title: [Trial of home anti-cancer chemotherapy with infusion of 5-FU and low-dose cisplatin].
abstract: We tried home anti-cancer chemotherapy for patients with advanced or recurrent cancer of the digestive system, using two disposable balloon pumps connected to an implantable drug delivery system via central venous line. There were 33 patients under 75 years old, including 20 cases of gastric cancer, 9 cases of colorectal cancer, 2 cases of cholangiocarcinoma and 2 cases of esophageal cancer enrolled in this study. The protocol was combined chemotherapy with continuous intravenous infusion of 5-FU (300 mg/body/day) and low-dose intravenous injection of cisplatin (5 mg/body/day) in 10-day courses for two weeks, and it was repeated 3 times for 6 weeks. Because of side effects such as nausea, vomiting and bone marrow suppression, treatment was discontinued in 12 cases with peritoneal cancer infiltration. In two of 10 with estimable disease, the reduction of the metastatic lymph node was observed, but no effect was shown in the colorectal metastatic liver tumor. Thanks to the portability of the pump with this method, the patient need not undergo hospitalization. Moreover, there is no renal dysfunction or other major side effects, quality of life is not compromised and a return to family and social life is possible. Thus, if the patient cannot take the oral nutrition, it is easy to start home hyper-alimentation.
authors.affiliation: Dept. of Surgery, Fukushima Rosai Hospital.
authors.forename: A
authors.initials: A
authors.lastname: Muto
authors.forename: Y
authors.initials: Y
authors.lastname: Ashino
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: A
authors.initials: A
authors.lastname: Kanno
authors.forename: A
authors.initials: A
authors.lastname: Moriyama
authors.forename: M
authors.initials: M
authors.lastname: Hiraga
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001650:Bile Duct Neoplasms / Q000188:drug therapy; D002945:Cisplatin / Q000008:administration & dosage; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004209:Disposable Equipment; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage; D018718:Home Infusion Therapy; D006801:Humans; D007260:Infusion Pumps; D015918:Infusion Pumps, Implantable; D013274:Stomach Neoplasms / Q000188:drug therapy*
chemical_list: D002945:Cisplatin; D005472:Fluorouracil