title: An unusual type of primary cerebral hemihypotrophy with signs of dysfunctional neuronal migration.
abstract: We describe the neuropathological features of a complex brain malformation characterized by cerebral hemihypotrophy with ipsilateral lissencephaly, periventricular nodular heterotopia and macrogyria. The contralateral hemisphere showed only slight alterations of the gyral pattern and a limited periventricular gray matter heterotopia. The clinical picture of the patient, who died at the age of 15 years, consisted of severe oligophrenia, intractable seizures and left hemiparesis. We discuss the nosological status of this neuronal migration disorder of apparently unknown origin.
authors.affiliation: Laboratory of Neuropathology, University of Siena, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Malandrini
authors.forename: F
authors.initials: F
authors.lastname: Lo Russo
authors.forename: M
authors.initials: M
authors.lastname: Villanova
authors.forename: R
authors.initials: R
authors.lastname: Salvestroni
authors.forename: F
authors.initials: F
authors.lastname: Sicurelli
authors.forename: C
authors.initials: C
authors.lastname: Salvadori
authors.forename: C
authors.initials: C
authors.lastname: Paolozzi
authors.forename: G C
authors.initials: GC
authors.lastname: Guazzi
mesh_terms: D000293:Adolescent; D001921:Brain / Q000002:abnormalities* / Q000473:pathology*; D002465:Cell Movement; D004832:Epilepsy, Absence / Q000150:complications; D004830:Epilepsy, Tonic-Clonic / Q000150:complications; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D009474:Neurons / Q000502:physiology*