Synthesis and pharmacological evaluation of 5,6-dihydrobenzo[f] cinnolin-2(3H)ones analogues of antihypertensive and antiaggregating benzo[h]cinnolinones.
Two new dihydrobenzo[f]cinnolin-2(3H)ones (4a,b) have been synthesized and tested for their hypotensive, antihypertensive and antiaggregating activities in comparison with the lead 8-acetylamino-4,4a,5,6-tetrahydrobenzo[h]cinnolin-3(2H)-one 1. In vivo tests indicated that 4a,b displayed hypotensive and antihypertensive properties weaker than the model compound. On the contrary both compounds were more potent than 1 in inhibiting collagen-induced platelet aggregation.
Pinna
G A
GA
Istituto di Chimica Farmaceutica, Università di Sassari, Italy.
Curzu
M M
MM
Fraghì
P
P
Gavini
E
E
D'Amico
M
M
D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry / Q000494:pharmacology*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000959:Antihypertensive Agents; D009281:Naphthalenes; D010975:Platelet Aggregation Inhibitors