Lowered phosphorylation of topoisomerase I is a direct reason for reduced sensitivity of L5178Y-S cells to camptothecin.
Staron
K
K
Institute of Biochemistry, Warsaw University, Poland.
Kowalska-Loth
B
B
Szumiel
I
I
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002166:Camptothecin / Q000494:pharmacology*; D004264:DNA Topoisomerases, Type I / Q000378:metabolism*; D004351:Drug Resistance; D007940:Leukemia L5178 / Q000201:enzymology* / Q000473:pathology; D051379:Mice; D010766:Phosphorylation; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D011064:Poly Adenosine Diphosphate Ribose; D004264:DNA Topoisomerases, Type I; D002166:Camptothecin