Solcoseryl stimulates behavioural activity of rats.
The influence of Solcoseryl (S), a protein-free extract of calves' blood given intraperitoneally (i.p.) on the behavioural measures of activity of the central nervous system of male Wistar rats was examined. The drug (1.0 ml/kg i.p.) given 60 min before testing the animals in electromagnetic motimeter significantly enhanced overall and vertical motility of rats. S at the doses of 0.5, 1.0 and 2.0 ml/kg did not significantly influence the activity of rats in "open field". 1.0 ml/kg of S given 15, 45 and 60 min before thiopental (30 mg/kg i.p.) did not change the onset and time of sleep following the latter drug, except for the significant shortening of the time of sleep of animals injected with S 15 min before thiopental. S at the dose of 1.0 ml/kg did not change stereotypies produced by apomorphine (2.0 mg/kg i.p.) and amphetamine (6.5 mg/kg i.p.) but decreased intensity of haloperidol (1.0 mg/kg i.p.) catalepsy.
Braszko
J J
JJ
Department of Pharmacology, Medical Academy, Bialystok, Poland.
Winnicka
M M
MM
Wiśniewski
K
K
D000183:Actihaemyl / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002375:Catalepsy / Q000139:chemically induced; D018492:Dopamine Antagonists; D005106:Exploratory Behavior / Q000187:drug effects; D006220:Haloperidol; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects; D013268:Stimulation, Chemical; D013874:Thiopental / Q000494:pharmacology
D018492:Dopamine Antagonists; D006993:Hypnotics and Sedatives; D000183:Actihaemyl; D006220:Haloperidol; D013874:Thiopental