title: Vesiculobullous Hailey-Hailey disease: successful treatment with oral retinoids.
abstract: A 56-year-old male presented with a pruritic, generalized vesiculobullous eruption. His past history revealed classical symptoms of limited Hailey-Hailey disease for 34 years. Clinically, vesicles, bullae and occasional pustules were present and multiple biopsies confirmed this to be an unusual presentation of Hailey-Hailey disease. Various therapeutic modalities including topical and oral antibiotics, oral prednisone and dapsone failed to achieve sustained remission. Treatment with low-dose oral etretinate (25 mg daily) produced marked clinical improvement with complete suppression of new vesicle formation after 6 weeks.
authors.affiliation: Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
authors.forename: M J
authors.initials: MJ
authors.lastname: Hunt
authors.forename: E L
authors.initials: EL
authors.lastname: Salisbury
authors.forename: D M
authors.initials: DM
authors.lastname: Painter
authors.forename: S
authors.initials: S
authors.lastname: Lee
mesh_terms: D000284:Administration, Oral; D004305:Dose-Response Relationship, Drug; D005050:Etretinate / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016506:Pemphigus, Benign Familial / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*
chemical_list: D007641:Keratolytic Agents; D005050:Etretinate