title: Eosinophilia as a marker of adrenal insufficiency in the surgical intensive care unit.
abstract: BACKGROUND
  Because hemodynamic instability may have several causes in critically ill patients, adrenal insufficiency may not be readily diagnosed. Eosinophilia has been described in patients with chronic adrenal insufficiency but not in critically ill patients. The goal of this study was to determine whether eosinophilia could serve as a marker of adrenal insufficiency in critically ill patients.
  
  
  METHODS
  During a 1-year period, all surgical patients admitted to the surgical intensive care unit with an eosinophil count greater than 3 percent were prospectively studied. To diagnose adrenal insufficiency, the synthetic corticotropin (cosyntropin) stimulation test was used.
  
  
  RESULTS
  Eosinophilia was diagnosed in 31 patients, 7 (23 percent) of whom had adrenal insufficiency. The mean time interval to diagnosis was 13.7 days (range, 4 to 39 days). In 82 percent of the patients treated with hydrocortisone, a response was evidenced within 24 hours of treatment by a decrease in the required inotropic support by more than 50 percent, an increase in the mean arterial blood pressure of more than 25 percent, or both.
  
  
  CONCLUSIONS
  New-onset eosinophilia may be a useful marker for adrenal insufficiency. Prompt testing and diagnosis may avoid the occurrence of a treatable, life-threatening condition.
authors.affiliation: University of Hawaii Integrated Surgical Residency Program, Honolulu, USA.
authors.forename: M
authors.initials: M
authors.lastname: Angelis
authors.forename: M
authors.initials: M
authors.lastname: Yu
authors.forename: D
authors.initials: D
authors.lastname: Takanishi
authors.forename: N W
authors.initials: NW
authors.lastname: Hasaniya
authors.forename: M R
authors.initials: MR
authors.lastname: Brown
mesh_terms: D000304:Adrenal Cortex Function Tests; D000309:Adrenal Insufficiency / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D015415:Biomarkers; D001794:Blood Pressure / Q000187:drug effects; D003422:Critical Care; D004802:Eosinophilia / Q000175:diagnosis*; D004804:Eosinophils / Q000473:pathology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000627:therapeutic use; D007362:Intensive Care Units; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D006854:Hydrocortisone