title: Morewright (mwr), a new meiotic mutant of Drosophila melanogaster affecting nonexchange chromosome segregation.
abstract: A new meiotic mutation, morewright (mwr) was identified by screening for new mutations that act as dominant enhancers of the dosage-sensitive Drosophila melanogaster female meiotic mutant, nodDTW.mwr is a recessive meiotic mutant, specifically impairing the segregation of nonexchange chromosomes. Cytological evidence suggests that the meiotic defect in mwr/mwr females is in homologue recognition because the chromosomes appear to be misaligned on an intact spindle. The mwr mutation was recovered during a screen of random P-element insertions on a chromosome with a single insertion located at 50C. The P-element insertion is a recessive female-sterile mutation. While excision of the P element from the mwr-bearing chromosome partially relieves the female sterility, the excisions retain the dominant nodDTW-enhancing activity. The mwr meiotic phenotype maps very close to the female-sterile P insertion. Thus the mwr locus appears to encode a function required for partner recognition in meiosis, although its relationship to the neighboring female-sterile mutation remains to be elucidated.
authors.affiliation: Department of Biology, St. John's University, Jamaica, New York 11439, USA. ybrtbio@sjumusic.stjohns.edu
authors.forename: R S
authors.initials: RS
authors.lastname: Rasooly
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D004251:DNA Transposable Elements / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D017344:Genes, Insect; D019476:Insect Proteins / Q000235:genetics*; D008540:Meiosis / Q000235:genetics; D009154:Mutation; D011995:Recombination, Genetic
chemical_list: D004251:DNA Transposable Elements; D019476:Insect Proteins