title: Analysis of the recent cluster of invasive fungal sinusitis at the Toronto Hospital for Sick Children.
abstract: OBJECTIVE
  The aim of this study was to review the eight histopathologically proven cases of invasive fungal sinusitis that occurred at the Toronto Hospital for Sick Children between 1985 and 1995, seven of which that clustered between March 1990 and February 1992.
  
  
  METHODS
  A retrospective review of the relevant cases and a review of the literature are presented.
  
  
  METHODS
  A clinical review of this rare, life-threatening entity, occurring almost exclusively in severely neutropenic patients is presented and compared to the relevant clinical findings from an analysis of this series, the largest reported to date and first to document a significant clustering (p < .01).
  
  
  CONCLUSIONS
  We conclude, based on epidemiologic evidence, that this clustering was directly related to the release of airborne fungal spores from dormant soil reservoirs disturbed during hospital construction. Therefore, we strongly advocate increased vigilance with respect to precautions against airborne pathogens wherever severely neutropenic hosts are treated.
authors.affiliation: Department of Otolaryngology, University of Toronto Faculty of Medicine, Ontario.
authors.forename: E A
authors.initials: EA
authors.lastname: Lueg
authors.forename: R H
authors.initials: RH
authors.lastname: Ballagh
authors.forename: V
authors.initials: V
authors.lastname: Forte
mesh_terms: D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use; D000741:Anemia, Aplastic / Q000150:complications; D000935:Antifungal Agents / Q000627:therapeutic use; D001230:Aspergillus / Q000302:isolation & purification*; D002648:Child; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications; D008297:Male; D009089:Mucor / Q000302:isolation & purification*; D009503:Neutropenia; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications; D012189:Retrospective Studies; D012852:Sinusitis / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D009396:Wilms Tumor / Q000150:complications
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B