A nonidentifiability aspect of the two-stage model of carcinogenesis.
This paper discusses identifiability of the two-stage birth-death-mutation model of carcinogenesis. It is shown that the homogeneous version of the model is nonidentifiable; the same is all the more evident for its nonhomogeneous versions. This result implies that the model parameters cannot be uniquely estimated from time-to-tumor observations.
Hanin
L G
LG
Department of Mathematics, Wayne State University, Detroit, Michigan, USA.
Yakovlev AYu
D000818:Animals; D002455:Cell Division; D003043:Cocarcinogenesis; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D009154:Mutation; D009369:Neoplasms / Q000209:etiology / Q000235:genetics / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000473:pathology; D012307:Risk Factors