title: Fourier transform ion cyclotron resonance mass spectrometry in a 20 T resistive magnet.
abstract: We present Fourier transform ion cyclotron resonance (FTICR) mass spectra at a magnetic field of 20 T; more than twice the highest field previously used for FTICR. Our instrument is based on a resistive magnet installed at the National High Magnetic Field Laboratory. The magnet has a 50 mm diameter bore and spatial inhomogeneity of approximately 1000 ppm over a 1 cm diameter spherical volume. However, FTICR mass resolving power far in excess of magnet homogeneity is achieved routinely for ions produced by either electron ionization (EI) or matrix-assisted laser desorption/ionization (MALDI). As examples, we show a MALDI mass spectrum of [M + H] quasimolecular ions of the peptide, human luteinizing hormone-releasing hormone (monoisotopic molecular weight, 1181.6 Da) at mass resolving power, m/delta m > 10,000; and an EI mass spectrum of molecular ions of the platinum cluster compound, Pt4(PF3)8 (average molecular weight, 1484 Da at mass resolving power, m/delta m approximately 20,000. Much better FTICR MS performance is predicted for future NHMFL resistive magnets of higher spatial and temporal homogeneity.
authors.affiliation: Center for Interdisciplinary Magnetic Resonance, National High Magnetic Field Laboratory, Florida State University, Tallahassee 32310, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Hendrickson
authors.forename: J J
authors.initials: JJ
authors.lastname: Drader
authors.forename: D A
authors.initials: DA
authors.lastname: Laude
authors.forename: S
authors.initials: S
authors.lastname: Guan
authors.forename: A G
authors.initials: AG
authors.lastname: Marshall
mesh_terms: D017357:Cyclotrons; D055590:Electromagnetic Phenomena; D005583:Fourier Analysis; D007987:Gonadotropin-Releasing Hormone / Q000737:chemistry; D006801:Humans; D013058:Mass Spectrometry / Q000295:instrumentation*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D007987:Gonadotropin-Releasing Hormone