title: Camptothecin resistance related to drug-induced down-regulation of topoisomerase I and to steps occurring after the formation of protein-linked DNA breaks.
authors.affiliation: Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Murren
authors.forename: D R
authors.initials: DR
authors.lastname: Beidler
authors.forename: Y C
authors.initials: YC
authors.lastname: Cheng
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002166:Camptothecin / Q000494:pharmacology*; D018736:DNA Adducts; D004249:DNA Damage; D004264:DNA Topoisomerases, Type I / Q000378:metabolism*; D015536:Down-Regulation; D004351:Drug Resistance; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D059004:Topoisomerase I Inhibitors
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D018736:DNA Adducts; D004791:Enzyme Inhibitors; D059004:Topoisomerase I Inhibitors; D004264:DNA Topoisomerases, Type I; D002166:Camptothecin