title: [Determination of free PSA in 85 consecutive cases with increased total PSA].
abstract: With a view to a more clearcut discrimination between benign prostatic hyperplasia (BPH) and prostate cancer (PCA), an additional measurement of the free PSA serum concentration and its ratio to total PSA (f-PSA/t-PSA) were determined in sera from 85 consecutive ambulatory patients with a total PSA concentration exceeding 4 ng/ml. Results with a ratio higher than 0.16 correlated with a high probability of benign disease (BPH), while a ratio below 0.16 was less meaningful. Thus, testing of free PSA seems to contribute to reducing the number of unnecessary biopsies in patients with elevated PSA.
authors.affiliation: Medizinische Laboratorien Rothen, Basel.
authors.forename: J P
authors.initials: JP
authors.lastname: Rothen
authors.forename: R
authors.initials: R
authors.lastname: Vuillemin
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D017430:Prostate-Specific Antigen / Q000302:isolation & purification*; D011470:Prostatic Hyperplasia / Q000276:immunology*; D011471:Prostatic Neoplasms / Q000276:immunology*
chemical_list: D017430:Prostate-Specific Antigen