Cytomegalovirus gB genotype distribution differs in human immunodeficiency virus-infected patients and immunocompromised allograft recipients.
Cytomegalovirus isolates can be grouped into 4 gB and 2 gH genotypes. gB genotypes were studied in patients infected with human immunodeficiency virus (HIV) and in allograft transplantation recipients. In allograft recipients, the distribution of gB 1, -2, -3, and -4 in leukocytes and urine, respectively, was 36%, 21%, 43%, and 0% and 39%, 30%, 17%, and 13%. However, in leukocytes of HIV-infected patients with <100/microL CD4 cells, gB1 was found significantly less often than in allograft recipients (11% vs. 36%) but gB2 was more frequent (56% vs. 21%; P < .05). The decreased incidence of gBl and increased incidence of gB2 compared with allograft recipients was also seen in urine of HIV-infected patients and reflected the distribution seen in leukocytes. gB4 was found significantly more often (P < .05) in semen than in leukocytes of HIV-infected patients with < 100/microL CD4 cells. gB1-4 genotypes were similar in patients with < 100/microL CD4 cells with or without retinitis.
Rasmussen
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L
Center for AIDS Research, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, CA 94305, USA. lucy.rasmussen@stanford.edu
Hong
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C
Zipeto
D
D
Morris
S
S
Sherman
D
D
Chou
S
S
Miner
R
R
Drew
W L
WL
Wolitz
R
R
Dowling
A
A
Warford
A
A
Merigan
T C
TC
D017088:AIDS-Related Opportunistic Infections / Q000821:virology*; D000595:Amino Acid Sequence; D001483:Base Sequence; D003587:Cytomegalovirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000821:virology*; D017726:Cytomegalovirus Retinitis / Q000821:virology; D005838:Genotype; D006801:Humans; D016867:Immunocompromised Host; D007962:Leukocytes / Q000821:virology; D008297:Male; D008969:Molecular Sequence Data; D009894:Opportunistic Infections / Q000821:virology*; D010614:Pharynx / Q000821:virology; D012661:Semen / Q000821:virology; D014181:Transplantation Immunology; D014184:Transplantation, Homologous; D014556:Urine / Q000821:virology