FDG-PET evaluation of retroperitoneal metastases of testicular cancer before and after chemotherapy.
We describe a patient whose primary tumor was a testicular teratocarcinoma predominantly composed of embryonal carcinoma. Before chemotherapy, the retroperitoneal metastases demonstrated heterogeneous, increased glucose metabolism as measured by 2-[18F]fluoro-2-deoxy-D-glucose and PET (FDG-PET). After chemotherapy, FDG uptake was reduced to normal values despite increased tumor volume. Histology revealed a pure mature teratoma. This observation suggests that further studies are needed to determine whether tumor differentiation of testicular teratocarcinoma metastases can be assessed by measuring glucose metabolism.
Reinhardt
M J
MJ
Department of Nuclear Medicine, Heinrich-Heine-University of Düsseldorf, Medical School, Germany.
Müller-Mattheis
V G
VG
Gerharz
C D
CD
Vosberg
H R
HR
Ackermann
R
R
Müller-Gärtner
H W
HW
D000328:Adult; D018236:Carcinoma, Embryonal / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism / Q000556:secondary*; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D012186:Retroperitoneal Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism / Q000556:secondary*; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000378:metabolism; D014055:Tomography, Emission-Computed / Q000379:methods*
D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose