title: hDIP--a potential transcriptional regulator related to murine TSC-22 and Drosophila shortsighted (shs)--is expressed in a large number of human tissues.
abstract: We have cloned a 420 bp cDNA from a human fetal brain cDNA library in lambda encoding the human homologue of a DSIP-immunoreactive leucine zipper protein (DIP) isolated from porcine brain. The derived human protein (hDIP) shares a significant sequence identity with parts of the murine TSC-22 and Drosophila shs, both proteins which are discussed as functioning as transcriptional regulators. A similar role of hDIP is partially confirmed by the results of an RT-PCR analysis, demonstrating the widespread distribution of the protein among different human tissues.
authors.affiliation: Lower Saxony Institute for peptide Research, Hannover, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Vogel
authors.forename: H J
authors.initials: HJ
authors.lastname: Mägert
authors.forename: A
authors.initials: A
authors.lastname: Cieslak
authors.forename: K
authors.initials: K
authors.lastname: Adermann
authors.forename: W G
authors.initials: WG
authors.lastname: Forssmann
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D001921:Brain / Q000196:embryology; D003001:Cloning, Molecular; D017124:Conserved Sequence; D018076:DNA, Complementary / Q000737:chemistry; D003701:Delta Sleep-Inducing Peptide / Q000737:chemistry*; D004330:Drosophila / Q000378:metabolism; D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans; D016350:Leucine Zippers / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D011506:Proteins / Q000737:chemistry*; D012097:Repressor Proteins; D017421:Sequence Analysis; D017386:Sequence Homology, Amino Acid; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D018076:DNA, Complementary; D011506:Proteins; D012097:Repressor Proteins; C099726:TSC22D1 protein, human; C490983:Tgfb1i4 protein, mouse; D003701:Delta Sleep-Inducing Peptide