Derivatives of 2-mercaptobenzenesulphonamide. XVIII. Syntheses and cardiovascular effects of some S- and S,N-substituted 4-chloro-2-mercapto-5-methyl-N-(5-amino-1,2,4-triazol-3-yl) benzenesulphonamide derivatives.
The syntheses of salts [III, IV] and amides [V, V.HCl] of 2-[5-chloro-4-methyl-2-[(5-amino-s-triazol-3-yl)aminosulphonyl+ ++] phenylthio] alkanoic acids, as well as 5-amino-2-[2-(2,4-dimethylpiperidino) ethyl]-3-[4-chloro-2-[2-(2,6-dimethylpiperidino) ethylthio]-5-methylbenzenesulphonylimino]-1-methyl-delta 4-1,2,4-triazoline dihydrochloride [X] and 5-(amino-, 4-chloroanilino- or 3,4,5-trimethoxyanilino)-1,2-di[2-(2,6-dimethylpiperidino) ethyl]-3-(4-chloro-2-[2-(2,6-dimethylpiperidino) ethylthio]-5-methylbenzenesulphonylimino)-delta 4-1,2,4-triazoline trihydrochlorides [XI-XIII] are described. The results of preliminary pharmacological examinations such as acute toxicity and influence on circulatory system of compounds III, IV, V.HCl and X-XIII are presented. The antiarrhythmic effect of the most active [XI] was stronger or comparable to the reference drugs quinidine and procainamide.
Brzozowski
Z
Z
Department of Drug Technology, Medical University of Gdańsk, Poland.
Pomarnacka
E
E
Oledzka
K
K
Filczewski
M
M
D002731:4-Chloromercuribenzenesulfonate / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D017609:Barium Compounds; D002712:Chlorides; D006321:Heart / Q000187:drug effects*; D007928:Lethal Dose 50; D051379:Mice; D051381:Rats; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity
D000889:Anti-Arrhythmia Agents; D017609:Barium Compounds; D002712:Chlorides; D014230:Triazoles; C024986:barium chloride; D002731:4-Chloromercuribenzenesulfonate; D000157:Aconitine