title: Two year old hepatitis A vaccine is as good as new.
abstract: This was a randomized, controlled, double-blind study assessing the reactogenicity and immunogenicity of newly produced vs 2 year old hepatitis A vaccine. Overall 215 non-immune volunteers, 18-39 years old were divided into four groups and administered vaccine at months 0, 1 and 6. Three groups each received a different vaccine lot which had been stored at 4 degrees C for 2 years, and one group received recently produced vaccine as control. The mean local and general adverse reaction rates were 59.1% and 17.4%, respectively, and all vaccinees had seroconverted by month 2. There were no significant differences in geometric mean anti-hepatitis A virus (HAV) antibody titres between the four groups. In conclusion 2 year old HAV vaccine is safe and equally immunogenic as newly produced vaccine.
authors.affiliation: Department of Medicine, Royal College of Surgeons, Dublin, Ireland.
authors.forename: E
authors.initials: E
authors.lastname: Rajan
authors.forename: S
authors.initials: S
authors.lastname: al Bloushi
authors.forename: B
authors.initials: B
authors.lastname: O'Farrell
authors.forename: A
authors.initials: A
authors.lastname: Shattock
authors.forename: M G
authors.initials: MG
authors.lastname: Courtney
authors.forename: A
authors.initials: A
authors.lastname: Safary
authors.forename: J F
authors.initials: JF
authors.lastname: Fielding
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D004311:Double-Blind Method; D004355:Drug Stability; D005260:Female; D022362:Hepatitis A Vaccines; D006507:Hepatovirus; D006801:Humans; D008297:Male; D010146:Pain / Q000209:etiology; D014761:Viral Hepatitis Vaccines / Q000009:adverse effects / Q000276:immunology* / Q000627:therapeutic use
chemical_list: D000914:Antibodies, Viral; D022362:Hepatitis A Vaccines; D014761:Viral Hepatitis Vaccines