A flowcytometric study of CD4+ & CD19+ cell lymphopenia in patients with alopecia areata.
Twenty five patients with alopecia areata and 20 healthy controls were studied by flowcytometry employing direct two colour immunofluorescence in erythrocyte lysed whole blood. A significant reduction was observed in helper/inducer (CD4+) lymphocytes (29.4 +/- 7.4 vs 39.45 +/- 8.0, P < 0.01) and B (CD 19+) lymphocytes (11.04 +/- 6.57 vs 15.0 +/- 5.05, P < 0.01) in comparison with healthy controls. Decrease in T-lymphocytes (CD3+) and suppressor/cytotoxic (CD8+) was not significant and activated (HLADR+) lymphocytes and natural killer cells (CD16+ and CD56+) were within normal limits. Our findings suggest a significant T helper (CD4+) and B (CD19+) cell lymphopenia in alopecia areata.
Sharma
V K
VK
Department of Dermatology, Postgraduate Institute of Medical Education & Research, Chandigarh.
Agnihotri
N
N
Ganguly
N K
NK
Vohra
H
H
D000293:Adolescent; D000328:Adult; D000506:Alopecia Areata / Q000276:immunology*; D018941:Antigens, CD19 / Q000097:blood*; D015704:CD4 Antigens / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008231:Lymphopenia / Q000276:immunology*; D008297:Male
D018941:Antigens, CD19; D015704:CD4 Antigens