[Drug-resistant tuberculosis at a general hospital].
OBJECTIVE
To determine the prevalence of M. tuberculosis isolates resistant to drugs in a general hospital and to assess its association with HIV infection.


METHODS
Susceptibility analysis of all isolates of M. tuberculosis in a 4-year period (1990-1993). The proportion method was used to study the susceptibility to eight drugs. To assess the association of resistance with HIV infection a crossing was made of patients records who had M. tuberculosis recovered and that of patients with positive serology to HIV.


RESULTS
Forty-two out of a total of 760 isolates (5.5%) were resistant to at least one drug, including isoniazid in 27 (3.3%), rifampin in 13 (1.6%), and pyrazinamide in 2 (0.2%). None of the isolates was resistant to ofloxacin. Twenty isolates (2.6%) were resistant to more than one drug and 9 (1.2%) were resistant to at least isoniazid and rifampin. Overall, 39% of resistance to one drug occurred in patients who had not received previous therapy with that drug. A greater incidence of resistant isolates was observed in HIV+ patients (7.3%) than in HIV- patients (4.6%), although this difference did not reach a statistical significance.


CONCLUSIONS
Drug resistance rate in M. tuberculosis isolates in our hospital is still low and apparently not associated with HIV infection.
Miralles Martín
P
P
Unidad de Enfermedades Infecciosas-VIH, Hospital General Universitario Gregorio Marañón, Madrid.
Moreno Guillén
S
S
Parras Vázquez
F
F
Cosín Ochaita
J
J
Cercenado Mansilla
E
E
Ortega Calderón
A
A
Bouza Santiago
E
E
D006769:Hospitals, General; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D015995:Prevalence; D013030:Spain; D018088:Tuberculosis, Multidrug-Resistant / Q000453:epidemiology* / Q000382:microbiology
Tuberculosis resistente a fármacos en un hospital general.