Surrogate end-point biomarkers as measures of colon cancer risk and their use in cancer chemoprevention trials.
Surrogate end-point biomarkers (SEBs) have become widely used in short-term cancer chemoprevention trials in place of cancer end points. This paper discusses criteria relevant to the selection and validation of SEBs for colon cancer risk and the use of SEBs in colon cancer chemoprevention trials. As with a number of other cancers, colon carcinogenesis is the result of a multistep process in which an increasing number of alterations, including specific gene mutations, occur as cells progress from normal to precancerous states of increasing size and dysplasia to cancer and finally to metastatic disease. Ideally, a SEB would show differential expression between the various phases of colon carcinogenesis (i.e., normal, premalignant, and malignant tissues) and be associated with risk of colon cancer. Some SEBs that do not meet these criteria may still be useful for demonstrating the effect of a particular agent. It is also necessary that a SEB be measured in tissues (or other sample material) accessible for multiple and sequential sampling and allow for development of appropriate quality control procedures. Some SEBs must have the potential for modulation by chemopreventive agents. Validation of SEBs for use in chemoprevention studies requires that a relationship between the marker and subsequent risk of cancer be established. Also, the assay reliability and accuracy for each SEB must be determined adequately in well-designed prospective studies.
Einspahr
J G
JG
University of Arizona Cancer Biology Graduate Program, Arizona Cancer Center, Tucson 85724, USA.
Alberts
D S
DS
Gapstur
S M
SM
Bostick
R M
RM
Emerson
S S
SS
Gerner
E W
EW
D017209:Apoptosis; D016718:Arachidonic Acid / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000032:analysis*; D018890:Chemoprevention; D003110:Colonic Neoplasms / Q000209:etiology* / Q000517:prevention & control*; D006801:Humans; D008940:Mitotic Index; D009154:Mutation; D011073:Polyamines / Q000378:metabolism; D011230:Precancerous Conditions / Q000150:complications; D015203:Reproducibility of Results; D012307:Risk Factors
D014408:Biomarkers, Tumor; D011073:Polyamines; D016718:Arachidonic Acid