Biological activities of synthetic triterpenoid and steroid beta-D-xylopyranosyl-(1-->6)-beta-D-glucopyranosides.
Comparisons of the activities of diosgenyl, methyl glycyrrhetinate or digitoxigenyl 3-O-beta-D-xylopyranosyl-(1-->6)-beta-D-glucopyranoside with those of our previous glycosides supported our assumptions that both haemolytic and antifungal activities of steroid saponins are generally parallel to each other, while almost all haemolytic triterpenoid saponins show no antifungal activity, and that both antiviral and anti-ATPase activities of cardiac glycosides having a (1-->6) sugar linkage are much lower than those of the others.
Takechi
M
M
Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka, Japan.
Uno
C
C
Tanaka
Y
Y
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000818:Animals; D000935:Antifungal Agents; D000998:Antiviral Agents; D002240:Carbohydrate Sequence; D006461:Hemolysis / Q000187:drug effects*; D006564:Herpesviridae / Q000187:drug effects; D013256:Steroids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014249:Trichophyton / Q000187:drug effects; D014315:Triterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D000935:Antifungal Agents; D000998:Antiviral Agents; D013256:Steroids; D014315:Triterpenes; D000251:Adenosine Triphosphatases