title: [Syndromes with neural tube defects: epidemiologic analysis in Spain].
abstract: OBJECTIVE
  We present, from an epidemiological perspective, the analysis of syndromes which present neural tube defects (NTD). Although there are many epidemiological studies on NTD all over the world, most of them are on isolated NTD; that is, when the infant only has NTD as the only anomaly.
  
  
  METHODS
  The methodology is based on the review of hospital records of infants with congenital anomalies. This permitted the analysis of the prevalence.
  
  
  RESULTS
  The results show that the frequency of syndromes with NTD is 27.5 time higher among stillborn infants than among liveborn infants. Nevertheless, there are not many syndromes in which the NTD are present more or less frequently. In fact, only 1.93% of the total cases with syndromes presented NTD, with the majority (43.4%) with genetic etiology. We also analyze the specific types of syndromes with NTD.
authors.affiliation: ECEMC, Facultad de Medicina, Universidad Complutense, Madrid.
authors.forename: M L
authors.initials: ML
authors.lastname: Martínez-Frías
authors.forename: V
authors.initials: V
authors.lastname: Félix Rodríguez
authors.forename: F
authors.initials: F
authors.lastname: Hernández Ramón
authors.forename: M
authors.initials: M
authors.lastname: Martín Bermejo
authors.forename: J A
authors.initials: JA
authors.lastname: López Soler
authors.forename: A
authors.initials: A
authors.lastname: Ayala Garcés
authors.forename: E
authors.initials: E
authors.lastname: Bermejo Sánchez
authors.forename: E
authors.initials: E
authors.lastname: Rodríguez Pinilla
mesh_terms: D005313:Fetal Death / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D009436:Neural Tube Defects / Q000453:epidemiology*; D013030:Spain / Q000453:epidemiology; D013577:Syndrome