title: Coumadin: principles of use.
abstract: Numerous clinical trials have been performed to identify the optimal therapeutic range for various indications in patients receiving warfarin. Other studies have identified risk factors for hemorrhage and thromboembolism to decrease the risk of these complications. A more consistent approach, using guidelines presented in this article, toward initiation, monitoring, and reversal of anticoagulation should further decrease the incidence of complications.
authors.affiliation: Department of Surgery, University of Missouri-Columbia 65212, USA.
authors.forename: T K
authors.initials: TK
authors.lastname: Liem
authors.forename: D
authors.initials: D
authors.lastname: Silver
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use*; D004347:Drug Interactions; D006350:Heart Valve Prosthesis; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D013927:Thrombosis / Q000188:drug therapy; D014812:Vitamin K / Q000502:physiology; D014859:Warfarin / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000925:Anticoagulants; D014812:Vitamin K; D014859:Warfarin; D006493:Heparin