Genetic analysis of a complex disease.
A complex disease may be defined as a disease that has a complex phenotype, no single causal agent and a range of influencing factors, both genetic and environment. The paper considers how the aetiology of such disorders may be unravelled using recently developed genetical and statistical methods. Problems are illustrated using ischaemic heart disease, congenital neural tube defects and depression as examples.
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CSIRO Division of Animal Production, Blacktown, NSW, Australia.
D003327:Coronary Disease / Q000235:genetics*; D003863:Depression / Q000235:genetics*; D005260:Female; D005821:Genetic Techniques; D006801:Humans; D008297:Male; D008957:Models, Genetic; D009436:Neural Tube Defects / Q000235:genetics*; D017678:Sex Distribution