title: Periodontal healing following reconstructive surgery: effect of guided tissue regeneration.
abstract: Clinical healing following guided tissue regeneration (GTR) in deep intrabony pockets was compared to healing following gingival flap surgery alone (GFS). 15 patients received the GTR treatment including an expanded polytetrafluoroethylene membrane. 13 other patients received the control treatment GFS. A postsurgery protocol emphasizing wound stability and infection control was used. Treatment effects were evaluated 6 months postsurgery. Mean pre-surgery probing depth for the GTR and control treatments was 7.5 +/- 1.0 and 7.7 +/- 1.5 mm, respectively. Significant probing depth reduction (3.8 +/- 1.2 and 2.9 +/- 1.1 mm), attachment level improvement (2.4 +/- 2.1 and 2.2 +/- 1.2 mm) and bone fill (2.0 +/- 2.0 and 2.4 +/- 0.9 mm) followed the GTR and control protocols, respectively (p < 0.01). Significant differences between GTR and control treatments were observed in probing depth reduction (p < 0.01) and in gingival recession increase (1.7 +/- 1.5 and 0.7 +/- 0.9 mm, respectively; p < 0.05). The results suggest that GTR procedures compared to GFS have similar clinical potential in intrabony pockets, under the present protocol.
authors.affiliation: Advanced Education Program in Periodontics, Loma Linda University, CA, USA.
authors.forename: P
authors.initials: P
authors.lastname: Nygaard-Ostby
authors.forename: G
authors.initials: G
authors.lastname: Tellefsen
authors.forename: T J
authors.initials: TJ
authors.lastname: Sigurdsson
authors.forename: G J
authors.initials: GJ
authors.lastname: Zimmerman
authors.forename: U M
authors.initials: UM
authors.lastname: Wikesjö
mesh_terms: D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000601:surgery*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D002710:Chlorhexidine / Q000008:administration & dosage; D003774:Dental Plaque Index; D012534:Dental Scaling; D005260:Female; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D009067:Mouthwashes / Q000008:administration & dosage; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000601:surgery*; D011138:Polytetrafluoroethylene; D011182:Postoperative Care; D013524:Surgical Flaps; D013752:Tetracycline / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D008567:Membranes, Artificial; D009067:Mouthwashes; D011138:Polytetrafluoroethylene; D013752:Tetracycline; D002710:Chlorhexidine