New hypoglycemic constituents in "gymnemic acid" from Gymnema sylvestre.
Investigation of hypoglycemic activity of major saponin constituents from "gymnemic acid", a crude saponin fraction of G. sylvestre, exposed not only two new saponins, gymnemosides a (1) and b (2), but also gymnemoside b and gymnemic acid V (7) as active principles. Furthermore, an acetyl group linked 16- or 22-hydroxy group in 1 and 2 was found to migrate easily to primary 28-hydroxyl group, while acyl migration from 28-hydroxy group in 3 was little observed.
Murakami
N
N
Kyoto Pharmaceutical University, Japan.
Murakami
T
T
Kadoya
M
M
Matsuda
H
H
Yamahara
J
J
Yoshikawa
M
M
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D007194:India; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D012503:Saponins; D014315:Triterpenes; C007898:gymnemic acid