title: Prevalence of primary Helicobacter pylori resistance to metronidazole and clarithromycin in The Netherlands.
abstract: The minimum inhibitory concentrations of metronidazole and clarithromycin were determined for 780 Helicobacter pylori strains collected in 1994 and 1995 from three different regions in The Netherlands. The overall prevalence of primary metronidazole resistance was 17%, with resistance found more frequently in women (24%) than in men (13%). There was no significant difference between the levels of resistance in the three regions. Primary clarithromycin resistance was rare (1%) and relatively infrequent as compared to that found in other countries. Four of the six strains resistant to clarithromycin were also resistant to metronidazole.
authors.affiliation: Regional Public Health Laboratory Groningen/Drenthe, The Netherlands.
authors.forename: A A
authors.initials: AA
authors.lastname: van Zwet
authors.forename: W A
authors.initials: WA
authors.lastname: de Boer
authors.forename: P M
authors.initials: PM
authors.lastname: Schneeberger
authors.forename: J
authors.initials: J
authors.lastname: Weel
authors.forename: A R
authors.initials: AR
authors.lastname: Jansz
authors.forename: J C
authors.initials: JC
authors.lastname: Thijs
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017291:Clarithromycin / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015337:Multicenter Studies as Topic; D009426:Netherlands; D015995:Prevalence
chemical_list: D000900:Anti-Bacterial Agents; D008795:Metronidazole; D017291:Clarithromycin