title: Lead resistance and sensitivity in Staphylococcus aureus.
abstract: Five lead-resistant strains of Staphylococcus aureus were isolated. Plasmid-free lead-sensitive variants were obtained from the three plasmid-bearing strains. Lead-resistant strains tolerated an approximately 600 x higher Pb(NO3)2 concentration than lead-sensitive strains. Both types of strains initially bound lead, but only the resistant strains accumulated the metal as an intracellular lead-phosphate.
authors.affiliation: Department of Biology, Brandeis University, Waltham, MA 02254, USA.
authors.forename: H S
authors.initials: HS
authors.lastname: Levinson
authors.forename: I
authors.initials: I
authors.lastname: Mahler
authors.forename: P
authors.initials: P
authors.lastname: Blackwelder
authors.forename: T
authors.initials: T
authors.lastname: Hood
mesh_terms: D001431:Bacteriological Techniques; D011232:Chemical Precipitation; D003470:Culture Media; D007854:Lead / Q000493:pharmacokinetics* / Q000494:pharmacology*; D008854:Microscopy, Electron; D012680:Sensitivity and Specificity; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D003470:Culture Media; D007854:Lead