title: Papillary-cystic tumor of the pancreas.
abstract: A case of papillary cystic tumor (PCT) of the pancreas in a 40-yr-old woman is reported. This rare neoplasm was discovered fortuitously by a CT-scan examination for a palpable abdominal uterine leiomyoma. Percutaneous fine-needle aspiration (FNA) of the pancreatic mass was performed under CT-scan guidance. Cytologic examination of the material gave the diagnosis of PCT, which was confirmed by histologic examination of the resected tumor. Immunohistochemical staining showed a high degree of positivity to wide-spectrum anticytokeratin and anticytokeratin 20, and a weak positivity to anti-NSE antibody. In addition, the tumor cells were highly reactive for progesterone antibody, while they were negative for estrogen. These findings suggest a ductal origin for PCT, and also suggest that sex hormones may play a role in its growth, but not in its genesis. We emphasize the value of FNA cytologic features in the diagnosis of these rare tumors.
authors.affiliation: Institut de Pathologie Clinique, Hôpital Cantonal Universitaire de Genève, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Remadi
authors.forename: W
authors.initials: W
authors.lastname: Mac Gee
authors.forename: I
authors.initials: I
authors.lastname: Doussis-Anagnostopoulou
authors.forename: S D
authors.initials: SD
authors.lastname: Berger
authors.forename: A
authors.initials: A
authors.lastname: Ismail
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D001707:Biopsy, Needle; D018292:Cystadenoma, Papillary / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D015415:Biomarkers