Acute psychosis associated with abrupt withdrawal of carbamazepine following intoxication.
Carbamazepine is regularly used in the treatment of trigeminal neuralgia. Although exacerbation of psychosis has been described following abrupt discontinuation of carbamazepine in chronic schizophrenics, a withdrawal syndrome has not been reported previously in patients treated for trigeminal neuralgia. The case presented here suggests that abrupt withdrawal of toxic concentrations of carbamazepine may precipitate a withdrawal reaction, which is manifest some days after discontinuation of the drug. Therefore it may be advisable to withdraw therapy slowly in these situations.
Darbar
D
D
Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland.
Connachie
A M
AM
Jones
A M
AM
Newton
R W
RW
D000208:Acute Disease; D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects* / Q000627:therapeutic use; D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D011605:Psychoses, Substance-Induced / Q000175:diagnosis*; D013375:Substance Withdrawal Syndrome
D018712:Analgesics, Non-Narcotic; D002220:Carbamazepine