[The risk factors for the development of the multiple organ failure syndrome in destructive pancreatitis].
The role of neutrophil leukocytes in the development of the polyorgan failure syndrome during an unfavorable course of destructive pancreatitis is discussed. The examinations of 52 patients demonstrated a high correlation of neutrophil functional activity tests (nitroblue tetrazolium reduction test and leukocyte-platelet aggregation) and disorders of microcirculation and hepatorenal involvement (detected clinically and by laboratory tests). The "critical mass" of leukocytosis has been estimated: at least 18 . 10(9)/liter, at which the risk of polyorgan failure appreciably increases. The authors discuss the advisability of selective cytopheresis in a complex of intensive care for critical states involving endogenous poisoning and leukocytosis.
Vereshchagin
I P
IP
Zolotarev
A V
AV
Kuznetsov
D I
DI
D000208:Acute Disease; D000328:Adult; D005260:Female; D006801:Humans; D007964:Leukocytosis / Q000097:blood / Q000150:complications / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D010195:Pancreatitis / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors
Faktory riska razvitiia sindroma poliorgannoĭ nedostatochnosti pri destruktivnom pankreatite.