title: Antithrombin-III activity in plasma of healthy and sick cattle.
abstract: Antithrombin-III (AT-III) activity was determined in the plasma of 32 healthy cows. The range of activities was between 105 and 160 per cent of a human reference plasma; the median activity was 132.5 per cent, and the 5 per cent and the 95 per cent quartiles were 111.1 per cent and 153.9 per cent of the standard. The activity of AT-III was also determined in 82 cows with a variety of internal diseases. In cows with hepatopathy, acute enteritis, generalised peritonitis, blood loss, idiopathic cardiomyopathy, glomerulonephritis and disseminated coagulopathy, the activity of AT-III was lower than in healthy animals. The lower values were due to decreased synthesis, increased consumption, or the loss of AT-III. An acquired deficiency of AT-III appears to favour the development of thrombophlebitis.
authors.affiliation: Department of Internal Veterinary Medicine, School of Veterinary Medicine, University of Zürich, Switzerland.
authors.forename: N
authors.initials: N
authors.lastname: Pusterla
authors.forename: U
authors.initials: U
authors.lastname: Braun
authors.forename: R
authors.initials: R
authors.lastname: Forrer
authors.forename: H
authors.initials: H
authors.lastname: Lutz
mesh_terms: D000818:Animals; D000990:Antithrombin III / Q000378:metabolism*; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood*; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D012015:Reference Standards
chemical_list: D000990:Antithrombin III