title: Identification and molecular cloning of a 67-kilodalton protein in Schistosoma japonicum homologous to a family of actin-binding proteins.
abstract: A monoclonal antibody to Schistosoma japonicum which conferred significant protection against cercarial challenge in mice was produced. The predicted translation product of the cDNA corresponding to the antigen recognized by this antibody was homologous to a newly identified family of actin-binding proteins. The expressed protein bound polymerized actin and was recognized by serum from patients infected with S. japonicum.
authors.affiliation: International Health Institute, Brown University, Providence, Rhode Island, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Kurtis
authors.forename: B L
authors.initials: BL
authors.lastname: Ramirez
authors.forename: P M
authors.initials: PM
authors.lastname: Wiest
authors.forename: K L
authors.initials: KL
authors.lastname: Dong
authors.forename: A
authors.initials: A
authors.lastname: El-Meanawy
authors.forename: M M
authors.initials: MM
authors.lastname: Petzke
authors.forename: J H
authors.initials: JH
authors.lastname: Johnson
authors.forename: J
authors.initials: J
authors.lastname: Edmison
authors.forename: R A
authors.initials: RA
authors.lastname: Maier
authors.forename: G R
authors.initials: GR
authors.lastname: Olds
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000909:Antibodies, Helminth / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000947:Antigens, Helminth / Q000235:genetics*; D001483:Base Sequence; D001798:Blood Proteins / Q000235:genetics; D003001:Cloning, Molecular; D003598:Cytoskeletal Proteins; D015801:Helminth Proteins / Q000235:genetics*; D007116:Immunization, Passive; D008565:Membrane Proteins / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D008840:Microfilament Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000235:genetics; D012549:Schistosoma japonicum / Q000235:genetics*; D012554:Schistosomiasis japonica / Q000517:prevention & control; D017386:Sequence Homology, Amino Acid; D000099149:Ezrin
chemical_list: D000909:Antibodies, Helminth; D000911:Antibodies, Monoclonal; D000947:Antigens, Helminth; D001798:Blood Proteins; D003598:Cytoskeletal Proteins; D015801:Helminth Proteins; D008565:Membrane Proteins; D008840:Microfilament Proteins; D010750:Phosphoproteins; D000099149:Ezrin; C103355:JF antigen, Schistosoma japonicum; C071776:radixin