title: The effects of long-term administration of guarana on the cognition of normal, elderly volunteers.
abstract: Paulinia cupana (guarana) is a Brazilian plant given great prestige in popular medicine, for example as being a potent stimulator of brain functions. The authors assessed the effects of the long-term administration of guarana on the cognition of normal, elderly volunteers. Forty-five volunteers were studied, with a random distribution in three experimental groups: placebo (n = 15), caffeine (n = 15), and guarana (n = 15), in a double-blind study. There were no significant cognitive alterations in these volunteers.
authors.affiliation: Brazilian Information Center on Psychotropic Drugs of the Department of Psychobiology, Federal University of São Paulo, Brazil.
authors.forename: J C
authors.initials: JC
authors.lastname: Galduróz
authors.forename: E A
authors.initials: EA
authors.lastname: Carlini
mesh_terms: D000368:Aged; D001007:Anxiety; D001288:Attention; D002110:Caffeine / Q000009:adverse effects; D003071:Cognition; D004311:Double-Blind Method; D005260:Female; D005638:Fruit / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008568:Memory; D008875:Middle Aged; D010946:Plants, Medicinal; D011597:Psychomotor Performance; D012890:Sleep; D013028:Space Perception; D013997:Time Factors; D014796:Visual Perception
chemical_list: D002110:Caffeine