[Immunopathology of malaria: emergence of a new T-lymphocyte reactivity].
Recent knowledge on certain populations of non-conventional T-lymphocytes has suggested that gamma delta T cells might play an important role in the orientation of the immune response. In human and mouse malaria, massive activation of the gamma delta T cell population is observed. This activation can lead to the production of high levels of pro-inflammatory cytokines relevant for malaria pathology induction. Studies investigating the role of gamma delta T cells have been conducted in different mice model where alpha beta T cells have been eliminated. In these studies, gamma delta T cells have been shown to be protective against the pre-erythrocytic stage of malaria infection but their role remains unclear concerning the blood infection. The recent discovery of the set of ligands leading to simulation of Human gamma delta T cell subsets expressing the V gamma 9V delta 2 chains of the T cell receptor may give new insights about their mode of activation and their potential role in the induction of malaria pathology.
Behr
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Unité d'Immunologie moléculaire des parasites, URA 1960, Institut Pasteur, Paris.
D000818:Animals; D016207:Cytokines / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000276:immunology*; D008288:Malaria / Q000276:immunology*; D051379:Mice; D010961:Plasmodium / Q000276:immunology / Q000472:pathogenicity; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D016207:Cytokines
Immunopathologie du paludisme: émergence d'une nouvelle réactivité lymphocytaire T.