Complex translocation [7;22] identified in an epithelioid hemangioendothelioma.
We describe a malignant epithelioid hemangioendothelioma arising in the back of a 45-year-old man with pulmonary and bone marrow metastases. Light microscopic and immunohistochemical features of this tumor are presented. Karyotyping revealed several clonal abnormalities: a complex unbalanced translocation [7;22] involving multiple breakpoints (confirmed by fluorescence in situ hybridization), a Robertsonian t(14;14), and loss of the Y chromosome. Monosomy for chromosome 11 was noted in a subset of the tumor cells. To our knowledge a karyotype has not been previously reported for this unusual vascular tumor.
Boudousquie
A C
AC
Department of Pathology, University Hospital, Oregon Health Sciences University, Portland 97201, USA.
Lawce
H J
HJ
Sherman
R
R
Olson
S
S
Magenis
R E
RE
Corless
C L
CL
D001859:Bone Neoplasms / Q000556:secondary; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D002897:Chromosomes, Human, Pair 7; D018323:Hemangioendothelioma, Epithelioid / Q000235:genetics* / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D006801:Humans; D007621:Karyotyping; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D014178:Translocation, Genetic