title: The influence of carbohydrates and polyhydric alcohols on the stability of ceftazidime in aqueous solution.
abstract: The kinetics of degradation of ceftazidime in aqueous solutions containing various carbohydrates (glucose and fructose) or polyhydric alcohols (sorbitol and mannitol) was investigated over the pH range 9.92-10.93 at 35 degrees C. A relationship between the degradation rate and the hydroxy compound concentration was observed at each pH studied, and the rate-accelerating effect of the compounds was directly proportional to the hydroxide ion activity.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, School of Medicine, Poznań, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Zajac
authors.forename: J
authors.initials: J
authors.lastname: Siwek
mesh_terms: D002241:Carbohydrates / Q000494:pharmacology; D002442:Ceftazidime / Q000737:chemistry*; D002511:Cephalosporins / Q000737:chemistry*; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D008353:Mannitol / Q000494:pharmacology; D012996:Solutions; D013012:Sorbitol / Q000494:pharmacology
chemical_list: D002241:Carbohydrates; D002511:Cephalosporins; D012996:Solutions; D008353:Mannitol; D013012:Sorbitol; D002442:Ceftazidime