Radioprotective properties of flurbiprofen.
Repeated administration of flurbiprofen, an inhibitor of prostaglandin synthesis (IPS), was found to enhance haemopoiesis in mice exposed to a sublethal dose of fractionated gamma-irradiation (5 x 3 Gy, intervals between fractions 24 h). In lethally irradiated animals (5 x 3 Gy and an additional "top-up" dose of 3.5 Gy), a significantly better survival was found in mice given flurbiprofen than in control animals receiving saline. The latter result is a new positive phenomenon not observed in earlier experiments with other IPS. The findings suggest a possibility to extend the radiation dose range, in which the administration of IPS leads to radioprotective effects, also to higher, lethal radiation doses, by administering flurbiprofen instead of previously studied IPS indomethacin or diclofenac.
Hofer
M
M
Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic.
Pospísil
M
M
Pipalová
I
I
D000818:Animals; D005260:Female; D005480:Flurbiprofen / Q000008:administration & dosage*; D005720:Gamma Rays; D006098:Granulocytes / Q000187:drug effects / Q000528:radiation effects; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011448:Prostaglandin Antagonists / Q000008:administration & dosage*; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects
D011448:Prostaglandin Antagonists; D005480:Flurbiprofen