Troglitazone inhibits angiotensin II-induced DNA synthesis and migration in vascular smooth muscle cells.
Angiotensin II (AII) plays a crucial role in controlling the proliferation and migration of vascular smooth muscle cells (VSMCs). The present study was undertaken to determine if troglitazone (Tro) has an effect on the G-protein coupled signaling through AII type I (AT-1) receptors in cultured rat aortic VSMCs. AII-induced MAP kinase activation was inhibited 67.9% by Tro. AII-induced DNA synthesis and migration was completely inhibited by Tro or by the AT-1 receptor blocker irbesartan. The present study demonstrates that troglitazone inhibits AII-induced DNA synthesis, migration and MAP kinase activation in VSMCs which are important molecular events for the development of neointimal hyperplasia and atherosclerosis.
Graf
K
K
University of Southern California, School of Medicine, Department of Medicine, Los Angeles 90033, USA. graf@hsc.usc.edu.
Xi
X P
XP
Hsueh
W A
WA
Law
R E
RE
D000804:Angiotensin II / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism; D002465:Cell Movement; D002478:Cells, Cultured; D002839:Chromans / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis* / Q000187:drug effects; D004789:Enzyme Activation; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013844:Thiazoles / Q000494:pharmacology*; D045162:Thiazolidinediones; D000077288:Troglitazone; D014662:Vasoconstrictor Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D002839:Chromans; D007004:Hypoglycemic Agents; D013844:Thiazoles; D045162:Thiazolidinediones; D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D004247:DNA; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D000077288:Troglitazone