title: Subacute uremic and diabetic polyneuropathy.
abstract: We present 4 patients who had a subacute, predominantly motor polyneuropathy associated with diabetes mellitus and end-stage renal disease. Electrophysiological studies and muscle biopsy indicated a primary axonal degeneration of nerve with secondary segmental demyelination, and mild to moderate, acute and chronic denervation of muscle. A relative absence of denervation potentials on needle electromyography was an unusual feature. Three of our patients improved with a switch from conventional to high-flux hemodialysis. We speculate on possible mechanisms.
authors.affiliation: Department of Clinical Neurological Sciences, Victoria Hospital, London, Ontario, Canada.
authors.forename: C F
authors.initials: CF
authors.lastname: Bolton
authors.forename: M J
authors.initials: MJ
authors.lastname: McKeown
authors.forename: R
authors.initials: R
authors.lastname: Chen
authors.forename: B
authors.initials: B
authors.lastname: Toth
authors.forename: H
authors.initials: H
authors.lastname: Remtulla
mesh_terms: D000368:Aged; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000502:physiology; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology; D014511:Uremia / Q000503:physiopathology*