Autologous peripheral blood stem cell transplantation in a patient with previous invasive middle ear mucormycosis.
A 52-year-old male diagnosed with acute myeloid leukemia (AML) developed an invasive middle-ear mucormycosis during the neutropenic period after consolidation chemotherapy which resolved successfully with surgery and antifungal therapy. The patient underwent autologous peripheral blood stem cell transplantation (APBSCT) in first complete remission with antifungal prophylaxis with liposomal amphotericin B (AmB). There was no clinical, radiological or microbiological data of mycotic reactivation. This is the first reported stem cell transplantation (SCT) in a patient with prior invasive mucormycosis.
Olalla
I
I
Department of Hematology, Marqués de Valdecilla University Hospital, Faculty of Medicine, University of Cantabria, Santander, Spain.
Ortín
M
M
Hermida
G
G
Cortés
M A
MA
Richard
C
C
Iriondo
A
A
Mozota
M L
ML
Zubizarreta
A
A
D000208:Acute Disease; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects; D005158:Facial Paralysis / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage / Q000009:adverse effects; D007951:Leukemia, Myeloid / Q000150:complications; D008297:Male; D008416:Mastoid / Q000601:surgery; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage / Q000009:adverse effects; D009091:Mucormycosis / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D009225:Myringoplasty; D009503:Neutropenia / Q000139:chemically induced / Q000150:complications / Q000628:therapy*; D010035:Otitis Media, Suppurative / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D012074:Remission Induction; D019172:Transplantation Conditioning; D014182:Transplantation, Autologous
D000935:Antifungal Agents; D003561:Cytarabine; D000666:Amphotericin B; D008942:Mitoxantrone; D015255:Idarubicin