title: Widespread increase in brain protein synthesis following acute immobilization stress in adult rat brain.
abstract: The autoradiographic method with [L-35S]methionine was used to determine the effects of a 2 h acute immobilization stress followed by a 4 h recovery on local rates of protein synthesis in the adult rat brain. Methionine incorporation into proteins was significantly increased (from 17 to 86%) in 37 out of the 39 analyzed brain structures. These results show that the stress-induced activation of the overall rate of brain protein synthesis may persist for at least 4 h after cessation of the stimulus even though the stress-related physiological variables have returned to basal levels. They suggest that increased protein synthesis may play a key role in the molecular events which lead to the neuronal plastic changes following an acute stress.
authors.affiliation: CNRS ERS 5645, INSERM U52, Laboratoire de Médecine Expérimentale, UFR Rockefeller, Lyon, France.
authors.forename: V
authors.initials: V
authors.lastname: Baubet
authors.forename: E
authors.initials: E
authors.lastname: Grange
authors.forename: E
authors.initials: E
authors.lastname: Sermet
authors.forename: M
authors.initials: M
authors.lastname: Giaume
authors.forename: N
authors.initials: N
authors.lastname: Gay
authors.forename: P
authors.initials: P
authors.lastname: Bobillier
mesh_terms: D000208:Acute Disease; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D007103:Immobilization; D008297:Male; D008715:Methionine / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D009419:Nerve Tissue Proteins; D008715:Methionine