Metabolism in vivo of 1-nitropyrene, an environmental pollutant, in fish.
The in vivo metabolism of 1-nitropyrene, an important environmental pollutant, was examined in fish, focusing on nitroreduction followed by acylation. When goldfish were bathed in a solution of 1-nitropyrene or its reduction product, 1-aminopyrene, one or two metabolites were isolated from the solution, respectively. The former metabolite was identified as 1-aminopyrene and the latter two metabolites as 1-acetylaminopyrene and 1-formylaminopyrene by comparing their mass and UV spectra, and their behaviors in HPLC and TLC, with those of authentic samples.
Kitamura
S
S
Institute of Pharmaceutical Science, Hiroshima University School of Medicine, Japan.
Tatsumi
K
K
D000818:Animals; D001711:Biotransformation; D004785:Environmental Pollutants / Q000378:metabolism*; D006054:Goldfish; D011721:Pyrenes / Q000378:metabolism*
D004785:Environmental Pollutants; D011721:Pyrenes; C032668:1-nitropyrene