T-lymphocyte proliferative response to mitogen stimulation in elderly depressed patients.
T-lymphocyte responses to phytohemoagglutinin (PHA) stimulation were examined in 10 elderly women with nonmelancholic Major Depressive Disorders (MDD), in 10 age- and sex-matched controls and in 10 young female controls, before and after in vivo stimulation with corticotropin-releasing hormone (CRH). The tests were repeated in MDD patients after 30 days of therapy with phosphatidylserine (BC-PS), 200 mg/day, p.o. T-lymphocyte responses to PHA stimulation did not differ in the three groups, and were not changed by CRH administration. BC-PS therapy, while significantly improving the depressive symptomatology, did not modify the T-lymphocyte response to PHA, either before or after CRH stimulation.
Brambilla
F
F
Ospedale Psichiatrico Pini, Milano, Italy.
Maggioni
M
M
Cenacchi
T
T
Sacerdote
P
P
Panerai
A R
AR
D000328:Adult; D000367:Age Factors; D000368:Aged; D001714:Bipolar Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D003346:Corticotropin-Releasing Hormone; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology*; D008875:Middle Aged; D010718:Phosphatidylserines / Q000627:therapeutic use; D010835:Phytohemagglutinins / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D016896:Treatment Outcome
D010718:Phosphatidylserines; D010835:Phytohemagglutinins; D003346:Corticotropin-Releasing Hormone