Osteochondroma after total body irradiation in bone marrow transplant recipients: report of two cases.
We present two cases of osteochondroma after total body irradiation in bone marrow recipients, the first in a 6-year-old boy with juvenile chronic myelogenous leukemia and the second in a 13-year-old boy with acute myelogenous leukemia. The patients developed multiple osteochondromas three years and seven years, respectively, after 12 Gy of total body irradiation. Neither had a family history of hereditary multiple osteochondromatosis. A review of the English literature revealed only one report describing five cases of osteochondroma after 12 Gy of total body irradiation in bone marrow transplant recipients. Osteochondroma should be considered as an additional adverse effect of total body irradiation.
Maeda
G
G
Department of Orthopedic Surgery, National Cancer Center Hospital, Tokyo.
Yokoyama
R
R
Ohtomo
K
K
Takayama
J
J
Beppu
Y
Y
Fukuma
H
H
Ohira
M
M
D000293:Adolescent; D016026:Bone Marrow Transplantation; D001859:Bone Neoplasms / Q000209:etiology*; D002648:Child; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D015831:Osteochondroma / Q000209:etiology*; D011879:Radiotherapy Dosage; D019172:Transplantation Conditioning; D014916:Whole-Body Irradiation / Q000009:adverse effects*