Route of administration determines the efficacy of rapamycin but not the mechanisms of tolerance induced by it in rats.
Lin
Y
Y
Laboratory for Experimental Transplantation, University of Leuven, Belgium.
Rutgeerts
O
O
Waer
M
M
D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology; D004359:Drug Therapy, Combination; D006085:Graft Survival / Q000187:drug effects; D016027:Heart Transplantation / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000494:pharmacology; D007262:Infusions, Intravenous; D007274:Injections, Intraperitoneal; D011090:Polyenes / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012086:Reoperation; D020123:Sirolimus; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D011090:Polyenes; D016572:Cyclosporine; D020123:Sirolimus