Identifying structure-function relationships in four-helix bundle cytokines: towards de novo mimetics design.
Many cytokines (growth-factor proteins) are constructed from a common four-helix bundle structural framework. Rapid advances have been made in relating the structure and function of a growing number of four-helix bundle cytokines. This understanding opens the way to design de novo mimetics through such strategies as cytokine hybrids, structure-excerpted scaffolds and contact residue topology mimics. These may provide leads for agonists and antagonists of cell growth and differentiation.
Chaiken
I M
IM
Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia 19104-6100, USA. chaiken@mail.med.upenn.edv
Williams
W V
WV
D000818:Animals; D001665:Binding Sites; D001709:Biotechnology / Q000639:trends; D016207:Cytokines / Q000737:chemistry* / Q000502:physiology*; D015195:Drug Design; D006801:Humans; D015394:Molecular Structure; D011487:Protein Conformation; D018121:Receptors, Cytokine / Q000737:chemistry / Q000502:physiology
D016207:Cytokines; D018121:Receptors, Cytokine