title: Increased renal formation of thromboxane A2 and prostaglandin F2 alpha in heart failure.
abstract: Renal formation of the vasoconstrictor prostaglandins thromboxane A2 (TXA2) and prostaglandin F2 alpha (PGF2 alpha) was investigated in 25 patients with cardiac failure, divided into New York Heart Association functional classes I to IV, and in eight healthy control subjects. Plasma renin activity (PRA) and hemodynamic parameters were also investigated. Renal vasoconstrictor eicosanoid formation, measured in urinary daily excretion, was not different between patients in class I and control subjects. Class II to IV patients showed progressively increasing production of PGF2 alpha (F = 49.8, p < 0.001, analysis of variance) and TXA2 (F = 37.8, p < 0.002). PGF2 alpha excretion peaked in class IV (+ 1266% vs class I, p < 0.001). Compared with class I, urinary excretion of thromboxane B2 was + 816% in class III and + 1561% in class IV (both p < 0.001). PRA was significantly increased only in class IV (+ 1558%, p < 0.001). The current results indicate a progressive increase in renal production of vasoconstrictor eicosanoids directly related to New York Heart Association class and suggest that these prostanoids may have a role in deterioration of renal function.
authors.affiliation: Clinica Medica Generale e Cardiologia, University of Florence, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Castellani
authors.forename: B
authors.initials: B
authors.lastname: Paladini
authors.forename: R
authors.initials: R
authors.lastname: Paniccia
authors.forename: C
authors.initials: C
authors.lastname: Di Serio
authors.forename: B
authors.initials: B
authors.lastname: Vallotti
authors.forename: A
authors.initials: A
authors.lastname: Ungar
authors.forename: S
authors.initials: S
authors.lastname: Fumagalli
authors.forename: C
authors.initials: C
authors.lastname: Cantini
authors.forename: L
authors.initials: L
authors.lastname: Poggesi
authors.forename: G G
authors.initials: GG
authors.lastname: Neri Serneri
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D016022:Case-Control Studies; D015237:Dinoprost / Q000096:biosynthesis* / Q000652:urine; D005260:Female; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology / Q000652:urine*; D006439:Hemodynamics; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008875:Middle Aged; D012720:Severity of Illness Index; D013928:Thromboxane A2 / Q000096:biosynthesis* / Q000652:urine
chemical_list: D013928:Thromboxane A2; D015237:Dinoprost