Enhancement of metastasis of prostate adenocarcinoma cells by immune-suppressive cyclosporine A.
The rate and extent of metastasis by prostate adenocarcinoma-III cells was enhanced in Lobund-Wistar rats by administration of immune-suppressive cyclosporine A. PA-III cells spread from the subcutaneous PA-III-derived tumor, through ipsilateral lymph nodes, to the lungs in which they developed secondary tumors. Swollen lymph nodes, compacted with PA-III cells, indicate that the 'normal' host-engendered level of intravascular non-specific restraints to metastasis were abrogated by CSA.
Pollard
M
M
Lobund Laboratory, University of Notre Dame, IN 4G556, USA.
D000230:Adenocarcinoma / Q000556:secondary*; D000818:Animals; D016572:Cyclosporine / Q000009:adverse effects*; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008175:Lung Neoplasms / Q000556:secondary*; D008207:Lymphatic Metastasis; D008297:Male; D011471:Prostatic Neoplasms; D051381:Rats; D017208:Rats, Wistar; D013047:Specific Pathogen-Free Organisms
D007166:Immunosuppressive Agents; D016572:Cyclosporine