title: Strategies for extraction of quantitative data from volumetric dynamic cardiac positron emission tomography data.
abstract: The ability of positron emission tomography (PET) to serve as a useful myocardial perfusion indicator is well established. We describe a methodology for obtaining reliable quantitative kinetic parameters from dynamic cardiac PET data. Reconstructed images of the myocardium are subdivided into three-dimensional volumes of interest which are used to obtain quantitative measures of myocardial perfusion over physiologically meaningful anatomical regions. The quantitation technique rigorously models the uncertainty of estimated parameters while compensating for effects such as patient motion and partial volumes to arrive at model parameters with well-established confidence intervals.
authors.affiliation: Lawrence Berkeley National Laboratory, University of California, 94720, USA.
authors.forename: R H
authors.initials: RH
authors.lastname: Huesman
authors.forename: G J
authors.initials: GJ
authors.lastname: Klein
authors.forename: B W
authors.initials: BW
authors.lastname: Reutter
authors.forename: P G
authors.initials: PG
authors.lastname: Coxson
authors.forename: E H
authors.initials: EH
authors.lastname: Botvinick
authors.forename: T F
authors.initials: TF
authors.lastname: Budinger
mesh_terms: D017023:Coronary Angiography / Q000379:methods; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D012414:Rubidium Radioisotopes; D014055:Tomography, Emission-Computed / Q000379:methods*
chemical_list: D012414:Rubidium Radioisotopes