[Effectiveness of virus-specific proteins in immunogenesis during experimental Marburg fever].
The protective properties of early virus-specific proteins (EVSP) of Marburg virus have been studied. Immunoglobulins to EVSP in combination with immunoglobulins to UV-inactivated Marburg virus prevented lethal infection in Marburg virus infected guinea pigs. More than 80% of guinea pigs immunized by mixture of EVSP and UV-inactivated Marburg virus survived after challenge with 25 LD50 of Marburg virus. The explanation of this phenomenon and its further utilization are discussed.
Donchenko
V V
VV
Lebedev
V N
VN
Markin
V A
VA
Firsova
I V
IV
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D006168:Guinea Pigs; D017874:Immediate-Early Proteins / Q000276:immunology*; D008379:Marburg Virus Disease / Q000276:immunology* / Q000517:prevention & control; D029024:Marburgvirus / Q000276:immunology*; D051379:Mice; D014611:Vaccination
D000914:Antibodies, Viral; D017874:Immediate-Early Proteins
Effektivnost' virusspetsificheskikh belkov v immunogeneze pri éksperimental'noĭ likhoradke Marburg.