Efficacy of Cymbopogon giganteus and Enantia chrantha against chloroquine resistant Plasmodium yoelii nigeriensis.
The antimalarial activity of boiled water extracts of two medicinal plants (Cymbopogon giganteus and Enantia chlorantha) against chloroquine resistant Plasmodium yoelii nigeriensis in albino mice was assessed. Twenty-five mice were used for each extract. Each mouse was inoculated with approximately 10(5) erythrocytes infected with chloroquine-resistant P.y. nigeriensis. At five to seven percent parasitaemia, the mice were randomly divided into five groups of five mice each. The first four groups were treated intraperitoneally for three consecutive days with different doses of the stock solution per mouse. The two extracts cleared the infection in a dose-dependent manner.
Kimbi
H K
HK
Department of Medical Microbiology and Parasitology, College of Medicine, University of Lagos, Nigeria.
Fagbenro-Beyioku
A F
AF
D000818:Animals; D002738:Chloroquine; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance; D008288:Malaria / Q000188:drug therapy*; D016488:Medicine, African Traditional; D051379:Mice; D009549:Nigeria; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal; D010967:Plasmodium yoelii; D011897:Random Allocation
D010936:Plant Extracts; D002738:Chloroquine