title: Activity of trimethoprim/sulfamethoxazole plus polymyxin B against multiresistant Stenotrophomonas maltophilia.
abstract: The inhibitory activity of eight antibiotics and the inhibitory and bactericidal activities of combinations of trimethoprim/sulfamethoxazole (TMP/SMX) plus three fixed concentrations of polymyxin B (0.01 microgram/ml, 0.1 microgram/ml and 0.5 microgram/ml) against 30 multi-resistant strains of Stenotrophomonas maltophilia were tested. Polymyxin B at 0.01 microgram/ml modified the inhibitory activity of TMP/SMX against only 40% of strains. At 0.1 microgram/ml and 0.5 microgram/ml, polymyxin B enhanced the inhibitory activity of TMP/SMX activity against all strains. Polymyxin B enhanced the bactericidal activity of TMP/SMX only at concentrations near the minimum inhibitory concentration of polymyxin B alone.
authors.affiliation: Department of Microbiology, Hospital Universitario de Salamanca, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Muñoz
authors.forename: M I
authors.initials: MI
authors.lastname: García
authors.forename: S
authors.initials: S
authors.lastname: Muñoz
authors.forename: S
authors.initials: S
authors.lastname: Leal
authors.forename: M
authors.initials: M
authors.lastname: Fajardo
authors.forename: J A
authors.initials: JA
authors.lastname: Garćia-Rodríguez
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D006801:Humans; D008826:Microbial Sensitivity Tests; D011112:Polymyxin B / Q000494:pharmacology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology*; D014974:Xanthomonas / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D011112:Polymyxin B