title: [Pathohistologic and ultrastructural features of drug-induced membranous glomerulonephritis].
abstract: Nephrobiopsies of 20 patients with drug-induced membranous glomerulonephritis were studied. Renal injury was produced by diuretics (7 patients), gold salts (6), penicillamine (4), captopril (3). Drug-induced membranous glomerulonephritis in contrast to idiopathic one ran a benign course after proper therapy based on discontinuation of the drug. Main pathomorphological features of secondary membranous glomerulonephritis that help to differentiate it from the primary one were established: absence of total injury of the glomeruli, hypercellularity of the damaged glomeruli, pathomorphological changes only of the part of the capillary loops, presence of both subepithelial and mesangial deposits.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Pospishil'
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002196:Capillaries / Q000187:drug effects / Q000473:pathology; D002216:Captopril / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004232:Diuretics / Q000009:adverse effects*; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology / Q000473:pathology*; D015433:Glomerulonephritis, Membranous / Q000139:chemically induced / Q000473:pathology*; D006046:Gold / Q000009:adverse effects*; D006801:Humans; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000009:adverse effects*
chemical_list: D004232:Diuretics; D006046:Gold; D002216:Captopril; D010396:Penicillamine