[The participation of the serotoninergic system in regulating the activity of the central glutamatergic/aspartatergic and GABA-ergic synapses].
Selective lesion of the serotoninergic system diminished the synaptic uptake of 3H-L-glutamic acid and 3H-DL-aspartic acid, as well as the Na+(-dependent) binding of 3H-L-glutamic acid in the cortex and the brain stem. The data obtained suggest an ability of the serotoninergic system to modify presynaptic processes in amino-acidergic neurons of the CNS.
Grigor'ev
I P
IP
Neokesariĭskiĭ
A A
AA
Otellin
V A
VA
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000818:Animals; D001224:Aspartic Acid / Q000187:drug effects / Q000378:metabolism*; D001933:Brain Stem / Q000187:drug effects / Q000378:metabolism*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D018698:Glutamic Acid / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009498:Neurotoxins / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017459:Receptors, Amino Acid / Q000187:drug effects / Q000378:metabolism*; D018079:Receptors, GABA / Q000187:drug effects / Q000378:metabolism*; D017470:Receptors, Glutamate / Q000187:drug effects / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D013569:Synapses / Q000187:drug effects / Q000378:metabolism*; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000187:drug effects / Q000378:metabolism
D009498:Neurotoxins; D017459:Receptors, Amino Acid; D018079:Receptors, GABA; D017470:Receptors, Glutamate; D011985:Receptors, Serotonin; C031959:aspartic acid receptor; D001224:Aspartic Acid; D015116:5,7-Dihydroxytryptamine; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid