title: Differences in the influence of AIN-purified and non-purified diets on the development of hypertension in SHR and DOCA-salt hypertensive rats.
abstract: The influence of non-purified and AIN purified diets on the development of hypertension was examined in deoxycorticosterone acetate (DOCA)-salt hypertensive rats and SHRs. For DOCA-salt hypertensive rats, the development of hypertension was slower in rats fed the AIN 76-purified diet than in those fed the non-purified diet throughout the experimental period of about five weeks. In an experiment using spontaneously hypertensive rats (SHRs), 4-week-old rats were fed either a non-purified diet, a AIN76-purified diet or a AIN93G-purified diet for about nine weeks. In the first 1-2 weeks, the blood pressure was lower in the SHRs fed the AIN93G-purified diet than in those fed the non-purified diet. However, no significant difference in blood pressure was observed within the SHR group thereafter.
authors.affiliation: National Institute of Health and Nutrition, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Uramoto
authors.forename: K
authors.initials: K
authors.lastname: Umegaki
authors.forename: Y
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: T
authors.initials: T
authors.lastname: Yamane
authors.forename: T
authors.initials: T
authors.lastname: Esashi
mesh_terms: D000821:Animal Feed; D000818:Animals; D001794:Blood Pressure; D003900:Desoxycorticosterone; D004032:Diet; D006973:Hypertension / Q000209:etiology*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D017207:Rats, Sprague-Dawley; D012965:Sodium Chloride / Q000008:administration & dosage
chemical_list: D003900:Desoxycorticosterone; D012965:Sodium Chloride