title: A retrospective study on the effectiveness of oral acyclovir to prevent herpes simplex recurrence in corneal grafts.
abstract: OBJECTIVE
  A retrospective study of the effectiveness of prophylactic acyclovirn to prevent recurrent infections after penetrating keratoplasty for herpetic macula.
  
  
  METHODS
  Follow-up data of 22 patients who where treated prophilactically with oral acyclovir (2 x 400 mg for the first three months after keratoplasy) and of 19 control patients were compared. All patients were operated between 1989-1991 after being free of recurrent Herpes simplex virus (HSV) infections for a minimal period of six months. Survival was defined as the probability of being free of HSV recurrence.
  
  
  RESULTS
  The hazard ratio calculated for the data of a 24 month follow-up was 0.66 (95%Cl: 0.47, 3.8). Survival probabilities at six months were 0.95 for the prophylaxis and 0.74 for the control group (95%Cl of the difference: 0.07, 0.37); after 12 months these proportions were 0.72 and 0.54 respectively (95% Cl: -0.13, 0.47).
  
  
  CONCLUSIONS
  In concordance with former studies we conclude that acyclovir may be effective as a prophylaxis in this category of patients. The probability of being free from recurrence was significantly different after six months but not after twelve, possibly indicating that the period of prophylaxis was too short.
authors.affiliation: Department of Cornea and External Disease, Eye Hospital Rotterdam, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: van Rooij
authors.forename: W J
authors.initials: WJ
authors.lastname: Rijneveld
authors.forename: L J
authors.initials: LJ
authors.lastname: Remeijer
authors.forename: W H
authors.initials: WH
authors.lastname: Beekhuis
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use*; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016039:Corneal Transplantation; D005260:Female; D006561:Herpes Simplex / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies
chemical_list: D000212:Acyclovir