High doses of alcohol increase urinary testosterone-to-epitestosterone ratio in females.
The effect of alcohol (1.2 and 2.0 g/kg) on the urinary testosterone-to-epitestosterone (T/E) ratio was studied by two experiments each conducted with four healthy females and males. The intake of 2.0 g/kg of ethanol within 5 h in the evening significantly increased plasma testosterone concentration and ratio of T/E in urine collected next morning in females. The results suggest that alcohol increases the T/E ratio more in females than in males. The effect of high doses of alcohol on urinary T/E ratio must be kept in mind when doping tests are performed during training periods.
Karila
T
T
National Public Health Institute, Laboratory of Pharmacology and Toxicology, Helsinki, Finland.
Kosunen
V
V
Leinonen
A
A
Tähtelä
R
R
Seppälä
T
T
D000311:Adrenal Glands / Q000187:drug effects; D000328:Adult; D000428:Alcohol Drinking; D004300:Doping in Sports; D004845:Epitestosterone / Q000097:blood / Q000652:urine*; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D012739:Gonadal Steroid Hormones / Q000097:blood / Q000652:urine; D006801:Humans; D008099:Liver / Q000187:drug effects; D008297:Male; D012727:Sex Characteristics; D015813:Substance Abuse Detection; D013739:Testosterone / Q000097:blood / Q000652:urine*
D012739:Gonadal Steroid Hormones; D000431:Ethanol; D013739:Testosterone; D004845:Epitestosterone