Bupropion induces sniffing: a possible dopaminergic mechanism.
The effect of bupropion, an antidepressant drug, on sniffing behaviour was examined in rats. Animals treated intraperitoneally (i.p.) with different doses of bupropion (5-40 mg/kg) showed sniffing behaviour in a dose-related manner. Pretreatment of animals (i.p.) with the dopamine antagonists SCH 23390 (0.025-0.1 mg/kg) or sulpiride (12.5-50 mg/kg) decreased the sniffing induced by bupropion. Reserpine pretreatment (2.5 mg/kg, i.p., 18 h) alone and in combination with alpha-methyl-p-tyrosine (AMPT; 250 mg/kg, i.p.) also reduced the behaviour produced by the drug. The alpha-adrenoceptor phenoxybenzamine (5 and 10 mg/kg, i.p.) and the beta-adrenoceptor antagonist propranolol (5 and 10 mg/kg, i.p.) administered 60 min prior to bupropion did not affect the drug's effect on sniffing. Propranolol alone, however, induced sniffing. The antimuscarinic atropine (5 and 10 mg/kg, i.p.) administered 30 min prior to bupropion increased the bupropion response. Atropine alone induced vigorous sniffing. It is concluded that bupropion induced sniffing through a dopaminergic mechanism.
Zarrindast
M R
MR
Department of Pharmacology, School of Medicine, University of Tehran, Iran.
Hodjati
M R
MR
Pejhan
A
A
Soleimannejad
E
E
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001552:Benzazepines / Q000494:pharmacology; D016642:Bupropion / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D012119:Respiration / Q000187:drug effects*
D001552:Benzazepines; D016642:Bupropion; D004298:Dopamine