Pathogenic in vitro studies of pemphigus vulgaris. I. Experimental model of pemphigus vulgaris in cultures in diffusion chambers.
Normal human skin, cultivated in diffusion chambers with biological membranes in the presence of serum from pemphigus vulgaris patient in the culture, developed all microscopic signs of an acantholytic process. An experimental model of pemphigus was thus created for the first time in our country and proposed by the authors as suitable basis for further studies on the disease pathogenesis and treatment.
Popova
L
L
Department of Histology and Embryology, Medical University, Plovdiv, Bulgaria.
Dobrev
H
H
Vlashev
D
D
D046508:Culture Techniques; D006801:Humans; D010392:Pemphigus; D012867:Skin / Q000473:pathology*