Hypotensive and vasorelaxing activities of a lectin from the edible mushroom Tricholoma mongolicum.
A lectin, which exerted a hypotensive action in rats after intravenous injection via the jugular vein, was isolated from the mycelia of the edible mushroom Tricholoma mongolicum. The lectin possessed a molecular weight of 37 K and its hypotensive activity was dose-dependent. Administration of the lectin at a dose of 10 mg/kg body weight caused a mean arterial blood pressure reduction of 95.3 +/- 7.4 mmHg. The lectin's hypotensive action was not mediated via autonomic ganglion transmission, alpha-adrenoceptors, beta-adrenoceptors, cholinergic receptors, histaminergic receptors, nor the renin-angiotensin system, but it was probably mediated through vasorelaxation via adenosine A2 receptors and/or nitric oxide production.
Wang
H X
HX
Department of Biology, Chinese University of Hong Kong, N.T., Hong Kong.
Ooi
V E
VE
Ng
T B
TB
Chiu
K W
KW
Chang
S T
ST
D000241:Adenosine / Q000031:analogs & derivatives / Q000378:metabolism; D019830:Adenosine-5'-(N-ethylcarboxamide); D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D000818:Animals; D001011:Aorta / Q000187:drug effects; D001487:Basidiomycota; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects*; D006325:Heart Atria / Q000187:drug effects; D006386:Hemagglutination Tests; D007022:Hypotension / Q000139:chemically induced / Q000188:drug therapy*; D037102:Lectins / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D008729:Methoxamine / Q000627:therapeutic use*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018047:Receptors, Purinergic P1 / Q000378:metabolism; D014664:Vasodilation
D000316:Adrenergic alpha-Agonists; D037102:Lectins; D018047:Receptors, Purinergic P1; D019830:Adenosine-5'-(N-ethylcarboxamide); D008729:Methoxamine; D000241:Adenosine