title: Surgery for refractory glaucoma.
abstract: OBJECTIVE
  To determine the surgical outcome of mitomycin trabeculectomy in patients with refractory glaucoma.
  
  
  METHODS
  Sixty-six eyes of 52 patients with refractory glaucoma underwent mitomycin trabeculectomy. Mitomycin was applied for five minutes only once during trabeculectomy. The follow-up period was six to 61 months.
  
  
  RESULTS
  Cumulative success probability was calculated using Kaplan-Meier life-table analysis assuming the cut-off postoperative IOP to be 20 mmHg or IOP reduction by at least 20% in eyes with preoperative IOP 24 mmHg. At the end of 61-month follow-up the success probability was 80% +/- 6% without postoperative ocular hypotensive medication (complete success) and was 95% +/- 3% regardless of postoperative antiglaucoma medication (overall success), respectively.
  
  
  CONCLUSIONS
  The data suggest that mitomycin trabeculectomy is efficacious in reducing IOP in patients with refractory glaucoma.
authors.affiliation: Department of Ophthalmology, Gifu University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kitazawa
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: A
authors.initials: A
authors.lastname: Sawada
authors.forename: Y
authors.initials: Y
authors.lastname: Hagiwara
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017024:Chemotherapy, Adjuvant; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D019384:Nucleic Acid Synthesis Inhibitors / Q000008:administration & dosage*; D011183:Postoperative Complications; D012307:Risk Factors; D014130:Trabeculectomy; D016896:Treatment Outcome
chemical_list: D019384:Nucleic Acid Synthesis Inhibitors; D016685:Mitomycin