title: Establishing tolerable dungeness crab (Cancer magister) and razor clam (Siliqua patula) domoic acid contaminant levels.
abstract: Domoic acid has been found in razor clams (Siliqua patula) and dungeness crabs (Cancer magister) in Washington State and elsewhere on the West Coast of the United States. Due to toxic effects associated with domoic acid exposure, an effort has been made to establish tolerable domoic acid levels in crabs and clams obtained from commercial harvest and sale and from individual recreational harvesting. To accomplish this, the amount of clams and crabs consumed by populations of concern was determined, a tolerable daily intake (TDI) was developed for individuals most sensitive to effects of this compound, and the TDI was equated with consumption patterns to determine tolerable clam and crab domoic acid levels. Results indicate that the primary health effects associated with domoic acid toxicity can be averted in populations of concern and for others consuming crabs or clams less frequently (or in lesser quantity) if domoic acid contaminant concentration does not exceed 30 mg/kg in the hepatopancreas and viscera of dungeness crabs or 20 mg/kg in clams.
authors.affiliation: Washington State Department of Health, Olympia 98504, USA.
authors.forename: K
authors.initials: K
authors.lastname: Mariën
mesh_terms: D000818:Animals; D049872:Bivalvia / Q000737:chemistry*; D003386:Brachyura / Q000737:chemistry*; D005506:Food Contamination / Q000032:analysis*; D005517:Foodborne Diseases / Q000517:prevention & control; D006801:Humans; D007608:Kainic Acid / Q000031:analogs & derivatives* / Q000032:analysis / Q000506:poisoning; D008387:Marine Toxins / Q000032:analysis* / Q000506:poisoning; D009498:Neurotoxins / Q000032:analysis* / Q000506:poisoning; D019055:No-Observed-Adverse-Effect Level; D018570:Risk Assessment; D014861:Washington
chemical_list: D008387:Marine Toxins; D009498:Neurotoxins; C012301:domoic acid; D007608:Kainic Acid