title: Solitary pancreas allografts. The role of percutaneous biopsy and standardized histologic grading of rejection.
abstract: OBJECTIVE
  To determine the potential impact of ultrasound-guided percutaneous pancreas allograft biopsy and standardized histologic grading on graft and patient survival in a solitary pancreas transplant program.
  
  
  METHODS
  Retrospective case series survey.
  
  
  METHODS
  Tertiary care, university teaching hospital.
  
  
  METHODS
  Thirty-five recipients of solitary pancreas transplants.
  
  
  METHODS
  Percutaneous pancreas allograft biopsies were performed in solitary pancreas transplant recipients.
  
  
  METHODS
  Actuarial graft and patient survival, cause of graft loss.
  
  
  RESULTS
  Initiation of ultrasound-guided percutaneous pancreas allograft biopsy with standardized histologic grading is associated with a 70% 1-year graft survival and 93% 1-year patient survival in solitary pancreas transplantation. Acute rejection was responsible for only 11% of cases of graft loss. The presence of endotheliitis, vasculitis, or confluent acinar necrosis is associated with decreased pancreas allograft survival, poor response to corticosteroid therapy, and shortened time interval to ultimate graft loss. Clinical criteria for acute rejection such as elevated serum amylase or lipase levels, 50% decrease in urinary amylase levels, unexplained fever, or hyperglycemia are associated with a positive predictive value of only 72%.
  
  
  CONCLUSIONS
  Pancreas allograft biopsy and standardized histologic grading are associated with significantly improved 1-year graft and patient survival in solitary pancreas transplantation.
authors.affiliation: Department of Surgery, University of Maryland Medical Systems, Baltimore, USA.
authors.forename: P C
authors.initials: PC
authors.lastname: Kuo
authors.forename: L B
authors.initials: LB
authors.lastname: Johnson
authors.forename: E J
authors.initials: EJ
authors.lastname: Schweitzer
authors.forename: D K
authors.initials: DK
authors.lastname: Klassen
authors.forename: E W
authors.initials: EW
authors.lastname: Hoehn-Saric
authors.forename: M R
authors.initials: MR
authors.lastname: Weir
authors.forename: C B
authors.initials: CB
authors.lastname: Drachenberg
authors.forename: J C
authors.initials: JC
authors.lastname: Papadimitriou
authors.forename: S T
authors.initials: ST
authors.lastname: Bartlett
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D001706:Biopsy; D005260:Female; D006084:Graft Rejection / Q000473:pathology*; D006085:Graft Survival; D006801:Humans; D008297:Male; D016035:Pancreas Transplantation / Q000473:pathology*; D011237:Predictive Value of Tests; D012189:Retrospective Studies