Cardiac valvular disease in scleroderma and systemic lupus erythematosus/scleroderma overlap associated with antiphospholipid antibodies.
We describe 2 cases with positive antiphospholipid antibodies (aPL); one with limited scleroderma associated with aortic valve vegetation, the 2nd with systemic lupus erythematosus/scleroderma overlap with recurrent venous thrombosis, pulmonary emboli, hemolytic anemia, and severe mitral regurgitation requiring valve replacement.
Penmetcha
M
M
Division of Rheumatology, Rush-Presbyterian-St. Lukes Medical Center, Chicago, Illinois 60612, USA.
Rosenbush
S W
SW
Harris
C A
CA
D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000032:analysis*; D004452:Echocardiography; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology*; D008297:Male; D008944:Mitral Valve Insufficiency / Q000150:complications* / Q000000981:diagnostic imaging; D012594:Scleroderma, Localized / Q000150:complications* / Q000276:immunology*
D017152:Antibodies, Antiphospholipid