title: Enhancement of antipsychotic-like properties of the dopamine D2 receptor antagonist, raclopride, by the additional treatment with the 5-HT2 receptor blocking agent, ritanserin, in the rat.
abstract: The effects of 5-HT2 receptor blockade on the ability of a dopamine (DA) D2 receptor antagonist to produce suppression of conditioned avoidance response (CAR) and to produce catalepsy in rats were examined. It was found that ritanserin (2 mg kg-1 s.c.) enhanced the raclopride (0.1 mg kg-1 s.c.)-induced suppression of CAR without affecting raclopride-induced catalepsy at either maximal (4 mg kg-1 s.c.) or submaximal (0.2 mg kg-1 s.c.) doses. Considering the CAR performance as an index of mesocorticolimbic dopaminergic functions, it is concluded that 5-HT2 receptor blockade confers a limbic profile on the DA D2 receptor antagonist.
authors.affiliation: Department of Behavioral and Biochemical Pharmacology, Astra Arcus AB, Södertälje, Sweden.
authors.forename: M L
authors.initials: ML
authors.lastname: Wadenberg
authors.forename: P
authors.initials: P
authors.lastname: Salmi
authors.forename: P
authors.initials: P
authors.lastname: Jimenez
authors.forename: T
authors.initials: T
authors.lastname: Svensson
authors.forename: S
authors.initials: S
authors.lastname: Ahlenius
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D008297:Male; D020891:Raclopride; D051381:Rats; D017207:Rats, Sprague-Dawley; D016713:Ritanserin / Q000494:pharmacology*; D012457:Salicylamides / Q000494:pharmacology*
chemical_list: D014150:Antipsychotic Agents; D012457:Salicylamides; D016713:Ritanserin; D020891:Raclopride