title: Desensitization of bladder sensory fibers by intravesical capsaicin has long lasting clinical and urodynamic effects in patients with hyperactive or hypersensitive bladder dysfunction.
abstract: OBJECTIVE
  Capsaicin was used to treat symptomatic patients with hyperactive or hypersensitive bladders.
  
  
  METHODS
  Capsaicin solution (1 mM.) was instilled into the bladder of 16 patients with spinal hyperreflexia, bladder instability or hypersensibility.
  
  
  RESULTS
  Frequency decreased in 14 patients and continence was achieved in 10 of 14 incontinent cases. Mean first desire to void and maximal cystometric capacity increased significantly. These effects lasted for 6 to 12 months and were renewed following repeat treatment.
  
  
  CONCLUSIONS
  Bladder afferent desensitization with capsaicin is promising in patients with motor or sensory bladder dysfunction, although initial pungency might limit its use.
authors.affiliation: Department of Urology, Hospital S. João, Porto, Portugal.
authors.forename: F
authors.initials: F
authors.lastname: Cruz
authors.forename: M
authors.initials: M
authors.lastname: Guimarães
authors.forename: C
authors.initials: C
authors.lastname: Silva
authors.forename: M E
authors.initials: ME
authors.lastname: Rio
authors.forename: A
authors.initials: A
authors.lastname: Coimbra
authors.forename: M
authors.initials: M
authors.lastname: Reis
mesh_terms: D000283:Administration, Intravesical; D000328:Adult; D000368:Aged; D002211:Capsaicin / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D001743:Urinary Bladder / Q000187:drug effects* / Q000294:innervation*; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy* / Q000503:physiopathology; D014563:Urodynamics / Q000187:drug effects
chemical_list: D002211:Capsaicin