Effects of Glycyrrhizae and Glycyrrhizic acid on radiation injury in mice.
The effects of Glycyrrhizae (GL) and Glycyrrhizic acid (GA) on promoting the recovery of mice from radiation injury were investigated. Two hundred ICR strain male mice, 6-8 weeks old, were randomly divided into four groups. Group A was the normal control. Group B, the experimental control, was treated with 4 Gy gamma-ray irradiation. Groups C and D, the experimental groups, were treated with 500 mg/kg of GL (oral administration) and 5 mg/kg body weight of GA (i.p.), respectively, for ten days after gamma-ray irradiation. Eight mice in each group were sacrificed on days 5, 12, 26 and 33 post irradiation to measure the weights of spleen, thymus and testes, and the biosynthetic rates of DNA in these organs. The results revealed that 4 Gy gamma-ray irradiation evidently inhibited the weights of spleen, thymus and testes, and their DNA biosynthetic rates. GL and GA enhanced the recovery of these organs in mice from the injury of gamma-ray irradiation.
Lin
I H
IH
Institute of Radiation Biology, National Tsing-Hua University, Hsinchu, Taiwan.
Hau
D M
DM
Su
M J
MJ
Chen
W C
WC
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D019695:Glycyrrhizic Acid; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011827:Radiation; D013154:Spleen / Q000187:drug effects* / Q000528:radiation effects; D013950:Thymus Gland / Q000187:drug effects* / Q000528:radiation effects
D000890:Anti-Infective Agents; D019695:Glycyrrhizic Acid; D006034:Glycyrrhetinic Acid