title: Meleda disease: report of two cases investigated by electron microscopy.
abstract: We report 2 cases of clinically typical Meleda disease in a family from Herzegovina. Electron microscopy did not reveal major ultrastructural anomalies of keratinization; however, the transition from stratum granulosum to stratum corneum appeared to occur less abruptly than normally by a stepwise process suggesting a slowing down of terminal cornification.
authors.affiliation: University Department of Dermatology, Lausanne, Switzerland.
authors.forename: E
authors.initials: E
authors.lastname: Frenk
authors.forename: D
authors.initials: D
authors.lastname: Guggisberg
authors.forename: B
authors.initials: B
authors.lastname: Mevorah
authors.forename: D
authors.initials: D
authors.lastname: Hohl
mesh_terms: D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D005190:Family; D005260:Female; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron