Peripheral blood mobilization of hematopoietic stem cells: cytokine-mediated regulation of adhesive interactions within the hematopoietic microenvironment.
Peripheral blood (PB) mobilization of hematopoietic progenitors, presently regarded as an alternative source of cells intended for autologous or allogeneic bone marrow (BM) transplantation, supports a role for cytokines in the regulated adhesion of hematopoietic compartments to the BM microenvironment. Two major consequences might result from cytokine-induced rearrangements of adhesive interactions within the hematopoietic tissue, both potentially relevant for clinical purposes of PB grafts. The first one, arising from abrogated adhesion of hematopoietic stem cells to their microenvironmental 'niche', which is critical for the maintenance of cell cycle quiescence and endurability, might result in some impairment of the long-term repopulating potential of PB grafts. The second and possibly more harmful one is due to the inability of the cytokine to distinguish between normal and transformed cells, and would likely result in graft contamination by tumor cells, increasing the metastasizing potential of hematological malignancies and solid tumors.
Santucci
M A
MA
Istituto di Cancerologia, Università di Bologna, Italia.
Lemoli
R M
RM
Tura
S
S
D001773:Blood Cells / Q000166:cytology* / Q000187:drug effects; D001853:Bone Marrow / Q000098:blood supply / Q000187:drug effects; D001854:Bone Marrow Cells; D002448:Cell Adhesion; D002465:Cell Movement; D019337:Hematologic Neoplasms / Q000473:pathology / Q000628:therapy; D016298:Hematopoietic Cell Growth Factors / Q000009:adverse effects / Q000502:physiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000473:pathology; D009360:Neoplastic Cells, Circulating; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000473:pathology
D016298:Hematopoietic Cell Growth Factors