Identification of flecainide and lorcainide in blood by means of TLC.
New antiarrhythmics-flecainide and lorcainide-extracted from plasma were separated by TLC method on silica gel by ascending development, using suitable mobile phases. The substances were identified by reaction with indicators: Dragendorff reagent for lorcainide (up to the amount 50 ng) and acidified 15% FeCl3, followed by 15% KI and water for flecainide (up to the amount 500 ng).
Paw
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Department of Medicinal Chemistry, Faculty of Pharmacy, School of Medicine, Lublin, Poland.
Przyborowski
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L
D000889:Anti-Arrhythmia Agents / Q000032:analysis*; D044482:Benzeneacetamides; D002855:Chromatography, Thin Layer; D005424:Flecainide / Q000097:blood*; D006801:Humans; D010880:Piperidines / Q000097:blood*
D000889:Anti-Arrhythmia Agents; D044482:Benzeneacetamides; D010880:Piperidines; D005424:Flecainide; C015970:lorcainide