title: Cryptococcus neoformans var. gattii among patients with cryptococcal meningitis in Mexico. First observations.
abstract: A retrospective study of 20 patients with cryptococcal meningitis and their isolated strains was performed. Cryptococcus neoformans var. neoformans was recovered from 14 (70%) cases, and var. gattii was recovered from six (30%) patients. Twelve patients had AIDS (all carrying var. neoformans), two had other diseases (one with var. neoformans and one var. gattii) and there was no identifiable underlying disease in six (one var. neoformans and five var. gattii). Fourteen patients (11 var. neoformans and three var. gattii) resided in the Mexico City area, where a temperate climate is prevalent, and there were six cases (three var. neoformans and three var. gattii) from states with a tropical/subtropical climate. Although there was no significant statistical difference between the two varieties, the fatal outcome was higher in patients with var. neoformans. The disease caused by var. gattii strains was characterized by a higher opening pressure, more inflamatory changes of CSF and a longer clinical course (delayed clinical and mycological cure). Cryptococcus neoformans var. gattii is a significant cause of cryptococcal meningitis in patients without underlying diseases in Mexico.
authors.affiliation: Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F.
authors.forename: R
authors.initials: R
authors.lastname: López-Martínez
authors.forename: J L
authors.initials: JL
authors.lastname: Soto-Hernández
authors.forename: L
authors.initials: L
authors.lastname: Ostrosky-Zeichner
authors.forename: L R
authors.initials: LR
authors.lastname: Castanón-Olivares
authors.forename: V
authors.initials: V
authors.lastname: Angeles-Morales
authors.forename: J
authors.initials: J
authors.lastname: Sotelo
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000134:cerebrospinal fluid / Q000453:epidemiology* / Q000382:microbiology; D000328:Adult; D000368:Aged; D002980:Climate; D003455:Cryptococcus neoformans / Q000145:classification / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D008297:Male; D016919:Meningitis, Cryptococcal / Q000134:cerebrospinal fluid / Q000453:epidemiology* / Q000382:microbiology; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D016533:Mycological Typing Techniques; D012189:Retrospective Studies