title: Short-term canine implantation of a glucose monitoring-telemetry device.
abstract: In this study we report the development and short-term in vivo evaluation of an integrated implantable device consisting of an amperometric glucose biosensor, a miniature potentiostat, a FM signal transmitter, and power supply. The device (dimensions: 5.0 x 7.0 x 1.5 cm) was implanted under the skin of medium-size anaesthetized dog. The experimental set-up included several methods for data collection: analog recording via wired X-T chart recorders; data collection by wearable microprocessor--data logger, and remote data collection via antenna and receiver linked to a computer-based data acquisition system. The device (sensor) performance was evaluated in vitro prior to implantation, using different model solutions simulating the physiological environment. A linear response to glucose concentration was obtained up to 25 mM glucose, with a sensitivity of 0.5 microA/mM. The results of short-term subcutaneous implantation of the integrated device reveal adequate monitoring of an artificially-induced glycaemia. The delay-time was 3-7 minutes. These tests demonstrate the feasibility of data transmission by the telemetry system through the skin of a medium-sized dog and allow the commencement of chronic in vivo experimentation.
authors.affiliation: Department of Chemical and Nuclear Engineering, School of Engineering, University of New Mexico, Albuquerque 87131, USA.
authors.forename: P
authors.initials: P
authors.lastname: Atanasov
authors.forename: S
authors.initials: S
authors.lastname: Yang
authors.forename: C
authors.initials: C
authors.lastname: Salehi
authors.forename: A L
authors.initials: AL
authors.lastname: Ghindilis
authors.forename: E
authors.initials: E
authors.lastname: Wilkins
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D001774:Blood Chemical Analysis / Q000295:instrumentation*; D001786:Blood Glucose / Q000378:metabolism*; D002138:Calibration; D004285:Dogs; D011211:Electric Power Supplies; D004867:Equipment Design; D005069:Evaluation Studies as Topic; D019736:Prostheses and Implants; D013686:Telemetry
chemical_list: D001786:Blood Glucose