[Pathohistologic and ultrastructural features of drug-induced membranous glomerulonephritis].
Nephrobiopsies of 20 patients with drug-induced membranous glomerulonephritis were studied. Renal injury was produced by diuretics (7 patients), gold salts (6), penicillamine (4), captopril (3). Drug-induced membranous glomerulonephritis in contrast to idiopathic one ran a benign course after proper therapy based on discontinuation of the drug. Main pathomorphological features of secondary membranous glomerulonephritis that help to differentiate it from the primary one were established: absence of total injury of the glomeruli, hypercellularity of the damaged glomeruli, pathomorphological changes only of the part of the capillary loops, presence of both subepithelial and mesangial deposits.
Pospishil'
Iu A
IuA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002196:Capillaries / Q000187:drug effects / Q000473:pathology; D002216:Captopril / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004232:Diuretics / Q000009:adverse effects*; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology / Q000473:pathology*; D015433:Glomerulonephritis, Membranous / Q000139:chemically induced / Q000473:pathology*; D006046:Gold / Q000009:adverse effects*; D006801:Humans; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000009:adverse effects*
D004232:Diuretics; D006046:Gold; D002216:Captopril; D010396:Penicillamine