title: Transcatheter arterial renal and adrenal embolization with iohexol-ethanol solutions. Animal experimental study and clinical application.
abstract: OBJECTIVE
  The authors compared the embolic effect of radiolucent absolute ethanol (AE) with that of a radiopaque iohexol-ethanol (IES) solution for renal ablation in dogs and for the destruction of human aldosteronomas by the technique of transcatheter arterial embolization (TAE) to test whether IES can be an alternative to AE.
  
  
  METHODS
  The embolic agents were infused through a balloon catheter into the renal arteries of 17 dogs (9 infused with 0.3 mL/kg AE; 8 infused with IES). The immediate and parenchyma were compared between the two groups. Transcatheter arterial embolization with IES also was performed in three humans with unilateral aldosteronoma.
  
  
  RESULTS
  The IES was visualized faintly under fluoroscopy in all dogs. There were no significant differences in embolic effects between the AE and IES. Three patients with aldosteronoma were treated successfully by TAE with IES.
  
  
  CONCLUSIONS
  The IES can be used as a "visible ethanol" to improve the safety and ease of ethanol embolization.
authors.affiliation: Department of Radiology, Faculty of Medicine, Kagoshima University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Miyazono
authors.forename: K
authors.initials: K
authors.lastname: Ueno
authors.forename: M
authors.initials: M
authors.lastname: Nakajo
authors.forename: H
authors.initials: H
authors.lastname: Nishida
authors.forename: H
authors.initials: H
authors.lastname: Inoue
authors.forename: S
authors.initials: S
authors.lastname: Tsuchimochi
authors.forename: H
authors.initials: H
authors.lastname: Hokotate
authors.forename: H
authors.initials: H
authors.lastname: Yoshida
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000098:blood supply / Q000175:diagnosis / Q000628:therapy*; D000328:Adult; D000818:Animals; D002404:Catheterization; D003287:Contrast Media / Q000008:administration & dosage*; D004285:Dogs; D004621:Embolization, Therapeutic / Q000379:methods*; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D005471:Fluoroscopy; D005500:Follow-Up Studies; D006801:Humans; D007261:Infusions, Intra-Arterial; D007472:Iohexol / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012077:Renal Artery; D012997:Solvents / Q000008:administration & dosage*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media; D012997:Solvents; D000431:Ethanol; D007472:Iohexol