Determinants for coronary heart disease in non-insulin-dependent diabetes mellitus: lessons from the diabetes intervention study.
In NIDDM a clustering of established coronary risk factors, e.g. the metabolic syndrome is responsible for excessive incidence of myocardial infarction. The harmful effects of these risk factors are aggravated by poor glucose control. Hyperinsulinaemia is associated with a higher level of risk factors for coronary heart disease. Individuals with subsequent myocardial infarction exhibit higher levels of serum insulin at entry. However, insulin in multivariate analysis was no independent risk factor. Perfect control of blood glucose, triglycerides and blood pressure was associated with a lower incidence of coronary heart disease. By extrapolation an integrated approach to correct the anomalies of the metabolic syndrome seems to be necessary to prevent macroangiopathy and improve life expectancy.
Hanefeld
M
M
Department of Clinical Metabolic Research, Medical Faculty, Technical University Dresden, Germany.
Schmechel
H
H
Julius
U
U
Schwanebeck
U
U
D002986:Clinical Trials as Topic; D003327:Coronary Disease; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D006801:Humans; D007328:Insulin / Q000097:blood; D015337:Multicenter Studies as Topic; D009203:Myocardial Infarction; D012307:Risk Factors
D007328:Insulin