title: EST! EST!! EST!!!
abstract: A recently published study has identified a set of candidate genes for human diseases based on findings from Drosophila. Each human expressed sequence tag (EST) in a large database was compared with all known Drosophila genes. After eliminating matches between genes of already known function, the remaining sequences were mapped in the human genome. In each region, the phenotypes of all known human diseases were compared with the phenotypes of known Drosophila mutations in order to identify candidate genes for the human diseases. Are the correspondences real or coincidental?
authors.affiliation: Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA. dhartl@oeb.harvard.edu
authors.forename: D L
authors.initials: DL
authors.lastname: Hartl
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D016208:Databases, Factual; D004330:Drosophila / Q000235:genetics; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D005821:Genetic Techniques; D015894:Genome, Human; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D009154:Mutation; D010641:Phenotype