title: Multiple-dose pharmacokinetics of cefpirome in long-term hemodialysis with high-flux membranes.
abstract: Cefpirome is a cephalosporin eliminated primarily by kidneys that requires dosage reduction in patients with renal failure. The pharmacokinetic parameters were studied in 10 patients with end-stage renal disease who were receiving hemodialysis. Repeated intravenous administration of 2 gm cefpirome three times a week resulted in trough levels of 12.2 +/- 5.4 micrograms/ml and peak serum concentrations of 99.6 +/- 82.1 micrograms/ml. After 3 1/2 hours of hemodialysis with polysulfone high-flux membranes, 62.3% +/- 23.3% of cefpirome was removed. The interdialytic half-life was 9.35 +/- 0.99 hours, and the intradialytic half-life was 2.02 +/- 0.7 hours.
authors.affiliation: Department of Infectious Diseases, University of Vienna, Austria.
authors.forename: F
authors.initials: F
authors.lastname: Thalhammer
authors.forename: S
authors.initials: S
authors.lastname: Schmaldienst
authors.forename: I
authors.initials: I
authors.lastname: Elmenyawi
authors.forename: M
authors.initials: M
authors.lastname: Atteneder
authors.forename: H
authors.initials: H
authors.lastname: Burgmann
authors.forename: U
authors.initials: U
authors.lastname: Hollenstein
authors.forename: A
authors.initials: A
authors.lastname: Georgopoulos
authors.forename: W
authors.initials: W
authors.lastname: Graninger
authors.forename: D
authors.initials: D
authors.lastname: Putz
authors.forename: A R
authors.initials: AR
authors.lastname: Rosenkranz
authors.forename: G
authors.initials: G
authors.lastname: Mayer
authors.forename: W H
authors.initials: WH
authors.lastname: Hörl
authors.forename: S
authors.initials: S
authors.lastname: Breyer
mesh_terms: D000328:Adult; D000368:Aged; D002511:Cephalosporins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007676:Kidney Failure, Chronic / Q000628:therapy; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D011108:Polymers; D006435:Renal Dialysis / Q000379:methods*; D013450:Sulfones; D000097572:Cefpirome
chemical_list: D002511:Cephalosporins; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; D000097572:Cefpirome; C017662:polysulfone P 1700