[Serotonin-reactive neurons of the neocortex].
In the course of study performed on Wistar line rats using light and electron microscopy it was found that brain serotoninergic system damage by the selective neurotoxin of 5,7 dihydroxytryptamine leads to degenerative changes in certain pyramidal neurons of the motor cortex superficial layers. Deep layers pyramid neurons acquire the signs of functional activity increase with the appearance of intranuclear inclusions. The results obtained are discussed with taking to consideration the impact of serotoninergic system damage on the neuropsychic diseases pathogenesis.
Otellin
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Korzhevskiĭ
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D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D003891:Desipramine / Q000494:pharmacology; D008297:Male; D008854:Microscopy, Electron; D009474:Neurons / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000172:deficiency / Q000378:metabolism*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013997:Time Factors
D018759:Adrenergic Uptake Inhibitors; D017366:Serotonin Receptor Agonists; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D003891:Desipramine; D009638:Norepinephrine