title: Synthesis, structures and biological activity of some N1-substituted 4-oxocinnolines.
abstract: The method of preparation of N1-substituted 4-hydroxycinnolines is described, by alkylation with methyl bromopropionate of the corresponding 4-hydroxycinnolines. The obtained esters were further converted into amides and hydrazides. The effect of several synthesized derivatives on central nervous system was studied. The structure of some of them was confirmed by the X-ray analysis.
authors.affiliation: Department of Pharmaceutical Chemistry and Drug Analysis, Faculty of Pharmacy, School of Medicine, Lódź, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Stańczak
authors.forename: W
authors.initials: W
authors.lastname: Kwapiszewski
authors.forename: Z
authors.initials: Z
authors.lastname: Ochocki
authors.forename: W
authors.initials: W
authors.lastname: Lewgowd
authors.forename: A
authors.initials: A
authors.lastname: Szadowska
authors.forename: W
authors.initials: W
authors.lastname: Pakulska
authors.forename: M L
authors.initials: ML
authors.lastname: Główka
mesh_terms: D000818:Animals; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003461:Crystallography; D005260:Female; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002491:Central Nervous System Agents