title: Maltophilin: a new antifungal compound produced by Stenotrophomonas maltophilia R3089.
abstract: Strains of Stenotrophomonas maltophilia R3089, isolated from the rhizosphere of rape plants (Brassica napus L.), produced a novel antifungal compound, named maltophilin, which inhibited the growth of various saprophytic, human-pathogenic and phytopathogenic fungi but was inactive against Gram-positive and Gram-negative bacteria. Maltophilin is a novel macrocyclic lactam antibiotic with a molecular mass of 510 mu. The compound was isolated from the culture filtrate by ethyl acetate extraction and gel filtration on Sephadex LH20 and purified by preparative HPLC on reversed phase. The structure of maltophilin was elucidated by electrospray mass spectrometry and 1H and 13C NMR spectroscopy.
authors.affiliation: Universität Tübingen, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Jakobi
authors.forename: G
authors.initials: G
authors.lastname: Winkelmann
authors.forename: D
authors.initials: D
authors.lastname: Kaiser
authors.forename: C
authors.initials: C
authors.lastname: Kempler
authors.forename: G
authors.initials: G
authors.lastname: Jung
authors.forename: G
authors.initials: G
authors.lastname: Berg
authors.forename: H
authors.initials: H
authors.lastname: Bahl
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D007769:Lactams; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007769:Lactams; C103159:maltophilin