Effect of prolonged exercise training without weight loss on high-density lipoprotein metabolism in overweight men.
This study examined the effect of exercise training without weight loss on high-density lipoprotein (HDL) metabolism in overweight men. We evaluated HDL metabolism using 125I-radiolabeled autologous HDL in 17 overweight men aged 40 +/- 7 years (mean +/- SD) before and after 1 year of exercise training. Subjects consumed defined diets in a metabolic kitchen during the metabolic studies. They performed endurance exercise under supervision for 1 hour four times weekly and maintained their pretraining body weight. Maximal oxygen uptake (VO2max) increased 27% (P < .001) with exercise training. HDL-cholesterol (HDL-C) and apolipoprotein (apo) A-I increased 10% and 9%, respectively (P < .001 for both), whereas triglycerides and apo B decreased 7% and 10%, respectively (P < .05). Postheparin lipoprotein lipase increased 11% (P = NS). Hepatic triglyceride lipase activity (HTGLA) decreased 12% (P < .05). The fractional catabolic rate (FCR) of HDL protein and of apo A-I decreased 5% and 7%, respectively (P < .05 for both). The synthetic rate of apo A-I increased 13% (P < .01). Increased HDL after exercise training is associated with both decreased HDL protein catabolism and increased HDL apo A-I synthesis. Weight loss is not required to increase HDL-C with exercise training in overweight men, but without weight loss, even prolonged exercise training produces only modest changes in HDL-C concentrations.
Thompson
P D
PD
Division of Cardiology, Brown University, Providence, RI, USA.
Yurgalevitch
S M
SM
Flynn
M M
MM
Zmuda
J M
JM
Spannaus-Martin
D
D
Saritelli
A
A
Bausserman
L
L
Herbert
P N
PN
D000328:Adult; D001054:Apolipoproteins A / Q000378:metabolism; D001835:Body Weight / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007700:Kinetics; D008049:Lipase / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008075:Lipoproteins, HDL / Q000378:metabolism*; D008297:Male; D015431:Weight Loss / Q000502:physiology*
D001054:Apolipoproteins A; D008055:Lipids; D008075:Lipoproteins, HDL; D008049:Lipase