Effect of antihypertensive therapy in preeclampsia on levels of serum interleukin-4.
We investigated the effects of antihypertensive therapy on serum levels of interleukin-4 using InterTest-4 ELISA in 25 preeclamptic women; 14 were placed on treatment, while 11 were not. Comparison was made with 14 non-preeclamptic pregnant controls. Interleukin-4 levels were significantly lower in the controls than in the treated preeclamptic women (p < 0.001): 68.6 +/- 10.9 versus 106.1 +/- 13.2, 64.7 +/- 9.6 versus 119.8 +/- 11.4, 90.2 +/- 9.1 versus 124.3 +/- 15.7, and 65.6 +/- 3.6 versus 109.7 +/- 11.4 pg/ml, during antepartum, early intrapartum, late intrapartum and postpartum periods, respectively. No significant differences were detected between the therapy and no therapy subgroups (p > 0.05). This shows that antihypertensive therapy has no effect on interleukin-4 levels.
Omu
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Department of Obstetrics, Faculty of Medicine, Kuwait University and Maternity Hospital, Kuwait.
Makhseed
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M
al-Qattan
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F
D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006830:Hydralazine / Q000008:administration & dosage; D007262:Infusions, Intravenous; D015847:Interleukin-4 / Q000097:blood* / Q000502:physiology; D007741:Labetalol / Q000008:administration & dosage*; D008750:Methyldopa / Q000008:administration & dosage*; D011225:Pre-Eclampsia / Q000097:blood* / Q000188:drug therapy; D011247:Pregnancy
D000959:Antihypertensive Agents; D015847:Interleukin-4; D006830:Hydralazine; D008750:Methyldopa; D007741:Labetalol