title: Impairments of number processing induced by prenatal alcohol exposure.
abstract: Prenatal alcohol exposure causes a variety of cognitive deficits, notably in mathematics and higher order processes such as abstraction. An exploratory battery was developed to examine specific types of number processing impairments in 29 adolescent and adult patients with Fetal Alcohol Syndrome (FAS) and Fetal Alcohol Effects (FAE) relative to controls matched for age, gender, and educational level. The battery included 11 tests: number reading and writing, exact calculation (addition, multiplication, subtraction), approximate calculation (selecting a plausible result for an operation), number comparison, proximity judgment, and cognitive estimation. The results indicated particular difficulties in calculation and estimation tests, with intact number reading and writing ability. The greatest impairment was found in the cognitive estimation test, which is sensitive to frontal lobe lesions. The patterns of deficit described may reflect either the diffuseness of brain damage incurred from prenatal alcohol exposure, or a cumulative deficit in comprehension which may be important for the acquisition of higher-order mathematical abilities.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, Seattle 98195, USA.
authors.forename: K
authors.initials: K
authors.lastname: Kopera-Frye
authors.forename: S
authors.initials: S
authors.lastname: Dehaene
authors.forename: A P
authors.initials: AP
authors.lastname: Streissguth
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003210:Concept Formation / Q000502:physiology; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology*; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008297:Male; D008433:Mathematics; D009483:Neuropsychological Tests; D011340:Problem Solving / Q000502:physiology