Exclusion of one pedigree affected by adult onset primary open angle glaucoma from linkage to the juvenile glaucoma locus on chromosome 1q21-q31.
A locus for autosomal dominant juvenile onset primary open angle glaucoma (POAG) was recently assigned to chromosome region 1q21-q31. In the present study, a large Greek family with autosomal dominant adult onset POAG was investigated using microsatellite markers. Exclusion of linkage of the adult onset POAG gene to the region D1S194-D1S191 was obtained in this pedigree. Therefore, the data provide evidence that juvenile and adult onset POAG are genetically distinct disease entities.
Avramopoulos
D
D
Department of Genetics, Institute of Child Health, Athens, Greece.
Kitsos
G
G
Economou-Petersen
E
E
Grigoriadou
M
M
Vassilopoulos
D
D
Papageorgiou
C
C
Psilas
K
K
Petersen
M B
MB
D000328:Adult; D017668:Age of Onset; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant / Q000235:genetics; D008040:Genetic Linkage; D005902:Glaucoma, Open-Angle / Q000235:genetics*; D006115:Greece; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D010375:Pedigree