[The effect of thymogen on the chromosome aberration level in a culture of human peripheral blood lymphocytes].
The influence of thymogene on the frequency of spontaneous and formaldehyde-induced chromosome aberrations in human peripheral blood lymphocytes was detected. High thymogene concentration (1000, 100, and 10 micrograms/ml) significantly decreased the proliferative activity of lymphocytes in culture. Low thymogene concentrations (1.0; 0.1; 0.01; and 0.001 microgram/ml) didn't decrease the mitotic activity of culture and hadn't mutagenic activity. Thymogene concentrations 1.0; 0.1; and 0.001 microgram/ml significantly decreased the frequency of formaldehyde-induced chromosome aberrations in lymphocytes. Possible mechanisms of gene protection by thymogene is discussed.
Rushkovskiĭ
S R
SR
Chegrinets
S E
SE
Bezrukov
V F
VF
Khrapunov
S N
SN
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004151:Dipeptides; D004305:Dose-Response Relationship, Drug; D005557:Formaldehyde / Q000494:pharmacology; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000648:ultrastructure; D008677:Metaphase / Q000187:drug effects; D009153:Mutagens / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D004151:Dipeptides; D009153:Mutagens; D010455:Peptides; C060736:thymogen; D005557:Formaldehyde