title: Pattern of inhalation exposure: blood levels and acute subnarcotic effects of toluene and acetone in rats.
abstract: Solvent blood concentrations and subnarcotic effects (inhibition of electrically evoked seizures) were measured in rats exposed to constant or fluctuating air concentrations of toluene or acetone. A 4 hour exposure of resting rats to toluene at an air concentration of 1 and 2 mg/l, or to acetone at 4 and 10 mg/l, led to blood levels of 6.7 and 12.8 mg/l of toluene, or 183 and 520 mg/l of acetone: seizure inhibition amounted to 18% and 40+, or 10% and 50%, respectively. Blood level and effect attained 1/2 of the final values after 40 min and 60 min of exposure to 2 mg/l toluene, respectively, and dropped to 1/2 70 min and 90 min after exposure cessation: respective values for acetone 10 mg/l were 80 and 120 min, and more than 4 hours. A steep rise and a rapid drop was characteristic also for the course of blood level and effect during an exposure to fluctuating concentrations of toluene: ten minute fivefold jump in the air concentration induced a shortlasting seizure inhibition by more than 80%; the curves for acetone were flat.
authors.affiliation: Centre of Industrial Hygiene and Occupational Diseases, National Institute of Public Health, Prague, Czech Republic.
authors.forename: E
authors.initials: E
authors.lastname: Frantík
authors.forename: L
authors.initials: L
authors.lastname: Vodicková
authors.forename: M
authors.initials: M
authors.lastname: Hornychová
authors.forename: M
authors.initials: M
authors.lastname: Nosek
mesh_terms: D000096:Acetone / Q000633:toxicity*; D000280:Administration, Inhalation; D000818:Animals; D001822:Body Burden; D004305:Dose-Response Relationship, Drug; D008297:Male; D008954:Models, Biological; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced; D012997:Solvents / Q000633:toxicity*; D013997:Time Factors; D014050:Toluene / Q000633:toxicity*
chemical_list: D012997:Solvents; D000096:Acetone; D014050:Toluene