[Attitudes towards screening and prevention of breast and ovarian cancers with hereditary predisposition. Survey by female gynecologists in the north of France].
Search for mutations of BRCA1 in women at hereditary risk for cancer is now possible. We asked the female gynaecologists of our county (north of France) their opinion about the search of a mutation of BRCA1 if they had a familial risk of breast cancer. Our aim was to obtain the opinion of informed women about their willingness to do the test for themselves and about the consequences they should accept. One hundred and eighty-three women received a questionnaire by post. The response rate was 56.3%. Twenty-four percent of the responders had a first degree relative with breast cancer. Most of the responders (87.4%; IC 95%: 81-93.8) would ask for the search of a mutation of BRCA1. The percentage of women who would accept the test is smaller for the women who have a first degree relative with breast cancer (72.0% vs 92.3%; P = 0.02). The reasons given to do the test were a better screening or prevention (69.7%) and the knowledge of a personal risk (49.4%). For breast cancer, 93.2% (95% CI: 88.4-98) would accept a screening protocol, 30.1% (CI: 21.3-38.9) would accept a prophylactic bilateral mastectomy. For ovarian cancer, 93.2% (CI: 88.4-98) would accept the screening, 52.4% (CI: 42.8-62) would accept a prophylactic ovariectomy. In conclusion, most of the informed women would ask for the test and the surgical options for reducing the risk of cancer are not absolutely rejected. Of course, only future studies will state precisely the choice of truly implicated women.
Vennin
P
P
Centre Oscar-Lambret, Lille, France.
Giard
S
S
Julian-Reynier
C
C
Sailly
F
F
Peyrat
J P
JP
Fournier
C
C
Eisinger
F
F
Sobol
H
H
D000328:Adult; D000368:Aged; D001291:Attitude of Health Personnel; D019313:BRCA1 Protein / Q000235:genetics; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000517:prevention & control; D003657:Decision Making; D004198:Disease Susceptibility; D005260:Female; D005602:France / Q000453:epidemiology; D005820:Genetic Testing; D006306:Health Surveys; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000517:prevention & control; D010822:Physicians, Women / Q000523:psychology*; D011795:Surveys and Questionnaires
D019313:BRCA1 Protein
Attitudes envers le dépistage et la prévention des cancers mammaires et ovariens avec prédisposition héréditaire. Enquête auprès des femmes gynécologues de la région Nord de la France.