The interdependence of lung antioxidants and antiprotease defense in ARDS.
As in hereditary alpha 1-antitrypsin deficiency, protease-antiprotease and oxidant-antioxidant balances play a significant role in the pathogenesis of ARDS. However, the disease processes and possibilities for therapeutic intervention differ markedly.
Gadek
J E
JE
Department of Internal Medicine, Ohio State University, Columbus, USA.
Pacht
E R
ER
D000975:Antioxidants / Q000378:metabolism*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D019272:Leukocyte Elastase / Q000378:metabolism; D015227:Lipid Peroxidation; D008168:Lung / Q000201:enzymology / Q000378:metabolism*; D011480:Protease Inhibitors / Q000378:metabolism*; D012128:Respiratory Distress Syndrome / Q000378:metabolism / Q000503:physiopathology*
D000975:Antioxidants; D011480:Protease Inhibitors; D019272:Leukocyte Elastase