title: Obstructive atelectasis in patients with small cell lung cancer. Incidence and response to treatment.
abstract: OBJECTIVE
  Define the incidence of obstructive atelectasis in patients presenting with small cell lung cancer and their response to treatment.
  
  
  METHODS
  Retrospective review of clinical records and radiographic studies.
  
  
  METHODS
  Single federal government institution-the National Cancer Institute-Naval Medical Oncology Branch.
  
  
  METHODS
  One hundred seventy-two consecutive patients treated between 1983 and 1993.
  
  
  METHODS
  Patients presenting with obstructive atelectasis were identified. The incidence of dyspnea, cough, and sputum production before starting treatment and 1, 3, and 6 months later was determined. Fiberoptic bronchoscopy and chest radiographs performed before starting treatment were compared with those obtained later in the patients' clinical course.
  
  
  RESULTS
  Thirty-seven of 172 (22%) patients had obstructive atelectasis. Initial symptoms included cough in 25 (68%), dyspnea in 24 (65%), and productive cough in 10 (27%). The patients' symptoms of cough, dyspnea, and sputum production decreased to one third of the initial prevalence 1 month after the start of treatment. Fiberoptic bronchoscopy and chest radiographs performed 3 months after starting treatment demonstrated bronchial patency in 90%.
  
  
  CONCLUSIONS
  Obstructive atelectasis occurs in approximately one fifth of patients presenting with small cell lung cancer. Chemotherapy and chemotherapy plus chest radiotherapy lead to symptomatic, bronchoscopic, and radiographic resolution in similar proportions of patients with obstructive atelectasis.
authors.affiliation: Department of Internal Medicine, National Naval Medical Center, Bethesda, Md 20889-5105, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Vaaler
authors.forename: J M
authors.initials: JM
authors.lastname: Forrester
authors.forename: M
authors.initials: M
authors.lastname: Lesar
authors.forename: M
authors.initials: M
authors.lastname: Edison
authors.forename: D
authors.initials: D
authors.lastname: Venzon
authors.forename: B E
authors.initials: BE
authors.lastname: Johnson
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001999:Bronchoscopy; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000188:drug therapy / Q000401:mortality; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008175:Lung Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000401:mortality; D008297:Male; D001261:Pulmonary Atelectasis / Q000000981:diagnostic imaging / Q000209:etiology*; D011859:Radiography; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents