Bone growth: coordinating chondrocyte differentiation.
Two signalling molecules-Indian hedgehog and parathyroid hormone-related peptide-have been found to function in a negative feedback loop that is crucial for the coordinated regulation of the rate and extent of endochondral bone growth.
Wallis
G A
GA
School of Biological Sciences, University of Manchester, UK.
D000818:Animals; D001846:Bone Development; D002356:Cartilage / Q000196:embryology / Q000378:metabolism; D002454:Cell Differentiation; D002455:Cell Division; D006132:Growth Plate / Q000166:cytology / Q000378:metabolism; D053823:Hedgehog Proteins; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D018016:Receptors, Parathyroid Hormone / Q000378:metabolism; D015534:Trans-Activators
D053823:Hedgehog Proteins; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins; D018016:Receptors, Parathyroid Hormone; D015534:Trans-Activators