Chromosome 18 translocation (18;21) (p11.1;p11.1) associated with psychosis in one family.
In the course of recruiting families with 2 schizophrenic siblings for genome screening and linkage studies, a family was found with mental retardation, schizophrenia, and/or other related psychotic illnesses in individuals who also had an unbalanced or balanced translocation between chromosomes 21-18 [t(18;21)(p11.1;p11.1)]. The pericentric region of chromosome 18 has already been noted as a possible location of a gene for bipolar psychosis. The family described here provides further evidence that this region should be examined for a candidate psychosis gene.
Smith
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AB
Department of Psychiatry, SUNY at Stony Brook, NY 11794, USA.
Peterson
P
P
Wieland
J
J
Moriarty
T
T
DeLisi
L E
LE
D000328:Adult; D002871:Chromosome Banding; D002887:Chromosomes, Human, Pair 18; D002891:Chromosomes, Human, Pair 21; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics; D007621:Karyotyping; D008297:Male; D010375:Pedigree; D011618:Psychotic Disorders / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics; D014178:Translocation, Genetic