Elevated in vivo expression of the costimulatory molecule B7-BB1 (CD80) on antigen presenting cells from a patient with SLE.
The CD28/CTLA4-B7-family plays an important role in T-cell costimulation and is crucial for IL-2 production and tolerance induction. The costimulatory molecule B7-BB1 (CD80) is expressed on activated antigen presenting cells, but its expression on peripheral blood mononuclear cells is very low. Here we report a patient with untreated SLE whose peripheral blood antigen presenting cells expressed increased amounts of B7-BB1.
Kovacs
B
B
Department of Clinical Physiology, Walter Reed Army Institute of Research, Washington, DC 20307-5001, USA.
Thomas
D E
DE
Tsokos
G C
GC
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000938:Antigen-Presenting Cells / Q000276:immunology*; D018122:B7-1 Antigen / Q000276:immunology*; D002648:Child; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007371:Interferon-gamma / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000276:immunology / Q000628:therapy; D011239:Prednisolone / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D018122:B7-1 Antigen; D007371:Interferon-gamma; D011239:Prednisolone