[The diagnosis of microcirculatory-rheological disorders and their correction in patients with the initial manifestations of insufficiency of the cerebral blood supply].
An evaluation was done of the state of bulbar microcirculation and aggregability of blood platelets in 47 patients presenting with early manifestations of cerebral circulatory insufficiency. A correlation was established between the revealed disturbances in the microcirculatory bed and augmentation of aggregational activity of thrombocytes. Computation of the integrative guide, microcirculatory-rheologic index, reflecting objectively the degree of intravascular hemocirculatory disorders has been performed. Treatment with calcium antagonist corinfar, antihypoxic agent actovegin was of particular benefit for the patients when administered in combination; more than half of the parameters characterizing microcirculation, rheologic properties of blood, microcirculatory-rheologic index have all returned to normal.
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D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage; D001809:Blood Viscosity / Q000187:drug effects; D001921:Brain / Q000098:blood supply* / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000008:administration & dosage; D002561:Cerebrovascular Disorders / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D003228:Conjunctiva / Q000098:blood supply; D004359:Drug Therapy, Combination; D006418:Heme / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D008833:Microcirculation / Q000187:drug effects / Q000503:physiopathology; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage; D010974:Platelet Aggregation / Q000187:drug effects
D000975:Antioxidants; D002121:Calcium Channel Blockers; D006418:Heme; C015646:Actovegin; D009543:Nifedipine