Evaluation of ischemia after ESWL: detection of free oxygen radical scavenger enzymes in renal parenchyma subjected to high-energy shock waves.
To evaluate the degree of ischemic formation at the tissue level after high-energy shock wave (HESW) application in a time- and dose-dependent manner, an experimental study in rabbits was performed. Following varying numbers of HESWs (1,000-2,000-3,000 shock waves) under fluoroscopic localization, treated kidneys were removed, by assessing tissue concentrations of two different free-radical scavenger enzymes (superoxide dismutase and catalase) the degree of formation of free oxygen radicals (i.e. ischemia) was evaluated. Evaluation of our results showed a statistically significant (p < 0.05) decrease in tissue scavenger enzyme levels (i.e. formation of free oxygen radicals) after 24 h following HESW application. However, results obtained 7 days after ESWL demonstrated disappearance of ischemia with normalization of tissue enzyme levels (p > 0.05).
Sarica
K
K
Department of Urology, Ibn-i Sina Hospital, University of Ankara Medical School, Turkey.
Koşar
A
A
Yaman
O
O
Bedük
Y
Y
Durak
I
I
Göğüş
O
O
Kavukçu
M
M
D000818:Animals; D002374:Catalase / Q000378:metabolism*; D005609:Free Radicals; D007511:Ischemia / Q000201:enzymology* / Q000209:etiology / Q000378:metabolism; D007668:Kidney / Q000098:blood supply* / Q000201:enzymology*; D008096:Lithotripsy; D011817:Rabbits; D013482:Superoxide Dismutase / Q000378:metabolism*
D005609:Free Radicals; D002374:Catalase; D013482:Superoxide Dismutase