Molecular biology of human oral cancer.
The application of molecular biological tools to the study of cancer has significantly advanced the field of human cancer research. Such study has demonstrated the involvement of two classes of highly conserved cellular genes in the malignant transformation process: oncogenes and tumor suppressor genes. Despite these advances in the molecular biology of human cancers, our understanding of human oral cancer lags behind that of cancer of other body sites. This review attempts to assess the current status of the molecular biology of human oral cancer.
Wong
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Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA.
Todd
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Tsuji
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Donoff
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D015815:Cell Adhesion Molecules / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D016147:Genes, Tumor Suppressor / Q000235:genetics; D016158:Genes, p53 / Q000235:genetics; D006133:Growth Substances / Q000235:genetics; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics; D008967:Molecular Biology; D009062:Mouth Neoplasms / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics; D009857:Oncogenes / Q000235:genetics; D011506:Proteins / Q000235:genetics; D011956:Receptors, Cell Surface / Q000235:genetics; D015290:Second Messenger Systems / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D019699:Thrombospondins; D014157:Transcription Factors / Q000235:genetics; D025521:Tumor Suppressor Proteins
C096151:CDK2AP1 protein, human; D015815:Cell Adhesion Molecules; D006133:Growth Substances; D008562:Membrane Glycoproteins; D011506:Proteins; D011956:Receptors, Cell Surface; D019699:Thrombospondins; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins