Role of cysteine residues in the N-terminal extracellular domain of the human VIP 1 receptor for ligand binding. A site-directed mutagenesis study.
Gaudin
P
P
Laboratoire de Neuroendocrinologie et Biologie Cellulaire Digestives, INSERM U 410, Faculté de Médecine Xavier Bichat, Paris, France. u410@bichat.inserm.fr
Couvineau
A
A
Maoret
J J
JJ
Rouyer-Fessard
C
C
Laburthe
M
M
D000595:Amino Acid Sequence; D000818:Animals; D019556:COS Cells; D000242:Cyclic AMP / Q000378:metabolism; D003545:Cysteine; D018076:DNA, Complementary; D006801:Humans; D007700:Kinetics; D008961:Models, Structural; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D017354:Point Mutation; D017433:Protein Structure, Secondary; D018005:Receptors, Vasoactive Intestinal Peptide / Q000737:chemistry* / Q000378:metabolism*; D051238:Receptors, Vasoactive Intestinal Polypeptide, Type I; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism; D014162:Transfection; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism* / Q000494:pharmacology
D018076:DNA, Complementary; D018005:Receptors, Vasoactive Intestinal Peptide; D051238:Receptors, Vasoactive Intestinal Polypeptide, Type I; D011994:Recombinant Proteins; D014660:Vasoactive Intestinal Peptide; D000242:Cyclic AMP; D003545:Cysteine