Amino acids excess increase SCEs in human lymphocytes.
The effects of 21 amino acids on sister-chromatid exchanges (SCEs) in human lymphocytes were investigated. Addition of each of the 21 amino acids, originally in a composition of the culture medium RPMI 1640, at three different concentrations (10 micrograms/ml, 50 micrograms/ml and 100 micrograms/ml) caused a dose-independent increase in SCE frequency. The results indicated that amino acids, although indispensable for cells in vivo and in vitro, may be SCE-inducing agents.
Xing
W
W
Department of Biology, Inner Mongolia Medical College, Hohhote, China.
Na
R
R
D000596:Amino Acids / Q000494:pharmacology*; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000502:physiology; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D000596:Amino Acids; D003470:Culture Media