Age-related metabolic effects of acetaldehyde on rats with reference to detoxification enzymes and sulfhydryl groups.
Induced-acetaldehyde toxic effects on gluatathione [GSH] metabolism and sulfhydryl (SH) groups in liver and in brain of female albino rats with reference to age was studied. The total -SH groups were decreased whereas the specific activities of glutathione-S-transferase [GST] and glutathione peroxidase [GPo] were increased in acetaldehyde treated rats. However, the specific activity levels of glutathione reductase [GR] and gamma-glutamylcysteine synthetase [gamma-GCS] were decreased. In general, acetaldehyde induced changes in the specific activities of the enzymes that increase with increasing age.
Devi
G U
GU
Department of Zoology, S. V. University, Tirupati, India.
Indira
K
K
Babu
G R
GR
Chetty
C S
CS
D000079:Acetaldehyde / Q000633:toxicity*; D000375:Aging / Q000378:metabolism*; D000818:Animals; D005260:Female; D005721:Glutamate-Cysteine Ligase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D008658:Inactivation, Metabolic; D051381:Rats; D017208:Rats, Wistar; D013438:Sulfhydryl Compounds / Q000378:metabolism*
D013438:Sulfhydryl Compounds; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005721:Glutamate-Cysteine Ligase; D005978:Glutathione; D000079:Acetaldehyde