Calcineurin-immunosuppressor complexes.
Crystal structures of the Ser/Thr phosphatase calcineurin (protein phosphatase 2B) have recently been solved by X-ray crystallography, both in the free-protein state, and complexed with the immunophilin/immunosuppressant FKBP12/FK506. Core elements of the calcineurin phosphatase have been found to be similar to the corresponding elements of Ser/Thr phosphatase 1 and purple acid phosphatase. The structures provide a basis for understanding calcineurin inhibition by a ternary complex of immunophilin and immunosuppressant proteins.
Stoddard
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BL
Fred Hutchinson Cancer Research Center, Seattle, Washington 98104-2092, USA. bstoddard@fred.fhcrc.org
Flick
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KE
D001665:Binding Sites; D019703:Calcineurin; D002148:Calmodulin-Binding Proteins / Q000737:chemistry*; D002352:Carrier Proteins / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000494:pharmacology; D006360:Heat-Shock Proteins / Q000737:chemistry* / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000494:pharmacology; D008958:Models, Molecular; D010749:Phosphoprotein Phosphatases / Q000737:chemistry*; D011487:Protein Conformation; D054645:Protein Phosphatase 1; D017433:Protein Structure, Secondary; D022021:Tacrolimus Binding Proteins
D002148:Calmodulin-Binding Proteins; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D006360:Heat-Shock Proteins; D007166:Immunosuppressive Agents; D019703:Calcineurin; D010749:Phosphoprotein Phosphatases; D054645:Protein Phosphatase 1; D022021:Tacrolimus Binding Proteins