title: UFT modulated with leucovorin in advanced colorectal cancer: Oncopaz experience.
abstract: A phase II trial of UFT (Tegafur and Uracil) modulated by leucovorin was undertaken by the Oncopaz Cooperative Group to assess the efficacy and toxicity of this combination in patients with advanced colorectal cancer. A total of 75 patients were given 500 mg/m2 intravenous leucovorin and 195 mg/m2 of oral UFT on day 1, followed by oral leucovorin 15 mg/12 h and 195 mg/m2/12 h of oral UFT on days 2-14. An overall response rate of 39% was obtained, with seven complete responses (9%), and 22 partial responses (29%). The primary toxicity was gastrointestinal, with grade 1-2 diarrhea occurring in 8.5% of courses, and grade 3-4 in 3.5%. Hematologic toxicity was minimal, and there were no deaths due to toxicity. This regimen was active and well tolerated in patients with advanced colorectal cancer, including those 70 years of age or older.
authors.affiliation: Hospital General La Paz, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: González Barón
authors.forename: J
authors.initials: J
authors.lastname: Feliu
authors.forename: C
authors.initials: C
authors.lastname: Garcia Girón
authors.forename: J
authors.initials: J
authors.lastname: Espinosa
authors.forename: B
authors.initials: B
authors.lastname: Martinez
authors.forename: E
authors.initials: E
authors.lastname: Blanco
authors.forename: M C
authors.initials: MC
authors.lastname: Crespo
authors.forename: A
authors.initials: A
authors.lastname: Ordóñez
authors.forename: E
authors.initials: E
authors.lastname: Espinosa
authors.forename: J
authors.initials: J
authors.lastname: de Castro
authors.forename: F
authors.initials: F
authors.lastname: Juárez
authors.forename: A
authors.initials: A
authors.lastname: Colmenarejo
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D004338:Drug Combinations; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage* / Q000009:adverse effects; D005641:Tegafur / Q000008:administration & dosage* / Q000009:adverse effects; D014498:Uracil / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D004338:Drug Combinations; C096910:UFT(R) drug; D005641:Tegafur; D014498:Uracil; D002955:Leucovorin