Estrogen replacement therapy and exercise performance in postmenopausal women with coronary artery disease.
We treated 10 postmenopausal women with stable angina, positive exercise test, and documented coronary artery disease with oral conjugated equine estrogen (0.625 mg/day of Premarin) or placebo for 4 weeks, in random order, with crossover after a 4-week washout period. Exercise tests, performed after each treatment period while the patients were taking their usual antianginal drugs showed no differences; thus, short-term estrogen does not improve exercise-induced ischemia compared with placebo.
Sbarouni
E
E
2nd Department of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece.
Kyriakides
Z S
ZS
Nikolaou
N
N
Kremastinos
D T
DT
D000368:Aged; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology*; D018592:Cross-Over Studies; D045166:Estradiol Congeners / Q000494:pharmacology; D015914:Estrogen Replacement Therapy; D015444:Exercise / Q000502:physiology*; D005260:Female; D006321:Heart / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause
D045166:Estradiol Congeners