title: [The effect of recombinant human colony stimulating factor (G-CSF) on the function of human blood and urinary leukocytes].
abstract: To study the function of leukocyte in urinary tract infection (UTI), the effect of granulocyte colony-stimulating factor (G-CSF) and various osmolarities on the function were studied. The superoxide production of blood leukocytes increased by treatment of G-CSF with its dose dependency. This effect was not observed in urinary leukocytes. This increased function was well preserved even in higher osmotic atmosphere when previously treated by the G-CSF. Therefore, urinary leukocyte activated by G-CSF and migrating from the blood through the tissue may still have its function and work in the patients with UTI.
authors.affiliation: Department of Urology, Gifu University School of Medicine.
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: M
authors.initials: M
authors.lastname: Kuriyama
authors.forename: S
authors.initials: S
authors.lastname: Ishihara
authors.forename: Y
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
authors.forename: Y
authors.initials: Y
authors.lastname: Kawada
mesh_terms: D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D006801:Humans; D007962:Leukocytes / Q000187:drug effects* / Q000502:physiology; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D009994:Osmolar Concentration; D011994:Recombinant Proteins / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism; D014556:Urine / Q000166:cytology*
chemical_list: D011994:Recombinant Proteins; D013481:Superoxides; D016179:Granulocyte Colony-Stimulating Factor