title: Acute psychosis associated with abrupt withdrawal of carbamazepine following intoxication.
abstract: Carbamazepine is regularly used in the treatment of trigeminal neuralgia. Although exacerbation of psychosis has been described following abrupt discontinuation of carbamazepine in chronic schizophrenics, a withdrawal syndrome has not been reported previously in patients treated for trigeminal neuralgia. The case presented here suggests that abrupt withdrawal of toxic concentrations of carbamazepine may precipitate a withdrawal reaction, which is manifest some days after discontinuation of the drug. Therefore it may be advisable to withdraw therapy slowly in these situations.
authors.affiliation: Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland.
authors.forename: D
authors.initials: D
authors.lastname: Darbar
authors.forename: A M
authors.initials: AM
authors.lastname: Connachie
authors.forename: A M
authors.initials: AM
authors.lastname: Jones
authors.forename: R W
authors.initials: RW
authors.lastname: Newton
mesh_terms: D000208:Acute Disease; D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects* / Q000627:therapeutic use; D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D011605:Psychoses, Substance-Induced / Q000175:diagnosis*; D013375:Substance Withdrawal Syndrome
chemical_list: D018712:Analgesics, Non-Narcotic; D002220:Carbamazepine