[The effect of nicotinamide on the enzymatic activity of the antioxidant defense in experimental diabetes].
Experiments on rats with experimental streptosotocin-induced diabetes have shown intensification of the lipid peroxidation processes and reduction of activity of antioxidant defensive enzymes. The content of G-SH and glutathione peroxidase activity has decreased in comparison with the normal rate by 69% and 28%, respectively. Glutathione reductase activity has risen by 20%. Activity of the antioxidant enzymes (superoxide dismutase, catalase) has reduced and the amount of the final product of lipid peroxidation, MDA has increased. Injection of nicotinamide to diabetic rats (200 mg/1 kg of weight) for 14 days normalized activity of the antioxidant enzyme system and the content of the lipid peroxidation products.
Velykyĭ
M M
MM
Burda
V A
VA
Biront
N V
NV
Oliiarnyk
O D
OD
Velykyĭ
A M
AM
D000818:Animals; D000975:Antioxidants; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000201:enzymology*; D004353:Drug Evaluation, Preclinical; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009536:Niacinamide / Q000627:therapeutic use*; D051381:Rats
D000975:Antioxidants; D009536:Niacinamide