title: Effect of arteether alpha/beta on uncomplicated falciparum malaria cases in Upper Assam.
abstract: Thirty patients of uncomplicated Plasmodium falciparum malaria completed a clinical trial of arteether alpha/beta conducted in a malaria endemic tea garden of district Dibrugarh, Assam. Arteether was given intramuscularly in once a day dose of 150 mg for three consecutive days. The cure rate was 100 per cent with mean fever and parasite clearance time of 42.4 +/- 17.5 and 37.6 +/- 13.6 h respectively. Recrudescence/reinfection rate was 6.7 per cent. Palpable spleens of twenty out of twenty one cases on day 0 became non palpable within 28 days. Following the treatment, percentage of hemoglobin improved marginally with no remarkable change in total and differential leucocyte count. Arteether alpha/beta, besides being a potent and fast acting schizontocidal drug, also exhibited gametocytocidal action on P. falciparum.
authors.affiliation: Regional Medical Research Centre, N.E. Region (ICMR), Dibrugarh.
authors.forename: P K
authors.initials: PK
authors.lastname: Mohapatra
authors.forename: A M
authors.initials: AM
authors.lastname: Khan
authors.forename: A
authors.initials: A
authors.lastname: Prakash
authors.forename: J
authors.initials: J
authors.lastname: Mahanta
authors.forename: V K
authors.initials: VK
authors.lastname: Srivastava
mesh_terms: D000293:Adolescent; D000328:Adult; D000962:Antimalarials / Q000627:therapeutic use*; D037621:Artemisinins; D005260:Female; D006801:Humans; D007194:India; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012717:Sesquiterpenes / Q000627:therapeutic use*
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C055141:artemotil