[The correlations of lipid peroxidation, antioxidant protection and microrheological disorders in the development of IHD].
Lipid peroxidation, antioxidant defense and microrheological properties of blood were determined, correlated and compared with clinico-hemodynamic indices in patients with ischemic heart disease (IHD). It is shown that products of lipid peroxidation modify structure and function of red cells and platelets in IHD. A regulatory role of the antioxidant system in metabolism of lipoperoxides and peroxide damage to blood cells in IHD is shown. A pathogenetic implication of correlated changes in the systems of lipid peroxidation and antioxidant defense, microrheological properties of blood in formation of clinical course of IHD is revealed.
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D000328:Adult; D000787:Angina Pectoris / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D000975:Antioxidants; D004907:Erythrocyte Deformability; D006334:Heart Function Tests / Q000706:statistics & numerical data; D006439:Hemodynamics; D018056:Hemorheology; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D005082:Physical Exertion
D000975:Antioxidants