title: Determination of beta-blocker drugs in pharmaceutical preparations by non-suppressed ion chromatography.
abstract: A rapid and feasible chromatographic method for determining atenolol, metoprolol, alprenolol, oxprenolol, acebutolol and propranolol by non-suppressed ion chromatography is proposed. The mobile phase consisted of 50 mM nitric acid in an aqueous solution of 4% (v/v) acetonitrile. Detection limits are in the range 0.1-2.7 mg l-1. The method was successfully applied to the determination of beta-blockers in several pharmaceutical formulations.
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, University of Seville, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Ghanem
authors.forename: M A
authors.initials: MA
authors.lastname: Bello
authors.forename: M
authors.initials: M
authors.lastname: Callejón
authors.forename: A
authors.initials: A
authors.lastname: Guiraúm
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000032:analysis* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002845:Chromatography / Q000379:methods; D015203:Reproducibility of Results
chemical_list: D000319:Adrenergic beta-Antagonists