[Immunomodulating and hepatoprotective action of retinoids in toxic liver involvement induced by D-galactosamine].
The experiments on Wistar rats showed that beta-carotene and retinol acetate decreased the level of the biochemical signs of the hepatocyte injury and lowered or abolished the immunosuppressive effect induced by D-galactosamine. The hepatoprotective and immunomodulating effects of beta-carotene were higher. D-Galactosamine induced the development of the immunosuppressing properties in light erythrocytes and retinol acetate induced the development of the immunostimulating properties in heavy erythrocyte of the poisoned animals. beta-carotene prevented the development of the immunosuppressing properties in such cells. The immunomodulating effect of beta-carotene in the toxic affection of the liver was associated with blocking or retarding of the entry of the suppressing substances to the vascular channel from the hepatocytes and did not depend on their action on the erythrocytes.
Konoplia
E N
EN
Konoplia
N A
NA
Prokopenko
L G
LG
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000975:Antioxidants / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D004912:Erythrocytes / Q000187:drug effects / Q000276:immunology; D005688:Galactosamine; D007166:Immunosuppressive Agents; D015227:Lipid Peroxidation / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012756:Sheep; D013237:Stereoisomerism; D014801:Vitamin A / Q000627:therapeutic use*; D019207:beta Carotene / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D000975:Antioxidants; D007166:Immunosuppressive Agents; D019207:beta Carotene; D014801:Vitamin A; D005688:Galactosamine