title: Malignant hyperthermia-like reaction secondary to ingestion of hops in five dogs.
abstract: Five dogs, 4 of which were Greyhounds, suffered adverse effects secondary to the ingestion of spent hops. Mean time to onset of clinical signs was 3 hours, and clinical signs included marked hyperthermia, restlessness, panting, vomiting, signs of abdominal pain, and seizures. Four of the 5 dogs died despite aggressive therapeutic measures, and there was rapid onset of rigor mortis in 3. The overrepresentation of Greyhounds, coupled with the clinical signs, was suggestive of a malignant hyperthermia-like response to the ingestion of hops. It also is possible that hops contain an uncoupler of oxidative phosphorylation.
authors.affiliation: National Animal Poison Control Center (presently the ASPCA National Animal Poison Control Center), College of Veterinary Medicine, University of Illinois, Urbana 61801, USA.
authors.forename: K L
authors.initials: KL
authors.lastname: Duncan
authors.forename: W R
authors.initials: WR
authors.lastname: Hare
authors.forename: W B
authors.initials: WB
authors.lastname: Buck
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000209:etiology*; D004285:Dogs; D005260:Female; D008297:Male; D008305:Malignant Hyperthermia / Q000209:etiology / Q000662:veterinary*; D010939:Plant Poisoning / Q000150:complications / Q000209:etiology / Q000662:veterinary*; D010945:Plants, Edible; D010946:Plants, Medicinal