title: Comparative analysis of clinical manifestations of autosomal dominant polycystic kidney disease depending on linkage to chromosome 16.
abstract: The present study concerns 63 patients with autosomal polycystic kidney disease. In 35 patients the disease was linked to chromosome 16, and in the remaining 28 it was not linked to this chromosome. A comparative clinical analysis of the clinical manifestations of each of the forms was carried out using the objective criteria of age at onset of the initial clinical manifestations of ADPKD, age at onset of the hypertension syndrome, age at onset of the initial chronic renal failure and beginning of haemodialysis. The results show that the clinical manifestations of ADPKD in the patients with the unlinked from are milder and with a better prognosis.
authors.affiliation: Department of Nephrology, Medical University, Plovdiv, Bulgaria.
authors.forename: D
authors.initials: D
authors.lastname: Dimitrakov
authors.forename: N
authors.initials: N
authors.lastname: Bogdanova
authors.forename: T
authors.initials: T
authors.lastname: Despotov
mesh_terms: D000328:Adult; D002885:Chromosomes, Human, Pair 16; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D016891:Polycystic Kidney, Autosomal Dominant / Q000235:genetics* / Q000503:physiopathology; D011379:Prognosis