Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons.
Specific families of transcription factors mediate events in the sequential maturation of distinct neuronal phenotypes. Members of one such family, the class IV POU domain transcription factor Brn-3.0, and two highly related factors Brn-3.1 and Brn-3.2, are differentially expressed in the developing and mature mammalian nervous system. The expression pattern of Brn-3.0 suggested that it has an important role in the development of sensory ganglia, as well as red nucleus, inferior olive, and nucleus ambiguus. Analysis of mice null for the Brn-3.0 locus shows that Brn-3.0 is required for the survival of subpopulations of proprioceptive, mechanoreceptive and nociceptive sensory neurons, where deletion of the gene affects neurotrophin and neurotrophin-receptor gene expression. Deletion of Brn-3.0 also alters either differentiation, migration or survival of specific central neuronal populations.
McEvilly
R J
RJ
Howard Hughes Medical Institute, University of California, San Diego, USA.
Erkman
L
L
Luo
L
L
Sawchenko
P E
PE
Ryan
A F
AF
Rosenfeld
M G
MG
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics; D002454:Cell Differentiation; D002470:Cell Survival; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000502:physiology; D017950:Ganglia, Sensory / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D015870:Gene Expression; D018390:Gene Targeting; D008526:Medulla Oblongata / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D051379:Mice; D009046:Motor Neurons / Q000166:cytology* / Q000378:metabolism; D009414:Nerve Growth Factors / Q000502:physiology; D009475:Neurons, Afferent / Q000166:cytology* / Q000378:metabolism; D009847:Olivary Nucleus / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D020801:Receptor, Ciliary Neurotrophic Factor; D020800:Receptor, Nerve Growth Factor; D020812:Receptor, trkC; D017475:Receptors, Nerve Growth Factor / Q000235:genetics; D012012:Red Nucleus / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D013234:Stem Cells; D050818:Transcription Factor Brn-3; D050819:Transcription Factor Brn-3A; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology
D019208:Brain-Derived Neurotrophic Factor; D004268:DNA-Binding Proteins; D009414:Nerve Growth Factors; C494189:Pou4f1 protein, mouse; D020801:Receptor, Ciliary Neurotrophic Factor; D020800:Receptor, Nerve Growth Factor; D017475:Receptors, Nerve Growth Factor; D050818:Transcription Factor Brn-3; D050819:Transcription Factor Brn-3A; D014157:Transcription Factors; D020794:Receptor Protein-Tyrosine Kinases; D020812:Receptor, trkC