[Age-related changes in concentrations of ferritin, glyeosylated ferritin, and non-glycosylated ferritin].
We studied age-related changes in the concentrations in serum of ferritin, glycosylated ferritin, and non-glycosylated ferritin. The concentrations were determined in 95 healthy subjects: 39 men and 56 women, aged from 22 to 94 years. In the men, age correlated significantly with serum ferritin (r = 0.332, p < 0.05) and non-glycosylated serum ferritin (r = 0.628, p < 0.001) but not with glycosylated serum ferritin. In the women, age correlated significantly with serum ferritin (r = 0.456, p < 0.001), non-glycosylated serum ferritin (r = 0.439, p < 0.001), and glycosylated serum serum ferritin (r = 0.415, p < 0.01). The ratio of glycosylated serum ferritin to serum ferritin correlated negatively with age both in men and in women (men: r = -0.661, p < 0.001; women: r = -0.411, p < 0.01). Serum non-glycosylated ferritin levels were higher in older men. Both serum glycosylated ferritin and non-glycosylated ferritin levels were higher in older women, but this phenomenon was more pronounced with respect to the non-glycosylated form. These results suggest that hyperferritinemia in the elderly is mainly caused by an increase in the concentration of non-glycosylated ferritin, both in men and in women.
Yamashita
N
N
Division of Geriatric Medicine, Nippon Medical School.
Oba
K
K
Nakano
H
H
Metori
S
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D005260:Female; D005293:Ferritins / Q000031:analogs & derivatives* / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D006023:Glycoproteins
D005293:Ferritins; C051036:glycosylated ferritin; D006023:Glycoproteins