title: Effects of physical therapy on immunological parameters in patients with cerebrovascular diseases.
abstract: The effects of physical therapy on immunological parameters were evaluated in 22 patients (14 males, aged 68.1 +/- 9.9 years) with cerebrovascular diseases in a stable situation 3 to 6 months after the onset of stroke who were entered into a rehabilitation program in our hospital between 1990 and 1993. The proportion of CD4+ cells was significantly increased but that of CD8+ cells was decreased throughout the rehabilitation program, resulting in an increase in the ratio of CD4+/CD8+ cells. The lymphocyte response to phytohemagglutinin and concanavalin A was increased, while no significant differences were observed in CD3+ cells, natural killer cell activity, and serum levels of immunoglobulins, interleukin-1 beta, interleukin-2 and interleukin-6. These findings suggest that repeated physical exercise may activate the immune system, especially T-cell function, for possible prevention of infectious diseases that are often complicated in patients with cerebrovascular diseases.
authors.affiliation: Division of Rehabilitation, Kusatsu Branch Hospital, Gunma University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kurabayashi
authors.forename: K
authors.initials: K
authors.lastname: Kubota
authors.forename: I
authors.initials: I
authors.lastname: Machida
authors.forename: K
authors.initials: K
authors.lastname: Tamura
authors.forename: H
authors.initials: H
authors.lastname: Take
authors.forename: T
authors.initials: T
authors.lastname: Shirakura
mesh_terms: D016516:CD4-CD8 Ratio; D002561:Cerebrovascular Disorders / Q000276:immunology / Q000628:therapy*; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D008875:Middle Aged; D026741:Physical Therapy Modalities