A new quassinoid from Castela texana.
A new quassinoid, 11-O-trans-p-coumaroyl amarolide (1) was isolated from Castela texana, and the structure was elucidated by spectroscopic analysis. Compound 1 is the first coumaroyl quassinoid derivative to have been isolated from nature. The known compounds amarolide (2), chaparrinone, chaparrin, glaucarubolone, holacanthone, and 15-O-beta-D-glucopyranosyl glaucarubol were also isolated. All isolated compounds were tested for their cytotoxicity and antiprotozoal activities.
Dou
J
J
Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, University of Mississippi, University 38677, USA.
McChesney
J D
JD
Sindelar
R D
RD
Goins
D K
DK
Walker
L A
LA
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D005872:Giardia / Q000187:drug effects; D008800:Mexico; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D013781:Texas; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D014344:Trypanocidal Agents / Q000494:pharmacology; D014407:Tumor Cells, Cultured
C102615:11-O-4-coumaroyl amarolide; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D000981:Antiprotozoal Agents; D014315:Triterpenes; D014344:Trypanocidal Agents