Levels of glutamic acid decarboxylase (GAD), gamma amino butyric acid transaminase (GABA-T), glutamic acid dehydrogenase (GLDH) and proteins in cerebrospinal fluid of certain neurological disorders.
Important glutamic acid metabolising enzymes in brain namely GAD, GABA-A and GLDH have been studied in the CSF of tuberculous meningitis (TBM), pyogenic meningitis (PM) and brain tumor (BT). The levels of GAD were reported as picomoles of GABA formed/mg of protein/hour. The control levels of the enzymes were GAD = 129 +/- 54, GABA-T = 533 +/- 146 and GLDH...O. 198 +/- 0.097. The levels of GAD were significantly increased (P < 0.001), in both TBM and PM, the values were 302 +/- 81 and, 290 +/- 97 respectively. The GABA-T levels were significantly raised (P < 0.001) only in PM cases 639 +/- 171. The values were reported as nano moles of GABA transformed/mg of protein/hour. The CSF-GLDH levels (unit/litre) showed significant elevation (P +/- 0.001) in TBM in PM, the values were 0.41 +/- 0.1 and 0.41 +/- 0.18 respectively. The CSF proteins were markedly elevated in all the conditions.
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Dept. of Biochemistry, L.T.M. Medical College, L.T.M. General Hospital, Sion, Bombay.
Millimoria
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D000612:4-Aminobutyrate Transaminase / Q000134:cerebrospinal fluid*; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid*; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D005968:Glutamate Decarboxylase / Q000134:cerebrospinal fluid*; D005969:Glutamate Dehydrogenase / Q000134:cerebrospinal fluid*; D006801:Humans; D008581:Meningitis / Q000134:cerebrospinal fluid*
D002556:Cerebrospinal Fluid Proteins; D005969:Glutamate Dehydrogenase; D000612:4-Aminobutyrate Transaminase; D005968:Glutamate Decarboxylase