[The latest achievements of radiation cytogenetics in connection with the discovery of the method for the fluorescence hybridization in situ of the metaphase chromosomes of man and experimental animals using DNA probes (FISH)].
This review describes the development of novel promising molecular cytogenetic method--fluorescence in situ hybridization with human and animal whole-chromosome probes (F I S H). It summarizes the application of this technology in fundamental and applied fields of radiation cytogenetics and emphasizes the important role of FISH for biological dosimetry of human exposure to ionizing radiation.
Pilinskaia
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D000818:Animals; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000235:genetics* / Q000528:radiation effects; D002877:Chromosomes, Human / Q000235:genetics* / Q000528:radiation effects; D003582:Cytogenetics / Q000379:methods*; D015342:DNA Probes; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*; D008677:Metaphase / Q000528:radiation effects; D011831:Radiation Genetics / Q000379:methods*
D015342:DNA Probes