HLA class II genes associated with REM sleep behavior disorder.
Twenty-five white men with rapid eye movements (REM) sleep behavior disorder, but without narcolepsy, underwent HLA class II antigen typing: 84% (N=21) were DQwl (DQB1*05,06) positive (28% [N=7] were DR2 positive); DQB1*0501 (N=9) and DQB1*0602 (N=7) were the most common phenotypes. The 84% DQwl rate in men with REM sleep behavior disorder was significantly greater (p=0.015) than the 56% DQwl rate found in a local white comparison group (N=66), and was greater than the 39 to 66% DQwl rates published for 12 white groups (N=40-418/group). Thus, another disorder of REM sleep dysregulation (besides narcolepsy) appears to be strongly associated with specific HLA class II genes.
Schenck
C H
CH
Minnesota Regional Sleep Disorders Center, Hennepin County Medical Center, Minneapolis, MN 55415, USA.
Garcia-Rill
E
E
Segall
M
M
Noreen
H
H
Mahowald
M W
MW
D004576:Electromyography; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000032:analysis / Q000145:classification; D006683:HLA-DQ Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011930:Reaction Time; D012890:Sleep / Q000502:physiology; D012893:Sleep Wake Disorders / Q000235:genetics* / Q000276:immunology; D012895:Sleep, REM
D006680:HLA Antigens; D006683:HLA-DQ Antigens; C051568:HLA-DQ1 antigen