Induction of DnaK and GroEL heat shock proteins by fluoroquinolones in Escherichia coli.
Various fluoroquinolones (norfloxacin, enoxacin, ofloxacin, levofloxacin, and sparfloxacin) induce DnaK and GroEL heat shock proteins in Escherichia coli. The induction is transient, consistent with the kinetics of cellular DNA relaxation. The concentrations of fluoroquinolones required for induction are similar to those required for DNA relaxation and much higher than those required for cell death.
Mizushima
T
T
Department of Microbiology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Matsuo
M
M
Sekimizu
K
K
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000096:biosynthesis*; D018834:Chaperonin 60 / Q000096:biosynthesis*; D004269:DNA, Bacterial / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000378:metabolism*; D029968:Escherichia coli Proteins; D024841:Fluoroquinolones; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis*
D000890:Anti-Infective Agents; D001426:Bacterial Proteins; D018834:Chaperonin 60; D004269:DNA, Bacterial; D029968:Escherichia coli Proteins; D024841:Fluoroquinolones; D018840:HSP70 Heat-Shock Proteins; C063842:dnaK protein, E coli