title: No increased prevalence of adrenocortical insufficiency in human immunodeficiency virus-associated tuberculosis.
abstract: METHODS
  Acute medical wards, Kenyatta National Hospital, Nairobi, Kenya.
  
  
  OBJECTIVE
  To determine the prevalence of adrenocortical insufficiency in human immunodeficiency virus (HIV)-1 infected and non-infected patients with tuberculosis.
  
  
  METHODS
  One hundred and seventy-four patients with proven tuberculosis (90 HIV-1 positive and 84 HIV-1 negative) were assessed for adrenocortical insufficiency with a 30 min synacthen stimulation test.
  
  
  RESULTS
  Fifty-one percent of those with pulmonary tuberculosis and 56% of those with extra-pulmonary tuberculosis had a subnormal cortisol response. However there was no statistically significant difference between the HIV-1 infected and non-infected patients in either group.
  
  
  CONCLUSIONS
  While an impaired cortisol response is common in tuberculosis, it is no more prevalent in HIV-1 infected patients than non-infected patients with tuberculosis.
authors.affiliation: Clinical Research Centre, Kenya Medical Research Institute, Nairobi, Kenya.
authors.forename: M P
authors.initials: MP
authors.lastname: Hawken
authors.forename: J C
authors.initials: JC
authors.lastname: Ojoo
authors.forename: J S
authors.initials: JS
authors.lastname: Morris
authors.forename: E W
authors.initials: EW
authors.lastname: Kariuki
authors.forename: W A
authors.initials: WA
authors.lastname: Githui
authors.forename: E S
authors.initials: ES
authors.lastname: Juma
authors.forename: S N
authors.initials: SN
authors.lastname: Gathua
authors.forename: J N
authors.initials: JN
authors.lastname: Kimari
authors.forename: L N
authors.initials: LN
authors.lastname: Thiong'o
authors.forename: J G
authors.initials: JG
authors.lastname: Raynes
authors.forename: P
authors.initials: P
authors.lastname: Broadbent
authors.forename: C F
authors.initials: CF
authors.lastname: Gilks
authors.forename: L S
authors.initials: LS
authors.lastname: Otieno
authors.forename: K P
authors.initials: KP
authors.lastname: McAdam
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000097:blood / Q000503:physiopathology*; D000293:Adolescent; D000311:Adrenal Glands / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015497:HIV-1; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D014376:Tuberculosis / Q000097:blood / Q000503:physiopathology*; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000503:physiopathology
chemical_list: D006854:Hydrocortisone