Study of an outbreak of cefoxitin-resistant Klebsiella pneumoniae in a general hospital.
During a 3-month period, six Klebsiella pneumoniae isolates resistant to cefoxitin and penicillin-inhibitor combinations were derived from patients in the intensive care unit of a hospital in Athens, Greece. Enterobacterial repetitive intergenic consensus PCR and pulsed-field gel electrophoresis provided evidence of the clonal origin of the isolates. Conventional techniques and ribotyping were inadequate in proving that the isolates were related. Resistance was due to a plasmidic class C beta-lactamase.
Gazouli
M
M
Department of Bacteriology, Hellenic Pasteur Institute, Athens, Greece.
Kaufmann
M E
ME
Tzelepi
E
E
Dimopoulou
H
H
Paniara
O
O
Tzouvelekis
L S
LS
D015373:Bacterial Typing Techniques; D002440:Cefoxitin / Q000494:pharmacology*; D018550:Cephalosporin Resistance / Q000235:genetics; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology*; D004196:Disease Outbreaks; D004352:Drug Resistance, Microbial; D006115:Greece / Q000453:epidemiology; D006769:Hospitals, General; D006801:Humans; D007362:Intensive Care Units; D007710:Klebsiella Infections / Q000453:epidemiology / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000145:classification / Q000187:drug effects* / Q000235:genetics; D016133:Polymerase Chain Reaction; D011815:R Factors; D001618:beta-Lactamases / Q000235:genetics
D002440:Cefoxitin; D001618:beta-Lactamases