Effects of a pH 7.4, lactate-based and a pH 7.4, bicarbonate-based peritoneal dialysis solutions on neutrophil superoxide generation.
Neutrophil superoxide formation was similar when cells were incubated in self-made, non-autoclaved pH 7.4, lactate-based peritoneal dialysis solutions or in their self-made, non-autoclaved, pH 7.4, bicarbonate-based counterparts. On the other hand, commercially available, autoclaved, pH 7.4, lactate-based peritoneal dialysis solutions resulted in inhibition of superoxide production when compared to their self-made, non-autoclaved, pH 7.4, lactate-based or bicarbonate-based counterparts. The cause for this inhibition of superoxide generation is at present unknown.
Ing
T S
TS
Department of Medicine, Loyola University Chicago, Stritch School of Medicine, Maywood, USA.
Patel
B P
BP
Patel
J A
JA
Patel
N K
NK
Yu
A W
AW
Osman
A
A
Zhou
F Q
FQ
D000328:Adult; D001639:Bicarbonates / Q000494:pharmacology*; D015314:Dialysis Solutions / Q000592:standards*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000494:pharmacology*; D008297:Male; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010530:Peritoneal Dialysis; D013242:Sterilization; D013481:Superoxides / Q000378:metabolism*
D001639:Bicarbonates; D015314:Dialysis Solutions; D007773:Lactates; D013481:Superoxides