title: Reversible hepatotoxicity of paroxetine in a patient with major depression.
abstract: Selective serotonin reuptake inhibitors (SSRIs) are becoming widely used because of their favorable side-effect profile and their safety in overdose. We report about a patient with recurring major depression (DSM-IIIR) who was treated with paroxetine and developed a severe hepatotoxic reaction, which was reversed after withdrawal of the drug. Individual, patient-related causes for this side-effect were not found. To our knowledge, this is the first published case of a probably paroxetine-induced severe hepatotoxicity. Hepatotoxicity should be taken into account as a rare complication that may occur not only with tricyclic antidepressants (TCAs) but also with SSRIs.
authors.affiliation: Department of Psychiatry, Ludwig Maximilians University, Munich, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Helmchen
authors.forename: R J
authors.initials: RJ
authors.lastname: Boerner
authors.forename: R
authors.initials: R
authors.lastname: Meyendorf
authors.forename: U
authors.initials: U
authors.lastname: Hegerl
mesh_terms: D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000201:enzymology; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008875:Middle Aged; D017374:Paroxetine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D018687:Antidepressive Agents, Second-Generation; D017374:Paroxetine