title: Prevention of hypotension during spinal anesthesia: a comparison of intravascular administration of hetastarch versus lactated Ringer's solution.
abstract: This study was designed to compare the efficacy of 6% hetastarch to that of crystalloid administration in reducing the incidence and severity of hypotension during spinal anesthesia. Forty ASA grade I patients scheduled for postpartum tubal ligations under spinal anesthesia were randomly allocated to receive either 500 mL of hetastarch solution or 1000 mL of lactated Ringer's solution prior to spinal anesthesia. Spinal anesthesia was managed identically in both groups by anesthesiologists who were unaware of the type of fluid administered. The incidence of hypotension was 11 of 21 (52%) in the lactated Ringer's solution group and 3 of 19 (16%) in the hetastarch group. The difference in the incidence of hypotension was significant (P < 0.05). The requirement of 5-mg bolus doses of ephedrine to maintain systolic arterial blood pressure > 75% of baseline was significantly greater in the lactated Ringer's group than in the hetastarch group (15 vs 4, P < 0.05). We conclude that an intravenous infusion of 500 mL of 6% hetastarch solution is more effective than 1000 mL lactated Ringer's solution in attenuating spinal anesthesia induced hypotension in women undergoing postpartum tubal ligation.
authors.affiliation: Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical School, Dallas 75235-9068, USA.
authors.forename: S K
authors.initials: SK
authors.lastname: Sharma
authors.forename: N M
authors.initials: NM
authors.lastname: Gajraj
authors.forename: J E
authors.initials: JE
authors.lastname: Sidawi
mesh_terms: D000328:Adult; D000775:Anesthesia, Spinal / Q000009:adverse effects*; D000077324:Crystalloid Solutions; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage*; D007022:Hypotension / Q000209:etiology / Q000517:prevention & control*; D007262:Infusions, Intravenous; D007552:Isotonic Solutions / Q000008:administration & dosage*; D010952:Plasma Substitutes / Q000008:administration & dosage*; D011300:Preoperative Care; D000077325:Ringer's Lactate; D013246:Sterilization, Tubal
chemical_list: D000077324:Crystalloid Solutions; D006895:Hydroxyethyl Starch Derivatives; D007552:Isotonic Solutions; D010952:Plasma Substitutes; D000077325:Ringer's Lactate