Vasculyne, a new cytotoxic acetylenic alcohol from the marine sponge Cribrochalina vasculum.
A new C43 acetylenic alcohol, vasculyne (1), was isolated by cytotoxicity-guided fractionation of the Caribbean sponge Cribrochalina vasculum. The structure of 1 was determined by spectroscopic methods.
Dai
J R
JR
Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment, Diagnosis, and Centers, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
Hallock
Y F
YF
Cardellina
J H
JH
Boyd
M R
MR
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D005233:Fatty Alcohols / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D005233:Fatty Alcohols; C102618:vasculyne