[Transplacental transmission of the causative agent in experimental rickettsial infection].
It was shown in the experiments on the model of typhus infection in guinea-pigs that the pathogenic organism can be inherited by foetus from the mother's organism in the period of acute infection. It is confirmed by the presence of positive seroconversion in 86% of born offsprings and the character of the immunity response after the control infection that is the initial formation of immunoglobulins of form G (Ig G). At the same time there was no such a transfer of pathogenic organisms in 14% of offsprings. This fact is testified by the absence of seroconversion and the initial formation of immunoglobulins of form M (Ig M) with following formation of immunoglobulins of form G (Ig G) after control infection rickettsia Prowazekii.
Kurganova
I I
II
Klimchuk
N D
ND
D000208:Acute Disease; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000918:Antibody Specificity; D005260:Female; D006168:Guinea Pigs; D007136:Immunoglobulins / Q000097:blood; D010920:Placenta / Q000382:microbiology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology / Q000382:microbiology; D012283:Rickettsia prowazekii / Q000276:immunology; D013997:Time Factors; D014438:Typhus, Epidemic Louse-Borne / Q000276:immunology / Q000382:microbiology / Q000635:transmission*
D000907:Antibodies, Bacterial; D007136:Immunoglobulins