title: Lower levels of nucleoside triphosphate in the basal ganglia of depressed subjects: a phosphorous-31 magnetic resonance spectroscopy study.
abstract: OBJECTIVE
  The purpose of this study was to evaluate whether the concentration of beta-nucleoside triphosphate is lower in the basal ganglia of depressed subjects.
  
  
  METHODS
  In vivo 31P magnetic resonance spectra were acquired from a 45-cm3 region surrounding the basal ganglia of 35 unmedicated depressed subjects and 18 comparison subjects.
  
  
  RESULTS
  beta-Nucleoside triphosphate, which arises primarily from beta-ATP, was 16% lower in the depressed subjects than in the comparison subjects.
  
  
  CONCLUSIONS
  The low level of beta-nucleoside triphosphate is consistent with an abnormality of high-energy phosphate metabolism in the basal ganglia of subjects with major depression.
authors.affiliation: Brain Imaging Center, McLean Hospital, Belmont, MA 02178, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Moore
authors.forename: J D
authors.initials: JD
authors.lastname: Christensen
authors.forename: B
authors.initials: B
authors.lastname: Lafer
authors.forename: M
authors.initials: M
authors.lastname: Fava
authors.forename: P F
authors.initials: PF
authors.lastname: Renshaw
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D001479:Basal Ganglia / Q000737:chemistry / Q000378:metabolism*; D003866:Depressive Disorder / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009705:Nucleosides / Q000032:analysis / Q000378:metabolism*; D010758:Phosphorus
chemical_list: D009705:Nucleosides; D010758:Phosphorus; D000255:Adenosine Triphosphate