Antithrombin-III activity in plasma of healthy and sick cattle.
Antithrombin-III (AT-III) activity was determined in the plasma of 32 healthy cows. The range of activities was between 105 and 160 per cent of a human reference plasma; the median activity was 132.5 per cent, and the 5 per cent and the 95 per cent quartiles were 111.1 per cent and 153.9 per cent of the standard. The activity of AT-III was also determined in 82 cows with a variety of internal diseases. In cows with hepatopathy, acute enteritis, generalised peritonitis, blood loss, idiopathic cardiomyopathy, glomerulonephritis and disseminated coagulopathy, the activity of AT-III was lower than in healthy animals. The lower values were due to decreased synthesis, increased consumption, or the loss of AT-III. An acquired deficiency of AT-III appears to favour the development of thrombophlebitis.
Pusterla
N
N
Department of Internal Veterinary Medicine, School of Veterinary Medicine, University of Zürich, Switzerland.
Braun
U
U
Forrer
R
R
Lutz
H
H
D000818:Animals; D000990:Antithrombin III / Q000378:metabolism*; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood*; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D012015:Reference Standards
D000990:Antithrombin III