Living related liver transplantation in children with hypoxemia related to intrapulmonary shunting.
Living related liver transplantation (LRLT) was performed in seven children with hypoxemia related to intrapulmonary shunting. Based on the degree of the shunt ratio calculated by technetium 99m macroaggregated albumin (MAA) scintigraphy, the seven patients were classified in the moderate (shunt ratio under 40%, n = 4) or severe group (shunt ratio over 40%, n = 3). While PaO2 was maintained over 60 mmHg in the moderate group, that in the severe group continued at a low level of under 40 mmHg in the early postoperative period. However, 48 h after surgery the arterial ketone body ratio recovered to a safe level of 1.0 in both groups. Values of aspartate aminotransferase and serum total bilirubin decreased at a constant rate in both groups. Six patients survived, but one died of portal vein thrombosis on the 53rd postoperative day. Five of six surviving patients recovered from hypoxemia. We concluded that the transplanted liver can tolerate the stress of severe hypoxemia after LRLT.
Uemoto
S
S
Second Department of Surgery, Kyoto University Hospital, Japan.
Inomata
Y
Y
Tanaka
K
K
Ozaki
N
N
Egawa
H
H
Okajima
H
H
Nishizawa
H
H
Yabe
S
S
Yamaoka
Y
Y
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000209:etiology / Q000503:physiopathology*; D007657:Ketone Bodies / Q000097:blood; D016031:Liver Transplantation; D008297:Male; D010100:Oxygen / Q000097:blood
D007657:Ketone Bodies; D010100:Oxygen