title: Apoptosis and T-cell depletion during feline infectious peritonitis.
abstract: Cats that have succumbed to feline infectious peritonitis, an immune-mediated disease caused by variants of feline coronaviruses, show apoptosis and T-cell depletion in their lymphoid organs. The ascitic fluid that develops in the course of the condition causes apoptosis in vitro but only in activated T cells. Since feline infectious peritonitis virus does not infect T cells, and viral proteins did not inhibit T-cell proliferation, we postulate that soluble mediators released during the infection cause apoptosis and T-cell depletion.
authors.affiliation: Department of Infectious Diseases and Immunology, Veterinary Faculty, Utrecht University, The Netherlands. B.Haagmans@vetmic.dgk.ruu.nl
authors.forename: B L
authors.initials: BL
authors.lastname: Haagmans
authors.forename: H F
authors.initials: HF
authors.lastname: Egberink
authors.forename: M C
authors.initials: MC
authors.lastname: Horzinek
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001202:Ascitic Fluid / Q000276:immunology; D017252:CD3 Complex / Q000032:analysis; D002415:Cats; D002455:Cell Division; D002478:Cells, Cultured; D016765:Coronavirus, Feline / Q000276:immunology*; D016766:Feline Infectious Peritonitis / Q000276:immunology*; D006801:Humans; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D008212:Lymphocyte Depletion; D008643:Mesentery / Q000166:cytology / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology
chemical_list: D017252:CD3 Complex