title: Inability of serum myocyte death markers to predict acute cardiac allograft rejection.
abstract: Acute cardiac rejection involves myocyte necrosis. Hence, markers of myocyte death may be useful in diagnosing rejection. Creatine kinase MB, MB isoforms, and troponins I and T were measured in 186 patients undergoing 365 endomyocardial biopsies. No differences were noted with rejection (rejectors vs. nonrejectors: CK=63.8 U/L and 86.6 U/L, P=0.0881; CK MB=2.04 ng/ml and 2.06 ng/ml, P=0.949; troponin T=0.134 ng/ml and 0.0881 ng/ml, P=0.374; troponin I=0.216 ng/ml and 0.707 ng/ml, P=0.357). The time course of troponins T and I levels in rejectors and nonrejectors do not differ with both groups having early elevations. Markers of myocyte death are inadequate predictors of acute rejection in cardiac allografts. The time course of troponins T and I suggests a possible role as prognostic indicators of outcome.
authors.affiliation: Department of Cardiology, The Cleveland Clinic Foundation, Ohio 44195, USA.
authors.forename: C W
authors.initials: CW
authors.lastname: Wang
authors.forename: S R
authors.initials: SR
authors.lastname: Steinhubl
authors.forename: W J
authors.initials: WJ
authors.lastname: Castellani
authors.forename: F
authors.initials: F
authors.lastname: Van Lente
authors.forename: D P
authors.initials: DP
authors.lastname: Miller
authors.forename: K B
authors.initials: KB
authors.lastname: James
authors.forename: J B
authors.initials: JB
authors.lastname: Young
mesh_terms: D000208:Acute Disease; D015415:Biomarkers / Q000097:blood; D016923:Cell Death / Q000187:drug effects; D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000097:blood*; D006084:Graft Rejection / Q000175:diagnosis*; D016027:Heart Transplantation / Q000276:immunology*; D006801:Humans; D007527:Isoenzymes; D009130:Muscle, Smooth / Q000166:cytology; D014336:Troponin / Q000097:blood; D019210:Troponin I / Q000097:blood; D020107:Troponin T
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; D014336:Troponin; D019210:Troponin I; D020107:Troponin T; D003402:Creatine Kinase