Apomorphine-induced suppression of prey oriented turning in toads is correlated with activity changes in pretectum and tectum: [14C]2DG studies and single cell recordings.
In common toads, after systemic administration of the dopamine agonist apomorphine (APO), prey-oriented turning was suppressed. Searching for neural correlates, the present study shows APO-induced increases in glucose utilization in the retinorecipient pretectum and dorsal optic tectum and a decrease in the medial tectal output layers. This pattern of metabolic activity is resembled by neuronal discharge activities recorded in response to a prey stimulus; the discharge rates are increased in retinal ganglion cells and pretectal neurons and decreased in tectal output neurons. We suggest that an APO-induced enhancement of pretecto-tectal inhibitory influences contributes to the reduction of tectal output, thus suppressing prey-oriented turning behavior.
Glagow
M
M
Abteilung Neurobiologie, Fachbereich Biologie/Chemie, Universität Kassel (GhK), Germany.
Ewert
J P
JP
D000818:Animals; D000963:Antimetabolites; D001058:Apomorphine / Q000494:pharmacology*; D002023:Bufo bufo; D003847:Deoxyglucose; D018491:Dopamine Agonists / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011235:Predatory Behavior / Q000187:drug effects*; D013477:Superior Colliculi / Q000166:cytology / Q000187:drug effects / Q000502:physiology*
D000963:Antimetabolites; D018491:Dopamine Agonists; D003847:Deoxyglucose; D005947:Glucose; D001058:Apomorphine