[A comparative study of the effect of Zoladex treatment versus orchiectomy in patients with advanced prostatic cancer].
The study entered sixty patients with advanced carcinoma of the prostate that were treated and followed-up by the authors. The median age was 70.3 years (range 58-83 years). In all patients a prostatic carcinoma has been morphologically proven. Orchiectomy was performed in 27 of them. Conservative treatment with Zoladex-monotherapy was applied in 21 patients and a combination of orchiectomy plus Zoladex-in 12 of the remaining. All patients were followed-up for the period of 3 months. Subjective and objective parameters were evaluated at 2, 4, 8 and 12 weeks during the treatment. Positive response to treatment was reported in 76% of the patients from the group of orchiectomy alone, 72% among the patients in the group of Zoladex depot and up to 80% in patients treated with orchiectomy plus Zoladex. The average time to achieve positive response was stated to be seven weeks for orchiectomy and Zoladex as a monotherapy and six weeks for the combination therapy.
Tsvetkov
M
M
Kumanov
Kh
Kh
Milkov
V
V
Mladenov
D
D
Neĭkov
K
K
D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D003131:Combined Modality Therapy; D004341:Drug Evaluation; D017273:Goserelin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009919:Orchiectomy / Q000706:statistics & numerical data; D011471:Prostatic Neoplasms / Q000097:blood / Q000628:therapy*; D012074:Remission Induction; D013997:Time Factors
D018931:Antineoplastic Agents, Hormonal; D017273:Goserelin
Sravnitelno prouchvane efekta ot lechenieto sŭs Zoladex spriamo orkhiektomiiata pri bolni s naprednal rak na prostatnata zhleza.