title: Neurons in the globus pallidus do not show correlated activity in the normal monkey, but phase-locked oscillations appear in the MPTP model of parkinsonism.
abstract: 1. To test the mode of functional connectivity in the basal ganglia circuitry, we studied the activity of simultaneously recorded neurons in the globus pallidus (GP) of a behaving rhesus monkey. The cross-correlograms of pairs of neurons in the GP were compared with those of neurons in the thalamus and frontal cortex and to the cross-correlograms of pallidal pairs after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment. 2. In contrast with cortical and thalamic neuronal activity, almost all pairs (n = 76/81 pairs; 93.8%, 1,629/1,651 histograms; 98.7%) of GP neurons in the normal monkey were not driven by a common input. 3. The monkey was systemically treated with MPTP until the appearance of parkinsonian signs and an intermittent 7- to 11-Hz action/postural tremor. After the MPTP treatment, many pallidal neurons (49/140; 35%) became oscillatory, and 19% (n = 31/162) of pallidal pairs had oscillatory cross-correlograms. 4. These results support the model of parallel processing in the basal ganglia of normal monkeys and suggest a breakdown of the independent activity in the parkinsonian state.
authors.affiliation: Department of Physiology, Hebrew University, Hadassah Medical School, Jerusalem, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Nini
authors.forename: A
authors.initials: A
authors.lastname: Feingold
authors.forename: H
authors.initials: H
authors.lastname: Slovin
authors.forename: H
authors.initials: H
authors.lastname: Bergman
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D004594:Electrophysiology; D005917:Globus Pallidus / Q000473:pathology / Q000503:physiopathology*; D008253:Macaca mulatta / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D009991:Oscillometry; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000503:physiopathology*; D012016:Reference Values
chemical_list: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine