[The function of the granulocytic system during immobilization stress with immunostimulation].
The experiments have been carried out on 36 rabbits. The animals of the 1st and 2nd groups were put to immobilization lying on their backs for 12 hours. The rabbits of the 2nd group were injected velozenum into peritoneum for 7 days before and after immobilization in order to stimulate immune system. 7-days injection of velozenum caused the evolution of neutrophil leucocytosis, raised the concentration of circulating immune sets. After immobilization neutrophilesis with degradation of neutrophils in both groups of animals that raised activation of acid phosphorus. Neutrophilesis and degradation in the 2nd group were less marked and protracted. The changes of indices, that characterize the state of immune system after immobilization, were purposeful in both 1st and 2nd groups identically, but those changes were less marked in the group of animals which immune systems had been stimulated. So, the stimulation of immune system reduces the activation lysosomal apparatus after immobilization. The regulation of homeostasis is possibly implemented in these conditions with the limited assistance of lysosomal ferments.
Sheĭko
V I
VI
Lunina
N V
NV
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D015550:Cell Degranulation / Q000187:drug effects; D005260:Female; D006098:Granulocytes / Q000187:drug effects / Q000502:physiology*; D007107:Immune System / Q000187:drug effects / Q000503:physiopathology; D007958:Leukocyte Count / Q000187:drug effects; D008247:Lysosomes / Q000187:drug effects / Q000502:physiology; D008297:Male; D011817:Rabbits; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000097:blood / Q000503:physiopathology*; D013949:Thymus Extracts / Q000494:pharmacology*; D013997:Time Factors
D000276:Adjuvants, Immunologic; D013949:Thymus Extracts; C059606:iilozen