title: Interaction of Salmonella typhi strains with cultured human monocyte-derived macrophages.
abstract: Human monocyte-derived macrophages (MDM) provided this laboratory with a tool to develop a primary-cell assay for evaluating the relative virulence of newly constructed Salmonella typhi carrier strains. In this study, the interaction with and survival within MDM were compared for delta aroA143-attenuated strains, wild-type virulent strains, and the current oral-vaccine strain, Ty21a.
authors.affiliation: Department of Bacterial Diseases, Walter Reed Army Institute of Research, Washington, D.C. 20307-5100, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Sizemore
authors.forename: E A
authors.initials: EA
authors.lastname: Elsinghorst
authors.forename: L C
authors.initials: LC
authors.lastname: Eck
authors.forename: A A
authors.initials: AA
authors.lastname: Branstrom
authors.forename: D L
authors.initials: DL
authors.lastname: Hoover
authors.forename: R L
authors.initials: RL
authors.lastname: Warren
authors.forename: F A
authors.initials: FA
authors.lastname: Rubin
mesh_terms: D016915:AIDS Vaccines; D006801:Humans; D008264:Macrophages / Q000382:microbiology*; D009000:Monocytes / Q000382:microbiology*; D012485:Salmonella typhi / Q000472:pathogenicity*; D013045:Species Specificity; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic
chemical_list: D016915:AIDS Vaccines; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic