title: Pulse wave velocity measurement by cross-correlation of Doppler velocity signals. Application to elderly volunteers during training.
abstract: Pulse wave velocity (PWV) measurement is widely used for the indirect assessment of arterial wall distensibility. In order to improve its measurement technique, we built a system performing the calculation of the cross-correlation function of Doppler velocity signals. In 12 normal subjects and 10 patients, the mean difference between duplicate measurements was 0.7 +/- 7.8% (NS). We tested this technique in 15 elderly volunteers before and after a three months training period. Brachial and tibial systolic blood pressure decreased respectively from 18.1 +/- 2.2 kPa to 16.7 +/- 1.9 kPa (p = 0.008) and from 21.1 +/- 3.4 kPa to 18.4 +/- 2.5 kPa (p = 0.003), while lower limb PWV decreased from 8.96 +/- 1.26 to 7.92 +/- 1.22 m.s-1 (p = 0.016). Therefore, automatic PWV measurement using the cross-correlation technique allows to demonstrate training induced changes in PWV, although concomitant changes in blood pressure must be considered in their interpretation.
authors.affiliation: Vascular Laboratory, Centre Hospitalier Universitaire, Nîmes, France.
authors.forename: M
authors.initials: M
authors.lastname: Dauzat
authors.forename: G
authors.initials: G
authors.lastname: Deklunder
authors.forename: B
authors.initials: B
authors.lastname: Adam
authors.forename: A
authors.initials: A
authors.lastname: de Césare
authors.forename: J
authors.initials: J
authors.lastname: Ayoub
authors.forename: J
authors.initials: J
authors.lastname: Massé-Biron
authors.forename: C
authors.initials: C
authors.lastname: Préfaut
authors.forename: P
authors.initials: P
authors.lastname: Péronneau
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D001794:Blood Pressure; D003187:Compliance; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging; D018056:Hemorheology / Q000295:instrumentation / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D011674:Pulse; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D018709:Statistics, Nonparametric; D016909:Tibial Arteries / Q000000981:diagnostic imaging; D018608:Ultrasonography, Doppler / Q000295:instrumentation*; D016138:Walking / Q000502:physiology