title: Evidence for uncoupling of oxygen and glucose utilization during neuronal activation in rat striatum.
abstract: 1. Changes in regional cerebral blood flow (rCBF), tissue oxygen and extracellular glucose were measured during neuronal activation, using implanted electrodes in the striatum of freely moving rats. 2. There was a parallel increase in rCBF and oxygen in response to neuronal activation. 3. During the neuronal activation there was a decrease in extracellular glucose; following neuronal activation there was a slow rise in extracellular glucose which took 30 min to return to basal levels. 4. The implications of the different time courses of these changes are discussed.
authors.affiliation: University Laboratory of Physiology, Oxford, UK.
authors.forename: J P
authors.initials: JP
authors.lastname: Lowry
authors.forename: M
authors.initials: M
authors.lastname: Fillenz
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D002560:Cerebrovascular Circulation / Q000502:physiology; D004567:Electrodes, Implanted; D004594:Electrophysiology; D005947:Glucose / Q000378:metabolism*; D008297:Male; D017072:Neostriatum / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D010101:Oxygen Consumption / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D005947:Glucose