Mechanism of exercise-induced augmentation of lymphokine activated killer (LAK) cell activity in the horse.
Intense exercise affects various parameters of the immune system. The overall effect of exercise on immune function is dependent upon the physical condition of the subject, the intensity and duration of the exercise period, and the immune parameter assessed. Unconditioned horses subjected to a single bout of intensive exercise exhibit multiple alterations in immune function, including an augmentation of lymphokine activated killer (LAK) cell function. This increase in LAK cell activity is not due to an increase in circulating LAK precursors. While peripheral blood mononuclear cells from exercising horses exhibit greater responsiveness to IL-2, this is not due to an increase in IL-2 receptor expression. LAK cell generation in vitro is augmented by those catecholamines and neuropeptides which are produced during exercise, suggesting a direct effect of these compounds on LAK cell generation at a step post IL-2 receptor binding.
Horohov
D W
DW
Department of Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803, USA. horohov@vt8200.vetmed.lsu.edu
Keadle
T L
TL
Pourciau
S S
SS
Littlefield-Chabaud
M A
MA
Kamerling
S G
SG
Keowen
M L
ML
French
D D
DD
Melrose
P A
PA
D000818:Animals; D002395:Catecholamines / Q000494:pharmacology; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D006736:Horses; D007376:Interleukin-2 / Q000494:pharmacology; D015979:Killer Cells, Lymphokine-Activated / Q000187:drug effects / Q000276:immunology* / Q000502:physiology*; D008213:Lymphocyte Activation / Q000187:drug effects / Q000502:physiology*; D008297:Male; D010805:Physical Conditioning, Animal; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis
D002395:Catecholamines; D007376:Interleukin-2; D015375:Receptors, Interleukin-2