title: Pulmonary parenchymal abnormalities in congenital diaphragmatic hernia.
abstract: Congenital diaphragmatic hernia results in abnormal lung development. There is a global hypoplasia with both lungs affected, the ipsilateral lung more severely. This results in a reduction in the number of bronchial divisions and a decrease in the quantity and maturity of the alveoli. The pneumocytes are dysfunctional, resulting in a total quantitative and qualitative reduction in surfactant and a decrease in antioxidant enzyme activity.
authors.affiliation: Department of Paediatric Surgery, Great Ormond Street Children's Hospital, NHS Trust, London, United Kingdom.
authors.forename: D T
authors.initials: DT
authors.lastname: Wilcox
authors.forename: M S
authors.initials: MS
authors.lastname: Irish
authors.forename: B A
authors.initials: BA
authors.lastname: Holm
authors.forename: P L
authors.initials: PL
authors.lastname: Glick
mesh_terms: D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D008168:Lung / Q000002:abnormalities*; D011663:Pulmonary Surfactants / Q000032:analysis; D017382:Reactive Oxygen Species
chemical_list: D011663:Pulmonary Surfactants; D017382:Reactive Oxygen Species