title: [Malignant blue nevus with metastasis to lymph nodes and brain].
abstract: We report a patient who developed malignant transformation of a cellular blue nevus. At the age of 19 years the congenital, pigmented tumor on the left buttock was histopathologically diagnosed as cellular blue nevus. Thirty years later the tumor dramatically increased in size, involving the entire left buttock within several months. Multiple biopsies revealed the presence of a cellular blue nevus within the papillary dermis and an invasive, pleomorphic pigmented sarcoma in the depth of the tissue spreading into subcutis and skeletal muscle. Both benign and malignant cells were S100+, vimentin+ and HMB-45+, but only the malignant tumor cells stained positive for the proliferating cell nuclear antigen. General examination disclosed multiple metastases in the paraaortal lymph nodes and the retroperitoneum as well as a single brain metastasis. Despite palliative therapy with ionizing radiation and chemotherapy, the patient developed generalized metastases and died within weeks. This case clearly confirms that cellular blue nevi have the potential for malignant transformation and that the malignant variant may behave aggressively just as a malignant melanoma.
authors.affiliation: Abteilung für Allgemeine Dermatologie, Universitätsklinik für Dermatologie, Wien.
authors.forename: C
authors.initials: C
authors.lastname: Niederecker
authors.forename: B
authors.initials: B
authors.lastname: Sauter
authors.forename: A M
authors.initials: AM
authors.lastname: Fürnsinn
authors.forename: K
authors.initials: K
authors.lastname: Rappersberger
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000473:pathology / Q000556:secondary*; D002081:Buttocks; D002455:Cell Division / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D018329:Nevus, Blue / Q000151:congenital / Q000473:pathology / Q000556:secondary*; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000151:congenital / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor