Two autonomous nodules of a patient with multinodular goiter harbor different activating mutations of the thyrotropin receptor gene.
Duprez
L
L
Institut de Recherche Interdisciplinaire, Faculty of Medicine, University of Brussels, Belgium.
Hermans
J
J
Van Sande
J
J
Dumont
J E
JE
Vassart
G
G
Parma
J
J
D000236:Adenoma / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D004247:DNA / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006044:Goiter, Nodular / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D011989:Receptors, Thyrotropin / Q000235:genetics*; D017422:Sequence Analysis, DNA; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology
D011989:Receptors, Thyrotropin; D004247:DNA