Pituitary adenylate cyclase-activating polypeptide induces gene expression of the catecholamine synthesizing enzymes, tyrosine hydroxylase, and dopamine beta-hydroxylase in cultured porcine adrenal medullary chromaffin cells.
Isobe
K
K
Department of Clinical Pathology, University of Tsukuba, Ibaraki, Japan. k-isobe@md.tsukuba.ac.jp
Yukimasa
N
N
Nakai
T
T
Takuwa
Y
Y
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000313:Adrenal Medulla / Q000201:enzymology*; D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D002478:Cells, Cultured; D019439:Chromaffin Cells / Q000201:enzymology*; D000242:Cyclic AMP / Q000378:metabolism; D004299:Dopamine beta-Hydroxylase / Q000096:biosynthesis*; D004533:Egtazic Acid / Q000494:pharmacology; D015870:Gene Expression / Q000187:drug effects; D009479:Neuropeptides / Q000494:pharmacology*; D018377:Neurotransmitter Agents / Q000494:pharmacology; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D014176:Protein Biosynthesis / Q000187:drug effects; D011493:Protein Kinase C / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis; D016755:Proto-Oncogene Proteins c-jun / Q000096:biosynthesis; D012333:RNA, Messenger / Q000096:biosynthesis; D013552:Swine; D014158:Transcription, Genetic / Q000187:drug effects; D014446:Tyrosine 3-Monooxygenase / Q000096:biosynthesis*
D002395:Catecholamines; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; D012333:RNA, Messenger; D004533:Egtazic Acid; D000242:Cyclic AMP; D014446:Tyrosine 3-Monooxygenase; D004299:Dopamine beta-Hydroxylase; D011493:Protein Kinase C; D015056:1-Methyl-3-isobutylxanthine