On the dominant rhythm in the discharges of single postganglionic sympathetic neurones innervating the rat tail artery.
1. In anaesthetized rats, using a focal recording technique, activity was recorded from single sympathetic postganglionic neurones innervating the caudal ventral artery of the tail. The following hypotheses were tested: (i) that the frequency of the dominant rhythmic discharge of the neurones can be different from the frequency of the central respiratory rhythm (as indicated by rhythmic phrenic discharge); and (ii) that the dominant sympathetic rhythm is not reliant on afferent feedback carried in aortic, sinus and vagus nerves. 2. Four types of preparation were used: spontaneously breathing (group 1), artificially ventilated (group 2), artificially ventilated with vagi cut (group 3), and artificially ventilated with vagus and sino-aortic denervation (group 4). 3. The frequencies of the dominant sympathetic rhythm under control conditions were: group 1, 0.91 +/- 0.12 Hz (mean +/- S.E.M., n = 5); group 2, 0.81 +/- 0.04 Hz (n = 18); group 3, 0.83 +/- 0.03 Hz (n = 17); group 4, 0.95 +/- 0.06 Hz (n = 11). The frequency of the dominant sympathetic rhythm was different from that of the phrenic rhythm in thirty-five out of fifty-one cases. 4. The mean frequency of the dominant sympathetic rhythm was not influenced significantly by hypocapnic apnoea. 5. Hyperthermia increased the frequency of the phrenic rhythm whilst decreasing that of the dominant sympathetic rhythm. 6. In all cases the frequency of the dominant sympathetic rhythm was different from that of the artificial ventilation cycle. 7. It is concluded that the frequency of the dominant sympathetic rhythm can be different from that of central respiratory drive and that it is not "driven' by afferent feedback relayed via sinus, aortic and vagus nerves. 8. It is proposed that the dominant sympathetic rhythm is unlikely to be generated by a central respiratory oscillator.
Johnson
C D
CD
Department of Physiology, Royal Free Hospital School of Medicine, London, UK.
Gilbey
M P
MP
D000818:Animals; D001049:Apnea / Q000378:metabolism; D001158:Arteries / Q000378:metabolism; D004594:Electrophysiology; D005071:Evoked Potentials / Q000502:physiology; D005334:Fever; D005728:Ganglia, Sympathetic / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000378:metabolism* / Q000502:physiology; D010791:Phrenic Nerve / Q000378:metabolism / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012119:Respiration / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology; D013623:Tail