Effects of selective K(+)-channel agonists and antagonists on myoelectrical activity of a locus of the small bowel.
Effects of Ca(2+)-activated K+ and voltage-activated K(+)-channel agonists and antagonists on the myoelectrical and contractile activity of a locus of the small bowel are simulated numerically. The model assumes that the electrical activity of smooth muscle syncytium is defined by kinetics of a mixture of L- and T-type Ca(2+)-channels, Ca(2+)-activated K+ and voltage-activated K(+)-channels, and leak Cl(-)-channels, and that the smooth muscle syncytium of the locus is a null-dimensional contractile system. The results of modelling, both qualitatively and quantitatively, reproduce the effects of forskolin, lemakalim, phencyclidine, charybdotoxin and high concentration of external K+ ions, on gastrointestinal motility. This is confirmed by comparison with experimental observations conducted on the smooth muscle preparations of different species.
Miftakhov
R N
RN
Laboratory of Numerical Methods in Mathematical Physics, Kazan State University, Russia.
Abdusheva
G R
GR
D000818:Animals; D005769:Gastrointestinal Motility; D006801:Humans; D007421:Intestine, Small / Q000502:physiology*; D008962:Models, Theoretical; D026902:Potassium Channel Blockers; D015221:Potassium Channels / Q000819:agonists / Q000502:physiology
D026902:Potassium Channel Blockers; D015221:Potassium Channels