The activity of dihydropyrimidine dehydrogenase from rat liver was not affected by any of five 5-hydroxytryptamine antagonists.
We estimate the influence of five 5-hydroxytryptamine receptor (5-HT3) antagonists on the activity of dihydropyrimidine dehydrogenase (DPDase), the rate-limiting enzyme in 5-fluorouracil (5FU) metabolism. The activity of DPDase from the rat liver was compared in the cytosol mixture of 5FU incubated with or without each of five 5-HT3 antagonists. DPDase activity was not altered in the presence of any 5-HT3 antagonist studied here. It may be inferred from these results that the any 5-HT3 receptor antagonist examined in this study has little or no effect on fluorouracil catabolism.
Tateishi
T
T
Department of Pharmacology, St. Marianna University School of Medicine, Kanagawa, Japan.
Nakura
H
H
Watanabe
M
M
Tanaka
M
M
Kumai
T
T
Kobayashi
S
S
D000818:Animals; D000932:Antiemetics / Q000494:pharmacology*; D000964:Antimetabolites, Antineoplastic / Q000493:pharmacokinetics*; D001711:Biotransformation; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology; D003600:Cytosol / Q000201:enzymology; D042943:Dihydrouracil Dehydrogenase (NADP); D005472:Fluorouracil / Q000493:pharmacokinetics*; D017829:Granisetron / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D017294:Ondansetron / Q000494:pharmacology; D010078:Oxazines / Q000494:pharmacology; D010088:Oxidoreductases / Q000032:analysis*; D011807:Quinolizines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000187:drug effects*; D044406:Receptors, Serotonin, 5-HT3; D012702:Serotonin Antagonists / Q000494:pharmacology*; D000077526:Tropisetron
D000932:Antiemetics; D000964:Antimetabolites, Antineoplastic; D019086:Bridged Bicyclo Compounds, Heterocyclic; D042943:Dihydrouracil Dehydrogenase (NADP); D005472:Fluorouracil; D017829:Granisetron; D007211:Indoles; D017294:Ondansetron; D010078:Oxazines; D010088:Oxidoreductases; D011807:Quinolizines; D011985:Receptors, Serotonin; D044406:Receptors, Serotonin, 5-HT3; D012702:Serotonin Antagonists; D000077526:Tropisetron; C070671:azasetron; C060344:dolasetron