Carotid intima-media thickening and in vivo LDL oxidation in patients with essential hypertension.
Low density lipoproteins (LDL) from hypertensive patients are more prone to in vitro oxidation and undergo a more pronounced oxidation in vivo. Due to the pro-atherogenic activity of oxidatively modified LDL, the correlation between the carotid intima-media thickening (IMT) and the markers of in vivo LDL oxidation was investigated in hypertensive patients. A cross-sectional study on 101 normocholesterolemic patients with newly diagnosed and untreated essential hypertension was performed. The occurrence of in vivo LDL oxidation was evaluated by measuring the titers of autoantibodies against Cu(2+)-oxidised LDL (oxLDL) and malondialdehyde-derivatised LDL (MDA-LDL). The extent and degree of atherosclerosis and the IMT were measured by means of carotid and femoral ultrasonography with a duplex scanner equipped with a high resolution probe. We did not find significant correlations between in vivo LDL oxidation parameters and the extent of atherosclerotic lesion in the entire group of hypertensive patients. However, a significant direct correlation was detected between the carotid IMT and the titer of autoantibodies against both oxLDL and MDA-LDL in hypertensive patients without advanced atherosclerotic plaques. The results obtained support the hypothesis that enhanced LDL oxidation may be one of the pathophysiological events related to the formation and progression of early atherosclerotic lesions (IMT) in carotid arteries of hypertensive patients.
Marchesi
E
E
Department of Internal Medicine and Medical Therapeutics, University of Pavia, Italy.
Martignoni
A
A
Salvini
M
M
Catalano
O
O
Maggi
E
E
Negro
C
C
Traversa
B
B
Bellomo
G
G
D000328:Adult; D001161:Arteriosclerosis / Q000209:etiology; D001323:Autoantibodies / Q000097:blood; D002339:Carotid Arteries / Q000473:pathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000378:metabolism / Q000473:pathology*; D008077:Lipoproteins, LDL / Q000276:immunology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction
D001323:Autoantibodies; D008077:Lipoproteins, LDL