[The expression of nuclear proliferation antigen in oropharyngeal carcinoma].
Proliferating cell nuclear antigen (PCNA) is a nuclear protein synthesized in the late G1 and S phase of the cell cycle. Immunohistochemical detection of the protein is a useful marker of the proliferating cell fraction in tissue specimens. A series of 106 oropharyngeal carcinomas were evaluated using the streptavidin biotin immunoperoxidase method for detection of this protein. PCNA positivity ranged from 9 to 90.2% (mean: 54.86%; SD: 22.05). PCNA results did not correlate with clinical or histological parameters. Cox regression analysis confirmed the absence of statistical significance of the PCNA index in relation to overall survival.
Caminero Cueva
M J
MJ
Servicio de ORL, Hospital Central de Asturias, Oviedo.
Núñez Batalla
F
F
Suárez Nieto
C
C
Ablanedo Ablanedo
P
P
D002277:Carcinoma / Q000235:genetics* / Q000401:mortality; D018929:Cell Culture Techniques; D002453:Cell Cycle; D046508:Culture Techniques; D006801:Humans; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000235:genetics* / Q000401:mortality; D018809:Proliferating Cell Nuclear Antigen / Q000235:genetics*; D012333:RNA, Messenger; D015996:Survival Rate
D018809:Proliferating Cell Nuclear Antigen; D012333:RNA, Messenger