In vitro activity of quinolones and other antimicrobial agents against anaerobic bacteria.
The in vitro activities of ciprofloxacin, ofloxacin, sparfloxacin, and DU-6859a against peptostreptococci, Clostridium perfringens, Clostridium difficile, Bacteroides fragilis, Porphyromonas, Prevotella, and Fusobacterium were determined by an agar dilution method. These activities were compared with those of piperacillin/tazobactam, cefoxitin, imipenem, clindamycin, and metronidazole. Imipenem, metronidazole, and DU-6859a were the most active antimicrobial agents that were tested. The in vitro activity of DU-6859a was superior to those of ciprofloxacin, lomefloxacin, ofloxacin, and sparfloxacin.
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Department of Immunology, Microbiology, Pathology, and Infectious Diseases, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden.
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects* / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy; D004352:Drug Resistance, Microbial; D024841:Fluoroquinolones; D006801:Humans; D015378:Imipenem / Q000494:pharmacology; D066298:In Vitro Techniques; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000494:pharmacology
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D008795:Metronidazole; D015378:Imipenem; C076246:sitafloxacin