[Recommendations for treatment of paracetamol poisoning. Danish Medical Society, Study of the Liver].
Based on recent reports concerning the efficacy of N-acetylcysteine (NAC) in paracetamol (acetaminophen) poisoning, guidelines for treatment and control of these patients are reviewed by a study group under the Danish Association for the Study of the Liver. It is recommended that NAC-treatment is initiated immediately after referral and continued for 36 hours in all cases. Further NAC-treatment should not be discontinued before a decrease in INR has been observed.
Clemmesen
J O
JO
Medicinsk afdeling A-2101, Rigshospitalet, København.
Ott
P
P
Dalhoff
K P
KP
Astrup
L B
LB
Tage-Jensen
U
U
Poulsen
H E
HE
D000082:Acetaminophen / Q000506:poisoning*; D000111:Acetylcysteine / Q000008:administration & dosage / Q000627:therapeutic use*; D018712:Analgesics, Non-Narcotic / Q000506:poisoning*; D000931:Antidotes / Q000008:administration & dosage / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000209:etiology*; D003718:Denmark; D006801:Humans; D007262:Infusions, Intravenous; D011041:Poisoning / Q000188:drug therapy*
D018712:Analgesics, Non-Narcotic; D000931:Antidotes; D000082:Acetaminophen; D000111:Acetylcysteine