Pharmacokinetic studies of 131I-stevioside and its metabolites.
131I-STEVIOSIDE (1.10 MBq) was injected i.v in Wistar male rats, in distribution in the body and metabolism were studied. The highest concentration of radioactivity was observed in the liver and in the small intestine after 10 and 120 minutes, respectively. At 2 h after injection, the radioactivity eliminated in the bile was 52.0% of the original dose. The results of RP-HPLC analysis of the bile showed that stevioside was degraded in vivo and that steviol appeared as a major metabolite. However, in the urine; RP-HPLC analysis did not show the presence of steviol.
Cardoso
V N
VN
Food Department, Faculty of Pharmacy/UFMG, São Paulo, Brazil.
Barbosa
M F
MF
Muramoto
E
E
Mesquita
C H
CH
Almeida
M A
MA
D000818:Animals; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000378:metabolism; D045786:Diterpenes, Kaurane; D005243:Feces / Q000737:chemistry; D005960:Glucosides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D007457:Iodine Radioisotopes; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013729:Terpenes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D004224:Diterpenes; D045786:Diterpenes, Kaurane; D005960:Glucosides; D007457:Iodine Radioisotopes; D013729:Terpenes; C012043:stevioside; C012042:steviol