title: EITS changes following oleic acid induced lung water.
abstract: We present the results of using electrical impedance tomographic spectroscopy (EITS) to follow the changes in lung water induced by oleic acid. Measurements were made on three goats before and after the injection of oleic acid. In addition to the EITs measurements, lung water was also measured using a double-indicator technique. Large falls in lung electrical impedance were seen as a result of the increase in lung water but the size of the fall was a function of the frequency at which the measurements were made. These changes have been modelled using the Cole equation. Four-electrode measurements were also made on two extracted porcine lungs and Cole equation modelling carried out following the introduction of saline into the lungs. Results were similar in the two sets of animal experiments.
authors.affiliation: Department of Medical Physics, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: B H
authors.initials: BH
authors.lastname: Brown
authors.forename: R
authors.initials: R
authors.lastname: Flewelling
authors.forename: H
authors.initials: H
authors.lastname: Griffiths
authors.forename: N D
authors.initials: ND
authors.lastname: Harris
authors.forename: A D
authors.initials: AD
authors.lastname: Leathard
authors.forename: L
authors.initials: L
authors.lastname: Lu
authors.forename: A H
authors.initials: AH
authors.lastname: Morice
authors.forename: G R
authors.initials: GR
authors.lastname: Neufeld
authors.forename: P
authors.initials: P
authors.lastname: Nopp
authors.forename: W
authors.initials: W
authors.lastname: Wang
mesh_terms: D000818:Animals; D001834:Body Water / Q000378:metabolism*; D017097:Electric Impedance; D006041:Goats; D006801:Humans; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects* / Q000378:metabolism*; D008954:Models, Biological; D019301:Oleic Acid / Q000633:toxicity*; D011654:Pulmonary Edema / Q000139:chemically induced / Q000175:diagnosis / Q000378:metabolism; D012128:Respiratory Distress Syndrome / Q000175:diagnosis; D013552:Swine; D014054:Tomography / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis
chemical_list: D019301:Oleic Acid