Effects of felbamate on veratridine- and K(+)-stimulated release of glutamate from mouse cortex.
Felbamate is a novel anticonvulsant which may modulate the strychnine-insensitive glycine site of the N-methyl-D-aspartate (NMDA) receptor complex. This study examined the effect of felbamate and 5,7-dichlorokynurenic acid on veratridine (20 microM)- and K+ (60 mM)-stimulated release of amino acids in mouse cortical slices. Felbamate significantly decreased veratridine-induced release of glutamate at 400 microM and 800 microM but had no effect on K(+)-stimulated release. 5,7-Dichlorokynurenic acid had no effect on amino-acid release in concentrations up to 200 microM. The inhibitory effect of felbamate on veratridine-induced release of glutamate may be due to inactivation of voltage-sensitive Na+ channels.
Srinivasan
J
J
Department of Pharmacology and Therapeutics, University of Wales College of Medicine, Heath Park, Cardiff, UK.
Richens
A
A
Davies
J A
JA
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D000078328:Felbamate; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018696:Neuroprotective Agents / Q000494:pharmacology*; D048448:Phenylcarbamates; D011188:Potassium / Q000494:pharmacology*; D011409:Propylene Glycols / Q000494:pharmacology*; D014701:Veratridine / Q000494:pharmacology*
D018696:Neuroprotective Agents; D048448:Phenylcarbamates; D011409:Propylene Glycols; D018698:Glutamic Acid; D014701:Veratridine; D011188:Potassium; D000078328:Felbamate