title: Synthesis of aminothienopyrimidine and thienotriazolopyrimidine derivatives as potential anticonvulsant agents.
abstract: New aminothienopyrimidines and derivatives of the new thienotriazolopyrimidine ring system were synthesized to investigate their anticonvulsant activity. The tricyclic compounds 6a, c, e, f, m, o and p and two bicyclic derivatives 4f and 4o were tested. The pharmacological screening results are reported and discussed.
authors.affiliation: Istituto di Chimica Farmaceutica e Tossicologica, Università di Catania, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Santagati
authors.forename: M
authors.initials: M
authors.lastname: Modica
authors.forename: A
authors.initials: A
authors.lastname: Santagati
authors.forename: F
authors.initials: F
authors.lastname: Russo
authors.forename: S
authors.initials: S
authors.lastname: Spampinato
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D012640:Seizures / Q000517:prevention & control; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D011743:Pyrimidines; D013876:Thiophenes; D014230:Triazoles