Prevention of restenosis after coronary angioplasty with low-density lipoprotein apheresis.
A prospective study was performed to determine whether low-density lipoprotein (LDL) apheresis, when performed only immediately before and after percutaneous transluminal coronary angioplasty (PTCA), is effective in preventing restenosis of coronary artery lesions following PTCA. Thirty-six patients with coronary heart disease (CHD) and hypercholesterolemia were divided into 2 groups. The 9 patients in the LDL group underwent LDL-apheresis 1 day before and 5 days after PTCA while the 27 patients of the control group underwent PTCA but did not undergo LDL-apheresis. Follow-up coronary angiography (CAG) was performed 4 months after PTCA. The rate of restenosis of coronary artery lesions was significantly lower in the LDL group (0%) than in the control group (30%). These findings suggest that LDL-apheresis, when performed before and after PTCA, is effective in preventing restenosis of coronary artery lesions in patients with CHD and hypercholesterolemia.
Adachi
H
H
Department of Medicine, Musashino Red Cross Hospital, Tokyo, Japan.
Niwa
A
A
Shinoda
T
T
D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects; D001781:Blood Component Removal; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003131:Combined Modality Therapy; D003327:Coronary Disease / Q000517:prevention & control* / Q000601:surgery; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000628:therapy*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
D008078:Cholesterol, LDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol