title: A scientific basis for the biologic regeneration of synovial joints.
abstract: Temporomandibular joint disorders represent a large group of conditions involving a local or more generalized musculoskeletal disease process. The disorders have many features and many causes and may result in limited or more severe damage of the joint associated tissues including the disks, the articular surface, the underlying bone, and the ligamentous structures. As our understanding of the molecular processes guiding skeletal tissue formation progresses, new opportunities arise in the field of skeletal tissue and joint repair. Reconstruction of the temporomandibular joint by means of scientifically designed approaches will revolutionize surgical treatment modalities.
authors.affiliation: Bone Research Branch, National Institute of Dental Research, Bethesda, Md, USA.
authors.forename: F P
authors.initials: FP
authors.lastname: Luyten
mesh_terms: D019485:Bone Morphogenetic Proteins; D001861:Bone Regeneration; D002356:Cartilage / Q000502:physiology; D055428:Growth Differentiation Factor 5; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D017746:Joint Capsule / Q000196:embryology / Q000502:physiology*; D009024:Morphogenesis; D012038:Regeneration; D013704:Temporomandibular Joint / Q000196:embryology / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology
chemical_list: D019485:Bone Morphogenetic Proteins; D055428:Growth Differentiation Factor 5; D006133:Growth Substances; D016212:Transforming Growth Factor beta; C090394:cartilage-derived-morphogenetic protein-2