[Follow up control of stage IV neuroblastoma: 123I-MIBG scintigraphy, bone scintigraphy and catecholamine metabolites].
OBJECTIVE
The diagnostic value of 123I-mIBG-scintigraphy, bone scintigraphy and catecholamine metabolites in the follow up of neuroblastoma stage IV will be evaluated.


METHODS
Nineteen children suffering from neuroblastoma were analysed retrospectively by 123I-mIBG-scintigraphy, bone scintigraphy and measurement of homovanillic acid, vanillic acid, neuronspecific enclose, lactate dehydrogenase, and ferritine. Follow up was 7-132 (median 36) months.


CONCLUSIONS
The significance of the methods was dependent on the time of diagnostic use. In principal, 123I-mIBG-scintigraphy has the highest diagnostic impact. For initial staging and diagnosis of recurrence a combination of all three methods can be used. On the contrary, follow up during chemotherapy is best documented by 123I-mIBG-scintigraphy, whereas bone scintigraphy is of limited and measurement of catecholamine metabolites of less diagnostic value.
Kohnert
K
K
Klinik und Poliklinik für Nuklcarmedizin, Westfälische Wilhelms-Universität Münster, Deutschland.
Lerch
H
H
Thelen
M
M
Jürgens
H
H
Schober
O
O
D019797:3-Iodobenzylguanidine; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D001932:Brain Neoplasms / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D002395:Catecholamines / Q000097:blood* / Q000652:urine; D002648:Child; D002675:Child, Preschool; D005293:Ferritins / Q000097:blood / Q000652:urine; D005500:Follow-Up Studies; D006719:Homovanillic Acid / Q000097:blood / Q000652:urine; D006801:Humans; D007223:Infant; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000652:urine; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D010751:Phosphopyruvate Hydratase / Q000097:blood / Q000652:urine; D011877:Radionuclide Imaging; D012008:Recurrence; D012189:Retrospective Studies; D013997:Time Factors; D014641:Vanillic Acid / Q000097:blood / Q000652:urine
D002395:Catecholamines; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine; D005293:Ferritins; D007770:L-Lactate Dehydrogenase; D010751:Phosphopyruvate Hydratase; D014641:Vanillic Acid; D006719:Homovanillic Acid