Angiotensin I-converting enzyme inhibitors in autolysates of squid liver and mantle muscle.
Autolysis of squid liver and mantle muscle homogenates, and blends of both, each yielded inhibitory activity toward the angiotensin I-converting enzyme. The inhibitory activity and the amount of solubilized protein in each of these autolysates were examined over a period of 24 h. Inhibitory peptides were isolated from the mixed autolysate, their structures (IC50) being Tyr-Ala-Leu-Pro-His-Ala (9.8 microM) and Gly-Tyr-Ala-Leu-Pro-His-Ala (27.3 microM).
Wako
Y
Y
Laboratory of Food Technology, Hachinohe Institute of Technology, Aomori, Japan.
Ishikawa
S
S
Muramoto
K
K
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000302:isolation & purification*; D000818:Animals; D001329:Autolysis; D049832:Decapodiformes / Q000737:chemistry*; D008099:Liver / Q000737:chemistry*; D009132:Muscles / Q000737:chemistry*
D000806:Angiotensin-Converting Enzyme Inhibitors