Retroviral coinfections at a New Orleans HIV outpatient clinic.
The purpose of the study was to determine the seroprevalence of human T-lymphotropic virus types I and II (HTLV-I and HTLV-II) infections in an outpatient clinic population of human immunodeficiency virus (HIV)-1 infected persons as well as to identify the demographic and clinical characteristics and laboratory results associated with HTLV-I/II infections. During 1993-1995, 854 patients were tested for HTLV-I/II infection on entry into the clinic, of whom 25 were infected with HTLV-I and 35 with HTLV-II. Multivariate analysis revealed that patients with coinfections were more likely to be black, aged over 35 years, and have a history of injection drug use. HIV-1/HTLV-I coinfections were associated with higher median CD8 counts on entry (p < 0.05), and HIV-1/HTLV-II coinfections were associated with higher median percent CD4 counts (p < 0.05) compared with patients infected with HIV only. Coinfection was not associated with an increased diagnosis of AIDS. These findings indicate that HIV-1/HTLV-I/II coinfections are frequently diagnosed and are associated with unique immune phenotypes. Given the lack of information regarding the influence of dual infection on clinical status, differentiation of HTLV-I from HTLV-II infections may be important in understanding the clinical significance of retroviral coinfections.
Bessinger
R
R
HIV Outpatient Program, Louisiana State University Medical Center, New Orleans 70112, USA.
Beilke
M
M
Kissinger
P
P
Jarrott
C
C
Tabak
O F
OF
D000328:Adult; D016516:CD4-CD8 Ratio; D005260:Female; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1; D015481:HTLV-I Antibodies / Q000097:blood; D015490:HTLV-I Infections / Q000150:complications / Q000453:epidemiology*; D015482:HTLV-II Antibodies / Q000097:blood; D015491:HTLV-II Infections / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008145:Louisiana / Q000453:epidemiology; D018655:Lymphocyte Count; D008297:Male; D016017:Odds Ratio; D010044:Outpatient Clinics, Hospital / Q000706:statistics & numerical data; D015995:Prevalence
D015481:HTLV-I Antibodies; D015482:HTLV-II Antibodies