The IGHG3 gene shows a structural polymorphism characterized by different hinge lengths: sequence of a new 2-exon hinge gene.
Four of the five human IGHG genes (G1, GP, G2, and G4) display a hinge region consisting of a unique exon. In contrast, IGHG3 exhibits a different structure in which the hinge is constituted by four or, less frequently, three exons. We report here the nucleotide sequence of a new 2-exon hinge G3 gene found in a Mandenka individual from Eastern Senegal. A comparison of this sequence with that of 4-exon and 3-exon hinge G3 genes suggests that the 3-exon and 2-exon hinge forms arose independently by deletion events in a 4-exon hinge gene.
Dard
P
P
Département d'Anthropologie et d'Ecologie, Université de Genève, Switzerland.
Huck
S
S
Frippiat
J P
JP
Lefranc
G
G
Langaney
A
A
Lefranc
M P
MP
Sanchez-Mazas
A
A
D001402:B-Lymphocytes; D001483:Base Sequence; D002460:Cell Line; D017931:DNA Primers; D005006:Ethnicity / Q000235:genetics; D005091:Exons; D005803:Genes, Immunoglobulin; D052058:Hinge Exons; D006720:Homozygote; D006801:Humans; D007074:Immunoglobulin G / Q000235:genetics*; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D015183:Restriction Mapping; D012675:Senegal; D017384:Sequence Deletion
D017931:DNA Primers; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains