title: Folate absorption in the caecum of chronic ethanol-fed rats: in vivo studies.
abstract: This study was designed to determine the intestinal in vivo absorption of folic acid and methyltetrahydrofolate (MTHF) by the caecum surface at different times after 20 weeks of 30% ethanol ingestion. The absorption results were compared to the data of control rats. Chow and fluid consumption and body weight were significantly lower in ethanol-fed rats. The absorption of folic acid and MTHF by the caecum surface (pmol/cm2) was generally decreased in ethanol-fed rats at all concentrations assayed with respect to control animals (except for absorption of 0.5 and 2.5 microM folic acid at 15-min intervals). The results obtained in the present work also suggest a different absorptive behaviour of folic acid and MTHF in the caecum under the influence of chronic alcohol ingestion.
authors.affiliation: Departamento de Fisiología y Biología Animal, Facultad de Farmacia, Universidad de Sevilla, España.
authors.forename: O
authors.initials: O
authors.lastname: Fernandez-Borrachero
authors.forename: J M
authors.initials: JM
authors.lastname: Rubio
authors.forename: M J
authors.initials: MJ
authors.lastname: Delgado
authors.forename: M L
authors.initials: ML
authors.lastname: Murillo
authors.forename: O
authors.initials: O
authors.lastname: Carreras Sánchez
mesh_terms: D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D002432:Cecum / Q000378:metabolism; D000431:Ethanol / Q000008:administration & dosage; D005492:Folic Acid / Q000378:metabolism*; D007408:Intestinal Absorption; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013763:Tetrahydrofolates / Q000378:metabolism
chemical_list: D013763:Tetrahydrofolates; D000431:Ethanol; D005492:Folic Acid; C005984:5-methyltetrahydrofolate