NSAIDs and the gastrointestinal mucosa.
In the United States, these double-edged drugs cause as many as 20,000 deaths a year. To blunt their harmful effects, two promising strategies are being pursued: concurrent administration of prostaglandin analogues to support gastric homeostasis, and the development, or identification among existing NSAIDs, of an agent that targets inflammatory prostaglandins while sparing the homeostatic ones.
Wolfe
M M
MM
Boston University School of Medicine, USA.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D011453:Prostaglandins / Q000096:biosynthesis / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006635:Histamine H2 Antagonists; D011453:Prostaglandins