title: Identification of binding sites for calcium channel antagonists.
abstract: The binding sites of three typical calcium channel antagonists, 1, 4-dihydropyridines, benzothiazepines and phenylalkylamines, were successfully identified within the primary structures of calcium channels using a photoaffinity labeling technique. The results confirm pharmacological observations of the three antagonists that had been proposed to interact allosterically with each other. We briefly review the results and discuss the future prospects.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakayama
authors.forename: A
authors.initials: A
authors.lastname: Kuniyasu
mesh_terms: D000345:Affinity Labels; D001552:Benzazepines / Q000378:metabolism; D001665:Binding Sites; D002121:Calcium Channel Blockers / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D015220:Calcium Channels / Q000378:metabolism*; D004095:Dihydropyridines / Q000378:metabolism; D004110:Diltiazem / Q000378:metabolism; D004347:Drug Interactions; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism*; D013841:Thiazepines / Q000378:metabolism; D014700:Verapamil / Q000031:analogs & derivatives / Q000378:metabolism
chemical_list: D000345:Affinity Labels; D001552:Benzazepines; D002121:Calcium Channel Blockers; D015220:Calcium Channels; D004095:Dihydropyridines; D013841:Thiazepines; C038806:1,4-dihydropyridine; D014700:Verapamil; D004110:Diltiazem