[Practicability, effectiveness and tolerance of a standardized prepared theophylline infusion].
The practicality, efficacy, and tolerance of a standardized, ready-to-use theophylline solution (Eloasthmin, Leopold Pharma, Graz) was studied on 33 patients with bronchial asthma and/or chronic obstructive bronchitis (COPD) (19 males, 14 females) aged 19 to 79 (median 50) years. Eloasthmin a ready-to-use pure theophylline solution containing no auxilliary substances, contains one gram theophyllin per liter in a hypotonic (2/3) NaCl solution. The infusion therapy was carried out in patients in an acute stage of their chronic obstructive ventilation dysfunction. The therapy was carried out for 2 to 4 days at a dose of 400 to 1000 mg theophylline per day, so that theophylline blood levels remained within the therapeutic range of 8 to 20 mg/ml. A highly significant improvement (p < 0.001) of lung function parameters was seen during treatment: VC before therapy = 2.46 l, after therapy = 3.36 l; FEV 1 before therapy = 1.34 l, after therapy = 2.04 l; and PEF before therapy = 3.48 l/s after therapy = 5.13 l/s. Since most patients also received concomittant medication (beta 2-sympathomimetica and/or glucocorticoids), it was difficult to differentiate the specific efficacy of the theophylline.
Pohl
W R
WR
II. Medizinischen Abteilung und Pulmologie, Wilhelminenspitals der Stadt Wien.
Kummer
F
F
Lorber
H
H
Würtz
J
J
Aigner
K
K
Pfeiffer
K P
KP
D000328:Adult; D000368:Aged; D001249:Asthma / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008173:Lung Diseases, Obstructive / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013806:Theophylline / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D014797:Vital Capacity / Q000187:drug effects
D013806:Theophylline
Praktikabilität, Wirksamkeit und Verträglichkeit einer standardisierten Theophyllin-Fertiginfusion.