Analysis of L-myc and GSTM1 genotypes in Chinese non-small cell lung carcinoma patients.
The genotypes of L-myc and GSTM1 genes were studied in normal lung tissues of 98 non-small cell lung carcinoma (NSCLC) patients from Hong Kong using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) techniques. Results showed a statistical difference in L-myc genotypes between Chinese and African Americans (P = 0.02). A significant deficit in heterozygotes resulting in the departure from Hardy-Weinberg equilibrium in lung cancer female patients was detected (0.01 < P < 0.02). There were significant differences in survival times in patients having L-L and S-S genotypes, with shorter survival times in the patients with L-L genotypes (0.01 < P < 0.05). Data on age, size of tumor, histological types, and lymph node metastasis showed no significant association with L-myc genotype. The survival time in the GSTM1-negative (null gene) group was significantly different from the GSTM1 positive group between 16 and 24 months after operation (0.01 < P < 0.05). There was no significant difference in the distribution of GSTM1 genotypes between Chinese and Caucasian Americans.
Ge
H
H
Department of Biology, Hong Kong University of Science and Technology, Kowloon, Hong Kong.
Lam
W K
WK
Lee
J
J
Wong
M P
MP
Yew
W W
WW
Lung
M L
ML
D014408:Biomarkers, Tumor; D002289:Carcinoma, Non-Small-Cell Lung / Q000208:ethnology* / Q000235:genetics / Q000401:mortality; D002681:China / Q000453:epidemiology; D015342:DNA Probes / Q000737:chemistry; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D016259:Genes, myc / Q000235:genetics*; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D008175:Lung Neoplasms / Q000208:ethnology* / Q000235:genetics / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D012737:Sex Factors; D011795:Surveys and Questionnaires; D015996:Survival Rate
D014408:Biomarkers, Tumor; D015342:DNA Probes; D004273:DNA, Neoplasm; D007527:Isoenzymes; D005982:Glutathione Transferase