Self-induced water intoxication treated with risperidone.
OBJECTIVE
To determine whether or not risperidone is efficacious in treating self-induced water intoxication in patients with chronic schizophrenia.


METHODS
We carried out a prospective 11-month open-label study using risperidone to treat 8 men with chronic schizophrenia and self-induced water intoxication.


RESULTS
The 8 men were not able to reduce their fluid consumption compared with their baseline intake. Risperidone, however, significantly decreased the Brief Psychiatric Rating Scale (BPRS) scores of this very chronic group.


CONCLUSIONS
Although risperidone decreased schizophrenic symptoms, it did not have significant efficacy in treating self-induced water intoxication. This study may have implications for the treatment of addictive behaviour.
Millson
R C
RC
Acute Assessment and Treatment Program, Riverview Hospital, Port Coquitlam, British Columbia.
Emes
C E
CE
Glackman
W G
WG
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002908:Chronic Disease; D004326:Drinking / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D018967:Risperidone / Q000009:adverse effects / Q000627:therapeutic use*; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D016896:Treatment Outcome; D014869:Water Intoxication / Q000188:drug therapy* / Q000523:psychology
D014150:Antipsychotic Agents; D018967:Risperidone