Coagulation factor V gene mutation increases the risk of venous thrombosis in behçet's disease.
We investigated the prevalence of the coagulation factor V gene G1691A mutation in 64 patients with Behçet's disease (BD) and in 107 apparently healthy individuals. The mutation was present in the heterozygous state in 37.5% of the patients with a history of deep vein thrombosis (12/32) and in 9.4% of the patients without any thrombotic event (3/32). Eleven healthy individuals were also heterozygous for the mutation (10.3%). The prevalence of the mutation in BD patients with and without thrombosis was significantly different (P = 0.0079). We conclude that the factor V gene mutation may play a major role in the development of venous thrombosis in BD.
Gül
A
A
Department of Internal Medicine, Istanbul Medical School, Turkey.
Ozbek
U
U
Oztürk
C
C
Inanç
M
M
Koniçe
M
M
Ozçelik
T
T
D000293:Adolescent; D000328:Adult; D001528:Behcet Syndrome / Q000150:complications* / Q000235:genetics; D005165:Factor V / Q000235:genetics*; D005260:Female; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D012307:Risk Factors; D013924:Thrombophlebitis / Q000209:etiology* / Q000235:genetics*
D005165:Factor V