title: Lambert-Eaton myasthenic syndrome: clinical diagnosis, immune-mediated mechanisms, and update on therapies.
abstract: The Lambert-Eaton myasthenic syndrome (LEMS) is a rare condition in which weakness results from a presynaptic abnormality of acetylcholine release at the neuromuscular junction. It was first described as a paraneoplastic syndrome in patients with lung cancer but we now know about half of the patients with LEMS do not have cancer. The diagnosis is made on the basis of the clinical findings and characteristic electromyographic patterns. Recent evidence indicates that LEMS results from an autoimmune attack directed against the voltage-gated calcium channels on the presynaptic motor nerve terminal. In patients with LEMS who have cancer, effective treatment of the underlying tumor frequently produces marked improvement of weakness as well. Otherwise, treatment involves the use of agents that improve neuromuscular transmission by increasing the release of neurotransmitter, and immunosuppression.
authors.affiliation: Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: D B
authors.initials: DB
authors.lastname: Sanders
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000319:Adrenergic beta-Antagonists; D000368:Aged; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000628:therapy; D015220:Calcium Channels / Q000276:immunology*; D002648:Child; D000075202:Contraindications; D004576:Electromyography; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015624:Lambert-Eaton Myasthenic Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000209:etiology; D009369:Neoplasms / Q000150:complications / Q000276:immunology; D009431:Neural Conduction / Q000187:drug effects; D009466:Neuromuscular Blocking Agents; D009469:Neuromuscular Junction / Q000503:physiopathology; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000209:etiology / Q000276:immunology / Q000628:therapy; D017729:Presynaptic Terminals / Q000276:immunology*
chemical_list: D000319:Adrenergic beta-Antagonists; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D015220:Calcium Channels; D007166:Immunosuppressive Agents; D009466:Neuromuscular Blocking Agents; C053157:omega-conotoxin receptor; D000109:Acetylcholine