Intravitreal tolerance of a new perfluorocarbon vitreous replacement, Multifluor APF-144.
OBJECTIVE
To evaluate the intravitreal tolerance of a new perfluorocarbon vitreous replacement, Multifluor APF-144 (perfluorotetramethylcyclohexane).


METHODS
Ten New Zealand albino rabbits (one eye from each) underwent vitrectomy. The vitreous was replaced in five eyes with Multifluor APF-144 and in five eyes with saline (control group).


METHODS
Appearance on indirect ophthalmoscopy, electroretinography recordings before and 2, 4 and 8 weeks after vitrectomy, findings on electron and light microscopy at 8 weeks.


RESULTS
Endophthalmitis did not develop in any of the eyes. There was no significant change in electroretinography values for the experimental eyes after vitrectomy. No evidence of retinal toxicity was found on light or electron microscopic examination.


CONCLUSIONS
Multifluor APF-144 shows promise as a short-term postoperative retinal tamponading agent.
Peyman
G A
GA
LSU Eye Center, Louisiana State University Medical, Center School of Medicine, New Orleans 70112-2234, USA.
Soheilian
M
M
Luo
Q
Q
Moshfeghi
D
D
Schweighardt
F K
FK
D000818:Animals; D004596:Electroretinography; D005260:Female; D006845:Hydrocarbons, Fluorinated / Q000633:toxicity*; D008297:Male; D008854:Microscopy, Electron; D011817:Rabbits; D012160:Retina / Q000502:physiology* / Q000648:ultrastructure; D014821:Vitrectomy; D014822:Vitreous Body / Q000187:drug effects*; D005466:Fluorocarbons
D006845:Hydrocarbons, Fluorinated; C105683:perfluorotetramethylcyclohexane; D005466:Fluorocarbons