Cancer-stromal interaction through growth factor/cytokine networks implicated in growth of stomach cancer.
Stomach cancer shows multiple gene changes, including both oncogenes and tumor suppressor genes. Among them, the one most frequently implicated in stomach cancer is the abnormal expression and amplification of the c-met gene. Moreover, stomach cancer cells express a broad spectrum of growth factors and cytokines that not only serve autocrine or paracrine growth of tumor cells, but also organize the complex networks between tumor cells and stromal cells. However, the scenario of cancer-stromal interaction differs depending on the two histological types-the well-differentiated or intestinal type and the poorly-differentiated or diffuse type-as the two types of stomach cancer may have different genetic pathways. The interaction between cell-adhesion molecules in the c-met overexpressed tumor cells and HGF from activated fibroblast may be involved in the progression and the morphogenesis of stomach cancer.
Tahara
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First Department of Pathology, Hiroshima University School of Medicine, Japan.
D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000502:physiology*; D002454:Cell Differentiation; D003238:Connective Tissue / Q000378:metabolism / Q000473:pathology*; D016207:Cytokines / Q000235:genetics / Q000502:physiology*; D005347:Fibroblasts / Q000378:metabolism; D005784:Gene Amplification; D015972:Gene Expression Regulation, Neoplastic; D006133:Growth Substances / Q000235:genetics / Q000502:physiology*; D017228:Hepatocyte Growth Factor / Q000502:physiology; D006801:Humans; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology*; D009363:Neoplasm Proteins / Q000235:genetics / Q000502:physiology*; D019859:Proto-Oncogene Proteins c-met; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000502:physiology*; D013274:Stomach Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D014407:Tumor Cells, Cultured
D015815:Cell Adhesion Molecules; D016207:Cytokines; D006133:Growth Substances; D009363:Neoplasm Proteins; D017228:Hepatocyte Growth Factor; D019859:Proto-Oncogene Proteins c-met; D020794:Receptor Protein-Tyrosine Kinases