title: Lymphomatoid papulosis: successful weekly pulse superpotent topical corticosteroid therapy in three pediatric patients.
abstract: Lymphomatoid papulosis is a T-cell proliferation that occurs primarily in adults but has been well described in children. Lesions may regress spontaneously but often leave residual scarring and, as a result, intervention frequently is considered. Therapeutic modalities commonly employed for adults with lymphomatoid papulosis may be poorly tolerated by pediatric patients. We present a series of three children with lymphomatoid papulosis treated with superpotent topical corticosteroids (halobetasol or clobetasol propionate). When applied twice daily for 2 to 3 weeks followed by weekly pulsed application, this treatment resulted in complete resolution of nearly all cutaneous lesions. Three ulcerated lesions, occurring in two patients, required adjuvant therapy with intralesional triamcinolone. To date one patient remains free of cutaneous disease and two children experience occasional new lesions that respond to renewed treatment with topical clobetasol propionate. None of the children have evidence of systemic disease. We conclude that pulsed application of a superpotent topical corticosteroid is efficacious and safe in the management of cutaneous lesions of lymphomatoid papulosis and avoids the risks often associated with more aggressive interventions. Since these agents do not alter the risk of subsequent malignancy, careful ongoing surveillance of children with lymphomatoid papulosis is imperative.
authors.affiliation: Department of Dermatology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Paul
authors.forename: D P
authors.initials: DP
authors.lastname: Krowchuk
authors.forename: M G
authors.initials: MG
authors.lastname: Hitchcock
authors.forename: J L
authors.initials: JL
authors.lastname: Jorizzo
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D001706:Biopsy; D002648:Child; D002990:Clobetasol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D017731:Lymphomatoid Papulosis / Q000188:drug therapy* / Q000473:pathology; D012074:Remission Induction
chemical_list: C064466:halobetasol; D002990:Clobetasol