[Integrins and cadherins: two superfamilies of adhesive receptors].
In this paper, two adhesive receptors are presented. The first one, the integrin alpha IIb beta 3 is implied in platelet aggregation following vascular damage. The second one is the VE-cadherin, which is specifically expressed on endothelial cells and participates in the maintenance of endothelium integrity. Their structures and their physiological roles are discussed.
Gulino
D
D
INSERM 217, Département de Biologie Moléculaire et Structurale, Commissariat à l'Energie Atomique, Grenoble.
Sulpice
E
E
Alemany
M
M
D015703:Antigens, CD; D015820:Cadherins / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D010974:Platelet Aggregation; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000378:metabolism / Q000648:ultrastructure; D000099152:Cadherin 5
D015703:Antigens, CD; D015820:Cadherins; D016023:Integrins; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D000099152:Cadherin 5
Intégrines et cadhérines: deux superfamilles de récepteurs adhésifs.