title: Evaluation of etiological hypotheses and a study of early lesions in alcoholic pancreatitis.
abstract: Current understanding of the pathology of chronic pancreatitis secondary to chronic alcoholism is exclusively based on surgical biopsies or autopsy studies of the pancreatic gland from far-advanced stages of the disease. Biopsy of the pancreas is dangerous, and good experimental models for alcoholic pancreatitis are not available to evaluate the chronology of events in the pancreas. A classification system was proposed many years ago with various hypotheses on the pathogenesis of chronic pancreatitis. These hypotheses will be examined in relation to the empirical evidence.
authors.affiliation: New York Medical College, Our Lady of Mercy Medical Center, Bronx 10466, USA.
authors.forename: C S
authors.initials: CS
authors.lastname: Pitchumoni
mesh_terms: D000818:Animals; D000431:Ethanol / Q000378:metabolism / Q000633:toxicity; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000187:drug effects; D008247:Lysosomes / Q000187:drug effects; D008954:Models, Biological; D010179:Pancreas / Q000187:drug effects / Q000293:injuries / Q000378:metabolism; D010183:Pancreatic Ducts / Q000293:injuries / Q000473:pathology; D019512:Pancreatitis, Alcoholic / Q000209:etiology* / Q000378:metabolism / Q000473:pathology*; D011506:Proteins / Q000378:metabolism
chemical_list: D005609:Free Radicals; D011506:Proteins; D000431:Ethanol