title: Apoptosis in the striatum of rats following intraperitoneal injection of 3-nitropropionic acid.
abstract: The present study investigated the mechanism of cellular degeneration within the striatum following administration of the mitochondrial toxin, 3-nitropropionic (3-NP) acid. Internucleosomal fragmentation typical of apoptosis was present in the DNA of cells from the striatum of 3-NP-treated rats. DNA fragmentation was also evident in this region by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling. The data suggest that striatal cells die by apoptosis following administration of 3-NP.
authors.affiliation: Department of Neurological Surgery, School of Medicine, University of California, San Francisco 94143-0651, USA.
authors.forename: S
authors.initials: S
authors.lastname: Sato
authors.forename: G T
authors.initials: GT
authors.lastname: Gobbel
authors.forename: J
authors.initials: J
authors.lastname: Honkaniemi
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: T
authors.initials: T
authors.lastname: Kondo
authors.forename: K
authors.initials: K
authors.lastname: Murakami
authors.forename: M
authors.initials: M
authors.lastname: Sato
authors.forename: J C
authors.initials: JC
authors.lastname: Copin
authors.forename: P H
authors.initials: PH
authors.lastname: Chan
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D053938:DNA Fragmentation / Q000187:drug effects; D004591:Electrophoresis, Polyacrylamide Gel; D006651:Histocytochemistry; D007274:Injections, Intraperitoneal; D008297:Male; D017072:Neostriatum / Q000166:cytology* / Q000187:drug effects; D009498:Neurotoxins / Q000008:administration & dosage / Q000494:pharmacology*; D009574:Nitro Compounds; D011422:Propionates / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009498:Neurotoxins; D009574:Nitro Compounds; D011422:Propionates; C015392:3-nitropropionic acid