Conscious sedation for interventional neuroradiology: a comparison of midazolam and propofol infusion.
OBJECTIVE
The aim of this study was to compare two conscious sedation techniques, midazolam (M) and propofol (P), for interventional neuroradiology by assessment of the incidence of complications and satisfaction scores.


METHODS
Forty patients were randomized to receive 0.75 micrograms.kg-1 fentanyl and a M or P bolus followed by an infusion (M 15 micrograms.kg-1 + 0.5 micrograms.kg-1.min-1; P 0.5 mg.kg-1 + 25 micrograms.kg-1 min-1). The incidences of complications and untoward events requiring intervention were documented. These included respiratory depression, excessive pain, inappropriate movements and the inability to examine the patient. The satisfaction of the anaesthetic technique from the perspective of both the neuroradiologist and the patient was scored.


RESULTS
The incidence and types of complications were no different between the two groups. Pain occurred in 12 patients (6M, 6P), inappropriate movements in 17 (7M, 10P) and respiratory changes in 10 patients (2M, 8P).


CONCLUSIONS
Both techniques were satisfactory and the incidence of complications was similar for both groups.
Manninen
P H
PH
Department of Anaesthesia, Toronto Hospital, University of Toronto, Ontario, Canada.
Chan
A S
AS
Papworth
D
D
D000328:Adult; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects; D001007:Anxiety / Q000517:prevention & control; D001291:Attitude of Health Personnel; D002561:Cerebrovascular Disorders / Q000628:therapy*; D016292:Procedural Sedation / Q000009:adverse effects / Q000379:methods*; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage; D006801:Humans; D015994:Incidence; D008297:Male; D008874:Midazolam / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D009068:Movement; D010146:Pain / Q000209:etiology; D017060:Patient Satisfaction; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects; D011595:Psychomotor Agitation / Q000209:etiology; D015642:Radiology, Interventional; D012119:Respiration / Q000187:drug effects
D018686:Anesthetics, Intravenous; D008874:Midazolam; D005283:Fentanyl; D015742:Propofol