title: A novel mechanism of action of the immunomodulatory drug, leflunomide: augmentation of the immunosuppressive cytokine, TGF-beta 1, and suppression of the immunostimulatory cytokine, IL-2.
authors.affiliation: Probe ID/Department, Chiron Corp, Emeryville, California, USA.
authors.forename: W W
authors.initials: WW
authors.lastname: Cao
authors.forename: P N
authors.initials: PN
authors.lastname: Kao
authors.forename: Y
authors.initials: Y
authors.lastname: Aoki
authors.forename: J C
authors.initials: JC
authors.lastname: Xu
authors.forename: R A
authors.initials: RA
authors.lastname: Shorthouse
authors.forename: R E
authors.initials: RE
authors.lastname: Morris
mesh_terms: D002478:Cells, Cultured; D015870:Gene Expression; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007376:Interleukin-2 / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D007555:Isoxazoles / Q000494:pharmacology*; D019169:Jurkat Cells; D000077339:Leflunomide; D014158:Transcription, Genetic; D016212:Transforming Growth Factor beta / Q000096:biosynthesis*
chemical_list: D007166:Immunosuppressive Agents; D007376:Interleukin-2; D007555:Isoxazoles; D016212:Transforming Growth Factor beta; D000077339:Leflunomide