title: The estimation of inspired desflurane concentration in a low-flow system.
abstract: We have examined the predictability of inspired desflurane concentration during low-flow anaesthesia using a to-and-fro breathing system. Twenty-two adult patients requiring mechanical ventilation of the lungs during surgery took part in the study. Using a fresh gas flow of 1 l.min-1, the ratio of inspired desflurane concentration to desflurane vaporizer setting was found to be approximately 0.75 after 9 min of anaesthesia and at 2 l.min-1 fresh gas flow the ratio was approximately 0.9 after 2 min of anaesthesia. These ratios were maintained throughout the procedure, except for a few minutes following each change in vaporizer setting.
authors.affiliation: Department of Anaesthesia, Hammersmith Hospital, London.
authors.forename: S
authors.initials: S
authors.lastname: Gowrie-Mohan
authors.forename: V
authors.initials: V
authors.lastname: Muralitharan
authors.forename: G G
authors.initials: GG
authors.lastname: Lockwood
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000764:Anesthesia, Closed-Circuit; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D000077335:Desflurane; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007530:Isoflurane / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide / Q000008:administration & dosage; D012121:Respiration, Artificial
chemical_list: D018685:Anesthetics, Inhalation; D000077335:Desflurane; D007530:Isoflurane; D009609:Nitrous Oxide