title: [Influence of physiological and pharmacological amounts of iodine on the 131I uptake of the thyroid gland--a model calculation].
abstract: OBJECTIVE
  The aim of this paper was to use a iodine metabolism model in order to analyze theoretically the different aspects of the iodine metabolism.
  
  
  METHODS
  To perform this a three compartment model was developed.
  
  
  RESULTS
  With this model we examined the influence of physiological and pharmacological iodine amounts on the iodine-131 uptake in the thyroid gland and additionally the excretion of Iodine-131 after radiotherapy. It can be said, that an in-patient admission for a duration of at least three days to perform a radiotherapy is sensible (wise) and a iodine-poor diet prior to the radiotherapy is of advantage. Regarding the iodine blockade of the thyroid gland after a reactor accident the effects (outcome) of the German recommendations were compared with the WHO-guidelines.
  
  
  CONCLUSIONS
  The model of iodine metabolism is suited for analyses even if because of ethic or other limitations measurements at human beings are not possible.
authors.affiliation: Klinik und Poliklinik für Nuklearmedizin, Universität zu Köln, Deutschland.
authors.forename: U
authors.initials: U
authors.lastname: Wellner
authors.forename: K
authors.initials: K
authors.lastname: Alef
authors.forename: H
authors.initials: H
authors.lastname: Schicha
mesh_terms: D005858:Germany; D017408:Guidelines as Topic; D006801:Humans; D007455:Iodine / Q000378:metabolism*; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D011877:Radionuclide Imaging; D011878:Radiotherapy / Q000379:methods* / Q000592:standards; D013961:Thyroid Gland / Q000000981:diagnostic imaging* / Q000378:metabolism*; D014018:Tissue Distribution; D014944:World Health Organization
chemical_list: D007457:Iodine Radioisotopes; D007455:Iodine