The staurosporine producing strain Streptomyces longisporoflavus produces metabolites related to K-252a. Proposal for biosynthetic intermediates of K-252a.
Cai
Y
Y
Core Drug Discovery Technologies, CIBA-GEIGY Ltd., Basel, Switzerland.
Fredenhagen
A
A
Hug
P
P
Peter
H H
HH
D000818:Animals; D002227:Carbazoles / Q000737:chemistry / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D026121:Indole Alkaloids; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D019311:Staurosporine / Q000096:biosynthesis*; D013302:Streptomyces / Q000378:metabolism*; D013552:Swine
D002227:Carbazoles; D004791:Enzyme Inhibitors; D026121:Indole Alkaloids; C049985:staurosporine aglycone; D011493:Protein Kinase C; D019311:Staurosporine