title: Saccades to moving targets in schizophrenia: evidence for normal posterior cortex functioning.
abstract: People diagnosed with schizophrenia have abnormalities of smooth pursuit eye movement initiation that could be attributable to dysfunction of posterior cortical areas and/or the smooth pursuit regions of frontal cortex. To evaluate whether schizophrenia patients' pursuit initiation performance is most consistent with pre- or postrolandic neuropathology, 25 schizophrenia patients and 25 nonpsychiatric individuals were presented step-ramp stimuli moving either away from or toward the fovea. Schizophrenia and nonpsychiatric individuals did not differ on position error of saccades to moving targets, suggesting that the schizophrenia patients did not have general difficulty with motion perception. During the initial 100 ms of smooth pursuit, however, schizophrenia patients had significantly slower eye velocities than did nonpsychiatric individuals. These results suggest that schizophrenia patients' smooth pursuit abnormalities are not associated with neuropathology of posterior cortical areas.
authors.affiliation: Department of Psychology, University of California-San Diego, La Jolla, USA.
authors.forename: B A
authors.initials: BA
authors.lastname: Clementz
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011698:Pursuit, Smooth / Q000502:physiology*; D012438:Saccades / Q000502:physiology*; D012559:Schizophrenia / Q000503:physiopathology*