title: Synthesis and tumor inhibiting activity of lanthanum (III) complexes with some 1-aminocycloalkancarboxylic acids.
abstract: Complexes of La(III) with 1-aminocyclopentane-, -hexane, -heptane and -4-ethylcyclohexanecarboxylic acids were obtained. The compounds were characterized by elemental analyses, IR spectroscopy and conductivity measurements. The following general formula was derived: LaL3Cl3 x 5 H2O, where L is the corresponding 1-aminocycloalkanecarboxylic acid. The pharmacological studies showed that all complexes manifested higher cytostatic and cytotoxic effects in comparison with lanthanum chloride. Much higher cytotoxic (anti-P388/D1) and cytostatic (anti-L-1210 and anti-melanoma-B16) activity was found for the lanthanum complex with 1-aminocyclopentanecarboxylic acid.
authors.affiliation: Department of Chemistry, Higher Medical School, Sofia, Bulgaria.
authors.forename: T B
authors.initials: TB
authors.lastname: Kovachev
authors.forename: D S
authors.initials: DS
authors.lastname: Ivanov
authors.forename: R T
authors.initials: RT
authors.lastname: Buyukliev
authors.forename: S M
authors.initials: SM
authors.lastname: Konstantinov
authors.forename: M C
authors.initials: MC
authors.lastname: Karaivanova
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007811:Lanthanum / Q000494:pharmacology; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D008024:Ligands; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D008024:Ligands; D009942:Organometallic Compounds; D007811:Lanthanum