title: Development of donor-derived prostate cancer in a recipient following orthotopic heart transplantation.
abstract: OBJECTIVE
  To report the development of metastatic prostate cancer in a heart transplant recipient without a primary focus in the recipient prostate gland; to present genetic evidence suggesting transplantation of the malignancy from the donor.
  
  
  METHODS
  Histological analysis of donor prostate and recipient prostate and rib. Molecular genetic analysis of prostate and kidney tissue from the donor and peripheral blood leukocytes and rib tissue from the transplant recipient.
  
  
  METHODS
  University of Pennsylvania Medical Center.
  
  
  RESULTS
  Multiple biopsies of recipient prostate were negative for malignancy but recipient rib contained prostatic adenocarcinoma with osteoblastic bone response. Molecular genetic analysis of recipient rib specimen, which contained both histologically normal and neoplastic cells, was shown to contain a combination of alleles from the donor and recipient at 4 loci.
  
  
  CONCLUSIONS
  Although this is a single case report of an uncommon event, genotyping of polymorphic dinucleotide repeat elements from 4 different chromosomal regions provides strong evidence that the tumor cells arose from donor tissue and were transplanted along with the cardiac allograft.
authors.affiliation: Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA.
authors.forename: E
authors.initials: E
authors.lastname: Loh
authors.forename: F J
authors.initials: FJ
authors.lastname: Couch
authors.forename: C
authors.initials: C
authors.lastname: Hendricksen
authors.forename: L
authors.initials: L
authors.lastname: Farid
authors.forename: P F
authors.initials: PF
authors.lastname: Kelly
authors.forename: M A
authors.initials: MA
authors.lastname: Acker
authors.forename: J E
authors.initials: JE
authors.lastname: Tomaszewski
authors.forename: S B
authors.initials: SB
authors.lastname: Malkowicz
authors.forename: B L
authors.initials: BL
authors.lastname: Weber
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology / Q000235:genetics / Q000473:pathology / Q000556:secondary; D000483:Alleles; D001706:Biopsy; D001859:Bone Neoplasms / Q000209:etiology / Q000235:genetics / Q000473:pathology / Q000556:secondary; D002886:Chromosomes, Human, Pair 17; D004273:DNA, Neoplasm / Q000032:analysis*; D005819:Genetic Markers; D005838:Genotype; D016027:Heart Transplantation / Q000009:adverse effects; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000473:pathology; D007963:Leukocytes, Mononuclear / Q000166:cytology; D008207:Lymphatic Metastasis / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology; D011471:Prostatic Neoplasms / Q000209:etiology / Q000235:genetics / Q000473:pathology; D012272:Ribs / Q000473:pathology; D014019:Tissue Donors
chemical_list: D004273:DNA, Neoplasm; D005819:Genetic Markers