[Cytokines and renal injury].
Cytokines play an important role in most physiological and pathological processes. In this note the authors review recent literature data about cytokines in mediating renal inflammatory diseases. These molecules are involved in every phase of inflammatory injury induce expression of MHC class II and adhesion molecules on renal cells, synthesis of chemoattractants; they are also involved in leukocyte localization and play a role in the induction of cell proliferation and the accumulation of extracellular matrix. The disturbances of the cytokine network may lead to inflammatory kidney disease that could be treated by novel therapeutic agents like anticytokine antibodies.
Amoroso
A
A
Departimento di Medicina Clinica, Università degli Studi di Roma La Sapienza, Roma.
Guido
F
F
Cossu
M F
MF
Afeltra
A
A
D000818:Animals; D016207:Cytokines / Q000009:adverse effects*; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology
D016207:Cytokines