title: Site of peptic ulcer. comparison of hydrochloric acid output, pepsinogen and gastrin serum levels.
abstract: OBJECTIVE
  Basal (BAO) and maximum (PAO) hydrochloric acid output after Histalog stimulation, basal pepsinogen (SPL-B), at 60 (SPL-60) and at 90 minutes (SPL-90), and basal gastrin (BG) levels were measured and compared in different gastric (GU) and duodenal (DU) ulcer sites.
  
  
  METHODS
  Fifty nine patients with peptic ulcer were grouped according to Johnson's classification for gastric ulcers: type I (15), type II (16) type III (12) GU and (16) DU. Fifteen normal subjects were studied as controls.
  
  
  RESULTS
  The BAO was greater in the DU than in the control or GU groups. No significant difference was noted in the production of hydrochloric acid after stimulation with Histalog. The SPL-B, at 60 and at 90 minutes was higher in type II GU than in the DU group and controls. The SPL-60 was higher in type II GU patients than in type III GU. Basal gastrin was higher in group DU and types II and III GU compared to the type I GU patients and controls.
  
  
  CONCLUSIONS
  The topographic criteria for differentiating peptic ulcers has low discrimination capacity based on comparison of mean values of HCl acid production, pepsinogen and gastrin serum levels both basal and after stimulation with Histalog due to heterogeneity of these variables in group studies. In these studies, peptic ulcers from different sites should not be grouped as distinct entities except for type II gastric ulcers.
authors.affiliation: Department of Gastroenterology, Sao Paulo Faculty of Medicine, Brazil.
authors.forename: P
authors.initials: P
authors.lastname: Engler-Pinto Júnior
authors.forename: J
authors.initials: J
authors.lastname: Gama-Rodrigues
authors.forename: F P
authors.initials: FP
authors.lastname: Lopasso
authors.forename: A C
authors.initials: AC
authors.lastname: Cordeiro
authors.forename: A
authors.initials: A
authors.lastname: Saez-Alquezar
authors.forename: A A
authors.initials: AA
authors.lastname: Laudanna
authors.forename: H W
authors.initials: HW
authors.lastname: Pinotti
mesh_terms: D001625:Betazole; D005260:Female; D005755:Gastrins / Q000097:blood*; D005765:Gastrointestinal Agents; D006801:Humans; D006851:Hydrochloric Acid / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010435:Pepsinogens / Q000097:blood*; D010437:Peptic Ulcer / Q000145:classification* / Q000378:metabolism*; D013997:Time Factors
chemical_list: D005755:Gastrins; D005765:Gastrointestinal Agents; D010435:Pepsinogens; D001625:Betazole; D006851:Hydrochloric Acid