A review of nonparametric tests for changepoint problems, with application to a recombinant drug therapy clinical trial.
We review general classes of nonparametric tests for the changepoint problem. We extend these tests to analyze the results of a clinical trial examining whether pretreatment of surgical patients with erythropoietin reduces their subsequent need for blood transfusions. We find a changepoint in baseline hemoglobin levels, below which pretreatment with erythropoietin appears particularly beneficial relative to placebo.
Koziol
J A
JA
Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037, USA.
Wu
S C
SC
D004311:Double-Blind Method; D004358:Drug Therapy / Q000379:methods; D004921:Erythropoietin / Q000627:therapeutic use; D006454:Hemoglobins / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008432:Mathematical Computing; D016032:Randomized Controlled Trials as Topic; D011994:Recombinant Proteins / Q000627:therapeutic use; D013223:Statistics as Topic / Q000379:methods*
D006454:Hemoglobins; D011994:Recombinant Proteins; D004921:Erythropoietin