title: Apparently increased trough levels of tacrolimus caused by acute infantile diarrhea in two infants with biliary atresia after liver transplantation.
abstract: Two infants with biliary atresia who exhibited three-fold increased trough levels of tacrolimus and required reduced doses during episodes of acute infantile diarrhea within 5 months of liver transplantation are described. The cause of the increase was not explained simply by hemoconcentration as a result of significant loss of extracellular fluid during these episodes. It does highlight an important issue: that of the continuing need to carefully monitor the trough levels of tacrolimus in such infants.
authors.affiliation: Department of Paediatrics, Jichi Medical School, Tochigi, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Matsui
authors.forename: Y
authors.initials: Y
authors.lastname: Arakawa
authors.forename: T
authors.initials: T
authors.lastname: Momoya
authors.forename: N
authors.initials: N
authors.lastname: Sasaki
authors.forename: S
authors.initials: S
authors.lastname: Kawasaki
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000208:Acute Disease; D001656:Biliary Atresia / Q000378:metabolism*; D003968:Diarrhea, Infantile / Q000378:metabolism*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood / Q000493:pharmacokinetics*; D007223:Infant; D007565:Jaundice / Q000601:surgery; D016031:Liver Transplantation; D011171:Portoenterostomy, Hepatic; D016559:Tacrolimus / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus