title: Ranitidine has no influence on tubular creatinine secretion.
abstract: Oral cimetidine competitively inhibits tubular secretion of creatinine. We investigated the potential of oral ranitidine, a comparable H2-receptor antagonist, to block tubular creatinine secretion. In 10 healthy subjects, clearances of inulin and endogenous creatinine were simultaneously measured before and after administration of a single oral dose of ranitidine. In all subjects the effect of 300 mg ranitidine was studied; 7 subjects with high tubular secretion also participated in an additional study, when 1,200 mg ranitidine was administered. Neither dose of ranitidine caused a significant change in glomerular filtration rate measured by inulin clearance, or in mean plasma creatinine or in mean creatinine clearance. We conclude that a single oral dose of 300-1,200 mg ranitidine does not inhibit tubular secretion of creatinine in normal subjects, probably due to a lower affinity of ranitidine for the transport carrier at the luminal tubular membrane in comparison with cimetidine.
authors.affiliation: Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: J G
authors.initials: JG
authors.lastname: van den Berg
authors.forename: M G
authors.initials: MG
authors.lastname: Koopman
authors.forename: L
authors.initials: L
authors.lastname: Arisz
mesh_terms: D000328:Adult; D003404:Creatinine / Q000378:metabolism*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D007684:Kidney Tubules / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D011899:Ranitidine / Q000494:pharmacology*
chemical_list: D006635:Histamine H2 Antagonists; D011899:Ranitidine; D003404:Creatinine