Structure-function analysis of the cloned opiate receptors: peptide and small molecule interactions.
Opiate receptors mediate the physiological actions of opioid peptides and the clinical effects of the synthetic opioid agonists and antagonists. Site-directed mutagenesis studies have revealed regions of opiate receptors that are essential for ligand recognition, and this could aid the design of more selective opioid ligands.
Blake
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Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
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Reisine
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D001665:Binding Sites; D003001:Cloning, Molecular; D008958:Models, Molecular; D015394:Molecular Structure; D009292:Narcotic Antagonists; D010455:Peptides / Q000378:metabolism*; D011957:Receptors, Opioid / Q000819:agonists / Q000378:metabolism*; D013329:Structure-Activity Relationship
D009292:Narcotic Antagonists; D010455:Peptides; D011957:Receptors, Opioid