Acute bacterial peritonitis: permeability of cephalosporins in the peritoneal cavity.
Acute bacterial peritonitis is a common surgical disease treated with fluid resuscitation, surgery and antibiotics. The choice and use of antibiotics is an important supplement of therapy. Cephalosporins are among the most frequently used drugs for this condition. Although there is evidence that these agents reach the peritoneal cavity under normal conditions, no data are available regarding their delivery and concentration during acute secondary bacterial peritonitis. In order to determine the effectiveness of these agents in such cases, we studied the diffusion of three generations of cephalosporins--cefazolin, cefonicid and cefotaxime--into the peritoneal cavity during controlled bacterial peritonitis in rats. Our results show that all three drugs reached therapeutic concentrations in the peritoneal fluid; the highest concentration was obtained by the third-generation cefotaxime.
Eyal
A
A
Department of Surgery B, Rabin Medical Center, Petah Tikva, Israel.
Greif
F
F
Shalit
I
I
Lelcuk
S
S
D000208:Acute Disease; D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy*; D002437:Cefazolin / Q000493:pharmacokinetics*; D015790:Cefonicid / Q000493:pharmacokinetics*; D002439:Cefotaxime / Q000493:pharmacokinetics*; D002511:Cephalosporins / Q000493:pharmacokinetics*; D004353:Drug Evaluation, Preclinical; D016903:Drug Monitoring; D010529:Peritoneal Cavity; D010538:Peritonitis / Q000188:drug therapy*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
D002511:Cephalosporins; D015790:Cefonicid; D002437:Cefazolin; D002439:Cefotaxime