[Treatment of neonatal hyperthyroidism with calcium iopodate].
BACKGROUND
Treatment of hyperthyroidism in those neonates born to mothers with Grave's disease is difficult. Calcium ipodate, an agent for oral cholecystography, inhibits extra-thyroid conversion of T3 to T4 and diminishes thyroid secretion.


METHODS
Two neonates with clinical manifestations and biological findings of hyperthyroidism were given calcium ipodate orally, 400 mg every 3 days, from day 26 to 50 for the first patient and from day 9 to 18 for the second in association with a beta blocker. Clinical manifestations disappeared within 2 days and circulating levels of T3 and T4 were normalized within 2-5 days.


CONCLUSIONS
This treatment was effective and well-tolerated in both patients and in three others previously reported; it should be confirmed in a larger number of patients and controlled by measuring levels of antibodies directed against thyrotropin-releasing hormone receptors in order to avoid relapse after cessation of treatment as seen in our second patient.
Mariani
R
R
Service de pédiatrie, hôpital de Cimiez, Nice, France.
Bertrand
A M
AM
Maillotte
A M
AM
Peyrade
C
C
Bortoluzzi
M N
MN
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy*; D007231:Infant, Newborn; D007487:Ipodate / Q000008:administration & dosage / Q000627:therapeutic use*; D011433:Propranolol; D014284:Triiodothyronine / Q000037:antagonists & inhibitors*
D000319:Adrenergic beta-Antagonists; D014284:Triiodothyronine; D011433:Propranolol; D007487:Ipodate
Traitement de l'hyperthyroïdie néonatale par l'iopodate de calcium.