Immunohaematological findings in healthy and HIV-1 infected adults in Dar es Salaam, Tanzania.
In order to assess the prognostic value of lymphocyte subsets and immune activation markers in HIV-1 infected Tanzanian patients, peripheral white blood cell(WBC) count, total lymphocytes, CD4+ and CD8+ T-lymphocytes and Beta-2 microglobulin (B-2M) concentrations were determined among healthy HIV-1 seronegative Tanzanian blood donors and in infected Tanzania individuals in different clinical stages of HIV-1 infection. CD4+ T-lymphocytes, CD8+ T-lymphocyte percentages, CD4:CD8 lymphocyte ratios and the concentrations of B-2M were strongly correlated with the clinical stages of HIV-1 infection. These results suggest that B-2M could be a useful prognostic marker in HIV-1 infection in settings where T-lymphocyte subset determinations cannot be done.
Urassa
W K
WK
Department of Microbiology and Immunology, Muhimbili University College, Dar es Salaam, Tanzania.
Lyamuya
E F
EF
Mbena
E
E
Kagoma
C
C
Bredberg Raden
U
U
Pallangyo
K P
KP
Magessa
P
P
Mhalu
F S
FS
Biberfeld
G
G
D000328:Adult; D016516:CD4-CD8 Ratio; D016022:Case-Control Studies; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000145:classification / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D016130:Immunophenotyping; D016131:Lymphocyte Subsets; D008297:Male; D011379:Prognosis; D015203:Reproducibility of Results; D013636:Tanzania; D014504:Urban Health; D001613:beta 2-Microglobulin / Q000276:immunology*
D001613:beta 2-Microglobulin