[Prostaglandins E concentration in gastric mucosa and synthesis of interleukin-1 (IL-1) in different clinical variants of gastric ulcer].
Measurements of serum IL-1 levels and PGE-2 content in biopsies from gastric mucosa at ulcer margins were made in 30 patients with gastric ulcer running differently. The highest IL-1 production and low PGE-2 levels were typical for healing ulcer. Cicatrization was accompanied with normalization of IL-1 and PGE-2 values. Gastric ulcer with a severe course exhibited inhibited IL-1 synthesis and decreased production of PGE-2.
Mikriukova
V I
VI
Department of Therapy, Siberian Medical Institute, Tomsk.
Beloborodova
E I
EI
D000328:Adult; D001706:Biopsy; D016145:Endoscopy, Digestive System; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D008297:Male; D011458:Prostaglandins E / Q000378:metabolism*; D013276:Stomach Ulcer / Q000378:metabolism* / Q000473:pathology
D007375:Interleukin-1; D011458:Prostaglandins E