title: New dimeric aporphine alkaloids and cytotoxic constituents of Hernandia nymphaeifolia.
abstract: Three minor new dimeric aporphine alkaloids, oviisocorydine (1), ovihernangerine (2), and oxohernandaline (3), along with four known alkaloids, (+)-hernandaline, (+)-thallcarpine, (+)-N-methylovigerine, and N-methylcorydaldine, and five known lignans, (+)-epimagnolin, (+)-epiaschantin, (+)-epiyangambin, (-)-deoxypodophyllotoxin, and (-)-yatein, have been additionally isolated from the trunk bark of Hernandia nymphaeifolia. The structures of these compounds were elucidated by spectroscopic methods. Among forty-four isolates obtained till now, nine compounds, hernandonine (4), hernanymphine (5), demethylsonodione (6), (+)-ovigerine (7), (+)-N-methylovigerine (8), N-formyldehydroovigerine (9), 4-methoxyoxohernandaline (10), (-)-deoxypodophyllotoxin (11), and (-)-yatein (12) showed significant cytotoxic activities (ED50 values < 1 microgram/ml) against P-388, KB16, A549, and HT-29 cell lines.
authors.affiliation: Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan, Republic of China.
authors.forename: J J
authors.initials: JJ
authors.lastname: Chen
authors.forename: T
authors.initials: T
authors.lastname: Ishikawa
authors.forename: C Y
authors.initials: CY
authors.lastname: Duh
authors.forename: I L
authors.initials: IL
authors.lastname: Tsai
authors.forename: I S
authors.initials: IS
authors.lastname: Chen
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D010944:Plants / Q000737:chemistry; D013624:Taiwan; D014407:Tumor Cells, Cultured
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic