title: Simultaneous formation of peptides and nucleotides from N-phosphothreonine.
abstract: An intramolecular mutual activation between a phosphoryl group and carboxyl group results in the simultaneous formation of nucleotides and peptides by the reaction of nucleosides with N-(O,O-diisopropyl)phosphothreonine in anhydrous pyridine. These results suggest pathways for the simultaneous prebiotic synthesis of peptides and oligonucleotides.
authors.affiliation: Bioorganic Phosphorus Chemistry Laboratory, Tsinghua University, Beijing, P.R. China.
authors.forename: W
authors.initials: W
authors.lastname: Zhou
authors.forename: Y
authors.initials: Y
authors.lastname: Ju
authors.forename: Y
authors.initials: Y
authors.lastname: Zhao
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.forename: G
authors.initials: G
authors.lastname: Luo
mesh_terms: D002851:Chromatography, High Pressure Liquid; D019075:Electrophoresis, Capillary; D009705:Nucleosides / Q000737:chemistry; D009711:Nucleotides / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D010769:Phosphothreonine / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D009705:Nucleosides; D009711:Nucleotides; D010455:Peptides; D010769:Phosphothreonine