Do some antiphospholipid antibodies target endothelial cells?
Anti-endothelial cell activity is partly due to antiphospholipid antibodies (aPLA) because: a) the two types of antibodies are present in patients with connective tissue diseases and cardiolipin-binding monoclonal antibodies recognize endothelial cells (EC); b) anionic phospholipids are detectable on the outer face of the EC membrane lipid bilayer and an anti-beta 2-glycoprotein I (beta 2-GPI) monoclonal antibody binds to EC; c) the binding of aPLA to EC and the functional affinity of this binding are dependent on the presence of beta 2-GPI; d) anti-EC antibodies trigger the expression of anionic phospholipids on the outer leaflet of the EC membrane.
Dueymes
M
M
Laboratoire d'Immunologie, CHU, Brest, France.
Levy
Y
Y
Ziporen
L
L
Jamin
C
C
Piette
J C
JC
Shoenfeld
Y
Y
Youinou
P
P
D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000276:immunology; D002308:Cardiolipins / Q000276:immunology; D003240:Connective Tissue Diseases / Q000276:immunology*; D004727:Endothelium / Q000166:cytology* / Q000276:immunology; D006801:Humans
D017152:Antibodies, Antiphospholipid; D000911:Antibodies, Monoclonal; D002308:Cardiolipins