title: Cholesterol vesicles in areas of gastric metaplasia of gallbladder epithelium.
abstract: Gastric metaplasia is a frequent epithelial change in gallbladder of lithiasic patients. Particles consistent with cholesterol-containing vesicles were searched in areas overlying gastric metaplastic cells, in gastric metaplastic cells, in areas overlying normal-looking epithelial cells and in normal-looking epithelial cells in 25 patients with radiolucent calculi and 10 control patients undergoing cholecystectomy for other reasons. Important trends were found confirming the peculiar role of mucous layer adherent to metaplastic gallbladder epithelium in beginning the nucleation process and interesting pictures concerning the formation of uni- and multilamellar vesicles in these "nucleating areas" were seen.
authors.affiliation: School of Gastroenterology, University of Ferrara, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Caselli
authors.forename: A
authors.initials: A
authors.lastname: Aleotti
authors.forename: G
authors.initials: G
authors.lastname: Navarra
authors.forename: P
authors.initials: P
authors.lastname: Carcoforo
authors.forename: F
authors.initials: F
authors.lastname: Cervellati
authors.forename: V
authors.initials: V
authors.lastname: Alvisi
mesh_terms: D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000032:analysis*; D011992:Endosomes / Q000737:chemistry / Q000648:ultrastructure; D004848:Epithelium / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D005704:Gallbladder / Q000473:pathology* / Q000648:ultrastructure*; D005753:Gastric Mucosa / Q000473:pathology / Q000648:ultrastructure*; D006801:Humans; D008297:Male; D008679:Metaplasia; D008875:Middle Aged
chemical_list: D002784:Cholesterol