title: Effect of chronic restraint stress on dendritic spines and excrescences of hippocampal CA3 pyramidal neurons--a quantitative study.
abstract: Effect of chronic restraint stress on the number of dendritic spines and excrescences of hippocampal CA3 pyramidal neurons has been investigated. The results revealed a significant increase in the number of dendritic spines of apical and basal dendrites in rats subjected to restraint stress (6 h per day for 21 days). The number of excrescences were also markedly increased in stressed rats. The physiological significance and possible mechanism for increased spine density is discussed.
authors.affiliation: Department of Neurophysiology, National Institute of Mental Health and NeuroSciences, Bangalore, India.
authors.lastname: Sunanda
authors.forename: M S
authors.initials: MS
authors.lastname: Rao
authors.forename: T R
authors.initials: TR
authors.lastname: Raju
mesh_terms: D000818:Animals; D002908:Chronic Disease; D003712:Dendrites / Q000648:ultrastructure*; D006624:Hippocampus / Q000473:pathology*; D008297:Male; D009474:Neurons / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000473:pathology*