Influence of apolipoprotein E polymorphism on the tracking of childhood levels of serum lipids and apolipoproteins over a 6-year period. The Bogalusa Heart Study.
The influence of apolipoprotein (apo) E polymorphism on the tracking of serum lipoprotein variables over a 6-year follow-up period was examined in 442 individuals aged 5-15 years at baseline. The apo E phenotype-specific differences in total cholesterol and low-density lipoprotein (LDL) cholesterol levels persisted in the study cohort at baseline and follow-up examinations. However, the correlations of baseline versus follow-up levels of total cholesterol and LDL cholesterol varied according to the apo E phenotype group, with the apo E2 group, carrying E2/2 and E3/2 phenotypes, showing highest correlation for these variables (r = 0.73 - 0.74) and the apo E4 carrying E3/4 and E4/4 phenotypes the lowest (r = 0.48 - 0.59). The tracking correlation for LDL cholesterol in the apo E2 group was different form that of the other phenotype groups (P < 0.05). In terms of persistence in ranks over time, of the individuals who were in the highest quartile of LDL cholesterol at baseline none of those in the apo E2 group, 63% of those in the apo E3 group carrying E3/3 phenotype, and 60% of those in the apo E4 group maintained this high rank at follow-up; corresponding values for persistence in ranking at the lowest quartile over time were 82% for the apo E2 group, 57% for the apo E3 group, and 33% for the apo E4 group. Further, in a multiple regression model, apo E phenotype was retained as a predictor variable only in the case of LDL cholesterol. Thus, apo E polymorphism influences not only the level of LDL cholesterol in childhood, but also its tracking at least over a 6-year period.
Srinivasan
S R
SR
Tulane Center for Cardiovascular Health, Tulane School of Public Health and Tropical Medicine, New Orleans, LA 70112-2824, USA.
Ehnholm
C
C
Wattigney
W A
WA
Berenson
G S
GS
D000293:Adolescent; D000328:Adult; D000483:Alleles; D001053:Apolipoproteins / Q000097:blood*; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D008078:Cholesterol, LDL / Q000097:blood; D015331:Cohort Studies; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D003430:Cross-Sectional Studies; D004587:Electrophoresis, Agar Gel; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015151:Immunoblotting; D008055:Lipids / Q000097:blood*; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D011237:Predictive Value of Tests; D011897:Random Allocation; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors
D001053:Apolipoproteins; D001057:Apolipoproteins E; D008078:Cholesterol, LDL; D008055:Lipids