Hormonal regulation of cardiac cystic fibrosis transmembrane conductance regulator chloride channels.
The chloride conductance that arises from the stimulation of beta-adrenoceptors has been shown to be carried by a cardiac isoform of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels. This brief review will focus first upon the cellular signal transduction system for the activation of this type of Cl- channels and then its regulation by catecholamines, muscarinic agonists, endothelin-1 and angiotensin-II. Both in physiological and pathological conditions, the complex interaction of these agonists modulates the Cl- conductance, which is potentially arrhythmogenic by shortening the action potential duration and inducing the depolarization.
Horie
M
M
Third Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
Obayashi
K
K
Xie
L H
LH
James
A F
AF
Sasayama
S
S
D000200:Action Potentials / Q000502:physiology; D000262:Adenylyl Cyclases / Q000378:metabolism; D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology; D002395:Catecholamines / Q000502:physiology*; D018118:Chloride Channels / Q000502:physiology*; D000242:Cyclic AMP / Q000502:physiology; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000502:physiology*; D019332:Endothelin-1 / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000378:metabolism; D006321:Heart / Q000294:innervation; D009206:Myocardium / Q000378:metabolism*; D010766:Phosphorylation; D015398:Signal Transduction
D002395:Catecholamines; D018118:Chloride Channels; D019332:Endothelin-1; D000804:Angiotensin II; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases