title: Schistosoma mansoni: permanence of modulation of the granulomatous inflammatory response in mice cured in the chronic phase.
abstract: Persistence of down regulation of granuloma size was studied in mice chronically infected with Schistosoma mansoni and cured by chemotherapy. The animals were reinfected at 20-, 50-, 110-, and 140-day intervals after treatment, and sacrificed 60 days post-infection. Reinfected animals were able to modulate the granulomatous inflammatory response, thus preventing a new acute phase. These findings may contribute to the explanation for the decrease of morbidity from human schistosomiasis seen in endemic areas following mass treatment.
authors.affiliation: Departamiento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Mina Gerais.
authors.forename: P M
authors.initials: PM
authors.lastname: Coelho
authors.forename: N H
authors.initials: NH
authors.lastname: Toppa
authors.forename: J S
authors.initials: JS
authors.lastname: Feldmann
authors.forename: R
authors.initials: R
authors.lastname: Gonçalves
authors.forename: R T
authors.initials: RT
authors.lastname: Mello
mesh_terms: D000818:Animals; D006099:Granuloma / Q000209:etiology / Q000469:parasitology*; D007249:Inflammation; D008109:Liver Diseases, Parasitic / Q000188:drug therapy / Q000473:pathology*; D051379:Mice; D010073:Oxamniquine / Q000627:therapeutic use*; D012555:Schistosomiasis mansoni / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D012556:Schistosomicides / Q000627:therapeutic use
chemical_list: D012556:Schistosomicides; D010073:Oxamniquine