title: Red blood cell adhesion on a solid/liquid interface.
abstract: Red blood cells (RBCs), previously fixed with glutaraldehyde, adhere to glass slides coated with fibrinogen. The RBC deposition process on the horizontal glass surface is investigated by analyzing the relative surface covered by the RBCs, as well as the variance of this surface coverage, as a function of the concentration of particles. This study is performed by optical microscopy and image analysis. A model, derived from the classical random sequential adsorption model, has been developed to account for the experimental results. This model highlights the strong influence of the hydrodynamic interactions during the deposition process.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, Unité 424, Fédération de Recherche Odontologique, Université Louis Pasteur, Strasbourg, France.
authors.forename: P
authors.initials: P
authors.lastname: Lavalle
authors.forename: J F
authors.initials: JF
authors.lastname: Stoltz
authors.forename: B
authors.initials: B
authors.lastname: Senger
authors.forename: J C
authors.initials: JC
authors.lastname: Voegel
authors.forename: P
authors.initials: P
authors.lastname: Schaaf
mesh_terms: D000327:Adsorption; D002448:Cell Adhesion; D004912:Erythrocytes / Q000502:physiology* / Q000648:ultrastructure; D005340:Fibrinogen; D005898:Glass; D005976:Glutaral; D006801:Humans; D008433:Mathematics; D008855:Microscopy, Electron, Scanning; D008954:Models, Biological; D013499:Surface Properties
chemical_list: D005340:Fibrinogen; D005976:Glutaral