Phototesting in bath-PUVA: marked reduction of 8-methoxypsoralen (8-MOP) activity within one hour after an 8-MOP bath.
It is not known how long after 8-MOP bath-PUVA administration erythema can be induced. Therefore, after determination of dose-dependence and kinetics of bath-PUVA erythema, we investigated the development of erythema using an erythematogenic UVA-dose (3 J/cm2) in time course experiments. Our results show that there is a loss of biological 8-MOP activity already 1 h after 8-MOP bath. This has important consequences for clinical practice with bath-PUVA, concerning the optimum time interval between the 8-MOP bath and irradiation as well as the persistence of photosensitivity in normal skin after bath-PUVA.
Schempp
C M
CM
Department of Dermatology, University Medical Center Freiburg, Germany.
Schöpf
E
E
Simon
J C
JC
D001494:Baths; D004305:Dose-Response Relationship, Drug; D004890:Erythema / Q000209:etiology / Q000473:pathology; D006801:Humans; D008730:Methoxsalen / Q000008:administration & dosage* / Q000493:pharmacokinetics; D011701:PUVA Therapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D013997:Time Factors
D017319:Photosensitizing Agents; D008730:Methoxsalen