title: Caparratriene, an active sesquiterpene hydrocarbon from Ocotea caparrapi.
abstract: Caparratriene (1), a new sesquiterpene hydrocarbon with significant growth inhibitory activity (IC50 = 3.0 +/- 0.5 x 10(-6) M) against CEM leukemia cells, was isolated from the oil of Ocotea caparrapi (Nates) Dugand. The structure of 1, determined by spectroscopic techniques, corresponded to (E,E)-3,7,11-trimethyl-2,4,10-dodecatriene (C15H26).
authors.affiliation: Walker Cancer Research Institute, Detroit, Michigan 48201, USA.
authors.forename: E
authors.initials: E
authors.lastname: Palomino
authors.forename: C
authors.initials: C
authors.lastname: Maldonado
authors.forename: M B
authors.initials: MB
authors.lastname: Kempff
authors.forename: M B
authors.initials: MB
authors.lastname: Ksebati
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D003105:Colombia; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007942:Leukemia, Experimental / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; C102616:caparratriene