title: A nuclear RNA-binding cyclophilin in human T cells.
abstract: Cyclophilins (CyPs) are binding proteins for the immunosuppressive drug cyclosporin A (CsA). CyPs are evolutionarily highly conserved proteins present in both pro- and eukaryotes as well as in different subcellular locations. CyPs possess enzymatic activity, namely peptidyl-prolyl cis-trans isomerase (PPIase) activity; CyPs are involved in cellular protein folding and protein interactions. To date, only cyclosporins and proteins are known to interact with CyPs. Here we describe a novel nuclear cyclophilin (hCyP33) from human T cells with an additional RNA-binding domain. This combines for the first time RNA binding and protein folding in one protein.
authors.affiliation: Institut für Biochemie und Molekularbiologie der Albert-Ludwigs-Universität, Freiburg, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Mi
authors.forename: O
authors.initials: O
authors.lastname: Kops
authors.forename: E
authors.initials: E
authors.lastname: Zimmermann
authors.forename: A
authors.initials: A
authors.lastname: Jäschke
authors.forename: M
authors.initials: M
authors.lastname: Tropschug
mesh_terms: D000591:Amino Acid Isomerases / Q000737:chemistry* / Q000378:metabolism; D000595:Amino Acid Sequence; D002352:Carrier Proteins / Q000737:chemistry* / Q000378:metabolism; D003001:Cloning, Molecular; D021983:Cyclophilins; D018076:DNA, Complementary; D006801:Humans; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000737:chemistry* / Q000378:metabolism; D019696:Peptidylprolyl Isomerase; D017510:Protein Folding; D012313:RNA / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000378:metabolism; D016415:Sequence Alignment; D013601:T-Lymphocytes / Q000737:chemistry*
chemical_list: D002352:Carrier Proteins; D018076:DNA, Complementary; D009687:Nuclear Proteins; D016601:RNA-Binding Proteins; D011993:Recombinant Fusion Proteins; D012313:RNA; D000591:Amino Acid Isomerases; D021983:Cyclophilins; C114522:PPIE protein, human; D019696:Peptidylprolyl Isomerase