Lymphocytes produce specific alkaline phosphatase after in vitro stimulation or after in vivo infection with HIV-1.
A unique alkaline phosphatase isoform found in the serum of HIV-1 infected patients is thought to originate from CD4 lymphocytes. Destruction of activated CD4 lymphocytes after HIV-1 infection is probably responsible for the appearance of this isoform in circulation. This band-10 alkaline phosphatase isoform is thus useful as an early marker for detecting AIDS in children born to HIV-1 infected mothers.
Murthy
V V
VV
Department of Laboratory Medicine, Albert Einstein College of Medicine, The Bronx, New York, USA.
D000469:Alkaline Phosphatase / Q000378:metabolism*; D015704:CD4 Antigens / Q000276:immunology; D002457:Cell Extracts / Q000737:chemistry; D004789:Enzyme Activation; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D007525:Isoelectric Focusing; D007527:Isoenzymes / Q000737:chemistry; D008214:Lymphocytes / Q000201:enzymology* / Q000378:metabolism; D015997:Neonatal Screening; D010835:Phytohemagglutinins / Q000494:pharmacology
D015704:CD4 Antigens; D002457:Cell Extracts; D007527:Isoenzymes; D010835:Phytohemagglutinins; D000469:Alkaline Phosphatase