Psoriasis and bacterial superantigens--formal or causal correlation?
Superantigens have recently been identified as candidates for triggering crucial events in the development of psoriasis. Seemingly contradictory observations may complement each other when discussed in the context of the concept of an effector cell cascade initiated by bacterial superantigens that eventually brings about disruption of peripheral tolerance of a CD8+ T-cell subset.
Boehncke
W H
WH
Dept of Dermatology, Frankfurt University School of Medicine, Germany.
D000483:Alleles; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology* / Q000502:physiology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D005098:Exotoxins / Q000502:physiology; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000502:physiology; D051379:Mice; D016513:Mice, SCID; D011565:Psoriasis / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000502:physiology; D012867:Skin / Q000276:immunology; D016038:Skin Transplantation; D013291:Streptococcus / Q000737:chemistry; D018089:Superantigens / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology
D000942:Antigens, Bacterial; D005098:Exotoxins; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D016693:Receptors, Antigen, T-Cell, alpha-beta; D018089:Superantigens; D018799:Intercellular Adhesion Molecule-1