EI-1511-3, -5 and EI-1625-2, novel interleukin-1 beta converting enzyme inhibitors produced by Streptomyces sp. E-1511 and E-1625. I. Taxonomy of producing strain, fermentation and isolation.
EI-1511-3, -5 and EI-1625-2, novel interleukin-1 beta converting enzyme (ICE) inhibitors, were isolated from the culture broths of Streptomyces sp. E-1511 and E-1625. EI-1511-3, -5 and EI-1625-2 selectively inhibited the recombinant human ICE activity with IC50 values of 0.09, 0.38 and 0.2 microM, respectively. Taxonomy, fermentation of the producing strain and isolation of EI-1511-3, -5 and EI-1625-2 are described.
Tanaka
T
T
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
Tsukuda
E
E
Ochiai
K
K
Kondo
H
H
Teshiba
S
S
Matsuda
Y
Y
D000577:Amides / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D003512:Cyclohexanones / Q000302:isolation & purification*; D004791:Enzyme Inhibitors / Q000302:isolation & purification*; D005285:Fermentation; D006801:Humans; D015843:Serpins / Q000302:isolation & purification*; D013302:Streptomyces; D014764:Viral Proteins
D000577:Amides; D003512:Cyclohexanones; C103155:EI 1511-3; C103156:EI 1511-5; C103157:EI 1625-2; D004791:Enzyme Inhibitors; D015843:Serpins; D014764:Viral Proteins; C074641:interleukin-1beta-converting enzyme inhibitor