title: Steroids 54. Amino acylamidosteroids.
abstract: Aminosteroids were prepared and acylated with protected amino acids by means of the mixed anhydride or the active ester method. The tert-butyloxycarbonyl- (BOC) protecting group was eliminated by acidolysis, and the benzyloxycarbonyl- (Z) group by catalytic hydrogenation. 3 beta- and 6 beta-Glycylamidosteroids were prepared by indirect amination of chloroacetamido derivatives, formed by the Ritter reaction on the corresponding 3 alpha,5 alpha-cyclo and 5 alpha,6 alpha-epoxy steroids. Water-soluble double salts were produced from the compounds for pharmacological investigations.
authors.affiliation: Department of Organic Chemistry, Attila József University, Szeged, Hungary.
authors.forename: I
authors.initials: I
authors.lastname: Vincze
authors.forename: L
authors.initials: L
authors.lastname: Hackler
authors.forename: Z
authors.initials: Z
authors.lastname: Szendi
authors.forename: G
authors.initials: G
authors.lastname: Schneider
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000731:Androstanes / Q000737:chemistry; D011278:Pregnanes / Q000737:chemistry; D011281:Pregnatrienes / Q000737:chemistry; D012995:Solubility; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000596:Amino Acids; D000731:Androstanes; D011278:Pregnanes; D011281:Pregnatrienes; D013256:Steroids; C033936:androstane