The modulatory effect of aminothiols on the clastogenic activity of X-rays assayed by the vivo mouse micronucleus test.
The modulatory effect of AET (S-2-aminoethylisothio-uronium bromide hydrobromide) and WR-2721 (S-2-/3-ami-nopropylamino/ethylphosphorothioic acid) on the clastogenic activity of X-rays was assessed by the in vivo mouse micronucleus test. The frequency of micronucleated polychromatic erythrocytes (MNPCEs) in the peripheral blood of adult male Swiss mice exposed to 5 Gy X-rays alone, or treated with AET or WR-2721, at a does of 200 mg/kg body weight, 15 or 30 minutes prior to X-irradiation, respectively, was determined during a fifteen-day period. The number of micronuclei increased on day 1 post-irradiation in X-irradiated mice and declined thereafter with the frequency of MNPCEs remaining lower in the thiol pre-treated mice. A more effective protection against the clastogenic activity of X-rays in the erythropoietic system was observed after WR-2721 administration than AET application.
Mazur
L
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Department of Animal Physiology, Jagiellonian University, Kraków, Poland.
D004999:Amifostine / Q000494:pharmacology*; D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D014965:X-Rays; D000338:beta-Aminoethyl Isothiourea / Q000494:pharmacology*
D016587:Antimutagenic Agents; D011837:Radiation-Protective Agents; D000338:beta-Aminoethyl Isothiourea; D004999:Amifostine