A new transmissible AIDS-like disease in mice induced by alloimmune stimuli.
The search for a suitable and reliable animal model for human AIDS that is easy to use on a large scale continues. Here we describe a new condition in mice that closely resembles human AIDS, namely, chronic lymphoproliferation with dramatic depletion of CD4-positive cells, progressive impairment of the immune responses, and Kaposi's sarcoma-like tumors or terminal B-lymphomas. The AIDS-like disease was primarily induced by mating BALB/c female mice to C57BL/6 males during a 1-year period (7-10 allogeneic pregnancies) followed by immunization with paternal lymphocytes. The disease is sexually and vertically transmissible, transferrable by cell-free plasma and is associated with autoimmune reactions to major histocompatibility complex antigens and CD4 cells. We hope that this becomes a model for studying the mechanisms of AIDS immunopathogenesis and immune-based treatment approaches.
Ter-Grigorov
V S
VS
Department of Immunology and Pathology, Kimron Veterinary Institute, Bet-Dagan, Israel.
Krifuks
O
O
Liubashevsky
E
E
Nyska
A
A
Trainin
Z
Z
Toder
V
V
D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology*; D000818:Animals; D001323:Autoantibodies; D001327:Autoimmune Diseases / Q000150:complications / Q000209:etiology* / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D004195:Disease Models, Animal; D018562:Disease Transmission, Infectious; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D007106:Immune Sera; D007116:Immunization, Passive; D018445:Infectious Disease Transmission, Vertical; D007942:Leukemia, Experimental / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D012514:Sarcoma, Kaposi / Q000276:immunology / Q000473:pathology; D013154:Spleen / Q000276:immunology / Q000473:pathology
D001323:Autoantibodies; D015395:Histocompatibility Antigens Class I; D007106:Immune Sera