1-Methyl-1H-2-imidazo[4,5-b]pyridinecarboxylic acid and some of its derivatives with suspected antituberculotic activity.
2-Hydroxymethyl-1-methyl-1H-imidazo[4,5-b]pyridine was obtained and its oxidation was carried out. 1-Methyl-1H-2-imidazo[4,5-b]pyridinecarboxylic acid, its methyl ester, amide, nitrile, thioamide, amidoxime, hydrazide and hydrazidehydrazones were synthesized. Willgerodt-Kindler reaction of 1,2-dimethyl-1H-imidazo[4,5-b]pyridine was investigated. Some of the obtained compounds were tested for antituberculotic activity.
Bukowski
L
L
Department of Organic Chemistry, Medical University of Gdańsk, Warsaw, Poland.
Janowiec
M
M
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004352:Drug Resistance, Microbial; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010084:Oxidation-Reduction; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000382:microbiology
D000995:Antitubercular Agents; D007093:Imidazoles; D011725:Pyridines