Use of the lethal body burden in the evaluation of mixture toxicity.
In many mixtures of xenobiotics in the field situation, narcosis is the predominant mechanism of toxic action. Earlier studies have found that narcotic chemicals are additive based on exposure concentration. In this study it is revealed that the narcotic chemicals 1,2- and 1,4-dichlorobenzene are additive on a lethal body burden level. This applicability of the lethal body burden in risk assessment of mixtures of unknown chemicals is discussed, and it is compared with other methods of managing mixtures of unknown chemical composition.
van Wezel
A P
AP
Marine Chemistry, Public Works and Water Management, The Hague, NL-2500 EX, The Netherlands.
de Vries
D A
DA
Sijm DTHM
Opperhuizen
A
A
D000704:Analysis of Variance; D000818:Animals; D001822:Body Burden; D002273:Carcinogens / Q000378:metabolism / Q000633:toxicity*; D002722:Chlorobenzenes / Q000378:metabolism / Q000633:toxicity*; D002849:Chromatography, Gas; D003530:Cyprinidae; D005618:Fresh Water / Q000032:analysis; D007306:Insecticides / Q000378:metabolism / Q000633:toxicity*; D018570:Risk Assessment; D014874:Water Pollutants, Chemical / Q000378:metabolism / Q000633:toxicity
D002273:Carcinogens; D002722:Chlorobenzenes; D007306:Insecticides; D014874:Water Pollutants, Chemical; C004726:2-dichlorobenzene; C018511:4-dichlorobenzene