title: [Clinical experience with the use of ofloxacin in infections of the upper and lower urinary tracts: demonstrations of the results of clinical trials].
abstract: The efficacy and safety of ofloxacin in the treatment of upper and lower urinary tract infections were studied with the drug use according to 4 regimens by comparison with nitrofurantoin in the treatment of lower urinary tract infections and trimethoprim/sulfamethoxazole in the treatment of upper urinary tract infections. Ofloxacin was used in doses of 100 to 200 mg once or twice a day for 3, 5 and 10 days. In a separate group of 30 female patients with frequent recurring noncomplicated lower urinary tract infections ofloxacin was used in a dose of 50 mg once a day for 6 months. Ofloxacin was shown to be highly efficient in the treatment of medium and severe infections of the upper and lower urinary tracts. The following regimens were recommended: 200 mg once a day in the treatment of medium urinary tract infections, 100 mg twice a day for 3 to 7 days in the treatment of severe infections of the lower urinary tract and 200 mg twice a day for 7 to 10 days in the treatment of severe upper urinary tract infections. The use of ofloxacin in a daily dose of 50 mg for 6 months proved to be efficient in the treatment of frequent acute recurring infections of the urinary tracts.
authors.affiliation: Municipal Hospital, Frankfurt am Main, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Liudvig
mesh_terms: D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D009582:Nitrofurantoin / Q000627:therapeutic use*; D015242:Ofloxacin / Q000009:adverse effects / Q000627:therapeutic use*; D012008:Recurrence; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D000892:Anti-Infective Agents, Urinary; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D009582:Nitrofurantoin; D015242:Ofloxacin