title: [Preventive program of birth defects: incidence of anencephaly in Maracaibo, Venezuela. 1993-1996 period].
abstract: Incidence of anencephaly in the State of Zulia, and specifically in the Eastern Coast of Lake Maracaibo, an oil exploitation area, has been declared high since the beginning of the 80's, coincident with the generalized use of ultrasound as a diagnostic tool for fetal evaluation. Through the Birth Defects Preventive Program, established at the Hospital Chiquinquirá in Maracaibo, we have developed a fourfold strategy for the study of birth defects: i) analysis of more than 32,332 ultrasound evaluations within the Ultrasound Service, between 1993 and 1996, ii) a case-control malformation registry beginning in 1995, iii) a study of malformed stillbirths at the Pathology Service, observed after 4232 deliveries within this hospital, and iv) a registry of over 638 mothers with high risk pregnancy for fetal defects detected at the prenatal clinic and carried out at the Perinatal Medical Genetics Service. As a reference population we study 345 medical histories obtained from the Medical Genetics and Prenatal Diagnostic Service at Hospital Coromoto, and oil companies related medical facility. This approach has led us to conclude that the incidence of anencephaly in the State of Zulia is 0.75/1000, significantly similar to that expected for most populations.
authors.affiliation: Servicio de Medicina Genética Perinatal, Hospital Chiquinquirá. Maracaibo, Venezuela.
authors.forename: H
authors.initials: H
authors.lastname: Moreno-Fuenmayor
authors.forename: V
authors.initials: V
authors.lastname: Valera
authors.forename: L
authors.initials: L
authors.lastname: Socorro-Candanoza
authors.forename: A
authors.initials: A
authors.lastname: Bracho
authors.forename: M
authors.initials: M
authors.lastname: Herrera
authors.forename: Z
authors.initials: Z
authors.lastname: Rodríguez
authors.forename: E
authors.initials: E
authors.lastname: Concho
mesh_terms: D000757:Anencephaly / Q000453:epidemiology* / Q000517:prevention & control; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D015397:Program Evaluation; D014687:Venezuela / Q000453:epidemiology