title: [Initial results with withdrawal treatments of male and female participants in the diversified Janus opiate prescription project in Basel].
abstract: Since the beginning of the 'Janus' opiate project in Basel in which severely opiate-dependent persons are treated intravenously with heroin, morphine or methadone 11 from 160 participants (to november 1995) were treated in the withdrawal and intervention unit at the psychiatry clinic of the university of Basel. 7 patients sought a total, 4 a partial withdrawal. Whereas the 4 patients wanting withdrawal from consumption of drugs in addition to study drugs all reached their goal 4 of the 7 persons aiming at total withdrawal interrupted treatment prematurely. The 3 patients who were successful are-as far as the authors know-still off opiates. Substitution of intravenous opiates provided by 'Janus' with oral methadone and slow tapering off of the latter over days to weeks occurred mostly without problems. Participants of the 'Janus' project thus desired a withdrawal oriented treatment with equal frequency and had not less success than persons substituted with oral methadone in achieving this goal.
authors.affiliation: Psychiatrische Universitätsklinik, Basel.
authors.forename: R
authors.initials: R
authors.lastname: Stohler
authors.forename: I
authors.initials: I
authors.lastname: Hug
authors.forename: B
authors.initials: B
authors.lastname: Knoll
authors.forename: B
authors.initials: B
authors.lastname: Mohler
authors.forename: D
authors.initials: D
authors.lastname: Ladewig
mesh_terms: D000328:Adult; D005260:Female; D003932:Heroin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008691:Methadone / Q000008:administration & dosage / Q000627:therapeutic use*; D009020:Morphine / Q000008:administration & dosage / Q000627:therapeutic use*; D016320:Substance Abuse Treatment Centers; D019966:Substance-Related Disorders / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D003932:Heroin; D009020:Morphine; D008691:Methadone