title: [Study of acid lability of DNA in patients with leptospirosis].
abstract: Measurements of DNA and study of chromatin status in blood cell nuclei help solve numerous basic problems of biology and medicine. Acid lability of DNA was assessed in 5 patients with grave icterohemorrhagic leptospirosis. The distribution of fluorescence peaks on the curve of neutrophil DNA hydrolysis in patients with grave leptospirosis indicates that functionally low-active acid-resistant DNA fraction predominates in their chromatin. Assessment of acid lability of DNA is proposed to be used for assessing the severity of the pathological process.
authors.forename: M G
authors.initials: MG
authors.lastname: Shubich
authors.forename: A A
authors.initials: AA
authors.lastname: Evglevskiĭ
authors.forename: V V
authors.initials: VV
authors.lastname: Lebedev
authors.forename: M G
authors.initials: MG
authors.lastname: Avdeeva
mesh_terms: D000143:Acids; D000328:Adult; D000368:Aged; D002467:Cell Nucleus / Q000648:ultrastructure; D002843:Chromatin / Q000235:genetics; D004247:DNA / Q000032:analysis*; D005260:Female; D005453:Fluorescence; D006801:Humans; D006868:Hydrolysis; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology; D014895:Weil Disease / Q000175:diagnosis* / Q000235:genetics*
chemical_list: D000143:Acids; D002843:Chromatin; D004247:DNA
vernacular_title: Izuchenie kislotolabil'nosti DNK u bol'nykh leptospirozom.