title: [The reversible inhibition of cholinesterases from different biological sources by phosphonium betaines].
abstract: The action of some phosphonium betains on cholinesterases from different biological sources has been studied. It has been shown, that all studied betains are reversible inhibitors of cholinesterase hydrolysis of acetyltiocholine. Inhibiting action of these compounds on acetylcholinesterases is about ten times weaker that of the majority of known phosphonium salts, while their action on butyrylcholinesterases has no peculiarities. There were found certain differences for each betain compounds in their action on cholinesterases from different biological sources. These results may be used for detail classification of cholinesterases and allow to extend knowledge in comparative enzymology.
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Zhuzhovskiĭ
authors.forename: L P
authors.initials: LP
authors.lastname: Kuznetsova
authors.forename: E E
authors.initials: EE
authors.lastname: Sochilina
authors.forename: E N
authors.initials: EN
authors.lastname: Dmitrieva
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Gololobov
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Bykovskaia
mesh_terms: D000818:Animals; D001622:Betaine / Q000031:analogs & derivatives*; D002384:Catalysis / Q000187:drug effects; D002417:Cattle; D002645:Chickens; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D002802:Cholinesterases / Q000187:drug effects*; D010856:Columbidae; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology; D005399:Fishes; D006736:Horses; D006801:Humans; D008297:Male; D013053:Spectrophotometry; D013997:Time Factors
chemical_list: D002800:Cholinesterase Inhibitors; D001622:Betaine; D002802:Cholinesterases
vernacular_title: Obratimoe ugnetenie kholinésteraz iz rachlichnykh biologicheskikh istochnikov fosfonievymi betainami.