Synthesis and tumor inhibiting activity of lanthanum (III) complexes with some 1-aminocycloalkancarboxylic acids.
Complexes of La(III) with 1-aminocyclopentane-, -hexane, -heptane and -4-ethylcyclohexanecarboxylic acids were obtained. The compounds were characterized by elemental analyses, IR spectroscopy and conductivity measurements. The following general formula was derived: LaL3Cl3 x 5 H2O, where L is the corresponding 1-aminocycloalkanecarboxylic acid. The pharmacological studies showed that all complexes manifested higher cytostatic and cytotoxic effects in comparison with lanthanum chloride. Much higher cytotoxic (anti-P388/D1) and cytostatic (anti-L-1210 and anti-melanoma-B16) activity was found for the lanthanum complex with 1-aminocyclopentanecarboxylic acid.
Kovachev
T B
TB
Department of Chemistry, Higher Medical School, Sofia, Bulgaria.
Ivanov
D S
DS
Buyukliev
R T
RT
Konstantinov
S M
SM
Karaivanova
M C
MC
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007811:Lanthanum / Q000494:pharmacology; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D008024:Ligands; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D008024:Ligands; D009942:Organometallic Compounds; D007811:Lanthanum