A rat mutation producing demyelination (dmy) maps to chromosome 17.
A recessive mutation exhibiting severe myelin breakdown, mainly at the level of the lumbar segments of the spinal cord and without any associated inflammation, was discovered in a partially inbred rat colony. Analysis of the segregation patterns of a set of polymorphic microsatellite markers in two inter-strain crosses allowed the mapping of this autosomal recessive mutation to rat Chromosome (Chr) 17, very close to the prolactin (Prl) locus, in a region homologous to human Chr 6p21.2-22.3 and mouse Chr 13. The pathology of the demyelination process and the chromosomal localization indicate that this mutation has no known equivalent in either mouse or human.
Kuramoto
T
T
Institute of Laboratory Animals, Faculty of Medicine, Kyoto University, Japan.
Sotelo
C
C
Yokoi
N
N
Serikawa
T
T
Goñalons Sintes
E
E
Cantó Martorell
J
J
Guénet
J L
JL
D000818:Animals; D001947:Breeding; D002874:Chromosome Mapping; D003711:Demyelinating Diseases / Q000235:genetics*; D005260:Female; D005808:Genes, Recessive; D006801:Humans; D008161:Lumbosacral Region; D008297:Male; D051379:Mice; D018895:Microsatellite Repeats; D009154:Mutation; D009186:Myelin Sheath / Q000378:metabolism; D010641:Phenotype; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000473:pathology