Inflammation of solar keratoses following systemic 5-fluorouracil.
Several cutaneous reactions have been reported following systemic 5-fluorouracil (5-FU) for the treatment of malignancies. We report three patients with marked inflammation of the solar keratoses following continuous infusion of 5-FU for solid tumours. This side-effect with 5-FU, only previously reported in three other cases, was beneficial as most solar keratoses cleared following the inflammatory reaction. The reasons why 5-FU should be selectively taken up by solar keratoses are discussed.
Bataille
V
V
Dermatology Department, St George's Hospital, London, U.K.
Cunningham
D
D
Mansi
J
J
Mortimer
P
P
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D004890:Erythema / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D007642:Keratosis / Q000139:chemically induced* / Q000473:pathology; D008297:Male
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil