Characteristics and significance of the amorphous state in pharmaceutical systems.
The amorphous state is critical in determining the solid-state physical and chemical properties of many pharmaceutical dosage forms. This review describes the characteristics of the amorphous state and some of the most common methods that can be used to measure them. Examples of pharmaceutical situations where the presence of the amorphous state plays an important role are presented. The application of our current knowledge to pharmaceutical formulation problems is illustrated, and some strategies for working with amorphous character in pharmaceutical systems are provided.
Hancock
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BC
Merck Frosst Canada Inc., Pointe Claire-Dorval, Quebec.
Zografi
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D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D014961:X-Ray Diffraction