[The biomicroscopic evaluation of the blood microcirculatory bed in the mesentery of the small intestine during experimental perftoran infusion under normovolemia].
Dynamics of biomicroscopic state of hemomicrocirculatory bed (HMCB) of small intestinal mesentery was studied in go both sexes albino outbred rats in conditions of intravenous administration of 1.0 ml perfuoram (PF) with simultaneous control of the experiment by intravenous isotonic solution administration. Biomicroscopy was performed 30 minutes, 3, 6 and 24 hours later. 30 minutes after the PF administration bloodflow reduction in afferent vessels, elongation of construction period of resistant vessels and 18% decrease of vessels were demonstrated. Precapillary diameter decreased on 23% with respect to control with isotonic solution. Tortuosity of precapillaries and decrease of functioning capillaries number. 3 hours after the PF infusion blood flow turned more slow, signs of adhesion between leukocytes and postcapillary venules lumenal surface appeared and perivascular infiltrate had formed. Diameter of alducent vessels reduced in comparison with control and went lugher against the 30-minutes research stage. On the whole bloodflow in resistant vessels turns homogeneous. 6 hours after PF infusion homogeneous bloodflow could be seen. Number of arteriolar vasomotions grew up to control and made 14 in a minute. Venular diameter was close to control. Biomicroscopy of HMCB 24 hours after infusion did not reveal essential differences compared to with isotonic solution administered.
Golubev
A M
AM
Magomedov
M A
MA
Leont'eva
T A
TA
Guseĭnov
T S
TS
D000818:Animals; D001802:Blood Substitutes / Q000008:administration & dosage*; D001810:Blood Volume; D005260:Female; D005466:Fluorocarbons / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D007421:Intestine, Small / Q000098:blood supply* / Q000187:drug effects; D008297:Male; D008643:Mesentery / Q000098:blood supply* / Q000187:drug effects; D008833:Microcirculation / Q000033:anatomy & histology / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D001802:Blood Substitutes; D005466:Fluorocarbons; C063334:perftoran