title: Failure of dobutamine to improve liver oxygenation during resuscitation with a crystalloid solution after experimental haemorrhagic shock.
abstract: OBJECTIVE
  To evaluate the effects of dobutamine on peripheral and hepatic tissue oxygen tensions during the treatment of haemorrhagic shock.
  
  
  METHODS
  Randomised, controlled trial.
  
  
  METHODS
  University hospital, Finland.
  
  
  METHODS
  12 Piglets, weight 20 kg.
  
  
  METHODS
  Haemorrhagic shock (40% of blood volume removed) and resuscitation with crystalloid solution. Dobutamine infused (6.5 micrograms/kg/min) during resuscitation in 6 animals and 6 served as controls.
  
  
  METHODS
  Haemodynamic and systemic oxygen transport variables. Hepatic, subcutaneous, transcutaneous, and conjunctival oxygen tensions measured continuously with polarographic electrodes.
  
  
  RESULTS
  All values decreased significantly during bleeding. Resuscitation restored the mean arterial pressure in both groups, and cardiac output exceeded the baseline by 24% in the dobutamine group (p < 0.05 compared with control). There was no difference in oxygen delivery and consequently tissue oxygen tensions remained at the control level in the dobutamine group.
  
  
  CONCLUSIONS
  Dobutamine infusion did not improve tissue oxygenation when used in addition to crystalloids to treat hypovolaemic shock.
authors.affiliation: Fourth Department of Surgery, Helsinki University Hospital, Finland.
authors.forename: A J
authors.initials: AJ
authors.lastname: Nordin
authors.forename: H
authors.initials: H
authors.lastname: Mäkisalo
authors.forename: K A
authors.initials: KA
authors.lastname: Höckerstedt
mesh_terms: D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D002316:Cardiotonic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004280:Dobutamine / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007552:Isotonic Solutions / Q000627:therapeutic use; D008099:Liver / Q000378:metabolism; D008102:Liver Circulation / Q000187:drug effects*; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption / Q000187:drug effects; D011897:Random Allocation; D012151:Resuscitation / Q000379:methods; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000378:metabolism / Q000628:therapy; D013552:Swine
chemical_list: D002316:Cardiotonic Agents; D007552:Isotonic Solutions; C028570:Ringer's acetate; D004280:Dobutamine; D010100:Oxygen