[Interrelationship between pro-oxidant and immunomodulating properties of vitamin D].
It was shown in experiments on mice that 1.25 (OH)2D3 ingested per os in dose 100 ng during 5 days caused the great increasing of lipid peroxidation (LP) in peritoneal macrophages and spleen cells. The evidence of LP induction is the production of TBA-positive substances in these cells. Linear negative dependence was found between increasing of LP and functional activity of lymphocytes which was evidenced by blast transformation of lymphocytes under effect of concanavalin or mitogen of laconose. Linear positive correlation was shown between level of LP and function of macrophages.
Pletsityĭ
K D
KD
Davydova
T V
TV
Fomina
V G
VG
Nikushkin
E V
EV
Kucherianu
V G
VG
Iurasov
V V
VV
D000284:Administration, Oral; D000818:Animals; D002117:Calcitriol / Q000008:administration & dosage / Q000494:pharmacology*; D016014:Linear Models; D015227:Lipid Peroxidation / Q000187:drug effects; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects; D017737:Macrophages, Peritoneal / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000166:cytology / Q000378:metabolism
D002117:Calcitriol