title: [Secondary neovascularization--one of the steps in the development and progression of breast cancer].
abstract: Published data on the role of microcirculation and secondary neovascularization in line with immune, coagulating and anticoagulating effects in the development of breast carcinoma have been analyzed. Multifactorial influences realized through a microcirculatory bed determine a dynamic formation of tumor cells heterogeneity, the appearance of new clones including those with characteristic biological properties (capacity of metastasizing). Secondary neovascularization determining the carcinoma genesis at its different stages, ability to metastasize and invade affects tumor prognosis.
authors.forename: D V
authors.initials: DV
authors.lastname: Kozlov
authors.forename: N A
authors.initials: NA
authors.lastname: Zorin
authors.forename: O A
authors.initials: OA
authors.lastname: Golubev
mesh_terms: D001943:Breast Neoplasms / Q000098:blood supply / Q000473:pathology*; D002999:Clone Cells; D018450:Disease Progression; D005260:Female; D006801:Humans; D008833:Microcirculation / Q000648:ultrastructure; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic
vernacular_title: Vtorichnyĭ neoangiogenez--odno iz zven'ev stanovleniia i progressii raka molochnoĭ zhelezy.