title: Inhibitory effect of arphamenine A on intestinal dipeptide transport.
abstract: Arphamenine A, an Arg-Phe analog without a peptide bond, has been reported to be a possible inhibitor of the peptide transporter [H. Daniel and S.A. Adibi, FASEB J., 8, 753 (1994)]. The present study demonstrated that arphamenine A is not a real inhibitor, but is a substrate for the transporter, being transported transepithelially under a proton gradient. The substrate specificity of the peptide transporter was wider than expected.
authors.affiliation: Department of Applied Biological Chemistry, Graduate School of Agriculture and Life Sciences, University of Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Enjoh
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: S
authors.initials: S
authors.lastname: Arai
authors.forename: M
authors.initials: M
authors.lastname: Shimizu
mesh_terms: D001693:Biological Transport, Active / Q000187:drug effects; D018938:Caco-2 Cells; D002352:Carrier Proteins / Q000378:metabolism; D004151:Dipeptides / Q000378:metabolism*; D004594:Electrophysiology; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000187:drug effects; D018408:Patch-Clamp Techniques; D011480:Protease Inhibitors / Q000494:pharmacology*
chemical_list: D002352:Carrier Proteins; D004151:Dipeptides; D006146:Guanidines; D011480:Protease Inhibitors; C040038:arphamenine A