title: The syndrome of painful legs and moving toes--a case report.
abstract: The syndrome of painful legs and moving toes is an uncommon and distressing condition with pain in the feet or legs and involuntary movements of the toes. It can follow spinal cord or cauda equina trauma, lumbar radiculopathy, injury to the feet, peripheral neuropathy or without any preceding causes. Ephaptic transmission in damaged nerve roots or peripheral nerves with central reorganisation may be the underlying mechanism of the syndrome. Treatment is difficult. We report a case of this syndrome following peripheral neuropathy, with a good early response to the GABA agonists baclofen and clonazepam. The role of different GABA agonists in the treatment of this condition needs to be better defined.
authors.affiliation: Department of Neurology Tan Tock Seng Hospital, Singapore.
authors.forename: A K
authors.initials: AK
authors.lastname: Tan
authors.forename: C B
authors.initials: CB
authors.lastname: Tan
mesh_terms: D001418:Baclofen / Q000008:administration & dosage / Q000627:therapeutic use; D002998:Clonazepam / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D018755:GABA Agonists / Q000008:administration & dosage / Q000627:therapeutic use; D018757:GABA Modulators / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D009468:Neuromuscular Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D010148:Intractable Pain / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D012148:Restless Legs Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D013577:Syndrome; D014034:Toes / Q000294:innervation*
chemical_list: D018755:GABA Agonists; D018757:GABA Modulators; D002998:Clonazepam; D001418:Baclofen