Eremomastax speciosa: effects of leaf aqueous extract on ulcer formation and gastric secretion in rats.
The anti-ulcerogenic potential of the aqueous extract of Eremomastax speciosa leaves was investigated using two methods of ulcer induction: HCl/EtOH-induced ulceration and pylorus ligation. With both methods, the extract inhibited gastric ulceration in a dose-related manner. The highest oral dose tested (190 mg/kg) completely inhibited gastric ulceration and significantly reduced gastric acidity compared with the controls. Incubation of gastric juice with the plant extract (190 mg/kg) significantly reduced the acidity of the incubated gastric juice compared with the controls.
Tan
P V
PV
Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, Cameroon.
Nditafon
N G
NG
Yewah
M P
MP
Dimo
T
T
Ayafor
F J
FJ
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
D000897:Anti-Ulcer Agents