title: Effects of a high-protein diet on mineral metabolism and struvite activity product in clinically normal cats.
abstract: OBJECTIVE
  To examine effects of high-protein diets (> 50% crude protein of dry matter) on urinary mineral excretion and struvite activity product ([Mg2+] x [NH4+] x [PO(4)3-]).
  
  
  METHODS
  14 clinically normal cats, 4 adult female and male cats for experiments 1 and 2, respectively, and 6 female kittens aged 4 months for experiment 3.
  
  
  METHODS
  Relations between dietary protein amount (25.9, 38.3, 51.4, and 65.4% crude protein [dry matter]) and urinary excretion of Mg, P, and Ca were examined in a 4 x 4-Latin square design (experiment 1). Struvite activity product, the index of solubility of struvite crystals, was determined when a high-protein diet (54.9%) was fed (experiment 2). Utilization of minerals in cats fed a high-protein diet long term was examined (experiment 3).
  
  
  RESULTS
  Water intake and urine volume increased with increasing dietary protein concentration. Urinary Mg2+ excretion was not affected (experiment 1) or was decreased (experiment 3) by higher protein intake, leading to lower urine Mg2+ concentration in groups fed higher protein amounts. Urine pH was decreased by high-protein intake. As a result, PO(4)3- concentration was decreased by high-protein intake (experiment 2), although total daily urinary excretion of P was increased. Consequently, struvite activity product tended to decrease in cats fed high-protein diets, indicating increase in struvite solubility. High-protein intake decreased Ca and P retention by increasing their fecal and urinary excretions, respectively.
  
  
  CONCLUSIONS
  As a consequence of the increase in urine volume and urine acidification, high-protein diets have potential ability to increase solubility of struvite crystals.
authors.affiliation: School of Veterinary Medicine, Azabu University, Sagamihara, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Funaba
authors.forename: M
authors.initials: M
authors.lastname: Hashimoto
authors.forename: C
authors.initials: C
authors.lastname: Yamanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Shimogori
authors.forename: T
authors.initials: T
authors.lastname: Iriki
authors.forename: S
authors.initials: S
authors.lastname: Ohshima
authors.forename: M
authors.initials: M
authors.lastname: Abe
mesh_terms: D000818:Animals; D001835:Body Weight; D002118:Calcium / Q000378:metabolism; D002415:Cats; D004032:Diet; D004044:Dietary Proteins; D004231:Diuresis; D005260:Female; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000378:metabolism; D017616:Magnesium Compounds / Q000652:urine*; D008297:Male; D008903:Minerals / Q000652:urine*; D010710:Phosphates / Q000652:urine*; D010758:Phosphorus / Q000378:metabolism; D012044:Regression Analysis; D000069877:Struvite
chemical_list: D004044:Dietary Proteins; D017616:Magnesium Compounds; D008903:Minerals; D010710:Phosphates; D010758:Phosphorus; D000069877:Struvite; D008274:Magnesium; D002118:Calcium