Islet cell and glutamic acid decarboxylase antibodies and heat-shock protein 65 responses in children with newly diagnosed insulin-dependent diabetes mellitus.
Islet cell antibodies (ICA) were detected in 66% and glutamic acid decarboxylase (GAD) antibodies in 64% of children (n = 47) with newly diagnosed insulin-dependent diabetes mellitus (IDDM). Fifteen percent of the patients had neither GAD nor ICA antibodies. Responses to mycobacterial heat-shock protein 65 (Hsp65) were detected in all patients. There was a significant correlation between anti-GAD antibodies and proliferation of peripheral blood mononuclear cells to Hsp65, and between ICA and antibodies to Hsp65.
Scheinin
T
T
Fourth Department of Surgery, Helsinki University Hospital, Finland.
Tran Minh
N N
NN
Tuomi
T
T
Miettinen
A
A
Kontiainen
S
S
D000293:Adolescent; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D001323:Autoantibodies / Q000276:immunology*; D001426:Bacterial Proteins; D018834:Chaperonin 60; D018833:Chaperonins / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000276:immunology*; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D007223:Infant; D007518:Isoantibodies / Q000096:biosynthesis*; D008213:Lymphocyte Activation
D000907:Antibodies, Bacterial; D001323:Autoantibodies; D001426:Bacterial Proteins; D018834:Chaperonin 60; D007518:Isoantibodies; C074119:heat-shock protein 65, Mycobacterium; C024211:islet cell antibody; D018833:Chaperonins; D005968:Glutamate Decarboxylase