[Antitubercular activity of lomefloxacin in an experiment].
The effect of lomefloxacin was studied on mice with experimental infection due to Mycobacterium tuberculosis. The antibiotic was administered in doses of 100 and 200 mg/kg. It was shown that the use of lomefloxacin for a month provided a lower death rate of the animals with progressing acute generalized tuberculosis, a lower level of the lesions in the internal organs and a lower number of the Mycobacterium isolates from them. The efficacy of the treatment depended on the drug dose. When lomefloxacin was used in a dose of 200 mg/kg, the survival rate was much higher and the number of the epithelial unicellular granulomas in the tissue of the lung and spleen was markedly decreased while with the lower dose the indices did not differ from those in the control.
Mozhokina
G N
GN
Sokolova
G B
GB
Makarova
O V
OV
Mikhaĭlova
L P
LP
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D000995:Antitubercular Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D024841:Fluoroquinolones; D007538:Isoniazid / Q000627:therapeutic use*; D008168:Lung / Q000187:drug effects / Q000473:pathology; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D015363:Quinolones / Q000627:therapeutic use*; D012016:Reference Values; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D015996:Survival Rate; D014376:Tuberculosis / Q000188:drug therapy* / Q000473:pathology
D000890:Anti-Infective Agents; D000995:Antitubercular Agents; D024841:Fluoroquinolones; D015363:Quinolones; C053091:lomefloxacin; D007538:Isoniazid