title: [Questions and answers on adjuvant systemic therapy in breast carcinoma].
abstract: We review controversial issues taken from the vast literature on adjuvant treatment of early breast cancer. We conclude that the role of tamoxifen in premenopausal women is still controversial and that ovariectomy in this patient population cannot be routinely recommended outside clinical trials. The current literature certainly supports the use of anthracyclines in adjuvant chemotherapy regimens, but we feel that high dose chemotherapy with peripheral blood stem cell support should still be restricted to randomized clinical trials. Finally, we would like to emphasize that the current standard of adjuvant treatment of early breast cancer are prospectively randomized clinical trials which provide a stronghold of good patient care and will allow to tackle and answer important controversial issues regarding this frequent cancer.
authors.affiliation: Institut für Medizinische Onkologie, Universität Bern, Inselspital.
authors.forename: M F
authors.initials: MF
authors.lastname: Fey
authors.forename: M
authors.initials: M
authors.lastname: Castiglione-Gertsch
mesh_terms: D000328:Adult; D000368:Aged; D018943:Anthracyclines / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008875:Middle Aged; D010052:Ovariectomy; D013629:Tamoxifen / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D018943:Anthracyclines; D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen