Effects of cell cycle specific exposure to 3H-thymidine or 3H-arginine on development and cell proliferation of mouse embryos.
One-cell mouse embryos were exposed to either 3H-thymidine (100 or 200 kBq/ml) or 3H-arginine (2.5 to 50 kBq/ml) for 2 h either in G1, S or G2 phase. 3H-Arginine affected embryonic development and cell proliferation in an activity-dependent way irrespective of the cell cycle stage exposed, whereas 3H-thymidine was effective only at higher activities and only after exposure during S phase.
Müller
W U
WU
Institut für Medizinische Strahlenbiologie, Universitätsklinikum Essen, Germany.
Heckeley
N
N
Streffer
C
C
D000818:Animals; D001120:Arginine / Q000378:metabolism*; D002453:Cell Cycle; D002455:Cell Division / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000528:radiation effects*; D005260:Female; D008297:Male; D051379:Mice; D013936:Thymidine / Q000378:metabolism*; D014316:Tritium / Q000633:toxicity*
D014316:Tritium; D001120:Arginine; D013936:Thymidine