Synthesis of norbiotinamine and its derivatives.
Synthesis of norbiotinamine (II) and its reactive derivatives, isothiocyanates (III and IV), iodoacetamide (V), and maleimide (VI), are described. In addition, N-norbiotinyl-gamma-L-glutamylamide (VII) was prepared as a potential alternative to the fixable polar tracer biocytin (biotinoyllysine).
Szalecki
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Molecular Probes, Inc., Eugene, Oregon 97402, USA.
D001360:Avidin / Q000737:chemistry; D001710:Biotin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D005971:Glutamates / Q000138:chemical synthesis / Q000737:chemistry; D007460:Iodoacetamide / Q000031:analogs & derivatives / Q000138:chemical synthesis; D017879:Isothiocyanates / Q000138:chemical synthesis; D008239:Lysine / Q000031:analogs & derivatives / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
D005971:Glutamates; D017879:Isothiocyanates; C102607:norbiotinyl-gamma-glutamylamide; C102608:norbiotinylamine; D001360:Avidin; D001710:Biotin; C013411:biocytin; D008239:Lysine; D007460:Iodoacetamide