title: Tumor angiogenesis and expression of thymidine phosphorylase/platelet derived endothelial cell growth factor in human gastric carcinoma.
abstract: To investigate the relationship between tumor angiogenesis and the expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/dThdPase) and between patients' survival and the expression of PD-ECGF/ dThdPase in human gastric carcinoma tissues, we performed immunohistochemical studies with anti-PD-ECGF/dThdPase and anti-CD34 monoclonal antibodies. Out of 154 gastric carcinoma tissue samples, 61 (40%) were evaluated as PD-ECGF/ dThdPase-positive. The expression of PD-ECGF/dThdPase was significantly associated with the intratumoral microvessel counts (P < 0.0001) and the incidence of hematogenous metastasis (P < 0.05). Intratumoral vessel counts were significantly correlated with overall survival of 154 patients (P < 0.000001). Cox proportional hazards model showed that tumor vasculature was an independent and strong prognostic variable. However, the prevalence of the expression of PD-ECGF did not associate the overall survival. We suggest that expression of PD-ECGF/dThdPase plays a role in the promotion of angiogenesis in human gastric carcinomas, without any definite influence on patient's survival.
authors.affiliation: Second Department of Surgery, Fukui Medical School, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Tanigawa
authors.forename: H
authors.initials: H
authors.lastname: Amaya
authors.forename: M
authors.initials: M
authors.lastname: Matsumura
authors.forename: Y
authors.initials: Y
authors.lastname: Katoh
authors.forename: A
authors.initials: A
authors.lastname: Kitaoka
authors.forename: T
authors.initials: T
authors.lastname: Aotake
authors.forename: T
authors.initials: T
authors.lastname: Shimomatsuya
authors.forename: O A
authors.initials: OA
authors.lastname: Rosenwasser
authors.forename: M
authors.initials: M
authors.lastname: Iki
mesh_terms: D000230:Adenocarcinoma / Q000098:blood supply / Q000201:enzymology*; D000368:Aged; D015153:Blotting, Western; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D010982:Platelet-Derived Growth Factor / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000098:blood supply / Q000201:enzymology*; D016019:Survival Analysis; D013939:Thymidine Phosphorylase / Q000378:metabolism*
chemical_list: D010982:Platelet-Derived Growth Factor; D013939:Thymidine Phosphorylase