[Prediction of the effects of energy-stabilizing drugs in diabetes mellitus].
The authors describe a method for the prediction of the therapeutic effect of energy-stabilizing drugs, that helps rapidly select the optimal individual therapeutic policy. The method is based on measurement of the red cell ATP concentration in the course of in vitro incubation of cells in polyionic medium with the drug, and may be used in various diseases associated with energy metabolism disorders on the cellular level. The authors have used this method for the selection of a thiamine drug to be included in therapy of a diabetic in the period of the disease compensation.
Chobitko
V G
VG
Zakharova
N B
NB
D000225:Adenine / Q000008:administration & dosage / Q000627:therapeutic use*; D000255:Adenosine Triphosphate / Q000097:blood; D002478:Cells, Cultured; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism*; D004359:Drug Therapy, Combination; D004734:Energy Metabolism / Q000187:drug effects*; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008954:Models, Biological; D013831:Thiamine / Q000008:administration & dosage / Q000627:therapeutic use*; D013835:Thiamine Pyrophosphate / Q000008:administration & dosage / Q000627:therapeutic use*
D007328:Insulin; D000255:Adenosine Triphosphate; D000225:Adenine; D013835:Thiamine Pyrophosphate; D013831:Thiamine
Prognozirovanie deĭstviia énergostabiliziruiushchikh preparatov pri sakharnom diabete.