Histochemistry of the human hair follicle.
Immunohistochemistry of the human hair follicle is of increasing interest in hair research. The data on antigen distribution in the different epithelial and mesenchymal structures of this unique skin appendage are superfluous now. In the present chapter, I will concentrate on selected aspects related to hair follicle differentiation, epithelial-mesenchymal interactions, proliferation and metabolic activity. Hair diseases are common. Not unusually, hair growth and structure reflect systemic disturbances. Basic knowledge of hair anatomy and histochemistry is required for their rational evaluation. Immunohistochemistry is a valuable tool for microanatomy of the hair apparatus. It offers a link between the biochemical data and structural components of hair follicles, which may help to better understand physiology of hair growth and hair diseases.
Wollina
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Department of Dermatology, Friedrich Schiller University Jena, Germany.
D000941:Antigens / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism; D002454:Cell Differentiation; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D000091344:Filaggrin Proteins; D006023:Glycoproteins / Q000378:metabolism; D006197:Hair / Q000254:growth & development; D018859:Hair Follicle / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000378:metabolism; D037102:Lectins / Q000378:metabolism; D018862:Merkel Cells / Q000166:cytology / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism; D009479:Neuropeptides / Q000378:metabolism; D021382:Protein Sorting Signals / Q000378:metabolism; D017978:Receptors, Growth Factor / Q000378:metabolism
D000941:Antigens; D002135:Calcium-Binding Proteins; D016326:Extracellular Matrix Proteins; D000091344:Filaggrin Proteins; D006023:Glycoproteins; D007381:Intermediate Filament Proteins; D037102:Lectins; D009363:Neoplasm Proteins; D009479:Neuropeptides; D021382:Protein Sorting Signals; D017978:Receptors, Growth Factor