Synthesis, chemical and pharmacological properties of some 2,4-dioxo-1,2,3,4,5,6,7,8-octahydropyrimido [4,5-d]pyrimidines.
Synthesis of 6-substituted 2,4-dioxo-1,2,3,4,5,6,7,8-octahydropyrimido[4,5-d]pyrimidines [III-VI] obtained by cyclocondensation of 1-phenyl-6-aminouracil with formaline and the primary amines is described. Compounds III, V, VI in the Mannich reaction with secondary cyclic amines yield the corresponding 3-substituted N-aminomethyl derivatives VII-X. Some of them were active pharmacologically.
Sladowska
H
H
Department of Chemistry of Drugs, Wrocław University of Medicine, Poland.
Sieklucka-Dziuba
M
M
Rajtar
G
G
Wydro
R
R
Kleinrok
Z
Z
D000588:Amines / Q000737:chemistry; D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis / Q000737:chemistry; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000737:chemistry; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D004232:Diuretics / Q000138:chemical synthesis / Q000737:chemistry; D015195:Drug Design; D005260:Female; D005557:Formaldehyde / Q000737:chemistry; D007166:Immunosuppressive Agents / Q000138:chemical synthesis / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010146:Pain / Q000188:drug therapy; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D014498:Uracil / Q000031:analogs & derivatives / Q000737:chemistry; D014665:Vasodilator Agents / Q000138:chemical synthesis / Q000737:chemistry
D000588:Amines; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D004232:Diuretics; D007166:Immunosuppressive Agents; D011743:Pyrimidines; D014665:Vasodilator Agents; D005557:Formaldehyde; D014498:Uracil; C013400:6-aminouracil