title: Hepatitis C virus-related fibrosing cholestatic hepatitis after renal transplantation.
abstract: Fibrosing cholestatic hepatitis is a well-described syndrome in patients with immunodeficiency and chronic hepatitis B. It is clinically, biologically, and histologically characterized by rapidly progressive hepatic failure, a mildly elevated serum aminotransferase level, an extensive periportal fibrosis associated with intense cholestasis, mild inflammatory cellular infiltrate, no cirrhosis, and a high hepatocellular level expression of B viral antigens. This syndrome reflected a direct hepatocytopathic injury linked to high intrahepatic viral antigen expression. Because the syndrome of fibrosing cholestatic hepatitis has not been described in chronic hepatitis C, we report the first well-characterized case in a renal transplant patient with chronic hepatitis C and discuss the clinical and pathogenic implications of such a syndrome in this setting.
authors.affiliation: Unité d'Hépatologie et Service de Transplantation Rénale, Hôpital Necker, Paris, France.
authors.forename: H
authors.initials: H
authors.lastname: Zylberberg
authors.forename: F
authors.initials: F
authors.lastname: Carnot
authors.forename: M F
authors.initials: MF
authors.lastname: Mamzer
authors.forename: G
authors.initials: G
authors.lastname: Blancho
authors.forename: C
authors.initials: C
authors.lastname: Legendre
authors.forename: S
authors.initials: S
authors.lastname: Pol
mesh_terms: D000328:Adult; D002779:Cholestasis / Q000209:etiology*; D002908:Chronic Disease; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008103:Liver Cirrhosis / Q000209:etiology*; D017093:Liver Failure / Q000209:etiology*; D008297:Male