title: [Seroprevalence of hepatitis A in hemophiliacs].
abstract: OBJECTIVE
  To study the seroprevalence of hepatitis A virus (HAV) infection in haemophiliacs treated with factor VIII/IX concentrates.
  
  
  METHODS
  Anti-HAV IgG antibodies were tested in 133 haemophiliacs previously treated (20 of them only infused with virus-inactivated factor concentrates), 11 previously untreated haemophiliacs and 60 healthy individuals (> 25 yr. old).
  
  
  RESULTS
  The overall anti-HAV prevalence was 43%. Anti-HAV was found in 2 (10%) of the patients treated only with virus-inactivated concentrates and in 55 (49%) of those who had received non-inactivated concentrates. The seroprevalence in the untreated haemophiliacs was 27% and 90% in the healthy control group. The anti-HAV seroprevalence showed a significant (p < 0.001) dependence on patient age, it being higher in patients aged > 25 (77%) than in those aged 10-25 (31%) and < 10 (4%). The seroprevalence of anti-HAV was lower in the treated haemophiliacs aged 25 or more than in the healthy individuals, although the difference did not reach statistical significance (p = 0.06).
  
  
  CONCLUSIONS
  These results show that the seroprevalence of HAV infection in haemophiliacs is similar to that in the general population, and that there is not a significant excess of HAV infections amongst haemophiliacs with high exposure to coagulation factor concentrates.
authors.affiliation: Unidad de Coagulopatías Congénitas, Hospital La Fe, Valencia.
authors.forename: R
authors.initials: R
authors.lastname: Molina
authors.forename: J I
authors.initials: JI
authors.lastname: Lorenzo
authors.forename: M D
authors.initials: MD
authors.lastname: Gómez
authors.forename: A
authors.initials: A
authors.lastname: Sarrión
authors.forename: S
authors.initials: S
authors.lastname: Haya
authors.forename: F
authors.initials: F
authors.lastname: Querol
authors.forename: J A
authors.initials: JA
authors.lastname: Aznar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D006467:Hemophilia A / Q000453:epidemiology*; D006506:Hepatitis A / Q000453:epidemiology* / Q000209:etiology; D035922:Hepatitis A Antibodies; D006508:Hepatitis Antibodies / Q000097:blood; D006801:Humans; D015995:Prevalence; D065227:Transfusion Reaction
chemical_list: D035922:Hepatitis A Antibodies; D006508:Hepatitis Antibodies