Esters of cephalosporins. Part IV. Hydrolysis of 1-acetoxyethyl ester of cefuroxime in vitro and in vivo.
Hydrolysis of 1-acetoxyethyl ester of cefuroxime [I] in blood was studied in vitro and in vivo. In vitro [I] hydrolyzes to biological active cefuroxime [II] and at the same time it undergoes isomerization to isomer delta 2 of 1-acetoxyethyl ester of cefuroxime [IV] and next hydrolyzes to biological inactive isomer delta 2 of cefuroxime [V]. As a result of hydrolysis [I] in vivo only [II] is formed.
Tejchman
B
B
Department of Chemical Analysis, Institute of Biotechnology and Antibiotics, Warsaw, Poland.
Jaromińska
M
M
Horodecka
M
M
Oszczapowicz
I
I
D001769:Blood / Q000378:metabolism*; D002444:Cefuroxime / Q000031:analogs & derivatives* / Q000378:metabolism; D002511:Cephalosporins / Q000378:metabolism*; D006801:Humans; D011355:Prodrugs / Q000378:metabolism*
D002511:Cephalosporins; D011355:Prodrugs; D002444:Cefuroxime; C040738:cefuroxime axetil