Functional alpha 1-adrenergic receptors on leukocytes of patients with polyarticular juvenile rheumatoid arthritis.
During the last decade it has been shown that the central nervous system can influence the immune system. In healthy individuals, catecholamines can inhibit the production of pro-inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) via interaction with beta 2-adrenergic receptors. In contrast, we show here that catecholamines can stimulate the production of the interleukin-6 (IL-6) in children with the chronic inflammatory disease polyarticular juvenile rheumatoid arthritis (JRA). The induction of IL-6 is mediated by triggering of alpha 1-adrenergic receptors on peripheral blood leucocytes of the patients with polyarticular JRA. Functional alpha 1-adrenergic receptors are absent on leukocytes of normal donors and on leukocytes of patients with the oligoarticular form of the disease.
Heijnen
C J
CJ
Department of Immunology, University Hospital for Children and Youth Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands.
Rouppe van der Voort
C
C
Wulffraat
N
N
van der Net
J
J
Kuis
W
W
Kavelaars
A
A
D000293:Adolescent; D001171:Arthritis, Juvenile / Q000503:physiopathology*; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D017292:Doxazosin / Q000494:pharmacology; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000502:physiology*; D008297:Male; D010656:Phenylephrine / Q000494:pharmacology; D018340:Receptors, Adrenergic, alpha-1 / Q000502:physiology*
D015850:Interleukin-6; D018340:Receptors, Adrenergic, alpha-1; D010656:Phenylephrine; D017292:Doxazosin