Tumor angiogenesis and expression of thymidine phosphorylase/platelet derived endothelial cell growth factor in human gastric carcinoma.
To investigate the relationship between tumor angiogenesis and the expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/dThdPase) and between patients' survival and the expression of PD-ECGF/ dThdPase in human gastric carcinoma tissues, we performed immunohistochemical studies with anti-PD-ECGF/dThdPase and anti-CD34 monoclonal antibodies. Out of 154 gastric carcinoma tissue samples, 61 (40%) were evaluated as PD-ECGF/ dThdPase-positive. The expression of PD-ECGF/dThdPase was significantly associated with the intratumoral microvessel counts (P < 0.0001) and the incidence of hematogenous metastasis (P < 0.05). Intratumoral vessel counts were significantly correlated with overall survival of 154 patients (P < 0.000001). Cox proportional hazards model showed that tumor vasculature was an independent and strong prognostic variable. However, the prevalence of the expression of PD-ECGF did not associate the overall survival. We suggest that expression of PD-ECGF/dThdPase plays a role in the promotion of angiogenesis in human gastric carcinomas, without any definite influence on patient's survival.
Tanigawa
N
N
Second Department of Surgery, Fukui Medical School, Japan.
Amaya
H
H
Matsumura
M
M
Katoh
Y
Y
Kitaoka
A
A
Aotake
T
T
Shimomatsuya
T
T
Rosenwasser
O A
OA
Iki
M
M
D000230:Adenocarcinoma / Q000098:blood supply / Q000201:enzymology*; D000368:Aged; D015153:Blotting, Western; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D010982:Platelet-Derived Growth Factor / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000098:blood supply / Q000201:enzymology*; D016019:Survival Analysis; D013939:Thymidine Phosphorylase / Q000378:metabolism*
D010982:Platelet-Derived Growth Factor; D013939:Thymidine Phosphorylase