[Analysis of polymorphism of the 5'-terminal region of apolipoprotein B gene in patients with ischemic heard disease].
Comparative analysis of polymorphism of two polymorphic regions in the 5'-end of the apolipoprotein B gene-insertion/ deletion polymorphism of a signal peptide of apo B and microsatellite (CA)n repeat-was performed in a random sample of men from the Moscow population aged 49-51 and in heart patients. No associations among the gene polymorphic regions, development of coronary heart disease, and certain changes in the lipid spectrum of plasma are revealed. This indicates that the structural organization of the 5'-region of apolipoprotein gene B (Moscow population) has no substantial role in determining the risk of coronary heart disease.
Shadrina
M I
MI
Slonimskiĭ
P A
PA
Oganov
R G
RG
Perova
N V
NV
Limborskaia
S A
SA
D000328:Adult; D001055:Apolipoproteins B / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D017202:Myocardial Ischemia / Q000097:blood / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D021382:Protein Sorting Signals / Q000235:genetics; D017384:Sequence Deletion
D001055:Apolipoproteins B; D021382:Protein Sorting Signals
Analiz polimorfizma 5'-kontsevoĭ oblasti gena apolipoproteina B u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.