Physiologic characterization of novel aggressotropic neuropeptides.
Experimental data of physiological activity of synthetic analogs of three novel neuropeptides isolated from the bovine brain are presented. The characteristics of the influence of the peptides on various forms of aggressivity of rats--intermale, predatory, and defense--with central and peripheral administration, are demonstrated. The influence of the peptides on other types of behavior--the consumption of food and water, fear, locomotor activity--associated with the formation of aggression is demonstrated. The modulatory effects of the peptides on the responses of identified neurons of molluscs to neuromediators, serotonin, dopamine, and glutamate, which participate in the neurochemical support of aggressive behavior of rats, are documented.
Sherstnev
V V
VV
P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow.
Galeva
N N
NN
Kozyrev
S A
SA
Nikitin
V P
VP
Pletnikov
M V
MV
Sudakov
K V
KV
Storozheva
Z I
ZI
D000374:Aggression / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001923:Brain Chemistry; D002417:Cattle; D002462:Cell Membrane / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D017952:Ganglia, Invertebrate / Q000187:drug effects; D066298:In Vitro Techniques; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009474:Neurons / Q000187:drug effects; D009479:Neuropeptides / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000502:physiology; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D012908:Snails; D013045:Species Specificity
D009479:Neuropeptides