title: Adrenal metastases from renal cell carcinoma: role of ipsilateral adrenalectomy and definition of stage.
abstract: OBJECTIVE
  We undertook this study to establish criteria for adrenalectomy in patients with renal cell carcinoma.
  
  
  METHODS
  We retrospectively reviewed the records of 162 patients undergoing radical nephrectomy from 1979 to 1993 at University Hospitals of Cleveland. Simultaneous ipsilateral adrenalectomy was performed in 57 patients (35%).
  
  
  RESULTS
  Three of these 57 patients (5.3%) had ipsilateral adrenal metastases. All 3 patients had large, left-sided, upper-pole tumors that extended through the renal capsule (Stage T3a). All 3 patients with adrenal metastases had progression to disseminated disease, with an average time to progression of 7.2 months, whereas only 13 (24%) of the 54 patients without adrenal metastases developed metastatic disease (none to adrenal), with an average time to progression of 27.6 months. No patient with organ-confined disease (Stage T1 or T2) or extracapsular disease in the midkidney or lower pole had adrenal metastases identified histologically.
  
  
  CONCLUSIONS
  The prognosis is poor for renal cell carcinoma with ipsilateral adrenal involvement, even with complete removal. Because of this poor prognosis, we believe that adrenal involvement should constitute a separate stage category. We propose that patients with ipsilateral adrenal metastases via direct extension should be classified as having pathologic Stage pT3d. If the patient has an ipsilateral adrenal metastasis not via direct extension, contralateral adrenal metastasis, or bilateral adrenal metastases, the pathologic stage should be M1. Ipsilateral adrenalectomy should only be performed if a lesion is seen preoperatively on computed tomographic scan or if gross disease is seen at the time of nephrectomy although its removal may not benefit the patient.
authors.affiliation: Department of Urology, Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Sandock
authors.forename: A D
authors.initials: AD
authors.lastname: Seftel
authors.forename: M I
authors.initials: MI
authors.lastname: Resnick
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000473:pathology / Q000556:secondary* / Q000601:surgery*; D000315:Adrenalectomy / Q000379:methods; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000556:secondary* / Q000601:surgery*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D009367:Neoplasm Staging; D009392:Nephrectomy; D012189:Retrospective Studies