title: [Changes in the gastric mucosa in endocrine-cell cancer].
abstract: Mucous membrane from different parts of the stomach has been studied in 53 surgical cases of stomach carcinoma. All the tumours were subdivided into endocrine-cell (EC) and non-endocrine-cell. The background in all cases was chronic gastritis which was most pronounced at the border with tumour and in the pyloro-antral part of the stomach. Hyperplasia of the fundal glands with hyperfunction of the chief and lining cells, hypersecretion of foveal epithelium, pseudo-pyloric metaplasia and helicobacteriosis were more frequent in EC-carcinomas. Dysplastic epithelial changes in EC were found in the lower third of the necks and terminal regions of the intermediar and pseudo-pyloric glands and in some cases in the foveolar epithelium and intestinal crypts. These features of the background and precancerous lesions in EC should be taken into consideration in diagnosis.
authors.forename: I S
authors.initials: IS
authors.lastname: Derizhanova
authors.forename: A Kh
authors.initials: AKh
authors.lastname: Salmn
mesh_terms: D001078:APUD Cells / Q000473:pathology*; D002908:Chronic Disease; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology*; D005756:Gastritis / Q000150:complications* / Q000382:microbiology; D016481:Helicobacter Infections / Q000150:complications; D006801:Humans; D006965:Hyperplasia; D008679:Metaplasia; D011706:Pyloric Antrum / Q000382:microbiology / Q000473:pathology; D013274:Stomach Neoplasms / Q000150:complications / Q000382:microbiology / Q000473:pathology*
vernacular_title: Izmeneniia slizistoĭ obolochki zheludka pri éndokrinnokletochnykh rakakh.