Efficacy of lasalocid against murine Pneumocystis carinii pneumonitis.
The efficacy of the ionophore lasalocid against Pneumocystis carinii pneumonitis in corticosteroid-immunosuppressed Sprague-Dawley rats was investigated. Lasalocid was effective in the prevention of the pneumonitis in a dose-dependent manner. At dosages of 0, 5, 10, and 20 mg/kg/day, P. carinii infection rates were 92, 60, 20, and 0%, respectively, during dexamethasone immunosuppression. Also, lasalocid compared favorably with other drugs known to have anti-P. carinii activity, including trimethoprim-sulfamethoxazole, atovaquone, and dapsone-trimethoprim.
OZ
H S
HS
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis Tennessee 38105, USA.
Hughes
W T
WT
Rehg
J E
JE
D000818:Animals; D005260:Female; D007476:Ionophores / Q000627:therapeutic use*; D007832:Lasalocid / Q000627:therapeutic use*; D011020:Pneumonia, Pneumocystis / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley
D007476:Ionophores; D007832:Lasalocid