title: Cotrifazid--an agent against malaria.
abstract: Following the brief information on a new malaria treatment with the fixed multiple combination Cotrifazid (rifampicin+isoniazid+sulfamethoxazole+trimethoprim) in Chemotherapy [1995;41:396-398], very good results are reported for the treatment of 61 patients with various forms of malaria. The tolerance was found to be good. Some relevant fundamental considerations (chemoresistance, synergism/antagonism, fixed multiple combination, switching from monotherapy to combination therapy) and the implementation of the principle of a "multidisease therapy' are discussed.
authors.affiliation: St. Gabriel's Hospital, Namitete, Malawi.
authors.forename: E
authors.initials: E
authors.lastname: Freerksen
authors.forename: E W
authors.initials: EW
authors.lastname: Kanthunkumva
authors.forename: A R
authors.initials: AR
authors.lastname: Kholowa
mesh_terms: D000293:Adolescent; D000328:Adult; D000962:Antimalarials / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D004347:Drug Interactions; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007223:Infant; D007538:Isoniazid / Q000627:therapeutic use*; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D019233:Retreatment; D012293:Rifampin / Q000627:therapeutic use*; D013420:Sulfamethoxazole / Q000627:therapeutic use*; D014195:Travel; D014295:Trimethoprim / Q000627:therapeutic use*
chemical_list: D000962:Antimalarials; D004338:Drug Combinations; C105971:cotrifazid; D014295:Trimethoprim; D013420:Sulfamethoxazole; D007538:Isoniazid; D012293:Rifampin