title: Early magnetic resonance imaging and histologic findings in a model of femoral head necrosis.
abstract: The authors examined early magnetic resonance images and histologic findings of avascular necrosis of the femoral head in a canine model. The avascular necrosis of the femoral head model was surgically induced. Animals were euthanized at 3 days, 1, 2, and 4 weeks, and the proximal femurs were retrieved. Magnetic resonance images and histologic sections were performed on each of the specimens obtained. Twenty-five mongrel dogs were studied, 4 dogs at 3 days and 7 dogs at each of the other intervals. Findings suggest that histologic changes may be seen as early as 3 days, with marrow edema and hemorrhage as early findings, and fibrous marrow transformation and appositional bone growth as later findings. Magnetic resonance imaging abnormalities did not occur until 1 week after injury and were seen in all animals by 4 weeks.
authors.affiliation: Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Ishikawa, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Nishino
authors.forename: K
authors.initials: K
authors.lastname: Tomita
authors.forename: M
authors.initials: M
authors.lastname: Kadoya
mesh_terms: D000818:Animals; D004285:Dogs; D005271:Femur Head Necrosis / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008854:Microscopy, Electron; D055728:Primary Myelofibrosis / Q000473:pathology; D013997:Time Factors