[Therapy of liver damage in sheep].
On the model of fasting metabolism in sheep we examined the effects of Prednisolon, Methionin, Heparemin, Glucose 200 and Alwesin: Prednisolon had the most lasting antilipolytic and liver protecting (bilirubin decreasing) action. Comparatively weaker antilipolytic, antiketogenic and liver protective effects were shown by Methionin and Heparemin. Glucose 200 also indicated a similar antiketogenic but less antilipolytic influence. The lysin-contained in Heparemin obviously displayed no additional effects on the fasting metabolism. During the fasting state neither Alwesin, an amino acid mixture, nor Heparemin in CCl4 intoxicated sheep induced positive pharmacological outcomes. Independent of the present investigations, it applies that the regulation of energy, protein and electrolyte metabolism is of up most importance in cases of liver damage.
Fürll
M
M
Medizinische Tierklinik, Veterinärmedizinischen Fakultät Leipzig.
D000596:Amino Acids; D000818:Animals; D005215:Fasting; D005527:Food, Fortified; D005947:Glucose; D008066:Lipolysis / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008107:Liver Diseases / Q000517:prevention & control / Q000628:therapy / Q000662:veterinary*; D008239:Lysine; D008715:Methionine / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D012756:Sheep; D012757:Sheep Diseases
D000596:Amino Acids; D011239:Prednisolone; D008715:Methionine; D005947:Glucose; D008239:Lysine