title: Distribution of the HLA-A9 antigen family (A23, A24 and A2403).
abstract: Characterization of 50 local anti-HLA-A9 (A23 and/or A24) sera against the HLA-A2403 antigen allowed the retrospective assignment of A2403 and the verification of A23 and A24 specificities in a panel of 9196 volunteer bone marrow donors. The six A2403 positive subjects identified were confirmed by PCR using four sequence-specific primer mixtures. Population analysis showed the distribution and HLA-A/B linkage disequilibrium of HLA-A23 and A24 to be typical of a Northern European Caucasoid population. HLA-A2403 has a phenotype frequency of 0.00065 (gene frequency-0.00033) and is in linkage disequilibrium with HLA-B63 and possibly B35.
authors.affiliation: Regional Tissue Typing Laboratory, National Blood Transfusion Service (Wales), Cardiff, U.K.
authors.forename: M
authors.initials: M
authors.lastname: Thomas
authors.forename: J
authors.initials: J
authors.lastname: Street
authors.forename: H
authors.initials: H
authors.lastname: Fussell
authors.forename: M
authors.initials: M
authors.lastname: Guttridge
authors.forename: C
authors.initials: C
authors.lastname: Darke
mesh_terms: D001853:Bone Marrow / Q000276:immunology*; D005060:Europe; D005787:Gene Frequency; D008040:Genetic Linkage; D015234:HLA-A Antigens / Q000235:genetics / Q000276:immunology*; D006801:Humans; D014019:Tissue Donors
chemical_list: D015234:HLA-A Antigens; C037709:HLA-A9 antigen