title: Synthesis and pharmacological activity of some N,N-disubstituted 1-amino-2-phenyl-3H,12H-naphtho[1,2-b]pyrano[2,3-d]pyran-3-ones.
abstract: The synthesis of some N,N-disubstituted 1-amino-2-phenyl-3H,12H-naphtho[1,2-b]pyrano[2,3-d]pyran-3-ones 4, by reaction of phenylchloroketene with a series of N,N-disubstituted 3-aminomethylene-2,3-dihydro-4H-naphtho[1,2-b]pyran-4-ones, followed by dehydrochlorination in situ of the primary adducts with DBN, is described. Some compounds 4 showed antiarrhythmic and analgesic activities.
authors.affiliation: Istituto di Scienze Farmaceutiche dell' Università, Genova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Longobardi
authors.forename: A
authors.initials: A
authors.lastname: Bargagna
authors.forename: E
authors.initials: E
authors.lastname: Mariani
authors.forename: W
authors.initials: W
authors.lastname: Filippelli
authors.forename: G
authors.initials: G
authors.lastname: Falcone
authors.forename: I
authors.initials: I
authors.lastname: Marabese
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D009284:Naphthols / Q000737:chemistry / Q000494:pharmacology*; D010147:Pain Measurement
chemical_list: D000889:Anti-Arrhythmia Agents; D009284:Naphthols