[A case of acute nimodipine poisoning. Cardiac and vascular effects].
The authors report a clinical case of acute poisoning after ingestion of nimodipine. The patient, pulseless with a reduced level of consciousness and a third degree AV block, was treated with calcium salts, high doses of dopamine and temporary cardiac pacing. Nimodipine, a nifedipine-like calcium channel blocker, is widely used in cerebrovascular diseases with a low incidence of side effect. No cases of acute poisoning are reported in the literature. The possibility of loss of selectivity at higher doses suggests a cautious use of the drug in patients with alterations of AV conduction.
De Sio
A
A
Servizio di Anestesia e Rianimazione, USL 22-Ospedale S. Maria delle Grazie, Pozzuoli Napoli.
De Blasio
E
E
Alaggio
M C
MC
Claverini
D
D
Sibilio
G
G
D000368:Aged; D002121:Calcium Channel Blockers / Q000009:adverse effects*; D006331:Heart Diseases / Q000139:chemically induced*; D006801:Humans; D008297:Male; D009553:Nimodipine / Q000009:adverse effects*; D014652:Vascular Diseases / Q000139:chemically induced*
D002121:Calcium Channel Blockers; D009553:Nimodipine
Su di un caso di intossicazione acuta da nimopidina. Effetti cardiaci e vascolari.