Cirrhotic glomerulonephritis: an underdiagnosed condition.
Glomerular pathology in liver cirrhosis is common in autopsies but is underdiagnosed antemortem. The most common pathologic findings are mesangial disease with immunoglobulin A deposits, and membranoproliferative glomerulonephritis. The latter is associated, most frequently, with hepatitis C infection and cryoglobulinemia. We describe a patient with longstanding liver cirrhosis who presented with a nephritic and nephrotic syndrome. Membranoproliferative glomerulonephritis was diagnosed on kidney biopsy. There was no clinical, laboratory or histologic evidence of hepatitis C infection or cryoglobulinemia. The different aspects of "cirrhotic glomerulonephritis" are discussed and the need for searching for this underdiagnosed condition in patients with chronic liver disease is emphasized.
Ori
Y
Y
Department of Nephrology, Rabin Medical Center, Petah Tikva, Israel.
Korzets
A
A
Sandbank
J
J
Lurie
B
B
Zeidman
A
A
Gafter
U
U
D001706:Biopsy; D015432:Glomerulonephritis, Membranoproliferative / Q000209:etiology* / Q000473:pathology* / Q000628:therapy; D006440:Hemofiltration; D006504:Hepatic Veno-Occlusive Disease / Q000150:complications; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology* / Q000628:therapy