title: Administration of propofol by target-controlled infusion in patients undergoing coronary artery surgery.
abstract: OBJECTIVE
  To study the predictive performance of a target-controlled infusion (TCI) system of propofol in patients undergoing coronary bypass graft (CABG) surgery, using a referenced pharmacokinetic set derived from healthy patients. Also, to determine the propofol concentrations required for clinically acceptable induction and maintenance of anesthesia when combined with midazolam as premedication and a continuous alfentanil infusion and to study the hemodynamic stability of this technique.
  
  
  METHODS
  Prospective noncomparative study analysis.
  
  
  METHODS
  Operating room at a university hospital.
  
  
  METHODS
  Twenty-on patients with good left ventricular function undergoing coronary artery surgery.
  
  
  METHODS
  Patients were anesthetized using a continuous infusion of alfentanil (mean infusion rate: 1 microgram/kg/min) and propofol administered by TCI.
  
  
  RESULTS
  The predictive performance of the TCI system (212 arterial samples) was measured at specified time points before, during, and after bypass. The TCI system underestimated the measured blood propofol concentrations with a bias of +21.2% and +9.6% during the prebypass and the bypass periods, respectively. The predictive inaccuracy, expressed by the median absolute prediction error, was 23% and 18.5%, respectively. Mean target propofol concentrations required to induce and maintain anesthesia before bypass were 0.92 microgram/mL and 3.64 micrograms/mL, respectively. In the period during and after bypass, the mean target concentrations required to maintain anesthesia was 2.22 micrograms/mL. The administration of propofol by TCI was still associated with some short episodes of hemodynamic instability that were easily controlled by adjusting the target concentration in the majority of the patients. Therefore, the overall quality and ease of control of anesthesia were considered as being good or adequate.
  
  
  CONCLUSIONS
  In this group of patients undergoing CABG surgery, the TCI system used underestimated the measured propofol concentrations. However, the predictive performance of the selected mean pharmacokinetic parameters derived from healthy patients was acceptable during the whole surgical procedure.
authors.affiliation: Department of Anesthesiology, Erasmus Hospital, Free University of Brussels, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Barvais
authors.forename: I
authors.initials: I
authors.lastname: Rausin
authors.forename: J B
authors.initials: JB
authors.lastname: Glen
authors.forename: S C
authors.initials: SC
authors.lastname: Hunter
authors.forename: D
authors.initials: D
authors.lastname: D'Hulster
authors.forename: F
authors.initials: F
authors.lastname: Cantraine
authors.forename: A
authors.initials: A
authors.lastname: d'Hollander
mesh_terms: D000328:Adult; D000368:Aged; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D001026:Coronary Artery Bypass; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage*; D011446:Prospective Studies
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol