The production of colibacillosis in turkeys following sequential exposure to Newcastle disease virus or Bordetella avium, avirulent hemorrhagic enteritis virus, and Escherichia coli.
Female large white turkeys were intranasally inoculated with either Newcastle disease virus (ND) or Bordetella avium (BA) at 4 weeks of age. This was followed by oral inoculation with an avirulent (vaccine) strain of hemorrhagic enteritis virus (HE) at 5 weeks and intravenous inoculation with Escherichia coli (EC) at 6 weeks. Control birds received ND, BA, or HE followed by EC; EC alone; or nothing at all. Turkeys receiving one agent prior to EC challenge did not experience a significant increase in mortality or pericarditis. Those exposed to ND or BA followed by HE and EC experienced a significant elevation in mortality and pericarditis. A highly significant positive correlation between the number of infectious agents encountered during primary exposure and the incidence of colibacillosis after EC challenge was demonstrated.
Pierson
F W
FW
Department of Large Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg 24061-0442, USA.
Larsen
C T
CT
Domermuth
C H
CH
D000281:Administration, Intranasal; D000284:Administration, Oral; D000818:Animals; D001884:Bordetella / Q000502:physiology*; D001885:Bordetella Infections / Q000175:diagnosis / Q000453:epidemiology / Q000662:veterinary; D004754:Enterobacter / Q000502:physiology*; D004756:Enterobacteriaceae Infections / Q000175:diagnosis / Q000453:epidemiology / Q000662:veterinary*; D004926:Escherichia coli / Q000502:physiology*; D004927:Escherichia coli Infections / Q000175:diagnosis / Q000453:epidemiology / Q000662:veterinary; D005260:Female; D015994:Incidence; D009521:Newcastle Disease / Q000175:diagnosis / Q000453:epidemiology; D009522:Newcastle disease virus / Q000502:physiology*; D010493:Pericarditis / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary; D011201:Poultry Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D011897:Random Allocation; D014422:Turkeys