Interleukin-6-type cytokines in vivo: regulated bioavailability.
Investigators have traditionally thought of the class of inflammation- and injury-associated cytokines in large part as "free" entities in the peripheral circulation. In the case of interleukin-6 (IL-6), the cytokine can be found in blood in complexes of molecular mass 400-500, 150-200, and 25-35 kDa in association with binding proteins that can include soluble IL-6 receptor (sIL-6R), anti-IL-6, and anti-sIL-6R IgG, and others. Sustained high levels of different particular IL-6 complexes are observed in the human circulation in cancer patients subjected to particular active anticancer immunotherapy regimens. In the "chaperoned" state, circulating IL-6 complexes display differential immunoreactivity in different ELISAs and possess differential biological activity as assayed ex vivo. The discovery of "chaperoned" circulating IL-6 in humans points to a new level of modulation of cytokine function, that of regulated bioavailability of IL-6 in vivo.
Sehgal
P B
PB
Department of Cell Biology & Anatomy, New York Medical College, Valhalla, New York 10514, USA.
D000818:Animals; D015703:Antigens, CD; D016207:Cytokines / Q000502:physiology; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D009369:Neoplasms / Q000276:immunology; D018123:Receptors, Interleukin; D019947:Receptors, Interleukin-6
D015703:Antigens, CD; D016207:Cytokines; D015850:Interleukin-6; D018123:Receptors, Interleukin; D019947:Receptors, Interleukin-6