title: Predicting visual acuity in children with colobomas involving the optic nerve.
abstract: BACKGROUND
  This study evaluates the relationship to visual acuity of four ophthalmoscopic features of colobomas involving the optic nerve. The goal was to identify those features that could predict potential visual acuity of children with these colobomas.
  
  
  METHODS
  Fundus photographs of 23 eyes with colobomas involving the optic nerve met the entry criteria and were evaluated by two masked observers. The following features were evaluated: coloboma size, optic nerve color, foveal development, and subfoveal retinal pigment epithelial changes. Simple linear regression was used to identify the feature that most closely correlated with visual acuity. Refractive status was assessed by cycloplegic refraction.
  
  
  RESULTS
  The only component that correlated with the development of good visual acuity was the degree of foveal involvement by the optic nerve coloboma (P = .002, R = 0.8). Significant refractive error and anisometropia were common in patients with colobomas involving the optic nerve.
  
  
  CONCLUSIONS
  Central visual acuity in children born with colobomas involving the optic nerve correlates with the development of normal foveal anatomy, regardless of the size of the coloboma, the color of the optic nerve, or the presence of subfoveal pigmentary changes. Because refractive error is common, these children should receive an accurate refraction and amblyopia treatment.
authors.affiliation: Department of Ophthalmology, University of Minnesota, Minneapolis, USA.
authors.forename: T W
authors.initials: TW
authors.lastname: Olsen
authors.forename: C G
authors.initials: CG
authors.lastname: Summers
authors.forename: W H
authors.initials: WH
authors.lastname: Knobloch
mesh_terms: D002675:Child, Preschool; D003103:Coloboma / Q000473:pathology / Q000503:physiopathology*; D005544:Forecasting; D005654:Fundus Oculi; D006801:Humans; D007223:Infant; D009887:Ophthalmoscopy; D009900:Optic Nerve / Q000002:abnormalities* / Q000473:pathology; D012029:Refraction, Ocular; D012189:Retrospective Studies; D014792:Visual Acuity