Intracellular factor XIII: cellular distribution of factor XIII subunit a in humans.
In addition to the plasma where factor XIII subunit A is present as part of the heterodimers of the tetrameric fibrin-stabilizing factor, homodimers of factor XIII A can also be detected in cellular localization in different human tissues. Experimental findings verified that these cells belong to the megakaryocyte/ platelet and the monocyte/macrophage cell lines. Additionally, factor XIII A is present in hepatocytes localized mainly around central veins in the liver and occasionally expressed in certain malignantly transformed cells. It is reasonable to suppose that factor XIII A acts not only as a member of the clotting cascade, but also as a cellular enzyme that can catalyze molecular interactions intracellularly (during the assembly/reassembly of the cytoskeleton) or extracellularly (in the connective tissue matrix around the cells containing it).
Adány
R
R
Department of Hygiene and Epidemiology, University School of Medicine, Debrecen, Hungary.
D001792:Blood Platelets / Q000737:chemistry; D019070:Cell Lineage; D005176:Factor XIII / Q000032:analysis* / Q000737:chemistry; D005326:Fetal Proteins / Q000032:analysis; D006801:Humans; D008099:Liver / Q000737:chemistry / Q000166:cytology; D008264:Macrophages / Q000737:chemistry; D008533:Megakaryocytes / Q000737:chemistry; D009000:Monocytes / Q000737:chemistry; D009363:Neoplasm Proteins / Q000032:analysis; D009369:Neoplasms / Q000737:chemistry; D009928:Organ Specificity; D013347:Subcellular Fractions / Q000737:chemistry*
D005326:Fetal Proteins; D009363:Neoplasm Proteins; D005176:Factor XIII