title: Quantitative PET measurements of regional myocardial blood flow: observations in humans with ischemic heart disease.
abstract: This review focuses on several related issues concerning positron emission tomography measurements of regional myocardial blood flow using 13-N-ammonia in humans. The effect of partial volume correction on estimates of K1, the model parameter describing myocardial blood flow, is considered. In addition a new method for computing K1 images of myocardial flow distribution is briefly described and compared to a standard method. Potential differences between K1 and equilibrium levels of 13-N-ammonia in the myocardium for estimation of myocardial blood flow are discussed also. The issue of heterogeneity of myocardial blood flow and flow reserve in normal volunteers is considered from the clinical point of view in terms of evaluation of patients with ischemic heart disease. Finally, the use of absolute measurement of adenosine-stimulated myocardial blood flow to assess physiological significance of coronary artery stenoses is addressed.
authors.affiliation: Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA.
authors.forename: H
authors.initials: H
authors.lastname: Gewirtz
authors.forename: H A
authors.initials: HA
authors.lastname: Skopicki
authors.forename: S A
authors.initials: SA
authors.lastname: Abraham
authors.forename: H
authors.initials: H
authors.lastname: Castano
authors.forename: R E
authors.initials: RE
authors.lastname: Dinsmore
authors.forename: N M
authors.initials: NM
authors.lastname: Alpert
authors.forename: A J
authors.initials: AJ
authors.lastname: Fischman
mesh_terms: D000241:Adenosine / Q000494:pharmacology; D000328:Adult; D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D013552:Swine; D014055:Tomography, Emission-Computed / Q000379:methods*; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D014665:Vasodilator Agents; D000241:Adenosine