title: Gender specific alterations in antioxidant status of aging Zaprionus paravittiger fed on propyl gallate.
abstract: Zaprionus paravittiger fed on propyl gallate (PG) supplemented diet (2.5, 25 and 250 micrograms/ml) showed an increase in life span. Further increase in concentration (2500, 5000 and 7500 micrograms/ml) accelerated the mortality rate. Females exhibited longer life span as compared to males. Antioxidant enzymes (catalase, peroxidase and glutathione reductase) were measured in control and optimum concentration of PG (25 micrograms/ml) fed flies at various age intervals. Antioxidant enzyme activities showed an increase during reproductive phase. Catalase and glutathione reductase activities decreased with age however no significant change was observed in peroxidase activity. The females exhibited higher enzyme activities as compared to males in control and PG fed group at most of the age intervals. PG feeding caused a significant increase in catalase and glutathione reductase activities in both the sexes. These findings suggest the PG has dose dependent and sex specific influence on longevity of Z. paravittiger and support the view that longevity and activity of antioxidant enzymes are positively linked.
authors.affiliation: Department of Pathology, University of Calgary, AB, Canada.
authors.forename: J S
authors.initials: JS
authors.lastname: Bains
authors.forename: R
authors.initials: R
authors.lastname: Kakkar
authors.forename: S P
authors.initials: SP
authors.lastname: Sharma
mesh_terms: D000375:Aging; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D018428:Drosophilidae; D005260:Female; D005978:Glutathione / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D009195:Peroxidase / Q000378:metabolism; D011435:Propyl Gallate / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D011435:Propyl Gallate; D002374:Catalase; D009195:Peroxidase; D005980:Glutathione Reductase; D005978:Glutathione