title: Inhibitory effect of MK-801 on amantadine-induced dopamine release in the rat striatum.
abstract: In the present study, we examined the effect of amantadine on extracellular dopamine levels in the rat striatum using an in vivo microdialysis. Perfusion of amantadine (0.1-1 mM) through the microdialysis probe caused an increase both in extracellular dopamine and glutamate levels in rat striatum. Amantadine was found to increase extracellular dopamine concentration in Ca(2+)-dependent manner, but the effect was not abolished by omega-conotoxin. Although intraperitoneal administration of MK-801 [(+)-5-methyl-10, 11-dihydroxy-5H-dibenzo (a,d)cyclohepten-5,10-imine] alone could not significantly alter the concentration of dopamine, it attenuated amantadine-induced increase in dopamine level. These findings suggest that an interaction between dopaminergic and glutamatergic neurotransmission is an important component in the regulation of striatal dopamine levels.
authors.affiliation: Third Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Yamashita
authors.forename: Y X
authors.initials: YX
authors.lastname: Zhang
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
mesh_terms: D000547:Amantadine / Q000494:pharmacology*; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D016291:Dizocilpine Maleate; D000547:Amantadine; D004298:Dopamine