Ansamycin antibiotics as free radical scavengers isolated from Streptomyces by using the bactericidal action of the hydroxyl radical.
Ansamycin antibiotics (1-4) were isolated from the cultured broth of Streptomyces sp. USF-319 strain as a result of our screening for free radical scavengers. They inhibited the bactericidal effect of the Fenton reagent toward Bacillus subtilis by their radical scavenging activity. Some of them also showed inhibitory activity against lipid peroxidation and lipoxygenases.
Morimitsu
Y
Y
Laboratory of Applied Microbiology, School of Food and Nutritional Sciences, University of Shizuoka, Japan.
Hirota
A
A
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects*; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000494:pharmacology*; D017665:Hydroxyl Radical; D015227:Lipid Peroxidation / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D017828:Rifabutin / Q000302:isolation & purification / Q000494:pharmacology*; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D016166:Free Radical Scavengers; D017828:Rifabutin; D017665:Hydroxyl Radical