title: [Circadian rhythms in hepatic biotransformation of drugs].
abstract: The temporal variations in hepatic drug biotransformation are reviewed. Important diurnal variations in the activity of different cytochrome P-450 isoenzymes and in enzyme systems involved in conjugation to glucuronide, sulfate and acetate are described. A circadian rhythm in the hepatic concentration of glutathione is also described. These temporal variations explain the chronopharmacokinetic and chronohepatotoxicity of some drugs or toxic agents.
authors.affiliation: Ecole de pharmacie, Pavillon Vandry, Université Laval, Québec, Canada.
authors.forename: P M
authors.initials: PM
authors.lastname: Bélanger
mesh_terms: D000818:Animals; D001711:Biotransformation; D002940:Circadian Rhythm; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005965:Glucuronates / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008862:Microsomes, Liver / Q000201:enzymology
chemical_list: D005965:Glucuronates; D003577:Cytochrome P-450 Enzyme System; D005978:Glutathione
vernacular_title: Rythmes circadiens de la biotransformation hépatique des médicaments.