[The effect of myelopid on the ultrastructural changes in the rat myocardium induced by an endotoxin].
Ultrastructural changes in the myocardial atria and ventricles have been studied in experiments on rats in the intermediate period of the endotoxin shock, on the stage of late endotoxemia and its correction with myelopid. It was established that 5 hours after endotoxin injection contractile disturbances and intracellular myocytolysis take place and growth of secretory activity is observed in atrial cardiomyocytes. Simultaneously vascular permeability increases. Only the endocrine heart function is restored 3 days later, while dystrophic changes and glycogen depletion are maintained. The myelopid administration beginning from the intermediate period of the endotoxin shock and then once during 3 days, removes most of ultrastructural damages or attenuates their expression.
Kharlanova
N G
NG
Lomov
Iu M
IuM
Bardakhch'ian
E A
EA
D028341:Activins; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D004731:Endotoxins / Q000633:toxicity*; D004926:Escherichia coli; D006321:Heart / Q000187:drug effects*; D008854:Microscopy, Electron; D009206:Myocardium / Q000648:ultrastructure*; D009842:Oligopeptides; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D012772:Shock, Septic / Q000139:chemically induced / Q000473:pathology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D004731:Endotoxins; D009842:Oligopeptides; D010455:Peptides; C044147:activin B; D028341:Activins; C048617:myelopeptides