[Hyperprolactinemia and autoimmunity].
Prolactin is a pituitary hormone with several functions, one of them, immunoregulatory. Patients with prolactinoma develop hyperprolactinemia. In the next two cases, patients with microprolactinoma, both autoimmune disease associated. First patient, male, with multiple sclerosis; the other one patient, female, with systemic lupus erythematosus. Treatment of hyperprolactinemia with bromocriptine was associated with satisfactory clinical evolution, and a reduction of dosage of immunosuppressor treatment. The patients with multiple sclerosis had neurological functions recovery and the patients with systemic lupus erythematosus had severe relapse of disease each time she dropped bromocriptine treatment. Pituitary function must be evaluated in autoimmune disease, to search alterations like hyperprolactinemia who influenced immune function.
Compañ González
D A
DA
Servicio de inmunología clínica y alergia, Centro Médico Nacional 20 de Noviembre, ISSSTE, México.
Martínez Aguilar
N E
NE
Vargas Camaño
M E
ME
Guido Bayardo
R
R
D000328:Adult; D001327:Autoimmune Diseases / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D001971:Bromocriptine / Q000627:therapeutic use; D018492:Dopamine Antagonists / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D008297:Male
D018492:Dopamine Antagonists; D001971:Bromocriptine