Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA.
We investigated the effects of low-dose eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the incidence and growth of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in rats fed a high-fat (HF) diet. We also examined the effects of these treatments on the fatty acid composition of tumour and serum. Tumour incidence was significantly decreased by the administration of low-dose EPA and DHA, whereas their inhibitory effects on tumour growth did not reach significance. Serum arachidonic acid (AA) level was decreased by the administration of low-dose EPA and tended to be decreased by the administration of low-dose DHA, whereas tumour AA levels were not changed. The administration of low-dose EPA and DHA may be useful for inhibiting the incidence of breast cancer.
Noguchi
M
M
Operation Center, Kanazawa University Hospital, Takara-machi, Japan.
Minami
M
M
Yagasaki
R
R
Kinoshita
K
K
Earashi
M
M
Kitagawa
H
H
Taniya
T
T
Miyazaki
I
I
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D001835:Body Weight; D002273:Carcinogens; D002455:Cell Division; D018752:Diet, Fat-Restricted; D004041:Dietary Fats; D004281:Docosahexaenoic Acids / Q000627:therapeutic use*; D015118:Eicosapentaenoic Acid / Q000627:therapeutic use*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D004041:Dietary Fats; D005230:Fatty Acids, Nonesterified; D004281:Docosahexaenoic Acids; D015127:9,10-Dimethyl-1,2-benzanthracene; D015118:Eicosapentaenoic Acid