Synthesis of indole-N-propionitrile, N-propionic acid and N-propionamide derivatives of potential biological activity.
Cyanoethylation of a selected group from indole derivatives 1a-i using acrylonitrile in pyridine and potassium hydroxide afforded the corresponding indole-1-propionitrile 2a-h derivatives which readily hydrolysed in basic medium to the corresponding indole-1-propionic acid derivatives 4a-c. A several attempts to cyclize the above products-to the corresponding dihydropyrroloquinolin-4-one derivatives. The indole-1-propionamide derivatives reacted with diethyl carbonate and ethyl acetate under Claisen condensation also, with diazonium salts and nitric acid.
El-Desokey
S I
SI
Faculty of science, Mansoura University, Egypt.
Hammad
M
M
Grant
N
N
El-Telbany
E M
EM
Abdel Rahman
A H
AH
D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009570:Nitriles / Q000138:chemical synthesis* / Q000494:pharmacology; D011422:Propionates / Q000138:chemical synthesis* / Q000494:pharmacology
D000577:Amides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D009570:Nitriles; D011422:Propionates