title: [Multiple myeloma complicated by necrotizing fasciitis].
abstract: Necrotizing fasciitis is a rare but often fatal soft-tissue infection primarily involving the superficial fascia and fat tissue resulting in extensive undermining of surrounding tissues. Skin is initially spared, but as necrotizing fasciitis spreads, all the soft-tissue components, including the skin, become involved. The progression of necrotizing fasciitis is often fulminant, and the prognosis depends to a large extent on the rapidity of correct diagnosis and surgical treatment (debridement). Most of the patients affected with necrotizing fasciitis have some risk factors: chronic general or local diseases, leukopenia, immunodeficiency diseases, malignancies, and an age of 50 years or more. The author reported the occurrence of necrotizing fasciitis in a 69-year-old man with multiple myeloma during the granulocytopenic phase after chemotherapy. The successful treatment of necrotizing fasciitis in the present case relied not only on surgical debridement, but also on G-CSF administration.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Kyoto University.
authors.forename: T
authors.initials: T
authors.lastname: Kanoh
mesh_terms: D000368:Aged; D003646:Debridement; D019115:Fasciitis, Necrotizing / Q000209:etiology* / Q000601:surgery / Q000628:therapy; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000150:complications*
chemical_list: D016179:Granulocyte Colony-Stimulating Factor