title: Familial neuroblastoma: a three-generation pedigree and a further association with Hirschsprung disease.
abstract: Like the other embryonal cancers of childhood, neuroblastoma occasionally occurs within families. We now provide an update on a nuclear family in which seven individuals are affected with neuroblastoma, inherited in an autosomal dominant fashion over three generations. In addition, two of these individuals are also affected with Hirschsprung disease. This family may lend insight into the molecular pathogenesis of familial neuroblastoma.
authors.affiliation: Division of Oncology, Children's Hospital of Philadelphia, PA 19104, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Maris
authors.forename: J
authors.initials: J
authors.lastname: Chatten
authors.forename: A T
authors.initials: AT
authors.lastname: Meadows
authors.forename: J A
authors.initials: JA
authors.lastname: Biegel
authors.forename: G M
authors.initials: GM
authors.lastname: Brodeur
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006627:Hirschsprung Disease / Q000150:complications*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009447:Neuroblastoma / Q000150:complications* / Q000235:genetics*; D010375:Pedigree