title: Discovery of FK 506 analogues that are nontoxic to mouse pancreatic beta cells in vitro but show diabetogenic potential when administered to the rat.
authors.affiliation: Abbott Laboratories, Abbott Park, Illinois 60064-3500, USA.
authors.forename: K W
authors.initials: KW
authors.lastname: Mollison
authors.forename: J M
authors.initials: JM
authors.lastname: Andrews
authors.forename: T A
authors.initials: TA
authors.lastname: Fey
authors.forename: L N
authors.initials: LN
authors.lastname: Miller
authors.forename: R A
authors.initials: RA
authors.lastname: Krause
authors.forename: P T
authors.initials: PT
authors.lastname: Bretheim
authors.forename: J A
authors.initials: JA
authors.lastname: Brandt
authors.forename: R
authors.initials: R
authors.lastname: Wagner
authors.forename: B C
authors.initials: BC
authors.lastname: Lane
authors.forename: G C
authors.initials: GC
authors.lastname: Hsieh
authors.forename: J R
authors.initials: JR
authors.lastname: Luly
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002460:Cell Line; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects* / Q000502:physiology; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D051381:Rats; D011914:Rats, Inbred BN; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D016559:Tacrolimus / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000633:toxicity; D022021:Tacrolimus Binding Proteins
chemical_list: C102915:A 85917; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D006360:Heat-Shock Proteins; D007328:Insulin; D011993:Recombinant Fusion Proteins; C058028:immunomycin; D022021:Tacrolimus Binding Proteins; D016559:Tacrolimus