Testicular toxicity evaluation of arsenic-containing binary compound semiconductors, gallium arsenide and indium arsenide, in hamsters.
The testicular toxicities of gallium arsenide (GaAs), indium arsenide (InAs) and arsenic trioxide (As2O3) were examined by repetitive intratracheal instillation using hamsters. GaAs (7.7 mg/kg) and As2O3 (1.3 mg/kg) were instilled twice a week a total of 16 times and InAs (7.7 mg/kg) was instilled a total of 14 times. GaAs caused testicular spermatid retention and epididymal sperm reduction, though the degrees were less severe than those in rats shown in our previous experiment. InAs and As2O3 did not show any testicular toxicities. Serum arsenic concentration in GaAs-treated hamsters was less than half of that in As2O3-treated hamsters in which no testicular toxicities were found. Serum molar concentration of gallium was 32-times higher than that of arsenic in GaAs-treated hamsters. Therefore gallium may play a main role in the testicular toxicity of GaAs in hamsters.
Omura
M
M
Department of Hygiene, Faculty of Medicine, Kyushu University, Fukuoka, Japan. momura@eisei.med.kyushuu.ac.jp
Hirata
M
M
Tanaka
A
A
Zhao
M
M
Makita
Y
Y
Inoue
N
N
Gotoh
K
K
Ishinishi
N
N
D000818:Animals; D001151:Arsenic / Q000097:blood; D020261:Arsenic Poisoning; D001152:Arsenicals / Q000008:administration & dosage; D001835:Body Weight / Q000187:drug effects; D006224:Cricetinae; D004822:Epididymis / Q000187:drug effects; D005708:Gallium / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D007204:Indium / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D007442:Intubation, Intratracheal; D008297:Male; D009929:Organ Size / Q000187:drug effects; D013076:Sperm Count / Q000187:drug effects; D013087:Spermatids / Q000187:drug effects; D013737:Testis / Q000187:drug effects* / Q000473:pathology
D001152:Arsenicals; D007204:Indium; C043055:gallium arsenide; D005708:Gallium; C076773:indium arsenide; D001151:Arsenic