title: [Lipid derivatives of sarcolysin, methotrexate and rubomycin].
abstract: To change the pharmacokinetic properties of the known antitumor agents sarcolysine, rubomycin, and methotrexate, their lipid derivatives were synthesized with the residues of rac-1,2-dioleoylglycerol and heptadecyl alcohol. An ether lipid analog, 3-sarcolysyl 2-methyl-1-octadecyl-sn-glycerol, with the lipid moiety being itself an antineoplastic agent was also obtained.
authors.forename: E L
authors.initials: EL
authors.lastname: Vodovozova
authors.forename: P Iu
authors.initials: PIu
authors.lastname: Nikol'skiĭ
authors.forename: I I
authors.initials: II
authors.lastname: Mikhalev
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Molotkovskiĭ
mesh_terms: D003630:Daunorubicin / Q000031:analogs & derivatives*; D008055:Lipids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008558:Melphalan / Q000031:analogs & derivatives*; D008727:Methotrexate / Q000031:analogs & derivatives*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D008055:Lipids; D008558:Melphalan; D008727:Methotrexate; D003630:Daunorubicin