Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine "mini-cluster".
MIG is a gamma interferon-inducible T cell chemoattractant that is a member of the chemokine family of cytokines. P1 clones containing the MIG gene were found also to contain the gene of a related chemokine, INP10. We localized MIG and INP10 to 4q21 by FISH, demonstrated by pulsed field gel electrophoresis that MIG and INP10 are distant from the tight cluster of other CXC chemokine genes at 4q12-->q13, and determined that MIG and INP10 are oriented head to tail with their start codons separated by less than 16 kb.
Lee
H H
HH
Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda MD 20892, USA.
Farber
J M
JM
D054357:Chemokine CXCL10; D054370:Chemokine CXCL9; D018925:Chemokines / Q000235:genetics*; D019743:Chemokines, CXC; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D016207:Cytokines / Q000235:genetics*; D018076:DNA, Complementary; D005796:Genes; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D036341:Intercellular Signaling Peptides and Proteins; D005810:Multigene Family
C080810:CXCL9 protein, human; D054357:Chemokine CXCL10; D054370:Chemokine CXCL9; D018925:Chemokines; D019743:Chemokines, CXC; D016207:Cytokines; D018076:DNA, Complementary; D036341:Intercellular Signaling Peptides and Proteins