title: Prevention of infection in a patient with chronic idiopathic neutropenia undergoing coronary bypass surgery with peri-operative G-CSF.
abstract: The prevention of postoperative infection complications in a patient with chronic idiopathic neutropenia treated with granulocyte colony stimulating factor (G-CSF) is reported. A 48-year-old woman who presented with chronic idiopathic neutropenia causing life-long recurrent infections, and postoperative suppurative wound infections, presented for elective coronary artery surgery. The patient was successfully treated with G-CSF, resulting in a significantly higher neutrophil count and no infection complications in the peri-operative period. Peri-operative G-CSF therapy in patients with chronic idiopathic neutropenia is effective in increasing the total neutrophil count, and decreasing infection complications.
authors.affiliation: Monash Medical Centre, Clayton, Victoria, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Shapiro
authors.forename: G
authors.initials: G
authors.lastname: Fetherston
authors.forename: G
authors.initials: G
authors.lastname: Richardson
mesh_terms: D002908:Chronic Disease; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000601:surgery; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D009503:Neutropenia / Q000150:complications*; D011292:Premedication; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D016179:Granulocyte Colony-Stimulating Factor