title: Activity of third generation cephalosporins against Pseudomonas aeruginosa in high risk hospital units.
abstract: Ceftazidime and Cefoperazone are the two third generation cephalosporins with anti-pseudomonal activity. They have been frequently used in the I.C.U.s. in the developed countries but their use in the Indian hospitals has begun relatively recently. We studied the in-vitro susceptibility of 139 Pseudomonas aeruginosa isolates that were multiple drug resistant from the Resuscitation Unit/I.C.U. (61 strains), Burns Unit (48 strains), Surgical Post-operative unit (24 strains), Nephrology unit (6 strains) of our hospital to these two cephalosporine over a period of about 18 months. Antibiotic susceptibility was studied using Kirby Bauer's disc dibusion method. Out of a total of 139 strains of multiple drug resistant Pseudomonas aeruginosa tested, 17.9% were found resistant each to Ceftazidime and Cefoperazone separately and 10% were found resistant to both antibiotics.
authors.affiliation: Dept. of Microbiology, University College of Medical Sciences, Delhi.
authors.forename: J
authors.initials: J
authors.lastname: Puri
authors.forename: G
authors.initials: G
authors.lastname: Revathi
authors.forename: P
authors.initials: P
authors.lastname: Kundra
authors.forename: V
authors.initials: V
authors.lastname: Talwar
mesh_terms: D002511:Cephalosporins / Q000494:pharmacology*; D003428:Cross Infection / Q000382:microbiology; D004352:Drug Resistance, Microbial; D006757:Hospital Units; D006801:Humans; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012307:Risk Factors
chemical_list: D002511:Cephalosporins