title: Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme.
abstract: The interleukin-1beta (IL-1beta) converting enzyme (ICE) processes the inactive IL-1beta precursor to the proinflammatory cytokine. ICE was also shown to cleave the precursor of interferon-gamma inducing factor (IGIF) at the authentic processing site with high efficiency, thereby activating IGIF and facilitating its export. Lipopolysaccharide-activated ICE-deficient (ICE-/-) Kupffer cells synthesized the IGIF precursor but failed to process it into the active form. Interferon-gamma and IGIF were diminished in the sera of ICE-/- mice exposed to Propionibacterium acnes and lipopolysaccharide. The lack of multiple proinflammatory cytokines in ICE-/- mice may account for their protection from septic shock.
authors.affiliation: Vertex Pharmaceuticals, Inc., 130 Waverly Street, Cambridge, MA 02139, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Gu
authors.forename: K
authors.initials: K
authors.lastname: Kuida
authors.forename: H
authors.initials: H
authors.lastname: Tsutsui
authors.forename: G
authors.initials: G
authors.lastname: Ku
authors.forename: K
authors.initials: K
authors.lastname: Hsiao
authors.forename: M A
authors.initials: MA
authors.lastname: Fleming
authors.forename: N
authors.initials: N
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Higashino
authors.forename: H
authors.initials: H
authors.lastname: Okamura
authors.forename: K
authors.initials: K
authors.lastname: Nakanishi
authors.forename: M
authors.initials: M
authors.lastname: Kurimoto
authors.forename: T
authors.initials: T
authors.lastname: Tanimoto
authors.forename: R A
authors.initials: RA
authors.lastname: Flavell
authors.forename: V
authors.initials: V
authors.lastname: Sato
authors.forename: M W
authors.initials: MW
authors.lastname: Harding
authors.forename: D J
authors.initials: DJ
authors.lastname: Livingston
authors.forename: M S
authors.initials: MS
authors.lastname: Su
mesh_terms: D000818:Animals; D019556:COS Cells; D020170:Caspase 1; D053148:Caspase 3; D020169:Caspases; D053471:Caspases, Initiator; D017077:Culture Media, Conditioned; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D016207:Cytokines / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis / Q000097:blood; D020382:Interleukin-18; D007728:Kupffer Cells / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D011498:Protein Precursors / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D011994:Recombinant Proteins / Q000378:metabolism / Q000494:pharmacology; D013154:Spleen / Q000166:cytology / Q000378:metabolism; D014162:Transfection
chemical_list: D017077:Culture Media, Conditioned; D016207:Cytokines; D020382:Interleukin-18; D008070:Lipopolysaccharides; D011498:Protein Precursors; D011994:Recombinant Proteins; D007371:Interferon-gamma; C505407:CASP3 protein, human; C093516:CASP4 protein, human; C505409:Casp3 protein, mouse; D053148:Caspase 3; D020169:Caspases; D053471:Caspases, Initiator; D003546:Cysteine Endopeptidases; D020170:Caspase 1