Cancer chemopreventive activity of resveratrol, a natural product derived from grapes.
Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity). In addition, it inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. These data suggest that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
Jang
M
M
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
Cai
L
L
Udeani
G O
GO
Slowing
K V
KV
Thomas
C F
CF
Beecher
C W
CW
Fong
H H
HH
Farnsworth
N R
NR
Kinghorn
A D
AD
Mehta
R G
RG
Moon
R C
RC
Pezzuto
J M
JM
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use; D016588:Anticarcinogenic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016587:Antimutagenic Agents / Q000494:pharmacology; D002273:Carcinogens; D002454:Cell Differentiation / Q000187:drug effects; D051545:Cyclooxygenase 1; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D007527:Isoenzymes / Q000378:metabolism; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control; D008565:Membrane Proteins; D051379:Mice; D009374:Neoplasms, Experimental / Q000517:prevention & control*; D010544:Peroxidases / Q000037:antagonists & inhibitors; D011230:Precancerous Conditions / Q000517:prevention & control; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use; D014407:Tumor Cells, Cultured
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016588:Anticarcinogenic Agents; D016587:Antimutagenic Agents; D002273:Carcinogens; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D008565:Membrane Proteins; D013267:Stilbenes; D010544:Peroxidases; D051545:Cyclooxygenase 1; C496511:PTGS1 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; C496512:Ptgs1 protein, mouse; C496513:Ptgs1 protein, rat; D000077185:Resveratrol