Micronucleus induction by diuron in mouse bone marrow.
Diuron, a widely used substituted urea herbicide, induced the formation of micronuclei in bone marrow cells of Swiss mice. A single i.p. dose of 340 mg/kg b.w. diuron which is maximum tolerated dose (MTD) increased significantly the number of micronuclei at 30 h and 48 h time period. The dose of 170 mg/kg b.w. also induced the micronuclei formation in the above time period. However, a dose of 85 mg/kg b.w. was ineffective at the time periods studied. No induction of micronuclei was observed at 72 h time period after all the doses of diuron studied as compared to the solvent control. The diuron-induced frequency of micronucleated erythrocytes was independent of the sex of the test animals.
Agrawal
R C
RC
Industrial Toxicology Research Centre, Lucknow, India.
Kumar
S
S
Mehrotra
N K
NK
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D003520:Cyclophosphamide / Q000633:toxicity; D004237:Diuron / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D005260:Female; D006540:Herbicides / Q000008:administration & dosage / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects*; D015162:Micronucleus Tests
D006540:Herbicides; D003520:Cyclophosphamide; D004237:Diuron