title: Dobutamine thallium-201 SPECT imaging for assessment of peri-infarction and remote myocardial ischemia.
abstract: This study assessed the value of dobutamine 201Tl scintigraphy for detecting significant disease of infarct-related and remote coronary arteries in myocardial infarction patients.
  
  
  METHODS
  Dobutamine (up to 40 micrograms/kg/min)/atropine (up to 1 mg) stress test in conjunction with stress-reinjection 200Tl SPECT was performed in 71 symptomatic patients with left ventricular dysfunction > 3 mo after myocardial infarction. Ischemia was defined as reversible perfusion defects.
  
  
  RESULTS
  Significant coronary artery stenosis (> or = 50% luminal diameter stenosis) was detected in all patients. Sensitivity, specificity and accuracy of regional ischemia for the diagnosis of remote coronary artery stenosis were 74% (95% Cl 63-86), 80% (Cl 70-90) and 76% (Cl 65-87), respectively. Those for infarct-related artery stenosis were 71% (Cl 60-81), 83% (Cl 75-92) and 72% (Cl 61-82), respectively. Ischemic perfusion score was higher in patients with multiversus single-vessel disease (1056 +/- 1021 versus 423 +/- 633, p < 0.01).
  
  
  CONCLUSIONS
  Dobutamine thallium scintigraphy is valuable for assessing the extent of coronary stenosis on the basis of reversible hypoperfusion in symptomatic patients late after myocardial infarction.
authors.affiliation: Thoraxcenter, University Hospital Rotterdam-Dijkzigt, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Elhendy
authors.forename: J H
authors.initials: JH
authors.lastname: Cornel
authors.forename: J R
authors.initials: JR
authors.lastname: Roelandt
authors.forename: R T
authors.initials: RT
authors.lastname: van Domburg
authors.forename: M L
authors.initials: ML
authors.lastname: Geleijnse
authors.forename: P A
authors.initials: PA
authors.lastname: Hoeymans
authors.forename: A E
authors.initials: AE
authors.lastname: Reijs
authors.forename: F J
authors.initials: FJ
authors.lastname: TenCate
authors.forename: M M
authors.initials: MM
authors.lastname: Ibrahim
authors.forename: P M
authors.initials: PM
authors.lastname: Fioretti
mesh_terms: D001285:Atropine; D003326:Coronary Circulation; D003327:Coronary Disease / Q000000981:diagnostic imaging; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D004280:Dobutamine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology; D012680:Sensitivity and Specificity; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging
chemical_list: D013794:Thallium Radioisotopes; D004280:Dobutamine; D001285:Atropine