[Inactivity of imipramine in the forced swimming test on old mice or on young mice undergone chronic glycinergic treatment].
Balb-C old (10 or 12 months) mice were submitted to the forced swimming test (FST) after treatment by imipramine (IMI) or by glycinergic A agonists (which operate on the strychnine sensitive receptors). The latter, but not IMI, exhibited an anti-immobility effect, predicting an antidepressive activity, in the FST. The same results were obtained with young mice (4 months) having undergone, 48 hours before the administration of IMI or N-linoleyl glycine (glycinergic A) or D-cycloserine (glycinergic B), a chronic (7 days) glycinergic A or B (acting on the strychnine insensitive receptors) treatment. These results could confirm the recent theories on the anti-NMDA effects of acutely or chronically administered IMI and could raise some interesting questions about the possible antidepressive activity of glycinergic A agonists.
Vamvakides
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A
Laboratoire de pharmacologie expérimentale, Faculté de Médecine d'Athènes Goudi, Grèce.
D000367:Age Factors; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D000963:Antimetabolites / Q000008:administration & dosage / Q000494:pharmacology*; D003523:Cycloserine / Q000008:administration & dosage / Q000494:pharmacology*; D018684:Glycine Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007099:Imipramine / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D005082:Physical Exertion; D013550:Swimming
D000929:Antidepressive Agents, Tricyclic; D000963:Antimetabolites; D018684:Glycine Agents; D003523:Cycloserine; D007099:Imipramine