Is a (n inborn) deficiency of prostacyclin synthesis stimulating plasma factor associated with increased lipoprotein(a)?
Patients with the antiphospholipid syndrome as well as those with a lack in the prostacyclin synthesis stimulating plasma factor (PF) are prone to develop thrombophilia and are at a higher clinical risk for vascular disease. As patients with the antiphospholipid syndrome have been reported to show elevated lipoprotein (Lp)(a) levels, we re-examined all our patients known to have an inborn or an acquired persistent deficiency of PF. Their non-affected relatives served as controls. In addition, 36 patients suffering from clinically manifested atherosclerosis as well as 16 healthy adults, all of them having elevated Lp(a) levels (> 30 mg/dl), were screened for a PF deficiency. In fact, all the patients with a deficient PF activity showed elevated Lp(a) values. While the prevalence of PF deficiency ranges about 1-2%, in 7 (19%) patients with clinically manifested atherosclerosis and 3 (19%) healthy adults with elevated Lp(a) this defect was found. The findings demonstrate an association between PF deficiency and Lp(a), indicating a biochemical interaction which needs to be further elucidated.
Kritz
H
H
Wilhelm-Auerswald Atherosclerosis Research Group (ASF), Vienna, Austria.
Pidlich
J
J
O'Grady
J
J
Sinzinger
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000990:Antithrombin III / Q000032:analysis; D001161:Arteriosclerosis / Q000235:genetics / Q000378:metabolism*; D001685:Biological Factors / Q000097:blood / Q000172:deficiency* / Q000378:metabolism*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008661:Metabolism, Inborn Errors / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D010375:Pedigree; D011486:Protein C / Q000032:analysis; D017293:Protein S / Q000032:analysis
D001685:Biological Factors; D008055:Lipids; D017270:Lipoprotein(a); D011486:Protein C; D017293:Protein S; C057670:prostacyclin synthesis stimulating plasma factor; D000990:Antithrombin III