title: Assessment of flow in the right human coronary artery by magnetic resonance phase contrast velocity measurement: effects of cardiac and respiratory motion.
abstract: Flow in the human right coronary artery was determined using magnetic resonance phase contrast velocity quantification. Two methods were applied to reduce respiratory motion: Imaging during breath holding, which is fast, and retrospective respiratory gating, which has a high temporal resolution (32 ms) in the cardiac cycle. Vessel cross-sectional area, through-plane velocity, and volume flow were determined in six healthy subjects. In-plane vessel displacement during the cardiac cycle, caused by cardiac contraction, was about 2-4 mm within a time frame of 32 ms in systole and early diastole. The motion resulted in blurring of images obtained during breath holding caused by the large acquisition time window (126 ms) within the cardiac cycle. Therefore, only with a high temporal resolution correct velocity images over the entire cardiac cycle could be obtained. The time- and cross-sectionally averaged velocity was 7 +/- 2 cm/s, and the volume flow was 30 +/- 10 ml/min.
authors.affiliation: Department of Clinical Physics & Engineering, ICaR-VU, Free University, Amsterdam, The Netherlands.
authors.forename: M B
authors.initials: MB
authors.lastname: Hofman
authors.forename: A C
authors.initials: AC
authors.lastname: van Rossum
authors.forename: M
authors.initials: M
authors.lastname: Sprenger
authors.forename: N
authors.initials: N
authors.lastname: Westerhof
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D003326:Coronary Circulation / Q000502:physiology*; D003331:Coronary Vessels / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology; D012119:Respiration / Q000502:physiology; D013997:Time Factors