Esters of cephalosporins. Part III. Separation and properties of the R and S isomers of the 1-acetoxyethyl ester of cefuroxime.
Two separation methods for the R and S isomers of the 1-acetoxyethyl ester of cefuroxime [I] were evaluated. Physico-chemical and biological properties of these isomers were studied. It was found that the R isomer after oral administration to rats is absorbed better and faster than the isomer S.
Oszczapowicz
I
I
Department of Modified Antibiotics, Institute of Biotechnology and Antibiotics, Warsaw, Poland.
Małafiej
E
E
Horoszewicz-Małafiej
A
A
Szelachowska
M
M
Kuklewicz
C
C
Sierańska
E
E
D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002444:Cefuroxime / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000494:pharmacology; D002511:Cephalosporins / Q000302:isolation & purification* / Q000493:pharmacokinetics* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D006207:Half-Life; D008826:Microbial Sensitivity Tests; D011355:Prodrugs / Q000302:isolation & purification* / Q000493:pharmacokinetics* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013211:Staphylococcus aureus / Q000187:drug effects; D013237:Stereoisomerism
D002511:Cephalosporins; D011355:Prodrugs; D002444:Cefuroxime; C040738:cefuroxime axetil