title: Effect of educational level, gender and age on the performance in a multi-user computerized psychometric test system for use in clinical pharmacological studies.
abstract: 197 native, drug-free healthy young volunteers performed psychometric tests on a single occasion, using a new multi-user computerized test system which consists of tests of simple reaction time, complex reaction time, vigilance, concentration, motor coordination, short-term memory (word pairs or figures) and abstract language-free reasoning (2 versions). Normality of distribution of all psychometric variables was checked. For the reasoning tests and the memory tests, internal consistency and parallel test reliability were determined. Cross-correlations between the variables and factor analysis were done to evaluate whether different tests measure different brain functions. Multivariate variance analysis was carried out to test the effect of the independent factors school education, gender and age on the performance in the psychometric tests. Subjects with a lower school education level performed worse in the reasoning tests, the concentration test and the memory tests. Females were slower in the coordination test and made fewer correct solutions in the concentration test. Older subjects performed worse in the reasoning tests and had a longer working time in the memory tests than younger ones. The results show the necessity of psychometric screening of volunteers before recruitment for clinical pharmacological psychometric studies in order to reduce-individual variability.
authors.affiliation: Bayer AG, Institute of Clinical Pharmacology, Pharma Research Center, Wuppertal, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Versavel
authors.forename: D
authors.initials: D
authors.lastname: van Laack
authors.forename: C
authors.initials: C
authors.lastname: Evertz
authors.forename: F
authors.initials: F
authors.lastname: Meier
authors.forename: J
authors.initials: J
authors.lastname: Kuhlmann
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001143:Arousal / Q000187:drug effects; D001288:Attention / Q000187:drug effects; D001334:Automobile Driving / Q000523:psychology; D003201:Computers; D004493:Education; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects; D008606:Mental Processes / Q000187:drug effects; D009048:Motor Skills / Q000187:drug effects; D010601:Pharmacology, Clinical / Q000295:instrumentation / Q000592:standards*; D011594:Psychometrics / Q000592:standards*; D011930:Reaction Time / Q000187:drug effects; D012016:Reference Values; D012737:Sex Factors