Pathogenic role of antiprotein-phospholipid antibodies.
Antiphospholipid antibodies (aPL) are a heterogeneous family of antibodies, including those specific for a variety of phospholipid (PL)-binding proteins and also those reacting with PL molecules. The former seem to be associated with the antiphospholipid syndrome (APS). At present, the main proteins proposed as antigens are beta 2 glycoprotein I, prothrombin, protein C, protein S, kininogens and annexin V. Anionic PL might play a key role "in vivo" in the binding of aPL to PL-bound proteins. Different mechanisms may be involved in the pathogenesis of the APS, including effects of aPL on the protein C system and antithrombin III and also on platelets, endothelial cells and monocytes. Recent data on experimental animal models have provided support for a causative role of aPL in the clinical complications of the APS.
Carreras
L O
LO
University Institute of Biomedical Sciences, Favaloro Foundation, Buenos Aires, Argentina.
Forastiero
R R
RR
D000818:Animals; D017304:Annexin A5 / Q000276:immunology; D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D016736:Antiphospholipid Syndrome / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology*; D002417:Cattle; D015777:Eicosanoids / Q000096:biosynthesis; D004730:Endothelium, Vascular / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D005342:Fibrinolysis; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D007704:Kininogens / Q000276:immunology; D051379:Mice; D008817:Mice, Mutant Strains; D011486:Protein C / Q000037:antagonists & inhibitors / Q000276:immunology; D017293:Protein S / Q000276:immunology; D011516:Prothrombin / Q000276:immunology; D011817:Rabbits; D013927:Thrombosis / Q000276:immunology*; D053482:beta 2-Glycoprotein I
D017304:Annexin A5; D017152:Antibodies, Antiphospholipid; D015777:Eicosanoids; D006023:Glycoproteins; D007704:Kininogens; D011486:Protein C; D017293:Protein S; D053482:beta 2-Glycoprotein I; D011516:Prothrombin