Mapping of 10 novel microsatellites in the MHC class III region: application to the study of autoimmune disease.
The MHC class III region contains many genes that are good candidates for involvement in autoimmune disease. We report the mapping and characterization of 10 novel (CA)n microsatellites spanning the region, which are highly informative and suitable for linkage and association studies. We used these markers to identify haplotypes of MHC class III microsatellite alleles in DNA from cell lines homozygous for MHC class II and class I alleles.
Hsieh
S L
SL
Department of Biochemistry, Oxford University, UK.
March
R E
RE
Khanna
A
A
Cross
S J
SJ
Campbell
R D
RD
D001327:Autoimmune Diseases / Q000235:genetics; D002874:Chromosome Mapping; D004268:DNA-Binding Proteins / Q000235:genetics*; D044365:GTP-Binding Protein alpha Subunits, G12-G13; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics; D018895:Microsatellite Repeats / Q000235:genetics*
D004268:DNA-Binding Proteins; D044365:GTP-Binding Protein alpha Subunits, G12-G13