Gastrointestinal actions of buprenorphine: are different receptors involved?
The effects of buprenorphine on castor-oil-induced diarrhoea, gastrointestinal transit and ethanol-induced gastric lesions in rats were compared to the same effects of morphine. Like morphine, buprenorphine prevented castor-oil-induced diarrhoea. However, it has no effect on gastrointestinal transit per se but prevented the inhibitory action of morphine. While morphine protected against ethanol-induced gastric lesions, buprenorphine aggravated them. It is suggested that different types/subtypes of opioid receptors may be involved in the gastrointestinal actions of buprenorphine.
Bhounsule
S A
SA
Department of Pharmacology, Goa Medical College, India.
D'Sa
S
S
Fernandes
N
N
D'Souza
R D
RD
Dhume
V G
VG
D000818:Animals; D002047:Buprenorphine / Q000494:pharmacology*; D003967:Diarrhea / Q000188:drug therapy*; D004064:Digestive System / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D009270:Naloxone; D002047:Buprenorphine; D009020:Morphine