Acute hepatitis and drug-related lupus induced by minocycline treatment.
Minocycline is widely prescribed for long-term treatment in acne. Major side effects are rare and include hepatitis and drug-related lupus. Hepatitis can be early and acute or late and chronic, whereas lupus presents as a tardive and insidious disease. We report a case of minocycline-induced lupus initially presenting as acute hepatitis, evolving to chronic cytolysis, in a young man treated for facial acne.
Golstein
P E
PE
Department of Gastroenterology, Erasmus Hospital, Université Libre de Bruxelles, Belgium.
Deviere
J
J
Cremer
M
M
D000152:Acne Vulgaris / Q000188:drug therapy; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced*; D008297:Male; D008911:Minocycline / Q000009:adverse effects* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D008911:Minocycline