title: [Treatment of american cutaneous leishmaniasis, with lesions in the mucosa, using pentamidine isethionate].
abstract: Ten patients with mucosal lesions caused by American tegumental leishmaniasis were treated with pentamidine isethionate at the dose 4 mg/kg on alternate days by the intravenous route. The mean posology was 2,140 mg. Healing of the lesions occurred in 9 (90%) of the patients who completed treatment. There was no recurrence during a follow-up time of 1 to 24 months (mean, 7,7 months). One patient discontinued treatment before healing of the lesion because be developed diabetes mellitus. In 3 (30%) patients, blood exams showed increased urea and creatinine levels and leucopenia, which were corrected by increasing the interval between administrations of the drug. Pentamidine isethionate is efficient in bringing about cicatrization of the lesions but needs further evaluation in terms of its value in preventing recurrence.
authors.affiliation: Laboratório de Investigação Médica/Patologia das Moléstias Infecciosas, Hospital das Clínicas e Departamentos de Doenças Infecciosas e Parasitárias, Otorrino-Laringologia da Faculdade de Medicina da Universidade de São Paulo.
authors.forename: V S
authors.initials: VS
authors.lastname: Amato
authors.forename: J G
authors.initials: JG
authors.lastname: de Paula
authors.forename: R
authors.initials: R
authors.lastname: Imamura
authors.forename: V
authors.initials: V
authors.lastname: Amato Neto
authors.forename: M I
authors.initials: MI
authors.lastname: Duarte
authors.forename: M I
authors.initials: MI
authors.lastname: Boulos
authors.forename: M
authors.initials: M
authors.lastname: Boulos
authors.forename: A C
authors.initials: AC
authors.lastname: Nicodemo
authors.forename: J S
authors.initials: JS
authors.lastname: de Mendonca
mesh_terms: D000368:Aged; D000981:Antiprotozoal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D010419:Pentamidine / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000981:Antiprotozoal Agents; D010419:Pentamidine
vernacular_title: Tratamento da leishmaniose tegumentar americana, com lesão em mucosa, por meio do isotionato de pentamidina.