Development of acromegaly during treatment of hyperprolactinemia with bromocriptine: an unusual acidophil stem cell adenoma.
We present clinical details of a patient with a 20-yr history of amennorhea, a pituitary tumor, elevated PRL levels, and initially undetectable GH. Bromocriptine failed to fully suppress PRL, and there was no tumor shrinkage. Within 7 months of starting bromocriptine treatment, the patient developed clinical and biochemical signs of acromegaly. At surgery, a stem cell adenoma was excised. The mechanisms by which bromocriptine may have resulted in the development of acromegaly in this patient are discussed.
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M D
MD
Department of Endocrinology, General Infirmary, Leeds, United Kingdom.
Bridges
L R
LR
Barth
J H
JH
McNichol
A M
AM
Belchetz
P E
PE
D000172:Acromegaly / Q000209:etiology*; D000239:Adenoma, Acidophil / Q000209:etiology*; D000328:Adult; D001971:Bromocriptine / Q000009:adverse effects*; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006727:Hormone Antagonists / Q000009:adverse effects*; D006801:Humans; D006966:Hyperprolactinemia / Q000188:drug therapy*; D010911:Pituitary Neoplasms / Q000209:etiology*
D006727:Hormone Antagonists; D001971:Bromocriptine; D013006:Growth Hormone