[Estradiol receptors in cervical intraepithelial neoplasia and cervico-uterine cancer].
The objective of this study was to know if there is a correlation in contents o (R + E) in biopsies from patients pre and post-menopausal, in normal cervix with cervical intraepithelial neoplasia (NIC) and invasive cancer. Thirty four patients with abnormal cytology; colposcopy was carried out, and two biopsies were taken from the suspicious lesion, they were sent for histopathological study, and for estrogenic receptors; both studies were correlated later. It was seen that (R +/- E) concentration is higher in intraepithelial lesions of low and high degree than in control patients; and it was not so in premenopausal with invasive cancer where (R +/- E) are much lower, as to postmenopausal (R + E) concentration is higher specially in invasive cancer. It is concluded that the study on quantification to (R + E) in cervical pathology means a good alternative in hormonal treatment, as it has been seen in mammary pathology, and so, more research has to be done.
González-Sánchez
J L
JL
Hospital de Gineco-Obstetricia Luis Castelazo Ayala. Instituto Mexicano del Seguro Social. México, D.F.
Calzada-Sánchez
L
L
Galindo-Vital
A
A
Salazar-Esquivel
L
L
D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000737:chemistry*; D002584:Cervix Uteri / Q000737:chemistry*; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause; D017697:Premenopause; D011960:Receptors, Estrogen / Q000032:analysis*; D002583:Uterine Cervical Neoplasms / Q000737:chemistry*
D011960:Receptors, Estrogen
Receptores a estradiol en neoplasia intraepitelial cervical y cáncer cervicouterino.