[Reduced concentration of insulin-like growth factor I in patients with cystic fibrosis].
Cystic fibrosis is frequently accompanied by a catabolic condition with low body mass index caused by a number of disease complications. Insulin-like growth factor I (IGF-I) is an anabolic hormone and an important marker of nutritional status, liver function and linear growth. Using radioimmunoassay we measured IGF-I once in 235 of our 240 patients (114 males, 121 females, median age 16.2 years, range 0.1-44.0 years). IGF-I was significantly reduced compared with a healthy Scandinavian control population: Mean (-2SD to +2SD) IGF-I-SD score -0.97 (-3.7 to 1.7) in males and -0.67 (-3.2 to 1.9) in females, both values were significantly different from zero (p < 0.001). Height SD score was -0.95 (-3.3 to 1.4) in males and -0.81 (-3.2 to 1.6) in females (p < 0.001). The low IGF-I concentrations may reflect the catabolic state of many patients with cystic fibrosis and play a part in their abnormal growth pattern.
Laursen
E M
EM
Afdeling for vaekst og reprodukion, GR-5064, Rigshospitalet, København.
Juul
A
A
Thorsteinsson
S L
SL
Høiby
N
N
Koch
C
C
Müller
J R
JR
Skakkebaek
N E
NE
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D013002:Somatomedins / Q000032:analysis*
D013002:Somatomedins; D007334:Insulin-Like Growth Factor I
Nedsatte koncentrationer af insulin-like growth factor I hos patienter med cystisk fibrose.