title: Taenia saginata: vaccination against cysticercosis in cattle with recombinant oncosphere antigens.
abstract: Taenia saginata is a medically and economically important cestode parasite. Infection with the cysticercus larval stage in cattle causes economic loss in the beef meat industry. A practical vaccine to prevent infection with the parasite in cattle would be valuable and would assist in control of transmission of the parasite to humans, the obligate definitive host. Here we use recombinant DNA techniques to clone oncosphere antigens of T. saginata and use the recombinant antigens in vaccine trials in cattle. Vaccination with a combination of two antigens, designated TSA-9 and TSA-18, induced up to 99.8% protection against experimental challenge infection with T. saginata eggs. Operational characteristics of the vaccine will need to be defined, such as duration of immunity and protection of newborn calves. The vaccine has the potential to be used on a commercial scale for the control of bovine cysticercosis.
authors.affiliation: Molecular Parasitology Laboratory, University of Melbourne, Werribee, Victoria, Australia.
authors.forename: M W
authors.initials: MW
authors.lastname: Lightowlers
authors.forename: R
authors.initials: R
authors.lastname: Rolfe
authors.forename: C G
authors.initials: CG
authors.lastname: Gauci
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000947:Antigens, Helminth / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D003551:Cysticercosis / Q000517:prevention & control / Q000662:veterinary*; D003552:Cysticercus / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D014611:Vaccination / Q000662:veterinary*; D019444:Vaccines, DNA
chemical_list: D000947:Antigens, Helminth; D019444:Vaccines, DNA