title: Efficacy of closantel against Fasciola hepatica in Korean native goats.
abstract: Closantel (Flukiver), a salicylanilide antiparasitic compound, was tested in Korean native goats infected with Fasciola hepatica. The goats were administered closantel once orally at a dose of 10 mg/kg body weight. Efficacy was monitored weekly by fecal examination of all infected animals starting the second week post-treatment and continuing for 3 weeks. Closantel elicited 80.3, 97.8 and 92.7% efficacy in goats with naturally-acquired fasciolosis at the second, third and fourth week post-treatment, respectively. It elicited a 100% efficacy in goats experimentally infected with F. hepatica metacercariae and treated at 18 weeks post-infection.
authors.affiliation: College of Veterinary Medicine, Chonnam National University, South Korea.
authors.forename: C G
authors.initials: CG
authors.lastname: Lee
authors.forename: S H
authors.initials: SH
authors.lastname: Cho
authors.forename: J T
authors.initials: JT
authors.lastname: Kim
authors.forename: C Y
authors.initials: CY
authors.lastname: Lee
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D005210:Fasciola hepatica / Q000187:drug effects*; D005211:Fascioliasis / Q000188:drug therapy / Q000662:veterinary*; D005243:Feces / Q000469:parasitology; D005260:Female; D015511:Goat Diseases / Q000188:drug therapy*; D006041:Goats; D008297:Male; D010270:Parasite Egg Count / Q000662:veterinary; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000188:drug therapy / Q000662:veterinary; D012458:Salicylanilides / Q000627:therapeutic use*
chemical_list: D000871:Anthelmintics; D012458:Salicylanilides; C023342:closantel