title: Immunoglobulin A (IgA) deposits in lesional skin of a patient with blepharochalasis.
abstract: We describe a 21-year-old male patient with blepharochalasis, a form of localized acquired cutis laxa. He had a 13-year history of recurrent swelling attacks of the eyelids of unknown origin leading to periocular localized cutis laxa. Histology of lesional skin confirmed almost complete loss of elastic fibres in the reticular and papillary dermis. Immunofluorescence and immunoelectron microscopy studies showed abundant immunoglobulin A (IgA) deposits around the remaining elastic fibres. Control skin of the forearm was negative. These findings support the hypothesis that immunopathogenetic mechanisms may contribute to the elastolytic process of blepharochalasis.
authors.affiliation: Department of Dermatology, University of Innsbruck, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Grassegger
authors.forename: N
authors.initials: N
authors.lastname: Romani
authors.forename: P
authors.initials: P
authors.lastname: Fritsch
authors.forename: J
authors.initials: J
authors.lastname: Smolle
authors.forename: H
authors.initials: H
authors.lastname: Hintner
mesh_terms: D000328:Adult; D003483:Cutis Laxa / Q000276:immunology* / Q000473:pathology; D005141:Eyelid Diseases / Q000276:immunology* / Q000473:pathology; D005143:Eyelids / Q000473:pathology; D005455:Fluorescent Antibody Technique; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D008297:Male; D016253:Microscopy, Immunoelectron
chemical_list: D007070:Immunoglobulin A