Inhibition of HBsAg secretion from Alexander cell line by Phyllanthus amarus.
Alexander cell line, an human hepatocellular carcinoma derived cell line which has the property of secreting HBsAg in the supernatant was used to study the antiviral property of phyllanthus amarus. Aquous extract of Phyllanthus amarus was evaluated for its in vitro ability to inhibit HBsAg secretion on a dose dependent manner. It was seen that P. amarus at 1mg/ml concentration on a single dose inhibited the secretion of HBsAg for a period of 48 hours. This experiment proved the anti hepatitis B virus property of P. amarus at cellular level and further confirmed its beneficial use in the treatment of acute and chronic hepatitis B and healthy carriers of HBV.
Jayaram
S
S
Department of Microbiology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani.
Thyagarajan
S P
SP
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000276:immunology / Q000821:virology*; D006514:Hepatitis B Surface Antigens / Q000187:drug effects*; D006801:Humans; D008113:Liver Neoplasms / Q000276:immunology / Q000821:virology*; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D006514:Hepatitis B Surface Antigens; D010936:Plant Extracts