title: A modification of the N-terminal amino acid in the eremomycin aglycone.
abstract: An Edman degradation of the antibiotic eremomycin aglycone produced the corresponding hexapeptide, which was aminoacylated with D-lysine, D-histidine or D-tryptophan derivatives to give new heptapeptide analogs of the eremomycin aglycone. The aminoacylation of the eremomycin aglycone produced an octapeptide analog. The substitution of D-lysine for the N-terminal N-methyl-D-leucine does not seriously affect the in vitro antibacterial properties of the eremomycin aglycone whereas the heptapeptides with the N-terminal D-tryptophan or D-histidine moieties and the octapeptide with the N-terminal D-lysine are practically devoid of the antibacterial properties.
authors.affiliation: Institute of New Antibiotics, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Miroshnikova
authors.forename: T F
authors.initials: TF
authors.lastname: Berdnikova
authors.forename: E N
authors.initials: EN
authors.lastname: Olsufyeva
authors.forename: A Y
authors.initials: AY
authors.lastname: Pavlov
authors.forename: M I
authors.initials: MI
authors.lastname: Reznikova
authors.forename: M N
authors.initials: MN
authors.lastname: Preobrazhenskaya
authors.forename: R
authors.initials: R
authors.lastname: Ciabatti
authors.forename: A
authors.initials: A
authors.lastname: Malabarba
authors.forename: L
authors.initials: L
authors.lastname: Colombo
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides; D006020:Glycopeptides; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D006020:Glycopeptides; D010455:Peptides; C053759:eremomycin; C057759:eremomycin aglycone