title: Increased circulating nerve growth factor is directly correlated with disease activity in juvenile chronic arthritis.
abstract: OBJECTIVE
  To determine the circulating serum concentrations of nerve growth factor (NGF) and compare them with indices of disease activity in juvenile chronic arthritis.
  
  
  METHODS
  NGF concentrations were evaluated with a two site immunoenzymatic assay (ELISA), in 17 children with systemic, 39 with polyarticular, and 24 with pauciarticular onset juvenile chronic arthritis. Each subset was divided according to different variables, appropriate to each subset, reflecting active and inactive disease.
  
  
  RESULTS
  NGF concentrations were significantly higher in children with systemic [254 (SD 256.1) pg ml-1; P < 0.001], polyarticular [165.2 (300.8) pg ml-1; P < 0.05], and pauciarticular [106.8 (111.8) pg ml-1; P < 0.005] onset juvenile chronic arthritis than in controls. In all subsets, NGF concentrations were higher in the active than in the inactive phase of the disease. A significant direct correlation between NGF concentrations and erythrocyte sedimentation rate was found both in the systemic and in the polyarticular onset juvenile chronic arthritis.
  
  
  CONCLUSIONS
  The increase in NGF concentrations in all juvenile chronic arthritis subsets and the correlation with disease activity suggest that NGF may take an active part in joint inflammation.
authors.affiliation: Department of Paediatrics, University of Florence, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Falcini
authors.forename: M
authors.initials: M
authors.lastname: Matucci Cerinic
authors.forename: A
authors.initials: A
authors.lastname: Lombardi
authors.forename: S
authors.initials: S
authors.lastname: Generini
authors.forename: A
authors.initials: A
authors.lastname: Pignone
authors.forename: P
authors.initials: P
authors.lastname: Tirassa
authors.forename: M
authors.initials: M
authors.lastname: Ermini
authors.forename: L
authors.initials: L
authors.lastname: Lepore
authors.forename: G
authors.initials: G
authors.lastname: Partsch
authors.forename: L
authors.initials: L
authors.lastname: Aloe
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001171:Arthritis, Juvenile / Q000097:blood* / Q000188:drug therapy; D001799:Blood Sedimentation; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008954:Models, Biological; D009414:Nerve Growth Factors / Q000097:blood*; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009414:Nerve Growth Factors; D011239:Prednisolone