Progression from adenocarcinoma to small cell carcinoma of the prostate with normalization of prostate-specific antigen (PSA) levels.
We report a case of prostatic cancer in which transformation from adenocarcinoma into small cell carcinoma was demonstrated both by histology and immunohistochemistry. This phenomenon supports the hypothesis that small cell carcinoma of the prostate originates from multipotential prostatic epithelial cells.
Valle
J
J
Department of Pathology, University of Helsinki, Finland.
von Boguslawsky
K
K
Stenborg
M
M
Andersson
L C
LC
D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D001707:Biopsy, Needle; D018288:Carcinoma, Small Cell / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D003131:Combined Modality Therapy; D004848:Epithelium / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy
D017430:Prostate-Specific Antigen