title: [Seroprevalence of viral hepatitis A in France in homosexuals and intravenous drug users].
abstract: OBJECTIVE
  In industrialized countries with a high level of sanitation, immunity against hepatitis A (HVA) is not acquired during childhood, and infection typically occurs in adults, mainly in travelers returning from developing countries where infection is endemic. However, the introduction of hepatitis A virus (HAV) among certain population groups, such as intravenous drug users (IVDU) or homosexual men, leads to a significant increase in the disease. We conducted a retrospective analysis of seroprevalence of anti-HAV antibodies.
  
  
  METHODS
  The study group included 296 patients (174 homosexual men and 122 IVDU) for comparison with 76 control subjects (nurses in pediatric wards and workers in hospital kitchen).
  
  
  RESULTS
  We found a significantly higher anti-HAV seroprevalence among less than 35-year old IVDU, HIV positive or negative, in comparison with control subjects but not among homosexual men, whatever their HIV status.
  
  
  CONCLUSIONS
  Our experience illustrates that HVA is a health risk for IVDU in industrialized nations, and given its morbidity among adults population, IVDU should receive HVA vaccine.
authors.affiliation: Service des Maladies infectieuses et tropicales, CHU de Saint-Etienne.
authors.forename: F
authors.initials: F
authors.lastname: Lucht
authors.forename: P
authors.initials: P
authors.lastname: Berthelot
authors.forename: P
authors.initials: P
authors.lastname: Job
authors.forename: L
authors.initials: L
authors.lastname: Bonnevial
authors.forename: C
authors.initials: C
authors.lastname: Digonnet
authors.forename: A
authors.initials: A
authors.lastname: Fresard
authors.forename: B
authors.initials: B
authors.lastname: Chabert
authors.forename: C
authors.initials: C
authors.lastname: Cabal
authors.forename: B
authors.initials: B
authors.lastname: Pozzetto
mesh_terms: D000328:Adult; D005260:Female; D005602:France / Q000453:epidemiology; D006506:Hepatitis A / Q000453:epidemiology* / Q000276:immunology / Q000635:transmission; D006508:Hepatitis Antibodies / Q000032:analysis*; D018451:Homosexuality, Male; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D015819:Substance Abuse, Intravenous
chemical_list: D006508:Hepatitis Antibodies
vernacular_title: Séroprévalence de l'hépatite virale A en France métropolitaine chez les homosexuels et les toxicomanes intraveineux.