title: Projection structure of a gap junction membrane channel at 7 A resolution.
abstract: Electron cryo-microscopy and image analysis of frozen-hydrated, two-dimensional crystals of gap junction membrane channels formed by recombinant alpha 1 connexin (Cx43) reveal a ring of transmembrane alpha-helices that lines the aqueous pore and a second ring of alpha-helices in close contact with the membrane lipids.
authors.forename: V M
authors.initials: VM
authors.lastname: Unger
authors.forename: N M
authors.initials: NM
authors.lastname: Kumar
authors.forename: N B
authors.initials: NB
authors.lastname: Gilula
authors.forename: M
authors.initials: M
authors.lastname: Yeager
mesh_terms: D000818:Animals; D002460:Cell Line; D018031:Connexin 43 / Q000737:chemistry* / Q000378:metabolism; D006224:Cricetinae; D018360:Crystallography, X-Ray; D008563:Membrane Lipids / Q000378:metabolism; D008854:Microscopy, Electron / Q000379:methods; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D018031:Connexin 43; D008563:Membrane Lipids; D011994:Recombinant Proteins