[Disturbance of regional blood flow and activity of lipid peroxidation in recurrent ulcer and their drug correction].
Regional blood flow and intensity of free-radical lipid peroxidation were evaluated at rheogastrography and biochemically (quantitation of malonic dialdehyde and antioxidant serum activity), respectively, in 25 patients with recurrent ulcer. Recurrent ulcer is shown to induce disturbances in gastric wall regional hemodynamics due to activated vascular tone, reduced arterial blood inflow and venostasis. Lipid peroxidation became overactive and decreased defence potentialities of gastroduodenal serum. Oleum Hippopheae which is a natural antioxidant, improves regional hemodynamics by relaxation of overstrained vessels, stimulation of arterial blood inflow and relief of venous congestion. Overactive lipid peroxidation declines, antioxidant activity of the serum improves, especially in gastric ulcer, ulcer defect repair runs more actively.
Tsimmerman
I S
IS
Department of Faculty Therapy, Medical Institute, Perm.
Mikhailovskaia
L V
LV
D000293:Adolescent; D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers; D001783:Blood Flow Velocity; D016145:Endoscopy, Digestive System; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010437:Peptic Ulcer / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D012008:Recurrence
D000897:Anti-Ulcer Agents; D000975:Antioxidants; D015415:Biomarkers; D008315:Malondialdehyde