Development of mupirocin resistance among methicillin-resistant Staphylococcus aureus after widespread use of nasal mupirocin ointment.
All methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from colonized or infected patients in a 625-bed public teaching hospital during an epidemic, and for 3 years thereafter, underwent susceptibility testing to mupirocin. Mupirocin resistance among MRSA increased markedly over this period (1990, 2.7%; 1991, 8.0%; 1992, 61.5%; 1993, 65%) in association with increased use of mupirocin ointment as an adjunct to infection control measures.
Miller
M A
MA
Department of Microbiology, SMBD-Jewish General Hospital, Montreal, Quebec, Canada.
Dascal
A
A
Portnoy
J
J
Mendelson
J
J
D000281:Administration, Intranasal; D000900:Anti-Bacterial Agents; D003428:Cross Infection / Q000188:drug therapy* / Q000382:microbiology; D004352:Drug Resistance, Microbial; D006801:Humans; D017053:Infection Control; D016106:Methicillin Resistance; D016712:Mupirocin; D015995:Prevalence; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus
D000900:Anti-Bacterial Agents; D016712:Mupirocin