Potent, selective, orally active 3-oxo-1,4-benzodiazepine GPIIb/IIIa integrin antagonists.
Samanen
J M
JM
Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA.
Ali
F E
FE
Barton
L S
LS
Bondinell
W E
WE
Burgess
J L
JL
Callahan
J F
JF
Calvo
R R
RR
Chen
W
W
Chen
L
L
Erhard
K
K
Feuerstein
G
G
Heys
R
R
Hwang
S M
SM
Jakas
D R
DR
Keenan
R M
RM
Ku
T W
TW
Kwon
C
C
Lee
C P
CP
Miller
W H
WH
Newlander
K A
KA
Nichols
A
A
Parker
M
M
Peishoff
C E
CE
Rhodes
G
G
Ross
S
S
Shu
A
A
Simpson
R
R
Takata
D
D
Yellin
T O
TO
Uzsinskas
I
I
Venslavsky
J W
JW
Yuan
C K
CK
Huffman
W F
WF
D000284:Administration, Oral; D001570:Benzodiazepinones / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors*
D001570:Benzodiazepinones; D019039:Platelet Glycoprotein GPIIb-IIIa Complex