title: Acute reversibility of pulmonary hypertension predicts neither long-term hemodynamic response nor outcome in patients awaiting heart transplantation.
abstract: For transplant wait-list patients with end-stage congestive heart failure, reversibility of pulmonary hypertension tested with acute administration of vasodilators is a prerequisite to listing for transplantation. We have shown that the magnitude of the initial pulmonary vasodilatory response to nitroprusside predicts neither the extent of the long-term hemodynamic response nor the subsequent need for transplantation versus clinical improvement and removal from transplant consideration.
authors.affiliation: Division of Cardiology, Henry Ford Hospital, Detroit, Michigan 48202, USA.
authors.forename: T B
authors.initials: TB
authors.lastname: Levine
authors.forename: A B
authors.initials: AB
authors.lastname: Levine
authors.forename: A D
authors.initials: AD
authors.lastname: Goldberg
authors.forename: M C
authors.initials: MC
authors.lastname: Tobes
authors.forename: B
authors.initials: B
authors.lastname: Narins
authors.forename: S
authors.initials: S
authors.lastname: Goldstein
authors.forename: M
authors.initials: M
authors.lastname: Lesch
mesh_terms: D000959:Antihypertensive Agents / Q000494:pharmacology*; D006333:Heart Failure / Q000503:physiopathology* / Q000601:surgery*; D016027:Heart Transplantation / Q000502:physiology*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000188:drug therapy*; D009599:Nitroprusside / Q000494:pharmacology*; D011651:Pulmonary Artery / Q000187:drug effects / Q000502:physiology; D012189:Retrospective Studies; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D000959:Antihypertensive Agents; D014665:Vasodilator Agents; D009599:Nitroprusside