3,6-Disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles: synthesis, antimicrobial and antiviral activity. II.
A series of novel 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4] thiadiazole derivatives was prepared and tested to evaluate their antimycotic and antibacterial activities. Anti-HIV-1 activity has also been investigated. Among the test compounds, derivatives 10a-14a and 16c showed anti-HIV-1 activity at concentrations slightly below those cytotoxic. Substitutions at 3 and 6 positions seems to be important in lowering the cytotoxicity of compounds.
Invidiata
F P
FP
Istituto Farmacochimico dell'Università di Palermo, Italy.
Simoni
D
D
Scintu
F
F
Pinna
N
N
D000900:Anti-Bacterial Agents; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D012475:Salmonella / Q000187:drug effects; D012760:Shigella / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects; D013830:Thiadiazoles / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D019380:Anti-HIV Agents; D000890:Anti-Infective Agents; D013830:Thiadiazoles