Studies on new antitumor antibiotics, leptofuranins A, B, C and D.I. Taxonomy, fermentation, isolation and biological activities.
The retinoblastoma protein (pRB) is inactivated in a wide variety of human cancers. In the course of our screening for antitumor antibiotics by using pRB-inactivated cells, an actinomycete identified as Streptomyces tanashiensis was found to produce four new active substances, leptofuranins A, B, C and D. The leptofuranins arrested the growth of normal cells and induced apoptotic cell death against tumor cells and cells transformed with the adenovirus E1A gene.
Hayakawa
Y
Y
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Sohda
K
K
Furihata
K
K
Kuzuyama
T
T
Shin-ya
K
K
Seto
H
H
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000302:isolation & purification / Q000378:metabolism; D002460:Cell Line; D005663:Furans / Q000302:isolation & purification / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D011753:Pyrones / Q000302:isolation & purification / Q000378:metabolism; D051381:Rats; D013302:Streptomyces / Q000145:classification* / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D005663:Furans; D011753:Pyrones; C103028:leptofuranin A; C103029:leptofuranin B; C103030:leptofuranin C; C103031:leptofuranin D