title: Remission of advanced uterine leiomyosarcoma with pulmonary metastases with carboplatin and paclitaxel.
abstract: A patient who had a high-grade uterine leiomyosarcoma (LMS) with extensive intra-abdominal and pulmonary metastases at the time of diagnosis underwent supracervical hysterectomy, bilateral salpingo-oophorectomy and tumor reductive surgery. She then received induction chemotherapy with paclitaxel 135 mg/m2 over 24 h and carboplatin (target AUC = 7.5 mg.ml/min) monthly for seven courses, achieving remission with a small amount of residual disease. The treatment was well tolerated except for peripheral neuropathy. Accordingly, the combination of carboplatin and paclitaxel may be considered in patients with advanced high-grade LMS of the uterus, and this regimen warrants further study in this disease.
authors.affiliation: University of Texas MD Anderson Cancer Center, Houston 77030, USA.
authors.forename: A P
authors.initials: AP
authors.lastname: Kudelka
authors.forename: W
authors.initials: W
authors.lastname: Termrungruanglert
authors.forename: S
authors.initials: S
authors.lastname: Vadhan-Raj
authors.forename: C L
authors.initials: CL
authors.lastname: Edwards
authors.forename: D G
authors.initials: DG
authors.lastname: Varma
authors.forename: C
authors.initials: C
authors.lastname: Tornos
authors.forename: C F
authors.initials: CF
authors.lastname: Verschraegen
authors.forename: J J
authors.initials: JJ
authors.lastname: Kavanagh
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D016190:Carboplatin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D017239:Paclitaxel / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D016190:Carboplatin; D017239:Paclitaxel