Enhancement of nitric oxide production from activated macrophages by glycyrrhizin.
We studied the actions of glycyrrhizin on nitric oxide production from macrophages and a macrophage cell line RAW264-7. Although glycyrrhizin did not induce nitric oxide from resting macrophages, it enhanced the production of nitric oxide from IFN-gamma activated-macrophages or RAW cells. Glycyrrhizin also enhanced the production of nitric oxide from macrophages stimulated with the supernatant of con A-activated spleen cells. Further, glycyrrhizin enhanced tumor cell killing by macrophages activated with IFN-gamma. This tumor cell killing was mainly by nitric oxide.
Yi
H
H
Department of Immunology, Nagoya University School of Medicine, Japan.
Nakashima
I
I
Isobe
K
K
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D019695:Glycyrrhizic Acid; D008264:Macrophages / Q000187:drug effects*; D008516:Medicine, Chinese Traditional; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009569:Nitric Oxide / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D009569:Nitric Oxide; D019695:Glycyrrhizic Acid; D006034:Glycyrrhetinic Acid