Cyclosporine nephrotoxicity evaluated by tissue calcium deposition and tubular enzymes is prevented by L-propionylcarnitine in isolated perfused rat kidney.
Giovannini
L
L
Pharmacology Institute, University of Pisa, Italy.
Palla
R
R
Bertelli
A A
AA
Migliori
M
M
Panichi
V
V
Andreini
B
B
De Pietro
S
S
Bertelli
A
A
D000118:Acetylglucosaminidase / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D002331:Carnitine / Q000031:analogs & derivatives* / Q000494:pharmacology; D016572:Cyclosporine / Q000037:antagonists & inhibitors / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D007166:Immunosuppressive Agents / Q000037:antagonists & inhibitors / Q000633:toxicity*; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D007684:Kidney Tubules / Q000201:enzymology*; D008297:Male; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007166:Immunosuppressive Agents; C003223:propionylcarnitine; D016572:Cyclosporine; D000118:Acetylglucosaminidase; D002331:Carnitine; D002118:Calcium