title: Selection response in finite populations.
abstract: Formulae were derived to predict genetic response under various selection schemes assuming an infinitesimal model. Account was taken of genetic drift, gametic (linkage) disequilibrium (Bulmer effect), inbreeding depression, common environmental variance, and both initial segregating variance within families (sigma AW02) and mutational (sigma M2) variance. The cumulative response to selection until generation t(CRt) can be approximated as [equation: see text] where Ne is the effective population size, sigma AW infinity 2 = Ne sigma M2 is the genetic variance within families at the steady state (or one-half the genic variance, which is unaffected by selection), and D is the inbreeding depression per unit of inbreeding. R0 is the selection response at generation 0 assuming preselection so that the linkage disequilibrium effect has stabilized. beta is the derivative of the logarithm of the asymptotic response with respect to the logarithm of the within-family genetic variance, i.e., their relative rate of change. R0 is the major determinant of the short term selection response, but sigma Me2 Ne and beta are also important for the long term. A selection method of high accuracy using family information gives a small Ne and will lead to a larger response in the short term and a smaller response in the long term, utilizing mutation less efficiently.
authors.affiliation: Institute of Cell, Animal and Population Biology, University of Edinburgh, United Kingdom.
authors.forename: M
authors.initials: M
authors.lastname: Wei
authors.forename: A
authors.initials: A
authors.lastname: Caballero
authors.forename: W G
authors.initials: WG
authors.lastname: Hill
mesh_terms: D000818:Animals; D005828:Genetics, Population; D006801:Humans; D008957:Models, Genetic; D008962:Models, Theoretical; D012641:Selection, Genetic