Intramyelinic edema in chronic inflammatory demyelinating polyneuropathy.
We describe a patient affected by chronic inflammatory demyelinating polyneuropathy (CIDP) whose sural nerve biopsy revealed a marked edema of the myelin sheath. Since this change has been previously described in human peripheral nerves only in CIDP patients, we suggest that intramyelinic edema may have a role in the pathogenesis of demyelinating neuropathies.
Sabatelli
M
M
Neurological Institute and UILDM, Catholic University, Rome, Italy.
Mignogna
T
T
Lippi
G
G
Porcu
C
C
Tonali
P
P
D001706:Biopsy; D002908:Chronic Disease; D003711:Demyelinating Diseases / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D004487:Edema / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009186:Myelin Sheath / Q000473:pathology*; D009443:Neuritis / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D010523:Peripheral Nervous System Diseases / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D013497:Sural Nerve / Q000473:pathology*