Vesiculobullous Hailey-Hailey disease: successful treatment with oral retinoids.
A 56-year-old male presented with a pruritic, generalized vesiculobullous eruption. His past history revealed classical symptoms of limited Hailey-Hailey disease for 34 years. Clinically, vesicles, bullae and occasional pustules were present and multiple biopsies confirmed this to be an unusual presentation of Hailey-Hailey disease. Various therapeutic modalities including topical and oral antibiotics, oral prednisone and dapsone failed to achieve sustained remission. Treatment with low-dose oral etretinate (25 mg daily) produced marked clinical improvement with complete suppression of new vesicle formation after 6 weeks.
Hunt
M J
MJ
Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
Salisbury
E L
EL
Painter
D M
DM
Lee
S
S
D000284:Administration, Oral; D004305:Dose-Response Relationship, Drug; D005050:Etretinate / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016506:Pemphigus, Benign Familial / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*
D007641:Keratolytic Agents; D005050:Etretinate