title: Contrast-enhanced magnetic resonance imaging for the detection of acute haemorrhagic necrotizing pancreatitis.
abstract: Eleven piglets with haemorrhagic necrotizing pancreatitis and nine piglets with oedematous pancreatitis were imaged using a multi-breath-hold TurboFLASH (TR 6.5 ms, TE 3 ms, TI 300 ms, flip angle 8 degrees , three slices) pre-excited T1-weighted sequence with an IV bolus injection of gadopentetate dimeglumine (Gd-DTPA, 0. 3 mmol/kg) as a contrast agent to show dynamic contrast enhancement of the pancreas by MRI. All piglets were imaged according to the same protocol before inducing the disease. Following the IV Gd-DTPA bolus, time-enhancement curve of the pancreas during haemorrhagic necrotizing pancreatitis was significantly lower than during oedematous pancreatitis. The enhancement curves for the healthy piglets and piglets with oedematous pancreatitis did not differ significantly. Each piglet served as its own control. Because the results of this initial study are similar to those obtained with contrast-enhanced CT, we conclude that our results may encourage further clinical trials, and contrast-enhanced dynamic MRI may be an alternative to the established method of CT for diagnosing acute haemorrhagic necrotizing pancreatitis.
authors.affiliation: Department of Radiology, Helsinki University Central Hospital, Haartmaninkatu 4, SF-00290 Helsinki, Finland.
authors.forename: A
authors.initials: A
authors.lastname: Piironen
authors.forename: R
authors.initials: R
authors.lastname: Kivisaari
authors.forename: P
authors.initials: P
authors.lastname: Pitkäranta
authors.forename: V P
authors.initials: VP
authors.lastname: Poutanen
authors.forename: P
authors.initials: P
authors.lastname: Laippala
authors.forename: P
authors.initials: P
authors.lastname: Laurila
authors.forename: L
authors.initials: L
authors.lastname: Kivisaari
mesh_terms: D000818:Animals; D003937:Diagnosis, Differential; D004487:Edema / Q000175:diagnosis; D019786:Gadolinium DTPA; D006470:Hemorrhage / Q000175:diagnosis*; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009942:Organometallic Compounds; D010182:Pancreatic Diseases / Q000175:diagnosis; D019283:Pancreatitis, Acute Necrotizing / Q000175:diagnosis*; D004369:Pentetic Acid / Q000031:analogs & derivatives*; D013552:Swine
chemical_list: D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA