title: Extracellular alkaline phosphatase activity as a possible marker for wound healing: a preliminary report.
abstract: OBJECTIVE
  This study evaluated the use of extracellular alkaline phosphatase activity as a marker of wound healing.
  
  
  METHODS
  Fifteen 8-week-old Wistar rats, weighing 180 to 220 g and of both sexes, made up the material of this study. Histopathologic aspects of the healing of full-thickness of wounds created on the dorsal skin of these rats were studied by means of alkaline phosphatase (ALP) enzyme histochemistry and routine microscopy.
  
  
  RESULTS
  The current study showed an exclusive localization of extracellular ALP activity in the regions of granulation tissue formation. This localization was time related, and decreased as healing progressed.
  
  
  CONCLUSIONS
  Although the biologic significance of ALP is still obscure, use of extracellular ALP activity as a simple and reliable histochemical process marker of the skin wound healing is proposed.
authors.affiliation: First Department of Oral and Maxillofacial Surgery, School of Dentistry, Niigata University, Japan.
authors.forename: G
authors.initials: G
authors.lastname: Alpaslan
authors.forename: T
authors.initials: T
authors.lastname: Nakajima
authors.forename: Y
authors.initials: Y
authors.lastname: Takano
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers; D005110:Extracellular Space / Q000201:enzymology*; D005260:Female; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000502:physiology*
chemical_list: D015415:Biomarkers; D000469:Alkaline Phosphatase