title: Detection of scleroderma with capillaroscopic abnormalities of nailfolds.
abstract: BACKGROUND
  Systemic scleroderma is a problem in Gifu Prefecture, Japan.
  
  
  METHODS
  Three hundred and thirty-two men and 731 women over 30 years of age, who attended the residents' health examination in K town of Gifu Prefecture (population 4835 persons over 30 years of age) had a dermatologic examination. Antinuclear antibody was determined in 85 persons (14 men, 71 women; age 30 to 72 years) who had Raynaud's phenomenon or various clinical features related to systemic scleroderma. Of these 85 persons, 19 agreed to a capillaroscopic examination and of these, 16 showed some capillaroscopic abnormalities. Biopsy specimens of three women among these 16 individuals with capillaroscopic abnormalities were examined also histopathologically.
  
  
  RESULTS
  All samples taken from the forearm skins showed thick and packed bundles of collagen with hyalinization and thickened small blood vessels in the dermis, similar to histopathologic features of systemic scleroderma, although all these women had only a sausage-like swelling of the fingers and a shortened frenulum of the tongue. These results suggest that the prevalence of systemic scleroderma can be estimated to affect more than 0.38% of the population in this town.
  
  
  CONCLUSIONS
  Manual skills and vibration exposure may be associated with systemic scleroderma.
authors.affiliation: Department of Dermatology, Gifu University, School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Maeda
authors.forename: Y
authors.initials: Y
authors.lastname: Ichiki
authors.forename: Y
authors.initials: Y
authors.lastname: Shikano
authors.forename: S
authors.initials: S
authors.lastname: Mori
authors.forename: Y
authors.initials: Y
authors.lastname: Kitajima
mesh_terms: D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D002196:Capillaries / Q000473:pathology*; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009262:Nails / Q000098:blood supply*; D012595:Scleroderma, Systemic / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D012867:Skin / Q000098:blood supply / Q000473:pathology
chemical_list: D000974:Antibodies, Antinuclear