title: Oestradiol-induced taste avoidance is the result of a conditioned palatability shift.
abstract: Taste avoidances were conditioned in male rats by pairing ingestion of a novel sucrose (0.3 M solution) taste with injections of 17 beta oestradiol (100 micrograms kg-1, s.c.). Following conditioning and prior to a two-bottle choice test (sucrose vs water), taste reactivity responses to three 30 s intraoral sucrose infusions were quantified. A robust conditioned shift in palatability, consisting of reduced ingestive and increased aversive taste reactivity responses, was obtained in the oestradiol group but not the vehicle control group. This conditioned palatability shift was also reflected in subsequent strong avoidance of the sucrose solution in the two-bottle choice test. The findings that oestradiol can condition taste aversions and shift food preferences support a role for oestrogens in the production of anorexia.
authors.affiliation: Neuroscience Program, University of Western Ontario, London, Canada.
authors.forename: K P
authors.initials: KP
authors.lastname: Ossenkopp
authors.forename: Y J
authors.initials: YJ
authors.lastname: Rabi
authors.forename: L A
authors.initials: LA
authors.lastname: Eckel
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013649:Taste / Q000187:drug effects*
chemical_list: D004958:Estradiol