A glucose-rich diet shortens longevity of mice.
High plasma levels of glucose and insulin over long-time periods play an important role in the genesis of diabetic complications. There is evidence that the long term consumption of glucose-rich diet by rats is detrimental to insulin sensitivity. We investigated the effect of a glucose-rich diet on longevity of 70 female mice which were compared to 70 mice on a control diet. The average age of death of the control group was 568 +/- 139 days compared to 511 +/- 170 for the glucose group and the seven oldest mice of the control group died at age 890 +/- 52 days, while the seven oldest mice of the glucose group died at 833 +/- 49 days. These differences are statistically significant (P < or = 0.05). Our work shows that a life-long intake of a diet with 20% of total energy derived from glucose leads to a significant reduction of the average and maximal life-span in female mice and thus, supports previous observations of detrimental effects of high glucose intake over long periods.
Mlekusch
W
W
Institute of Medical Chemistry and Pregl Laboratory, Karl-Franzens-Universität-Graz, Austria.
Lamprecht
M
M
Ottl
K
K
Tillian
M
M
Reibnegger
G
G
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D004032:Diet; D005260:Female; D005947:Glucose / Q000494:pharmacology*; D008136:Longevity / Q000187:drug effects*; D051379:Mice
D005947:Glucose