title: Granular cell tumor of the vulva: literature review and case report.
abstract: Granular cell tumors are an uncommon neoplasm of neural origin. They occur throughout the body; only about 10% are found in the vulvar region. Granular cell tumors are most frequent in the third and fourth decade of life, the African-American race, and the female. Generally, they appear as small, firm, painless, slow-growing subcutaneous nodules. They are rarely encapsulated and recurrence is common. The malignant granular cell tumor is rare, representing 1% to 2% of cases. This form is highly aggressive, unresponsive to treatment, and ultimately fatal. A third type of granular cell tumor has been described which has benign pathologic characteristics but behaves in a clinically malignant manner. The treatment of choice for all types is wide, local surgical excision. A case is described which typifies the benign type granular cell tumor.
authors.affiliation: Department of Obstetrics and Gynecology, Ochsner Clinic, New Orleans, USA.
authors.forename: J
authors.initials: J
authors.lastname: Simone
authors.forename: G T
authors.initials: GT
authors.lastname: Schneider
authors.forename: W
authors.initials: W
authors.lastname: Begneaud
authors.forename: K
authors.initials: K
authors.lastname: Harms
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis; D005260:Female; D018226:Fibroadenoma / Q000175:diagnosis; D016586:Granular Cell Tumor / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000601:surgery; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis; D014846:Vulvar Neoplasms / Q000175:diagnosis* / Q000601:surgery