title: Anterior segment prosthesis development: retinal function following anterior segment removal.
abstract: Replacement of the entire anterior segment of the eye is a very ambitious and complex endeavor and it is not known whether the retina remains functional when the anterior structures have been removed. We used routine histo-pathologic evaluation and electroretinographic measurements to determine the structural and functional status of rabbit retinas following surgical removal of the internal anterior structures (iris, ciliary body, and lens) and replacement of the vitreous with silicone oil. In some cases, we were able to record both a scotopic and a photopic electroretinographic response as long as 15 weeks after complete removal of the internal anterior segment structures. Although many hurdles remain and more efficacious surgical techniques and biomaterials need to be developed, our results suggest that, in the rabbit, the retina may continue to function in the absence of critical anterior segment structures.
authors.affiliation: Doheny Eye Institute, University of Southern California School of Medicine, Los Angeles 90033, USA.
authors.forename: A
authors.initials: A
authors.lastname: Guo
authors.forename: L W
authors.initials: LW
authors.lastname: Lee
authors.forename: L L
authors.initials: LL
authors.lastname: Rife
authors.forename: S
authors.initials: S
authors.lastname: Kwitko
authors.forename: N A
authors.initials: NA
authors.lastname: Rao
authors.forename: L P
authors.initials: LP
authors.lastname: Chong
authors.forename: T E
authors.initials: TE
authors.lastname: Ogden
authors.forename: R E
authors.initials: RE
authors.lastname: Smith
mesh_terms: D000818:Animals; D000869:Anterior Eye Segment / Q000601:surgery*; D004596:Electroretinography; D005500:Follow-Up Studies; D011183:Postoperative Complications; D019736:Prostheses and Implants; D011817:Rabbits; D012160:Retina / Q000473:pathology / Q000502:physiology*; D012827:Silicone Oils
chemical_list: D012827:Silicone Oils