Presence of norepinephrine and other biogenic amines in stonefish venom.
Although fish venoms exert a cardiovascular effect, the presence of adrenergic substances was not previously demonstrated. Chromatographic analysis with electrochemical detection showed the presence of substances co-migrating with norepinephrine, dopamine and tryptophan. Serotonin, which was thought to be implicated in the intense pain following fish envenomation, was not detected. Norepinephrine was identified as a component of the stonefish Synanceia verrucosa venom by gas chromatography-mass spectrometry.
Garnier
P
P
Laboratoire de Biologie et Contrôle des Organismes Parasites, Université de Paris-Sud, Châtenay-Malabry, France.
Grosclaude
J M
JM
Goudey-Perrière
F
F
Gervat
V
V
Gayral
P
P
Jacquot
C
C
Perrière
C
C
D000316:Adrenergic alpha-Agonists / Q000032:analysis* / Q000737:chemistry; D000818:Animals; D001679:Biogenic Amines / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004298:Dopamine / Q000032:analysis; D004563:Electrochemistry; D005397:Fish Venoms / Q000737:chemistry*; D005400:Fishes, Poisonous; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D009638:Norepinephrine / Q000032:analysis* / Q000737:chemistry; D014364:Tryptophan / Q000032:analysis
D000316:Adrenergic alpha-Agonists; D001679:Biogenic Amines; D005397:Fish Venoms; D014364:Tryptophan; D004298:Dopamine; D009638:Norepinephrine