The chemical composition of tooth enamel in recessive dystrophic epidermolysis bullosa: significance with respect to dental caries.
Previous reports have linked the prevalence of tooth abnormalities with high caries experience in the different types of epidermolysis bullosa (EB). However, it is not known to what extent the apparent susceptibility to enamel caries is due to disease-related altered enamel chemistry in these cases. The aim of this study was to characterize the enamel of teeth from patients suffering from recessive epidermolysis bullosa dystrophica (rEBD) in terms of its mineral content, carbonate content, protein content, and amino acid composition. The results showed that dental enamel from these patients was essentially normal in terms of its chemistry. It is therefore concluded that the high caries experience in recessive dystrophic epidermolysis bullosa patients is probably related to other factors, such as compromised oral hygiene and prolonged oral clearance due to extensive oral soft tissue damage and a cariogenic diet.
Kirkham
J
J
Division of Oral Biology, Leeds Dental Institute, UK.
Robinson
C
C
Strafford
S M
SM
Shore
R C
RC
Bonass
W A
WA
Brookes
S J
SJ
Wright
J T
JT
D000596:Amino Acids / Q000032:analysis; D015153:Blotting, Western / Q000379:methods; D002648:Child; D003731:Dental Caries / Q000209:etiology / Q000378:metabolism*; D003743:Dental Enamel / Q000737:chemistry*; D003746:Dental Enamel Proteins / Q000032:analysis; D004198:Disease Susceptibility; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods; D016108:Epidermolysis Bullosa Dystrophica / Q000150:complications / Q000378:metabolism*; D006801:Humans; D014131:Trace Elements / Q000032:analysis
D000596:Amino Acids; D003746:Dental Enamel Proteins; D014131:Trace Elements