title: [Myogenic hyperuricemia].
abstract: Myogenic hyperuricemia is caused by over-production of uric acid, which based on the excessive degradation of purine derivatives in exercising muscle. This phenomenon is frequently observed in the patients of muscle glycogen storage disease (GSD) types III, V and VII. In these patients, impairment of muscle ATP production leads to over-production of AMP, followed by excessive release of inosine and hypoxanthine from the muscle. The molecular lesions of muscle GSDs have been well analyzed. Recent repertoire of these mutations were referred in respect of myogenic hyperuricemia.
authors.affiliation: Second Department of Internal Medicine, Osaka University Medical School.
authors.forename: T
authors.initials: T
authors.lastname: Yamasaki
authors.forename: T
authors.initials: T
authors.lastname: Hamaguchi
authors.forename: H
authors.initials: H
authors.lastname: Nakajima
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuzawa
mesh_terms: D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D004734:Energy Metabolism; D006008:Glycogen Storage Disease / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D019271:Hypoxanthine / Q000378:metabolism; D009132:Muscles / Q000378:metabolism*; D009154:Mutation; D011687:Purines / Q000378:metabolism; D014527:Uric Acid / Q000097:blood*
chemical_list: D011687:Purines; D014527:Uric Acid; D019271:Hypoxanthine; D000249:Adenosine Monophosphate; D000255:Adenosine Triphosphate; C030985:purine