Effect of neuroleptics on ethanol-treated rats.
The subject of the present study is the effect of neuroleptic anaesthetics on sleeping time and some biochemical parameters of ethanol-treated and untreated rats. In one set of experiments involving four groups of animals, we studied how ethanol (12%, v/v) consumption for 10, 20 and 30 days influenced the sleeping time of animals after administration of a single dose of the investigated anaesthetics. In the other set of experiments, we studied the combined effect of 30 day ethanol consumption and each of the anaesthetics administered to the animals in multiple doses for 3 h, by determining the contents of cytochrome P450 and glutathione and the activities of glutathione peroxidase and lipid peroxidation. The results show that statistically significant changes of measured parameters are due to the action of ethanol and not of the neuroleptic anaesthetics.
Popović
M R
MR
Faculty of Sciences, Institute of Chemistry, Novi Sad, Yugoslavia.
Jakovljević
V S
VS
Gvozdenović
L V
LV
Lukić
V S
VS
D000758:Anesthesia; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D004329:Droperidol / Q000494:pharmacology; D004338:Drug Combinations; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D005283:Fentanyl / Q000494:pharmacology; D005978:Glutathione / Q000032:analysis; D005979:Glutathione Peroxidase / Q000032:analysis; D007649:Ketamine / Q000494:pharmacology; D008054:Lipid Peroxides / Q000032:analysis; D008099:Liver / Q000737:chemistry / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects*
D000777:Anesthetics; D014150:Antipsychotic Agents; D004338:Drug Combinations; D008054:Lipid Peroxides; D000431:Ethanol; D007649:Ketamine; C001451:Innovar; D003577:Cytochrome P-450 Enzyme System; D005979:Glutathione Peroxidase; D005978:Glutathione; D004329:Droperidol; D005283:Fentanyl