Human papillomavirus in normal cervical smears from Cape Town.
OBJECTIVE
To determine the prevalence of human papillomavirus (HPV) types in South African women with normal cervical cytology and to determine whether our results are comparable to what has been found elsewhere in the world.


METHODS
Cervical smears were collected from 262 women.


METHODS
The Cape Town metropolitan area.


METHODS
A total of 262 women, aged 19-85 years. Eighty-five women attended the family planning clinic of the Gynaecology Department at Groote Schuur Hospital and 177 women consulted private gynaecological practices.


METHODS
The prevalence and types of HPV in 192 women with normal cervical cytology.


RESULTS
The incidence of HPV DNA in cervical smears from Cape Town women with normal cytology was found to be 13% (25/192) using Southern blot hybridisation. The types of HPV found in normal cervical tissue from Cape Town did not differ significantly from those found elsewhere in the world. Nine per cent (17/192) were positive for "high-risk' HPV types which are associated with premalignant and malignant cervical lesions. In the age group 20-39 years, 15 of 92 (16%) were positive for HPV DNA, while in the age group above 39 years, 3 of 53 (6%) women were positive for HPV DNA.


CONCLUSIONS
In this study, 25 of 192 (13%) women with normal cytology were positive for HPV.
Ramesar
J E
JE
Department of Medical Microbiology, University of Cape Town.
Dehaeck
C M
CM
Soeters
R
R
Williamson
A L
AL
D015139:Blotting, Southern; D002584:Cervix Uteri / Q000166:cytology*; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology; D017422:Sequence Analysis, DNA; D013019:South Africa; D014626:Vaginal Smears
D004279:DNA, Viral