Diagnosis of patients presenting to a Huntington disease (HD) clinic without a family history of HD.
About 9% of patients presenting to a Huntington disease (HD) clinic for evaluation of possible HD lacked a family history of the disorder. HD was the final diagnosis in 53 to 83% of these patients. As a group, HD-affected individuals without a family history of HD were older and had fewer CAG repeats than the average HD patient. Some patients presenting with chorea only had HD and others did not; patients developing a movement disorder after long-standing neuroleptic-treated psychiatric illness did not have HD.
Nance
M A
MA
Department of Neurology, Hennepin County Medical Center, Minneapolis, MN 55415, USA.
Westphal
B
B
Nugent
S
S
D000328:Adult; D000368:Aged; D004247:DNA / Q000032:analysis; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis* / Q000235:genetics; D008297:Male; D008487:Medical History Taking; D008875:Middle Aged; D012091:Repetitive Sequences, Nucleic Acid
D004247:DNA