title: Mouse U2af1-rs1 is a neomorphic imprinted gene.
abstract: The mouse U2af1-rs1 gene is an endogenous imprinted gene on the proximal region of chromosome 11. This gene is transcribed exclusively from the unmethylated paternal allele, while the methylated maternal allele is silent. An analysis of genome structure of this gene revealed that the whole gene is located in an intron of the Murr1 gene. Although none of the three human U2af1-related genes have been mapped to chromosome 2, the human homolog of Murr1 is assigned to chromosome 2. The mouse Murr1 gene is transcribed biallelically, and therefore it is not imprinted in neonatal mice. Allele-specific methylation is limited to a region around U2af1-rs1 in an intron of Murr1. These results suggest that in chromosomal homology and genomic imprinting, the U2af1-rs1 gene is distinct from the genome region surrounding it. We have proposed the neomorphic origin of the U2af1-rs1 gene by retrotransposition and the particular mechanism of genomic imprinting of ectopic genes.
authors.affiliation: Department of Bioscience, National Cardiovascular Center Research Institute, Suita, Osaka, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Nabetani
authors.forename: I
authors.initials: I
authors.lastname: Hatada
authors.forename: H
authors.initials: H
authors.lastname: Morisaki
authors.forename: M
authors.initials: M
authors.lastname: Oshimura
authors.forename: T
authors.initials: T
authors.lastname: Mukai
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D000831:Animals, Newborn; D001483:Base Sequence; D002352:Carrier Proteins; D002874:Chromosome Mapping; D019175:DNA Methylation; D005260:Female; D005796:Genes / Q000235:genetics; D018392:Genomic Imprinting / Q000235:genetics*; D006801:Humans; D007438:Introns / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D011506:Proteins / Q000235:genetics*; D015183:Restriction Mapping; D018626:Retroelements; D012261:Ribonucleoproteins; D012689:Sequence Homology, Nucleic Acid; D000072668:Splicing Factor U2AF
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C480519:COMMD1 protein, human; D002352:Carrier Proteins; C103799:Commd1 protein, mouse; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D011506:Proteins; D018626:Retroelements; D012261:Ribonucleoproteins; D000072668:Splicing Factor U2AF; C098232:ZRSR2P1 protein, human; C000607495:Zrsr1 protein, mouse