title: Dose monitoring for boron neutron capture therapy using a reactor-based epithermal neutron beam.
abstract: The aims of this study were (i) to determine the variation with time of the relevant beam parameters of a clinical reactor-based epithermal neutron beam for boron neutron capture therapy (BNCT) and (ii) to test a monitoring system for its applicability to monitor the dose delivered to the dose specification point in a patient treated with BNCT. For this purpose two fission chambers covered with Cd and two GM counters were positioned in the beam-shaping collimator assembly of the epithermal neutron beam. The monitor count rates were compared with in-phanton reference measurements of the thermal neutron fluence rate, the gamma-ray dose rate and the fast neutron dose rate, at a constant reactor power, over a period of 2 years. Differences in beam output, defined as the thermal neutron fluence rate at 2 cm depth in a phantom, of up to 15% were observed between various reactor cycles. A decrease in beam output of about 5% was observed in each reactor cycle. An unacceptable decrease of 50% in beam output due to malfunctioning of the beam filter assembly was detected. For safe and accurate treatment of patients, on-line monitoring of the beam is essential. Using the calibrated monitor system, the standard uncertainty in the total dose at depth due to variations with time of the beam output parameters has been reduced to a clinically acceptable value of 1% (one standard deviation).
authors.affiliation: The Netherlands Cancer Institute-Antoni van Leeuwenhoek Huis, Amsterdam, The Netherlands.
authors.forename: C P
authors.initials: CP
authors.lastname: Raaijmakers
authors.forename: E L
authors.initials: EL
authors.lastname: Nottelman
authors.forename: M W
authors.initials: MW
authors.lastname: Konijnenberg
authors.forename: B J
authors.initials: BJ
authors.lastname: Mijnheer
mesh_terms: D016754:Boron Neutron Capture Therapy / Q000295:instrumentation* / Q000379:methods*; D003037:Cobalt Radioisotopes; D005214:Fast Neutrons; D005720:Gamma Rays; D006801:Humans; D009502:Neutrons; D011879:Radiotherapy Dosage; D011881:Radiotherapy, Computer-Assisted; D015203:Reproducibility of Results; D013997:Time Factors
chemical_list: D003037:Cobalt Radioisotopes