[The role of thyroid hormones in the regulation of phosphatidic acid, phosphatidylinositol, and polyphosphoinositide synthesis in liver cells].
The effect of thyroxine on total phospholipid, phosphatidic acid, phosphatidylinositol, phosphatidylinositol-4-phosphate and phosphatidylinositol-4,5-bisphosphate synthesis in albino rat hepatocytes, has been studied. It has been found that the hormone enhances the [14C]palmitic acid incorporation into lipids. It has been shown also that phorbol-12-myristate-13-acetate mimicks the effect of thyroxine on lipid synthesis, while exogenous sphingosine abolishes it. Sphingosine causes a significant inhibition of phosphoinositide synthesis in intact liver cells.
Krasil'nikova
O A
OA
Babenko
N A
NA
D000818:Animals; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D019308:Palmitic Acid / Q000378:metabolism; D010712:Phosphatidic Acids / Q000096:biosynthesis*; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000096:biosynthesis*; D018129:Phosphatidylinositol Phosphates / Q000096:biosynthesis*; D010716:Phosphatidylinositols / Q000096:biosynthesis*; D011493:Protein Kinase C / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013110:Sphingosine / Q000494:pharmacology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D013974:Thyroxine / Q000494:pharmacology*
D010712:Phosphatidic Acids; D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; D019308:Palmitic Acid; D011493:Protein Kinase C; D013110:Sphingosine; D013755:Tetradecanoylphorbol Acetate; D013974:Thyroxine
Rol' tireoidnykh gormonov v reguliatsii sinteza fosfatidnoĭ kisloty, fosfatidilinozita i polifosfoinozitidov v kletkakh pecheni.