title: The immune response to islets in experimental diabetes and insulin-dependent diabetes mellitus.
abstract: Over the past year, a number of important observations have been made in the nonobese diabetic mouse and in clinical insulin-dependent diabetes mellitus concerning the autoimmune response to islets. Assays have advanced to the point where individuals at risk for insulin-dependent diabetes mellitus can be readily identified prior to the onset of symptoms and a number of peptides of proteins expressed by the beta cell have been shown to protect nonobese diabetic mice from developing diabetes. The contributions of CD4+ and CD8+ T cells to beta cell destruction are beginning to be understood and this information will probably be of value in the design of intervention strategies for use in human subjects.
authors.affiliation: Barbara Davis Center for Childhood Diabetes, University of Colorado, Denver 80262, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Wegmann
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology*