title: Short-chain fructo-oligosaccharides reduce the occurrence of colon tumors and develop gut-associated lymphoid tissue in Min mice.
abstract: C57BL/6J-Min/+ mice, which are heterozygous for a non-sense mutation in the Apc gene, provide a model for both familial adenomatous polyposis and sporadic colon cancers. In our study, gut tumors and small intestine lymphoid nodules were counted in Min mice fed fiber-enriched diets for 6 weeks. Neither starch-free wheat bran nor resistant starch modified the number of tumors. However, short-chain fructo-oligosaccharides dramatically reduced the incidence of colon tumors and concomitantly developed gut-associated lymphoid tissue. Our experiment shows that short-chain fructo-oligosaccharides counteract advanced stages of colon carcinogenesis, possibly via stimulation of antitumoral immunity by modulation of the colonic ecosystem.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale U 419, Human Nutrition Research Center of Nantes, Institut de Biologie, France.
authors.forename: F
authors.initials: F
authors.lastname: Pierre
authors.forename: P
authors.initials: P
authors.lastname: Perrin
authors.forename: M
authors.initials: M
authors.lastname: Champ
authors.forename: F
authors.initials: F
authors.lastname: Bornet
authors.forename: K
authors.initials: K
authors.lastname: Meflah
authors.forename: J
authors.initials: J
authors.lastname: Menanteau
mesh_terms: D000818:Animals; D001644:Bifidobacterium / Q000187:drug effects / Q000254:growth & development; D003106:Colon / Q000276:immunology / Q000382:microbiology; D003110:Colonic Neoplasms / Q000276:immunology / Q000517:prevention & control*; D004043:Dietary Fiber / Q000494:pharmacology*; D005260:Female; D005285:Fermentation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009844:Oligosaccharides / Q000737:chemistry / Q000494:pharmacology*; D010581:Peyer's Patches / Q000187:drug effects* / Q000254:growth & development; D011230:Precancerous Conditions / Q000276:immunology / Q000517:prevention & control*
chemical_list: D004043:Dietary Fiber; D009844:Oligosaccharides