title: Antiinflammatory activity of coumarins from Santolina oblongifolia.
abstract: Four coumarins were isolated from the EtOAc extract of the flower-tops of Santolina oblongifolia Boiss. (Compositae). They were identified as 7-methoxycoumarin (herniarin) (1), 6,7-dihydroxycoumarin (aesculetin) (2), 6-methoxy-7-glucosidylcoumarin (scopolin) (3), and 6-hydroxy-7-methoxycoumarin (scopoletin) (4). This is the first report of the isolation of aesculetin and scopolin from the genus Santolina. The isolated coumarins showed marked activity as inhibitors of eicosanoid-release from ionophore-stimulated mouse peritoneal macrophages.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University Complutense, Madrid, Spain.
authors.forename: A M
authors.initials: AM
authors.lastname: Silván
authors.forename: M J
authors.initials: MJ
authors.lastname: Abad
authors.forename: P
authors.initials: P
authors.lastname: Bermejo
authors.forename: M
authors.initials: M
authors.lastname: Sollhuber
authors.forename: A
authors.initials: A
authors.lastname: Villar
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000001:Calcimycin / Q000494:pharmacology; D002351:Carrageenan; D002855:Chromatography, Thin Layer; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology*; D015232:Dinoprostone / Q000378:metabolism; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control; D007476:Ionophores / Q000494:pharmacology; D015289:Leukotrienes / Q000378:metabolism; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013030:Spain; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000893:Anti-Inflammatory Agents; D003374:Coumarins; D007476:Ionophores; D015289:Leukotrienes; D010936:Plant Extracts; D000001:Calcimycin; D002351:Carrageenan; D015232:Dinoprostone