Can recombinant human growth hormone (rhGH) improve the adequacy of dialysis (KT/V)?
Dialysis adequacy as estimated by urea kinetics could lead to false interpretations, especially if the dialysed patient has a high growth velocity and a stimulated protein anabolic state as is expected during rhGH treatment. Assumptions made from comparison of the UKM parameters such as PCRn, KT/V and TACurea, which all derive from the same urea appearance, are particularly risky. Dialysis adequacy appreciation during rhGH treatment needs, at least, knowledge of urea kinetic and dietary intake, and these should not be calculated from the same parameters.
Fischbach
M
M
Nephrology Dialysis Transplantation Children's Unit, Strasbourg, France.
D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy* / Q000628:therapy; D011506:Proteins / Q000378:metabolism; D006435:Renal Dialysis; D016896:Treatment Outcome; D014508:Urea / Q000097:blood
D011506:Proteins; D019382:Human Growth Hormone; D014508:Urea