[Effect of treating glomerulonephritis with omega 3 fatty acids for selected parameters of hemostasis, blood platelet function and lipid metabolism].
Disturbances in serum lipids, hemostasis and platelet functions are frequent features in some kidney diseases and may contribute to the progression of atherosclerosis with its complications. Recently, an attention has been paid on beneficial effects of fish oil on serum lipids and hemostasis, and proteinuria. The purpose of this work was to assess platelet functions, some hemostatic parameters and serum lipids in patients with chronic glomerulonephritis treated with Trienyl. The study was performed on 7 patients with glomerulonephritis, before, 3 and 6 months following fish oil treatment. A small and nonsignificant rise in cholesterol, HDL and LDL was found, whereas triglycerides level fell significantly following 3 and 6 months of therapy Fibrinogen concentration was lowered significantly 6 months following fish oil administration. Platelet aggregation in platelet-rich plasma remained unaltered during therapy, whereas platelet responses to ADP and arachidonic acid in the whole blood were inhibited after 6 months of the therapy. Unsaturated omega 3 fatty acids in Trienyl alter lipid metabolism, platelet/vessel wall interactions and proteinuria and therefore might be beneficial in therapy of glomerulonephritis, particularly in combination treatment.
Małyszko
J S
JS
Z Kliniki Nefrologii AM w Białymstoku, Kierownik Kliniki.
Małyszko
J
J
Pawlak
K
K
Myśliwiec
M
M
D000328:Adult; D001792:Blood Platelets / Q000187:drug effects*; D002908:Chronic Disease; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D005340:Fibrinogen / Q000032:analysis / Q000187:drug effects; D005395:Fish Oils / Q000627:therapeutic use*; D005921:Glomerulonephritis / Q000097:blood / Q000628:therapy*; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D008055:Lipids / Q000097:blood*; D010979:Platelet Function Tests; D014280:Triglycerides / Q000097:blood
D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D008055:Lipids; D014280:Triglycerides; C102870:trienyl; D005340:Fibrinogen