title: Three-part inventions: intracellular signaling and induced proximity.
abstract: Everyone has had the experience of stoking a fire; putting the logs close together causes flames to appear from previously dying embers. In a similar way, mere proximity might mediate qualitative biological responses. We discuss natural molecules that appear to have arisen to bring two proteins together and illustrate how this simple mechanism can be used to control a wide variety of biological processes.
authors.affiliation: Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, CA 94305-5428, USA. hf.grc@forsythe.stanford.edu
authors.forename: G R
authors.initials: GR
authors.lastname: Crabtree
authors.forename: S L
authors.initials: SL
authors.lastname: Schreiber
mesh_terms: D000591:Amino Acid Isomerases / Q000737:chemistry / Q000378:metabolism; D000941:Antigens / Q000378:metabolism; D005075:Biological Evolution; D002352:Carrier Proteins / Q000737:chemistry* / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D015195:Drug Design; D005805:Genes, MHC Class I; D006360:Heat-Shock Proteins / Q000737:chemistry / Q000378:metabolism; D008285:Major Histocompatibility Complex / Q000502:physiology*; D008954:Models, Biological; D008958:Models, Molecular; D019696:Peptidylprolyl Isomerase; D015398:Signal Transduction; D022021:Tacrolimus Binding Proteins
chemical_list: D000941:Antigens; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D006360:Heat-Shock Proteins; D000591:Amino Acid Isomerases; D022021:Tacrolimus Binding Proteins; D019696:Peptidylprolyl Isomerase