Effect of simvastatin on ejection fraction in cardiac transplant recipients.
In a prospective observational study, we looked at the effects of simvastatin on cardiac function, lipids, and blood pressure after cardiac transplantation. Our study suggests that simvastatin treatment is associated with improved ejection fraction in cardiac transplant recipients independent of effects attributable to the lipid profile.
Jenkins
G H
GH
Hormones and Blood Pressure Research Group, Imperial College School of Medicine, National Heart and Lung Institute, Heart Science Centre, Harefield Middlesex, United Kingdom.
Grieve
L A
LA
Yacoub
M H
MH
Singer
D R
DR
D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology / Q000627:therapeutic use; D004452:Echocardiography; D005260:Female; D006321:Heart / Q000187:drug effects*; D016027:Heart Transplantation / Q000502:physiology*; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D008148:Lovastatin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D019821:Simvastatin; D013318:Stroke Volume / Q000187:drug effects*
D002121:Calcium Channel Blockers; D000960:Hypolipidemic Agents; D008148:Lovastatin; D019821:Simvastatin