Severe anemia in a patient with isolated adrenocorticotropin deficiency.
A 64-year-old man was referred to our hospital for evaluation of progressive anemia. On admission, he had a severe normocytic normochromic anemia [hemoglobin 7.5 g/dl] requiring a blood transfusion. Endocrinological studies demonstrated an isolated ACTH deficiency. After receiving glucocorticoid replacement therapy, his anemia was rapidly corrected, his hematocrit and hemoglobin remained elevated for approximately 4 months. We present evidence that glucocorticoid plays an important role in the physiological regulation of human erythropoiesis.
Ihara
T
T
Second Department of Internal Medicine, Shiga University of Medical Science.
Tsujikawa
T
T
Hodohara
K
K
Inoue
H
H
Fujiyama
Y
Y
Bamba
T
T
Okabe
H
H
D000324:Adrenocorticotropic Hormone / Q000172:deficiency*; D000753:Anemia, Refractory / Q000097:blood / Q000209:etiology* / Q000628:therapy; D001803:Blood Transfusion; D004920:Erythropoiesis; D005938:Glucocorticoids / Q000008:administration & dosage; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged
D005938:Glucocorticoids; D006454:Hemoglobins; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone