Embryonic spinal cord transplants enhance locomotor performance in spinalized newborn rats.
The results of the present experiments demonstrate that fetal spinal cord transplants placed into the site of a complete transection in newborn rats permit the development of complex patterns of locomotion. These patterns differ in some respects from normal, but include weight support, appropriate postural adjustment, and coordination between forelimbs and hindlimbs. 5-HT agonists administered to transplanted rats can further modify these motor patterns in ways that may prove able to enhance locomotion. When placed into lesion cavities in adult spinal cord, cells genetically modified to express neurotrophins can survive, differentiate, and mimic at least one consequence of fetal transplants, rescue of axotomized neurons from retrograde cell death.
Tessler
A
A
Veterans Administration Medical Center, Philadelphia, Pennsylvania, USA.
Fischer
I
I
Giszter
S
S
Himes
B T
BT
Miya
D
D
Mori
F
F
Murray
M
M
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D016332:Fetal Tissue Transplantation / Q000502:physiology*; D008124:Locomotion / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D051381:Rats; D013116:Spinal Cord / Q000637:transplantation*; D013119:Spinal Cord Injuries / Q000628:therapy*