title: Preparation of radioactive lead complexes utilizing Chelex methodology.
abstract: The use of Chelex resin for the synthesis of radioactive lead complexes has been explored. The process involved immobilization of 203Pb on the resin and subsequent elution of complexed lead by chelating agents. 203Pb complexes derived from meso- and racemic dimercaptosuccinic acid (meso-DMSA, rac-DMSA) were prepared and assessed for stability in vitro.
authors.affiliation: Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205-2179, USA.
authors.forename: S Z
authors.initials: SZ
authors.lastname: Lever
authors.forename: D L
authors.initials: DL
authors.lastname: Stricklin
mesh_terms: D002614:Chelating Agents; D002855:Chromatography, Thin Layer; D004355:Drug Stability; D007475:Ion Exchange Resins; D007553:Isotope Labeling / Q000379:methods*; D007856:Lead Radioisotopes / Q000737:chemistry*; D011137:Polystyrenes; D011145:Polyvinyls; D013237:Stereoisomerism; D004113:Succimer / Q000737:chemistry*
chemical_list: D002614:Chelating Agents; D007475:Ion Exchange Resins; D007856:Lead Radioisotopes; D011137:Polystyrenes; D011145:Polyvinyls; C006960:chelex; D004113:Succimer