[Serum lactate-dehydrogenase isoenzymes in HIV positive children. A longitudinal study].
The impairment of humoral immunity with rapid turn-over of cellular B clones in children with HIV infection is known as well as the conduct of LDH isoenzymes in B cell lymphoproliferative diseases like Burkitt's lymphoma. Therefore, serum lactate-dehydrogenase activity (LD, EC 1.1.1.27) and its isoenzymes have been evaluated twice (within 12 months) in 11 children with HIV infection with respect to a control group (30 subjects). Furthermore, the relationship between those and other clinical and immunologic parameters (total lymphocytes, CD4/CD8, immunoglobulins, classification according to the Atlanta CDC 1987) has been studied. HIV infected children have shown a significant decrease in LD1 rates, which was directly correlated to CD4/CD8 values. After the follow-up, this correlation became even more significant. Thus, these findings may suggest the usefulness of LDH isoenzymes evaluation as a marker of disease activity in children with HIV infection.
Pifferi
M
M
Istituto di Clinica Pediatrica, Università degli Studi, Pisa.
Baldini
M
M
Cappuccio
A
A
Consolini
R
R
Innocenti
B
B
D000917:Antibody Formation; D016516:CD4-CD8 Ratio; D002648:Child; D002675:Child, Preschool; D004587:Electrophoresis, Agar Gel; D005260:Female; D006679:HIV Seropositivity; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000097:blood; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male
D007136:Immunoglobulins; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase