Sparoxomycins A1 and A2, new inducers of the flat reversion of NRK cells transformed by temperature sensitive Rous sarcoma virus. I. Taxonomy of the producing organism, fermentation and biological activity.
Streptomyces sparsogenes SN-2325 isolated from a soil sample collected in Hokkaido, was found to produce sparoxomycins A1 and A2, new modulators of proliferation of mammalian cells. Sparoxomycins A1 and A2 reverse the morphology of temperature-sensitive mutant Rous sarcoma virus-infected NRK cells (src(ts)-NRK cells) from the transformed phenotype to the normal phenotype at the permissive temperature.
Ubukata
M
M
Institute of Physical and Chemical Research (RIKEN), Saitama, Japan.
Morita
T
T
Kakeya
H
H
Kobinata
K
K
Kudo
T
T
Osada
H
H
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology*; D001358:Avian Sarcoma Viruses / Q000187:drug effects; D002478:Cells, Cultured; D005285:Fermentation; D005434:Flow Cytometry; D008826:Microbial Sensitivity Tests; D011744:Pyrimidinones / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D013302:Streptomyces
D000903:Antibiotics, Antineoplastic; D011744:Pyrimidinones; C098364:sparoxomycin A1