Normal function of the transcription factor NFAT1 in wasted mice. Chromosome localization of NFAT1 gene.
NFAT1 (NFATp), a cytosolic component of the nuclear factor of activated T cells (NFAT), is encoded by a single gene which was mapped to mouse chromosome 2 in the vicinity of the wasted (wst) locus. Although wasted mice display a severe immune disorder, they express normal levels of NFAT1 protein. The NFAT1 protein in wasted mice is properly regulated and possesses comparable DNA binding activity as that in their littermate controls. Therefore, the wasted phenotype is not due to a defect in the expression or early regulation of the NFAT1 protein.
Luo
C
C
Division of Cellular and Molecular Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Copeland
N G
NG
Jenkins
N A
NA
Edelhoff
S
S
Disteche
C
C
Hogan
P G
PG
Rao
A
A
D000818:Animals; D002460:Cell Line; D002874:Chromosome Mapping; D002890:Chromosomes, Human, Pair 20; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D008969:Molecular Sequence Data; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D019282:Wasting Syndrome / Q000235:genetics
D004268:DNA-Binding Proteins; D050778:NFATC Transcription Factors; C494006:NFATC2 protein, human; D009687:Nuclear Proteins; D014157:Transcription Factors