Hemorheological profile in patients with cardiovascular risk factors.
In order to find out whether hemorheological alterations precede the atherosclerotic lesions and could constitute an atherothrombotic risk factor, we studied the hemorheological profile in 150 healthy normotensive offspring whose parents were diagnosed as having essential hypertension WHO I-II grade and in another group of 40 children with familial hypercholesterolemia (FH) but without vascular atherosclerosis lesions, whose parents also suffer from FH. In offspring of hypertensive individuals, a significant increase in the fibrinogen level with respect to the control group was found both in males and females. In addition, only the female offspring showed a higher leucocyte count. FH children showed increased erythrocyte aggregation and increased plasma viscosity with respect to the control group. The fact that the rheological alterations appear prior to the development of the vascular lesion suggests that they could play a role in the pathogenesis of the atherosclerotic process.
Vayá
A
A
Department of Clinical Pathology, La Fe Hospital, Valencia, Spain.
Martínez
M
M
Dalmau
J
J
Labios
M
M
Aznar
J
J
D000293:Adolescent; D000328:Adult; D001809:Blood Viscosity; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D004903:Erythrocyte Aggregation; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D018056:Hemorheology; D006579:Heterozygote; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000235:genetics; D006973:Hypertension / Q000235:genetics; D008297:Male; D012307:Risk Factors; D012737:Sex Factors
D005340:Fibrinogen