title: Quantification of FISH-painted chromosome aberrations after domestic radon exposure.
abstract: Chromosome painting (target chromosomes 1, 4, 12) was performed in peripheral lymphocytes from 25 occupants of nine houses with indoor radon concentrations of 210-3000 Bqm-3. Compared to a control group, the mean frequency of symmetrical translocations of the radon group was slightly but not significantly (p < 0.10) increased. A similar tendency became apparent for a comparison of two groups of subjects with cumulative radon exposures above and below 2800 Bqm-3 y. It is concluded that FISH-based measurements of stable symmetrical translocations should reflect the cumulative radon exposure to haematopoietic compartments such as the red bone marrow rather than to mature blood lymphocytes. Since, however, radon-derived bone marrow doses are low and control frequencies of translocations are very high (about 10-fold higher than the value for conventionally scored dicentrics), the observed relative increase (1.5-fold) of the translocation frequency in blood lymphocytes is too small to discriminate chronic radon exposure from background.
authors.affiliation: GSF-National Research Center for Environment and Health, Institute of Radiobiology, Neuherberg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Bauchinger
authors.forename: H
authors.initials: H
authors.lastname: Braselmann
authors.forename: U
authors.initials: U
authors.lastname: Kulka
authors.forename: R
authors.initials: R
authors.lastname: Huber
authors.forename: V
authors.initials: V
authors.lastname: Georgiadou-Schumacher
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000396:Air Pollutants, Radioactive / Q000009:adverse effects*; D016902:Air Pollution, Indoor / Q000009:adverse effects*; D002274:Carcinogens, Environmental / Q000009:adverse effects*; D002648:Child; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D011886:Radon / Q000009:adverse effects*; D014178:Translocation, Genetic
chemical_list: D000396:Air Pollutants, Radioactive; D002274:Carcinogens, Environmental; D011886:Radon