[The effect of amtizol on energy metabolism and lipid peroxidation processes in acute hypoxia].
The effect of amthizol on energy metabolism and lipid peroxidation in the brain, heart, liver, kidneys, and skeletal muscles was studied in experiments on rats with acute hypoxia (altitude 8,000 m, exposure 30 min). Intraperitoneal injection of amthizol (25 mg/kg) 30 min before the development of hypoxia prevented disorders of energy metabolism in the organs and inhibited activation of lipid peroxidation.
Smirnov
A V
AV
Zarubina
I V
IV
Krivoruchko
B I
BI
D000208:Acute Disease; D000818:Animals; D001273:Atmosphere Exposure Chambers; D004353:Drug Evaluation, Preclinical; D004734:Energy Metabolism / Q000187:drug effects*; D000860:Hypoxia / Q000188:drug therapy* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D013830:Thiadiazoles / Q000494:pharmacology* / Q000627:therapeutic use
D013830:Thiadiazoles; C044365:amtizol