T-cell lymphomas in v-Myb transgenic mice.
v-Myb, the transforming protein of avian myeloblastosis virus, causes acute myeloid leukemia in chickens. Similarly, truncation and rearrangement of the c-myb proto-oncogene to yield a v-Myb-like protein leads to myeloid and B cell lymphomas in chickens and mice, and may be a factor in a number of human cancers. To study the effects of deregulation of v-Myb on T cell development, we have generated lines of transgenic mice in which the v-Myb oncoprotein is expressed in a T-cell-specific fashion. Analysis of T cell development in the v-Myb transgenic mice shows that ectopic expression of v-Myb affects the ratio of helper to cytotoxic T cells, by increasing the number of CD4+ helper cells, and inhibits thymic involution, such that mature animals have elevated numbers of thymocytes and circulating mature T cells. In a significant proportion of older animals, high grade T cell lymphomas develop, demonstrating that v-Myb is oncogenic in T cells.
Badiani
P A
PA
CRC Centre for Cell and Molecular Biology, Institute of Cancer Research, London, UK.
Kioussis
D
D
Swirsky
D M
DM
Lampert
I A
IA
Weston
K
K
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology* / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology* / Q000378:metabolism; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics* / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000235:genetics* / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D020626:Oncogene Proteins v-myb; D000090063:Proto-Oncogene Mas; D015682:Retroviridae Proteins, Oncogenic / Q000378:metabolism*
C000715470:MAS1 protein, human; D020626:Oncogene Proteins v-myb; D000090063:Proto-Oncogene Mas; D015682:Retroviridae Proteins, Oncogenic