Anti-Salmonella activity of CP-99,219, a novel azabicyclo-naphthridone fluoroquinolone.
The antimicrobial activity of CP-99,219 was determined by the broth dilution method against 67 clinical isolates of Salmonella typhi. Ninety-one percent of the isolates were inhibited by < or = 0.12 mg/l of this quinolone, and all the 67 by 2.0 mg/l. Its inhibitory activity was slightly superior to ciprofloxacin and norfloxacin and significantly greater than ampicillin, augmentin, chloramphenicol and trimethoprim-sulphamethoxazole.
Qadri
S M
SM
King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Cunha
B A
BA
Ueno
Y
Y
Walters
E A
EA
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests; D009287:Naphthyridines / Q000494:pharmacology*; D012485:Salmonella typhi / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; C080163:trovafloxacin