The feasibility of HLA matching for lung transplantation.
The benefits of HLA matching have been clearly demonstrated in renal and cardiac transplantation. Recent studies suggest that HLA matching may be associated with improved survival rates for transplantation as well. However, the effect of HLA matching for lung transplantation has not been clearly demonstrated. Despite the possible benefits of HLA compatibility, matching for lung transplantation is based solely on ABO compatibility and lung size. Several factors limit the feasibility of utilizing HLA matching for lung transplantation. Among these factors is the time required to perform HLA typing, to identify appropriate recipients, and to allocate lungs; an additional constraint is the urgent need for transplantation in patients experiencing rapid clinical decline. The obstacles to using prospective HLA matching for lung allocation are significant, and matching lung donors and recipients according to histocompatibility status would require considerable effort. However, with supra-regional cooperation among transplant centers and procurement agencies, it appears feasible to consider HLA matching for lung transplantation. Given the potential for improved survival, a project should be undertaken to determine the impact of HLA matching on the outcome of lung transplantation.
McGee
C
C
Vanderbilt Transplant Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232-4751, USA.
Fox
M D
MD
Loyd
J E
JE
D000017:ABO Blood-Group System / Q000276:immunology; D005240:Feasibility Studies; D006085:Graft Survival; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D016027:Heart Transplantation / Q000276:immunology; D006648:Histocompatibility; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology; D008168:Lung / Q000473:pathology; D016040:Lung Transplantation / Q000276:immunology*; D011446:Prospective Studies; D015996:Survival Rate; D009927:Tissue and Organ Procurement / Q000458:organization & administration; D016896:Treatment Outcome
D000017:ABO Blood-Group System; D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens