title: Neurodevelopmental outcome of extremely low birth weight infants in Maryland.
abstract: The survival rate of extremely low birth weight (ELBW; i.e. < 1001 grams) infants has significantly improved in the past 10 years secondary to the numerous advances in neonatology. There have been many favorable reports of the neurodevelopmental outcomes of survivors, but the studies often span several years to collect sufficient number of subjects. This study assesses the outcome of 100 ELBW infants born in Maryland in 1990 and analyzes factors that may have contributed to their outcomes at one year corrected age. Of this group, 72% had no evidence of severe disability (e.g., cerebral palsy (CP) or mental retardation (MR); however, 51% of the children had abnormal or suspect neurological examinations, and 24% had CP. Eighteen percent of the children were more than one standard deviation below the mean cognitively; 30% were below normal for motor abilities, and 33% were below normal for language abilities. Prior to this study, many of these children were not recognized by their primary physician as having any developmental problems. Many of these children were not followed in neonatal intensive care unit (NICU) follow-up programs, and most were not receiving appropriate early intervention services (EIS). Previous studies have associated different neonatal events with the risk of developmental delay. Bronchopulmonary dysplasia (BPD) and periventricular leukomalacia (PVL) accounted for most of the variance of this sample's developmental outcome. Of these 100 ELBW infants, 56 received surfactant. Analysis demonstrated no significant differences in developmental outcomes between those who received surfactant and those who did not. However, those who received rescue surfactant were more likely to acquire a diagnosis of BPD. As demonstrated by this study, ELBW infants are at risk for significant developmental problems. This supports the need for targeted outreach, developmental monitoring, early intervention services, and parent support and education.
authors.affiliation: Developmental Pediatric Associates, Scottsdale, Arizona, USA.
authors.forename: R K
authors.initials: RK
authors.lastname: Blitz
authors.forename: R C
authors.initials: RC
authors.lastname: Wachtel
authors.forename: L
authors.initials: L
authors.lastname: Blackmon
authors.forename: J
authors.initials: J
authors.lastname: Berenson-Howard
mesh_terms: D016009:Chi-Square Distribution; D002657:Child Development; D002658:Developmental Disabilities / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008297:Male; D008396:Maryland / Q000453:epidemiology; D011663:Pulmonary Surfactants / Q000627:therapeutic use; D012044:Regression Analysis; D015996:Survival Rate
chemical_list: D011663:Pulmonary Surfactants