title: Radical resection of radiation-induced sarcoma of the chest wall: report of 15 cases.
abstract: BACKGROUND
  Surgical management of radiation-induced sarcoma of the chest wall remains difficult because of its impressive local aggressiveness.
  
  
  METHODS
  Between 1987 and 1995, 15 patients (median age, 58 years) underwent radical resection of radiation-induced sarcoma of the chest wall. This type of tumor was defined as a metachronous, histologically different neoplasm in the irradiated field of the original tumor. Ten patients had a history of primary breast cancer and 5 patients, Hodgkin's disease. The median delivered radiation dose to the primary tumor area was 45 Gy, and the median interval between radiotherapy and diagnosis of sarcoma was 14 years. Seven tumors were located on the sternum, three on the lateral chest wall, and five in the thoracic outlet. Four total and three partial sternectomies, three lateral chest wall resections and five resections of tumors in the thoracic outlet (three first-rib resections) were performed. Seven patients required stabilization of the chest wall with prosthetic material. Soft tissue reconstruction was carried out with either muscle flaps and skin advancement in 9, musculocutaneous flaps in 4, or skin flaps alone in 2 patients.
  
  
  RESULTS
  One patient died 3 months after total sternectomy of respiratory failure. Two patients (13.3%) had a local complication: sepsis after sternectomy in 1 and cutaneous necrosis in 1. Local recurrence occurred in 7 patients after a median interval of 10 months. Two of them died, and 4 underwent a repeat resection, 3 of whom are still alive. Four patients died of systemic recurrence. With a median follow-up of 30 months, overall 5-year survival and 5-year disease-free survival rates were 48% and 27%, respectively.
  
  
  CONCLUSIONS
  Despite poor long-term disease-free survival, radical resection of radiation-induced sarcoma of the chest wall is justified on the basis of low postoperative morbidity and the lack of other available therapies.
authors.affiliation: Department of Thoracic and Vascular Surgery, Hôpital Marie-Lannelongue, Paris-Sud University, Le Plessis-Robinson, France.
authors.forename: A R
authors.initials: AR
authors.lastname: Chapelier
authors.forename: E A
authors.initials: EA
authors.lastname: Bacha
authors.forename: V T
authors.initials: VT
authors.lastname: de Montpreville
authors.forename: E M
authors.initials: EM
authors.lastname: Dulmet
authors.forename: M
authors.initials: M
authors.lastname: Rietjens
authors.forename: A
authors.initials: A
authors.lastname: Margulis
authors.forename: P
authors.initials: P
authors.lastname: Macchiarini
authors.forename: P G
authors.initials: PG
authors.lastname: Dartevelle
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D009381:Neoplasms, Radiation-Induced / Q000401:mortality / Q000601:surgery*; D016609:Neoplasms, Second Primary / Q000401:mortality / Q000601:surgery*; D011879:Radiotherapy Dosage; D012086:Reoperation; D015996:Survival Rate; D013899:Thoracic Neoplasms / Q000209:etiology* / Q000401:mortality / Q000601:surgery*; D013997:Time Factors