Intracavernous injection of linsidomine chlorhydrate in monkeys: lack of toxic effect with long-term use.
OBJECTIVE
We sought to investigate whether linsidomine chlorhydrate (SIN1, the active metabolite of molsidomine and a nitric oxide donor) has a toxic effect when used chronically for the treatment of impotence.


METHODS
We gave 50 intracavernous injection of 1.5 mg SIN1 over 25 weeks to each of 5 monkeys.


RESULTS
Four monkeys consistently responded with erections of sufficient rigidity and duration (mean 47.5 +/- 3.3 min), and none of the five evidenced histopathologic changes of the cavernous tissue.


CONCLUSIONS
SIN1 appears to be a safe option for the pharmacotherapy of erectile dysfunction.
von Heyden
B
B
Department of Urology, University of California, School of Medicine, San Francisco, USA.
Brock
G B
GB
Martinez-Piñeiro
L
L
Lue
T F
TF
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D007022:Hypotension / Q000139:chemically induced; D008252:Macaca fascicularis; D008254:Macaca nemestrina; D008297:Male; D008981:Molsidomine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D010410:Penile Erection / Q000187:drug effects; D010413:Penis / Q000187:drug effects* / Q000473:pathology; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000633:toxicity*
D014665:Vasodilator Agents; C002385:linsidomine; D008981:Molsidomine