title: A review of nonparametric tests for changepoint problems, with application to a recombinant drug therapy clinical trial.
abstract: We review general classes of nonparametric tests for the changepoint problem. We extend these tests to analyze the results of a clinical trial examining whether pretreatment of surgical patients with erythropoietin reduces their subsequent need for blood transfusions. We find a changepoint in baseline hemoglobin levels, below which pretreatment with erythropoietin appears particularly beneficial relative to placebo.
authors.affiliation: Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Koziol
authors.forename: S C
authors.initials: SC
authors.lastname: Wu
mesh_terms: D004311:Double-Blind Method; D004358:Drug Therapy / Q000379:methods; D004921:Erythropoietin / Q000627:therapeutic use; D006454:Hemoglobins / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008432:Mathematical Computing; D016032:Randomized Controlled Trials as Topic; D011994:Recombinant Proteins / Q000627:therapeutic use; D013223:Statistics as Topic / Q000379:methods*
chemical_list: D006454:Hemoglobins; D011994:Recombinant Proteins; D004921:Erythropoietin