Syringin 4-O-beta-glucoside, a new phenylpropanoid glycoside, and costunolide, a nitric oxide synthase inhibitor, from the stem bark of Magnolia sieboldii.
Syringin 4-O-beta-glucoside (1), a new phenylpropanoid glycoside, and costunolide (2) were isolated from the stem bark of Magnolia sieboldii. The structures were determined by spectroscopic and chemical methods. Costunolide (2) exhibited strong nitric oxide synthase inhibitory activity in the endotoxin-activated murine macrophage, J774.1.
Park
H J
HJ
Department of Botanical Resources, Sangji University, Wonju, Korea.
Jung
W T
WT
Basnet
P
P
Kadota
S
S
Namba
T
T
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004396:Coloring Agents; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D006868:Hydrolysis; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007785:Lactose / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D019441:Plant Epidermis / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet; D013778:Tetrazolium Salts; D013844:Thiazoles; D007783:Lactones
D004396:Coloring Agents; D004791:Enzyme Inhibitors; D007166:Immunosuppressive Agents; D007785:Lactose; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D012717:Sesquiterpenes; D013778:Tetrazolium Salts; D013844:Thiazoles; C103979:syringin 4-O-beta-glucoside; C002602:costunolide; D007783:Lactones; C022616:thiazolyl blue