title: Development of acromegaly during treatment of hyperprolactinemia with bromocriptine: an unusual acidophil stem cell adenoma.
abstract: We present clinical details of a patient with a 20-yr history of amennorhea, a pituitary tumor, elevated PRL levels, and initially undetectable GH. Bromocriptine failed to fully suppress PRL, and there was no tumor shrinkage. Within 7 months of starting bromocriptine treatment, the patient developed clinical and biochemical signs of acromegaly. At surgery, a stem cell adenoma was excised. The mechanisms by which bromocriptine may have resulted in the development of acromegaly in this patient are discussed.
authors.affiliation: Department of Endocrinology, General Infirmary, Leeds, United Kingdom.
authors.forename: M D
authors.initials: MD
authors.lastname: Page
authors.forename: L R
authors.initials: LR
authors.lastname: Bridges
authors.forename: J H
authors.initials: JH
authors.lastname: Barth
authors.forename: A M
authors.initials: AM
authors.lastname: McNichol
authors.forename: P E
authors.initials: PE
authors.lastname: Belchetz
mesh_terms: D000172:Acromegaly / Q000209:etiology*; D000239:Adenoma, Acidophil / Q000209:etiology*; D000328:Adult; D001971:Bromocriptine / Q000009:adverse effects*; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006727:Hormone Antagonists / Q000009:adverse effects*; D006801:Humans; D006966:Hyperprolactinemia / Q000188:drug therapy*; D010911:Pituitary Neoplasms / Q000209:etiology*
chemical_list: D006727:Hormone Antagonists; D001971:Bromocriptine; D013006:Growth Hormone