31P NMR measurements of the effects of unsaturated fatty acids on cellular phospholipid metabolism.
31P NMR measurements on extracts prepared from a variety of cultured mammalian cell lines and primary rat hepatocytes have shown changes in the levels of several phospholipid metabolites after incubation of cells with unsaturated fatty acids. These data suggest a possible link between the accumulation of neutral lipid and the changes in phospholipid metabolite concentrations that have been observed in some tumor cells and other rapidly growing tissues such as the regenerating liver and mitogen-stimulated lymphocytes.
Gillham
H
H
Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Brindle
K M
KM
D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D008099:Liver / Q000166:cytology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D051379:Mice; D010739:Phospholipase D / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D014407:Tumor Cells, Cultured; D010738:Type C Phospholipases / Q000378:metabolism
D005231:Fatty Acids, Unsaturated; D010743:Phospholipids; D010738:Type C Phospholipases; D010739:Phospholipase D