The antiproliferative effect of leflunomide on vascular smooth muscle cells in vitro is mediated by selective inhibition of pyrimidine biosynthesis.
Nair
R V
RV
Department of Cardiothoracic Surgery, Falk CVRB, Stanford University School of Medicine, California 94305-5247, USA.
Cao
W
W
Morris
R E
RE
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D006086:Graft vs Host Disease / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control; D006151:Guanosine / Q000494:pharmacology; D009131:Muscle, Smooth, Vascular / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D011743:Pyrimidines / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D051381:Rats; D014529:Uridine / Q000494:pharmacology
D011743:Pyrimidines; D006151:Guanosine; D014529:Uridine