title: Activity of liver cytochrome P-450-dependent monooxygenase system in morphine-dependent rats.
abstract: Young female Wistar rats were injected intraperitoneally with increasing doses of morphine (9-45 mg/kg b.w. twice a day) for 14 days. The activities of the cytochrome P-450-dependent monooxygenase system and microsomal electron transport chain I were determined. Long-term morphine treatment decreased significantly cytochrome P-450 content, while it did not affect microsomal electron transport chain I. A decrease in cytochrome b5 content was accompanied by a compensatory increase in the activity of NADH-cytochrome b5 reductase. Both 4-aminopyrine N-demethylase activity and aniline hydroxylase activity decreased after morphine treatment (48% and 70%, respectively, when compared with controls).
authors.affiliation: 2nd Department of Histology and Embryology, Silesian School of Medicine, Katowice-Ligota, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Glogowska-Szelag
authors.forename: A
authors.initials: A
authors.lastname: Plewka
authors.forename: M
authors.initials: M
authors.lastname: Kamiński
authors.forename: J
authors.initials: J
authors.lastname: Górski
authors.forename: D
authors.initials: D
authors.lastname: Kajdaniuk
authors.forename: M
authors.initials: M
authors.lastname: Nowak
authors.forename: B
authors.initials: B
authors.lastname: Buntner
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005260:Female; D008099:Liver / Q000201:enzymology* / Q000473:pathology; D009021:Morphine Dependence; D051381:Rats
chemical_list: D003577:Cytochrome P-450 Enzyme System