title: [Mechanism of action of aspartic proteinases. 2. Conformational possibilities of an HIV-1 proteinase substrate].
abstract: Theoretical conformational analysis of a hexapeptide fragment p17-p24 of the native substrate of the HIV-1 protease was reported. The geometrical and energy parameters of all possible optimal conformations were determined. The data which are necessary for the calculation of the mechanism of the catalytic act of HIV-1 protease were obtained.
authors.forename: M E
authors.initials: ME
authors.lastname: Popov
authors.forename: I V
authors.initials: IV
authors.lastname: Kashparov
authors.forename: E M
authors.initials: EM
authors.lastname: Popov
mesh_terms: D000595:Amino Acid Sequence; D002384:Catalysis; D016333:HIV Protease / Q000378:metabolism*; D015497:HIV-1 / Q000201:enzymology*; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation; D013379:Substrate Specificity
chemical_list: D010446:Peptide Fragments; D016333:HIV Protease