title: [Some mechanisms of pathogenesis of hypertonic type neurocirculatory dystonia in flying personnel].
abstract: Cytochemical analysis was used to compare the activities of hyaloplasmatic and mitochondrial glycerophosphate dehydrogenase, and succinate dehydrogenase in lymphocytes of peripheral blood taken from 14 aviators with the diagnose of hypertonic neurocirculatory dystonia, and 18 healthy aviators. Significantly higher activity of these enzymes in patients is assumed to signify intensification of metabolism and cellular respiration bearing the forced adaptive character. On this evidence, an attempt is made to interpret earlier discovered changes in the immunobiochemical status of these patients and plausible mechanisms of progressive arterial hypertension are hypothesized. Emphasis is laid on the necessity to direct secondary preventive measures at the early phases of hypertension not only on reduction of the vascular tone and correction of the immunobiochemical status but on building-up of cell's functional reserves.
authors.affiliation: State Research Experimental Institute of Aircraft and Space Medicine, Department of Defence, Russian Federation.
authors.forename: S L
authors.initials: SL
authors.lastname: Denisov
authors.forename: L V
authors.initials: LV
authors.lastname: Koroleva
authors.forename: I A
authors.initials: IA
authors.lastname: Lairov
mesh_terms: D000337:Aerospace Medicine; D004924:Escape Reaction; D005993:Glycerolphosphate Dehydrogenase / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000276:immunology; D008214:Lymphocytes / Q000201:enzymology*; D013385:Succinate Dehydrogenase / Q000097:blood*
chemical_list: D005993:Glycerolphosphate Dehydrogenase; D013385:Succinate Dehydrogenase
vernacular_title: Nekotorye mekhanismy patogenesa neirotsirkuliatornoi distonii gipertonicheskogo tipa u letnogo sostava.