title: A freeze-dried injectable form of ibuprofen: development and optimisation using response surface methodology.
abstract: In this study a complex of Ibuprofen and b-Hydroxypropylcyclodextrin was prepared employing a freeze drying method. The production parameters and the final specifications of this product were optimized by using response surface methodology. The results show that the freeze dried complex meets the requirements for solubility to be considered as a possible injectable form.
authors.affiliation: Department of Pharmacy, University of Athens, Greece.
authors.forename: K A
authors.initials: KA
authors.lastname: Kagkadis
authors.forename: D M
authors.initials: DM
authors.lastname: Rekkas
authors.forename: P P
authors.initials: PP
authors.lastname: Dallas
authors.forename: N H
authors.initials: NH
authors.lastname: Choulis
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D003505:Cyclodextrins; D005612:Freeze Drying; D007052:Ibuprofen / Q000008:administration & dosage* / Q000737:chemistry; D007267:Injections; D012995:Solubility; D047392:beta-Cyclodextrins
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003505:Cyclodextrins; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D007052:Ibuprofen