title: Gastrointestinal absorption of aluminum is increased in Down's syndrome.
abstract: Individuals with Down's Syndrome (DS) develop the neuropathological features of senile dementia of the Alzheimer's type (SDAT) by early middle age. Because of recent evidence that gastrointestinal (GI) aluminum (Al) absorption is increased in patients with SDAT, and that Al may contribute to associated neuropathological changes, we have investigated the GI uptake of Al in patients with DS by two methods. The first measured the absorption of 27Al at concentrations associated with antacid use, in the presence of citrate, using atomic absorption spectrometry. There was no difference between basal blood concentrations of 27Al in 15 DS subjects (36-46 years) and 15 age-matched controls. The mean increase in 27Al blood concentrations 60 minutes after the dose of Al was four times greater in the DS group than in controls (p < 0.001). The second measured GI absorption of 26Al under normal dietary conditions using accelerator mass spectrometry. With 26Al the mean Al absorption in DS subjects (n = 5) exceeded that of controls (n = 4) by a factor of 6 (p < 0.02). Although the mechanisms of enhanced absorption are unknown, the data indicate that similar abnormalities in the GI handling of Al occur in both SDAT and DS suggesting that it may be advisable to minimize dietary exposure to Al in subjects at risk of developing Alzheimer-type pathology.
authors.affiliation: Department of Psychiatry, South Tyneside District General Hospital, South Shields, United Kingdom.
authors.forename: P B
authors.initials: PB
authors.lastname: Moore
authors.forename: J A
authors.initials: JA
authors.lastname: Edwardson
authors.forename: I N
authors.initials: IN
authors.lastname: Ferrier
authors.forename: G A
authors.initials: GA
authors.lastname: Taylor
authors.forename: D
authors.initials: D
authors.lastname: Lett
authors.forename: S P
authors.initials: SP
authors.lastname: Tyrer
authors.forename: J P
authors.initials: JP
authors.lastname: Day
authors.forename: S J
authors.initials: SJ
authors.lastname: King
authors.forename: J S
authors.initials: JS
authors.lastname: Lilley
mesh_terms: D000328:Adult; D000535:Aluminum / Q000097:blood / Q000493:pharmacokinetics*; D004064:Digestive System / Q000378:metabolism*; D004314:Down Syndrome / Q000378:metabolism*; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged
chemical_list: D000535:Aluminum