Hemostasis parameters during ovarian stimulation for in vitro fertilization: results of a prospective study.
OBJECTIVE
To evaluate the effect of IVF-ET on the hemostatic system.


METHODS
Prospective clinical study.


METHODS
Apparently healthy age-matched women of the hospital staff at various stage of the menstrual cycle.


METHODS
Twenty-five women involved in a IVF-ET program at the Department of Obstetrics and Gynecology, Montpellier University Hospital.


METHODS
Twenty-six hemostasis parameters evaluated repeatedly in patients undergoing IVF-ET.


METHODS
Blood cell-dependent hemostasis parameters and plasmatic coagulation factors, determined at pituitary desensitization, maximal E2 level, and P plateau.


RESULTS
Activation of the hemostatic system is evidenced at the P plateau, when D-dimers and fragments 1 + 2 of the prothrombin levels rose dramatically. At E2 peak, no significant modification of hemostasis markers was noted.


CONCLUSIONS
The present results indicate that ovarian hyperstimulation may induce hemostasis activation at the P plateau. The role of supraphysiologic sex hormone levels on the hemostatic system requires further investigation.
Biron
C
C
University Hospital, Montpellier, France.
Galtier-Dereure
F
F
Rabesandratana
H
H
Bernard
I
I
Aguilar-Martinez
P
P
Schved
J F
JF
Hedon
B
B
D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D006487:Hemostasis; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000097:blood*; D011446:Prospective Studies; D016897:Respiratory Burst; D013925:Thromboplastin / Q000032:analysis
D004958:Estradiol; D013925:Thromboplastin