The effect of methimazole on the growth of the developing brushtail possum, Trichosurus vulpecula.
The brushtail possum, Trichosurus vulpecula, produces a single offspring 200 mg in body weight. The young grow slowly during the first half of pouch of life at approximately 1g/day. At day 96 post partum the growth rate increases dramatically and it has been suggested that this change in growth rate may result from the initiation of thyroid function in the young possum. To determine the role of the thyroid gland of the possum on growth, the production of hormones from the thyroid was inhibited by administration of the drug, methimazole. The drug was administered to adult and young possums at day 140 post partum for 28 days and to young at day 100 post partum for 42 days and the effects of this treatment on plasma concentrations of thyroxine and on growth were monitored. Methimazole was found to inhibit thyroxine production in 4 of the 6 adult possums although it had no effect on body weight. Similar treatment administered to nine young possums inhibited growth. The three surviving methimazole possum young treated at 100 days post partum weighed less than control possums after day 163 post partum. The four young treated at 140 days post partum also showed depression in growth rate. However, the depression was not as marked as that of the 100 day treated possums. It is highly likely therefore that the surge in growth rate in the possum at day 96 post partum is initiated by thyroxine produced by the thyroid gland of the young.
Buaboocha
W
W
Department of Anatomical Sciences, University of Queensland, St. Lucia, Brisbane, Australia.
Gemmell
R T
RT
D000818:Animals; D013956:Antithyroid Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D005260:Female; D008297:Male; D008713:Methimazole / Q000494:pharmacology*; D009893:Opossums / Q000254:growth & development*; D013974:Thyroxine / Q000097:blood
D013956:Antithyroid Agents; D008713:Methimazole; D013974:Thyroxine