Late reversibility of chronic ifosfamide-associated nephrotoxicity in a child.
Although reversibility of acute ifosfamide-induced nephrotoxicity is well documented, there is a paucity of data concerning the long-term outcome of chronic renal toxicity, and full recovery from established damage has not been reported. A 4-year-old boy presented with hypophosphatemic rickets 9 months after completion of combination chemotherapy (including ifosfamide) for prostatic rhabdomyosarcoma. Further investigation confirmed glomerular and generalised tubular dysfunction with a Fanconi syndrome. However, serial investigation over the next 4 years revealed complete and sustained recovery of this chronic nephrotoxicity.
Ashraf
M S
MS
Sir James Spence Institute of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne, England.
Skinner
R
R
English
M W
MW
Craft
A W
AW
Pearson
A D
AD
D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects* / Q000627:therapeutic use; D002675:Child, Preschool; D002908:Chronic Disease; D005198:Fanconi Syndrome / Q000139:chemically induced; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D017674:Hypophosphatemia / Q000139:chemically induced; D007069:Ifosfamide / Q000009:adverse effects* / Q000627:therapeutic use; D007668:Kidney / Q000187:drug effects*; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy; D012208:Rhabdomyosarcoma / Q000188:drug therapy
D018906:Antineoplastic Agents, Alkylating; D007069:Ifosfamide