[Liver function in patients exposed to a toluene in a hydrocarbon processing plant].
Since the hepatotoxic role of toluene in exposed workers from the petroleum and petrochemical industries chronically exposed to low concentration has no been entirely dilucidated, this transversal study was undertaken in order to clarify the situation in the local industries. A group of 33 non-exposed men workers of such industries (group control, aged 33.0 +/- 4.88 years) were compared with 33 toluene-exposed men (aged 35.0 +/- 9.33 years) from the related industries, with a minimal of 6 months exposition time to toluene and without liver disease history. In addition to a complete occupational diseases medical history, each subject was tested by both a venous blood sample (to determine prothrombin, total and fractioned bilirubin, total and fractioned proteins, liver enzymes and cholesterol) and urine sample (hippuric acid). Also the environmental concentration of toluene in working areas was determined by gas chromatography, which was below the recommended standard levels in working areas. Although the analyzed parameters were in the normal range, it was observed that those workers with known alcohol ingestion and toluene exposition had several abnormalities. The results of this study confirm that toluene may have a synergistic hepatotoxic effect in toluene-exposed workers that are alcohol consumers. The alcohol in considered as a confounding factor and it is not possible to rule out in the etiology of hepatic changes detected in the study.
Sánchez
E
E
Instituto de Medicina del Trabajo e Higiene Industrial, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela.
Fernández-D'Pool
J
J
D000328:Adult; D001663:Bilirubin / Q000032:analysis; D018592:Cross-Over Studies; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008111:Liver Function Tests; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects*; D011516:Prothrombin / Q000032:analysis; D014050:Toluene / Q000009:adverse effects*
D014050:Toluene; D011516:Prothrombin; D001663:Bilirubin