Neuroprotective effect of 4'-(4-methylphenyl)-2,2':6',2-terpyridine trihydrochloride, a novel inducer of nerve growth factor.
We have identified 4'-(4-methylphenyl)-2,2':6',2-terpyridine: trihydrochloride (SS701), which belongs to a family of a small unique neuroprotective agents. SS701 accelerated the production of nerve growth factor (NGF) in cultured astroglial cells, dose- and time-dependently. In in vivo studies, SS701, when administered 30 min after induced cerebral ischemia, neuroprotective effects on delayed neuronal death in Mongolian gerbils were evident. The neuroprotective effects of SS701 against ischemia-induced delayed neuronal death are attributed to stimulation of the production of NGF.
Yamamoto
K
K
1st Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Yoshikawa
R
R
Okuyama
S
S
Takahashi
Y
Y
Karasawa
Y
Y
Hino
N
N
Miyoshi
T
T
Araki
H
H
Hanabusa
K
K
Shirai
H
H
Tomisawa
K
K
D015082:2,2'-Dipyridyl / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001157:Arterial Occlusive Diseases / Q000473:pathology; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism; D016923:Cell Death; D002478:Cells, Cultured; D005260:Female; D005849:Gerbillinae; D051379:Mice; D008813:Mice, Inbred ICR; D009414:Nerve Growth Factors / Q000096:biosynthesis*; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology*; D011247:Pregnancy
D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; D015082:2,2'-Dipyridyl; C102502:4'-(4-methylphenyl)-2,2'-6',2''-terpyridine