Synthesis and biological activities of some 7,8-dihydroimidazo[1,2-a]-1,3,5-triazine derivatives.
The alkylation of 7,8-dihydroimidazo[1,2-a]-1,3,5-triazine-2,4-(3H,6H)-dithione [I] with 2-chloro-N-arylacetamides gave 2-alkyltio derivatives [III]. Further reactions of 2-(alkyltio)-7,8-dihydroimidazo[1,2-a]-1,3,5-triazine-4(6H)- thiones [III] or [IV] with aryl isothiocyanates, sulfochlorides or 2-bromo-1-phenylethanone afforded corresponding B-substituted products [V,VI,VII].
Saczewski
F
F
Department of Organic Chemistry, Medical University of Gdańsk, Poland.
Nasal
A
A
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D051381:Rats; D013055:Spectrophotometry, Infrared; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology*
D007093:Imidazoles; D014227:Triazines