The complexities of viral genome analysis: the primate lentiviruses.
Analysis of sequence information from RNA-based replication systems continues to challenge the computational molecular biology community. Recent sequence data from the study of primate lentiviruses indicate that extreme sequence heterogeneity, recombination, and cross-species transmissions are all observed in HIV evolution. These types of events will continue to make the development of effective anti-retroviral therapies difficult.
McClure
M A
MA
Department of Biological Sciences, University of Nevada, Las Vegas 89154-4004, USA. mars@parvati.lv-whi.nevada.edu
D000818:Animals; D016679:Genome, Viral; D006801:Humans; D016086:Lentivirus / Q000235:genetics*; D011323:Primates / Q000821:virology