title: Disorders of smell, taste, and food intake in a patient with a dorsomedial thalamic infarct.
abstract: BACKGROUND
  We report that a lasting deficit in the hedonic character of olfactory and gustatory perception can be observed in bilateral dorsomedial and intralaminar thalamic lesions.
  
  
  METHODS
  A 68-year-old patient abruptly presented with vigilance disorders associated with a reduction of olfactory and gustatory perceptions. A severe drop in appetite for foods and a weight loss of 10 kg were observed, which were partially reversed with time. Two years later, the main persisting disorder was a change in the quality of perceptions: odors and taste were perceived either in a neutral way, their pleasant character having disappeared, or as unpleasant. However, identification was preserved. MRI showed that lesions principally involved the dorsomedial thalamic nuclei and the adjacent part of the intralaminar nuclei.
  
  
  CONCLUSIONS
  This case suggests that the dorsomedial thalamus may play a role in the hedonic perception of food, thus affecting short-term regulation of food intake, and may possibly have a role in the long-term control of body weight.
authors.affiliation: Service de Rééducation et Convalescence Neurologiques, Centre Hospitalier Universitaire, Lille, France.
authors.forename: M
authors.initials: M
authors.lastname: Rousseaux
authors.forename: P
authors.initials: P
authors.lastname: Muller
authors.forename: I
authors.initials: I
authors.lastname: Gahide
authors.forename: Y
authors.initials: Y
authors.lastname: Mottin
authors.forename: M
authors.initials: M
authors.lastname: Romon
mesh_terms: D000368:Aged; D000855:Anorexia / Q000209:etiology*; D002544:Cerebral Infarction / Q000150:complications*; D004172:Diplopia / Q000209:etiology; D004408:Dysgeusia / Q000209:etiology*; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D011939:Mental Recall; D012678:Sensation Disorders / Q000209:etiology*; D012903:Smell; D013788:Thalamus / Q000098:blood supply / Q000502:physiology*