title: Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons.
abstract: Specific families of transcription factors mediate events in the sequential maturation of distinct neuronal phenotypes. Members of one such family, the class IV POU domain transcription factor Brn-3.0, and two highly related factors Brn-3.1 and Brn-3.2, are differentially expressed in the developing and mature mammalian nervous system. The expression pattern of Brn-3.0 suggested that it has an important role in the development of sensory ganglia, as well as red nucleus, inferior olive, and nucleus ambiguus. Analysis of mice null for the Brn-3.0 locus shows that Brn-3.0 is required for the survival of subpopulations of proprioceptive, mechanoreceptive and nociceptive sensory neurons, where deletion of the gene affects neurotrophin and neurotrophin-receptor gene expression. Deletion of Brn-3.0 also alters either differentiation, migration or survival of specific central neuronal populations.
authors.affiliation: Howard Hughes Medical Institute, University of California, San Diego, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: McEvilly
authors.forename: L
authors.initials: L
authors.lastname: Erkman
authors.forename: L
authors.initials: L
authors.lastname: Luo
authors.forename: P E
authors.initials: PE
authors.lastname: Sawchenko
authors.forename: A F
authors.initials: AF
authors.lastname: Ryan
authors.forename: M G
authors.initials: MG
authors.lastname: Rosenfeld
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics; D002454:Cell Differentiation; D002470:Cell Survival; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000502:physiology; D017950:Ganglia, Sensory / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D015870:Gene Expression; D018390:Gene Targeting; D008526:Medulla Oblongata / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D051379:Mice; D009046:Motor Neurons / Q000166:cytology* / Q000378:metabolism; D009414:Nerve Growth Factors / Q000502:physiology; D009475:Neurons, Afferent / Q000166:cytology* / Q000378:metabolism; D009847:Olivary Nucleus / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D020801:Receptor, Ciliary Neurotrophic Factor; D020800:Receptor, Nerve Growth Factor; D020812:Receptor, trkC; D017475:Receptors, Nerve Growth Factor / Q000235:genetics; D012012:Red Nucleus / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D013234:Stem Cells; D050818:Transcription Factor Brn-3; D050819:Transcription Factor Brn-3A; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D004268:DNA-Binding Proteins; D009414:Nerve Growth Factors; C494189:Pou4f1 protein, mouse; D020801:Receptor, Ciliary Neurotrophic Factor; D020800:Receptor, Nerve Growth Factor; D017475:Receptors, Nerve Growth Factor; D050818:Transcription Factor Brn-3; D050819:Transcription Factor Brn-3A; D014157:Transcription Factors; D020794:Receptor Protein-Tyrosine Kinases; D020812:Receptor, trkC