Lidocaine pharmacokinetics after cardiac arrest and external cardiopulmonary resuscitation.
Although prolonged cardiopulmonary resuscitation may impair drug metabolism, plasma lidocaine concentrations tended to remain within the therapeutic range after cardiopulmonary resuscitation lasting up to 30 minutes. Thus, the effects of cardiopulmonary resuscitation on lidocaine metabolism appear to be of little importance in the usual clinical situation.
Hendrie
J
J
Department of Emergency Medicine, Austin and Repatriation Medical Center, University of Melbourne, Australia.
O'Callaghan
C J
CJ
D000368:Aged; D000369:Aged, 80 and over; D000889:Anti-Arrhythmia Agents / Q000097:blood*; D002302:Cardiac Output / Q000502:physiology; D016887:Cardiopulmonary Resuscitation; D005260:Female; D006323:Heart Arrest / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D008012:Lidocaine / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014018:Tissue Distribution
D000889:Anti-Arrhythmia Agents; D008012:Lidocaine