Utilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239.
We examined chemokine receptors for the ability to facilitate the infection of CD4-expressing cells by viruses containing the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239. Expression of either human or simian C-C chemokine receptor CCR5 allowed the SIVmac239 envelope glycoproteins to mediate virus entry and cell-to-cell fusion. Thus, distantly related immunodeficiency viruses such as SIV and the primary human immunodeficiency virus type 1 isolates can utilize CCR5 as an entry cofactor.
Marcon
L
L
Division of Human Retrovirology, Dana-Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Choe
H
H
Martin
K A
KA
Farzan
M
M
Ponath
P D
PD
Wu
L
L
Newman
W
W
Gerard
N
N
Gerard
C
C
Sodroski
J
J
D000818:Animals; D001483:Base Sequence; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D004279:DNA, Viral; D015686:Gene Products, env / Q000235:genetics / Q000276:immunology*; D006367:HeLa Cells; D006801:Humans; D008969:Molecular Sequence Data; D019713:Receptors, CCR5; D018121:Receptors, Cytokine / Q000276:immunology*; D015728:Receptors, HIV / Q000276:immunology*; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification / Q000502:physiology*
D004279:DNA, Viral; D015686:Gene Products, env; D019713:Receptors, CCR5; D018121:Receptors, Cytokine; D015728:Receptors, HIV