[Osteoporosis induced either by unfractionated heparin or by low molecular weight heparin].
Since the first suggestion of heparin-induced osteoporosis in 1963, a large body of work has been published. The mechanism can be explained by the effect of heparin as a cofactor for physiological stimulators of osteoclasts. Low-molecular weight heparins are an interesting alternative to non-fractionate heparin as the risk is reduced with an equivalent anticoagulation activity. Prevention is based on screening for patients at risk, preferential use of low-molecular weight heparins, early switch to anti-vitamin K and vitamin and calcium supplementation in pregnant women an elderly subjects. Curative treatment combines vitamin-calcium supplementation with inhibitors of bone resorption.
Chigot
P
P
Laboratorie d'Hématologie, Hôtel-Dieu de Paris.
De Gennes
C
C
Samama
M M
MM
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006493:Heparin / Q000009:adverse effects*; D006495:Heparin, Low-Molecular-Weight / Q000009:adverse effects*; D006801:Humans; D010010:Osteoclasts / Q000187:drug effects; D010024:Osteoporosis / Q000139:chemically induced* / Q000517:prevention & control / Q000628:therapy; D011247:Pregnancy; D012307:Risk Factors
D006495:Heparin, Low-Molecular-Weight; D006493:Heparin
Ostéoporose induite soit par l'héparine non fractionnée soit par l'héparine de bas poids moléculaire.