What causes ion channel proteins to fluctuate open and closed?
Ion channels in the cell membrane spontaneously switch from states that are closed to the flow of ions such as sodium, potassium, and chloride to states that are open to the flow of these ions. The durations of times that an individual ion channel protein spends in the closed and open states can be measured by the patch clamp technique. We explore two basic issues about the molecular properties of ion channels: 1) If the switching between the closed and open state is an inherently random event, what does the patch clamp data tell us about the structure or motions in the ion channel protein? 2) Is this switching random?
Liebovitch
L S
LS
Center for Complex Systems, Florida Atlantic University, Boca Raton 33431, USA. liebovitch@walt.ccs.fau.edu
Todorov
A T
AT
D000818:Animals; D007473:Ion Channels / Q000378:metabolism*; D008390:Markov Chains; D008565:Membrane Proteins / Q000737:chemistry*; D009038:Motion; D018408:Patch-Clamp Techniques; D011487:Protein Conformation
D007473:Ion Channels; D008565:Membrane Proteins