title: Actin-based organelle movement.
abstract: Evidence for actin-dependent organelle movement was first obtained from studies of cytoplasmic streaming in plants. These studies, together with cell-free organelle motility studies and biophysical analyses of muscle myosin, support a model whereby organelle-associated motor molecules utilize the energy of adenosine triphosphate binding and hydrolysis to drive movement along F-actin tracks. Recent studies indicate that this mechanism for organelle movement may be responsible for organelle and vesicle movement during secretion, endocytosis and mitochondrial inheritance in a variety of eukaryotes.
authors.affiliation: Department of Anatomy and Cell Biology, Columbia University, New York, New York 10032, USA.
authors.forename: V R
authors.initials: VR
authors.lastname: Simon
authors.forename: L A
authors.initials: LA
authors.lastname: Pon
mesh_terms: D000199:Actins / Q000494:pharmacology; D003595:Cytoplasmic Streaming / Q000502:physiology; D004705:Endocytosis; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism; D008958:Models, Molecular; D015388:Organelles / Q000378:metabolism*; D010944:Plants / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000502:physiology
chemical_list: D000199:Actins