Anogenital papillomavirus infection and neoplasia in immunodeficient women.
This article reviews the impact of infection with human immunodeficiency virus (HIV) on HPV infections and HPV-associated lesions of the female anogenital tract. Studies investigating HPV infections in HIV-seropositive women are presented as well as the possibility that HIV can influence HPV expression directly through molecular interactions between viral genes and indirectly through immunosuppression. Studies linking HIV infection to invasive cervical cancer and cervical intraepithelial neoplasia are reviewed; recommended protocols for cervical cancer screening in HIV-seropositive women for cervical disease also are presented.
Wright
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Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York, USA.
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XW
D000293:Adolescent; D000328:Adult; D005260:Female; D014943:Global Health; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D016867:Immunocompromised Host; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000276:immunology; D012307:Risk Factors; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000276:immunology; D014481:United States / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000276:immunology / Q000517:prevention & control; D002578:Uterine Cervical Dysplasia / Q000150:complications / Q000276:immunology / Q000517:prevention & control