title: Neurofibrillary tangles in the dentate granule cells of patients with Alzheimer's disease, Lewy body disease and progressive supranuclear palsy.
abstract: Recent studies have shown that the dentate granular cells of the hippocampus are affected in patients with Alzheimer's disease (AD). To gain a better understanding of the cytoskeletal alterations in these cells, we carried out immunocytochemical and immunoelectron microscopic analysis of the dentate gyrus of patients with primary degenerative dementias, using a monoclonal antibody against paired helical filaments (TG3). This antibody labeled a large number of spherical inclusions in the dentate granule cells of patients with AD and its Lewy body variant (LBV). These inclusions consisted of straight tubular structures (about 18-25 nm in diameter), similar to those found in progressive supranuclear palsy (PSP). These inclusions, although in a smaller number, were also found in demented patients with PSP, but not in those with diffuse Lewy body disease or age-matched controls. These findings indicate that the neurofibrillary alterations in the dentate granule cells of patients with AD, LBV and PSP share cytoskeletal similarities.
authors.affiliation: Department of Neurosciences, University of California at San Diego, La Jolla 92093-0624, USA.
authors.forename: K
authors.initials: K
authors.lastname: Wakabayashi
authors.forename: L A
authors.initials: LA
authors.lastname: Hansen
authors.forename: I
authors.initials: I
authors.lastname: Vincent
authors.forename: M
authors.initials: M
authors.lastname: Mallory
authors.forename: E
authors.initials: E
authors.lastname: Masliah
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D000911:Antibodies, Monoclonal; D052160:Benzothiazoles; D018891:Dentate Gyrus / Q000737:chemistry / Q000473:pathology*; D005456:Fluorescent Dyes; D006801:Humans; D007150:Immunohistochemistry; D016253:Microscopy, Immunoelectron; D016874:Neurofibrillary Tangles / Q000737:chemistry / Q000473:pathology*; D010300:Parkinson Disease / Q000378:metabolism / Q000473:pathology*; D013494:Supranuclear Palsy, Progressive / Q000378:metabolism / Q000473:pathology*; D013844:Thiazoles
chemical_list: D000911:Antibodies, Monoclonal; D052160:Benzothiazoles; D005456:Fluorescent Dyes; D013844:Thiazoles; C009462:thioflavin T