Effect of sesamin on the composition of eicosapentaenoic acid in liver and on its lymphatic absorption in rats.
Changes in the hepatic concentration of n-3 fatty acids, e.g., eicosapentaenoic acid and linolenic acid, were significantly reduced by their simultaneous administration with sesamin, whereas there was no such effect of sesamin for n-6 and n-9 fatty acids. However, there was no significant difference in lymphatic absorption between eicosapentaenoic acid (n-3) and arachidonic acid (n-6), irrespective of the presence of absence of sesamin.
Umeda-Sawada
R
R
Institute of Environmental Science for Human Life, Ochanomizu University, Tokyo, Japan.
Ogawa
M
M
Okada
Y
Y
Igarashi
O
O
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D004149:Dioxoles / Q000494:pharmacology*; D015118:Eicosapentaenoic Acid / Q000737:chemistry / Q000378:metabolism*; D005227:Fatty Acids / Q000032:analysis; D017705:Lignans; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008208:Lymphatic System / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000924:Anticholesteremic Agents; D004149:Dioxoles; D005227:Fatty Acids; D017705:Lignans; D015118:Eicosapentaenoic Acid; C054125:sesamin