title: Superiority of C-11 acetate compared with F-18 fluorodeoxyglucose in predicting myocardial functional recovery by positron emission tomography in patients with acute myocardial infarction.
abstract: In patients with chronic coronary artery disease, preservation of myocardial oxidative metabolism measured by positron emission tomography (PET) with 11C-acetate is a more accurate predictor of subsequent myocardial functional recovery than is maintenance of glucose metabolism estimated with 18F-fluorodeoxyglucose. However, whether measurements of myocardial oxidative metabolism are more accurate than measurements of glucose metabolism in predicting functional recovery in patients with recent myocardial infarction is unknown. Myocardial oxidative metabolism was measured within 10 days of infarction in 19 patients by analysis of the rate of myocardial clearance of 11C-acetate. Metabolism of glucose was assessed by analysis of the uptake of 18F-fluorodeoxyglucose. Criteria for prediction of the recovery of function based on measurements of oxidative metabolism and glucose metabolism were compared. Threshold criteria with 11C-acetate exhibited superior positive and negative predictive values (89% and 73%, respectively) compared with the criteria of 18F-fluorodeoxyglucose (65% and 57%, respectively) (p <0.025). In addition, the magnitude of functional recovery after revascularization correlated with the severity of the metabolic abnormality present initially. In patients with recent myocardial infarction, the extent of functional recovery can be predicted accurately by measurement of regional oxidative metabolism by PET with 11C-acetate, and these measurements are superior to those of 18-fluorodeoxyglucose.
authors.affiliation: Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Rubin
authors.forename: D S
authors.initials: DS
authors.lastname: Lee
authors.forename: V G
authors.initials: VG
authors.lastname: Dávila-Román
authors.forename: E M
authors.initials: EM
authors.lastname: Geltman
authors.forename: K B
authors.initials: KB
authors.lastname: Schechtman
authors.forename: S R
authors.initials: SR
authors.lastname: Bergmann
authors.forename: R J
authors.initials: RJ
authors.lastname: Gropler
mesh_terms: D000085:Acetates / Q000493:pharmacokinetics*; D000328:Adult; D000368:Aged; D002250:Carbon Radioisotopes; D002908:Chronic Disease; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005260:Female; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics*; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption; D011237:Predictive Value of Tests; D013599:Systole / Q000502:physiology; D014055:Tomography, Emission-Computed; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D000085:Acetates; D002250:Carbon Radioisotopes; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; D005947:Glucose