title: In vitro activity of sparfloxacin against Salmonella typhi.
abstract: Comparative in vitro activity of sparfloxacin was determined by the broth dilution method against 104 clinical isolates of Salmonella typhi. All of the isolates were inhibited by < or = 0.12 mg/l of this fluoroquinolone. Its inhibitory activity was slightly superior or comparable to that of other fluoroquinolones tested, namely ciprofloxain and norfloxain, and significantly greater than the conventional drugs, such as amikacin, ampicillin, Augmentin, ceftazidime, clindamycin, tetracycline and trimethoprim-sulfamethoxazole, used in the treatment of typhoid fever.
authors.affiliation: King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
authors.forename: S M
authors.initials: SM
authors.lastname: Qadri
authors.forename: Y
authors.initials: Y
authors.lastname: Ueno
authors.forename: E
authors.initials: E
authors.lastname: Almodovar
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000494:pharmacology*; D012485:Salmonella typhi / Q000187:drug effects*; D012529:Saudi Arabia
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C061363:sparfloxacin