title: Genes, enzymes and secondary metabolites in industrial microorganisms. The 1995 Thom Award Lecture.
abstract: Apparently contrasting approaches, ie genetic engineering and screening of new microorganisms, play essential complementary roles to develop current industrial microbiology. Three topics, production and modification of milk-clotting proteinases by genetic engineering, hormonal control of secondary metabolism in streptomycetes, and screening of bioactive metabolites, are introduced as cases of such a hybrid approach, while symbiotic microorganisms are discussed as an example of the vast terra incognita still remaining for the future microbiology.
authors.affiliation: Department of Applied Biological Science, College of Veterinary Medicine, Nihon University, Kanagawa, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Beppu
mesh_terms: D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000235:genetics / Q000378:metabolism; D002453:Cell Cycle / Q000187:drug effects; D002611:Cheese / Q000382:microbiology; D005818:Genetic Engineering; D006728:Hormones / Q000502:physiology; D007218:Industrial Microbiology / Q000379:methods* / Q000639:trends; D008892:Milk / Q000382:microbiology; D009090:Mucorales / Q000201:enzymology / Q000235:genetics; D013302:Streptomyces / Q000378:metabolism; D013559:Symbiosis
chemical_list: D006728:Hormones; D016282:Aspartic Acid Endopeptidases