title: 1H chemical shift imaging reveals loss of brain tumor choline signal after administration of Gd-contrast.
abstract: 1H MR spectra obtained by chemical shift imaging (CSI) of contrast-enhancing brain tumors before and after the administration of Gd-contrast agent were quantitated and compared with the results in normal brain tissue included in the volume of interest. Twenty-seven combined magnetic resonance imaging and spectroscopy (MRI, MRS) examinations of brain tumor lesions included T1-weighted MRI and CSI (TR/TE 1500/135 ms double-spin echo) repeated 5-10 min after the administration of Gd-contrast agent (0.1-0.2 mM). In 1H MR spectra of contrast-enhancing tumor Gd-contrast induced a mean loss of 15% of the peak area of choline-containing compounds (Cho, P < 0.001) that was correlated with precontrast Cho linewidth (r = -0.72, P < 0.00001). This phenomenon limits the diagnostic use of brain tumor MRS examinations performed immediately after contrast-enhanced MRI.
authors.affiliation: Dr. Daniel den Hoed Cancer Center, Department of Radiology, University Hospital Rotterdam, The Netherlands.
authors.forename: P E
authors.initials: PE
authors.lastname: Sijens
authors.forename: M J
authors.initials: MJ
authors.lastname: van den Bent
authors.forename: P J
authors.initials: PJ
authors.lastname: Nowak
authors.forename: P
authors.initials: P
authors.lastname: van Dijk
authors.forename: M
authors.initials: M
authors.lastname: Oudkerk
mesh_terms: D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D001921:Brain / Q000378:metabolism / Q000473:pathology; D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology; D002794:Choline / Q000032:analysis*; D003287:Contrast Media; D003401:Creatine / Q000032:analysis; D005583:Fourier Analysis; D005682:Gadolinium; D019786:Gadolinium DTPA; D006571:Heterocyclic Compounds; D006801:Humans; D006859:Hydrogen; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D012044:Regression Analysis
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D001224:Aspartic Acid; D004369:Pentetic Acid; D006859:Hydrogen; C000179:N-acetylaspartate; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; D005682:Gadolinium; D019786:Gadolinium DTPA; D003401:Creatine; D002794:Choline