Inhibitory effect of arphamenine A on intestinal dipeptide transport.
Arphamenine A, an Arg-Phe analog without a peptide bond, has been reported to be a possible inhibitor of the peptide transporter [H. Daniel and S.A. Adibi, FASEB J., 8, 753 (1994)]. The present study demonstrated that arphamenine A is not a real inhibitor, but is a substrate for the transporter, being transported transepithelially under a proton gradient. The substrate specificity of the peptide transporter was wider than expected.
Enjoh
M
M
Department of Applied Biological Chemistry, Graduate School of Agriculture and Life Sciences, University of Tokyo, Japan.
Hashimoto
K
K
Arai
S
S
Shimizu
M
M
D001693:Biological Transport, Active / Q000187:drug effects; D018938:Caco-2 Cells; D002352:Carrier Proteins / Q000378:metabolism; D004151:Dipeptides / Q000378:metabolism*; D004594:Electrophysiology; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000187:drug effects; D018408:Patch-Clamp Techniques; D011480:Protease Inhibitors / Q000494:pharmacology*
D002352:Carrier Proteins; D004151:Dipeptides; D006146:Guanidines; D011480:Protease Inhibitors; C040038:arphamenine A