title: Pre-implantation embryonic loss induced by tributyltin chloride in rats.
abstract: The effect of tributyltin chloride (TBTCl) administered during early pregnancy on pregnancy maintenance was evaluated in rats. Inseminated females were orally administered TBTCl at a dose of 0, 8.1, 12.2 or 16.3 mg/kg on day 0 through day 7 of pregnancy. Females were sacrificed on day 20 of pregnancy and pregnancy outcome was determined. Pregnancy failure, which was evidenced by absence of implantation sites, was found in 0 of the 10, in 2 of the 11, in 10 of the 14 and in 10 of the 13 females at 0, 8.1, 12.2 and 16.3 mg/kg, respectively. The rate of pregnancy failure was significantly higher in the 12.2 and 16.3 mg/kg groups than that in the control group. In females with successful pregnancy, the numbers of corpora lutea, implantations and post-implantation loss per litter were comparable across all groups. No increase in the incidence of malformed fetuses was found in any TBTCl-treated groups. Thus it appears that TBTCl causes pregnancy failure after administration during very early pregnancy.
authors.affiliation: National Institute of Health Sciences, Osaka Branch, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Harazono
authors.forename: M
authors.initials: M
authors.lastname: Ema
authors.forename: Y
authors.initials: Y
authors.lastname: Ogawa
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D020964:Embryo Loss / Q000139:chemically induced; D047108:Embryonic Development / Q000187:drug effects*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005333:Fetus / Q000187:drug effects; D008297:Male; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012098:Reproduction / Q000187:drug effects; D014220:Trialkyltin Compounds / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D014220:Trialkyltin Compounds; C011559:tributyltin