title: Integrins as promiscuous signal transduction devices.
abstract: Recent studies suggest physical and functional interactions of glycosylphosphatidylinositol (GPI)-linked proteins (CD14, CD16b and CD87) with leukocyte beta 2 integrins. As discussed in this article, it now appears that beta 2 integrins relay proinflammatory information from GPI-anchored membrane receptors to the cytoplasm via exodomain interactions.
authors.affiliation: Dept of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
authors.forename: H R
authors.initials: HR
authors.lastname: Petty
authors.forename: R F
authors.initials: RF
authors.lastname: Todd
mesh_terms: D000818:Animals; D006801:Humans; D016023:Integrins / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D016023:Integrins