Pharmacokinetics of a new nitroderivative of acetylsalicylic acid after a single dose in rats.
The pharmacokinetics of a new ASA-nitroderivative compound, NCX 4016 (ASA-NO2), was evaluated using an HPLC method. After single equimolar doses of ASA (35 mg kg(-1)) or ASA-NO2 (65 mg kg(-1)), no detectable levels of these compounds have been observed in rat plasma samples. SA peak levels were obtained at 3 h and 6 h after ASA and ASA-NO2 administration respectively. The elimination rate constants of SA were similar after ASA and ASA-NO2, suggesting a similar elimination phase of this metabolite in rats. From these data it is evident that ASA-NO2 is slowly metabolized in ASA, which is rapidly converted to SA.
Tagliaro
F
F
Institutes of Pharmacology and Forensic Medicine, University of Verona, Italy.
Cuzzolin
L
L
Adami
A
A
Scarcella
D
D
Crivellente
F
F
Benoni
G
G
D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D051381:Rats; D017207:Rats, Sprague-Dawley
D001241:Aspirin