title: [Immunotoxicity assessment in the preclinical study of biologically active compounds].
abstract: The immunotropic action of different drugs was considered on the basis of the modern theory of immunity (theory of network regulation). The immunosuppression and immunostimulation effects were analyzed retrospectively, as well as "disordered" immunity under the action of drugs. A systemic immunomodulated action of different drugs was postulated. Methodical recommendations for the preclinical estimation of immunotoxicity were generalized. A new protocol was proposed, concerning the examination of drug effects on the immune system.
authors.forename: B S
authors.initials: BS
authors.lastname: Uteshev
authors.forename: E V
authors.initials: EV
authors.lastname: Arzamastsev
mesh_terms: D000276:Adjuvants, Immunologic / Q000633:toxicity*; D000818:Animals; D015551:Autoimmunity / Q000187:drug effects; D007107:Immune System / Q000187:drug effects* / Q000276:immunology; D007109:Immunity / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000633:toxicity*; D012189:Retrospective Studies
chemical_list: D000276:Adjuvants, Immunologic; D007166:Immunosuppressive Agents
vernacular_title: Ob otsenke immunotoksichnosti pri doklinicheskom izuchenii biologicheski aktivnykh soedineniĭ.