Potential carcinogenicity of the synthetic 1,3,6-triazine (6-aza) nucleic acid analogues determined by DC polarography. I. Nucleobases.
The polarographic reduction of several synthetic 1,3,6-triazine (6-aza) nucleobases in the strictly anhydrous solution was studied in the absence and presence of alpha-lipoic acid. The values of the half-wave potentials E1/2 and the parameter of potential carcinogenicity tg alpha were determined for one natural and 5 synthetic nucleobases. The current value of the first diffuse polarographic wave or a new diffuse polarographic wave belonging to the nucleobase-alpha-lipoic acid complex increased with the increased alpha-lipoic acid concentration for the all compounds only marginally. Although this diffuse current increase was linearly depended on the alpha-lipoic acid concentration in anhydrous solutions, the determined index tg alpha values ranging between 0.029 and 0.108 indicated a very low potential carcinogenicity of the all nucleobases investigated.
Novotný
L
L
Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovakia.
Vachálková
A
A
Pískala
A
A
Petrásová
R
R
Blesová
B
B
D001372:Aza Compounds / Q000633:toxicity*; D001380:Azauridine / Q000031:analogs & derivatives / Q000633:toxicity; D015197:Carcinogenicity Tests; D010084:Oxidation-Reduction; D013941:Thymine / Q000031:analogs & derivatives*; D014529:Uridine / Q000031:analogs & derivatives*
D001372:Aza Compounds; D001380:Azauridine; D013941:Thymine; D014529:Uridine