title: Localization of presenilin-1 mRNA in rat brain.
abstract: We examined the regional and cellular distribution of presenilin-1 gene expression in the rat brain by in situ hybridization. Microscopic analysis demonstrated that presenilin-1 mRNA is predominantly expressed in areas such as the occipital cortex, the pyramidal layer of the hippocampus, thalamic nuclei and the cerebellar granular layer. The expression of presenilin-1 is mostly neuronal: only a weak hybridization signal was found in the corpus callosum and in the astrocytoma cell lines U373MG and U138MG.
authors.affiliation: Rhône-Poulenc Rorer, Biology/Neurochemistry, CRVA, Vitry sur Seine, France.
authors.forename: D
authors.initials: D
authors.lastname: Quarteronet
authors.forename: L
authors.initials: L
authors.lastname: Pradier
authors.forename: C
authors.initials: C
authors.lastname: Czech
authors.forename: L
authors.initials: L
authors.lastname: Delalonde
authors.forename: M C
authors.initials: MC
authors.lastname: Burgevin
authors.forename: A
authors.initials: A
authors.lastname: Doble
authors.forename: F
authors.initials: F
authors.lastname: Petitet
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D017403:In Situ Hybridization; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D053764:Presenilin-1; D051381:Rats
chemical_list: D008565:Membrane Proteins; D053764:Presenilin-1