Constituents of Veltheimia viridifolia; I. Homoisoflavanones of the bulbs.
The new homoisoflavanone R(-)-3-(4-hydroxybenzyl)-5-hydroxy-6, 7,8-trimethoxychroman-4-one (1) was isolated from the petroleum ether and the diethyl ether extracts of the bulbs of Veltheimia viridifolia (Hyacinthaceae) together with the known homoisoflavanone muscomin (2). The structures of the compounds were elucidated by means of 1H-NMR, 2D 1H-1H-COSY, 13C-NMR, HMQC, HMBC, mass, and CD spectra. Pharmacological testings of the new homoisoflavanone are reported.
Amschler
G
G
Lehrstuhl für Pharmazeutische Chemie, Universität Freiburg, Germany.
Frahm
A W
AW
Hatzelmann
A
A
Kilian
U
U
Müller-Doblies
D
D
Müller-Doblies
U
U
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001993:Bronchodilator Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002417:Cattle; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D015289:Leukotrienes / Q000096:biosynthesis; D015394:Molecular Structure; D010726:Phosphodiesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010944:Plants / Q000737:chemistry*; D013019:South Africa
C103704:3-(4-hydroxybenzyl)-5-hydroxy-6,7,8-trimethoxychroman-4-one; D000975:Antioxidants; D001993:Bronchodilator Agents; D007529:Isoflavones; D015289:Leukotrienes; D010726:Phosphodiesterase Inhibitors; C103700:muscomin