c-Fos transrepression revisited.
The c-fos proto-oncogene was discovered by homology to transforming viral genes, leading to speculation that transforming viruses had captured a cellular gene involved in cell cycle control. Indeed overexpression of c-Fos protein led to deregulated growth control, and c-Fos was thought to be so critically involved in cell cycle control that transcriptional transrepression of its own promoter was interpreted as a negative feedback mechanism. However, recent findings render this conclusion improbable, Fos transrepression being most parsimoniously explained as transcriptional squelching imposed by artificially elevated levels of exogenous Fos protein.
Cahill
M A
MA
Transcriptional Regulation Group, Division of Immunology and Cell Biology, The John Curtin School of Medical Research, Australian National University, Canberra. Mike.Cahill@anu.edu.au
D016475:3T3 Cells; D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D005786:Gene Expression Regulation; D016762:Genes, fos; D051379:Mice; D016761:Oncogene Proteins v-fos / Q000235:genetics; D011401:Promoter Regions, Genetic; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics; D013234:Stem Cells; D014158:Transcription, Genetic
D016761:Oncogene Proteins v-fos; D016760:Proto-Oncogene Proteins c-fos