title: Localization of Cu/Zn-SOD and Mn-SOD in the rat cochlea.
abstract: Distributions of the copper/zinc-superoxide dismutase (Cu/Zn-SOD) and the manganese superoxide dismutase (Mn-SOD) in the rat cochlea were studied by immunohistochemistry with specific polyclonal antibodies to Mn-SOD and Cu/Zn-SOD. Coexpression of Mn-SOD and Cu/Zn-SOD was observed in the cochlear tissues with differing immunoactivity intensities. The presence of Cu/Zn- and Mn-SOD implies the existence of a defense system against free oxygen radical (FOR) injury in cochlear tissues.
authors.affiliation: Department of Anatomy & Cell Biology, College of Medicine, University of Florida, Gainesville 32610, USA.
authors.forename: K E
authors.initials: KE
authors.lastname: Rarey
authors.forename: X
authors.initials: X
authors.lastname: Yao
mesh_terms: D000818:Animals; D003051:Cochlea / Q000378:metabolism / Q000648:ultrastructure*; D005609:Free Radicals; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism / Q000648:ultrastructure*
chemical_list: D005609:Free Radicals; D013482:Superoxide Dismutase