title: A complex satellite DNA polymorphism flanking the human ryanodine receptor gene (RYR1).
abstract: We describe a new highly polymorphic DNA marker flanking the human ryanodine receptor gene (RYR1) at chromosome band 19q13.1. The marker is composed of a 25bp minisatellite sequence, a compound microsatellite (AC)(AT), and an oligo-T stretch. STS mapping of previously published markers from 19q13.1 helped to integrate the genetic and physical maps of this region. Together with D19S422, the new polymorphism forms a pair of markers closely flanking either side of the RYR1 gene which may be useful for linkage studies in families susceptible to malignant hyperthermia and central core disease.
authors.affiliation: Institute of Human Genetics, University of Würzburg, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Wolz
authors.forename: U
authors.initials: U
authors.lastname: Wendelmuth
authors.forename: S
authors.initials: S
authors.lastname: Rouquier
authors.forename: D
authors.initials: D
authors.lastname: Giorgi
authors.forename: C R
authors.initials: CR
authors.lastname: Müller
mesh_terms: D001483:Base Sequence; D015220:Calcium Channels / Q000235:genetics*; D004276:DNA, Satellite / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009124:Muscle Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D019837:Ryanodine Receptor Calcium Release Channel
chemical_list: D015220:Calcium Channels; D004276:DNA, Satellite; D009124:Muscle Proteins; D019837:Ryanodine Receptor Calcium Release Channel