The involvement of nitric oxide (NO) in the CGRP-induced behavior of rats.
The possible role of nitric oxide (NO) in CGRP-induced passive avoidance, active avoidance, and open field behavior was tested in rats. A specific NO synthase inhibitor, N omega-nitro-L-arginine (L-NA), was used to disrupt NO synthesis. ICV administration of 5 micrograms of L-NA reversed the action of CGRP in passive and active avoidance tests. In an open field, L-NA prevented the action of CGRP on locomotion and grooming. The inactive isomer D-NA had no effect on behavior of animals. The data suggest that NO might contribute to CGRP-induced behavior in rats.
Kovács
A
A
Department of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Telegdy
G
G
Tóth
G
G
Penke
B
B
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000502:physiology*; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D006120:Grooming / Q000187:drug effects / Q000502:physiology*; D007275:Injections, Intravenous; D008124:Locomotion / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D019335:Nitroarginine / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar
D004791:Enzyme Inhibitors; D019335:Nitroarginine; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D015740:Calcitonin Gene-Related Peptide