Antiplatelet arylnaphthalide lignans from Justicia procumbens.
Fractionation of the EtOH extract of Justicia procumbens, guided by antiplatelet bioassay, led to the isolation of nine known arylnaphthalide lignans, neojusticin A (1), justicidin B (2), justicidin A (3), taiwanin E methyl ether (4), neojusticin B (5), chinensinaphthol methyl ether (6), taiwanin E (8), chinensinaphthol (9), and diphyllin (10), and a new arylnaphthalide lignan that was characterized by spectral means as 4'-demethylchinensinaphthol methyl ether (7). Compounds 1, 2, 4, and 8 significantly inhibited platelet aggregation.
Chen
C C
CC
National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China.
Hsin
W C
WC
Ko
F N
FN
Huang
Y L
YL
Ou
J C
JC
Teng
C M
CM
D000818:Animals; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009281:Naphthalenes / Q000302:isolation & purification* / Q000494:pharmacology; D009391:Nephelometry and Turbidimetry; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D011817:Rabbits; D013055:Spectrophotometry, Infrared
D009281:Naphthalenes; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors