Effect of the milk extract of Semecarpus anacardium nut on adjuvant arthritis--a dose-dependent study in Wistar albino rats.
1. Adjuvant-induced arthritis in rats is used as a pathologic model for chronic inflammatory disease to evaluate the efficacy of therapeutic agents. 2. In the present work, attempts have been made to study the potency of a milk extract of Semecarpus anacardium (Serankottai Nei), a Siddha preparation from Semecarpus anacardium nut, which has been shown to have antiarthritic effects. 3. Experimental arthritis induces a significant modification in lysosomal enzyme release and total carbohydrate components of glycoprotein. 4. Milk extract was administered at the dose level of 50, 100, 150, 200, and 250 mg/kg body weight in olive oil orally (volume 0.5 ml) after 14 days from the day of adjuvant injection. 5. After administration of the extract the lysosomal enzyme activity and protein-bound carbohydrate component levels were significantly normalized. 6. The data obtained clearly indicate that the Semecarpus anacardium is effective at the dose level of 150 mg/kg body weight in adjuvant-induced arthritis in albino Wistar rats.
Vijayalakshmi
T
T
Department of Medical Biochemistry, University of Madras, India.
Muthulakshmi
V
V
Sachdanandam
P
P
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000473:pathology; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005966:Glucuronidase / Q000378:metabolism; D006023:Glycoproteins / Q000097:blood; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006023:Glycoproteins; D010936:Plant Extracts; D005966:Glucuronidase