title: [Contribution of a combination of alpha and beta benzopyrones, flavonoids and natural terpenes in the treatment of lymphedema of the lower limbs at the 2d stage of the surgical classification].
abstract: OBJECTIVE
  To create a phlebolymphologic therapy in order: to activate venous system; to activate lymphatic system; to activate macrophagic system; to reduce the proteic lymphatic load.
  
  
  METHODS
  A study was performed on the use of an ideal phlebolymphological association (Tonka Beans, Gingko Biloba, Melilotus Officinalis) as a practical standpoint in the treatment of lymphedema of lower limbs in order to create an efficacious dose of Coumarin, Benzopyrones and Ginkolidi. CLINICAL: We investigated a population of 76 patients treated in an open-label study for six-eight months with a dosage of Coumarin 60 mg/daily + Gingko Biloba 40 mg/daily + Melilotus 40 mg/daily.
  
  
  CONCLUSIONS
  This trilogy induced a very significant improvement in lymphedema (centimeter-aspect) both in functional symptoms (pain heaviness in affected limbs) and physical signs (edema, episodes of infection). Tolerance of long term treatment was good and the improvement was observed from the third month of treatment.
authors.affiliation: Istituto di Clinica Chirurgica, Università degli Studi, Ferrara.
authors.forename: G
authors.initials: G
authors.lastname: Vettorello
authors.forename: G
authors.initials: G
authors.lastname: Cerreta
authors.forename: A
authors.initials: A
authors.lastname: Derwish
authors.forename: A
authors.initials: A
authors.lastname: Cataldi
authors.forename: A
authors.initials: A
authors.lastname: Schettino
authors.forename: S
authors.initials: S
authors.lastname: Occhionorelli
authors.forename: I
authors.initials: I
authors.lastname: Donini
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage*; D003374:Coumarins / Q000008:administration & dosage*; D004322:Drainage; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006801:Humans; D007866:Leg; D008209:Lymphedema / Q000145:classification / Q000188:drug therapy* / Q000601:surgery; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D000925:Anticoagulants; D003374:Coumarins; D010936:Plant Extracts; C030123:coumarin