[The effect of bacterial polysaccharides on the course of a Mycoplasma infection].
Polysaccharides of Clavibacter michiganense have been studied for their effect on Mycoplasma infection. It is established that content of T-lymphocytes truthfully increased in the groups of animals whose PS 1 and PS 2 were administered both with protective and medical purpose as compared with that in a group of animals with natural course of mycoplasmosis. Under these conditions the effect of polysaccharides on T-helpers were not evidently expressed, while they exerted considerable effect on T-suppressors, normalizing their high index in the animals infected by Mycoplasma hominis. Polysaccharides also exerted a normalizing effect on the content of T-killers, whose level in the animals with natural proceeding of mycoplasmosis was considerably decreased. One can observe a decrease of content of B-lymphocytes (which approached the level of their control in a group of conditionally healthy animals) under the effect of polysaccharides as compared to infected animals. Metabolic processes are activated in immunocompetent cells as affected by polysaccharide. Results obtained when studying the effect of polysaccharides on immunologic factors in the animals with mycoplasma infection as well as histomorphological data confirm the above evidences that polysaccharides of C. michiganense are promising immunomodulators.
Rudenko
A V
AV
Varbanets
L D
LD
D000276:Adjuvants, Immunologic / Q000302:isolation & purification / Q000627:therapeutic use*; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D004353:Drug Evaluation, Preclinical; D007111:Immunity, Cellular / Q000187:drug effects; D051379:Mice; D009175:Mycoplasma Infections / Q000188:drug therapy* / Q000276:immunology; D019535:Mycoplasma hominis; D011135:Polysaccharides, Bacterial / Q000302:isolation & purification / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D011135:Polysaccharides, Bacterial