title: [Ten-year experience with the use of ofloxacin in reconstructive surgery].
abstract: The data on the use of ofloxacin in more than 300 surgical patients for the last 10 years were analyzed. The results showed that despite the wide clinical use of ofloxacin in the prophylaxis and treatment of postoperative complications the drug remained highly active against the predominating majority of microbes causing surgical infections. Therefore, the broad spectrum, high bactericidal activity and optimal pharmacokinetics with the high biovailability at the level of 95 to 100 per cent provided the use of ofloxacin as a highly efficient agent in the treatment of postoperative infectious complications in surgical inpatients.
authors.forename: N S
authors.initials: NS
authors.lastname: Bogomolova
authors.forename: L V
authors.initials: LV
authors.lastname: Bol'shakov
authors.forename: L N
authors.initials: LN
authors.lastname: Vinogradova
authors.forename: V I
authors.initials: VI
authors.lastname: Sorokina
authors.forename: T D
authors.initials: TD
authors.lastname: Oreshkina
mesh_terms: D000284:Administration, Oral; D000890:Anti-Infective Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001420:Bacteria, Aerobic / Q000187:drug effects*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D004334:Drug Administration Schedule; D006801:Humans; D007262:Infusions, Intravenous; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control*; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents; D015242:Ofloxacin