Stereoconfiguration of anteiso-fatty biosynthesized from DL-isoleucine in rat skin.
Isoleucine (Ile) is a precursor for the biosynthesis of anteiso-fatty acids in rat skin, and among the four possible stereoisomers of Ile, L-Ile, and L-allo-Ile were selectively used for biosynthesis of anteiso-fatty acids. This study examined the optical rotation of anteiso-fatty acid derived from DL-Ile to ascertain its stereoconfiguration. Specific rotation of anteiso-fatty acid derived from DL-Ile favorably compared with that derived from L-Ile, suggesting the selective biosynthesis of the (S)-enantiomer of anteiso-fatty acid in rat skin.
Oku
H
H
Laboratory of Applied Biochemistry, Faculty of Agriculture, University of Ryukyus, Okinawa, Japan.
Sakihama
T
T
Chinen
I
I
D000818:Animals; D005227:Fatty Acids / Q000096:biosynthesis* / Q000737:chemistry; D007532:Isoleucine / Q000378:metabolism*; D008297:Male; D009904:Optical Rotation; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000378:metabolism*; D013237:Stereoisomerism
D005227:Fatty Acids; D007532:Isoleucine