title: Study of gastric emptying in patients with pancreatic diabetes (chronic pancreatitis) using acetaminophen and isotope.
abstract: The gastric emptying function tests were carried out in eight patients with pancreatic diabetes, who were classified into two groups according to the coefficient of variation in the R-R interval in ECG (C.V. R-R) on the normal subjects: < or = the mean - 2SD (the autonomic nerve dysfunction group: AND+ group) and > the mean - 2SD (the autonomic nerve normal group: AND- group). Both the gastric emptying of liquid food by the acetaminophen method and that of solid food by the isotope method were significantly reduced in the AND+ group than in the AND- and normal groups. In addition, a significant correlation was found between the C.V. R-R and the serum acetaminophen concentration (a 45 min value) and the % gastric retention of isotope (a 120 min value). The above results demonstrated that even pancreatic diabetes might be complicated by gastroparesis diabeticorum among autonomic nerve dysfunction. There was a close relation of delayed gastric emptying to the C.V. R-R in ECG or an index of the vagus nerve function.
authors.affiliation: 3rd Department of Internal Medicine, Hirosaki University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Takebe
authors.forename: M
authors.initials: M
authors.lastname: Ishii
authors.forename: F
authors.initials: F
authors.lastname: Kasai
authors.forename: Y
authors.initials: Y
authors.lastname: Arai
authors.forename: Y
authors.initials: Y
authors.lastname: Tando
authors.forename: N
authors.initials: N
authors.lastname: Yamada
authors.forename: A
authors.initials: A
authors.lastname: Terada
authors.forename: T
authors.initials: T
authors.lastname: Suda
mesh_terms: D000082:Acetaminophen; D000328:Adult; D001342:Autonomic Nervous System Diseases / Q000150:complications* / Q000503:physiopathology; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000503:physiopathology; D005746:Gastric Emptying; D006801:Humans; D008875:Middle Aged; D010195:Pancreatitis / Q000503:physiopathology*; D013270:Stomach / Q000294:innervation; D013667:Technetium
chemical_list: D000082:Acetaminophen; D013667:Technetium