Bone resorption inhibitors from hop extract.
We searched hop extract for active component(s) that inhibited bone resorption in the pit formation assay, and isolated xanthohumol and humulone as active ingredients. Especially humulone had extraordinarily strong inhibitory activity and the IC50 (concentration of 50% inhibition) value was 5.9 x 10(-9)M.
Tobe
H
H
Pharma Research and Development Division, Hoechst Japan Limited, Saitama, Japan.
Muraki
Y
Y
Kitamura
K
K
Komiyama
O
O
Sato
Y
Y
Sugioka
T
T
Maruyama
H B
HB
Matsuda
E
E
Nagai
M
M
D001862:Bone Resorption / Q000188:drug therapy*; D053138:Cyclohexenes; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010945:Plants, Edible / Q000737:chemistry*; D011427:Propiophenones / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology
D053138:Cyclohexenes; D005419:Flavonoids; D010936:Plant Extracts; D011427:Propiophenones; D013729:Terpenes; C007966:humulon; C104536:xanthohumol