Neither protein kinase C nor adenylate cyclase are altered in the striatum from subjects with schizophrenia.
Dopamine (DA) D2 receptors which act by modulating second messenger pathways that include protein kinase C (PKC) and adenylate cyclase (AC) have been repeatedly shown to be increased in striatum from subjects with schizophrenia. Therefore it seemed possible that chronic up-regulation of DA-D2 receptors in the schizophrenic brain could result in a change in either of these two proteins. Hence we measured PKC and AC in striatum from 20 schizophrenic subjects and 20 non-schizophrenic subjects by quantitative autoradiography and could show no difference in the density of either PKC (436 +/- 35 vs. 485 +/- 29 fmol/mg tissue equivalents (TE), mean +/- SEM) or AC (77 +/- 9 vs. 80 +/- 7 fmol/mg TE) in the tissue from schizophrenic compared to the non-schizophrenic subjects. Thus, these data do not support the hypothesis that PKC or AC are changed in the schizophrenic brain.
Opeskin
K
K
Rebecca L. Cooper Laboratories, Mental Health Research Institute of Victoria, Parkville, Australia.
Dean
B
B
Pavey
G
G
Hill
C
C
Keks
N
N
Copolov
D
D
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000328:Adult; D000368:Aged; D001345:Autoradiography; D003342:Corpus Striatum / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011493:Protein Kinase C / Q000378:metabolism*; D012016:Reference Values; D012559:Schizophrenia / Q000201:enzymology* / Q000473:pathology; D012565:Schizophrenic Psychology
D011493:Protein Kinase C; D000262:Adenylyl Cyclases