Localization of Cu/Zn-SOD and Mn-SOD in the rat cochlea.
Distributions of the copper/zinc-superoxide dismutase (Cu/Zn-SOD) and the manganese superoxide dismutase (Mn-SOD) in the rat cochlea were studied by immunohistochemistry with specific polyclonal antibodies to Mn-SOD and Cu/Zn-SOD. Coexpression of Mn-SOD and Cu/Zn-SOD was observed in the cochlear tissues with differing immunoactivity intensities. The presence of Cu/Zn- and Mn-SOD implies the existence of a defense system against free oxygen radical (FOR) injury in cochlear tissues.
Rarey
K E
KE
Department of Anatomy & Cell Biology, College of Medicine, University of Florida, Gainesville 32610, USA.
Yao
X
X
D000818:Animals; D003051:Cochlea / Q000378:metabolism / Q000648:ultrastructure*; D005609:Free Radicals; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism / Q000648:ultrastructure*
D005609:Free Radicals; D013482:Superoxide Dismutase