[The ultrastructure of the neuronal subpopulations of the paraventricular hypothalamic nuclei in stress and the stress-limiting action of a pulsed electrical current].
Neurons of medial microcellular and posterior macrocellular subnuclei of hypothalamus, producing stress-releasing hormones (CRF and V), acting together in initiation and regulation of the organism stress reactions were studied. Ultrastructural analysis and automatized data could reveal decrease of secretory vesicles number and enlightenment of neurosecretory granules content in immobilization, which indicates active hormone elimination from neuron bodies. Characters of the disturbing stressor effect on different organelles, mainly on endoplasmic reticulum were found. Transcerebral electric current revealed protective stress-limiting action, determined by activation of nuclear and protein-producing cell mechanisms, which reflects on stress-releasing hormones synthesis and modulation. This expresses in the increase of secretory granules number, their significant enlargement, on hormone deponetion in neuron bodies with neuronal tolerance to disturbing stress effect growing higher.
Geniatullina
M S
MS
Korolev
Iu N
IuN
D000818:Animals; D003584:Cytological Techniques; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004580:Electronarcosis; D008297:Male; D008854:Microscopy, Electron; D009474:Neurons / Q000648:ultrastructure*; D010286:Paraventricular Hypothalamic Nucleus / Q000648:ultrastructure*; D051381:Rats; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000473:pathology* / Q000628:therapy*