Molecular machinery mediating vesicle budding, docking and fusion.
A general machinery buds and fuses transport vesicles which connect intracellular compartments with each other and allow communication with the extracellular environment. Cytoplasmic coat proteins deform membranes to bud vesicles and interact directly or indirectly with cargo molecules. Compartment-specific SNAREs (SNAP receptors) on vesicles and target membranes dock vesicles and provide a scaffolding for the general fusion machinery to initiate lipid bilayer fusion.
Söllner
T H
TH
Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Rothman
J E
JE
D002213:Capsid / Q000378:metabolism; D018699:Coated Vesicles / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000378:metabolism; D008051:Lipid Bilayers / Q000378:metabolism; D008561:Membrane Fusion / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D050600:SNARE Proteins; D013572:Synaptic Vesicles / Q000378:metabolism; D033921:Vesicular Transport Proteins
D008051:Lipid Bilayers; D008565:Membrane Proteins; D050600:SNARE Proteins; D033921:Vesicular Transport Proteins