Regulation of second messengers by the inositol polyphosphate 5-phosphatases.
The inositol polyphosphate 5-phosphatases are an enlarging family of enzymes that terminate the signals generated by the phosphoinositide kinases and phospholipase C. Given the diverse signalling functions of both the polyphosphoinositides and Ins(1,4,5)P3, it is predicted that the 5-phosphatases will play a critical role in regulating many cellular events, in particular membrane trafficking and cell growth.
Mitchell
C A
CA
Department of Medicine, Monash Medical School, Box Hill Hospital, Victoria, Australia.
Brown
S
S
Campbell
J K
JK
Munday
A D
AD
Speed
C J
CJ
D000595:Amino Acid Sequence; D000818:Animals; D017360:Arabidopsis; D017173:Caenorhabditis elegans; D000072181:Inositol Polyphosphate 5-Phosphatases; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000502:physiology; D010744:Phosphoric Monoester Hydrolases / Q000737:chemistry / Q000502:physiology*; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry / Q000502:physiology; D015290:Second Messenger Systems / Q000502:physiology*; D016415:Sequence Alignment
D009419:Nerve Tissue Proteins; D011506:Proteins; C097702:synaptojanin; D010744:Phosphoric Monoester Hydrolases; D000072181:Inositol Polyphosphate 5-Phosphatases