[An EPR study of the joint action of sodium nitrite and whole-body irradiation on animal tissues].
Changes in metabolic paramagnetic centers of the liver, kidney, spleen, brain and heart tissues, and blood after sodium nitrite intraperitoneal administration irradiation, or combined action of sodium nitrite and irradiation on mice, were studied using the EPR method. It was shown that irradiation of mice after sodium nitrite administration enhanced the effects induced by sodium nitrite alone: the levels of nitrosyl complexes Heme-NO in the tissues, cytochrome P-450 inhibition, and MetHb were higher.
Kudriavtsev
M E
ME
Dmitrieva
O N
ON
Kuropteva
Z V
ZV
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D004578:Electron Spin Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods; D006418:Heme / Q000378:metabolism / Q000528:radiation effects; D006900:Hydroxylation / Q000187:drug effects / Q000528:radiation effects; D008706:Methemoglobin / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000378:metabolism; D012977:Sodium Nitrite / Q000633:toxicity*; D013997:Time Factors; D014916:Whole-Body Irradiation / Q000009:adverse effects*
D009569:Nitric Oxide; D006418:Heme; D008706:Methemoglobin; D003577:Cytochrome P-450 Enzyme System; D012977:Sodium Nitrite