Interleukin 8 as a novel target for intervention therapy in acute inflammatory diseases.
Aberrant production of interleukin 8 (IL-8) has been shown in various human inflammatory diseases. Recent investigations in animal models using either blocking antibodies against IL-8 or disruption of the gene encoding the IL-8 receptor have revealed the involvement of IL-8 in the recruitment of neutrophils and in neutrophil-associated tissue injury in acute inflammation. These studies suggest that IL-8 is a novel target to alleviate acute inflammation. This review describes the properties of IL-8 and discusses different therapeutic approaches to target IL-8, particularly the use of humanized monoclonal antibodies against IL-8 and inhibition of IL-8 gene transcription.
Harada
A
A
Department of Hygiene, School of Medicine, Kanazawa University, Ishikawa, Japan.
Mukaida
N
N
Matsushima
K
K
D000818:Animals; D018925:Chemokines / Q000276:immunology; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D016209:Interleukin-8 / Q000737:chemistry / Q000276:immunology*; D015394:Molecular Structure; D015398:Signal Transduction / Q000276:immunology*
D018925:Chemokines; D016209:Interleukin-8