title: Structure-function analysis of the cloned opiate receptors: peptide and small molecule interactions.
abstract: Opiate receptors mediate the physiological actions of opioid peptides and the clinical effects of the synthetic opioid agonists and antagonists. Site-directed mutagenesis studies have revealed regions of opiate receptors that are essential for ligand recognition, and this could aid the design of more selective opioid ligands.
authors.affiliation: Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
authors.forename: A D
authors.initials: AD
authors.lastname: Blake
authors.forename: G
authors.initials: G
authors.lastname: Bot
authors.forename: T
authors.initials: T
authors.lastname: Reisine
mesh_terms: D001665:Binding Sites; D003001:Cloning, Molecular; D008958:Models, Molecular; D015394:Molecular Structure; D009292:Narcotic Antagonists; D010455:Peptides / Q000378:metabolism*; D011957:Receptors, Opioid / Q000819:agonists / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D009292:Narcotic Antagonists; D010455:Peptides; D011957:Receptors, Opioid