Role of activation of bradykinin B2 receptors in disruption of the blood-brain barrier during acute hypertension.
Cellular mechanisms which account for disruption the blood-brain barrier during acute hypertension are not clear. The goal of this study was to determine the role of synthesis/release of bradykinin to activate B2 receptors in disruption of the blood-brain barrier during acute hypertension. Permeability of the blood-brain barrier was quantitated by clearance of fluorescent-labeled dextran before and during phenylephrine-induced acute hypertension in rats treated with vehicle and Hoe-140 (0.1 microM). Phenylephrine infusion increased arterial pressure, arteriolar diameter and clearance of fluorescent dextran by a similar magnitude in both groups. These findings suggest that disruption of the blood-brain barrier during acute hypertension is not related to the synthesis/release of bradykinin to activate B2 receptors.
Mayhan
W G
WG
Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha 68198-4575, USA.
D000208:Acute Disease; D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D001920:Bradykinin / Q000031:analogs & derivatives / Q000096:biosynthesis* / Q000378:metabolism / Q000494:pharmacology; D065168:Bradykinin Receptor Antagonists; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D010656:Phenylephrine; D051381:Rats; D011920:Rats, Inbred WF; D043782:Receptor, Bradykinin B2; D018002:Receptors, Bradykinin / Q000378:metabolism / Q000502:physiology*; D014699:Venules
D065168:Bradykinin Receptor Antagonists; D043782:Receptor, Bradykinin B2; D018002:Receptors, Bradykinin; D010656:Phenylephrine; C065679:icatibant; D001920:Bradykinin