[Metabolic changes in arachidonic acid during aspirin desensitization].
Aspirin sensitivity occurs in 10% of all asthmatics patients. In this subset of asthmatics, nasal congestion and bronchospasm occurs between 30-180 minutes after ingestion of aspirin. Following a respiratory reaction to aspirin, all patients can be desensitized to aspirin by repetitively introducing small and then larger doses of aspirin until the asthmatic subject can ingest 650 mg of aspirin without adverse effect. The mechanism of aspirin sensitivity are incompletely understood. And the reasons why ASA desensitization occurs universally are unknown. In this study, known ASA sensitive and control insensitive asthmatics were challenged with ASA. Urine was collected before, during induced bronchospasm, and after ingestion of 650 mg of ASA when the adverse effect (ie., acute desensitization) had subsided. Excretion levels of cyclo-oxygenase and lipoxygenase products in the urine were determined.
Salazar Villa
R M
RM
Universidad de Guadalajara, México.
Zambrano Villa
S
S
D000082:Acetaminophen / Q000009:adverse effects; D000328:Adult; D000368:Aged; D016718:Arachidonic Acid / Q000378:metabolism*; D001241:Aspirin / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D001249:Asthma / Q000139:chemically induced* / Q000628:therapy / Q000652:urine; D001711:Biotransformation; D001986:Bronchial Spasm / Q000139:chemically induced / Q000652:urine; D003404:Creatinine / Q000097:blood; D003429:Cross Reactions; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000628:therapy / Q000652:urine; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000009:adverse effects; D017999:Leukotriene E4 / Q000652:urine*; D015289:Leukotrienes / Q000096:biosynthesis; D008084:Lipoxygenase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018448:Models, Immunological; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D013447:Sulfites / Q000009:adverse effects; D013929:Thromboxane B2 / Q000652:urine*
D016861:Cyclooxygenase Inhibitors; D015289:Leukotrienes; D013447:Sulfites; D016718:Arachidonic Acid; D000082:Acetaminophen; D013929:Thromboxane B2; D017999:Leukotriene E4; D003404:Creatinine; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases; D001241:Aspirin; D006854:Hydrocortisone
Cambios metabólicos del ácido araquidónico en la desensibilización a la aspirina.