Synthetic analogues of netropsin and distamycin. III. Synthesis of a pyridine analogue of the pyrrolecarboxamide antitumour antibiotics.
The synthesis of a new pyridine analogue of netropsin, N,N'-bis[6-(N-3-dimethylaminopropyl) carbamoylpyridin-2-yl] pyridine-2,5-dicarboxamide (VII) is described. The potential for use of VII as a carrier to place chemical functionalities into the minor groove of DNA which are capable of modifying DNA is discussed.
Bielawski
K
K
Department of Organic Chemistry, Medical Academy of Białystok.
Bartulewicz
D
D
Krajewska
D
D
Rózański
A
A
D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis*; D001483:Base Sequence; D001665:Binding Sites; D017076:Computer-Aided Design; D004247:DNA / Q000737:chemistry; D004214:Distamycins / Q000737:chemistry*; D015195:Drug Design; D008958:Models, Molecular; D009429:Netropsin / Q000031:analogs & derivatives*; D009539:Nicotinic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D010848:Picolinic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D017422:Sequence Analysis, DNA
D000903:Antibiotics, Antineoplastic; D004214:Distamycins; C104267:N,N'-bis(6-(N-3-dimethylaminopropyl)carbamoylpyridin-2-yl)pyridine-2,5-dicarboxamide; D009539:Nicotinic Acids; D010848:Picolinic Acids; D009429:Netropsin; C030000:stallimycin; D004247:DNA