Peripheral blood lymphocyte subsets in idiopathic nephrotic syndrome of childhood.
Lymphocyte subsets in the peripheral blood were examined in 34 patients with nephrotic syndrome [27 with minimal change nephrotic syndrome (MCNS), 7 with significant lesions] and 10 normal children. The investigations were done at the onset of disease before administering corticosteroids (n = 34), during the subsequent remission (n = 27), and the first relapse (n = 12). The proportions of T cell subsets (CD3, CD4 and CD8) were determined by immuno-alkaline phosphatase staining; interleukin-2 receptor (IL-2 R) positive cells, natural killer (NK) cells and B cells were studied by indirect immunofluorescence. No significant differences were found in the proportion of CD3, CD4, CD8 and IL-2 R positive cells in patients with MCNS as compared to controls. An increased proportion of NK and B cells was not specific to MCNS and was detected even in those with significant renal lesions. Our findings suggest that T lymphocyte subsets in MCNS are similar to those in normal children.
Bagga
A
A
Department of Paediatrics, All India Institute of Medical Sciences, New Delhi.
Vasudev
A S
AS
Moudgil
A
A
Srivastava
R N
RN
D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D016131:Lymphocyte Subsets; D008297:Male; D009402:Nephrosis, Lipoid / Q000097:blood* / Q000209:etiology / Q000276:immunology; D009404:Nephrotic Syndrome / Q000097:blood* / Q000209:etiology / Q000276:immunology