title: Morphea after silicone gel breast implantation for cosmetic reasons in an HLA-B8, DR3-positive woman.
abstract: We describe an HLA-B8, DR3-positive patient with localized morphea after silicone gel breast implantation for cosmetic reasons. We believe that this case suggests that a genetic background, i.e. HLA-B8, DR3 haplotype, is involved in the autoimmune response to silicone.
authors.affiliation: Cattedra di Medicina Interna II, Istituto di Medicina Interna e Geriatria Università di Palermo, Italia.
authors.forename: G
authors.initials: G
authors.lastname: Di Lorenzo
authors.forename: P
authors.initials: P
authors.lastname: Mansueto
authors.forename: M
authors.initials: M
authors.lastname: Melluso
authors.forename: G B
authors.initials: GB
authors.lastname: Sangiorgi
authors.forename: D
authors.initials: D
authors.lastname: Cigna
authors.forename: G
authors.initials: G
authors.lastname: Candore
authors.forename: C
authors.initials: C
authors.lastname: Caruso
mesh_terms: D000328:Adult; D018427:Breast Implants / Q000009:adverse effects*; D016516:CD4-CD8 Ratio; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D015795:HLA-B8 Antigen / Q000235:genetics / Q000276:immunology*; D015803:HLA-DR3 Antigen / Q000235:genetics / Q000276:immunology*; D006801:Humans; D016462:Mammaplasty; D011241:Prednisone / Q000627:therapeutic use; D012594:Scleroderma, Localized / Q000139:chemically induced* / Q000188:drug therapy / Q000276:immunology; D012828:Silicones / Q000009:adverse effects*; D013518:Surgery, Plastic
chemical_list: D005938:Glucocorticoids; D015795:HLA-B8 Antigen; D015803:HLA-DR3 Antigen; D012828:Silicones; D011241:Prednisone