title: Donor origin of a posttransplant liver allograft malignancy identified by fluorescence in situ hybridization for the Y chromosome and DNA genotyping.
abstract: Posttransplantation malignancy in the allograft is a rare complication of orthotopic liver transplantation. In the described case, an abnormal T-tube cholangiogram, performed 6 months after orthotopic liver transplantation between a male donor and a female recipient, prompted needle liver biopsy. A moderately differentiated adenocarcinoma was found. Fluorescence in situ hybridization for the Y chromosome indicated male origin of malignancy. Donor-related disease was confirmed by comparative DNA analysis of genomic sequences from the donor liver, associated tumor, and recipient peripheral blood. Results of these investigations qualified the recipient for a second liver transplant.
authors.affiliation: Department of Gastroenterology, Southern California Permanente Medical Group, Kaiser Los Angeles Medical Center, 90027, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Donovan
authors.forename: F A
authors.initials: FA
authors.lastname: Simmons
authors.forename: K T
authors.initials: KT
authors.lastname: Esrason
authors.forename: M
authors.initials: M
authors.lastname: Jamehdor
authors.forename: R W
authors.initials: RW
authors.lastname: Busuttil
authors.forename: J M
authors.initials: JM
authors.lastname: Novak
authors.forename: W W
authors.initials: WW
authors.lastname: Grody
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology*; D005260:Female; D005838:Genotype; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008113:Liver Neoplasms / Q000209:etiology*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D014019:Tissue Donors; D014184:Transplantation, Homologous; D014998:Y Chromosome