[Induction of prostatic buds in the urogenital sinus in Tfm mouse embyos without androgen receptors].
We have studied the prostatic bud induction in the urogenital sinus of androgen-receptor deficient mice, and found that epidermal growth factor (EGF), keratinocyte growth factor (KGF) as well as transforming growth factor-alpha (TGF-alpha) can provoke prostatic bud formation in the androgen-receptor deficient sinus cultured in the medium deprived of androgens.
Mizuno
T
T
Département de Biologie, Faculté des Sciences pharmaceutiques, Teikyo Université, Kanagawa-ken, Japan.
Saito
M
M
D000818:Animals; D004627:Embryonic Induction; D004815:Epidermal Growth Factor / Q000494:pharmacology; D006133:Growth Substances / Q000494:pharmacology; D015603:Keratinocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D009924:Organ Culture Techniques; D011467:Prostate / Q000187:drug effects / Q000196:embryology*; D011994:Recombinant Proteins / Q000494:pharmacology; D016211:Transforming Growth Factor alpha / Q000494:pharmacology; D014566:Urogenital System / Q000187:drug effects / Q000196:embryology*
D006133:Growth Substances; D011994:Recombinant Proteins; D016211:Transforming Growth Factor alpha; D004815:Epidermal Growth Factor
Induction de bourgeons prostatiques dans le sinus urogénital d'embryons de Souris Tfm dépourvu de récepteurs d'androgènes.