title: Correlation of seroreactivity with response to antibiotics in pediatric Lyme borreliosis.
abstract: Response to treatment with antibiotics was compared with serologic reactivity and clinical symptoms in a pediatric population with presumptive diagnoses of Lyme borreliosis. The population analyzed for this study consisted of a subset of a larger Lyme clinic population being monitored as part of a prospective study on pediatric Lyme borreliosis. All patients resided in an area in which Ixodes scapularis and Borrelia burgdorferi are considered endemic. Serum from patients was tested by enzyme-linked immunosorbent assay and Western blotting. Response to antibiotics was evaluated by members of a pediatric Lyme clinic. Results showed that positive serologic test results correlate with a favorable response to antibiotics, as does the presence of erythema migrans (EM), regardless of serologic status. Seronegative patients without EM had chronic fatigue and arthralgia and/or myalgia as primary symptoms and did not respond to antibiotics, even when multiple courses of treatment were given. These results indicate that serologic tests designed to have high specificity can reliably rule out Lyme borreliosis in patients with chronic symptoms, thus preventing unnecessary treatment with antibiotics.
authors.affiliation: Department of Clinical Science, Alfred I. duPont Institute, Wilmington, Delaware 19899, USA.
authors.forename: P T
authors.initials: PT
authors.lastname: Fawcett
authors.forename: C D
authors.initials: CD
authors.lastname: Rosé
authors.forename: K M
authors.initials: KM
authors.lastname: Gibney
authors.forename: R A
authors.initials: RA
authors.lastname: Doughty
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000032:analysis; D015748:Borrelia burgdorferi Group / Q000276:immunology*; D002648:Child; D004352:Drug Resistance, Microbial / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D015151:Immunoblotting; D008193:Lyme Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology*
chemical_list: D000900:Anti-Bacterial Agents; D015415:Biomarkers