Synthesis of novel thiazolo[4,5-d]pyrimidine derivatives for antimicrobial, anti-HIV and anticancer investigation.
Some novel thiazolo[4,5-d]pyrimidines containing 6-arylideneamino (3a-e). 2-dicyanomethylidene (5a), 2-(cyanoethoxy carbonyl) methylidene (5b) or 2-hydrazono (7a, b) moieties were synthesized. The prepared compounds were tested in vitro for their antibacterial, antifungal, anti-HIV and anticancer activities. Most of them showed promising antifungal activity, but only a few compounds exhibited anticancer activity.
Rida
S M
SM
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt.
Habib
N S
NS
Badawey
E A
EA
Fahmy
H T
HT
Ghozlan
H A
HA
D000900:Anti-Bacterial Agents; D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D019380:Anti-HIV Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D011743:Pyrimidines; D013844:Thiazoles