Pharmacology of cancer chemotherapy in the older person.
With more widespread use of effective chemotherapy, more elderly patients are candidates for treatment with cytotoxic drugs. This article reviews and discusses the relevant age-related factors that may alter drug disposition and its relationship to pharmacokinetics effects and to pharmacodynamic effects in the elderly.
Baker
S D
SD
Department of Pharmacology and Medicine, University of Texas Health Science Center, San Antonio, Texas, USA.
Grochow
L B
LB
D000368:Aged / Q000502:physiology*; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007408:Intestinal Absorption; D008657:Metabolic Clearance Rate; D014018:Tissue Distribution
D000970:Antineoplastic Agents