Bladder cancer incidence in arylamine workers.
Cancer incidence was investigated in a cohort of 700 workers employed at a Connecticut chemical plant between mid-1965 and 1989. The plant produced a variety of chemicals, including arylamines such as dichlorobenzidine (DCB), o-dianisidine, o-tolidine, but not benzidine. Benzidine production ceased prior to mid-1965. The principal finding was a statistically significant increase in the standardized incidence ratio (SIR) for bladder cancer in men (SIR = 8.3; confidence interval, 3.3 to 17.0). Based on an exposure classification system developed by a panel of former and current employees, the observed association between bladder cancer cases and exposure to arylamines increased with increasing exposure (SIRs = 0.0, 5.5, 16.4, for none, low, or moderate levels of exposure, respectively). Smoking probably contributed to the bladder cancer risk, as all case subjects were known to be current or former cigarette smokers.
Ouellet-Hellstrom
R
R
Analytic Sciences Group, SRA Technologies, Falls Church, Va. 22042, USA.
Rench
J D
JD
D000328:Adult; D000368:Aged; D000588:Amines / Q000009:adverse effects*; D016022:Case-Control Studies; D002617:Chemical Industry; D003237:Connecticut / Q000453:epidemiology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology*; D016016:Proportional Hazards Models; D012907:Smoking / Q000009:adverse effects; D016019:Survival Analysis; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology*
D000588:Amines