Second primary lung cancer in Flanders: frequency, clinical presentation, treatment and prognosis.
Patient and tumour characteristics of 23 patients presenting with a second primary lung cancer were analysed and compared with 534 patients with radically resected stage 1 non-small cell lung cancer (NSCLC). None of these characteristics is associated with a higher occurrence rate for second primary lung cancer. Prognosis in the latter patients is significantly worse than after resection of a 'solitary' NSCLC: the median survival time (MST) after resection of the first tumour is 50 months; after diagnosis of the second tumour only 14 months. Surgically retreated patients have a prognosis that is similar to that after resection of a 'solitary' NSCLC. No separate independent prognostic factors responsible for this survival difference could be isolated. Squamous histology and central location are associated with a longer recurrence free survival time. We conclude that the occurrence of a second primary lung cancer can not be predicted based on patient or tumour characteristics and that only surgical retreatment offers a chance of long survival in these patients.
Van Meerbeeck
J
J
Task Group on Lung Cancer-VRGT, Brussels, Belgium.
Weyler
J
J
Thibaut
A
A
Vansteenkiste
J
J
Aumann
J
J
Deneffe
G
G
Galdermans
D
D
Haelterman
M
M
Joos
G
G
Noppen
M
M
Pinson
P
P
Tasson
J
J
van den Eeckhout
A
A
Uydebrouck
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001530:Belgium / Q000453:epidemiology; D001706:Biopsy; D002289:Carcinoma, Non-Small-Cell Lung / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D011446:Prospective Studies; D012008:Recurrence; D015996:Survival Rate