title: Acute infection as a risk factor for ischemic stroke.
abstract: OBJECTIVE
  Prior studies have demonstrated that infections might precipitate ischemic strokes (IS), but the role of infection as a risk factor remains unclear. We conducted a case-control study to investigate this issue.
  
  
  METHODS
  Consecutive patients (n = 182) with acute IS were examined within 48 hours after admission to our center. A history of acute infections within 2 months before the IS was assessed by means of a specially designed questionnaire that was also given to a control group consisting of 194 consecutive patients who were seen in our outpatient clinic and had suffered IS at least 6 months previously.
  
  
  RESULTS
  The prevalence of acute infection in the study group was significantly higher (44/182 = 24.2%) than in the control group (19/194 = 9.7%; odds ratio, 2.93; 95% confidence interval, 1.64 to 5.26; P = .0002) and infection occurred mostly within 1 week before the IS (41/44). Neither the severity of the IS nor the type of the infection was significantly different in patients and control subjects.
  
  
  CONCLUSIONS
  Acute infections of different types constitute a risk factor for IS, particularly within 1 week of the event. However, the severity of the stroke is not related to this factor.
authors.affiliation: Department of Neurology, Tel Aviv Medical Center, Israel.
authors.forename: I Y
authors.initials: IY
authors.lastname: Bova
authors.forename: N M
authors.initials: NM
authors.lastname: Bornstein
authors.forename: A D
authors.initials: AD
authors.lastname: Korczyn
mesh_terms: D000208:Acute Disease; D000368:Aged; D002545:Brain Ischemia / Q000453:epidemiology* / Q000209:etiology; D016022:Case-Control Studies; D015897:Comorbidity; D006801:Humans; D007239:Infections / Q000150:complications / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors