Synthesis, structures and biological activity of some N1-substituted 4-oxocinnolines.
The method of preparation of N1-substituted 4-hydroxycinnolines is described, by alkylation with methyl bromopropionate of the corresponding 4-hydroxycinnolines. The obtained esters were further converted into amides and hydrazides. The effect of several synthesized derivatives on central nervous system was studied. The structure of some of them was confirmed by the X-ray analysis.
Stańczak
A
A
Department of Pharmaceutical Chemistry and Drug Analysis, Faculty of Pharmacy, School of Medicine, Lódź, Poland.
Kwapiszewski
W
W
Ochocki
Z
Z
Lewgowd
W
W
Szadowska
A
A
Pakulska
W
W
Główka
M L
ML
D000818:Animals; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003461:Crystallography; D005260:Female; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D002491:Central Nervous System Agents