q000187:drug effects*; D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects; D004567:Electrodes, Implanted; D006885:Hydroxybutyrates / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009942:Organometallic Compounds / Q000494:pharmacology*; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011903:Raphe Nuclei / Q000502:physiology / Q000601:surgery; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D012934:Social Isolation; D013997:Time Factors
D006885:Hydroxybutyrates; D009942:Organometallic Compounds; D011619:Psychotropic Drugs; C022826:lithium hydroxybutyrate; D006916:5-Hydroxytryptophan
Vliianie litiia oksibutirata na agressivnoe povedenie zhivotnykh.