title: Lexical-semantic deficits in two patients with dominant thalamic infarction.
abstract: Two patients with dominant thalamic infarction, one in the tuberothalamic artery territory, the other in the paramedian artery territory, demonstrated language impairment limited to word retrieval difficulties in spontaneous language and structured naming tasks. Using a cognitive neuropsychological model of lexical processing developed in the study of patients with cortical lesions. We carried out a detailed investigation of their lexical abilities. Both patients demonstrated impairment restricted to oral and written picture naming and oral naming to definition and spared performance on tasks of lexical comprehension, oral word reading, and writing to dictation, as well as syntactic comprehension and production. Naming impairment disproportionately affected lower frequency words, and word substitutions often corresponded to objects that were semantically-related to target words. We propose that our patients' word retrieval impairments reflect a failure of thalamic input to effectively engage the cortical networks subserving lexical semantic processing, leading to degraded levels of activation as the semantic system interfaces with subsequent stages of lexical processing.
authors.affiliation: Department of Neurology, University of Florida, Gainesville, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Raymer
authors.forename: P
authors.initials: P
authors.lastname: Moberg
authors.forename: B
authors.initials: B
authors.lastname: Crosson
authors.forename: S
authors.initials: S
authors.lastname: Nadeau
authors.forename: L J
authors.initials: LJ
authors.lastname: Rothi
mesh_terms: D001037:Aphasia / Q000209:etiology / Q000523:psychology; D002544:Cerebral Infarction / Q000150:complications / Q000000981:diagnostic imaging / Q000523:psychology*; D005260:Female; D006801:Humans; D007806:Language Disorders / Q000000981:diagnostic imaging / Q000209:etiology / Q000523:psychology*; D007807:Language Tests; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D013787:Thalamic Nuclei / Q000503:physiopathology; D013788:Thalamus / Q000000981:diagnostic imaging / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed