Transrearrangements as biomarkers for risk of lymphoid malignancy.
In this chapter we describe an assay for lymphocyte specific antigen receptor transrearrangements mediated by the V(D)J recombinase complex. Such transrearrangements occur in all normal individuals, are capable of increasing the immune repertoire and can be viewed as a readily available baseline measure of a type of genetic instability. In human and murine systems, the absolute number of some of these transrearrangements correlates at the population level with risk for the development of lymphoid malignancy.
Kirsch
I R
IR
National Cancer Institute-Navy Medical Oncology Branch, Bethesda, Maryland 20889-5105, USA.
Lista
F
F
D000818:Animals; D001260:Ataxia Telangiectasia / Q000235:genetics; D004254:DNA Nucleotidyltransferases / Q000235:genetics*; D004198:Disease Susceptibility; D015321:Gene Rearrangement / Q000235:genetics*; D005803:Genes, Immunoglobulin / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D008223:Lymphoma / Q000235:genetics*; D051379:Mice; D016513:Mice, SCID / Q000235:genetics; D016609:Neoplasms, Second Primary / Q000235:genetics*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D045567:VDJ Recombinases
D005819:Genetic Markers; D011948:Receptors, Antigen, T-Cell; D004254:DNA Nucleotidyltransferases; D045567:VDJ Recombinases