title: Lack of efficacy of intra-articular opioids for analgesia after day-case arthroscopy.
abstract: A randomised double-blind placebo-controlled trial was undertaken to assess the analgesic efficacy of intra-articular opioids following arthroscopy of the knee. At the completion of surgery, patients received an intra-articular injection of: morphine 1 mg, buprenorphine 30 micrograms or 0.9% saline. There were no differences in pain scores among groups for the first 24 h postoperatively. We have found no clinical evidence for a peripherally-mediated opioid analgesic effect.
authors.affiliation: University Department of Anaesthesia, Queen's Medical Centre, Nottingham.
authors.forename: I J
authors.initials: IJ
authors.lastname: Wrench
authors.forename: P
authors.initials: P
authors.lastname: Taylor
authors.forename: G J
authors.initials: GJ
authors.lastname: Hobbs
mesh_terms: D000328:Adult; D000556:Ambulatory Surgical Procedures; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000627:therapeutic use; D001182:Arthroscopy; D002047:Buprenorphine / Q000008:administration & dosage / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000601:surgery*; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000627:therapeutic use; D010149:Postoperative Pain / Q000517:prevention & control*
chemical_list: D000701:Analgesics, Opioid; D002047:Buprenorphine; D009020:Morphine