Foreign body reaction to exogenous pulmonary surfactant in an infant with hydrops and cardiomyopathy.
We present a hydropic infant who received exogenous surfactant and who had Noonan phenotype with hypertrophic cardiomyopathy. The infant had clinically diagnosed stridor for which bronchoscopy did not identify an origin. He died at 30 days of age. The bronchioles showed numerous eosinophilic plugs with a foreign body giant cell reaction. The plugs were positively immunostained with anti-aposurfactant protein B.
Bendon
R W
RW
Department of Pathology, Kosair Children's Hospital, Louisville, KY 40232-5070, USA.
Greenberg
J
J
Heffelfinger
S
S
D009202:Cardiomyopathies / Q000473:pathology* / Q000628:therapy; D017809:Fatal Outcome; D005549:Foreign-Body Reaction / Q000139:chemically induced / Q000473:pathology*; D006801:Humans; D015160:Hydrops Fetalis / Q000473:pathology* / Q000628:therapy; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D011510:Proteolipids / Q000009:adverse effects* / Q000627:therapeutic use; D011663:Pulmonary Surfactants / Q000009:adverse effects* / Q000627:therapeutic use
D011510:Proteolipids; D011663:Pulmonary Surfactants