Soluble tumour necrosis factor receptor release after anti-CD3 monoclonal antibody treatment in mice is independent of tumour necrosis factor-alpha release.
The involvement of TNF-alpha in the release of soluble TNF receptors was assessed in mice, treated with anti-CD3 monoclonal antibodies. After treatment with three different anti-CD3 mAb, we simultaneously studied serum levels of TNF-alpha, soluble TNF receptor P55 and P75. All three anti-CD3 mAb triggered the release of both of the soluble TNF receptors, whereas only one of the anti-CD3 mAb triggered TNF-alpha release. These data demonstrate that in our model soluble TNF receptor release is independent of TNF-alpha release.
Vossen
A C
AC
Department of Immunology, Erasmus University, Rotterdam, The Netherlands.
Tibbe
G J
GJ
Buurman
W A
WA
Benner
R
R
Savelkoul
H F
HF
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D017252:CD3 Complex / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D017455:Receptors, IgE / Q000378:metabolism; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D017252:CD3 Complex; D017455:Receptors, IgE; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha