[The dynamic biosynthesis of nicotinamide coenzymes from nicotinamide and nicotinic acid in rat tissues].
Dynamics of nicotinamide coenzyme biosynthesis in rat tissues has been studied systematically with previous injection of two main precursors nicotinic acid and nicotinamide (50 mg/100 g of weight. This process is characterized by exact tissue specificity. As a precursor of NAD-biosynthesis nicotinamide was used more intensively in the liver and brain tissues. In the mucous tissue of intestine nicotinic acid was utilized more intensively. An increase in the NADP+ content in tissues with high level of NAD+ biosynthesis is limited as a result of competition between these two processes for the intracellular ATP level.
Fedyk
M Ia
MIa
Velykyĭ
M M
MM
Zababurina
M L
ML
Oliiarnyk
O D
OD
D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009243:NAD / Q000096:biosynthesis*; D009249:NADP / Q000096:biosynthesis*; D009525:Niacin / Q000008:administration & dosage / Q000378:metabolism*; D009536:Niacinamide / Q000008:administration & dosage / Q000378:metabolism*; D009928:Organ Specificity; D051381:Rats; D013997:Time Factors
D009243:NAD; D009536:Niacinamide; D009525:Niacin; D009249:NADP