[Effect of docanol on the status of hemostasis and fibrinolysis systems, as well as lipid spectrum in patients with ischemic heart disease depending on the initial level of fibrinolytic activity].
Forty patients with coronary heart disease (CHD) concurrent with hyperlipidemia were divided into 2 groups according to the baseline fibrinolytic activity. The group with the depressed fibrinolytic system displayed the highest atherogenicity index and levels of cholesterol, low and very low density lipoprotein cholesterol and half levels of high density lipoproteins. After 45-day ingestion of docanol, a new Russian food additive containing docosahexanoic and eicosapentaenoic acids there were positive changes in the lipid spectrum in the both groups. The fibrinolytic changes were heterodirectional: activator and plasma activities increased in the group of fibrinolytic depression while in the group of baseline normal fibrinolysis the activity of plasminogen activator fell.
Liutova
L V
LV
Karabasova
M A
MA
Andreenko
G V
GV
Panchenko
V M
VM
Isaev
V A
VA
Sorokaletov
S M
SM
ERshov
A A
AA
D000368:Aged; D004281:Docosahexaenoic Acids / Q000494:pharmacology*; D004338:Drug Combinations; D004537:Eicosanoic Acids / Q000494:pharmacology*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D005527:Food, Fortified; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D006949:Hyperlipidemias / Q000145:classification / Q000150:complications / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000150:complications / Q000188:drug therapy*
D004338:Drug Combinations; D004537:Eicosanoic Acids; D000960:Hypolipidemic Agents; C102856:docanol; D004281:Docosahexaenoic Acids