[Leptospirosis: a cause of pseudo-malarial fever in Gabon].
A first case of leptospirosis has been recently described in Gabon where bioclimatological characteristics could favour the transmission of that disease. Therefore, a search for antibodies to leptospirae was conducted among 55 military Frenchmen with unexplained fever during a four-month stay in Gabon. Three (5.5%) were positive with IgM levels attesting for recent contamination. A screening antigenic battery identified L. bataviae in two cases and L. sejroe in one case. The three patients were employed outside in the precedent weeks. Travelers are exposed to leptospirosis in numerous Third-World countries. Clinical and biological similarities between leptospirosis and P. falciparum malaria could induce misdiagnosis. Co-infection could also be encountered. Doxycycline, whose activity against P. falciparum is well known, is also effective against leptospirae. Therefore, this drug seems valuable for prophylactic and therapeutic actions in areas exposed to the both diseases.
Perret
J L
JL
Service de médecine interne et pathologie infectieuse et tropicale, HIA Laveran, Marseille-Armées.
Velasque
L
L
Morillon
M
M
Martet
G
G
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D003937:Diagnosis, Differential; D005334:Fever; D005602:France / Q000208:ethnology; D005681:Gabon; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007919:Leptospira / Q000276:immunology; D007922:Leptospirosis / Q000175:diagnosis* / Q000276:immunology; D016778:Malaria, Falciparum; D008297:Male; D008889:Military Personnel
D000907:Antibodies, Bacterial; D007075:Immunoglobulin M