title: [Increased urinary iron excretion rate in patients with non-insulin dependent diabetes mellitus].
abstract: Urinary iron excretion rate(u-FeER, microgram/min) in urine at night time from 58 patients with non-insulin dependent diabetes mellitus and 8 controls was measured by atomic absorption. The patients were divided into three groups according to urinary albumin excretion rate(u-AER), namely, Group I(n = 44): less than 20 micrograms/min of u-AER; Group II(n = 9): 20 < or = u-AER < 200 micrograms/min; Group III(n = 5): more than 200 micrograms/min of u-AER. The u-FeER in group III(56.3 +/- 14.8 ng/min, mean +/- SEM) was significantly higher than that in controls (4.0 +/- 1.6ng/min), group I(8.3 +/- 1.6 ng/min) and group II(18.5 +/- 6.5ng/min). The increase of u-FeER in group III indicates that urinary iron may at least partly play a role in development of diabetic nephropathy.
authors.affiliation: Second Department of Internal Medicine, Kochi Medical School, Nankoku.
authors.forename: K
authors.initials: K
authors.lastname: Nishiya
authors.forename: K
authors.initials: K
authors.lastname: Takamatsu
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Ikeda
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
mesh_terms: D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000652:urine*; D003928:Diabetic Nephropathies / Q000209:etiology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007501:Iron / Q000502:physiology / Q000652:urine*; D008297:Male; D008875:Middle Aged
chemical_list: D007501:Iron