[Testicular morphology in rats in the early and late periods after platidiam administration].
The experiments performed on Wistar rats showed morphological damages of the rat testis over a one-month period after platidiam administration (4 mg/kg, one-time intravenous injection), namely a decrease in the index of spermatogenesis, in the number of normal spermatogonia, Leydig cells, and testis tubes at the 12th stage of meiosis and an increase in the number of testis tubes squamous epithelium. In the remote period (3 and 6 month after platidiam administration) the recovery of morphological and functional state of the rat testis was observed.
Borovskaia
T G
TG
Fomina
T I
TI
Filippova
M V
MV
Smirnova
M E
ME
Gol'dberg
V E
VE
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002945:Cisplatin / Q000494:pharmacology*; D007985:Leydig Cells / Q000187:drug effects / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013076:Sperm Count / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013093:Spermatogonia / Q000187:drug effects / Q000473:pathology; D018709:Statistics, Nonparametric; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors
D000970:Antineoplastic Agents; D002945:Cisplatin
Morfologiia semennikov krys v rannie i otdalennye sroki posle vvedeniia platidiama.