Lesions of the lateral parabrachial nucleus block the aversive motivational effects of both morphine and morphine withdrawal but spare morphine's discriminative properties.
This study examined if the aversive properties of morphine, the aversive properties of morphine withdrawal, and the discriminative properties of morphine are mediated by common neurobiological substrates. Lesions of the lateral parabrachial nucleus, which blocked the aversive properties of morphine in the conditioned taste aversion paradigm, also blocked the acquisition of conditioned place aversions to environments paired with the aversive properties of morphine withdrawal in morphine-dependent rats. When morphine and saline were used as cues in a discrimination task, however, both sham-operated and lesioned rats were able to solve the task.
Nader
K
K
Department of Anatomy and Cell Biology, University of Toronto, Ontario, Canada.
Bechara
A
A
van der Kooy
D
D
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001933:Brain Stem / Q000187:drug effects* / Q000502:physiology*; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D008297:Male; D009020:Morphine / Q000009:adverse effects* / Q000494:pharmacology*; D009042:Motivation; D011149:Pons / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013375:Substance Withdrawal Syndrome / Q000209:etiology / Q000503:physiopathology; D013649:Taste / Q000502:physiology
D009020:Morphine