title: Structure and functional analysis of the multistress response gene DDR2 from Saccharomyces cerevisiae.
abstract: The DDR2 gene is a multistress response gene in Saccharomyces cerevisiae that is transcriptionally activated by more than thirteen xenobiotic agents and environmental or physiological stresses. The DDR2 gene encodes a small hydrophobic 61 amino acid polypeptide located on chromosome XV adjacent to the SPE2 locus. Disruption alleles of the DDR2 gene have been constructed and these ddr2 delta mutants show no defect in heat shock recovery or thermotolerance and appear normal for DNA damage sensitivity and mutagenesis.
authors.affiliation: Laboratory of Structural Biology and Molecular Medicine, UCLA School of Medicine 90024, USA.
authors.forename: N
authors.initials: N
authors.lastname: Kobayashi
authors.forename: T K
authors.initials: TK
authors.lastname: McClanahan
authors.forename: J R
authors.initials: JR
authors.lastname: Simon
authors.forename: J M
authors.initials: JM
authors.lastname: Treger
authors.forename: K
authors.initials: K
authors.lastname: McEntee
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002874:Chromosome Mapping; D004271:DNA, Fungal; D005656:Fungal Proteins / Q000235:genetics*; D005800:Genes, Fungal; D008969:Molecular Sequence Data; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins
chemical_list: C102893:DDR2 protein, S cerevisiae; D004271:DNA, Fungal; D005656:Fungal Proteins; D029701:Saccharomyces cerevisiae Proteins