title: I-131 localization in acute megakaryocytic leukemia.
abstract: A case of acute megakaryocytic leukemia in a 13-month-old infant was encountered in whom an abnormal bone scan was associated with abnormal I-131 MIBG uptake in the femoral bone marrow. The normal platelet will take up MIBG and thus, uptake of this radiopharmeceutical by the malignant megakaryocyte, a platelet precursor, may be caused by the same mechanism.
authors.affiliation: Division of Nuclear Medicine, University of Michigan Medical Center, Ann Arbor 48109-0028, USA.
authors.forename: A
authors.initials: A
authors.lastname: Leung
authors.forename: B
authors.initials: B
authors.lastname: Shapiro
authors.forename: M
authors.initials: M
authors.lastname: Brown
mesh_terms: D019797:3-Iodobenzylguanidine; D001792:Blood Platelets / Q000000981:diagnostic imaging / Q000378:metabolism; D001853:Bone Marrow / Q000000981:diagnostic imaging* / Q000378:metabolism; D017809:Fatal Outcome; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D007223:Infant; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D007462:Iodobenzenes / Q000493:pharmacokinetics; D007947:Leukemia, Megakaryoblastic, Acute / Q000000981:diagnostic imaging* / Q000378:metabolism; D008533:Megakaryocytes / Q000000981:diagnostic imaging / Q000378:metabolism; D010521:Periosteum / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012272:Ribs / Q000000981:diagnostic imaging; D012447:Sacrum / Q000000981:diagnostic imaging; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine