Effect of nipradilol, a beta-adrenergic blocker with vasodilating activity, on oxotremorine-induced tremor in mice.
The effect of nipradilol, a nonselective beta-adrenergic receptor blocker with nitroglycerin-like vasodilating activity, on oxotremorine-induced tremor was studied in mice. General tremor in mice was elicited by 0.5 mg/kg oxotremorine. The tremor was quantified using a capacitance transducer, then analyzed by a signal processor. The strength of the tremor was expressed in "points". The point values of the tremor (mean +/- SE) in control mice for 5 mg/kg (+/-)-propranolol, 2.5 mg/kg arotinolol, 0.5 mg/kg nipradilol, 1.0 mg/kg nipradilol and 2.5 mg/kg nipradilol were 87 +/- 16, 42 +/- 6, 38 +/- 6, 99 +/- 28, 28 +/- 6 and 31 +/- 7, respectively. The strength of the tremor was reduced by all beta-blockers. Although 1.0 mg/kg nipradilol significantly reduced the tremor, further inhibition of the tremor was not obtained with dosages up to 2.5 mg/kg of the drug. In conclusion, nipradilol was effective for suppressing oxotremorine-induced tremor, as were other beta-blockers.
Iwata
S
S
Department of Pharmacology, Faculty of Medicine, University of Kagoshima, Japan.
Nomoto
M
M
Fukuda
T
T
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D008297:Male; D051379:Mice; D010095:Oxotremorine; D011412:Propanolamines / Q000494:pharmacology*; D014202:Tremor / Q000139:chemically induced* / Q000503:physiopathology / Q000517:prevention & control; D014665:Vasodilator Agents / Q000494:pharmacology*
D000318:Adrenergic beta-Agonists; D011412:Propanolamines; D014665:Vasodilator Agents; D010095:Oxotremorine; C036089:nipradilol