title: Proinflammatory and anti-inflammatory cytokines in meningococcal disease.
abstract: Interleukin-10 (IL-10), an anti-inflammatory cytokine, was measured in 131 children with meningococcal disease. IL-10 concentrations were significantly higher in children who died and correlated positively with proinflammatory cytokines. Children who die from meningococcal disease have high IL-10 concentrations, which do not suppress proinflammatory cytokines.
authors.affiliation: Institute of Child Health, University of Liverpool.
authors.forename: F A
authors.initials: FA
authors.lastname: Riordan
authors.forename: O
authors.initials: O
authors.lastname: Marzouk
authors.forename: A P
authors.initials: AP
authors.lastname: Thomson
authors.forename: J A
authors.initials: JA
authors.lastname: Sills
authors.forename: C A
authors.initials: CA
authors.lastname: Hart
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D008589:Meningococcal Infections / Q000276:immunology*; D011446:Prospective Studies; D012772:Shock, Septic / Q000276:immunology; D015996:Survival Rate; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10