Vitrectomy and systemic fluconazole for treatment of endogenous fungal endophthalmitis.
OBJECTIVE
To investigate the efficacy of pars plana vitrectomy and oral fluconazole without injection of intravitreal antimycotic agents in the treatment of vitritis resulting from Candida endophthalmitis.


METHODS
Six eyes of five patients with suspected Candida endophthalmitis were treated with pars plana vitrectomy and systemic fluconazole for at least 3 weeks. Patients were observed postoperatively for at least 4 months.


RESULTS
Clinical signs of infection cleared and visual acuity improved postoperatively in all six cases. One recurrent case was attributed to a retained indwelling venous catheter.


CONCLUSIONS
Treatment of advanced endogenous Candida endophthalmitis with vitrectomy and systemic fluconazole offers an effective alternative to management with intravitreal amphotericin B in selected cases.
Christmas
N J
NJ
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, FL 33101, USA.
Smiddy
W E
WE
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002177:Candidiasis / Q000209:etiology / Q000628:therapy*; D003131:Combined Modality Therapy; D009877:Endophthalmitis / Q000382:microbiology / Q000628:therapy*; D015821:Eye Infections, Fungal / Q000209:etiology / Q000628:therapy*; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012008:Recurrence; D014792:Visual Acuity; D014821:Vitrectomy / Q000379:methods*
D000935:Antifungal Agents; D015725:Fluconazole