Mapping of the genetically independent chicken major histocompatibility complexes B@ and RFP-Y@ to the same microchromosome by two-color fluorescent in situ hybridization.
The chicken MHC is organized in two genetically independent gene complexes B@ and RFP-Y@. Previous studies have shown the localization of the B@ complex on a small microchromosome. By using two-color fluorescent in situ hybridization, we demonstrate the localization of the RFP-Y@ complex to the same chromosome. A recombination hot spot between the two loci might account for their independent segregation.
Fillon
V
V
Laboratoire de Génétique Cellulaire, Centre INRA de Toulouse-Auzeville, Castanet Tolosan, France.
Zoorob
R
R
Yerle
M
M
Auffray
C
C
Vignal
A
A
D000818:Animals; D002645:Chickens / Q000235:genetics*; D002874:Chromosome Mapping; D003360:Cosmids; D017404:In Situ Hybridization, Fluorescence; D008285:Major Histocompatibility Complex / Q000235:genetics*; D005810:Multigene Family; D011995:Recombination, Genetic