title: [Expert assessment of initial surgical management after experimental chemical eye burn].
abstract: BACKGROUND
  Initial surgical treatment of severe eye burns is important for the long lasting healing period. To look closer at the efficacy of the early surgical treatment and the possible consequences for woundhealing, the surgical interventions were examined in an animal experiment.
  
  
  METHODS
  The right eye of 20 rabbits each was burned with 1 n NaOH for 30 seconds followed by a surgical treatment 48 hours later. In the first study necrosectomy, tenonplasty, application of an artificial epithelium and blepharoplasty was withdrawn and the fornices were prevented from cicatrization by mechanical treatment treatment with blunt spatula. Antiinflammatory depotinjection of Volon A 40 was applicated additionally. After an interval of 4-18 weeks the eyes were examined histologically.
  
  
  RESULTS
  A higher risk for infections could be observed in eyes which underwent blepharorhaphy. Furthermore proliferative processes and corneal ulcerations were predominant. In contrast to these findings the latter complications could be prevented due to the clinical inspection of the artificial epithelium and described mechanical irritation of the fornices in the second study.
  
  
  CONCLUSIONS
  It could be shown that proliferative processes are major complications after severe burns of the eye. Nevertheless the intensity could be minimized by the consequent therapy. Furthermore it could be demonstrated that the artificial epithelium is an effective tool providing good prognosis for subsequently planned keratoplasty. To enable necessary postoperative inspection blepharoplasty should be avoided.
authors.affiliation: Laboratorium Augenklinik RWTH Aachen.
authors.forename: J
authors.initials: J
authors.lastname: Becker
authors.forename: S
authors.initials: S
authors.lastname: Salla
authors.forename: C
authors.initials: C
authors.lastname: Werry
authors.forename: K
authors.initials: K
authors.lastname: Oppermann
authors.forename: J
authors.initials: J
authors.lastname: Meyer
mesh_terms: D000818:Animals; D002057:Burns, Chemical / Q000473:pathology / Q000601:surgery*; D003315:Cornea / Q000473:pathology / Q000601:surgery; D065306:Corneal Injuries; D003692:Delayed-Action Preparations; D005126:Eye Burns / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D005143:Eyelids / Q000601:surgery; D007267:Injections; D011817:Rabbits; D017768:Skin, Artificial; D013530:Surgical Wound Infection / Q000473:pathology; D014221:Triamcinolone / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology*
chemical_list: D003692:Delayed-Action Preparations; D014221:Triamcinolone