title: Effects of processing conditions and in vitro ageing on the physical properties of Biomer.
abstract: Biomer is generally processed by repeated deposition of layers by solution casting onto a preshaped former. The precise nature of this processing route may influence the mechanical response and surface properties of the finished article and, as a result, its subsequent in vivo behaviour. Here we have studied the influence of a range of processing parameter: the type of former, the initial concentration of the solution from which the layers are cast and the time interval between casting of successive layers. The subsequent variation of physico-chemical properties on vitro ageing in isotonic saline solution has also been considered and, in particular, the possibility of cross-linking during long-term exposure.
authors.affiliation: Ecole Polytechnique Fédérale de Lausanne, Switzerland.
authors.forename: F
authors.initials: F
authors.lastname: Orang
authors.forename: C J
authors.initials: CJ
authors.lastname: Plummer
authors.forename: H H
authors.initials: HH
authors.lastname: Kausch
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism / Q000592:standards; D003432:Cross-Linking Reagents / Q000737:chemistry; D004356:Drug Storage; D005612:Freeze Drying; D008970:Molecular Weight; D011140:Polyurethanes / Q000737:chemistry* / Q000378:metabolism / Q000592:standards; D016062:Porosity; D013718:Tensile Strength
chemical_list: D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D011140:Polyurethanes; C031892:biomer