title: Food intake is inversely correlated with central nervous system histamine receptor (H1) concentrations in male Sprague-Dawley rats fed normal, low protein, low energy or poor quality protein diets.
abstract: The reported studies were designed to examine relationships between whole-brain histamine receptors (H1) and food intake in male Sprague-Dawley rats. Three different experiments were conducted. In each experiment, control rats were fed normal protein (25 g casein/100 g food) and normal metabolizable energy (16.21 kJ/100 g food) diets. Feeding low protein diets (1 g casein/100 g food) elevated central H1 receptor concentrations (P < 0.0027) and reduced voluntary food intake (P < 0.007) compared with normal diets. Feeding low energy diets lowered H1 receptor concentrations (P < 0.0089) and increased voluntary food intake (P < 0.0012). Low quality protein diets also affected the central nervous histaminergic system. Whole-brain H1 receptor concentrations were significantly higher for rats fed low quality protein (25 g gelatin/100 g food) compared with rats fed casein (P < 0.0001). Rats fed medium quality protein (25 g wheat gluten/100 g food) or low quality protein ate significantly less food (P < 0.0001). In all experiments, dietary manipulation affected central histamine receptors. Elevated concentrations of H1 receptors were associated with a decrease in food intake whereas lowered concentrations of H1 receptors were associated with an increase in food intake (P < 0.001). The results of these experiments support the hypothesis that central histamine H1 receptor concentrations in male rats are inversely correlated with voluntary food intake and affected by dietary composition.
authors.affiliation: Department of Nutrition and Food Science, University of Kentucky, Lexington 40506-0054, USA.
authors.forename: A U
authors.initials: AU
authors.lastname: Haq
authors.forename: H M
authors.initials: HM
authors.lastname: Bundrant
authors.forename: L P
authors.initials: LP
authors.lastname: Mercer
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011969:Receptors, Histamine H1 / Q000187:drug effects*
chemical_list: D004044:Dietary Proteins; D011969:Receptors, Histamine H1