title: Anaphylactic shock after aprotinin reexposure: time course of aprotinin-specific antibodies.
abstract: We report a case of severe anaphylactic shock during a cardiac operation that occurred as a consequence of aprotinin readministration in the presence of preformed aprotinin-specific antibodies. Both immunoglobulin G (3 hours) and immunoglobulin E (5 minutes) antibody levels dropped early after the clinical event. Despite their possibly limited clinical significance, we still recommend the conductance of specific antibody screening tests before readministration of aprotinin.
authors.affiliation: Department of Surgery, Eberhard-Karls-University, Tuebingen, Germany.
authors.forename: A M
authors.initials: AM
authors.lastname: Scheule
authors.forename: M J
authors.initials: MJ
authors.lastname: Jurmann
authors.forename: H P
authors.initials: HP
authors.lastname: Wendel
authors.forename: L
authors.initials: L
authors.lastname: Häberle
authors.forename: F S
authors.initials: FS
authors.lastname: Eckstein
authors.forename: G
authors.initials: G
authors.lastname: Ziemer
mesh_terms: D000368:Aged; D000707:Anaphylaxis / Q000139:chemically induced* / Q000276:immunology; D000906:Antibodies / Q000276:immunology; D007611:Aprotinin / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D005260:Female; D006350:Heart Valve Prosthesis; D006490:Hemostatics / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007431:Intraoperative Complications / Q000276:immunology*; D013997:Time Factors
chemical_list: D000906:Antibodies; D006490:Hemostatics; D007074:Immunoglobulin G; D007073:Immunoglobulin E; D007611:Aprotinin