The lack of dopaminergic effects on the motor responses produced by magnetic cortical stimulation in patients with Parkinson's disease.
The effects of levo-dopa administration on the responses in the abductor pollicis brevis muscle after magnetic cortical stimulation, and on the auditory effects on the motor responses produced by magnetic cortical stimulation, were examined in eight patients with Parkinson's disease (PD). Levo-dopa administration did not change the amplitudes of the motor responses or the auditory effects on the motor responses produced by magnetic cortical stimulation. Not only the dopaminergic system, but also other neurotransmitter systems, may play a role in the motor disturbance of PD patients, at least advanced PD patients.
Nakashima
K
K
Division of Neurology, Faculty of Medicine, Tottori University, Yonago, Japan.
Wang
Y
Y
Shimoda
M
M
Sakuma
K
K
Takahashi
K
K
D004298:Dopamine / Q000502:physiology*; D004558:Electric Stimulation; D006801:Humans; D007980:Levodopa / Q000494:pharmacology* / Q000627:therapeutic use; D008280:Magnetics; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology*; D018482:Muscle, Skeletal / Q000187:drug effects / Q000503:physiopathology; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology*; D010775:Photic Stimulation
D007980:Levodopa; D004298:Dopamine