title: Prenatal diagnosis of ring chromosome 14 after intracytoplasmic sperm injection.
abstract: OBJECTIVE
  To collect extensively abnormal cytogenetic results in pregnancies obtained after intracytoplasmic sperm injection (ICSI).
  
  
  METHODS
  Case report.
  
  
  METHODS
  University Hospital of Nantes, France.
  
  
  METHODS
  A couple with 5 years of primary infertility and severe male factor undergoing ICSI procedure.
  
  
  METHODS
  Ultrasound-guided transvaginal follicular aspiration, amniocentesis, and medical abortion.
  
  
  METHODS
  Serum levels of E2, beta-hCG, and fetal chromosomal karyotype.
  
  
  RESULTS
  Ultrasonic observation at 12 weeks revealed an 8-mm thick cystic hygroma in the nuchal area. Because the karyotypic analysis was [46,XX,r(14)/45,XX,-14], medical abortion was performed at 14 weeks, after the patients gave their informed consent.
  
  
  CONCLUSIONS
  According to the prevalence of this unusual chromosomal abnormality in humans, such abnormal cytogenetic results have to be collected extensively to assess the feasibility of using ICSI procedure.
authors.affiliation: Laboratoire de Biologie de la Reproduction, Centre Hospitalier Universitaire, Nantes, France.
authors.forename: M
authors.initials: M
authors.lastname: Jean
authors.forename: J M
authors.initials: JM
authors.lastname: Rival
authors.forename: A
authors.initials: A
authors.lastname: Mensier
authors.forename: S
authors.initials: S
authors.lastname: Mirallié
authors.forename: P
authors.initials: P
authors.lastname: Lopes
authors.forename: P
authors.initials: P
authors.lastname: Barrière
mesh_terms: D000328:Adult; D002883:Chromosomes, Human, Pair 14; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012303:Ring Chromosomes