title: Role REVersal: understanding how RRE RNA binds its peptide ligand.
abstract: The structure of a complex between the HIV Revresponsive element (RRE) RNA and a fragment of the Rev protein has recently been determined by NMR. Together with previous studies of the Tat-TAR complex, these results show how RNA elements with considerable tertiary structure are able to play a more active role in directing binding to elements of protein secondary structure.
authors.affiliation: Department of Biology, University of California at Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA. grate@biology.ucsc.edu
authors.forename: D
authors.initials: D
authors.lastname: Grate
authors.forename: C
authors.initials: C
authors.lastname: Wilson
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry; D002628:Chemoreceptor Cells; D029968:Escherichia coli Proteins; D015694:Gene Products, rev / Q000737:chemistry / Q000378:metabolism*; D015696:Gene Products, tat / Q000737:chemistry; D015752:Genes, env / Q000235:genetics*; D006678:HIV / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008565:Membrane Proteins / Q000737:chemistry; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism; D017433:Protein Structure, Secondary; D016601:RNA-Binding Proteins / Q000378:metabolism; D011956:Receptors, Cell Surface; D054321:rev Gene Products, Human Immunodeficiency Virus; D054322:tat Gene Products, Human Immunodeficiency Virus
chemical_list: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D015694:Gene Products, rev; D015696:Gene Products, tat; D008565:Membrane Proteins; D010446:Peptide Fragments; D016601:RNA-Binding Proteins; D011956:Receptors, Cell Surface; C057331:Tar protein, E coli; D054321:rev Gene Products, Human Immunodeficiency Virus; D054322:tat Gene Products, Human Immunodeficiency Virus