Modulating platelet function with selective thrombin inhibitors.
In addition to its pivotal role in blood coagulation, thrombin is one of the most important agonists for platelet recruitment and aggregation. Thrombin inhibitors impede thrombin-induced platelet aggregation but have no effect on aggregation induced by other agonists. A review is presented of selective thrombin inhibitors now in clinical investigation, some of which are also orally active.
Verstraete
M
M
Center for Molecular and Vascular Biology, University of Leuven, Belgium.
D000284:Administration, Oral; D000328:Adult; D000818:Animals; D000991:Antithrombins / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001120:Arginine / Q000031:analogs & derivatives; D001792:Blood Platelets / Q000187:drug effects*; D001896:Boron Compounds / Q000494:pharmacology; D002986:Clinical Trials as Topic; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005998:Glycine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D024764:Hirudin Therapy; D006629:Hirudins / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D006801:Humans; D009281:Naphthalenes / Q000494:pharmacology / Q000627:therapeutic use; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology; D010875:Pipecolic Acids / Q000494:pharmacology / Q000627:therapeutic use; D010880:Piperidines / Q000494:pharmacology / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D013449:Sulfonamides; D013917:Thrombin / Q000037:antagonists & inhibitors*
D000991:Antithrombins; D001896:Boron Compounds; D006629:Hirudins; D009281:Naphthalenes; D009842:Oligopeptides; D010446:Peptide Fragments; D010875:Pipecolic Acids; D010880:Piperidines; D011994:Recombinant Proteins; D013449:Sulfonamides; C066061:acetylphenylalanyl-prolyl-boroarginine; C099871:inogatran; D001120:Arginine; D013917:Thrombin; C031942:argatroban; D005998:Glycine; C074619:bivalirudin; C087198:napsagatran; C064289:efegatran