Pulmonary parenchymal abnormalities in congenital diaphragmatic hernia.
Congenital diaphragmatic hernia results in abnormal lung development. There is a global hypoplasia with both lungs affected, the ipsilateral lung more severely. This results in a reduction in the number of bronchial divisions and a decrease in the quantity and maturity of the alveoli. The pneumocytes are dysfunctional, resulting in a total quantitative and qualitative reduction in surfactant and a decrease in antioxidant enzyme activity.
Wilcox
D T
DT
Department of Paediatric Surgery, Great Ormond Street Children's Hospital, NHS Trust, London, United Kingdom.
Irish
M S
MS
Holm
B A
BA
Glick
P L
PL
D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D008168:Lung / Q000002:abnormalities*; D011663:Pulmonary Surfactants / Q000032:analysis; D017382:Reactive Oxygen Species
D011663:Pulmonary Surfactants; D017382:Reactive Oxygen Species