title: Peptidyl conjugates of adenosine 5'-carboxylic acid synthesized and evaluated as ligands for P2 purinoceptors.
abstract: The role of extracellular ATP in vivo and the various cellular responses mediated by P2 purinoceptors have not yet been fully elucidated, in part depending on the lack of subtype-specific high affinity antagonists. Here we describe the synthesis of a new class of compounds, peptidyl derivatives of adenosine 5'-carboxylic acid, among which some have inhibitory effects in certain P2 purinoceptor-carrying biological systems, e.g., glioma and smooth muscle cell lines and isolated smooth muscle tissue preparations from guinea pig vas deferens and urinary bladder.
authors.affiliation: Department of Neurochemistry and Neurotoxicology, Arrhenius Laboratories for Natural Sciences, Stockholm University, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Järlebark
authors.forename: M
authors.initials: M
authors.lastname: Erlandsson
authors.forename: A
authors.initials: A
authors.lastname: Uri
authors.forename: B F
authors.initials: BF
authors.lastname: King
authors.forename: A U
authors.initials: AU
authors.lastname: Ziganshin
authors.forename: C
authors.initials: C
authors.lastname: Johansson
authors.forename: E
authors.initials: E
authors.lastname: Heilbronn
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D009130:Muscle, Smooth / Q000378:metabolism / Q000502:physiology; D010455:Peptides / Q000737:chemistry*; D058910:Purinergic P2 Receptor Agonists; D058919:Purinergic P2 Receptor Antagonists; D011817:Rabbits; D051381:Rats; D018048:Receptors, Purinergic P2 / Q000378:metabolism*; D011994:Recombinant Proteins / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism; D014407:Tumor Cells, Cultured; D014981:Xenopus
chemical_list: D008024:Ligands; D010455:Peptides; D058910:Purinergic P2 Receptor Agonists; D058919:Purinergic P2 Receptor Antagonists; D018048:Receptors, Purinergic P2; D011994:Recombinant Proteins; C102887:adenosine-5'-carboxylic acid; D000241:Adenosine