4-Aryl-1-piperazinylalkyl derivatives of 1,2,3,4-tetrahydro-beta-carboline ring system. Synthesis and preliminary in vivo studies.
Three series of compounds containing a 4-aryl-1-piperazinylalkyl fragment attached to a different position of the indole (A) or 1,2,3,4-tetrahydro-beta-carboline (B, C) have been prepared. The quantitative relationship between the structure of some derivatives and their sedative effect was found using the Free-Wilson approach.
Cegła
M T
MT
Department of Organic Chemistry, Collegium Medicum, Jagiellonian University, Kraków, Poland.
Boksa
J
J
Chojnacka-Wójcik
E
E
Misztal
S
S
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002243:Carbolines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D003198:Computer Simulation; D003500:Cyclization; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
D002243:Carbolines; D006993:Hypnotics and Sedatives; D010879:Piperazines