title: Dermatofibroma with granular cells.
abstract: A new histologic variant of dermatofibroma, only briefly alluded to in dermatological literature is reported. This tumor was located in the back of a 24-year-old man. It was present for about 2 years and had a history of trauma 2 months before excision. The lesion showed similar characteristics to those of conventional dermatofibroma as well as the presence of groups of granular cells identical to those seen in granular cell tumors. It is important to recognize dermatofibroma with granular cells because it may be confused with a variety of benign or malignant soft tissue tumors containing similar granular cells that entail different significance or prognosis. The immunohistochemical study supports a granular cell change in a dermatofibroma instead of a granular cell tumor that has been traumatized, with secondary formation of a dermatofibroma reaction.
authors.affiliation: Anatomical Pathology Department, Marqués de Valdecilla University Hospital, Medical Faculty, University of Cantabria, Santander, Spain.
authors.forename: J F
authors.initials: JF
authors.lastname: Val-Bernal
authors.forename: C
authors.initials: C
authors.lastname: Mira
mesh_terms: D000328:Adult; D001415:Back / Q000473:pathology*; D003937:Diagnosis, Differential; D018219:Histiocytoma, Benign Fibrous / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*