Effect of iomeprol on renal function immediately after abdominal angiography.
OBJECTIVE
To investigate the acute renal effects of 2 osmolality levels of iomeprol in a double-blind, randomized, parallel-group study.


METHODS
Ten patients received iomeprol 300 mg I/ml, and a further 10 received iomeprol 400 mg I/ml intraarterially at routine abdominal angiography. The mean volume of contrast medium administered was 227.3+/-59.3 ml in the iomeprol 300 group and 221.5+/-30.9 ml in the iomeprol 400 group.


RESULTS
The urinary minute volume increased immediately after angiography, but tended to return to baseline 120 min after the examination. No significant decrease in creatinine clearance occurred; however, the fraction excretion of sodium increased immediately after angiography. The lysosomal enzyme N-acetyl-beta-glucosaminidase and the proximal tubular brush border enzyme gamma-glutamyl transferase increased up to 120 min after the procedure. Free water clearance was negative during each study period. No statistical differences in any parameter were evident between these 2 groups.


CONCLUSIONS
These results suggest that osmotic diuresis and its acute effect on proximal tubular function are induced by the administration of iomeprol, but that these changes are reversible.
Murakami
R
R
Department of Radiology, Nippon Medical School Hospital, Tokyo, Japan.
Tajima
H
H
Kumazaki
T
T
D000005:Abdomen / Q000098:blood supply*; D000118:Acetylglucosaminidase / Q000652:urine; D000328:Adult; D000368:Aged; D000792:Angiography / Q000009:adverse effects*; D003287:Contrast Media / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood / Q000652:urine; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007479:Iopamidol / Q000009:adverse effects / Q000031:analogs & derivatives*; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D012964:Sodium / Q000097:blood / Q000652:urine; D005723:gamma-Glutamyltransferase / Q000652:urine
D003287:Contrast Media; C057937:iomeprol; D012964:Sodium; D003404:Creatinine; D005723:gamma-Glutamyltransferase; D000118:Acetylglucosaminidase; D007479:Iopamidol