title: Changes in autonomic function with age: a study of pupillary kinetics in healthy young and old people.
abstract: The object of the study was to compare resting pupil diameter in darkness and light, and the pupillary darkness and light reflexes between a group of young and elderly healthy subjects. Twelve young (eight men, four women; median age 19.5 years) and 14 elderly subjects (six men, eight women; median age 69 years) participated. Pupil diameter was monitored with an infra-red television pupillometer. Resting pupil size was measured in light (16 and 32 Cd m-2) and in darkness. The darkness reflex was elicited by switching off the ambient illumination (16 Cd m-2) for 1 s. The light reflex was elicited in darkness by short (200 ms) pulses of green (peak wavelength 565 nm) light at four ascending stimulus intensities (8.5 x 10(-3), 7.0 x 10(-2), 0.43 and 1.84 mW cm-2). The amplitude (mm) and maximum velocity (mm s-1) of the darkness reflex and the latency (ms), amplitude (mm), maximum constriction velocity (mm s-1) and 75% recovery time (s) of the light reflex were measured. The resting pupil diameter was found to be smaller in the elderly group at all three illumination levels (p = 0.001). The amplitude and maximum dilatation velocity of the darkness reflex were smaller for the elderly group (p = 0.001). The amplitude of the light reflex at the three highest light intensities and maximum constriction velocity at all light intensities were smaller in the elderly group (p = 0.002). Seventy-five per cent recovery time was longer in the elderly group (p = 0.02). There was no difference in the latency of the light reflex response between the two groups. The reduced pupil size, diminished darkness reflex amplitude and velocity, and prolonged recovery time of light reflex are consistent with sympathetic deficit in old age. Although the reductions in light reflex amplitude and constriction velocity in the elderly group at first sight would indicate a parasympathetic deficit in old age, they are more likely to be secondary to the grossly diminished pupil size.
authors.affiliation: Department of Psychiatry, University of Nottingham, Queen's Medical Centre.
authors.forename: P
authors.initials: P
authors.lastname: Bitsios
authors.forename: R
authors.initials: R
authors.lastname: Prettyman
authors.forename: E
authors.initials: E
authors.lastname: Szabadi
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001341:Autonomic Nervous System / Q000502:physiology*; D003623:Dark Adaptation / Q000502:physiology; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D008875:Middle Aged; D011674:Pulse / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values; D012025:Reflex, Pupillary / Q000502:physiology