title: HLA associations in otosclerosis in Japanese patients.
abstract: Otosclerosis is a disease of the otic capsule that is caused by abnormal resorption and redeposition of bony tissue. Sixty-two unrelated Japanese patients exhibiting clinical otosclerosis were typed for HLA-A, -B, -C antigens. Twenty-one of the patients were also typed for DR antigens. The frequency of HLA-Aw33 was significantly higher in otosclerosis patients than in the control group (24.2% vs 9.5%). This finding suggests that the presence of HLA-Aw33 antigens may be related to an increased susceptibility to otosclerosis or to its clinical outcome.
authors.affiliation: Department of Otorhinolaryngology, School of Medicine, Nagoya University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miyazawa
authors.forename: C
authors.initials: C
authors.lastname: Tago
authors.forename: H
authors.initials: H
authors.lastname: Ueda
authors.forename: H
authors.initials: H
authors.lastname: Niwa
authors.forename: N
authors.initials: N
authors.lastname: Yanagita
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People; D016009:Chi-Square Distribution; D004198:Disease Susceptibility; D005260:Female; D006680:HLA Antigens / Q000097:blood*; D006650:Histocompatibility Testing; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010040:Otosclerosis / Q000208:ethnology / Q000276:immunology*; D010641:Phenotype; D014680:Veins
chemical_list: D006680:HLA Antigens