Anomalous pancreatico-biliary junction--report of a new experimental model and review of the literature.
A model of anomalous pancreatico-biliary junction was developed and used to investigate a possible role in the development of choledochal cyst and tumors of the biliary tract. An anastomosis was constructed between an isolated pancreas-duodenal segment and the gallbladder in 20 minipigs, but the results did not show any subsequent dilatation of the biliary tract, although intestinal metaplasia was observed in 20% of the animals. The severity of the epithelial changes was proportional to the duration of the experiment and may represent a premalignant change. A critical review of all reported animal models of anomalous pancreaticobiliary junction also is provided.
Benhidjeb
T
T
Department of Surgery, Hospital Charité, Humboldt-University of Berlin, Germany.
Said
S
S
Rudolph
B
B
Siegmund
E
E
D000681:Amylases / Q000378:metabolism; D000818:Animals; D001661:Biliary Tract Neoplasms / Q000209:etiology; D002758:Cholangiography; D015529:Choledochal Cyst / Q000209:etiology; D003135:Common Bile Duct / Q000002:abnormalities* / Q000473:pathology; D004195:Disease Models, Animal; D004386:Duodenum / Q000201:enzymology / Q000473:pathology; D004765:Enteropeptidase / Q000378:metabolism; D005260:Female; D005704:Gallbladder / Q000473:pathology; D008049:Lipase / Q000378:metabolism; D008297:Male; D010183:Pancreatic Ducts / Q000002:abnormalities*; D010189:Pancreatic Juice / Q000201:enzymology; D013552:Swine; D013556:Swine, Miniature
D008049:Lipase; D000681:Amylases; D004765:Enteropeptidase