[Indicator of adrenoreceptors in cell membranes: reference values and informative validity in the assessment of the functional state of the cardiovascular system].
A new method of individual determination of sympathoadrenal activity (SAA) uses the parameter of beta-adrenoreception in cell membranes (beta-ARM) based on the erythrocyte model. Correlation of an individual reference beta-ARM value with specific features of hypertension states, and CVS responses to psychoemotional stress was studied. Described are the method, and normal distribution of individual beta-ARM values in healthy flyers, aviation students, non-flyers, and aviators with diagnosed the neurocirculatory dystonia of hypertensive type and patients with the hypertonic disease of 2nd stage (the overall numbers of subjects = 221). Another group of healthy subjects and patients with the hypertonic disease of 1st stage and different reference beta-ARM values (n = 39) participated in determination of HR and BP levels during the verbal count test. On the evidence of individual beta-ARM distribution in the test groups, the upper limit of the beta-ARM physiological norm (16.0 arbitrary units) was suggested to be a critical parameter in diagnosis of a hyperadrenergic state. Analysis of hemodynamics and the quality of verbal count during performance of a psychoemotional test by subjects with varying reference beta-ARM values revealed hyperreactive cardiovascular systems in and less successful fulfillment of the count test by subjects with high beta-ARM.
Dlusskaia
I G
IG
Striuk
R I
RI
Bobrovnitskiĭ
I P
IP
D000293:Adolescent; D000311:Adrenal Glands / Q000502:physiology; D000328:Adult; D000337:Aerospace Medicine; D002320:Cardiovascular Physiological Phenomena; D002462:Cell Membrane / Q000378:metabolism*; D004910:Erythrocyte Membrane / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009449:Neurocirculatory Asthenia / Q000175:diagnosis / Q000503:physiopathology; D011581:Psychological Tests; D011943:Receptors, Adrenergic, beta / Q000032:analysis; D012016:Reference Values; D013564:Sympathetic Nervous System / Q000502:physiology
D011943:Receptors, Adrenergic, beta