[The interaction of the renin-angiotensin and enkephalinergic systems of the brain and hypophysis in normal rats and in experimental pathology of the hypothalamo-hypophyseal-adrenal complex].
Administration of angiotensin-converting enzyme inhibitor captopril inhibited the activity of renin-angiotensin system (RAS), increased leukin-enkephalin level in the hypothalamus and adenohypophysis. The data obtained suggest that the enzyme is an important link in the mechanism of interaction between the renin-angiotensin and enkephalinergic systems in rats.
Kalinskaia
L N
LN
Kononenko
V Ia
VIa
D000315:Adrenalectomy; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology; D002216:Captopril / Q000494:pharmacology; D004743:Enkephalin, Leucine / Q000032:analysis / Q000187:drug effects; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives / Q000494:pharmacology; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000502:physiology*; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects / Q000502:physiology*; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D000806:Angiotensin-Converting Enzyme Inhibitors; D011957:Receptors, Opioid; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; D002216:Captopril; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Vzaimodeĭstvie renin-angiotenzinovoĭ i énkefalinergicheskoĭ sistem mozga i gipofiza krys v norme i pri éksperimental'noĭ patologii gipotalamo-gipofizarno-nadpochechnikovogo kompleksa.