Halicylindramides D and E, antifungal peptides from the marine sponge Halichondria cylindrata.
Halicylindramides D (1) and E (2) have been isolated from the marine sponge Halichondria cylindrata. Halicylindramide D is a tridecapeptide with the N-terminus blocked by a formyl group and the C-terminus lactonized with a threonine residue, while halicylindramide E is a truncated linear peptide with a C-terminal amide. Their structures, including absolute stereochemistry, were determined by a combination of spectral and chemical methods. Halicylindramide D was antifungal against Mortierella ramanniana and cytotoxic against P-388 murine leukemia cells.
Li
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Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agriculture, University of Tokyo, Japan.
Matsunaga
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S
Fusetani
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N
D000595:Amino Acid Sequence; D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology* / Q000633:toxicity; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D006868:Hydrolysis; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009090:Mucorales / Q000187:drug effects; D009842:Oligopeptides / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D009842:Oligopeptides; C102773:halicylindramide D; C102774:halicylindramide E