The spectrum of chronic mature T-cell disorders: a report of four cases.
We describe four patients with a mature T-cell disorder. These four specific entities belong to a group formerly called "T-cell chronic lymphocytic leukaemia" (T-CLL). Nowadays we understand that these chronic T-cell lymphoproliferative disorders consist of four different entities. They stand out as well-described and separate disorders on the basis of their clinical, immunophenotypic and cytogenetic properties. Unfortunately, the majority of patients have a bad response to chemotherapy. The purine analogs may offer a better prognosis for some patients.
Brouwer
R E
RE
Department of Internal Medicine, Rode Kruis Hospital, Hague, Netherlands.
Kok
S W
SW
van Deijk
W A
WA
Wijermans
P W
PW
D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D006801:Humans; D015458:Leukemia, T-Cell / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D008232:Lymphoproliferative Disorders / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D009182:Mycosis Fungoides / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D011379:Prognosis; D011687:Purines / Q000627:therapeutic use; D012751:Sezary Syndrome
D011687:Purines