title: Immunoregulatory circuits and potential treatment of connective tissue diseases.
abstract: Connective tissue diseases are generated by different immunoregulatory alterations. Their better knowledge may lead to new treatment modalities. In systemic lupus erythematosus (SLE), increased IL-10 production by non-T cells might exert an inhibitory effect on Thl CD4+ T cells which would explain the decreased T cell functions observed in these patients. In rheumatoid arthritis (RA) patients, there may be a balance within the synovium, where the local production of IFN-gamma may limit the anti-inflammatory properties of IL- 10, thus leading to chronic damage. This article shows that rational approaches to therapy need to be individualized. In SLE, the potential therapeutic use of monoclonal antibodies to IL-10 seems to be gathering strength, whereas in RA exactly the opposite is contemplated: IL-10 is tried for its potential therapeutic use.
authors.affiliation: Department of Immunology and Rheumatology, Instituto Naciónal de la Nutricion Salvador Zubirán, México.
authors.forename: J
authors.initials: J
authors.lastname: Alcocer-Varela
authors.forename: L
authors.initials: L
authors.lastname: Llorente
authors.forename: D
authors.initials: D
authors.lastname: Alarcón-Segovia
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000628:therapy*; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000628:therapy*
chemical_list: D000911:Antibodies, Monoclonal; D016207:Cytokines