[Electron microscopic study of migrating keratinocyte colonies].
Structural investigation of human migrating keratinocyte colonies in culture demonstrated cell heterogeneity in colony regions. The leading edge of the colony is surrounded by several layers of highly differentiated cells. The basal cells in the middle and front regions interplay with the help of long processes and form lamellipodia along the direction of the colony migration. Formation of the lamellipodia may be the driving force of migration. The suprabasal highly differentiated cells are elongated and flattened and form numerous desmosomes. Preserved cell contacts provide for movement of the colony as a united epithelium layer. Studies of migration of epidermal keratinocyte colonies bring light to understanding cell mechanisms of wound epithelialization and morphogenetic processes.
Voroteliak
E A
EA
Satdykova
G P
GP
Vasil'ev
A V
AV
Terskikh
V V
VV
D002454:Cell Differentiation; D002465:Cell Movement; D002469:Cell Separation; D002478:Cells, Cultured; D006801:Humans; D015603:Keratinocytes / Q000648:ultrastructure*; D008854:Microscopy, Electron