title: Homeostatic disruption and depression.
abstract: A putative model is presented for the nature of depression. It relies upon changes in core and defense homeostatic activity, subjecting the person either to minor or major depression. The former corresponds with the interaction between assessed brain emotion and altered organic elements which disrupt homeostasis. This is in contrast to the latter, which corresponds with the disruption of several homeostatic systems. We suggest that the frequency and severity of depression may be regulated by biological markers that represent the homeostatic baseline of biochemical, biophysical and mutual data system appraisals. In this framework, the relationship of the coefficient to the baseline of the homeostatic threshold levels evaluates the intensity of depression. The type of depression depends on the properties of the negative feedback mechanism which are replaced either by abnormal (retarded depression), or by a positive feedback mechanism (agitated depression). Homeostasis eliminates depression.
authors.affiliation: Sha'ar Menashe Medical Center for Mental Health, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Naisberg
mesh_terms: D003863:Depression / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology; D005246:Feedback; D006706:Homeostasis; D006801:Humans; D008954:Models, Biological