title: [Congenital diaphragmatic hernia: the use of ECMO and other modern therapeutic strategies].
abstract: Congenital diaphragmatic hernia (CDH) with severe respiratory failure is still associated with significant mortality. Modern treatment of CDH is now widely accepted to be delayed repair after stabilization. Availability of Extracorporeal Membrane Oxygenation (ECMO) led up to real improvement in survival. Several others modalities have been recently used in attempting to reduce the need for ECMO or, otherwise, to improve outcome. Multicenter controlled trial of high-frequency oscillatory ventilation (HFOV), exogenous surfactant replacement, nitric oxide (NO) inhalation and, more recently, liquid ventilation have been reported. We describe four cases of CDH treated in our ECMO-centre from 1993 to date, 25% surviving. One patient died by pulmonary hypertension and multiorgan failure while on ECMO; one by pulmonary hypertension and cardiac failure and one by sepsis, both ones far from effective ECMO weaning. All patients underwent extracorporeal bypass because of Oxygenation Index (OI) ranging 65-215. Venovenous has been always made but one patient needed early switching on venoarterial. Several trials with surfactant and nitric oxide were performed during extracorporeal bypass. In survived patient, diaphragmatic defect was repaired out of ECMO. Patients survived to the weaning underwent vascular reconstruction. Our ECMO data confirm worse prognosis for CDH rather than other ECMO requiring diseases (we report 66.7% surviving in overall ECMO application); we underline real improvement by using alternative therapies together with extracorporeal bypass and primary role of OI as predicting index for ECMO.
authors.affiliation: Dipartimento del Bambino, Università di Padova, Italia.
authors.forename: N
authors.initials: N
authors.lastname: Tommasoni
authors.forename: P G
authors.initials: PG
authors.lastname: Gamba
authors.forename: P
authors.initials: P
authors.lastname: Midrio
authors.forename: P
authors.initials: P
authors.lastname: Biban
authors.forename: A
authors.initials: A
authors.lastname: Pettenazzo
authors.forename: G F
authors.initials: GF
authors.lastname: Zanon
authors.forename: M
authors.initials: M
authors.lastname: Guglielmi
mesh_terms: D000280:Administration, Inhalation; D003131:Combined Modality Therapy; D015199:Extracorporeal Membrane Oxygenation; D017809:Fatal Outcome; D005260:Female; D006548:Hernia, Diaphragmatic / Q000628:therapy*; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009569:Nitric Oxide / Q000008:administration & dosage; D011663:Pulmonary Surfactants / Q000008:administration & dosage
chemical_list: D011663:Pulmonary Surfactants; D009569:Nitric Oxide
vernacular_title: Ernia congenita diaframmatica: impiego dell'ECMO e di altre moderne strategie terapeutiche.