Piracetam and fipexide prevent PTZ-kindling-provoked amnesia in rats.
Deficit in active and inhibitory avoidance behaviour has been pentylenetetrazole (PTZ)-kindled rats. This supports the view that memory deficit is an integral part of epilepsy. In the present study we examined the effect of the nootropic drugs piracetam and fipexide on memory deficit induced by PTZ-kindling in shuttle-box- and step-down-trained rats. The retention in piracetam- and fipexide-treated animals was significantly improved compared to the kindled controls. The mechanisms of action of the two drugs are considered. The favourable of nootropic drugs in cases of amnesia provoked by PTZ-kindling might be of interest in clinical practice.
Genkova-Papazova
M G
MG
Laboratory of CNS Pharmacology, Institute of Physiology, Bulgarian Academy of Sciences, sofia, Bulgaria.
Lazarova-Bakarova
M B
MB
D000647:Amnesia / Q000188:drug therapy*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D010433:Pentylenetetrazole / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology*; D010889:Piracetam / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D010879:Piperazines; C038628:fipexide; D010433:Pentylenetetrazole; D010889:Piracetam