Controlling HIV pathogenesis: the role of the noncytotoxic anti-HIV response of CD8+ T cells.
Noncytotoxic CD8+ T cells may play a critical role in preventing progression to disease following human immunodeficiency virus (HIV) infection. This antiviral response, mediated by a novel CD8+ T-cell antiviral factor (CAF), occurs soon after infection and is maintained in asymptomatic individuals. Here, Jay Levy and colleagues propose that this antiviral activity represents a natural cellular immune reaction that controls HIV production and protects the host from potential harmful effects of cytotoxic T lymphocytes.
Levy
J A
JA
Cancer Research Institute, University of California San Francisco 94143-0128, USA. jalevy@itsa.ucsf.edu
Mackewicz
C E
CE
Barker
E
E
D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D006678:HIV / Q000276:immunology* / Q000472:pathogenicity*; D015658:HIV Infections / Q000209:etiology* / Q000276:immunology / Q000382:microbiology*; D006801:Humans