No evidence for functional GABA receptors in outer hair cells isolated from the apical half of the guinea-pig cochlea.
Outer hair cells, isolated from the apical cochlear turns, did not respond to GABA during whole-cell recording. A few cells did respond to acetylcholine. Thus we have no evidence to suggest that GABA acts as an efferent neurotransmitter in the cochlea.
Evans
M G
MG
Department of Physiology, School of Medical Sciences, Bristol, UK. coa33@cc.keele.ac.uk
Kiln
J
J
Pinch
D
D
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002469:Cell Separation; D048429:Cell Size / Q000187:drug effects / Q000502:physiology; D003051:Cochlea / Q000378:metabolism*; D018755:GABA Agonists / Q000494:pharmacology; D006168:Guinea Pigs; D018072:Hair Cells, Auditory, Outer / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008564:Membrane Potentials / Q000187:drug effects; D018408:Patch-Clamp Techniques; D018079:Receptors, GABA / Q000378:metabolism*
D018755:GABA Agonists; D018079:Receptors, GABA; D000109:Acetylcholine