title: [C-type hepatitis in spontaneous intracerebral hemorrhage].
abstract: The prevalence of hepatitis C virus (HCV) in 139 cases of spontaneous intracerebral hemorrhage (ICH) was investigated with regard to a diagnosis of hypertension. Patients under 30 and over 79 years of age were omitted from this study, and those with complicating malignancies and undergoing anti-coagulation or antiplatelet therapy were also excluded. The prevalence of HCV was significantly higher among the ICH group as a whole (19 out of 139 cases, p < 0.05) especially in the non-hypertensive group (7 out of 29 cases, p < 0.01), compared to the control group (7 out of 140 cases without ICH). The non-hypertensive HCV-positive group (7 cases) had significantly higher GOT and GPT levels, prolonged PT and a-PTT values, and lower platelet counts, compared to the hypertensive HCV-negative group (74 cases). The HCV antibody titers did not differ among the HCV-positive groups. The results suggest that chronic hepatitis due to HCV infection is a major risk factor for spontaneous intracerebral hemorrhage, especially in non-hypertensive patients.
authors.affiliation: Department of Neurosurgery, Takeda General Hospital, Aizuwakamatsu, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Aiba
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Koike
authors.forename: Y
authors.initials: Y
authors.lastname: Arakawa
mesh_terms: D000328:Adult; D000368:Aged; D002543:Cerebral Hemorrhage / Q000209:etiology*; D002908:Chronic Disease; D005260:Female; D006526:Hepatitis C / Q000150:complications* / Q000453:epidemiology*; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors