[Clinical significance of free hemoglobin in blood serum in viral hepatitis].
Blood serum levels of extraerythrocytic hemoglobin (EEHb) were measured by the hemoglobin cyanide method in 71 patients with acute viral hepatitis B over the course of the disease. The mean values of this parameter in 30 normal subjects were found to be 0.67 +/- 0.03 g/l. In the patients in the acute period of hepatitis (weeks 1-2 of jaundice) EEHb levels were drastically elevated, particularly so in grave cases (2.36 +/- 0.22 g/l), though even in benign cases this value surpassed the norm twofold. As the jaundice regressed, EEHb levels somewhat lowered, though persisted rather high. EEHb content normalized by discharge from hospital only in the patients with the mild form of acute viral hepatitis B. The studies have revealed the prognostic value of this parameter that reflects the level of intravascular hemolysis. The authors suggest the major role of elevated red cell hemolysis in the pathogenesis of the increase of free bilirubin level in the blood in acute viral hepatitis B.
Levina
L D
LD
Bezuglova
I A
IA
Bezuglov
D A
DA
D001663:Bilirubin / Q000097:blood; D006452:Hemoglobinometry / Q000379:methods*; D006454:Hemoglobins; D006525:Hepatitis, Viral, Human / Q000097:blood / Q000175:diagnosis*; D006801:Humans
D006454:Hemoglobins; C011207:cyanhemoglobin; D001663:Bilirubin
Klinicheskoe znachenie issledovaniia svobodnogo gemoglobina v syvorotke krovi pri virusnom gepatite.