CD22 regulates thymus-independent responses and the lifespan of B cells.
The B-lymphocyte-restricted glycoprotein CD22 is expressed on mature IgM+IgD+ B cells, and is capable of binding to ligands on T and B cells. CD22 can interact with both the B-cell antigen receptor (BCR) complex and signalling molecules, including the protein tyrosine phosphatase SHP1 (PTP1C, SHP), a putative negative regulator of BCR signalling. Thus CD22 may facilitate interactions with lymphocytes and regulate the threshold of BCR signalling. To define the in vivo function of CD22, we generated CD22-deficient mice. Here we show that CD22 is required for normal antibody responses to thymus-independent antigens and regulates the lifespan of mature B cells.
Otipoby
K L
KL
Department of Immunology, University of Washington Medical Center, Seattle 98195, USA.
Andersson
K B
KB
Draves
K E
KE
Klaus
S J
SJ
Farr
A G
AG
Kerner
J D
JD
Perlmutter
R M
RM
Law
C L
CL
Clark
E A
EA
D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000502:physiology*; D000944:Antigens, Differentiation, B-Lymphocyte / Q000235:genetics / Q000502:physiology*; D017209:Apoptosis; D001402:B-Lymphocytes / Q000276:immunology / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D015815:Cell Adhesion Molecules; D016922:Cellular Senescence / Q000235:genetics / Q000502:physiology; D017353:Gene Deletion; D037102:Lectins; D008213:Lymphocyte Activation; D051379:Mice; D051918:Sialic Acid Binding Ig-like Lectin 2; D013154:Spleen / Q000166:cytology; D013950:Thymus Gland / Q000166:cytology
D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; C497868:Cd22 protein, mouse; D015815:Cell Adhesion Molecules; D037102:Lectins; D051918:Sialic Acid Binding Ig-like Lectin 2; D002118:Calcium