title: Quasispecies in wild-type tula hantavirus populations.
abstract: Tula virus (TUL) is a recently detected hantavirus carried by European common voles. Reverse transcriptase PCR cloning was used to study TUL S segment/N protein quasispecies. Both the distribution and character of mutations observed in three mutant spectra indicated limited selection at the protein level. At least 8% of the mutations were neutral or well tolerated; fixation of such mutations may play a role in TUL evolution in its natural host.
authors.affiliation: Haartman Institute, Department of Virology, University of Helsinki, Finland. Alexander.Plyusnin@helsinki.fi
authors.forename: A
authors.initials: A
authors.lastname: Plyusnin
authors.forename: Y
authors.initials: Y
authors.lastname: Cheng
authors.forename: H
authors.initials: H
authors.lastname: Lehväslaiho
authors.forename: A
authors.initials: A
authors.lastname: Vaheri
mesh_terms: D000818:Animals; D003411:Arvicolinae / Q000821:virology; D019143:Evolution, Molecular; D006476:Orthohantavirus / Q000235:genetics*; D016296:Mutagenesis; D019251:Nucleocapsid / Q000235:genetics*; D012367:RNA, Viral / Q000032:analysis*
chemical_list: D012367:RNA, Viral