Hepatitis C virus-related fibrosing cholestatic hepatitis after renal transplantation.
Fibrosing cholestatic hepatitis is a well-described syndrome in patients with immunodeficiency and chronic hepatitis B. It is clinically, biologically, and histologically characterized by rapidly progressive hepatic failure, a mildly elevated serum aminotransferase level, an extensive periportal fibrosis associated with intense cholestasis, mild inflammatory cellular infiltrate, no cirrhosis, and a high hepatocellular level expression of B viral antigens. This syndrome reflected a direct hepatocytopathic injury linked to high intrahepatic viral antigen expression. Because the syndrome of fibrosing cholestatic hepatitis has not been described in chronic hepatitis C, we report the first well-characterized case in a renal transplant patient with chronic hepatitis C and discuss the clinical and pathogenic implications of such a syndrome in this setting.
Zylberberg
H
H
Unité d'Hépatologie et Service de Transplantation Rénale, Hôpital Necker, Paris, France.
Carnot
F
F
Mamzer
M F
MF
Blancho
G
G
Legendre
C
C
Pol
S
S
D000328:Adult; D002779:Cholestasis / Q000209:etiology*; D002908:Chronic Disease; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008103:Liver Cirrhosis / Q000209:etiology*; D017093:Liver Failure / Q000209:etiology*; D008297:Male