title: Gastrointestinal actions of buprenorphine: are different receptors involved?
abstract: The effects of buprenorphine on castor-oil-induced diarrhoea, gastrointestinal transit and ethanol-induced gastric lesions in rats were compared to the same effects of morphine. Like morphine, buprenorphine prevented castor-oil-induced diarrhoea. However, it has no effect on gastrointestinal transit per se but prevented the inhibitory action of morphine. While morphine protected against ethanol-induced gastric lesions, buprenorphine aggravated them. It is suggested that different types/subtypes of opioid receptors may be involved in the gastrointestinal actions of buprenorphine.
authors.affiliation: Department of Pharmacology, Goa Medical College, India.
authors.forename: S A
authors.initials: SA
authors.lastname: Bhounsule
authors.forename: S
authors.initials: S
authors.lastname: D'Sa
authors.forename: N
authors.initials: N
authors.lastname: Fernandes
authors.forename: R D
authors.initials: RD
authors.lastname: D'Souza
authors.forename: V G
authors.initials: VG
authors.lastname: Dhume
mesh_terms: D000818:Animals; D002047:Buprenorphine / Q000494:pharmacology*; D003967:Diarrhea / Q000188:drug therapy*; D004064:Digestive System / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D009270:Naloxone; D002047:Buprenorphine; D009020:Morphine