title: Membranous lupus nephritis with antineutrophil cytoplasmic antibody-associated segmental necrotizing and crescentic glomerulonephritis.
abstract: Focal segmental necrotizing and crescentic lupus nephritis accompanied by perinuclear antineutrophil cytoplasmic antibody (P-ANCA) seropositivity is an unusual occurrence. We report the first biopsy-documented cases of membranous lupus nephritis class V with associated "pauci-immune" segmental necrotizing glomerulonephritis and P-ANCA seropositivity. The absence of subendothelial electron-dense deposits favored a manifestation of superimposed ANCA-associated glomerulonephritis rather than class III lupus nephritis. The pathogenetic implications of this association are explored.
authors.affiliation: Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
authors.forename: S
authors.initials: S
authors.lastname: Marshall
authors.forename: R
authors.initials: R
authors.lastname: Dressler
authors.forename: V
authors.initials: V
authors.lastname: D'Agati
mesh_terms: D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D005923:Glomerulosclerosis, Focal Segmental / Q000175:diagnosis*; D006801:Humans; D007668:Kidney / Q000473:pathology; D008181:Lupus Nephritis / Q000175:diagnosis*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic