title: Prenatal lesioning of vestibular organ by aminoglycosides.
abstract: The effects of gentamicin administrated to gravid mice on the vestibular hair cells of their offspring were investigated. Scanning electron microscopy showed the effect to be dose-dependent and age-dependent, and there was a different sensitivity to toxicity for each of the three types of vestibular receptors. The destructive action of gentamicin on the vestibule before birth provides a mechanism to study the influence of the vestibular system on the central nervous system throughout its development.
authors.affiliation: Centre de Recherche Cerveau et Cognition, Unité Mixte de Recherche 5549 (CNRS, EHESS, UPS), Toulouse, France.
authors.forename: O
authors.initials: O
authors.lastname: Deguine
authors.forename: C
authors.initials: C
authors.lastname: Chappert
authors.forename: C
authors.initials: C
authors.lastname: Fonta
authors.forename: M
authors.initials: M
authors.lastname: Imbert
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005839:Gentamicins / Q000494:pharmacology*; D018069:Hair Cells, Vestibular / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D011247:Pregnancy
chemical_list: D000617:Aminoglycosides; D005839:Gentamicins