[Circulating interleukin-4 levels in acute phase Kawasaki disease].
We have measured the plasma levels of IL-4 in patients with Kawasaki disease, serially. The results were as follows: The plasma levels of IL-4 from patients with Kawasaki disease in acute phase (median 17 pg/ml) were significantly higher than those from the patients in convalescent phase (median 1.96 pg/ ml, p = 0.001) or from control children (median 7.64 pg/ml, p = 0.001). These findings imply that Th2 (or Tho) cells may be vigorously stimulated at an acute phase of this disease, and that IL-4 produced by these cells may possibly modulate the pathological conditions of this disease.
Hirao
J
J
First Department of Pediatrics, Dokkyo University School of Medicine.
Hibi
S
S
Andoh
T
T
Ichimura
T
T
D000208:Acute Disease; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D015847:Interleukin-4 / Q000097:blood*; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood*
D015847:Interleukin-4