title: Variations of the enzymatic activity of the rat's gum glycolytic cycle following administration of sweeteners.
abstract: The effects of saccharose and isomalt on the rat's gum carbohydrate metabolism have been studied through evaluation of the activity of hexokinase (HK), phosphoglucoisomerase (PGI), lactatedehydrogenase (LDH), glucose-6-phosphate-dehydrogenase (G6PD), phosphofructokinase (PFK) and phosphoglucomutase (PGM). The values obtained by administering a drink sweetened with 10% isomalt are significantly lower (p < 0.05) than those obtained in the animals that had the drink sweetened with 10% saccharose. Administration of the same amount of drinks through gastric tube showed an enzymatic activity similar to that of the rats in the control group. Intermediate metabolites of the glycidic metabolism would then be responsible for the lesions of the oral epithelium, as those obtained by administering high levels of vitamin A, through an increased synthesis of acids. The increase of HK, PFK and PK activity with respect to the control group in those rats that had the isomalt on the rat's gum glycolytic cycle enzymes was found to be lower than that detected for other polyalcohols.
authors.affiliation: Institute of Nutrition, University of L'Aquila.
authors.forename: S
authors.initials: S
authors.lastname: Seri
authors.forename: A
authors.initials: A
authors.lastname: D'Alessandro
authors.forename: M
authors.initials: M
authors.lastname: Seri
mesh_terms: D000818:Animals; D004187:Disaccharides / Q000378:metabolism*; D004798:Enzymes / Q000032:analysis*; D005881:Gingiva / Q000378:metabolism*; D006019:Glycolysis; D051381:Rats; D013395:Sucrose / Q000378:metabolism*; D013402:Sugar Alcohols / Q000378:metabolism*
chemical_list: D004187:Disaccharides; D004798:Enzymes; D013402:Sugar Alcohols; D013395:Sucrose; C016640:Palatinit