[Duodenal ulcer: clinical significance of adaptation defects in the system of neurohumoral regulation].
Radioimmunoassay was used to determine prostaglandin (PGE-2) and cyclic nucleotides (cAMP and cGMP) concentrations in the serum before, 1 and 2 hours after standard test breakfast (5066 kJ) in 65 patients with duodenal ulcer. Basal hyperproduction of prostaglandins and cyclic nucleotides were interpreted as an adaptation-compensatory mechanism. The unbalance of their aftermeal reactions persistent even in ulcer healing may belong to factors of the disease progression.
Eremina
E I
EI
Mordva State University of NP Ogareva, Saransk.
D000220:Adaptation, Biological; D000328:Adult; D001706:Biopsy; D000242:Cyclic AMP / Q000097:blood*; D006152:Cyclic GMP / Q000097:blood*; D015237:Dinoprost / Q000097:blood*; D015232:Dinoprostone / Q000097:blood*; D004381:Duodenal Ulcer / Q000097:blood* / Q000473:pathology; D016145:Endoscopy, Digestive System; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
D015237:Dinoprost; D000242:Cyclic AMP; D006152:Cyclic GMP; D015232:Dinoprostone