title: [A case of malignant neuroleptic syndrome. Case report].
abstract: We report on a woman patient with organophosphate poisoning resulting from a psychotically motivated suicide attempt. After detoxification and during treatment with haloperidol and levomepromazine, she developed acute malignant neuroleptic syndrome (MNS) in which dyspnea requiring assisted ventilation was the main symptom. Discontinuation of the neuroleptics was enough to effect sufficient recovery. With this case report, we would first like to emphasize that MNS can evolve within a very short time into a severe and life-threatening situation requiring intensive medical care, and secondly to illustrate the implications of organophosphate poisoning and the consequent cholinesterase blocking far the differential diagnosis of MNS.
authors.affiliation: Psychiatrische Abteilung, Technischen Universität, Klinikum Rechts der Isar, München.
authors.forename: P
authors.initials: P
authors.lastname: Martius
authors.forename: R
authors.initials: R
authors.lastname: Hüther
authors.forename: T
authors.initials: T
authors.lastname: Zilker
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003422:Critical Care; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D062787:Drug Overdose / Q000523:psychology; D004359:Drug Therapy, Combination; D005260:Female; D006220:Haloperidol / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007306:Insecticides / Q000506:poisoning; D008728:Methotrimeprazine / Q000009:adverse effects* / Q000627:therapeutic use; D009459:Neuroleptic Malignant Syndrome / Q000175:diagnosis*; D009460:Neurologic Examination / Q000187:drug effects; D009946:Organothiophosphorus Compounds / Q000506:poisoning; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000523:psychology; D013406:Suicide, Attempted / Q000523:psychology
chemical_list: D014150:Antipsychotic Agents; D007306:Insecticides; D009946:Organothiophosphorus Compounds; D008728:Methotrimeprazine; C026086:methyl demeton; D006220:Haloperidol