title: [Conservative motifs in enzyme superfamily catalyzing formation of acyladenylates and compounds with carboxy group].
abstract: The search of conserved motifs was performed in enzymes catalyzing acyladenylate formation using ATP as AMP-donor. Besides a known motif, we have found a second conserved motif. Screening the SWISS-PROT database for occurrence of the motifs have showed that both motifs are highly characteristic and occur in all proteins of this superfamily. The motifs are separated by 200-250 residues in all sequences. It may suggest that the both motifs belong to the structural unit involved in acyl adenylate formation.
authors.forename: V M
authors.initials: VM
authors.lastname: Morozov
authors.forename: N N
authors.initials: NN
authors.lastname: Ugarova
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D000595:Amino Acid Sequence; D002384:Catalysis; D017124:Conserved Sequence; D008025:Ligases / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D013379:Substrate Specificity
chemical_list: D000255:Adenosine Triphosphate; D008025:Ligases
vernacular_title: Konservativnye motivy v supersemeĭstve fermentov, kataliziruiushchikh obrazovanie atsiladenilatov iz ATP i soedineniĭ s karboksil'noĭ gruppoĭ.