[Evaluation of the reagent "IL Test LAC Screen/IL Test LAC Confirm" for the biological diagnosis of circulating lupus anticoagulants].
Lupus anticoagulants (LA) are immunoglobulins which interfere with in vitro phospholipid-dependent coagulation tests. Its presence is associated with thromboembolic events. Laboratory recognition of these inhibitors is therefore of increasing clinical importance. A variety of tests has been introduced to detect LAs. In this study, 'IL Test LAC Screen/LAC Confirm', a new sensitive LA test, is evaluated on 23 LA-positive and 70 LA-negative plasmas. In this procedure, a dilute Russell's viper venom is served as a screening test with addition of phospholipids as a confirmatory test. A correct sensitivity for LAs is observed. This new approach for biological LA diagnosis may contribute to an accurate LA recognition in association with one or more phospholipid-dependent coagulation tests.
Magdelaine
A
A
Service d' hématologie biologique, höpital Tenon, Paris, France.
Verdy
E
E
D005069:Evaluation Studies as Topic; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000032:analysis*; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity
D016682:Lupus Coagulation Inhibitor; D011933:Reagent Kits, Diagnostic
Evaluation du réactif "IL Test LAC Screen/IL Test LAC Confirm" pour le diagnostic biologique des anticoagulants circulants de type lupique.