Assessing coronary artery disease with dipyridamole technetium-99m-tetrofosmin SPECT: a multicenter trial.
Exercise 99mTc-tetrofosmin myocardial scintigraphy is as accurate as exercise 201TI imaging. Thus far, no data are available on tetrofosmin imaging during pharmacologic stress. We evaluated the feasibility of using. 99mTc-tetrofosmin myocardial SPECT during vasodilation with dipyridamole for detecting coronary artery disease.


METHODS
Sixty-four patients, enrolled in three centers in the U.S., underwent one-day dipyridamole/rest tetrofosmin SPECT. Coronary angiography, performed in 59 patients within 2 mo of the SPECT study, revealed normal coronary arteries or insignificant coronary stenosis in 11 patients and significant (> or = 50% luminal diameter stenosis) coronary stenoses in 48 patients.


RESULTS
Sensitivity and specificity of tetrofosmin SPECT for detecting coronary artery disease were 85% and 55%, respectively, in the overall population and 81% and 55% in patients without prior coronary artery bypass surgery. The overall sensitivity and specificity of tetrofosmin tomographic imaging for detection of individual coronary stenoses were 53% and 72%, respectively, in the overall population and 54% and 80% in the patients without prior coronary artery bypass surgery.


CONCLUSIONS
One-day dipyridamole/rest 99mTc-tetrofosmin myocardial perfusion imaging is feasible and has a high sensitivity for detection of coronary artery disease.
He
Z X
ZX
Section of Cardiology, Baylor College of Medicine, Houston, Texas, USA.
Iskandrian
A S
AS
Gupta
N C
NC
Verani
M S
MS
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D004176:Dipyridamole; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon; D014665:Vasodilator Agents
D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D014665:Vasodilator Agents; C078700:technetium tc-99m tetrofosmin; D004176:Dipyridamole