Evaluation of early graft function by hepatic venous hemoglobin oxygen saturation following orthotopic liver transplantation in the rat.
This study was designed to evaluate the use of hepatic venous oxygen saturation (Shvo2) as a predictor of early graft function after liver transplantation. We examined the levels of Shvo2 and serum ALT after transplantation using the isogeneic rat orthotopic liver transplant model. Shvo2 levels 2 hr after reperfusion in the 6-hr cold ischemia (nonviable allograft) group were significantly lower than those in the 1-hr and 3-hr cold ischemia (viable allograft) groups. However, there was no significant difference in ALT levels among these groups. These results suggest that decreased hepatic blood flow due to microcirculatory disturbances may occur in the nonviable allograft even in the early phase of reperfusion and may be responsible for ischemic damage to parenchymal cells. Therefore, Shvo2 could provide a simple index of the initial graft status and be useful for a rapid etiological diagnosis of early postoperative graft dysfunction and for estimating the graft outcome after liver transplantation.
Shimizu
H
H
The First Department of Surgery, School of Medicine, Chiba University, Chuo-ku, Japan.
Miyazaki
M
M
Ito
H
H
Nakagawa
K
K
Ambiru
S
S
Nakajima
N
N
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D005069:Evaluation Studies as Topic; D006454:Hemoglobins / Q000737:chemistry / Q000378:metabolism; D006503:Hepatic Veins / Q000737:chemistry*; D016031:Liver Transplantation / Q000502:physiology*; D008297:Male; D010100:Oxygen / Q000097:blood*; D051381:Rats; D011917:Rats, Inbred Lew; D013997:Time Factors
D006454:Hemoglobins; D000410:Alanine Transaminase; D010100:Oxygen