Determination of beta-blocker drugs in pharmaceutical preparations by non-suppressed ion chromatography.
A rapid and feasible chromatographic method for determining atenolol, metoprolol, alprenolol, oxprenolol, acebutolol and propranolol by non-suppressed ion chromatography is proposed. The mobile phase consisted of 50 mM nitric acid in an aqueous solution of 4% (v/v) acetonitrile. Detection limits are in the range 0.1-2.7 mg l-1. The method was successfully applied to the determination of beta-blockers in several pharmaceutical formulations.
Ghanem
R
R
Department of Analytical Chemistry, Faculty of Chemistry, University of Seville, Spain.
Bello
M A
MA
Callejón
M
M
Guiraúm
A
A
D000319:Adrenergic beta-Antagonists / Q000032:analysis* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002845:Chromatography / Q000379:methods; D015203:Reproducibility of Results
D000319:Adrenergic beta-Antagonists