title: Single- and multiple-dose pharmacokinetics and pharmacodynamics of leflunomide's active metabolite A77 1726 in normal Lewis rats.
authors.affiliation: Department of Cardiothoracic Surgery, Stanford University School of Medicine, California 94305-5247, USA.
authors.forename: H T
authors.initials: HT
authors.lastname: Silva
authors.forename: R
authors.initials: R
authors.lastname: Shorthouse
authors.forename: R E
authors.initials: RE
authors.lastname: Morris
mesh_terms: D000284:Administration, Oral; D000814:Aniline Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D000818:Animals; D003437:Crotonates; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006885:Hydroxybutyrates / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D007555:Isoxazoles / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D000077339:Leflunomide; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D008657:Metabolic Clearance Rate; D009570:Nitriles; D051381:Rats; D011917:Rats, Inbred Lew; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014052:Toluidines
chemical_list: D000814:Aniline Compounds; D003437:Crotonates; D006885:Hydroxybutyrates; D007166:Immunosuppressive Agents; D007555:Isoxazoles; D009570:Nitriles; D014052:Toluidines; C527525:teriflunomide; D004247:DNA; D000077339:Leflunomide; D013936:Thymidine