Informatics for ubiquitous sequencing.
Methods and technologies currently being developed promise an increase of between one and two orders of magnitude in the practical throughputs of DNA sequencing for gene discovery, expression analysis and variant analysis. Integrated laboratories will use all of these methods as components of a molecular strategy for the functional characterization of genes and their products. This review summarizes the types of data produced by these strategies, and the analysis and management challenges that they raise.
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National Center for Genome Resources, Santa Fe, NM 87505, USA. caf@ncgr.org
D001709:Biotechnology / Q000639:trends; D019295:Computational Biology / Q000639:trends*; D015870:Gene Expression; D030342:Genetic Diseases, Inborn / Q000175:diagnosis; D014644:Genetic Variation; D006801:Humans; D017422:Sequence Analysis, DNA / Q000639:trends*