Epidermal remodelling in psoriasis.
Psoriatic hyperproliferative epidermis is characterized by a regular elongation of rete ridges, accompanied by altered keratinization. Another notable finding is close positioning of the vasculature to the suprapapillary epidermis. These architectural/morphological changes are naturally described by a concept of epidermal remodelling based on decreased epidermal turnover time. The recently described positioning of stem cells to the tips of dermal papillae fits nicely with this concept.
Iizuka
H
H
Department of Dermatology, Asahikawa Medical College, Japan.
Ishida-Yamamoto
A
A
Honda
H
H
D002455:Cell Division; D004817:Epidermis / Q000473:pathology*; D006801:Humans; D015603:Keratinocytes / Q000473:pathology; D007633:Keratins / Q000378:metabolism; D008954:Models, Biological; D011565:Psoriasis / Q000378:metabolism / Q000473:pathology*; D012039:Regional Blood Flow; D013234:Stem Cells / Q000473:pathology
D007633:Keratins