Treatment of childhood cutaneous T-cell lymphoma with alpha-interferon plus PUVA.
All forms of cutaneous T-cell lymphoma are rare in childhood. We describe an 8-year-old boy with plaque-stage mycosis fungoides stage IIA whose cutaneous eruption had been present for 5 years. Histologic examination revealed the presence of a granulomatous infiltrate together with atypical lymphocytes within the dermis. The child had an excellent response to combination psoralen-UVA (PUVA) with interferon-alpha 2a treatment and is currently in remission.
Tay
Y K
YK
Department of Dermatology, University of Colorado Health Sciences Center, Denver 80262, USA.
Weston
W L
WL
Aeling
J L
JL
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001706:Biopsy; D002648:Child; D005500:Follow-Up Studies; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D016410:Lymphoma, T-Cell, Cutaneous / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D011701:PUVA Therapy; D012074:Remission Induction; D012867:Skin / Q000473:pathology
D000970:Antineoplastic Agents; D016898:Interferon-alpha