[Determination of acetylation phenotype in the therapeutic monitoring of drugs].
New methods for detecting the acetylation phenotype have been developed for therapeutic monitoring using isoniazid as the pharmacogenetic marker. The study is carried out with 4-chloro-5,7-dinitrobenzofurane by direct spectrophotometry, high performance liquid and thin-layer chromatography. The methods proved to be highly sensitive, selectively detecting isoniazid, simple, and requiring no sophisticated equipment. The methods were tried in examinations of patients with visceral diseases. Effects of various inductors on the acetylation rate were assessed.
Evgen'ev
M I
MI
Garmonov
S Iu
SIu
Pogorel'tsev
V I
VI
Kurtbelialova
Kh I
KhI
Valimukhametova
D A
DA
D000107:Acetylation; D000995:Antitubercular Agents / Q000652:urine; D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D016903:Drug Monitoring; D006801:Humans; D007538:Isoniazid / Q000652:urine; D010597:Pharmacogenetics; D010641:Phenotype; D013053:Spectrophotometry
D000995:Antitubercular Agents; D007538:Isoniazid