Antiphospholipid antibodies in patients with eosinophilia myalgia and toxic oil syndrome.
OBJECTIVE
To explore whether antiphospholipid antibodies (aPL) are markers of vascular related damage or merely evidence of toxic related autoimmunity, we investigated the presence of different aPL in patients with toxic oil syndrome (TOS) and compared the profile with patients with eosinophilia myalgia syndrome (EMS).


METHODS
Reactivity against cardiolipin, P-serine, P-inositol, and P-choline was investigated by ELISA in the blood of 266 patients with acute and chronic TOS, 25 healthy relatives of TOS patients, and 48 patients with EMS.


RESULTS
32% of TOS and 13% of EMS patients had IgG antibodies against cardiolipin and other polyanions. 20% of both TOS and EMS patients presented IgM antibodies against anionic and zwitterionic phospholipids. 36% of TOS healthy relatives had IgM antibodies against differently charged phospholipids. Among 200 patients with chronic TOS, there was no significant association between antibodies and clinical manifestations.


CONCLUSIONS
aPL with different specificity are present in a high percentage of patients with TOS and EMS. The significance of these antibodies remains unclear.
Carreira
P E
PE
Rheumatology Department, Hospital 12 de Octubre, Madrid, Spain.
Montalvo
M G
MG
Kaufman
L D
LD
Silver
R M
RM
Izquierdo
M
M
Gomez-Reino
J J
JJ
D017152:Antibodies, Antiphospholipid / Q000097:blood*; D002908:Chronic Disease; D016603:Eosinophilia-Myalgia Syndrome / Q000097:blood*; D005229:Fatty Acids, Monounsaturated; D005517:Foodborne Diseases / Q000097:blood; D006801:Humans; D010938:Plant Oils / Q000506:poisoning / Q000633:toxicity; D000074262:Rapeseed Oil; D013577:Syndrome
D017152:Antibodies, Antiphospholipid; D005229:Fatty Acids, Monounsaturated; D010938:Plant Oils; D000074262:Rapeseed Oil