Growth factors and cytokines in hair follicle development and cycling: recent insights from animal models and the potentials for clinical therapy.
Hair growth disorders, particularly those that lead to hair loss (alopecia), are common and frequently cause significant mental anguish in affected individuals. The mechanisms underlying the majority of these disorders are unknown. However, insights into the specific molecular mechanisms of hair follicle development and cycling have recently been made using animal models, particularly mice that over- or underexpress a specific gene for a growth factor or cytokine. Other animal models have demonstrated that certain growth factors and cytokines can prevent much of the alopecia caused by cancer chemotherapeutic agents. These animal models have confirmed the importance of growth factors and cytokines in hair follicle development and cycling, and have formed the foundation for potential clinical therapy of hair growth disorders, particularly alopecia. Nevertheless, important questions concerning their efficacy, safety and delivery will need to be answered before successful clinical therapy of any hair growth disorder becomes a reality.
Danilenko
D M
DM
Department of Pathology, Amgen Inc., Thousand Oaks, CA 91320-1789, USA. dimitry.danilenko@amgen.com
Ring
B D
BD
Pierce
G F
GF
D000505:Alopecia / Q000628:therapy*; D000818:Animals; D016207:Cytokines / Q000378:metabolism* / Q000627:therapeutic use; D004195:Disease Models, Animal; D005544:Forecasting; D006133:Growth Substances / Q000378:metabolism* / Q000627:therapeutic use; D018859:Hair Follicle / Q000002:abnormalities*; D006801:Humans; D051379:Mice
D016207:Cytokines; D006133:Growth Substances