Regulation of cell cycle synchronization by decapentaplegic during Drosophila eye development.
In the developing Drosophila eye, differentiation is coordinated with synchronized progression through the cell cycle. Signaling mediated by the transforming growth factor-beta-related gene decapentaplegic (dpp) was required for the synchronization of the cell cycle but not for cell fate specification. DPP may affect cell cycle synchronization by promoting cell cycle progression through the G2-M phases. This synchronization is critical for the precise assembly of the eye.
Penton
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A
McArdle Laboratory for Cancer Research and Laboratory of Genetics, University of Wisconsin Medical School, Madison, WI 53706, USA.
Selleck
S B
SB
Hoffmann
F M
FM
D000818:Animals; D019521:Body Patterning; D002453:Cell Cycle; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000648:ultrastructure; D016213:Cyclins / Q000378:metabolism; D004330:Drosophila / Q000235:genetics* / Q000502:physiology; D029721:Drosophila Proteins; D005123:Eye / Q000166:cytology; D005260:Female; D016193:G1 Phase; D016195:G2 Phase; D017344:Genes, Insect; D019476:Insect Proteins / Q000235:genetics* / Q000502:physiology; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology; D008938:Mitosis; D009154:Mutation; D017956:Photoreceptor Cells, Invertebrate / Q000166:cytology*; D011509:Proteoglycans / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction
D016213:Cyclins; D029721:Drosophila Proteins; D019476:Insect Proteins; D008562:Membrane Glycoproteins; D011509:Proteoglycans; C098128:dally protein, Drosophila; C064196:dpp protein, Drosophila