title: The airways and anaesthesia II. Pathophysiology.
abstract: We pointed out in the first of these two articles that the commonest cause of an anaesthetic disaster in young healthy patients is a loss of airway patency then a failure to intubate occurring unexpectedly in the absence of head or neck pathology. Upper airway obstruction is a very common complication of general anaesthesia and all anaesthetists must be trained in the management of this problem. Less obvious are the changes that can occur in the lower airways which can impair gas exchange by increasing ventilation-perfusion mismatch. This article is concerned with these pathophysiological changes that occur during general anaesthesia.
authors.affiliation: University Department of Anaesthesia, Addenbrooke's Hospital, Cambridge.
authors.forename: D R
authors.initials: DR
authors.lastname: Burwell
authors.forename: J G
authors.initials: JG
authors.lastname: Jones
mesh_terms: D000402:Airway Obstruction / Q000139:chemically induced; D000768:Anesthesia, General / Q000009:adverse effects*; D018681:Anesthetics, General / Q000009:adverse effects; D001980:Bronchi / Q000187:drug effects; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy; D001261:Pulmonary Atelectasis / Q000139:chemically induced; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D012018:Reflex / Q000187:drug effects; D012120:Respiration Disorders / Q000139:chemically induced* / Q000503:physiopathology; D012137:Respiratory System / Q000503:physiopathology
chemical_list: D018681:Anesthetics, General