title: Structure and function of the protein tyrosine phosphatases.
abstract: The tyrosine and dual-specificity phosphatases are involved in signaling, cell growth and differentiation, and the cell cycle. The enzymes share a common catalytic mechanism mediated by an active site cysteine, arginine and aspartic acid. Supplementary domains assist in targeting and substrate specificity.
authors.affiliation: Biophysics Research Division, University of Michigan, Ann Arbor 48109-1055, USA.
authors.forename: E B
authors.initials: EB
authors.lastname: Fauman
authors.forename: M A
authors.initials: MA
authors.lastname: Saper
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D018797:Cell Cycle Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D017124:Conserved Sequence; D000458:Cyanobacteria / Q000201:enzymology; D050756:Cyclin-Dependent Kinase Inhibitor Proteins; D054637:Dual-Specificity Phosphatases; D006801:Humans; D006868:Hydrolysis; D008958:Models, Molecular; D008969:Molecular Sequence Data; D008970:Molecular Weight; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D010766:Phosphorylation; D019000:Phosphotyrosine / Q000378:metabolism; D011487:Protein Conformation; D017027:Protein Tyrosine Phosphatases / Q000737:chemistry* / Q000378:metabolism*; D054558:Protein Tyrosine Phosphatases, Non-Receptor; D016992:Rhodobacter / Q000201:enzymology; D029701:Saccharomyces cerevisiae Proteins; D012475:Salmonella / Q000201:enzymology; D013379:Substrate Specificity; D014443:Tyrosine / Q000378:metabolism; D020687:cdc25 Phosphatases
chemical_list: C074860:CDC14 protein, S cerevisiae; D018797:Cell Cycle Proteins; D050756:Cyclin-Dependent Kinase Inhibitor Proteins; D029701:Saccharomyces cerevisiae Proteins; D019000:Phosphotyrosine; D014443:Tyrosine; D010749:Phosphoprotein Phosphatases; C489855:dual specificity phosphatase 12; C084429:CDKN3 protein, human; D054637:Dual-Specificity Phosphatases; D017027:Protein Tyrosine Phosphatases; D054558:Protein Tyrosine Phosphatases, Non-Receptor; D020687:cdc25 Phosphatases; C099588:myotubularin