title: Development of minimally differentiated acute myeloblastic leukemia with novel isochromosome 18p and antecedent aplastic anemia.
abstract: We describe a case of acute myeloblastic leukemia with a novel isochromosome 18, i(18)(p10), preceded by aplastic anemia for six months. The patient is a cotton grower chronically exposed to pesticides. The significance of this chromosomal abnormality is unknown. The possible relationship to the preceding history of aplastic anemia and occupational pesticide exposure is speculated on. The possible mechanism of the association of acute leukemia and aplastic anemia is discussed.
authors.affiliation: Division of Oncology/Hematology, Texas Tech University Health Sciences Center, Lubbock 79430, USA.
authors.forename: Y K
authors.initials: YK
authors.lastname: Keung
authors.forename: E
authors.initials: E
authors.lastname: Cobos
authors.forename: D
authors.initials: D
authors.lastname: Morgan
authors.forename: V
authors.initials: V
authors.lastname: Tonk
mesh_terms: D000382:Agricultural Workers' Diseases / Q000188:drug therapy / Q000473:pathology; D000741:Anemia, Aplastic / Q000188:drug therapy / Q000473:pathology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D006801:Humans; D018404:Isochromosomes / Q000235:genetics*; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects; D010575:Pesticides / Q000009:adverse effects; D011289:Preleukemia / Q000188:drug therapy / Q000473:pathology*
chemical_list: D010575:Pesticides