title: Developmental toxicity study of 60 Hz (power frequency) magnetic fields in rats.
abstract: Considerable public concern has developed regarding possible adverse reproductive outcomes resulting from exposure to power frequency magnetic fields (MF). To identify possible effects of MF exposure on fetal development, timed-pregnant female Sprague-Dawley rats (55/ group) received continuous exposure to linearly polarized, transient-free 60 Hz MF at field strengths of 0 Gauss (G; sham control), 0.02 G, 2 G, or 10 G, or intermittent (1 hr on/1 hr off) exposure to 10 G fields. Dams received MF or sham exposures for 18.5 hr/day on gestation days 6 through 19. A positive control group of 15 dams received daily oral doses of 85 mg ethylenethiourea (ETU)/kg body weight on gestation days 11, 12, and 13; positive control dams received no MF exposure. Ambient and experimentally generated MF were monitored continuously throughout the study. Experimentally generated MF were within 2% of the target field strengths at all times, and ambient MF to which sham controls were exposed did not exceed 0.7 mG at any point in the study. No evidence of maternal toxicity was identified in any MF-exposed dam; mean maternal body weight and organ weights in groups exposed to MF did not differ from those in sham controls. Comparisons of fetal viability and body weight demonstrated no biologically significant differences between MF-exposed groups and sham controls. Similarly, a battery of gross external, visceral, skeletal, and cephalic examinations demonstrated no significant differences in the incidence of fetal malformations or anomalies in MF-exposed groups vs. sham controls. By contrast, 100% of the fetuses in the positive control group treated with ETU demonstrated malformations and reduced body weight. Exposure of pregnant Sprague-Dawley rats to 60 Hz at field strengths up to 10 G during gestation days 6-19 did not produce biologically significant effects in either dams or fetuses. These results do not support the hypothesis that exposure to pure, linearly polarized 60 Hz MF is a significant risk factor for the developing fetus.
authors.affiliation: Life Sciences Department, IIT Research Institute, Chicago, Illinois 60616, USA.
authors.forename: B M
authors.initials: BM
authors.lastname: Ryan
authors.forename: E
authors.initials: E
authors.lastname: Mallett
authors.forename: T R
authors.initials: TR
authors.lastname: Johnson
authors.forename: J R
authors.initials: JR
authors.lastname: Gauger
authors.forename: D L
authors.initials: DL
authors.lastname: McCormick
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000016:Abnormalities, Radiation-Induced / Q000209:etiology; D000818:Animals; D001835:Body Weight / Q000528:radiation effects; D001842:Bone and Bones / Q000002:abnormalities; D001921:Brain / Q000002:abnormalities; D004574:Electromagnetic Fields / Q000009:adverse effects*; D005314:Embryonic and Fetal Development / Q000187:drug effects / Q000528:radiation effects*; D005031:Ethylenethiourea / Q000633:toxicity; D005260:Female; D008297:Male; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012098:Reproduction / Q000528:radiation effects
chemical_list: D005031:Ethylenethiourea