[Selenium deficiency in patients with cardiovascular diseases and its correction with the drug "selena"].
Blood selenium concentrations, erythrocytic glutathione peroxidase (GPO) activity, and plasma lipid peroxides were investigated in patients with ischemic heart disease (IHD) and dilated cardiomyopathy (DCMP). Patients with IHD and DCMP displayed depressed activity of GPO with activation of lipid peroxides associated with lower blood selenium. The daily intake of 300 micrograms of selenium from Selena during a month treatment augmented selenium concentrations by 71% in IHD and DCMP patients. This augmentation showed an inverse correlation with primary plasma selenium concentrations. Plasma malonic dialdehyde levels decreased by 17%. The findings suggest that selenium is involved in the pathogenesis of DCMP and IHD, which may be a ground for selecting patients with selenium deficiency for its correction with Selena.
Lebedev
P A
PA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012643:Selenium / Q000172:deficiency*; D018036:Selenium Compounds / Q000627:therapeutic use*
D018036:Selenium Compounds; D012643:Selenium
Selenodefitsit u bol'nykh s serdechno-sosudistymi zabolevaniiami i ego korrektsiia preparatom "selena".