Renal cell carcinoma associated with cyclophosphamide therapy for Wegener's granulomatosis.
Cyclophosphamide therapy may be associated with the subsequent development of malignacies in many organs including the urinary tract. The main site in the urinary tract for development of these malignancies is the urinary bladder. Carcinoma of the kidney associated with cyclophosphamide therapy has previously been reported only in transplant recipients. The present case describes, for the first time, the development of renal cell carcinoma after treatment with cyclophosphamide in a patient with Wegener's granulomatosis.
Odeh
M
M
Department of Internal Medicine B, Bnai Zion Medical Center, Haifa, Israel.
D000368:Aged; D002273:Carcinogens / Q000009:adverse effects* / Q000627:therapeutic use; D002292:Carcinoma, Renal Cell / Q000139:chemically induced*; D003520:Cyclophosphamide / Q000009:adverse effects* / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D007680:Kidney Neoplasms / Q000139:chemically induced*; D008297:Male
D002273:Carcinogens; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide