Studies on endothelin receptors in the zonae fasciculata/reticularis of the rat adrenal cortex: contrast with the zona glomerulosa.
This study investigated the ET(A) and ET(B) receptor subtypes in rat adrenal cortex. The ET(A) antagonist, BQ-123, inhibited the zona glomerulosa (zg), but not the inner zone (iz) response to ET-1. RES-701-1, the ET(B) antagonist, abolished the iz response to ET-1, but had less effect on the zg. [125I]ET-1 binding studies revealed two receptor subtypes in both zones, with ET(A) predominating in the zg, and ET(B) in the iz. These data suggest that the ET(A) subtype is functionally more important in the zg while the ET(B) receptor is the major subtype in the inner zones.
Kapas
S
S
Department of Biochemistry, Faculty of Medical Sciences, Queen Mary and Westfield College, London, UK.
Cameron
L A
LA
Puddefoot
J R
JR
Hinson
J P
JP
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000450:Aldosterone / Q000378:metabolism; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D003345:Corticosterone / Q000378:metabolism; D065128:Endothelin Receptor Antagonists; D019332:Endothelin-1 / Q000378:metabolism / Q000494:pharmacology; D005260:Female; D008297:Male; D010456:Peptides, Cyclic / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D044022:Receptor, Endothelin A; D044023:Receptor, Endothelin B; D017466:Receptors, Endothelin / Q000378:metabolism*; D015383:Zona Fasciculata / Q000378:metabolism*; D015384:Zona Glomerulosa / Q000378:metabolism*; D015385:Zona Reticularis / Q000378:metabolism*
D065128:Endothelin Receptor Antagonists; D019332:Endothelin-1; D010456:Peptides, Cyclic; D044022:Receptor, Endothelin A; D044023:Receptor, Endothelin B; D017466:Receptors, Endothelin; D000804:Angiotensin II; C087120:RES 701-1; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; C072247:cyclo(Trp-Asp-Pro-Val-Leu); D003345:Corticosterone