title: Patch testing in an aged population without dermatitis: high prevalence of patch test positivity.
abstract: BACKGROUND
  Epidermal immune function has been observed to decline in the aged.
  
  
  OBJECTIVE
  The purpose of this study was to determine the prevalence and relevance of patch test reactivity in an aged population without dermatitis and compare this with patch test reactivity in healthy younger volunteers.
  
  
  METHODS
  Patch testing with the North American Contact Dermatitis Group standard tray was performed on 82 healthy volunteers ranging in age from 68 to 87 years (mean age, 75 years), and the results were compared with those of 41 healthy younger volunteers (mean age, 24 years). A questionnaire regarding cutaneous symptoms was administered to both groups.
  
  
  RESULTS
  Thirty subjects in the older population (37%) had one or more positive patch test results compared with 6 members of the control group (15%) (P = .01). Common sensitizers in the older group included balsam of Peru (7[9%]), fragrance (8[10%]), neomycin (6[7%]), nickel (5[6%]), and methylchloroisothiazolinone/methylisothiazolinone (3[4%]). A history of severe pruritus (without dermatitis) was associated with positive patch test results to balsam of peru and nickel.
  
  
  CONCLUSIONS
  A high prevalence of positive patch test results in an aged population without dermatitis was observed. Factors contributing to to the high prevalence of patch test reactivity in the aged population may include cumulative exposure to potential allergens over time, a preserved ability to develop contact allergy, and altered percutaneous absorption. Patch testing in the aged must be interpreted carefully because the results may relate to past rather than present relevance.
authors.affiliation: Department of Dermatology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157-1071, USA.
authors.forename: H C
authors.initials: HC
authors.lastname: Mangelsdorf
authors.forename: A B
authors.initials: AB
authors.lastname: Fleischer
authors.forename: E F
authors.initials: EF
authors.lastname: Sherertz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D010328:Patch Tests / Q000592:standards*