A Mycobacterium tuberculosis IS6110 preferential locus (ipl) for insertion into the genome.
A 267-nucleotide Mycobacterium tuberculosis genomic sequence (ipl, the IS6110 preferential locus) which can harbor the insertion sequence IS6110 at six alternative locations has been identified in some three-quarters of the isolates tested. Only one IS6110 copy was observed at this locus in the ipl::IS6110(+)-containing isolates tested, and all insertions had the same orientation. The implications of this finding for IS6110 fingerprint typing methods is discussed in this work.
Fang
Z
Z
Medical Microbiology, Aberdeen University, Foresterhill, Aberdeen, United Kingdom.
Forbes
K J
KJ
D001483:Base Sequence; D016172:DNA Fingerprinting; D017931:DNA Primers; D004251:DNA Transposable Elements; D016680:Genome, Bacterial; D006801:Humans; D008969:Molecular Sequence Data; D009169:Mycobacterium tuberculosis / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
D017931:DNA Primers; D004251:DNA Transposable Elements