[Pharmacokinetics of vancomycin in neonates of postconceptional age less than or equal to 32 weeks].
The objective of the present study was to analyze the pharmacokinetic behavior of vancomycin in neonates of postconceptional age < or = 32 weeks (n = 44). The elimination of the antibiotic was influenced by the concomitant treatment with indomethacin and mechanical ventilation. Close monitoring of renal function of the neonate and vancomycin dosage individualization are mandatory when the above factors are present. Vancomycin dosage guidelines have been determined according to serum creatinine of these premature patients.
Ginovart Galiana
G
G
Unidad de Neonatología, Hospital de la Santa Creu i Sant Pau, Barcelona.
Mangues Bafalluy
M A
MA
Demestre Guasch
X
X
Farré Riba
R
R
Lopes Santos
A P
AP
Altirriba Valls
O
O
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D003404:Creatinine / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005865:Gestational Age; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology / Q000627:therapeutic use; D007231:Infant, Newborn; D007234:Infant, Premature; D012121:Respiration, Artificial; D013203:Staphylococcal Infections / Q000188:drug therapy; D014640:Vancomycin / Q000378:metabolism / Q000493:pharmacokinetics* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D014640:Vancomycin; D003404:Creatinine; D007213:Indomethacin
Comportamiento farmacocinético de la vancomicina en neonatos de edad postconcepcional < or = 32 semanas. Propuesta de una pauta de dosificación.