[Detection of the functionally active domains in the molecule of the lethal factor of the anthrax exotoxin].
Three functional domains were revealed in the molecule of the lethal factor of B. anthracis. They are located in the linear structure of the molecula as follows: the associative domain occupies the area from Lys39 to Met242, the stabilizing domain from Leu517 to Lys614, and the effector domain still further to the COOH-terminal Lys mino acid.
Noskov
A N
AN
Kravchenko
T B
TB
Noskova
V P
VP
D000595:Amino Acid Sequence; D000818:Animals; D000942:Antigens, Bacterial; D001408:Bacillus anthracis / Q000737:chemistry*; D001427:Bacterial Toxins / Q000302:isolation & purification* / Q000378:metabolism; D001667:Binding, Competitive; D005098:Exotoxins / Q000302:isolation & purification* / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA; D008969:Molecular Sequence Data
D000942:Antigens, Bacterial; D001427:Bacterial Toxins; D005098:Exotoxins; C030325:anthrax toxin