title: Peritracheal fibrosis induced by sclerosing agents: a putative treatment for tracheomalacia.
abstract: Tracheomalacia is a congenital or acquired deficiency of the cartilages of the trachea. Treatment procedures include formation of external support by insertion of cartilage; bone for foreign material into the peritracheal tissue. A sclerosing agent, sodium morrhuate, was injected in the peritracheal tissue, blindly or after skin incision and subcutaneous tissue. In both groups peritracheal granulation tissue and inflammation evolved into peritracheal fibrosis surrounding the cartilage at the site of injection. The reaction was more pronounced following incision of the skin. No fibrosis was observed in a control group following hypertonic saline injection. The results suggest that injection of sclerosing agents might be considered as a conservative mode of treatment in tracheomalacia, by producing peritracheal fibrosis as external support.
authors.affiliation: Department of Pediatric Surgery, Hadassah Hospital, Kiryat Hadassah, Jerusalem, Israel.
authors.forename: K
authors.initials: K
authors.lastname: Abu-Dalu
authors.forename: P
authors.initials: P
authors.lastname: Faught
authors.forename: J L
authors.initials: JL
authors.lastname: Grosfeld
mesh_terms: D000818:Animals; D005355:Fibrosis; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012597:Sclerosing Solutions / Q000494:pharmacology*; D012976:Sodium Morrhuate / Q000494:pharmacology*; D014133:Tracheal Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology*; D014136:Tracheitis / Q000139:chemically induced
chemical_list: D012597:Sclerosing Solutions; D012976:Sodium Morrhuate