title: Synthesis of isomelamines and isocyanurates and their biological evaluation.
abstract: The reaction of cyanogen bromide (1) with primary amines (2a-p), including arylmethylamines (2l-p), gave the corresponding cyanamides (3a-p). Trimerization of 3a-p gave 1,3,5-trisubstituted 2,4,6-triiminohexahydro-1,3,5-triazines (isomelamines) (4a-p), which were treated with hydrochloric acid to give the corresponding 1,3,5-trisubstituted 2,4,6-trioxohexahydro-1,3,5-triazines (isocyanurates) (5a-c, f) and 1,3,5-trisubstituted 2-imino-4,6-dioxohexahydro-1,3,5-triazines (5b'-e'). Biological evaluation of 4a-p, 5a-c,f, and 5b'-e' was carried out, and some of these compounds showed bronchodilator and positive inotropic activities.
authors.affiliation: Institute for Life Support Technology, Yamagata Technopolis Foundation, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Niwa
authors.forename: H
authors.initials: H
authors.lastname: Kamada
authors.forename: E
authors.initials: E
authors.lastname: Shitara
authors.forename: J
authors.initials: J
authors.lastname: Horiuchi
authors.forename: N
authors.initials: N
authors.lastname: Kibushi
authors.forename: T
authors.initials: T
authors.lastname: Kato
mesh_terms: D000818:Animals; D001993:Bronchodilator Agents / Q000737:chemistry; D003484:Cyanamide / Q000737:chemistry* / Q000494:pharmacology; D003488:Cyanogen Bromide; D006168:Guinea Pigs; D009119:Muscle Contraction; D013268:Stimulation, Chemical; D014227:Triazines / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D001993:Bronchodilator Agents; D014227:Triazines; D003484:Cyanamide; C011907:melamine; D003488:Cyanogen Bromide