Serum erythropoietin and granulocyte-macrophage-colony stimulating factor levels with megadose methylprednisolone treatment.
Serum erythropoietin (EPO) and granulocyte-macrophage-colony stimulating factor (GM-CSF) levels were determined in 12 children with acute and seven with chronic idiopathic thrombocytopenic purpura (ITP) prior to and during megadose methylprednisolone (MDMP) treatment by using enzyme-linked immunosorbant assay (ELISA) kits. It was shown that elevation of EPO and GM-CSF levels was correlated with an increase in hemoglobin (Hb), packed cell volume (PCV), red blood cell (RBC), leukocyte (Leu), polymorphonuclear leukocyte (PMN) and monocyte (Mo) counts during MDMP treatment.
Sayli
T R
TR
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara.
Ozsoylu
S
S
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D004921:Erythropoietin / Q000097:blood*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000627:therapeutic use; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000188:drug therapy*
D000893:Anti-Inflammatory Agents; D004921:Erythropoietin; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D008775:Methylprednisolone