Analysis of the candidate gene NRAMP1 in the first 61 ARC National Repository families for rheumatoid arthritis.
Maximum likelihood identity-by-descent (IBD) sib pair analysis using a 3 locus haplotype NRAMP1-IL8RB-VIL1, or NRAMP1 alone, provided preliminary evidence (maximum LOD score = 1.01, p = 0.024) for a gene in this region of human chromosome 2q35 contributing to susceptibility to rheumatoid arthritis (RA). Candidacy for NRAMP1 as the disease susceptibility gene was supported by a significant bias (p < 0.048) toward transmission of the NRAMP1 promoter region allele 3 in affected offspring.
Shaw
M A
MA
Department of Medicine, University of Cambridge Clinical School, Addenbrooke's Hospital, UK.
Clayton
D
D
Blackwell
J M
JM
D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D027682:Cation Transport Proteins; D005260:Female; D005786:Gene Expression Regulation; D005796:Genes / Q000235:genetics; D006680:HLA Antigens / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D000099173:Natural Resistance-associated Macrophage Protein 1
D002352:Carrier Proteins; D027682:Cation Transport Proteins; D006680:HLA Antigens; D008565:Membrane Proteins; D000099173:Natural Resistance-associated Macrophage Protein 1