Prenatal diagnosis of ring chromosome 14 after intracytoplasmic sperm injection.
OBJECTIVE
To collect extensively abnormal cytogenetic results in pregnancies obtained after intracytoplasmic sperm injection (ICSI).


METHODS
Case report.


METHODS
University Hospital of Nantes, France.


METHODS
A couple with 5 years of primary infertility and severe male factor undergoing ICSI procedure.


METHODS
Ultrasound-guided transvaginal follicular aspiration, amniocentesis, and medical abortion.


METHODS
Serum levels of E2, beta-hCG, and fetal chromosomal karyotype.


RESULTS
Ultrasonic observation at 12 weeks revealed an 8-mm thick cystic hygroma in the nuchal area. Because the karyotypic analysis was [46,XX,r(14)/45,XX,-14], medical abortion was performed at 14 weeks, after the patients gave their informed consent.


CONCLUSIONS
According to the prevalence of this unusual chromosomal abnormality in humans, such abnormal cytogenetic results have to be collected extensively to assess the feasibility of using ICSI procedure.
Jean
M
M
Laboratoire de Biologie de la Reproduction, Centre Hospitalier Universitaire, Nantes, France.
Rival
J M
JM
Mensier
A
A
Mirallié
S
S
Lopes
P
P
Barrière
P
P
D000328:Adult; D002883:Chromosomes, Human, Pair 14; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012303:Ring Chromosomes