[Control mechanisms of cell transition from the G1 phase to the S phase--the R point].
The critical moment of regulation when transition of the cell from the G1 to the S phase takes which is decisive for its division is the so-called R-point (restriction point). The disorder of molecular mechanisms controlling the passage of the cell through this site is an associated manifestation of most tumourous processes. A considerable part of this mechanism is the RB protein, binding transcription factors needed for the activation of genes effective in the S phase. Its binding capacity depends on the extent of phosphorylation and on the activity of the appropriate kinases and their inhibitors.
Bártek
J
J
Danish Cancer Soc., Div. Tumor Biol., Copenhagen.
Lukás
L
L
Strauss
M
M
D018844:Cyclin-Dependent Kinases / Q000502:physiology; D016213:Cyclins / Q000502:physiology; D016193:G1 Phase / Q000502:physiology*; D005786:Gene Expression Regulation; D016160:Retinoblastoma Protein / Q000502:physiology; D016196:S Phase / Q000502:physiology*
D016213:Cyclins; D016160:Retinoblastoma Protein; D018844:Cyclin-Dependent Kinases