title: Metabolic and pharmacokinetic considerations in the design of 2-phenyl substituted metyrapone derivatives: 2-methoxyphenylmetyrapone as a radioligand for functional diagnosis of adrenal pathology.
authors.affiliation: Department of Pharmacy, Chinese University of Hong Kong, Shatin.
authors.forename: L A
authors.initials: LA
authors.lastname: Damani
authors.forename: M
authors.initials: M
authors.lastname: Mitterhauser
authors.forename: I
authors.initials: I
authors.lastname: Zolle
authors.forename: G
authors.initials: G
authors.lastname: Lin
authors.forename: E
authors.initials: E
authors.lastname: Oehler
authors.forename: Y P
authors.initials: YP
authors.lastname: Ho
mesh_terms: D000307:Adrenal Gland Diseases / Q000000981:diagnostic imaging* / Q000201:enzymology; D000311:Adrenal Glands / Q000000981:diagnostic imaging / Q000201:enzymology; D000818:Animals; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D004791:Enzyme Inhibitors / Q000493:pharmacokinetics; D005260:Female; D008797:Metyrapone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D011849:Radioactive Tracers; D011877:Radionuclide Imaging; D051381:Rats; D017207:Rats, Sprague-Dawley; D013252:Steroid 11-beta-Hydroxylase / Q000037:antagonists & inhibitors
chemical_list: C102846:2-methoxyphenylmetyrapone; D004791:Enzyme Inhibitors; D011849:Radioactive Tracers; D013252:Steroid 11-beta-Hydroxylase; D008797:Metyrapone