[The role of natural growth stimulators in regulation of regeneration processes in small intestinal epithelium after irradiation].
In this paper, basing on recently published data, the influence of growth factors on small intestine epithelium regeneration after irradiation is presented. Our knowledge of growth control in the small intestine mucosa may become an accepted mode of radio-, chemotherapy and the treatment of acute radiation sickness in the future. Results of recent studies suggest that there are different factors which can modulate the process of epithelium regeneration. Some of them such as gastrin, enteroglucagon, CCK, EGF, FGF, TGF and IL-11 are able to enhance this process. In addition, other factor-PGE-2 is responsible for not only stimulation of small intestine epithelium growth but radioprotection as well.
Dziekiewicz
M
M
Zakładu Radiobiologii Wojskowego, Instytutu Higieny i Epidemiologii, im. Gen. Karola Kaczkowskiego, w Warszawie.
D015232:Dinoprostone / Q000502:physiology; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D007413:Intestinal Mucosa / Q000502:physiology*; D007421:Intestine, Small / Q000502:physiology*; D011832:Radiation Injuries / Q000503:physiopathology*; D012038:Regeneration / Q000502:physiology*
D006133:Growth Substances; D015232:Dinoprostone