[Rubomycin Q1--an anthracycline metabolite from Streptomyces coeruleorubidus 2679, a strain producing rubomycin C].
In the programme of screening of biologically active secondary metabolites produced by Streptomyces coeruleorubidus 2679 a new reddish-violet component (rubomycin Q1) with antibacterial and cytotoxic activity was isolated from the culture fluid of the organism. Some physico-chemical and biological properties of a chromatographically pure rubomycin Q1 were investigated. It was shown with the use of 1H NMR, UV, IR and mass spectrometry that rubomycin Q1 was an anthracycline antibiotic (9,10-anhydro-13-desoxycarminomycin).
Fedorova
G B
GB
Golova
T P
TP
Arkhangel'skaia
N M
NM
Lazhko
E I
EI
Abramova
E A
EA
Bychkova
O P
OP
Polunin
A D
AD
Katrukha
G S
GS
D000903:Antibiotics, Antineoplastic / Q000032:analysis* / Q000096:biosynthesis / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D003470:Culture Media; D003630:Daunorubicin / Q000031:analogs & derivatives / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry; D015394:Molecular Structure; D011522:Protons; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D003470:Culture Media; D011522:Protons; D003630:Daunorubicin
Rubomitsin Q1--antratsiklinovyĭ metabolit iz rubomitsin c-produtsiruiushchego shtamma Streptomyces coeruleorubidus 2679.