Asthmatic reactions after nasal allergen provocation.
Three bronchoconstrictive responses associated with acute rhinitis and occurring in two patients were observed among 400 nasal allergen challenges. Causative substances were birch pollen, Dermatophagoides pteronyssinus and HSA-conjugated pyromellitic dianhydride. Both subjects showed bronchial hyperreactivity and immediate-type sensitization to these allergens. It is concluded that bronchoobstruction nearly occurs in nasal allergen challenges. The underline pathophysiological mechanism remains unclear.
Baur
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Medical Department, Ruhr University of Bochum, Germany.
D000208:Acute Disease; D000328:Adult; D000485:Allergens / Q000276:immunology*; D039741:Antigens, Dermatophagoides; D001249:Asthma / Q000276:immunology*; D001565:Benzoates / Q000276:immunology; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D008297:Male; D009299:Nasal Provocation Tests / Q000009:adverse effects*; D011058:Pollen / Q000276:immunology; D012220:Rhinitis / Q000276:immunology; D012709:Serum Albumin / Q000276:immunology; D014197:Trees / Q000276:immunology
D000485:Allergens; D039741:Antigens, Dermatophagoides; D001565:Benzoates; D006023:Glycoproteins; D012709:Serum Albumin; C012019:pyromellitic dianhydride