title: [Impairment of myocardial perfusion reserve in microvascular angina (syndrome X): assessment by 99mTc-MIBI-SPECT].
abstract: OBJECTIVE
  In 22 patients with typical chest pain and normal coronary arteries (microvascular angina, syndrome X) 99mTc-MIBI-SPECT was examined in regard to assess impairment of myocardial perfusion reserve.
  
  
  METHODS
  The study was performed with 99mTc-MIBI-SPECT at rest and under vasodilation with dipyridamole. The findings were compared with a normal database. A normal perfusion reserve was said to be an increase > 20% of the 99mTc-MIBI-activity.
  
  
  RESULTS
  In 2/22 (9%) of the patients the perfusion reserve lay > 20% i.e. 37%. In 91% of the patients a diminution or even decrease of the perfusion was to be seen. From these 9/22 (41%) of the patients showed a diminution of the 99mTc-MIBI-uptake by 6%. 1/22 patients had a decrease of the perfusion under vasodilation with dipyridamole i.e. a lower activity of 99mTc-MIBI by 13%
  
  
  CONCLUSIONS
  Vasodilation 99mTc-MIBI-SPECT offers good imaging quality and enables semi-quantitative assessment of myocardial perfusion reserve in patients with microvascular angina.
authors.affiliation: Abteilung für Kardiologie, Universitäts-Krankenhaus Eppendorf Hamburg, Deutschland.
authors.forename: K
authors.initials: K
authors.lastname: Langes
authors.forename: B
authors.initials: B
authors.lastname: Beuthien-Baumann
authors.forename: M
authors.initials: M
authors.lastname: Lübeck
authors.forename: C
authors.initials: C
authors.lastname: Fuchs
authors.forename: M A
authors.initials: MA
authors.lastname: Schneider
authors.forename: C
authors.initials: C
authors.lastname: Volk
authors.forename: C A
authors.initials: CA
authors.lastname: Nienaber
mesh_terms: D001794:Blood Pressure; D002637:Chest Pain; D004176:Dipyridamole; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000503:physiopathology; D006339:Heart Rate; D006801:Humans; D008297:Male; D017566:Microvascular Angina / Q000000981:diagnostic imaging*; D008875:Middle Aged; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D004176:Dipyridamole; D017256:Technetium Tc 99m Sestamibi