Hemodynamic effects of calcium gluconate administered to conscious horses.
Calcium gluconate was administered to conscious horses at 3 different rates (0.1, 0.2, and 0.4 mg/kg/min for 15 minutes each). Serum calcium concentrations and parameters of cardiovascular function were evaluated. All 3 calcium administration rates caused marked increases in both ionized and total calcium concentrations, cardiac index, stroke index, and cardiac contractility (dP/dtmax). Mean arterial pressure and right atrial pressure were unchanged; heart rate decreased markedly during calcium administration. Ionized calcium concentration remained between 54% and 57% of total calcium concentration throughout the study. We conclude that calcium gluconate can safely be administered to conscious horses at 0.1 to 0.4 mg/kg/min and that administration will result in improved cardiac function.
Grubb
T L
TL
Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, USA.
Foreman
J H
JH
Benson
G J
GJ
Thurmon
J C
JC
Tranquilli
W J
WJ
Constable
P D
PD
Olson
W O
WO
Davis
L E
LE
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002118:Calcium / Q000097:blood; D002125:Calcium Gluconate / Q000008:administration & dosage / Q000494:pharmacology*; D002302:Cardiac Output / Q000187:drug effects / Q000502:physiology; D003243:Consciousness / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006736:Horses / Q000097:blood / Q000502:physiology*; D007262:Infusions, Intravenous; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology; D012119:Respiration / Q000187:drug effects / Q000502:physiology; D013318:Stroke Volume / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
D002125:Calcium Gluconate; D002118:Calcium