title: Urinary cGMP excretion after hormone replacement therapy in postmenopausal women.
abstract: It is well established that estrogens and progestogens are able to influence the vasotonus in postmenopausal women. The present study was undertaken to find out if the NO/cGMP-system is involved in this hormone action. Urinary cGMP excretion which can reflect intracellular cGMP production elicited by NO (EDRF) was investigated in 20 postmenopausal women. In an open cross-over study design norethisterone acetate was administered orally for 8 days, estradiol valerate orally for 9 days and a combination of both substances for 12 days. After all three treatment phases urinary cGMP expressed as percentage of the pretreatment value was increased at a statistically significant level. Due to high individual variations no significant differences could be found among the values after the three treatment phases. It was concluded that the NO/cGMP-system may play a role in maintaining vasotonus in postmenopausal women under hormone replacement therapy.
authors.affiliation: Department of Obstetrics & Gynecology, University of Tübingen, Germany.
authors.forename: A O
authors.initials: AO
authors.lastname: Mueck
authors.forename: H
authors.initials: H
authors.lastname: Seeger
authors.forename: S
authors.initials: S
authors.lastname: Kasspohl-Butz
authors.forename: A T
authors.initials: AT
authors.lastname: Teichmann
authors.forename: T H
authors.initials: TH
authors.lastname: Lippert
mesh_terms: D000284:Administration, Oral; D018592:Cross-Over Studies; D006152:Cyclic GMP / Q000652:urine*; D004958:Estradiol / Q000031:analogs & derivatives / Q000627:therapeutic use; D015914:Estrogen Replacement Therapy; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D009640:Norethindrone / Q000031:analogs & derivatives / Q000627:therapeutic use; D000077563:Norethindrone Acetate; D017698:Postmenopause / Q000187:drug effects / Q000652:urine*; D016896:Treatment Outcome
chemical_list: D004966:Estrogens, Conjugated (USP); D004958:Estradiol; D000077563:Norethindrone Acetate; D006152:Cyclic GMP; D009640:Norethindrone