Erythrocyte Li-Na countertransport in uremic patients: effect of urea.
Abnormalities of erythrocyte cation transport systems including Li-Na countertransport have been described in uremic patients. Dialysis appears to eliminate the difference in some of the patients. We investigated the rate of Li-Na countertransport from erythrocytes of normal healthy subjects and uremic patients undergoing hemodialysis treatment. We found that erythrocytes from uremic patients exhibited a significantly elevated rate of Li-Na countertransport. Furthermore, urea (30 mM) did not affect the rate of Li-Na countertransport or the electrolyte contents for Li loaded erythrocytes. Our findings showed that while both plasma and urea concentration and erythrocyte Li-Na countertransport were elevated in uremic patients, urea was not the major cause of the enhanced activity of the transporter.
Sun
Y F
YF
Foo Yin Junior College of Nursing and Medical Technology, Kaohsiung, R.O.C.
Tsai
C J
CJ
Hsieh
C C
CC
Lau
Y T
YT
D000328:Adult; D017920:Antiporters / Q000378:metabolism*; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D012016:Reference Values; D006435:Renal Dialysis; D014508:Urea / Q000494:pharmacology*; D014511:Uremia / Q000097:blood* / Q000628:therapy
D017920:Antiporters; C045885:sodium-lithium countertransporter; D014508:Urea