title: Reduction of propofol pain--fentanyl vs lidocaine.
abstract: To compare the local efficacy of lidocaine and fentanyl in reducing propofol injection pain (PIP), we conducted a prospective randomized double-blind study in 75 ASA I and II adult patients. When administered 20 seconds before propofol with a venous tourniquet, lidocaine but not fentanyl or placebo, reduced the incidence of moderate to severe pain on subsequent injection of propofol (P < 0.001). Two patients (8%) in the lidocaine group (n = 25) experienced a moderate degree of pain and none experienced severe pain. Fifteen (60%) in the fentanyl group (n = 25) experienced moderate or severe degrees of pain, compared with 15 (60%) in the saline group (n = 25). We conclude that lidocaine, acting locally, reduce propofol injection pain while fentanyl does not.
authors.affiliation: Department of Anesthesia, National Guard King Khalid Hospital, Jeddah, Saudi Arabia.
authors.forename: W A
authors.initials: WA
authors.lastname: Alyafi
authors.forename: J
authors.initials: J
authors.lastname: Rangasami
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D000779:Anesthetics, Local / Q000627:therapeutic use*; D005260:Female; D005283:Fentanyl / Q000627:therapeutic use*; D006801:Humans; D007275:Injections, Intravenous / Q000009:adverse effects; D008012:Lidocaine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000517:prevention & control*; D015742:Propofol / Q000009:adverse effects*; D011446:Prospective Studies
chemical_list: D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D008012:Lidocaine; D005283:Fentanyl; D015742:Propofol