Synthesis and pharmacological activity of some N,N-disubstituted 1-amino-2-phenyl-3H,12H-naphtho[1,2-b]pyrano[2,3-d]pyran-3-ones.
The synthesis of some N,N-disubstituted 1-amino-2-phenyl-3H,12H-naphtho[1,2-b]pyrano[2,3-d]pyran-3-ones 4, by reaction of phenylchloroketene with a series of N,N-disubstituted 3-aminomethylene-2,3-dihydro-4H-naphtho[1,2-b]pyran-4-ones, followed by dehydrochlorination in situ of the primary adducts with DBN, is described. Some compounds 4 showed antiarrhythmic and analgesic activities.
Longobardi
M
M
Istituto di Scienze Farmaceutiche dell' Università, Genova, Italy.
Bargagna
A
A
Mariani
E
E
Filippelli
W
W
Falcone
G
G
Marabese
I
I
D000889:Anti-Arrhythmia Agents / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D009284:Naphthols / Q000737:chemistry / Q000494:pharmacology*; D010147:Pain Measurement
D000889:Anti-Arrhythmia Agents; D009284:Naphthols