[Cell adhesion molecules on platelet].
Platelets are anucleated blood cells that play a fundamental role in the initiation of hemostasis. In addition to platelet adhesion to the extracellular matrix, aggregation or platelet-platelet interaction is a requisite event in hemostasis. Some glycoproteins on platelet membranes mediate adhesion platelets. The glycoprotein (GP) Ib/IX/V complex is important in platelet adhesion and the GPIIb/IIIa complex mediate platelet to platelet interaction. P-selectin is a member of the selectin family and is transferred from secretory granules to the surface of activated platelets. P-selectin may function to mediate the interaction between activated platelets and leucocytes. We reviewed structure, function, biological roles and clinical application of three platelet-associated adhesion molecules.
Ono
M
M
Department of Clinical Pathology, Iwate Medical University, Morioka.
Itoh
C
C
D000818:Animals; D000906:Antibodies / Q000627:therapeutic use; D015815:Cell Adhesion Molecules / Q000502:physiology; D006801:Humans; D019007:P-Selectin / Q000276:immunology / Q000502:physiology; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000502:physiology; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000502:physiology; D013927:Thrombosis / Q000209:etiology / Q000628:therapy
D000906:Antibodies; D015815:Cell Adhesion Molecules; D019007:P-Selectin; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D019038:Platelet Glycoprotein GPIb-IX Complex