[Study of plasma and hepatic hydrolysis of nitroxinil derivatives].
Seven esters derivatives of Nitroxinil were prepared and their structures were assigned by IR and 1H-NMR spectroscopy. The rate of plasma and hepatic hydrolysis were evaluated in vitro in sheep and rabbit. In view of this profile of activity, pivaloyl derivative merits evaluation, in vivo.
Baziard-Mouysset
G
G
Laboratoire de Chimie Pharmaceutique, Faculté de Pharmacie, Toulouse.
Alvinerie
M
M
Galtier
P
P
Ane-Margail
M
M
Floch
R
R
Payard
M
M
D000818:Animals; D006868:Hydrolysis; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D009611:Nitroxinil / Q000031:analogs & derivatives* / Q000097:blood* / Q000378:metabolism; D011355:Prodrugs; D011817:Rabbits; D012756:Sheep
D011355:Prodrugs; D009611:Nitroxinil
Etude de l'hydrolyse plasmatique et hépatique de dérivés du Nitroxinil.