title: [Gc-globulin in paracetamol poisoning].
abstract: Gc-globulin scavenges actin liberated from necrotic cells. We measured serum Gc-globulin and the degree of complexing with monomeric actin (complex ratio) in the initial phase of paracetamol (acetaminophen) intoxication and related this to the severity of liver necrosis and the clinical course. In eighteen patients with paracetamol intoxication serial measurements of serum Gc-globulin and complex ratio were determined from admission and every three hours thereafter. Eight patients developed hepatic encephalopathy (HE) and two of them died. On admission all patients had significantly reduced serum Gc-globulin levels compared to normal individuals, and patients with HE had significantly lower values than patients without HE. All patients with HE had at least three samples, where Gc-globulin was below 120 mg/l (35% of normal). Complex ratio on admission did not differ significantly in the patients with and those without HE. The peak complex ratio was higher in patients with HE than in patients without HE, and three of four patients with peak complex ratio above 75% had HE. In conclusion, Gc-globulin levels were found to be decreased in patients with paracetamol intoxication; this decrease correlated with the most severe sign of liver dysfunction, HE. Serum Gc-globulin below 120 mg/l and peak complex ratios above 75% may be critical values.
authors.affiliation: Medicinsk afdeling A., Rigshospitalet, København.
authors.forename: F V
authors.initials: FV
authors.lastname: Schiødt
authors.forename: S
authors.initials: S
authors.lastname: Bondesen
authors.forename: N
authors.initials: N
authors.lastname: Tygstrup
mesh_terms: D000082:Acetaminophen / Q000506:poisoning*; D000328:Adult; D000700:Analgesics / Q000506:poisoning*; D005260:Female; D005916:Globulins / Q000032:analysis*; D006501:Hepatic Encephalopathy / Q000097:blood / Q000139:chemically induced; D006801:Humans; D008297:Male; D011041:Poisoning / Q000097:blood*; D011379:Prognosis; D014809:Vitamin D-Binding Protein / Q000032:analysis*
chemical_list: D000700:Analgesics; D005916:Globulins; D014809:Vitamin D-Binding Protein; D000082:Acetaminophen
vernacular_title: Gc-globulin ved paracetamolforgiftning.