title: [Antibody formation after filtered blood cell replacement in hematologic-oncologic patients].
abstract: We studied the value of leucocyte depletion of platelet and erythrocyte transfusion by filter for the prevention of alloimmunization. In 109 patients with hematological diseases we detected HLA- and platelet specific antibodies by using lymphocytotoxic and IgG-EIA-Thrombomatch. In 17 of the 109 evaluable patients (16%) HLA-antibodies developed (9 female and 8 male). 16 of the 17 had only HLA-antibodies and 1 patient a platelet specific alloantibody primary immunisation. 15 of 17 with a high-risk of prior immunization induced by pregnancy or other transfusions had a 'secondary alloimmunization'.
authors.affiliation: Abteilung Transfusionsmedizin, Universität Rostock, Deutschland.
authors.forename: D
authors.initials: D
authors.lastname: Barz
authors.forename: D
authors.initials: D
authors.lastname: Staack
authors.forename: R
authors.initials: R
authors.lastname: Lehmann
authors.forename: K
authors.initials: K
authors.lastname: Stange
authors.forename: K
authors.initials: K
authors.lastname: Schnurstein
mesh_terms: D000328:Adult; D001788:Blood Grouping and Crossmatching; D004797:Enzyme-Linked Immunosorbent Assay; D017707:Erythrocyte Transfusion; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007518:Isoantibodies / Q000032:analysis*; D007938:Leukemia / Q000097:blood / Q000628:therapy*; D008212:Lymphocyte Depletion; D008223:Lymphoma / Q000097:blood / Q000628:therapy*; D008297:Male; D009369:Neoplasms / Q000097:blood / Q000628:therapy*; D017713:Platelet Transfusion; D011247:Pregnancy; D012307:Risk Factors
chemical_list: D006680:HLA Antigens; D007518:Isoantibodies
vernacular_title: Antikörperbildung nach filtriertem Blutzellersatz bei hämatologisch-onkologischen Patienten.