[The effect of long-term UV radiation exposure on the skin autonomous microflora and on body nonspecific resistance].
Hairless mice of strain HRS were exposed to vertical UV-B-irradiation (280-320 nm) at daily doses of 1 or 2 kJ/m2 (biologically effective doses 200 and 400 J/m2) five days a week for 13 and 6 weeks. As the length of exposure increased, the abundance of automicroflora of the dorsal skin first decreased, then exceeded the control value, was normalized, and remained at the normal level until the end of the experiment. The rates of effect appearance and disappearance, just as its amplitude, increased with the daily doses. No changes were found in resistance to staphylococcal alpha-toxin after its post-irradiation intraperitoneal injection.
Strzhizhovskiĭ
A D
AD
Lobacheva
G V
GV
D000818:Animals; D000917:Antibody Formation / Q000528:radiation effects; D001427:Bacterial Toxins / Q000494:pharmacology; D004351:Drug Resistance / Q000528:radiation effects; D006460:Hemolysin Proteins / Q000494:pharmacology; D007111:Immunity, Cellular / Q000528:radiation effects; D007113:Immunity, Innate / Q000528:radiation effects*; D051379:Mice; D008812:Mice, Hairless; D012062:Relative Biological Effectiveness; D012867:Skin / Q000382:microbiology* / Q000528:radiation effects*; D013211:Staphylococcus aureus; D013997:Time Factors; D014466:Ultraviolet Rays / Q000009:adverse effects*
D001427:Bacterial Toxins; D006460:Hemolysin Proteins; C021091:staphylococcal alpha-toxin