Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. CI-1011: an acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets.
Lee
H T
HT
Department of Medicinal Chemistry, Radiochemistry, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, Michigan 48105, USA.
Sliskovic
D R
DR
Picard
J A
JA
Roth
B D
BD
Wierenga
W
W
Hicks
J L
JL
Bousley
R F
RF
Hamelehle
K L
KL
Homan
R
R
Speyer
C
C
Stanfield
R L
RL
Krause
B R
BR
D000081:Acetamides; D000085:Acetates; D000818:Animals; D000924:Anticholesteremic Agents / Q000737:chemistry / Q000494:pharmacology*; D004032:Diet; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*; D013449:Sulfonamides; D013451:Sulfonic Acids / Q000737:chemistry / Q000494:pharmacology*
D000081:Acetamides; D000085:Acetates; D000924:Anticholesteremic Agents; D004791:Enzyme Inhibitors; D013449:Sulfonamides; D013451:Sulfonic Acids; C423185:avasimibe; D002785:Sterol O-Acyltransferase