Discovery of FK 506 analogues that are nontoxic to mouse pancreatic beta cells in vitro but show diabetogenic potential when administered to the rat.
Mollison
K W
KW
Abbott Laboratories, Abbott Park, Illinois 60064-3500, USA.
Andrews
J M
JM
Fey
T A
TA
Miller
L N
LN
Krause
R A
RA
Bretheim
P T
PT
Brandt
J A
JA
Wagner
R
R
Lane
B C
BC
Hsieh
G C
GC
Luly
J R
JR
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002460:Cell Line; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects* / Q000502:physiology; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D051381:Rats; D011914:Rats, Inbred BN; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D016559:Tacrolimus / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000633:toxicity; D022021:Tacrolimus Binding Proteins
C102915:A 85917; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D006360:Heat-Shock Proteins; D007328:Insulin; D011993:Recombinant Fusion Proteins; C058028:immunomycin; D022021:Tacrolimus Binding Proteins; D016559:Tacrolimus