Recovery of the hematopoietic system by Si-Jun-Zi-Tang in whole body irradiated mice.
The herbal formulation Si-Jun-Zi-Tang reduced the decrease of leukocytes, erythrocytes, thrombocytes and hematocrit in irradiated mice. In general, its protection was more effective in leukocytes and thrombocytes than other hematocytes. Protection of bone marrow stem cells by Si-Jun-Zi-Tang was markedly enhanced by increased radiotolerance under the dose ranging from 0 to 5 Gy. This increased radiotolerance led to a prolonged shoulder in the survival curve but did not influence the D0 value. Si-Jun-Zi-Tang exerted a beneficial effect on clinical syndromes such as anemia. From the results in this study, we concluded preliminarily that the most effective concentration with least toxicity was about 20 mg/20 g body weight. At this dose, levels of leukocytes as well as thrombocytes were enhanced significantly after chi-irradiation. Elevation of erythrocytes and hematocrits could also be found but was not significant.
Hsu
H Y
HY
School of Technology for Medical Sciences, Kaohsiung Medical College, Taiwan, R.O.C.
Yang
J J
JJ
Lian
S L
SL
Ho
Y H
YH
Lin
C C
CC
D000818:Animals; D001772:Blood Cell Count / Q000187:drug effects / Q000528:radiation effects; D001792:Blood Platelets / Q000187:drug effects / Q000528:radiation effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects / Q000528:radiation effects; D006400:Hematocrit; D006413:Hematopoietic System / Q000187:drug effects* / Q000528:radiation effects*; D007962:Leukocytes / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D014916:Whole-Body Irradiation
D004365:Drugs, Chinese Herbal; D011837:Radiation-Protective Agents