Angiotensinogen in human essential hypertension.
The candidacy of angiotensinogen for a role in the genetic basis of hypertension is supported by the observation that plasma angiotensinogen levels track with raised blood pressure through families. In addition, transgenic mice with overexpression of a rat angiotensinogen gene develop hypertension, and knockout mice with a disrupted gene and absent angiotensinogen production develop low blood pressure. There are now two studies in populations of white European origin and one in African Caribbeans providing support for a role of the angiotensinogen gene locus in human essential hypertension.
Caulfield
M
M
Department of Clinical Pharmacology, St Bartholomew's Hospital, London, UK.
Lavender
P
P
Newell-Price
J
J
Kamdar
S
S
Farrall
M
M
Clark
A J
AJ
D000808:Angiotensinogen / Q000235:genetics*; D000818:Animals; D008040:Genetic Linkage; D014644:Genetic Variation; D006801:Humans; D006973:Hypertension / Q000235:genetics*
D000808:Angiotensinogen