title: [Treatment of the epilepsy: new drugs].
abstract: New advances in the knowledge on the physiopathogenesis of epilepsy and their relationship with sodium and calcium channels and with the excitatory and inhibitory neurotransmitters actions have recently been developed. These knowledges have produced the research on new antiepileptic drugs which action places have specially based on the known impaired mechanisms. As the conventional drugs, the new therapeutic tool have produced a great advance in the therapy of epileptic events, specially in the refractory seizures, which represent 25-30% of the whole group of epilepsies. In the present work, we review the new drugs, ones have been registered, in order to their pharmacological properties, their efficacy their safety and their clinical indications as first-election or adjuvant drugs. We also discuss their known side adverse effects.
authors.affiliation: División de Neurología, Hospital de Niños R. Gutièrrez, Buenos Aires, Argentina.
authors.forename: J
authors.initials: J
authors.lastname: Grippo
mesh_terms: D000085:Acetates / Q000627:therapeutic use; D000588:Amines; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants / Q000627:therapeutic use; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000627:therapeutic use; D002220:Carbamazepine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000078306:Clobazam; D003509:Cyclohexanecarboxylic Acids; D004148:Dioxolanes / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy*; D000078328:Felbamate; D005632:Fructose / Q000031:analogs & derivatives / Q000627:therapeutic use; D000077206:Gabapentin; D006801:Humans; D007555:Isoxazoles / Q000627:therapeutic use; D000077213:Lamotrigine; D000078330:Oxcarbazepine; D048448:Phenylcarbamates; D011409:Propylene Glycols / Q000627:therapeutic use; D000077236:Topiramate; D014227:Triazines / Q000627:therapeutic use; D020888:Vigabatrin; D000078305:Zonisamide; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000085:Acetates; D000588:Amines; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001570:Benzodiazepinones; D003509:Cyclohexanecarboxylic Acids; D004148:Dioxolanes; D007555:Isoxazoles; D048448:Phenylcarbamates; D011409:Propylene Glycols; D014227:Triazines; D000077236:Topiramate; D001569:Benzodiazepines; D000078306:Clobazam; D005632:Fructose; D002220:Carbamazepine; D000078305:Zonisamide; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D020888:Vigabatrin; C021092:stiripentol; D000077213:Lamotrigine; D000078330:Oxcarbazepine; D000078328:Felbamate
vernacular_title: Tratamiento de la epilepsia: nuevas drogas.