Metastasis to the liver in well-differentiated carcinoma of the thyroid.
Eleven patients (6 women; 5 men) of a series of 1,916 developed liver metastasis from differentiated thyroid cancer within 3 months to 202 months after the initial diagnosis. Liver metastasis generally appeared after the onset of metastases at other sites. The metastasis to the liver was clinically suspected in 8 patients whereas it was accidentally diagnosed on ultrasound examination of abdomen for a complaint of back pain in 1 patient, on a whole body diagnostic radioiodine scan in 1 case, and on radionuclide liver scan in 1 patient. Three patients had noniodide concentrating hepatic metastasis which were treated with chemotherapy but with poor response. The remaining 8 patients were treated with radioiodine. The survival rate was poor but could not be attributed to liver metastasis per se because of the extensive metastatic disease at other sites.
Shah
D H
DH
Radiation Medicine Centre (BARC), Tata Memorial Centre (Annexe), Parel, Bombay, India.
Samuel
A M
AM
D018263:Adenocarcinoma, Follicular / Q000473:pathology / Q000556:secondary; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002291:Carcinoma, Papillary / Q000473:pathology / Q000556:secondary; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery
D000970:Antineoplastic Agents; D007457:Iodine Radioisotopes