Maxillary malignant mesenchymoma and massive fibrous dysplasia.
This is the first report (to our knowledge) that describes a patient with massive polyostotic fibrous dysplasia involving the calvaria and facial skeleton that subsequently underwent transformation to a malignant mesenchymoma with elements of chondrosarcoma, osteosarcoma, and rhabdomyosarcoma arising in the maxilla. Malignant transformation occurred in the absence of prior radiation exposure, osteomyelitis, or known bony infarction. A review of the literature did not reveal any similar cases of massive fibrous dysplasia of the maxilla degenerating to multiple simultaneous malignant histotypes.
Beuerlein
M E
ME
Comprehensive Cancer Center Head and Neck Oncology Program, Arthur G. James Cancer Hospital and Research Institute, Ohio State University, Columbus, USA.
Schuller
D E
DE
DeYoung
B R
BR
D000328:Adult; D005147:Facial Bones; D005359:Fibrous Dysplasia, Polyostotic / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D008441:Maxillary Neoplasms / Q000209:etiology* / Q000473:pathology; D008637:Mesenchymoma / Q000209:etiology* / Q000473:pathology