Effects of refeeding diets on emeriamine-induced fatty liver in fasting rats.
We recently reported that fatty liver and hypertriglyceridemia are easily induced by the administration of an inhibitor of fatty acid oxidation (emeriamine; (R)-3-amino-4-trimethylaminobutyric acid) to fasting rats, and that these conditions are not accompanied by the increased de novo synthesis of fatty acid [J. Nutr. Sci. Vitaminol., 42, 111-120, (1996)]. To study whether emeriamine-induced fatty liver is affected by nutrients during recovery from fatty acid oxidation inhibition, we fed rats with either a high-carbohydrate (HCHO) diet or a high-fat (HFAT) diet. Rats fed an HCHO diet following the administration of emeriamine showed a marked decrease in serum and hepatic triglycerides, and a marked increase in hepatic glycogen. The lower levels of serum and hepatic triglycerides were accompanied by decreased activities of the NADPH-generating enzymes such as malic enzyme and glucose-6-phosphate dehydrogenase. By contrast, rats fed an HFAT diet showed less significant changes in hepatic triglyceride and glycogen levels. These results suggest a reciprocal relationship between the triglyceride level and glycogen accumulation caused by HCHO diet during recovery from emeriamine.
Maeda
H
H
Faculty of Health and Living Sciences, Naruto University of Education, Japan.
Fujiwara
M
M
Miyamoto
K
K
Hamamoto
H
H
Fukuda
N
N
D000818:Animals; D001622:Betaine / Q000031:analogs & derivatives*; D002331:Carnitine; D002333:Carnitine Acyltransferases / Q000037:antagonists & inhibitors; D002784:Cholesterol / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005215:Fasting; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005234:Fatty Liver / Q000139:chemically induced*; D005502:Food; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000378:metabolism
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004791:Enzyme Inhibitors; D005230:Fatty Acids, Nonesterified; D010743:Phospholipids; D014280:Triglycerides; D001622:Betaine; D006003:Glycogen; D002784:Cholesterol; C045761:emeriamine; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D002333:Carnitine Acyltransferases; D002331:Carnitine