Acute generalized exanthematous pustulosis induced by paracetamol. A case with severe hemodynamic disturbances.
We report on a 28-year-old Bangladesh man with acute generalized exanthematous pustulosis, induced by paracetamol. The patient presented with an erythematous and pustular eruption after taking 1 tablet of paracetamol for a sore throat. After intravenous administration of propacetamol hydrochloride (which is a prodrug of paracetamol), the rash became worse, showing a toxic epidermal necrolysis-like appearance and the patient suffered from severe hemodynamic disturbances. After discontinuation of propacetamol hydrochloride, the eruption cleared within 2 days. Prick testing performed in the patient revealed a positive reaction for propacetamol hydrochloride.
De Coninck
A L
AL
Department of Dermatology, Academic Hospital, Vrije Universiteit Brussel, Belgium.
Van Strubarq
A S
AS
Pipeleers-Marichal
M A
MA
Huyghens
L P
LP
Suys
E T
ET
Roseeuw
D I
DI
D000082:Acetaminophen / Q000009:adverse effects* / Q000627:therapeutic use; D000208:Acute Disease; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D010328:Patch Tests; D017444:Skin Diseases, Papulosquamous / Q000139:chemically induced*
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen