[Effect of lomefloxacin on the functional activity of the phagocytic system].
The in vitro effect of lomefloxacin on the absorption activity of macrophages with respect to Mycobacterium tuberculosis and chemiluminescence of the phagocytizing cells was studied with the use of a wide range of the antibiotic concentrations. Lomefloxacin was shown to have no inhibitory effect on the phagocytic activity of the pulmonary macrophages and on the formation of active oxygen in the phagocytizing cells for the realization of the bactericidal action on M. tuberculosis.
Mozhokina
G N
GN
Gracheva
M P
MP
Sokolova
G B
GB
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D024841:Fluoroquinolones; D008163:Luminescent Measurements; D016676:Macrophages, Alveolar / Q000187:drug effects*; D051379:Mice; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010100:Oxygen / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects*; D015363:Quinolones / Q000494:pharmacology*
D000890:Anti-Infective Agents; D000995:Antitubercular Agents; D024841:Fluoroquinolones; D015363:Quinolones; C053091:lomefloxacin; D010100:Oxygen
Vliianie lomefloksatsina na funktsional'nuiu aktivnost' kletok fagotsitarnoĭ sistemy.