title: [Duodenal ulcer: clinical significance of adaptation defects in the system of neurohumoral regulation].
abstract: Radioimmunoassay was used to determine prostaglandin (PGE-2) and cyclic nucleotides (cAMP and cGMP) concentrations in the serum before, 1 and 2 hours after standard test breakfast (5066 kJ) in 65 patients with duodenal ulcer. Basal hyperproduction of prostaglandins and cyclic nucleotides were interpreted as an adaptation-compensatory mechanism. The unbalance of their aftermeal reactions persistent even in ulcer healing may belong to factors of the disease progression.
authors.affiliation: Mordva State University of NP Ogareva, Saransk.
authors.forename: E I
authors.initials: EI
authors.lastname: Eremina
mesh_terms: D000220:Adaptation, Biological; D000328:Adult; D001706:Biopsy; D000242:Cyclic AMP / Q000097:blood*; D006152:Cyclic GMP / Q000097:blood*; D015237:Dinoprost / Q000097:blood*; D015232:Dinoprostone / Q000097:blood*; D004381:Duodenal Ulcer / Q000097:blood* / Q000473:pathology; D016145:Endoscopy, Digestive System; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
chemical_list: D015237:Dinoprost; D000242:Cyclic AMP; D006152:Cyclic GMP; D015232:Dinoprostone