Buspirone analogues as ligands of the 5-HT1A receptor. II: Capacity factors as chromatographic parameter of lipophilicity evaluation in a series of 5-HT1A and 5-HT2A receptor ligands.
The lipophilicity of a series of buspirone related agents was studied by means of reversed-phase HPLC using an octadecylsilane stationary phase a mixture of aqueous solution of sodium phosphate and methanol as a mobile phase. Comparison of the measured capacity factors with log P values has shown very good correlations with regression correlation coefficients in the range of 0.994-0.996.
Chilmonczyk
Z
Z
Pharmaceutical Research Institute, Warsaw, Poland.
Ksycińska
H
H
Cybulski
J
J
Woźniakowska-Szelejewska
A
A
D002065:Buspirone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D002138:Calibration; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D008024:Ligands; D011985:Receptors, Serotonin / Q000737:chemistry / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000737:chemistry / Q000494:pharmacology*
D007202:Indicators and Reagents; D008024:Ligands; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D002065:Buspirone