[The effect of benzodiazepine derivatives on the formation of brain edema-swelling in the dynamics of the posttraumatic period].
In experiments on rats the influence of diazepam, cinazepam, and phenazepam (0.5 mg/kg, intraperitoneally) on the development of brain edema in the dynamics of acute craniocerebral injury was studied. The diazepam and phenazepam prevented the development of brain edema in the post-traumatic period. The antiedematous effect of benzodiazepines was connected with their influence on metabolism of the brain.
Novikov
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D000208:Acute Disease; D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001929:Brain Edema / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D001930:Brain Injuries / Q000150:complications* / Q000378:metabolism; D003975:Diazepam / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D051381:Rats; D013997:Time Factors
C571710:3-hydroxy-7-bromo-5-(ortho-chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one; D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam; D003975:Diazepam
Vliianie proizvodnykh benzodiazepina na formirovanie oteka-nabukhaniia golovnogo mozga v dinamike posttravmaticheskogo perioda.