title: Family history as a marker of risk for colorectal cancer: Austrian experience.
abstract: A family history of colorectal cancer is a known risk factor for the disease. As a result of different study designs from different populations, the strength of this association varies in the literature. We intended to define the incidence and the risk predictors in first-degree relatives of patients with colorectal cancer in the Austrian population. A family history was obtained from first-degree relatives of 100 consecutive patients with sporadic colorectal cancer. Life-table methods were used to compare the observed and expected incidence of colorectal cancer and the influence of differences in risk for first-degree family members. The calculated lifetime risk for colorectal cancer in Austria is 1:16. Individuals with a positive family history had a 4.6-fold risk (p </= 0.0001), particularly in the case of a young index patient (p </= 0.011) or if two or more family members were affected (p </= 0. 001). In addition, the risk for gastric cancer in relatives was increased almost fourfold (p </= 0.0001). We have confirmed for Austria that a positive family history of colorectal cancer is a strong risk factor, and that this risk is comparable to that in other Western countries. We have shown that relatives are also at increased risk for gastric cancer.
authors.affiliation: Department of Surgery, University of Vienna Medical School, Währingergürtel, 18-20, A-1090, Vienna, Austria.
authors.forename: J
authors.initials: J
authors.lastname: Karner-Hanusch
authors.forename: M
authors.initials: M
authors.lastname: Mittlböck
authors.forename: T
authors.initials: T
authors.lastname: Fillipitsch
authors.forename: F
authors.initials: F
authors.lastname: Herbst
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001317:Austria / Q000453:epidemiology; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D005190:Family; D005260:Female; D006801:Humans; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D012307:Risk Factors