title: Genome research and evolution in trypanosomes.
abstract: Trypanosoma brucei and Trypanosoma cruzi cause different human diseases. As strategies for immune evasion, T. brucei undergone antigenic variation whereas T. cruzi becomes an intracellular organism. This fundamental difference is reflected by major differences in their genome organizations. Recent comparisons of their gene sequences indicate that these two trypanosome species are highly divergent evolutionarily.
authors.affiliation: Department of Biochemistry, University of Iowa, Iowa City, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Donelson
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D018503:Genome, Protozoan; D006801:Humans; D017393:RNA Editing; D016053:RNA, Protozoan; D014346:Trypanosoma brucei brucei / Q000235:genetics*; D014349:Trypanosoma cruzi / Q000235:genetics*
chemical_list: D016053:RNA, Protozoan