Responses of monkeys with pollinosis to two major allergens of Japanese cedar pollen.
We examined the responses of two Japanese monkeys with pollinosis to two major allergens (Cry j 1 and Cry j 2) of Japanese cedar pollen. The two monkeys (A and B) had specific IgE antibodies to the allergens and showed a strong positive reaction to both of them in the intradermal test. In the histamine release test with peripheral blood mononuclear cells (PBMC), monkey A showed a typical pattern similar to that seen in human patients, while monkey B released a low level of histamine. The proliferative response of PBMC to both allergens in monkey A was weak, but was typical in monkey B. From clinical as well as immunological points of view, these monkeys may be a suitable animal model for Japanese cedar pollinosis in humans.
Hashimoto
M
M
Division of Wild Animal Medicine, Nippon Veterinary and Animal Science University, Tokyo, Japan.
Kobayashi
T
T
Nigi
H
H
Saito
S
S
Nakayama
I
I
Narita
T
T
Iwata
M
M
Yasueda
H
H
Taniguchi
Y
Y
Kurimoto
M
M
Inouye
S
S
Sakaguchi
M
M
D000485:Allergens / Q000276:immunology*; D000818:Animals; D000918:Antibody Specificity; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006636:Histamine Release; D006967:Hypersensitivity / Q000276:immunology*; D007073:Immunoglobulin E / Q000032:analysis*; D008213:Lymphocyte Activation / Q000276:immunology; D008251:Macaca / Q000276:immunology*; D008297:Male; D010940:Plant Proteins / Q000276:immunology*; D011058:Pollen / Q000276:immunology*; D012882:Skin Tests; D013601:T-Lymphocytes / Q000276:immunology; D014197:Trees / Q000276:immunology
D000485:Allergens; D010940:Plant Proteins; D007073:Immunoglobulin E