title: Cytotoxicity and suppression of immunoglobulin production against human Namalwa cells caused by oxidized cholesterol.
abstract: The effects of oxidized cholesterols on proliferation and IgM production of human lymphoblastoid Namalwa cells were examined. An oxidized cholesterol mixture, in contrast to cholesterol, was a potent cytotoxin to Namalwa cells. Among oxidized cholesterols examined, 25-hydroxycholesterol was the most cytotoxic. However, no oxidized cholesterol examined suppressed IgM production, although cholestanetriol and 7-ketocholesterol did suppress it. Thus, oxidized cholesterols are cytotoxic to lymphocytes, while the influence on the immunoglobulin production may be marginal.
authors.affiliation: Laboratory of Food Science, Kyushu University, School of Agriculture, Fukuoka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Osada
authors.forename: T
authors.initials: T
authors.lastname: Kodama
authors.forename: N
authors.initials: N
authors.lastname: Matsuo
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Sugano
mesh_terms: D002051:Burkitt Lymphoma / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002784:Cholesterol / Q000494:pharmacology*; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis*; D008214:Lymphocytes / Q000187:drug effects*; D010084:Oxidation-Reduction; D014407:Tumor Cells, Cultured
chemical_list: D007075:Immunoglobulin M; D002784:Cholesterol