Late complications of immune deviation therapy in a nonhuman primate.
The administration of antigens in soluble form can induce antigen-specific immune tolerance and suppress experimental autoimmune diseases. In a marmoset model of multiple sclerosis induced by myelin oligodendrocyte glycoprotein (MOG), marmosets tolerized to MOG were protected against acute disease, but after tolerization treatment a lethal demyelinating disorder emerged. In these animals, MOG-specific T cell proliferative responses were transiently suppressed, cytokine production was shifted from a T helper type 1 (TH1) to a TH2 pattern, and titers of autoantibodies to MOG were enhanced. Thus, immune deviation can increase concentrations of pathogenic autoantibodies and in some circumstances exacerbate autoimmune disease.
Genain
C P
CP
Department of Neurology, University of California, San Francisco, CA 94143, USA.
Abel
K
K
Belmar
N
N
Villinger
F
F
Rosenberg
D P
DP
Linington
C
C
Raine
C S
CS
Hauser
S L
SL
D000818:Animals; D000954:Antigens, Surface / Q000276:immunology*; D001323:Autoantibodies / Q000096:biosynthesis; D001921:Brain / Q000473:pathology; D002144:Callithrix; D016207:Cytokines / Q000235:genetics; D003711:Demyelinating Diseases; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D015870:Gene Expression; D007108:Immune Tolerance; D007167:Immunotherapy / Q000009:adverse effects*; D008213:Lymphocyte Activation; D009103:Multiple Sclerosis / Q000276:immunology / Q000628:therapy; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein / Q000276:immunology*; D063308:Myelin-Oligodendrocyte Glycoprotein; D011994:Recombinant Proteins / Q000276:immunology; D012995:Solubility; D013116:Spinal Cord / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D000954:Antigens, Surface; D001323:Autoantibodies; D016207:Cytokines; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D011994:Recombinant Proteins