title: Kikuchi's disease: a case report with emphasis on flow cytometric studies.
abstract: We describe a case of 27 year-old female presenting with Kikuchi-Fujimoto's disease whose diagnosis was based on histopathologic and immunophenotypic studies. The illness was characterized by fever, urinary tract infections, skin rash, polyarthritis, generalized lymphadenopathy, pancytopenia, hepatic cytolysis and cholestasis, abnormal coagulation tests and elevated serum lactate dehydrogenase. The lymph node biopsy was consistent with the diagnosis of a histiocytic necrotizing lymphadenitis. Flow cyto-metric studies performed on the affected lymph node, bone marrow aspirate and peripheral blood, revealed a relative expansion of mature activated T lymphocytes, predominantly expressing a CD8 (+) phenotype.
authors.affiliation: Service of Clinical Hematology, Sto Antonio's Hospital, Porto Portugal.
authors.forename: M
authors.initials: M
authors.lastname: Lima
authors.forename: F
authors.initials: F
authors.lastname: Silvestre
authors.forename: J
authors.initials: J
authors.lastname: Correia
authors.forename: J
authors.initials: J
authors.lastname: Oliveira
authors.forename: B
authors.initials: B
authors.lastname: Justiça
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D001853:Bone Marrow / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000473:pathology*; D005260:Female; D005434:Flow Cytometry; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000473:pathology; D008199:Lymphadenitis / Q000145:classification / Q000175:diagnosis / Q000473:pathology*; D009336:Necrosis
chemical_list: D015703:Antigens, CD