Deciphering isozyme function: exploring cell biology with chemistry in the post-genomic era.
Genome sequencing projects are identifying protein sequences faster than it is possible to discover their functions. Fortunately, combinatorial chemistry offers an opportunity to develop new biological reagents with which to determine the roles of related isozymes.
Crews
C M
CM
Biology Department, Yale University, New Haven, CT 06520-8103, USA. craig.crews@yale.edu
D055598:Chemical Phenomena; D002621:Chemistry; D016678:Genome; D007527:Isoenzymes / Q000737:chemistry* / Q000235:genetics*; D048369:MAP Kinase Kinase 1; D020929:Mitogen-Activated Protein Kinase Kinases; D008958:Models, Molecular; D015335:Molecular Probes; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D017421:Sequence Analysis; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
D007527:Isoenzymes; D015335:Molecular Probes; D011505:Protein-Tyrosine Kinases; D017346:Protein Serine-Threonine Kinases; D048369:MAP Kinase Kinase 1; D020929:Mitogen-Activated Protein Kinase Kinases