title: Activation of NMDA and muscarinic receptors induces nur-77 mRNA in hippocampal neurons.
abstract: Using in situ hybridization, we show that the expression of the immediately-early gene, nur-77, increases rapidly and transiently in hippocampal neurons following activation of muscarinic and N-methyl-D-aspartate receptors and after hippocampal long-term potentiation (LTP). On the basis of these results we hypothesize that nur-77 may coordinate with other transcription factors to initiate subsequent changes in hippocampal gene expression associated with plasticity-related activation of N-methyl-D-aspartate and muscarinic receptors.
authors.affiliation: Department of Pharmacology and Clinical Pharmacology, School of Medicine, University of Auckland, New Zealand.
authors.forename: M
authors.initials: M
authors.lastname: Dragunow
authors.forename: W
authors.initials: W
authors.lastname: Abraham
authors.forename: P
authors.initials: P
authors.lastname: Hughes
mesh_terms: D000818:Animals; D001345:Autoradiography; D003513:Cycloheximide / Q000494:pharmacology; D006624:Hippocampus / Q000378:metabolism*; D017403:In Situ Hybridization; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D011976:Receptors, Muscarinic / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D013997:Time Factors
chemical_list: D012333:RNA, Messenger; D011976:Receptors, Muscarinic; D016194:Receptors, N-Methyl-D-Aspartate; D003513:Cycloheximide