title: Metastatic malignant chondroblastoma.
abstract: A case of malignant chondroblastoma with metastases is reported. The patient initially presented with a lytic lesion in his left pubic ramus. He was treated with curettage, but the lesion recurred 3 years later. After repeated curettage, radiation therapy, and the late development of multiple bone and soft-tissue metastases, he succumbed to his disease 13 years after diagnosis. The surgical pathology from each of his several procedures was reviewed. Although no definite malignant transformation was apparent, a metastatic deposit curetted 3 months prior to death showed some increase in mitotic activity. Flow cytometry of specimens from the patient's first local recurrence and a late distant metastasis was performed and revealed the interval development of a minor aneuploid peak between the two samples. This fatal chondroblastoma is the only one in our series of 80 patients treated over the past 25 years.
authors.affiliation: Capital Region Orthopaedics and Sports Medicine, Jefferson City, Missouri, USA.
authors.forename: W B
authors.initials: WB
authors.lastname: Rodgers
authors.forename: H J
authors.initials: HJ
authors.lastname: Mankin
mesh_terms: D000328:Adult; D001706:Biopsy; D001859:Bone Neoplasms / Q000473:pathology* / Q000628:therapy; D002804:Chondroblastoma / Q000556:secondary*; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005434:Flow Cytometry; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000556:secondary*; D014057:Tomography, X-Ray Computed