Automated modelling of the transmembrane region of G-protein coupled receptor by Swiss-model.
Molecular modelling of the transmembrane helices of G-protein coupled receptors is an increasingly used method to identify the possible three-dimensional environment of key residues. Thereby site-directed mutagenesis experiments, aimed at the understanding of the receptor-ligand interactions, can be designed in a rational way. The modelling methods are however not generally available to experimentalists, and often require expensive software and hardware. To overcome these limitations, we have constructed a World Wide Web server for the automated protein modelling of user-defined transmembrane helices. The service is freely available at this address: http:/(/)expasy.hcuge.ch/swissmod/SWISS-MODEL.++ +html.
Peitsch
M C
MC
BioInformatics, Glaxo Institute for Molecular Biology, Geneva, Switzerland.
Herzyk
P
P
Wells
T N
TN
Hubbard
R E
RE
D000818:Animals; D003195:Computer Communication Networks; D003198:Computer Simulation; D016208:Databases, Factual; D019204:GTP-Binding Proteins / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D017433:Protein Structure, Secondary; D011956:Receptors, Cell Surface / Q000737:chemistry*
D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins