[Symptomatic efficacy of clotrimazole combined with surgery in the treatment of recurring anal and genital condylomatosis in seropositive and AIDS patients].
During their daily surgical activity in Hiv-positive and AIDS patients the authors have seen in surgical treatment of anogenital recurring acuminate condylomata (treated with diatermocoagulation) in 1995 that prescribing elotrimazole ointment in Candida albicans infection of the same regions there was and amelioration or the healing of the mycotic infection but also a net lowering of the condylomata and persistent latency (disease-free time) till to the next local recurrence. So they have hypothesized and antiviral and antiblastic effect of elotrimazole. Under this heading they have done a literature research discovering that in 1995, only some months ago, two fundamental works have been published on this intriguing topic. They demonstrate at an experimental level in mice a strong antiviral and antiblastic activity of clotrimazole. This new fascinating field is completely open to future research and the consequences at a therapeutic level will be of utmost importance.
Erenbourg
L
L
Divisione di Chirurgia I, Ospedale San Raffaele-Milano.
Capasso
G
G
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D001004:Anus Diseases / Q000150:complications / Q000188:drug therapy* / Q000601:surgery*; D003022:Clotrimazole; D003131:Combined Modality Therapy; D003218:Condylomata Acuminata / Q000150:complications / Q000188:drug therapy* / Q000601:surgery*; D005260:Female; D005831:Genital Diseases, Female / Q000150:complications / Q000188:drug therapy* / Q000601:surgery*; D005832:Genital Diseases, Male / Q000150:complications / Q000188:drug therapy* / Q000601:surgery*; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D008297:Male
D000891:Anti-Infective Agents, Local; D003022:Clotrimazole
Efficacia sintomatica del clotrimazolo associato alla terapia chirurgica nel trattamento delle condilomatosi anali e genitali plurirecidivanti in pazienti sieropositivi ed affetti da AIDS. Comunicazione preliminare.