Lectin-like receptor for alpha 1-acid glycoprotein in the epithelium of the rat prostate gland and seminal vesicles.
BACKGROUND
A receptor for alpha 1-acid glycoprotein glycoforms AGP-B and AGP-C in the epithelium of the rat prostate gland and seminal vesicles is described.


METHODS
The interaction between AGP-glycoforms and their receptor is a lectin-like interaction confirmed by inhibition of the binding by mannose and N-Acetyl-D-glucosamine.


RESULTS
In vitro the receptor was also inhibited by the steroid hormones cortisone, aldosterone, progesterone, and estradiol, but not by testosterone. A significant regional variation in the expression of AGP-lectin receptor and in the localization of AGP was seen in rat prostate and seminal vesicles. The localization of the AGP lectin receptor is compared to the localization of glycoprotein AGP, and small differences are found.


CONCLUSIONS
It is proposed the AGP receptors in the prostate and seminal vesicles belong to a group of lectins in the control of differentiation and organ formation.
Andersen
U O
UO
Protein Laboratory, Faculty of Health Sciences, University of Copenhagen, Denmark.
Bøg-Hansen
T C
TC
Kirkeby
S
S
D000450:Aldosterone / Q000494:pharmacology; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D003348:Cortisone / Q000494:pharmacology; D004847:Epithelial Cells; D004848:Epithelium / Q000737:chemistry / Q000502:physiology; D004958:Estradiol / Q000494:pharmacology; D007150:Immunohistochemistry; D008297:Male; D009961:Orosomucoid / Q000378:metabolism* / Q000502:physiology; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; D011374:Progesterone / Q000494:pharmacology; D011467:Prostate / Q000737:chemistry* / Q000166:cytology / Q000502:physiology; D051381:Rats; D011956:Receptors, Cell Surface / Q000032:analysis* / Q000187:drug effects / Q000378:metabolism*; D011975:Receptors, Mitogen / Q000032:analysis* / Q000187:drug effects / Q000378:metabolism*; D012669:Seminal Vesicles / Q000737:chemistry* / Q000166:cytology / Q000502:physiology
D009961:Orosomucoid; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D011975:Receptors, Mitogen; C032193:glycoprotein receptor GPIb-IX; D000450:Aldosterone; D011374:Progesterone; D004958:Estradiol; D003348:Cortisone