[Charge heterogeneity of low density lipoproteins].
Traditionally, low-density lipoprotein (LDL) are separated with respect to their size, density and apolipoprotein composition. Fractionation of LDL according to their electrical charge is also interesting as modified LDL have been implicated in the onset of atherosclerosis. This review discusses possible mechanisms underlying charge heterogeneity of human plasma LDL, such as oxidation, glycation, conjugation with aldehydes, carbamylation and changes in sialic acid content and protein composition.
Myara
I
I
Laboratoire de biochimie appliquée, faculté de pharmacie, Châtenay-Malabry, France.
Chappey
B
B
Demuth
K
K
Vedie
B
B
Pico
I
I
Moatti
N
N
D000447:Aldehydes / Q000378:metabolism; D018740:Genetic Heterogeneity; D006031:Glycosylation; D006801:Humans; D066298:In Vitro Techniques; D008077:Lipoproteins, LDL / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D010084:Oxidation-Reduction; D012794:Sialic Acids / Q000737:chemistry
D000447:Aldehydes; D008077:Lipoproteins, LDL; D012794:Sialic Acids
Hétérogénéité de charge des lipoprotéines de basse densité (LDL).