title: Novel anti-calcification treatment of biological tissues by grafting of sulphonated poly(ethylene oxide).
abstract: Biological porcine tissue was modified by the direct coupling of sulphonated poly(ethylene oxide) (PEO-SO3) containing amino acid end groups after glutaraldehyde fixation. The calcification of the modified tissue [bioprosthetic tissue (BT)-PEO-SO3] and control (BT control) was investigated by in vivo rate subdermal, canine aorta-illiac shunt and right ventricle-pulmonary artery shunt implantation models. Less calcium deposition of BT-PEO-SP3 than of BT control was observed in in vivo tests. Such a reduced calcification of BT-PEO-SO3 can be explained by decreases of residual glutaraldehyde groups, a space filling effect and, therefore, improved biostability and synergistic blood-compatible effects of PEO and SO3 groups after the covalent binding of PEO-SO3 to tissue. This simple method can be a useful anti-calcification treatment for implantable tissue valves.
authors.affiliation: Polymer Chemistry Laboratory, Korea Institute of Science and Technology, Seoul, Korea.
authors.forename: K D
authors.initials: KD
authors.lastname: Park
authors.forename: W K
authors.initials: WK
authors.lastname: Lee
authors.forename: J Y
authors.initials: JY
authors.lastname: Yun
authors.forename: D K
authors.initials: DK
authors.lastname: Han
authors.forename: S H
authors.initials: SH
authors.lastname: Kim
authors.forename: Y H
authors.initials: YH
authors.lastname: Kim
authors.forename: H M
authors.initials: HM
authors.lastname: Kim
authors.forename: K T
authors.initials: KT
authors.lastname: Kim
mesh_terms: D000818:Animals; D001021:Aortic Valve / Q000378:metabolism*; D001166:Arteriovenous Shunt, Surgical; D001807:Blood Vessel Prosthesis; D002113:Calcification, Physiologic; D002118:Calcium / Q000378:metabolism; D004285:Dogs; D006350:Heart Valve Prosthesis; D008297:Male; D011092:Polyethylene Glycols; D019736:Prostheses and Implants; D051381:Rats; D013451:Sulfonic Acids; D013552:Swine
chemical_list: D013451:Sulfonic Acids; D011092:Polyethylene Glycols; D002118:Calcium