Effects of 8-OH-DPAT, a 5-HT1A receptor agonist, and DOI, a 5-HT2A/2C agonist, on monosynaptic transmission in spinalized rats.
We investigated the effect of 5-HT1A receptor agonist (-/+)-8-hydroxy-2-(di-N-propylamino)tetraline (8-OH-DPAT) and the 5-HT2A/2C receptor agonist (-/+)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on monosynaptic transmission in spinalized rats. 8-OH-DPAT significantly inhibited the excitation of alpha-motoneurons evoked by monosynaptic transmission without a direct effect on alpha-motoneuron excitation. DOI potentiated the excitation of alpha-motoneurons by both direct stimulation and monosynaptic transmission. These results indicate that activation of 5-HT1A receptors inhibits monosynaptic transmission, whereas activation of 5-HT2A/2C receptors enhances it.
Hasegawa
Y
Y
Department of Pharmacy, Branch Hospital, Faculty of Medicine, University of Tokyo, Japan. myutaka@hongo.ecc.u-tokyo.ac.jp
Ono
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H
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D003655:Decerebrate State; D004305:Dose-Response Relationship, Drug; D008297:Male; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012023:Reflex, Monosynaptic / Q000187:drug effects; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects*
D000662:Amphetamines; D017366:Serotonin Receptor Agonists; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; C015952:4-iodo-2,5-dimethoxyphenylisopropylamine