Effect of growth hormone (GH) therapy on parathyroid hormone metabolism in a girl with GH deficient short stature and chronic renal failure.
During GH treatment of a 14 year-old girl with chronic renal failure and short stature, she developed hyperparathyroidism which was successfully treated by the oral agent 26,27-F6-1, 25-dihydroxyvitamin D3 (26,27-F6-1,25(OH)2vit D3). It is hypothesized that the elevation of serum PTH level was induced either by the rise in phosphorus levels induced by GH or by a direct stimulatory effect of IGF-I on PTH production. This seems to be the first report of this kind.
Fujisawa
Y
Y
Division of Pediatrics, Ehime Prefectural Central Hospital, Japan.
Kida
K
K
D000293:Adolescent; D001827:Body Height; D002117:Calcitriol / Q000031:analogs & derivatives / Q000627:therapeutic use; D002118:Calcium / Q000097:blood; D005260:Female; D019382:Human Growth Hormone / Q000009:adverse effects* / Q000172:deficiency* / Q000627:therapeutic use; D006801:Humans; D006961:Hyperparathyroidism / Q000139:chemically induced* / Q000188:drug therapy; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D010281:Parathyroid Hormone / Q000097:blood; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010758:Phosphorus / Q000097:blood; D005466:Fluorocarbons
D002117:Calcitriol; D002118:Calcium; D019382:Human Growth Hormone; D010281:Parathyroid Hormone; D010758:Phosphorus; C040488:26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3; D005466:Fluorocarbons