Gap junctions are found between iris sphincter smooth muscle cells but not in the ciliary muscle of human and monkey eyes.
Physiological studies indicate that in primate ciliary muscle there is little or no spread of electrical activity from cell to cell. To clarify to what extent primate intraocular smooth muscles express the structural correlate of electrical coupling, the localization of gap junctions in the ciliary and the iris sphincter muscle of human and monkey (Macaca fascicularis) eyes was analysed using electronmicroscopy and connexin43 immunocytochemistry. With both methods, numerous gap junctions were identified in the iris sphincter of both species, while no such junctions were observed between individual smooth muscle cells in the ciliary muscle. Both ciliary and iris sphincter smooth muscle cells were connected by numerous adherens-type junctions. These results further underline that primate ciliary muscle is an atypical smooth muscle which shares many common features with striated skeletal muscle.
Samuel
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Department of Anatomy II, University of Erlangen-Nürnberg, Germany.
Lütjen-Drecoll
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Tamm
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ER
D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D018031:Connexin 43 / Q000032:analysis; D017629:Gap Junctions / Q000648:ultrastructure*; D006801:Humans; D007150:Immunohistochemistry; D007498:Iris / Q000737:chemistry / Q000648:ultrastructure*; D008252:Macaca fascicularis; D008854:Microscopy, Electron; D008875:Middle Aged; D009130:Muscle, Smooth / Q000737:chemistry / Q000648:ultrastructure*; D009801:Oculomotor Muscles / Q000737:chemistry / Q000648:ultrastructure*
D018031:Connexin 43