Endometrial biopsy collection from women receiving Norplant.
A series of 191 endometrial biopsy procedures were performed on Indonesian women who had received between 3 and 12 months exposure to Norplant. In all, 87 biopsy procedures were attempted with a microhysteroscope using biopsy forceps, and 104 procedures were attempted with either Pipelle or Karman suction curettes. Regardless of the biopsy method, diagnosable endometrium was obtained in only approximately 50% of procedures. Myometrium was often found in microhysteroscope but not in suction biopsies. An analysis of a number of clinical characteristics showed that women from whom diagnosable endometrial tissue was obtained had higher mean peripheral oestrogen concentrations in the 2 weeks prior to biopsy (439 +/- 35 versus 289 +/- 33 pmol/l; P = 0.0018) and significantly more days when endometrial bleeding occurred in the 90 days prior to biopsy (26.5 +/- 2.1 versus 16.2 +/- 1.8; P = 0.0003). These results suggest that after 3-12 months exposure to Norplant approximately 50% of women have an endometrium too thin to sample, and that this group is characterized by lower peripheral oestrogen concentrations and reduced menstrual bleeding.
Hadisaputra
W
W
Klinik Raden Saleh, J.L. Raden Saleh Raya 49, Jakarta, Indonesia.
Affandi
B
B
Witjaksono
J
J
Rogers
P A
PA
D001706:Biopsy / Q000379:methods; D003271:Contraceptive Agents, Female / Q000009:adverse effects*; D004717:Endometrium / Q000187:drug effects / Q000473:pathology*; D004967:Estrogens / Q000097:blood / Q000378:metabolism; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D007214:Indonesia; D016912:Levonorgestrel / Q000009:adverse effects*
D003271:Contraceptive Agents, Female; D004967:Estrogens; D016912:Levonorgestrel