title: [A comparative study of the effect of Zoladex treatment versus orchiectomy in patients with advanced prostatic cancer].
abstract: The study entered sixty patients with advanced carcinoma of the prostate that were treated and followed-up by the authors. The median age was 70.3 years (range 58-83 years). In all patients a prostatic carcinoma has been morphologically proven. Orchiectomy was performed in 27 of them. Conservative treatment with Zoladex-monotherapy was applied in 21 patients and a combination of orchiectomy plus Zoladex-in 12 of the remaining. All patients were followed-up for the period of 3 months. Subjective and objective parameters were evaluated at 2, 4, 8 and 12 weeks during the treatment. Positive response to treatment was reported in 76% of the patients from the group of orchiectomy alone, 72% among the patients in the group of Zoladex depot and up to 80% in patients treated with orchiectomy plus Zoladex. The average time to achieve positive response was stated to be seven weeks for orchiectomy and Zoladex as a monotherapy and six weeks for the combination therapy.
authors.forename: M
authors.initials: M
authors.lastname: Tsvetkov
authors.forename: Kh
authors.initials: Kh
authors.lastname: Kumanov
authors.forename: V
authors.initials: V
authors.lastname: Milkov
authors.forename: D
authors.initials: D
authors.lastname: Mladenov
authors.forename: K
authors.initials: K
authors.lastname: Neĭkov
mesh_terms: D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D003131:Combined Modality Therapy; D004341:Drug Evaluation; D017273:Goserelin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009919:Orchiectomy / Q000706:statistics & numerical data; D011471:Prostatic Neoplasms / Q000097:blood / Q000628:therapy*; D012074:Remission Induction; D013997:Time Factors
chemical_list: D018931:Antineoplastic Agents, Hormonal; D017273:Goserelin
vernacular_title: Sravnitelno prouchvane efekta ot lechenieto sŭs Zoladex spriamo orkhiektomiiata pri bolni s naprednal rak na prostatnata zhleza.