Malignant hyperthermia-like reaction secondary to ingestion of hops in five dogs.
Five dogs, 4 of which were Greyhounds, suffered adverse effects secondary to the ingestion of spent hops. Mean time to onset of clinical signs was 3 hours, and clinical signs included marked hyperthermia, restlessness, panting, vomiting, signs of abdominal pain, and seizures. Four of the 5 dogs died despite aggressive therapeutic measures, and there was rapid onset of rigor mortis in 3. The overrepresentation of Greyhounds, coupled with the clinical signs, was suggestive of a malignant hyperthermia-like response to the ingestion of hops. It also is possible that hops contain an uncoupler of oxidative phosphorylation.
Duncan
K L
KL
National Animal Poison Control Center (presently the ASPCA National Animal Poison Control Center), College of Veterinary Medicine, University of Illinois, Urbana 61801, USA.
Hare
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WR
Buck
W B
WB
D000818:Animals; D004283:Dog Diseases / Q000209:etiology*; D004285:Dogs; D005260:Female; D008297:Male; D008305:Malignant Hyperthermia / Q000209:etiology / Q000662:veterinary*; D010939:Plant Poisoning / Q000150:complications / Q000209:etiology / Q000662:veterinary*; D010945:Plants, Edible; D010946:Plants, Medicinal