title: A unique genomic sequence in the Wolf-Hirschhorn syndrome [WHS] region of humans is conserved in the great apes.
abstract: The Wolf-Hirschhorn syndrome (WHS) is caused by a partial deletion in the short arm of chromosome 4 band 16.3 (4p 16.3). A unique-sequence human DNA probe (39 kb) localized within this region has been used to search for sequence homology in the apes' equivalent chromosome 3 by FISH-technique. The WHS loci are conserved in higher primates at the expected position. Nevertheless, a control probe, which detects alphoid sequences of the pericentromeric region of humans, is diverged in chimpanzee, gorilla, and orangutan. The conservation of WHS loci and divergence of DNA alphoid sequences have further added to the controversy concerning human descent.
authors.affiliation: Division of Genetics, Long Island College Hospital, SUNY Health Science Center, Brooklyn 11201, USA.
authors.forename: S T
authors.initials: ST
authors.lastname: Tarzami
authors.forename: A M
authors.initials: AM
authors.lastname: Kringstein
authors.forename: R A
authors.initials: RA
authors.lastname: Conte
authors.forename: R S
authors.initials: RS
authors.lastname: Verma
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D000818:Animals; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D014644:Genetic Variation; D006071:Gorilla gorilla / Q000235:genetics; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D002679:Pan troglodytes / Q000235:genetics; D011148:Pongo pygmaeus / Q000235:genetics