title: Complications associated with therapeutic neck radiation.
abstract: OBJECTIVE
  This retrospective study of patients who underwent neck radiation as part of their treatment for squamous cell carcinoma of the oral cavity sought to identify and quantify the morbidity associated with this treatment.
  
  
  METHODS
  Thirty-five patients who received neck radiation between 1985 and 1992 were randomly recalled for examination. All patients had been treated in a standardized fashion by the Department of Radiation Oncology. The long-term effects of neck radiation on skin changes, thyroid function, and neck range of motion, of atherosclerotic carotid artery disease, xerostomia, and glottic structures were measured.
  
  
  RESULTS
  Fifty-seven percent of patients demonstrated grade 1 skin changes. No severe changes were noted, and no development of secondary neoplasia was observed. There was no linear trend observed between radiation dose and skin changes. Hypothyroidism developed in 14.3% of patients within 3.5 years posttreatment. Logistic regression demonstrated a significant association between hypothyroidism and radiation dose. Limitation of neck mobility was the most significant complication with deficits demonstrated in all ranges of motion. Carotid bruits were documented in 14.3% of patients, with a significant association between the higher neck dosage in N+ cases. Xerostomia was found in 68% of patients. There was persistent glottic erythema in 11.4% of patients.
  
  
  CONCLUSIONS
  The results of this study indicate that there are persistent complications after neck radiation, which include limitation of neck movement, diminished thyroid function, accelerated carotid artery narrowing, and skin and salivary changes.
authors.affiliation: Massachusetts General Hospital, Department of Oral and Maxillofacial Surgery, Harvard School of Dental Medicine, Boston 02114, USA.
authors.forename: M
authors.initials: M
authors.lastname: August
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: D
authors.initials: D
authors.lastname: Plante
authors.forename: C C
authors.initials: CC
authors.lastname: Wang
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D016893:Carotid Stenosis / Q000209:etiology; D004307:Dose-Response Relationship, Radiation; D005260:Female; D019416:Head Movements / Q000528:radiation effects*; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology; D007830:Larynx / Q000528:radiation effects; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000532:radiotherapy; D009333:Neck / Q000528:radiation effects*; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D016059:Range of Motion, Articular / Q000528:radiation effects; D012189:Retrospective Studies; D012867:Skin / Q000528:radiation effects; D014987:Xerostomia / Q000209:etiology