The diagnostic value of Tc-99m human polyclonal immunoglobulin imaging compared to Tc-99m HMPAO labeled leukocytes in inflammatory bowel disease.
The aim of this study was to establish the usefulness of Tc-99m human polyclonal immunoglobulin (HIG) imaging in a group of patients who were suspected of having inflammatory bowel disease (IBD). The authors performed 30 scans (15 with Tc-99m HMPAO leukocytes and 15 with Tc-99m HIG) on 15 patients with IBD. Ten patients had Crohn's disease and five had ulcerative colitis. The sensitivity of Tc-99m HIG scintigraphy for detecting IBD was 33%, while the sensitivity of Tc-99m HMPAO leukocyte imaging was 100%. The Tc-99m HMPAO leukocyte imaging also detected a larger number of affected segments and provided better image quality of the extent of disease than Tc-99m HIG. On the basis of these results, the authors believe that Tc-99m HIG imaging is not a useful technique in the evaluation of patients with IBD, in the identification of location, or the extension or degree of disease activity.
Delgado Castro
M
M
Nuclear Medicine Department of the University Teaching Hospital, Zaragoza, Spain.
Lancha
C
C
Prats
E
E
Mitjavilla
M
M
Abós
D
D
Martín-Curto
L M
LM
Crespo
A
A
Banzo
J
J
D003093:Colitis, Ulcerative / Q000000981:diagnostic imaging*; D003424:Crohn Disease / Q000000981:diagnostic imaging*; D006801:Humans; D007136:Immunoglobulins; D007962:Leukocytes; D015609:Organotechnetium Compounds; D010091:Oximes; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D013667:Technetium; D019690:Technetium Tc 99m Exametazime; D013997:Time Factors
D007136:Immunoglobulins; D015609:Organotechnetium Compounds; D010091:Oximes; C065376:technetium Tc 99m immunoglobulin; D019690:Technetium Tc 99m Exametazime; D013667:Technetium