[Efficacy of pilocarpine and timolol maleate combination in therapy of glaucoma].
The authors assessed the effects of a single instillation and prolonged use of pilocarpine, thymolol maleate, fotyl, and fotyl-forte on the ophthalmic tone and some ocular functions in 118 patients (202 eyes) with glaucoma. The duration of pilocarpine effect is 6-8 h, that of thymolol maleate, fotyl, and fotyl-forte more than 24 h. The most expressed reduction of intraocular pressure was observed after fotyl and fotyl-forte (32-40% of initial level). Moreover, these agents showed the highest hypotensive activity upon prolonged (up to 6 months) use. Intraocular pressure normalized in about 70% patients. The hypotensive effect of fotyl-forte is somewhat higher than that of fotyl, but patients complain of pain after instillation of fotyl-forte 2-3 times more frequently than after fotyl.
Egorov
E A
EA
Department of eye diseases of medical faculty of Russian State Medical University, Moscow
Tsibaneva
E V
EV
Egorov
A E
AE
D000287:Administration, Topical; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010277:Parasympathomimetics / Q000008:administration & dosage*; D010862:Pilocarpine / Q000008:administration & dosage*; D013999:Timolol / Q000008:administration & dosage*
D000319:Adrenergic beta-Antagonists; D010277:Parasympathomimetics; D010862:Pilocarpine; D013999:Timolol
Effektivnoct sochetaniia pilokarpina i timolola maleata v lechenii glaukomi.