title: Vulvoperineal reconstruction after excision of anogenital multifocal intraepithelial neoplasia ("MIN").
abstract: Over the past 7 years, 12 women have been treated utilising a radical surgical approach for extensive vulval involvement as a component of multifocal intraepithelial neoplasia (MIN) of the female genital tract. The patients were analysed with respect to the anatomical site of involvement, age, presenting complaints and their duration, colposcopic examination, histopathology and surgical treatment. Gynaecologists, general surgeons and plastic surgeons were involved in the surgical treatment which was an initial colostomy followed by a definitive vulvoperineal resection and simultaneous vulval reconstruction using meshed split skin grafts or a combination of skin grafts and local flaps. 17 vulvoperineal reconstructions were done for 12 patients. Three had an incomplete histopathological clearance at the initial operation. Apart from these three patients, one had recurrence of symptoms alone, without any evidence of MIN, which was possibly due to human papilloma virus infection. One patient developed malignant squamous invasion 4 years later, which was cured with surgical excision and reconstruction. Colostomy closure was done after achieving local control of the disease. This staged approach does achieve the objectives of eliminating disease and alleviating symptoms. It preserves function and attempts to reconstruct normal anatomy without compromising the principles of surgical oncology and results in a high patient satisfaction.
authors.affiliation: Queen Elizabeth Medical Centre, UK.
authors.forename: S S
authors.initials: SS
authors.lastname: Thomas
authors.forename: R
authors.initials: R
authors.lastname: Chenoy
authors.forename: J W
authors.initials: JW
authors.lastname: Fielding
authors.forename: T P
authors.initials: TP
authors.lastname: Rollason
authors.forename: J A
authors.initials: JA
authors.lastname: Jordan
authors.forename: A
authors.initials: A
authors.lastname: Bracka
mesh_terms: D000328:Adult; D001005:Anus Neoplasms / Q000473:pathology / Q000601:surgery*; D002278:Carcinoma in Situ / Q000473:pathology / Q000601:surgery*; D003125:Colostomy; D005260:Female; D005500:Follow-Up Studies; D005833:Genital Neoplasms, Female / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D010502:Perineum / Q000601:surgery*; D011446:Prospective Studies; D016038:Skin Transplantation; D013524:Surgical Flaps / Q000379:methods; D014844:Vulva / Q000601:surgery*