[Introduction of definite molecular weight heparan sulfate in a protocol of prevention of deep venous thrombosis in prosthetic orthopedic surgery].
Use of definite molecular weight heparan sulphate in a protocol for the prevention of deep venous thrombosis in the total joint replacement surgery. The authors propose a working protocol for the prevention of deep venous thrombosis in prosthetic orthopaedic surgery. It requires that integration of pharmacological, anaesthesiological, rheological and physiokinesitherapic measures, it has permitted a very good prevention of thromboembolic disease and it is well-tolerated and safe. The protocol requires: peripheral anaesthesia (sub-arachnoidal block), pre and post-operative pharmacological treatment with heparan-sulphate of a fixed molecular weight, haemodilution with maintenance of the haematocrit at no more than 30%, early physiokinesitherapy associated with the use of elastic stockings graduated tension. The fifty patients treated with this protocol were controlled during the pre-operative and post-operative stage and one month later and no thrombo-embolic complications resulted.
Mandò
M
M
UO Anestesia e Rianimazione, USL 8-Zona Valdarno Montevarchi (Arezzo).
Margiacchi
G P
GP
Alioto
R
R
Ferri
L
L
Bernardoni
F
F
Alberti
G
G
Teti
A
A
Simone
L D
LD
Bardelli
M
M
D000368:Aged; D001458:Bandages; D005081:Exercise Therapy; D005260:Female; D006497:Heparan Sulfate / Q000627:therapeutic use*; D006622:Hip Prosthesis; D006801:Humans; D007720:Knee Prosthesis; D008297:Male; D008970:Molecular Weight; D011183:Postoperative Complications / Q000517:prevention & control*; D013924:Thrombophlebitis / Q000517:prevention & control*
D006497:Heparan Sulfate