title: Two new aromatic constitutents from the rootwood of Aeschynomene mimosifolia.
abstract: The rootwood of Aeschynomene mimosifolia Vatke (Leguminosae) has yielded a new neoflavonoid, mimosifoliol (1), and an unusual C16-styrylcycloheptenone derivative, mimosifolenone (2). The structures of these compounds were determined on the basis of spectral analysis. Compound 1 demonstrated weak activity in DNA-strand scission assay, while compound 2 was found to be inactive. Mimosifoliol (1) was inactive toward several human cell lines, while 2 was moderately active against the KB cell line.
authors.affiliation: Chemistry and Life Sciences Group, Research Triangle Institute, North Carolina 27709, USA.
authors.forename: F
authors.initials: F
authors.lastname: Fullas
authors.forename: L J
authors.initials: LJ
authors.lastname: Kornberg
authors.forename: M C
authors.initials: MC
authors.lastname: Wani
authors.forename: M E
authors.initials: ME
authors.lastname: Wall
authors.forename: N R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: T E
authors.initials: TE
authors.lastname: Chagwedera
authors.forename: A D
authors.initials: AD
authors.lastname: Kinghorn
mesh_terms: D000179:Acrylates / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology*; D003508:Cycloheptanes / Q000302:isolation & purification* / Q000494:pharmacology; D004249:DNA Damage; D004354:Drug Screening Assays, Antitumor; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D013343:Styrenes / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D015030:Zimbabwe
chemical_list: D000179:Acrylates; D000972:Antineoplastic Agents, Phytogenic; D003508:Cycloheptanes; D010936:Plant Extracts; D013343:Styrenes; C102779:mimosifolenone; C102778:mimosifoliol; D006139:Guaiacol