Cell cycle: on target with Myc.
Recent evidence indicates that the c-Myc proto-oncogene activates transcription of cdc25A. The Cdc25A protein phosphatase is required both for progression through mitosis and for Myc-induced apoptosis, making cdc25A the most attractive Myc target gene identified so far.
Zörnig
M
M
Biochemistry of the Cell Nucleus Laboratory, Imperial Cancer Research Fund Laboratories, London, UK.
Evan
G I
GI
D000818:Animals; D017209:Apoptosis; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000235:genetics*; D005786:Gene Expression Regulation; D018257:Helix-Loop-Helix Motifs; D006801:Humans; D016350:Leucine Zippers; D010749:Phosphoprotein Phosphatases / Q000235:genetics*; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics* / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics* / Q000378:metabolism; D020687:cdc25 Phosphatases
D018797:Cell Cycle Proteins; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc; D015534:Trans-Activators; D010749:Phosphoprotein Phosphatases; D020687:cdc25 Phosphatases