[Na/Ca exchange].
Na/Ca exchange is an important regulatory mechanism of the cytosolic free Ca2+ concentration in most cells. This transporter, localized at the level of the plasma membrane, represents with the plasma membrane Ca2+ ATPase, one of the two systems allowing active Ca2+ extrusion from the cells. Renewed interest for this system comes from recent advances in the molecular biology of the exchanger and the identification of the major role played by the exchanger in Ca2+ extrusion from cardiac cells. These recent progresses may allow a better understanding of the role played by Na/Ca in Physiology and in Physiopathology, e.g. in cardiac ischemia.
Herchuelz
A
A
Laboratoire de Pharmacodynamie et de Thérapeutique, faculté de Médecine, Université libre de Bruxelles.
D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D006801:Humans; D017136:Ion Transport; D009206:Myocardium / Q000166:cytology / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*
D012964:Sodium; D000252:Calcium-Transporting ATPases; D002118:Calcium
L'echange Na/Ca.