title: Transient patterns of calbindin-D28k expression in the developing striatum of man.
abstract: In fetal and adult human brains, calbindin immunoreactivity (CB-ir) of neostriatal neuropil showed inhomogeneous pattern. A mosaic of CB-ir neuropil patches matching the acetylcholinesterase (AChE)-reactive patches and most of the encapsulated cell-dense islands was distributed in a lighter stained background matrix. During infancy, the pattern of CB expression changed from one of CB-rich patches to one of CB-poor striosomes and rich matrix. Furthermore, we observed a steady development of population of medium-sized neurons in the striatal matrix; in addition, a transient CB-expression was found in cells of the ganglionic eminence and presumably in a subset of striatal interneurons.
authors.affiliation: Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Republic of Croatia.
authors.forename: K
authors.initials: K
authors.lastname: Letinić
authors.forename: I
authors.initials: I
authors.lastname: Kostović
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000293:Adolescent; D064092:Calbindin 1; D064026:Calbindins; D002648:Child; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007231:Infant, Newborn; D017072:Neostriatum / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism*; D011247:Pregnancy; D064030:S100 Calcium Binding Protein G / Q000096:biosynthesis*
chemical_list: C576498:CALB1 protein, human; D064092:Calbindin 1; D064026:Calbindins; D064030:S100 Calcium Binding Protein G; D000110:Acetylcholinesterase