Inhibitory effect of dietary wheat bran on formation of aberrant crypt foci in rat colon induced by a single injection of 1,2-dimethylhydrazine.
The frequency of appearance of aberrant crypt foci (ACF) in the distal colon was significantly lower in rats fed a high fiber (20% wheat bran) diet than in those fed a fiber-free one at 4 weeks after a single injection of 1,2-dimethylhydrazine (DMH, 20 mg/kg), although crypt/ACF was high in the former relative to the latter. This result suggests that dietary wheat bran effectively serves as a regulator of ACF frequency at early stages after DMH injection.
Ishizuka
S
S
Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo, Japan.
Kasai
T
T
D019813:1,2-Dimethylhydrazine; D000818:Animals; D003108:Colonic Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D004043:Dietary Fiber; D004127:Dimethylhydrazines; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014908:Triticum / Q000737:chemistry*
D004043:Dietary Fiber; D004127:Dimethylhydrazines; D019813:1,2-Dimethylhydrazine