[Saturated heterocyclic compounds. 216 (1). Synthesis, structure and ring opening of trans-perhydro-1,4-benzoxazepin-3-one derivatives].
trans-Perhydro-1,4-benzoxazepin-3-ones 2a-e were synthesized and transformed to condensed-skeleton perhydro-trans-1,4-benzoxazepines 3a,b, the thiones 4a,b, the urea derivatives 5a,b, and N-acylated compounds 6a-e. Compounds 6b,d were ring-opened by hydrochloride acid in ethanol to yield trans-2 (1-carbethoxyethoxy)-1-(acylaminomethyl)-cyclohexane derivatives 7b,d. The 1H- and 13C-nmr investigation and X-ray analysis of 5b and 6c,d proved that the expected N-acylated derivatives were formed and that both rings of the annolated compounds have a chair conformation.
Simon
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L
Szent-Gyorgyi Albert Orvostudomanyi Egyeten, Gyogyszerkemiai Intezet, Szeged.
Fülöp
F
F
Bernáth
G
G
Argay
G
G
Kálmán
A
A
Sohár
P
P
D000107:Acetylation; D007202:Indicators and Reagents; D008958:Models, Molecular; D015394:Molecular Structure; D010077:Oxazepines / Q000138:chemical synthesis / Q000737:chemistry*; D013329:Structure-Activity Relationship
D007202:Indicators and Reagents; D010077:Oxazepines
Telített heterociklusok, 216 [1]. Transz-Perhidro-1, 4-benzoxazepin-3-on származékok szintézise és gyürüfelnyílása.