[The effect of nerve growth factor on regeneration of the fibers in the rat sciatic nerve].
Exogenic nerve growth factor in the crushed nerve of rat promotes the development of reparative-regenerative processes. This was established by electron microscopy and electrophysiological method and is expressed through the activation of phagocytosis in the remained crushed axons in distal segments, relatively more early and vast penetration of the growing fibres to the outside of the traumatic zone, a single supramaximum stimulation of proximal region above the appearance and growth of action potential amplitude and also its spreading to the periphery as compared to control animals, treated with equal amounts of isotonic natrium chloride.
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D000818:Animals; D008297:Male; D008854:Microscopy, Electron; D009412:Nerve Fibers / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D009414:Nerve Growth Factors / Q000494:pharmacology*; D009416:Nerve Regeneration / Q000187:drug effects*; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D013997:Time Factors
D009414:Nerve Growth Factors