title: Micronuclei-induction and its correlation to cell survival in HeLa cells treated with different doses of adriamycin.
abstract: The treatment of HeLa cells with different concentrations of adriamycin (0, 5, 10, 25, 50 and 100 microg/ml) resulted in a significant and dose-dependent decline in the cell survival. Conversely, the frequency of micronuclei increased in a concentration-dependent manner. The micronuclei-induction and cell survival were found to be inversely related.
authors.affiliation: Department of Radiobiology, Kasturba Medical College, Manipal, India.
authors.forename: G C
authors.initials: GC
authors.lastname: Jagetia
authors.forename: V
authors.initials: V
authors.lastname: Nayak
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage / Q000494:pharmacology*; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D015162:Micronucleus Tests
chemical_list: D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin