title: Hepatoid gastric carcinoma. A case report.
abstract: Alpha-fetoprotein (AFP) is normally produced by primary hepatic neoplasms and germ cell tumors. There have, however, been reports of its production in cases of gastrointestinal tract adenocarcinoma. Gastric hepatoid carcinomas constitute a clinicopathological entity of recent acquisition and have certain common characteristics, which include the presence of hepatoid foci and frequent liver metastases, even in cases of early gastric cancer, and increasing serum AFP levels. In this study the case of one patient who underwent gastric resection and presented clinical, humoral, histological and immunohistochemical characteristics typical of hepatoid gastric carcinoma is reported. More biological studies, as well as precise criteria for pathological definition and therapy, are still necessary for a better understanding of this pathology.
authors.affiliation: Department of General Surgery III, University of Siena, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Lorenzi
authors.forename: C
authors.initials: C
authors.lastname: Vindigni
authors.forename: S A
authors.initials: SA
authors.lastname: Tripodi
authors.forename: T
authors.initials: T
authors.lastname: Megha
authors.forename: S
authors.initials: S
authors.lastname: Mancini
authors.forename: G
authors.initials: G
authors.lastname: Francini
mesh_terms: D000230:Adenocarcinoma / Q000097:blood* / Q000188:drug therapy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood; D004317:Doxorubicin / Q000627:therapeutic use; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000097:blood* / Q000188:drug therapy; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D000509:alpha-Fetoproteins; D016685:Mitomycin; D004317:Doxorubicin; D005472:Fluorouracil