Effects of childbearing on the natural history of panic disorder with comorbid mood disorder.
This historical prospective study included 22 women with panic disorder. They experienced 45 pregnancies associated with or after their first lifetime episode of panic disorder. Mood disorder predated or was associated with 32 of these pregnancies. The most common effect of pregnancy was No Change in symptoms from baseline during pregnancy and continued No Change postnatally for both panic attacks (n = 22; 49%) and depression (n = 19; 59%). The pattern of panic attack across gestations was consistent for only 5 of 14 multiparae. An interesting observation was that first lifetime onset of panic disorder was common postpartum (n = 4) or post-miscarriage (n = 2). First-onset depression was also common postpartum (n = 4).
Wisner
K L
KL
Case Western Reserve University School of Medicine, Women's Services, Mood Disorders Program, Cleveland, OH 44106, USA.
Peindl
K S
KS
Hanusa
B H
BH
D000328:Adult; D015897:Comorbidity; D019052:Depression, Postpartum / Q000175:diagnosis* / Q000523:psychology; D003866:Depressive Disorder / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016584:Panic Disorder / Q000175:diagnosis* / Q000523:psychology; D010555:Personality Inventory; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000523:psychology