title: Nucleic acid based sensors.
abstract: Nucleic acids may be analyte or molecular recognition elements in biosensors. Both aspects merge in the genosensor approach, where detection of special sequences is facilitated by hybridization of a target nucleic acid to a complementary immobilized template. All three roles of nucleic acids in biosensors are discussed and the state of sensor development reviewed. With the invention of evolutionary synthesis strategies applied to nucleic acids new types of biomolecular receptors are accessible. The impact of aptamers and ribozymes on biosensor development is discussed.
authors.affiliation: Institute for Biochemistry and Molecular Physiology, University of Potsdam, Max-Delbrück-Center of Molecular Medicine, Berlin, Germany.
authors.forename: F F
authors.initials: FF
authors.lastname: Bier
authors.forename: J P
authors.initials: JP
authors.lastname: Fürste
mesh_terms: D000327:Adsorption; D015374:Biosensing Techniques; D015342:DNA Probes; D004268:DNA-Binding Proteins / Q000378:metabolism; D004563:Electrochemistry; D005456:Fluorescent Dyes; D007700:Kinetics; D009693:Nucleic Acid Hybridization; D009696:Nucleic Acids / Q000032:analysis / Q000378:metabolism*; D012313:RNA / Q000378:metabolism; D016337:RNA, Catalytic / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism; D013698:Templates, Genetic
chemical_list: D015342:DNA Probes; D004268:DNA-Binding Proteins; D005456:Fluorescent Dyes; D009696:Nucleic Acids; D016337:RNA, Catalytic; D016601:RNA-Binding Proteins; D012313:RNA