title: [Withdrawal syndrome in 2 drug addicts after intravenous injection of buprenorphine?].
abstract: Adequate dosage of sublingual buprenorphine is now recommended for substitution treatment of severe opioid dependance. We report two cases of acute discomfort, probably linked to withdrawal syndrome, after an IV injection of high doses of buprenorphine in opiate dependant patients. Data on the pharmacokinetics and neurobiochemical aspects of buprenorphine are compared with those of other opiates. A major issue of this work is a guideline for inducing substitution treatment with this "unique" partial agonist/antagonist of endorphinic receptors.
authors.affiliation: Service de Médecine interne I, Hôpital Laennec, Paris.
authors.forename: L
authors.initials: L
authors.lastname: Gourarier
authors.forename: W
authors.initials: W
authors.lastname: Lowenstein
authors.forename: M
authors.initials: M
authors.lastname: Gisselbrecht
authors.forename: J M
authors.initials: JM
authors.lastname: Chauveau
authors.forename: C
authors.initials: C
authors.lastname: Haas
authors.forename: H
authors.initials: H
authors.lastname: Durand
mesh_terms: D000208:Acute Disease; D000328:Adult; D002047:Buprenorphine / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009294:Narcotics / Q000008:administration & dosage / Q000009:adverse effects*; D009293:Opioid-Related Disorders / Q000628:therapy; D013375:Substance Withdrawal Syndrome / Q000517:prevention & control*
chemical_list: D009294:Narcotics; D002047:Buprenorphine
vernacular_title: Syndrome de manque chez deux toxicomanes après injection intraveineuse de buprénorphine?