title: Inhibitory effect of caffeic acid phenethyl ester on human leukemia HL-60 cells.
abstract: Caffeic acid phenethyl ester (CAPE) was synthesized from caffeic acid and phenethyl alcohol (ratio 1:5) at room temperature with dicyclohexyl carbodiimide (DCC) as a condensing reagent. The yield was about 38%. CAPE was found to arrest the growth of human leukemia HL-60 cells. It also inhibits DNA, RNA and protein synthesis in HL-60 cells with IC50 of 1.0 microM, 5.0 microM and 1.5 microM, respectively.
authors.affiliation: Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers, State University of New Jersey, New Brunswick 08903, USA.
authors.forename: J H
authors.initials: JH
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: Shao
authors.forename: M T
authors.initials: MT
authors.lastname: Huang
authors.forename: C K
authors.initials: CK
authors.lastname: Chin
authors.forename: C T
authors.initials: CT
authors.lastname: Ho
mesh_terms: D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002109:Caffeic Acids / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D016588:Anticarcinogenic Agents; D002109:Caffeic Acids; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol