Dominant inhibition of intercellular communication by two chimeric connexins.
1. The physiological significance of communication through gap junction channels has been difficult to assess because channel activity cannot be experimentally modulated in a specific manner. To address this problem we have constructed chimeric connexins that function as dominant-negative inhibitors of intercellular channel activity.
Goliger
J A
JA
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Bruzzone
R
R
White
T W
TW
Paul
D L
DL
D000818:Animals; D002450:Cell Communication / Q000187:drug effects*; D017630:Connexins / Q000235:genetics* / Q000494:pharmacology*; D004594:Electrophysiology; D005354:Fibrosarcoma; D051379:Mice; D008845:Microinjections; D009865:Oocytes / Q000502:physiology; D011993:Recombinant Fusion Proteins / Q000494:pharmacology*; D014162:Transfection; D014407:Tumor Cells, Cultured; D014981:Xenopus
D017630:Connexins; D011993:Recombinant Fusion Proteins