Is rhGH anabolic in patients undergoing peritoneal dialysis?
The effect of rhGH treatment on protein metabolism was studied in nine prepubertal patients on CAPD. An improvement in nitrogen balance as evidenced by a falling of blood urea nitrogen and urea nitrogen appearance with a constant protein intake was noticed. The significant increase in serum creatinine and creatinine excretion with a constant weekly creatinine clearance and the increase in mid-arm muscle circumference were all indications of an improvement in lean body mass. In addition, there was an improvement in the pattern of plasma amino acids and an increase in serum albumin, possibly as a result of the improvement of protein metabolism.
Stefanidis
C J
CJ
A Kyriakou Children's Hospital, Athens, Greece.
D000596:Amino Acids / Q000097:blood; D001806:Blood Urea Nitrogen; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D006128:Growth / Q000187:drug effects; D019382:Human Growth Hormone / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000378:metabolism*; D009752:Nutritional Status / Q000187:drug effects*; D010531:Peritoneal Dialysis, Continuous Ambulatory; D011506:Proteins / Q000378:metabolism*
D000596:Amino Acids; D011506:Proteins; D019382:Human Growth Hormone; D003404:Creatinine