title: [A quantitative study of the presence of interleukin-1 and interleukin-6 in cholesteatoma of the middle ear].
abstract: Cholesteatoma of the middle ear is an inflammatory disease characterized by the presence of a keratinized squamous layer that leads to bone destruction. The process may be mediated by various factors (interleukins) produced by an activated macrophages and keratinocytes. Interleukin-1 (IL-1) and interleukin-6 (IL-6) concentrations were measured in extracts of cholesteatoma and normal tissue using the enzyme immunoassay technique (ELISA) after protein concentrations were determined. IL-1 alpha and IL-6 had higher concentrations in cholesteatoma than in normal skin and played a prominent role in bone resorption.
authors.affiliation: Hospital General Universitario Reina Sofia, Córdoba.
authors.forename: P O
authors.initials: PO
authors.lastname: Aumente
authors.forename: J
authors.initials: J
authors.lastname: Bujía
authors.forename: C
authors.initials: C
authors.lastname: Kim
authors.forename: J
authors.initials: J
authors.lastname: Jiménez Giménez
authors.forename: P
authors.initials: P
authors.lastname: López Villarejo
mesh_terms: D001862:Bone Resorption / Q000150:complications / Q000503:physiopathology; D002781:Cholesteatoma / Q000150:complications / Q000503:physiopathology*; D046508:Culture Techniques; D004432:Ear, Middle / Q000503:physiopathology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis*; D015850:Interleukin-6 / Q000032:analysis*; D015603:Keratinocytes; D012867:Skin / Q000737:chemistry; D013701:Temporal Bone / Q000503:physiopathology
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6
vernacular_title: Estudio cuantitativo de la presencia de interleucina-1 e interleucina-6 en el colesteatoma de oído medio.