title: Healing of the esophageal suture line: does it differ from the rest of the alimentary tract?
abstract: We investigated the healing pattern of the esophageal suture line in rats. Fifty male wistar rats were divided into experimental (n = 40) and control (n = 10) groups. The rats in the experimental group underwent esophogostomy at the abdominal esophagus, which was immediately sutured, and sacrificed 2, 4, 7 and 14 days later. Esophageal bursting pressure and hydroxyproline content were determined in both groups. The measured bursting pressures in the experimental group on days 2, 4, 7 and 14 were (mean +/- SD) 78 +/- 35, 95 +/- 12, 1,163 +/- 98 and 1,224 +/- 22 cm H2O, respectively, and 1,308 +/- 87 cm H2O in the control group (P <0.05 vs. all the experimental group values). The hydroxyproline content in the experimental group on days 2, 4, 7 and 14 were 13.9 +/- 2.1, 12.53 +/- 2.68, 15.6 +/- 0.85 and 17.75 +/- 5.65 microg/mg, respectively, and 27.88 +/- 2.5 microg/mg in the control group (P <0.05 vs. all the experimental group values). We conclude that the esophagus demonstrates the same healing pattern as the rest of the alimentary tract, but its healing seems to occur at a slower pace.
authors.affiliation: Department of Surgery A, Rabin Medical Center, Petah Tikva, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Levi
authors.forename: E
authors.initials: E
authors.lastname: Ramadan
authors.forename: E
authors.initials: E
authors.lastname: Gelber
authors.forename: R
authors.initials: R
authors.lastname: Koren
authors.forename: C
authors.initials: C
authors.lastname: Chaimoff
authors.forename: S
authors.initials: S
authors.lastname: Kyzer
mesh_terms: D000818:Animals; D004946:Esophagostomy; D004947:Esophagus / Q000473:pathology / Q000502:physiology / Q000601:surgery*; D006909:Hydroxyproline / Q000032:analysis; D008297:Male; D011312:Pressure; D051381:Rats; D017208:Rats, Wistar; D013536:Suture Techniques; D013718:Tensile Strength; D013997:Time Factors; D014945:Wound Healing
chemical_list: D006909:Hydroxyproline