Testosterone-producing benign cystic teratoma with virilism. A case report.
BACKGROUND
Mature cystic teratomas are common tumors in reproductive-age women. Biologic activity in a small percentage of these neoplasms is well recognized. Thyroid hormone is the most commonly secreted substance.


METHODS
A 25-year-old woman presented with a large abdominal mass and virilism. Preoperative evaluation revealed elevated creatinine and testosterone levels and anemia. Computed tomography (CT) showed fat-fluid levels and multiple calcifications within the mass and obstruction of the right kidney. At surgery a 30-cm left ovarian mass was removed. Left ovarian vein testosterone levels were markedly elevated. Pathology reported a mature cystic teratoma. Postoperatively the testosterone levels returned to normal.


CONCLUSIONS
In rare instances androgen production and virilization may occur with mature cystic teratoma.
Tomlinson
M W
MW
Department of Obstetrics and Gynecology, Grace Hospital/Wayne State University, Detroit, Michigan 48325, USA.
Alaverdian
A A
AA
Alaverdian
V
V
D000328:Adult; D003560:Cysts / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism*; D005260:Female; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging / Q000473:pathology; D007674:Kidney Diseases / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism*; D013724:Teratoma / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism*; D013739:Testosterone / Q000097:blood / Q000378:metabolism* / Q000502:physiology; D014057:Tomography, X-Ray Computed; D014770:Virilism / Q000097:blood / Q000209:etiology* / Q000503:physiopathology
D013739:Testosterone