Pseudo-Gaucher's cells in association with common acute lymphoblastic leukemia.
Gaucher-like cells were found in the bone marrow and liver of an Omani teenager who had common acute lymphoblastic leukemia (cALL) confirmed on peripheral blood analysis by the presence of CD10 antigen. Leukocytic or fibroblastic beta-glucocerebrosidase enzyme activity was not measured, but other biochemical data and features of bone marrow on electron microscopy were not indicative of genuine type 1 Gaucher's disease. To our knowledge, this is the first report of pseudo-Gaucher's cells in association with cALL.
Knox-Macaulay
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Department of Hematology, College of Medicine, Sultan Qaboos University, Muscat, Sultanate of Oman.
Bhusnurmath
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Alwaily
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A
D000293:Adolescent; D001853:Bone Marrow / Q000648:ultrastructure*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005776:Gaucher Disease / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008297:Male; D015260:Neprilysin / Q000032:analysis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology*
D015260:Neprilysin