Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro.
An in-situ ELISA was used as a primary screen to test the effects of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro. Over 40 of the compounds displayed some form of anticryptosporidial activity, and dose-response curves were generated for 40 of these. The in-situ ELISA makes a highly effective primary, pharmaceutical screen for C parvum, to be used prior to more detailed microscopical, toxicological or in-vivo assays.
Woods
K M
KM
Division of Biology, Kansas State University, Manhattan 66506, USA.
Nesterenko
M V
MV
Upton
S J
SJ
D000818:Animals; D003049:Coccidiostats / Q000494:pharmacology; D016785:Cryptosporidium parvum / Q000187:drug effects* / Q000254:growth & development; D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay
D003049:Coccidiostats