title: Studies on new antitumor antibiotics, leptofuranins A, B, C and D.I. Taxonomy, fermentation, isolation and biological activities.
abstract: The retinoblastoma protein (pRB) is inactivated in a wide variety of human cancers. In the course of our screening for antitumor antibiotics by using pRB-inactivated cells, an actinomycete identified as Streptomyces tanashiensis was found to produce four new active substances, leptofuranins A, B, C and D. The leptofuranins arrested the growth of normal cells and induced apoptotic cell death against tumor cells and cells transformed with the adenovirus E1A gene.
authors.affiliation: Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hayakawa
authors.forename: K
authors.initials: K
authors.lastname: Sohda
authors.forename: K
authors.initials: K
authors.lastname: Furihata
authors.forename: T
authors.initials: T
authors.lastname: Kuzuyama
authors.forename: K
authors.initials: K
authors.lastname: Shin-ya
authors.forename: H
authors.initials: H
authors.lastname: Seto
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000302:isolation & purification / Q000378:metabolism; D002460:Cell Line; D005663:Furans / Q000302:isolation & purification / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D011753:Pyrones / Q000302:isolation & purification / Q000378:metabolism; D051381:Rats; D013302:Streptomyces / Q000145:classification* / Q000378:metabolism
chemical_list: D000903:Antibiotics, Antineoplastic; D005663:Furans; D011753:Pyrones; C103028:leptofuranin A; C103029:leptofuranin B; C103030:leptofuranin C; C103031:leptofuranin D