title: Renal glomerular fibrosis in a cat.
abstract: Renal glomerular fibrosis was observed in a 1-year-old spayed female Japanese domestic cat that showed clinically advanced renal failure. In the glomeruli, increased homogeneous materials were stained strongly with aniline blue by Masson's trichrome and positive for anti-type III collagen antibody by immunohistochemical staining, causing mesangial sclerosis and capillary collapse. By electron microscopy, randomly arranged fibrils were observed in the expanded subendothelial and mesangial areas, and the fibrils showed periodicity characteristic of collagen fibers in longitudinal sections. These findings of glomerular lesions closely resemble those of human "collagenofibrotic glomerulonephropathy," which has recently been described as a new type of glomerulonephropathy.
authors.affiliation: Department of Veterinary Pathology, Faculty of Agriculture, University of Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: S
authors.initials: S
authors.lastname: Shibata
authors.forename: K
authors.initials: K
authors.lastname: Shirota
authors.forename: K
authors.initials: K
authors.lastname: Abe
authors.forename: K
authors.initials: K
authors.lastname: Uetsuka
authors.forename: H
authors.initials: H
authors.lastname: Nakayama
authors.forename: N
authors.initials: N
authors.lastname: Goto
authors.forename: K
authors.initials: K
authors.lastname: Doi
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002371:Cat Diseases / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology*; D002415:Cats; D003094:Collagen / Q000032:analysis / Q000378:metabolism / Q000648:ultrastructure; D005260:Female; D005921:Glomerulonephritis / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D005947:Glucose / Q000378:metabolism; D007150:Immunohistochemistry; D007678:Kidney Glomerulus / Q000737:chemistry / Q000378:metabolism / Q000473:pathology*; D008854:Microscopy, Electron / Q000379:methods / Q000662:veterinary; D051437:Renal Insufficiency / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary
chemical_list: D001786:Blood Glucose; D003094:Collagen; D005947:Glucose