Analysis of the retinohypothalamic tract in congenic albino and pigmented rats.
To determine whether differences in the retinohypothalamic tract (RHT) were related specifically to albinism, we analyzed the distribution and trajectory of this pathway in congenic F344-c/+ albino and pigmented rats using the inactive subunit of cholera toxin conjugated to horseradish peroxidase as an anterograde tracer. We found that the overall volume of the tract in the albino rats was greater than in the pigmented rats (P < 0.05). We also noted shape differences.
Miller
A M
AM
University of Wisconsin-Madison, Neuroscience Training Program 53706, USA.
Chappell
R
R
Obermeyer
W H
WH
Benca
R M
RM
D000417:Albinism / Q000503:physiopathology; D000818:Animals; D002772:Cholera Toxin; D006651:Histocytochemistry; D006735:Horseradish Peroxidase; D007031:Hypothalamus / Q000033:anatomy & histology / Q000166:cytology / Q000502:physiology*; D010858:Pigmentation / Q000502:physiology*; D051381:Rats; D011916:Rats, Inbred F344; D012160:Retina / Q000033:anatomy & histology / Q000166:cytology / Q000502:physiology*; D013493:Suprachiasmatic Nucleus / Q000033:anatomy & histology / Q000166:cytology / Q000502:physiology; D014795:Visual Pathways / Q000033:anatomy & histology / Q000166:cytology / Q000502:physiology*
D002772:Cholera Toxin; D006735:Horseradish Peroxidase