title: The concentration of light in the human lens.
abstract: OBJECTIVE
  This thesis explores the idea that light energy, especially ultraviolet light, contributes to the unequal distribution of cataract around the world and to the development of cortical opacities.
  
  
  METHODS
  In the first section, the thesis reviews historical concepts of the function of the lens and the nature of cataract, epidemiologic data on the global distribution of cataract, and clinical observations of the predominant location of cortical opacification. Second, computer ray tracings and geometric optics demonstrate the passage of light of varying angle of incidence within the lens. Third, two models of the human eye are used to study the refraction of light by the cornea and lens and illustrate the concentration of energy at the equatorial plane of the lens.
  
  
  RESULTS
  Cataract prevalence increases with proximity to the earth's equator, and cortical cataract is most common in the inferior and inferonasal lens. Theoretical studies and the eye models both demonstrate that the concentration of light within the lens increases with angle of incidence, and the eye models suggest that the inferior and inferonasal lens receives significantly more energy than other sections of the lens.
  
  
  CONCLUSIONS
  The prevalence of cataract and exposure to ultraviolet energy both increase with decreasing latitude. The most common location of cortical cataract in the inferonasal lens is consistent with the greater dose of light energy received by this portion of the lens. These studies suggest that the global distribution of cataract and the development of cortical cataract are at least in part dependent on the dose of ultraviolet light received by the lens.
authors.forename: J C
authors.initials: JC
authors.lastname: Merriam
mesh_terms: D000818:Animals; D002386:Cataract / Q000453:epidemiology / Q000209:etiology*; D003315:Cornea / Q000528:radiation effects; D004781:Environmental Exposure / Q000009:adverse effects; D005843:Geography; D014943:Global Health; D006801:Humans; D007908:Lens, Crystalline / Q000528:radiation effects*; D008953:Models, Anatomic; D015995:Prevalence; D011832:Radiation Injuries / Q000453:epidemiology / Q000209:etiology*; D011833:Radiation Injuries, Experimental / Q000453:epidemiology / Q000209:etiology; D012029:Refraction, Ocular / Q000528:radiation effects; D012542:Scattering, Radiation; D013472:Sunlight / Q000009:adverse effects; D014466:Ultraviolet Rays / Q000009:adverse effects*