title: Plasma levels of endothelin-1 and thrombomodulin in burn patients.
abstract: Plasma concentrations of endothelin-1 (ET-1) and thrombomodulin (TM) were determined in patients with burns to examine their relation to the severity of illness. Tumor necrosis factor-alpha (TNF-alpha) was also measured, and its relationship to ET-1 and TM determined. Twenty-three burn patients were evaluated, who had a total burn surface area (TBSA) of at least 20 per cent. ET-1 was measured by radioimmunoassay (RIA). TM and TNF-alpha were measured by enzyme-linked immunosorbent assay (ELISA). Both the ET-1 and TM concentrations were significantly higher in the patients who developed sepsis than in those who did not and in the patients who eventually died than in those who survived. Maximum plasma concentrations of ET-1 and TM were significantly correlated with the acute physiological and chronic health evaluation II score. There was also a significant correlation between the plasma levels of TNF-alpha and both ET-1 and TM. ET-1 and TM closely reflect the severity of illness in patients with burns in the infectious stage; TNF-alpha may be involved in the production of ET-1 and TM.
authors.affiliation: Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakae
authors.forename: S
authors.initials: S
authors.lastname: Endo
authors.forename: K
authors.initials: K
authors.lastname: Inada
authors.forename: Y
authors.initials: Y
authors.lastname: Yamada
authors.forename: T
authors.initials: T
authors.lastname: Takakuwa
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
mesh_terms: D018806:APACHE; D000328:Adult; D000368:Aged; D001830:Body Surface Area; D002056:Burns / Q000097:blood* / Q000145:classification / Q000150:complications / Q000473:pathology; D019332:Endothelin-1 / Q000096:biosynthesis / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D018805:Sepsis / Q000097:blood / Q000150:complications; D012720:Severity of Illness Index; D015996:Survival Rate; D018180:Thrombomodulin / Q000096:biosynthesis / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000502:physiology; D014946:Wound Infection / Q000097:blood / Q000150:complications
chemical_list: D019332:Endothelin-1; D018180:Thrombomodulin; D014409:Tumor Necrosis Factor-alpha