title: Circadian rhythm, sleep, and epilepsy.
abstract: This review article: (1) describes the circadian distribution of ictal and interictal events; (2) differentiates transitional arousal, non-rapid eye movement and rapid eye movement sleep components and their substrates; (3) suggests the means by which the neural generators of these seizure-prone vs. seizure-resistant sleep and arousal states modulate the timing of different seizure manifestations; (4) considers clinical and mechanistic findings for the reciprocal effects of seizures and antiepileptic drugs upon the sleep-wake cycle; and (5) assesses clinical and basic mechanisms of sleep deprivation effects upon seizures.
authors.affiliation: Sleep Disturbance Research, VAMC, Sepulveda, California, USA.
authors.forename: M N
authors.initials: MN
authors.lastname: Shouse
authors.forename: A M
authors.initials: AM
authors.lastname: da Silva
authors.forename: M
authors.initials: M
authors.lastname: Sammaritano
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use; D001143:Arousal / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D001931:Brain Mapping; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology*; D004569:Electroencephalography / Q000187:drug effects; D004827:Epilepsy / Q000188:drug therapy / Q000503:physiopathology*; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D006801:Humans; D012892:Sleep Deprivation / Q000502:physiology; D012893:Sleep Wake Disorders / Q000188:drug therapy / Q000503:physiopathology*; D012895:Sleep, REM / Q000187:drug effects / Q000502:physiology
chemical_list: D000927:Anticonvulsants