[The histogenesis of embryonic neocortical allografts in rats under the action of cyclosporine A].
By means of morphological methods, a study was made of effects of cyclosporin A (Cs A) on developmental dynamics in 15 day old embryo neocortex transplanted into the rat brain. It is shown that Cs A exerts no cytotoxic or cytostatic effects on grafting cells. Differentiation of grafting neuroepithelial cells into neuroblasts, young neurons and neurons in transplants of Cs A-treated rats and control transplants took place at the same time. Mitotic activity of grafting neuroepithelial cells was lower than in developing neocortex in situ; pathological mitotic forms have been described.
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D000818:Animals; D016380:Brain Tissue Transplantation / Q000379:methods / Q000473:pathology*; D002540:Cerebral Cortex / Q000196:embryology* / Q000637:transplantation* / Q000648:ultrastructure; D016572:Cyclosporine / Q000494:pharmacology*; D005260:Female; D016332:Fetal Tissue Transplantation / Q000379:methods / Q000473:pathology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008297:Male; D008854:Microscopy, Electron; D009024:Morphogenesis / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D016572:Cyclosporine