title: Chemotherapy-induced spontaneous pneumothorax in a patient with bulky mediastinal lymphoma: a rare oncologic emergency.
abstract: Chemotherapy-induced spontaneous pneumothorax (SP) has been described sporadically in chemosensitive tumors, particularly sarcoma, with multiple lung metastases. We present a patient who developed SP following rapid regression of bulky mediastinal lymphoma. Immediately on chest tube insertion, the lung recovered and further chemotherapy could be delivered uneventfully. We suggest that (1) chemotherapy-induced SP should be included amongst oncologic emergencies and that (2) a high degree of awareness of this complication is required.
authors.affiliation: Department of Oncology, Chemotherapy Unit, Rambam Medical Center and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
authors.forename: M E
authors.initials: ME
authors.lastname: Stein
authors.forename: Z
authors.initials: Z
authors.lastname: Shklar
authors.forename: K
authors.initials: K
authors.lastname: Drumea
authors.forename: L
authors.initials: L
authors.lastname: Goralnik
authors.forename: Y
authors.initials: Y
authors.lastname: Ben-Arieh
authors.forename: N
authors.initials: N
authors.lastname: Haim
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000009:adverse effects; D004317:Doxorubicin / Q000009:adverse effects; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000188:drug therapy* / Q000473:pathology; D008479:Mediastinal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011030:Pneumothorax / Q000139:chemically induced*; D011241:Prednisone / Q000009:adverse effects; D014750:Vincristine / Q000009:adverse effects
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone