[Steryl cellosolves--regulators of cholesterol metabolism in isolated rabbit hepatocytes].
Synthesis of 3 beta-(2-hydroxyethoxy)cholest-5-ene, 3 beta-(2-hydroxyethoxy)cholest-5-en-7-one, 3 beta-(2-hydroxyethoxy)-7 beta-hydroxycholest-5-ene, 3 beta-(2-hydroxyethoxy)-5 alpha, 6 alpha-epoxycholestane, and 3 beta-(2-hydroxyethoxy) -5 alpha, 6 beta-dihydroxycholestane was described. Substances obtained inhibited cholesterol biosynthesis in the rabbit hepatocyte cell culture with ID 50 from 5.5(+/-0.7) x 10(-8) to 1.3(+/-0.2) x 10(-5) M and also to a remarkable extent the cell protein biosynthesis.
Maliugin
A V
AV
Shteĭnshneĭder
A Ia
AIa
Kosykh
V A
VA
Alquier
C
C
Lafont
H
H
Misharin
A Iu
AIu
D000818:Animals; D002478:Cells, Cultured; D002784:Cholesterol / Q000096:biosynthesis / Q000378:metabolism*; D005026:Ethylene Glycols / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D011817:Rabbits
D005026:Ethylene Glycols; D000960:Hypolipidemic Agents; D011500:Protein Synthesis Inhibitors; D002784:Cholesterol