title: Centration and fixation of posterior chamber intraocular lenses in eyes with pseudoexfoliation syndrome. An analysis of explanted autopsy eyes.
abstract: Pseudoexfoliation syndrome is an important risk factor in cataract surgery. We examined decentration of posterior chamber intraocular lenses in a series of 24 autopsy eyes with pseudoexfoliation syndrome that had undergone cataract surgery and intraocular lens implantation. The results were compared to a control group of 25 normal autopsy eyes that matched the pseudoexfoliation collection for age distribution, implant duration and further anatomical parameters. The mean lens decentration in all pseudoexfoliation eyes (0.75 +/- 0.38 mm) was significantly higher than in the control group (0.40 +/- 0.29 mm) (p = 0.0008). Analysis of subgroups with symmetrical bag/bag fixated intraocular lenses showed a significantly higher decentration in the pseudoexfoliation group (p = 0.04). The main reason for decentration was a decentration of the entire capsular bag in pseudoexfoliative eyes (p = 0.001), which was related to zonular weakness and damage. The results indicate that in patients with pseudoexfoliation syndrome alternative fixation sites, like sulcus or transscleral fixation, should also be considered.
authors.affiliation: Storm Eye Institute, Department of Ophthalmology and Pathology, Medical University of South Carolina, Charleston, USA.
authors.forename: G U
authors.initials: GU
authors.lastname: Auffarth
authors.forename: K
authors.initials: K
authors.lastname: Tsao
authors.forename: T A
authors.initials: TA
authors.lastname: Wesendahl
authors.forename: A
authors.initials: A
authors.lastname: Sugita
authors.forename: D J
authors.initials: DJ
authors.lastname: Apple
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017889:Exfoliation Syndrome / Q000150:complications / Q000473:pathology / Q000601:surgery*; D005548:Foreign-Body Migration / Q000209:etiology / Q000473:pathology; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000601:surgery; D007910:Lenses, Intraocular; D008855:Microscopy, Electron, Scanning; D011183:Postoperative Complications; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome