[Combination of beta-interferon and laser-CO2 therapy in female HPV genitalis].
230 women affected by HPV genital infection diagnosed by macroscopic examination, colposcopy and Pap test, were divided into two groups, of 95 and 135 people respectively, homogeneous for lesion localization and extension. The first group was treated with laser CO2 and the second group was treated with laser CO2 and intramuscular beta-interferon. We evaluated the side effects, the clinical results and the incidence of recurrences after 1, 6 and 12 months after the complete destruction of the lesions. At the first control, in both groups, we found no persistence of the lesions. At the second control after 6 months recurrences were present in 19 patients of the first group and in 7 patients of the second group. 51 recurrences were present after 12 months in the first group and 14 in the second group. The difference, evaluated with the chi 2 test, was found to be statistically significant (p < 0.01 after 6 months and p < 0.001 after 12 months).
Facchini
C
C
Istituto di Clinica Ostetricia e Ginecologica, Università degli Studi, Siena.
Eremita
G A
GA
Bernabei
A
A
D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003627:Data Interpretation, Statistical; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use*; D053685:Laser Therapy; D008875:Middle Aged; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D014412:Tumor Virus Infections / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*
D000998:Antiviral Agents; D016899:Interferon-beta