title: [Use of immunomocorrection in the combined treatment of laryngeal papillomatosis in children].
abstract: Original immunological studies allowed the authors to design a combined treatment of laryngeal papillomatosis (LP) with administration of immunomodulators and cytostatics. Surgery was performed on demand. Thymic hormone preparation (T-activin, thymalin, thymogen) and prospidin served as immunomodulators and cytostatic, respectively. To create lymphotropism, prospidin was delivered by means of electrophoresis following subcutaneous introduction of 8--16 U lidase. Sensitivity of patients to thymalin was tested in vitro by thymalin-induced changes in the number of CD2--DR+ lymphocytes. Adjuvant modalities were age-adjusted dibasol as inductor of interferon genesis and adaptogens (eleutherococcal fluid extract, B and C vitamins). Such treatment was given to 39 children. Remission duration increased 1.6--2.6-fold, 6 of 7 children with primary LP achieved persistent remission. Positive changes in immunological indices occurred in 84% of children. The above treatment outcomes support the efficacy of the method in childhood LP.
authors.forename: I V
authors.initials: IV
authors.lastname: Savenko
authors.forename: E A
authors.initials: EA
authors.lastname: Tsvetkov
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004151:Dipeptides; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000627:therapeutic use; D007223:Infant; D007369:Interferon Inducers / Q000627:therapeutic use*; D007822:Laryngeal Neoplasms / Q000188:drug therapy*; D010212:Papilloma / Q000188:drug therapy*; D010455:Peptides / Q000627:therapeutic use; D011447:Prospidium / Q000627:therapeutic use*; D013949:Thymus Extracts / Q000627:therapeutic use
chemical_list: D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D001562:Benzimidazoles; D004151:Dipeptides; D007369:Interferon Inducers; D010455:Peptides; D013949:Thymus Extracts; C060736:thymogen; C004453:bendazole; D011447:Prospidium; C036191:T-activin; C001543:lidase; D006821:Hyaluronoglucosaminidase
vernacular_title: Ispol'zovanie sredstv immunokorrektsii v kompleksnom lechenii papillomatoza gortani u deteĭ.