title: Hypothalamic-pituitary vascularization in pituitary stalk transection syndrome: is the pituitary stalk really transected? The role of gadolinium-DTPA with spin-echo T1 imaging and turbo-FLASH technique.
abstract: We examined 14 patients, aged 10-25 years, with idiopathic hypopituitarism. All presented an ectopic posterior pituitary at the median eminence with a hypoplastic anterior pituitary on magnetic resonance imaging (MRI). Eight patients had isolated growth hormone deficit (IGHD) and six had multiple hormone deficits (MPHD). Unenhanced MRI showed the pituitary stalk, which was extremely thin, in only three patients, while T1-weighted images obtained after intravenous injection of gadopentetate dimeglumine (Gd-DTPA) showed a thin pituitary stalk in seven patients (six with IGHD and one with MPHD), demonstrating a preserved vascular component of the stalk. MRI with Gd-DTPA was more sensitive than unenhanced MRI in detecting the pituitary stalk in patients with hypopituitarism with an ectopic posterior pituitary: the stalk was demonstrated in 50 % of the cases (seven patients), versus 21.4 % (three patients) by unenhanced MRI. The dynamic study of the hypothalamo-hypophyseal axis performed with turbo-FLASH sequences after bolus injection of Gd-DTPA showed the residual anterior pituitary to have arterial enhancement times, which suggests that an arterial system compensates for the absent or diminished blood supply from the portal system, independent of stalk detection.
authors.affiliation: Department of Radiology, IRCCS Policlinico S. Matteo, P. le C. Golgi, 1, I-27100 Pavia, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Genovese
authors.forename: M
authors.initials: M
authors.lastname: Maghnie
authors.forename: G
authors.initials: G
authors.lastname: Beluffi
authors.forename: A
authors.initials: A
authors.lastname: Villa
authors.forename: L
authors.initials: L
authors.lastname: Sammarchi
authors.forename: F
authors.initials: F
authors.lastname: Severi
authors.forename: R
authors.initials: R
authors.lastname: Campani
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D007018:Hypopituitarism / Q000175:diagnosis* / Q000209:etiology; D007033:Hypothalamus, Middle / Q000098:blood supply / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives*; D010902:Pituitary Gland / Q000002:abnormalities* / Q000098:blood supply / Q000473:pathology
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA