title: Molecular biology and the development of AIDS therapeutics.
abstract: BACKGROUND
  Although promising, current AIDS therapies are limited by their toxicity, their cost, and by the emergence of drug-resistant variants.
  
  
  OBJECTIVE
  The molecular study of HIV replication can lean to the discovery of better treatments, by identifying unexplored targets and facilitating the development of novel classes of antivirals.
  Major insights were recently gained in the areas of HIV entry and nuclear transport, suggesting new approaches for the control of viral replication.
  Intensifying the support to basic HIV research, and promoting interactions between academic scientists and the pharmaceutical industry.
authors.affiliation: Salk Institute for Biological Studies, La Jolla, CA 92037-1099, USA.
authors.forename: D
authors.initials: D
authors.lastname: Trono
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D000998:Antiviral Agents / Q000627:therapeutic use; D006678:HIV / Q000502:physiology*; D006801:Humans; D014779:Virus Replication
chemical_list: D000998:Antiviral Agents