Neuroautoimmunity: pathogenic implications for Alzheimer's disease.
Immune factors such as cellular immunity, autoimmunity, and inflammation may play a pathogenic role in Alzheimer's disease (AD), a neurodegenerative disorder. Based on immunologic dysregulation in many patients, a neuroautoimmunity (NAI) model is proposed which suggested a CD8+ cell-mediated mechanism (activated cytotoxic T lymphocytes); CD4+ suppressor/inducer (2H4+) cells may also be involved. Antibrain antibodies may contribute through a cell-specific autoimmune assault leading to neurodegeneration of the AD type. Thus, a cell-mediated autoimmune response against brain antigens may explain the immune subset of AD.
Singh
V K
VK
School of Medicine, University of Michigan, Ann Arbor 48109, USA.
D000544:Alzheimer Disease / Q000209:etiology* / Q000276:immunology* / Q000473:pathology; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006801:Humans; D009474:Neurons / Q000276:immunology / Q000473:pathology