title: Structure-activity relationships of phomactin derivatives as platelet activating factor antagonists.
abstract: Phomactins, natural products isolated from the culture broth of marine fungus Phoma sp., were found to be active as PAF antagonists. This unique carbon skeleton led us to investigate the structure-activity relationship demonstrating that the lipophilicity at C-(7-8), acetoxy, (methoxycarbonyl)oxy, and 3-isoxazolyloxy substitution at C-20, and 2-beta-OH configuration at C-2 are all required for the enhancement of inhibitor activity.
authors.affiliation: Biomedical Research Laboratories, Sankyo Co. Ltd, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sugano
authors.forename: A
authors.initials: A
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Saito
authors.forename: S
authors.initials: S
authors.lastname: Takaishi
authors.forename: Y
authors.initials: Y
authors.lastname: Matsushita
authors.forename: Y
authors.initials: Y
authors.lastname: Iijima
mesh_terms: D004852:Epoxy Compounds / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D011869:Radioligand Assay; D013329:Structure-Activity Relationship
chemical_list: D004852:Epoxy Compounds; D010972:Platelet Activating Factor; C103093:phomactin D