Inhibition of histamine release by nedocromil sodium reduces exercise-induced hypoxemia in master athletes.
During exercise in highly-trained older master athletes (MA), the impairment of pulmonary gas exchanges has been shown to be associated with a concomitant increase in histamine release (2). To determine the role of the histamine released (% H) during exercise-induced hypoxemia, seven MA (age 63.2 yr +/- 1.9), all of whom were known to develop exercise-induced hypoxemia, performed two maximal incremental exercise tests at a one-month interval after administration of nedocromil sodium (which inhibits histamine and other mediator release) or placebo in random double-blind order. During exercise testing, blood samples for arterial blood gas analysis and histamine assay were drawn at rest, exercise and recovery. Nedocromil sodium induced an inhibition in % H (0.57 +/- 0.03 at maximal load (Pmax) with placebo vs 0.24 +/- 0.02 with nedocromil sodium) linked with an improvement of pulmonary gas exchange (PaO2: 71.1 +/- 1.4 at Pmax with placebo vs 83.4 +/- 3 with nedocromil sodium; D(Ai-a)O2: 37.5 +/- 1.4 at Pmax vs 19.1 +/- 3.1, respectively). These results confirm the link established between the increase in histamine and exercise-induced hypoxemia in master athletes.
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Laboratoire de Physiologie des Interactions, Hopital Arnaud de Villeneuve, Montellier, France.
Anselme-Poujol
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Caillaud
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D000368:Aged; D000375:Aging / Q000502:physiology*; D004311:Double-Blind Method; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006632:Histamine / Q000097:blood; D006633:Histamine Antagonists / Q000494:pharmacology*; D006801:Humans; D000860:Hypoxia / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D017835:Nedocromil / Q000494:pharmacology*; D011659:Pulmonary Gas Exchange
D006633:Histamine Antagonists; D017835:Nedocromil; D006632:Histamine