[Lipid derivatives of sarcolysin, methotrexate and rubomycin].
To change the pharmacokinetic properties of the known antitumor agents sarcolysine, rubomycin, and methotrexate, their lipid derivatives were synthesized with the residues of rac-1,2-dioleoylglycerol and heptadecyl alcohol. An ether lipid analog, 3-sarcolysyl 2-methyl-1-octadecyl-sn-glycerol, with the lipid moiety being itself an antineoplastic agent was also obtained.
Vodovozova
E L
EL
Nikol'skiĭ
P Iu
PIu
Mikhalev
I I
II
Molotkovskiĭ
Iu G
IuG
D003630:Daunorubicin / Q000031:analogs & derivatives*; D008055:Lipids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008558:Melphalan / Q000031:analogs & derivatives*; D008727:Methotrexate / Q000031:analogs & derivatives*; D013056:Spectrophotometry, Ultraviolet
D008055:Lipids; D008558:Melphalan; D008727:Methotrexate; D003630:Daunorubicin