[Comparative investigation of anticonvulsive effects of putrescine and structural analogues of delta-sleep-inducing peptide].
Intracysternal putrescine before a session of hyperbaric oxygenation (0.7 MPa) was shown to be more effective in prolonging the latent period of onset of generalized convulsive activity than intraperitoneal delta-sleep-inducing peptide or its structural analogues ID-1 or ID-3. Biochemical studies indicated that putrescine was also more effective in preventing hyperbaric oxygenation-induced decreases in the levels of GABA and homocarnosine in the brain and the accumulation of lipid peroxidation products in the brain and serum.
Uskova
N I
NI
NII of Neurocybernetics of AV Kogan, Rostov-Na-Donu.
Lysenko
A V
AV
Mendzheritskii
A M
AM
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002336:Carnosine / Q000031:analogs & derivatives / Q000378:metabolism; D003701:Delta Sleep-Inducing Peptide / Q000031:analogs & derivatives / Q000494:pharmacology*; D006931:Hyperbaric Oxygenation; D015227:Lipid Peroxidation; D008297:Male; D011700:Putrescine / Q000494:pharmacology*; D051381:Rats; D012640:Seizures / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
C005038:homocarnosine; D005680:gamma-Aminobutyric Acid; D003701:Delta Sleep-Inducing Peptide; D002336:Carnosine; D011700:Putrescine