title: [New aminooxy analogs of biogenic polyamines].
abstract: A series of structural analogs of putrescine, spermidine, and spermine with the aminomethylene fragment substituted by the aminooxy group was suggested. The synthesis of the new aminooxy analogs of spermine was described. Biochemical aspects of the activity of the aminooxy analogs of polyamines were discussed in respect of their selective inhibition of normal and leukemic cells.
authors.forename: A R
authors.initials: AR
authors.lastname: Khomutov
authors.forename: A S
authors.initials: AS
authors.lastname: Shvetsov
authors.forename: J
authors.initials: J
authors.lastname: Vepsalainen
authors.forename: D L
authors.initials: DL
authors.lastname: Dramer
authors.forename: T
authors.initials: T
authors.lastname: Hyvonen
authors.forename: T
authors.initials: T
authors.lastname: Keinanen
authors.forename: T O
authors.initials: TO
authors.lastname: Eloranta
authors.forename: C W
authors.initials: CW
authors.lastname: Porter
authors.forename: R M
authors.initials: RM
authors.lastname: Khomutov
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D006224:Cricetinae; D007939:Leukemia L1210 / Q000473:pathology; D011700:Putrescine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013095:Spermidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013096:Spermine / Q000031:analogs & derivatives* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D013096:Spermine; D013095:Spermidine; D011700:Putrescine