Host factors and the pathogenesis of HIV-induced disease.
The level of human immunodeficiency virus (HIV) replication in patients reflects a balance between stimulatory and inhibitory host factors (particularly endogenous cytokines). New information concerning the cellular co-receptors for HIV and the cellular tropism of different strains of virus will advance our understanding of HIV-induced pathogenesis and suggests new therapeutic and preventive strategies.
Fauci
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AS
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D016207:Cytokines / Q000502:physiology*; D018450:Disease Progression; D006678:HIV / Q000502:physiology*; D015658:HIV Infections / Q000276:immunology* / Q000517:prevention & control / Q000628:therapy / Q000635:transmission / Q000821:virology*; D006801:Humans; D007113:Immunity, Innate; D008264:Macrophages / Q000821:virology; D009000:Monocytes / Q000821:virology; D018121:Receptors, Cytokine / Q000235:genetics / Q000502:physiology*; D015728:Receptors, HIV / Q000235:genetics / Q000502:physiology*; D014766:Viremia; D014779:Virus Replication
D016207:Cytokines; D018121:Receptors, Cytokine; D015728:Receptors, HIV