Physiological requirement of aldosterone action on the Na+/K+ pump in ADH-stimulated Na+ absorption in renal epithelium.
Short-circuit current measurement in renal epithelium (A6) indicated that the amount of antidiuretic hormone-stimulated Na+ entry in aldosterone-treated cells exceeded the ability of the Na+/K(+)-pump to extrude Na+ in aldosterone-untreated cells. This suggests that, if aldosterone has no stimulatory action on Na+/K(+)-pump activity, the activity of Na+/K(+)-pump is not large enough to extrude Na(+) entering through antidiuretic hormone-activated Na(+)-permeant channels in the apical membrane. The present study concludes that the stimulatory action of aldosterone on the Na+/K+ pump is a physiological requirement in antidiuretic hormone-stimulated Na+ absorption.
Marunaka
Y
Y
Division of Respiratory Research, Hospital for Sick Children Research Institute, The University of Toronto, Canada.
D000042:Absorption / Q000187:drug effects; D000450:Aldosterone / Q000494:pharmacology*; D002460:Cell Line; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D005682:Gadolinium / Q000494:pharmacology; D007476:Ionophores / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D009761:Nystatin / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects*; D014668:Vasotocin / Q000494:pharmacology
D007476:Ionophores; D009761:Nystatin; D000450:Aldosterone; D012964:Sodium; D005682:Gadolinium; D000254:Sodium-Potassium-Exchanging ATPase; D014668:Vasotocin