title: [Synthesis and biological activity of hydrophosphoryl derivatives of amphotericin B].
abstract: Reactions of amphotericin B, a polyenic macrolide antibiotic, with aromatic aldehydes and H3PO2 resulted in formation of its new hydrophosphoryl derivatives. Physico-chemical and biological properties of the compounds were investigated. The biological studies showed that the hydrophosphoryl derivatives of amphotericin B were low toxic and had antifungal and antiviral activities.
authors.forename: V V
authors.initials: VV
authors.lastname: Belakhov
authors.forename: Iu D
authors.initials: IuD
authors.lastname: Shenin
authors.forename: R A
authors.initials: RA
authors.lastname: Arabiĭskiĭ
authors.forename: E B
authors.initials: EB
authors.lastname: Shtil'bans
mesh_terms: D000666:Amphotericin B / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010766:Phosphorylation; D013053:Spectrophotometry; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000998:Antiviral Agents; D000666:Amphotericin B