Goodpasture's syndrome superimposed on membranous nephropathy. A case report.
We describe a patient with idiopathic membranous glomerulopathy who developed acute deterioration in renal function; this was associated with hemoptysis, severe hypertension, and anti-glomerular basement membrane (anti-GBM) antibody in the serum. Despite aggressive therapy with plasmapheresis, cyclophosphamide and prednisone, the patient progressed to end-stage renal failure and is on maintenance hemodialysis.
Thitiarchakul
S
S
Department of Internal Medicine, University of Missouri Health Sciences Center, Columbia, 65212, USA.
Lal
S M
SM
Luger
A
A
Ross
G
G
D019867:Anti-Glomerular Basement Membrane Disease / Q000503:physiopathology*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000906:Antibodies / Q000097:blood; D001485:Basement Membrane / Q000378:metabolism; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use; D015433:Glomerulonephritis, Membranous / Q000503:physiopathology / Q000628:therapy*; D006469:Hemoptysis / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000628:therapy; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000628:therapy*; D007677:Kidney Function Tests; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009549:Nigeria; D010956:Plasmapheresis; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D000906:Antibodies; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011241:Prednisone