Tensides from the group of propylene oxide and ethylene oxide copolymers. Part XI. Solubilization of acetylsalicylic acid (ASA) by monomethoxypoly(ethylene glycol) (M-PEG) micelles.
The process of structural solubilization of acetyl salicylic acid (ASA) in a balanced system (weight-balanced) by micelles of monomethoxypoly(ethylene glycol)-s-CH3OCH2[CH2OCH2]n-CH2OH (M(r) = 350-5000) types and, for comparison, by those of F-68 and F-108 Pluronics, was investigated. The determined viscosity and hydrodynamic parameters ([eta], KH, M eta, Robs, omega) allowed for the calculation of solubilizing activity of monomethoxypoly(ethylene glycol) micelles-pi s(ASA). The results of the investigation point at monomethoxypoly(ethylene glycol)s as an excipient, which may help to obtain new drug delivery systems.
Zgoda
M M
MM
Department of Applied Pharmacy, Faculty of Pharmacy, School of Medicine, Lódź, Poland.
D001241:Aspirin / Q000008:administration & dosage / Q000737:chemistry*; D008823:Micelles; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D012995:Solubility
D008823:Micelles; D011092:Polyethylene Glycols; C028210:monomethoxypolyethylene glycol; D001241:Aspirin