Effect of dexamethasone on invasion of human squamous cell carcinoma cells into collagen gel.
The effect of dexamethasone (Dex) on the ability to invade type I collagen gel was investigated in two cell lines of oral squamous cell carcinoma (SCC). At concentrations higher than 10(-8) M, Dex significantly suppressed the invasive growth of SCC cells into the gel. The same concentrations of Dex led to a decrease in urokinase type plasminogen activator (u-PA) synthesis and an increase in plasminogen activator inhibitor type 1 (PAI-1) synthesis by SCC cells. These findings suggest that Dex inhibits the invasiveness of SCC cells by decreasing their proteolytic activity.
Hayashido
Y
Y
First Department of Oral and Maxillofacial Surgery, Osaka University Faculty of Dentistry, Japan.
Shirasuna
K
K
Sugiura
T
T
Nakashima
M
M
Matsuya
T
T
D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D003094:Collagen; D003907:Dexamethasone / Q000494:pharmacology*; D005782:Gels; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006801:Humans; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000517:prevention & control*; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D017395:Plasminogen Activator Inhibitor 1 / Q000096:biosynthesis* / Q000235:genetics; D014062:Tongue Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014568:Urokinase-Type Plasminogen Activator / Q000096:biosynthesis* / Q000235:genetics
D005782:Gels; D009363:Neoplasm Proteins; D017395:Plasminogen Activator Inhibitor 1; D003907:Dexamethasone; D003094:Collagen; D014568:Urokinase-Type Plasminogen Activator