Small GTPase-regulated phospholipase D in granulocytes.
This review examines the functional role of phospholipase D in the neutrophil. Phospholipase D is emerging as an important component in the signal transduction pathways leading to granulocyte activation. Through the second messenger it produces, phosphatidic acid, phospholipase D plays an active role in the regulation of granulocyte NADPH oxidase activation and granular secretion. Many factors from both the cytosol and the membrane are necessary for maximal phospholipase D activation. This paper will focus on the regulation of phospholipase D by low molecular weight GTP-binding proteins, tyrosine kinases, and protein kinase C.
Houle
M G
MG
Centre de Recherche en Rhumatologie et Immunologie, Faculty of Medicine, Université Laval, Ste-Foy, Québec, Canada.
Bourgoin
S
S
D000818:Animals; D004789:Enzyme Activation; D020558:GTP Phosphohydrolases / Q000097:blood*; D019204:GTP-Binding Proteins / Q000097:blood; D006801:Humans; D009504:Neutrophils / Q000201:enzymology*; D010739:Phospholipase D / Q000097:blood*; D011493:Protein Kinase C / Q000097:blood; D011505:Protein-Tyrosine Kinases / Q000097:blood; D015398:Signal Transduction; D020742:rhoA GTP-Binding Protein
D011505:Protein-Tyrosine Kinases; D011493:Protein Kinase C; D010739:Phospholipase D; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins; D020742:rhoA GTP-Binding Protein