[Hypertension and hyperuricemia].
Epidemiological studies show that serum uric acid is positively associated with blood pressure levels and that serum uric acid is also a predictor of the development of hypertension in normotensive adults. Several clinical studies revealed that insulin resistance and/or hyperinsulinaemia is associated with hypertension and higher plasma concentrations of uric acid, triglyceride and plasminogen activator inhibitor 1 and with lower HDL cholesterol concentrations. Abnormalities in membrane transport system of sodium and related ions may be associated with impared urinary excretion of uric acid in hyperuricemic patients with hypertension. Several anti-hypertensive drugs have been shown to increase urinary excretion of uric acid and thereby reduce its serum level. Strict salt restriction and weight loss may cause at least in the short-term, adverse metabolic changes including elevated uric acid levels. In hypertensive patients.
Hirai
A
A
2nd Department of Internal Medicine, Chiba University Medical School.
Saitoh
Y
Y
D000293:Adolescent; D000328:Adult; D000818:Animals; D001581:Benzothiadiazines; D001692:Biological Transport; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002462:Cell Membrane / Q000378:metabolism; D002648:Child; D004232:Diuretics; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*; D007333:Insulin Resistance; D008297:Male; D012737:Sex Factors; D012964:Sodium / Q000378:metabolism; D049993:Sodium Chloride Symporter Inhibitors / Q000009:adverse effects; D014527:Uric Acid / Q000097:blood*
D001581:Benzothiadiazines; D002121:Calcium Channel Blockers; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D014527:Uric Acid; D012964:Sodium