Laser Doppler perfusion imaging of proximal interphalangeal joints in patients with rheumatoid arthritis.
OBJECTIVE
A non-invasive imaging technique (laser Doppler perfusion imaging-LDI) based on measurement of backscattered Doppler-broadened near infra-red laser radiation was used to provide two-dimensional images of perfusion over the proximal interphalangeal (PIP) joints of a group of normal subjects compared to a group of patients with rheumatoid arthritis (RA).


RESULTS
Some PIP joints of the RA group showed areas of increased perfusion whereas normal subjects showed much less variation in perfusion between joints. These hyperaemic areas arose from the underlying joint, as scans taken with a less penetrating red laser did not show such areas.


CONCLUSIONS
Apart from its obvious dermatological uses, LDI could be employed to image hyperaemia associated with a variety of inflammatory conditions affecting subcutaneous structures.
Ferrell
W R
WR
Institute of Biomedical & Life Sciences, University of Glasgow, U.K.
Sturrock
R D
RD
Mallik
A K
AK
Abbot
N C
NC
Lockhart
J C
JC
Edmondson
W D
WD
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000503:physiopathology*; D001783:Blood Flow Velocity; D005260:Female; D005384:Finger Joint / Q000098:blood supply*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D017078:Laser-Doppler Flowmetry / Q000379:methods*; D008297:Male; D008875:Middle Aged