title: [The prevalence of markers for the hepatitis A and B viruses in the population of Gijón between 6 and 25 years old].
abstract: BACKGROUND
  The aim of this study was to know the prevalence of previous infection markers for hepatitis A and B viruses in a pediatric-juvenile population from Gijón, Spain.
  
  
  METHODS
  A representative (according to the census) transversal randomized sample of a population from 6 to 25 years in age from Gijón, Spain, was included in the study analyzing demographic, epidemiologic and clinical variables, liver tests, anti-HAV IgG and anti-HBc.
  
  
  RESULTS
  Of the 630 individuals selected a demographic error was detected in 28 (4.4%) and 453 subjects were studied (71.9%) in whom the anti-HAV IgG was positive in 37 cases (8.75% of prevalence adjusted for age), with 4.4% (12/271) (CI 95% 2.3%-7.6%) for the younger cases and 13.7% (25/182) (CI 95% 9.1%-19.6%) in the group ranging from 18 to 25 years in age (p < 0.001). No anti-HAV IgG positive case was detected in the population under the age of 10 years. Among the young adults the prevalence of anti-HAV IgG positive cases was higher in those born in the south of Spain (2/6, 33.3%) (CI 95% 4.3%-77.7%) with respect to those from the northern regions of Spain (9/259, 3.5%) (CI 95% 1.6%-6.4%). (p = 0.02). With respect to HBV markers, of the 433 unvaccinated cases, 6 (1.4%) presented markers of past infection and 2 (0.46%) HBsAg positivity. Both had normal serum ALT without viral replication. Six cases of hypertransaminasemia levels (1.3%) were detected all being related with obesity or alcoholism. All the cases with previous acute clinical hepatitis were found to be anti-HAV IgG positive and anti-HBc negative.
  
  
  CONCLUSIONS
  The current prevalence of anti-HAV IgG in the population from 6 to 25 years from Gijón, Spain is very low and given the high degree of susceptibility (86%) for HAV infection in the young adult population (18-25 years) the implementation of vaccination programs is recommended even without previous serologic screening. The low prevalence of anti-Hbc would also undervalue its use as prevaccination screening against HB in this geographical area.
authors.affiliation: Sección de Aparato Digestivo, MIR Hospital de Cabueñes, Gijón.
authors.forename: A
authors.initials: A
authors.lastname: Suárez
authors.forename: C A
authors.initials: CA
authors.lastname: Navascués
authors.forename: R
authors.initials: R
authors.lastname: García
authors.forename: B
authors.initials: B
authors.lastname: Peredo
authors.forename: D
authors.initials: D
authors.lastname: Miguel
authors.forename: M T
authors.initials: MT
authors.lastname: Menéndez
authors.forename: C
authors.initials: C
authors.lastname: Saro
authors.forename: F
authors.initials: F
authors.lastname: Román
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006506:Hepatitis A / Q000453:epidemiology / Q000276:immunology; D006508:Hepatitis Antibodies / Q000097:blood*; D006509:Hepatitis B / Q000453:epidemiology / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000097:blood*; D006507:Hepatovirus / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D015995:Prevalence; D011897:Random Allocation; D016036:Seroepidemiologic Studies; D013030:Spain / Q000453:epidemiology; D014505:Urban Population / Q000706:statistics & numerical data
chemical_list: D015415:Biomarkers; D006508:Hepatitis Antibodies; D006510:Hepatitis B Antibodies; D007074:Immunoglobulin G