title: Effects of intravenous immune globulin on the peripheral lymphocyte phenotypes in Kawasaki disease.
abstract: The effect of intravenous immune globulin (IVIG) on the lymphocyte phenotypes in acute Kawasaki disease (KD) was studied in a random trial of IVIG-and-aspirin versus aspirin-alone. Before therapy, patients in each treatment group had an increased percentage of B cells, and a decreased percentage of T cells, CD4 T cells, CD8 T cells and CD5+ B cells. There was no significant difference in immunologic parameters between the two groups measured before therapy. Patients treated with IVIG-and-aspirin had by the fourth day developed a highly-significant increase in T cells, CD4 T cells and CD8 T cells and a decrease in B cells. Despite the decrease of B cells, there were significant increases in CD5+ B cells in both treatment groups. However, the degree of increase in the IVIG-and-aspirin treated group was significantly more noticeable than that in the aspirin-alone treated group. These findings indicate that treatment with IVIG restores the T- and B- cell abnormalities, especially CD5+ B-cell abnormalities found in patients with acute KD.
authors.affiliation: Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: H K
authors.initials: HK
authors.lastname: Lee
authors.forename: D S
authors.initials: DS
authors.lastname: Kim
authors.forename: G W
authors.initials: GW
authors.lastname: Noh
authors.forename: K Y
authors.initials: KY
authors.lastname: Lee
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D016130:Immunophenotyping; D007223:Infant; D016131:Lymphocyte Subsets / Q000276:immunology*; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000276:immunology / Q000628:therapy*
chemical_list: D016756:Immunoglobulins, Intravenous