title: Ultraviolet B stimulates production of corticotropin releasing factor (CRF) by human melanocytes.
abstract: Here we show that human melanocytes express the corticotropin releasing factor (CRF) gene and produce CRF peptide. The CRF production and secretion is markedly stimulated by ultraviolet B (UVB) radiation. This is the first demonstration that cutaneous melanocytes respond to environmental stress (UVB) through the production of CRF.
authors.affiliation: Department of Pathology and Laboratory Medicine, Albany Medical College, NY 12208, USA. andrzej_slominski@ccgateway.amc.edu
authors.forename: A
authors.initials: A
authors.lastname: Slominski
authors.forename: J
authors.initials: J
authors.lastname: Baker
authors.forename: G
authors.initials: G
authors.lastname: Ermak
authors.forename: A
authors.initials: A
authors.lastname: Chakraborty
authors.forename: J
authors.initials: J
authors.lastname: Pawelek
mesh_terms: D002478:Cells, Cultured; D003346:Corticotropin-Releasing Hormone / Q000096:biosynthesis* / Q000235:genetics; D005786:Gene Expression Regulation / Q000528:radiation effects; D006801:Humans; D008544:Melanocytes / Q000378:metabolism / Q000528:radiation effects*; D012333:RNA, Messenger / Q000235:genetics; D014466:Ultraviolet Rays
chemical_list: D012333:RNA, Messenger; D003346:Corticotropin-Releasing Hormone