Allogeneic and xenogeneic grafts in pulmonate gastropod molluscs: fates of neural transplants.
Neural intracerebral allo- and xenografts in pulmonate gastropods demonstrated a variation in the tolerance of neural xenogeneic grafts that was dependent on the phylogenetic distance between the donor and the host. Like allografts, neural congeneric xenografts (Hp/Haa and H1/Haa) of cerebral ganglia (CG) were tolerated and restored growth in juvenile mesocerebrum-deprived (Haa) snails. However, CG neural xenografts between different genera of stylommatophorans (Achatina fulica/Haa) or between genera of different orders (Lymnaea stagnalis: Basommatophora/Haa: Stylommatophora) revealed an interspecific histoincompatibility. These results, compared with those described by other authors, suggest that gastropods possess mechanisms for the recognition of non-self that depend on the organ considered and the phylogenetic distance separating host and donor. Research should now attempt to identify the factors responsible for graft destruction.
Gomot
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Laboratoire de Biologie des Organismes et Ecosystèmes, UFR des Sciences et Techniques, Besançon, France.
Gomot
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D000818:Animals; D016380:Brain Tissue Transplantation; D017952:Ganglia, Invertebrate / Q000637:transplantation; D006372:Helix, Snails / Q000254:growth & development / Q000276:immunology*; D008195:Lymnaea / Q000254:growth & development / Q000276:immunology*; D009474:Neurons / Q000502:physiology / Q000637:transplantation*; D013045:Species Specificity; D014183:Transplantation, Heterologous / Q000276:immunology*; D014184:Transplantation, Homologous / Q000276:immunology*