title: Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas.
abstract: The adverse prognostic impact of tumor hypoxia has been demonstrated in human malignancy. We report the effects of radiotherapy and hyperthermia (HT) on soft tissue sarcoma oxygenation and the relationship between treatment-induced changes in oxygenation and clinical treatment outcome. Patients receiving preoperative radiotherapy and HT underwent tumor oxygenation measurement pretreatment after the start of radiation/pre-HT and one day after the first HT treatment. The magnitude of improvement in tumor oxygenation after the first HT fraction relative to pretreatment baseline was positively correlated with the amount of necrosis seen in the resection specimen. Patients with <90% resection specimen necrosis experienced longer disease-free survival than those with > or = 90% necrosis. Increasing levels of tumor hypoxia were also correlated with diminished metabolic status as measured by P-31 magnetic resonance spectroscopy.
authors.affiliation: Department of Radiation Oncology, Duke University Comprehensive Cancer Center, Durham, North Carolina 27710, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Brizel
authors.forename: S P
authors.initials: SP
authors.lastname: Scully
authors.forename: J M
authors.initials: JM
authors.lastname: Harrelson
authors.forename: L J
authors.initials: LJ
authors.lastname: Layfield
authors.forename: R K
authors.initials: RK
authors.lastname: Dodge
authors.forename: H C
authors.initials: HC
authors.lastname: Charles
authors.forename: T V
authors.initials: TV
authors.lastname: Samulski
authors.forename: L R
authors.initials: LR
authors.lastname: Prosnitz
authors.forename: M W
authors.initials: MW
authors.lastname: Dewhirst
mesh_terms: D015687:Cell Hypoxia / Q000528:radiation effects; D006801:Humans; D006979:Hyperthermia, Induced; D009682:Magnetic Resonance Spectroscopy; D009336:Necrosis; D010092:Oximetry; D010100:Oxygen / Q000378:metabolism; D010759:Phosphorus Isotopes; D011048:Polarography; D011379:Prognosis; D011836:Radiation Tolerance; D012509:Sarcoma / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*
chemical_list: D010759:Phosphorus Isotopes; D010100:Oxygen