[The development of Ascaris suum eggs in the presence of moxidectin].
The development of Ascaris suum eggs maintained in the culture containing moxidectin (Cydectin, Cyanamid) in concentration 1, 5, 25, and 50 micrograms/ml was studied. The abnormalities and slowing down of the rate of eggs development, depending on the drug concentration, were observed. Exposure of eggs to moxidectin in concentration 1 and 5 microgram/ml resulted in one- or two-week delay of development. In the higher concentration of moxidectin (25 micrograms/ml) only 18% of eggs became invasive. In the presence of 50 micrograms/ml of the drug only few eggs developed to invasive stage after 7 weeks. The development of embryons was stopped more often in the blastula or gastrula stage. The drug's solvent in the highest concentration restricted the development of Ascaris eggs by about 10%. Unembryonated eggs of the worm appeared to be unaffected by 50 micrograms/ml of moxidectin treatment lasting 1-4 days, but for slowing down a little the development rate. The same concentration of the drug in the culture during the first four days of development resulted in 20% reduction of invasive stage in comparison to the control.
Zółtowska
K
K
Katedra Biologii Ogólnej WSP, Olsztyn.
Kurowicka
B
B
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D000900:Anti-Bacterial Agents; D017165:Ascaris suum / Q000187:drug effects* / Q000502:physiology; D046508:Culture Techniques; D018942:Macrolides / Q000494:pharmacology; D010063:Ovum / Q000187:drug effects*
D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D018942:Macrolides; C027837:moxidectin
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