Neurologic complications after allogeneic bone marrow transplantation.
Neurological complications are not usually considered among the most important complications that may appear after allogeneic bone marrow transplantation (BMT). We have analyzed the occurrence of neurological manifestation in 27 recipients of allogeneic BMT. Ten patients (37%) developed neurological symptoms, and 14 episodes were registered. The most frequent manifestations were due to the use of cyclosporin A or prednisone for prophylaxis or treatment of graft-versus-host disease (GVHD). Cerebrovascular events (infarction or hemorrhage) and CNS infections were the most severe complications: they represented 26% of cause of death in our series. In conclusion, neurological complications are frequent in these patients, and represent an important cause of morbidity and mortality.
Gallardo
D
D
Department of Clinical Hematology, Hospital Duran i Reynals, Barcelona, Spain.
Ferrà
C
C
Berlanga
J J
JJ
Banda
E D
ED
Ponce
C
C
Salar
A
A
Alonso
E
E
Espanñol
I
I
Riu
C
C
Grañena
A
A
D016026:Bone Marrow Transplantation; D001922:Brain Abscess / Q000453:epidemiology / Q000209:etiology; D002066:Busulfan / Q000009:adverse effects; D002561:Cerebrovascular Disorders / Q000453:epidemiology / Q000209:etiology; D016572:Cyclosporine / Q000009:adverse effects*; D004660:Encephalitis / Q000453:epidemiology / Q000209:etiology; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced / Q000453:epidemiology; D006086:Graft vs Host Disease / Q000188:drug therapy / Q000517:prevention & control; D006801:Humans; D015994:Incidence; D008275:Magnesium Deficiency / Q000150:complications; D009181:Mycoses / Q000453:epidemiology / Q000209:etiology; D009422:Nervous System Diseases / Q000453:epidemiology / Q000209:etiology*; D009468:Neuromuscular Diseases / Q000139:chemically induced; D011239:Prednisolone / Q000009:adverse effects*; D019172:Transplantation Conditioning / Q000009:adverse effects
D016572:Cyclosporine; D011239:Prednisolone; D002066:Busulfan