title: Nuclear architecture and the induction of chromosomal aberrations.
abstract: Progress in fluorescence in situ hybridization, three dimensional microscopy and image analysis has provided the means to study the three-dimensional structure and distribution of chromosome territories within the cell nucleus. In this contribution, we summarize the present state of knowledge of the territorial organization of interphase chromosomes and their topological relationships with other macromolecular domains in the human cell nucleus, and present data from computer simulations of chromosome territory distributions. On this basis, we discuss models of chromosome territory and nuclear architecture and topological consequences for the formation of chromosome exchanges.
authors.affiliation: Institut für Angewandte Physik, Universität Heidelberg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Cremer
authors.forename: C
authors.initials: C
authors.lastname: Münkel
authors.forename: M
authors.initials: M
authors.lastname: Granzow
authors.forename: A
authors.initials: A
authors.lastname: Jauch
authors.forename: S
authors.initials: S
authors.lastname: Dietzel
authors.forename: R
authors.initials: R
authors.lastname: Eils
authors.forename: X Y
authors.initials: XY
authors.lastname: Guan
authors.forename: P S
authors.initials: PS
authors.lastname: Meltzer
authors.forename: J M
authors.initials: JM
authors.lastname: Trent
authors.forename: J
authors.initials: J
authors.lastname: Langowski
authors.forename: T
authors.initials: T
authors.lastname: Cremer
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000235:genetics / Q000528:radiation effects / Q000648:ultrastructure*; D002869:Chromosome Aberrations / Q000235:genetics; D002875:Chromosomes / Q000235:genetics / Q000528:radiation effects / Q000648:ultrastructure; D003198:Computer Simulation; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008953:Models, Anatomic; D008957:Models, Genetic