Acute reversibility of pulmonary hypertension predicts neither long-term hemodynamic response nor outcome in patients awaiting heart transplantation.
For transplant wait-list patients with end-stage congestive heart failure, reversibility of pulmonary hypertension tested with acute administration of vasodilators is a prerequisite to listing for transplantation. We have shown that the magnitude of the initial pulmonary vasodilatory response to nitroprusside predicts neither the extent of the long-term hemodynamic response nor the subsequent need for transplantation versus clinical improvement and removal from transplant consideration.
Levine
T B
TB
Division of Cardiology, Henry Ford Hospital, Detroit, Michigan 48202, USA.
Levine
A B
AB
Goldberg
A D
AD
Tobes
M C
MC
Narins
B
B
Goldstein
S
S
Lesch
M
M
D000959:Antihypertensive Agents / Q000494:pharmacology*; D006333:Heart Failure / Q000503:physiopathology* / Q000601:surgery*; D016027:Heart Transplantation / Q000502:physiology*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000188:drug therapy*; D009599:Nitroprusside / Q000494:pharmacology*; D011651:Pulmonary Artery / Q000187:drug effects / Q000502:physiology; D012189:Retrospective Studies; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
D000959:Antihypertensive Agents; D014665:Vasodilator Agents; D009599:Nitroprusside