Biochemical changes during a cross-over treatment of doxazosin, moduretic and amlodipine in hypertensive patients.
A cross-over study was done to compare the effects of doxazosin, moduretic and amlodipine on biochemical values in 9 hypertensive Nigerians aged 35 to 65 years. Doxazosin therapy was characterized by significant increase in the levels of mean plasma total protein and albumin, while moduretic therapy showed significant reduction in the mean values of plasma creatinine and calcium. All other parameters did not show any significant variation during doxazosin and moduretic treatment phases; and amlodipine therapy did not have any effect on the biochemical values of the hypertensive patients.
Ahaneku
J E
JE
Department of Chemical Pathology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria.
Taylor
G O
GO
Walker
O
O
Agbedana
E O
EO
Sowunmi
A
A
Salako
L A
LA
D000328:Adult; D000368:Aged; D000584:Amiloride / Q000494:pharmacology / Q000627:therapeutic use; D017311:Amlodipine / Q000494:pharmacology / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001798:Blood Proteins / Q000032:analysis; D002118:Calcium / Q000097:blood; D003404:Creatinine / Q000097:blood; D018592:Cross-Over Studies; D004311:Double-Blind Method; D017292:Doxazosin / Q000494:pharmacology / Q000627:therapeutic use; D004338:Drug Combinations; D004573:Electrolytes / Q000097:blood; D006801:Humans; D006852:Hydrochlorothiazide / Q000494:pharmacology / Q000627:therapeutic use; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D008875:Middle Aged
D000959:Antihypertensive Agents; D001798:Blood Proteins; D004338:Drug Combinations; D004573:Electrolytes; D006852:Hydrochlorothiazide; D017311:Amlodipine; C010247:amiloride, hydrochlorothiazide drug combination; D000584:Amiloride; D003404:Creatinine; D017292:Doxazosin; D002118:Calcium