Postoperative adjuvant locoregional chemotherapy in patients with hepatocellular carcinoma.
OBJECTIVE
Hepatocellular carcinoma (HCC) recur frequently in HCC patients with invasive factors such as vascular invasion and intrahepatic metastasis and its prevention is important in obtaining better surgical survival.


METHODS
Palliative resection with locoregional therapy for multinodular HCC was performed to prevent postoperative complications in patients with poor hepatic reserve. Disease-free survival (DFS) and survival for these patients who underwent hepatic resection for noninvasive HCC, and for invasive HCC with or without adjuvant chemotherapy were analyzed to determine the effects of adjuvant chemotherapy. Survival of palliative resection for HCC was analyzed to determine the effect of reduction surgery.


RESULTS
DFS and survival of patients with adjuvant chemotherapy was better than those of patients without adjuvant chemotherapy, but not significantly (DFS; p = 0.0508, survival; p = 0.0570), and the survival of patients without adjuvant chemotherapy was almost equal to that of patients who underwent palliative resection. Adjuvant chemotherapy was effective in improving survival, but the effect was not satisfactory.


CONCLUSIONS
Palliative resection was effective in treating multinodular HCC. Further trials are required to improve the surgical survival of patients with HCC.
Izumi
R
R
Department of Surgery, Toyama City Hospital.
Shimizu
K
K
Miyazaki
I
I
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D003287:Contrast Media; D018572:Disease-Free Survival; D004337:Drug Carriers; D004621:Embolization, Therapeutic; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007261:Infusions, Intra-Arterial; D007459:Iodized Oil / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000517:prevention & control; D015996:Survival Rate
D000970:Antineoplastic Agents; D003287:Contrast Media; D004337:Drug Carriers; D007459:Iodized Oil