The human HCLS1 gene maps to chromosome 3q13 by fluorescence in situ hybridization.
The human HS1 gene (HCLS1, hematopoietic cell-specific Lyn substrate 1) expressed in human hematopoietic cells encodes a major substrate of protein-tyrosine kinase, p75HS1. This intracellular protein is involved in the signal transduction pathways that initiate at the antigen receptors of both B and T lymphocytes. Fluorescence in situ hybridization using a 2.0-kb cDNA and an 8.0-kb genomic DNA clone of HCLS1 as probes revealed that the gene maps to 3q13.
Egashira
M
M
Human Genetics, Nagasaki University School of Medicine, Japan. f0932@cc.nagasaki-u.ac.jp
Kitamura
D
D
Watanabe
T
T
Niikawa
N
N
D048868:Adaptor Proteins, Signal Transducing; D001798:Blood Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence
D048868:Adaptor Proteins, Signal Transducing; D001798:Blood Proteins; C061909:HCLS1 protein, human