ATP release by angiotensin II from segments and cultured smooth muscle cells of guinea-pig taenia coli.
Effects of angiotensin II on ATP release were evaluated in segments and cultured smooth muscle cells from the guinea-pig taenia coli. In the segments, angiotensin II (0.3-3 microM) elicited release of ATP which was blocked by losartan and SC-52458, non-peptide angiotensin II type-1 receptor (AT1)-antagonists, but not by PD-123319, an AT2-antagonist. In superfused cultured cells, 10 microM angiotensin II likewise elicited release of ATP. Again the response was blocked by losartan and SC-52458 but not by PD-123319. These findings suggest that angiotensin II releases ATP from the smooth muscles by activation of angiotensin II-, presumably AT1-, receptors.
Katsuragi
T
T
Department of Pharmacology, School of Medicine, Fukuoka University, Japan.
Tamesue
S
S
Sato
C
C
Sato
Y
Y
Furukawa
T
T
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D005260:Female; D006168:Guinea Pigs; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects*; D008297:Male; D009130:Muscle, Smooth / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D011945:Receptors, Angiotensin / Q000187:drug effects / Q000502:physiology
D011945:Receptors, Angiotensin; D000804:Angiotensin II; D000255:Adenosine Triphosphate