title: [Factors influencing the survival of children with Non-Hodgkin's disease].
abstract: Based on the results of examinations and treatment of children aged under 15 years, the authors analyze the factors influencing the survival of patients with non-Hodgkin's disease. The stage, site, histological structure, cytological type of a tumor, signs of intoxication, levels of lactate dehydrogenase, total protein and albumin, sex, and the count of leukocytes were found to affect the survival of children with non-Hodgkin's disease. Moreover, in patients receiving, in addition to chemoradiation, therapy, interferon preparations, and T-activin, the survival was much higher than that in untreated children. Intensified treatment with higher-dose methotrexate largely altered the predictive value of the majority of these factors, as evidenced by the lower informative value while analyzing by the method of Shennon. The findings should be used in developing treatment regimens for children with non-Hodgkin's disease.
authors.affiliation: NII of Pediatric Oncology, ONTs RAMN, Moscow.
authors.forename: A V
authors.initials: AV
authors.lastname: Kiselev
mesh_terms: D000293:Adolescent; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007958:Leukocyte Count; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D008297:Male; D009367:Neoplasm Staging; D012709:Serum Albumin / Q000378:metabolism; D012737:Sex Factors; D015996:Survival Rate
chemical_list: D012709:Serum Albumin; D007770:L-Lactate Dehydrogenase