The neutron therapy clinical programme at the National Accelerator Centre (NAC).
A total of 721 patients were treated in the neutron therapy programme at NAC from February 1989-March 1995 with a p(66)/Be isocentric unit. The preliminary results showed: 3-year local control and survival probabilities of 57 and 79% respectively for advanced salivary gland tumours; increased local control for twice-daily neutron therapy for advanced head and neck cancer compared with photon therapy; local control rates of 68 and 83% for locally advanced breast cancer treated with 17 and 19 Gy respectively; complete response rates of 67% for macroscopic residual soft tissue sarcomas and those with irresectable disease of less than 10 cm; complete response rate of 56% for macroscopic residual uterine sarcoma with a median follow up of 38 months; 2-year local control rate and survival of 44 and 38% respectively for advanced squamous carcinoma of the maxillary antrum; complete response rate of 38% for advanced osteosarcomas and chondrosarcomas.
Stannard
C E
CE
Department of Radiation Oncology, University of Cape Town, South Africa.
Vernimmen
F J
FJ
Jones
D T
DT
Van Wijk
A L
AL
Brennan
S M
SM
Visser
A M
AM
Johnson
C A
CA
Wilson
J A
JA
Murray
E A
EA
Levin
C V
CV
Mills
E E
EE
Alberts
A
A
Werner
I D
ID
Smit
B J
BJ
Schmitt
G
G
D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy; D018567:Breast Neoplasms, Male / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D009369:Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D009502:Neutrons; D016730:Program Development; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy / Q000379:methods*; D012509:Sarcoma / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy; D016019:Survival Analysis; D014594:Uterine Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy