Sulfadiazine-induced sialadenitis.
OBJECTIVE
To present a case of sialadenitis induced by sulfadiazine.


METHODS
A 50-year-old man with bronchitis developed swelling of the parotid glands and floor of the mouth as well as plugging in his ears 2 hours after ingestion of Bronco-aseptilex (sulfadiazine, cyclamate, and guaiacol). Skin-prick tests performed with serial dilutions of sulfadiazine and Bronco-aseptilex were all negative. We then performed oral challenge tests with Bronco-aseptilex, sulfadiazine, and other compounds of the commercial syrup. Enlargement of the salivary glands was observed after oral challenge tests with Bronco-aseptilex and sulfadiazine.


CONCLUSIONS
We describe a patient who developed drug-induced sialadenitis. The oral challenge test confirmed that sulfadiazine was the etiologic agent.
Añíbarro
B
B
Department of Internal Medicine, Hospital Virgen de la Luz, Cuenca, Spain.
Fontela
J L
JL
D000890:Anti-Infective Agents / Q000009:adverse effects*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D012793:Sialadenitis / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D013411:Sulfadiazine / Q000009:adverse effects*
D000890:Anti-Infective Agents; D005938:Glucocorticoids; D013411:Sulfadiazine; D008775:Methylprednisolone