title: [The CO2 laser treatment of extensive skin changes to the vulva caused by the human papillomavirus (HPV) and refractory to other types of therapy].
abstract: The authors describe three cases of large vulvar lesions caused by HPV. One patient has condylomata covering entirely the labia majora and minora, the clitoris, the perineum and the perianal area. The lesions made the structures of the vulva hard to distinguish. She was treated with podophyllin, Solcoderm and diathermy without effect. After 2 applications of Laser vaporisation 40 days apart she was completely cured. The other patient had two big squamous papillomata 3.5 by 3.5 cm and 0.5 cm thick situated on both sides of commissura posterior. She was also treated unsuccessfully with Podophyllin, Solcoderm and surgical excision. She was completely cured by a single-stage CO2-laser treatment. The third patient had condylomata acuminata of the labia minora and majora, fossa navicularis, the perineum and the perianal area. No other treatment had been attempted before. After two sessions of laser vaporisation she was cured, too.
authors.forename: A
authors.initials: A
authors.lastname: Nachev
authors.forename: N
authors.initials: N
authors.lastname: Vasilev
authors.forename: S
authors.initials: S
authors.lastname: Ivanov
authors.forename: S
authors.initials: S
authors.lastname: Meziad
mesh_terms: D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D003218:Condylomata Acuminata / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D053685:Laser Therapy; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D017193:Skin Diseases, Viral / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D014412:Tumor Virus Infections / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D014844:Vulva / Q000601:surgery; D014845:Vulvar Diseases / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*
vernacular_title: Lechenie s CO2-lazer na obshirni kozhni izmeneniia po vulvata, prichineni ot choveshkiia papilomen virus (HPV) i nepoddali se na drug vid terapiia.