Angina in McArdle's disease.
McArdle's disease (myophosphorylase deficiency) results in the inability to metabolise skeletal muscle glycogen to lactate. A patient with this condition developed angina and therefore offered a unique opportunity to explore the differential expression of the defective myophosphorylase gene in skeletal and cardiac muscle.
Nicholls
D P
DP
Royal Victoria Hospital, Belfast Northern Ireland.
Campbell
N P
NP
Stevenson
H P
HP
Patterson
V H
VH
D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000150:complications* / Q000201:enzymology; D002304:Cardiac Pacing, Artificial; D004591:Electrophoresis, Polyacrylamide Gel; D015870:Gene Expression; D006012:Glycogen Storage Disease Type V / Q000097:blood / Q000150:complications* / Q000201:enzymology; D006801:Humans; D007527:Isoenzymes; D019344:Lactic Acid / Q000097:blood; D008297:Male; D018482:Muscle, Skeletal / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology*; D006005:Phosphorylases / Q000032:analysis / Q000235:genetics*
D007527:Isoenzymes; D019344:Lactic Acid; D006005:Phosphorylases