Integrins as promiscuous signal transduction devices.
Recent studies suggest physical and functional interactions of glycosylphosphatidylinositol (GPI)-linked proteins (CD14, CD16b and CD87) with leukocyte beta 2 integrins. As discussed in this article, it now appears that beta 2 integrins relay proinflammatory information from GPI-anchored membrane receptors to the cytoplasm via exodomain interactions.
Petty
H R
HR
Dept of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
Todd
R F
RF
D000818:Animals; D006801:Humans; D016023:Integrins / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology*
D016023:Integrins