title: [Immunohistochemical studies of the pancreas in newborns with diabetic fetopathy].
abstract: The number and the size of the Langerhans islets in the pancreata of most of investigated cases with diabetic foetopathy is increased (polynesia and macronesia). The B endocrine cells are immunoreactive for both insulin and IAPP, the reaction for IAPP being weaker in comparison with the controls. In one of the cases (the mother with long history of treated type 1 diabetes, who died during delivery) no presence of insulin-immunoreactive of PAF positive B cells is discovered. The reactivity for glucagon and somatostatin in the pancreata with diabetic foetopathy is found to be similar to the controls. In the vicinity of some islets lymphoid cell infiltrations are observed.
authors.forename: R
authors.initials: R
authors.lastname: Zhablenska
authors.forename: V
authors.initials: V
authors.lastname: Makaveeva
authors.forename: S
authors.initials: S
authors.lastname: Ismail
authors.forename: V
authors.initials: V
authors.lastname: Koleva
authors.forename: P
authors.initials: P
authors.lastname: Petkov
mesh_terms: D000682:Amyloid / Q000378:metabolism; D003920:Diabetes Mellitus / Q000151:congenital* / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005315:Fetal Diseases / Q000378:metabolism* / Q000473:pathology; D005934:Glucagon / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D007328:Insulin / Q000378:metabolism; D058228:Islet Amyloid Polypeptide; D007515:Islets of Langerhans / Q000378:metabolism* / Q000473:pathology; D008297:Male; D013004:Somatostatin / Q000378:metabolism
chemical_list: D000682:Amyloid; D007328:Insulin; D058228:Islet Amyloid Polypeptide; D013004:Somatostatin; D005934:Glucagon
vernacular_title: Imunokhistokhimichni izsledvaniia na pankreasa na novorodeni s diabetna fetopatiia.