Laboratory evaluation of sensitivity of three keratinophilic fungi to some vicolides.
Four vicolides (sesquiterpenoides) isolated from Vicoa indica were evaluated against three keratinophilic fungi, viz., Microsporum gypseum, Chrysosporium tropicum, and Trichophyton terrestris. All the test fungi were found to be sensitive to vicolides. Vicolides A and C showed the maximum efficacy while B and D exhibited moderate activity. The Minimum Inhibitory Concentration (MIC) was observed in the range of 15.62-125 micrograms. The most sensitive fungus tested was C. tropicum followed by T. terrestris and M. gypseum.
Rai
M K
MK
Department of Botany, Danielson College, Chhindwara, India.
Vasanth
S
S
D002455:Cell Division / Q000187:drug effects; D002725:Chloroform / Q000737:chemistry; D003114:Colony-Forming Units Assay; D005658:Fungi / Q000166:cytology / Q000187:drug effects*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D013045:Species Specificity
D010936:Plant Extracts; D012717:Sesquiterpenes; D002725:Chloroform