Genetic mechanisms of sex differentiation.
Cloning of the SRY sex-determining locus on the Y chromosome has stimulated research on the genetic mechanisms of sex determination. It now appears that SRY is not the only gene required for testicular differentiation; X-linked and autosomal genes are also important. In parallel, mutations of genes involved in somatic sex differentiation shed light on the mechanisms involved in testis-dependent events.
Josso
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N
INSERM U. 293, Ecole Normale Supéríeur, Département de Biologie, Montrouge, France.
Rey
R
R
D006066:Gonads / Q000196:embryology; D006801:Humans; D012730:Sex Chromosomes; D012733:Sex Differentiation / Q000235:genetics*; D013739:Testosterone / Q000502:physiology
D013739:Testosterone