The distribution of noradrenaline, serotonin and gamma-aminobutyric acid in the monkey nucleus accumbens.
1. The recent histochemical studies have shown that the primate nucleus accumbens (NAC) can be subdivided into at least three subdivisions, the medial, ventral and dorsolateral subdivisions. 2. The medical subdivision possesses dense peptide- and dopamine-immunoreactive (IR) fibers. 3. In order to further investigate the neurochemical characteristics of the primate NAC, the distribution of structures that contain noradrenaline (NA), serotonin (5-HT) and gamma-aminobutyric acid (GABA) were examined in the macaque monkey by using transmitter-immunohistochemical methods. 4. Many NA-IR fibers were observed in the dorsal part of the NAC, corresponding to the medial subdivision. Fine varicose 5-HT-IR fibers were evenly distributed in the NAC. GABA-IR cell bodies and puncta were observed throughout the NAC as well as in the caudate nucleus and putamen. 5. The monkey rostral NAC displays a highly homogeneous distribution of all neuropeptides and neurotransmitters studied so far and we propose that this region be termed the rostral subdivision of the NAC.
Ikemoto
K
K
Département de Médecine Expérimentale, INSERM U52, CNRS ERS5645, Université Claude, Bernard, Lyon, France.
Kitahama
K
K
Maeda
T
T
Satoh
K
K
D000818:Animals; D005260:Female; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D008251:Macaca; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D009714:Nucleus Accumbens / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D009638:Norepinephrine