title: HLA-DQA1 in autochthonous Basques: description of a genocline for the DQA1*0201 allele in Europe.
abstract: A total of 250 autochthonous Basque individuals were tested in the HLA-DQA1 system, and the allele frequency distribution found was significantly different from that of any other European population. The differences centre mainly on the alleles DQA1*0201 and DQA1*0501: for the former the Basques have the highest frequency described anywhere in the world (f = 0.210) and for the latter they have the lowest frequency in Europe (f = 0.204). For the allele DQA1*0201 a genocline is also described in Europe with the Basques and Finno-Ugric populations basically at the extremes. The genocline reflects the isolation of the Basque population since prehistoric times, and supports existing linguistic, archaeological and genetic data.
authors.affiliation: Animali Biologia eta Genetika Saila, Zientzi Fakultatea, Euskal Herriko Unibertsitatea, Leioa, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Iriondo
authors.forename: C
authors.initials: C
authors.lastname: Manzano
authors.forename: C
authors.initials: C
authors.lastname: de la Rúa
mesh_terms: D000328:Adult; D000483:Alleles; D003431:Cross-Cultural Comparison; D005060:Europe; D005260:Female; D005787:Gene Frequency / Q000235:genetics*; D005828:Genetics, Population; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction
chemical_list: D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen