Trichoderma longibrachiatum infection in a pediatric patient with aplastic anemia.
Trichoderma longibrachiatum infection of the skin in an 11-year-old child with severe aplastic anemia and prolonged neutropenia is reported. The patient received systemic antifungal therapy and underwent bone marrow transplantation. To our knowledge, this is the first description of T. longibrachiatum infection in a pediatric patient. It also is the first case successfully treated with medical therapy. A review of the literature suggests that Trichoderma spp. are recognized as human pathogens with increasing frequency, particularly for immunocompromised patients, and should be considered in the differential diagnosis of fungal infections in the pediatric population.
Munoz
F M
FM
Department of Pediatrics, Baylor College of Medicine, and Pathology Laboratories, Houston, Texas 77030, USA.
Demmler
G J
GJ
Travis
W R
WR
Ogden
A K
AK
Rossmann
S N
SN
Rinaldi
M G
MG
D000666:Amphotericin B / Q000627:therapeutic use; D000741:Anemia, Aplastic / Q000150:complications*; D000935:Antifungal Agents / Q000627:therapeutic use; D002648:Child; D003881:Dermatomycoses / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D008297:Male; D012867:Skin / Q000382:microbiology; D014242:Trichoderma / Q000302:isolation & purification*
D000935:Antifungal Agents; D000666:Amphotericin B