Review of the transmucosal drug delivery.
The epithelial barriers limits the quantity of drug that can be delivered by a topical route for either local or systemic treatment. Any chemical that can help to reversibly minimize the epithelial barriers would improve drug uptake. Permeabilizers are such chemicals, and their mode of action generally involves fluidization of the intracellular lipid in the epithelial barrier. The vehicle in which the permeabilizers is delivered is equally important and needs to be specifically tailored to the solubility properties of the drug. Therefore, the selection of the appropriate permeabilizer and vehicle can make the delivery of medication across the oral mucosa a feasible option.
Manganaro
A M
AM
Oral and Maxillofacial Pathology, New Brooke Army Medical Center, Hospital Dental Clinic, Fort Sam Houston, San Antonio, TX 78234, USA.
D000042:Absorption; D000284:Administration, Oral; D016503:Drug Delivery Systems; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D009061:Mouth Mucosa / Q000378:metabolism*; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism*; D010599:Pharmacokinetics
D004364:Pharmaceutical Preparations