title: [Nodular regenerative hyperplasia associated with primary antiphospholipid syndrome].
abstract: Nodular regenerative hyperplasia of the liver is characterized by diffuse nodularity of the hepatic parenchyma without fibrotic septa. It may be related to venous or arterial obstruction in the portal tract. We report a case of primary antiphospholipid syndrome associated with nodular regenerative hyperplasia in a 45-year old woman. The patient had an ischemic stroke, associated with an acute arterial ischemia of the left leg. She had high titers of serum anticardiolipin antibodies. Nodular regenerative hyperplasia of the liver was histologically confirmed and was associated with anicteric cholestasis. This case provides additional evidence that a thrombotic mechanism may play a role in the pathogenesis of nodular regenerative hyperplasia of the liver.
authors.affiliation: Unité d'Hépatologie, Centre hospitalier Laennec, Creil.
authors.forename: J F
authors.initials: JF
authors.lastname: Cadranel
authors.forename: R
authors.initials: R
authors.lastname: Demontis
authors.forename: C
authors.initials: C
authors.lastname: Guettier
authors.forename: D
authors.initials: D
authors.lastname: Bouraya
authors.forename: M
authors.initials: M
authors.lastname: Dautreaux
authors.forename: A
authors.initials: A
authors.lastname: Ghazali
authors.forename: J M
authors.initials: JM
authors.lastname: Poux
authors.forename: P
authors.initials: P
authors.lastname: Coutarel
authors.forename: B
authors.initials: B
authors.lastname: Devergie
authors.forename: P
authors.initials: P
authors.lastname: Fievet
mesh_terms: D016736:Antiphospholipid Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008099:Liver / Q000473:pathology*; D008875:Middle Aged; D011169:Portal Vein; D013927:Thrombosis / Q000150:complications