title: [Acute interstitial nephropathy induced by vancomycin].
abstract: The authors report a case of tubulo-interstitial nephritis with acute renal failure due to vancomycin used to treat a patient with enterococcus endocarditis. Rechallenge with vancomycin several days after stopping the drug resulted in the appearance of a maculopapular rash and rapid onset of acute oligo-anuric renal failure. Renal biopsy revealed acute interstitial nephritis. This feature is suggestive of cellular mediated hypersensitivity.
authors.affiliation: Service de néphrologie, Centre hospitalier général, Dunkerque.
authors.forename: R
authors.initials: R
authors.lastname: Azar
authors.forename: E
authors.initials: E
authors.lastname: Bakhache
authors.forename: A
authors.initials: A
authors.lastname: Boldron
mesh_terms: D000208:Acute Disease; D058186:Acute Kidney Injury / Q000139:chemically induced; D000368:Aged; D004697:Endocarditis, Bacterial / Q000188:drug therapy; D016983:Enterococcus; D005260:Female; D006801:Humans; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology; D014640:Vancomycin / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D014640:Vancomycin
vernacular_title: Néphropathie interstitielle aiguë induite par la vancomycine.