[The effect of prenatal stress on the development of hypophyseal gonadotropic function in male rats].
Significant changes of the aromatase and 5 alpha-reductase hypothalamic activity were found in juvenile prenatally stressed male Wistar rats. The blood plasma testosterone level increased following niftolide (NF) or 1, 4, 6-androstatine-3, 17-dione (ATD) administration. Prenatal stress seems to exert a modifying effect upon the regulating mechanisms of the pituitary gonadotropin function, lowering the functional reserves of the hypothalamo-hypophyseal-testicular axis in pre- and postpubertal male rats.
Tarasenko
L V
LV
Sinitsyn
P V
PV
Reznikov
A G
AG
D000726:Androgen Antagonists / Q000494:pharmacology; D000733:Androstatrienes / Q000494:pharmacology; D000818:Animals; D001141:Aromatase / Q000378:metabolism; D047072:Aromatase Inhibitors; D042944:Cholestenone 5 alpha-Reductase; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D005485:Flutamide / Q000494:pharmacology; D006065:Gonadotropins, Pituitary / Q000502:physiology*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000201:enzymology / Q000503:physiopathology; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D012741:Sexual Maturation / Q000187:drug effects / Q000502:physiology; D013312:Stress, Physiological / Q000201:enzymology / Q000503:physiopathology*
D000726:Androgen Antagonists; D000733:Androstatrienes; D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors; D006065:Gonadotropins, Pituitary; C011658:androsta-1,4,6-triene-3,17-dione; D005485:Flutamide; D010088:Oxidoreductases; D001141:Aromatase; D042944:Cholestenone 5 alpha-Reductase
Vliianie prenatal'nogo stressa na stanovlenie gonadotropnoĭ funktsii gipofiza u samtsov krys.