title: [Synthesis and study of immobilized insulin].
abstract: Conjugates of insulin with duck egg-white ovomucoid and soybean trypsin inhibitor were synthesized. The conjugates are highly stable to alpha-chymotrypsin treatment. Oral administration of insulin-ovomucoid conjugates in rabbits significantly lowered blood glucose level unlike administration of insulin-soybean trypsin conjugate.
authors.forename: I L
authors.initials: IL
authors.lastname: Valuev
authors.forename: L I
authors.initials: LI
authors.lastname: Valuev
authors.forename: G A
authors.initials: GA
authors.lastname: Sytov
authors.forename: N A
authors.initials: NA
authors.lastname: Platé
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004372:Ducks; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D007328:Insulin / Q000138:chemical synthesis* / Q000494:pharmacology; D009961:Orosomucoid / Q000494:pharmacology*; D011817:Rabbits; D014360:Trypsin Inhibitor, Kunitz Soybean / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D004791:Enzyme Inhibitors; D007328:Insulin; D009961:Orosomucoid; D014360:Trypsin Inhibitor, Kunitz Soybean