title: Coronary vein flow velocity changes during transluminal balloon angioplasty: a study using the Doppler guide wire.
abstract: The coronary flow velocity changes in the great cardiac and middle cardiac veins, induced by intracoronary administration of nitroglycerine, adenosine, and during percutaneous transluminal coronary angioplasty, were evaluated in 12 patients with significant coronary stenoses, using the Doppler wire (Flowire). Optimal spectral signals of the time-averaged peak flow velocity were obtained in 10 patients. Nitroglycerine produced no significant flow velocity changes (P = 0.13). Adenosine caused a significant augmentation of flow velocity compared to baseline (P = 0.003). During balloon inflation, venous flow velocity decreased (P = 0.007); however, the venous outflow did not cease. A pronounced venous hyperemic response, following balloon deflation, was also documented. The utility of continuous vein flow velocity monitoring with the Flowire, during high-risk and complicated coronary interventions remains to be elucidated.
authors.affiliation: Onassis Cardiac Surgery Center, Cardiology Department, Kallithea, Athens, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Manginas
authors.forename: G
authors.initials: G
authors.lastname: Pavlides
authors.forename: V
authors.initials: V
authors.lastname: Voudris
authors.forename: V
authors.initials: V
authors.lastname: Vassilikos
authors.forename: D V
authors.initials: DV
authors.lastname: Cokkinos
mesh_terms: D000241:Adenosine / Q000008:administration & dosage; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D001783:Blood Flow Velocity / Q000502:physiology; D006328:Cardiac Catheterization; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000502:physiology; D003327:Coronary Disease / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D015552:Injections, Intralesional / Q000295:instrumentation; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000295:instrumentation* / Q000379:methods; D005996:Nitroglycerin / Q000008:administration & dosage; D014665:Vasodilator Agents / Q000008:administration & dosage
chemical_list: D014665:Vasodilator Agents; D005996:Nitroglycerin; D000241:Adenosine