[Involvement of adrenergic mechanisms in developing the nervous syndrome of high pressure and nitrogen narcosis].
Involvement of the adrenergic mediator system in central mechanisms of hyperbaric nitrogen narcosis or the high pressure nervous syndrome (NSHP) produced by nitrogen or heliox gas mixtures under increased pressure was studied in mice and rabbit experiments with the use of pharmacological substances-analyzers. Accumulated data are indicative of lack of a significant role of the adrenergic system in the NSHP genesis and a protective effect of activation of the central but not peripheric adrenergic mediation in development of the behavioural and electrophysiological symptomatics of nitrogen narcosis. Mechanisms of NSHP and nitrogen narcosis and possible principles of pharmacological correction are under discussion.
Sledkov
A I
AI
Institute of Evolutional Physiology and Biochemistry of IM Sechenov RAN, Saint-Petersburg.
Bernarskii
K V
KV
Shilina
M N
MN
D018663:Adrenergic Agents / Q000494:pharmacology*; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects* / Q000503:physiopathology; D002682:Chinchilla; D004146:Dioxanes / Q000494:pharmacology; D004569:Electroencephalography; D004809:Ephedrine / Q000494:pharmacology; D006610:High Pressure Neurological Syndrome / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D007222:Inert Gas Narcosis / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D051379:Mice; D011312:Pressure / Q000009:adverse effects; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits; D015398:Signal Transduction
D018663:Adrenergic Agents; D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D004146:Dioxanes; D011433:Propranolol; D004809:Ephedrine; C009143:proroxan
Uchastie adrenergicheskikh mekhanismov v razvitii nervnogo sindroma vysokikh davlenii i azotnogo narkoza.