Two year old hepatitis A vaccine is as good as new.
This was a randomized, controlled, double-blind study assessing the reactogenicity and immunogenicity of newly produced vs 2 year old hepatitis A vaccine. Overall 215 non-immune volunteers, 18-39 years old were divided into four groups and administered vaccine at months 0, 1 and 6. Three groups each received a different vaccine lot which had been stored at 4 degrees C for 2 years, and one group received recently produced vaccine as control. The mean local and general adverse reaction rates were 59.1% and 17.4%, respectively, and all vaccinees had seroconverted by month 2. There were no significant differences in geometric mean anti-hepatitis A virus (HAV) antibody titres between the four groups. In conclusion 2 year old HAV vaccine is safe and equally immunogenic as newly produced vaccine.
Rajan
E
E
Department of Medicine, Royal College of Surgeons, Dublin, Ireland.
al Bloushi
S
S
O'Farrell
B
B
Shattock
A
A
Courtney
M G
MG
Safary
A
A
Fielding
J F
JF
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D004311:Double-Blind Method; D004355:Drug Stability; D005260:Female; D022362:Hepatitis A Vaccines; D006507:Hepatovirus; D006801:Humans; D008297:Male; D010146:Pain / Q000209:etiology; D014761:Viral Hepatitis Vaccines / Q000009:adverse effects / Q000276:immunology* / Q000627:therapeutic use
D000914:Antibodies, Viral; D022362:Hepatitis A Vaccines; D014761:Viral Hepatitis Vaccines