Breast cancer prognostic significance of some modified urinary nucleosides.
The prognostic significance of six urinary modified nucleosides, 5-methylcytidine (5-MeCyd), 4-acetylcytidine (4-AcCyd), 1-methylinosine (1-MeIno), 1-methyladenosine (1-MeAdo), 7-methylguanosine (7-MeGua) and pseudouridine (psi-Urd) was evaluated in 68 breast cancer patients of the specialized cancer hospital of Lyon (France). Excretions of 1-MeIno and 1-MeAdo were significantly higher in patients hospitalized in the medical rather than surgical ward, reflecting more advanced disease, and also among patients who died within 5 years of follow-up as compared to those still alive. These results suggest an unfavourable prognostic significance of high urinary excretion of 1-MeIno and 1-MeAdo in breast cancer patients.
Sasco
A J
AJ
Program of Epidemiology for Cancer Prevention, International Agency for Research on Cancer, Lyon, France.
Rey
F
F
Reynaud
C
C
Bobin
J Y
JY
Clavel
M
M
Niveleau
A
A
D014408:Biomarkers, Tumor / Q000652:urine*; D001943:Breast Neoplasms / Q000473:pathology / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009705:Nucleosides / Q000652:urine*
D014408:Biomarkers, Tumor; D009705:Nucleosides