[The effect of neural transplantation on audiogenic seizures in rats of different genetic strains].
The effects of neurotransplantation on development of audiogenic seizures (AS) were studied in Krushinskiĭ-Molodkina (KM) rats genetically predisposed to AS and in Wistar rats especially selected for AS. Within 24 weeks after bilateral combined transplantation of the newborn striatum and cerebellum into the parietal cortex, the AS didn't develop in Wistar rats in 74% of tests. In control Wistar rats with cortical grafts or saline injections into the parietal cortex there were no significant changes in the AS development. In the experimental KM rats the grafting led to the 4-5-times increase in the AS latency. In 50% of rats it decreased the AS severity by 1-2. In the control KM rats these parameters didn't change. It was concluded that it was possible to suppress or decrease the AS development by the transplantation of the newborn striatal and cerebellar tissue into the cortex of rats predisposed to this kind of seizures.
Ermakova
I V
IV
Kuznetsova
G D
GD
Doseva
E V
EV
Petrova
E V
EV
Ioffe
M E
ME
D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D000831:Animals, Newborn; D016380:Brain Tissue Transplantation / Q000502:physiology*; D002531:Cerebellum / Q000196:embryology / Q000637:transplantation; D002540:Cerebral Cortex / Q000196:embryology / Q000637:transplantation; D003342:Corpus Striatum / Q000196:embryology / Q000637:transplantation; D016332:Fetal Tissue Transplantation / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains / Q000502:physiology*; D017208:Rats, Wistar; D011930:Reaction Time / Q000502:physiology; D012640:Seizures / Q000503:physiopathology*