title: Intracellular pH and H+ buffering capacity in guinea-pigs with left ventricular hypertrophy induced by constriction of the thoracic aorta.
abstract: Intracellular pH (pHi) was measured in left ventricular myocytes from hearts hypertrophied by constriction of the thoracic aorta. There was a continuous relation between an increase in heart-to-body weight ratio and a decrease in pHi (mean +/- S.D., 7.06 +/- 0.18 pH units in control hearts vs. 6.87 +/- 0.17 pH units in hypertrophied hearts). Intracellular H+ buffering capacity (beta) increased as pHi fell, but the value of beta was independent of hypertrophy per se.
authors.affiliation: Institute of Urology & Nephrology, London, UK.
authors.forename: W R
authors.initials: WR
authors.lastname: Wallis
authors.forename: C
authors.initials: C
authors.lastname: Wu
authors.forename: D J
authors.initials: DJ
authors.lastname: Sheridan
authors.forename: C H
authors.initials: CH
authors.lastname: Fry
mesh_terms: D000643:Ammonium Chloride / Q000378:metabolism; D000818:Animals; D001013:Aorta, Thoracic / Q000502:physiology*; D001835:Body Weight / Q000502:physiology; D002021:Buffers; D017629:Gap Junctions / Q000502:physiology; D006168:Guinea Pigs; D006863:Hydrogen-Ion Concentration; D017379:Hypertrophy, Left Ventricular / Q000378:metabolism* / Q000473:pathology; D009124:Muscle Proteins / Q000096:biosynthesis; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009929:Organ Size / Q000502:physiology
chemical_list: D002021:Buffers; D009124:Muscle Proteins; D000643:Ammonium Chloride