[The prediction of the probability of the development of myocardial infarct by genetic and phenotypic markers].
The study was made of marker distribution of 17 hereditary polymorphism systems in 493 patients with myocardial infarction (MI) and 422 healthy subjects. The prognostic system for determination of predisposition or resistance to MI development has been designed in accordance with marker occurrence in the patients and healthy subjects basing on Bayer's method. When the sum of the prognostic ratios of all the markers is +5 scores and more there is a high risk of MI, when this sum is -6 scores and less the resistance to its genesis is predicted. The proposed prognostic system makes it possible to predict predisposition to myocardial infarction at an early age and, therefore, to take preventive measures.
Gorbatovskiĭ
Ia A
IaA
Filimonov
S N
SN
Lomosh
E A
EA
Luzina
E A
EA
Levchenko
V G
VG
Mikhaĭlovichev
O Iu
OIu
D000328:Adult; D001789:Blood Group Antigens / Q000235:genetics; D016009:Chi-Square Distribution; D004198:Disease Susceptibility; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D010641:Phenotype; D011336:Probability; D011379:Prognosis; D012307:Risk Factors
D001789:Blood Group Antigens; D005819:Genetic Markers