[The pharmacological and laser correction of disorders of the blood microcirculatory bed in myocardial ischemia].
Microhemocirculatory changes in the ischemic myocardium concurrently exposed to low-intensive He-Ne laser, finoptin (145 micrograms/kg body weight) and perlinganit (25 micrograms/kg body weight) were experimentally studied in 50 Chinchilla rabbits. Drug and laser were daily used after 30-day inactivity for 7 days. There were anti-ischemic effects of He-Ne laser and perlinganit in increasing the number of functioning capillaries and in enhancing their functional activity. Microhemocirculatory changes induced by finoptin were less significant than those caused by perlinganit.
Ruzov
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D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D003131:Combined Modality Therapy; D004353:Drug Evaluation, Preclinical; D053685:Laser Therapy; D008297:Male; D008833:Microcirculation / Q000187:drug effects / Q000528:radiation effects; D017202:Myocardial Ischemia / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology / Q000532:radiotherapy*; D005996:Nitroglycerin / Q000494:pharmacology / Q000627:therapeutic use*; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011817:Rabbits; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*; D014700:Verapamil / Q000494:pharmacology / Q000627:therapeutic use*
D014665:Vasodilator Agents; D002245:Carbon Dioxide; D014700:Verapamil; D005996:Nitroglycerin; D010100:Oxygen