title: Diagnostic accuracy of hysteroscopy in endometrial hyperplasia.
abstract: OBJECTIVE
  To determine the diagnostic accuracy of hysteroscopy in the diagnosis of endometrial hyperplasia in women with abnormal uterine bleeding.
  
  
  METHODS
  From 1993 through 1995, 980 women referred to our institution for abnormal uterine bleeding underwent diagnostic hysteroscopy with eye direct biopsy of the endometrium in case of macroscopic abnormalities. Hysteroscopic features were compared with pathologic findings in order to detect the reliability of the endoscopic procedure. Statistical analysis was performed with the McNemar test.
  
  
  RESULTS
  Positive predictive value of hysteroscopy in the diagnosis of endometrial hyperplasia accounted for 63%. In fact hysteroscopic diagnosis of endometrial hyperplasia was confirmed at pathologic examination in 81 out of 128 patients. Sensitivity and specificity of the endoscopic procedure accounted for 98% and 95%, respectively. Negative predictive value accounted for 99%, as only two cases of atypical hyperplasia were missed at hysteroscopy. Positive predictive value was higher in postmenopausal patients compared to women in the fertile age (72 vs. 58%).
  
  
  CONCLUSIONS
  Overall, results appear encouraging, since no case of endometrial hyperplasia was missed by hysteroscopy. The high diagnostic accuracy, associated with a minimal trauma, renders hysteroscopy the ideal procedure for both diagnosis and follow-up of conservative management of endometrial hyperplasia.
authors.affiliation: Department of Obstetrics and Gynecology, University of Bari, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Loverro
authors.forename: S
authors.initials: S
authors.lastname: Bettocchi
authors.forename: G
authors.initials: G
authors.lastname: Cormio
authors.forename: V
authors.initials: V
authors.lastname: Nicolardi
authors.forename: M R
authors.initials: MR
authors.lastname: Porreca
authors.forename: N
authors.initials: N
authors.lastname: Pansini
authors.forename: L
authors.initials: L
authors.lastname: Selvaggi
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D003937:Diagnosis, Differential; D004714:Endometrial Hyperplasia / Q000175:diagnosis* / Q000473:pathology; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D008875:Middle Aged; D012680:Sensitivity and Specificity; D014592:Uterine Hemorrhage / Q000209:etiology* / Q000473:pathology