title: Intravenous midazolam as a sedative for colonoscopy: a randomized, double-blind clinical trial.
abstract: METHODS
  Forty patients, aged between 36 and 60 years, scheduled to undergo colonoscopic removal of colorectal polyps were randomly assigned to receive 0.9% saline solution (n = 20) or 0.05 mg/kg body weight of midazolam (n = 20) intravenously.
  
  
  RESULTS
  Midazolam significantly (P < 0.001) increased the tolerance of patients to colonoscopy. It had no significant effect on pulse or systolic blood pressure during endoscopy. Arterial oxygen saturation decreased significantly (P < 0.01) during endoscopy in patients pre-treated with midazolam, but it did not decrease by more than 5%.
  
  
  CONCLUSIONS
  Intravenous midazolam is useful as a sedative for colonoscopy, but we recommend continuous oxygen saturation monitoring during endoscopy.
authors.affiliation: Department of Nursing, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yuno
authors.forename: H
authors.initials: H
authors.lastname: Iishi
authors.forename: M
authors.initials: M
authors.lastname: Tatsuta
authors.forename: K
authors.initials: K
authors.lastname: Hifumi
authors.forename: M
authors.initials: M
authors.lastname: Omori
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003111:Colonic Polyps / Q000601:surgery; D003113:Colonoscopy / Q000379:methods; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D007275:Injections, Intravenous; D008297:Male; D008874:Midazolam / Q000627:therapeutic use*; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010919:Placebos; D011674:Pulse / Q000187:drug effects
chemical_list: D006993:Hypnotics and Sedatives; D010919:Placebos; D008874:Midazolam; D010100:Oxygen