Acute renal failure in cardiac surgical patients, potentiated by gentamicin and calcium.
A retrospective study in coronary artery bypass graft patients was undertaken to assess the effect of gentamicin and a bypass prime with a high calcium on the incidence of renal failure. Patients who received both Haemaccel (polygeline, Hoechst Marion Roussel) (calcium concentration 6.25 mmol/l) in the bypass prime and gentamicin perioperatively had a higher incidence of renal failure compared with those who received only Haemaccel (P = 0.005), only gentamicin (P = 0.002) or neither (P = 0.0001). We suggest that the combination be avoided in this group of patients.
Schneider
M
M
Department of Anaesthesia, Royal Perth Hospital, W.A.
Valentine
S
S
Clarke
G M
GM
Newman
M A
MA
Peacock
J
J
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D019072:Antibiotic Prophylaxis / Q000009:adverse effects; D002118:Calcium / Q000009:adverse effects*; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D004357:Drug Synergism; D005839:Gentamicins / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D010952:Plasma Substitutes / Q000009:adverse effects*; D011097:Polygeline / Q000009:adverse effects*; D011183:Postoperative Complications; D012189:Retrospective Studies
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010952:Plasma Substitutes; D011097:Polygeline; D002118:Calcium