title: [Clinico-pharmacologic aspects of the use of ofloxacin].
abstract: Ofloxacin was used in the treatment of 124 patients with bronchopulmonary diseases, the diseases of the biliary system and other infectious inflammatory diseases of the internal organs. The microbiological and pharmacokinetic indices as well as the immune status were investigated. The drug proved to be efficient in the treatment of 78.9 per cent of the cases. The pharmacokinetic indices were evident of the fact that the treatment of severe cases should be started with the drug intravenous administration. Ofloxacin had no negative effects on the immune status.
authors.forename: V G
authors.initials: VG
authors.lastname: Kukes
authors.forename: R A
authors.initials: RA
authors.lastname: Belitskaia
authors.forename: M N
authors.initials: MN
authors.lastname: Dubova
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Krasavina
authors.forename: T A
authors.initials: TA
authors.lastname: Posrednikova
mesh_terms: D000890:Anti-Infective Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000917:Antibody Formation / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy* / Q000276:immunology; D001660:Biliary Tract Diseases / Q000188:drug therapy / Q000276:immunology; D001982:Bronchial Diseases / Q000188:drug therapy / Q000276:immunology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007136:Immunoglobulins / Q000097:blood; D007249:Inflammation / Q000188:drug therapy* / Q000276:immunology; D008171:Lung Diseases / Q000188:drug therapy / Q000276:immunology; D008297:Male; D015242:Ofloxacin / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents; D007136:Immunoglobulins; D015242:Ofloxacin