Gadolinium(III) di- and tetrachelates designed for in vivo noncovalent complexation with plasma proteins: a novel molecular design for blood pool MRI contrast enhancing agents.
A new series of gadolinium chelates designed as blood pool contrast enhancing agents for magnetic resonance imaging applications is described. Complexes having four Gd(III) chelate units display a significant increase in molecular relaxivity per gadolinium ion in water (9-13 L x mmol(-1) x (s-1) compared to Gd(III)-DTPA (5 L x mmol(-1) x s(-1). A further jump in relaxivity (25 L x mmol(-1) x sec(-1) in 4% BSA solution was observed in the case of a fatty acid-containing tetrachelate and is attributed to noncovalent binding of the tetrachelate to serum albumin. This agent was successfully used for imaging the rat circulatory system.
Martin
V V
VV
Department of Chemistry, University of Oregon, Eugene 97403, USA.
Ralston
W H
WH
Hynes
M R
MR
Keana
J F
JF
D000818:Animals; D001798:Blood Proteins / Q000737:chemistry*; D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry*; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry; D015195:Drug Design; D005682:Gadolinium / Q000737:chemistry*; D019786:Gadolinium DTPA; D015637:Gated Blood-Pool Imaging / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D004369:Pentetic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012709:Serum Albumin / Q000737:chemistry
D001798:Blood Proteins; D002614:Chelating Agents; D003287:Contrast Media; D009942:Organometallic Compounds; D012709:Serum Albumin; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA