Leucocyte binding to the uterine epithelial cell surface during lectin-induced decidualization.
Intra-uterine injection of the lectin Concanavalin A (ConA) on day 5 of pseudopregnancy induced a rapid and persistent infiltration of leucocytes into the rat uterine stroma. Although the infiltration of leucocytes was seen along the entire length of the uterine horn, areas of stromal oedema, indicative of decidualization (as indicated by a positive Pontamine Sky Blue reaction), were only associated with regions in which leucocytes had crossed the uterine epithelium and were present in the uterine lumen. Ultrastructural evaluation of the interaction of the luminal leucocytes with the apical surface of the uterine epithelium appeared strikingly similar to that of the blastocyst and the uterine epithelium during normal implantation. It is proposed that leucocytes, induced by ConA, may initiate a decidual response in a manner analogous to that of the blastocyst through surface epithelial interaction.
Shaw
T J
TJ
Department of Anatomy and Histology, University of Sydney, NSW, Australia.
Murphy
C R
CR
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002454:Cell Differentiation; D002634:Chemotaxis, Leukocyte; D003208:Concanavalin A / Q000494:pharmacology*; D003238:Connective Tissue / Q000276:immunology; D003656:Decidua / Q000276:immunology*; D004717:Endometrium / Q000187:drug effects / Q000276:immunology*; D004848:Epithelium / Q000187:drug effects / Q000276:immunology; D005260:Female; D007962:Leukocytes / Q000276:immunology*; D010812:Physical Stimulation; D011555:Pseudopregnancy / Q000209:etiology / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
D003208:Concanavalin A