Therapy with orally administered methoxsalen and ultraviolet A radiation during childhood increases the risk of basal cell carcinoma. The PUVA Follow-up Study.
A child was treated from age 18 months to 8 years with oral methoxsalen and ultraviolet A radiation (PUVA) for refractory psoriasis. Two basal cell cancers developed before age 21 years, suggesting that exposure to PUVA in childhood increases the risk of basal cell cancer.
Stern
R S
RS
Department of Dermatology, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.
Nichols
K T
KT
D000284:Administration, Oral; D000293:Adolescent; D002280:Basal Cell Carcinoma / Q000209:etiology* / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008730:Methoxsalen / Q000008:administration & dosage* / Q000009:adverse effects; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D011701:PUVA Therapy / Q000009:adverse effects*; D011565:Psoriasis / Q000150:complications / Q000188:drug therapy; D012307:Risk Factors; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology; D013997:Time Factors
D008730:Methoxsalen