[Effect of 2-methyl-4-amino-6-hydroxypyrimidine on the effectiveness of antibiotic therapy in experimental staphylococcal infection in the context of immunosuppression].
The experiments on mice with Staphylococcus infection at the background of immune suppression due to the treatment with prednisolone or imuran showed that the use of 2-methyl-4-amino-6-oxypyrimidine, a derivative of pyrimidine, increased the animal survival, their lifespan and the efficacy of the tobramycin therapy.
Ismagilova
A F
AF
Zarudiĭ
F S
FS
Davydova
V A
VA
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001379:Azathioprine / Q000627:therapeutic use; D004357:Drug Synergism; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008136:Longevity / Q000187:drug effects; D051379:Mice; D011239:Prednisolone / Q000627:therapeutic use; D011743:Pyrimidines / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D015996:Survival Rate; D014031:Tobramycin / Q000627:therapeutic use*
C096002:2-methyl-6-amino-6-hydroxypyrimidine; D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D011743:Pyrimidines; D011239:Prednisolone; D001379:Azathioprine; D014031:Tobramycin
Vliianie 2-metil-4-amino-6-oksipirimidina na éffektivnost antibiotikoterapii éksperimental'noĭ stafilokokkovoĭ infektsii na fone immunosupressii.