Perspectives on immunotoxicity regulatory guidelines.
The regulatory guidelines relating to testing for immunotoxicity are not harmonised amongst the various agencies. This paper outlines the current situation within Europe, Japan and the USA. The agencies within the USA representing both agrochemicals and food additives are the most demanding in their requirements, and these guidelines are currently used as the definitive requirements for the testing of compounds for immunotoxicity.
Harling
R J
RJ
Pharmaceutical Services, Huntingdon Life Sciences Ltd., Cambridgeshire, UK.
D016573:Agrochemicals / Q000592:standards; D000941:Antigens / Q000276:immunology; D005060:Europe; D005503:Food Additives / Q000592:standards; D017408:Guidelines as Topic; D006801:Humans; D006968:Hypersensitivity, Delayed; D000922:Immunotoxins / Q000276:immunology / Q000633:toxicity; D007564:Japan; D007880:Legislation, Drug; D007881:Legislation, Food; D014481:United States; D014484:United States Environmental Protection Agency; D014486:United States Food and Drug Administration
D016573:Agrochemicals; D000941:Antigens; D005503:Food Additives; D000922:Immunotoxins