title: Transaxillary access to perform hepatic artery infusion (HAI) for secondary or primitive hepatic tumors.
abstract: There is a renewed interest in locoregional chemotherapy for hepatic tumors; trials in progress are experimenting with new therapeutic protocols with an approach combining different systems of infusion (HAI and systematic) or with the use of HAI as adjuvant or neoadjuvant of the surgical treatment or cryosurgical treatment of the hepatic metastases from colo-rectal cancer. However, HAI is practicable principally with the implantation of a catheter in the hepatic artery (port of Infusaid) by laparotomic access. This intervention limits wide-scale use of the infusion method, traditionally less toxic and more efficient in terms of results than systemic treatment. Limited experience of percutaneous access for HAI required more catheterisation with repeated puncturing of the artery and later necessity of surgery in cases of HAI with continuous spraying. Motivated by the first experience of certain authors from Chiba University, we have devised a system of catheterisation of the hepatic artery with transcutaneous access, with subcutaneous port that allows the use of HAI without recourse to the usual intervention. Access is made through the left axillary artery; the positioning of the catheter is in the hepatic artery with possible embolization of the collateral or abnormal hepatic artery that could hamper complete diffusion of the drug to the liver, or increase to toxicity of the method. The implantation is done in day-surgery. In the cases performed up to now there have been no complications regarding the method and the catheters function all perfectly thanks to the collaboration of ematologists to avoid possible thrombosis of the catheters.
authors.affiliation: Division of Oncological Surgery, University of Turin.
authors.forename: C
authors.initials: C
authors.lastname: Zanon
authors.forename: M
authors.initials: M
authors.lastname: Grosso
authors.forename: E
authors.initials: E
authors.lastname: Zanon
authors.forename: A
authors.initials: A
authors.lastname: Veltri
authors.forename: O
authors.initials: O
authors.lastname: Alabiso
authors.forename: M
authors.initials: M
authors.lastname: Bazzan
authors.forename: I
authors.initials: I
authors.lastname: Chiappino
authors.forename: A
authors.initials: A
authors.lastname: Mussa
mesh_terms: D000368:Aged; D001365:Axilla; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000379:methods*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008875:Middle Aged