Mechanisms of interference with the MHC class I-restricted pathway of antigen presentation by herpesviruses.
Herpesviruses are an ancient, ubiquitous family of DNA viruses, most of which share a lifestyle of latently or persistently infecting a young host, and spreading to infect a new host a generation later. Most herpesviruses interfere with antigen presentation via the MHC class I-restricted pathway of antigen presentation, suggesting that impairment of the cytotoxic T lymphocyte response is necessary for the maintenance of this lifestyle. The diverse molecular mechanisms that have so far been discovered employed by Epstein-Barr virus, herpes simplex viruses, and human and murine cytomegaloviruses are described in this review.
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Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland 97201, USA.
D000818:Animals; D017951:Antigen Presentation; D006564:Herpesviridae / Q000276:immunology* / Q000472:pathogenicity*; D006566:Herpesviridae Infections / Q000276:immunology* / Q000821:virology*; D015395:Histocompatibility Antigens Class I / Q000502:physiology*; D006801:Humans
D015395:Histocompatibility Antigens Class I