title: Selective slow pathway ablation does not alter enhancement of vagal tone on sinus and atrioventricular nodal function.
abstract: We studied the effects of edrophonium on sinus cycle length, atrioventricular (AV) nodal fast pathway refractoriness, and AV nodal Wenckebach cycle length in 21 patients with AV nodal reentrant tachycardia (AVNRT) who received edrophonium, and 8 patients who received phenylephrine before and after selective slow pathway ablation. Changes in sinus cycle length, fast pathway conduction, and refractoriness were not altered by radiofrequency ablation of the slow pathway, suggesting that parasympathetic denervation does not occur after slow pathway ablation of AVNRT.
authors.affiliation: Department of Medicine (Cardiology), Medical College of Virginia and the McGuire Veterans Administration Medical Center, Richmond 23298-0053, USA.
authors.forename: M R
authors.initials: MR
authors.lastname: Olsovsky
authors.forename: M K
authors.initials: MK
authors.lastname: Belz
authors.forename: B S
authors.initials: BS
authors.lastname: Stambler
authors.forename: D M
authors.initials: DM
authors.lastname: Gilligan
authors.forename: M A
authors.initials: MA
authors.lastname: Wood
authors.forename: K A
authors.initials: KA
authors.lastname: Ellenbogen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001283:Atrioventricular Node / Q000187:drug effects / Q000294:innervation*; D017115:Catheter Ablation / Q000009:adverse effects*; D004491:Edrophonium / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000187:drug effects / Q000502:physiology; D010277:Parasympathomimetics / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011184:Postoperative Period; D012849:Sinoatrial Node / Q000187:drug effects / Q000294:innervation*; D013566:Sympathomimetics / Q000494:pharmacology; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000503:physiopathology* / Q000601:surgery*; D014630:Vagus Nerve / Q000503:physiopathology*; D061223:Vagus Nerve Injuries
chemical_list: D010277:Parasympathomimetics; D013566:Sympathomimetics; D010656:Phenylephrine; D004491:Edrophonium