Sulthiame-associated mild compensated metabolic acidosis.
Sulthiame is effectively used in the treatment of benign and symptomatic focal epilepsy in children. Hyperventilation as a symptom is a well known adverse effect of the drug. Alterations of the acid-base equilibrium have been described for the drug, however, very infrequently only in adults without a detailed evaluation of the disorders status. The case presented here demonstrates a mild compensated metabolic acidosis in a child which, for the first time, is described using the methods of complete blood gas and electrolytes analysis.
Tröger
U
U
Department of Clinical Pharmacology, Hospital of the Otto-von-Guericke-University, Magdeburg, Germany.
Fritzsch
C
C
Darius
J
J
Gedschold
J
J
Meyer
F P
FP
D000138:Acidosis / Q000097:blood / Q000139:chemically induced*; D000927:Anticonvulsants / Q000009:adverse effects*; D001784:Blood Gas Analysis; D002675:Child, Preschool; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy; D006801:Humans; D008297:Male; D013843:Thiazines / Q000009:adverse effects*; D000096926:Benzenesulfonamides
D000927:Anticonvulsants; D013843:Thiazines; C084593:sulthiame; D000096926:Benzenesulfonamides