Successful pregnancy after conditioning with cyclophosphamide and fractionated total body irradiation.
We report the case of a 24-year-old man who received high-dose cyclophosphamide (CY) 120 mg/kg over 2 days and twice daily fractionated total body irradiation (TBI) over 3 days(1,320 cGy) prior to allogeneic bone marrow transplantation. Seven and one-half years later he fathered a normal child who has developed normally so far.
Letendre
L
L
Department of Hematology, Mayo Foundation, Rochester, Minnesota 55905, USA.
Moore
S B
SB
D000328:Adult; D016465:Bone Marrow Purging / Q000009:adverse effects*; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D003520:Cyclophosphamide / Q000009:adverse effects*; D005220:Fathers; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007248:Infertility, Male / Q000209:etiology*; D008297:Male; D011247:Pregnancy; D014916:Whole-Body Irradiation / Q000009:adverse effects*
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide