title: [What is anesthesia? Some reflections on the definition, measuring methods and mechanisms at the 150th anniversary].
abstract: Modern anaesthesia has developed over 150 years. In spite of this, we still do not know how to explain the state of anaesthesia exactly, how to measure anaesthesia nor what the basic mechanisms are. In this paper, a model for the state of anaesthesia, is presented, and some aspects of basic mechanisms and monitoring are discussed. Anaesthesia modulates or blocks the somatic and autonomic responses to injury, mainly by postsynaptic inhibition of impulses. Empirical dosing and clinical monitoring are still the rule, computerized and electronic systems need to be further refined.
authors.affiliation: Anestesiavdelingen, Ullevål Sykehus, Oslo.
authors.forename: J C
authors.initials: JC
authors.lastname: Raeder
mesh_terms: D000758:Anesthesia / Q000266:history* / Q000379:methods; D000768:Anesthesia, General / Q000266:history / Q000379:methods; D000772:Anesthesia, Local / Q000266:history / Q000379:methods; D000777:Anesthetics / Q000008:administration & dosage / Q000266:history / Q000494:pharmacology; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D008954:Models, Biological; D008991:Monitoring, Physiologic; D009626:Terminology as Topic
chemical_list: D000777:Anesthetics
vernacular_title: Hva er anestesi? Noen betraktninger over definisjon, målemetoder og virkningsmekanismer ved et 150-årsjubileum.