title: Genetic mechanisms of sex differentiation.
abstract: Cloning of the SRY sex-determining locus on the Y chromosome has stimulated research on the genetic mechanisms of sex determination. It now appears that SRY is not the only gene required for testicular differentiation; X-linked and autosomal genes are also important. In parallel, mutations of genes involved in somatic sex differentiation shed light on the mechanisms involved in testis-dependent events.
authors.affiliation: INSERM U. 293, Ecole Normale Supéríeur, Département de Biologie, Montrouge, France.
authors.forename: N
authors.initials: N
authors.lastname: Josso
authors.forename: R
authors.initials: R
authors.lastname: Rey
mesh_terms: D006066:Gonads / Q000196:embryology; D006801:Humans; D012730:Sex Chromosomes; D012733:Sex Differentiation / Q000235:genetics*; D013739:Testosterone / Q000502:physiology
chemical_list: D013739:Testosterone