title: [Half-time of erythropoietin in patients with chronic obstructive pulmonary diseases].
abstract: Presence of elevated plasma levels of erythropoietin (EPO) has been reported both in polycythaemic and normocythaemic patients with chronic obstructive pulmonary disease (COPD). The present study aimed to elucidate in what extent prolonged erythropoietin half-life time (T1/2EPO) is involved in the pathogenesis of elevated plasma EPO levels in patients with COPD. Seven normocythaemic patients (5 men and 2 women) with CODP and 6 healthy controls (4 males and 2 females) were examined. In all examined subjects half-life time of erythropoietin was determined after i.v. administration of EPO in a dose of 50 U/kg b.m. In COPD patients the T1/2EPO value was 5.98 +/- 0.67 hours and did not differ from that found in healthy controls (5.87 +/- 0.35 h). Results obtained in this study suggest participation of factors other than prolonged half-time of erythropoietin in the pathogenesis of polycythaemia in patients with COPD.
authors.affiliation: Kliniki Nefrologii Slaskiej, Akademii Medycznej w Katowicach.
authors.forename: E
authors.initials: E
authors.lastname: Franek
authors.forename: A
authors.initials: A
authors.lastname: Wiecek
authors.forename: J
authors.initials: J
authors.lastname: Kozielski
authors.forename: R
authors.initials: R
authors.lastname: Rauer
authors.forename: M
authors.initials: M
authors.lastname: Kokot
authors.forename: F
authors.initials: F
authors.lastname: Kokot
authors.forename: K
authors.initials: K
authors.lastname: Oklek
mesh_terms: D004921:Erythropoietin / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood*; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008173:Lung Diseases, Obstructive / Q000097:blood / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011086:Polycythemia / Q000139:chemically induced*
chemical_list: D004921:Erythropoietin