title: Primary neuroendocrine carcinoma of the skin with an unusual follicular lymphocytic infiltrate of the dermis.
abstract: Primary neuroendocrine carcinoma of the skin (PNECS) is a rare cutaneous tumor occurring predominantly on sun-exposed skin of elderly people. This histomorphological appearance of this aggressive tumor can be highly variable depending on the predominating growth pattern. We present an unusual case of PNECS: the tumor masked by a dense lymphoid infiltrate with a well-formed follicular growth pattern. In these cases of PNECS, the differential diagnosis must be extended to lymphoid neoplasms as well as lymphoepithelial neoplasms.
authors.affiliation: Department of Dermatology, University of Würzburg, Germany.
authors.forename: B C
authors.initials: BC
authors.lastname: Bastian
authors.forename: H H
authors.initials: HH
authors.lastname: Kreipe
authors.forename: E B
authors.initials: EB
authors.lastname: Bröcker
mesh_terms: D000368:Aged; D001402:B-Lymphocytes / Q000473:pathology; D018278:Carcinoma, Neuroendocrine / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D002467:Cell Nucleus / Q000648:ultrastructure; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis; D003593:Cytoplasm / Q000648:ultrastructure; D003937:Diagnosis, Differential; D005153:Facial Neoplasms / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008214:Lymphocytes / Q000473:pathology*; D008221:Lymphoid Tissue / Q000473:pathology; D016900:Neurofilament Proteins / Q000032:analysis; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*
chemical_list: D053379:Chromogranin A; D002864:Chromogranins; D016900:Neurofilament Proteins; D007633:Keratins; D010751:Phosphopyruvate Hydratase