title: An immunohistochemical analysis of T-cell subsets in the chicken bursa of Fabricius during postnatal stages of development.
abstract: T-cell subsets in the chicken bursa of Fabricius were analysed immunohistochemically during postnatal stages. Distinct types of T cells were present both in the surface epithelium and lamina propria of the bursa. TcR1+ and CT8+ cells were predominant in the surface epithelium, while TcR2+ and CT8+ cells were numerous in the lamina propria. These T-cell subsets peaked in frequency of occurrence at 5 weeks. They then decreased in number, and a few T cells remained in the bursa until 15 weeks of age. This result showed that the bursa of chickens is furnished with the distinct types of T-cell subsets at early postnatal stages of development to maintain its local immunity.
authors.affiliation: Department of Biomedical Science, Postgraduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
authors.forename: M Z
authors.initials: MZ
authors.lastname: Khan
authors.forename: Y
authors.initials: Y
authors.lastname: Hashimoto
mesh_terms: D000375:Aging / Q000276:immunology*; D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D002060:Bursa of Fabricius / Q000254:growth & development / Q000276:immunology*; D002645:Chickens; D007150:Immunohistochemistry; D011948:Receptors, Antigen, T-Cell / Q000032:analysis; D012016:Reference Values; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D011948:Receptors, Antigen, T-Cell