title: Anomalies in hepatobiliary excretion of technetium-99m-MAG3 preparations.
abstract: Technetium-99m-MAG3 is accepted as a renal tubular function agent. However, sporadic liver and gall bladder visualisation during its clinical use is clearly a disadvantage. HPLC-purified 99mTc-MAG3 samples exhibited appreciable hepatobiliary uptake (7%), and an elevated level of such uptake was observed in unpurified kit preparations, which was stated to be associated with the excretory property of the radiolabeled kit impurities. To verify this we attempted to quantitate the hepatobiliary uptake of the kit preparations with that of its radiolabeled components. The contribution of each component toward hepatobiliary uptake of the sample was calculated from their abundance in the chelate mixture and the individual biodistribution of the isolated components. However, the anticipated hepatobiliary uptake of different preparations of 99mTc-MAG3 calculated in this way was always lower than that of the experimental value determined directly. Further work is needed to explain the anomaly.
authors.affiliation: Indian Institute of Chemical Biology, Calcutta, India.
authors.forename: M
authors.initials: M
authors.lastname: Chatterjee
authors.forename: A
authors.initials: A
authors.lastname: Majumder
authors.forename: P
authors.initials: P
authors.lastname: Iyer
authors.forename: G
authors.initials: G
authors.lastname: Muthukrishnan
authors.forename: M K
authors.initials: MK
authors.lastname: Das
authors.forename: N
authors.initials: N
authors.lastname: Ramamoorthy
authors.forename: C N
authors.initials: CN
authors.lastname: Desai
authors.forename: S
authors.initials: S
authors.lastname: Banerjee
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004227:Dithionite; D005704:Gallbladder / Q000000981:diagnostic imaging / Q000378:metabolism*; D007202:Indicators and Reagents; D007413:Intestinal Mucosa / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism*; D011877:Radionuclide Imaging; D051381:Rats; D017207:Rats, Sprague-Dawley; D017263:Technetium Tc 99m Mertiatide / Q000138:chemical synthesis / Q000302:isolation & purification / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D007202:Indicators and Reagents; D004227:Dithionite; D017263:Technetium Tc 99m Mertiatide