[The phenomenon of focal sympathetic denervation of the major vessels in the development of atherosclerosis].
22 aortas obtained from people aged 20-55 who died in accidents by early dissections were studied. Adrenergic nerve plexuses of aortal wall were examined by quantitative neurohistochemical method. Focal reduction of indexes of these plexuses density was defined by the age of 30. The process of desympathization runs unevenly with nerve plexuses from zones of aorta cranial to areas of its branching altered to greater extent. This very zones are subjected to atherosclerosis selectively. We tend to consider the process of desympathization for one of atherosclerosis factors developing in vascular wall zones with the loss of adaptive-trophic influence of the vegetative nervous system sympathetic activity.
Shvalev
V N
VN
Kargina-Terent'eva
R A
RA
Kareeva
N I
NI
D000328:Adult; D001011:Aorta / Q000294:innervation / Q000473:pathology*; D001161:Arteriosclerosis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013194:Staining and Labeling / Q000379:methods; D013564:Sympathetic Nervous System / Q000473:pathology*