title: [Postoperative complications of anterior and middle skull base surgery].
abstract: The authors present the postoperative complications of skull base surgery based on a 10-year experience with 26 patients operated on via the supraorbital trans-basal or orbitozygomatic approach. The lesions included 19 malignant tumors and seven benign tumors. Postoperative cerebrospinal (CSF) leak occurred in one of the two patients in whom the dural defects were repaired with a fascia lata graft. None of the remaining 24 patients who were repaired with a musculopericranial flap suffered postoperative CSF leak. Three patients developed epidural abscess, but no infection was seen in the patients who had been reconstructed with a vascularized musculo-cutaneous flap to occlude the dead space. Preoperative radiation therapy correlated with a high incidence of postoperative infection. Cranial nerve deterioration or palsy occurred in four patients. Intraoperative injury of the internal carotid artery occurred in one patient who developed severe neurological deterioration. After an average follow-up period of 40 months (range 12 to 109 months), 68% of patients with malignant tumors and 100% of patients with benign tumors were alive with no evidence of recurrence.
authors.affiliation: Department of Neurosurgery, Kurume University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Tokutomi
authors.forename: M
authors.initials: M
authors.lastname: Shigemori
authors.forename: M
authors.initials: M
authors.lastname: Hirano
authors.forename: S
authors.initials: S
authors.lastname: Sakaguchi
authors.forename: K
authors.initials: K
authors.lastname: Kiyokawa
authors.forename: K
authors.initials: K
authors.lastname: Hayakawa
authors.forename: Y
authors.initials: Y
authors.lastname: Tai
mesh_terms: D000038:Abscess / Q000453:epidemiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D020212:Carotid Artery Injuries; D003389:Cranial Nerve Diseases / Q000453:epidemiology; D004172:Diplopia / Q000453:epidemiology; D004824:Epidural Space; D005260:Female; D006429:Hemiplegia / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D000857:Olfaction Disorders / Q000453:epidemiology*; D011183:Postoperative Complications / Q000453:epidemiology*; D012189:Retrospective Studies; D012888:Skull Neoplasms / Q000601:surgery*; D013122:Spinal Diseases / Q000453:epidemiology*; D013530:Surgical Wound Infection / Q000453:epidemiology