[Examination of percutaneous minocycline hydrochloride injection therapy for hepatic cyst by one puncture method].
Minocycline hydrochloride (MINO) at a dose of 500 mg (in principle) was injected into each of 11 hepatic cysts/10 cases (mean maximum diameter: 12.6 cm) that exhibited symptoms or a tendency toward growth by percutaneous transhepatic one puncture method, and the relation between therapeutic efficacy and pH of cystic fluid was examined. The efficacy was evaluated by abdominal CT after 3 months, and when a shrink of 50% or more in the maximum diameter was observed, it was judged as marked response. Marked effect was observed in 9 lesions of 11 (82%). This MINO injection therapy by one puncture method is very safe, simple and useful. Reduction in intra-cystic pH was not always related to the therapeutic efficacy, so involvement of cytotoxicity of MINO was suggested in degenerating the cystic epithelial cells.
Tanaka
Y
Y
Department of Gastroenterology, Nagoya Daini Red Cross Hospital.
Ogino
M
M
Tokuda
H
H
Mizuno
M
M
Yamauchi
M
M
Iijima
Y
Y
Hattori
K
K
Kato
T
T
Komatsubara
Y
Y
Kato
H
H
Hayashi
K
K
D000328:Adult; D000368:Aged; D003560:Cysts / Q000188:drug therapy*; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D008107:Liver Diseases / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000008:administration & dosage*; D016896:Treatment Outcome
D008911:Minocycline