Nonresponse to hepatitis B vaccines and the kinetics of anti-HBs production.
No empirical data are available for the anti-HBs title required for protection against infection with the hepatitis B virus (HBV), but nonresponders to hepatitis B vaccines remain susceptible to infection. There may be an unexplained qualitative difference between hyporesponders and true nonresponders, but there is a clear association with HLA haplotypes. There is no evidence for silent infection with HBV in nonresponders.
Zuckerman
J N
JN
Academic Unit of Travel Medicine and Vaccines, Royal Free Hospital School of Medicine, London, United Kingdom.
D000276:Adjuvants, Immunologic; D004198:Disease Susceptibility; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D006239:Haplotypes; D006509:Hepatitis B / Q000276:immunology* / Q000517:prevention & control; D006510:Hepatitis B Antibodies / Q000096:biosynthesis*; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006801:Humans; D007700:Kinetics; D014611:Vaccination
D000276:Adjuvants, Immunologic; D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines