title: Synthesis, antiviral and antiproliferative activity of a new class of 5-(alkyl or arylthio)-6-vinyl uracils.
abstract: Uracil derivatives bearing substituted or unsubstituted vinyl groups at position C6 and alkyl- or arylthio groups at position C5 were synthesized and tested in vitro for antiviral and antiproliferative activity. None of the compounds were active against HIV-1. However, some of them inhibited the proliferation of leukemia, lymphoma and solid tumor-derived cell lines at micromolar concentrations. The maximum potency of antiproliferative activity correlates with the presence of unsubstituted vinyl groups and alkyl- or arylthio substituents.
authors.forename: P G
authors.initials: PG
authors.lastname: Baraldi
authors.forename: B
authors.initials: B
authors.lastname: Cacciari
authors.forename: R
authors.initials: R
authors.lastname: Romagnoli
authors.forename: G
authors.initials: G
authors.lastname: Spalluto
authors.forename: L
authors.initials: L
authors.lastname: Garuti
authors.forename: M
authors.initials: M
authors.lastname: Roberti
authors.forename: A
authors.initials: A
authors.lastname: Pani
authors.forename: G
authors.initials: G
authors.lastname: Perra
authors.forename: F
authors.initials: F
authors.lastname: Scintu
authors.forename: N
authors.initials: N
authors.lastname: Pinna
authors.forename: C
authors.initials: C
authors.lastname: Musiu
authors.forename: P
authors.initials: P
authors.lastname: La Colla
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D013873:Thionucleotides / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014498:Uracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D014753:Vinyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D013873:Thionucleotides; D014753:Vinyl Compounds; D014498:Uracil