[Effect of FUT-187, oral serine protease inhibitor, on inflammation in the gastric remnant].
Excessive enterogastric reflux following partial gastrectomy is believed to be responsible for the cause of inflammation in the gastric remnant. We examined the effect of FUT-187, a synthetic serine protease inhibitor, on symptoms and endoscopic findings in 33 patients who were diagnosed endoscopically as postgastrectomy gastritis. Patients took 50 mg FUT-187 orally after each meal and at bedtime for 8 weeks. Before treatment, 30 patients (91%) suffered from several symptoms including regurgitation and/or bitter taste in the mouth (49%), epigastric pain (42%) and nausea (36%). From endoscopic observation, erythema was detected in 32 patients, edema in 23 patients and erosion and/or ulcer in 9 patients. After treatment the global improvement rating for subjective symptoms was 76.7% (23/30) and the improvement of endoscopic findings was 63.6% (21/33). Diarrhea was observed in one patient but could be easily controlled by discontinuation of the drug. Our results suggest that FUT-187 can be a useful drug for the treatment of postgastrectomy gastritis with its efficacy and safety.
Shiozaki
H
H
Dept. of Surgery II, Osaka University, Medical School.
Inoue
M
M
Tamura
S
S
Iwanaga
T
T
Imaoka
M
M
Furukawa
H
H
Hiratsuka
M
M
Kikkawa
N
N
Kobayashi
K
K
Okamura
J
J
Takada
N
N
Ogawa
Y
Y
Yamada
T
T
Takami
M
M
Takada
T
T
Okuda
H
H
Yano
T
T
Satomi
T
T
Kawasaki
T
T
Oshima
S
S
Yamasaki
K
K
Imamoto
H
H
Noguchi
S
S
Fujimoto
N
N
Mori
T
T
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D005743:Gastrectomy / Q000009:adverse effects*; D018530:Gastric Stump; D005756:Gastritis / Q000188:drug therapy*; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy*; D011480:Protease Inhibitors / Q000627:therapeutic use*
D007093:Imidazoles; D011480:Protease Inhibitors; C058875:sepimostate mesilate