title: Methotrexate-associated appearance and rapid progression of rheumatoid nodules in systemic-onset juvenile rheumatoid arthritis.
abstract: Rheumatoid nodules are a rare extraarticular manifestation of juvenile rheumatoid arthritis (JRA), usually detected in patients with polyarticular-onset disease and positive rheumatoid factor (RF). To date, there has not been a published report of rheumatoid nodules in systemic-onset JRA. Low-dose methotrexate (MTX) is generally considered to be the most useful second-line drug in the treatment of polyarticular JRA. In adult RA, MTX has been shown to be associated with appearance and progression of rheumatoid nodules. This report describes a 3-year-old girl with RF-negative, antinuclear antibody-negative systemic JRA who developed multiple rheumatoid nodules on the scalp and trunk during MTX therapy. The first nodule developed on the scalp 6 months after MTX treatment was initiated. Previous treatment with azathioprine was not associated with nodulosis. This represents an atypical case of MTX-associated accelerated nodulosis in systemic JRA, and raises the problem of treatment plan modification in the presence of this side effect.
authors.affiliation: University of Florence, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Falcini
authors.forename: G
authors.initials: G
authors.lastname: Taccetti
authors.forename: M
authors.initials: M
authors.lastname: Ermini
authors.forename: S
authors.initials: S
authors.lastname: Trapani
authors.forename: A
authors.initials: A
authors.lastname: Calzolari
authors.forename: A
authors.initials: A
authors.lastname: Franchi
authors.forename: M M
authors.initials: MM
authors.lastname: Cerinic
mesh_terms: D018501:Antirheumatic Agents / Q000009:adverse effects*; D001171:Arthritis, Juvenile / Q000188:drug therapy*; D002675:Child, Preschool; D002985:Clinical Protocols; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects*; D009336:Necrosis; D012218:Rheumatoid Nodule / Q000139:chemically induced* / Q000473:pathology
chemical_list: D018501:Antirheumatic Agents; D008727:Methotrexate