title: Syringin 4-O-beta-glucoside, a new phenylpropanoid glycoside, and costunolide, a nitric oxide synthase inhibitor, from the stem bark of Magnolia sieboldii.
abstract: Syringin 4-O-beta-glucoside (1), a new phenylpropanoid glycoside, and costunolide (2) were isolated from the stem bark of Magnolia sieboldii. The structures were determined by spectroscopic and chemical methods. Costunolide (2) exhibited strong nitric oxide synthase inhibitory activity in the endotoxin-activated murine macrophage, J774.1.
authors.affiliation: Department of Botanical Resources, Sangji University, Wonju, Korea.
authors.forename: H J
authors.initials: HJ
authors.lastname: Park
authors.forename: W T
authors.initials: WT
authors.lastname: Jung
authors.forename: P
authors.initials: P
authors.lastname: Basnet
authors.forename: S
authors.initials: S
authors.lastname: Kadota
authors.forename: T
authors.initials: T
authors.lastname: Namba
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004396:Coloring Agents; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D006868:Hydrolysis; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007785:Lactose / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D019441:Plant Epidermis / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet; D013778:Tetrazolium Salts; D013844:Thiazoles; D007783:Lactones
chemical_list: D004396:Coloring Agents; D004791:Enzyme Inhibitors; D007166:Immunosuppressive Agents; D007785:Lactose; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D012717:Sesquiterpenes; D013778:Tetrazolium Salts; D013844:Thiazoles; C103979:syringin 4-O-beta-glucoside; C002602:costunolide; D007783:Lactones; C022616:thiazolyl blue