In vitro swelling studies and preliminary biocompatibility evaluation of acrylamide-based hydrogels.
In this in vitro study, the biocompatibility of acrylamide-based hydrogels such as acrylamide/crotonic and acrylamide/itaconic acid, prepared by using gamma-rays, has been investigated against some biochemical parameters of human serum. The swelling kinetics of acrylamide/crotonic and acrylamide/itaconic acid hydrogels are investigated in distilled water and physiological saline solution and some swelling and diffusion parameters have been calculated. For the analysis of biocompatibility, acrylamide/crotonic and acrylamide/itaconic acid hydrogels are incubated in 10 different human sera for 24 h and their biocompatibilities with some biochemical parameters have been investigated. No significant difference in values before and after the test procedures have been found. It is therefore concluded that acrylamide/crotonic and acrylamide/itaconic acid hydrogels are biocompatible.
Karadağ
E
E
Chemistry Department, Cumhuriyet University, Sivas, Turkey.
Saraydin
D
D
Cetinkaya
S
S
Güven
O
O
D020106:Acrylamide; D000178:Acrylamides / Q000737:chemistry / Q000378:metabolism*; D001672:Biocompatible Materials / Q000592:standards; D001798:Blood Proteins / Q000378:metabolism*; D003437:Crotonates / Q000737:chemistry* / Q000378:metabolism; D004058:Diffusion; D005782:Gels; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D011485:Protein Binding; D013386:Succinates / Q000737:chemistry* / Q000378:metabolism
D000178:Acrylamides; D001672:Biocompatible Materials; D001798:Blood Proteins; D003437:Crotonates; D005782:Gels; D013386:Succinates; D020106:Acrylamide; C005229:itaconic acid