title: Provocative growth hormone testing is not required before initiation of rhGH treatment in children with renal and liver transplants.
abstract: GH provocative testing does not predict subsequent growth response, and is not therefore required before initiation of rhGH treatment in children with renal and liver transplants. However, therapeutic doses of glucocorticoids may potentially inhibit GH secretion in some patients, and determining GH secretory status by provocation tests and measuring spontaneous GH secretion is advisable at some point after organ Tx to exclude GH deficiency.
authors.affiliation: Children's Hospital, University of Helsinki, Finland.
authors.forename: S
authors.initials: S
authors.lastname: Sarna
authors.forename: K
authors.initials: K
authors.lastname: Ronnholm
authors.forename: I
authors.initials: I
authors.lastname: Sipila
authors.forename: C
authors.initials: C
authors.lastname: Holmberg
mesh_terms: D000293:Adolescent; D001120:Arginine; D002648:Child; D002675:Child, Preschool; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy* / Q000503:physiopathology; D013006:Growth Hormone / Q000378:metabolism; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007328:Insulin; D016030:Kidney Transplantation; D016031:Liver Transplantation; D008297:Male; D011237:Predictive Value of Tests; D016896:Treatment Outcome
chemical_list: D007328:Insulin; D019382:Human Growth Hormone; D013006:Growth Hormone; D001120:Arginine