Use of recombinant human growth hormone (rhGH) in pubertal patients with CRI/dialysis/post-transplant: Dutch data. Dutch Study Group on Growth in Children with Chronic Renal Disease.
In the intermediate term, recombinant human growth hormone (rhGH) therapy in a dose of 28-30 i.u./m2/week accelerates growth significantly in most pubertal patients with growth retardation secondary to chronic renal insufficiency (CRI), dialysis and after renal transplantation (RTx), without evidence of adverse effects or acceleration of bone maturation. Therefore, rhGH therapy may well improve the final height of these patients.
Hokken-Koelega
A C
AC
Department of Pediatrics, Sophia Children's Hospital, Erasmus University, Rotterdam, The Netherlands.
de Jong
R C
RC
Donckerwolcke
R A
RA
Groothoff
J W
JW
Wolff
E D
ED
D000293:Adolescent; D005260:Female; D006128:Growth / Q000187:drug effects; D006130:Growth Disorders / Q000188:drug therapy* / Q000209:etiology*; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D016030:Kidney Transplantation; D008297:Male; D011184:Postoperative Period; D006435:Renal Dialysis
D019382:Human Growth Hormone