Xenotransplantation: from animal facility to the clinic?
Since 1960, clinical organ transplantation has evolved from an experimental procedure to highly successful 'routine', but as technical advances have extended eligibility to more victims of end-stage organ disease, the supply of donor organs has lagged behind. Urgency of need, probability of success and ability to pay are often used to limit waiting lists; without these, as many as 124,000 transplants per year could be performed in the USA alone. Although the supply of organs from human donors may well be assisted in future by increased public education and changes in donor laws, it is unlikely that the need for organs will ever be met by generosity and calamity alone-hence the enthusiasm for other sources of organs.
Rowe
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D000818:Animals; D005544:Forecasting; D006801:Humans; D007108:Immune Tolerance; D007165:Immunosuppression Therapy; D012059:Rejection, Psychology; D013552:Swine; D014183:Transplantation, Heterologous / Q000009:adverse effects / Q000276:immunology* / Q000379:methods; D015047:Zoonoses