title: Fast neutron therapy for inoperable or recurrent sacrococcygeal chordomas.
abstract: Between 1981 and 1994, 13 patients were referred to the Orleans neutrontherapy department with inoperable or recurrent pelvic chordomas. One patient who had already been irradiated refused the treatment, fearing complications. Among the 12 patients suitable for evaluation, ten had undergone one to five previous surgical operations. The time lapse between the last surgical operation and neutrontherapy was 13 months. Neutrons were used alone or as a boost depending on the tumor volume or treatment purpose. At four years, crude survival and local control probability (Kaplan-Meier) were 61 and 54% respectively. This small series suggests that fast neutrontherapy can provide a good alternative for the treatment of inoperable sacral chordomas.
authors.affiliation: CHR Service d'Oncologie et de Radiothérapie, Orléans, France.
authors.forename: N
authors.initials: N
authors.lastname: Breteau
authors.forename: M
authors.initials: M
authors.lastname: Demasure
authors.forename: A
authors.initials: A
authors.lastname: Favre
authors.forename: R
authors.initials: R
authors.lastname: Leloup
authors.forename: J
authors.initials: J
authors.lastname: Lescrainier
authors.forename: R
authors.initials: R
authors.lastname: Sabattier
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002817:Chordoma / Q000150:complications / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D003050:Coccyx; D005214:Fast Neutrons; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010166:Palliative Care; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy / Q000379:methods*; D012447:Sacrum; D013125:Spinal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D016019:Survival Analysis