title: Effect of age on blood acid-base composition in adult humans: role of age-related renal functional decline.
abstract: In 64 apparently healthy adult humans (ages 17-74 yr) ingesting controlled diets, we investigated the separate and combined effects of age, glomerular filtration rate (GFR, index of age-related renal functional decline), renal net acid excretion [NAE, index of endogenous acid production (EAP)], and blood PCO2 (PbCO2, index of respiratory set point) on steady-state blood hydrogen ion ([H+]b) and plasma bicarbonate concentration ([HCO3-]p). Independent predictors of [H+]b and [HCO3-]p were PbCO2, NAE, and either age or GFR, but not both, because the two were highly correlated (inversely). [H+]b increased with increasing PbCO2, NAE, and age and with decreasing GFR. [HCO3-]p decreased with increasing NAE and age but increased with increasing PbCO2 and GFR. Age (or GFR) at constant NAE had greater effect on both [H+]b and [HCO3-]p than did NAE at constant age (or GFR). Neither PbCO2 nor NAE correlated with age or GFR. Thus two metabolic factors, diet-dependent EAP and age (or GFR), operate independently to determine blood acid-base composition in adult humans. Otherwise healthy adults manifest a low-grade diet-dependent metabolic acidosis, the severity of which increases with age at constant EAP, apparently due in part to the normal age-related decline of renal function.
authors.affiliation: Department of Medicine, University of California, San Francisco 94143, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Frassetto
authors.forename: R C
authors.initials: RC
authors.lastname: Morris
authors.forename: A
authors.initials: A
authors.lastname: Sebastian
mesh_terms: D000136:Acid-Base Equilibrium; D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood* / Q000502:physiology*; D001639:Bicarbonates / Q000097:blood; D002245:Carbon Dioxide / Q000097:blood; D002712:Chlorides / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006859:Hydrogen / Q000097:blood; D007668:Kidney / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010313:Partial Pressure; D011522:Protons
chemical_list: D001639:Bicarbonates; D002712:Chlorides; D011522:Protons; D002245:Carbon Dioxide; D006859:Hydrogen