Uniform matrix stability study designs.
Uniform matrix designs for drug stability studies are introduced and compared to standard matrix designs. Comparisons are made on the basis of design moment, D-efficiency, uncertainty, G-efficiency, and statistical power. It is shown that uniform matrix designs provide superior statistical properties with the same or fewer design points than standard matrix designs.
Murphy
J R
JR
Eli Lilly and Company, Indianapolis, Indiana 46285, USA.
D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D008432:Mathematical Computing; D013223:Statistics as Topic / Q000379:methods*