Cytologic features of deep juvenile xanthogranuloma.
Juvenile xanthogranuloma (JXG) is a rare lesion of the skin and deep tissues whose cytologic features have not previously been published. We report on 2 cases of JXG in patients aged 5 days and 5 yr who presented with an axillary mass and enlarged supraclavicular lymph node, respectively. Fine-needle aspiration and touch imprints made from the surgical biopsies yielded cellular specimens composed of histiocytes, multinucleated Touton-type giant cells, and variable admixtures of lymphocytes and eosinophils. One lesion was composed primarily of benign-appearing histiocytes with admixed multinucleated giant cells and a few lymphocytes. The second lesion consisted of a few histiocytes, occasional Touton giant cells, many lymphocytes, and scattered fibroblasts. The histiocytes were CD68-positive and S100-negative. Histologic follow-up confirmed the diagnosis of juvenile xanthogranuloma. One patient was lost to follow-up; the other is alive without evidence of recurrence 1 yr after surgery. We conclude that deep JXG has characteristic and diagnostic cytologic features.
Grenko
R T
RT
Department of Pathology, Hershey Medical Center, PA 17033, USA.
Sickel
J Z
JZ
Abendroth
C S
CS
Cilley
R E
RE
D001365:Axilla; D001707:Biopsy, Needle; D002675:Child, Preschool; D003937:Diagnosis, Differential; D006801:Humans; D007231:Infant, Newborn; D008198:Lymph Nodes / Q000473:pathology*; D014972:Xanthogranuloma, Juvenile / Q000175:diagnosis* / Q000473:pathology*