[Predictive information of basic indices of biochemical status of a man in evaluating the tolerance to acute hypoxia].
Under simulation of acute hypoxic hypoxia with participating the volunteers (men) there has been studied the predictor significance of the biochemical indices characterising an intensity of lipoperoxidation process, hormonal status and level of fermentemia. It is indicated that the following indices, namely, LDH, a [symbol: see text]-DPDH, MPD, secondary products of POL, SOD, insulin, cAMP and cAMP/cGMP have the prognostic validity. The revealed combination of the reliable relations was approximated by the equations of one-factor regression. As this takes place, the analysis of the presented dependencies between tolerance for hypoxia and biochemical indices allowed one to recognize the most probable mechanisms of resistance to the effect of this factor. The performed discrimination analysis for 6 biochemical variables (cAMP, LDH, SOD, MPO, MDA, TC) made it possible to create discriminant equations and to formulate the decisive rules to class the individuals into the ranks with different tolerance to the oxygen deficiency. The high informative capacity of the mentioned approach is recommended by the authors for a more wide use when developed the expert system to evaluate the human functional state as applied to the effect of extreme environmental factors and activity.
Nagornev
S N
SN
State Scientific Experimental Institute of Aerospace Medicine MO RF.
Bobrovnitskii
I P
IP
Cherniakov
I N
IN
Shishov
A A
AA
D015104:3,4-Methylenedioxyamphetamine / Q000097:blood*; D000208:Acute Disease; D000222:Adaptation, Physiological; D000328:Adult; D000337:Aerospace Medicine; D000531:Altitude; D015415:Biomarkers / Q000097:blood; D000242:Cyclic AMP / Q000097:blood*; D016002:Discriminant Analysis; D006801:Humans; D000860:Hypoxia / Q000097:blood*; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D015227:Lipid Peroxidation; D008297:Male; D009195:Peroxidase / Q000097:blood*; D011379:Prognosis; D011863:Radioimmunoassay; D012016:Reference Values; D013482:Superoxide Dismutase / Q000097:blood*; D014155:Transcobalamins / Q000378:metabolism*
D015415:Biomarkers; D014155:Transcobalamins; D015104:3,4-Methylenedioxyamphetamine; D000242:Cyclic AMP; D007770:L-Lactate Dehydrogenase; D009195:Peroxidase; D013482:Superoxide Dismutase
Prognosticheskaia informativnost iskhodnykh pokazatelei biokhimicheskogo statusa cheloveka v otsenke perenosimosti ostroi gipoksicheskoi gipoksii.