title: Exclusion of one pedigree affected by adult onset primary open angle glaucoma from linkage to the juvenile glaucoma locus on chromosome 1q21-q31.
abstract: A locus for autosomal dominant juvenile onset primary open angle glaucoma (POAG) was recently assigned to chromosome region 1q21-q31. In the present study, a large Greek family with autosomal dominant adult onset POAG was investigated using microsatellite markers. Exclusion of linkage of the adult onset POAG gene to the region D1S194-D1S191 was obtained in this pedigree. Therefore, the data provide evidence that juvenile and adult onset POAG are genetically distinct disease entities.
authors.affiliation: Department of Genetics, Institute of Child Health, Athens, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Avramopoulos
authors.forename: G
authors.initials: G
authors.lastname: Kitsos
authors.forename: E
authors.initials: E
authors.lastname: Economou-Petersen
authors.forename: M
authors.initials: M
authors.lastname: Grigoriadou
authors.forename: D
authors.initials: D
authors.lastname: Vassilopoulos
authors.forename: C
authors.initials: C
authors.lastname: Papageorgiou
authors.forename: K
authors.initials: K
authors.lastname: Psilas
authors.forename: M B
authors.initials: MB
authors.lastname: Petersen
mesh_terms: D000328:Adult; D017668:Age of Onset; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant / Q000235:genetics; D008040:Genetic Linkage; D005902:Glaucoma, Open-Angle / Q000235:genetics*; D006115:Greece; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D010375:Pedigree