title: Increases in rates of resistance to trimethoprim.
abstract: Trimethoprim alone or in combination with a sulfonamide is an effective and relatively inexpensive antibacterial medication. However, a dramatic increase in the rate of resistance to trimethoprim along with high-level resistance to sulfonamides has been seen during the past two decades. The mechanisms of resistance show a remarkable evolutionary adaptation.
authors.affiliation: Antimicrobial Research Laboratory, National Public Health Institute, Turku, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Huovinen
mesh_terms: D000892:Anti-Infective Agents, Urinary / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects / Q000201:enzymology / Q000235:genetics; D004363:Drug Utilization; D011815:R Factors; D013449:Sulfonamides / Q000627:therapeutic use*; D014295:Trimethoprim / Q000627:therapeutic use*; D014296:Trimethoprim Resistance / Q000235:genetics; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use*
chemical_list: D000892:Anti-Infective Agents, Urinary; D013449:Sulfonamides; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim