Camptothecin resistance related to drug-induced down-regulation of topoisomerase I and to steps occurring after the formation of protein-linked DNA breaks.
Murren
J R
JR
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Beidler
D R
DR
Cheng
Y C
YC
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002166:Camptothecin / Q000494:pharmacology*; D018736:DNA Adducts; D004249:DNA Damage; D004264:DNA Topoisomerases, Type I / Q000378:metabolism*; D015536:Down-Regulation; D004351:Drug Resistance; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D059004:Topoisomerase I Inhibitors
D000972:Antineoplastic Agents, Phytogenic; D018736:DNA Adducts; D004791:Enzyme Inhibitors; D059004:Topoisomerase I Inhibitors; D004264:DNA Topoisomerases, Type I; D002166:Camptothecin