Alteration in sensory nerve function following electrical shock.
A study of the effects of electrical shock on peripheral nerve fibres is presented. Strength and duration of the applied shocks were similar to those encountered in a typical industrial electrical accident. The purpose of this study is: (i) to identify the electrophysiological and morphological change in nerve fibres after the application of electrical current shocks; (ii) to examine the ability of the peripheral nerve fibres to spontaneously regain function and; (iii) to demonstrate the usefulness of the sensory refractory spectrum as an additional technique in assessing the damage. Three groups of animals received twelve 4-ms electric field pulses of approximately 37 V/cm (n = 5), 75 V/cm (n = 9) and 150 V/cm (n = 6), respectively. Group 4 was a control group and received a direct application of 2 per cent lidocaine over the sciatic nerve for 30 min. Thermal effects of the shocks were negligible. The sensory refractory spectrum shows that electrical shock damage was mainly to the large, fast myelinated fibres and that higher field strengths do more damage. Also in a histological examination it was found that the more heavily shocked myelinated fibres had sustained more damage.
Abramov
G S
GS
Department of Surgery, University of Chicago, Illinois, USA.
Bier
M
M
Capelli-Schellpfeffer
M
M
Lee
R C
RC
D000200:Action Potentials / Q000502:physiology; D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D004556:Electric Injuries / Q000473:pathology / Q000503:physiopathology*; D004558:Electric Stimulation; D004594:Electrophysiology; D005260:Female; D008012:Lidocaine / Q000494:pharmacology; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure; D009413:Nerve Fibers, Myelinated / Q000502:physiology / Q000648:ultrastructure; D009431:Neural Conduction / Q000502:physiology; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D051381:Rats; D017207:Rats, Sprague-Dawley; D012032:Refractory Period, Electrophysiological / Q000502:physiology; D012584:Sciatic Nerve / Q000187:drug effects / Q000293:injuries* / Q000503:physiopathology / Q000648:ultrastructure; D009435:Synaptic Transmission / Q000502:physiology
D000779:Anesthetics, Local; D008012:Lidocaine