Urinary creatine as a potential marker of testicular damage: effect of vasectomy.
The concentrations of creatine in the rat testis are high compared to all other tissues except muscle. The total creatine content of the testis is also considerably greater than all organs examined except muscle. Vasectomised male rats were given 2-methoxyethanol or cadmium chloride at doses that caused testicular damage. In the vasectomised rats, testicular damage still resulted in significant creatinuria. This indicates the creatine reaches the urine at least partly via the blood stream and not via the vas deferens.
Draper
R P
RP
Toxicology Department, School of Pharmacy, London, UK.
Timbrell
J A
JA
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood / Q000652:urine; D019256:Cadmium Chloride / Q000008:administration & dosage / Q000633:toxicity; D002273:Carcinogens / Q000008:administration & dosage / Q000633:toxicity*; D003401:Creatine / Q000097:blood / Q000652:urine*; D003404:Creatinine / Q000097:blood / Q000652:urine; D005026:Ethylene Glycols / Q000008:administration & dosage / Q000633:toxicity; D006884:Hydroxybutyrate Dehydrogenase / Q000097:blood; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000633:toxicity*; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D011507:Proteinuria; D011863:Radioimmunoassay; D051381:Rats; D017207:Rats, Sprague-Dawley; D013737:Testis / Q000737:chemistry / Q000187:drug effects / Q000473:pathology*; D013739:Testosterone / Q000097:blood; D014649:Vas Deferens / Q000502:physiology; D014659:Vasectomy / Q000009:adverse effects*
D015415:Biomarkers; D002273:Carcinogens; D005026:Ethylene Glycols; D007166:Immunosuppressive Agents; D007527:Isoenzymes; D013739:Testosterone; D003404:Creatinine; D007770:L-Lactate Dehydrogenase; D006884:Hydroxybutyrate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; C005219:methyl cellosolve; D019256:Cadmium Chloride; D003401:Creatine