Distribution of the HLA-A9 antigen family (A23, A24 and A2403).
Characterization of 50 local anti-HLA-A9 (A23 and/or A24) sera against the HLA-A2403 antigen allowed the retrospective assignment of A2403 and the verification of A23 and A24 specificities in a panel of 9196 volunteer bone marrow donors. The six A2403 positive subjects identified were confirmed by PCR using four sequence-specific primer mixtures. Population analysis showed the distribution and HLA-A/B linkage disequilibrium of HLA-A23 and A24 to be typical of a Northern European Caucasoid population. HLA-A2403 has a phenotype frequency of 0.00065 (gene frequency-0.00033) and is in linkage disequilibrium with HLA-B63 and possibly B35.
Thomas
M
M
Regional Tissue Typing Laboratory, National Blood Transfusion Service (Wales), Cardiff, U.K.
Street
J
J
Fussell
H
H
Guttridge
M
M
Darke
C
C
D001853:Bone Marrow / Q000276:immunology*; D005060:Europe; D005787:Gene Frequency; D008040:Genetic Linkage; D015234:HLA-A Antigens / Q000235:genetics / Q000276:immunology*; D006801:Humans; D014019:Tissue Donors
D015234:HLA-A Antigens; C037709:HLA-A9 antigen