title: [Amiodarone-induced pulmonary fibrosis].
abstract: The most feared side-effect of long-term amiodarone therapy is progressive alveolitis/pneumonitis leading to pulmonary fibrosis. The case history of a patient is presented who received amiodarone unnecessarily in a high dose (600 mg/day) for 4 years: drug-induced dermatopathy, hypothyroidism and lung fibrosis developed. After cessation of amiodarone treatment the pulmonary complication did not disappear therefore glucocorticoid therapy was introduced. New-onset improductive cough, dyspnea, fever and/or enhanced erythrocyte sedimentation rate may suggest the presence of amiodarone pulmonary toxicity and may form the basis of indication of high-resolution computed tomography (HRCT). Amiodarone-induced pulmonary involvement can be shown by HRCT early, before the appearance of any considerable abnormality of chest radiography.
authors.affiliation: Szent-Györgyi Albert Orvostudományi Egyetem, Szeged.
authors.forename: C
authors.initials: C
authors.lastname: Lengyel
authors.forename: I
authors.initials: I
authors.lastname: Boros
authors.forename: T
authors.initials: T
authors.lastname: Várkonyi
authors.forename: A
authors.initials: A
authors.lastname: Selmeczi
authors.forename: T
authors.initials: T
authors.lastname: Fazekas
mesh_terms: D000638:Amiodarone / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed
chemical_list: D000638:Amiodarone
vernacular_title: Amiodaron által elöidézett tüdöfibrosis.