Effects of extracorporeal shockwave lithotripsy on urinary concentration of epidermal growth factor.
In a prospective study, we tried to determine whether extracorporeal shockwave lithotripsy (SWL) has any effect on urinary epidermal growth factor (EGF) concentrations and to investigate whether EGF can be used as a marker for detecting shockwave-induced impairment of distal tubular cells. A total of 12 patients with renal pelvic or caliceal stones < or = 2 cm undergoing anesthesia-free SWL without ancillary measures and a control group of 10 patients without any urologic symptoms were included in this study. The urinary concentrations of EGF were measured by radioimmunoassay before and 4 hours, 24 hours, and 7 days after SWL. Relative urinary EGF concentrations were expressed as the ratio of EGF to creatinine (ng/mL creatinine). The mean urinary EGF concentration (mean +/- standard error) in control subjects and patients with renal pelvic or caliceal stones before SWL was 23.90 +/- 3.15 ng/mL creatinine and 22.18 +/- 6.85 ng/mL creatinine, respectively (p > 0.05). In patients with stones, we found a decrease in urinary EGF concentration 4 hours, 24 hours, and 7 days after SWL. Indeed, 7 days after SWL, the EGF concentration was on average half of the original value, a biologically significant, although not statistically significant, decrease.
Baltaci
S
S
Department of Urology, Ankara University, Ibn-i Sina Hospital, Turkey.
Ozer
G
G
Soygür
T
T
Yaman
O
O
Sarica
K
K
Müftüoğlu
Y Z
YZ
Göğüş
O
O
D000328:Adult; D015415:Biomarkers / Q000652:urine; D004815:Epidermal Growth Factor / Q000652:urine*; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000628:therapy / Q000652:urine*; D007670:Kidney Calices / Q000000981:diagnostic imaging* / Q000378:metabolism; D007686:Kidney Tubules, Distal / Q000000981:diagnostic imaging / Q000378:metabolism; D008096:Lithotripsy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011863:Radioimmunoassay; D014463:Ultrasonography
D015415:Biomarkers; D004815:Epidermal Growth Factor