[The effect of naloxone on rhythm disorders and on the conduction system of the heart].
In experimental arrhythmias induced in rabbits by strophanthin, epinephrine, and calcium chloride the high antiarrhythmic efficacy of Naloxone was proved. No antiarrhythmic activity of Naloxone was observed in aconitine models. The intravenous administration of Naloxone to normal adults (0.4 - 0.8 mg) increased the sinus cycle length, sinus node recovery time (SNRT), CSNRT, and sinoatrial conduction time.
Shliakhto
E V
EV
Zaĭtsev
A A
AA
Panov
A V
AV
Ardashev
A V
AV
Nifontov
E M
EM
Kashina
E A
EA
Kazarin
V V
VV
Ivanov
V V
VV
D000328:Adult; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D002304:Cardiac Pacing, Artificial; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography / Q000187:drug effects; D006329:Heart Conduction System / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D009270:Naloxone / Q000494:pharmacology* / Q000627:therapeutic use*; D011817:Rabbits; D012016:Reference Values
D000889:Anti-Arrhythmia Agents; D009270:Naloxone
Vliianie naloksona na narusheniia ritma i provodiashchuiu sistemu serdtsa.