Chondroid syringoma: an immunohistochemical study using antibodies to Ca 15-3, KA-93, Ca 19-9, CD44 and BM-1.
The expression of Ca 15-3, KA-93, Ca 19-9, CD44 and BM-1 in normal skin and chondroid syringoma was investigated immunohistochemically using antibodies to these antigens. In the normal skin, the eccrine ducts and/or secretory elements were positive for all these antigens. On the other hand, the apocrine ducts and/or secretory elements were positive for the antibodies to Ca 15-3, KA-93 and CD44. In chondroid syringoma, the luminal cells of tubuloglandular structures were positive for the antibodies to Ca 15-3 and BM-1, and partly positive for those to KA-93 and Ca 19-9. The basal cells of the tubular structures and solid nests were positive only for the antibody to CD44. Stromal cells in the myxoid area were positive for the antibodies to KA-93 and CD44, and the chondroid matrix was positive for the antibody to BM-1. It is suggested that chondroid syringoma might originate from, or differentiate into the ducts and/or secretory elements of the eccrine sweat glands. In addition, the significance of the expression of BM-1 in the chondroid matrix is discussed.
Tsuji
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Department of Dermatology, Nagoya City University Medical School, Japan.
D008949:Adenoma, Pleomorphic / Q000276:immunology* / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D018395:CA-19-9 Antigen / Q000096:biosynthesis; D006801:Humans; D018960:Hyaluronan Receptors / Q000096:biosynthesis; D007124:Immunoenzyme Techniques; D018396:Mucin-1 / Q000096:biosynthesis; D014176:Protein Biosynthesis; D011506:Proteins; D012468:Salivary Gland Neoplasms / Q000276:immunology* / Q000378:metabolism; D012867:Skin / Q000276:immunology* / Q000378:metabolism
D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D018960:Hyaluronan Receptors; D018396:Mucin-1; D011506:Proteins; C071041:BM-1, platelet aggregation inhibitor