title: Tumoral calcium pyrophosphate dihydrate deposition disease: cytopathologic findings on fine-needle aspiration.
abstract: Tumoral calcium pyrophosphate dihydrate deposition disease (CPPD) is a rare non-neoplastic entity which mimics primary or metastatic soft-tissue or skeletal malignancy. Fewer than a dozen cases have been reported in the literature with only histologic descriptions. We present cytologic findings of a unique case of CPPD in a 73-year-old black female with a history of end-stage renal disease. A fine-needle aspiration (FNA) was done on a 4 x 4-cm neck mass which was clinically thought to be malignant. Cytopathologic examination showed numerous macrophages with markedly distended cytoplasm and containing multiple yellowish-orange, short rhomboid crystals. These were strongly birefringent on polarized microscopy, consistent with CPPD crystals.
authors.affiliation: Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21287-6940, USA.
authors.forename: E A
authors.initials: EA
authors.lastname: Allen
authors.forename: S Z
authors.initials: SZ
authors.lastname: Ali
authors.forename: Y S
authors.initials: YS
authors.lastname: Erozan
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D002131:Calcium Pyrophosphate / Q000378:metabolism*; D002805:Chondrocalcinosis / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000473:pathology
chemical_list: D002131:Calcium Pyrophosphate