Cytokine-mediated communication by keratinocytes and Langerhans cells with dendritic epidermal T cells.
Dendritic epidermal T cells (DETC) are skin-specific members of the epithelial gamma delta T-cell family that reside normally in murine epidermis. Recent studies indicate that certain cytokines (e.g. IL-2, IL-7 and IL-15) secreted by neighboring cells promote their residence and regulate their immune function. Conversely, DETC regulate the function of neighboring keratinocytes and Langerhans cells by elaborating other cytokines (e.g. interferon-gamma, keratinocyte growth factor and colony-stimulating factors). This reciprocal interaction represents a unique model of cytokine-mediated intercellular communication by tissue-specific gamma delta T cells with nearby epithelial and antigen presenting cells.
Takashima
A
A
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas 75235, USA.
Bergstresser
P R
PR
D000818:Animals; D002450:Cell Communication / Q000276:immunology*; D016207:Cytokines / Q000096:biosynthesis / Q000502:physiology*; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism*; D004817:Epidermis / Q000276:immunology*; D006801:Humans; D015603:Keratinocytes / Q000276:immunology / Q000378:metabolism*; D007801:Langerhans Cells / Q000276:immunology / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism*
D016207:Cytokines