title: Double renal allografts successfully increase utilization of kidneys from older donors within a single organ procurement organization.
abstract: BACKGROUND
  In 1994, a policy of double renal allografting (DUAL) was used at two centers within our local organ procurement organization to increase utilization of kidneys from older donors that would otherwise be discarded. Both kidneys from an older donor (age > 60 years) were selectively transplanted into a single adult recipient.
  
  
  METHODS
  The relative impact of a DUAL policy on the utilization of older donor kidneys is examined for the period of April 1994 to April 1996. Actual utilization is compared with the hypothetical case in which a DUAL policy is not present.
  
  
  RESULTS
  In the actual setting, a total of 75 kidneys from older donors (> 60 years) were accepted for transplantation. Thirty-six kidneys were transplanted as singlets, and 16 additional kidneys were transplanted as DUAL renal allografts. Thus, a 44% increase in transplantable kidneys, and a 22% increase in patients transplanted with kidneys from older donors, was realized. In the actual setting, 23 older kidneys were discarded; without the DUAL policy, 39 kidneys would have been deemed untransplantable. When compared with the actual (n = 52) and hypothetical number of kidneys transplanted without a policy of DUAL transplantation (n = 36), the DUAL policy significantly increased the utilization of older donor kidneys (P = 0.01). The actuarial 1-year graft survival rate of the dual kidneys was 100%, with a mean follow-up of 11.1 +/- 2.9 months. Mean 6-month and 1-year serum creatinine level were 1.76 +/- 0.4 and 1.63 +/- 0.6 mg/dl, respectively.
  
  
  CONCLUSIONS
  A DUAL policy significantly increased the number of older donor kidneys transplanted in a single organ procurement organization and reduced the rate of discard of older donor kidneys over a 2-year period. Long-term follow-up is necessary to substantiate satisfactory graft function in DUAL from older donors.
authors.affiliation: Department of Surgery, University of Maryland School of Medicine, Baltimore, USA.
authors.forename: L B
authors.initials: LB
authors.lastname: Johnson
authors.forename: P C
authors.initials: PC
authors.lastname: Kuo
authors.forename: E J
authors.initials: EJ
authors.lastname: Schweitzer
authors.forename: L E
authors.initials: LE
authors.lastname: Ratner
authors.forename: D K
authors.initials: DK
authors.lastname: Klassen
authors.forename: E W
authors.initials: EW
authors.lastname: Hoehn-Saric
authors.forename: A
authors.initials: A
authors.lastname: dela Torre
authors.forename: M R
authors.initials: MR
authors.lastname: Weir
authors.forename: J
authors.initials: J
authors.lastname: Strange
authors.forename: S T
authors.initials: ST
authors.lastname: Bartlett
mesh_terms: D000367:Age Factors; D000368:Aged; D006085:Graft Survival / Q000502:physiology; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology; D008875:Middle Aged; D014019:Tissue Donors; D009927:Tissue and Organ Procurement / Q000458:organization & administration; D014184:Transplantation, Homologous / Q000502:physiology