Genetic control of biological rhythms: independent expression of each rhythm parameter.
Biological rhythm whose pattern approaches a sinusoidal curve can be characterized by four parameters: Period, Mesor, Acrophase and Amplitude. Inheritance patterns of these parameters were assessed by monitoring White Blood Cell (WBC) count rhythms of C57BL/6J mice, BALB/c mice and the F1 progeny prior and after injection of Cisplatinum at either 0900, 1500, 2100, or 0300. All untreated mice exhibited similar WBC rhythms while a variety of rhythm phenotypes was revealed among the injected mice. Analyses of the variety in the parental strains and F1 progeny suggested that each of the rhythm parameters is independently controlled.
Peleg
L
L
Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Israel.
Zvulunov
A
A
Ashkenazi
I E
IE
D000704:Analysis of Variance; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002945:Cisplatin / Q000008:administration & dosage / Q000494:pharmacology*; D003433:Crosses, Genetic; D005838:Genotype; D007274:Injections, Intraperitoneal; D007958:Leukocyte Count / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010507:Periodicity
D000970:Antineoplastic Agents; D002945:Cisplatin