Injectable gold compounds: an overview.
Injectable gold compounds have enjoyed widespread, but occasionally controversial, use in rheumatoid arthritis since the 1920s. This overview examines the data from controlled trials and longer-term observational studies. We conclude that gold is equivalent to other widely used second-line agents in terms of efficacy. Toxicity profiles are similar, apart from methotrexate. It is most efficacious and toxic in the first 2 yr of treatment. There appears to be a dose-response relationship for both efficacy and toxicity. Gold is one of the few agents that decreases the rate of progression of erosions (RR 0.38, 95% CI 0.23-064). Gold compounds, therefore, have a definite place in the rheumatologist's armamentarium, but further research is required to determine optimal monitoring regimes as well as the role of maintenance therapy and combination therapy.
Jones
G
G
Menzies Centre for Population Health Research, Hobart, Tasmania, Australia.
Brooks
P M
PM
D018501:Antirheumatic Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000633:toxicity; D018849:Controlled Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D006801:Humans; D050607:Organogold Compounds
D018501:Antirheumatic Agents; D050607:Organogold Compounds