Interspecies scaling: predicting clearance of anticancer drugs in humans. A comparative study of three different approaches using body weight or body surface area.
From this study it is proposed that the clearance of anti-cancer drugs may be best estimated if they follow the following trend: (i) that if the exponent of the allometric equation (clearance vs body weight) lies between 0.55-0.75 (0.75 was chosen after Kleiber's power rule (18)), then a simple allometric equation can predict the clearance reasonably well; (ii) if the exponent of the allometric equation lies between 0.75 to approximately 0.90, clearance can be reasonably predicted using CL x MLP; and (iii) if the exponent of the allometric equation is > or = 0.90, the clearance can be predicted using the product of clearance and brain weight.
Mahmood
I
I
Division of Pharmaceutical Evaluation I, Office of Clinical Pharmacology and Biopharmaceutics, Food and Drug Administration, Rockville, MD 20852, USA.
D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D001830:Body Surface Area; D001835:Body Weight; D006801:Humans; D008433:Mathematics; D008657:Metabolic Clearance Rate; D013045:Species Specificity
D000970:Antineoplastic Agents