title: Polymer- versus silica-based separation media: elimination of nonspecific interactions in the chiral recognition process through functional polymer design.
abstract: A novel chiral stationary phase that contains a new chiral selector based on L-valine-3,5-dimethylanilide attached to monodisperse poly(glycidyl methacrylate-co-ethylene dimethacrylate) beads has been prepared. The polymeric separation medium provides greatly enhanced enantioselectivities and reduced retention times when compared to the analogous silica-based chiral stationary phase in the separation of the enantiomers of 3,5-dinitrobenzamido derivatives of alpha-amino acids under normal-phase HPLC conditions. Separation factors (alpha) of up to 7 were achieved with the polymeric separation medium, which is also useful for the separation of large samples under overload conditions.
authors.affiliation: Baker Laboratory, Department of Chemistry, Comell University, Ithaca, New York 14853-1301, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: F
authors.initials: F
authors.lastname: Svec
authors.forename: J M
authors.initials: JM
authors.lastname: Fréchet
authors.forename: K N
authors.initials: KN
authors.lastname: Juneau
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000379:methods*; D002845:Chromatography / Q000379:methods; D011108:Polymers; D012822:Silicon Dioxide; D013237:Stereoisomerism
chemical_list: D011108:Polymers; D012822:Silicon Dioxide