title: Transforming growth factor-alpha, like epidermal growth factor, stimulates cell proliferation and inhibits prolactin secretion in the human decidual cells in vitro.
abstract: In order to clarify the biological action of transforming growth factor alpha (TGF-alpha) in the human decidua, we investigated the effects of TGF-alpha on cell proliferation and prolactin (PRL) secretion in cultured decidual cells in vitro. TGF-alpha had a stimulatory effect on DNA synthesis in decidual cells and an inhibitory effect on PRL secretion from these cells. These results suggest that TGF-alpha, like epidermal growth factor (EGF), may be one of the substances which regulate decidual function.
authors.affiliation: Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Taga
authors.forename: M
authors.initials: M
authors.lastname: Saji
authors.forename: K
authors.initials: K
authors.lastname: Suyama
authors.forename: H
authors.initials: H
authors.lastname: Minaguchi
mesh_terms: D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D003656:Decidua / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000494:pharmacology; D011247:Pregnancy; D045167:Progesterone Congeners / Q000494:pharmacology; D011388:Prolactin / Q000187:drug effects / Q000378:metabolism*; D013936:Thymidine / Q000032:analysis / Q000378:metabolism; D016211:Transforming Growth Factor alpha / Q000494:pharmacology*; D014316:Tritium
chemical_list: D045167:Progesterone Congeners; D016211:Transforming Growth Factor alpha; D014316:Tritium; D011388:Prolactin; D017258:Medroxyprogesterone Acetate; D013936:Thymidine