[Early diagnosis and treatment of cytomegalovirus polyradiculoneuritis in a child infected by HIV].
BACKGROUND
Axonal polyradiculopathy due to cytomegalovirus (CMV) in AIDS has been reported in adults but it is not well documented in children.


OBJECTIVE
We describe the elements of diagnosis and the outcome after anti-CMV therapy in a pediatric case.


METHODS
A 11-year-old boy with post-transfusional AIDS and low CD4 count (< 50/mm3) suffered from bilateral leg pain and weakness progressing within 15 days to paraplegia and cauda equina syndrome. Electromyography showed pure axonal neuropathy. Examination of the CSF showed increased proteins, low glucose concentration, neutrophilic pleiocytosis and positive detection of CMV by polymerase-chain reaction. The CMV viremia was positive. Treatment with ganciclovir and foscarnet allowed dramatical clinical improvement. Retinitis occurred during the maintenance therapy and was cured after reintroduction of the initial doses of ganciclovir and foscarnet. The child died five months later from a bacterial pneumopathy.


CONCLUSIONS
Children with advanced AIDS may benefit from early recognition and treatment of CMV polyradiculopathy. The interactions and cumulated toxicities between anti-CMV and anti-retroviral drugs must be considered. The prognosis remains poor for CMV neuropathy due to the severe immunodepression caused by the HIV infection.
Quartier
P
P
Service de pédiatrie générale, hôpital d'enfants Armand-Trousseau, Paris, France.
Khouri
J
J
Maout
F
F
Courpotin
C
C
Dollfus
C
C
Tabone
M D
MD
Leverger
G
G
Lasfargues
G
G
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis*; D002648:Child; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D004359:Drug Therapy, Combination; D017245:Foscarnet / Q000008:administration & dosage / Q000627:therapeutic use; D015774:Ganciclovir / Q000008:administration & dosage / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D011129:Polyradiculoneuropathy / Q000821:virology*
D017245:Foscarnet; D015774:Ganciclovir