[The role of the eicosanoids in the development of a postischemic shock reaction].
The role of eicosanoids as one of the main shock mediators was demonstrated in experiments anesthetized dogs with modeled postischemic shock using premedication with indometacin and/or quercetin. Preliminary administration of the eicosanoid biosynthesis inhibitors has prevented reperfusion hemodynamics disturbances during 3 hours after the beginning of an extremity reperfusion. The presented results confirm vascular endothelium injury in the investigated areas, which caused disbalance in the necessity-flow balance in working organs. Therefore, a damage in the endotheliocytes function is the first and, probably, a leading factor in development of the postischemic disturbances of circulation.
Zhukova
A V
AV
Sahach
V F
VF
D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D004285:Dogs; D015777:Eicosanoids / Q000502:physiology*; D006439:Hemodynamics / Q000187:drug effects; D006614:Hindlimb / Q000098:blood supply*; D007213:Indomethacin / Q000494:pharmacology; D007511:Ischemia / Q000150:complications* / Q000503:physiopathology; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology; D011794:Quercetin / Q000494:pharmacology; D015427:Reperfusion Injury / Q000150:complications / Q000503:physiopathology / Q000517:prevention & control; D012769:Shock / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D013997:Time Factors; D014111:Tourniquets
D016861:Cyclooxygenase Inhibitors; D015777:Eicosanoids; D016859:Lipoxygenase Inhibitors; D011794:Quercetin; D007213:Indomethacin