Simultaneous formation of peptides and nucleotides from N-phosphothreonine.
An intramolecular mutual activation between a phosphoryl group and carboxyl group results in the simultaneous formation of nucleotides and peptides by the reaction of nucleosides with N-(O,O-diisopropyl)phosphothreonine in anhydrous pyridine. These results suggest pathways for the simultaneous prebiotic synthesis of peptides and oligonucleotides.
Zhou
W
W
Bioorganic Phosphorus Chemistry Laboratory, Tsinghua University, Beijing, P.R. China.
Ju
Y
Y
Zhao
Y
Y
Wang
Q
Q
Luo
G
G
D002851:Chromatography, High Pressure Liquid; D019075:Electrophoresis, Capillary; D009705:Nucleosides / Q000737:chemistry; D009711:Nucleotides / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D010769:Phosphothreonine / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D009705:Nucleosides; D009711:Nucleotides; D010455:Peptides; D010769:Phosphothreonine