Cell-cell interactions and segmentation in the developing vertebrate hindbrain.
During development of the vertebrate hindbrain, regulatory gene expression becomes precisely restricted to specific segments. Studies at the cellular and molecular levels suggest that establishment of this precise pattern of gene expression may involve a dynamic regulation of cell identity and a restriction of cell movement across rhombomere boundaries. Candidates for mediating such interactions are several members of the Eph-related receptor tyrosine kinase (RTK) family that have segmental expression in the hindbrain. Ligands for members of this RTK family are membrane-bound, and may therefore mediate cell contact-dependent signalling. We discuss the expression patterns of Eph-related receptors in the hindbrain and the potential roles that these may play in patterning.
Irving
C
C
Laboratory of Developmental Neurobiology, National Institute for Medical Research, London, U.K.
Flenniken
A
A
Alldus
G
G
Wilkinson
D G
DG
D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D002642:Chick Embryo; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology; D012249:Rhombencephalon / Q000254:growth & development*
D020794:Receptor Protein-Tyrosine Kinases