Prospective randomized study of sulindac versus calcium and calciferol for upper gastrointestinal polyps in familial adenomatous polyposis.
Eighteen patients with familial adenomatous polyposis (FAP) who had previously undergone colectomy but had upper gastrointestinal polyps were studied in a double-blind randomized crossover trial comparing sulindac with calcium and calciferol. Sulindac produced a reduction in the crypt proliferation index in the gastric epithelium of patients but did not significantly affect duodenal mucosa. Calcium with calciferol did not have any effects on crypt proliferation index in patients with FAP.
Seow-Choen
F
F
Department of Colorectal Surgery, Singapore General Hospital, Singapore.
Vijayan
V
V
Keng
V
V
D011125:Adenomatous Polyposis Coli / Q000188:drug therapy* / Q000473:pathology; D002118:Calcium / Q000627:therapeutic use*; D002455:Cell Division; D003138:Common Bile Duct Neoplasms / Q000188:drug therapy* / Q000473:pathology; D018592:Cross-Over Studies; D004379:Duodenal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004872:Ergocalciferols / Q000627:therapeutic use*; D006801:Humans; D007417:Intestinal Polyps / Q000188:drug therapy* / Q000473:pathology; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013467:Sulindac / Q000627:therapeutic use*
D004872:Ergocalciferols; D013467:Sulindac; D002118:Calcium