title: Elution characteristics of vancomycin and tobramycin combined in acrylic bone-cement.
abstract: Combining two antibiotics in antibiotic-loaded bone-cement is common in clinical practice. As the effect this has on elution characteristics is unknown, an in vitro quantitative elution study was carried out. Three groups of five antibiotic-loaded cement disks were prepared and placed in individual saline baths for 5 weeks. The elution of tobramycin from the disks in the study group (containing 2.4 g tobramycin and 1.0 g vancomycin per 40-g packet of Palacos-R cement powder [Smith & Nephew Orthopaedics, Memphis, TN]) was increased by 68% over that of the tobramycin control disks (2.4 g tobramycin only) (P = .024). The release of vancomycin from the study group disks was increased by 103% over the vancomycin control disks (1.0 g vancomycin only) (P = .007). Combining two antibiotics in bone-cement improves elution of both antibiotics in vitro and may translate into enhanced elution in vivo.
authors.affiliation: Department of Orthopaedics, University of British Columbia, Vancouver, Canada.
authors.forename: M J
authors.initials: MJ
authors.lastname: Penner
authors.forename: B A
authors.initials: BA
authors.lastname: Masri
authors.forename: C P
authors.initials: CP
authors.lastname: Duncan
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001843:Bone Cements; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D008768:Methylmethacrylates; D014031:Tobramycin / Q000008:administration & dosage*; D014640:Vancomycin / Q000008:administration & dosage*
chemical_list: D000900:Anti-Bacterial Agents; D001843:Bone Cements; D004337:Drug Carriers; D008768:Methylmethacrylates; D014640:Vancomycin; D014031:Tobramycin