Long-term neuropsychological risks in pediatric bone marrow transplant: what do we know?
While research has documented neuropsychological sequelae following cranial radiation and chemotherapy for childhood cancer, little is known about the effects of the BMT process on the neuropsychological functioning of children. Results from ongoing studies at The University of Iowa indicate that at pre-BMT evaluations, children who have had prior CRT already show signs of declining IQ scores and below average academic achievement. By 4 years post-BMT, there is evidence of declining IQ, achievement, memory, and fine motor skills. Risk factors appear to be younger age at diagnosis and CRT prior to BMT but additional research is needed.
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Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City 52242, USA.
D000367:Age Factors; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000523:psychology; D002648:Child; D016371:Cranial Irradiation / Q000009:adverse effects*; D006130:Growth Disorders / Q000209:etiology* / Q000517:prevention & control; D006402:Hematologic Diseases / Q000523:psychology / Q000628:therapy; D006801:Humans; D007360:Intelligence; D007859:Learning Disabilities / Q000209:etiology / Q000517:prevention & control; D007938:Leukemia / Q000523:psychology / Q000628:therapy; D008569:Memory Disorders / Q000209:etiology / Q000517:prevention & control; D001523:Mental Disorders / Q000209:etiology* / Q000517:prevention & control; D009422:Nervous System Diseases / Q000209:etiology* / Q000517:prevention & control; D009483:Neuropsychological Tests; D011597:Psychomotor Performance; D012306:Risk; D019172:Transplantation Conditioning / Q000009:adverse effects*