Precocious puberty in two children with neurofibromatosis type I in the absence of optic chiasmal glioma.
A girl aged 5 years and a boy aged 8 years with neurofibromatosis type I had clinical and biochemical evidence of central precocious puberty. Magnetic resonance imaging on two occasions in each patient failed to demonstrate any abnormality of the optic tracts or optic chiasm.
Zacharin
M
M
Department of Endocrinology, Royal Children's Hospital, Melbourne, Victoria, Australia.
D002648:Child; D002675:Child, Preschool; D003390:Cranial Nerve Neoplasms / Q000175:diagnosis; D005260:Female; D005910:Glioma / Q000175:diagnosis; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008525:Medroxyprogesterone / Q000627:therapeutic use; D009456:Neurofibromatosis 1 / Q000150:complications*; D009897:Optic Chiasm / Q000473:pathology; D011629:Puberty, Precocious / Q000188:drug therapy / Q000209:etiology*
D008525:Medroxyprogesterone