title: Chromosome 18 translocation (18;21) (p11.1;p11.1) associated with psychosis in one family.
abstract: In the course of recruiting families with 2 schizophrenic siblings for genome screening and linkage studies, a family was found with mental retardation, schizophrenia, and/or other related psychotic illnesses in individuals who also had an unbalanced or balanced translocation between chromosomes 21-18 [t(18;21)(p11.1;p11.1)]. The pericentric region of chromosome 18 has already been noted as a possible location of a gene for bipolar psychosis. The family described here provides further evidence that this region should be examined for a candidate psychosis gene.
authors.affiliation: Department of Psychiatry, SUNY at Stony Brook, NY 11794, USA.
authors.forename: A B
authors.initials: AB
authors.lastname: Smith
authors.forename: P
authors.initials: P
authors.lastname: Peterson
authors.forename: J
authors.initials: J
authors.lastname: Wieland
authors.forename: T
authors.initials: T
authors.lastname: Moriarty
authors.forename: L E
authors.initials: LE
authors.lastname: DeLisi
mesh_terms: D000328:Adult; D002871:Chromosome Banding; D002887:Chromosomes, Human, Pair 18; D002891:Chromosomes, Human, Pair 21; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics; D007621:Karyotyping; D008297:Male; D010375:Pedigree; D011618:Psychotic Disorders / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics; D014178:Translocation, Genetic