title: Influence of magnesium deficiency on concentration of calcium in soft tissue of uremic rats.
abstract: The influence of magnesium (Mg) deficiency on the concentration of calcium (Ca) in the aorta, heart, and kidney was evaluated in uremic rats. A total of 32 rats were randomly assigned to two groups: one group made uremic by the 5/6 nephrectomy method, and the other serving as sham-operated controls. Both groups were randomly assigned to two subgroups: one group given a Mg-deficient diet and the other fed a Mg-supplemented diet. After 12 weeks on the regimen, all animals were sacrificed. In Mg-supplemented uremic rats, the concentration of Ca in the aorta was higher than in Mg-supplemented control rats. The concentration of Ca in the aorta was further increased in Mg-deficient uremic rats. The concentrations of Ca in the heart and the kidney were also increased in Mg-deficient uremic rats, as compared with Mg-supplemented uremic rats. The concentration of Mg was decreased in the aorta and increased in the kidney of Mg-deficient rats. There was no significant influence of Mg deficiency on the concentration of phosphate in tissue. Results suggest that Mg deficiency in uremia may increase aortic calcification.
authors.affiliation: Department of Kidney and Dialysis, Hyogo College of Medicine, Japan.
authors.forename: O
authors.initials: O
authors.lastname: Inagaki
authors.forename: T
authors.initials: T
authors.lastname: Syono
authors.forename: K
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Nishian
authors.forename: Y
authors.initials: Y
authors.lastname: Takenaka
authors.forename: Y
authors.initials: Y
authors.lastname: Takamitsu
mesh_terms: D000818:Animals; D002114:Calcinosis / Q000209:etiology* / Q000503:physiopathology; D002118:Calcium / Q000032:analysis* / Q000097:blood; D046508:Culture Techniques; D004032:Diet; D004195:Disease Models, Animal; D008274:Magnesium / Q000032:analysis* / Q000097:blood; D008275:Magnesium Deficiency / Q000150:complications*; D008297:Male; D010710:Phosphates / Q000032:analysis* / Q000097:blood; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D014511:Uremia
chemical_list: D010710:Phosphates; D008274:Magnesium; D002118:Calcium