title: CYP2E1 genotypes and serum LAP in Japanese alcoholics.
abstract: The genotypes of the ALDH2 and CYP2E1 loci of Japanese alcoholic patients were determined to investigate the susceptibility to alcoholic liver injury. In alcoholics with a liver-function disorder, a significant association was observed between the genotypes of the CYP2E1 loci and the serum level of a liver-derived enzyme, LAP. However, there was no significant association between the ALDH2 genotypes and liver dysfunction.
authors.affiliation: Department of Neuropsychiatry, Kagawa Medical School, Kita-gun, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Miyatake
authors.forename: H
authors.initials: H
authors.lastname: Suwaki
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuo
authors.forename: K
authors.initials: K
authors.lastname: Iwahashi
mesh_terms: D000437:Alcoholism / Q000201:enzymology / Q000235:genetics* / Q000503:physiopathology; D000444:Aldehyde Dehydrogenase / Q000235:genetics; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007564:Japan; D007931:Leucyl Aminopeptidase / Q000097:blood*; D008099:Liver / Q000201:enzymology / Q000503:physiopathology; D008108:Liver Diseases, Alcoholic / Q000201:enzymology / Q000235:genetics* / Q000503:physiopathology
chemical_list: D019392:Cytochrome P-450 CYP2E1; C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D007931:Leucyl Aminopeptidase