title: Incidence and outcome of arterial complications after orthotopic liver transplantation.
abstract: Arterial complications can be a major factor in morbidity and mortality after orthotopic liver transplantation (OLT), as they may cause graft failure, sepsis and complications of the biliary tract. From September 1988 to December 1994, 571 OLT were performed in 529 patients. The follow-up period ranged from 8 to 83 months. Actuarial 1-, 3- and 5-year survival figures were 91%, 87% and 85%, respectively. In 12 cases (2.1%) complications of the arterial anastomoses were observed. Early arterial complications occurred in eight cases from various causes, while late arterial complications were exclusively thromboses and developed in four patients 8, 12, 26 and 37 months after surgery, respectively. The main clinical course in patients with arterial thromboses was septic cholangitis with destruction of the biliary tree. Although 70% of the grafts with arterial thrombosis were lost, 30% could, at least temporarily, be salvaged by other treatment options. Provided adequate treatment is carried out, arterial complications do not affect overall patient survival.
authors.affiliation: Department of Surgery, Virchow Clinic, Humboldt University, Berlin, Germany.
authors.forename: H P
authors.initials: HP
authors.lastname: Lemmens
authors.forename: U
authors.initials: U
authors.lastname: Neumann
authors.forename: W O
authors.initials: WO
authors.lastname: Bechstein
authors.forename: O
authors.initials: O
authors.lastname: Guckelberger
authors.forename: R
authors.initials: R
authors.lastname: Lüsebrink
authors.forename: S
authors.initials: S
authors.lastname: Jonas
authors.forename: H
authors.initials: H
authors.lastname: Keck
authors.forename: P
authors.initials: P
authors.lastname: Neuhaus
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D006085:Graft Survival; D006801:Humans; D015994:Incidence; D016031:Liver Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D013927:Thrombosis / Q000453:epidemiology / Q000209:etiology*