Reversal of encephalopathy during treatment with amphotericin-B.
A case of reversible encephalopathy during treatment with Amphotericin-B (AMB) is described. The comparison of the clinical course of AMB encephalopathy with total dose of AMB, cranial radiotherapy and MRI data available in previously reported cases, shows that this complication is characterized by a progressive, dose-dependent course, possibly influenced by cranial irradiation.
Antonini
G
G
Department of Neuroscience, University of Rome LA Sapienza, Italy.
Morino
S
S
Fiorelli
M
M
Fazi
P
P
Ceschin
V
V
Petti
C
C
D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D000935:Antifungal Agents; D000666:Amphotericin B