Mitosis: don't get mad, get even.
The 'mitotic spindle checkpoint' ensures that, before a cell exits from mitosis, all of its chromosomes are aligned on the spindle to form the metaphase plate. Mad2 is an essential component of this checkpoint system and it binds specifically to unattached kinetochores.
Glotzer
M
M
Cell Biology Program, European Molecular Biology Laboratory, Heidelberg, Germany. michael.glotzer@mailserver.embl-heidelberg.DE
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism*; D008025:Ligases / Q000235:genetics; D008938:Mitosis / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D051899:Smad2 Protein; D008941:Spindle Apparatus / Q000502:physiology; D015534:Trans-Activators; D044763:Ubiquitin-Conjugating Enzymes
D004268:DNA-Binding Proteins; D051899:Smad2 Protein; D015534:Trans-Activators; D044763:Ubiquitin-Conjugating Enzymes; D008025:Ligases