title: Erythrocyte Li-Na countertransport in uremic patients: effect of urea.
abstract: Abnormalities of erythrocyte cation transport systems including Li-Na countertransport have been described in uremic patients. Dialysis appears to eliminate the difference in some of the patients. We investigated the rate of Li-Na countertransport from erythrocytes of normal healthy subjects and uremic patients undergoing hemodialysis treatment. We found that erythrocytes from uremic patients exhibited a significantly elevated rate of Li-Na countertransport. Furthermore, urea (30 mM) did not affect the rate of Li-Na countertransport or the electrolyte contents for Li loaded erythrocytes. Our findings showed that while both plasma and urea concentration and erythrocyte Li-Na countertransport were elevated in uremic patients, urea was not the major cause of the enhanced activity of the transporter.
authors.affiliation: Foo Yin Junior College of Nursing and Medical Technology, Kaohsiung, R.O.C.
authors.forename: Y F
authors.initials: YF
authors.lastname: Sun
authors.forename: C J
authors.initials: CJ
authors.lastname: Tsai
authors.forename: C C
authors.initials: CC
authors.lastname: Hsieh
authors.forename: Y T
authors.initials: YT
authors.lastname: Lau
mesh_terms: D000328:Adult; D017920:Antiporters / Q000378:metabolism*; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D012016:Reference Values; D006435:Renal Dialysis; D014508:Urea / Q000494:pharmacology*; D014511:Uremia / Q000097:blood* / Q000628:therapy
chemical_list: D017920:Antiporters; C045885:sodium-lithium countertransporter; D014508:Urea