title: [Vertical transmission of human immunodeficiency virus: six years of development 1987-1992)].
abstract: BACKGROUND
  According to World Health Organization estimates, from the beginning of the epidemics to the end of 1994, the number of children infected by human immunodeficiency virus (HIV) was 1.5 million. This paper describes the evolution of some clinical and epidemiologic characteristics of vertically transmitted HIV infection.
  
  
  METHODS
  All children born to HIV-infected mothers who delivered at a university hospital in Barcelona, Spain, between 1987 and 1992, were included in the study. Rates of HIV vertical transmission, HIV infection incidence and mortality due to HIV were estimated, and trends for the study period analyzed. Odds ratios were used to assess associations between variables.
  
  
  RESULTS
  192 newborns were identified and allocated, with respect to the year of birth, in three cohorts of 71, 58 and 63 children. Overall HIV vertical transmission rate was 16.5% and did not differ between cohorts. Infection incidence density rates increased over time (0.2, 4.9 and 8.1 cases/100 child-years, respectively; p = 0.016), while incubation periods decreased significantly (248, 103 and 114 days; p = 0.0004). There were no changes in mortality density rates (2.2 deaths/100 child-years). Regarding mothers' characteristics, a significant temporal trend (p < 0.001) for being older at delivery, belonging to the heterosexual transmission group and having symptomatic infection was observed over time.
  
  
  CONCLUSIONS
  Certain clinical and epidemiologic aspects of HIV vertical transmission have changed over time, however the number of new cases has remained fairly constant. In our setting, both early diagnosis and clinical management of these children have improved, but primary prevention for HIV vertical transmission has not been effective. Better counselling for HIV-infected women of childbearing age is needed.
authors.affiliation: Unidad Integrada de Pediatría, Hospital Clínic i Provincial-Hospital Sant Joan de Déu, Barcelona.
authors.forename: C
authors.initials: C
authors.lastname: Fortuny Guasch
authors.forename: E
authors.initials: E
authors.lastname: Sánchez Ruiz
authors.forename: O
authors.initials: O
authors.lastname: Coll Escursell
authors.forename: R
authors.initials: R
authors.lastname: Jiménez González
mesh_terms: D002648:Child; D002675:Child, Preschool; D015658:HIV Infections / Q000453:epidemiology / Q000635:transmission*; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical / Q000706:statistics & numerical data; D013030:Spain / Q000453:epidemiology