Serum levels of unbound free fatty acids. II: The effect of intralipid administration in premature infants.
BACKGROUND
Fatty acids (FFA) are key nutrients in maintaining physiologic homeostasis and in the form of Intralipid administration, they are important sources of nutrition in the premature newborn infant. Complexed with albumin, fatty acids have a small but important fraction that remains unbound in the aqueous phase.


OBJECTIVE
The goal of this study was to examine the levels of serum levels of unbound free fatty acids (FFAu) in premature newborns following Intralipid administration.


METHODS
A fluorescent probe acrylodated intestinal fatty acid binding protein (ADIFAB) was used to measure (FFAu) before Intralipid and during increasing rates of infusion.


RESULTS
There were significant differences between (FFAu) values obtained before Intralipid and levels after the infusion of 1.0, 2.0, and 3.0 g/kg/day (p < 0.05). Regression analysis of Intralipid dose and FFAu yielded an r = 0.438 and the following relationship: [FFAu] = 26.39 + 3.60 * IL (g/kg/day).


CONCLUSIONS
Intralipid administration results in significant elevation of FFAu in the very low birth weight infant.
Ruben
S
S
Department of Pediatrics, UMDNJ-Robert Wood Johnson Medical School, St. Peter's Medical Center, New Brunswick 08903, USA.
Kleinfeld
A M
AM
Richeiri
G V
GV
Hiatt
M
M
Hegyi
T
T
D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D008297:Male; D009994:Osmolar Concentration; D010288:Parenteral Nutrition
D005217:Fat Emulsions, Intravenous; D005230:Fatty Acids, Nonesterified