title: The function of transgenic human DAF-expressing porcine livers during hemoperfusion with human blood.
abstract: Extracorporal pig liver perfusion could bridge the deadly problem of acute human liver failure. However, preformed natural antibodies and complement activation (CA) are the predominant mechanisms of hyperacute xenogeneic rejection. The blockade of both pathways of CA in the xenograft, using transgenic livers expressing human decay accelerating factor on the endothelial surface results in prolonged graft survival and lower release of mediators.
authors.affiliation: Institute for Surgical Research, Grosshadern, Ludwig-Maximilians-University, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Pöhlein
authors.forename: A
authors.initials: A
authors.lastname: Pascher
authors.forename: M
authors.initials: M
authors.lastname: Storck
authors.forename: V K
authors.initials: VK
authors.lastname: Young
authors.forename: W
authors.initials: W
authors.lastname: König
authors.forename: D
authors.initials: D
authors.lastname: Abendroth
authors.forename: M
authors.initials: M
authors.lastname: Wick
authors.forename: J
authors.initials: J
authors.lastname: Thiery
authors.forename: D J
authors.initials: DJ
authors.lastname: White
authors.forename: C
authors.initials: C
authors.lastname: Hammer
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D018958:CD55 Antigens / Q000235:genetics / Q000502:physiology*; D006464:Hemoperfusion; D006801:Humans; D008099:Liver / Q000502:physiology*; D016031:Liver Transplantation / Q000276:immunology*; D013552:Swine; D014183:Transplantation, Heterologous / Q000276:immunology*
chemical_list: D018958:CD55 Antigens