title: Intensive care management of paediatric organ donors and its effect on post-transplant organ function.
abstract: OBJECTIVE
  1. To document the clinical course of paediatric beating heart organ donors. 2. To evaluate the effect of the ICU management of pediatric donors on the immediate function of transplanted organs. 3. To examine the validity of current donor selection criteria.
  
  
  METHODS
  Retrospective chart review and case series study.
  
  
  METHODS
  Multidisciplinary ICU of tertiary referral paediatric hospital.
  
  
  METHODS
  All patients who became solid organ donors between January 1980 and July 1990.
  
  
  METHODS
  1. Incidence of major physiological abnormalities of the cardiovascular, pulmonary, renal and metabolic systems. 2. Number of organs retrieved and transplanted, reasons for non-transplantation of donated organs. 3. Immediate post-transplant function of transplanted organs.
  
  
  RESULTS
  Seventy-seven organ donors were identified from whom 134 kidneys, 31 livers and 12 hearts were transplanted. Sixty (78%) patients developed diabetes insipidus. Sustained hypotension occurred in 41 (53.2%) and was commoner in patients treated with inotropic agents in the presence of a low central venous pressure and in patients with diabetes insipidus who did not receive anti-diuretic hormone replacement. Twenty-seven patients suffered at least one cardiac arrest. The data on post-transplant function were obtained for 129 kidneys (from 70 donors) 30 livers and 9 hearts. Fifty-two kidneys, 10 livers and 2 hearts were transplanted from donors who had suffered at least one cardiac arrest without apparent adverse effect on post-transplant organ function. Thirty-six kidneys from 31 donors suffered either acute tubular necrosis (ATN) or primary non-function. The donors of these organs spent longer in ICU (60.6 +/- 45.7 h versus 41.8 +/- 30.1 h p = 0.045) and had a higher mean maximum serum sodium concentration (163.4 +/- 10.9 versus 158.5 +/- 9.5 mmol/l p = 0.05) than those without these complications. The serum creatinine concentration and degree of inotropic support did not predict post-transplant function. Standard biochemical tests for hepatic function, the dose of inotropic agent received, time in ICU and incidence of hypotension did not predict post-transplant liver function.
  
  
  CONCLUSIONS
  Aggressive fluid resuscitation and management of diabetes insipidus may promote stability in paediatric organ donors. Donor cardiac arrest does not alter the ICU course or compromise post-transplant organ function. The current criteria used for donor selection failed to predict post-transplant organ function and their use may increase organ wastage.
authors.affiliation: Department of Critical Care Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Finfer
authors.forename: D
authors.initials: D
authors.lastname: Bohn
authors.forename: D
authors.initials: D
authors.lastname: Colpitts
authors.forename: P
authors.initials: P
authors.lastname: Cox
authors.forename: F
authors.initials: F
authors.lastname: Fleming
authors.forename: G
authors.initials: G
authors.lastname: Barker
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D003422:Critical Care / Q000379:methods*; D003919:Diabetes Insipidus / Q000209:etiology; D005260:Female; D006323:Heart Arrest / Q000209:etiology; D006801:Humans; D007022:Hypotension / Q000209:etiology; D007223:Infant; D015278:Intensive Care Units, Pediatric; D007683:Kidney Tubular Necrosis, Acute / Q000209:etiology; D008297:Male; D016377:Organ Transplantation / Q000009:adverse effects* / Q000502:physiology*; D018579:Patient Selection; D012189:Retrospective Studies; D013997:Time Factors; D014019:Tissue Donors; D009927:Tissue and Organ Procurement / Q000379:methods*
chemical_list: D003404:Creatinine