Histamine-releasing factors.
There is increasing evidence that human basophils accumulate at sites of chronic inflammation, and, in particular, in allergic asthma. Investigators have, therefore, become very interested in identifying proteins that activate these cells. Recently, the gene encoding a candidate for this function, a novel molecule, the IgE-dependent histamine-releasing factor, was cloned.
MacDonald
S M
SM
Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA. smacdona@welchlink.welch.jhu.edu
D000818:Animals; D014408:Biomarkers, Tumor; D006636:Histamine Release; D006801:Humans; D008222:Lymphokines; D000090324:Tumor Protein, Translationally-Controlled 1
D014408:Biomarkers, Tumor; D008222:Lymphokines; D000090324:Tumor Protein, Translationally-Controlled 1