title: [Proteases and their inhibitors in posttraumatic knee joint effusion].
abstract: Humoral aspects are being discussed in development of arthrosis. Punctuate of 144 traumatized knee joints has been investigated. Proteolytic enzymes elastase and cathepsin D were assessed. Furthermore, protease inhibitors alpha 1-antitrypsin and alpha 2-macroglobulin were determined. Activity of chondrolytic enzymes elastase and cathepsin D clearly correlates with the clinical severity of injuries. At the same time, primary inhibitory mechanisms for compensation seem to be non-sufficient, however.
authors.affiliation: Chirurgische Universitätsklinik und-Poliklinik Würzburg.
authors.forename: E
authors.initials: E
authors.lastname: Kunz
authors.forename: T R
authors.initials: TR
authors.lastname: Blattert
authors.forename: A
authors.initials: A
authors.lastname: Weckbach
mesh_terms: D002402:Cathepsin D / Q000032:analysis; D015331:Cohort Studies; D005122:Exudates and Transudates / Q000201:enzymology; D006801:Humans; D007718:Knee Injuries / Q000378:metabolism*; D010196:Pancreatic Elastase / Q000032:analysis; D010447:Peptide Hydrolases / Q000032:analysis*; D011480:Protease Inhibitors / Q000032:analysis*; D013582:Synovial Fluid / Q000201:enzymology*; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis
chemical_list: D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D010447:Peptide Hydrolases; D010196:Pancreatic Elastase; D002402:Cathepsin D
vernacular_title: Proteasen und deren Inhibitoren im posttraumatischen Kniegelenkserguss.