IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease.
Organ-specific autoimmune diseases are mediated by interferon gamma (IFN-gamma)-producing T helper 1 (Th1) cells. Here, Martin Röcken and colleagues review the experimental basis for an antigen-specific therapeutic approach to inflammatory autoimmune diseases. This strategy involves selective deviation of harmful Th1 responses towards an anti-inflammatory, interleukin 4 (IL-4)-producing Th2 phenotype.
Röcken
M
M
Dept of Dermatology, Ludwig-Maximilians-University Munich, Germany.
Racke
M
M
Shevach
E M
EM
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology* / Q000628:therapy*; D000939:Epitopes / Q000627:therapeutic use*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000517:prevention & control; D007167:Immunotherapy / Q000639:trends*; D015847:Interleukin-4 / Q000276:immunology* / Q000627:therapeutic use*
D000939:Epitopes; D015847:Interleukin-4