title: Difference in response of D2 receptor binding between 11C-N-methylspiperone and 11C-raclopride against anesthetics in rhesus monkey brain.
abstract: The effects of anesthesia on dopamine D2 receptor binding in the rhesus monkey brain were examined using positron emission tomography. The bindings of 11C-N-methylspiperone (NMSP) and 11C-raclopride (RAC) were measured under controlled ketamine or isoflurane anesthesia. The binding of 11C-NMSP was significantly lower in the striatum anesthetized with isoflurane than with ketamine. There was a smaller change in the binding of 11C-RAC than of 11C-NMSP. These findings suggest that changes in 11C-NMSP or 11C-RAC binding induced by anesthetics were not due solely to changes in the competition of endogenous dopamine.
authors.affiliation: Department of Neurophysiology, Nippon Medical School, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: O
authors.initials: O
authors.lastname: Inoue
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Onoe
authors.forename: B
authors.initials: B
authors.lastname: Långström
mesh_terms: D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D002250:Carbon Radioisotopes; D018491:Dopamine Agonists / Q000378:metabolism; D018492:Dopamine Antagonists / Q000378:metabolism; D005260:Female; D007530:Isoflurane / Q000494:pharmacology; D007649:Ketamine / Q000494:pharmacology; D008253:Macaca mulatta / Q000378:metabolism*; D020891:Raclopride; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D012457:Salicylamides / Q000378:metabolism*; D013134:Spiperone / Q000031:analogs & derivatives* / Q000378:metabolism; D014055:Tomography, Emission-Computed
chemical_list: D000777:Anesthetics; D002250:Carbon Radioisotopes; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D017448:Receptors, Dopamine D2; D012457:Salicylamides; D020891:Raclopride; D013134:Spiperone; D007649:Ketamine; C039167:3-N-methylspiperone; D007530:Isoflurane