Prognostic role of immunosuppressive acidic protein in advanced ovarian cancer.
OBJECTIVE
Our purpose was to investigate immunosuppressive acidic protein in the prognostic characterization of advanced ovarian cancer.


METHODS
Serum levels of immunosuppressive protein were prospectively measured in 80 patients with untreated ovarian carcinoma. To evaluate the prognostic significance of immunosuppressive acidic protein levels, cutoff points were studied every 50 micrograms/ml between 450 and 1350 micrograms/ml.


RESULTS
Pretreatment immunosuppressive acidic protein levels were not significantly associated with stage, histotype, grade of differentiation, postoperative residual tumor, and response to chemotherapy. The most significant association with survival was observed at a cutoff value of 1100 micrograms/ml (p = 0.0089). In the univariate analysis for overall survival, International Federation of Gynecology and Obstetrics stage and immunosuppressive acidic protein status were found to have a role in predicting ovarian cancer prognosis. In the multivariate analysis only immunosuppressive acidic protein status was significantly associated with survival. A statistical correlation was found between serum levels and overall survival (p = 0.0104, chi 2 6.56), including immunosuppressive acidic protein as a continuous variable.


CONCLUSIONS
Our data suggest that immunosuppressive acidic protein assay is a potentially useful tool in the prognostic characterization of advanced ovarian cancer.
Scambia
G
G
Department of Gynecology and Obstetrics, Catholic University(a), Rome, Italy.
Foti
E
E
Ferrandina
G
G
Leone
F P
FP
Gadducci
A
A
Benedetti-Panici
P
P
Mancuso
S
S
D018394:CA-125 Antigen / Q000032:analysis; D018450:Disease Progression; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009363:Neoplasm Proteins / Q000378:metabolism*; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D011446:Prospective Studies; D016019:Survival Analysis
D018394:CA-125 Antigen; D009363:Neoplasm Proteins; C030193:immunosuppressive acidic protein