Antimutagenic effect of methanolic extracts from peanut hulls.
The antimutagenic effects of methanolic extracts of peanut hulls (MEPH) were evaluated by the Ames test. MEPH inhibited the mutagenicity of 4-nitroquinoline-N-oxide (NQNO), a direct-acting mutagen. MEPH also inhibited the mutagenicity of some indirect-acting mutagens and decreased in the order of 2-amino-3-methyl-imidazo(4,5-f)quinoline (IQ) > aflatoxin B1 (AFB1) > 2-amino-6-methyldipyrido(1,2-a:3',2'-d)imidazole (Glu-P-1) > 3 amino-1,4-dimethyl-5H-pyridol(4,3-b)indole (Trp-P-1) > benzo(a)pyrene (B(a)P for S. typhimurium TA98, and IQ > Trp-P-1 > Glu-P-1 > AFB1 > B(a)P for S. typhimurium TA100.
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Department of Food Science, National Chung Hsing University, Taiwan, Republic of China.
Duh
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D015112:4-Nitroquinoline-1-oxide / Q000633:toxicity; D016604:Aflatoxin B1 / Q000633:toxicity; D000818:Animals; D016587:Antimutagenic Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D010367:Arachis / Q000737:chemistry*; D001564:Benzo(a)pyrene / Q000633:toxicity; D002243:Carbolines / Q000633:toxicity; D007093:Imidazoles / Q000633:toxicity; D008297:Male; D000432:Methanol; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D011804:Quinolines / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D012486:Salmonella typhimurium / Q000235:genetics
D016587:Antimutagenic Agents; D002243:Carbolines; D007093:Imidazoles; D009153:Mutagens; D010936:Plant Extracts; D011804:Quinolines; C029216:2-amino-3-methylimidazo(4,5-f)quinoline; D001564:Benzo(a)pyrene; D015112:4-Nitroquinoline-1-oxide; C023785:2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole; D016604:Aflatoxin B1; C019132:3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole; D000432:Methanol