title: Amarogentin, a naturally occurring secoiridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani.
abstract: A MeOH extract of Swertia chirata found to inhibit the catalytic activity of topoisomerase I of Leishmania donovani was subjected to fractionation to yield three secoiridoid glycosides: amarogentin (1), amaroswerin (2), and sweroside (3). Amarogentin is a potent inhibitor of type I DNA topoisomerase from Leishmania and exerts its effect by interaction with the enzyme, preventing binary complex formation.
authors.affiliation: Indian Institute of Chemical Biology, Calcutta, India.
authors.forename: S
authors.initials: S
authors.lastname: Ray
authors.forename: H K
authors.initials: HK
authors.lastname: Majumder
authors.forename: A K
authors.initials: AK
authors.lastname: Chakravarty
authors.forename: S
authors.initials: S
authors.lastname: Mukhopadhyay
authors.forename: R R
authors.initials: RR
authors.lastname: Gil
authors.forename: G A
authors.initials: GA
authors.lastname: Cordell
mesh_terms: D000818:Animals; D016054:DNA, Protozoan / Q000737:chemistry / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007194:India; D039823:Iridoids; D007893:Leishmania donovani / Q000201:enzymology*; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D059004:Topoisomerase I Inhibitors
chemical_list: D016054:DNA, Protozoan; D004791:Enzyme Inhibitors; D005960:Glucosides; D039823:Iridoids; D011714:Pyrans; D059004:Topoisomerase I Inhibitors; C102609:amarogentin