title: Monitoring growth during orthodontic treatment.
abstract: The relationship between somatic growth and orthodontic treatment has been limited to the evaluation of body height and skeletal age relative to craniofacial development. The aim of this study was to evaluate the correlation of anthropometric and biochemical measures of general growth with facial and occlusal changes during the early treatment of Class II Division 1 malocclusion. Findings are reported from 46 children, ages 7.20 to 12.85 years (skeletal ages, 5.75 to 12.75 years), who are enrolled in a prospective clinical trial. Body and knee heights were measured monthly, with a Holtain stadiometer and a Knee Height Measuring Device, respectively. Every three months, serum levels were measured of the hormone dehydroepiandrosterone sulfate (DHEAS), an androgen associated with growth in midchildhood, and osteocalcin, an indicator of bone turnover. Significant correlations existed between knee height and various occlusal measurements, but mandibular length was not significantly correlated with knee height and DHEAS levels. Knee height correlated significantly (P < .05) with DHEAS and osteocalcin only in 46% and 37% of the children, respectively. The results indicate that the evaluated biochemical measures, at the time intervals considered, may not increase the accuracy of growth depiction by physical measures alone (height and skeletal maturation).
authors.affiliation: Department of Orthodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia 19104-6003, USA.
authors.forename: J G
authors.initials: JG
authors.lastname: Ghafari
authors.forename: F S
authors.initials: FS
authors.lastname: Shofer
authors.forename: L L
authors.initials: LL
authors.lastname: Laster
authors.forename: D L
authors.initials: DL
authors.lastname: Markowitz
authors.forename: S
authors.initials: S
authors.lastname: Silverton
authors.forename: S H
authors.initials: SH
authors.lastname: Katz
mesh_terms: D000886:Anthropometry; D015415:Biomarkers; D001827:Body Height; D002648:Child; D003687:Dehydroepiandrosterone / Q000032:analysis / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D005115:Extraoral Traction Appliances; D005260:Female; D006128:Growth; D006801:Humans; D007866:Leg / Q000254:growth & development; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D008310:Malocclusion / Q000628:therapy*; D008445:Maxillofacial Development; D017289:Orthodontic Appliances, Functional; D009971:Orthodontics, Corrective / Q000379:methods; D015675:Osteocalcin / Q000097:blood; D011446:Prospective Studies; D012463:Saliva / Q000737:chemistry; D012727:Sex Characteristics
chemical_list: D015415:Biomarkers; D015675:Osteocalcin; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate