Glutaraldehyde as a fixative in bioprostheses and drug delivery matrices.
The use of glutaraldehyde as a fixative in bioprostheses and drug delivery matrices is reviewed. The chemistry of glutaraldehyde cross-linking and its effect on the biological performance of a number of bioprostheses such as tissue heart valves, vascular grafts, pericardial patches, tendon grafts and drug delivery matrices are examined.
Jayakrishnan
A
A
Polymer Chemistry Division, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
Jameela
S R
SR
D001696:Biomechanical Phenomena; D001705:Bioprosthesis / Q000592:standards*; D001807:Blood Vessel Prosthesis / Q000592:standards; D003432:Cross-Linking Reagents / Q000009:adverse effects / Q000737:chemistry* / Q000378:metabolism; D016503:Drug Delivery Systems / Q000592:standards*; D005404:Fixatives / Q000009:adverse effects / Q000737:chemistry* / Q000378:metabolism; D005976:Glutaral / Q000009:adverse effects / Q000737:chemistry* / Q000378:metabolism; D006350:Heart Valve Prosthesis / Q000592:standards; D006801:Humans; D007107:Immune System / Q000187:drug effects; D010496:Pericardium / Q000378:metabolism; D011108:Polymers
D003432:Cross-Linking Reagents; D005404:Fixatives; D011108:Polymers; D005976:Glutaral