Tumour necrosis factors in immune regulation: everything that's interesting is...new!
Tumour necrosis factors have been classically studied as molecules central to the pathogenesis of infectious, inflammatory and autoimmune diseases. The recent generation of mice deficient in TNF alpha, LT alpha, or their receptors, has provided exciting new insights into the physiological role of these molecules in the development of secondary lymphoid tissues and in the organisation of the humoral immune response.
Pasparakis
M
M
Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece.
Alexopoulou
L
L
Douni
E
E
Kollias
G
G
D000818:Animals; D001419:Bacteria / Q000276:immunology / Q000472:pathogenicity; D001424:Bacterial Infections / Q000276:immunology*; D005314:Embryonic and Fetal Development; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D008198:Lymph Nodes / Q000196:embryology / Q000276:immunology; D008221:Lymphoid Tissue / Q000502:physiology* / Q000648:ultrastructure; D051379:Mice; D008822:Mice, Transgenic; D018124:Receptors, Tumor Necrosis Factor / Q000276:immunology / Q000502:physiology; D013154:Spleen / Q000033:anatomy & histology / Q000502:physiology / Q000648:ultrastructure; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000276:immunology* / Q000502:physiology
D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha