Carbamazepine and PIP-syndrome in temporal lobe epilepsy.
We describe four patients with left temporal lobe epilepsy who developed psychosis, intermittent polydipsia and hyponatremia (PIP-syndrome) while being treated with carbamazepine. These cases illustrate the close links between dysfunction of the limbic system causing epileptic seizures and psychosis on the one hand and dysregulation in hypothalamic centers manifestating in polydipsia and osmodysregulation on the other.
Schmitz
B
B
Psychiatrische Klinik und Poliklinik, Klinikum Benjamin Franklin, Berlin, Germany.
Trimble
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MR
D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects*; D002771:Cholera / Q000150:complications; D006259:Craniocerebral Trauma / Q000150:complications; D004327:Drinking Behavior / Q000187:drug effects*; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced*; D008288:Malaria / Q000150:complications; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D014882:Water-Electrolyte Balance / Q000187:drug effects
D000927:Anticonvulsants; D002220:Carbamazepine