[Role of type II secreted phospholipase A2 in inflammatory processes].
Secreted phospholipase A2 has been detected in numerous inflammatory and infectious diseases. Since the cloning of the type II sPLA2 in 1989 from rheumatoid arthritis synovial fluid, a direct or indirect participation of type II sPLA2 in the production of lipid mediators has been purposed. This paper reviews the different studies from the literature alleging that type II sPLA2 participates to inflammatory processes and lipid mediators synthesis.
Jacques
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C
URA CNRS 1283, Faculté de Médecine Saint-Antoine, Paris, France.
Berenbaum
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F
D000818:Animals; D006801:Humans; D066298:In Vitro Techniques; D007249:Inflammation / Q000201:enzymology*; D050356:Lipid Metabolism; D051379:Mice; D010741:Phospholipases A / Q000235:genetics / Q000378:metabolism*; D054467:Phospholipases A2
D010741:Phospholipases A; D054467:Phospholipases A2
Place de la phospholipase A2 sécrétée de type II dans la réaction inflammatoire.