title: The high mobility group I-C gene (HMGI-C): polymorphism and genetic localization.
abstract: We have identified a highly informative dinucleotide repeat in the 5'-flanking region of the human high mobility group I-C (HMGI-C) gene. This polymorphism consists of 18-37 copies of a (CT) repeat with an observed heterozygosity of 82-83% in African Americans and Caucasians. Linkage analysis in CEPH pedigrees localized the HMGI-C gene to chromosome region 12q13-15 with no recombination observed between HMCI-C and markers D12S102 and D12S8.
authors.affiliation: Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA.
authors.forename: C S
authors.initials: CS
authors.lastname: Ishwad
authors.forename: M D
authors.initials: MD
authors.lastname: Shriver
authors.forename: D M
authors.initials: DM
authors.lastname: Lassige
authors.forename: R E
authors.initials: RE
authors.lastname: Ferrell
mesh_terms: D001741:Black or African American; D044383:Black People / Q000235:genetics; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D017931:DNA Primers; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D025743:HMGA2 Protein; D006609:High Mobility Group Proteins / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D018895:Microsatellite Repeats; D009687:Nuclear Proteins / Q000235:genetics; D010375:Pedigree; D010414:Pennsylvania; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic; D044465:White People / Q000235:genetics
chemical_list: D017931:DNA Primers; D005819:Genetic Markers; D025743:HMGA2 Protein; D006609:High Mobility Group Proteins; D009687:Nuclear Proteins