[Regulation of uterine cellular proliferation with estrogens and growth factors].
In this paper the role of estrogen and growth factors in the uterine cellular proliferation is analyzed. The evidences indicate that the estradiol-stimulate cell division is associated with the induction of expression of a variety of growth factors from the all major uterine cell types (epithelia, stroma and myometrium). These growth factors amplify the estrogen proliferation signal in autocrine and/or paracrin fashion. The best-studied growth factors in the uterine response to estradiol are epidermal growth factor (EGF) and insulin-like growth factor (IGF-1). Uterine cell proliferation is a complex process that involves interactions of several growth factors, ovarian steroids hormones action and cell to cell signaling.
Alvarez-Rodríguez
C
C
Laboratorio de Biología del Desarrollo, Unidad de Morfología y Función, ENEP Iztacala, UNAM, Tlalnepantla, Edo. de Mexico.
Baiza-Guzmán
L A
LA
D000328:Adult; D002455:Cell Division / Q000187:drug effects*; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D014599:Uterus / Q000166:cytology*
D004958:Estradiol; D004815:Epidermal Growth Factor; D007334:Insulin-Like Growth Factor I
Regulación de la proliferación celular uterina por estrógenos y factores de crecimiento.