title: Monounsaturated fatty acid (avocado) rich diet for mild hypercholesterolemia.
abstract: To assess the effect of a high monounsaturated fatty acids (MFA) diet on serum lipids, 30 healthy adult normolipidemic volunteers and 37 adult patients with mild hypercholesterolemia (5.4-9.3 mmol/l), 15 of them also with hypertriglyceridemia (2.3-4.8 mmol/l), were studied. Fifteen healthy and 30 hypercholesterolemic subjects (15 of them with associated type 2 diabetes mellitus) received an avocado enriched diet (2000 Kcal, lipids 53% MFA 49 g saturated/unsaturated ratio 0.54), and seven non-diabetic hypercholesterolemic individuals received an isocaloric control diet (MFA 34 g, saturated/unsaturated ratio 0.7). Serum total cholesterol, LDL-cholesterol, HDL-cholesterol and triglyceride concentrations were measured before and after a 7-day diet period. In healthy individuals a 16% decrease of serum total cholesterol level followed the high MFA diet, while it rose after the control diet (p < 0.001 between diets). In hypercholesterolemic subjects a significant (p < 0.01) decrease of serum total cholesterol (17%), LDL-cholesterol (22%) and triglycerides (22%), and increase of HDL-cholesterol (11%) levels occurred with the avocado diet, while no significant changes were noticed with the control diet. High lipid, high MFA-avocado enriched diet can improve lipid profile in healthy and especially in mild hypercholesterolemic patients, even if hypertriglyceridemia (combined hyperlipidemia) is present.
authors.affiliation: División de Enseñanza e Investigación, Centro Médico La Raza, Instituto Mexicano del Seguro Social, México, D.F.
authors.forename: R
authors.initials: R
authors.lastname: López Ledesma
authors.forename: A C
authors.initials: AC
authors.lastname: Frati Munari
authors.forename: B C
authors.initials: BC
authors.lastname: Hernández Domínguez
authors.forename: S
authors.initials: S
authors.lastname: Cervantes Montalvo
authors.forename: M H
authors.initials: MH
authors.lastname: Hernández Luna
authors.forename: C
authors.initials: C
authors.lastname: Juárez
authors.forename: S
authors.initials: S
authors.lastname: Morán Lira
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003920:Diabetes Mellitus / Q000178:diet therapy; D004042:Dietary Fats, Unsaturated; D005229:Fatty Acids, Monounsaturated / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000178:diet therapy*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004042:Dietary Fats, Unsaturated; D005229:Fatty Acids, Monounsaturated; D014280:Triglycerides; D002784:Cholesterol