title: Gallopamil reduces the post-transplantation acute tubular necrosis in kidneys from aged donors.
abstract: Due to a shortage of suitable kidneys for transplantation there has been an increase in the use of kidneys taken from old and marginal donors, which has led to a high incidence of acute tubular necrosis. Several reports suggest that the administration of calcium channel blockers improves the initial function after renal transplantation. We conducted a randomized, double-blind placebo-controlled trial to study the effect of the calcium channel blocker gallopamil on the incidence and course of acute tubular necrosis following cadaveric renal transplantation. A trend developed showing a decrease in episodes of acute tubular necrosis in gallopamil versus placebo, and became statistically significant when the outcome of kidneys from donors older than 50 years was analyzed separately [gallopamil 6/14 (42%) vs. placebo 10/11 (91%), P <0.01 corrected chi2]. We conclude that pre-transplantation renal graft perfusion and post-transplantation recipient treatment with gallopamil reduces the incidence of post-transplantation acute tubular necrosis, particularly in kidney taken from older donors.
authors.affiliation: Department of Transplantation and Nephrology, Rabin Medical Center, Petah Tikva, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Lustig
authors.forename: D
authors.initials: D
authors.lastname: Shmueli
authors.forename: G
authors.initials: G
authors.lastname: Boner
authors.forename: N
authors.initials: N
authors.lastname: Bar-Nathan
authors.forename: R
authors.initials: R
authors.lastname: Nakache
authors.forename: A
authors.initials: A
authors.lastname: Yussim
authors.forename: E
authors.initials: E
authors.lastname: Shahrabani
authors.forename: Z
authors.initials: Z
authors.lastname: Shapira
mesh_terms: D000328:Adult; D000368:Aged; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004311:Double-Blind Method; D005711:Gallopamil / Q000627:therapeutic use*; D006085:Graft Survival; D006801:Humans; D015994:Incidence; D016030:Kidney Transplantation / Q000009:adverse effects*; D007683:Kidney Tubular Necrosis, Acute / Q000188:drug therapy* / Q000209:etiology; D008875:Middle Aged; D016019:Survival Analysis; D014019:Tissue Donors; D016896:Treatment Outcome
chemical_list: D002121:Calcium Channel Blockers; D005711:Gallopamil