Immunohistochemical investigation of human leukocyte antigen (HLA)-DR-positive astrocytes in adrenoleukodystrophy brain.
We investigated immunohistochemically the expression of human leukocyte antigen (HLA)-DR in postmortem brain tissue of two adult patients with adrenoleukodystrophy (ALD). In addition to microglia and macrophages, a significant number of star-like cells were stained positively for HLA-DR in demyelinating lesions of both patients. Such cells congregated in the peripheral zone of the lesions. A mirror image analysis as well as double immunostaining for HLA-DR and glial fibrillary acidic protein established that these cells were a subset of reactive astrocytes. Together with other reports demonstrating that astrocytes express HLA-DR only under very limited conditions, the results of this study suggest the involvement of immune and inflammatory responses in the pathological processes of ALD.
Katsuragi
T
T
Department of Psychiatry, Yokohama City University School of Medicine, Japan.
Iseki
E
E
Kosaka
K
K
Nishimura
T
T
Akiyama
H
H
Ikeda
K
K
Kato
M
M
D000326:Adrenoleukodystrophy / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D000328:Adult; D001253:Astrocytes / Q000276:immunology* / Q000378:metabolism; D001921:Brain / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D003711:Demyelinating Diseases / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged
D005904:Glial Fibrillary Acidic Protein; D006684:HLA-DR Antigens