Iron therapy resistant microcytic anaemia in a 13-year-old girl with Castleman disease.
We describe the case history of a 13-year-old girl with chronic fatigue and prolonged microcytic anaemia. She received oral iron since the age of 11 but failed to respond to it. Laboratory studies revealed elevated C-reactive protein and hypergammaglobulinaemia. A large solitary mesenterial lymph node could be demonstrated by ultrasonography and CT. A diagnosis of Castleman disease was suspected and confirmed histologically. After surgical removal of the lymphoma the patient recovered completely.


CONCLUSIONS
Castleman disease should be considered in cases of chronic fatigue, unexplained fever, microcytic anaemia and hypergammaglobulinaemia.
De Heer-Groen
T A
TA
Hospital Centre Apeldoorn, The Netherlands.
Prakken
A B
AB
Bax
N M
NM
van Dijken
P J
PJ
D000293:Adolescent; D000740:Anemia / Q000188:drug therapy / Q000209:etiology*; D005871:Castleman Disease / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006801:Humans; D007501:Iron / Q000627:therapeutic use
D007501:Iron