On the protection by ketorolac of reperfusion-induced heart damage.
This study shows that the nonsteroidal antiinflammatory drug, ketorolac, protects against myocardial damage induced by reperfusion. This effect was analyzed after 5 min of coronary occlusion in rat hearts. The results indicate that ketorolac, at a dose of 1 mg/kg, effectively protects the heart against reperfusion arrhythmias. Furthermore, it protects from the release of lactate dehydrogenase and creatine kinase to the plasma. We propose that the protective effect of the drug might be due to its chelating action on calcium ions, thus preventing the overload of such cation in myocardial cells.
Chávez
E
E
Departamento De Bioquímica, Instituto Nacional De Cardiología, Ignacio Chávez, Tlalpam, México.
Téllez
F
F
Pichardo
J
J
Milán
R
R
Cuéllar
A
A
Carbajal
K
K
Cruz
D
D
D000704:Analysis of Variance; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000517:prevention & control; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D003402:Creatine Kinase / Q000097:blood; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004562:Electrocardiography / Q000187:drug effects; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D020910:Ketorolac; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009206:Myocardium / Q000166:cytology / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014046:Tolmetin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
D016861:Cyclooxygenase Inhibitors; D016166:Free Radical Scavengers; D014046:Tolmetin; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D002118:Calcium; D020910:Ketorolac