title: [Analysis of spontaneous and ethylmethanesulfonate-induced visible mutations in the genetically unstable MS, w strain of Drosophila melanogaster].
abstract: We analyzed genetic effects of ethylmethanesulfonate (EMS) on mature sperm of males of the Drosophila melanogaster MS, w strain. The frequency of induced mutations was estimated in the X chromosome, in five loci of chromosome 2 (b, j, pr, cn, and vg), and in eight loci of chromosome 3 (ru, h, th, st, cu, sr, es, and ca). Mutability was significantly increased in the genetically unstable MS, w strain in comparison with the reference laboratory ss, w strain. In MS, w, genetic instability was characteristic of more than 50% EMS-induced mutations. Analysis of the mutation spectrum revealed a specific distribution along the chromosomes. In MS, w, exhibition of spontaneous and induced instability was shown to be similar. This could imply a common mechanism of control of mutability involving transpositions of mobile genetic elements.
authors.forename: N I
authors.initials: NI
authors.lastname: Romanova
authors.forename: M M
authors.initials: MM
authors.lastname: Aslanian
authors.forename: A I
authors.initials: AI
authors.lastname: Kim
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D004331:Drosophila melanogaster / Q000235:genetics*; D005020:Ethyl Methanesulfonate / Q000633:toxicity*; D017344:Genes, Insect; D008297:Male; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation; D013045:Species Specificity; D013094:Spermatozoa / Q000187:drug effects*; D014960:X Chromosome
chemical_list: D009153:Mutagens; D005020:Ethyl Methanesulfonate
vernacular_title: Analiz spontannykh i indutsirovannykh étilmetansul'fonatom vidimykh mutatsiĭ v geneticheski nestabil'noĭ linii MS, w Drosophila melanogaster.