title: Chimaeric VIP2/PACAP receptors reveal that agonist pharmacology but not signal transduction is determined by extracellular domain 1.
authors.affiliation: MRC Brain Metabolism Unit, University Department of Pharmacology, Edinburgh, Scotland. elutz@srv.1.bmu.mrc.ac.uk
authors.forename: E M
authors.initials: EM
authors.lastname: Lutz
authors.forename: C J
authors.initials: CJ
authors.lastname: MacKenzie
authors.forename: J
authors.initials: J
authors.lastname: Morrow
authors.forename: R
authors.initials: R
authors.lastname: Mitchell
authors.forename: J
authors.initials: J
authors.lastname: Bennie
authors.forename: S
authors.initials: S
authors.lastname: Carroll
authors.forename: E
authors.initials: E
authors.lastname: Clark
authors.forename: A J
authors.initials: AJ
authors.lastname: Harmar
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D019556:COS Cells; D002462:Cell Membrane / Q000502:physiology; D000242:Cyclic AMP / Q000378:metabolism; D017931:DNA Primers; D019204:GTP-Binding Proteins / Q000378:metabolism; D007295:Inositol Phosphates / Q000378:metabolism*; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000494:pharmacology*; D018377:Neurotransmitter Agents / Q000494:pharmacology; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D016133:Polymerase Chain Reaction; D051381:Rats; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; D011979:Receptors, Pituitary Hormone / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*; D018005:Receptors, Vasoactive Intestinal Peptide / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*; D051239:Receptors, Vasoactive Intestinal Peptide, Type II; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
chemical_list: C495403:Adcyap1 protein, rat; D017931:DNA Primers; D007295:Inositol Phosphates; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; D011979:Receptors, Pituitary Hormone; D018005:Receptors, Vasoactive Intestinal Peptide; D051239:Receptors, Vasoactive Intestinal Peptide, Type II; D011993:Recombinant Fusion Proteins; D014660:Vasoactive Intestinal Peptide; D000242:Cyclic AMP; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases