title: Soft tissue infections and the diabetic foot.
abstract: Soft tissue infections are classified as local or spreading. Spreading soft tissue infections are potentially life-threatening conditions, requiring prompt diagnosis and treatment. The information presented is based on a literature review and the authors' clinical experience. Diagnosis of soft tissue infections is aimed at determining the level of infection (skin, fascia, muscle) and whether necrosis is present. The bacteriology of these infections is varied and is of secondary importance. Treatment of skin infections that have no dead tissue is with antibiotics alone. Infections at the fascial or muscle level and those with necrosis at any level require surgical debridement and adjuvant antibiotics. The feet of diabetic patients are prone to plantar forefoot ulcers associated with tissue destruction and infection. The vast majority are caused by mechanical factors. If local immune defenses are adequate, bacterial colonization occurs without infection. Most diabetic foot ulcers will respond to relief of pressure, which may require total contact casting. Antibiotics and debridement are required in infected or deep ulcers, or when the ulcer does not respond to total contact casting.
authors.affiliation: Department of Surgery, University of Toronto, Ontario, Canada.
authors.forename: A J
authors.initials: AJ
authors.lastname: Smith
authors.forename: T
authors.initials: T
authors.lastname: Daniels
authors.forename: J M
authors.initials: JM
authors.lastname: Bohnen
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D017719:Diabetic Foot / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery*; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D006801:Humans; D018461:Soft Tissue Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery*
chemical_list: D000900:Anti-Bacterial Agents