title: Continuous infusion of methylene blue for septic shock.
abstract: Nitric oxide has been determined to be a potential mediator of the haemodynamic changes associated with sepsis. The haemodynamic eects of nitric oxide can be partially antagonised by methylene blue, through inhibition of the enzyme, guanylate cyclase. The case report presented here demonstrates a beneficial haemodynamic eect of continuous infusion of methylene blue during sepsis. These findings could be extrapolated to other patients or prompt additional research.
authors.affiliation: St Paul's Hospital, Vancouver, British Columbia, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Brown
authors.forename: D
authors.initials: D
authors.lastname: Frankl
authors.forename: T
authors.initials: T
authors.lastname: Phang
mesh_terms: D000931:Antidotes / Q000627:therapeutic use*; D016984:Enterococcus faecium; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008751:Methylene Blue / Q000627:therapeutic use*; D008875:Middle Aged; D012772:Shock, Septic / Q000188:drug therapy*
chemical_list: D000931:Antidotes; D008751:Methylene Blue