title: Echolucent carotid artery plaques are associated with elevated levels of fasting and postprandial triglyceride-rich lipoproteins.
abstract: OBJECTIVE
  Echolucent carotid atherosclerotic plaques are associated with an increased risk of neurological symptoms. Elevated plasma triglycerides is a risk factor for cerebral and coronary infarction. This study examined these individual pathogenetic risk factors to determine whether they were related.
  
  
  METHODS
  We included 85 symptomatic patients with at least 40% carotid artery stenosis. Plaque morphology of the relevant artery was evaluated by high-resolution B-mode ultrasonography as echolucent, echo-rich, or intermediate. Fasting and postprandial lipids and lipoproteins were measured before and at hourly intervals for 4 hours after a fatty meal (1 g cream fat per kilogram body weight).
  
  
  RESULTS
  When we compared patients with echolucent plaques to patients with echo-rich or intermediate plaques, the former had higher fasting and postprandial plasma triglycerides (P < or = .006), higher chylomicron remnants/VLDL cholesterol (P = .02) and triglycerides (P < or = .004), a larger area under the plasma triglyceride curve 0 to 4 hours after a fatty meal, with (AUCTG-TG oh) or without (AUCTG) subtraction of fasting levels (P = .007 and P = .003), a larger body mass index (P = .03), and were younger (P = .01). Multiple logistic regression analysis found that when age and body mass index were taken into account, fasting plasma and VLDL triglycerides, postprandial chylomicron remnants/VLDL triglycerides, AUCTG-TG oh and AUCTG with odds ratios of 4.1, 3.8, 3.0, 2.7, and 4.3, respectively, were independent predictors of an echolucent plaque.
  
  
  CONCLUSIONS
  Echolucent carotid artery plaques are associated with elevated levels of triglyceride-rich lipoproteins in the fasting or postprandial state.
authors.affiliation: Department of Vascular Surgery, Rigshospitalet, Copenhagen, Denmark. mlg@rh.dk
authors.forename: M L
authors.initials: ML
authors.lastname: Grønholdt
authors.forename: B G
authors.initials: BG
authors.lastname: Nordestgaard
authors.forename: T G
authors.initials: TG
authors.lastname: Nielsen
authors.forename: H
authors.initials: H
authors.lastname: Sillesen
mesh_terms: D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging*; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000150:complications; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D016893:Carotid Stenosis / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging*; D002914:Chylomicrons / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology; D004435:Eating; D005215:Fasting; D005260:Female; D006801:Humans; D008079:Lipoproteins, VLDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011237:Predictive Value of Tests; D016037:Single-Blind Method; D014280:Triglycerides / Q000097:blood*; D014463:Ultrasonography
chemical_list: D002914:Chylomicrons; D004041:Dietary Fats; D008079:Lipoproteins, VLDL; D014280:Triglycerides