[The phospholipid composition of the heart in rats with acute vasopressin-modelled myocardial ischemia].
The phospholipid composition of the heart of intact and experimental animals has been studied under conditions of simulated acute myocardium ischemia. It is shown that already at the 10th min the phospholipid composition of the heart ventricles changes expressively. The absolute amount of phosphatidylcholine, phosphatidylserine, diphosphatidylglycerol and phosphatidylglycerol decreases reliably. In this case lysophosphatidylethanolamine which is absent in control rats is identified. The amount of other phospholipids does not vary. Simultaneously the percentage of individual phospholipids varies: the phosphatidylethanolamine level significantly increases against the decrease of phosphatidylcholine and phosphatidylserine. As a result of the study of the amount of acylic and plasmalogenic forms of phospholipids it has been found that the level of the diacylic form of phosphatidylcholine in experimental animals falls. The data obtained testify to a definite participation of phospholipids in the pathogenesis of the acute myocardium ischemia.
Horid'ko
T M
TM
Marhitych
V M
VM
Klimashevs'kyĭ
V M
VM
Hovseieva
N M
NM
Puhach
B V
BV
Hula
N M
NM
Frol'kis
V V
VV
D000208:Acute Disease; D000818:Animals; D002855:Chromatography, Thin Layer; D004195:Disease Models, Animal; D008297:Male; D017202:Myocardial Ischemia / Q000139:chemically induced / Q000378:metabolism*; D009206:Myocardium / Q000737:chemistry*; D010743:Phospholipids / Q000032:analysis*; D051381:Rats; D014662:Vasoconstrictor Agents; D014667:Vasopressins
D010743:Phospholipids; D014662:Vasoconstrictor Agents; D014667:Vasopressins