[Thrombomatch--an ELISA test for detection of antibodies to HLA antigens and platelet-specific antigens. Clinical experiences in compatibility testing of platelet transfusions].
We tested a new ELISA--called thrombomatch--for antibody detection against HLA- and platelet-specific antigens in comparison with MAIPA, Capture-P-Modified an lymphocytotoxicity. Sensitivity of the thrombomatch ist a little lower than the MAIPA, higher than lymphocytotoxicity and Capture-PM in the alloantibody detection. The thrombomatch is very helpful for a immunological monitoring of the antibody formation while long-term blood substitution in hemato-oncological patients. An antibody screening should be done in the lymphocytotoxicity and in the Elisa thrombomatch.
Barz
D
D
Abteilung Transfusionsmedizin, Universität Rostock, Deutschland.
Gatzka
E
E
Kollmorgen
I
I
D016824:Antigens, Human Platelet / Q000276:immunology*; D001787:Blood Group Incompatibility / Q000175:diagnosis* / Q000276:immunology; D001788:Blood Grouping and Crossmatching; D004797:Enzyme-Linked Immunosorbent Assay; D017707:Erythrocyte Transfusion; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007518:Isoantibodies / Q000032:analysis*; D007938:Leukemia / Q000276:immunology / Q000628:therapy; D008223:Lymphoma / Q000276:immunology / Q000628:therapy; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D017713:Platelet Transfusion; D012680:Sensitivity and Specificity
D016824:Antigens, Human Platelet; D006680:HLA Antigens; D007518:Isoantibodies
Thrombomatch--ein ELISA-Test zum Nachweis von Antikörpern gegen HLA-Antigene und plättchenspezifische Antigene. Klinische Erfahrungen bei der Kompatibilitätstestung vor Plättchentransfusionen.