Non-traditional risk factors for atherosclerosis in high risk children.
Non-traditional risk factors for atherosclerosis were examined in children whose fathers suffered from myocardial infarction up to age 48. Factors examined were hyperinsulinemia, insulin resistance, lipoprotein(a) [Lp(a)], fibrinogen, cardiovascular hyperreactivity, and autonomic nervous system dysfunction. Hyperinsulinemia was present in five cases (9%) and hypoinsulinemia in two. Insulin output following glucose load was significantly higher in obese children compared with controls. There was an increase in Lp(a) alone in 14 cases (24%) and with low density lipoprotein in 6 cases. Increased fibrinogen and positive correlation with insulin abnormality was present in 29% (76% females) (P >0.02). Cardiac hyperreactivity (increased systolic blood pressure) was present in 9% and increased blood pressure and pulse rate in 17%. Holter monitoring pattern was sympathetic in 39% and parasympathetic in 47% of cases. Thus a number of non-traditional risk factors were found to be higher than normal in a relatively large number of children at high risk for atherosclerosis, with 25 children having more than three risk factors.
Blieden
L C
LC
Institute of Cardiology, Schneider Children's Medical Center of Israel, Petah Tikva.
Kuberger
N
N
Goez
R
R
Abramov
N
N
Laron
Z
Z
Weizman
A
A
Gil-Ad
I
I
D000293:Adolescent; D000328:Adult; D001161:Arteriosclerosis / Q000209:etiology*; D001342:Autonomic Nervous System Diseases / Q000150:complications*; D016022:Case-Control Studies; D002648:Child; D015716:Electrocardiography, Ambulatory; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications*; D006951:Hyperlipoproteinemias / Q000150:complications*; D017379:Hypertrophy, Left Ventricular / Q000150:complications*; D007333:Insulin Resistance; D017270:Lipoprotein(a); D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology; D012307:Risk Factors; D013927:Thrombosis / Q000150:complications*
D017270:Lipoprotein(a); D005340:Fibrinogen