[Nuclear magnetic resonance and aspects of its use in diagnosis and research on metabolic disorders of skeletal muscles].
Introduction of nuclear magnetic resonance has enabled direct measurements of muscle metabolism in vitro and in vivo. In the presented paper some theoretical and practical applications mainly 31P NMR spectroscopy in research and diagnostics of muscle skeletal diseases are given. In spite of some limitations, the most important advantage of NMR technique is its non-destructive character, the possibility of simultaneous observation of several phosphorylated metabolites in a muscle tissue and the simple method of sample preparation. 31P NMR is a useful tool for studying and detection of muscle diseases and at the same time for its safety for patients.
Lahucký
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Výskumný ústav zivocísnej výroby, Nitra.
Liptaj
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D000818:Animals; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D018482:Muscle, Skeletal / Q000378:metabolism*; D009135:Muscular Diseases / Q000175:diagnosis*