The non-obese diabetic (NOD) mouse: an animal model for autoimmune thyroiditis.
The NOD mouse, an ideal model for insulin-dependent diabetes mellitus, is also useful to study the pathogenesis of autoimmune thyroiditis. Spontaneous thyroiditis greatly varies in frequency among NOD colonies, but Hashimoto-like thyroiditis can be induced in two experimental models: goiter involution after iodide administration and immunization by TSH receptor, described hereunder.
Many
M C
MC
Laboratory of Histology, Medical School, Catholic University of Louvain, Brussels, Belgium. Many
Maniratunga
S
S
Denef
J F
JF
D000818:Animals; D003922:Diabetes Mellitus, Type 1; D004195:Disease Models, Animal; D006801:Humans; D007114:Immunization; D007454:Iodides / Q000008:administration & dosage; D051379:Mice; D016688:Mice, Inbred NOD; D011989:Receptors, Thyrotropin / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000276:immunology
D007454:Iodides; D011989:Receptors, Thyrotropin