CYP 2D6 PM phenotype hypothesis of antidepressant extrapyramidal side-effects.
Extrapyramidal symptoms occur as side-effects of neuroleptics. For many years, case reports of such side-effects, linked to antidepressant treatments, have been published, but this phenomenon is not well known. Tricyclic and serotonergic antidepressants are both involved. The authors present an hypothesis which provides one possible neurobiochemical explanation for the aetiology of these side-effects. The proposed explanation is related to the inhibition of the CYP 2D6 isoenzyme by antidepressants (or neuroleptics) that may be involved in the genesis of the observed extrapyramidal side-effects.
Vandel
P
P
Service de Psychiatrie et Psychologie Médicale, CHU 25030, Besançon, France.
Bonin
B
B
Vandel
S
S
Sechter
D
D
Bizouard
P
P
D000928:Antidepressive Agents / Q000009:adverse effects*; D001480:Basal Ganglia Diseases / Q000139:chemically induced* / Q000201:enzymology*; D019389:Cytochrome P-450 CYP2D6 / Q000172:deficiency / Q000235:genetics; D065690:Cytochrome P-450 CYP2D6 Inhibitors; D004791:Enzyme Inhibitors / Q000009:adverse effects; D006801:Humans; D008954:Models, Biological; D010641:Phenotype
D000928:Antidepressive Agents; D065690:Cytochrome P-450 CYP2D6 Inhibitors; D004791:Enzyme Inhibitors; D019389:Cytochrome P-450 CYP2D6