title: Neuroprotective effect of 4'-(4-methylphenyl)-2,2':6',2-terpyridine trihydrochloride, a novel inducer of nerve growth factor.
abstract: We have identified 4'-(4-methylphenyl)-2,2':6',2-terpyridine: trihydrochloride (SS701), which belongs to a family of a small unique neuroprotective agents. SS701 accelerated the production of nerve growth factor (NGF) in cultured astroglial cells, dose- and time-dependently. In in vivo studies, SS701, when administered 30 min after induced cerebral ischemia, neuroprotective effects on delayed neuronal death in Mongolian gerbils were evident. The neuroprotective effects of SS701 against ischemia-induced delayed neuronal death are attributed to stimulation of the production of NGF.
authors.affiliation: 1st Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: R
authors.initials: R
authors.lastname: Yoshikawa
authors.forename: S
authors.initials: S
authors.lastname: Okuyama
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Karasawa
authors.forename: N
authors.initials: N
authors.lastname: Hino
authors.forename: T
authors.initials: T
authors.lastname: Miyoshi
authors.forename: H
authors.initials: H
authors.lastname: Araki
authors.forename: K
authors.initials: K
authors.lastname: Hanabusa
authors.forename: H
authors.initials: H
authors.lastname: Shirai
authors.forename: K
authors.initials: K
authors.lastname: Tomisawa
mesh_terms: D015082:2,2'-Dipyridyl / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001157:Arterial Occlusive Diseases / Q000473:pathology; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism; D016923:Cell Death; D002478:Cells, Cultured; D005260:Female; D005849:Gerbillinae; D051379:Mice; D008813:Mice, Inbred ICR; D009414:Nerve Growth Factors / Q000096:biosynthesis*; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology*; D011247:Pregnancy
chemical_list: D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; D015082:2,2'-Dipyridyl; C102502:4'-(4-methylphenyl)-2,2'-6',2''-terpyridine