Activation of NMDA and muscarinic receptors induces nur-77 mRNA in hippocampal neurons.
Using in situ hybridization, we show that the expression of the immediately-early gene, nur-77, increases rapidly and transiently in hippocampal neurons following activation of muscarinic and N-methyl-D-aspartate receptors and after hippocampal long-term potentiation (LTP). On the basis of these results we hypothesize that nur-77 may coordinate with other transcription factors to initiate subsequent changes in hippocampal gene expression associated with plasticity-related activation of N-methyl-D-aspartate and muscarinic receptors.
Dragunow
M
M
Department of Pharmacology and Clinical Pharmacology, School of Medicine, University of Auckland, New Zealand.
Abraham
W
W
Hughes
P
P
D000818:Animals; D001345:Autoradiography; D003513:Cycloheximide / Q000494:pharmacology; D006624:Hippocampus / Q000378:metabolism*; D017403:In Situ Hybridization; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D011976:Receptors, Muscarinic / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D013997:Time Factors
D012333:RNA, Messenger; D011976:Receptors, Muscarinic; D016194:Receptors, N-Methyl-D-Aspartate; D003513:Cycloheximide