Multiple-dose pharmacokinetics of cefpirome in long-term hemodialysis with high-flux membranes.
Cefpirome is a cephalosporin eliminated primarily by kidneys that requires dosage reduction in patients with renal failure. The pharmacokinetic parameters were studied in 10 patients with end-stage renal disease who were receiving hemodialysis. Repeated intravenous administration of 2 gm cefpirome three times a week resulted in trough levels of 12.2 +/- 5.4 micrograms/ml and peak serum concentrations of 99.6 +/- 82.1 micrograms/ml. After 3 1/2 hours of hemodialysis with polysulfone high-flux membranes, 62.3% +/- 23.3% of cefpirome was removed. The interdialytic half-life was 9.35 +/- 0.99 hours, and the intradialytic half-life was 2.02 +/- 0.7 hours.
Thalhammer
F
F
Department of Infectious Diseases, University of Vienna, Austria.
Schmaldienst
S
S
Elmenyawi
I
I
Atteneder
M
M
Burgmann
H
H
Hollenstein
U
U
Georgopoulos
A
A
Graninger
W
W
Putz
D
D
Rosenkranz
A R
AR
Mayer
G
G
Hörl
W H
WH
Breyer
S
S
D000328:Adult; D000368:Aged; D002511:Cephalosporins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007676:Kidney Failure, Chronic / Q000628:therapy; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D011108:Polymers; D006435:Renal Dialysis / Q000379:methods*; D013450:Sulfones; D000097572:Cefpirome
D002511:Cephalosporins; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; D000097572:Cefpirome; C017662:polysulfone P 1700