Airway epithelial cells produce stem cell factor.
Airway epithelial cells modulate the inflammatory response in asthmatic, allergic and fibrotic lung diseases through the secretion of cytokines that regulate the movement and activation of inflammatory cells. Mast cells play an important role in the pathogenesis of these lung diseases. In this study we report that normal airway epithelial cells express stem cell factor which is a critical mediator of mast cell growth and differentiation and that transforming growth factor-beta inhibits secretion of stem cell factor by airway epithelial cells.
Wen
L P
LP
Stanford University School of Medicine, Pulmonary and Critical Care Division, CA 94305-5236, USA.
Fahrni
J A
JA
Matsui
S
S
Rosen
G D
GD
D001980:Bronchi / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D002454:Cell Differentiation; D002455:Cell Division; D002457:Cell Extracts; D002460:Cell Line; D002461:Cell Line, Transformed; D002462:Cell Membrane; D003600:Cytosol; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D008407:Mast Cells / Q000166:cytology; D012333:RNA, Messenger / Q000032:analysis; D019089:Stem Cell Factor / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics; D016212:Transforming Growth Factor beta / Q000494:pharmacology
D002457:Cell Extracts; D012333:RNA, Messenger; D019089:Stem Cell Factor; D016212:Transforming Growth Factor beta