title: High-performance liquid chromatography/NMR spectrometry/mass spectrometry: further advances in hyphenated technology.
abstract: The earlier use of combined liquid chromatography/NMR spectrometry/mass spectrometry (LC/NMR/MS) involved the use of a particle beam interface. This paper describes further developments of this hyphenated technology, in particular the incorporation of an electrospray interface into the LC/NMR/MS system. This improved LC/NMR/MS system was designed for the support of a combinatorial library program. The power of this technique is demonstrated in the successful structural elucidation of each compound in a mixture of commercially available peptides.
authors.affiliation: Pfizer Central Research, Sandwich, Kent, UK.
authors.forename: R M
authors.initials: RM
authors.lastname: Holt
authors.forename: M J
authors.initials: MJ
authors.lastname: Newman
authors.forename: F S
authors.initials: FS
authors.lastname: Pullen
authors.forename: D S
authors.initials: DS
authors.lastname: Richards
authors.forename: A G
authors.initials: AG
authors.lastname: Swanson
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D010455:Peptides / Q000032:analysis / Q000737:chemistry*; D013053:Spectrophotometry
chemical_list: D010455:Peptides