title: [Metachronous cancer of the gastro-intestinal tract with signs of endocrine-cell differentiation].
abstract: A case of metachronous cancer of gastrointestinal tract is reported. Three poorly differentiated malignant epithelial tumours developed in a 27-year-old patient within three years. They located in the stomach, small and large intestine. Light-microscopically, the tumours were formed mainly of non-differentiated rounded cells with occasional signet ring cells. At electron microscopic examination the presence of mucin granules was confirmed. Moreover, a variable amount of electron-dense endocrine-like granules was found in tumour cells. According to some publications, endocrine differentiation of gastrointestinal cancers is considered to be a poor prognostic feature, hence electron microscopy or special staining when possible can be important in the evaluation of prognosis.
authors.forename: D A
authors.initials: DA
authors.lastname: Turbin
authors.forename: A G
authors.initials: AG
authors.lastname: Perevoshchikov
authors.forename: O V
authors.initials: OV
authors.lastname: Chistiakova
authors.forename: L N
authors.initials: LN
authors.lastname: Konstantinova
authors.forename: O P
authors.initials: OP
authors.lastname: Kirichenko
authors.forename: E V
authors.initials: EV
authors.lastname: Fleĭshman
mesh_terms: D001078:APUD Cells / Q000473:pathology*; D000328:Adult; D002277:Carcinoma / Q000235:genetics / Q000473:pathology*; D002454:Cell Differentiation / Q000502:physiology; D005770:Gastrointestinal Neoplasms / Q000235:genetics / Q000473:pathology*; D006801:Humans; D007621:Karyotyping; D008297:Male; D008854:Microscopy, Electron; D009077:Mucins / Q000648:ultrastructure; D016609:Neoplasms, Second Primary / Q000235:genetics / Q000473:pathology*; D011379:Prognosis
chemical_list: D009077:Mucins
vernacular_title: Metakhronnyĭ rak zheludochno-kishechnogo trakta s priznakami éndokrinnokletochnoĭ differentsirovki.