title: Inhibition of succinate-ubiquinone reductase by nitrosalicyl-N-alkylamides.
abstract: The abilities of eight nitrosalicyl-N-alkylamides to inhibit succinate-ubiquinone reductase were compared. These compounds possess both a nitro group at 3- or 5-position of the benzyl ring, and a methyl, decyl, dodecyl or tetradecyl group subsituted for the amide hydrogen of salicylamide. The result shows the following: (a) 3-Nitrosalicyl-N-alkylamides are stronger inhibitors than 5-nitrosalicyl-N-alkylamides when they have the same alkyl group. (b) The inhibitory abilities of both 3-and 5-nitrosalicyl-N-alkylamides increase with increasing alkyl group length. (c) Kinetic data show that the inhibition by 3-nitrosalicyl-N-tetradecylamide is noncompetitive with respect to the electron acceptor Q2.
authors.affiliation: Institute of Biophysics, Academia Sinica, Beijing, China.
authors.forename: C
authors.initials: C
authors.lastname: Liu
authors.forename: J
authors.initials: J
authors.lastname: Xu
authors.forename: Y
authors.initials: Y
authors.lastname: Xiao
authors.forename: L
authors.initials: L
authors.lastname: Gu
mesh_terms: D000818:Animals; D042963:Electron Transport Complex II; D007700:Kinetics; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors*; D009206:Myocardium / Q000201:enzymology; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D012457:Salicylamides / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors*; D013552:Swine
chemical_list: D009097:Multienzyme Complexes; D012457:Salicylamides; D010088:Oxidoreductases; D042963:Electron Transport Complex II; D013385:Succinate Dehydrogenase