title: Comparative serum estradiol profiles from a new once-a-week transdermal estradiol patch and a twice-a-week transdermal estradiol patch.
abstract: Two identical open-label, randomized crossover studies were conducted to compare serum estradiol profiles from the new 12.5- and 25-cm2 once-a-week adhesive patches with those from the 10- and 20-cm2 commercially available twice-a-week Estraderm patches when applied as directed during a 1-week patch-wear period. Both studies were conducted in healthy postmenopausal women; serum estradiol levels were determined by gas chromatography/mass spectroscopy (GC/MS). Although both sizes of both patch treatments produced mean serum estradiol levels in the therapeutic range, the once-a-week patch provided more constant mean levels, avoiding large peak-to-trough fluctuations. As expected, the differences in mean serum estradiol concentrations between the two patch treatments occurred during the second application of the twice-a-week patch. Based on these results, the once-a-week drug in adhesive patch appears to be an acceptable means of hormone replacement therapy.
authors.affiliation: Department of Pharmacokinetics and Drug Metabolism, 3M Pharmaceuticals, St. Paul, Minnesota 55144, USA.
authors.forename: L I
authors.initials: LI
authors.lastname: Harrison
authors.forename: D J
authors.initials: DJ
authors.lastname: Riedel
authors.forename: S F
authors.initials: SF
authors.lastname: Chang
authors.forename: J P
authors.initials: JP
authors.lastname: Jacobson
authors.forename: J A
authors.initials: JA
authors.lastname: Sellers
authors.forename: C M
authors.initials: CM
authors.lastname: Kanniainen
authors.forename: J K
authors.initials: JK
authors.lastname: Crowley
authors.forename: P H
authors.initials: PH
authors.lastname: Hinderling
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D003692:Delayed-Action Preparations; D004958:Estradiol / Q000008:administration & dosage / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged
chemical_list: D003692:Delayed-Action Preparations; D004958:Estradiol