title: Probable nefazodone-induced mania in a patient with unreported bipolar disorder.
abstract: Nefazodone is a new antidepressant exhibiting properties of selective serotonin reuptake inhibition and serotonin-2 receptor antagonism. There has been only one other published case of induction of mania in a patient treated with nefazodone. This report describes a second case of probable induction of mania with nefazodone therapy and briefly reviews clinical and theoretical considerations involved in this process.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Texas A&M University College of Medicine, Scott & White Hospital and Clinic, Temple 76508, USA.
authors.forename: H A
authors.initials: HA
authors.lastname: Zaphiris
authors.forename: G D
authors.initials: GD
authors.lastname: Blaisdell
authors.forename: D M
authors.initials: DM
authors.lastname: Jermain
mesh_terms: D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects* / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000009:adverse effects; D001714:Bipolar Disorder / Q000139:chemically induced* / Q000175:diagnosis / Q000523:psychology; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D003891:Desipramine / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008875:Middle Aged; D010348:Patient Care Team; D010879:Piperazines; D011293:Premenstrual Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D014230:Triazoles / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D018687:Antidepressive Agents, Second-Generation; D000929:Antidepressive Agents, Tricyclic; D010879:Piperazines; D014230:Triazoles; C051752:nefazodone; D003891:Desipramine