Thyroidal extracellular glutathione peroxidase: a potential regulator of thyroid-hormone synthesis.
Human thyrocytes were found to synthesize and secrete the selenoenzyme extracellular glutathione peroxidase (E-GPX), a process which was controlled by the Ca2+/phosphoinositol second-messenger cascade. The potential involvement of thyroidal E-GPX in the regulation of thyroid-hormone synthesis and in the protection of the thyrocyte from peroxidative damage is discussed.
Howie
A F
AF
Cellular Endocrinology Unit, University Department of Clinical Biochemistry, Royal Infirmary, Edinburgh, U.K.
Walker
S W
SW
Akesson
B
B
Arthur
J R
JR
Beckett
G J
GJ
D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000494:pharmacology; D015153:Blotting, Western; D020126:Brefeldin A; D000001:Calcimycin / Q000494:pharmacology; D002478:Cells, Cultured; D003470:Culture Media / Q000378:metabolism; D003517:Cyclopentanes / Q000494:pharmacology; D004591:Electrophoresis, Polyacrylamide Gel; D005110:Extracellular Space / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D011506:Proteins / Q000378:metabolism; D051140:Selenoproteins; D018038:Sodium Selenite / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D013961:Thyroid Gland / Q000187:drug effects / Q000201:enzymology*; D013963:Thyroid Hormones / Q000096:biosynthesis*; D013972:Thyrotropin / Q000494:pharmacology
D003470:Culture Media; D003517:Cyclopentanes; D011506:Proteins; D051140:Selenoproteins; D013963:Thyroid Hormones; D020126:Brefeldin A; D015124:8-Bromo Cyclic Adenosine Monophosphate; D000001:Calcimycin; D013972:Thyrotropin; D005979:Glutathione Peroxidase; D018038:Sodium Selenite; D013755:Tetradecanoylphorbol Acetate