title: Enhancement of erectile responses to vasoactive drugs by a variable amplitude oscillation device.
abstract: The limitations of intracavernosal injection (ICI) of vaso-active drugs as a diagnostic tool in the evaluation of erectile dysfunction are well recognized and, prominently, include the artifacts induced by the unfamiliar environment on the patient. We report on the benefits of adding a vibratory stimulus to ICI to improve the sensitivity of this test in a population of 170 patients with erectile dysfunction who were evaluated using a standard protocol. Intracavernosal pressure was measured following ICI alone and ICI with vibratory stimulation of the penis. A statistically significant improvement in intracavernosal pressure (ICP) with the addition of vibration was observed in 87% of the subjects as compared to ICI. In 52% the improvement in ICP was greater than 20% over that achieved by ICI. This study showed that the addition of vibration to intracavernosal administration of vaso-active drugs significantly increases the erectile response in a controlled and reproducible manner. Vibratory stimulation provides a better reflection of erectile potential than the pharmacological challenge alone.
authors.affiliation: Department of Urology, Queen's University, Kingston, Ontario, Canada.
authors.forename: S S
authors.initials: SS
authors.lastname: Chun
authors.forename: J
authors.initials: J
authors.lastname: Fenemore
authors.forename: J P
authors.initials: JP
authors.lastname: Heaton
authors.forename: B
authors.initials: B
authors.lastname: Johnston
authors.forename: A
authors.initials: A
authors.lastname: Morales
mesh_terms: D000328:Adult; D000368:Aged; D000527:Alprostadil / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D018783:Impotence, Vasculogenic / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010208:Papaverine / Q000008:administration & dosage / Q000627:therapeutic use; D010410:Penile Erection / Q000187:drug effects*; D010413:Penis / Q000098:blood supply; D010646:Phentolamine / Q000008:administration & dosage / Q000627:therapeutic use; D010812:Physical Stimulation; D011312:Pressure; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D014732:Vibration
chemical_list: D014665:Vasodilator Agents; D010208:Papaverine; D000527:Alprostadil; D010646:Phentolamine