[Study of chromosome painting for one rare carrier with complex translocation].
This paper reports that one rare male carrier with complex translocation, being married for eight years, made his wife consecutive seven times abortions, stillbirth and teratogenesis of early death. Using human chromosome 7 and 8-specific probe pools constructed with the technique of chromosome microdissection and PCR, we carried out chromosome painting research of the patients, and identified the karyotype was: 46, XY, -7, -8, -9, +der (7)t(7; 9) (q2200; p24), +der(8)inv ins(8; 7) (q2100; q31.2q2200), +der (9)t(9; 7) (p24; q31.2).ish der(7)t(7; 9) (wcp7+), der(8)inv ins(8; 7)(wcp7+, wcp8+), der(9)t(9; 7) (wcp7+). The technique of chromosome painting provided us an effective technique of molecular cytogenetics for the study of chromosomal abnormalities. The formation mechanism of the complex translocation of the carrier is discussed.
Fu
J
J
National Laboratory of Medical Genetics, Human Medical University, Changsha.
Xia
J
J
Long
Z
Z
Yang
Y
Y
Pan
Q
Q
Chen
S
S
Li
L
L
D000328:Adult; D006579:Heterozygote; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D014178:Translocation, Genetic