title: The neutron therapy clinical programme at the National Accelerator Centre (NAC).
abstract: A total of 721 patients were treated in the neutron therapy programme at NAC from February 1989-March 1995 with a p(66)/Be isocentric unit. The preliminary results showed: 3-year local control and survival probabilities of 57 and 79% respectively for advanced salivary gland tumours; increased local control for twice-daily neutron therapy for advanced head and neck cancer compared with photon therapy; local control rates of 68 and 83% for locally advanced breast cancer treated with 17 and 19 Gy respectively; complete response rates of 67% for macroscopic residual soft tissue sarcomas and those with irresectable disease of less than 10 cm; complete response rate of 56% for macroscopic residual uterine sarcoma with a median follow up of 38 months; 2-year local control rate and survival of 44 and 38% respectively for advanced squamous carcinoma of the maxillary antrum; complete response rate of 38% for advanced osteosarcomas and chondrosarcomas.
authors.affiliation: Department of Radiation Oncology, University of Cape Town, South Africa.
authors.forename: C E
authors.initials: CE
authors.lastname: Stannard
authors.forename: F J
authors.initials: FJ
authors.lastname: Vernimmen
authors.forename: D T
authors.initials: DT
authors.lastname: Jones
authors.forename: A L
authors.initials: AL
authors.lastname: Van Wijk
authors.forename: S M
authors.initials: SM
authors.lastname: Brennan
authors.forename: A M
authors.initials: AM
authors.lastname: Visser
authors.forename: C A
authors.initials: CA
authors.lastname: Johnson
authors.forename: J A
authors.initials: JA
authors.lastname: Wilson
authors.forename: E A
authors.initials: EA
authors.lastname: Murray
authors.forename: C V
authors.initials: CV
authors.lastname: Levin
authors.forename: E E
authors.initials: EE
authors.lastname: Mills
authors.forename: A
authors.initials: A
authors.lastname: Alberts
authors.forename: I D
authors.initials: ID
authors.lastname: Werner
authors.forename: B J
authors.initials: BJ
authors.lastname: Smit
authors.forename: G
authors.initials: G
authors.lastname: Schmitt
mesh_terms: D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy; D018567:Breast Neoplasms, Male / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D009369:Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D009502:Neutrons; D016730:Program Development; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy / Q000379:methods*; D012509:Sarcoma / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy; D016019:Survival Analysis; D014594:Uterine Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy