Aminophylline stability in total parenteral nutrition admixtures.
Aminophylline stability (dose 0.5 and 0.75 g) was estimated in typical AIO nutrient admixtures [Salviamin 12.5% 1000.0 cm3; Glucose 500 g; Intralipid 20% 500.0 cm3; Soluvit N; Vitalipid N Adult; Addamel N; total volume 3000.0 cm3] prepared in DIMIX bags [Diffuplast srl, Italy]. The pH. particle size distribution [Coulter Counter ZM] and theophylline concentration [Spectrophotometer Pye Unicam] were measured immediately after preparation and after 24, 48, 72 hours of storage in low temperature and then after 24 hours in room temperature. Aminophylline proved to be stable in above mentioned doses and now is commonly added into AIO in practice.
Ciszewska-Jedrasik
M
M
Department of Applied Pharmacy, Drug Science Institute, School of Medicine, Warsaw, Poland.
Knyt
A
A
Pertkiewicz
M
M
D000628:Aminophylline / Q000032:analysis*; D001993:Bronchodilator Agents / Q000032:analysis*; D004355:Drug Stability; D005526:Food, Formulated / Q000032:analysis*; D010289:Parenteral Nutrition, Total
D001993:Bronchodilator Agents; D000628:Aminophylline