[New possibilities for metabolic protection from hypoxia in pregnant rats and their progeny].
Individual resistance of pregnant rats and the newborns to acute hypoxic hypoxia was studied. It was found that individual resistance of the organism to hypoxia significantly decreases in the last period of pregnancy. A new drug limontar proved to possess the properties of an active antihypoxia agent. Its administration during the last third of pregnancy stimulated the organism's protective-adaptational reactions, increased the resistance of pregnant, rats and the newborns to hypoxia. Limontar significantly improves the mechanometabolic indices of an isolated perfused heart under hypoxic conditions. Analysis of the obtained data suggests that limontar increases energy formation in the myocardium through activation of a more efficient and energetically beneficial path of succinic acid oxidation.
Korneev
A A
AA
Komissarova
I A
IA
Chirkova
E M
EM
Koppel'
M A
MA
Popova
O A
OA
Sheveleva
G A
GA
Filimonov
V G
VG
D000208:Acute Disease; D000818:Animals; D000831:Animals, Newborn; D001273:Atmosphere Exposure Chambers; D002951:Citrates / Q000494:pharmacology / Q000627:therapeutic use; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D005260:Female; D006321:Heart / Q000187:drug effects; D000860:Hypoxia / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism; D009584:Nitrogen; D010100:Oxygen; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D051381:Rats; D013386:Succinates / Q000494:pharmacology / Q000627:therapeutic use
D002951:Citrates; D004338:Drug Combinations; D013386:Succinates; C100829:limontar; C041364:nitrox; D009584:Nitrogen; D010100:Oxygen