title: An early rise in urine N-telopeptide predicts the growth response of normal prepubertal short children to growth hormone therapy.
abstract: The effects of growth hormone (GH) therapy on biochemical markers of bone turnover were investigated in 11 short prepubertal children without GH deficiency by measuring serum osteocalcin, a marker for bone formation, and urinary concentrations of pyridinium cross-linked amino acids of collagen (PCL), and the peptide-bound pyridinoline residue N-telopeptide (NT), which are specific markers for bone resorption. GH treatment for three months increased bone turnover in this group of children: urinary PCL concentrations increased from 69 +/- 6.2 to 114 +/- 9.3 nmol/mmol Cr (p < 0.01), and urinary NT levels increased from 512 +/- 65 to 766 +/- 74 pmol BCE/mumol Cr (p = 0.058). Serum osteocalcin concentrations increased from 13.64 +/- 2.57 ng/ml to 26.45 +/- 1.39 ng/ml (p < 0.01). The increment in 12-hour urinary concentrations of PCL was highly correlated with the increment in 12-hour urinary NT levels (r = 0.92, p < 0.01). Stepwise multiple regression analysis revealed that the urinary concentrations of NT after 3 months of GH therapy were the best predictor of growth after 12 months of treatment (r = 0.78, F = 7.9, p = 0.037).
authors.affiliation: Pediatric Diagnostic and Therapeutic Center, Soroka Medical Center, Ben-Gurion University of the Negev Beer-Sheva, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Phillip
authors.forename: E
authors.initials: E
authors.lastname: Hershkovitz
authors.forename: Y
authors.initials: Y
authors.lastname: Limoni
authors.forename: E
authors.initials: E
authors.lastname: Leiberman
authors.forename: O
authors.initials: O
authors.lastname: Belotserkovsky
authors.forename: A
authors.initials: A
authors.lastname: Douvdevani
authors.forename: D
authors.initials: D
authors.lastname: Weber
mesh_terms: D001827:Body Height; D001846:Bone Development; D002648:Child; D003094:Collagen / Q000652:urine*; D024042:Collagen Type I; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D015675:Osteocalcin / Q000097:blood; D010455:Peptides / Q000652:urine*
chemical_list: D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D019382:Human Growth Hormone; D003094:Collagen