[Neonatal detection of sickle cell disease in metropolitan France. Association française pour le dépistage et la prévention des handicaps de l'enfant (AFDPHE)].
Following the experimental program initiated in Martinique and Guadeloupe since 1983, a neonatal screening for sickle cell disease was extended to metropolitan France in 1990. It is presently applied to at risk newborns based on the parents ethnic origin, and associated with the screening for phenylketonuria, hypothyroidism and congenital adrenal hyperplaxia, in three regions. The laboratory method is reliable with a very limited number of false positive or false negative results. The cost effectiveness ratio appears very reasonable. All the children detected so far are correctly managed and have a normal development. This screening should be extended to the rest of France in the coming years.
Galactéros
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Service de biochimie, hôpital Henri-Mondor, Créteil, France.
D000755:Anemia, Sickle Cell / Q000517:prevention & control*; D005602:France; D006801:Humans; D007231:Infant, Newborn; D015997:Neonatal Screening / Q000191:economics / Q000379:methods*
Détection néonatale de la drépanocytose en France métropolitaine. Association française pour le dépistage et la prévention des handicaps de l'enfant (AFDPHE).