title: Immunomodulatory activities of Cedrela lilloi and Trichilia elegans aqueous leaf extracts.
abstract: The effects of Cedrela lilloi and Trichilia elegans (Meliaceae) aqueous leaf extracts on several parameters of the mouse immune system were studied. Both extracts showed a strong anticomplementary activity and inhibited the phagocytosis of opsonized sheep erythrocytes and the activation of the oxidative metabolism by opsonized zymosan on peritoneal macrophages. The in vitro proliferation of spleen T-lymphocytes was also impaired. Furthermore, treatment of mice with the extracts diminished the delayed-type hypersensitivity response to sheep erythrocytes. These results suggest that both extracts exert a marked immunomodulatory effect on the mouse immune system.
authors.affiliation: Laboratory of Virology, Faculty of Science, University of Buenos Aires, Argentina.
authors.forename: M M
authors.initials: MM
authors.lastname: Nores
authors.forename: M C
authors.initials: MC
authors.lastname: Courrèges
authors.forename: F
authors.initials: F
authors.lastname: Benencia
authors.forename: F C
authors.initials: FC
authors.lastname: Coulombié
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001118:Argentina; D002469:Cell Separation; D003167:Complement Activation / Q000187:drug effects*; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects; D005260:Female; D006968:Hypersensitivity, Delayed / Q000188:drug therapy*; D008213:Lymphocyte Activation / Q000187:drug effects; D017737:Macrophages, Peritoneal / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D009580:Nitroblue Tetrazolium / Q000737:chemistry; D010587:Phagocytosis / Q000187:drug effects*; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves / Q000378:metabolism; D012756:Sheep; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D015054:Zymosan / Q000633:toxicity
chemical_list: D000276:Adjuvants, Immunologic; D010936:Plant Extracts; D009580:Nitroblue Tetrazolium; D015054:Zymosan