title: [Study of plasma and hepatic hydrolysis of nitroxinil derivatives].
abstract: Seven esters derivatives of Nitroxinil were prepared and their structures were assigned by IR and 1H-NMR spectroscopy. The rate of plasma and hepatic hydrolysis were evaluated in vitro in sheep and rabbit. In view of this profile of activity, pivaloyl derivative merits evaluation, in vivo.
authors.affiliation: Laboratoire de Chimie Pharmaceutique, Faculté de Pharmacie, Toulouse.
authors.forename: G
authors.initials: G
authors.lastname: Baziard-Mouysset
authors.forename: M
authors.initials: M
authors.lastname: Alvinerie
authors.forename: P
authors.initials: P
authors.lastname: Galtier
authors.forename: M
authors.initials: M
authors.lastname: Ane-Margail
authors.forename: R
authors.initials: R
authors.lastname: Floch
authors.forename: M
authors.initials: M
authors.lastname: Payard
mesh_terms: D000818:Animals; D006868:Hydrolysis; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D009611:Nitroxinil / Q000031:analogs & derivatives* / Q000097:blood* / Q000378:metabolism; D011355:Prodrugs; D011817:Rabbits; D012756:Sheep
chemical_list: D011355:Prodrugs; D009611:Nitroxinil
vernacular_title: Etude de l'hydrolyse plasmatique et hépatique de dérivés du Nitroxinil.