Acute effects of intravenous cocaine on pulmonary artery pressure and cardiac index in habitual crack smokers.
BACKGROUND
Some habitual crack cocaine smokers who deny IV drug abuse show decreased pulmonary transfer of carbon monoxide (DCO). We speculated that repeated elevations in pulmonary artery pressure (PAP) might cause pulmonary capillary damage and result in a lowered DCO, or that the reduction could be due to anoxic lung injury secondary to repeated episodes of cocaine-induced pulmonary vascular constriction.


OBJECTIVE
Compare the acute effects of i.v. cocaine HCl and placebo on PAP, cardiac stroke volume, and cardiac output estimated indirectly by continuous Doppler echocardiography.


METHODS
A single-blind crossover study in which placebo always preceded the active drug.


METHODS
Ten current crack-smoking subjects, 32 to 47 years of age, with a history of limited previous i.v. cocaine use.


METHODS
PAP, cardiac stroke volume, heart rate, and BP were measured continuously after injection of placebo followed by cocaine HCl (0.5 mg/kg).


RESULTS
i.v. cocaine resulted in no significant change in PAP (-0.14 +/- 3.3[SD] mm Hg, 95% confidence interval [CI] for difference -2.48, +2.21). Stroke volume index showed no significant change after cocaine (-0.1 +/- 2.0 mL; 95% CI, -1.5, +1.3). Heart rate showed a significant increase (10.0 +/- 7.2 min-1; p = 0.0017, 95% CI, +4.9, +15.1). Cardiac index showed a significant increase (0.48 +/- 0.32 L/min; p = 0.0012, 95% CI, +0.25, +0.71). Pulmonary vascular resistance showed no significant change (-44 +/- 101 dyne.s.cm-5/m2, 95% CI, -116, +29).


CONCLUSIONS
i.v. cocaine HCl does not cause short-term increases in PAP or stroke volume index, but causes an increase in cardiac index due to its chronotropic effect.
Kleerup
E C
EC
Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine 90095-1690, USA.
Wong
M
M
Marques-Magallanes
J A
JA
Goldman
M D
MD
Tashkin
D P
DP
D000328:Adult; D002302:Cardiac Output / Q000187:drug effects*; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D016578:Crack Cocaine; D018592:Cross-Over Studies; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009293:Opioid-Related Disorders / Q000503:physiopathology*; D011651:Pulmonary Artery / Q000187:drug effects / Q000502:physiology*; D016037:Single-Blind Method; D013318:Stroke Volume / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D016578:Crack Cocaine; D003042:Cocaine