High blood levels of macrophage colony-stimulating factor in preeclampsia.
In pregnancy, the decidual cells produce and secrete large amounts of macrophage colony-stimulating factor (M-CSF). M-CSF stimulates the proliferation and differentiation of trophoblasts. In addition, it stimulates them in a dose-dependent manner to produce certain hormones, such as human chorionic gonadotropin and human placental lactogen. Based on these facts, M-CSF is considered to be an essential cytokine for placental maintenance. Because placental dysfunction may sometimes result from preeclampsia, ascertaining blood M-CSF levels in preeclamptic patients would be of interest. The blood was collected from 33 subjects, of whom 19 were normal pregnant women and 14 were preeclamptic patients. The M-CSF level was determined by the sandwich enzyme-linked immunosorbent assay method using three antibodies. The investigators measured peripheral blood M-CSF levels in preeclamptic subjects and compared them with levels in subjects with normal pregnancies. This study showed that peripheral blood M-CSF levels were significantly higher in preeclamptic patients in the 30th and 38th weeks of pregnancy (P < .005). This is the first report concerning high M-CSF blood levels in preeclamptic patients.
Hayashi
M
M
Department of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine, Saitama, Japan.
Numaguchi
M
M
Watabe
H
H
Yaoi
Y
Y
D000328:Adult; D000933:Antifibrinolytic Agents / Q000378:metabolism; D000990:Antithrombin III / Q000032:analysis; D005260:Female; D005341:Fibrinolysin / Q000378:metabolism; D006801:Humans; D007958:Leukocyte Count; D018655:Lymphocyte Count; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood*; D009000:Monocytes / Q000166:cytology; D009504:Neutrophils / Q000166:cytology; D010447:Peptide Hydrolases / Q000032:analysis; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D000979:alpha-2-Antiplasmin
D000933:Antifibrinolytic Agents; D000979:alpha-2-Antiplasmin; C046193:antithrombin III-protease complex; C037742:plasmin-plasmin inhibitor complex; D016173:Macrophage Colony-Stimulating Factor; D000990:Antithrombin III; D010447:Peptide Hydrolases; D005341:Fibrinolysin