Visualization of lCBF changes during cortical infarction using IR thermo-encephaloscopy.
Infrared thermo-encephaloscopy (IR-TE) was used for two-dimensional imaging of local cortical blood flow (lCBF) with high spatio-temporal resolution. The basis of this method is the transfer of thermal energy from circulating blood to cortical tissue depending on local perfusion. Temperature fields that emerge from differences in lCBF can be measured with a high resolution thermo-scanner. Infarctions 2 mm in diameter were produced by photochemically induced thrombosis and IR-TE was used to visualize lCBF changes in and around the focal infarction. The infarcted region was characterized by a lower temperature (0.1-0.3 K) than that of the surrounding tissue. In addition to the visualization of persistent blood flow changes it was possible to detect dynamic lCBF changes that might correlate with long-lasting hyperaemia and episodes of cortical spreading depression (SD).
Rausch
M
M
Abteilung für Neurophysiologie, Medizinische Fakultät, Ruhr-Universität Bochum, Germany.
Eysel
U T
UT
D000818:Animals; D002544:Cerebral Infarction / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004195:Disease Models, Animal; D007035:Hypothermia / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D013055:Spectrophotometry, Infrared