Effect of neonatal treatment with monoclonal antibody to thyrotropin (TSH) receptor on the thyroxin (T4) level and certain parameters of the internal genital organs of adult rats.
Treatment of newborn rats with a single dose of monoclonal antibody to TSH receptor, caused permanent changes in the body weight, T4 level, and different sexual parameters. There are considerable sex and organ dependent differences in the sensitivity. Body weight and physical condition of males deteriorates, while the condition of the females is constant. However, T4 level of females significantly increases while that of the males does not change. The weight of seminal vesicle increases, while ovarian weight decreases. Effect of hCG treatment in adult age is inhibited by neonatal antibody (to TSH receptor) treatment. The experiment calls the attention to the imprinter effect of antibodies in the neonatal critical period, which effect could be manifested on the antibody's own (provoked) or foreign (related) receptor.
Karabélyos
C
C
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
Nagy
S U
SU
Csaba
G
G
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005835:Genitalia / Q000187:drug effects* / Q000254:growth & development; D006062:Gonadotropins / Q000378:metabolism / Q000494:pharmacology; D007074:Immunoglobulin G / Q000378:metabolism; D008297:Male; D010053:Ovary / Q000187:drug effects / Q000254:growth & development; D051381:Rats; D017208:Rats, Wistar; D011989:Receptors, Thyrotropin / Q000037:antagonists & inhibitors* / Q000276:immunology; D013737:Testis / Q000187:drug effects / Q000254:growth & development; D013974:Thyroxine / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D006062:Gonadotropins; D007074:Immunoglobulin G; D011989:Receptors, Thyrotropin; D013974:Thyroxine