8-OH-DPAT and male rat sexual behavior: partial blockade by noradrenergic lesion and sexual exhaustion.
As previously shown, the 5-HT1A agonist 8-OH-DPAT is a potent facilitator of male rat copulatory behavior in both sexually experienced and sexually exhausted male rats. The basis of this facilitation is still not clear. Therefore, the purpose of the present study was to determine whether 8-OH-DPAT-induced sexual-behavior facilitation could be counteracted by lesioning the NA system with the noradrenergic neurotoxin DSP4. In NA-lesioned, sexually experienced, non-exhausted rats, the facilitatory effects of 8-OH-DPAT on the number of mounts and the postejaculatory interval were reduced, the effect on the intromission latency disappeared, while the percentage of copulating rats was not significantly altered. In sexually exhausted rats bearing a lesion of the NA system, the facilitatory effects of 8-OH-DPAT on the percentage of copulating rats was blocked. Data are discussed on the basis of the interactions between the noradrenergic and serotonergic systems in the mediation of the facilitatory effect of 8-OH-DPAT in sexually exhausted and non-exhausted rats.
Fernández-Guasti
A
A
Departamento de Farmacología y Toxicología, CINVESTAV, México D.F., México.
Rodríguez-Manzo
G
G
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000818:Animals; D001596:Benzylamines; D001923:Brain Chemistry / Q000187:drug effects; D003307:Copulation / Q000187:drug effects; D004542:Ejaculation / Q000187:drug effects; D008297:Male; D009498:Neurotoxins; D009638:Norepinephrine / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013563:Sympathectomy, Chemical; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology*
D001596:Benzylamines; D009498:Neurotoxins; D017366:Serotonin Receptor Agonists; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; C012102:DSP 4; D009638:Norepinephrine