title: Mechanical unloading properties of axial flow pumps and their effect on myocardial stunning.
abstract: Postischemic myocardial dysfunction affects morbidity and mortality in patients with coronary artery disease. It is known that mechanical unloading of the left heart ventricle can positively influence postischemic myocardial dysfunction. In this respect we tested two miniaturised axial flow pumps, i.e. the 14-F and the 21-F Hemopump. An experimental study was carried out on 30 open chest sheep where regional myocardial wall motion was followed using sonomicrometry in a preparation of transient coronary artery occlusion. Only the larger 21-F Hemopump showed hemodynamically significant unloading of the left ventricle. Furthermore, as far as stunning is concerned, systolic wall thickening recovered better when this type of pump was used during reperfusion. Also postejection thickening, which is an indication of diastolic postischemic dysfunction, is reduced significantly in the postischemic area (ANOVA, p < 0.05). Thus, the 21F Hemopump, but not the 14F Hemopump, provides adequate mechanical unloading in order to beneficially influence myocardial stunning.
authors.affiliation: Department of Cardiac Surgery, Katholieke Universiteit Leuven, Belgium.
authors.forename: F R
authors.initials: FR
authors.lastname: Waldenberger
authors.forename: B
authors.initials: B
authors.lastname: Meyns
authors.forename: P
authors.initials: P
authors.lastname: Wouters
authors.forename: E
authors.initials: E
authors.lastname: De Ruyter
authors.forename: E
authors.initials: E
authors.lastname: Pongo
authors.forename: W
authors.initials: W
authors.lastname: Flameng
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003327:Coronary Disease / Q000503:physiopathology; D004195:Disease Models, Animal; D006339:Heart Rate / Q000502:physiology*; D006353:Heart-Assist Devices / Q000592:standards*; D017202:Myocardial Ischemia / Q000401:mortality / Q000503:physiopathology*; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology; D017682:Myocardial Stunning / Q000503:physiopathology*; D009206:Myocardium / Q000473:pathology; D012756:Sheep