title: Cytogenetic analysis of a case of myxoid liposarcoma with cartilaginous differentiation.
abstract: The cytogenetic analysis of a patient with a myxoid liposarcoma exhibiting cartilaginous differentiation is presented. A complex translocation involving chromosome 12, 16, and 19 was found, instead of the t(12;16), specific for myxoid liposarcoma. The involvement of 19q13 in a tumor with cartilaginous differentiation, and the assignment of TGF beta 1 to 19q13.1-13.2, which appears to play a role in the formation of bone and cartilage, suggest a possible relation between both.
authors.affiliation: Department of Medical Genetics, Groningen University, The Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: Dijkhuizen
authors.forename: W M
authors.initials: WM
authors.lastname: Molenaar
authors.forename: H J
authors.initials: HJ
authors.lastname: Hoekstra
authors.forename: J
authors.initials: J
authors.lastname: Wiersema
authors.forename: E
authors.initials: E
authors.lastname: van den Berg
mesh_terms: D000328:Adult; D002356:Cartilage / Q000473:pathology; D002454:Cell Differentiation; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D002885:Chromosomes, Human, Pair 16; D002888:Chromosomes, Human, Pair 19; D006801:Humans; D007621:Karyotyping; D018208:Liposarcoma, Myxoid / Q000235:genetics* / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D008297:Male; D011879:Radiotherapy Dosage; D016212:Transforming Growth Factor beta / Q000235:genetics; D014178:Translocation, Genetic
chemical_list: D016212:Transforming Growth Factor beta