Translocation (6;9;22)(p25;q34;q11.2) identified by FISH in acute leukemia.
Fluorescence in situ hybridization (FISH) study of bone marrow cells from a patient with clinically and immunologically acute leukemia showed that an apparent t(6;22)(p25; q11.2) identified by routine banding techniques concealed a complex t(6;9;22)(p25;q34; q11.2). This observation further supports the importance of FISH in those cases where a chromosome rearrangement could not be reliably detected by conventional cytogenetic study.
González
G J
GJ
División de Genética, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México.
Notohamiprodjo
M
M
D000208:Acute Disease; D000328:Adult; D002871:Chromosome Banding; D002892:Chromosomes, Human, Pair 22; D002896:Chromosomes, Human, Pair 6; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D014178:Translocation, Genetic