Alcohol dehydrogenases: molecular biology and gene regulation.
The mammalian alcohol dehydrogenase genes are a closely related gene family, and show complex patterns of expression. The promoters contain multiple cis-acting elements that are binding sites for transcription factors. Both positive and negative cis-acting elements have been found. The binding of transcription factors to these sites differs among tissues. The complexity of the promoters allows different amounts of expression of the ADHs in many tissues.
Edenberg
H J
HJ
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202-5122, USA.
Brown
C J
CJ
Zhang
L
L
D000426:Alcohol Dehydrogenase / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D002460:Cell Line; D015971:Gene Expression Regulation, Enzymologic; D006367:HeLa Cells; D006801:Humans; D005810:Multigene Family; D011401:Promoter Regions, Genetic; D014157:Transcription Factors / Q000378:metabolism
D014157:Transcription Factors; D000426:Alcohol Dehydrogenase