Stability of vinblastine sulphate in 0.9% sodium chloride in polypropylene syringes.
The stability of vinblastine sulphate diluted in 0.9% sodium chloride solution for injection was studied. Vinblastine sulphate was reconstituted with 0.9% sodium chloride solution for injection to concentration of 1.0 mg/mL and stored in polypropylene syringes at 25 degrees C +/- 1 degree C protected from light. On different days the solutions were analysed and the vinblastine concentration was determined by high-performance liquid chromatography. An high-pressure liquid chromatographic method is described for the quantitative determination of vinblastine in the presence of its degradation products. The degradation of vinblastine was studied by examining the percentage changes from the theoretical concentrations for each solution. The results of these studies indicate that vinblastine solutions in 0.9% sodium chloride solution for injection (1 mg/mL) in polypropylene syringes at 25 degrees C +/- 1 degree C protected from light are stable for up to one month.
Girona
V
V
Physical Chemistry Unit, Faculty of Pharmacy, University of Barcelona.
Prat
J
J
Pujol
M
M
Muñoz
M
M
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000032:analysis*; D004355:Drug Stability; D011126:Polypropylenes; D013594:Syringes; D014747:Vinblastine / Q000008:administration & dosage / Q000032:analysis*
D000972:Antineoplastic Agents, Phytogenic; D011126:Polypropylenes; D014747:Vinblastine