title: Investigation of the anti-inflammatory activity of Acacia nilotica and Hibiscus sabdariffa.
abstract: The aqueous extracts of Acacia nilotica and Hibiscus sabdariffa were tested for anti-inflammatory, analgesic and antipyretic activities in animal models. Acacia nilotica extract had an inhibitory effect on carrageenan induced paw edema and yeast-induced pyrexia in rats. It also produced a significant increase in the hot plate reaction time in mice. Hibiscus sabdariffa extract had no effect on paw edema but had an inhibitory effect on yeast induced pyrexia and a significant effect on the hot plate reaction time. Among the phytoconstituents found in both plants, flavanoids, polysaccharides and organic acids may be mainly responsible for their pharmacological activities.
authors.affiliation: Department of Biochemistry, College of Medicine and Medical Sciences, King Faisal University, Dammam, Saudi Arabia.
authors.forename: A A
authors.initials: AA
authors.lastname: Dafallah
authors.forename: Z
authors.initials: Z
authors.lastname: al-Mustafa
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D016488:Medicine, African Traditional; D051379:Mice; D010146:Pain / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects*