title: [Reactivity and immunogenicity of Havrix 360 vaccine for hepatitis A].
abstract: The reactogenicity and immunogenicity of a new vaccine against viral hepatitis A, under the name HAVRIX, manufactured by SmithKline Beecham Biologicals, Belgium, was studied. A single dose of 1 ml contains not less than 360 ELISA units of inactivated HAV, strain HM175, cultivated on human diploid cells. The vaccine has been applied intramuscularly to 80 second-grade primary school children under the 0, 1 and 6-month schedule. Postvaccinal reactions were followed for three days after each application of the vaccine. They were generally mild and present in less than 5% of the vaccinees (local as well as general). One month after the last vaccination the seroconversion was 100% in the anti HAV antibody test (HAVAB-ABBOT), the antibody level being over 500 IU/I, in 98% of the vaccinees. In conclusion, the tested vaccine is perfectly acceptable from both aspects, postvaccinal reactions and conferred protection. As the hepatitis A morbidity in Croatia has never been as low as in the last few years, the eventual introduction of this vaccination into the EPI is questionable.
authors.affiliation: Hrvatski zavod za javno zdravstvo, Zagreb.
authors.forename: B
authors.initials: B
authors.lastname: Borcić
authors.forename: S
authors.initials: S
authors.lastname: Kovac
authors.forename: I
authors.initials: I
authors.lastname: Mihaljević
authors.forename: V
authors.initials: V
authors.lastname: Dobrovsak-Sourek
authors.forename: M
authors.initials: M
authors.lastname: Ljubicić
mesh_terms: D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines; D017957:Hepatitis A Virus, Human / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000096:biosynthesis; D006801:Humans; D015164:Vaccines, Inactivated / Q000009:adverse effects / Q000276:immunology; D014761:Viral Hepatitis Vaccines / Q000009:adverse effects / Q000276:immunology*
chemical_list: D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines; D006508:Hepatitis Antibodies; D015164:Vaccines, Inactivated; D014761:Viral Hepatitis Vaccines
vernacular_title: Reaktogenost i imunogenost "Havrix 360" vakcine protiv hepatitisa A.