title: [Pharmaokinetics of beta-escin after administration of various Aesculus extract containing formulations].
abstract: With a specific radioimmunoassay the pharmacokinetics and relative bioavailability of escin was measured after administration of different formulations containing Aesculus-extract. Of special interest was the relative bioavailability of escin after administration of a newly developed film-coated tablet with sustained release in comparison to a reference formulation. In a cross-over steady-state study in 24 volunteers bioequivalence of test and reference preparation could be demonstrated. The 90% confidence interval of the AUC (O-tau) was 98.3 to 120.9%.
authors.affiliation: Dr. Willmar Schwabe Arzneimittel, Karlsruhe, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Oschmann
authors.forename: A
authors.initials: A
authors.lastname: Biber
authors.forename: F
authors.initials: F
authors.lastname: Lang
authors.forename: H
authors.initials: H
authors.lastname: Stumpf
authors.forename: K
authors.initials: K
authors.lastname: Kunz
mesh_terms: D000328:Adult; D001682:Biological Availability; D018592:Cross-Over Studies; D004928:Escin / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010946:Plants, Medicinal / Q000737:chemistry*; D011863:Radioimmunoassay; D013608:Tablets, Enteric-Coated; D013810:Therapeutic Equivalency; D014020:Tissue Extracts / Q000493:pharmacokinetics
chemical_list: D013608:Tablets, Enteric-Coated; D014020:Tissue Extracts; D004928:Escin
vernacular_title: Pharmakokinetik von beta-Aescin nach Gabe verschiedener Aesculus-Extrakt enthaltender Formulierungen.