title: Two fungal lanostane derivatives as phospholipase A2 inhibitors.
abstract: The hydroalcoholic extract of Poria cocos and two lanostane derivatives isolated from it, pachymic acid (1) and dehydrotumulosic acid (2), were active as inhibitors of phospholipase A2 from snake venom when a polarographic method was used. Dehydrotumulosic acid exhibited an IC50 of 0.845 mM. These two compounds are structurally related to certain triterpenoids from Ganoderma and Schinus that have previously been described as competitive inhibitors of phospholipase A2. These comprise a new group of natural potential antiinflammatory agents due to their interaction with that enzyme.
authors.affiliation: Departament de Farmacologia, Universitat de València, vda,. Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Cuélla
authors.forename: R M
authors.initials: RM
authors.lastname: Giner
authors.forename: M C
authors.initials: MC
authors.lastname: Recio
authors.forename: M J
authors.initials: MJ
authors.lastname: Just
authors.forename: S
authors.initials: S
authors.lastname: Máñez
authors.forename: J L
authors.initials: JL
authors.lastname: Ríos
mesh_terms: D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D011048:Polarography; D011124:Polyporaceae / Q000737:chemistry*; D012910:Snake Venoms / Q000201:enzymology; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D012910:Snake Venoms; D014315:Triterpenes; C102488:dehydrotumulosic acid; D010741:Phospholipases A; D054467:Phospholipases A2; C102487:pachymic acid