Antiphospholipid-protein antibodies: clinical use of laboratory test results (identification, predictive value, treatment).
Antiphospholipid-protein antibodies (APA) are a family of immunoglobulins which recognize protein-phospholipid complexes. Among the proteins implicated are: beta 2 Glycoprotein I, prothrombin, Annexin V, protein C, and protein S. Laboratory tests are used to identify, predict potential clinical complications, and manage patients with the antiphospholipid-protein syndrome (APS). Emerging evidence suggests laboratory tests can be used to stratify relative risk of patients with APA.
Triplett
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Ball Memorial Hospital, Muncie, Indiana 47303, USA.
D017152:Antibodies, Antiphospholipid / Q000097:blood* / Q000145:classification; D016736:Antiphospholipid Syndrome / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D001327:Autoimmune Diseases / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D015151:Immunoblotting / Q000379:methods; D007239:Infections / Q000150:complications / Q000276:immunology; D007518:Isoantibodies / Q000097:blood / Q000276:immunology; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology; D009369:Neoplasms / Q000150:complications / Q000276:immunology; D017410:Practice Guidelines as Topic; D011237:Predictive Value of Tests; D011486:Protein C / Q000502:physiology; D012306:Risk; D013927:Thrombosis / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D053482:beta 2-Glycoprotein I
D017152:Antibodies, Antiphospholipid; D006023:Glycoproteins; D007518:Isoantibodies; D016682:Lupus Coagulation Inhibitor; D011486:Protein C; D053482:beta 2-Glycoprotein I