title: Prenatal diagnosis of supernumerary der(22)t(11;22) associated with the Dandy-Walker malformation in a fetus.
abstract: We present the first report of prenatally diagnosed Dandy-Walker malformation with the karyotype of partial trisomy 11 and 22 due to familial translocation t(11;22)(q23;q11) inherited in three generations. We demonstrate that the Dandy-Walker malformation can be an associated congenital malformation of supernumerary der(22)t(11;22) syndrome and emphasize the importance of chromosomal analysis and genetic counselling in the obstetric management of prenatally diagnosed Dandy-Walker malformation.
authors.affiliation: Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan, Republic of China.
authors.forename: C P
authors.initials: CP
authors.lastname: Chen
authors.forename: F F
authors.initials: FF
authors.lastname: Liu
authors.forename: S W
authors.initials: SW
authors.lastname: Jan
authors.forename: Y C
authors.initials: YC
authors.lastname: Yang
authors.forename: C C
authors.initials: CC
authors.lastname: Lan
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11; D002892:Chromosomes, Human, Pair 22; D003616:Dandy-Walker Syndrome / Q000235:genetics*; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014178:Translocation, Genetic; D014314:Trisomy; D016216:Ultrasonography, Prenatal