title: [Genetic structure and the load of hereditary diseases in five populations of Arkhangel'skaia region].
abstract: A population and medical genetic investigation was performed in a number of raions in the Arkhangel' skaya oblast. Random inbreeding coefficients were 0.000358 and 0.000361 in the Vinogradovskii and Krasnoborskii raions. Malecot's local inbreeding coefficients were 0.000565 and 0.000472, respectively. The endogamy indices were 0.37 and 0.54, respectively. In the urban population, the loads of autosomal dominant, autosomal recessive, and X-linked pathology were 1.01 and 0.98 per 1000 individuals, and 0.29 per 1000 men; in the rural population, they were 1.22, 1.55, and 1.08, respectively. In the populations studied, the hereditary pathology spectrum is described.
authors.forename: R A
authors.initials: RA
authors.lastname: Mamedova
authors.forename: G I
authors.initials: GI
authors.lastname: El'chinova
authors.forename: E A
authors.initials: EA
authors.lastname: Startseva
authors.forename: S I
authors.initials: SI
authors.lastname: Kozlova
authors.forename: A N
authors.initials: AN
authors.lastname: Petrin
authors.forename: G E
authors.initials: GE
authors.lastname: Rudenskaia
authors.forename: O V
authors.initials: OV
authors.lastname: Khlenikova
authors.forename: L K
authors.initials: LK
authors.lastname: Mikhaĭlova
authors.forename: M N
authors.initials: MN
authors.lastname: Efimova
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Shchekotikhina
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Prokhorov
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Kadoshnikova
authors.forename: V A
authors.initials: VA
authors.lastname: Galkina
authors.forename: O V
authors.initials: OV
authors.lastname: Brusintseva
authors.forename: E K
authors.initials: EK
authors.lastname: Ginter
mesh_terms: D003241:Consanguinity; D005260:Female; D005799:Genes, Dominant; D005808:Genes, Recessive; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D008040:Genetic Linkage; D005826:Genetics, Medical; D005828:Genetics, Population; D006801:Humans; D008297:Male; D012423:Rural Health; D012800:Siberia; D014504:Urban Health; D014960:X Chromosome
vernacular_title: Geneticheskaia struktura i gruz nasledstvennykh bolezneĭ v piati populiatsiiakh Arkhangel'skoĭ oblasti.