Transcatheter arterial renal and adrenal embolization with iohexol-ethanol solutions. Animal experimental study and clinical application.
OBJECTIVE
The authors compared the embolic effect of radiolucent absolute ethanol (AE) with that of a radiopaque iohexol-ethanol (IES) solution for renal ablation in dogs and for the destruction of human aldosteronomas by the technique of transcatheter arterial embolization (TAE) to test whether IES can be an alternative to AE.


METHODS
The embolic agents were infused through a balloon catheter into the renal arteries of 17 dogs (9 infused with 0.3 mL/kg AE; 8 infused with IES). The immediate and parenchyma were compared between the two groups. Transcatheter arterial embolization with IES also was performed in three humans with unilateral aldosteronoma.


RESULTS
The IES was visualized faintly under fluoroscopy in all dogs. There were no significant differences in embolic effects between the AE and IES. Three patients with aldosteronoma were treated successfully by TAE with IES.


CONCLUSIONS
The IES can be used as a "visible ethanol" to improve the safety and ease of ethanol embolization.
Miyazono
N
N
Department of Radiology, Faculty of Medicine, Kagoshima University, Japan.
Ueno
K
K
Nakajo
M
M
Nishida
H
H
Inoue
H
H
Tsuchimochi
S
S
Hokotate
H
H
Yoshida
H
H
D000306:Adrenal Cortex Neoplasms / Q000098:blood supply / Q000175:diagnosis / Q000628:therapy*; D000328:Adult; D000818:Animals; D002404:Catheterization; D003287:Contrast Media / Q000008:administration & dosage*; D004285:Dogs; D004621:Embolization, Therapeutic / Q000379:methods*; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D005471:Fluoroscopy; D005500:Follow-Up Studies; D006801:Humans; D007261:Infusions, Intra-Arterial; D007472:Iohexol / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012077:Renal Artery; D012997:Solvents / Q000008:administration & dosage*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D003287:Contrast Media; D012997:Solvents; D000431:Ethanol; D007472:Iohexol