Leser-Trélat sign with anaplastic ependymoma--an autopsy case.
A 36-year-old Japanese male, who 7 years previously had been diagnosed as having an ependymoma in the left parietal region, had received surgery, chemotherapy and radiotherapy. He later developed a rapid growth of multiple skin lesions on his back and extremities, which coincided with a regrowth of the tumor. Postmortem examination revealed that the ependymoma showed anaplastic transformation and necrosis; however, no malignancy was observed in the extracranial organs. The skin lesions were histologically diagnosed as seborrheic keratoses. We have, therefore, diagnosed the patient as having Leser-Trélat sign associated with anaplastic ependymoma.
Hamada
Y
Y
Department of Neuropathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Iwaki
T
T
Muratani
H
H
Imayama
S
S
Fukui
M
M
Tateishi
J
J
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D001932:Brain Neoplasms / Q000473:pathology*; D004806:Ependymoma / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D017492:Keratosis, Seborrheic / Q000473:pathology*; D008297:Male
D014408:Biomarkers, Tumor