title: Change in hemorrheological and biochemical parameters following membrane differential filtration.
abstract: BACKGROUND
  The elimination of high molecular weight proteins may have a positive influence on disorders of the microcirculation due to an improvement in rheological parameters. We therefore attempted to evaluate the rheological efficacy of membrane differential filtration (MDF).
  
  
  METHODS
  Ten patients suffering from macular disease underwent MDF. Rheological and biochemical parameters as well as visual acuity were determined one day before and after therapy: The study aimed at a reduction in plasma viscosity, standardized whole blood viscosity at hematocrit 0.45 and erythrocyte aggregation at hematocrit 0.3.
  
  
  RESULTS
  Severe side-effects were not observed. The rheological parameters were significantly reduced. In detail the posttreatment values were reduced as compared to the pretreatment values as follows: plasma viscosity 85%, standardised whole blood viscosity 86% (hematocrit 0.45), erythrocyte aggregation 59% (hematocrit 0.3), total protein 81%, IgG 66%, IgA 59%, IgM 33%, alpha-2-macroglobulin 30%, triglycerides 102%, total cholesterol 47%, VLDL cholesterol 94%, LDL cholesterol 33%, HDL cholesterol 62%. Visual acuity was improved in 7/10 patients.
  
  
  CONCLUSIONS
  MDF is a safe and highly effective method for lowering biochemical and improving rheological parameters which led to improvement in visual acuity. We have already replaced plasma exchange with MDF in our clinical practice of hemorrheological therapy.
authors.affiliation: Department of Ophthalmology, University of Cologne, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Brunner
authors.forename: R A
authors.initials: RA
authors.lastname: Widder
authors.forename: P
authors.initials: P
authors.lastname: Walter
authors.forename: H
authors.initials: H
authors.lastname: Borberg
authors.forename: K
authors.initials: K
authors.lastname: Oette
mesh_terms: D000368:Aged; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D001777:Blood Coagulation; D001781:Blood Component Removal; D001798:Blood Proteins / Q000378:metabolism; D004573:Electrolytes / Q000097:blood; D004903:Erythrocyte Aggregation; D005260:Female; D005374:Filtration / Q000379:methods*; D006400:Hematocrit; D006801:Humans; D008055:Lipids / Q000097:blood; D008268:Macular Degeneration / Q000628:therapy*; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D008970:Molecular Weight; D012212:Rheology; D016896:Treatment Outcome
chemical_list: D001798:Blood Proteins; D004573:Electrolytes; D008055:Lipids; D008567:Membranes, Artificial