title: [Control mechanisms of cell transition from the G1 phase to the S phase--the R point].
abstract: The critical moment of regulation when transition of the cell from the G1 to the S phase takes which is decisive for its division is the so-called R-point (restriction point). The disorder of molecular mechanisms controlling the passage of the cell through this site is an associated manifestation of most tumourous processes. A considerable part of this mechanism is the RB protein, binding transcription factors needed for the activation of genes effective in the S phase. Its binding capacity depends on the extent of phosphorylation and on the activity of the appropriate kinases and their inhibitors.
authors.affiliation: Danish Cancer Soc., Div. Tumor Biol., Copenhagen.
authors.forename: J
authors.initials: J
authors.lastname: Bártek
authors.forename: L
authors.initials: L
authors.lastname: Lukás
authors.forename: M
authors.initials: M
authors.lastname: Strauss
mesh_terms: D018844:Cyclin-Dependent Kinases / Q000502:physiology; D016213:Cyclins / Q000502:physiology; D016193:G1 Phase / Q000502:physiology*; D005786:Gene Expression Regulation; D016160:Retinoblastoma Protein / Q000502:physiology; D016196:S Phase / Q000502:physiology*
chemical_list: D016213:Cyclins; D016160:Retinoblastoma Protein; D018844:Cyclin-Dependent Kinases