Apparently increased trough levels of tacrolimus caused by acute infantile diarrhea in two infants with biliary atresia after liver transplantation.
Two infants with biliary atresia who exhibited three-fold increased trough levels of tacrolimus and required reduced doses during episodes of acute infantile diarrhea within 5 months of liver transplantation are described. The cause of the increase was not explained simply by hemoconcentration as a result of significant loss of extracellular fluid during these episodes. It does highlight an important issue: that of the continuing need to carefully monitor the trough levels of tacrolimus in such infants.
Matsui
A
A
Department of Paediatrics, Jichi Medical School, Tochigi, Japan.
Arakawa
Y
Y
Momoya
T
T
Sasaki
N
N
Kawasaki
S
S
Tanaka
K
K
D000208:Acute Disease; D001656:Biliary Atresia / Q000378:metabolism*; D003968:Diarrhea, Infantile / Q000378:metabolism*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood / Q000493:pharmacokinetics*; D007223:Infant; D007565:Jaundice / Q000601:surgery; D016031:Liver Transplantation; D011171:Portoenterostomy, Hepatic; D016559:Tacrolimus / Q000097:blood / Q000493:pharmacokinetics*
D007166:Immunosuppressive Agents; D016559:Tacrolimus