title: The Drosophila protein Wunen repels migrating germ cells.
abstract: In Drosophila, germ cells migrate in embryonic development from the lumen of the developing gut towards the overlying mesoderm, where they enter the gonads. The gene wunen is responsible for guiding the germ cells early in this process. Here we report that the protein Wunen has two properties that allow it to use repulsion to guide the germ cells. Wunen can transform a permissive cellular environment into a repulsive one, and is expressed in the gut in a pattern that guides germ cells towards the mesoderm. Wunen shows strong similarity to the enzyme type 2 phosphatidic acid phophatase (PAP2)4, suggesting that it is involved in lipid metabolism.
authors.affiliation: The Jackson Laboratory, Bar Harbor, Maine 04609, USA.
authors.forename: N
authors.initials: N
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: K J
authors.initials: KJ
authors.lastname: Purcell
authors.forename: Y
authors.initials: Y
authors.lastname: Cheng
authors.forename: K
authors.initials: K
authors.lastname: Howard
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002465:Cell Movement / Q000502:physiology; D003001:Cloning, Molecular; D004330:Drosophila / Q000196:embryology / Q000502:physiology*; D029721:Drosophila Proteins; D005854:Germ Cells / Q000502:physiology*; D006801:Humans; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology*; D008565:Membrane Proteins; D008969:Molecular Sequence Data; D010711:Phosphatidate Phosphatase; D017386:Sequence Homology, Amino Acid
chemical_list: D029721:Drosophila Proteins; D019476:Insect Proteins; D008565:Membrane Proteins; D010711:Phosphatidate Phosphatase; C103065:wun protein, Drosophila