[Chorioretinal lymphoproliferative disorder induced by Epstein-Barr virus in lung transplantation].
The Epstein-Barr virus (EBV) is the causative factor of the posttransplant lymphoproliferative syndromes. Some ocular cases were described. We report the case of a lung-transplanted 59 year old man who presented a chorioretinal lymphoproliferative syndrome. A B-cell monoclonality and numerous EBV genome copies were demonstrated in vitreous material by PCR. We suspect an intermediate stage between polyclonal lymphoproliferative syndrome and malignant lymphoma. A treatment with nucleoside analogs and immunosuppression decrease was successful. The positive clinical evolution was associated with a reduction of the EBV genome quantity.
Demols
P
P
Service d'Ophtalmologie, Hôpital Erasme, Université Libre de Bruxelles.
Caspers-Velu
L
L
Velu
T
T
Verougstraete
C
C
Zanen
A
A
D002825:Chorioretinitis / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016040:Lung Transplantation / Q000276:immunology*; D008232:Lymphoproliferative Disorders / Q000821:virology*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction
D007166:Immunosuppressive Agents