title: [Successful electroconvulsive therapy of Cotard syndrome with bitemporal hypoperfusion].
abstract: A case study is presented to illustrate a rare condition described by Cotard as "délire de négation". The central symptom is a nihilistic delusion with denial of one's own existence of oneself and that of the external world. In the present case, the syndrome became manifest as an escalation of a recurrent depressive disorder late in life. After initial resistance to therapy, the syndrome was successfully treated with electroconvulsive therapy. For the first time, we report the regional cerebral blood flow measured by 99mTc-HMPAO-SPECT before and after therapy. Before treatment, significant bitemporal hypoperfusion relative to the cerebellum was found, which was no longer demonstrable on remission.
authors.affiliation: Klinik für Psychiatrie und Psychotherapie, RWTH, Aachen.
authors.forename: T
authors.initials: T
authors.lastname: Lohmann
authors.forename: K
authors.initials: K
authors.lastname: Nishimura
authors.forename: O
authors.initials: O
authors.lastname: Sabri
authors.forename: J
authors.initials: J
authors.lastname: Klosterkötter
mesh_terms: D000368:Aged; D003702:Delusions / Q000000981:diagnostic imaging / Q000523:psychology / Q000628:therapy*; D003717:Denial, Psychological; D003866:Depressive Disorder / Q000000981:diagnostic imaging / Q000523:psychology / Q000628:therapy*; D004292:Dominance, Cerebral / Q000502:physiology; D004565:Electroconvulsive Therapy; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D012039:Regional Blood Flow / Q000502:physiology; D013577:Syndrome; D019690:Technetium Tc 99m Exametazime; D013702:Temporal Lobe / Q000098:blood supply* / Q000000981:diagnostic imaging; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime