Integrin signals and tumor growth control.
Integrins can trigger signals by activation of cytoplasmic tyrosine kinases, including pp125FAK. Preliminary evidence suggests that serine/threonine kinases such as ERKs may also be activated via integrins. Thus, there seems to be at least partial overlap between RTK signaling pathways and integrin signaling. In tumor cells, ectopic expression or over-expression of certain integrins such as alpha 5/beta 1 can result in reduced tumorigenesis. Presumably the effects of integrins on tumor growth are mediated by the integrin signaling pathway(s) involving FAK and ERKs. However, the precise mechanisms involved have not yet been elucidated.
Juliano
R L
RL
Department of Pharmacology, University of North Carolina at Chapel Hill, School of Medicine 27599, USA.
D016475:3T3 Cells; D000818:Animals; D016466:CHO Cells; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000502:physiology; D002455:Cell Division; D002645:Chickens; D006224:Cricetinae; D003598:Cytoskeletal Proteins / Q000502:physiology; D016326:Extracellular Matrix Proteins / Q000502:physiology; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; D006801:Humans; D016023:Integrins / Q000502:physiology*; D008024:Ligands; D051379:Mice; D009363:Neoplasm Proteins / Q000502:physiology*; D009369:Neoplasms / Q000473:pathology*; D010766:Phosphorylation; D011494:Protein Kinases / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D019030:Receptors, Vitronectin; D015398:Signal Transduction / Q000502:physiology*; D014407:Tumor Cells, Cultured
D015815:Cell Adhesion Molecules; D003598:Cytoskeletal Proteins; D016326:Extracellular Matrix Proteins; D016023:Integrins; D008024:Ligands; D009363:Neoplasm Proteins; D019030:Receptors, Vitronectin; C094340:integrin alphavbeta1; D011494:Protein Kinases; D011505:Protein-Tyrosine Kinases; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; C496050:PTK2 protein, human; C496051:Ptk2 protein, mouse; D017871:Calcium-Calmodulin-Dependent Protein Kinases