title: Spindle cell lipoma is strongly CD34 positive. An immunohistochemical study.
abstract: Spindle cell lipoma (SCL) is an uncommon soft tissue neoplasm that may provide diagnostic difficulty to the histopathologist. Four retrospectively identified SCLs were evaluated immunohistochemically with a broad panel of antibodies (CD34, factor XIIIa, S-100, actin and factor VIII). All four SCLs were strongly CD34 positive (95 to 100% of cells) and focally factor XIIIa positive (average 16% of cells). Tumor cells were S-100, actin and factor VIII negative. Dermatofibrosarcoma protuberans, neurofibroma, schwannoma and angiolipoma are CD34 positive tumors that have some similar histologic features to SCL and may be considered in the differential diagnosis. Differentiation is possible using a broad panel of immunostains and routine diagnostic criteria.
authors.affiliation: Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
authors.forename: S F
authors.initials: SF
authors.lastname: Templeton
authors.forename: A R
authors.initials: AR
authors.lastname: Solomon
mesh_terms: D000199:Actins / Q000032:analysis; D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis*; D003937:Diagnosis, Differential; D005169:Factor VIII / Q000032:analysis; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008067:Lipoma / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D009418:S100 Proteins / Q000032:analysis; D012983:Soft Tissue Neoplasms / Q000473:pathology*; D011503:Transglutaminases / Q000032:analysis
chemical_list: D000199:Actins; D018952:Antigens, CD34; D009418:S100 Proteins; D005169:Factor VIII; D011503:Transglutaminases