Enhancement of class II-restricted T cell responses by costimulatory NK receptors for class I MHC proteins.
An important feature of the human immune system is the ability of T cells to respond to small quantities of antigen. Class II major histocompatibility complex (MHC)-restricted T cells that expressed a costimulatory natural killer (NK) cell receptor for class I MHC proteins were cloned. In the presence of low doses of superantigen, the proliferative response of these T cell clones was three- to ninefold greater when the T cells were costimulated by way of the NK receptor. Thus, the action of costimulatory NK receptors on T cells may play a significant role in initiating and sustaining immune responses.
Mandelboim
O
O
Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA. jlstrom@fas.harvard.edu
Davis
D M
DM
Reyburn
H T
HT
Valés-Gómez
M
M
Sheu
E G
EG
Pazmany
L
L
Strominger
J L
JL
D001402:B-Lymphocytes / Q000276:immunology; D002460:Cell Line; D002999:Clone Cells; D006680:HLA Antigens / Q000276:immunology; D015236:HLA-C Antigens / Q000276:immunology; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D011971:Receptors, Immunologic / Q000276:immunology*; D018089:Superantigens / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014162:Transfection
D006680:HLA Antigens; D015236:HLA-C Antigens; C039966:HLA-C*04 antigen; C040178:HLA-C*70 antigen; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D011971:Receptors, Immunologic; D018089:Superantigens; C098615:p50 natural killer cell receptor