Exophilin A, a new antibiotic from a marine microorganism Exophiala pisciphila.
Exophilin A, a new antibacterial compound, was discovered in the culture of the marine microorganism Exophiala pisciphila NI10102, which was isolated from a marine sponge Mycale adhaerens. The absolute chemical structure of exophilin A was elucidated as a trimer of (3R,5R)-3,5-dihydroxydecanoic acid by spectroscopic methods and analyses of a degradative product. Exophilin A showed antimicrobial activity against Gram-positive bacteria.
Doshida
J
J
Central Research Laboratory, Nippon Suisan Kaisha, Ltd., Tokyo, Japan.
Hasegawa
H
H
Onuki
H
H
Shimidzu
N
N
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003651:Decanoates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D003651:Decanoates; C103160:exophilin A