title: Interleukin 8 as a novel target for intervention therapy in acute inflammatory diseases.
abstract: Aberrant production of interleukin 8 (IL-8) has been shown in various human inflammatory diseases. Recent investigations in animal models using either blocking antibodies against IL-8 or disruption of the gene encoding the IL-8 receptor have revealed the involvement of IL-8 in the recruitment of neutrophils and in neutrophil-associated tissue injury in acute inflammation. These studies suggest that IL-8 is a novel target to alleviate acute inflammation. This review describes the properties of IL-8 and discusses different therapeutic approaches to target IL-8, particularly the use of humanized monoclonal antibodies against IL-8 and inhibition of IL-8 gene transcription.
authors.affiliation: Department of Hygiene, School of Medicine, Kanazawa University, Ishikawa, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Harada
authors.forename: N
authors.initials: N
authors.lastname: Mukaida
authors.forename: K
authors.initials: K
authors.lastname: Matsushima
mesh_terms: D000818:Animals; D018925:Chemokines / Q000276:immunology; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D016209:Interleukin-8 / Q000737:chemistry / Q000276:immunology*; D015394:Molecular Structure; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D018925:Chemokines; D016209:Interleukin-8