title: Experimental measure of the tensile strength of biological sealant-collagen association after hepatectomy in dogs.
abstract: Fibrin sealants are commonly used in liver surgery. The aim of this study was to test the adhesive properties of a biological sealant-collagen bonding, using an experimental model. After hepatectomy in dogs, we measured the rupture stress point of a fibrin clot on the liver cross-section. The tensile strength was 0.28 N, 5 times higher than the force of arterial pressure in a 2-mm-diameter vessel. These results indicate that the adhesion of fibrin sealants is effective to prevent hemorrhage from the liver cross-section after hepatectomy.
authors.affiliation: Groupe de Biochimie et Physiopathologie Digestive et Nutritionnelle, Centre Hospitalier Universitaire, Rouen, France.
authors.forename: M
authors.initials: M
authors.lastname: Scotté
authors.forename: F
authors.initials: F
authors.lastname: Dujardin
authors.forename: A
authors.initials: A
authors.lastname: Amelot
authors.forename: P
authors.initials: P
authors.lastname: Azema
authors.forename: I
authors.initials: I
authors.lastname: Leblanc
authors.forename: P
authors.initials: P
authors.lastname: Bouvier
authors.forename: F
authors.initials: F
authors.lastname: Michot
authors.forename: P
authors.initials: P
authors.lastname: Ténière
mesh_terms: D000818:Animals; D003094:Collagen; D004285:Dogs; D015718:Fibrin Tissue Adhesive; D006498:Hepatectomy; D008297:Male; D013718:Tensile Strength
chemical_list: D015718:Fibrin Tissue Adhesive; D003094:Collagen