Gallopamil reduces the post-transplantation acute tubular necrosis in kidneys from aged donors.
Due to a shortage of suitable kidneys for transplantation there has been an increase in the use of kidneys taken from old and marginal donors, which has led to a high incidence of acute tubular necrosis. Several reports suggest that the administration of calcium channel blockers improves the initial function after renal transplantation. We conducted a randomized, double-blind placebo-controlled trial to study the effect of the calcium channel blocker gallopamil on the incidence and course of acute tubular necrosis following cadaveric renal transplantation. A trend developed showing a decrease in episodes of acute tubular necrosis in gallopamil versus placebo, and became statistically significant when the outcome of kidneys from donors older than 50 years was analyzed separately [gallopamil 6/14 (42%) vs. placebo 10/11 (91%), P <0.01 corrected chi2]. We conclude that pre-transplantation renal graft perfusion and post-transplantation recipient treatment with gallopamil reduces the incidence of post-transplantation acute tubular necrosis, particularly in kidney taken from older donors.
Lustig
S
S
Department of Transplantation and Nephrology, Rabin Medical Center, Petah Tikva, Israel.
Shmueli
D
D
Boner
G
G
Bar-Nathan
N
N
Nakache
R
R
Yussim
A
A
Shahrabani
E
E
Shapira
Z
Z
D000328:Adult; D000368:Aged; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004311:Double-Blind Method; D005711:Gallopamil / Q000627:therapeutic use*; D006085:Graft Survival; D006801:Humans; D015994:Incidence; D016030:Kidney Transplantation / Q000009:adverse effects*; D007683:Kidney Tubular Necrosis, Acute / Q000188:drug therapy* / Q000209:etiology; D008875:Middle Aged; D016019:Survival Analysis; D014019:Tissue Donors; D016896:Treatment Outcome
D002121:Calcium Channel Blockers; D005711:Gallopamil