title: Down syndrome and coeliac disease: usefulness of antigliadin and antiendomysium antibodies.
abstract: The usefulness of antigliadin (AGA) and antiendomysium antibodies (EMA) as a screening test for coeliac disease (CD) in 113 Down syndrome (DS) patients (61 children) was evaluated. AGA IgA were present in 22.1%, AGA IgG in 48.6%, EMA in 6.2%. Four symptomatic patients, AGA- and EMA-positive, were affected by CD (3.5%). In three AGA-positive and EMA-positive subjects, permission for intestinal biopsy was refused, while in two AGA-positive and EMA-negative children, the intestinal mucosa was normal. Our study confirms the association of CD and DS, and suggests the usefulness of EMA determination as a test for selecting DS patients for intestinal biopsy.
authors.affiliation: I Clinica Pediatrica Università La Sapienza, Roma, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Bonamico
authors.forename: A
authors.initials: A
authors.lastname: Rasore-Quartino
authors.forename: P
authors.initials: P
authors.lastname: Mariani
authors.forename: P
authors.initials: P
authors.lastname: Scartezzini
authors.forename: P
authors.initials: P
authors.lastname: Cerruti
authors.forename: M C
authors.initials: MC
authors.lastname: Tozzi
authors.forename: M
authors.initials: M
authors.lastname: Cingolani
authors.forename: G
authors.initials: G
authors.lastname: Gemme
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D002446:Celiac Disease / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D005903:Gliadin / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D005903:Gliadin