title: Localized scleroderma in breast cancer patients treated with supervoltage external beam radiation: radiation port scleroderma.
abstract: BACKGROUND
  An association between systemic scleroderma, radiation, and breast cancer has been recognized. However, localized scleroderma in the radiation port of breast cancer patients has been rarely described.
  
  
  OBJECTIVE
  Our purpose was to describe the concurrence of localized scleroderma, supervoltage radiation, and breast carcinoma.
  
  
  METHODS
  Patients were prospectively evaluated in a tertiary care cancer center, and the literature was reviewed.
  
  
  RESULTS
  We describe six patients with breast cancer in whom localized scleroderma developed within their radiation port.
  
  
  CONCLUSIONS
  Radiation port localized scleroderma can be a sequela of supervoltage radiation therapy in patients with breast cancer. Recognition is important because localized scleroderma can clinically mimic recurrent breast carcinoma.
authors.affiliation: Department of Dermatology, University of Texas, Medical Branch, Galveston 77555, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Davis
authors.forename: P R
authors.initials: PR
authors.lastname: Cohen
authors.forename: M D
authors.initials: MD
authors.lastname: McNeese
authors.forename: M
authors.initials: M
authors.lastname: Duvic
mesh_terms: D001943:Breast Neoplasms / Q000532:radiotherapy*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D011855:Radiodermatitis / Q000473:pathology; D011882:Radiotherapy, High-Energy / Q000009:adverse effects*; D012594:Scleroderma, Localized / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000556:secondary