title: Macroporous biphasic calcium phosphate ceramics: influence of five synthesis parameters on compressive strength.
abstract: Compressive strength measurements were conducted on 32 macroporous biphasic calcium phosphate (MBCP) samples to evaluate the influences and interactions of five synthesis factors: chemical composition, percentage of macropores, mean size of macropores, isostatic compaction pressure, and sintering temperature. These parameters were varied simultaneously between two limit levels. Experiments used a factorial design method (FDM) allowing optimization of the number of samples as well as statistical analysis of results. FDM showed that compressive strength, in a defined experimental area, can be described by a first-order polynomial equation in which the percentage of macroporosity and sintering temperature are the major influences. This study leads up to an isoresponse line diagram that will allow the manufacture of some classes of MBCP with fitted compressive strength.
authors.affiliation: Centre de Recherche Interdisciplinaire sur les Tissus Calcifiés et les Biomatériaux, Faculté de Chirurgie Dentaire, Nantes, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Bouler
authors.forename: M
authors.initials: M
authors.lastname: Trécant
authors.forename: J
authors.initials: J
authors.lastname: Delécrin
authors.forename: J
authors.initials: J
authors.lastname: Royer
authors.forename: N
authors.initials: N
authors.lastname: Passuti
authors.forename: G
authors.initials: G
authors.lastname: Daculsi
mesh_terms: D018786:Bone Substitutes / Q000138:chemical synthesis*; D002130:Calcium Phosphates / Q000138:chemical synthesis*; D002516:Ceramics / Q000138:chemical synthesis*; D016062:Porosity; D011312:Pressure; D013055:Spectrophotometry, Infrared; D013696:Temperature
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous