[A reversible functional disorder of the escape reaction as a model for studying the effect of tranquilizers].
A model of reversible functional disorders of the escape response (ER) for studying the effect of tranquilizers is proposed. The model is based on the unexpected action of electric current used regardless of the specific relation (stimulus-response effect). This results in enhanced emotional stress, reduces ER, and increases intersignal responses. The model proposed has less in common with the conflict situation because no interference of the opposite motivations is suggested, namely, the formation and disturbance of ER is based on the same unconditioned stimulus and test performance does not suggest punishment with electric current. We found that hydazepam (20 mg/kg) prevents and phenazepam (0.1 mg/kg) reduces the ER disorders.
Inozemtsev
A N
AN
Bakieva
S B
SB
Voronina
T A
TA
Tushmalova
N A
NA
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004924:Escape Reaction / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051381:Rats; D018709:Statistics, Nonparametric; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam; C077010:gidazepam
Obratimoe funktsional'noe narushenie reaktsii izbeganiia kak model' dlia izucheniia vliianiia trankvilizatorov.