Dihydroorotate dehydrogenase is a target for the biological effects of leflunomide.
Williamson
R A
RA
Hoechst Marion Roussel, Covingham, Swindon, UK.
Yea
C M
CM
Robson
P A
PA
Curnock
A P
AP
Gadher
S
S
Hambleton
A B
AB
Woodward
K
K
Bruneau
J M
JM
Hambleton
P
P
Spinella-Jaegle
S
S
Morand
P
P
Courtin
O
O
Sautés
C
C
Westwood
R
R
Hercend
T
T
Kuo
E A
EA
Ruuth
E
E
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002478:Cells, Cultured; D000090722:Dihydroorotate Dehydrogenase; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007425:Intracellular Membranes / Q000201:enzymology; D007555:Isoxazoles / Q000494:pharmacology*; D000077339:Leflunomide; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects / Q000201:enzymology* / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D008861:Microsomes / Q000201:enzymology; D008928:Mitochondria / Q000201:enzymology; D008969:Molecular Sequence Data; D010088:Oxidoreductases / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D044925:Oxidoreductases Acting on CH-CH Group Donors; D010446:Peptide Fragments / Q000737:chemistry; D051381:Rats; D017386:Sequence Homology, Amino Acid; D013154:Spleen / Q000276:immunology
D000090722:Dihydroorotate Dehydrogenase; D007166:Immunosuppressive Agents; D007555:Isoxazoles; D010446:Peptide Fragments; D010088:Oxidoreductases; D044925:Oxidoreductases Acting on CH-CH Group Donors; D000077339:Leflunomide