Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS.
Subcutaneous injection of FK506 (10 mg/kg of body weight) completely blocked the clonal expansion of staphylococcal enterotoxin A (SEA)-reactive T cells in healthy (control) mice after SEA injection but did not disturb it in mice with murine AIDS (MAIDS) caused by infection with LP-BM5 murine leukemia virus. MAIDS mice are characterized by utilization of a FK506-insensitive pathway for clonal expansion of superantigen-reactive T cells.
Yoshikai
Y
Y
Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Japan. yyoshika@tsuru.med.nagoya-u.ac.jp
Kidokoro
H
H
Kimura
K
K
Aoki
Y
Y
Makino
M
M
Hiromatsu
K
K
D000818:Animals; D019703:Calcineurin; D002148:Calmodulin-Binding Proteins / Q000037:antagonists & inhibitors*; D002460:Cell Line; D016572:Cyclosporine / Q000494:pharmacology; D004768:Enterotoxins / Q000494:pharmacology*; D005260:Female; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007376:Interleukin-2 / Q000096:biosynthesis; D009052:Leukemia Virus, Murine / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D016183:Murine Acquired Immunodeficiency Syndrome / Q000276:immunology*; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors*; D018089:Superantigens / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D016559:Tacrolimus / Q000494:pharmacology*
D002148:Calmodulin-Binding Proteins; D004768:Enterotoxins; D007166:Immunosuppressive Agents; D007376:Interleukin-2; D018089:Superantigens; C026066:enterotoxin A, Staphylococcal; D016572:Cyclosporine; D019703:Calcineurin; D010749:Phosphoprotein Phosphatases; D016559:Tacrolimus