Acute mechanical hyperalgesia in the rat can be produced by coactivation of spinal ionotropic AMPA and metabotropic glutamate receptors, activation of phospholipase A2 and generation of cyclooxygenase products.
Meller
S T
ST
Department of Pharmacology, University of Iowa, Iowa City 52242, USA.
Dykstra
C
C
Gebhart
G F
GF
D000208:Acute Disease; D000818:Animals; D004789:Enzyme Activation; D006930:Hyperalgesia / Q000378:metabolism*; D010741:Phospholipases A / Q000378:metabolism*; D054467:Phospholipases A2; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D051381:Rats; D018091:Receptors, AMPA / Q000378:metabolism*; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism*; D013314:Stress, Mechanical
D018091:Receptors, AMPA; D018094:Receptors, Metabotropic Glutamate; D011451:Prostaglandin-Endoperoxide Synthases; D010741:Phospholipases A; D054467:Phospholipases A2