title: Cost effectiveness of adjuvant intraportal chemotherapy in patients with colorectal cancer.
abstract: Recent studies have shown that the analysis of published survival curves allows cost-effectiveness evaluations in which two treatments are compared with each other in terms of cost per life-year saved. In patients with colorectal cancer, the administration of adjuvant intraportal chemotherapy (with mitomycin and fluorouracil) has been reported to improve long-term survival in comparison with patients who are not given this treatment. To assess the pharmacoceconomic profile of this adjuvant chemotherapy, we carried out an incremental cost-effectiveness analysis in which we used the Gompertz model to estimate lifetime patient years gained by patients given this chemotherapy in comparison with controls. Using the data of a published controlled long-term trial involving 252 patients treated with intraportal chemotherapy and 253 controls who were given no such therapy, we estimated that the adjuvant treatment improved life expectancy by 89 discounted patient years (or 218 undiscounted patient years) every 100 patients. Cost of chemotherapy was calculated as $107,720 for every 100 patients. On the basis of these data, the administration of adjuvant intraportal chemotherapy was found to imply an incremental cost of $1,210 per discounted life-year saved or $494 per undiscounted life-year saved. The cost-effectiveness ratio of adjuvant intraportal chemotherapy in patients with colorectal cancer seems to be particularly favorable in comparison with estimates of cost per life-year saved previously obtained in many other areas of pharmacological intervention. Even though systemic fluorouracil + levamisole is the form of adjuvant chemotherapy most widely used in these patients, intraportal chemotherapy has the best cost-effectiveness profile.
authors.affiliation: Drug Information Center, Azienda Ospedaliera Careggi, Florence, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Messori
authors.forename: L
authors.initials: L
authors.lastname: Bonistalli
authors.forename: M
authors.initials: M
authors.lastname: Costantini
authors.forename: G
authors.initials: G
authors.lastname: Trallori
authors.forename: E
authors.initials: E
authors.lastname: Tendi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000191:economics / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant / Q000191:economics; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000401:mortality; D003362:Cost-Benefit Analysis; D004334:Drug Administration Schedule; D017850:Economics, Pharmaceutical; D005472:Fluorouracil / Q000008:administration & dosage / Q000191:economics; D006493:Heparin / Q000008:administration & dosage / Q000191:economics; D006801:Humans; D007978:Levamisole / Q000008:administration & dosage / Q000191:economics; D008937:Mitomycins / Q000008:administration & dosage / Q000191:economics; D011168:Portal System; D015996:Survival Rate
chemical_list: D008937:Mitomycins; D007978:Levamisole; D006493:Heparin; D005472:Fluorouracil