title: Chemotherapy in Hodgkin's disease.
abstract: OBJECTIVE
  To assess the efficacy of primary chemotherapy in patients with clinically staged Hodgkin's disease.
  
  
  METHODS
  Non randomized study.
  
  
  METHODS
  Pediatric Oncology Division of Regional Cancer Center.
  
  
  METHODS
  Twenty nine children with Hodgkin's disease.
  
  
  METHODS
  Chemotherapy was given to 21 patients whose parents agreed for the same. Sixteen children received COPP regimen and 5 received MOPP regimen.
  
  
  RESULTS
  Complete remission was achieved in 19 patients. The relapse free survival and overall survival in these patients were 76% and 86%, respectively at 5 years. There was no death related to chemotherapy toxicity.
  
  
  CONCLUSIONS
  Combination chemotherapy is an effective modality of treatment for children with Hodgkin's disease.
authors.affiliation: Department of Pediatric Oncology, Regional Cancer Center, Trivandrum.
authors.forename: P K
authors.initials: PK
authors.lastname: Kumari
authors.forename: V G
authors.initials: VG
authors.lastname: Chellam
authors.forename: J
authors.initials: J
authors.lastname: Madhavan
authors.forename: K
authors.initials: K
authors.lastname: Ratheesan
authors.forename: G R
authors.initials: GR
authors.lastname: Pillai
authors.forename: S R
authors.initials: SR
authors.lastname: Kumar
authors.forename: M K
authors.initials: MK
authors.lastname: Nair
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000008:administration & dosage; D018572:Disease-Free Survival; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008466:Mechlorethamine / Q000008:administration & dosage; D011241:Prednisone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D015996:Survival Rate; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone