Allelic variants of human calcitonin receptor in the Japanese population.
Evidence from cDNA cloning has shown that calcitonin receptors (CTRs) have seven potential transmembrane domains. In this study, structural analysis of CTRs from ten cultured human tumor cell lines and 117 human blood samples demonstrated allelic variants at the 1377th nucleotide in intracellular domain 4, expressing either proline or leucine as the 463rd amino acid. It was found that the variant with proline at this site was the more prevalent type of CTR among the Japanese population.
Nakamura
M
M
Second Department of Pathology, Wakayama Medical College, Japan.
Zhang
Z Q
ZQ
Shan
L
L
Hisa
T
T
Sasaki
M
M
Tsukino
R
R
Yokoi
T
T
Kaname
A
A
Kakudo
K
K
D000483:Alleles; D002460:Cell Line; D017931:DNA Primers; D014644:Genetic Variation; D006801:Humans; D007564:Japan; D007930:Leucine; D008961:Models, Structural; D016133:Polymerase Chain Reaction; D011392:Proline; D011487:Protein Conformation; D018003:Receptors, Calcitonin / Q000737:chemistry / Q000235:genetics*; D014407:Tumor Cells, Cultured
D017931:DNA Primers; D018003:Receptors, Calcitonin; D011392:Proline; D007930:Leucine