Synthesis and anxiolytic activity of N-substituted cyclic imides N-[4-[(4-aryl)-1-piperazinyl]alkyl]-5,7-dioxabicyclo[2.2.2]octane-2, 3-dicarboximide.
The preparation of N-substituted cyclic imides N-[4-[(4-aryl)-1-piperazinyl]alkyl]-5,7-dioxabicyclo[2.2.2]octane- 2, 3-dicarboximides by condensation of N-(3-chloropropyl)- or N-(4-chlorobutyl)imides with appropriate amine has been described. One of compounds was tested in the Vogel's test and displayed an expected activity on CNS.
Zawadowski
T
T
Department of Medical Chemistry, School of Medicine, Warsaw, Poland.
Kossakowski
J
J
Rump
S
S
Jakowicz
I
I
Płaźnik
A
A
D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D002065:Buspirone / Q000494:pharmacology; D007094:Imides / Q000138:chemical synthesis; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000378:metabolism
D014151:Anti-Anxiety Agents; D007094:Imides; D011985:Receptors, Serotonin; D002065:Buspirone