Cosegregation of the new region on chromosome 3 with salt-induced hypertension in female F2 progeny from stroke-prone spontaneously hypertensive and Wistar-Kyoto rats.
1. We investigated candidate loci for salt-sensitive high blood pressure (BP) in F2 progeny from crossing Wistar-Kyoto and stroke-prone spontaneously hypertensive rats. 2. In female F2 progeny, systolic and diastolic BP on the 12th day and the seventh month after salt loading was strongly linked with the D3Mgh12 and D3Mgh6 loci on chromosome 3, respectively. 3. These loci were linked with BP only in female F2 progeny, not in males. 4. These results indicate that hormonal factors may influence salt sensitivity, particularly with respect to gender differences.
Matsumoto
C
C
Department of Life Science, Graduate School of Human and Environmental Studies, Kyoto University, Japan.
Nara
Y
Y
Ikeda
K
K
Tamada
T
T
Mashimo
T
T
Nabika
T
T
Sawamura
M
M
Yamori
Y
Y
D000818:Animals; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000235:genetics*; D003433:Crosses, Genetic; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000235:genetics*; D008540:Meiosis; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012965:Sodium Chloride
D005819:Genetic Markers; D012965:Sodium Chloride