[Metachronous cancer of the gastro-intestinal tract with signs of endocrine-cell differentiation].
A case of metachronous cancer of gastrointestinal tract is reported. Three poorly differentiated malignant epithelial tumours developed in a 27-year-old patient within three years. They located in the stomach, small and large intestine. Light-microscopically, the tumours were formed mainly of non-differentiated rounded cells with occasional signet ring cells. At electron microscopic examination the presence of mucin granules was confirmed. Moreover, a variable amount of electron-dense endocrine-like granules was found in tumour cells. According to some publications, endocrine differentiation of gastrointestinal cancers is considered to be a poor prognostic feature, hence electron microscopy or special staining when possible can be important in the evaluation of prognosis.
Turbin
D A
DA
Perevoshchikov
A G
AG
Chistiakova
O V
OV
Konstantinova
L N
LN
Kirichenko
O P
OP
Fleĭshman
E V
EV
D001078:APUD Cells / Q000473:pathology*; D000328:Adult; D002277:Carcinoma / Q000235:genetics / Q000473:pathology*; D002454:Cell Differentiation / Q000502:physiology; D005770:Gastrointestinal Neoplasms / Q000235:genetics / Q000473:pathology*; D006801:Humans; D007621:Karyotyping; D008297:Male; D008854:Microscopy, Electron; D009077:Mucins / Q000648:ultrastructure; D016609:Neoplasms, Second Primary / Q000235:genetics / Q000473:pathology*; D011379:Prognosis
D009077:Mucins
Metakhronnyĭ rak zheludochno-kishechnogo trakta s priznakami éndokrinnokletochnoĭ differentsirovki.