title: Age-related metabolic effects of acetaldehyde on rats with reference to detoxification enzymes and sulfhydryl groups.
abstract: Induced-acetaldehyde toxic effects on gluatathione [GSH] metabolism and sulfhydryl (SH) groups in liver and in brain of female albino rats with reference to age was studied. The total -SH groups were decreased whereas the specific activities of glutathione-S-transferase [GST] and glutathione peroxidase [GPo] were increased in acetaldehyde treated rats. However, the specific activity levels of glutathione reductase [GR] and gamma-glutamylcysteine synthetase [gamma-GCS] were decreased. In general, acetaldehyde induced changes in the specific activities of the enzymes that increase with increasing age.
authors.affiliation: Department of Zoology, S. V. University, Tirupati, India.
authors.forename: G U
authors.initials: GU
authors.lastname: Devi
authors.forename: K
authors.initials: K
authors.lastname: Indira
authors.forename: G R
authors.initials: GR
authors.lastname: Babu
authors.forename: C S
authors.initials: CS
authors.lastname: Chetty
mesh_terms: D000079:Acetaldehyde / Q000633:toxicity*; D000375:Aging / Q000378:metabolism*; D000818:Animals; D005260:Female; D005721:Glutamate-Cysteine Ligase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D008658:Inactivation, Metabolic; D051381:Rats; D017208:Rats, Wistar; D013438:Sulfhydryl Compounds / Q000378:metabolism*
chemical_list: D013438:Sulfhydryl Compounds; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005721:Glutamate-Cysteine Ligase; D005978:Glutathione; D000079:Acetaldehyde