title: [Primary biliary cirrhosis with polymyositis successfully treated with prednisolone and ursodeoxycholic acid].
abstract: A 65-year-old woman was given a diagnosis of polymyositis in April 1991. She was treated with prednisolone until December 1993, at which time muscle strength had increased and high blood pressure had developed. In May 1994 she was hospitalized for muscle weakness and mild liver dysfunction. Prednisolone was given and the levels of hepatobiliary enzymes decreased. Immunological examination revealed strongly positive results for anti-mitochondria antibody and M-2 antibody, which lead to the diagnosis of primary biliary cirrhosis. administration of ursodeoxycholic acid in addition to prednisolone was followed by normalization of liver function and a decrease in the production of the autoantibodies. Although polymyositis can be complicated by autoimmune diseases, reports of complication by primary biliary cirrhosis are rare, here we report that treatment with the combination of ursodeoxycholic acid and prednisolone was successful in a patient with liver dysfunction and primary biliary cirrhosis.
authors.affiliation: Department of Geriatric Medicine, Osaka University Medical School.
authors.forename: M
authors.initials: M
authors.lastname: Ono
authors.forename: T
authors.initials: T
authors.lastname: Niinobu
authors.forename: Y
authors.initials: Y
authors.lastname: Yamanaka
authors.forename: O
authors.initials: O
authors.lastname: Yasuda
authors.forename: H
authors.initials: H
authors.lastname: Rakugi
authors.forename: H
authors.initials: H
authors.lastname: Ikegami
authors.forename: T
authors.initials: T
authors.lastname: Miki
authors.forename: T
authors.initials: T
authors.lastname: Ogihara
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002756:Cholagogues and Choleretics / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000188:drug therapy* / Q000209:etiology; D017285:Polymyositis / Q000150:complications / Q000188:drug therapy*; D011239:Prednisolone / Q000008:administration & dosage*; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage*
chemical_list: D000893:Anti-Inflammatory Agents; D002756:Cholagogues and Choleretics; D014580:Ursodeoxycholic Acid; D011239:Prednisolone