[The combination of oral lysine-acetylsalicylate and metoclopramide compared with oral sumatriptan in the treatment of migraine attacks. A randomized, double-blind, placebo-controlled clinical trial].
A combination of lysine acetylsalicylate (equivalent to 900 mg aspirin) and 10 mg metoclopramide (LAS + MTC) was compared with oral sumatriptan (100 mg) and placebo in 421 patients with migraine in a randomized, double-blind, clinical trial. LAS + MTC was as effective as sumatriptan with a decrease in headache from severe or moderate to mild or none in 57% and 53%, respectively, for the first migraine attack treated, the primary efficacy parameter. Both treatments were better than placebo (success rate 24%, p < 0.001). LAS + MTC was better tolerated than sumatriptan (adverse events in 18% and 28%, respectively, p < 0.05).
Tfelt-Hansen
P
P
Neurologisk afdeling, Bispebjerg Hospital, København.
Henry
P
P
Mulder
L J
LJ
Scheldewaert
R G
RG
Schoenen
J
J
Chazot
G
G
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D000932:Antiemetics / Q000008:administration & dosage*; D001241:Aspirin / Q000008:administration & dosage*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008239:Lysine / Q000008:administration & dosage*; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage*; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000932:Antiemetics; D008239:Lysine; D008787:Metoclopramide; D001241:Aspirin