title: Changes in calcium handling in atrophic heterotopically isotransplanted rat hearts.
abstract: Atrophy of the rat heart induced by hemodynamic unloading after heterotopic transplantation is associated with impaired relaxation while systolic function remains normal when compared to the heart of the recipient animal. To identify possible underlying mechanisms for the above, we studied some aspects of membrane calcium handling using postextrasystolic potentiation of contractions in the isolated right ventricular papillary muscle and in the left ventricle of the Langendorff-perfused heart. We also compared the alterations of the unloaded heart with those of overloaded hypertrophic hearts of rats with suprarenal aortic constriction. In the atrophic heart the degree of potentiation after one extrasystole, considered to be proportional to the trans-sarcolemmal influx of Ca2+ during an action potential, was increased by 125% when compared with recipient hearts. The rate of decay of potentiation which reflects the fraction of activator Ca2+ recirculating in the cells via the sarcoplasmic reticulum, negatively correlated with the degree of potentiation, although its mean value was not significantly altered. In hypertrophic hearts the decay of potentiation was faster when compared with the hearts of sham-operated animals, indicating a decreased recirculating fraction of Ca2+ The data suggest that the relative importance of trans-sarcolemmal Ca2+ fluxes is increased both in cardiac atrophy and hypertrophy; but their quantitative role in the control of cardiac contraction might differ.
authors.affiliation: Department of Developmental Cardiology, Academy of Sciences of the Czech Republic.
authors.forename: F
authors.initials: F
authors.lastname: Kolár
authors.forename: C
authors.initials: C
authors.lastname: MacNaughton
authors.forename: F
authors.initials: F
authors.lastname: Papousek
authors.forename: B
authors.initials: B
authors.lastname: Korecky
authors.forename: K
authors.initials: K
authors.lastname: Rakusan
mesh_terms: D000818:Animals; D001284:Atrophy / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism*; D016027:Heart Transplantation / Q000502:physiology*; D006352:Heart Ventricles / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009929:Organ Size; D051381:Rats; D016042:Transplantation, Heterotopic
chemical_list: D002118:Calcium