title: Early ontogeny of immune cells and their functions in the fetal pig.
abstract: The origin of immune cells and their products have been studied in the prenatal period in miniature pigs. Macrophages were first detected on day 25, and myelocytes and lymphoid cells by day 28. Membrane antigens SLA-DR and CD45 were found by day 22, membrane molecules MG-7, 8/1, CD1, CD2 and 74-22 by day 28, Gamma/delta T cells were found initially in extrathymic sites (in the liver). The first gamma/delta T cells were detected as early as 40 days of gestation. The expression of fibronectin, Thy-1 and its message, Ig isotypes and the first induction of IFN alpha were described.
authors.affiliation: Dept. Immunology and Gnotobiology, Novy Hrádek Prague Czech Republic.
authors.forename: I
authors.initials: I
authors.lastname: Trebichavský
authors.forename: H
authors.initials: H
authors.lastname: Tlaskalová
authors.forename: B
authors.initials: B
authors.lastname: Cukrowska
authors.forename: I
authors.initials: I
authors.lastname: Splíchal
authors.forename: J
authors.initials: J
authors.lastname: Sinkora
authors.forename: Z
authors.initials: Z
authors.lastname: Oeháková
authors.forename: M
authors.initials: M
authors.lastname: Sinkora
authors.forename: R
authors.initials: R
authors.lastname: Pospísil
authors.forename: F
authors.initials: F
authors.lastname: Kováøù
authors.forename: B
authors.initials: B
authors.lastname: Charley
authors.forename: R
authors.initials: R
authors.lastname: Binns
authors.forename: A
authors.initials: A
authors.lastname: White
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D005314:Embryonic and Fetal Development / Q000276:immunology*; D006098:Granulocytes / Q000276:immunology; D007107:Immune System / Q000166:cytology* / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D013552:Swine