title: MRI versus CT in the diagnosis of Nelson's syndrome.
abstract: The purpose of the study was to evaluate the utility of MRI and CT in the diagnosis of Nelson's syndrome, i. e. pituitary tumours in patients bilaterally adrenalectomized for Cushing's disease. Thirteen patients, followed up for 5-29 years after adrenalectomy, were studied. In 6 of them CT and MRI revealed no changes in the pituitary gland. In the remaining 7 patients only three CT scans were suggestive of a pituitary adenoma. MRI studies with administration of gadodiamide confirmed the CT diagnosis of Nelson's tumour in 3 patients and disclosed microadenomas in a further 4 patients. Neurosurgical treatment in 4 patients confirmed the MRI findings. Additionally CT and MRI examinations were performed in 5 patients suspected of a recurrent Nelson's tumour 3-11 years after neurosurgery. MRI visualized recurrent adenomas in 3 patients that were not well seen by CT scans. In our experience MRI was more effective than CT in the diagnosis of Nelson's syndrome.
authors.affiliation: Department of Endocrinology, Centre of Postgraduate Medical Education, Ceglowska 80, 01-809 Warsaw, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Kasperlik-Zaluska
authors.forename: J
authors.initials: J
authors.lastname: Walecki
authors.forename: J
authors.initials: J
authors.lastname: Brzeziński
authors.forename: W
authors.initials: W
authors.lastname: Jeske
authors.forename: B
authors.initials: B
authors.lastname: Migdalska
authors.forename: W
authors.initials: W
authors.lastname: Bonicki
authors.forename: A
authors.initials: A
authors.lastname: Brzezińska
authors.forename: A
authors.initials: A
authors.lastname: Makowska
mesh_terms: D000315:Adrenalectomy / Q000009:adverse effects; D000328:Adult; D000368:Aged; D003480:Cushing Syndrome / Q000150:complications / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009347:Nelson Syndrome / Q000175:diagnosis* / Q000209:etiology; D010902:Pituitary Gland / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed