title: [Design of topically resorptive interferon drugs].
abstract: The current data on the development and design of topically resorptive interferon drugs are summarized. In many cases it is advisable to use topically resorptive interferon agents which allows them to topically affect a clinical process, to avoid negative sequelae seen when high-dose interferon is unjustifiably systematically given, by reducing its use to a minimum. Interferon is known to be one of the best antiviral agent, besides, it produces marked antimicrobial and antitumor effects. Whether interferon as a component of drugs can be stabilized by axillaries of various chemical nature which act as stabilizers, promoters, and carriers is dealt with. The topically resorptive formulations designed in terms of biopharmaceutical factors are described. The advantages of topically resorptive agents over other drugs are shown and hence they can be widely used in practical medicine.
authors.affiliation: NII of Grippe RAMN, Saint-Petersburg.
authors.forename: S M
authors.initials: SM
authors.lastname: Shchekanova
authors.forename: S F
authors.initials: SF
authors.lastname: Protasova
mesh_terms: D000042:Absorption; D000287:Administration, Topical; D000998:Antiviral Agents / Q000493:pharmacokinetics*; D015195:Drug Design; D004341:Drug Evaluation / Q000379:methods; D006801:Humans; D007372:Interferons / Q000493:pharmacokinetics*
chemical_list: D000998:Antiviral Agents; D007372:Interferons