Experimental neurotrophic factor therapy leads to cortical synaptic remodeling and compensates for behavioral deficits.
This brief review discusses experimental therapy with neurotrophic factors in a model of central nervous system (CNS) neural atrophy and synaptic loss resulting from unilateral cortical infarctions. It discusses the trophic factor protection of the cholinergic phenotype of neurons belonging to the forebrain-to-neocortex projection, as well as the capacity of trophic therapy to elicit synaptogenesis in the cerebral cortex of adult animals. Finally, it addresses the behavioral consequences of trophic factor-induced synaptic remodeling of the neocortex in this model.
Cuello
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AC
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
D000818:Animals; D001284:Atrophy; D001522:Behavior, Animal / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects* / Q000503:physiopathology; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000503:physiopathology; D009414:Nerve Growth Factors / Q000494:pharmacology* / Q000627:therapeutic use*; D009416:Nerve Regeneration; D009419:Nerve Tissue Proteins / Q000494:pharmacology* / Q000627:therapeutic use*; D009434:Neural Pathways / Q000187:drug effects; D009473:Neuronal Plasticity / Q000187:drug effects; D010641:Phenotype; D012333:RNA, Messenger / Q000187:drug effects; D051381:Rats; D013569:Synapses / Q000187:drug effects
D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger