title: Long-term follow-up after radiofrequency modification of the atrioventricular node in patients with atrial fibrillation.
abstract: OBJECTIVE
  The purpose of this study was to describe the long-term follow-up results in 62 patients with atrial fibrillation and an uncontrolled ventricular rate, who underwent radiofrequency modification of the atrioventricular (AV) node.
  
  
  BACKGROUND
  Previous studies in small numbers of patients have suggested that radiofrequency modification may be effective in controlling the ventricular rate in patients with atrial fibrillation, but long-term follow-up data have been lacking.
  
  
  METHODS
  The subjects of this study were 62 consecutive patients (mean age +/- SD 65 +/- 14 years; 43 with structural heart disease) who underwent an attempt at radiofrequency modification of the AV node because of symptomatic, drug-refractory atrial fibrillation with an uncontrolled ventricular rate. The atrial fibrillation was chronic in 46 patients and paroxysmal in 16. Radiofrequency energy was applied to the posteroseptal or mid-septal right atrium to lower the ventricular rate in atrial fibrillation to 120 to 130 beats/min during an infusion of 4 micrograms/min of isoproterenol.
  
  
  RESULTS
  Short-term control of the ventricular rate was successfully achieved without the induction of pathologic AV block in 50 (81%) of 62 patients. Inadvertent high degree AV block occurred in 10 (16%) of 62 patients, with the AV block occurring at the time of the procedure in 6 patients and 36 to 72 h after the procedure in 4. During 19 +/- 8 months of follow-up (range 4 to 33), 5 (10%) of 50 patients had a symptomatic recurrence of an uncontrolled rate during atrial fibrillation. Overall, adequate rate control at rest and during exertion, without pathologic AV block, was achieved long term in 45 (73%) of 62 patients. Among 37 patients with a successful outcome, left ventricular ejection fraction increased from (mean +/- SD) 0.44 +/- 0.14 to 0.51 +/- 0.10 one year later (p < 0.001). Complications other than AV block included polymorphic ventricular tachycardia 10 to 24 h after the procedure in two patients who had a predisposing factor for ventricular tachycardia and sudden death 1 to 5 months after the procedure in two patients with idiopathic dilated cardiomyopathy, one of whom had a pacemaker for AV block.
  
  
  CONCLUSIONS
  In approximately 70% of properly selected patients with atrial fibrillation and an uncontrolled ventricular rate, radiofrequency modification of the AV node results in excellent long-term control of the ventricular rate at rest and during exertion.
authors.affiliation: Department of the Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0022, USA.
authors.forename: F
authors.initials: F
authors.lastname: Morady
authors.forename: C
authors.initials: C
authors.lastname: Hasse
authors.forename: S A
authors.initials: SA
authors.lastname: Strickberger
authors.forename: K C
authors.initials: KC
authors.lastname: Man
authors.forename: E
authors.initials: E
authors.lastname: Daoud
authors.forename: F
authors.initials: F
authors.lastname: Bogun
authors.forename: R
authors.initials: R
authors.lastname: Goyal
authors.forename: M
authors.initials: M
authors.lastname: Harvey
authors.forename: B P
authors.initials: BP
authors.lastname: Knight
authors.forename: R
authors.initials: R
authors.lastname: Weiss
authors.forename: M
authors.initials: M
authors.lastname: Bahu
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D001283:Atrioventricular Node / Q000503:physiopathology / Q000601:surgery*; D017115:Catheter Ablation / Q000009:adverse effects; D002908:Chronic Disease; D015716:Electrocardiography, Ambulatory; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006327:Heart Block / Q000209:etiology; D006801:Humans; D008297:Male; D013997:Time Factors; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000502:physiology