Surgery for refractory glaucoma.
OBJECTIVE
To determine the surgical outcome of mitomycin trabeculectomy in patients with refractory glaucoma.


METHODS
Sixty-six eyes of 52 patients with refractory glaucoma underwent mitomycin trabeculectomy. Mitomycin was applied for five minutes only once during trabeculectomy. The follow-up period was six to 61 months.


RESULTS
Cumulative success probability was calculated using Kaplan-Meier life-table analysis assuming the cut-off postoperative IOP to be 20 mmHg or IOP reduction by at least 20% in eyes with preoperative IOP 24 mmHg. At the end of 61-month follow-up the success probability was 80% +/- 6% without postoperative ocular hypotensive medication (complete success) and was 95% +/- 3% regardless of postoperative antiglaucoma medication (overall success), respectively.


CONCLUSIONS
The data suggest that mitomycin trabeculectomy is efficacious in reducing IOP in patients with refractory glaucoma.
Kitazawa
Y
Y
Department of Ophthalmology, Gifu University School of Medicine, Japan.
Yamamoto
T
T
Sawada
A
A
Hagiwara
Y
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D017024:Chemotherapy, Adjuvant; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D019384:Nucleic Acid Synthesis Inhibitors / Q000008:administration & dosage*; D011183:Postoperative Complications; D012307:Risk Factors; D014130:Trabeculectomy; D016896:Treatment Outcome
D019384:Nucleic Acid Synthesis Inhibitors; D016685:Mitomycin