Studies on new antitumor antibiotics, leptofuranins A, B, C and D II. Physiocochemical properties and structure elucidation.
The structures of new antitumor antibiotics, leptofuranins A, B, C and D were elucidated to be as shown in Fig. 1 by NMR spectral analysis including a variety of two-dimensional techniques. The leptofuranins are novel leptomycin-related substances containing a tetrahydrofuran ring. Leptofuranins C and D were revealed to be in tautomeric isomerism and their relative stereochemistries were analyzed by NOESY experiments.
Hayakawa
Y
Y
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Sohda
K
K
Seto
H
H
D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D002247:Carbon Isotopes; D005663:Furans / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry
D000903:Antibiotics, Antineoplastic; D002247:Carbon Isotopes; D005663:Furans; D011753:Pyrones; C103028:leptofuranin A; C103029:leptofuranin B; C103030:leptofuranin C; C103031:leptofuranin D