Localization of presenilin-1 mRNA in rat brain.
We examined the regional and cellular distribution of presenilin-1 gene expression in the rat brain by in situ hybridization. Microscopic analysis demonstrated that presenilin-1 mRNA is predominantly expressed in areas such as the occipital cortex, the pyramidal layer of the hippocampus, thalamic nuclei and the cerebellar granular layer. The expression of presenilin-1 is mostly neuronal: only a weak hybridization signal was found in the corpus callosum and in the astrocytoma cell lines U373MG and U138MG.
Quarteronet
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Rhône-Poulenc Rorer, Biology/Neurochemistry, CRVA, Vitry sur Seine, France.
Pradier
L
L
Czech
C
C
Delalonde
L
L
Burgevin
M C
MC
Doble
A
A
Petitet
F
F
D000818:Animals; D001921:Brain / Q000378:metabolism*; D017403:In Situ Hybridization; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D053764:Presenilin-1; D051381:Rats
D008565:Membrane Proteins; D053764:Presenilin-1