Development of primary hypothyroidism with antithyroglobulin, antiperoxidase, and blocking-type thyrotropin receptor antibodies after radiation therapy for neuroblastoma.
We describe a girl with hypothyroidism and blocking-type thyrotropin receptor antibodies that developed after chemotherapy and irradiation of the neck region for neuroblastoma. Results of thyroid studies before treatment were normal. Twenty months after completion of treatment, the girl had hypothyroidism with high titers of blocking-type thyrotropin receptor antibodies, antithyroglobulin, and antiperoxidase antibodies.
Kikawa
Y
Y
Department of Pediatrics, Fukui Medical School, Matsuoka, Japan.
Takeuchi
M
M
Sudo
M
M
Iida
Y
Y
Kasagi
K
K
Konishi
J
J
D000906:Antibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology; D001667:Binding, Competitive / Q000528:radiation effects; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D007011:Hypoparathyroidism / Q000209:etiology* / Q000276:immunology; D008207:Lymphatic Metastasis; D009447:Neuroblastoma / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D009195:Peroxidase / Q000276:immunology* / Q000528:radiation effects; D011878:Radiotherapy / Q000009:adverse effects*; D011989:Receptors, Thyrotropin / Q000276:immunology* / Q000528:radiation effects; D013954:Thyroglobulin / Q000276:immunology* / Q000528:radiation effects; D013997:Time Factors
D000906:Antibodies; D011989:Receptors, Thyrotropin; D013954:Thyroglobulin; D009195:Peroxidase