title: Sulthiame-associated mild compensated metabolic acidosis.
abstract: Sulthiame is effectively used in the treatment of benign and symptomatic focal epilepsy in children. Hyperventilation as a symptom is a well known adverse effect of the drug. Alterations of the acid-base equilibrium have been described for the drug, however, very infrequently only in adults without a detailed evaluation of the disorders status. The case presented here demonstrates a mild compensated metabolic acidosis in a child which, for the first time, is described using the methods of complete blood gas and electrolytes analysis.
authors.affiliation: Department of Clinical Pharmacology, Hospital of the Otto-von-Guericke-University, Magdeburg, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Tröger
authors.forename: C
authors.initials: C
authors.lastname: Fritzsch
authors.forename: J
authors.initials: J
authors.lastname: Darius
authors.forename: J
authors.initials: J
authors.lastname: Gedschold
authors.forename: F P
authors.initials: FP
authors.lastname: Meyer
mesh_terms: D000138:Acidosis / Q000097:blood / Q000139:chemically induced*; D000927:Anticonvulsants / Q000009:adverse effects*; D001784:Blood Gas Analysis; D002675:Child, Preschool; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy; D006801:Humans; D008297:Male; D013843:Thiazines / Q000009:adverse effects*; D000096926:Benzenesulfonamides
chemical_list: D000927:Anticonvulsants; D013843:Thiazines; C084593:sulthiame; D000096926:Benzenesulfonamides