Stereocontrolled syntheses of O-glycans of core class 2 with a linear tetrameric lactosamine chain and with three lactosamine branches.
Synthetic routes to O-glycans of core class 2 with a linearly extended tetralactosamine moiety and with three lactosamine branches are discussed. By a glycosyl fluoride-method, the mono- and the di-lactosaminyl units were attached to the core disaccharide (Gal beta 1-->3GalN3) derivatives in high stereoselectivity.
Wang
Z G
ZG
Institute of Physical and Chemical Research (RIKEN), Saitama, Japan.
Zhang
X F
XF
Ito
Y
Y
Nakahara
Y
Y
Ogawa
T
T
D000606:Amino Sugars / Q000138:chemical synthesis* / Q000378:metabolism; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D004187:Disaccharides / Q000138:chemical synthesis / Q000378:metabolism; D005947:Glucose / Q000031:analogs & derivatives / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D011134:Polysaccharides / Q000138:chemical synthesis*
D000606:Amino Sugars; D004187:Disaccharides; D011134:Polysaccharides; C066929:polylactosamine; C032233:lactosamine; C030364:glucosyl fluoride; D005947:Glucose