Hemolytic anemia provoked by recombinant alpha-interferon.
A 30-year-old female with chronic hepatitis C treated with recombinant alpha-interferon developed serious hemolytic anemia after receiving 10 million units a day for 4 weeks. The results of Coombs' tests were negative before and after interferon therapy. The hemolytic anemia gradually improved after the withdrawal of recombinant alpha-interferon and the administration of methyl-prednisolone. The clinical course suggested that the recombinant alpha-interferon had provoked the hemolytic anemia.
Takase
K
K
First Department of Internal Medicine, Mie University School of Medicine, Japan.
Nakano
T
T
Hamada
M
M
Shiraki
K
K
Oohashi
Y
Y
Kihira
T
T
Tameda
Y
Y
D000328:Adult; D000743:Anemia, Hemolytic / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006526:Hepatitis C / Q000628:therapy; D006521:Hepatitis, Chronic / Q000628:therapy / Q000821:virology; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D011994:Recombinant Proteins; D013997:Time Factors
D000998:Antiviral Agents; D005938:Glucocorticoids; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D008775:Methylprednisolone