title: [Inhibition of cholesterol biosynthesis in rabbit hepatocytes by 3-beta-(omega-hydroxyalkoxy)cholest-5-enes].
abstract: 3 beta-(2-Hydroxyethoxy)-, 3 beta-(4'-hydroxybutoxy)-, 3 beta-(6-hydroxyhexyloxy)-, 3 beta-(9-hydroxynonyloxy)-, and 3 beta-(2-hydroxy-2-[3H]ethoxy)cholest-5-enes were synthesized. By means of a spin probe, the influence of the synthesized compounds on the phase transition of dimyristoylphosphatidylcholine were estimated. Time and dose dependences of the incorporation of 3 beta-(2-hydroxy-2-[3H]ethoxy)cholest-5-ene into rabbit hepatocytes (the primary culture) were studied. 3 beta-(2-Hydroxyethoxy)- and 3 beta-(4-hydroxybutoxy)cholest-5-enes were shown to inhibit cholesterol biosynthesis from [14C]acetate in rabbit hepatocyte cultures upon a 24-hour preincubation.
authors.forename: A V
authors.initials: AV
authors.lastname: Maliugin
authors.forename: D K
authors.initials: DK
authors.lastname: Novikov
authors.forename: V A
authors.initials: VA
authors.lastname: Kosykh
authors.forename: E I
authors.initials: EI
authors.lastname: Kosenkov
authors.forename: N V
authors.initials: NV
authors.lastname: Medvedeva
authors.forename: N V
authors.initials: NV
authors.lastname: Valentinova
authors.forename: A Ia
authors.initials: AIa
authors.lastname: Shteĭnshneĭder
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Misharin
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D002782:Cholestenes / Q000494:pharmacology*; D002784:Cholesterol / Q000096:biosynthesis*; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D011817:Rabbits
chemical_list: D000924:Anticholesteremic Agents; D002782:Cholestenes; D002784:Cholesterol