title: Virucidal activity of pure singlet oxygen generated by thermolysis of a water-soluble naphthalene endoperoxide.
abstract: Using the water-soluble naphthalene carrier of singlet oxygen NDPO2, we have shown that pure singlet oxygen is able to inactivate enveloped viruses (human immunodeficiency virus type 1, herpes simplex virus type 1, cytomegalovirus, vesicular stomatitis virus), but has no effect on non-enveloped viruses (adenovirus and poliovirus 1). These results are related to the experiments on photoinactivation of viruses by hydrophobic photosensitizers (merocyanine 540, hypericin, phthalocyanines, hematoporphyrin and benzoporphyrin derivatives) and they strengthen the hypothesis that singlet oxygen plays a predominant role in this process.
authors.affiliation: Laboratoire de Bactériologie-Virologie B. CHU de Lille, France.
authors.forename: A
authors.initials: A
authors.lastname: Dewilde
authors.forename: C
authors.initials: C
authors.lastname: Pellieux
authors.forename: S
authors.initials: S
authors.lastname: Hajjam
authors.forename: P
authors.initials: P
authors.lastname: Wattré
authors.forename: C
authors.initials: C
authors.lastname: Pierlot
authors.forename: D
authors.initials: D
authors.lastname: Hober
authors.forename: J M
authors.initials: JM
authors.lastname: Aubry
mesh_terms: D000260:Adenoviruses, Human / Q000187:drug effects; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D002522:Chlorocebus aethiops; D003587:Cytomegalovirus / Q000187:drug effects; D004267:DNA Viruses / Q000187:drug effects*; D015497:HIV-1 / Q000187:drug effects; D006367:HeLa Cells; D018259:Herpesvirus 1, Human / Q000187:drug effects; D006801:Humans; D009281:Naphthalenes / Q000494:pharmacology*; D009284:Naphthols / Q000494:pharmacology*; D010100:Oxygen; D017955:Poliovirus / Q000187:drug effects; D012328:RNA Viruses / Q000187:drug effects*; D014407:Tumor Cells, Cultured; D014709:Vero Cells; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects; D014867:Water
chemical_list: D000998:Antiviral Agents; D009281:Naphthalenes; D009284:Naphthols; D014867:Water; C058008:3,3'-(1,4-naphthylidene)diproprionate; D010100:Oxygen