Efficacy of closantel against Fasciola hepatica in Korean native goats.
Closantel (Flukiver), a salicylanilide antiparasitic compound, was tested in Korean native goats infected with Fasciola hepatica. The goats were administered closantel once orally at a dose of 10 mg/kg body weight. Efficacy was monitored weekly by fecal examination of all infected animals starting the second week post-treatment and continuing for 3 weeks. Closantel elicited 80.3, 97.8 and 92.7% efficacy in goats with naturally-acquired fasciolosis at the second, third and fourth week post-treatment, respectively. It elicited a 100% efficacy in goats experimentally infected with F. hepatica metacercariae and treated at 18 weeks post-infection.
Lee
C G
CG
College of Veterinary Medicine, Chonnam National University, South Korea.
Cho
S H
SH
Kim
J T
JT
Lee
C Y
CY
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D005210:Fasciola hepatica / Q000187:drug effects*; D005211:Fascioliasis / Q000188:drug therapy / Q000662:veterinary*; D005243:Feces / Q000469:parasitology; D005260:Female; D015511:Goat Diseases / Q000188:drug therapy*; D006041:Goats; D008297:Male; D010270:Parasite Egg Count / Q000662:veterinary; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000188:drug therapy / Q000662:veterinary; D012458:Salicylanilides / Q000627:therapeutic use*
D000871:Anthelmintics; D012458:Salicylanilides; C023342:closantel