Studies on the mechanism of hydralazine induced mutagenicity and genotoxicity.
The mutagenicity (Ames test) and genotoxicity (SOS Chromotest) of hydralazine were studied. Hydralazine was found to be genotoxic to E.coli PQ37. In experiments with E.coli MD332 it was genotoxic in responsive temperature (30 degrees C) but not genotoxic in non-responsive temperature (42 degrees C). Hydralazine was mutagenic to S.typhimurium TA100 and TA104 but not mutagenic to TA102. Different active oxygen species scavengers did not influence the genotoxicity and mutagenicity of hydralazine.
Chopkiewicz
B
B
Drug Institute, Warsaw, Poland.
Ejchart
A
A
Marczewska
J
J
D000959:Antihypertensive Agents / Q000633:toxicity*; D004347:Drug Interactions; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D016166:Free Radical Scavengers / Q000494:pharmacology; D006830:Hydralazine / Q000633:toxicity*; D009152:Mutagenicity Tests; D013014:SOS Response, Genetics; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013696:Temperature
D000959:Antihypertensive Agents; D016166:Free Radical Scavengers; D006830:Hydralazine