[The efficacy and safety of nafarelin in treating genital endometriosis].
A prospective study was carried out a State Institute Hospital "Maĭchin dom" aiming to estimate the efficacy of GnRH-agonist Nafarelin in treating patients with endometriosis. Nafarelin was used by 40 women with endometriosis. The drug was applied as a nasal spray according to a therapeutic scheme and regarding definite criteria. Every patient was followed while using the drug and the following sings were registered: occurrence of amenorrhea, clinical sings, side effects, the period of control lasting for a year after the end of the treatment. In 27 women a quick and long-lasting amenorrhoea was induced with standard doses of the drug, while other 13 needed higher dosage to achieve the same effect. Relief of complaints was registered on 35 women. Improved palpatory status was found in 23 patients. In 4 women the disappearance of endometriomas was confirmed by laparoscopy. The existing side-effects are dos to the appearing hypoestrogenemia. After treatment with Nafarelin, during the period of observation, 5 women got pregnant.
Nikolov
A
A
Karag'ozov
I
I
Novachkov
V
V
D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000139:chemically induced; D004341:Drug Evaluation; D004715:Endometriosis / Q000188:drug therapy*; D005260:Female; D006728:Hormones / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D017274:Nafarelin / Q000008:administration & dosage* / Q000009:adverse effects; D011446:Prospective Studies; D013997:Time Factors
D006728:Hormones; D017274:Nafarelin
Efikasnost i sigurnost na nafarelin za lechenie na genitalnata endometrioza.