A new blood compatible and permselective hollow fiber membrane for hemodialysis.
The authors have prepared a blood compatible and highly permselective hemodialysis membrane composed of polyether segmented nylon. This block copolymer was synthesized by polycondensation of bis-3-aminopropyl-poly(tetramethylene oxide) (PTMO) and poly(imino-1,3-bismethyl-cyclohexyl-iminoisophtharoyl) (NyBl) prepolymer obtained by polycondensation of 1,3-bis(aminomethyl)cyclohexane (B) and isophthalic acid (I). The molecular weight (MW) calculated from the number of end-groups was 16,000-21,000. In vitro blood compatibility was evaluated in terms of platelet adhesion onto the surface. PTMO-NyBl surfaces showed excellent platelet adhesion preventing properties. The PTMO-NyBl hollow fiber membrane was obtained by a dry-wet spinning process. The membranes had higher permeability coefficients for macromolecules ranging from MW 10,000 to 20,000 than polysulfone hollow fiber membrane (PS membrane), and had acceptably low albumin permeability for use as a dialysis membrane. The ex vivo blood compatibilities of PTMO-NyBl membrane and PS membrane were investigated by extracorporeal circulation in a pig model. The PTMO-NyBl membrane gave excellent results when assessing hemodialysis leukopenia, oxidative burst, and free platelet count decrease.
Yamashita
S
S
Terumo Corporation, Kanagawa, Japan.
Mochizuki
A
A
Nakazaki
T
T
Seita
Y
Y
Sawamoto
J
J
Endo
F
F
Yui
N
N
Ogata
N
N
Kataoka
K
K
Okano
T
T
Sakurai
Y
Y
D001672:Biocompatible Materials / Q000592:standards*; D001792:Blood Platelets / Q000166:cytology; D005434:Flow Cytometry; D006801:Humans; D008567:Membranes, Artificial; D008970:Molecular Weight; D009757:Nylons / Q000737:chemistry / Q000378:metabolism; D010795:Phthalic Acids / Q000737:chemistry; D010976:Platelet Count; D011091:Polyesters / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D011108:Polymers; D006435:Renal Dialysis; D016897:Respiratory Burst / Q000187:drug effects; D013923:Thromboembolism / Q000517:prevention & control
D001672:Biocompatible Materials; D008567:Membranes, Artificial; D009757:Nylons; D010795:Phthalic Acids; D011091:Polyesters; D011108:Polymers; C059768:isophthalate