Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function.
Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.
Mittrücker
H W
HW
Department of Immunology, University of Toronto, Toronto, Ontario, M5G 2C1, Canada.
Matsuyama
T
T
Grossman
A
A
Kündig
T M
TM
Potter
J
J
Shahinian
A
A
Wakeham
A
A
Patterson
B
B
Ohashi
P S
PS
Mak
T W
TW
D000818:Animals; D017951:Antigen Presentation; D001402:B-Lymphocytes / Q000276:immunology*; D001854:Bone Marrow Cells; D003602:Cytotoxicity, Immunologic; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D005260:Female; D018390:Gene Targeting; D006087:Graft vs Host Reaction; D007114:Immunization; D007136:Immunoglobulins / Q000097:blood; D050835:Interferon Regulatory Factors; D008206:Lymphatic Diseases / Q000209:etiology; D008213:Lymphocyte Activation; D016131:Lymphocyte Subsets / Q000166:cytology; D008221:Lymphoid Tissue / Q000166:cytology; D008297:Male; D012515:Mast-Cell Sarcoma / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D016513:Mice, SCID; D009368:Neoplasm Transplantation; D013601:T-Lymphocytes / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D000099218:Interferon Regulatory Factor-4
D004268:DNA-Binding Proteins; D007136:Immunoglobulins; D050835:Interferon Regulatory Factors; D014157:Transcription Factors; D000099218:Interferon Regulatory Factor-4