Essential fatty acid deficiency and bone fragility in rats.
This study demonstrates the effect of essential fatty acid deficiency on the postnatal skeletal development in the rat. Four groups (n = 10) of newborn Wistar rats were fed diets containing high and low proportions of essential fatty acids in the lipid fraction until day 16 after birth. Suckled littermates were used as controls. X-ray and histological studies showed the occurrence of multiple pathological fractures of the long bones in 1-month-old rats fed a diet deprived of essential fatty acids. No effect of high (51,000 IU/100 g diet) and low (5,100 IU/100 g diet) concentrations of vitamin D2 was observed in our experiment. Thus, these data suggest the importance of essential fatty acids for bone pathology in the rat.
Stĕpánková
R
R
Division of Immunology and Gnotobiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Funda
D P
DP
Smetana
K
K
D000818:Animals; D001848:Bone Diseases, Developmental / Q000473:pathology*; D004041:Dietary Fats / Q000494:pharmacology*; D004872:Ergocalciferols / Q000494:pharmacology; D005227:Fatty Acids / Q000494:pharmacology*; D005264:Femoral Fractures / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013978:Tibial Fractures / Q000473:pathology
D004041:Dietary Fats; D004872:Ergocalciferols; D005227:Fatty Acids