Velocity-dependent ankle torque in the normal rat.
We evaluated the velocity-dependent ankle torque and associated activity of the ankle extensor muscle stretch reflexes in normal rats. A 287% increase in velocity-dependent ankle torque was observed at the highest velocity tested compared with the lowest velocity. Low velocity torques were minimally altered during general anesthesia that depressed EMG activity by up to 90%. However, velocity-dependent torque during higher velocity ankle rotations (306-612 degrees s-1 correlated with parallel increases in EMG magnitude recorded from the triceps surae muscles. General anesthesia (pentobarbital) abolished 61% of the velocity-dependent ankle torque at 612 degrees s-1. We conclude that ankle torque and ankle extensor muscle activity display velocity enhancement over a broad range. These observations indicate that protocols designed to assess ankle torque in the rat should use instrumentation to produce a broad range of velocities up to at least 600 degrees s-1.
Thompson
F J
FJ
Dept. of Neuroscience, University of Florida Health Sciences Center, Gainesville 32610, USA.
Browd
C R
CR
Carvalho
P M
PM
Hsiao
J
J
D000768:Anesthesia, General; D000818:Animals; D004576:Electromyography; D018482:Muscle, Skeletal / Q000502:physiology; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D012026:Reflex, Stretch / Q000187:drug effects; D013643:Tarsus, Animal / Q000502:physiology*; D019415:Torque
D010424:Pentobarbital