An analysis of DTP-associated reactions by manufacturer, batch, vaccinator, series number and infant weight.
OBJECTIVE
To determine whether two commonly used DTP batches manufactured by Rhöne-Poulenc Rorer were more reactogenic than two commonly used batches manufactured by the South African Institute of Medical Research.


METHODS
Prospective study.


METHODS
Six community clinics.


METHODS
Infants routinely scheduled for their first three DTP immunisations.


METHODS
Local and systemic adverse reactions following immunisation with DTP.


RESULTS
Local reactions were significantly more common with both Rhöne-Poulenc Rorer products.


CONCLUSIONS
All adverse reaction rates compared favourably with those reported by the Centers for Disease Control.
Benadé
J G
JG
Department of Community Health, University of Stellenbosch, Tygerberg, W. Cape.
D001835:Body Weight; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004345:Drug Industry; D004348:Drug Labeling; D006801:Humans; D007223:Infant; D007273:Injections, Intramuscular; D011446:Prospective Studies; D013019:South Africa; D014611:Vaccination / Q000379:methods; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000009:adverse effects
D015721:Diphtheria-Tetanus-Pertussis Vaccine; D017778:Vaccines, Combined