title: Reactivation of recipient antibody to blood cell antigens soon after allogeneic bone marrow transplantation.
abstract: Reactivation of recipient antibody to HLA and red blood cell antigens is described in 8 patients after allogeneic bone marrow transplantation. These IgG antibodies can be detected between day 10 and day 40 after transplantation and, in 1 patient, can be shown to be antigen-independent. We hypothesize that, induced by graft recognition of recipient antigens, antigen-independent activation of sensitized recipient B cells takes place leading to transient antibody production.
authors.affiliation: Department of Transfusion Medicine, University Hospital, Tübingen, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Wernet
authors.forename: M
authors.initials: M
authors.lastname: Schnaidt
authors.forename: H
authors.initials: H
authors.lastname: Northoff
mesh_terms: D000906:Antibodies / Q000097:blood / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D016026:Bone Marrow Transplantation / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male; D014184:Transplantation, Homologous
chemical_list: D000906:Antibodies; D006680:HLA Antigens; D007074:Immunoglobulin G