Increased mutagen-induced chromosome damage in patients with transformed laryngeal pre-cancerosis.
Factors that contribute to malignant transformation of laryngeal pre-neoplastic lesions remain largely unknown. Potential etiological factors may be related to a genetically controlled sensitivity to environmental carcinogens. In this study, we investigated bleomycin-induced chromosome damage in 15 patients who experienced a malignant transformation of preneoplastic laryngeal lesions during follow-up, as compared with chromosome fragility in 30 historical controls with no progression of keratoses during a 10-year follow-up, in a match-paired analysis. Chromosomal analysis demonstrated higher sensitivity to clastogens in patients with malignant progression of laryngeal pre-neoplastic lesions than that of control patients with no evolution of their original laryngeal keratoses (p = 0.003). Furthermore, among the study patients, chromosome sensitivity was most apparent in non-tobacco users with malignant transformation of laryngeal disease. Our data suggest that subjects with pre-neoplastic laryngeal lesion showing increased susceptibility to carcinogens could be at higher risk for development of laryngeal carcinoma.
Gallo
O
O
Institute of Otolaryngology-Head-and-Neck Surgery, University of Florence, Italy.
Santoro
R
R
Lenzi
S
S
Boddi
V
V
Giovannucci-Uzielli
M L
ML
D000328:Adult; D000368:Aged; D001761:Bleomycin / Q000633:toxicity*; D016022:Case-Control Studies; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations / Q000235:genetics*; D003582:Cytogenetics; D005260:Female; D006801:Humans; D007818:Laryngeal Diseases / Q000235:genetics* / Q000473:pathology; D007822:Laryngeal Neoplasms / Q000209:etiology*; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009153:Mutagens / Q000633:toxicity; D011230:Precancerous Conditions / Q000235:genetics* / Q000473:pathology; D012907:Smoking
D009153:Mutagens; D001761:Bleomycin