Genetic control of resistance to trypanosomiasis.
To map the genetic sources of trypanotolerance in mice, a linkage analysis of survival following trypanosome challenge was performed by selective genotyping in a large F2 population produced by crossing the resistant C57BL/6 and susceptible BALB/c inbred mouse lines. We report evidence of a chromosomal region of large effect, possibly comprising more than one resistance locus, on Chromosome 17; and of further loci on Chromosomes 1 and 5. Together, these genes can account for all of the difference between the mean parental phenotypes.
Kemp
S J
SJ
International Livestock Research Institute, Nairobi, Kenya.
Darvasi
A
A
Soller
M
M
Teale
A J
AJ
D000818:Animals; D002460:Cell Line; D002874:Chromosome Mapping; D008040:Genetic Linkage / Q000235:genetics; D007113:Immunity, Innate / Q000235:genetics / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013045:Species Specificity; D014352:Trypanosomiasis / Q000235:genetics* / Q000276:immunology* / Q000401:mortality