[The antimicrobial activity of thio-, thioxo- and oxo- derivatives of acridine].
Antimicrobial activity of thio-, thioxo- and oxo- derivatives of acridine has been studied. It was shown, that the majority of compounds possesses the moderate antimicrobial activity. It was established, that acetic acid (6-nitroacridinil-9-thio), piperidine salt (2-ethoxi-6-nitroacridinil-9-thio) and ethyl ether (acridinil-9-thio) of acetic acid show the expressed anti-bacterial activity with respect to gram-positive bacteria. The ethyl ether (acridinil-9-thio) of acetic acid also actively suppresses the growth of similar yeast fungus.
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D000166:Acridines / Q000494:pharmacology*; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006090:Gram-Negative Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D013329:Structure-Activity Relationship
D000166:Acridines; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents