[Biochemical changes in cerebrospinal fluid associated with the neurotoxic action of HIV-1].
The aim of this study is to evaluate the usefulness of different markers to diagnose neurologic and psychiatric diseases due to HIV-1 infection Increased concentration of quinolenic acid has been implicated in the neurologic deficits and brain atrophy that may accompany infection with the HIV-1 virus. CFS concentrations of quinolenic acid have been implicated in the pathogenesis of the AIDS dementia complex. Cytokines liberation are very altered and this factor may be correlated with direct toxicity about central nervous system cells. Also are increased the values of neopterin. In the different stages of AIDS, the highest values are obtained in dementia complex. Neopterin, tryptofan and kinorenina, in blood and CFS are directly correlated with neurologic and psychiatry sintomatology. The highest values of soluble intercellular adhesion molecule 1 are found in HIV encephalopathy As well as are important the values, in CSF and blood of beta-2-M, Ag HIV, Ac41, tumor necrosis factor-alpha in the neurologic disease in HIV-1 infection
Gómez Alcalde
M S
MS
Departamento de Ciencias Sanitarias y Médico Sociales de la Facultad de Medicina de Alcalá de Henares.
Reyes Martín
A
A
D015526:AIDS Dementia Complex / Q000134:cerebrospinal fluid; D000163:Acquired Immunodeficiency Syndrome / Q000134:cerebrospinal fluid*; D015704:CD4 Antigens; D002448:Cell Adhesion; D016207:Cytokines / Q000502:physiology; D012321:DNA-Directed RNA Polymerases / Q000502:physiology; D015700:HIV Envelope Protein gp41; D015497:HIV-1; D006801:Humans; D017378:Quinolinic Acid / Q000134:cerebrospinal fluid*; D014364:Tryptophan / Q000134:cerebrospinal fluid; D001613:beta 2-Microglobulin / Q000502:physiology
D015704:CD4 Antigens; D016207:Cytokines; D015700:HIV Envelope Protein gp41; D001613:beta 2-Microglobulin; D014364:Tryptophan; D012321:DNA-Directed RNA Polymerases; D017378:Quinolinic Acid