[The possibility of nonenzymatic prothrombin activation during free-radical oxidation].
The existence of the prothrombin unenzymic activation by free oxygen radicals is experimentally proved. It has been found out that the 30-min-long action of free radicals generated by the ferrum-ascorbic system induced the thrombin activity. The HPLC-spectrum of this reaction mixture demonstrated four new fractions. A conclusion is made that there is an accidental system in the body responsible for the activation and degradation of bioactive substances.
Kaĭdashev
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IP
D001205:Ascorbic Acid / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007501:Iron / Q000378:metabolism; D008970:Molecular Weight; D010084:Oxidation-Reduction; D011516:Prothrombin / Q000032:analysis / Q000378:metabolism*; D013997:Time Factors
D005609:Free Radicals; D011516:Prothrombin; D007501:Iron; D001205:Ascorbic Acid