Tissue concentration of dimetridazole in laying hens.
After laying hens had been dosed orally with dimetridazole (DMZ) for 3 days (50 and 250 mg/kg body weight (b.w.)) or intramuscularly, also for 3 days (50 mg/kg b.w.), the residues were determined in serum, liver, breast and thigh muscle by liquid chromatography. The limit of determination was 0.01 micrograms/g. The maximum concentration of DMZ was found at 1 h following application. After oral doses (50 and 250 mg/kg b.w.) no residues were found in muscle (breast and thigh) at 48 and 72 h, respectively. After intramuscular injection, residues in thigh muscle were below 0.01 micrograms/g at 72 h but breast muscle (injection site) still had concentrations above this level. Bioavailability (F > 80%) and some pharmacokinetic parameters were determined. The elimination half-lives from serum were 2.56h and 2.69h, after both oral doses, respectively, and 2.88 h after intramuscular application.
Posyniak
A
A
Department of Pharmacology and Toxicology, National Veterinary Research Institute, Pulawy, Poland.
Semeniuk
S
S
Zmudzki
J
J
Niedzielska
J
J
Biernacki
B
B
D000284:Administration, Oral; D000818:Animals; D000981:Antiprotozoal Agents / Q000097:blood / Q000493:pharmacokinetics*; D001682:Biological Availability; D002645:Chickens; D002853:Chromatography, Liquid; D004131:Dimetridazole / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006207:Half-Life; D007273:Injections, Intramuscular; D014018:Tissue Distribution
D000981:Antiprotozoal Agents; D004131:Dimetridazole