Directing alternative splicing: cast and scenarios.
Recent progress in the study of alternative RNA splicing indicates that the interaction of RNA-binding proteins with specific target elements modulates splice site recognition and spliceosome assembly. The identity of splicing signals, the presence of modulating elements and differences in the distribution of RNA-binding proteins are key determinants involved in the tissue-specific regulation of splice site selection.
Chabot
B
B
Departement De Microbiologie et Infectiologie, Faculté De Médecine, Université De Sherbrooke, Québec, Canada. b.chabot@courrier.usherb.ca
D017398:Alternative Splicing; D000818:Animals; D004330:Drosophila / Q000235:genetics; D005786:Gene Expression Regulation; D008322:Mammals; D008957:Models, Genetic; D017381:Spliceosomes / Q000235:genetics