A simplified and efficient synthesis of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF).
A new and extremely efficient synthesis of DDATHF from 4-vinylbenzoic acid and bromomalondialdehyde as precursors has been developed which proceeds in 48% overall yield.
Taylor
E C
EC
Department of Chemistry, Princeton University, NJ 08544, USA.
Chaudhari
R
R
Lee
K
K
D000964:Antimetabolites, Antineoplastic / Q000138:chemical synthesis*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis*; D005493:Folic Acid Antagonists / Q000138:chemical synthesis*; D008315:Malondialdehyde / Q000031:analogs & derivatives / Q000737:chemistry; D015394:Molecular Structure; D013343:Styrenes / Q000737:chemistry*; D013763:Tetrahydrofolates / Q000138:chemical synthesis*
D000964:Antimetabolites, Antineoplastic; D004791:Enzyme Inhibitors; D005493:Folic Acid Antagonists; D013343:Styrenes; D013763:Tetrahydrofolates; C083259:bromomalonaldehyde; D008315:Malondialdehyde; C045894:lometrexol; C105064:4-vinylbenzoic acid