Possible roles of retrograde messengers on LTP, LTD, and associative memory.
There are still no clear biophysical models for Associative Long-Term Potentiation (LTP) and Depression (LTD) in the hippocampus, where two populations of synapses targeted to the same receptive field are involved. Here we propose a model that allows an interpretation of the experiments in terms of the molecular processes that may be involved in associative memory. The model suggests that retrograde messengers could have a critical role in the induction and maintenance of associative LTP and LTD, by controlling the coupling between the two populations of synapses.
Migliore
M
M
Institute for Interdisciplinary Applications of Physics, National Research Council, Palermo, Italy. michele@risc2.iaif.pa.cnr.it
Alicata
F
F
Ayala
G F
GF
D004558:Electric Stimulation; D006624:Hippocampus / Q000502:physiology; D017774:Long-Term Potentiation / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D008954:Models, Biological; D009473:Neuronal Plasticity / Q000502:physiology*