title: Leser-Trélat sign with anaplastic ependymoma--an autopsy case.
abstract: A 36-year-old Japanese male, who 7 years previously had been diagnosed as having an ependymoma in the left parietal region, had received surgery, chemotherapy and radiotherapy. He later developed a rapid growth of multiple skin lesions on his back and extremities, which coincided with a regrowth of the tumor. Postmortem examination revealed that the ependymoma showed anaplastic transformation and necrosis; however, no malignancy was observed in the extracranial organs. The skin lesions were histologically diagnosed as seborrheic keratoses. We have, therefore, diagnosed the patient as having Leser-Trélat sign associated with anaplastic ependymoma.
authors.affiliation: Department of Neuropathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hamada
authors.forename: T
authors.initials: T
authors.lastname: Iwaki
authors.forename: H
authors.initials: H
authors.lastname: Muratani
authors.forename: S
authors.initials: S
authors.lastname: Imayama
authors.forename: M
authors.initials: M
authors.lastname: Fukui
authors.forename: J
authors.initials: J
authors.lastname: Tateishi
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D001932:Brain Neoplasms / Q000473:pathology*; D004806:Ependymoma / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D017492:Keratosis, Seborrheic / Q000473:pathology*; D008297:Male
chemical_list: D014408:Biomarkers, Tumor