title: In vitro & in vivo experimental susceptibility of Mycobacterium marinum to augmentin.
abstract: The effect of augmentin alone and in combination with various beta-lactam antibiotics was studied against a pathogenic Mycobacterium, M. marinum. The in vitro studies did not reveal any additional advantage over that found with augmentin alone and this antibiotic seemed considerably inhibitory to M. marinum at < 1 microgram/ml concentration. In vivo, the effects of augmentin on experimentally produced lesions in the mouse foot pads (MFPs) showed a significant regression of the lesions, which was compatible with an early disappearance of M. marinum from the MFP, in contrast with those of the untreated, control animals.
authors.affiliation: Department of Medical Microbiology & Parasitology, Calcutta University College of Medicine, Jadavpur University.
authors.forename: A
authors.initials: A
authors.lastname: Chakrabarti
authors.forename: C P
authors.initials: CP
authors.lastname: Bhattacharya
authors.forename: D P
authors.initials: DP
authors.lastname: Acharya
authors.forename: A N
authors.initials: AN
authors.lastname: Chakrabarty
authors.forename: K
authors.initials: K
authors.lastname: Ghosh
authors.forename: S G
authors.initials: SG
authors.lastname: Dastidar
mesh_terms: D000658:Amoxicillin / Q000494:pharmacology; D019980:Amoxicillin-Potassium Clavulanate Combination; D000818:Animals; D002969:Clavulanic Acids / Q000494:pharmacology; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests / Q000379:methods*; D009161:Mycobacterium / Q000187:drug effects*
chemical_list: D002969:Clavulanic Acids; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin