[The antitumor action of antibiotics produced by Streptomyces globisporus 1912 studied in a model of Guérin's carcinoma in rats].
Streptomyces globisporus 1912 produces anthracycline-like antibiotics inhibiting the growth of gram-positive bacteria. 6-7 compounds can be separated from crude culture extract by means of thin-layer chromatography. The compound with Rf 0.33 can act as the antitumor antibiotic against Guérin carcinoma of rats.
Polishchuk
L V
LV
Hanusevych
I I
II
Matseliukh
B P
BP
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000302:isolation & purification / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D009368:Neoplasm Transplantation; D051381:Rats; D012074:Remission Induction; D013302:Streptomyces / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic