title: MRI of microadenomas in patients with hyperprolactinaemia.
abstract: MRI is a sensitive tool for the investigation of pituitary microadenomas but cannot be used as a screening investigation. To establish a strategy for the use of MRI in patients with hyperprolactinaemia we investigated 74 women with serum prolactin levels above 52 ng/ml for the presence of microadenomas. We examined 55 premenopausal and 19 postmenopausal women, using a 1.5 T unit. We used T1-weighted spin-echo sequences, with coronal and sagittal images before and after intravenous gadolinium. We found microadenomas in 38 patients (51.3%), macroadenomas in 6 (8.1%) and an infundibular glioma in 1;29 patients had a normal pituitary gland (39.2%). The size of the adenomas was related to the prolactin level, and the mean level in patients with MRI evidence of adenomas was higher than in patients without microadenomas (155.72 +/- 131.01 ng/ml versus 110.14 +/- 80.86 ng/ml). The probability of the presence of an adenoma increased with rising serum prolactin levels. We suggest MRI in patients with prolactin levels more than 100 ng/ml. In patients on oestrogen therapy MRI should be performed with only slightly elevated prolactin levels. Evidence of a microadenoma should be considered in planning further therapy, especially concerning the use of hormone replacement therapy or of bromocriptine.
authors.affiliation: Department of Radiology, University of Vienna, Austria.
authors.forename: T
authors.initials: T
authors.lastname: Rand
authors.forename: E
authors.initials: E
authors.lastname: Kink
authors.forename: M
authors.initials: M
authors.lastname: Sator
authors.forename: B
authors.initials: B
authors.lastname: Schneider
authors.forename: J
authors.initials: J
authors.lastname: Huber
authors.forename: H
authors.initials: H
authors.lastname: Imhof
authors.forename: S
authors.initials: S
authors.lastname: Trattnig
mesh_terms: D000236:Adenoma / Q000097:blood / Q000175:diagnosis*; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000097:blood / Q000175:diagnosis*; D011388:Prolactin / Q000097:blood
chemical_list: D011388:Prolactin