title: Actions of adrenomedullin on the rat adrenal cortex.
abstract: The actions of adrenomedullin on cAMP and aldosterone secretion have been investigated using an intact rat adrenal capsular preparation incubated in vitro. Adrenomedullin was found to cause a dose-dependent increase in aldosterone secretion, with a parallel increase in cAMP release. The minimum concentration of adrenomedullin required for significant stimulation of aldosterone secretion was 10nmol/l. Adrenomedullin did not affect ACTH-stimulated aldosterone secretion, but significantly inhibited endothelin-1 stimulated aldosterone secretion. We conclude that adrenomedullin is an aldosterone stimulant in the rat adrenal gland, acting through cAMP generation.
authors.affiliation: Department of Oral Pathology, St Bartholomew, London.
authors.forename: S
authors.initials: S
authors.lastname: Kapas
authors.forename: J P
authors.initials: JP
authors.lastname: Hinson
mesh_terms: D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D053607:Adrenomedullin; D000450:Aldosterone / Q000378:metabolism; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D019332:Endothelin-1 / Q000494:pharmacology; D005260:Female; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D019332:Endothelin-1; D010455:Peptides; D014665:Vasodilator Agents; D053607:Adrenomedullin; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D000242:Cyclic AMP