title: Responses of monkeys with pollinosis to two major allergens of Japanese cedar pollen.
abstract: We examined the responses of two Japanese monkeys with pollinosis to two major allergens (Cry j 1 and Cry j 2) of Japanese cedar pollen. The two monkeys (A and B) had specific IgE antibodies to the allergens and showed a strong positive reaction to both of them in the intradermal test. In the histamine release test with peripheral blood mononuclear cells (PBMC), monkey A showed a typical pattern similar to that seen in human patients, while monkey B released a low level of histamine. The proliferative response of PBMC to both allergens in monkey A was weak, but was typical in monkey B. From clinical as well as immunological points of view, these monkeys may be a suitable animal model for Japanese cedar pollinosis in humans.
authors.affiliation: Division of Wild Animal Medicine, Nippon Veterinary and Animal Science University, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hashimoto
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Nigi
authors.forename: S
authors.initials: S
authors.lastname: Saito
authors.forename: I
authors.initials: I
authors.lastname: Nakayama
authors.forename: T
authors.initials: T
authors.lastname: Narita
authors.forename: M
authors.initials: M
authors.lastname: Iwata
authors.forename: H
authors.initials: H
authors.lastname: Yasueda
authors.forename: Y
authors.initials: Y
authors.lastname: Taniguchi
authors.forename: M
authors.initials: M
authors.lastname: Kurimoto
authors.forename: S
authors.initials: S
authors.lastname: Inouye
authors.forename: M
authors.initials: M
authors.lastname: Sakaguchi
mesh_terms: D000485:Allergens / Q000276:immunology*; D000818:Animals; D000918:Antibody Specificity; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006636:Histamine Release; D006967:Hypersensitivity / Q000276:immunology*; D007073:Immunoglobulin E / Q000032:analysis*; D008213:Lymphocyte Activation / Q000276:immunology; D008251:Macaca / Q000276:immunology*; D008297:Male; D010940:Plant Proteins / Q000276:immunology*; D011058:Pollen / Q000276:immunology*; D012882:Skin Tests; D013601:T-Lymphocytes / Q000276:immunology; D014197:Trees / Q000276:immunology
chemical_list: D000485:Allergens; D010940:Plant Proteins; D007073:Immunoglobulin E