title: Vitreous changes during ocular inflammation induced by interleukin 1 beta.
abstract: To determine the mechanisms of vitreous changes during ocular inflammation, we investigated these changes, focusing on the collagen, in an experimental model of ocular inflammation induced by intravitreal injection of interleukin 1 beta in rabbits. Inflammation caused gel contraction, with release of a watery liquid from the gel, and increases in the amount of insoluble material and high-molecular-weight components of the vitreous collagen, presumably due to extensive cross-links of the collagen molecules. The cross-links of vitreous collagen may promote vitreous gel contraction and the release of watery liquid from the gel.
authors.affiliation: Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, USA.
authors.forename: T
authors.initials: T
authors.lastname: Hikichi
authors.forename: N
authors.initials: N
authors.lastname: Ueno
authors.forename: B
authors.initials: B
authors.lastname: Chakrabarti
authors.forename: C L
authors.initials: CL
authors.lastname: Trempe
mesh_terms: D000818:Animals; D001834:Body Water / Q000378:metabolism; D003094:Collagen / Q000378:metabolism*; D004195:Disease Models, Animal; D004591:Electrophoresis, Polyacrylamide Gel; D009877:Endophthalmitis / Q000139:chemically induced / Q000378:metabolism*; D005136:Eye Proteins / Q000378:metabolism; D007375:Interleukin-1 / Q000633:toxicity*; D008297:Male; D008970:Molecular Weight; D011817:Rabbits; D014822:Vitreous Body / Q000378:metabolism*
chemical_list: D005136:Eye Proteins; D007375:Interleukin-1; D003094:Collagen