The management of genital condylomas, intraepithelial neoplasia, and vulvodynia.
The natural history of HPV-related disease still is poorly understood. Screening of apparently healthy populations suggests that most HPV exposure results only in latent infection; that is, there is no active HPV DNA replication, but the HPV copy number is held at a steady state because viral replication parallels cell division. Unfortunately, knowledge of the cell-virus interaction and the host-immune response has not yet provided an effective medical therapy or a preventive vaccine. Rather, the management of HPV-induced disease remains rooted to the strategy of repeated local destruction. The physician should work methodically through a series of strategic decisions before committing to a management plan.
Reid
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Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA.
D002278:Carcinoma in Situ / Q000517:prevention & control*; D003218:Condylomata Acuminata / Q000473:pathology / Q000628:therapy*; D019092:Conization / Q000379:methods; D005260:Female; D005831:Genital Diseases, Female / Q000473:pathology / Q000628:therapy*; D005833:Genital Neoplasms, Female / Q000517:prevention & control*; D006801:Humans; D053685:Laser Therapy / Q000379:methods; D011247:Pregnancy; D014845:Vulvar Diseases / Q000628:therapy*