title: Repeated isolation in the neonatal rat produces alterations in behavior and ventral striatal dopamine release in the juvenile after amphetamine challenge.
abstract: Rat pups were isolated from the mother and nest for 1 hr per day from Postnatal Day (PN) 2 to 9 At PN 27, rats were tested for behavioral responsiveness to 2.0 or 7.5 mg/kg amphetamine. Only isolated rats receiving the 7.5 mg/kg dose displayed increased activity scores, compared with nonisolated and nonhandled controls. Their increased activity is attributed to a slower latency to enter into stereotypy. In a second experiment, similarly treated groups were challenged by the 7.5 mg/kg dose during a session in which a microdialysis probe implanted in the ventral striatum was being perfused. The challenge drug elicited a much greater increase in dialysate dopamine in isolated vs. nonisolated groups. Results are discussed with regard to dissociation between sensitized and subsensitized responses.
authors.affiliation: Department of Psychology, Trinity College, Hartford, Connecticut 06106, USA. priscilla.kehoe@mail.trincoll.edu
authors.forename: P
authors.initials: P
authors.lastname: Kehoe
authors.forename: W J
authors.initials: WJ
authors.lastname: Shoemaker
authors.forename: L
authors.initials: L
authors.lastname: Triano
authors.forename: J
authors.initials: J
authors.lastname: Hoffman
authors.forename: C
authors.initials: C
authors.lastname: Arons
mesh_terms: D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology*; D003342:Corpus Striatum / Q000737:chemistry* / Q000187:drug effects* / Q000502:physiology; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012934:Social Isolation; D013239:Stereotyped Behavior / Q000187:drug effects; D013997:Time Factors
chemical_list: D000661:Amphetamine; D004298:Dopamine