[Impairment of myocardial perfusion reserve in microvascular angina (syndrome X): assessment by 99mTc-MIBI-SPECT].
OBJECTIVE
In 22 patients with typical chest pain and normal coronary arteries (microvascular angina, syndrome X) 99mTc-MIBI-SPECT was examined in regard to assess impairment of myocardial perfusion reserve.


METHODS
The study was performed with 99mTc-MIBI-SPECT at rest and under vasodilation with dipyridamole. The findings were compared with a normal database. A normal perfusion reserve was said to be an increase > 20% of the 99mTc-MIBI-activity.


RESULTS
In 2/22 (9%) of the patients the perfusion reserve lay > 20% i.e. 37%. In 91% of the patients a diminution or even decrease of the perfusion was to be seen. From these 9/22 (41%) of the patients showed a diminution of the 99mTc-MIBI-uptake by 6%. 1/22 patients had a decrease of the perfusion under vasodilation with dipyridamole i.e. a lower activity of 99mTc-MIBI by 13%


CONCLUSIONS
Vasodilation 99mTc-MIBI-SPECT offers good imaging quality and enables semi-quantitative assessment of myocardial perfusion reserve in patients with microvascular angina.
Langes
K
K
Abteilung für Kardiologie, Universitäts-Krankenhaus Eppendorf Hamburg, Deutschland.
Beuthien-Baumann
B
B
Lübeck
M
M
Fuchs
C
C
Schneider
M A
MA
Volk
C
C
Nienaber
C A
CA
D001794:Blood Pressure; D002637:Chest Pain; D004176:Dipyridamole; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000503:physiopathology; D006339:Heart Rate; D006801:Humans; D008297:Male; D017566:Microvascular Angina / Q000000981:diagnostic imaging*; D008875:Middle Aged; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon
D004176:Dipyridamole; D017256:Technetium Tc 99m Sestamibi