title: Mice expressing activated CaMKII lack low frequency LTP and do not form stable place cells in the CA1 region of the hippocampus.
abstract: To relate different forms of synaptic plasticity to the formation and maintenance of place cells in the hippocampus, we have recorded place cells in freely behaving, transgenic mice that express a mutated Ca2+-independent form of CaM Kinase II. These mice have normal long-term potentiation (LTP) at 100 Hz, but they lack LTP in response to stimulation at 5-10 Hz and are impaired on spatial memory tasks. In these transgenic mice, the place cells in the CA1 region have three important differences from those of wild types: they are less common, less precise, and less stable. These findings suggest that LTP in the 5-10 Hz range may be important for the maintenance of place-field stability and that this stability may be essential for the storage of spatial memory.
authors.affiliation: SUNY Downstate Medical Center, Department of Physiology, Brooklyn, New York 11203, USA.
authors.forename: A
authors.initials: A
authors.lastname: Rotenberg
authors.forename: M
authors.initials: M
authors.lastname: Mayford
authors.forename: R D
authors.initials: RD
authors.lastname: Hawkins
authors.forename: E R
authors.initials: ER
authors.lastname: Kandel
authors.forename: R U
authors.initials: RU
authors.lastname: Muller
mesh_terms: D000200:Action Potentials; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001931:Brain Mapping; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000502:physiology*; D003071:Cognition / Q000502:physiology; D006624:Hippocampus / Q000502:physiology*; D017774:Long-Term Potentiation; D008568:Memory / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D009473:Neuronal Plasticity; D013028:Space Perception / Q000502:physiology*; D013569:Synapses / Q000502:physiology
chemical_list: D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases