Isosorbide nitrates, nitroglycerin, and sodium nitroprusside induce vasodilation concomitantly with inhibition of carbonic anhydrase I in erythrocytes.
This study describes the relationship between nitroglycerin, isosorbide dinitrate, sodium nitroprusside, and carbonic anhydrase I, as well as the involvement of this carbonic anhydrase I in vasodilation. Two groups of coronary patients and a group of rabbits underwent treatment with the above-mentioned vasodilating drugs. The activity of red blood cell carbonic anhydrase was monitored and determined by the stopped-flow method. The results show that these drugs inhibit the activity of the isozyme in parallel to their vasodilating effect. The results of this study lead to the hypothesis that through the pH modifications induced by these vasodilators by the inhibition of carbonic anhydrase I, the isozyme may be involved in the regulation of vascular tonus.
Puscas
I
I
Center for Medical Research and Assistance, Simleu Silvaniei, Salaj, Romania.
Vlaicu
R
R
Lazar
A
A
D000818:Animals; D002257:Carbonic Anhydrase Inhibitors / Q000008:administration & dosage*; D002256:Carbonic Anhydrases / Q000096:biosynthesis*; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D003331:Coronary Vessels / Q000187:drug effects* / Q000503:physiopathology; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D009566:Nitrates / Q000008:administration & dosage*; D005996:Nitroglycerin / Q000008:administration & dosage*; D009599:Nitroprusside / Q000008:administration & dosage*; D011817:Rabbits; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage*
D002257:Carbonic Anhydrase Inhibitors; D009566:Nitrates; D014665:Vasodilator Agents; D009599:Nitroprusside; D002256:Carbonic Anhydrases; D005996:Nitroglycerin