title: GH-IGF axis during catch up growth in small for gestational age (SGA) infants.
abstract: The hormonal profile in 47 small for gestational age (SGA) term newborns during their first year of life was studied. The newborns had a mean birth weight of 2290 +/- 230 g and a length of 45.5 +/- 2.0 cm, and they were followed up every month. Serum IGF-I, IGF-II, and urinary growth hormone (u-GH) concentrations were measured at 3 days of age and every 3 months during one year. Serum IGFBP-3 levels were measured at 3 and 6 months of age. Catch up growth (CUG) was defined as an increase in length z score greater than 1 SD between birth and 6 months of age. According to this definition, 27 infants (57.4%) experienced CUG. We compared the hormonal profile of the infants who demonstrated evidence of CUG [CUG(+)] with those who did not [CUG(-)]. Serum IGF-II levels were significantly higher in CUG(+) infants compared to CUG(-) infants at 3 months of age. We did not find any differences in serum IGF-I, IGFBP-3 and urinary GH between CUG(+) and CUG(-) infants at any time during the study.
authors.affiliation: Instituto de Investigaciones Materno Infantil, Facultad de Medicina, Universidad de Chile, Hospital San Borja Arriarán, Santiago, Chile.
authors.forename: H
authors.initials: H
authors.lastname: García
authors.forename: C
authors.initials: C
authors.lastname: Henriquez
authors.forename: F
authors.initials: F
authors.lastname: Ugarte
authors.forename: E
authors.initials: E
authors.lastname: Fernandez
authors.forename: F
authors.initials: F
authors.lastname: Beas
authors.forename: G
authors.initials: G
authors.lastname: Iñiguez
authors.forename: A
authors.initials: A
authors.lastname: Boric
authors.forename: F
authors.initials: F
authors.lastname: Pizarro
authors.forename: F
authors.initials: F
authors.lastname: Cassorla
mesh_terms: D001724:Birth Weight; D001827:Body Height; D005260:Female; D019382:Human Growth Hormone / Q000652:urine*; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000254:growth & development* / Q000502:physiology*; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D008297:Male
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II