title: [Clinical pharmacology of 2-chlorodeoxyadenosine (Cladribine)].
abstract: 2-chlorodeoxyadenosine (2-CdA) is a simple nucleoside derived from deoxyadenosine by substituting chloride for hydrogen in 2' position of the purine ring, which renders it resistant to degradation by adenosine deaminase. Many studies have revealed high efficiency of 2-CdA in the treatment of lymphoid malignancies. Hairy cell leukemia is notably responsive to 2-CdA, with 85% of patients entering complete remissions after treatment of this drug.
authors.affiliation: Zakładu Farmakologii Akademii, Medycznej w Lodzi.
authors.forename: J
authors.initials: J
authors.lastname: Góra-Tybor
authors.forename: T
authors.initials: T
authors.lastname: Robak
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017338:Cladribine / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D007943:Leukemia, Hairy Cell / Q000188:drug therapy; D008232:Lymphoproliferative Disorders / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D017338:Cladribine