A novel mechanism of action of the immunomodulatory drug, leflunomide: augmentation of the immunosuppressive cytokine, TGF-beta 1, and suppression of the immunostimulatory cytokine, IL-2.
Cao
W W
WW
Probe ID/Department, Chiron Corp, Emeryville, California, USA.
Kao
P N
PN
Aoki
Y
Y
Xu
J C
JC
Shorthouse
R A
RA
Morris
R E
RE
D002478:Cells, Cultured; D015870:Gene Expression; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007376:Interleukin-2 / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D007555:Isoxazoles / Q000494:pharmacology*; D019169:Jurkat Cells; D000077339:Leflunomide; D014158:Transcription, Genetic; D016212:Transforming Growth Factor beta / Q000096:biosynthesis*
D007166:Immunosuppressive Agents; D007376:Interleukin-2; D007555:Isoxazoles; D016212:Transforming Growth Factor beta; D000077339:Leflunomide