Genetic effects of binazine and hydralazine in vitro and in vivo.
The mutagenic and genotoxic activities of binazine and hydralazine were studied. In the Ames test, both with and without S-9 fraction, hydralazine was mutagenic in strains Salmonella typhimurium TA100 and TA1537, whereas binazine was not mutagenic in these strains. Both drugs were negative in mice micronucleus test.
Chłopkiewicz
B
B
Drug Institute, Warsaw, Poland.
Ejchart
A
A
Marczewska
J
J
D000818:Animals; D000959:Antihypertensive Agents / Q000633:toxicity*; D006830:Hydralazine / Q000633:toxicity*; D008297:Male; D051379:Mice; D009153:Mutagens / Q000633:toxicity*; D014032:Todralazine / Q000633:toxicity*
D000959:Antihypertensive Agents; D009153:Mutagens; D006830:Hydralazine; D014032:Todralazine