Antiseptic myramistin possesses the strong anti-HIV properties.
The anti-HIV properties of cation detergent myramistin were studied. The dose-dependent slowing down both of the HIV antigens accumulation in supernatants and the virus-dependent cell death was shown at myramistin concentrations 30 micrograms/ml and 50 micrograms/ml in the MT-4 cell line. Simultaneous addition of the trace amount of the detergents and HIV-1 to the cells of Jurkat-tat line did not stimulate the HIV p24 production for 4 days of the experiment.
Kryvorutchenko
Iu L
IuL
Department of Microbiology, Crimean Medical Institute, Simferopol.
Kryvosheïn
Iu S
IuS
Andronovs'ka
I B
IB
Marennykova
S S
SS
Stepanova
L H
LH
Nosyk
D N
DN
Kalnina
L B
LB
Rud'ko
A P
AP
D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D001548:Benzalkonium Compounds / Q000494:pharmacology*; D003497:Cyclic N-Oxides / Q000494:pharmacology; D003902:Detergents / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D016655:HIV Core Protein p24 / Q000032:analysis / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects* / Q000254:growth & development / Q000276:immunology; D006801:Humans; D019169:Jurkat Cells; D007945:Leukemia, Lymphoid; D014407:Tumor Cells, Cultured; D014776:Virus Cultivation
D000891:Anti-Infective Agents, Local; D000998:Antiviral Agents; D001548:Benzalkonium Compounds; D003497:Cyclic N-Oxides; D003902:Detergents; D016655:HIV Core Protein p24; C066010:desintegron O; C058048:miramistin