title: Examination of coumarins, flavonoids and polysaccharopeptide for antibacterial activity.
abstract: 1. Coumarins, flavonoids and polysaccharopeptide were tested for antibacterial activity. 2. The bacteria used for this study included clinical isolates of Staphylococcus aureus, Shigella flexneri, Salmonella typhi, Escherichia coli and Pseudomonas aeruginosa. 3. Most of the coumarins tested failed to inhibit the bacteria at 25 mg/l. Edultin at 128 mg/l inhibited 4 of the 8 P. aeruginosa strains and 1 of the S. aureus strains tested. O-acetylcolumbianetin and imperatorin did not inhibit any isolate, even at 128 mg/l. 4. When tested at the dose of 128 mg/l, the flavonoids (rutin, naringin and baicalin) inhibited 25% or less of P. aeruginosa and only baicalin was active against S. aureus. 5. Arbutin and 4-(beta-D-glucopyranosyloxyl)-benzaldehyde inhibited 3 of the 8 P. aeruginosa strains when tested at 128 mg/l. 6. Polysaccharopeptide from the fungus Coriolus versicolor failed to inhibit any P. aeruginosa or S. aureus strain at 128 mg/l.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Chinese University of Hong Kong, China.
authors.forename: T B
authors.initials: TB
authors.lastname: Ng
authors.forename: J M
authors.initials: JM
authors.lastname: Ling
authors.forename: Z T
authors.initials: ZT
authors.lastname: Wang
authors.forename: J N
authors.initials: JN
authors.lastname: Cai
authors.forename: G J
authors.initials: GJ
authors.lastname: Xu
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D002681:China; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D003374:Coumarins; D005419:Flavonoids; D011134:Polysaccharides