[The physiological characteristics of the antioxidant properties of Lipin in bronchial asthma in children].
In children of 4-7 years old with bronchial asthma (BA) has been studied the values of lipid peroxidation, antioxidant status and some others in blood plasma and erythrocytes without and with the use of new drug Lipin. It was shown that in children with BA the malondialdehyde concentration increased, the superoxydedismutase activity decreased, the NAD concentration increased, and the ratio of superoxidedismutase/malondialdehyde greatly decreased in comparison with normal children. The use of Lipin led to diminuation of lipid peroxidation, to marked increase of superoxidedismutase activity, to decrease of NAD concentration, and to significant increase of superoxidedismutase/malondialdehyde ratio. These results were indicated on the expressed antioxidant properties of Lipin in children's with BA.
Tymchenko
O H
OH
Seredenko
M M
MM
Portnychenko
V I
VI
Babko
S O
SO
Velychko
M I
MI
Tsvietkova
K V
KV
D000280:Administration, Inhalation; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D000975:Antioxidants / Q000008:administration & dosage*; D001249:Asthma / Q000097:blood / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D004337:Drug Carriers; D004341:Drug Evaluation; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008081:Liposomes; D009930:Organic Chemicals
D000890:Anti-Infective Agents; D000975:Antioxidants; D004337:Drug Carriers; D008081:Liposomes; D009930:Organic Chemicals; C088310:lipine