Somatic in vivo alterations of the JV18-1 gene at 18q21 in human lung cancers.
The chromosome region 18q21 is frequently deleted in lung cancers. Recent identification of JV18-1 at this locus led us to examine whether or not it might also be altered in lung cancers, as is the case for the closely related DPC4 tumor suppressor gene. A missense somatic mutation and a 9-bp in-frame deletion were detected in the highly conserved region of JV18-1 among 57 lung cancer specimens taken directly from patients. The total alterations in JV18-1 and DPC4, however, are not sufficient to account for all 18q21 deletions in lung cancers. These findings suggest that although JV18-1 and DPC4 may play roles in a limited fraction of lung cancers, another tumor suppressor gene may also exist in this chromosome region.
Uchida
K
K
Laboratory of Ultrastructure Research, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, Japan.
Nagatake
M
M
Osada
H
H
Yatabe
Y
Y
Kondo
M
M
Mitsudomi
T
T
Masuda
A
A
Takahashi
T
T
Takahashi
T
T
D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics; D018288:Carcinoma, Small Cell / Q000235:genetics; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D017353:Gene Deletion; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics*; D051899:Smad2 Protein; D015534:Trans-Activators
D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; C497782:SMAD2 protein, human; D051899:Smad2 Protein; D015534:Trans-Activators