title: [Iodine-125-brachytherapy of malignant choroid melanoma. II: Long-term functional outcome].
abstract: BACKGROUND
  Following I-125 brachytherapy of choroidal melanoma, a good primary postoperative visual acuity results. The aim of this study is to evaluate postoperative, longterm visual acuity answering the following questions: 1) When do radiogenic complications begin to develop; 2) How long does the postoperative visual acuity remain stable; 3) Is there a difference if the treated tumor is < or = or > 3 mm off the disc and foveola respectively.
  
  
  METHODS
  Between 12/1984-12/1989, 19 patients were treated with I-125 brachytherapy for choroidal melanoma. Height of tumor was x 5.8 mm, maximum base diameter x 11.6 mm. In 10 eyes (group A), the posterior tumor border was < or = 3 mm off the disc and foveola respectively, in 9 (group B) > 3 mm. The plaque was in situ x 7.5 days, apical radiation dose x 70 Gy, and scleral contact dose x 355 Gy. Follow-up ranged at x 6.3 years.
  
  
  RESULTS
  Between preoperative visual acuity in group A and group B there was a statistically significant difference (p < 0.05), which remained stable 1 1/2 years postoperatively. Subsequent deterioration of visual acuity occurred later in group B than in group A, but was present after 4 1/2 years in all patients and ranged at < or = 20/400. This decrease was due to subsequent radiogenic oculopathy.
  
  
  CONCLUSIONS
  Radiogenic complications following I-125 brachytherapy begin within the first 6 months. In group B visual acuity deteriorated later, but after 4 1/2 years, it decreased due to radiogenic oculopathy to 20/400 in all patients. Prospective longterm studies are needed to evaluate whether I-125 should be indicated for larger melanomas and Ruthenium-106 for smaller melanomas to obtain better longterm visual results.
authors.affiliation: Abt. Augenheilkunde III: Netzhaut und Glaskörperchirurgie, Universität Tübingen.
authors.forename: I
authors.initials: I
authors.lastname: Kreissig
authors.forename: D
authors.initials: D
authors.lastname: Rose
authors.forename: E
authors.initials: E
authors.lastname: Simader
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000379:methods*; D002830:Choroid Neoplasms / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008545:Melanoma / Q000532:radiotherapy*; D008875:Middle Aged; D011832:Radiation Injuries / Q000209:etiology; D011879:Radiotherapy Dosage; D014792:Visual Acuity / Q000528:radiation effects
chemical_list: D007457:Iodine Radioisotopes
vernacular_title: Jod-125-Brachytherapie des malignen Aderhautmelanoms. Teil II: Funktionelle Langzeitergebnisse.