Chronic haloperidol treatment decreases preproenkephalin mRNA in the anterior pituitary: a study by solution-hybridization-RNase protection assay.
By solution-hybridization-RNase protection assay, the preproenkephalin (PPek) mRNA in the anterior pituitary (AL) of male rats was found to decrease by 42% after 3 weeks haloperidol treatment. It is concluded that dopamine may stimulate the AL enkephalinergic system at the level of gene expression.
Tang
F
F
Department of Physiology, Faculty of Medicine, University of Hong Kong, Hong Kong.
Lau
S M
SM
D000818:Animals; D018492:Dopamine Antagonists / Q000494:pharmacology*; D004591:Electrophoresis, Polyacrylamide Gel; D004745:Enkephalins / Q000032:analysis / Q000235:genetics*; D015870:Gene Expression / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D009693:Nucleic Acid Hybridization; D010902:Pituitary Gland / Q000737:chemistry / Q000187:drug effects* / Q000502:physiology; D011498:Protein Precursors / Q000032:analysis / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012260:Ribonucleases; D013997:Time Factors
D018492:Dopamine Antagonists; D004745:Enkephalins; D011498:Protein Precursors; D012333:RNA, Messenger; C033660:preproenkephalin; D012260:Ribonucleases; D006220:Haloperidol