title: Hemostasis parameters during ovarian stimulation for in vitro fertilization: results of a prospective study.
abstract: OBJECTIVE
  To evaluate the effect of IVF-ET on the hemostatic system.
  
  
  METHODS
  Prospective clinical study.
  
  
  METHODS
  Apparently healthy age-matched women of the hospital staff at various stage of the menstrual cycle.
  
  
  METHODS
  Twenty-five women involved in a IVF-ET program at the Department of Obstetrics and Gynecology, Montpellier University Hospital.
  
  
  METHODS
  Twenty-six hemostasis parameters evaluated repeatedly in patients undergoing IVF-ET.
  
  
  METHODS
  Blood cell-dependent hemostasis parameters and plasmatic coagulation factors, determined at pituitary desensitization, maximal E2 level, and P plateau.
  
  
  RESULTS
  Activation of the hemostatic system is evidenced at the P plateau, when D-dimers and fragments 1 + 2 of the prothrombin levels rose dramatically. At E2 peak, no significant modification of hemostasis markers was noted.
  
  
  CONCLUSIONS
  The present results indicate that ovarian hyperstimulation may induce hemostasis activation at the P plateau. The role of supraphysiologic sex hormone levels on the hemostatic system requires further investigation.
authors.affiliation: University Hospital, Montpellier, France.
authors.forename: C
authors.initials: C
authors.lastname: Biron
authors.forename: F
authors.initials: F
authors.lastname: Galtier-Dereure
authors.forename: H
authors.initials: H
authors.lastname: Rabesandratana
authors.forename: I
authors.initials: I
authors.lastname: Bernard
authors.forename: P
authors.initials: P
authors.lastname: Aguilar-Martinez
authors.forename: J F
authors.initials: JF
authors.lastname: Schved
authors.forename: B
authors.initials: B
authors.lastname: Hedon
mesh_terms: D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D006487:Hemostasis; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000097:blood*; D011446:Prospective Studies; D016897:Respiratory Burst; D013925:Thromboplastin / Q000032:analysis
chemical_list: D004958:Estradiol; D013925:Thromboplastin