Virus-cell and cell-cell fusion.
Significant progress has been made in elucidating the mechanisms of viral membrane fusion proteins; both those that function at low, as well as those that function at neutral, pH. For many viral fusion proteins evidence now suggests that a triggered conformational change that exposes a previously cryptic fusion peptide, along with a rearrangement of the fusion protein oligomer, allows the fusion peptide to gain access to the target bilayer and thus initiate the fusion reaction. Although the topologically equivalent process of cell-cell fusion is less well understood, several cell surface proteins, including members of the newly described ADAM gene family, have emerged as candidate adhesion/fusion proteins.
Hernandez
L D
LD
Department of Cell Biology, University of Virginia, Charlottesville 22908, USA.
Hoffman
L R
LR
Wolfsberg
T G
TG
White
J M
JM
D002462:Cell Membrane; D008561:Membrane Fusion; D011993:Recombinant Fusion Proteins; D014760:Viral Fusion Proteins; D014780:Viruses
D011993:Recombinant Fusion Proteins; D014760:Viral Fusion Proteins