title: The contralateral cortex contributes to the effects of hemidecortication on neuropeptide Y immunoreactivity in the rat striatum.
abstract: We have previously shown that unilateral lesion by thermocoagulation of sensori-motor cortex which provides excitatory afferents to the striatum increases the number of neuropeptide Y (NPY)-immunoreactive neurons in the rat striatum. The present study examined whether this paradoxical effect is due to adaptive neuronal mechanisms involving the crossed projections from the contralateral spared cortex. To test this hypothesis, we compared the effects of unilateral and bilateral cortical lesions on the number of NPY-immunoreactive neurons in the striatum. Results showed that animals with bilateral lesion have no significant change in NPY immunoreactivity versus control suggesting that the contralateral intact cortex is responsible for the increase of NPY-immunoreactive neurons detected after unilateral lesion.
authors.affiliation: Laboratoire de Neurobiologie Cellulaire et Fonctionnelle, UPR 9013, CNRS, Marseille, France.
authors.forename: P
authors.initials: P
authors.lastname: Salin
authors.forename: A
authors.initials: A
authors.lastname: Nieoullon
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D003655:Decerebrate State / Q000378:metabolism*; D004745:Enkephalins / Q000096:biosynthesis; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D007150:Immunohistochemistry; D017072:Neostriatum / Q000378:metabolism*; D009473:Neuronal Plasticity / Q000502:physiology; D009478:Neuropeptide Y / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004745:Enkephalins; D009478:Neuropeptide Y; D012333:RNA, Messenger