Preventing Rhesus D haemolytic disease of the newborn by giving anti-D immunoglobulin: are the guidelines being adequately followed?
OBJECTIVE
To ascertain whether anti-D immunoglobulin is being administered to Rhesus D negative women in accordance with the 1991 recommendations for its use to cover all events which may result in fetomaternal haemorrhage.


METHODS
The notes of women delivered in 1994 were examined for compliance with the 1991 recommendations.


METHODS
Seven maternity units using a central antenatal screening service.


METHODS
Nine hundred and twenty-two Rhesus D negative women delivered in these seven hospitals.


METHODS
The prescription, dosage and indications for administration of anti-D immunoglobulin to women during pregnancy and in the puerperium.


RESULTS
Postnatal anti-D immunoglobulin was given in appropriate doses to more than 95% of women who required it. Omissions mainly arose from confusion among women who recently had received antenatal treatment with anti-D immunoglobulin. The 1991 recommendations for antenatal administration were less closely followed. Abdominal trauma was covered in only 20% of cases. An inadequate dosage of 250 i.u. was given to 25 women for antepartum haemorrhage after 20 weeks of gestation. The purpose of the Kleihauer test was sometimes poorly understood, with a 'negative' result interpreted as a reason not to give anti-D immunoglobulin.


CONCLUSIONS
Closer adherence to the 1991 recommendations might further reduce the incidence of Rhesus D immunisation below the current 1%. It is suggested that more careful application of the recommendations should be evaluated before considering either routine antenatal prophylaxis, or the European recommendation of a larger dose (1000-1500 i.u.), both of which would increase the requirements for this limited resource.
Howard
H L
HL
Mersey and North Wales Blood Centre, Liverpool, UK.
Martlew
V J
VJ
McFadyen
I R
IR
Clarke
C A
CA
D004899:Erythroblastosis, Fetal / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000008:administration & dosage*; D008431:Maternal-Fetal Exchange; D011181:Postnatal Care; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011295:Prenatal Care; D012203:Rh Isoimmunization / Q000628:therapy*; D018029:Rho(D) Immune Globulin; D013997:Time Factors
D007518:Isoantibodies; C061961:RHO(D) antibody; D018029:Rho(D) Immune Globulin