title: Epidemiology of poliomyelitis in Karachi, Pakistan: prospective studies during 1990-93.
abstract: Between October 1989 and September 1993, 245 cases of poliomyelitis visited the Department of Pediatrics, Civil Hospital Karachi, Pakistan. The majority of them were between 6 months and 2 years of age and the epidemic occurred during the hot season. The dominant serotype was polio type 1. All of the polioviruses isolated from the patients were wild type. Virological studies also disclosed that enteroviruses other than polioviruses were prevalent among healthy children as well as diarrheal and polio patients. Serodiagnosis by poliovirus-specific immunoglobulin M antibody tests using the capture enzyme-linked immunosorbent assay method were in good agreement with the results of virus isolation. The present study demonstrated that Pakistan is a region endemic for wild poliovirus and more aggressive preventive measures are needed to eradicate poliomyelitis from the region.
authors.affiliation: Department of Medical Zoology, Nagoya University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Isomura
authors.forename: A
authors.initials: A
authors.lastname: Mubina
authors.forename: A
authors.initials: A
authors.lastname: Dure-Samin
authors.forename: Y
authors.initials: Y
authors.lastname: Isihara
authors.forename: K
authors.initials: K
authors.lastname: Sakae
authors.forename: T
authors.initials: T
authors.lastname: Yamashita
authors.forename: O
authors.initials: O
authors.lastname: Nishio
authors.forename: A
authors.initials: A
authors.lastname: Ahmed
mesh_terms: D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007223:Infant; D010154:Pakistan / Q000453:epidemiology; D011051:Poliomyelitis / Q000453:epidemiology* / Q000821:virology; D017955:Poliovirus / Q000276:immunology / Q000302:isolation & purification; D011446:Prospective Studies; D012621:Seasons; D016036:Seroepidemiologic Studies
chemical_list: D007075:Immunoglobulin M