Systemic overexpression of a C-terminal fragment of human amyloid beta-protein precursor causes accumulation of Alzheimer beta-amyloid fibrils in pancreas of transgenic mice.
The deposition of amyloid beta-protein (A beta), derived from amyloid beta-protein precursor (beta APP), is a specific and early event in development of Alzheimer's disease. Transgenic mice carrying the carboxyl-terminus of beta APP gene linked to the cytomegalovirus enhancer/chicken beta-actin promoter sequence were studied. Deposition of amyloid fibrils, composing A beta, was observed in the transgenic pancreas, accompanied with cell degeneration. This result will provide a model to investigate the beta APP processing mechanism in vivo and a clue to generate possible A beta amyloidosis in animal brains.
Shoji
M
M
Department of Neurology, Gunma University School of Medicine, Maebashi, Japan.
Kawarabayashi
T
T
Sato
M
M
Sasaki
A
A
Matsubara
E
E
Iizuka
T
T
Harigaya
Y
Y
Hirai
S
S
D000199:Actins / Q000235:genetics; D000544:Alzheimer Disease / Q000473:pathology*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D002645:Chickens / Q000235:genetics; D003587:Cytomegalovirus / Q000235:genetics; D004742:Enhancer Elements, Genetic; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics; D008854:Microscopy, Electron; D010179:Pancreas / Q000378:metabolism* / Q000473:pathology*; D010446:Peptide Fragments / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D019076:Transgenes
D000199:Actins; D016564:Amyloid beta-Protein Precursor; D010446:Peptide Fragments