Quasiperiodicity and chaos in cardiac fibrillation.
In cardiac fibrillation, disorganized waves of electrical activity meander through the heart, and coherent contractile function is lost. We studied fibrillation in three stationary forms: in human chronic atrial fibrillation, in a stabilized form of canine ventricular fibrillation, and in fibrillation-like activity in thin sheets of canine and human ventricular tissue in vitro. We also created a computer model of fibrillation. In all four studies, evidence indicated that fibrillation arose through a quasiperiodic stage of period and amplitude modulation, thus exemplifying the "quasiperiodic transition to chaos" first suggested by Ruelle and Takens. This suggests that fibrillation is a form of spatio-temporal chaos, a finding that implies new therapeutic approaches.
Garfinkel
A
A
Department of Medicine (Cardiology), University of California, Los Angeles School of Medicine, 90095, USA. alang@lifesci.ucla.edu
Chen
P S
PS
Walter
D O
DO
Karagueuzian
H S
HS
Kogan
B
B
Evans
S J
SJ
Karpoukhin
M
M
Hwang
C
C
Uchida
T
T
Gotoh
M
M
Nwasokwa
O
O
Sager
P
P
Weiss
J N
JN
D000200:Action Potentials; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology*; D001281:Atrial Fibrillation / Q000209:etiology; D003198:Computer Simulation; D018450:Disease Progression; D004285:Dogs; D006801:Humans; D066298:In Vitro Techniques; D008954:Models, Biological; D017711:Nonlinear Dynamics; D010507:Periodicity; D013610:Tachycardia; D014693:Ventricular Fibrillation / Q000209:etiology