title: [New phospholipids--inhibitors of human immunodeficiency virus reproduction. Synthesis and antiviral activity].
abstract: Several novel phosphatidic acid derivatives of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine were synthesized, which contained dialkylphosphatidyl, dialkylthiophosphatidyl moieties, as well as diacylphosphatidyl moiety with either 14,14,14-trifluoro-12-oxatetradecanoyl or natural acyl residues inherent in egg yolk phosphatidylcholine. Diacylphosphatidyl derivatives of glycyrrhetinic acid were also prepared. All the synthesized compounds exhibited significant anti-HIV activity. The glycyrrhetinic acid derivatives are of special interest because of their low toxicity and a supposedly different mechanism of action.
authors.forename: E L
authors.initials: EL
authors.lastname: Vodovozova
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Pavlova
authors.forename: M A
authors.initials: MA
authors.lastname: Polushkina
authors.forename: A A
authors.initials: AA
authors.lastname: Rzhaninova
authors.forename: M M
authors.initials: MM
authors.lastname: Garaev
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Molotkovskiĭ
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002460:Cell Line; D006678:HIV / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D010743:Phospholipids / Q000138:chemical synthesis* / Q000494:pharmacology*; D013057:Spectrum Analysis; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D019380:Anti-HIV Agents; D010743:Phospholipids
vernacular_title: Novye fosfolipidy--ingibitory reproduktsii virusa immunodefitsita cheloveka. Sintez i antivirusnaia aktivnost'.