Pharmacologically active components of a Peruvian medicinal plant, huanarpo (Jatropha cilliata).
From Jatropha cilliata M. Arg., a Peruvian medicinal plant, isoorientin and orientin were isolated as anxiolytic components by using the isolation guide of anti-conflict effect in mice. Several related flavonoids were also tested for this effect. Another bioassay-guided isolation using the acetic acid-induced writhing method gave a coumarin compound, fraxetin, as an analgesic principle.
Okuyama
E
E
Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Okamoto
Y
Y
Yamazaki
M
M
Satake
M
M
D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D003220:Conflict, Psychological; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D008815:Mice, Inbred Strains; D010568:Peru; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
D000700:Analgesics; D018712:Analgesics, Non-Narcotic; D014151:Anti-Anxiety Agents; D003975:Diazepam