title: Chemistry and biological activity of a tryptamine and beta-carboline series of bases.
abstract: Twenty-six derivatives of harmaline and tetrahydroharmine were prepared and characterized by UV, IR, MS, and NMR spectroscopy. They were tested for their antimicrobial, antiplatelet aggregation and cytotoxic activity. Their effect on central nervous system was also studied.
authors.affiliation: H.E.J. Research Institute of Chemistry, University of Karachi, Pakistan.
authors.forename: S
authors.initials: S
authors.lastname: Begum
authors.forename: S B
authors.initials: SB
authors.lastname: Usmani
authors.forename: B S
authors.initials: BS
authors.lastname: Siddiqui
authors.forename: S A
authors.initials: SA
authors.lastname: Saeed
authors.forename: S
authors.initials: S
authors.lastname: Farnaz
authors.forename: K A
authors.initials: KA
authors.lastname: Khan
authors.forename: S A
authors.initials: SA
authors.lastname: Khan
authors.forename: S M
authors.initials: SM
authors.lastname: Khalid
authors.forename: A
authors.initials: A
authors.lastname: Zia
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002243:Carbolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002491:Central Nervous System Agents / Q000138:chemical synthesis / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006246:Harmaline / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008826:Microbial Sensitivity Tests; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014363:Tryptamines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D002243:Carbolines; D002491:Central Nervous System Agents; D010975:Platelet Aggregation Inhibitors; D014363:Tryptamines; D006246:Harmaline