title: [Diagnosis, clinical aspects and therapy of early chromoblastomycosis in a case example].
abstract: Despite the availability of modern antimycotics, which produce high cure rates in early infections, the therapy of advanced chromoblastomycosis is still unsatisfactory. An initial chromoblastomycosis caused by a hitherto unidentified species of the genus Phialophora was diagnosed in a 46-year-old teacher. The organism was isolated twice at an interval of 6 weeks from a partly psoriasiform, partly verrucous lesion on the 4th toe. The infection was apparently acquired 4 years ago during a holiday at Cape Verde. Treatment with itraconazole (Sempera). 200 mg/day, and amphotericin B (Ampho-Moronal) cream for 6 weeks initially resulted in rapid regression. However, 4 weeks after cessation of therapy, the Phialophora species was cultured again from skin scrapings. Complete healing was achieved after re-treatment with itraconazole for 20 weeks at the same dosage in combination with topical amorolfine and local hyperthermia. Until now, no relapse has occurred. The present case demonstrates that this rare disease, which mainly occurs as a traumatic mycosis in the rural population of tropical regions, must be included in the differential diagnosis of psoriasiform or verrucous skin lesions and also included in the list of diseases which may be acquired while on vacation in exotic locations.
authors.affiliation: Zentrum für Dermatologie und Andrologie, Justus-Liebig-Universität, Giessen.
authors.forename: P
authors.initials: P
authors.lastname: Mayser
authors.forename: K
authors.initials: K
authors.lastname: Gründer
authors.forename: S
authors.initials: S
authors.lastname: Qadripur
authors.forename: F M
authors.initials: FM
authors.lastname: Köhn
authors.forename: W B
authors.initials: WB
authors.lastname: Schill
authors.forename: G S
authors.initials: GS
authors.lastname: de Hoog
mesh_terms: D000287:Administration, Topical; D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D002862:Chromoblastomycosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005533:Foot Dermatoses / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D010676:Phialophora / Q000187:drug effects / Q000302:isolation & purification / Q000648:ultrastructure; D012008:Recurrence
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B