title: Early diagnosis in Parkinson's disease--limitation of biochemical markers and instrumental methods.
abstract: For most cases of Parkinson's disease (PD) we can estimate the time lag from the first onset of unspecific complaints until diagnosis by case history to be about 2 years. Until now the exact course of neurodegeneration in PD is still unknown. On base of recent knowledge we can discuss different models for the development of PD. There are substantially different possible approaches to recognise PD as soon as possible. The time interval for an earlier diagnosis is different for these methods and depends on the real course of neurodegerdation.
authors.affiliation: Department of Neurology, St. Josef Hospital, Bochum, Federal Republic of Germany.
authors.forename: P H
authors.initials: PH
authors.lastname: Kraus
mesh_terms: D001058:Apomorphine; D015415:Biomarkers; D016923:Cell Death; D003342:Corpus Striatum / Q000473:pathology; D003952:Diagnostic Imaging; D004594:Electrophysiology; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D009410:Nerve Degeneration; D010300:Parkinson Disease / Q000175:diagnosis* / Q000473:pathology; D013378:Substantia Nigra / Q000473:pathology; D013997:Time Factors
chemical_list: D015415:Biomarkers; D007980:Levodopa; D001058:Apomorphine