Effects of fenthion, isoxathion, dichlorvos and propaphos on the serum cholinesterase isoenzyme patterns of dogs.
The serum cholinesterase (ChE) isoenzyme patterns consist of 5 bands for normal beagle dogs. We examined the ChE isoenzyme patterns and ChE activities of 4 groups, each of which consisted of 4 dogs, given the organophosphate (OP) compounds fenthion (P = S type), isoxathion (P = S type), dichlorvos (P = O type) or propaphos (P = O type) po at 220, 75, 120 or 90 mg/kg respectively. Blood samples were collected for 30 d after the OP administrations. ChE isoenzyme bands 4 and 5 were inhibited 12 h after fenthion and isoxathion administration; dichlorvos and propaphos produced suppression of main bands 4 and 5 20 min after administration. This change was effective to differentiate the type of OP administered (P = S and P = O), while the main ChE isoenzyme bands of dog serum reflected inhibition of serum ChE activity.
Sakaguchi
K
K
Department of Environmental Health, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
Nagayama
M
M
Masaoka
T
T
Nishimura
A
A
Kageyama
K
K
Shirai
M
M
Akahori
F
F
D000818:Animals; D002802:Cholinesterases / Q000097:blood*; D004006:Dichlorvos / Q000633:toxicity*; D004285:Dogs; D004912:Erythrocytes / Q000201:enzymology; D005284:Fenthion / Q000633:toxicity*; D007306:Insecticides / Q000633:toxicity*; D007527:Isoenzymes / Q000097:blood*; D009943:Organophosphorus Compounds / Q000633:toxicity*
D007306:Insecticides; D007527:Isoenzymes; D009943:Organophosphorus Compounds; C019540:propaphos; D004006:Dichlorvos; D005284:Fenthion; D002802:Cholinesterases