[A case of renal transplantation from an ABO-incompatible donor successfully pretreated with double filtration plasmapheresis].
A 40-year-old female, whose blood type was A, Rh+, was admitted to our hospital for kidney transplantation from her younger brother whose blood type was B, Rh+. Before the transplantation, we performed 4 sessions of double filtration plasmapheresis (DFPP) to remove the anti-B antibodies. The serum anti-B antibody titer lowered from X32 to X4. The kidney transplantation was carried out following the splenectomy. The warm ischemic time was 8 minutes and the cold ischemic time was 47 minutes. Five immuno-suppressive agents including cyclospolin, azathioprine, prednisolone, anti-lymphocyte globulin (ALG), and deoxyspergualin were administered in the initial period. Nine days after the transplantation, an acute rejection occurred, and 15 sessions of hemodialysis were needed. However, Methylprednisolone and OKT3 treatment resulted in recovery of the graft function. Seventy-four days after the transplantation, she was discharged with the serum creatinine concentration of 1.3 mg/dl. The DFPP before transplantation was useful to remove the anti-RBC antibody from the patient receiving an ABO incompatible kidney allograft.
Hirano
Y
Y
Department of Urology, Hamamatsu University School of Medicine.
Ohira
T
T
Ishikawa
A
A
Ushiyama
T
T
Suzuki
K
K
Fujita
K
K
D000017:ABO Blood-Group System; D000328:Adult; D001787:Blood Group Incompatibility / Q000628:therapy*; D005260:Female; D005374:Filtration; D006801:Humans; D016030:Kidney Transplantation; D010956:Plasmapheresis / Q000379:methods*; D011300:Preoperative Care; D014019:Tissue Donors
D000017:ABO Blood-Group System