title: Pharmacokinetic model of dioxin and furan levels in adipose tissue from sawmill work involving chlorophenate fungicides.
abstract: Sawmill workers in British Columbia (B.C.), Canada, have been exposed to chlorophenate fungicides which are known to be contaminated with polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs). Due to concern about the potential of these workers to have significant body burdens of PCDD/Fs, and the absence of measurements in these workers, a single-compartment pharmacokinetic model was developed to estimate the concentration of PCDD/Fs in the fat tissue of the sawmill workers. Data from a large cohort of B.C. sawmill workers and literature-based data on chlorophenate exposures and PCDD/F concentrations in chlorophenates were used in Monte Carlo simulations to predict a PCDD/F body burden distribution. The median concentrations of HxCDF and HpCDF predicted using the model for the B.C. sawmill worker population exceeded the range measured in unexposed populations. PeCDF and OCDF concentrations exceeded the range measured in unexposed populations at the 70th percentile of the model-predicted distribution, and PeCDD at the 90th percentile. The primary limitation of the model was the scarcity of input data about actual dermal and inhalation exposures to chlorophenates.
authors.affiliation: Occupational Hygiene Program, University of British Columbia, Vancouver, Canada.
authors.forename: C A
authors.initials: CA
authors.lastname: Campbell
authors.forename: K
authors.initials: K
authors.lastname: Teschke
authors.forename: J
authors.initials: J
authors.lastname: Bert
authors.forename: P J
authors.initials: PJ
authors.lastname: Quintana
authors.forename: C
authors.initials: C
authors.lastname: Hertzman
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D001572:Benzofurans / Q000378:metabolism / Q000493:pharmacokinetics*; D001822:Body Burden; D001955:British Columbia; D002140:California; D015331:Cohort Studies; D000072338:Dibenzofurans, Polychlorinated; D004305:Dose-Response Relationship, Drug; D005659:Fungicides, Industrial / Q000378:metabolism / Q000493:pharmacokinetics*; D006207:Half-Life; D006801:Humans; D016273:Occupational Exposure; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics; D012016:Reference Values; D012989:Soil Pollutants / Q000378:metabolism / Q000493:pharmacokinetics*
chemical_list: D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D005659:Fungicides, Industrial; D000072317:Polychlorinated Dibenzodioxins; D012989:Soil Pollutants