[Use of neurotransplantation in the treatment of Parkinson's disease].
The outcomes of transplantation of the human embryonal mid-brain into the striatum of patients with Parkinson's disease are presented. For this, a procedure for obtaining, isolating, preparing the human embryonic midbrain, as well as a method for stereotactic administration of embryonal nerve tissue suspension having high dopaminergic neuron levels into the patients' striatum are specified. Patients underwent neurological examinations by the international protocol Core Assessment Program for Intracerebral Transplantation including monthly video recording within 3 months before and 3-24 months after surgery. Electrophysiological, neuropsychological, and immunological examinations were made at the same intervals. Most patients had positive dynamics: diminution of the severity of main disease symptoms, reduction in the efficiency of a single dose of DOPA-containing drugs, decrease in the magnitude of side effects of drug therapy.
Ugriumov
M V
MV
Shabalov
V A
VA
Fedorova
N V
NV
Popov
A P
AP
Shtok
V N
VN
Sotnikova
E I
EI
Melikian
A G
AG
Gatina
T A
TA
Fetisov
S O
SO
Arkhipova
N A
NA
Buklina
S B
SB
Lutsenko
G V
GV
D000328:Adult; D016380:Brain Tissue Transplantation; D004594:Electrophysiology; D005260:Female; D016332:Fetal Tissue Transplantation; D005500:Follow-Up Studies; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D008636:Mesencephalon / Q000637:transplantation*; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000276:immunology / Q000503:physiopathology / Q000601:surgery*; D011597:Psychomotor Performance; D013238:Stereotaxic Techniques; D009927:Tissue and Organ Procurement; D016896:Treatment Outcome
Ispol'zovanie neĭrotransplantatsii v lechenii bolezni parkinsona.