title: The diagnostic value of Tc-99m human polyclonal immunoglobulin imaging compared to Tc-99m HMPAO labeled leukocytes in inflammatory bowel disease.
abstract: The aim of this study was to establish the usefulness of Tc-99m human polyclonal immunoglobulin (HIG) imaging in a group of patients who were suspected of having inflammatory bowel disease (IBD). The authors performed 30 scans (15 with Tc-99m HMPAO leukocytes and 15 with Tc-99m HIG) on 15 patients with IBD. Ten patients had Crohn's disease and five had ulcerative colitis. The sensitivity of Tc-99m HIG scintigraphy for detecting IBD was 33%, while the sensitivity of Tc-99m HMPAO leukocyte imaging was 100%. The Tc-99m HMPAO leukocyte imaging also detected a larger number of affected segments and provided better image quality of the extent of disease than Tc-99m HIG. On the basis of these results, the authors believe that Tc-99m HIG imaging is not a useful technique in the evaluation of patients with IBD, in the identification of location, or the extension or degree of disease activity.
authors.affiliation: Nuclear Medicine Department of the University Teaching Hospital, Zaragoza, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Delgado Castro
authors.forename: C
authors.initials: C
authors.lastname: Lancha
authors.forename: E
authors.initials: E
authors.lastname: Prats
authors.forename: M
authors.initials: M
authors.lastname: Mitjavilla
authors.forename: D
authors.initials: D
authors.lastname: Abós
authors.forename: L M
authors.initials: LM
authors.lastname: Martín-Curto
authors.forename: A
authors.initials: A
authors.lastname: Crespo
authors.forename: J
authors.initials: J
authors.lastname: Banzo
mesh_terms: D003093:Colitis, Ulcerative / Q000000981:diagnostic imaging*; D003424:Crohn Disease / Q000000981:diagnostic imaging*; D006801:Humans; D007136:Immunoglobulins; D007962:Leukocytes; D015609:Organotechnetium Compounds; D010091:Oximes; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D013667:Technetium; D019690:Technetium Tc 99m Exametazime; D013997:Time Factors
chemical_list: D007136:Immunoglobulins; D015609:Organotechnetium Compounds; D010091:Oximes; C065376:technetium Tc 99m immunoglobulin; D019690:Technetium Tc 99m Exametazime; D013667:Technetium