[The expression of adhesion molecules on eosinophils from atopic and non-atopic subjects].
The accumulation of eosinophils in the airway is one of the characteristics seen in patients with chronic asthma. There is now considerable evidence that airway eosinophilia is associated with the development of late asthmatic response (LAR) and bronchial hyperresponsiveness. In this study, we observed PAF induced up-regulation of inducible adhesion molecules Mac-1 and LFA-1 beta on eosinophils of atopic patients compared with non-atopic and normal subjects. In conclusion, we found that adhesion molecule expression is different between atopic and non-atopic patients. Therefore, adhesion molecule expression is thought to be important in the prolonging and pathogenesis of allergic inflammation.
Li
J
J
Department of Medicine and Clinical Immunology, Dokkyo University School of Medicine.
Sagara
H
H
Fukuda
T
T
Makino
S
S
D000328:Adult; D000368:Aged; D018941:Antigens, CD19 / Q000097:blood; D001249:Asthma / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood*; D004804:Eosinophils / Q000737:chemistry* / Q000502:physiology; D005260:Female; D006684:HLA-DR Antigens / Q000097:blood; D006801:Humans; D006967:Hypersensitivity / Q000097:blood* / Q000503:physiopathology; D039041:Integrin alpha4beta1; D016023:Integrins / Q000097:blood; D016169:Lymphocyte Function-Associated Antigen-1 / Q000097:blood; D016177:Macrophage-1 Antigen / Q000097:blood; D008297:Male; D008875:Middle Aged; D016201:Receptors, Lymphocyte Homing / Q000097:blood; D006255:Rhinitis, Allergic, Seasonal / Q000097:blood
D018941:Antigens, CD19; D015815:Cell Adhesion Molecules; D006684:HLA-DR Antigens; D039041:Integrin alpha4beta1; D016023:Integrins; D016169:Lymphocyte Function-Associated Antigen-1; D016177:Macrophage-1 Antigen; D016201:Receptors, Lymphocyte Homing