Fab' fragments of a mAb to a member of family 2 of trans-sialidases of Trypanosoma cruzi block trypanosome invasion of host cells and neutralize infection by passive immunization.
Villalta
F
F
Division of Biomedical Sciences, Meharry Medical College, Nashville, Tennessee 37208, USA.
Smith
C M
CM
Burns
J M
JM
Chaudhuri
G
G
Lima
M F
MF
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000913:Antibodies, Protozoan / Q000276:immunology; D000953:Antigens, Protozoan / Q000276:immunology; D014355:Chagas Disease / Q000276:immunology*; D006023:Glycoproteins / Q000276:immunology*; D006321:Heart / Q000469:parasitology; D007116:Immunization, Passive; D007140:Immunoglobulin Fab Fragments / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009439:Neuraminidase / Q000276:immunology*; D014349:Trypanosoma cruzi / Q000201:enzymology / Q000276:immunology* / Q000472:pathogenicity
D000911:Antibodies, Monoclonal; D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D006023:Glycoproteins; D007140:Immunoglobulin Fab Fragments; C069715:trans-sialidase; D009439:Neuraminidase