title: Clinical evaluation of the bone marrow imaging agent 99Tcm-phytate in the detection of bone metastases.
abstract: The aims of this study were to assess whether 99Tcm-phytate can detect metastatic skeletal lesions, and to compare it with 99Tcm-methylene diphosphonate (99Tcm-MDP) and 99Tcm-labelled human serum albumin nanocolloids (99Tcm-NC). Twenty-four patients with multiple bony metastases, investigated by 99Tcm-MDP whole-body scintigraphy, underwent 99Tcm-phytate bone marrow imaging. A separate bone marrow scintigram with 99Tcm-NC was performed in 20 of the patients. All of the metastatic lesions detected on the 99Tcm-phytate scintigrams exhibited photon-abundant foci only. Most of the 99Tcm-phytate scintigrams detected fewer metastatic lesions than the corresponding bone scintigrams. Visual comparison of the 99Tcm-NC images showed that 13 of 20 99Tcm-NC images were superior to the 99Tcm-phytate images in the detection of metastatic involvement of the skeleton. Thus 99Tcm-phytate should not be used as a bone marrow imaging agent for the detection of skeletal metastases.
authors.affiliation: Department of Nuclear Medicine, Taipei Veterans General Hospital, National Defense Medical Center, Taiwan, Republic of China.
authors.forename: C P
authors.initials: CP
authors.lastname: Chang
authors.forename: R S
authors.initials: RS
authors.lastname: Liu
authors.forename: S M
authors.initials: SM
authors.lastname: Yu
authors.forename: S
authors.initials: S
authors.lastname: Wynchank
authors.forename: L S
authors.initials: LS
authors.lastname: Chu
authors.forename: H Y
authors.initials: HY
authors.lastname: Shiau
authors.forename: T C
authors.initials: TC
authors.lastname: Cheng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000000981:diagnostic imaging*; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010833:Phytic Acid; D011877:Radionuclide Imaging; D013668:Technetium Tc 99m Aggregated Albumin; D013669:Technetium Tc 99m Medronate
chemical_list: D015609:Organotechnetium Compounds; D013668:Technetium Tc 99m Aggregated Albumin; C026177:technetium phytate; D010833:Phytic Acid; D013669:Technetium Tc 99m Medronate