title: Immunohistochemical localization of apolipoprotein E in renal amyloidosis.
abstract: To clarify the role of apolipoprotein E (apo E) in the formation of amyloid deposits, we examined specimens from 11 patients with renal amyloidosis who underwent renal biopsy by an immunohistochemical method using a monoclonal antibody (murine IgG1). Apo E was distributed in the amyloid deposits of all patients in a pattern similar to that obtained with Congo red staining. Strong positive staining for apo E was found on the amyloid deposits in the glomeruli. These results suggest that apo E is a common constituent of amyloid fibrils and that it may be a useful marker for immunohistochemical studies of systemic amyloidosis including renal amyloidosis.
authors.affiliation: Second Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Taniguchi
authors.forename: N
authors.initials: N
authors.lastname: Yorioka
authors.forename: K
authors.initials: K
authors.lastname: Yamashita
authors.forename: H
authors.initials: H
authors.lastname: Oda
authors.forename: L F
authors.initials: LF
authors.lastname: Nie
authors.forename: X F
authors.initials: XF
authors.lastname: Ye Yeu
authors.forename: S
authors.initials: S
authors.lastname: Okushin
authors.forename: Y
authors.initials: Y
authors.lastname: Nishida
authors.forename: S
authors.initials: S
authors.lastname: Kushihata
authors.forename: M
authors.initials: M
authors.lastname: Yamakido
mesh_terms: D000328:Adult; D000686:Amyloidosis; D001057:Apolipoproteins E / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000737:chemistry*; D007674:Kidney Diseases; D008297:Male; D008875:Middle Aged
chemical_list: D001057:Apolipoproteins E