[Pharmacological correction of lipid peroxidation during hypoxia and possibility to enhance human resistance to high altitude by using preparations of the metabolic type of action].
In simulating acute hypoxic hypoxia with the participation of male volunteers, the authors investigated the antihypoxic and antioxidative activity of metabolic drugs (jakton, amtizole succinate, nootropil, probucol, and a mixture which consists of jakton, amtizole succinate, and probucol). The pharmaceuticals were shown to have heterodirectional effects on lipid peroxidative processes. Drugs having a pronounced antioxidative activity (such as probucol and the mixture) promotes oxygen utilization during hypoxia and posthypoxic reoxygenation chiefly by the oxygenase pathway. This rearrangement of oxygen utilization processes caused an increase in human high-altitude resistance. The use of the above drugs is a promising trend in the development of an adaptative response to hypoxia in persons engaged in hazardous jobs.
Nagornev
S N
SN
Sytnik
S I
SI
Bobrovnitskiĭ
I P
IP
Cherniakov
I N
IN
Shishov
A A
AA
D000222:Adaptation, Physiological; D000328:Adult; D000531:Altitude; D000532:Altitude Sickness / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism; D000924:Anticholesteremic Agents / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D000860:Hypoxia / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008954:Models, Biological; D018697:Nootropic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D010105:Oxygenases / Q000378:metabolism; D010889:Piracetam / Q000494:pharmacology / Q000627:therapeutic use; D011341:Probucol / Q000494:pharmacology / Q000627:therapeutic use
D000924:Anticholesteremic Agents; D000975:Antioxidants; D018697:Nootropic Agents; D010105:Oxygenases; D011341:Probucol; D010889:Piracetam
Farmakologicheskaia korrektsiia protsessa lipoperoksidatsii pri gipoksii i vozmozhnost' povysheniia vysotnoĭ ustoĭchivosti cheloveka s pomoshch'iu preparatov metabolicheskogo tipa deĭstviia.