title: Do macrophages kill through apoptosis?
abstract: Macrophages can kill target cells independent of conventional immune specificity. Based on a re-examination of literature three decades old and recent experiments, Antonios Aliprantis and colleagues propose that macrophages kill target cells by inducing apoptosis. For this purpose, macrophages employ a selection of pro-apoptotic mediators including reactive oxygen and nitrogen species and tumour necrosis factor alpha.
authors.affiliation: Skirball Institute for Biomolecular Medicine, New York University Medical Center, Dept of Cell Biology, NY 10016, USA.
authors.forename: A O
authors.initials: AO
authors.lastname: Aliprantis
authors.forename: G
authors.initials: G
authors.lastname: Diez-Roux
authors.forename: L C
authors.initials: LC
authors.lastname: Mulder
authors.forename: A
authors.initials: A
authors.lastname: Zychlinsky
authors.forename: R A
authors.initials: RA
authors.lastname: Lang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D006801:Humans; D008264:Macrophages / Q000276:immunology*