Central nervous system involvement at diagnosis in a case of pediatric CD30+ anaplastic large cell lymphoma.
Central nervous system (CNS) involvement in Ki-1/CD30 lymphoma is extremely rare, in contrast to the frequent involvement in other types of pediatric non-Hodgkin's lymphoma. No mechanism has yet been proposed to explain the sparing of the blood brain barrier in Ki-1/lymphoma. We present a 2-year-old boy who was admitted to the Department of Pediatric Hemato-Oncology due to lethargy, progressive breathing difficulties, massive diffuse lymphadenopathy, hepatosplenomegaly, and ichthyosis-like skin involvement with epidermolysis. A lymph node biopsy was compatible with Ki-1/CD30 anaplastic large cell lymphoma (ALCL). Bone marrow aspirate and biopsy demonstrated reactive hyperplasia. Cytogenetic analysis displayed hyperdiploid cells with 1p(-) in most cells. Cerebrospinal fluid examination showed pleocytosis with CD30+ cells. Possible mechanisms which could enable CNS involvement in this unusual case are discussed.
Kaplinsky
C
C
Department of Pediatric Hemato-Oncology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Toren
A
A
Neumann
Y
Y
Mandel
M
M
Kenet
G
G
Sharon
N
N
Rechavi
G
G
Biniaminov
M
M
Rubanov
V
V
Rosenthal
E
E
Rosner
E
E
Mark
Z
Z
Amariglio
N
N
Brok-Simoni
F
F
D016543:Central Nervous System Neoplasms / Q000175:diagnosis / Q000473:pathology*; D002675:Child, Preschool; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis / Q000473:pathology*; D008297:Male
D017730:Ki-1 Antigen