title: Ontogeny of CD40L [corrected] expression by activated peripheral blood lymphocytes in humans.
abstract: The CD40 ligand (CD40L) is a molecule expressed by activated T cells which plays a critical role in the regulation of B-cell responses, including differentiation into Ig-producing cells. Using the specific monoclonal antibody TRAP1 we have evaluated the ontogeny of CD40L expression in 97 normal individuals between birth and 50 years of age. The expression of CD40L is a function of age; it is severely reduced at birth, progressively increases during the first months of life, and reaches a plateau in the second decade. This progressive attainment of the ability to express CD40L is due to a process of maturation of the CD4 + subset, being significantly correlated with the expression of the CD45RO antigen.
authors.affiliation: Clinical Immunology Service, Spedali Civili, Brescia, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Brugnoni
authors.forename: P
authors.initials: P
authors.lastname: Airò
authors.forename: D
authors.initials: D
authors.lastname: Graf
authors.forename: M
authors.initials: M
authors.lastname: Marconi
authors.forename: C
authors.initials: C
authors.lastname: Molinari
authors.forename: D
authors.initials: D
authors.lastname: Braga
authors.forename: F
authors.initials: F
authors.lastname: Malacarne
authors.forename: A
authors.initials: A
authors.lastname: Soresina
authors.forename: A G
authors.initials: AG
authors.lastname: Ugazio
authors.forename: R
authors.initials: R
authors.lastname: Cattaneo
authors.forename: R A
authors.initials: RA
authors.lastname: Kroczek
authors.forename: L D
authors.initials: LD
authors.lastname: Notarangelo
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000911:Antibodies, Monoclonal / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D023201:CD40 Ligand; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D017493:Leukocyte Common Antigens / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008562:Membrane Glycoproteins / Q000096:biosynthesis* / Q000276:immunology; D008875:Middle Aged
chemical_list: D000911:Antibodies, Monoclonal; D008562:Membrane Glycoproteins; D023201:CD40 Ligand; D017493:Leukocyte Common Antigens