title: Partial lipodystrophy associated with juvenile dermatomyositis: report of two cases.
abstract: A 27-year-old woman and a 13-year-old girl diagnosed with juvenile dermatomyositis in childhood developed clinical findings of partial lipodystrophy 10 years after diagnosis. Exhaustive clinical and laboratory examinations showed an association with other abnormalities: hypertrichosis, steatohepatitis, and an abnormal insulin response to the glucose loading test in the first patient. Hypertrichosis, steatohepatitis, insulin-resistant diabetes mellitus, and acanthosis nigricans were observed in the second patient. Renal function was normal in both patients. Although a localized form of lipodystrophy has been reported associated with connective tissue disease (connective tissue lipoatrophy), the partial form has been infrequently described in association with juvenile dermatomyositis.
authors.affiliation: Department of Dermatology, Hospital General Universitario, Valencia, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Quecedo
authors.forename: I
authors.initials: I
authors.lastname: Febrer
authors.forename: G
authors.initials: G
authors.lastname: Serrano
authors.forename: A
authors.initials: A
authors.lastname: Martinez-Aparicio
authors.forename: A
authors.initials: A
authors.lastname: Aliaga
mesh_terms: D000293:Adolescent; D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D002114:Calcinosis / Q000209:etiology; D016572:Cyclosporine / Q000627:therapeutic use; D003882:Dermatomyositis / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008060:Lipodystrophy / Q000209:etiology*; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D016572:Cyclosporine; D001379:Azathioprine; D011241:Prednisone