title: Antiplatelet arylnaphthalide lignans from Justicia procumbens.
abstract: Fractionation of the EtOH extract of Justicia procumbens, guided by antiplatelet bioassay, led to the isolation of nine known arylnaphthalide lignans, neojusticin A (1), justicidin B (2), justicidin A (3), taiwanin E methyl ether (4), neojusticin B (5), chinensinaphthol methyl ether (6), taiwanin E (8), chinensinaphthol (9), and diphyllin (10), and a new arylnaphthalide lignan that was characterized by spectral means as 4'-demethylchinensinaphthol methyl ether (7). Compounds 1, 2, 4, and 8 significantly inhibited platelet aggregation.
authors.affiliation: National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China.
authors.forename: C C
authors.initials: CC
authors.lastname: Chen
authors.forename: W C
authors.initials: WC
authors.lastname: Hsin
authors.forename: F N
authors.initials: FN
authors.lastname: Ko
authors.forename: Y L
authors.initials: YL
authors.lastname: Huang
authors.forename: J C
authors.initials: JC
authors.lastname: Ou
authors.forename: C M
authors.initials: CM
authors.lastname: Teng
mesh_terms: D000818:Animals; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009281:Naphthalenes / Q000302:isolation & purification* / Q000494:pharmacology; D009391:Nephelometry and Turbidimetry; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D011817:Rabbits; D013055:Spectrophotometry, Infrared
chemical_list: D009281:Naphthalenes; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors