title: In vitro susceptibility of Helicobacter pylori to protolichesterinic acid from the lichen Cetraria islandica.
abstract: With reference to the traditional use of Cetraria islandica (Iceland moss) for relief of gastric and duodenal ulcer, plant extracts were screened for in vitro activity against Helicobacter pylori. (+)-Protolichesterinic acid, an aliphatic alpha-methylene-gamma-lactone, was identified as an active component. The MIC range of protolichesterinic acid, in free as well as salt form, was 16 to 64 micrograms/ml.
authors.affiliation: Department of Pharmacy, University of Iceland, Reykjavik, Iceland. kring@rhi.hi.is
authors.forename: K
authors.initials: K
authors.lastname: Ingolfsdottir
authors.forename: M A
authors.initials: MA
authors.lastname: Hjalmarsdottir
authors.forename: A
authors.initials: A
authors.lastname: Sigurdsson
authors.forename: G A
authors.initials: GA
authors.lastname: Gudjonsdottir
authors.forename: A
authors.initials: A
authors.lastname: Brynjolfsdottir
authors.forename: O
authors.initials: O
authors.lastname: Steingrimsson
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000494:pharmacology; D016480:Helicobacter pylori / Q000187:drug effects*; D008011:Lichens / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology
chemical_list: D010936:Plant Extracts; C095781:protolichesterinic acid; D015107:4-Butyrolactone