QSAR studies of some sulphonamidobenzophenone oximes with antiviral activity.
A study of quantitative structure-activity relationships (QSAR) has been performed for some sulphonamidobenzophenone oximes to investigate the mechanism of their antiviral activity against polio and rhino viruses. It has been shown that viral macromolecule synthesis could be the target of their action and that the antiviral activity of the compounds is predominantly controlled by steric factors.
Hadjipavlou-Litina
D J
DJ
Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Greece.
D000998:Antiviral Agents / Q000494:pharmacology*; D010091:Oximes / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D010091:Oximes