title: [Undifferentiated small cell carcinoma (oat-cell type) of the colon. Prognostic and therapeutic implications].
abstract: OBJECTIVE
  This report reviews the clinical and pathologic features of four patients with small-cell anaplastic carcinoma (SCAC) of the colon and describes in detail their histological and immunohistochemical characteristics.
  
  
  METHODS
  Four patients with a SCAC of the colon diagnosed by conventional light microscopy, immunohistochemistry and ultrastructure were reviewed; clinical presentation, tumor location and spread, surgical procedure, adjuvant therapy and clinical outcome were recorded.
  
  
  RESULTS
  There were two women and two man, with an average age of 55 (range, 40-66) years. Two tumors were located in the sigmoid and two in right colon. Cases 1, 3 and 4 were removed at laparotomy by segmental resection along with lymph nodes. All cases had liver metastases. Pathologic study identified out-cell subtype in all cases and two histopathologic patterns: pure SCAC (cases 2 and 4) and mixed exocrine-SCC differentiation (cases 1 and 3). Three patients were treated with cyclophosphamide, cisplatin and etoposide. Two patients (cases 2 and 4) died of widely metastatic disease; cases 1 and 3 had partial remission lasting 9 and 3 months, respectively.
  
  
  CONCLUSIONS
  Due to extremely aggressive behavior of colon SCAC with early metastatic spread, CT scans of the chest-abdomen and radionuclide bone scan should be performed. In the presence of metastatic disease, multiagent chemotherapy with combined etoposide and cisplatin should be instituted.
authors.affiliation: Servicio de Cirugìa General A, Hospital Juan Canalej, La Coruna.
authors.forename: B
authors.initials: B
authors.lastname: Acea Nebril
authors.forename: M
authors.initials: M
authors.lastname: Bouso Montero
authors.forename: F
authors.initials: F
authors.lastname: Arnal Monreal
authors.forename: C
authors.initials: C
authors.lastname: Gómez Freijoso
authors.forename: F
authors.initials: F
authors.lastname: Sánchez González
authors.forename: D
authors.initials: D
authors.lastname: Freire Rodríguez
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D018288:Carcinoma, Small Cell / Q000473:pathology* / Q000628:therapy; D003110:Colonic Neoplasms / Q000473:pathology* / Q000628:therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor
vernacular_title: Carcinomas indiferenciados de células pequeñas (Tipo oat-cell) de colon. Implicaciones pronósticas y terapéuticas.