Proton magnetic resonance spectroscopy of a gray matter heterotopia.
We used proton magnetic resonance spectroscopy to examine resonances representing metabolites containing N-acetyl (NA) groups (predominantly N-acetyl aspartate), choline, and creatine within a large left-hemispheric gray matter heterotopia (GMH) in a 35-year-old man with corpus callosum agenesis. In contrast to normal brain tissue, including gray matter regions, heterotopic gray matter was characterized by relatively increased choline and creatine resonances and a normal NA signal. These data suggest increased cellular activity or persistent immature neuronal tissue in GMH relative to unaffected tissue.
Marsh
L
L
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305-5546, USA.
Lim
K O
KO
Sullivan
E V
EV
Lane
B
B
Spielman
D
D
D000328:Adult; D061085:Agenesis of Corpus Callosum; D001927:Brain Diseases / Q000378:metabolism*; D003337:Corpus Callosum / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011522:Protons
D011522:Protons