Experimental autoimmune myositis in SJL/J mice produced by immunization with syngeneic myosin B fraction. Transfer by both immunoglobulin G and T cells.
An experimental autoimmune myositis (EAM) was produced by immunizing SJL/J mice with the myosin B (MB) fraction of the syngeneic muscle. Immunoblot analysis of the IgG of the EAM mice demonstrated antibodies against a variety of muscle proteins. The condition was then transferred to normal mice by both injecting immunoglobulin G or T cells from the EAM mice. This is the first model of transferrable EAM caused by syngeneic muscle fraction, and it has an unique resemblance to human inflammatory myopathies involving both humoral and cellular immune mechanisms.
Matsubara
S
S
Department of Neurology, Tokyo Metropolitan Neurological Hospital, Japan.
Okumura
S
S
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D005591:Chemical Fractionation; D005260:Female; D007114:Immunization; D007074:Immunoglobulin G / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D009218:Myosins / Q000276:immunology*; D009220:Myositis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D007074:Immunoglobulin G; D009218:Myosins