title: Drug sensitivity of human immunodeficiency virus type 1 isolates after ribavirin therapy.
abstract: The antiviral agent ribavirin is effective against several virally induced diseases, and there is evidence that it might prove useful against human immunodeficiency virus type 1 (HIV-1) infection. Thus, there is interest in studying the resistance level of HIV-1 isolates to ribavirin following drug therapy. Low-passage clinical strains of HIV-1 were isolated from 3 patients undergoing treatment with ribavirin for 5-9 months. No significant changes in drug sensitivity were seen for sequential virus samples obtained before, during, and after antiviral therapy. These observations suggest that the appearance of a resistant phenotype is not induced by treatment with ribavirin in HIV-1-infected persons.
authors.affiliation: Centre de Recherche en Infectiologie, Département de Microbiologie, Faculté de Médecine, Université Laval, Ste-Foy, Montreal, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Bernier
authors.forename: M
authors.initials: M
authors.lastname: Tremblay
authors.forename: C
authors.initials: C
authors.lastname: Tsoukas
authors.forename: M G
authors.initials: MG
authors.lastname: Bergeron
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004311:Double-Blind Method; D004352:Drug Resistance, Microbial; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012254:Ribavirin / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D012254:Ribavirin