title: Methotrexate patient education: a quality improvement study.
abstract: OBJECTIVE
  To determine patients' knowledge of the safe use and toxicity of methotrexate (MTX) and to define educational interventions implemented by a rheumatology nurse that improved patients' understanding of MTX therapy.
  
  
  METHODS
  One hundred eighty-three patients from a university-based rheumatology clinic who were taking MTX completed an initial knowledge questionnaire concerning the proper use and possible toxicity of MTX. Following completion, a nurse reviewed the correct answers with each patient and provided written information on MTX. One hundred thirty-eight of these patients completed a followup questionnaire at the next visit or by mail. The questionnaires were analyzed, and a total MTX knowledge score was calculated.
  
  
  RESULTS
  MTX knowledge improved significantly between questionnaires; mean total score (+/- SD) increased from 7.32 +/- 3.99 to 10.23 +/- 3.29 (P < 0.001). After accounting for a person's initial questionnaire score, the addition of a supplemental "MTX pocket-card" was associated with a higher score on the follow-up questionnaire (adjusted odds ration [OR] = 2.37; 95% confidence interval [CI] 1.14, 4.95; P = 0.021). Patients over age 55 were 4 times more likely to have a poorer score compared with patients under age 45 (adjusted OR = 0.23; 95% CI 0.07, 0.73; P = 0.013).
  
  
  CONCLUSIONS
  Knowledge of the toxicity and safe use of MTX was significantly improved by a patient education program utilizing a rheumatology nurse. Older individuals appear to be at higher risk for knowledge deficits. A supplemental MTX pocket-card proved to be a simple but beneficial addition to our MTX educational program.
authors.forename: M R
authors.initials: MR
authors.lastname: Burma
authors.forename: J W
authors.initials: JW
authors.lastname: Rachow
authors.forename: S
authors.initials: S
authors.lastname: Kolluri
authors.forename: K G
authors.initials: KG
authors.lastname: Saag
mesh_terms: D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000451:nursing; D004521:Educational Measurement; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D015999:Multivariate Analysis; D009720:Nurse Clinicians; D010353:Patient Education as Topic / Q000458:organization & administration*; D011795:Surveys and Questionnaires; D017749:Total Quality Management
chemical_list: D018501:Antirheumatic Agents; D008727:Methotrexate