Effect of preoperative thoracic duct drainage on canine kidney transplantation.
Chronic drainage of the thoracic duct to the esophagus was developed in dogs, and its efficacy in immunomodulation was tested using kidney transplantation. Compared to 9.7 days in the control, the mean animal survival was prolonged to 9.9 days, 17.8 days, and 18.5 days when TDD was applied preoperatively for 3 weeks, 6 weeks, and 9 weeks, respectively. Prolongation was significant after 6 weeks. Patency of the fistula was 93.5, 80.4, and 76.1% at respective weeks. Number of peripheral T-lymphocytes determined by a new monoclonal antibody diminished after 3 weeks. All animals were in normal health, requiring no special care for fluid, electrolyte, or protein replacement.
Funakoshi
Y
Y
Department of Surgery and Pathology, University Health Center of Pittsburgh, University of Pittsburgh, Pennsylvania, USA.
Carrieri
G
G
Yagihashi
A
A
Iwaki
Y
Y
Todo
S
S
Starzl
T E
TE
D000818:Animals; D000911:Antibodies, Monoclonal; D004285:Dogs; D004322:Drainage; D004947:Esophagus; D005260:Female; D006085:Graft Survival / Q000276:immunology; D016030:Kidney Transplantation / Q000276:immunology / Q000379:methods* / Q000502:physiology; D018655:Lymphocyte Count; D015996:Survival Rate; D013601:T-Lymphocytes / Q000276:immunology*; D013897:Thoracic Duct / Q000601:surgery*; D013997:Time Factors; D014184:Transplantation, Homologous
D000911:Antibodies, Monoclonal