The effect of aminoglycoside-induced adaptive resistance on the antibacterial activity of other antibiotics against Pseudomonas aeruginosa in vitro.
The effect of gentamicin-induced adaptive resistance on the antibacterial activity of six non-aminoglycoside antibiotics was studied. Adaptive resistance was induced in Pseudomonas aeruginosa in a dynamic in-vitro model of infection. The bactericidal effect of ceftazidime, imipenem, aztreonam, ciprofloxacin, and piperacillin was not altered in the presence of adaptive resistance but the effect of rifampicin was increased.
Barclay
M L
ML
Department of Clinical Pharmacology, Christchurch Hospital, New Zealand.
Begg
E J
EJ
Chambers
S T
ST
Peddie
B A
BA
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001398:Aztreonam / Q000494:pharmacology; D002442:Ceftazidime / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D015169:Colony Count, Microbial; D004352:Drug Resistance, Microbial; D005839:Gentamicins / Q000494:pharmacology*; D015378:Imipenem / Q000494:pharmacology; D010878:Piperacillin / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000254:growth & development; D012293:Rifampin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D002939:Ciprofloxacin; D015378:Imipenem; D002442:Ceftazidime; D001398:Aztreonam; D012293:Rifampin; D010878:Piperacillin