The influence of selected general anesthetics on pharmacokinetic parameters of some antiarrhythmic drugs in rabbits. Part III. Propranolol.
The influence of general anesthesia with thiopental (10 mg/kg), ketamine (4 mg/kg), or propofol (10 mg/kg) on the propranolol (0.3 mg/kg) pharmacokinetic parameters was studied in rabbits. It was established that during thiopental or propofol anesthesia the levels of propranolol were significantly higher than in control animals. The following main changes in propranolol pharmacokinetic parameters were found: 1) increase of the distribution rate constant during propofol anesthesia 2) prolonged biological half-life and mean residence time during thiopental or propofol anesthesia 3) increase of the area under drug level curve during thiopental or propofol anesthesia 4) decrease of systemic clearance and volume of distribution during thiopental or propofol anesthesia. The slightest influence on propranolol pharmacokinetics was exerted by ketamine anesthesia.
Orszulak-Michalak
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Department of Pharmacodynamics, Medical University of Lodz.
D000777:Anesthetics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001682:Biological Availability; D004305:Dose-Response Relationship, Drug; D005260:Female; D006207:Half-Life; D007275:Injections, Intravenous; D007649:Ketamine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology*; D011433:Propranolol / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D011817:Rabbits; D013874:Thiopental / Q000008:administration & dosage / Q000494:pharmacology*
D000777:Anesthetics; D000889:Anti-Arrhythmia Agents; D007649:Ketamine; D011433:Propranolol; D013874:Thiopental; D015742:Propofol