title: ICAM-1 expression in corneal epithelium of a patient with vernal keratoconjunctivitis: case report.
abstract: Recent reports have demonstrated the expression of intercellular adhesion molecule-1 (ICAM-1; CD54) on the epithelium in various allergic diseases and inflammatory conditions, including the bronchial epithelium of patients with allergic asthma, conjunctival epithelium of allergic patients after allergen-specific challenge, and corneal epithelium of rejected corneal allografts. We investigated the presence of ICAM-1 expression on the corneal epithelium from a patient with vernal keratoconjunctivitis (VKC). Immunohistochemical staining of the diseased cornea demonstrated abundant ICAM-1 expression on the corneal epithelium. Immunoreactive ICAM-1 appeared to localize primarily to the cells of the basal and middle layers of the corneal epithelium. No staining was detected on the ocular surface epithelium. The normal, healthy cornea demonstrated no significant ICAM-1 expression on any of the epithelial layers, similar to that previously reported. To the best of our knowledge, this is the first report of ICAM-1 expression on the corneal epithelium from a patient with VKC.
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, School of Medicine, Galveston 77555-0787, USA.
authors.forename: K S
authors.initials: KS
authors.lastname: Gill
authors.forename: J
authors.initials: J
authors.lastname: Yannariello-Brown
authors.forename: J
authors.initials: J
authors.lastname: Patel
authors.forename: N
authors.initials: N
authors.lastname: Nakajima
authors.forename: S
authors.initials: S
authors.lastname: Rajaraman
authors.forename: S D
authors.initials: SD
authors.lastname: Trocmé
mesh_terms: D000328:Adult; D001665:Binding Sites; D003233:Conjunctivitis, Allergic / Q000378:metabolism* / Q000473:pathology; D003315:Cornea / Q000378:metabolism* / Q000473:pathology; D004848:Epithelium / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D008297:Male; D010375:Pedigree
chemical_list: D018799:Intercellular Adhesion Molecule-1