Glyceryl trinitrate enhances nitric oxide mediated perfusion within the equine hoof.
Laminitis, a microvascular disease of the equine hoof leads to severe lameness. Exogenous iv 1-arginine and transdermal nitric oxide donors, such as GTN, applied to the pasterns improve lameness during acute laminitis. Near Infrared spectroscopy in an earlier study showed haemostasis and ischaemia in the hoof during acute laminitis, both were alleviated by 1-arginine. Quantitative NIRS in the present study shows that transdermal GTN increases blood flow in the equine hoof. It is concluded that glyceryl trinitrate enhances nitric oxide mediated perfusion within the equine hoof in normal and chronically laminitic horses and ponies.
Hinckley
K A
KA
Department of Animal and Plant Sciences, University of Sheffield.
Fearn
S
S
Howard
B R
BR
Henderson
I W
IW
D000279:Administration, Cutaneous; D000818:Animals; D005260:Female; D005534:Foot Diseases / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D006724:Hoof and Claw / Q000098:blood supply* / Q000378:metabolism; D006734:Horse Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D006736:Horses; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D005996:Nitroglycerin / Q000008:administration & dosage* / Q000627:therapeutic use; D012039:Regional Blood Flow / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000627:therapeutic use
D014665:Vasodilator Agents; D009569:Nitric Oxide; D005996:Nitroglycerin