Mosaic single plasma sample method for measuring glomerular filtration rate.
Seven single plasma sample methods for measuring glomerular filtration rate (GFR) were evaluated. When compared with GFRs calculated from a slope/intercept method proposed by Russell et al. [6] (using 1 h and 3 h plasma samples) as a reference standard, each single-sample method produced better results in different ranges of GFR (3 h plasma sample was used for all seven single-sample methods). Combining the best single-sample method in each range (mosaic) resulted in a regression line of y = 0.98x + 1.0, with a correlation coefficient of 0.980 and a standard error of estimate of 6.5 ml min-1 in 294 samples. This mosaic method yielded more accurate and realistic GFR values than any other individual single-sample method.
Kim
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Department of Nuclear Medicine, Mount Sinai Medical Center, New York, NY 10029, USA.
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D000293:Adolescent; D000328:Adult; D000368:Aged; D005919:Glomerular Filtration Rate; D006801:Humans; D008875:Middle Aged; D012044:Regression Analysis; D015203:Reproducibility of Results; D012984:Software; D016284:Technetium Tc 99m Pentetate / Q000097:blood*; D013997:Time Factors
D016284:Technetium Tc 99m Pentetate