title: Endometrial biopsy in DUB.
abstract: OBJECTIVE
  To determine the incidence of abnormal endometrial histology in women with dysfunctional uterine bleeding and to evaluate the predictive value of risk factors for endometrial cancer in women with dysfunctional uterine bleeding (DUB).
  
  
  METHODS
  We conducted a retrospective review of 310 women with DUB who underwent endometrial biopsy. The risk factors for abnormal endometrial histology included menstrual cycle irregularity, diabetes, nulliparity, hypertension, weight > or = 100 kg and age > or = 40 years. The incidence of endometrial abnormalities was determined, and the predictive value of combinations of risk factors was assessed using stepwise logistic regression.
  
  
  RESULTS
  Twenty-one patients (6.7%) had abnormal endometrial biopsies. Menstrual cycle irregularity (P = .0001), age > or = 40 years (p = .022) and hypertension (P = .058) were independently significant risk factors for abnormal endometrial histology. The probability of abnormal endometrial histology in a premenopausal woman with DUB whose cycle was regular was < 1%. The presence of menstrual cycle irregularity increased the probability of abnormal endometrial histology to 14.3%.
  
  
  CONCLUSIONS
  The patient who presents with DUB and a history of menstrual cycle irregularity warrants an endometrial biopsy, regardless of age. The current clinical emphasis on age (especially > or = 40 years) as justification for endometrial biopsy is unwarranted in patients with DUB. More careful selection of patients for endometrial biopsy will mean that fewer women are unnecessarily exposed to the discomfort and risk of complications associated with endometrial biopsy.
authors.affiliation: Department of Obstetrics and Gynaecology, Dalhousie University, Halifax, Nova Scotia, Canada.
authors.forename: S J
authors.initials: SJ
authors.lastname: Ash
authors.forename: S A
authors.initials: SA
authors.lastname: Farrell
authors.forename: G
authors.initials: G
authors.lastname: Flowerdew
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy / Q000191:economics / Q000592:standards*; D017046:Cost Savings; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D004717:Endometrium / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology; D015994:Incidence; D008599:Menstruation Disturbances / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D012307:Risk Factors; D014592:Uterine Hemorrhage / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology