title: Changes in L1 antigen expression in the rat striatum after substantia nigra lesions.
abstract: L1 antigen promotes neurite outgrowth from dopaminergic neurons in tissue culture. In the present study, we examined the effects of dopaminergic deafferentation of the striatum on L1 expression. In the medial-periventricular part of the striatum, both complete and partial substantia nigra (SN) lesions decreased L1 expression. Complete lesions increased L1 expression in the dorso-medial and ventro-lateral parts of the striatum on the lesioned side when compared with that on the non-lesioned side. The decrease in the ventro-lateral area was maintained in animals examined three months after the lesioning. Animals with partial SN lesions showed a different pattern of altered L1 expression. After frontal cortex lesions, changes in L1 expression also occur preferentially in the dorso-medial and periventricular striatum. Therefore, the results indicate a complex regulation of L1 expression after damage of striatal circuitry, manifested by a preferential occurrence of changes in periventricular regions.
authors.affiliation: Section on Preclinical Neuroscience, NIMH Neuroscience Center at St. Elizabeths, Washington, D.C. 20032, USA.
authors.forename: M
authors.initials: M
authors.lastname: Poltorak
authors.forename: J R
authors.initials: JR
authors.lastname: Williams
authors.forename: K D
authors.initials: KD
authors.lastname: Moore
authors.forename: W J
authors.initials: WJ
authors.lastname: Freed
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000378:metabolism*; D003714:Denervation; D004298:Dopamine / Q000378:metabolism / Q000502:physiology; D039841:Leukocyte L1 Antigen Complex; D017072:Neostriatum / Q000378:metabolism*; D019006:Neural Cell Adhesion Molecules / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013378:Substantia Nigra / Q000502:physiology*
chemical_list: D000954:Antigens, Surface; D039841:Leukocyte L1 Antigen Complex; D019006:Neural Cell Adhesion Molecules; D004298:Dopamine