Assessment of beta-2-microglobulin concentration in serum and urine in rheumatoid arthritis.
Assessment of beta-2-microglobulin (beta-2-M) concentration in serum and urine was made in 50 patients with rheumatoid arthritis (RA). The most often noticed pathology was proteinuria. We observed a significant increase of beta-2-M concentration in serum of patients without rheumatoid factor and in patients with proteinuria. In all patients the concentration of beta-2-M in urine was significantly higher than in the controls. We did not observe any influence after treatment on beta-2-M concentration. The increase of the concentration of beta-2-M may be a marker for the early damage of kidney in RA.
Lewandowski
B
B
Department of Rheumatology, Medical Academy of Białystok.
Bernacka
K
K
Kucharewicz
B
B
Szmitkowski
M
M
Klimiuk
P A
PA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000150:complications / Q000652:urine*; D015415:Biomarkers / Q000032:analysis; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000209:etiology; D001613:beta 2-Microglobulin / Q000032:analysis*
D015415:Biomarkers; D001613:beta 2-Microglobulin; D003404:Creatinine