title: Detection and measurement of inflammatory cytokines in implant crevicular fluid: a pilot study.
abstract: Peri-implantitis has been shown to possess clinical characteristics similar to those of periodontitis. This pilot study was conducted to determine levels of inflammatory cytokines in crevicular fluid from healthy implants and those implants affected by peri-implantitis. Fifty implants from 13 patients were examined. A clinical examination was performed, and gingival crevicular fluid samples were collected and analyzed for cytokines. Implants were categorized clinically as healthy, early peri-implantitis, or advanced peri-implantitis. Interleukin-1 beta was detected in the crevicular fluid of implants in all three groups (healthy = 59.47 +/- 15.55 pg/site; early peri-implantitis = 460.77 +/- 35.67 pg/site; and advanced peri-implantitis = 191.10 +/- 21.60 pg/site [mean +/- SEM]). These results indicate that interleukin-1 beta is present in implant gingival crevicular fluid and may be modulating attachment loss in implants suffering from peri-implantitis. Thus, interleukin-1 beta may be used to monitor disease progression.
authors.affiliation: Department of Prosthodontics and Biomaterials, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark 07013, USA.
authors.forename: F S
authors.initials: FS
authors.lastname: Panagakos
authors.forename: H
authors.initials: H
authors.lastname: Aboyoussef
authors.forename: R
authors.initials: R
authors.lastname: Dondero
authors.forename: J J
authors.initials: JJ
authors.lastname: Jandinski
mesh_terms: D016301:Alveolar Bone Loss / Q000276:immunology / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis; D016207:Cytokines / Q000032:analysis*; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D017267:Dental Prosthesis Design; D019094:Dental Prosthesis, Implant-Supported; D018450:Disease Progression; D005500:Follow-Up Studies; D005883:Gingival Crevicular Fluid / Q000737:chemistry* / Q000276:immunology; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis; D017622:Periodontal Attachment Loss / Q000276:immunology / Q000378:metabolism; D010518:Periodontitis / Q000276:immunology / Q000378:metabolism; D010865:Pilot Projects; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D015415:Biomarkers; D016207:Cytokines; D015921:Dental Implants; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha