title: T cell involvement in glomerular injury.
abstract: The mechanisms of glomerular injury are multiple: one aspect is cell-mediated immunity in inflammatory kidney disease. Its fundamental role has been established within the last decade. T cells seem to play a regulatory role in the course of inflammation not only in the proliferative and crescentic disease, but also in nonproliferative glomerulonephritis. T cells become increasingly important in the pathogenesis of both glomerular and interstitial kidney diseases and seem to determine course and prognosis. The recent advances in understanding the mechanisms of T cell-mediated inflammation in kidney disease offer new approaches in therapy.
authors.affiliation: Medizinische Klinik I, Hospital Cologne-Mertheim, Academic Hospital, University of Cologne, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Merkel
authors.forename: M
authors.initials: M
authors.lastname: Marx
authors.forename: K O
authors.initials: KO
authors.lastname: Netzer
authors.forename: M
authors.initials: M
authors.lastname: Weber
mesh_terms: D007249:Inflammation / Q000276:immunology / Q000473:pathology; D007674:Kidney Diseases / Q000276:immunology / Q000473:pathology; D007678:Kidney Glomerulus / Q000276:immunology / Q000293:injuries / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology