Characterization of cortical spreading depression by imaging of intrinsic optical signals.
The spatiotemporal progression of cortical spreading depression was investigated by imaging of activity-dependent intrinsic optical signals in rat sensorimotor cortex. In contrast to the traditional conception of a uniformly propagating event, the evolution of the spreading depression was characterized by an asymmetrical propagating wavefront and a non-uniform dispersion of optical signals behind the wavefront. As these optical signals are a reflection of underlying molecular and metabolic processes, the imaging approach to spreading depression might constitute a useful technique for investigating the functional organization as well the pathophysiology of the cerebral cortex.
Yoon
R S
RS
Department of Physiology, University of Toronto, Ontario, Canada.
Tsang
P W
PW
Lenz
F A
FA
Kwan
H C
HC
D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D007091:Image Processing, Computer-Assisted; D008297:Male; D008564:Membrane Potentials / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar