title: Role of the locus coeruleus in the sleep rebound following two different sleep deprivation methods in the rat.
abstract: The aim of the present study was to assess the involvement of the locus coeruleus in the paradoxical sleep rebound following sleep deprivation in the rat. Animals were sleep-deprived for 10 h before, and after, specific N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) lesioning of the noradrenergic-locus coeruleus system. Sleep deprivation was produced using either an instrumental (water tank) or pharmacological (methylamphetamine) method. After lesioning, the rats submitted to the instrumental method showed a significant decrease in the paradoxical and slow-wave sleep rebounds (-54% and -78%, respectively), while animals receiving metamphetamine did not. Our results suggest that the noradrenergic system of the locus coeruleus is a relevant component of the sleep rebound mechanisms. However, the extent of involvement is dependent on the sleep deprivation method used.
authors.affiliation: Départment de Médecine Expérimentale, INSERM U52, CNRS URA1195, Faculté de Médecine, Université Claude Bernard, Lyon, France.
authors.forename: M M
authors.initials: MM
authors.lastname: González
authors.forename: J L
authors.initials: JL
authors.lastname: Valatx
authors.forename: G
authors.initials: G
authors.lastname: Debilly
mesh_terms: D018663:Adrenergic Agents / Q000494:pharmacology*; D000818:Animals; D001596:Benzylamines / Q000494:pharmacology*; D007150:Immunohistochemistry; D008125:Locus Coeruleus / Q000502:physiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation / Q000502:physiology*
chemical_list: D018663:Adrenergic Agents; D001596:Benzylamines; C012102:DSP 4