title: Antimutagenicity of Tochu tea (an aqueous extract of Eucommia ulmoides leaves): 2. Suppressing effect of Tochu tea on the urine mutagenicity after ingestion of raw fish and cooked beef.
abstract: The effect of Tochu tea, which is an aqueous extract of Eucommia ulmoides leaves and a popular-beverage in Japan, on the urine mutagenicity before and after ingestion of raw fish and cooked beef was studied using Salmonella typhimurium YG1024. Urines were collected from seven healthy, non-smoking Japanese women before and after ingestion of raw fish and cooked beef. In experiment 1,3 were in a control group and 4 were in a Tochu tea-drinking group (2000 ml per day). The mutagenicity of urine from the Tochu tea-drinking group was much lower. In experiment 2 the 7 women switched groups; the tea-drinking group became the control group, and the control group became the Tochu tea-drinking group. Again, the mutagenicity of urine collected from the Tochu tea-drinking group was much lower. These results suggest that the decrease in the mutagenicity of the urine from the Tochu tea-drinking group was due to the intake of Tochu tea, but not to individual differences. Thus, the ingestion of Tochu tea may reduce human exposure to dietary mutagens.
authors.affiliation: Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Aomori, Japan.
authors.forename: Y F
authors.initials: YF
authors.lastname: Sasaki
authors.forename: A
authors.initials: A
authors.lastname: Chiba
authors.forename: M
authors.initials: M
authors.lastname: Murakami
authors.forename: K
authors.initials: K
authors.lastname: Sekihashi
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Takahoko
authors.forename: S
authors.initials: S
authors.lastname: Moribayashi
authors.forename: C
authors.initials: C
authors.lastname: Kudou
authors.forename: Y
authors.initials: Y
authors.lastname: Hara
authors.forename: Y
authors.initials: Y
authors.lastname: Nakazawa
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: S
authors.initials: S
authors.lastname: Onizuka
mesh_terms: D000328:Adult; D000818:Animals; D016587:Antimutagenic Agents / Q000737:chemistry*; D001711:Biotransformation; D002417:Cattle; D004032:Diet; D005260:Female; D005399:Fishes; D006801:Humans; D008460:Meat; D009152:Mutagenicity Tests; D018515:Plant Leaves / Q000737:chemistry*; D013662:Tea; D016482:Urinalysis
chemical_list: D016587:Antimutagenic Agents; D013662:Tea