Interferon expression by B cells.
Interferons have effects on many facets of immune system development, maturation, and function. B cells are a target for the interferons, causing alterations in cell differentiation and gene expression. However, production of interferons by B cells has not been widely studied. In this review I will discuss the limited literature on B-cell interferon production. In addition I will describe results obtained from a transgenic model in which interferon-gamma production has been targeted to the B-cell compartment. In this animal, B-cell development is blocked, reflecting the deleterious effects that aberrant expression of interferon can have on this cell population.
Young
H A
HA
Laboratory of Experimental Immunology, National Cancer Institute-FCRDC, Frederick, Maryland 21702-1201, USA.
D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism*; D015139:Blotting, Southern; D001853:Bone Marrow / Q000737:chemistry / Q000378:metabolism; D005786:Gene Expression Regulation / Q000235:genetics*; D016898:Interferon-alpha / Q000378:metabolism; D007371:Interferon-gamma / Q000378:metabolism; D007372:Interferons / Q000378:metabolism* / Q000494:pharmacology; D051379:Mice; D008822:Mice, Transgenic; D012333:RNA, Messenger / Q000235:genetics
D016898:Interferon-alpha; D012333:RNA, Messenger; D007371:Interferon-gamma; D007372:Interferons