title: [Russian recombinant vaccine against hepatitis B (results of controlled trials)].
abstract: Two yeast recombinant vaccines were compared: the Russian hepatitis B Combiotech vaccine in a dose of 20 mg and the Recombivax-HB vaccine in a dose of 10 mg manufactured in the USA (Merk, Sharp and Dohme Ltd.). Both agents were found safe and low reactogenic. After a course of 3 vaccinations with the Russian vaccine 92.5 to 97.5% subjects vaccinated after the 0-1-2 months and 0-1-6 months protocols had high levels of specific antibodies. In the group vaccinated with the American vaccine, antibodies to HBsAg were found in the sera of 95 to 100% subjects. These results demonstrate high immunological activity of both Russian and American vaccines.
authors.forename: L I
authors.initials: LI
authors.lastname: Pavlova
authors.forename: M A
authors.initials: MA
authors.lastname: Gorbunov
authors.forename: V N
authors.initials: VN
authors.lastname: Borisova
authors.forename: I V
authors.initials: IV
authors.lastname: Krasil'nikov
authors.forename: A V
authors.initials: AV
authors.lastname: Noskova
authors.forename: B N
authors.initials: BN
authors.lastname: Lytsar'
authors.forename: S V
authors.initials: SV
authors.lastname: Skvortsov
authors.forename: E A
authors.initials: EA
authors.lastname: Beliakova
authors.forename: I M
authors.initials: IM
authors.lastname: Iakovleva
authors.forename: Iu P
authors.initials: IuP
authors.lastname: Korovin
authors.forename: A V
authors.initials: AV
authors.lastname: Bel'chenko
authors.forename: I A
authors.initials: IA
authors.lastname: Titov
authors.forename: M V
authors.initials: MV
authors.lastname: Budanov
mesh_terms: D000328:Adult; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control*; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D017325:Hepatitis B Vaccines / Q000627:therapeutic use*; D006801:Humans; D014614:Vaccines, Synthetic / Q000627:therapeutic use*
chemical_list: D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic