Plasma tumor necrosis factor-a (TNF-a) levels in Gaucher disease.
Tumor necrosis factor-a (TNF-a) levels were measured in the plasma of patients with different types of Gaucher disease (GD) and patients with other lysosomal storage diseases. The highest TNF-a levels were observed in the most severe neuronopathic type of GD, exceeding those found in healthy individuals as well as patients with other lysosomal disorders. Type I GD cases showed a wide range of TNF-a levels ranging from normal to 2.5 x the highest control value. TNF-a is a pleiotropic cytokine produced mainly by activated macrophages. Our data suggest that it may play a role in the pathophysiology of GD disease.
Michelakakis
H
H
Department of Enzymology and Cellular Function, Ag. Sophia Children's Hospital, Athens, Greece.
Spanou
C
C
Kondyli
A
A
Dimitriou
E
E
Van Weely
S
S
Hollak
C E
CE
Van Oers
M H
MH
Aerts
J M
JM
D005776:Gaucher Disease / Q000097:blood*; D006596:Hexosaminidases / Q000097:blood; D006801:Humans; D008361:Mannosidases / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D043323:alpha-Mannosidase; D001619:beta-N-Acetylhexosaminidases / Q000097:blood
D014409:Tumor Necrosis Factor-alpha; D006596:Hexosaminidases; D008361:Mannosidases; C086400:chitotriosidase; D043323:alpha-Mannosidase; D001619:beta-N-Acetylhexosaminidases