[Intractable hiccup in two severely handicapped patients during phenytoin therapy].
Two severely handicapped patients developed intractable hiccup during phenytoin therapy. In these two patients, serum phenytoin levels revealed 32.6 micrograms/ml and 17.6 micrograms/ml, respectively. Since large doses of phenytoin cause delayed latencies, and depressed or lost of brainstem auditory evoked potentials, it can be speculated that intractable hiccup could occur through dysfunction of brainstem by phenytoin.
Nishimura
M
M
Department of Pediatrics, National Sanatorium, Nagara Hospital, Gifu.
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D001933:Brain Stem / Q000187:drug effects; D006233:Persons with Disabilities; D006606:Hiccup / Q000139:chemically induced*; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000009:adverse effects*
D000927:Anticonvulsants; D010672:Phenytoin