Two new aromatic constitutents from the rootwood of Aeschynomene mimosifolia.
The rootwood of Aeschynomene mimosifolia Vatke (Leguminosae) has yielded a new neoflavonoid, mimosifoliol (1), and an unusual C16-styrylcycloheptenone derivative, mimosifolenone (2). The structures of these compounds were determined on the basis of spectral analysis. Compound 1 demonstrated weak activity in DNA-strand scission assay, while compound 2 was found to be inactive. Mimosifoliol (1) was inactive toward several human cell lines, while 2 was moderately active against the KB cell line.
Fullas
F
F
Chemistry and Life Sciences Group, Research Triangle Institute, North Carolina 27709, USA.
Kornberg
L J
LJ
Wani
M C
MC
Wall
M E
ME
Farnsworth
N R
NR
Chagwedera
T E
TE
Kinghorn
A D
AD
D000179:Acrylates / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology*; D003508:Cycloheptanes / Q000302:isolation & purification* / Q000494:pharmacology; D004249:DNA Damage; D004354:Drug Screening Assays, Antitumor; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D013343:Styrenes / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D015030:Zimbabwe
D000179:Acrylates; D000972:Antineoplastic Agents, Phytogenic; D003508:Cycloheptanes; D010936:Plant Extracts; D013343:Styrenes; C102779:mimosifolenone; C102778:mimosifoliol; D006139:Guaiacol