title: [Immunological indicators in children with laryngeal papillomatosis and possible ways of immunocorrection].
abstract: Clinicoimmunological characteristics were followed up in the course of laryngeal papillomatosis (LP) in 96 children. It was found that they had suppressed T-cell immunity, phagocytosis which still worsen with the disease aggravation and recurrences. A decrease in nonspecific resistance, properdin, lysozyme, complement and secretory IgA indicated impairment of nasopharyngeal and laryngeal local immunity. A scheme of combined treatment is proposed incorporating basic therapy with reaferon, systemic immunomodulators (thymalin, T-activin) and local immunocorrection. Such approach reduced the time of basic treatment and prolonged remission 2.5-3-fold.
authors.forename: T I
authors.initials: TI
authors.lastname: Garashchenko
authors.forename: T P
authors.initials: TP
authors.lastname: Markova
authors.forename: D G
authors.initials: DG
authors.lastname: Chuvirov
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology; D007223:Infant; D007370:Interferon Type I / Q000627:therapeutic use; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D007822:Laryngeal Neoplasms / Q000276:immunology* / Q000628:therapy*; D010212:Papilloma / Q000276:immunology* / Q000628:therapy*; D010455:Peptides / Q000627:therapeutic use; D010587:Phagocytosis; D011994:Recombinant Proteins; D013601:T-Lymphocytes / Q000276:immunology; D013949:Thymus Extracts / Q000627:therapeutic use; D013951:Thymus Hormones / Q000627:therapeutic use; D014165:Transfer Factor / Q000627:therapeutic use*
chemical_list: D000276:Adjuvants, Immunologic; D007136:Immunoglobulins; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D010455:Peptides; D011994:Recombinant Proteins; D013949:Thymus Extracts; D013951:Thymus Hormones; D014165:Transfer Factor; C032805:thymalin; C036191:T-activin
vernacular_title: Issledovanie immunologicheskikh pokazateleĭ u deteĭ s papillomatozom gortani i vozmozhnye puti immunokorrektsii.