title: FISH characterization of the Xq21 breakpoint in a translocation carrier with premature ovarian failure.
abstract: A panel of ordered YAC clones, isolated using STSs in the Xq13-Xq23 region, was used to characterize by Fluorescent In Situ Hybridization (FISH) the Xq21 breakpoint in a t(X;1)(q21;p34) translocation female with premature ovarian failure. The YAC 949E11 was found to span the breakpoint, but also to join the two non-overlapping YACs 36CB1 and 40AB3, proximal and distal, respectively, to the patient's Xq21 breakpoint.
authors.affiliation: Dipartimento di Biologia e Genetica per le Scienze Mediche, Università di Milano, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Riva
authors.forename: I
authors.initials: I
authors.lastname: Magnani
authors.forename: A M
authors.initials: AM
authors.lastname: Fuhrmann Conti
authors.forename: D
authors.initials: D
authors.lastname: Gelli
authors.forename: C
authors.initials: C
authors.lastname: Sala
authors.forename: D
authors.initials: D
authors.lastname: Toniolo
authors.forename: L
authors.initials: L
authors.lastname: Larizza
mesh_terms: D000293:Adolescent; D018244:Chromosomes, Artificial, Yeast / Q000235:genetics; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D015342:DNA Probes; D005260:Female; D006579:Heterozygote; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D016649:Primary Ovarian Insufficiency / Q000235:genetics*; D014178:Translocation, Genetic; D014960:X Chromosome / Q000235:genetics*
chemical_list: D015342:DNA Probes