title: Noise in models of neurological and psychiatric disorders.
abstract: The concept of noise has only recently been applied to modelling neuropsychiatric disorders. Two examples of such models are presented. 1. A phantom limb is a neurological condition after the amputation of an extremity. It consists of sensations of the presence of the lost limb and has been attributed to cortical as well as non-cortical mechanisms. A neural network model of phantom limbs is proposed which can parsimoniously account for a large number of clinical features and recent findings of cortical map plasticity after deafferentation. In trained self-organizing feature maps, deafferentation was simulated. Reorganization is shown to be driven by input noise. According to the model, the production of input noise by the deafferented primary sensory neuron drives cortical reorganization in amputees. No such noise is generated and/or conducted to the cortex in paraplegics. 2. Several clinical features of schizophrenia have been related to the ratio of signal to noise in neuronal information processing. In particular, dopamine--which has been implicated in the causation of schizophrenia for decades--has been proposed to modulate signal-to-noise ratio. Data are presented which suggest that schizophrenic thought disorder is the result of a hypodopaminergic state and concomitant increased effects of noise in semantic information processing. Possible functions of noise in the nervous systems are discussed.
authors.affiliation: Department of Psychiatry, University of Heidelberg, Germany. Manfred_Spitzer@krzmail.krz.uni-heidelberg.de
authors.forename: M
authors.initials: M
authors.lastname: Spitzer
authors.forename: M
authors.initials: M
authors.lastname: Neumann
mesh_terms: D003198:Computer Simulation; D006801:Humans; D008959:Models, Neurological; D016571:Neural Networks, Computer; D009473:Neuronal Plasticity / Q000502:physiology; D018377:Neurotransmitter Agents / Q000378:metabolism; D010591:Phantom Limb / Q000378:metabolism / Q000503:physiopathology*; D012559:Schizophrenia / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D018377:Neurotransmitter Agents