title: Electrospray tandem mass spectrometry of a novel series of amphipathic functionalized ether-linked di- and trisaccharides and cyclic oligosaccharides.
abstract: Electrospray mass spectrometry (ESMS) has aided the structural characterization of a novel series of amphipathic functionalized ether-linked di- and trisaccharides, composed of units of alkyl derivatives of glucofuranose and either units of glucofuranose or diacetylgalactose. The structural elucidation of a novel eight-membered macrocyclic ether-linked disaccharide and an 11-membered macrocyclic ether-linked trisaccharide was also effected using ESMS. Low-energy collision-induced dissociation MS/MS analysis of the [M + H]+ precursor ions confirmed the characteristic fingerprint patterns obtained in the conventional electrospray spectra and proved to be a specific and very sensitive method for the detection and characterization of these novel amphipathic molecules.
authors.affiliation: Department of Fisheries and Oceans, Environmental Sciences Division, St. John's, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Banoub
authors.forename: P
authors.initials: P
authors.lastname: Thibault
authors.forename: P Y
authors.initials: PY
authors.lastname: Gouéth
authors.forename: G
authors.initials: G
authors.lastname: Ronco
authors.forename: P
authors.initials: P
authors.lastname: Villa
mesh_terms: D004187:Disaccharides / Q000032:analysis; D004987:Ethers / Q000032:analysis / Q000737:chemistry; D013058:Mass Spectrometry; D015394:Molecular Structure; D009844:Oligosaccharides / Q000032:analysis*; D014312:Trisaccharides / Q000032:analysis
chemical_list: D004187:Disaccharides; D004987:Ethers; D009844:Oligosaccharides; D014312:Trisaccharides