title: The production of colibacillosis in turkeys following sequential exposure to Newcastle disease virus or Bordetella avium, avirulent hemorrhagic enteritis virus, and Escherichia coli.
abstract: Female large white turkeys were intranasally inoculated with either Newcastle disease virus (ND) or Bordetella avium (BA) at 4 weeks of age. This was followed by oral inoculation with an avirulent (vaccine) strain of hemorrhagic enteritis virus (HE) at 5 weeks and intravenous inoculation with Escherichia coli (EC) at 6 weeks. Control birds received ND, BA, or HE followed by EC; EC alone; or nothing at all. Turkeys receiving one agent prior to EC challenge did not experience a significant increase in mortality or pericarditis. Those exposed to ND or BA followed by HE and EC experienced a significant elevation in mortality and pericarditis. A highly significant positive correlation between the number of infectious agents encountered during primary exposure and the incidence of colibacillosis after EC challenge was demonstrated.
authors.affiliation: Department of Large Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg 24061-0442, USA.
authors.forename: F W
authors.initials: FW
authors.lastname: Pierson
authors.forename: C T
authors.initials: CT
authors.lastname: Larsen
authors.forename: C H
authors.initials: CH
authors.lastname: Domermuth
mesh_terms: D000281:Administration, Intranasal; D000284:Administration, Oral; D000818:Animals; D001884:Bordetella / Q000502:physiology*; D001885:Bordetella Infections / Q000175:diagnosis / Q000453:epidemiology / Q000662:veterinary; D004754:Enterobacter / Q000502:physiology*; D004756:Enterobacteriaceae Infections / Q000175:diagnosis / Q000453:epidemiology / Q000662:veterinary*; D004926:Escherichia coli / Q000502:physiology*; D004927:Escherichia coli Infections / Q000175:diagnosis / Q000453:epidemiology / Q000662:veterinary; D005260:Female; D015994:Incidence; D009521:Newcastle Disease / Q000175:diagnosis / Q000453:epidemiology; D009522:Newcastle disease virus / Q000502:physiology*; D010493:Pericarditis / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary; D011201:Poultry Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D011897:Random Allocation; D014422:Turkeys