The peroxisome proliferator-activated receptors: ligands and activators.
PPAR alpha and PPAR gamma represent related but distinct members of the nuclear receptor superfamily. PPAR alpha signaling is modulated by long-chain fatty acids, whereas PPAR gamma ligands are potent antidiabetic agents.
Forman
B M
BM
Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, California 92037, USA.
Chen
J
J
Evans
R M
RM
D000818:Animals; D005227:Fatty Acids / Q000737:chemistry / Q000494:pharmacology; D015971:Gene Expression Regulation, Enzymologic; D008024:Ligands; D051379:Mice; D008830:Microbodies / Q000187:drug effects*; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D000077154:Rosiglitazone; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000494:pharmacology; D045162:Thiazolidinediones; D014157:Transcription Factors / Q000502:physiology*
D005227:Fatty Acids; D008024:Ligands; D018160:Receptors, Cytoplasmic and Nuclear; D013844:Thiazoles; D045162:Thiazolidinediones; D014157:Transcription Factors; D000077154:Rosiglitazone