CYP2E1 genotypes and serum LAP in Japanese alcoholics.
The genotypes of the ALDH2 and CYP2E1 loci of Japanese alcoholic patients were determined to investigate the susceptibility to alcoholic liver injury. In alcoholics with a liver-function disorder, a significant association was observed between the genotypes of the CYP2E1 loci and the serum level of a liver-derived enzyme, LAP. However, there was no significant association between the ALDH2 genotypes and liver dysfunction.
Miyatake
R
R
Department of Neuropsychiatry, Kagawa Medical School, Kita-gun, Japan.
Suwaki
H
H
Nakamura
K
K
Matsuo
Y
Y
Iwahashi
K
K
D000437:Alcoholism / Q000201:enzymology / Q000235:genetics* / Q000503:physiopathology; D000444:Aldehyde Dehydrogenase / Q000235:genetics; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007564:Japan; D007931:Leucyl Aminopeptidase / Q000097:blood*; D008099:Liver / Q000201:enzymology / Q000503:physiopathology; D008108:Liver Diseases, Alcoholic / Q000201:enzymology / Q000235:genetics* / Q000503:physiopathology
D019392:Cytochrome P-450 CYP2E1; C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D007931:Leucyl Aminopeptidase