Distribution of HLA-A and B antigens in northeastern-Thais.
The phenotype and gene frequencies of HLA class I were studied in the Northeastern Thai population. Blood samples were collected from 100 unrelated healthy Northeastern Thais. HLA-A and B antigens were typed by using the standard microlymphocytotoxicity test. Twelve HLA-A and twenty-five HLA-B antigens were found in this population. HLA-A2, A24, A11 and the HLA-B46, B15, B22 antigens are commonly found in this group. Linkage disequilibrium analysis indicated the existence of fifteen haplotypes. The HLA-A2, B46 haplotype was the most common. These results will be useful for further studies in anthropology, organ transplantation and MHC associated disease in Northeastern Thais.
Romphruk
A
A
Blood Transfusion Centre, Faculty of Medicine, Khon Kaen University, Thailand.
Burusrux
S
S
Puapairoj
C
C
Urwijitaroon
Y
Y
Romphruk
A
A
Leelayuwat
C
C
D005787:Gene Frequency / Q000235:genetics*; D005828:Genetics, Population; D015234:HLA-A Antigens / Q000032:analysis / Q000235:genetics*; D015235:HLA-B Antigens / Q000032:analysis / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D015810:Linkage Disequilibrium; D010641:Phenotype; D012424:Rural Population; D013601:T-Lymphocytes / Q000276:immunology; D013785:Thailand
D015234:HLA-A Antigens; D015235:HLA-B Antigens