Treatment with bifemelane for optic nerve damage following high intraocular pressure in rat eyes.
This study found that pretreatment with 4-(o-benzylphenoxy)-N- methylbuty-lamine hydrochloride (bifemelane hydrochloride, Celeport) reduced ischemia-reperfusion injury in rat eyes. Bifemelane (25 mg/kg) was injected intraperitoneally 30 minutes before an ischemic insult, then acute ischemia of the retina and optic disc was induced by increasing intraocular pressure to 110 mmHg for 45 minutes. After one week, the axonal count of the optic nerve was investigated using electron microscopy. The control group consisted of vehicle-treated eyes which received normal saline. The axon count was 93.4 +/- 7.9 for the bifemelane treated group, and 79.2 +/- 6.4 for the controls. The axon count in the treated group was significantly higher. These results suggest that bifemelane, which prevents cerebral nerve cell damage from ischemia, can reduce ischemic retinal nerve cell injury.
Adachi
M
M
Department of Ophthalmology, Kansai Medical University, Osaka, Japan.
Takahashi
K
K
Yuge
K
K
Nishikawa
M
M
Miki
H
H
Uyama
M
M
D000818:Animals; D001369:Axons / Q000648:ultrastructure; D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D002452:Cell Count; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D007429:Intraocular Pressure; D007511:Ischemia / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D008297:Male; D009798:Ocular Hypertension / Q000150:complications*; D009898:Optic Disk / Q000098:blood supply / Q000473:pathology; D009900:Optic Nerve / Q000098:blood supply / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D012171:Retinal Vessels / Q000187:drug effects / Q000473:pathology
D001559:Benzhydryl Compounds; D016166:Free Radical Scavengers; C031906:bifemelane