title: Development of cochlear active mechanisms in humans differs between gender.
abstract: Despite onset of function early during the third term of gestation, the human auditory system demonstrates continued maturation, thought previously to occur primarily at the neural level. The electromotile properties of outer hair cells appear to contribute substantially to hearing sensitivity and frequency selectivity and lead to the generation of otoacoustic emissions (OAEs). This report demonstrates continued development of cochlear active mechanisms (i.e. end-organ level) after onset of cochlear function, as reflected by OAEs. Significant gender differences also are reported, corresponding to recently observed intersex differences in cochlear length and precursory to gender differences observed in the adult.
authors.affiliation: UPRESA CNRS 5020, Claude Bernard University, Lyon, France. morlet@rockfeller1.univ-lyon1.fr
authors.forename: T
authors.initials: T
authors.lastname: Morlet
authors.forename: E
authors.initials: E
authors.lastname: Perrin
authors.forename: J D
authors.initials: JD
authors.lastname: Durrant
authors.forename: A
authors.initials: A
authors.lastname: Lapillonne
authors.forename: C
authors.initials: C
authors.lastname: Ferber
authors.forename: R
authors.initials: R
authors.lastname: Duclaux
authors.forename: G
authors.initials: G
authors.lastname: Putet
authors.forename: L
authors.initials: L
authors.lastname: Collet
mesh_terms: D003051:Cochlea / Q000254:growth & development*; D005260:Female; D018072:Hair Cells, Auditory, Outer / Q000254:growth & development; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D017084:Otoacoustic Emissions, Spontaneous; D012727:Sex Characteristics