Liver cirrhosis due to methotrexate in a patient with rheumatoid arthritis.
A 49-year-old female with rheumatoid arthritis developed liver cirrhosis after a cumulative dosage of 6 g methotrexate (MTX). There were mild liver enzyme abnormalities, decreased liver synthesis function and possible signs of portal hypertension. After stopping MTX all laboratory abnormalities disappeared except for a mild thrombocytopenia. Risk factors and guidelines for monitoring liver toxicity during MTX treatment in rheumatoid arthritis are discussed.
ter Borg
E J
EJ
Department of Internal Medicine, Sint Antonius Hospital, Nieuwegein, Netherlands.
Seldenrijk
C A
CA
Timmer
R
R
D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000139:chemically induced* / Q000473:pathology; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged
D008727:Methotrexate