Evaluation of immunogenicity and tolerance of single dose haemophilus influenzae type B (PRP-T) vaccine.
OBJECTIVE
Evaluation of immunogenicity and acceptability of PRP-T vaccine among the Indian children.


METHODS
Multicentric, open, parallel group, comparative study of Haemophilus influenzae type B vaccine, given as single (Group I) or associated (Group II) with DPT vaccine.


METHODS
Five different vaccination clinics.


METHODS
125 children between the age group of 18-24 months.


METHODS
Measurement of (i) pre and post vaccination antibody titres of Haemophilus influenze type B specific antibody; (ii) Adverse events; and (iii) Tolerance as graded by the physician.


RESULTS
Prevaccination antibody levels were > 0.15 mcg/ml in 56.3% in Group I and 35.7% in Group II. Post-seroconversion was seen in 97% in Group II receiving single and all in Group II (P > 0.05). The vaccine was well tolerated.


CONCLUSIONS
The probability of subclinical infection or cross immunity is high in India. ACTHIB vaccine has a good immunogenicity and tolerance and association with DPT does not modify the immunogenicity of ACTHIB vaccine.
Acharya
D
D
Department of Pediatrics, King Edward Memorial Hospital, Pune.
Desai
A
A
Nanavaty
N
N
Pandit
A
A
Patel
V
V
Shah
J
J
Shendurnikar
N
N
Singh
S
S
Taneja
A
A
Vani
S
S
D000942:Antigens, Bacterial / Q000097:blood*; D003906:Developing Countries; D005069:Evaluation Studies as Topic; D005260:Female; D006192:Haemophilus Infections / Q000276:immunology / Q000517:prevention & control; D018073:Haemophilus Vaccines / Q000008:administration & dosage*; D006193:Haemophilus influenzae / Q000276:immunology*; D006801:Humans; D007194:India; D007223:Infant; D008297:Male; D014611:Vaccination
D000942:Antigens, Bacterial; D018073:Haemophilus Vaccines