Lead resistance and sensitivity in Staphylococcus aureus.
Five lead-resistant strains of Staphylococcus aureus were isolated. Plasmid-free lead-sensitive variants were obtained from the three plasmid-bearing strains. Lead-resistant strains tolerated an approximately 600 x higher Pb(NO3)2 concentration than lead-sensitive strains. Both types of strains initially bound lead, but only the resistant strains accumulated the metal as an intracellular lead-phosphate.
Levinson
H S
HS
Department of Biology, Brandeis University, Waltham, MA 02254, USA.
Mahler
I
I
Blackwelder
P
P
Hood
T
T
D001431:Bacteriological Techniques; D011232:Chemical Precipitation; D003470:Culture Media; D007854:Lead / Q000493:pharmacokinetics* / Q000494:pharmacology*; D008854:Microscopy, Electron; D012680:Sensitivity and Specificity; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000378:metabolism* / Q000648:ultrastructure
D003470:Culture Media; D007854:Lead