title: Changes in portal hemodynamics and acute rejection in the first 2 weeks after orthotopic liver transplantation. A prospective Doppler ultrasound study.
abstract: OBJECTIVE
  To analyze changes in Doppler ultrasound variables of the portal vein in relation to liver biopsy findings, the authors performed a prospective study of 316 Doppler ultrasound examinations in the first 2 weeks after orthotopic liver transplantation on 23 patients.
  
  
  METHODS
  Recordings were obtained daily from the portal vein (diameter, maximum velocity, and flow). Correlations were explored between the Doppler ultrasound findings and histologic data. The chi-square test was used to analyze differences in Doppler ultrasound variables in patients with and without acute rejection.
  
  
  RESULTS
  In our series of 23 patients, acute rejection was diagnosed by liver biopsy in nine of them (39%). Changes in portal vein diameter, maximum velocity, and flow did not correlate consistently with liver biopsy findings, due to a multifactorial origin. Changes in portal hemodynamics were observed in patients with hepatic artery thrombosis, portal vein stenosis, acute rejection, and sepsis.
  
  
  CONCLUSIONS
  Although routine screening using Doppler ultrasound proved to be useful for the determination of rapid changes in portal hemodynamics within a short time, serial Doppler ultrasound examinations were not helpful in predicting acute rejection.
authors.affiliation: Department of Diagnostic Radiology, University Hospital Groningen, The Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: Kok
authors.forename: M J
authors.initials: MJ
authors.lastname: Slooff
authors.forename: P M
authors.initials: PM
authors.lastname: Peeters
authors.forename: J H
authors.initials: JH
authors.lastname: Zwaveling
authors.forename: C M
authors.initials: CM
authors.lastname: Bijleveld
authors.forename: C E
authors.initials: CE
authors.lastname: Gi-van Loon
authors.forename: I J
authors.initials: IJ
authors.lastname: Klompmaker
authors.forename: E B
authors.initials: EB
authors.lastname: Haagsma
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001706:Biopsy; D001783:Blood Flow Velocity; D002648:Child; D002675:Child, Preschool; D006084:Graft Rejection / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D016031:Liver Transplantation / Q000473:pathology / Q000502:physiology*; D008875:Middle Aged; D011168:Portal System / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011446:Prospective Studies; D015203:Reproducibility of Results; D014182:Transplantation, Autologous; D018608:Ultrasonography, Doppler / Q000379:methods*