title: Quantitative EEG in long-term survivors of acute lymphoblastic leukemia.
abstract: Conventional and quantitative aspects of electroencephalographic recordings obtained during a follow-up surveillance study in long-term survivors of acute lymphoblastic leukemia in childhood were investigated with respect to differences in central nervous system prophylaxis given during antileukemic therapy and compared with data derived from healthy controls. Central nervous system prophylaxis consisted either of cranial irradiation (18 Gray, group A, n = 8) or intermediate high-dose methotrexate (2000 mg/m2; group B, n = 5), each combined with intrathecal methotrexate. Conventional electroencephalographic analysis revealed comparable results in all three study groups. However, quantitative electroencephalography showed significantly increased absolute power scores for all frequency bands in both long-term survivor groups. Relative power estimates revealed a significant increase in delta/tau activities in both prophylaxis groups compared to healthy controls, which were countered by decreased percentage power scores in the alpha-range. Quantitative electroencephalographic comparisons between both central nervous system prophylaxis groups revealed only small differences in quantity, not quality, of the observed power disturbances with slightly higher deviations in irradiated long-term survivors than in nonirradiated ones. Topographical distributions of spectral band power were comparable between all three study groups without evidence for therapy-related topographical differences.
authors.affiliation: Neuropediatric Department, University Hospital for Children and Adolescents, Erlangen, Germany.
authors.forename: M A
authors.initials: MA
authors.lastname: Ueberall
authors.forename: K
authors.initials: K
authors.lastname: Haupt
authors.forename: H
authors.initials: H
authors.lastname: Hertzberg
authors.forename: T
authors.initials: T
authors.lastname: Langer
authors.forename: W
authors.initials: W
authors.lastname: Meier
authors.forename: W J
authors.initials: WJ
authors.lastname: Huk
authors.forename: J D
authors.initials: JD
authors.lastname: Beck
authors.forename: D
authors.initials: D
authors.lastname: Wenzel
mesh_terms: D000293:Adolescent; D000328:Adult; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology / Q000528:radiation effects; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects / Q000528:radiation effects / Q000706:statistics & numerical data*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000503:physiopathology* / Q000532:radiotherapy; D012815:Signal Processing, Computer-Assisted
chemical_list: D008727:Methotrexate