title: Feto-maternal outcome in pre-eclampsia/eclampsia with and without multisystem organ failure managed by strict input/output fluid regimen.
abstract: To determine whether peripartum homeostasis can be maintained without invasive vascular monitoring, comparison of biological parameters in severe preeclampsia (PE)/eclampsia(E) with and without multisystem organ failure (MSOF) was done. Twenty six cases of severe PE/E with (n = 13) and without (n = 13) MSOF were managed with a strict input/output fluid regimen. Day one pre- and day one postdelivery haematology and blood chemistry were performed. MSOF was characterised by self-limiting hepato-renal failure and thrombocytopenia. Foetal demise was higher with MSOF (53.8%) than without (38.5%), but not significantly (chi-square = 0.62). Abruptio placentae was significantly more prevalent without (30.8%) than with MSOF (7.7%; chi-square = 5.54). Eclamptic seizures occurred at the same rate (46.2 and 30.8%; chi-square = 0.65) with both conditions. There was no maternal death. Without invasive vascular monitoring peripartum homeostasis can be achieved in severe PE/E with or without MSOF through a strict input/output regimen using Ringer's lactate.
authors.affiliation: Department of Obstetrics and Gynaecology, Unitra, Transkei, South Africa.
authors.forename: L J
authors.initials: LJ
authors.lastname: Van Bogaert
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004461:Eclampsia / Q000097:blood / Q000150:complications* / Q000628:therapy*; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D006801:Humans; D007552:Isotonic Solutions / Q000627:therapeutic use; D009102:Multiple Organ Failure / Q000209:etiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D000077325:Ringer's Lactate; D016896:Treatment Outcome; D014882:Water-Electrolyte Balance
chemical_list: D007552:Isotonic Solutions; D000077325:Ringer's Lactate