Drug delivery issues in vaccine development.
Although significant headway has been made in vaccine development, there are several delivery-related issues that must be overcome to advance tomorrow's candidate vaccines. Some of these are in the areas of: single-shot subunit vaccines, therapeutic vaccines for cancer, the use of cytokines as vaccine adjuvants, DNA-based vaccines, and the development of vaccines that provide sterilizing immunity, as might be required for an affective HIV-1 prophylactic vaccine. The hurdles for vaccine advancement in these areas are briefly described.
Powell
M F
MF
Genentech, Inc., South San Francisco, California 94080, USA.
D016915:AIDS Vaccines / Q000008:administration & dosage; D000818:Animals; D019496:Cancer Vaccines / Q000008:administration & dosage; D016207:Cytokines / Q000008:administration & dosage; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D004355:Drug Stability; D006801:Humans; D007114:Immunization / Q000379:methods; D014612:Vaccines / Q000008:administration & dosage*; D019444:Vaccines, DNA / Q000008:administration & dosage; D014614:Vaccines, Synthetic / Q000008:administration & dosage
D016915:AIDS Vaccines; D019496:Cancer Vaccines; D016207:Cytokines; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D014612:Vaccines; D019444:Vaccines, DNA; D014614:Vaccines, Synthetic