title: Relative effectiveness coefficient: a quality characteristic of toothpastes containing active components.
abstract: It has been proposed that the parameter of relative effectiveness coefficient (REC) be used for the qualitative assessment of toothpastes containing active ingredients. REC is the ratio between the concentration of the active component in water eluates obtained after three minutes and adequately prolonged (up to the reaching of equilibrium state) dispersion of the toothpaste in distilled water at a 1:4 ratio (condition simulating the use of toothpaste in the oral cavity). The change in REC after storage following its production, as well as testing the toothpaste stability at high and low temperatures, provides an evidence for deviations in its quality. REC was applied for the assessment of toothpastes containing 0.5% zinc citrate as an active ingredient.
authors.affiliation: Department of Analytical Chemistry, Sofia Chemical, Technological and Metallurgical University, Bulgaria.
authors.forename: R
authors.initials: R
authors.lastname: Borissova
authors.forename: E
authors.initials: E
authors.lastname: Kirova
mesh_terms: D000537:Aluminum Oxide; D002119:Calcium Carbonate; D002130:Calcium Phosphates; D019343:Citric Acid; D011786:Quality Control; D012822:Silicon Dioxide; D014100:Toothpastes / Q000592:standards*; D015032:Zinc
chemical_list: D002130:Calcium Phosphates; D014100:Toothpastes; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; D019343:Citric Acid; C485838:calcium phosphate, monobasic, anhydrous; D012822:Silicon Dioxide; C020243:calcium phosphate; D002119:Calcium Carbonate; D015032:Zinc; C485829:calcium phosphate, dibasic, anhydrous; D000537:Aluminum Oxide