title: MR imaging in the management before surgery of lobular carcinoma of the breast: correlation with pathology.
abstract: OBJECTIVE
  Our objective was to investigate the use of MR imaging in preoperative staging and characterization of lobular carcinoma.
  
  
  METHODS
  MR imaging studies and mammographic studies in 20 patients with infiltrating lobular carcinoma were evaluated and correlated with pathology findings on serially sectioned tissue. The MR images and mammograms were reviewed retrospectively by three independent examiners unaware of the clinical, imaging, and pathology findings.
  
  
  RESULTS
  The extent of disease found pathologically correlated with that predicted by MR imaging studies in 85% of patients, compared with a 32% correlation (p < .0001) with mammographic studies. Interobserver agreement on lesion morphology and extent of disease was higher for MR imaging (91% and 100%, respectively) than for mammography (64% and 91%, respectively). The retrospective MR readings did not differ from the prospective reports. No false-positive lymphadenopathy was interpreted on MR imaging. Lymph nodes having metastatic lobular carcinoma on the pathology examination were missed on MR imaging in four patients.
  
  
  CONCLUSIONS
  MR imaging is significantly more accurate than mammography in determining the extent of disease and characterizing the morphology of infiltrating lobular carcinoma. MR imaging may play a role in preoperative planning, especially when breast conservation is being considered.
authors.affiliation: Department of Radiology, Baylor University Medical Center, Dallas, TX 75246, USA.
authors.forename: G N
authors.initials: GN
authors.lastname: Rodenko
authors.forename: S E
authors.initials: SE
authors.lastname: Harms
authors.forename: J M
authors.initials: JM
authors.lastname: Pruneda
authors.forename: R S
authors.initials: RS
authors.lastname: Farrell
authors.forename: W P
authors.initials: WP
authors.lastname: Evans
authors.forename: D S
authors.initials: DS
authors.lastname: Copit
authors.forename: P A
authors.initials: PA
authors.lastname: Krakos
authors.forename: D P
authors.initials: DP
authors.lastname: Flamig
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D018275:Carcinoma, Lobular / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D015588:Observer Variation; D012189:Retrospective Studies