Tempace and troxyl-novel synthesized 2,2,6,6-tetramethylpiperidine derivatives as antioxidants and radioprotectors.
Two novel 2,2,6,6-tetramethylpiperidine derivatives (Tempace and Troxyl) were synthesized and their capacity to act as scavengers of superoxide, inhibitors of iron and ascorbate-driven Fenton reaction and radioprotectors was tested. The possibility for one-electron oxidation of novel compounds by heme-ferryl species was also examined. The results clearly indicate that Tempace and Troxyl are acting as promising antioxidants and radioprotectors thus providing a base for further investigations and pharmacological applications.
Metodiewa
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Institute of Applied Radiation Chemistry, Technical University of Lódź, Poland.
Skolimowski
J
J
Karolczak
S
S
D000975:Antioxidants / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D003037:Cobalt Radioisotopes; D003497:Cyclic N-Oxides / Q000138:chemical synthesis / Q000494:pharmacology*; D003855:Deoxyribose / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D006861:Hydrogen Peroxide; D017665:Hydroxyl Radical / Q000378:metabolism; D007501:Iron; D010084:Oxidation-Reduction; D010880:Piperidines / Q000138:chemical synthesis / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D013113:Spin Labels; D013482:Superoxide Dismutase; D013481:Superoxides / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D019820:Xanthine; D014969:Xanthine Oxidase / Q000378:metabolism; D014970:Xanthines / Q000378:metabolism
D000975:Antioxidants; D003037:Cobalt Radioisotopes; D003497:Cyclic N-Oxides; C045076:Fenton's reagent; D016166:Free Radical Scavengers; D010880:Piperidines; D011837:Radiation-Protective Agents; D013113:Spin Labels; D017392:Thiobarbituric Acid Reactive Substances; D014970:Xanthines; C104521:troxyl; D013481:Superoxides; C104520:tempace; D019820:Xanthine; D017665:Hydroxyl Radical; D003855:Deoxyribose; D006861:Hydrogen Peroxide; D007501:Iron; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; C001803:tempol