The dynamic interplay of malignant and benign T cells in cutaneous T-cell lymphoma.
Cutaneous T-cell lymphoma is a malignancy of functional, tissue-specific T cells. Many characteristics of the disease can be explained by virtue of the ability of the malignant cell population to actively participate in the host's immunologic network. Various aspects of this dynamic interplay between malignant and benign T cells are discussed, including impact on diagnosis, staging, and therapy.
Herrick
C
C
Dermatology Department, Yale University School of Medicine, New Haven, Connecticut, USA.
Heald
P
P
D003937:Diagnosis, Differential; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D015996:Survival Rate; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*