title: Effects of feeding Fusarium moniliforme culture material, containing known levels of fumonisin B1, in the young turkey poult.
abstract: The effects of feeding Fusarium moniliforme culture material, containing known concentrations of fumonisin B1 (FB1), were studied in turkey poults. Day-old poults were allotted randomly to dietary treatments containing 0, 0.41, 0.82, 1.23, 1.64. 2.87, 4.10, 5.33, 6.56, and 7.79% fumonisin culture material (FCM). These levels of FCM supplied 0, 25, 50, 75, 100, 175, 250, 325, 400, and 475 mg FB1/kg of feed. Each dietary treatment was fed to six pen replicates of six poults each for 21 d. Poults fed FCM that supplied 325 to 475 mg FB1/kg diet had lower (P < 0.05) feed intakes and BW gains. Increased (P < 0.05) liver and pancreas weights were observed in poults fed FCM that supplied > or = to 175 mg FB1/kg. Poults fed FCM that supplied 400 and 475 mg FB1/kg diet had increased (P < 0.05) red blood cell counts and increased (P < 0.05) serum concentrations of gamma glutamyl transferase and aspartate aminotransferase. Compared with controls, poults fed FCM that supplied 25, and 75 to 475 mg FB1/kg had increased (P < 0.05) liver sphinganine:sphingosine ratios. Hepatocellular hyperplasia was mild at 75 and 100 mg FB1/kg diet, moderate to severe at 250 mg/kg FB1, and severe at 325 to 475 mg FB1/kg. Multifocal to generalized loss of cross striations and thinning of cardiomyocytes was observed in poults fed FCM that supplied 475 mg FB1/kg diet. Results indicated that diets containing < or = to 1.23% FCM that supplied > or = to 75 mg FB1 /kg are toxic to young turkeys.
authors.affiliation: Fusarium/Poultry Research Laboratory, University of Missouri, Columbia 65211, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Ledoux
authors.forename: A J
authors.initials: AJ
authors.lastname: Bermudez
authors.forename: G E
authors.initials: GE
authors.lastname: Rottinghaus
mesh_terms: D000818:Animals; D002264:Carboxylic Acids / Q000008:administration & dosage / Q000633:toxicity*; D002274:Carcinogens, Environmental / Q000633:toxicity*; D004032:Diet; D004305:Dose-Response Relationship, Drug; D004734:Energy Metabolism / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D037341:Fumonisins; D005670:Fusarium; D006400:Hematocrit; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D010179:Pancreas / Q000033:anatomy & histology / Q000187:drug effects / Q000473:pathology; D011531:Proventriculus / Q000033:anatomy & histology / Q000187:drug effects / Q000473:pathology; D014422:Turkeys; D015430:Weight Gain / Q000187:drug effects
chemical_list: D002264:Carboxylic Acids; D002274:Carcinogens, Environmental; D037341:Fumonisins; C056933:fumonisin B1