title: Precluding uracil from DNA.
abstract: Two enzymes, dUTP pyrophosphatase and uracil-DNA glycosylase, prevent the misincorporation of uracil into the genome in distinct manners. The atomic structures of these proteins complexed with substrate analogs reveal the structural basis for uracil recognition and suggest a novel mechanism of DNA repair.
authors.affiliation: International Institute for Advanced Research, Central Research Laboratories, Matsushita Electric Industrial Company Limited, Kyoto, Japan. dmitry@crl.mei.co.jp
authors.forename: D G
authors.initials: DG
authors.lastname: Vassylyev
authors.forename: K
authors.initials: K
authors.lastname: Morikawa
mesh_terms: D001665:Binding Sites; D004247:DNA / Q000378:metabolism*; D045647:DNA Glycosylases; D004260:DNA Repair / Q000502:physiology; D003857:Deoxyuridine / Q000378:metabolism; D008958:Models, Molecular; D009699:N-Glycosyl Hydrolases / Q000737:chemistry* / Q000378:metabolism; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D011755:Pyrophosphatases / Q000737:chemistry* / Q000378:metabolism; D014498:Uracil / Q000378:metabolism*; D051981:Uracil-DNA Glycosidase
chemical_list: D014498:Uracil; D004247:DNA; D045647:DNA Glycosylases; D009699:N-Glycosyl Hydrolases; D051981:Uracil-DNA Glycosidase; D011755:Pyrophosphatases; C020020:dUTP pyrophosphatase; D003857:Deoxyuridine