title: Tinnitus remission by lidocaine demonstrated by auditory-evoked magnetoencephalogram. A preliminary report.
abstract: An auditory-evoked magnetic field was recorded before and during tinnitus remission induced by an intravenous lidocaine injection. One and 4 kHz probe tones were presented monaurally in four tinnitus patients, and the responses were recorded using a 122-channel magnetometer. Three normal volunteers were also examined as controls. In tinnitus patients, the N100 m peak became sharper, while there was no marked change except for slight reduction in amplitude in normal subjects. Tinnitus remission by lidocaine may be related to attenuation of a masking-like effect of tinnitus on the sound-evoked responses.
authors.affiliation: Department of Hearing and Speech Science, Faculty of Medicine, Kyoto University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Shiomi
authors.forename: T
authors.initials: T
authors.lastname: Nagamine
authors.forename: N
authors.initials: N
authors.lastname: Fujiki
authors.forename: S
authors.initials: S
authors.lastname: Hirano
authors.forename: Y
authors.initials: Y
authors.lastname: Naito
authors.forename: H
authors.initials: H
authors.lastname: Shibasaki
authors.forename: I
authors.initials: I
authors.lastname: Honjo
mesh_terms: D000368:Aged; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D005072:Evoked Potentials, Auditory; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000627:therapeutic use*; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D014012:Tinnitus / Q000175:diagnosis* / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine