[The effect of the implantation of the human apo A-I gene on the function of the hepatocyte plasma membrane in rats].
Evidences are given that implantation of human apo A-I gene to experimental animals induces essential changes in the functional state of hepatocyte plasmatic phospholipid composition, hyperpolarization development, as well as changes in the Na, K-ATPase and adenylate cyclase activities. The presence of generalized cell reaction is evidenced from the fact than biosynthesis of summary proteins gets enhanced during the above changes.
Frol'kis
V V
VV
Kordium
V A
VA
Novikova
S N
SN
Irodov
D V
DV
Kul'chitskiĭ
O K
OK
Sabko
V E
VE
Kobzar'
A L
AL
Potapenko
R I
RI
Bogatskaia
L N
LN
Muradian
Kh K
KhK
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D016632:Apolipoprotein A-I / Q000235:genetics*; D002462:Cell Membrane / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology*; D018014:Gene Transfer Techniques; D006801:Humans; D008081:Liposomes; D008099:Liver / Q000378:metabolism*; D008563:Membrane Lipids / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013997:Time Factors
D016632:Apolipoprotein A-I; D008081:Liposomes; D008563:Membrane Lipids; D008565:Membrane Proteins; D000262:Adenylyl Cyclases; D000254:Sodium-Potassium-Exchanging ATPase