title: Urinary clearance of angiotensin II in Pekin ducks.
abstract: To quantify the renal excretion of angiotensin II (AII) in birds, synthetic AII was intravenously infused into conscious Pekin ducks at rates of 5, 15 and 45 ng/kg/min for 30 min and the relationships between plasma and urine AII concentrations were monitored by radioimmunoassay. The infusions of AII produced dose-dependent elevations in the plasma concentrations of the hormone, however, urinary concentrations and excretion rates did not change significantly from the basal values of 11.6 +/- 1.2 pg/ml and 4.3 +/- 1.0 pg/min, respectively. The metabolic clearance rate of AII remained constant at each infusion dose (approximately 120 ml/min/kg). The urinary clearance rates (< 0.3 ml/min/kg) indicated that the fraction of AII cleared from the blood via the urine was less than 0.2%. Clearly, excretion of intact AII via this route is not a quantitatively important means of elimination for this hormone in birds.
authors.affiliation: Department of Physiology, University of the Witwatersrand, Johannesburg, South Africa.
authors.forename: D A
authors.initials: DA
authors.lastname: Gray
authors.forename: M
authors.initials: M
authors.lastname: Frescura
mesh_terms: D000704:Analysis of Variance; D000804:Angiotensin II / Q000493:pharmacokinetics*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004372:Ducks / Q000652:urine*; D005260:Female; D007668:Kidney / Q000502:physiology*; D008297:Male; D008657:Metabolic Clearance Rate; D011863:Radioimmunoassay
chemical_list: D000804:Angiotensin II