title: Pediatric tracheal homograft reconstruction: a novel approach to complex tracheal stenoses in children.
abstract: OBJECTIVE
  Tracheal stenosis can be a life-threatening problem in children. Long-segment tracheal stenosis and recurrent tracheal stenosis are especially problematic. Tracheal homograft reconstruction represents a novel therapeutic modality for these patients.
  
  
  METHODS
  Cadaveric trachea is harvested, fixed in formalin, washed in thimerosal (Methiolate), and stored in acetone. The stenosed tracheal segment is opened to widely patent segments proximally and distally. The anterior cartilage is excised and the posterior trachealis muscle or tracheal wall remains. A temporary silicone rubber intraluminal stent is placed and absorbable sutures secure the homograft. Regular postoperative bronchoscopic treatment clears granulation tissue. The stent is removed endoscopically after epithelialization over the homograft. Twenty-four children with severe tracheal stenosis (age 5 months to 18 years, mean +/- standard error of the mean = 8.18 +/- 1.21 years) underwent tracheal homograft reconstruction. All but one had had previous unsuccessful reconstructive attempts. Ten lesions were congenital, nine were posttraumatic, and five were due to prolonged intubation.
  
  
  RESULTS
  Follow-up ranged from 5 months to 10 years (3.79 +/- 0.70 years). Twenty patients survive (20/24 = 83%), 16 without any airway problems. Four patients are still undergoing treatment. One patient requiring emergency extracorporeal membrane oxygenator support before the operation died 10 days after tracheal homograft reconstruction. Another patient with severe preoperative mediastinal sepsis died 3.5 months after tracheal homograft reconstruction. Two patients with functional airways died late of unrelated problems.
  
  
  CONCLUSIONS
  Tracheal homograft reconstruction demonstrates encouraging short-term to medium-term results for children with severe recurrent tracheal stenosis. Postoperative bronchoscopic and histologic studies provide evidence of epithelialization and support the expectation of good long-term results.
authors.affiliation: Great Ormond Street Hospital for Children, London, United Kingdom.
authors.forename: J P
authors.initials: JP
authors.lastname: Jacobs
authors.forename: M J
authors.initials: MJ
authors.lastname: Elliott
authors.forename: M P
authors.initials: MP
authors.lastname: Haw
authors.forename: C M
authors.initials: CM
authors.lastname: Bailey
authors.forename: C
authors.initials: C
authors.lastname: Herberhold
mesh_terms: D000293:Adolescent; D001999:Bronchoscopy; D002102:Cadaver; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D016377:Organ Transplantation / Q000379:methods; D012086:Reoperation; D015607:Stents; D016019:Survival Analysis; D014132:Trachea / Q000637:transplantation*; D014135:Tracheal Stenosis / Q000209:etiology / Q000601:surgery*; D014184:Transplantation, Homologous; D016896:Treatment Outcome