title: [Isolated congenital growth hormone deficiency. Severe hypoglycemia and neonatal giant cell hepatitis].
abstract: A case of congenital isolated growth hormone deficiency with neonatal giant cell hepatitis is described. Hypoplasia of the pituitary gland was detected by a MR-scan. Values of IGF-I, IGF-II, and IGF-BP-3 were low. Birth length and weight were normal; hypoglycaemia, jaundice, and failure to thrive were the most pronounced symptoms and present from the first day. Substitution therapy with growth hormone induced a remission of all symptoms. Growth was normal at follow-up at the age of two and a half years.
authors.affiliation: Paediatrisk afdeling, Arhus Kommunehospital.
authors.forename: B H
authors.initials: BH
authors.lastname: Esberg
authors.forename: B B
authors.initials: BB
authors.lastname: Jacobsen
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D015726:Giant Cells / Q000473:pathology*; D013006:Growth Hormone / Q000008:administration & dosage / Q000172:deficiency*; D006505:Hepatitis / Q000151:congenital* / Q000473:pathology; D006801:Humans; D007003:Hypoglycemia / Q000151:congenital* / Q000175:diagnosis; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging
chemical_list: D013006:Growth Hormone