title: Immunohaematological findings in healthy and HIV-1 infected adults in Dar es Salaam, Tanzania.
abstract: In order to assess the prognostic value of lymphocyte subsets and immune activation markers in HIV-1 infected Tanzanian patients, peripheral white blood cell(WBC) count, total lymphocytes, CD4+ and CD8+ T-lymphocytes and Beta-2 microglobulin (B-2M) concentrations were determined among healthy HIV-1 seronegative Tanzanian blood donors and in infected Tanzania individuals in different clinical stages of HIV-1 infection. CD4+ T-lymphocytes, CD8+ T-lymphocyte percentages, CD4:CD8 lymphocyte ratios and the concentrations of B-2M were strongly correlated with the clinical stages of HIV-1 infection. These results suggest that B-2M could be a useful prognostic marker in HIV-1 infection in settings where T-lymphocyte subset determinations cannot be done.
authors.affiliation: Department of Microbiology and Immunology, Muhimbili University College, Dar es Salaam, Tanzania.
authors.forename: W K
authors.initials: WK
authors.lastname: Urassa
authors.forename: E F
authors.initials: EF
authors.lastname: Lyamuya
authors.forename: E
authors.initials: E
authors.lastname: Mbena
authors.forename: C
authors.initials: C
authors.lastname: Kagoma
authors.forename: U
authors.initials: U
authors.lastname: Bredberg Raden
authors.forename: K P
authors.initials: KP
authors.lastname: Pallangyo
authors.forename: P
authors.initials: P
authors.lastname: Magessa
authors.forename: F S
authors.initials: FS
authors.lastname: Mhalu
authors.forename: G
authors.initials: G
authors.lastname: Biberfeld
mesh_terms: D000328:Adult; D016516:CD4-CD8 Ratio; D016022:Case-Control Studies; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000145:classification / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D016130:Immunophenotyping; D016131:Lymphocyte Subsets; D008297:Male; D011379:Prognosis; D015203:Reproducibility of Results; D013636:Tanzania; D014504:Urban Health; D001613:beta 2-Microglobulin / Q000276:immunology*
chemical_list: D001613:beta 2-Microglobulin