title: [Introduction of definite molecular weight heparan sulfate in a protocol of prevention of deep venous thrombosis in prosthetic orthopedic surgery].
abstract: Use of definite molecular weight heparan sulphate in a protocol for the prevention of deep venous thrombosis in the total joint replacement surgery. The authors propose a working protocol for the prevention of deep venous thrombosis in prosthetic orthopaedic surgery. It requires that integration of pharmacological, anaesthesiological, rheological and physiokinesitherapic measures, it has permitted a very good prevention of thromboembolic disease and it is well-tolerated and safe. The protocol requires: peripheral anaesthesia (sub-arachnoidal block), pre and post-operative pharmacological treatment with heparan-sulphate of a fixed molecular weight, haemodilution with maintenance of the haematocrit at no more than 30%, early physiokinesitherapy associated with the use of elastic stockings graduated tension. The fifty patients treated with this protocol were controlled during the pre-operative and post-operative stage and one month later and no thrombo-embolic complications resulted.
authors.affiliation: UO Anestesia e Rianimazione, USL 8-Zona Valdarno Montevarchi (Arezzo).
authors.forename: M
authors.initials: M
authors.lastname: Mandò
authors.forename: G P
authors.initials: GP
authors.lastname: Margiacchi
authors.forename: R
authors.initials: R
authors.lastname: Alioto
authors.forename: L
authors.initials: L
authors.lastname: Ferri
authors.forename: F
authors.initials: F
authors.lastname: Bernardoni
authors.forename: G
authors.initials: G
authors.lastname: Alberti
authors.forename: A
authors.initials: A
authors.lastname: Teti
authors.forename: L D
authors.initials: LD
authors.lastname: Simone
authors.forename: M
authors.initials: M
authors.lastname: Bardelli
mesh_terms: D000368:Aged; D001458:Bandages; D005081:Exercise Therapy; D005260:Female; D006497:Heparan Sulfate / Q000627:therapeutic use*; D006622:Hip Prosthesis; D006801:Humans; D007720:Knee Prosthesis; D008297:Male; D008970:Molecular Weight; D011183:Postoperative Complications / Q000517:prevention & control*; D013924:Thrombophlebitis / Q000517:prevention & control*
chemical_list: D006497:Heparan Sulfate