title: Evidence of overload, dissolution and breakage of MMVF10 fibres in the RCC chronic inhalation study.
abstract: This paper describes (i) the evidence revealing the biological mechanisms underlying data from inhalation experiments at the Research and Consulting Company (RCC) (HESTERBERG et al. 1993); and (ii) the quantitative evaluation of the kinetic rates of these mechanisms using a mathematical model developed at the Institute of Occupational Medicine (IOM) (TRAN et al. 1994).
authors.affiliation: Institute of Occupational Medicine, Edinburgh, UK.
authors.forename: C L
authors.initials: CL
authors.lastname: Tran
authors.forename: A D
authors.initials: AD
authors.lastname: Jones
authors.forename: K
authors.initials: K
authors.lastname: Donaldson
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008168:Lung / Q000473:pathology*; D008433:Mathematics; D019016:Mineral Fibers / Q000032:analysis*; D008954:Models, Biological; D051381:Rats; D013997:Time Factors
chemical_list: D000336:Aerosols; D019016:Mineral Fibers