Drug release from lipid matrices. Part II. Influence of formulation factors on the release of slightly soluble drug.
The aim of this study was to investigate the effect of the formulation parameters on the release of water slightly soluble drug from the lipid matrices. Ibuprofen and hydrogenated cotton seed oil were used as the slightly soluble drug and matrice material, respectively. The preparations satisfying sustained release dosage form of Ibuprofen was also investigated. The effect of preparation method particle size of granules and the compression forces for tabletting process were determined by dissolution rate studies. Upon the evaluation of dissolution data, the temperature applied to the matrix material and the preparation method were found to be important factors for the release of active substance whereas the particle size of granules and the compression forces have no effect.
Ozdemir
N
N
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Ankara, Turkey.
Ozates
B
B
D002725:Chloroform; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D007052:Ibuprofen / Q000378:metabolism*; D050356:Lipid Metabolism; D010316:Particle Size; D012997:Solvents; D014835:Volatilization
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D012997:Solvents; D002725:Chloroform; D007052:Ibuprofen