Posttransplant lymphoproliferative disease after cardiac transplantation. Two unusual variants with predominantly plasmacytoid features.
Two patients who developed posttransplant lymphoproliferative disorder with plasmacytoid changes in the lymphocytes after heart transplant are described. The first case is one of multiple myeloma, and the second is a case of lymphoma with plasmacytoid features. The clinical course and the etiologic role of the immunosuppressive therapies that the patients received for heart transplantation are described. A review of posttransplant multiple myeloma and discussion of the etiology and prognosis of this entity are presented.
Fischer
T
T
Department of Hematology, Cleveland Clinic Foundation, Ohio 44195, USA.
Miller
M
M
Bott-Silverman
C
C
Lichtin
A
A
D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D006965:Hyperplasia / Q000150:complications / Q000209:etiology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000209:etiology; D008232:Lymphoproliferative Disorders / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000209:etiology; D010950:Plasma Cells / Q000473:pathology; D015996:Survival Rate