title: Pharmacokinetics of a new nitroderivative of acetylsalicylic acid after a single dose in rats.
abstract: The pharmacokinetics of a new ASA-nitroderivative compound, NCX 4016 (ASA-NO2), was evaluated using an HPLC method. After single equimolar doses of ASA (35 mg kg(-1)) or ASA-NO2 (65 mg kg(-1)), no detectable levels of these compounds have been observed in rat plasma samples. SA peak levels were obtained at 3 h and 6 h after ASA and ASA-NO2 administration respectively. The elimination rate constants of SA were similar after ASA and ASA-NO2, suggesting a similar elimination phase of this metabolite in rats. From these data it is evident that ASA-NO2 is slowly metabolized in ASA, which is rapidly converted to SA.
authors.affiliation: Institutes of Pharmacology and Forensic Medicine, University of Verona, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Tagliaro
authors.forename: L
authors.initials: L
authors.lastname: Cuzzolin
authors.forename: A
authors.initials: A
authors.lastname: Adami
authors.forename: D
authors.initials: D
authors.lastname: Scarcella
authors.forename: F
authors.initials: F
authors.lastname: Crivellente
authors.forename: G
authors.initials: G
authors.lastname: Benoni
mesh_terms: D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001241:Aspirin