The anti-HIV activity and mechanisms of action of pure compounds isolated from Rosa damascena.
Water and methanol extracts of Rosa damascena exhibited moderate anti-HIV activity. The anti-viral activities of 9 compounds isolated from the methanol extract were compared. The tetrahydroxyflavanone (kaempferol, 1), was effective in reducing the maturation of infectious progeny virus apparently due to selective inhibition of the viral protease. On the other hand the pentahydroxyflavone (quercetin, 2) and two 3-substituted derivatives of kaempferol appeared to inhibit HIV-infection by preventing binding of gp120 to CD4. 2-Phenylethanol-O-(6-O-galloyl)-beta-D-glucopyranoside 8 interacted irreversibly with gp120 and neutralized virus infectivity. The differences in the modes of action of 1 and 8 can account for the apparent synergy of their anti-viral activities.
Mahmood
N
N
MRC Collaborative Centre, London, United Kingdom.
Piacente
S
S
Pizza
C
C
Burke
A
A
Khan
A I
AI
Hay
A J
AJ
D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology*; D015704:CD4 Antigens / Q000378:metabolism; D002478:Cells, Cultured; D005707:Gallic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000494:pharmacology; D015699:HIV Envelope Protein gp120 / Q000378:metabolism; D017320:HIV Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects* / Q000254:growth & development; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D011485:Protein Binding; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
C102621:2-phenylethanol-O-(6-O-galloyl)glucopyranoside; D019380:Anti-HIV Agents; D015704:CD4 Antigens; D005960:Glucosides; D015699:HIV Envelope Protein gp120; D017320:HIV Protease Inhibitors; D010936:Plant Extracts; D005707:Gallic Acid