[Mechanism of the membrane stabilizing action of vitamins K and E under conditions of chronic phenol poisoning in albino rats].
In experiment with white male-rats the influence of membranotropic phenol-poison on the qualitative composition of phospholipids of liver, kidneys, heart, skeletal muscles as well as biomembranes of erythrocytes and mitochondria of liver was investigates. Along with these investigations the possibility of preventing from supposed changes of qualitative composition of phospholipids has also been studied by additional injection K and K vitamins as minor lipid components. As the result of this research it was stated that when phenol (per, os) was repeatedly injected the content of lysophospholipids, phosphatidic acids in phospholipid composition increased and the content of phosphatidylcholine, phosphatidylethanolamine and sphingomyelin simultaneous decreased. Additional injection E and K vitamins (50 mg/kg by weight and 20 mg/kg accordingly) prevented to a greater extent the changes of fractional composition of the lipid phase of biomembranes. The mechanism of protective action of K and E vitamins is probably connected with spatial screening of pi-bonds in the radicals of polyunsaturated fatty acids in phospholipid composition from reoxidation and on the hand the competitive interrelations may exist between minor lipid components and on the other hand between the ethers of cholesterol. These conclusions agree with hypothesis that K and E vitamins are the natural modifiers of the membranes of different types of structure.
Nazarov
P V
PV
Lider
V A
VA
D000818:Animals; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D007425:Intracellular Membranes / Q000187:drug effects* / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D019800:Phenol; D010636:Phenols / Q000037:antagonists & inhibitors / Q000506:poisoning*; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014810:Vitamin E / Q000494:pharmacology*; D014812:Vitamin K / Q000494:pharmacology*
D010636:Phenols; D010743:Phospholipids; D014812:Vitamin K; D014810:Vitamin E; D019800:Phenol
K mekhanizmu membranostabiliziruiushchego deĭstviia vitaminov K i E v usloviiakh khronicheskoĭ intoksikatsii belykh krys fenolom.