Model of a thalamocortical neurone with dendritic voltage-gated ion channels.
To investigate the functional role of dendrites of thalamocortical neurones, we have used our one-compartmental model to construct a multi-compartmental model with dendritic regions chosen according to a representative soma-to-dendritic terminal path of an X cell of the cat dorsal lateral geniculate nucleus. The multi-compartmental model with dendritic low-threshold Ca2+ and delayed rectifier K+ channels yields more accurate results than the one-compartmental model when simulating tonic firing and oscillatory activities, and provides a useful means for the study of propagation of excitation on the dendrites.
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Physiology Unit, School of Molecular and Medical Biosciences, University of Wales Cardiff, UK.
Emri
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Tóth
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Crunelli
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D000818:Animals; D002415:Cats; D003712:Dendrites / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology*; D008959:Models, Neurological; D013788:Thalamus / Q000502:physiology*
D007473:Ion Channels