title: Left atrial spontaneous echo contrast in asymptomatic patients with a mechanical valve prosthesis.
abstract: BACKGROUND
  Valve thromboembolism may be a fatal complication of mechanical valve prosthesis if detected late. Spontaneous echo contrast (SEC) is a well-documented prothrombotic phenomenon; here we report it in asymptomatic patients with a mechanical valve prosthesis.
  
  
  METHODS
  Ninety-two asymptomatic patients with a mechanical valve prosthesis for underlying rheumatic heart disease underwent transesophageal echocardiography. Appendage area, peak filling and emptying velocities of the left atrial appendage, and the presence or absence of SEC and thrombi were determined. The results of 56 patients without SEC or thrombi (group I) were compared with those of 24 patients with SEC and no thrombi (group II) and 12 patients with thrombi (group III).
  
  
  RESULTS
  Spontaneous echo contrast was present in 39% of the asymptomatic patients with a mechanical valve prosthesis. Although 12 patients had cardiac thrombi, including valve thrombi in 4, no patients presented symptoms. Anticoagulant therapy had no significant association with SEC and atrial thrombi. There was a significantly greater prevalence of atrial fibrillation and mitral prosthesis in groups II and III than in group I. Two patterns of left atrial appendage flow were identified: one was organized biphasic flow with peak filling velocities of 41.2 +/- 17.2 cm/s and emptying velocities of 40.5 +/- 17.5 cm/s. The other showed irregular, very low peak filling velocities (104 +/- 11.5 cm/s) and emptying velocities (12.3 +/- 13.1 cm/s). The former flow pattern was associated with sinus rhythm and the latter form was associated with atrial fibrillation.
  
  
  CONCLUSIONS
  There was a relatively high prevalence of SEC and thrombi in patients with a mechanical valve prosthesis. Patients with a valve prosthesis may not have clinical symptoms. Anticoagulation intensity was not associated with the occurrence of SEC and thrombi. Patients with the mitral valve prosthesis and atrial fibrillation were identified as a high-risk of subgroup for the development of SEC and thrombi.
authors.affiliation: Department of Internal Medicine, College of Medicine, National Taiwan University, National Taiwan University Hospital, Taipei.
authors.forename: T M
authors.initials: TM
authors.lastname: Lee
authors.forename: N K
authors.initials: NK
authors.lastname: Chou
authors.forename: S F
authors.initials: SF
authors.lastname: Su
authors.forename: Y J
authors.initials: YJ
authors.lastname: Lin
authors.forename: M F
authors.initials: MF
authors.lastname: Chen
authors.forename: C S
authors.initials: CS
authors.lastname: Liau
authors.forename: Y T
authors.initials: YT
authors.lastname: Lee
authors.forename: S H
authors.initials: SH
authors.lastname: Chu
mesh_terms: D000328:Adult; D000368:Aged; D017548:Echocardiography, Transesophageal; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging*; D006331:Heart Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013927:Thrombosis / Q000000981:diagnostic imaging* / Q000209:etiology