The antibacterial activity of amoxycillin/clavulanic acid against Staphylococcus aureus ingested by human granulocytes.
The effect of amoxycillin, and amoxycillin/clavulanic acid on the in vitro interaction between human polymorphonuclear cells and a beta-lactamase producing strain of Staphylococcus aureus was investigated. Amoxycillin alone, at half the MIC, significantly inhibited the bacterial uptake by polymorphonuclear (PMN) cells compared with the control; as a consequence the killing of intracellular staphylococci was higher. Clavulanic acid did not have any significant effect upon the activities of phagocytes. The combination amoxycillin/clavulanic acid possesses beneficial properties which result in enhancement of both phagocytosis and microbicidal activity of PMN cells against the beta-lactamase producing strain of S. aureus. A synergic effect between drugs and serum activity was noted.
Cuffini
A M
AM
Institute of Microbiology, University of Turin, Italy.
Tullio
V
V
Allocco
A
A
Paizis
G
G
Carlone
N A
NA
D000658:Amoxicillin / Q000494:pharmacology*; D001770:Blood Bactericidal Activity / Q000187:drug effects; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000494:pharmacology*; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology*; D010406:Penicillins / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000276:immunology; D065093:beta-Lactamase Inhibitors
D002969:Clavulanic Acids; D004791:Enzyme Inhibitors; D010406:Penicillins; D065093:beta-Lactamase Inhibitors; D019818:Clavulanic Acid; D000658:Amoxicillin