The N-terminal alternately spliced regions of PDE4A cAMP-specific phosphodiesterases determine intracellular targeting and regulation of catalytic activity.
Houslay
M D
MD
Division of Biochemistry and Molecular Biology, University of Glasgow, Scotland, U.K.
D015105:3',5'-Cyclic-AMP Phosphodiesterases; D015106:3',5'-Cyclic-GMP Phosphodiesterases; D017398:Alternative Splicing; D000818:Animals; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D054707:Cyclic Nucleotide Phosphodiesterases, Type 6; D004789:Enzyme Activation; D005136:Eye Proteins / Q000378:metabolism; D007700:Kinetics; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D051381:Rats; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D018909:src Homology Domains
D005136:Eye Proteins; D010727:Phosphoric Diester Hydrolases; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D015106:3',5'-Cyclic-GMP Phosphodiesterases; D054707:Cyclic Nucleotide Phosphodiesterases, Type 6