title: [The clinical application of long-acting preparations of theophylline].
abstract: The advantage of long-acting preparations of theophylline in clinical practice is that they can be used to maintain a stable concentration of the drug in blood for long periods of time. These preparations are also particularly useful in non-compliant patients. In addition, by reducing the circadian variation in the concentration of theophylline in blood they reduce the risk of early morning asthma attacks. In a survey of physicians in private practice, 63% said that theophylline preparations are appropriate as drugs of first choice in treating asthma, and the average of the reported daily doses was 369.5 mg.
authors.affiliation: Department of Internal Medicine, Showa University Toyosu Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002940:Circadian Rhythm; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010820:Physicians; D011795:Surveys and Questionnaires; D013806:Theophylline / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D001993:Bronchodilator Agents; D003692:Delayed-Action Preparations; D013806:Theophylline