[Immunogenetic aspects of pathogenesis, prognosis and treatment of the main forms of chronic pancreatitis].
Immunogenetic examination comprising determination of erythrocyte antigens (ABO systems and resus-factor) and leukocytes (HLA system) using hemagglutination and compliment-dependent cytotoxicity, respectively, was performed for 138 patients with chronic recurrent pancreatitis, 52 patients with chronic pancreatitis and 456 healthy subjects. Analysis of relations between the above antigens, the disease risk, clinical and laboratory parameters, readings of ultrasound histogram and the efficacy of treatment helped discover not only provoking and protecting genes, but also some pathogenetic mechanisms involved in genetic predisposition. These findings may be used in the choice of treatment policy and to upgrade the significance of prognosis of principal forms of chronic pancreatitis.
Gubergrits
N B
NB
Medical University, Donetsk.
Khodakovskii
A V
AV
Linevskii
I V
IV
D000017:ABO Blood-Group System / Q000235:genetics / Q000276:immunology*; D000328:Adult; D002908:Chronic Disease; D003602:Cytotoxicity, Immunologic / Q000235:genetics / Q000276:immunology; D004910:Erythrocyte Membrane / Q000276:immunology; D005823:Genetics; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology*; D006384:Hemagglutination / Q000235:genetics / Q000276:immunology; D006801:Humans; D007125:Immunogenetics; D010195:Pancreatitis / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D010641:Phenotype; D011379:Prognosis; D012008:Recurrence; D012307:Risk Factors
D000017:ABO Blood-Group System; D006680:HLA Antigens