title: G protein-coupled receptors: heterologous regulation of homologous desensitization and its implications.
abstract: Two patterns of rapid desensitization have been characterized for G protein-coupled receptors: homologous desensitization, which mainly involves G protein-coupled receptor kinases and arrestins, and heterologous desensitization, which mainly involves protein kinases A (PKA) and C (PKC). In this review, Tsu Tshen Chuang and colleagues discuss evidence to show that PKA and PKC can modify the functional state of the G protein-coupled receptor kinases/arrestin homologous desensitization machinery, providing a novel level of cross-talk in signal transduction. Studies on regulation of G protein-coupled receptor kinases and arrestins confirm that the functional state of this machinery may have important consequences for cellular responsiveness and may represent new targets for therapeutic strategies.
authors.affiliation: Receptor Systems Unit, GlaxoWellcome Research and Development, Stevenage, UK.
authors.forename: T T
authors.initials: TT
authors.lastname: Chuang
authors.forename: L
authors.initials: L
authors.lastname: Iacovelli
authors.forename: M
authors.initials: M
authors.lastname: Sallese
authors.forename: A
authors.initials: A
authors.lastname: De Blasi
mesh_terms: D000818:Animals; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D010766:Phosphorylation; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012680:Sensitivity and Specificity
chemical_list: D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins