title: SPECT imaging with 111In-octreotide for the localization of pancreatic insulinoma.
abstract: We evaluated the sensitivity of 111In-Octreotide scintigraphy in the diagnosis of pancreatic insulinoma in a selected number of patients. In addition, we compared the results of scintigraphy with those of other conventional diagnostic techniques. Seven patients with surgically confirmed insulinoma (< 1.5 cm in diameter) of the pancreas were studied. Before surgery, patients underwent arteriography with Ca-gluconate, CT scan, and 111In-Octreotide scintigraphy. 111In-Octreotide scintigraphy showed a higher diagnostic specificity (85%) than selective arteriography (83%) or CT scan (57%). We conclude that 111In-Octreotide scintigraphy should always be performed before surgery in cases of pancreatic insulinoma and that a SPECT acquisition should be performed both 6 and 24 hours post-injection in order to increase the diagnostic sensitivity of the test.
authors.affiliation: Special Service of Nuclear Medicine, II Medical Clinic, University La Sapienza, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Signore
authors.forename: E
authors.initials: E
authors.lastname: Procaccini
authors.forename: M
authors.initials: M
authors.lastname: Chianelli
authors.forename: G
authors.initials: G
authors.lastname: Salerno
authors.forename: P
authors.initials: P
authors.lastname: Iozzo
authors.forename: A
authors.initials: A
authors.lastname: Annovazzi
authors.forename: F
authors.initials: F
authors.lastname: Leonetti
authors.forename: G
authors.initials: G
authors.lastname: Tamburrano
authors.forename: G
authors.initials: G
authors.lastname: Ronga
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000792:Angiography; D002125:Calcium Gluconate; D003952:Diagnostic Imaging; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D007340:Insulinoma / Q000000981:diagnostic imaging* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000031:analogs & derivatives*; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D007205:Indium Radioisotopes; D019275:Radiopharmaceuticals; C094279:indium-111-octreotide; D015282:Octreotide; D002125:Calcium Gluconate