Antiplatelet activity of cis-resveratrol.
The anti-aggregating effect of cis-resveratrol (cis-3,4,5- trihydroxystilbene) has been evaluated in vitro in different concentrations on platelet-rich plasma from health volunteers. Cis-resveratrol at the concentration of 1 x 10(-5) and 1 x 10(-6) M was able to decrease collagen-induced platelet aggregation by 43.5 +/-11.4% and 26.8 +/- 14.6%, while trans-resveratrol at the same concentration showed a slightly lower activity. In view of the behaviour of these two isomers in biological fluids, the evaluation of resveratrol activity in animals and humans take into account the total amount of the two isomers.
Bertelli
A A
AA
Institute of Anatomy, University of Milan, Italy.
Giovannini
L
L
Bernini
W
W
Migliori
M
M
Fregoni
M
M
Bavaresco
L
L
Bertelli
A
A
D003094:Collagen / Q000037:antagonists & inhibitors* / Q000187:drug effects; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000097:blood / Q000494:pharmacology*; D000077185:Resveratrol; D013237:Stereoisomerism; D013267:Stilbenes / Q000097:blood / Q000494:pharmacology*
D010975:Platelet Aggregation Inhibitors; D013267:Stilbenes; D003094:Collagen; D000077185:Resveratrol