Oxygen tension in mouse mammary carcinomas and osteosarcomas after irradiation with reactor fission neutrons.
Investigations were made on intratumoral oxygen tension after irradiations with reactor fission neutrons using the Eppendorf-pO2-Histograph. Isotransplanted AT17-mammary carcinomas on C3H-mice and osteosarcomas OTS-64 on Balb c-mice received 2 or 6 Gy neutrons single dose. Before and at certain points of time after treatment the pO2-values were evaluated. Some tumors with initially low median pO2-values showed a short-lasting increase between 2 and 24 hours after irradiation. In the tumors with relatively high median pO2-values before irradiation the pO2 decreased to hypoxic range. A third group of tumors showed no significant changes after irradiation. None of the tumors stopped growth during the observation period.
Weissfloch
L
L
Clinic and Policlinic for Radiotherapy and Radiological Oncology, Munich, Germany.
Auberger
T
T
Senekowitsch-Schmidtke
R
R
Wagner
F M
FM
Tempel
K
K
Molls
M
M
D000230:Adenocarcinoma / Q000378:metabolism* / Q000532:radiotherapy; D000818:Animals; D015687:Cell Hypoxia; D004307:Dose-Response Relationship, Radiation; D005214:Fast Neutrons; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism* / Q000532:radiotherapy; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D012516:Osteosarcoma / Q000378:metabolism* / Q000532:radiotherapy; D010100:Oxygen / Q000032:analysis* / Q000378:metabolism; D011247:Pregnancy; D011879:Radiotherapy Dosage; D013997:Time Factors
D010100:Oxygen