title: [Predictive factors of induction of ventricular arrhythmia under amiodarone].
abstract: A good result of electrophysiological investigations under amiodarone therapy distinguishes a low risk group of patients with malignant ventricular arrhythmias. The authors set out to determine the factors predictive of this response in order to identify patients better protected by amiodarone at an earlier stage. Fourty-five patients with an average age of 56 years, were referred for evaluation of severe ventricular arrhythmias, monomorphic ventricular tachycardia being inducible during electrophysiological investigation in all cases before treatment. Amiodarone was prescribed orally at degressive doses. A control electrophysiological study was performed 4 to 6 weeks later. Eighteen patients (40%) were considered to be responders (absence of inducible ventricular arrhythmia or inducible non-sustained tachycardia or tachycardia with a cycle length increased by over 100 ms with respect to the base-line study). The other 27 patients were considered to be non-responders. No clinical or paraclinical parameter was found to distinguish responders from non-responders. The authors conclude that the data obtained before control electrophysiological investigation under amiodarone does not allow prediction of the response to this drug. The search for early prognosis of the efficacy of amiodarone in preventing ventricular arrhythmias therefore requires electrophysiological investigation after impregnation.
authors.affiliation: Hôpital cardiovasculaire et pneumologique Louis-Pradel, Lyon-Montchat.
authors.forename: N
authors.initials: N
authors.lastname: Bourret
authors.forename: G
authors.initials: G
authors.lastname: Kirkorian
authors.forename: P
authors.initials: P
authors.lastname: Chevalier
authors.forename: C
authors.initials: C
authors.lastname: Bellon
authors.forename: C
authors.initials: C
authors.lastname: Richalet
authors.forename: D
authors.initials: D
authors.lastname: Bouchayer
authors.forename: E
authors.initials: E
authors.lastname: Bonnefoy
authors.forename: P
authors.initials: P
authors.lastname: Touboul
mesh_terms: D000328:Adult; D000368:Aged; D000638:Amiodarone / Q000627:therapeutic use*; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D002304:Cardiac Pacing, Artificial; D016757:Death, Sudden, Cardiac / Q000453:epidemiology; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010347:Patient Care Planning; D011237:Predictive Value of Tests; D012008:Recurrence; D012189:Retrospective Studies; D017180:Tachycardia, Ventricular / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D016896:Treatment Outcome; D014693:Ventricular Fibrillation / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology
chemical_list: D000889:Anti-Arrhythmia Agents; D000638:Amiodarone
vernacular_title: Facteurs prédictifs du déclenchement d'une arythmie ventriculaire sous amiodarone.