[The effect of chemical sympathectomy on the adrenergic innervation of the blood vessels belonging to different organs in salt-sensitive and salt-resistant Dahl-strain rats].
The action of chemical desympathization by 6-hydroxydophamine influencing adrenergic innervation in different organs vessels (mesenterial, renal and femoral) was studied using histochemical fluorescent method in salt susceptible and salt-resistant Dahl rats kept on a low- and high-salt diet. Heterogeneity of adrenergic innervation of different region vessels was established to display and 6-hydroxydophamine caused complete desympathization only in mesenterial artery and in all veins, while in renal artery retained adrenergic plexus its certain branching and femoral artery-in two thirds of its surface. The process of reinnervation in vessels running with different intensity in different animals and in different vessels was found to start in vessels of majority of animals on day 5-6 after the chemical desympathization. 6-hydroxydophamine had greater impact on the vessels of salt-susceptible high salt rat (hypertension) and salt-resistant high-salt-diet (normension) rats. Thus, the state of arterial and venous adrenergic apparatus in hypertension Dahl rats is determined not by the increased blood pressure itself but by the natrium metabolism disturbance.
Leont'eva
G R
GR
Zicha
J
J
Kunes
J
J
D000320:Adrenergic Fibers / Q000648:ultrastructure*; D000818:Animals; D001808:Blood Vessels / Q000294:innervation*; D006973:Hypertension / Q000473:pathology; D008297:Male; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage*; D013563:Sympathectomy, Chemical; D013565:Sympatholytics; D013997:Time Factors
D017673:Sodium Chloride, Dietary; D013565:Sympatholytics; D016627:Oxidopamine