The neurochemistry of Alzheimer's disease.
The last 15-20 years have seen a wealth of studies to characterize the neurochemical abnormalities of Alzheimer's disease, in particular those involving the beta-amyloid and tau proteins, as well as more recently, apolipoprotein E4. This article provides a summary of the evidence for the involvement of these proteins in Alzheimer's disease pathogenesis based on postmortem brain and CSF studies.
Blennow
K
K
Department of Clinical Neuroscience, University of Göteborg, Mölndal Hospital, Sweden.
Cowburn
R F
RF
D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D016564:Amyloid beta-Protein Precursor / Q000032:analysis*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000032:analysis*; D001921:Brain / Q000473:pathology*; D006801:Humans; D008565:Membrane Proteins / Q000032:analysis*; D016874:Neurofibrillary Tangles / Q000473:pathology*; D053764:Presenilin-1; D016875:tau Proteins / Q000032:analysis*
D016564:Amyloid beta-Protein Precursor; D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D008565:Membrane Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1; D016875:tau Proteins