title: Comparison of technetium-99m-sestamibi scintimammography with contrast-enhanced MRI for diagnosis of breast lesions.
abstract: Scintimammography using 99mTc-sestamibi and contrast-enhanced MRI were performed to determine the diagnostic accuracy of either method in the diagnostic workup of patients suspicious for breast tumors.
  
  
  METHODS
  Fifty-six patients (42 with indeterminate mammograms) underwent preoperative prone planar scintimammography and pre- and postcontrast-enhanced MRI. Visually determined signal increase after application of Gd-DTPA was compared with visually scored sestamibi uptake, and the diagnoses of both methods were correlated with the final histopathologic results.
  
  
  RESULTS
  Overall, sensitivity and specificity of scintimammography for diagnosing breast cancer were 88% and 83%, respectively. In the subgroup of patients with indeterminate mammograms, sensitivity was 79% and specificity was 83%. MRI readings provided a higher sensitivity (91% with respect to all patients and 89% with respect to patients with indeterminate mammograms), but a considerably lower specificity (52% in both groups) due to contrast-enhancement in different benign lesions.
  
  
  CONCLUSIONS
  Due to its considerably higher specificity, scintimammography rather than MRI may be suitable to reduce the number of breast biopsies which yield benign results. Thus, this method may be suggested as the preferable tool in the diagnostic workup of patients with indeterminate mammographic findings.
authors.affiliation: Department of Nuclear Medicine, Klinikum Innenstadt, Ludwig-Maximilians-University, Munich, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Tiling
authors.forename: H
authors.initials: H
authors.lastname: Sommer
authors.forename: M
authors.initials: M
authors.lastname: Pechmann
authors.forename: R
authors.initials: R
authors.lastname: Moser
authors.forename: K
authors.initials: K
authors.lastname: Kress
authors.forename: T
authors.initials: T
authors.lastname: Pfluger
authors.forename: K
authors.initials: K
authors.lastname: Tatsch
authors.forename: K
authors.initials: K
authors.lastname: Hahn
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001940:Breast / Q000000981:diagnostic imaging*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003287:Contrast Media; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D011877:Radionuclide Imaging; D017256:Technetium Tc 99m Sestamibi / Q000627:therapeutic use*
chemical_list: D003287:Contrast Media; D017256:Technetium Tc 99m Sestamibi