title: Practical application of a scan-rotate equalization geometry to mammography.
abstract: The presence of dense fibroglandular tissue within the breast is the most significant cause of failure to detect breast cancer with mammography. The dense tissue often produces a range of exposure which exceeds the useful dynamic range of film-screen mammography. It has been shown that equalization radiography overcomes the latitude limitations of film-screen imaging. Equalization compensates for regional variations in x-ray transmission within the patient through spatial modulation of the entrance exposure. We have proposed rotary scanning equalization radiography (RSER), a scan-rotate geometry for efficient equalization radiography. In RSER the image receptor is exposed by repeated scans of a source-modulated fan beam. The fan beam is rotated with respect to the patient between scans. Numerical simulations and theoretical analysis have shown that the superposition of exposure from appropriately modulated fan beams at a variety of angles is an entrance exposure that effectively equalizes the film exposure. The design and characteristics of a prototype RSER imaging system are described. Anthropomorphic breast phantom images are used to determine the improvement in image contrast obtained with RSER, the expected tube loading, and the presence of artifacts. RSER increases the fraction of the breast imaged with high contrast (at least 90% of peak gradient) from 46% (conventional mammography) to 80%. Subjective examination of the phantom images show that RSER achieves image quality very similar to that of much less efficient equalization geometries with only 2.7 times greater tube loading than conventional mammography. As predicted by theoretical analysis of exposure artifacts in RSER, the prototype RSER system is relatively immune to artifacts. Exposure artifacts were demonstrated for extreme variations in x-ray transmission within the patient. These results show that RSER is an efficient, practical means of overcoming the latitude limitations of film-screen mammography, and improving the detection of breast cancer.
authors.affiliation: Department of Medical Biophysics and Imaging Research, Sunnybrook Health Science Centre, University of Toronto, Canada.
authors.forename: J M
authors.initials: JM
authors.lastname: Sabol
authors.forename: I C
authors.initials: IC
authors.lastname: Soutar
authors.forename: D B
authors.initials: DB
authors.lastname: Plewes
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D001940:Breast / Q000033:anatomy & histology / Q000473:pathology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008327:Mammography / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D019047:Phantoms, Imaging; D011856:Radiographic Image Enhancement / Q000379:methods; D013679:Technology, Radiologic