[Possibilities and prospects in gene therapy in cancer patients].
The many different oncological concepts of gene therapy can be classified into three major groups. These include immunopotentiation, compensation of oncogene and tumor suppressor gene alterations, and suicide gene strategies. Gene marker studies and the transfer of drug resistance genes to normal cells have also shown to be of some importance in oncology. Although there is no clear demonstration of the efficacy of gene therapy so far, it will most likely become part of the therapeutic armamentarium of oncologists within the next two to three decades.
Rochlitz
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CF
Abteilung für Onkologie, Kantonsspital Basel.
Herrmann
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R
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D017209:Apoptosis / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D004995:Ethics, Professional; D018014:Gene Transfer Techniques; D016147:Genes, Tumor Suppressor / Q000235:genetics; D005819:Genetic Markers; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000276:immunology / Q000628:therapy*
D000276:Adjuvants, Immunologic; D005819:Genetic Markers