title: Psoriasis of the nails associated with disability in a large number of patients: results of a recent interview with 1,728 patients.
abstract: OBJECTIVE
  Occurrence rates of clinical features of nail psoriasis vary considerably in the literature. Little information is available on subjective complaints of patients affected by psoriasis of the nails.
  
  
  METHODS
  Interviews with 1,728 psoriatic patients concerning their nail changes and complaints are reviewed.
  
  
  RESULTS
  The results indicate that pitting and deformation are the most common clinical aberrations in psoriatic nails, with a positive association between the duration of skin lesions and nail psoriasis. No relation was found between age and nail psoriasis in this group. Remarkably, 51.8% of patients suffered from pain-caused by the nail changes, and a large group of patients was restricted in their daily activities, housekeeping and/or profession (58.9, 56.1, 47.9%). Treatment was disappointing: only 19.3% showed marked improvement during treatment.
  
  
  CONCLUSIONS
  This indicates that psoriasis of the nails is a more important individual and social-economic problem than previously assumed and that development of new treatments is needed.
authors.affiliation: Department of Dermatology, University Hospital Nijmegen, The Netherlands.
authors.forename: E M
authors.initials: EM
authors.lastname: de Jong
authors.forename: B A
authors.initials: BA
authors.lastname: Seegers
authors.forename: M K
authors.initials: MK
authors.lastname: Gulinck
authors.forename: J B
authors.initials: JB
authors.lastname: Boezeman
authors.forename: P C
authors.initials: PC
authors.lastname: van de Kerkhof
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D006233:Persons with Disabilities; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009262:Nails; D009426:Netherlands / Q000453:epidemiology; D011379:Prognosis; D011565:Psoriasis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000503:physiopathology; D011788:Quality of Life; D012044:Regression Analysis; D012307:Risk Factors; D017678:Sex Distribution; D011795:Surveys and Questionnaires