Phosphorus magnetic resonance spectroscopy in cluster headache.
We performed in vivo MR spectroscopy phosphorus (31P-MRS) on the brain and skeletal muscles of 14 patients affected with cluster headache (CH). We examined patients in interictal periods, and also examined nine of them during the cluster period, although not during the attack. Brain 31P-MRS showed reduced phosphocreatine (PCr) levels, an increased ADP concentration (calculated from the creatine kinase equilibrium), a reduced phosphorylation potential, and a high relative rate of ATP biosynthesis (V/Vmax %). The inorganic phosphate (P(i)) content was increased during the cluster period. Ten of 13 patients also showed a slow rate of PCr recovery in muscle after the exercise. 31P-MRS in CH patients showed abnormalities of brain and skeletal muscle energy metabolism comparable with those seen in various types of migraine, thus leading us to suggest a similarity in biochemical pathogenic mechanisms between CH and migraine.
Montagna
P
P
Institute of Clinical Neurology, University of Bologna, Italy.
Lodi
R
R
Cortelli
P
P
Pierangeli
G
G
Iotti
S
S
Cevoli
S
S
Zaniol
P
P
Barbiroli
B
B
D000244:Adenosine Diphosphate / Q000378:metabolism; D000328:Adult; D001921:Brain / Q000378:metabolism / Q000473:pathology; D003027:Cluster Headache / Q000175:diagnosis* / Q000378:metabolism; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology; D010725:Phosphocreatine / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D010766:Phosphorylation; D005082:Physical Exertion
D010725:Phosphocreatine; D010758:Phosphorus; D000244:Adenosine Diphosphate