In vitro susceptibility of Helicobacter pylori to protolichesterinic acid from the lichen Cetraria islandica.
With reference to the traditional use of Cetraria islandica (Iceland moss) for relief of gastric and duodenal ulcer, plant extracts were screened for in vitro activity against Helicobacter pylori. (+)-Protolichesterinic acid, an aliphatic alpha-methylene-gamma-lactone, was identified as an active component. The MIC range of protolichesterinic acid, in free as well as salt form, was 16 to 64 micrograms/ml.
Ingolfsdottir
K
K
Department of Pharmacy, University of Iceland, Reykjavik, Iceland. kring@rhi.hi.is
Hjalmarsdottir
M A
MA
Sigurdsson
A
A
Gudjonsdottir
G A
GA
Brynjolfsdottir
A
A
Steingrimsson
O
O
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000494:pharmacology; D016480:Helicobacter pylori / Q000187:drug effects*; D008011:Lichens / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology
D010936:Plant Extracts; C095781:protolichesterinic acid; D015107:4-Butyrolactone