title: [The effect of the physico-chemical properties of suture materials and the surface structure on adherence of tumor cells].
abstract: Local recurrence following curative resection for colorectal cancer may be caused by the seeding of free malignant cells at the anastigmatic site. This study investigated the influence of suture material on in vitro tumor cell adherence. Radiolabeled rat colonic cancer cells (RCC5) were incubated with a variety of suture materials, and the relative contribution of chemical composition and physical configuration to cell adherence was assessed. Nonadherent cells were washed free, and the cell adherence was determined by radioactive counting. Marked differences in adherence were observed, with cells preferentially adhering to protein-based and multifilament sutures. These observations were confirmed using scanning electron microscopy. These findings indicate that both chemical composition and physical configuration influence the adherence of tumor cells to sutures and suggest that the use of protein-based and multifilament sutures be carefully considered in situations where free malignant cells may be present following colorectal surgery.
authors.affiliation: Professorial Surgical Unit, St. Bartholmew's Hospital, London, United Kingdom.
authors.forename: C R
authors.initials: CR
authors.lastname: Uff
authors.forename: C Y
authors.initials: CY
authors.lastname: Yiu
authors.forename: P B
authors.initials: PB
authors.lastname: Boulos
authors.forename: R K
authors.initials: RK
authors.lastname: Phillips
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D003110:Colonic Neoplasms / Q000473:pathology*; D051381:Rats; D011916:Rats, Inbred F344; D013499:Surface Properties; D013537:Sutures; D014407:Tumor Cells, Cultured / Q000473:pathology
vernacular_title: Vliv fyzikálnĕ-chemických vlastností sicího materiálu a jeho povrchové struktury na adherenci nádorových bunĕk.