Does ibuprofen affect bilirubin-albumin binding in newborn infant serum?
Intravenous ibuprofen is being studied in sick, premature infants for the prevention of intraventricular haemorrhage and closure of the ductus arteriosus. We tested the effect of ibuprofen on bilirubin-albumin binding in adult and newborn infant serum by measuring the free ibuprofen concentration in the presence of bilirubin (reverse displacement method). At clinically appropriate ibuprofen concentrations the free fraction of bilirubin is increased by a factor of 4. Ibuprofen may increase the risk of bilirubin encephalopathy when used in sick, premature infants.
Cooper-Peel
C
C
Department of Pediatrics, East Carolina University School of Medicine, Greenville, NC 27858-4354, USA.
Brodersen
R
R
Robertson
A
A
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001663:Bilirubin / Q000378:metabolism*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology*; D007231:Infant, Newborn; D011485:Protein Binding / Q000187:drug effects; D012709:Serum Albumin / Q000378:metabolism*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D012709:Serum Albumin; D001663:Bilirubin; D007052:Ibuprofen