title: Pilot study of oral polymeric N-acetyl-D-glucosamine as a potential treatment for patients with osteoarthritis.
abstract: Glucosamine and its derivatives, such as glucosamine sulfate and N-acetyl-D-glucosamine (NAG), have been shown to be effective in the treatment of patients with osteoarthritis. Unfortunately, the half-life of glucosamine in the blood is relatively short; therefore, a sustained-release form of the compound would be highly desirable. The purpose of this pilot study was to determine whether the polymeric form of NAG (POLY-Nag) could provide a longer-lasting oral source of NAG. Ten healthy subjects each ingested 1 g/d of either NAG or POLY-Nag for 3 days. After a 4-day washout period, each subject was crossed over to receive the other compound for 3 days. Serum samples were collected and analyzed using high-performance liquid chromatography. Results show that orally ingested NAG and POLY-Nag are absorbed, resulting in increased serum levels of NAG, and POLY-Nag appears to be at least as effective as NAG. Serum levels of NAG had decreased by 48 hours after cessation of ingestion of NAG or POLY-Nag but were still above baseline levels. Increases in serum glucosamine levels indicate that NAG and POLY-Nag are converted to glucosamine in vivo. In conclusion, POLY-Nag may provide a source of serum glucosamine for treatment of patients with osteoarthritis. Longer and more rigorous pharmaco-kinetic and clinical studies need to be done.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of North Texas Health Science Center, Fort Worth, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Talent
authors.forename: R W
authors.initials: RW
authors.lastname: Gracy
mesh_terms: D000042:Absorption; D000117:Acetylglucosamine / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000284:Administration, Oral; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D018592:Cross-Over Studies; D005260:Female; D005500:Follow-Up Studies; D005944:Glucosamine / Q000493:pharmacokinetics / Q000627:therapeutic use; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000097:blood / Q000188:drug therapy*; D010865:Pilot Projects; D011108:Polymers / Q000493:pharmacokinetics / Q000627:therapeutic use; D012016:Reference Values; D016896:Treatment Outcome
chemical_list: D011108:Polymers; D005944:Glucosamine; D000117:Acetylglucosamine