Potential of neurotrophic factors in therapy of Parkinson's disease.
Neurotrophic factors of dopaminergic neurons may represent a potential neuroprotective therapy for PD. This article reviews published experiments that demonstrate the effects of neurotrophic factors on dopaminergic neurons in vitro and in vivo. At present this issue is predominantly investigated in basic neuroscientific research. Its possible future clinical relevance is discussed.
Möller
J C
JC
Department of Neurology, University of Munich, Federal Republic of Germany.
Sautter
J
J
Kupsch
A
A
D000313:Adrenal Medulla / Q000637:transplantation; D000818:Animals; D002478:Cells, Cultured; D004298:Dopamine / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D006133:Growth Substances / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008253:Macaca mulatta; D051379:Mice; D008818:Mice, Neurologic Mutants; D009410:Nerve Degeneration / Q000187:drug effects; D009414:Nerve Growth Factors / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology / Q000627:therapeutic use; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D009498:Neurotoxins / Q000633:toxicity; D016627:Oxidopamine / Q000633:toxicity; D010300:Parkinson Disease / Q000188:drug therapy* / Q000378:metabolism; D010302:Parkinson Disease, Secondary / Q000188:drug therapy / Q000601:surgery; D010525:Peripheral Nerves / Q000637:transplantation; D051381:Rats; D016042:Transplantation, Heterotopic
D006133:Growth Substances; D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; D009498:Neurotoxins; D016627:Oxidopamine; D004298:Dopamine