title: Progression from adenocarcinoma to small cell carcinoma of the prostate with normalization of prostate-specific antigen (PSA) levels.
abstract: We report a case of prostatic cancer in which transformation from adenocarcinoma into small cell carcinoma was demonstrated both by histology and immunohistochemistry. This phenomenon supports the hypothesis that small cell carcinoma of the prostate originates from multipotential prostatic epithelial cells.
authors.affiliation: Department of Pathology, University of Helsinki, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Valle
authors.forename: K
authors.initials: K
authors.lastname: von Boguslawsky
authors.forename: M
authors.initials: M
authors.lastname: Stenborg
authors.forename: L C
authors.initials: LC
authors.lastname: Andersson
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D001707:Biopsy, Needle; D018288:Carcinoma, Small Cell / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D003131:Combined Modality Therapy; D004848:Epithelium / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy
chemical_list: D017430:Prostate-Specific Antigen