Immunologic parameters in cord blood indicating early-onset sepsis.
Different immunologic parameters were measured in cord blood to test their usefulness in the early diagnosis of early onset sepsis. Cord blood levels of circulating intercellular adhesion molecule-1 (cICAM-1), interleukin-6 (IL-6) and interleukin-8 (IL-8) were significantly elevated in septic compared to nonseptic neonates. No significant difference between either population was seen for cord blood C3a and elastase-alpha 1-proteinase inhibitor complex (E alpha 1 PI). Measured concentrations of cICAM-1, IL-6 and IL-8 in fetal and maternal blood did not correlate, indicating that the neonate's response to sepsis is clearly different from the mother. Our data suggest that cord blood measurements of cICAM-1, IL-6 and IL-8 might be useful in identifying neonates with early-onset sepsis.
Lehrnbecher
T
T
Department of Pediatrics, University of Würzburg, Germany.
Schrod
L
L
Rutsch
P
P
Roos
T
T
Martius
J
J
von Stockhausen
H B
HB
D004927:Escherichia coli Infections; D005312:Fetal Blood / Q000276:immunology*; D006192:Haemophilus Infections; D006193:Haemophilus influenzae; D006801:Humans; D007231:Infant, Newborn; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D015850:Interleukin-6 / Q000032:analysis; D016209:Interleukin-8 / Q000032:analysis; D018805:Sepsis / Q000175:diagnosis* / Q000276:immunology*
D015850:Interleukin-6; D016209:Interleukin-8; D018799:Intercellular Adhesion Molecule-1