title: Mapping of the metalloproteinase gene matrilysin (MMP7) to human chromosome 11q21-->q22.
abstract: The matrix metalloproteinase, matrilysin, is thought to play an important role in the early steps of tumor progression. We determined the chromosome location of the matrilysin gene (MMP7) by Southern and PCR analysis of two different panels of somatic cell hybrids and in situ hybridization of metaphase chromosomes. Matrilysin maps to the region, 11q21-->q22, adding MMP7 to the cluster of matrix metalloproteinase genes that have already mapped to this region.
authors.affiliation: Department of Pathology, University of Arizona, Tucson, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Knox
authors.forename: D R
authors.initials: DR
authors.lastname: Boreham
authors.forename: J A
authors.initials: JA
authors.lastname: Walker
authors.forename: D P
authors.initials: DP
authors.lastname: Morrison
authors.forename: L M
authors.initials: LM
authors.lastname: Matrisian
authors.forename: R B
authors.initials: RB
authors.lastname: Nagle
authors.forename: G T
authors.initials: GT
authors.lastname: Bowden
mesh_terms: D001483:Base Sequence; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D006801:Humans; D020783:Matrix Metalloproteinase 7; D008666:Metalloendopeptidases / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction
chemical_list: D008666:Metalloendopeptidases; D020783:Matrix Metalloproteinase 7