title: Sudden deafness: a comparison of anticoagulant therapy and carbogen inhalation therapy.
abstract: Sudden deafness (SD) is a sudden or rapidly progressive, partial or complete, typically unilateral sensorineural hearing impairment that has no known specific etiologic factor. This study was designed to compare, in a group of 168 consecutive patients with SD, the effect of anticoagulant therapy and carbogen inhalation therapy. Special attention was paid to the shape of the audiogram relative to the clinical outcome and the treatment modality. We found that the configuration of the audiogram of SD patients is prognostic of the outcome, and that patients with a low-frequency-sloping hearing impairment have a better prognosis compared to the patients with a high-sloping loss. Anticoagulant treatment was most effective in low-sloping hearing losses, while carbogen inhalation may be more effective for patients with high-sloping hearing losses.
authors.affiliation: Dept of Otorhinolaryngology, Turku University Central Hospital, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Kallinen
authors.forename: E
authors.initials: E
authors.lastname: Laurikainen
authors.forename: P
authors.initials: P
authors.lastname: Laippala
authors.forename: R
authors.initials: R
authors.lastname: Grénman
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D001301:Audiometry, Pure-Tone; D002245:Carbon Dioxide / Q000008:administration & dosage*; D002648:Child; D005260:Female; D003639:Hearing Loss, Sudden / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000008:administration & dosage*
chemical_list: D000925:Anticoagulants; D002245:Carbon Dioxide; C011700:carbogen; D010100:Oxygen