title: Characterization of alpha 2-adrenoceptor subtypes in the porcine eye: identification of alpha 2A-adrenoceptors in the choroid, ciliary body and iris, and alpha 2A- and alpha 2C-adrenoceptors in the retina.
abstract: The subtypes of alpha 2-adrenoceptor were characterized in the choroid, ciliary body, iris and retina of the pig eye by using radioligand binding. [3H]-MK912 labelled dense populations of alpha 2A-adrenoceptors in the choroid and ciliary body. In the retina, [3H]-MK912 labelled both alpha 2A- and alpha 2C-adrenoceptors. In the iris, receptors of the alpha 2A-adrenoceptor type were detected by using either [3H]-MK912 or [3H]-RX821002 as radioligands.
authors.affiliation: Department of Ophthalmology, Academic Hospital, Uppsala, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Wikberg-Matsson
authors.forename: J E
authors.initials: JE
authors.lastname: Wikberg
authors.forename: S
authors.initials: S
authors.lastname: Uhlén
mesh_terms: D000818:Animals; D002829:Choroid / Q000737:chemistry; D002924:Ciliary Body / Q000737:chemistry; D005123:Eye / Q000737:chemistry*; D007498:Iris / Q000737:chemistry; D011869:Radioligand Assay; D018341:Receptors, Adrenergic, alpha-2 / Q000032:analysis*; D012160:Retina / Q000737:chemistry; D013552:Swine / Q000378:metabolism*
chemical_list: D018341:Receptors, Adrenergic, alpha-2