title: Midlatency auditory evoked potentials as indicators of perceptual processing during general anaesthesia.
abstract: We tested the hypothesis that midlatency auditory evoked potentials (MLAEP) can predict the occurrence of long latency AEP components (LLAEP), which are taken as evidence for perceptual processing. Forty-one patients undergoing cardiac surgery were anaesthetized with propofol and alfentanil. During several periods of surgery we recorded LLAEP. Peak-to-peak amplitude measures were used to determine if a particular LLAEP recording trace contained a recognizable waveform. Both before and after each LLAEP recording epoch, MLAEP and the spontaneous electroencephalogram (EEG) were recorded. Peak latencies and amplitudes of brainstem peak V and midlatency peaks Na, Pa, Nb, Pb and Nc, characteristic frequencies from the spontaneous EEG, mean arterial pressure (MAP) and nasopharyngeal temperature (7) were compared between recording epochs with and without clear LLAEP waveforms. These variables were also used in a discriminant analysis to predict the occurrence of an LLAEP waveform. Pa and Nb latencies were significantly shorter both before and after recording epochs in which an LLAEP waveform occurred, compared with epochs in which no LLAEP waveform occurred. Using a combination of up to six EEG, MLAEP, MAP and T measures, it was possible to predict the occurrence or absence of an LLAEP waveform with a sensitivity of 89% and specificity of 86%. We conclude that MLAEP components provide information on the possibility of perceptual processing during general anaesthesia, and thus may be relevant for monitoring depth of anaesthesia.
authors.affiliation: Department of Medical Electrical Engineering, Eindhoven University of Technology, The Netherlands.
authors.forename: N A
authors.initials: NA
authors.lastname: de Beer
authors.forename: J C
authors.initials: JC
authors.lastname: van Hooff
authors.forename: C H
authors.initials: CH
authors.lastname: Brunia
authors.forename: P J
authors.initials: PJ
authors.lastname: Cluitmans
authors.forename: H H
authors.initials: HH
authors.lastname: Korsten
authors.forename: J E
authors.initials: JE
authors.lastname: Beneken
mesh_terms: D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D018681:Anesthetics, General / Q000494:pharmacology*; D001307:Auditory Perception / Q000187:drug effects* / Q000502:physiology; D001794:Blood Pressure; D006348:Cardiac Surgical Procedures; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods*; D011930:Reaction Time / Q000187:drug effects; D012680:Sensitivity and Specificity
chemical_list: D018681:Anesthetics, General