title: High dose adenosine stress echocardiography for noninvasive detection of coronary artery disease.
abstract: OBJECTIVE
  The aim of this study was to assess the tolerability and incremental diagnostic value of high adenosine doses in stress echocardiography testing in patients with coronary artery disease (CAD).
  
  
  BACKGROUND
  In comparison with other pharmacologic stress echocardiography tests, standard dose adenosine stress has sub-optimal sensitivity for detecting milder forms of CAD.
  
  
  METHODS
  Adenosine stress echocardiography was performed in 58 patients using a starting dose of 100 micrograms/kg body weight per min over 3 min followed by 140 micrograms/kg per min over 4 min (standard dose). If no new wall motion abnormality appeared, the dose was increased to 200 micrograms/kg per min over 4 min (high dose). All patients underwent coronary angiography. Significant CAD was defined as > or = 50% diameter stenosis in at least one major coronary artery. Thirty-three patients had one-vessel and seven had multivessel CAD. Coronary angiographic findings were normal in 18 patients.
  
  
  RESULTS
  The high adenosine dose caused a slight but significant increase over baseline values in rate-pressure product. Limiting side effects occurred in two patients during the standard dose protocol and in one patient receiving the high dose regimen. The test was stopped in 30 patients after the standard adenosine dose regimen because of a provoked new wall motion abnormality. The sensitivity of adenosine echocardiography with the standard dose was 75% (95% confidence interval [CI] 63% to 87%). After completion of the standard dose protocol, 28 patients continued testing with the high dose adenosine protocol. The overall sensitivity of adenosine echocardiography, calculated as cumulative, increased to 92% (95% CI 84% to 100%) with the high dose (p < 0.05). The specificity of adenosine testing was 100% and 88%, respectively, with the standard and high dose regimen (p = 0.617).
  
  
  CONCLUSIONS
  We believe that use of a higher than usual adenosine dose protocol for stress testing may improve the diagnostic value of adenosine echocardiography, mainly by increasing sensitivity in patients with single-vessel disease without deterioration of the safety profile and with only a mild reduction in specificity.
authors.affiliation: University Institute for Cardiovascular Diseases, Department of Diagnostic and Catheterization Laboratories, Belgrade, Yugoslavia.
authors.forename: A D
authors.initials: AD
authors.lastname: Djordjevic-Dikic
authors.forename: M C
authors.initials: MC
authors.lastname: Ostojic
authors.forename: B D
authors.initials: BD
authors.lastname: Beleslin
authors.forename: J
authors.initials: J
authors.lastname: Stepanovic
authors.forename: Z
authors.initials: Z
authors.lastname: Petrasinovic
authors.forename: R
authors.initials: R
authors.lastname: Babic
authors.forename: S M
authors.initials: SM
authors.lastname: Stojkovic
authors.forename: G
authors.initials: G
authors.lastname: Stankovic
authors.forename: M
authors.initials: M
authors.lastname: Nedeljkovic
authors.forename: I
authors.initials: I
authors.lastname: Nedeljkovic
authors.forename: V
authors.initials: V
authors.lastname: Kanjuh
mesh_terms: D000241:Adenosine; D001794:Blood Pressure; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D015588:Observer Variation; D012680:Sensitivity and Specificity; D014463:Ultrasonography; D014665:Vasodilator Agents
chemical_list: D014665:Vasodilator Agents; D000241:Adenosine