title: Reproducibility of left ventricular size, shape and mass with echocardiography, magnetic resonance imaging and radionuclide angiography in patients with anterior wall infarction. A plea for core laboratories.
abstract: After myocardial infarction, left ventricular volume and ejection fraction can be assessed by echocardiography, magnetic resonance imaging and radionuclide angiography to guide therapy and determine prognosis. Whether a measured parameter gives the same results irrespective of the method used and the observer who performs the analysis is only partly known. Intra-observer and inter-observer variability were determined for echo and magnetic resonance imaging. Left ventricular ejection fraction measured by these techniques was related to radionuclide angiograms performed in the same period. Intra-observer variability for both echo and MRI was low and in most instances below 5%. Inter-observer variability for the echo and MRI measurements were substantially higher than intra-observer variability. Comparison of the three imaging modalities revealed systematic differences. Therefore, in clinical studies, left ventricular volume and function parameters have to be measured with the same technique and by the same observer in qualified core laboratories.
authors.affiliation: Department of Cardiology, University Hospital Leiden, The Hague, The Netherlands.
authors.forename: L H
authors.initials: LH
authors.lastname: Baur
authors.forename: J J
authors.initials: JJ
authors.lastname: Schipperheyn
authors.forename: E A
authors.initials: EA
authors.lastname: van der Velde
authors.forename: E E
authors.initials: EE
authors.lastname: van der Wall
authors.forename: J H
authors.initials: JH
authors.lastname: Reiber
authors.forename: R J
authors.initials: RJ
authors.lastname: van der Geest
authors.forename: P R
authors.initials: PR
authors.lastname: van Dijkman
authors.forename: J G
authors.initials: JG
authors.lastname: Gerritsen
authors.forename: B L
authors.initials: BL
authors.lastname: van Eck-Smit
authors.forename: P J
authors.initials: PJ
authors.lastname: Voogd
authors.forename: A V
authors.initials: AV
authors.lastname: Bruschke
mesh_terms: D000328:Adult; D000368:Aged; D004452:Echocardiography; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D015588:Observer Variation; D011379:Prognosis; D011875:Radionuclide Angiography; D015203:Reproducibility of Results; D013318:Stroke Volume