Serum soluble IL-2 receptor as a reliable and noninvasive marker of disease activity in patients with hairy cell leukemia.
Hairy cell leukemia is a chronic lymphoproliferative disorder of B-cell lineage. Malignant cells express the interleukin-2 receptor (IL-2R) which is released in vitro as well as in vivo. The sera of patients with hairy cell leukemia contain elevated levels of this soluble receptor (sIL-2R). Sera of 24 patients with hairy cell leukemia were tested for sIL-2R. In 9 patients treated with 2-chlorodeoxyadenosine an improved clinical status was associated with decreasing serum sIL-2R. The maximal rate of decrease of sIL-2R level was observed within the second and the third week after the therapy initiation. Patients with disease progression had an increase in serum sIL-2R level. Our results suggest that serial measurement of sIL-2R level can be used as a reliable, noninvasive means to assess the disease activity and its response to therapy.
Chrobák
L
L
Department of Clinical Hematology, University Hospital, Charles University, Faculty of Medicine, Hradec Králové, Czech Republic.
Podzimek
K
K
Plísková
L
L
Kerekes
Z
Z
Zák
P
P
Voglová
J
J
Spacek
J
J
Palicka
V
V
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood*; D017338:Cladribine / Q000627:therapeutic use; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000097:blood* / Q000187:drug effects
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D015375:Receptors, Interleukin-2; D017338:Cladribine