[Production of tumor necrosis factor-alpha and interleukin-1 beta in patients with pulmonary tuberculosis in relation to the course of a process and immunological features].
The production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) by peripheral mononuclears induced by prodigiosane, tuberculin, phytohemagglutinin and unduced and the serum levels of the above cytokines were studied. There was an relationship between the production of TNF-alpha in the patients' peripheral blood and the type and pattern of a tuberculosis process. The similar tendencies were found in the production of IL-1 beta. It was found that the production of IL-1 beta was higher in patients with a more predominant humoral immune response and that of TNF-alpha was greater in those with a more cellular response. There were the most marked relationships of cytokine synthesis to the degree of clinical parameters in prodigiosan cell induction of cells and to immunological parameters in tuberculin-induced cell stimulation.
Knoring
B E
BE
NII Phthisiopulmonology, Saint-Petersburg, Russian Federation.
Simbirtsev
A S
AS
Sakharova
I I
II
Kotov
A I
AI
D015415:Biomarkers / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D013601:T-Lymphocytes / Q000378:metabolism*; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D015415:Biomarkers; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha