Immunohistochemical localization of apolipoprotein E in renal amyloidosis.
To clarify the role of apolipoprotein E (apo E) in the formation of amyloid deposits, we examined specimens from 11 patients with renal amyloidosis who underwent renal biopsy by an immunohistochemical method using a monoclonal antibody (murine IgG1). Apo E was distributed in the amyloid deposits of all patients in a pattern similar to that obtained with Congo red staining. Strong positive staining for apo E was found on the amyloid deposits in the glomeruli. These results suggest that apo E is a common constituent of amyloid fibrils and that it may be a useful marker for immunohistochemical studies of systemic amyloidosis including renal amyloidosis.
Taniguchi
Y
Y
Second Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Yorioka
N
N
Yamashita
K
K
Oda
H
H
Nie
L F
LF
Ye Yeu
X F
XF
Okushin
S
S
Nishida
Y
Y
Kushihata
S
S
Yamakido
M
M
D000328:Adult; D000686:Amyloidosis; D001057:Apolipoproteins E / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000737:chemistry*; D007674:Kidney Diseases; D008297:Male; D008875:Middle Aged
D001057:Apolipoproteins E