Triterpenoid saponins from Aster lingulatus.
Two new triterpenoid saponins named asterlingulatosides A and B were isolated from the whole plants of Aster lingulatus. Their structures were determined by spectroscopic data and chemical transformations to be 3-O-beta-D-glucopyranosyl-3 beta,16 alpha-dihydroxyolean-12-en-28-oic acid-28-O-alpha-L-O-arabinopyranoside and 3-O-beta-D-glucopyranosyl-3 beta,16 alpha-dihydroxyolean-12-en-28-oic acid-28-O-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside++ +. They showed inhibitory activity on DNA synthesis in human leukaemia HL-60 cells.
Shao
Y
Y
Department of Plant Science, Cook College, Rutgers, State University of New Jersey, New Brunswick 08903, USA.
Ho
C T
CT
Chin
C K
CK
Rosen
R T
RT
Hu
B
B
Qin
G W
GW
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000633:toxicity; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D004261:DNA Replication / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D010936:Plant Extracts; D010944:Plants; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D013936:Thymidine / Q000378:metabolism; D014315:Triterpenes / Q000737:chemistry* / Q000633:toxicity
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C104099:asterlingulatoside A; C104100:asterlingulatoside B; D009828:Oleanolic Acid; D013936:Thymidine