title: The polymorphism of GSTM1, mutagen sensitivity in colon cancer and healthy control.
abstract: The aim of this article is to study the relationship between GSTM1 polymorphism and colon cancer and to compare the chromosomal breakage induced by mutagen in a colon cancer group and healthy controls. Using PCR to identify the GSTM1 genotype, we found the frequency of GSTM1- in colon cancer (n = 19) and control group (n = 23) was 36.8% and 26.1%, respectively (p > 0.05, chi 2-test). The bleomycin-induced chromosomal breakage (break/cell) in the patient group was 0.75 +/- 0.29, and in the control group 0.42 +/- (0.24) (p < 0.05, t-test). The percentage of mutagen sensitivity (b/c > 0.8) in the patient group (68%) was 4 times as high as that in the control group (20%). The mutagen hypersensitivity (b/c > 1.0) in the patient group (47%) was 5 times as high as that in the control group (12%). The odds radio was 6.6.
authors.affiliation: Research Unit of Genotoxicology, School of Public Health, Sun-Yat-Sen University of Medical Sciences, Guangzhou, China.
authors.forename: J Y
authors.initials: JY
authors.lastname: Guo
authors.forename: D S
authors.initials: DS
authors.lastname: Wan
authors.forename: R P
authors.initials: RP
authors.lastname: Zeng
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D001761:Bleomycin / Q000494:pharmacology; D002681:China; D002869:Chromosome Aberrations; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000453:epidemiology* / Q000235:genetics*; D004249:DNA Damage / Q000187:drug effects / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D005260:Female; D017353:Gene Deletion; D005787:Gene Frequency; D005982:Glutathione Transferase / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009153:Mutagens / Q000494:pharmacology*; D011110:Polymorphism, Genetic
chemical_list: D000903:Antibiotics, Antineoplastic; D009153:Mutagens; D001761:Bleomycin; D005982:Glutathione Transferase