p53 Phosphorylation: biochemical and functional consequences.
The p53 protein plays a vital role in suppressing the development of cancer. Posttranslational modification through phosphorylation has been postulated to be an important regulatory mechanism of p53 function. Data describing the role of phosphorylation in terms of its effects on several biochemical properties and cellular functions of p53 are examined in the context of how p53 might be "phospho-regulated."
Milczarek
G J
GJ
Department of Molecular and Cellular Biology, University of Arizona, Life Sciences South, Tucson 85721, USA.
Martinez
J
J
Bowden
G T
GT
D000818:Animals; D002455:Cell Division; D002472:Cell Transformation, Viral; D004247:DNA / Q000378:metabolism; D004261:DNA Replication; D006801:Humans; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D010766:Phosphorylation; D011487:Protein Conformation; D011494:Protein Kinases / Q000378:metabolism; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry / Q000378:metabolism*
D016159:Tumor Suppressor Protein p53; D004247:DNA; D011494:Protein Kinases; D010749:Phosphoprotein Phosphatases