[Circadian rhythms in hepatic biotransformation of drugs].
The temporal variations in hepatic drug biotransformation are reviewed. Important diurnal variations in the activity of different cytochrome P-450 isoenzymes and in enzyme systems involved in conjugation to glucuronide, sulfate and acetate are described. A circadian rhythm in the hepatic concentration of glutathione is also described. These temporal variations explain the chronopharmacokinetic and chronohepatotoxicity of some drugs or toxic agents.
Bélanger
P M
PM
Ecole de pharmacie, Pavillon Vandry, Université Laval, Québec, Canada.
D000818:Animals; D001711:Biotransformation; D002940:Circadian Rhythm; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005965:Glucuronates / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008862:Microsomes, Liver / Q000201:enzymology
D005965:Glucuronates; D003577:Cytochrome P-450 Enzyme System; D005978:Glutathione
Rythmes circadiens de la biotransformation hépatique des médicaments.