title: Isolation of cholesteryl ester transfer protein inhibitors from Panax ginseng roots.
abstract: We have isolated cholesteryl ester transfer protein (CETP) inhibitors from the extract of Korean Panax ginseng C. A. Meyer roots and identified them as polyacetylene analogs. These compounds inhibit human CETP with IC50 values of around 20-35 mg/ml.
authors.affiliation: Korea Research Institute of Bioscience & Biotechnology, Taejon.
authors.forename: B M
authors.initials: BM
authors.lastname: Kwon
authors.forename: J Y
authors.initials: JY
authors.lastname: Nam
authors.forename: S H
authors.initials: SH
authors.lastname: Lee
authors.forename: T S
authors.initials: TS
authors.lastname: Jeong
authors.forename: Y K
authors.initials: YK
authors.lastname: Kim
authors.forename: S H
authors.initials: SH
authors.lastname: Bok
mesh_terms: D002352:Carrier Proteins / Q000037:antagonists & inhibitors*; D053480:Cholesterol Ester Transfer Proteins; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006023:Glycoproteins; D006801:Humans; D005894:Panax / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal; D011994:Recombinant Proteins / Q000737:chemistry
chemical_list: C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D006023:Glycoproteins; D010936:Plant Extracts; D011994:Recombinant Proteins