Enteric absorption of ciprofloxacin during tube feeding in the critically ill.
To determine the pharmacokinetic properties of ciprofloxacin in the critically ill, we studied seven mechanically ventilated patients with pneumonia during enteral feedings. Subjects received ciprofloxacin 750 mg every 12 h via nasogastric tube and serial serum drug concentrations were measured after the first and fourth dose. After the initial dose, the maximum serum concentration ranged from 1.24-3.06 mg/L, and the area under the time curve from 0-12 h ranged from 3.2-19.65 mg.h/L. Similar levels were noted after dose four. Gastrointestinal absorption of ciprofloxacin in tube fed critically ill patients was decreased, but well above MIC values for many pathogenic bacteria.
Cohn
S M
SM
Department of Surgery, Yale School of Medicine, New Haven, CT 06520, USA.
Sawyer
M D
MD
Burns
G A
GA
Tolomeo
C
C
Milner
K A
KA
D018806:APACHE; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D016638:Critical Illness; D004750:Enteral Nutrition; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000188:drug therapy / Q000378:metabolism
D000890:Anti-Infective Agents; D002939:Ciprofloxacin