Correction of the spontaneous and DEB-induced chromosomal aberrations in Fanconi anemia cells of the FA(C) complementation group by the FACC gene.
Fanconi anemia (FA) cells are hypersensitive to the cytotoxic and clastogenic effects of DNA cross-linking agents. Four complementation groups have been identified to date. The gene (FACC) that corrects the hypersensitivity of one of them, FA(C), has been cloned. In the present study, both the increased spontaneous and diepoxybutane (DEB)-induced chromosomal instability in FA(C) lymphoblastoid cells were corrected by transfection of FACC.
Stavropoulos
D J
DJ
Department of Biology, McMaster University, Hamilton, Ont. Canada.
Sood
S
S
Tomkins
D J
DJ
Buchwald
M
M
D018797:Cell Cycle Proteins; D002869:Chromosome Aberrations; D004268:DNA-Binding Proteins; D005199:Fanconi Anemia / Q000235:genetics*; D051856:Fanconi Anemia Complementation Group Proteins; D006801:Humans; D009687:Nuclear Proteins; D011506:Proteins / Q000235:genetics*
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D051856:Fanconi Anemia Complementation Group Proteins; D009687:Nuclear Proteins; D011506:Proteins