title: Impact of systemic depulsation on tissue perfusion and sympathetic nerve activity.
abstract: BACKGROUND
  We postulated that pathophysiologic processes under nonpulsatile circulation are related to the behavior of the sympathetic nerve activity that regulates tissue perfusion.
  
  
  METHODS
  Pulsatile and nonpulsatile pumps were installed in parallel in the left heart bypass circuit of anesthetized goats (n = 9) so that pulsatile circulation could be converted to nonpulsatile circulation instantly. At 5 minutes before and after systemic depulsation, we measured hemodynamic indices, renal nerve activity, and regional blood flow of the brain, heart, and renal cortex.
  
  
  RESULTS
  Renal nerve activity was significantly elevated after systemic depulsation (15.6 +/- 9.3 versus 19.4 +/- 9.8 microV), when mean aortic pressure remained almost constant. The renal cortical flow was significantly reduced after depulsation (3.61 +/- 1.23 versus 2.93 +/- 1.19 mL.min-1.g-1), whereas no significant difference was found in the regional blood flow of the brain or the heart.
  
  
  CONCLUSIONS
  The significant reduction of renal cortical blood flow after systemic depulsation is associated with a significant increase in renal nerve activity. Our results suggest that increased renal nerve activity plays an important role in the reduction of renal function after systemic depulsation.
authors.affiliation: Department of Artificial Organs, National Cardiovascular Center Research Institute, Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Toda
authors.forename: E
authors.initials: E
authors.lastname: Tatsumi
authors.forename: Y
authors.initials: Y
authors.lastname: Taenaka
authors.forename: T
authors.initials: T
authors.lastname: Masuzawa
authors.forename: H
authors.initials: H
authors.lastname: Takano
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D002315:Cardiopulmonary Bypass; D002560:Cerebrovascular Circulation; D003326:Coronary Circulation; D006041:Goats; D006439:Hemodynamics; D007668:Kidney / Q000294:innervation*; D007672:Kidney Cortex / Q000098:blood supply; D011673:Pulsatile Flow; D012079:Renal Circulation; D013564:Sympathetic Nervous System / Q000502:physiology*