title: Central nervous system involvement at diagnosis in a case of pediatric CD30+ anaplastic large cell lymphoma.
abstract: Central nervous system (CNS) involvement in Ki-1/CD30 lymphoma is extremely rare, in contrast to the frequent involvement in other types of pediatric non-Hodgkin's lymphoma. No mechanism has yet been proposed to explain the sparing of the blood brain barrier in Ki-1/lymphoma. We present a 2-year-old boy who was admitted to the Department of Pediatric Hemato-Oncology due to lethargy, progressive breathing difficulties, massive diffuse lymphadenopathy, hepatosplenomegaly, and ichthyosis-like skin involvement with epidermolysis. A lymph node biopsy was compatible with Ki-1/CD30 anaplastic large cell lymphoma (ALCL). Bone marrow aspirate and biopsy demonstrated reactive hyperplasia. Cytogenetic analysis displayed hyperdiploid cells with 1p(-) in most cells. Cerebrospinal fluid examination showed pleocytosis with CD30+ cells. Possible mechanisms which could enable CNS involvement in this unusual case are discussed.
authors.affiliation: Department of Pediatric Hemato-Oncology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: C
authors.initials: C
authors.lastname: Kaplinsky
authors.forename: A
authors.initials: A
authors.lastname: Toren
authors.forename: Y
authors.initials: Y
authors.lastname: Neumann
authors.forename: M
authors.initials: M
authors.lastname: Mandel
authors.forename: G
authors.initials: G
authors.lastname: Kenet
authors.forename: N
authors.initials: N
authors.lastname: Sharon
authors.forename: G
authors.initials: G
authors.lastname: Rechavi
authors.forename: M
authors.initials: M
authors.lastname: Biniaminov
authors.forename: V
authors.initials: V
authors.lastname: Rubanov
authors.forename: E
authors.initials: E
authors.lastname: Rosenthal
authors.forename: E
authors.initials: E
authors.lastname: Rosner
authors.forename: Z
authors.initials: Z
authors.lastname: Mark
authors.forename: N
authors.initials: N
authors.lastname: Amariglio
authors.forename: F
authors.initials: F
authors.lastname: Brok-Simoni
mesh_terms: D016543:Central Nervous System Neoplasms / Q000175:diagnosis / Q000473:pathology*; D002675:Child, Preschool; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis / Q000473:pathology*; D008297:Male
chemical_list: D017730:Ki-1 Antigen