[Changes in the blood morphofunctional characteristics of cyprinid fishes in ammonia poisoning].
Changes in the carp blood and hemoglobin caused by action of threshold levels (0.1 mg/1 litre) of ammonia have been investigated. A decrease in the quantity of erythrocytes, increase in the amount of leucocytes and hematocrit are determined. Concentration of oxyhemoglobin falls. General hemoglobin, desoxyhemoglobin and, particularly, methemoglobin increase. Changes in the curve of dissociation of oxyhemoglobin with a shift to the right, which causes an increase in P50 are found. Ammonia induces an increase in hemoglobin sensibility to denaturation effects of acids and alkalis. Modification of functions and structure of hemoglobin is in close connection with such indices of blood and hemoglobin as pH, concentration of 2,3-DFG, ammonia, ATP, amid groups of proteins and proteins glycation. A conclusion is made that ammonia breaks homeostatic equilibrium of blood, its composition and structural functional properties of hemoglobin.
Hrubinko
V V
VV
Smol's'kyĭ
O S
OS
Iavonenko
O F
OF
D000641:Ammonia / Q000506:poisoning*; D000818:Animals; D001769:Blood / Q000187:drug effects*; D001772:Blood Cell Count / Q000187:drug effects / Q000662:veterinary; D001773:Blood Cells / Q000737:chemistry / Q000187:drug effects*; D002347:Carps / Q000097:blood*; D005393:Fish Diseases / Q000097:blood* / Q000139:chemically induced*; D006454:Hemoglobins / Q000737:chemistry / Q000187:drug effects; D011041:Poisoning / Q000097:blood / Q000662:veterinary
D006454:Hemoglobins; D000641:Ammonia