Simultaneous 3D NMR spectroscopy of proton-decoupled fluorine and phosphorus in human liver during 5-fluorouracil chemotherapy.
Simultaneous acquisition of 1H-decoupled 31P and 19F 3D CSI is demonstrated in the liver of a patient undergoing 5-fluorouracil chemotherapy. Both 31P and 19F shared the same voxel size (64 or 27 ml), bi-level 1H-decoupling and 0.35 s TR. The measurements were done in a 1.5 Tesla clinical imager with three radio-frequency (RF) channels and a triple-tuned surface-coil. The overall MRI and MRS examination time was under 90 min. Simultaneous acquisition of 31P and 19F permits localized study of the influence of hepatic metabolism on the uptake and catabolism of fluoropyrimidine drugs without extra measurement time or higher SAR.
Gonen
O
O
Department of NMR and Medical Spectroscopy, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
Murphy-Boesch
J
J
Li
C W
CW
Padavic-Shaller
K
K
Negendank
W G
WG
Brown
T R
TR
D000042:Absorption; D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000378:metabolism / Q000493:pharmacokinetics / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000601:surgery; D005461:Fluorine / Q000032:analysis*; D005472:Fluorouracil / Q000378:metabolism / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D006859:Hydrogen; D007089:Image Enhancement / Q000295:instrumentation / Q000379:methods; D008099:Liver / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods; D008297:Male; D019047:Phantoms, Imaging; D010758:Phosphorus / Q000032:analysis*; D013997:Time Factors
D000964:Antimetabolites, Antineoplastic; D010758:Phosphorus; D005461:Fluorine; D006859:Hydrogen; D005472:Fluorouracil