[Problems in creating insulin preparations with increased stability against proteolysis].
Chemical methods that accelerate the transport of insulin and other polypeptides across biological membranes and increase their resistance to enzymatic hydrolysis are reviewed. These methods include chemical modification of insulin macromolecules, the use of compounds that increase the permeability of biological membranes or inhibit enzymatic proteolysis, the hormone immobilization in a polymer coat protecting it against the aggressive environment, the incorporation of insulin into liposomes, etc. The advantages and drawbacks of these methods are analyzed, and promising lines of research in this field of applied biochemistry are described.
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D000595:Amino Acid Sequence; D004337:Drug Carriers; D004355:Drug Stability; D006801:Humans; D007328:Insulin / Q000138:chemical synthesis / Q000378:metabolism / Q000493:pharmacokinetics*; D008081:Liposomes; D008969:Molecular Sequence Data
D004337:Drug Carriers; D007328:Insulin; D008081:Liposomes