Proinflammatory and anti-inflammatory cytokines in meningococcal disease.
Interleukin-10 (IL-10), an anti-inflammatory cytokine, was measured in 131 children with meningococcal disease. IL-10 concentrations were significantly higher in children who died and correlated positively with proinflammatory cytokines. Children who die from meningococcal disease have high IL-10 concentrations, which do not suppress proinflammatory cytokines.
Riordan
F A
FA
Institute of Child Health, University of Liverpool.
Marzouk
O
O
Thomson
A P
AP
Sills
J A
JA
Hart
C A
CA
D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D008589:Meningococcal Infections / Q000276:immunology*; D011446:Prospective Studies; D012772:Shock, Septic / Q000276:immunology; D015996:Survival Rate; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D015415:Biomarkers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10