title: [Plasmacytomas of the head and neck].
abstract: Neoplastic proliferation of plasma cells results in a population of immunologically homogeneous cells that can produce diffuse (multiple myeloma) or localized (extramedullary plasmacytomas and solitary plasmacytoma of bone) disease. In otorhinolaryngologic literature these neoplasms are rarely described and their nosological arrangement is often confused. The presence of a plasma cell neoplasm can be a surprise and sometimes a diagnostic challenge to the head and neck surgeon. Proper management of such lesions needs to be individualized according to their expected biologic behaviour. The recent observation of a case of maxillary sinus plasmacytoma suggested the Authors to carefully review the literature, drawing their attention mainly on the current histogenetic hypotheses and their consequences in therapeutic strategy. The correct diagnostic procedure is also explained, highlighting the difficulties due to both the protean nature of the disease and the still existing nosological confusion. The possibility of a plasma cell tumour should be never forgotten in presence of an head and neck neoplasm. Because these neoplasms may signal the presence of multiple mieloma, full evaluation is required to exclude disseminated disease. In light of recent histogenetic acquisitions it is suggested that extramedullary plasmacytomas can be classified among the so-called "mucosa-associated" lymphomas. Possible following differences in therapeutic approach and long-term follow-up are also indicated, stressing the role of surgery in managing these disorders. Surgical excision of extramedullary plasmacytomas followed by complementary radiotherapy on the site of tumour is proposed as the best treatment for these kind of neoplasms. This is in opposition with "classical" statement considering radiotherapy the only treatment for this kind of disorders.
authors.affiliation: Divisione di Otorinolaringoiatria e Chirurgia Cervico-Facciale, Istituto per lo Studio e la Cura dei Tumori Regina Elena, Roma.
authors.forename: E
authors.initials: E
authors.lastname: Marzetti
authors.forename: A
authors.initials: A
authors.lastname: Marzetti
authors.forename: O
authors.initials: O
authors.lastname: Palma
authors.forename: R W
authors.initials: RW
authors.lastname: Pezzuto
mesh_terms: D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010255:Paranasal Sinus Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D010256:Paranasal Sinuses / Q000473:pathology* / Q000528:radiation effects / Q000601:surgery; D010954:Plasmacytoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D012307:Risk Factors; D014057:Tomography, X-Ray Computed