[Preliminary results of the induction treatment in cases of NSCLC (stage III A and B)].
Up to 1994, we surgically treated for lung cancer, 1222 patients, selected from a total of 3157 observed cases. N.S.C.L.C. were 2891 and 899 of these were resected. Some neoadjuvant therapy has been applied in recent years to 170 patients: 83 of these were treated with CT (cisplatin, epirubicin and VP-16, in two cycles with a three week interval) and 41 had RT (30 Gy in daily fractions of 2); 16 patients had the two treatments in sequence. Radiation was mainly used for T problems, chemotherapy for management of N2; the sequence has so far been applied in selected cases. There have been 73 thoracotomies after a successful neoadjuvant, that is in more than 52% of the re-evaluated patients. Resection was possible in 32 of the RT-prepared patients, in 21 of the CT-prepared and in 8 who completed the double treatment: that means a resection was possible in 47% of cases. Because of the recent introduction of neoadjuvant therapy, late survival cannot be evaluated at present.
Beltrami
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Istituto di Clinica Chirurgica dell Università di Chieti.
D002283:Carcinoma, Bronchogenic / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D012074:Remission Induction
Primi risultati di trattamenti induttivi nei casi di NSCLC (stadi III A e B).