Status epilepticus following intravenous N-acetylcysteine therapy.
A previously healthy 2 1/2-year-old girl developed status epilepticus followed by cortical blindness during intravenous N-acetylcysteine therapy for paracetamol ingestion. The child's vision was almost completely recovered during the 18 months follow-up period. We assume that the cortical blindness was a postictal sequela after prolonged seizure episode, most probably due to respiratory depression induced by N-acetylcysteine.
Hershkovitz
E
E
Division of Pediatrics, Soroka Medical Center, Beer Sheva, Israel.
Shorer
Z
Z
Levitas
A
A
Tal
A
A
D000082:Acetaminophen / Q000506:poisoning*; D000111:Acetylcysteine / Q000009:adverse effects*; D018712:Analgesics, Non-Narcotic / Q000506:poisoning*; D000927:Anticonvulsants / Q000627:therapeutic use; D001766:Blindness / Q000139:chemically induced*; D002675:Child, Preschool; D005260:Female; D016166:Free Radical Scavengers / Q000009:adverse effects*; D006801:Humans; D007262:Infusions, Intravenous; D010634:Phenobarbital / Q000627:therapeutic use; D013226:Status Epilepticus / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology
D018712:Analgesics, Non-Narcotic; D000927:Anticonvulsants; D016166:Free Radical Scavengers; D000082:Acetaminophen; D000111:Acetylcysteine; D010634:Phenobarbital