title: Severe hyperphosphatemia following phosphate administration for bowel preparation in patients with renal failure: two cases and a review of the literature.
abstract: Two cases of severe hyperphosphatemia following phosphate bowel preparation are described and a review of the literature is presented. Impairment of renal function appears to be a risk factor in those patients without primary bowel pathology. One of our patients died, and the mortality rate combining our cases with all other reported cases is 33%. Repeated doses of phosphate bowel preparations/purgatives can be dangerous in patients with renal impairment.
authors.affiliation: Department of Nephrology, St Boniface General Hospital, Winnipeg, Manitoba, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Fine
authors.forename: J
authors.initials: J
authors.lastname: Patterson
mesh_terms: D000208:Acute Disease; D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D002400:Cathartics / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D010710:Phosphates / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood*; D051437:Renal Insufficiency / Q000097:blood* / Q000503:physiopathology; D012307:Risk Factors
chemical_list: D002400:Cathartics; D010710:Phosphates; C018279:sodium phosphate