title: Dihydroorotate dehydrogenase is a target for the biological effects of leflunomide.
authors.affiliation: Hoechst Marion Roussel, Covingham, Swindon, UK.
authors.forename: R A
authors.initials: RA
authors.lastname: Williamson
authors.forename: C M
authors.initials: CM
authors.lastname: Yea
authors.forename: P A
authors.initials: PA
authors.lastname: Robson
authors.forename: A P
authors.initials: AP
authors.lastname: Curnock
authors.forename: S
authors.initials: S
authors.lastname: Gadher
authors.forename: A B
authors.initials: AB
authors.lastname: Hambleton
authors.forename: K
authors.initials: K
authors.lastname: Woodward
authors.forename: J M
authors.initials: JM
authors.lastname: Bruneau
authors.forename: P
authors.initials: P
authors.lastname: Hambleton
authors.forename: S
authors.initials: S
authors.lastname: Spinella-Jaegle
authors.forename: P
authors.initials: P
authors.lastname: Morand
authors.forename: O
authors.initials: O
authors.lastname: Courtin
authors.forename: C
authors.initials: C
authors.lastname: Sautés
authors.forename: R
authors.initials: R
authors.lastname: Westwood
authors.forename: T
authors.initials: T
authors.lastname: Hercend
authors.forename: E A
authors.initials: EA
authors.lastname: Kuo
authors.forename: E
authors.initials: E
authors.lastname: Ruuth
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002478:Cells, Cultured; D000090722:Dihydroorotate Dehydrogenase; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007425:Intracellular Membranes / Q000201:enzymology; D007555:Isoxazoles / Q000494:pharmacology*; D000077339:Leflunomide; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects / Q000201:enzymology* / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D008861:Microsomes / Q000201:enzymology; D008928:Mitochondria / Q000201:enzymology; D008969:Molecular Sequence Data; D010088:Oxidoreductases / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D044925:Oxidoreductases Acting on CH-CH Group Donors; D010446:Peptide Fragments / Q000737:chemistry; D051381:Rats; D017386:Sequence Homology, Amino Acid; D013154:Spleen / Q000276:immunology
chemical_list: D000090722:Dihydroorotate Dehydrogenase; D007166:Immunosuppressive Agents; D007555:Isoxazoles; D010446:Peptide Fragments; D010088:Oxidoreductases; D044925:Oxidoreductases Acting on CH-CH Group Donors; D000077339:Leflunomide