title: Unfavorable effect of smoking on the elastic properties of the human aorta.
abstract: BACKGROUND
  Smoking is a major risk factor for cardiovascular morbidity and mortality. Because previous studies have shown that smoking affects vasomotor response, we hypothesized that smoking may also acutely alter aortic elastic properties.
  
  
  RESULTS
  We studied 40 male current and long-term smokers who underwent diagnostic cardiac catheterization for chest-pain evaluation. Twenty subjects (age, 48 +/- 2 years, mean +/- SEM) were randomly assigned to smoking and 20 (age, 47 +/- 2 years) to sham smoking studies. Aortic elastic properties were studied with the determination of the aortic pressure-diameter relation before smoking, every minute for the first 5 minutes after the initiation of smoking or sham smoking, and every 5 minutes for the following 15 minutes. Instantaneous diameter of the thoracic aorta was measured with a special ultrasonic dimension catheter developed in our laboratory and previously validated. Instantaneous aortic pressure was measured at the same site as was diameter with a Millar micromanometer. Smoking was associated with significant changes in the aortic pressure-diameter relation that denote deterioration of the elastic properties and were maintained during the whole study period: the slope of the pressure-diameter loop became steeper (baseline, 35.43 +/- 1.38; minute 1, 45.26 +/- 1.65; peak at minute 10, 46.36 +/- 1.69 mm Hg/mm; P < .001) and aortic distensibility decreased (baseline, 2.08 +/- 0.12; minute 1, 1.60 +/- 0.08; nadir at minute 5, 1.54 +/- 0.07 x 10(-6) cm2.dyne-1; P < .001). In contrast, no changes in aortic elasticity indexes were observed with sham smoking.
  
  
  CONCLUSIONS
  Smoking is associated with an acute deterioration of aortic elastic properties. This effect of smoking may contribute to the unfavorable consequences of smoking on the cardiovascular system.
authors.affiliation: Department of Cardiology, Hippokration Hospital, University of Athens, Greece.
authors.forename: C
authors.initials: C
authors.lastname: Stefanadis
authors.forename: E
authors.initials: E
authors.lastname: Tsiamis
authors.forename: C
authors.initials: C
authors.lastname: Vlachopoulos
authors.forename: C
authors.initials: C
authors.lastname: Stratos
authors.forename: K
authors.initials: K
authors.lastname: Toutouzas
authors.forename: C
authors.initials: C
authors.lastname: Pitsavos
authors.forename: S
authors.initials: S
authors.lastname: Marakas
authors.forename: H
authors.initials: H
authors.lastname: Boudoulas
authors.forename: P
authors.initials: P
authors.lastname: Toutouzas
mesh_terms: D001013:Aorta, Thoracic / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D004548:Elasticity / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000494:pharmacology; D012907:Smoking / Q000009:adverse effects* / Q000503:physiopathology
chemical_list: D009538:Nicotine