Radioresistance, chemoresistance, and apoptosis resistance. The past, present, and future.
A wide variety of cancer therapy resistance mechanisms are available, with perhaps surprising overlap between causes of chemotherapy and radiation resistance. As previously discussed, most of the widely used chemotherapeutic agents and gamma-radiation utilize apoptosis as the common death pathway, thereby making apoptosis and the ability to manipulate apoptosis of integral importance to the future of cancer therapy. This is evidenced by the information explosion on this topic in the last 5 years. Obviously much remains to be learned. However, with the aforementioned cooperation of the oncology team and a greater understanding of the molecular mechanisms behind cancer and cancer therapy resistance, response rates, survival times, the quality of life of patients enduring antineoplastic therapies, and the importance of comparative oncology can only increase. We look forward to the findings in the coming years on this incredibly clinically relevant topic with great fondness and uncertainty.
Bergman
P J
PJ
Department of Cell Biology, M.D. Anderson Cancer Center, Houston, Texas, USA.
Harris
D
D
D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000528:radiation effects*; D004249:DNA Damage; D004358:Drug Therapy / Q000639:trends / Q000662:veterinary*; D004361:Drug Tolerance; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000662:veterinary; D011830:Radiation Effects; D018787:Radiation Oncology; D011836:Radiation Tolerance; D011878:Radiotherapy / Q000639:trends / Q000662:veterinary*