Chlorochimaphilin: a new antibiotic from Moneses uniflora.
A study of the antimicrobial compounds from Moneses uniflora resulted in the isolation of a novel compound, 8-chloro-2,7-dimethyl-1,4-naphthoquinone (8-chlorochimaphilin) (1), together with chimaphilin (2) and 3-hydroxychimaphilin (3) as the antimicrobial components. 2,7-Dimethyl-1,3-dihydroxynaphthyl 4-O-alpha-L-rhamnopyranoside (4) and 2,7-dimethoxy-1,4,8-trihydroxynaphthalene (6) were also isolated and identified.
Saxena
G
G
Department of Microbiology at West-East Center, University of British Columbia, Vancouver, Canada.
Farmer
S W
SW
Hancock
R E
RE
Towers
G H
GH
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000904:Antibiotics, Antitubercular / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009285:Naphthoquinones / Q000302:isolation & purification / Q000494:pharmacology; D010944:Plants / Q000737:chemistry*
C102614:8-chlorochimaphilin; D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular; D000935:Antifungal Agents; D000998:Antiviral Agents; D009285:Naphthoquinones