title: Absence of microsatellite instability during the progression of chronic myelocytic leukemia.
abstract: Microsatellites are highly polymorphic, short-tandem repeat sequences dispersed throughout the genome. To test the occurrence of genetic instability in the progression of chronic myelocytic leukemia (CML), we studied microsatellite instability (MSI) in 17 patients with CML. The DNAs from both chronic phase and blast crisis were analyzed at 10 loci. No MSI was observed in any of the 17 cases of blast crisis. These results indicate that MSI is rare and is not associated with progression to blast crisis in most cases of CML.
authors.affiliation: Department of Medicine, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA.
authors.forename: N
authors.initials: N
authors.lastname: Mori
authors.forename: S
authors.initials: S
authors.lastname: Takeuchi
authors.forename: T
authors.initials: T
authors.lastname: Tasaka
authors.forename: S
authors.initials: S
authors.lastname: Lee
authors.forename: S
authors.initials: S
authors.lastname: Spira
authors.forename: D
authors.initials: D
authors.lastname: Ben-Yehuda
authors.forename: H
authors.initials: H
authors.lastname: Mizoguchi
authors.forename: G
authors.initials: G
authors.lastname: Schiller
authors.forename: H P
authors.initials: HP
authors.lastname: Koeffler
mesh_terms: D001752:Blast Crisis / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics; D018450:Disease Progression; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000473:pathology; D018895:Microsatellite Repeats / Q000235:genetics*