title: An apparent pH-induced effect on extended wear hydrogel lens water content.
abstract: Numerous studies have examined the separate issues of precorneal tearfilm pH and hydrogel lens water content. None have examined the two issues in an associated, clinical fashion. Earlier research by this author has shown that stabilized hydrogel lens anterior surface pH correlates with established values for the precorneal tearfilm pH. This technique was therefore paired with two different methods of hydrogel lens water content assessment to determine if there was a predictable tear pH-related effect on soft lens hydration. Sixty-five volunteer subjects were fitted with either 38% (polymacon) or 58% (etafilcon A) water content hydrogel lenses on an extended-wear basis. The in situ hydrogel lens anterior surface pH was measured with a flat-surfaced, self-referenced pH electrode 5 min after initial fitting, and on subsequent extended wear follow-up examinations. On each follow-up, associated lens water content was determined by gravimetric and/or refractive analysis, yielding a total of 517 paired data points over a 33 month period. While the anterior lens surface pH increased in a nonlinear fashion with immediate duration of extended lens wear [p < 0.001 analysis of variance (ANOVA) by number of days extended lens wear], the water content decreased in a nonlinear fashion under the same conditions (p < 0.001 by ANOVA). Correlation of these two nonlinear functions yielded a negatively sloped linear regression (r = 0.99 and 0.97) for each material. The slopes of the resultant linear functions were significantly different (p < 0.01) by t-test; the higher water content material exhibited a greater sensitivity to pH. The routine labeling of pH-induced water content changes by hydrogel lens manufacturers would provide an objective model for clinical lens behavior, and assist in lens type and parameter selection when fitting extended-wear soft lenses. Additionally, as other lens materials are characterized, it may be possible to model the "ideal" hydrogel material in terms of apparent pH-dependent or-independent behavior.
authors.affiliation: U.S. Naval Medical Center, Department of Ophthalmology, San Diego, California, USA.
authors.forename: M R
authors.initials: MR
authors.lastname: Lattimore
mesh_terms: D003262:Contact Lenses, Extended-Wear; D005500:Follow-Up Studies; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D006863:Hydrogen-Ion Concentration; D011092:Polyethylene Glycols; D012031:Refractometry; D012044:Regression Analysis; D013666:Tears / Q000378:metabolism; D014867:Water / Q000032:analysis*
chemical_list: D014867:Water; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols