title: Tumors in bladder remnant after augmentation enterocystoplasty.
abstract: OBJECTIVE
  We attempted to determine the tissue of origin of tumors after augmentation enterocystoplasty.
  
  
  METHODS
  We retrospectively reviewed the histological findings of 4 tumors that developed after clam ileocystoplasty.
  
  
  RESULTS
  Tumors were primarily adenocarcinoma that originated on the bladder side of the anastomosis. The urothelium showed glandular metaplasia and dysplasia with intestinalization overlying normal detrusor muscle. These changes were also present in the renal pelvis in 1 patient with ureteral reflux. Bowel mucosa was normal except for inflammation.
  
  
  CONCLUSIONS
  These tumors are derived from urothelium, which may be due to elevated urinary nitrosamines in this group of patients.
authors.affiliation: Department of Urology, University Hospital of Wales, Heath Park, Cardiff, South Glamorgan, United Kingdom.
authors.forename: J W
authors.initials: JW
authors.lastname: Barrington
authors.forename: S
authors.initials: S
authors.lastname: Fulford
authors.forename: D
authors.initials: D
authors.lastname: Griffiths
authors.forename: T P
authors.initials: TP
authors.lastname: Stephenson
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology / Q000601:surgery*; D000328:Adult; D015653:Cystectomy; D005260:Female; D006801:Humans; D007082:Ileum / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D001749:Urinary Bladder Neoplasms / Q000209:etiology / Q000473:pathology* / Q000601:surgery*; D014547:Urinary Diversion / Q000009:adverse effects*