title: Empty sella, growth hormone deficiency and pseudotumour cerebri: effect of initiation, withdrawal and resumption of growth hormone therapy.
abstract: An 11-year-old boy with normal visus and eye fundus, but with empty sella, growth hormone (GH) deficiency and central diabetes insipidus was found to have intracranial hypertension with papilloedema after 6 months of catch-up growth under recombinant human GH (rhGH) replacement therapy. Withdrawal of rhGH therapy was associated with normalisation of intracranial pressure within 1 week. Three months later, resumption of rhGH therapy at a lower dose was again followed by pronounced growth acceleration, but now without papilloedema.
  
  
  CONCLUSIONS
  Children with empty sella and GH deficiency may be prone to rhGH-induced pseudotumour cerebri which appears to be rapidly reversible and dose-dependent.
authors.affiliation: Department of Paediatrics, U. Z. Gasthuisberg, Leuven, Belgium.
authors.forename: I
authors.initials: I
authors.lastname: Francois
authors.forename: I
authors.initials: I
authors.lastname: Casteels
authors.forename: J
authors.initials: J
authors.lastname: Silberstein
authors.forename: P
authors.initials: P
authors.lastname: Casaer
authors.forename: F
authors.initials: F
authors.lastname: de Zegher
mesh_terms: D002648:Child; D003919:Diabetes Insipidus / Q000150:complications; D004652:Empty Sella Syndrome / Q000150:complications* / Q000473:pathology; D006130:Growth Disorders / Q000150:complications / Q000628:therapy; D013006:Growth Hormone / Q000008:administration & dosage / Q000009:adverse effects* / Q000172:deficiency* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011559:Pseudotumor Cerebri / Q000209:etiology*
chemical_list: D013006:Growth Hormone