title: Generalized prepubertal periodontitis. A report of 4 cases with the immunological findings.
abstract: The clinical and immunological data from 4 patients with generalized prepubertal periodontitis are presented. The peripheral blood neutrophil chemotaxis was measured using zymosan activated sera as the chemoattractant. All of the 4 patients have shown depressed neutrophil chemotaxis compared to those of the healthy controls. Peripheral blood lymphocyte subpopulations were analysed by double-coloured flow cytometry using monoclonal antibodies for the receptors CD2, CD3, CD4, CD8, CD19, CD29, CD45RA+, 34,29dK, CD56. CD11b/CD18. Lymphocytes bearing CD3 receptors showed a significant decrease compared to those of the controls. Natural killer cells were lowered in 3 of the 4 cases. All of the patients showed a higher increase in CD11b/CD18 expression. The evaluation of CD11b/CD18 receptor in peripheral blood leukocytes may be of help explaining the rôle of neutrophils in the pathogenesis of the disease.
authors.affiliation: Department of Periodontology, School of Dentistry, University of Istanbul, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Firatli
authors.forename: N
authors.initials: N
authors.lastname: Gürel
authors.forename: A
authors.initials: A
authors.lastname: Efeoğlu
authors.forename: I
authors.initials: I
authors.lastname: Cebeci
mesh_terms: D000293:Adolescent; D010520:Aggressive Periodontitis / Q000097:blood / Q000276:immunology*; D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000276:immunology; D018821:CD18 Antigens / Q000276:immunology; D017252:CD3 Complex / Q000276:immunology; D016516:CD4-CD8 Ratio; D002634:Chemotaxis, Leukocyte; D002648:Child; D005260:Female; D005434:Flow Cytometry; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology; D016177:Macrophage-1 Antigen / Q000276:immunology; D008297:Male; D009504:Neutrophils / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D018821:CD18 Antigens; D017252:CD3 Complex; D006684:HLA-DR Antigens; D016177:Macrophage-1 Antigen