[Synthesis and study of immobilized insulin].
Conjugates of insulin with duck egg-white ovomucoid and soybean trypsin inhibitor were synthesized. The conjugates are highly stable to alpha-chymotrypsin treatment. Oral administration of insulin-ovomucoid conjugates in rabbits significantly lowered blood glucose level unlike administration of insulin-soybean trypsin conjugate.
Valuev
I L
IL
Valuev
L I
LI
Sytov
G A
GA
Platé
N A
NA
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004372:Ducks; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D007328:Insulin / Q000138:chemical synthesis* / Q000494:pharmacology; D009961:Orosomucoid / Q000494:pharmacology*; D011817:Rabbits; D014360:Trypsin Inhibitor, Kunitz Soybean / Q000494:pharmacology*
D001786:Blood Glucose; D004791:Enzyme Inhibitors; D007328:Insulin; D009961:Orosomucoid; D014360:Trypsin Inhibitor, Kunitz Soybean