Transient hypertriglyceridemia of infancy.
A premature boy who had suffered from IRDS, bronchopulmonary dysplasia and retinopathy of prematurity developed massive hypertriglyceridemia (48.1 mmol/L) together with moderate hypercholesterolemia (12.6 mmol/L) at 5 months of age. Lipoprotein electrophoresis revealed a marked elevation of the level of the very low density lipoprotein fraction. There was a moderate decrease in the activity of a lipolytic enzyme, lipoprotein lipase (LPL). The child had neither liver or renal disorder nor any inflammatory disease. The hyperlipidemia disappeared spontaneously at the age of 3 years. The cause of the decreased LPL activity could not be established. A partial genetic deficiency in lipoprotein lipase appears the most likely explanation, since no signs of secondary lowering of LPL activity could be found.
Nilsson
A
A
Department of Paediatrics, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden.
Ortqvist
E
E
Lagercrantz
H
H
Nilsson-Ehle
P
P
Henter
J I
JI
D002675:Child, Preschool; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications; D015228:Hypertriglyceridemia / Q000201:enzymology; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008071:Lipoprotein Lipase / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D012075:Remission, Spontaneous
D008079:Lipoproteins, VLDL; D008071:Lipoprotein Lipase