title: Abnormalities of collagen cross-linkage in posterior communicating artery aneurysms: a preliminary study.
abstract: The collagen of tissues submitted to mechanical load (i.e. arterial wall) is characterised by the presence of intermolecular covalent cross-links (hydroxylysyl pyridinoline or pyridinoline: PYD; and lysyl-pyridinoline or deoxypyridinoline: DPD) which stabilise the molecular structure. In this preliminary study we look for quantitative or qualitative alterations of collagen cross-linkage in intracranial aneurysms of posterior communicating artery (PCoA) which may be considered a site of elective weakening in the intracranial arterial circulation, being one of the most frequent locations of intracranial aneurysms and of so called "infundibular widening'. We analysed the collagen cross-linkage in 6 autopsy samples of intracranial arterial segments of the Circle of Willis which were removed from patients whose cause of death was other than cerebral hemorrhage, and in 6 samples of intracranial PCoA aneurysms obtained at surgery. The analysis of cross-links showed that there was no significant difference in collagen and cross-link content between autopic and aneurysmatic samples except for PCoA. In autoptic nonaneurysmatic samples of PCoA a lower content of PYD than in internal carotid artery (ICA) and a lower content of DPD than in all other arterial segments has been demonstrated; moreover a lower content of cross-links (DPD + PYD/ Collagen) was evident in nonaneurysmatic PCoA samples when compared to other segments (ICA and Anterior Communicating Artery). On the other hand, the mean content of DPD was significantly lower in PCoA aneurysms than in nonaneurysmatic samples of the artery and moreover, a significantly low content of cross-links (DPD + PYD/Collagen) is overemphasised in PCoA aneurysms, suggesting that the peculiar lower content of DPD in PCoA arteries may be considered the expression of minor resistance of the arterial wall at this site, and may be related to the higher incidence of aneurysms or infundibular widening of this arterial segment.
authors.affiliation: Department of Neurosurgery, IRCCS Policlinico S. Matteo, Pavia, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Gaetani
authors.forename: V
authors.initials: V
authors.lastname: Grazioli
authors.forename: F
authors.initials: F
authors.lastname: Tancioni
authors.forename: E
authors.initials: E
authors.lastname: Casari
authors.forename: F
authors.initials: F
authors.lastname: Tartara
authors.forename: R
authors.initials: R
authors.lastname: Rodriguez y Baena
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000032:analysis; D002941:Circle of Willis / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D003094:Collagen / Q000737:chemistry* / Q000378:metabolism; D003432:Cross-Linking Reagents / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D002532:Intracranial Aneurysm / Q000378:metabolism*; D008875:Middle Aged; D010865:Pilot Projects
chemical_list: D000596:Amino Acids; D003432:Cross-Linking Reagents; C015484:pyridinoline; C036020:deoxypyridinoline; D003094:Collagen