Effects of acute prolonged exercise on-serum and LDL oxidation and antioxidant defences.
We investigated the acute effects of long-distance running on oxidation of lipids and antioxidant functions in LDL and serum. Eight trained male runners who participated in a 31-km run and 22 male keep-fit runners who participated in a marathon run were enrolled into the study. Venous blood samples were taken before and immediately after the exercise. There were no changes in LDL diene conjugation (LDL-DC) or LDL antioxidant potential (LDL-TRAP) during the exercises. Serum (S-) TRAP and S-alpha-tocopherol rose during the 31-km run (by 22%, p = .0005, and by 29%, p = .011, respectively), and during the marathon (by 16%, p = .0014, and by 7%, p = .031, respectively). S-DC rose during the 31-km run (by 9%, p = .0026), but not during the marathon (p = .14). Preexercise and postexercise S-alpha-tocopherol correlated positively with pre and postexercise S-TRAP in the marathon run (r = .473, 95% CI 0.064 to 0.746, and r = .524, 95% CI 0.131 to 0.774, respectively). Thus, the paradoxical exercise-associated increase in S-TRAP is, at least in part, explained by a simultaneous rise in S-alpha-tocopherol concentration. However, acute exercise does not change LDL-DC or LDL-TRAP concentrations.
Vasankari
T J
TJ
Paavo Nurmi Center, Sports Medical Research Unit, Vierumäki, Finland.
Kujala
U M
UM
Vasankari
T M
TM
Vuorimaa
T
T
Ahotupa
M
M
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D010084:Oxidation-Reduction; D010545:Peroxides / Q000378:metabolism; D010807:Physical Endurance; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000097:blood; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood
D000975:Antioxidants; D008077:Lipoproteins, LDL; D010545:Peroxides; D014801:Vitamin A; D014451:Ubiquinone; D014810:Vitamin E; C049375:perhydroxyl radical; C026663:ubiquinol-10