title: Irritancy testing in occupational dermatology: comparison between two quick tests and the acute irritation induced by sodium lauryl sulphate.
abstract: To reduce the incidence of irritant contact dermatitis, the development of screening methods to identify subjects with increased susceptibility to irritants is essential. In a pilot study on the comparison between two quick, non-invasive irritancy tests (dimethyl sulfoxide (DMSO) and sodium hydroxide (NaOH) with the time-consuming patch testing with sodium lauryl sulphate (SLS), no correlation between the "quick tests" and SLS patch testing was observed. In the present paper the results of irritancy testing in 181 metal worker trainees are presented. Experimental irritant contact dermatitis reactions were induced on the medial third of the volar forearm using SLS 0.5%, applied for 23 h and as "quick tests" DMSO 90% and 95% and a solution of 0.2% mol/l NaOH applied for 5 min. Assessment of skin irritability was made by visual scoring and measurement of transepidermal water loss. Except for a statistically significant relationship between the irritations by DMSO 90% and 95%, correlations between the different techniques were weak or non-existent. This is most probably due to different pathophysiological pathways for the irritant reactions. We therefore propose to use a spectrum of different tests in occupational dermatology for predicting the individual's risk of irritant contact dermatitis.
authors.affiliation: Department of Dermatology, University of Zurich, Switzerland.
authors.forename: E
authors.initials: E
authors.lastname: Bangha
authors.forename: U
authors.initials: U
authors.lastname: Hinnen
authors.forename: P
authors.initials: P
authors.lastname: Elsner
mesh_terms: D000293:Adolescent; D000328:Adult; D009783:Dermatitis, Occupational / Q000175:diagnosis*; D004121:Dimethyl Sulfoxide / Q000633:toxicity; D005260:Female; D006801:Humans; D007509:Irritants / Q000633:toxicity*; D008297:Male; D010328:Patch Tests; D010865:Pilot Projects; D012967:Sodium Dodecyl Sulfate / Q000633:toxicity*
chemical_list: D007509:Irritants; D012967:Sodium Dodecyl Sulfate; D004121:Dimethyl Sulfoxide