title: Reliability of data from proxy respondents in an international case-control study of cardiovascular disease and oral contraceptives. World Health Organization Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception.
abstract: OBJECTIVE
  To evaluate the reliability of data supplied in a case-control study by proxy respondents for cases who were too ill to do so themselves.
  
  
  METHODS
  A hospital based, case-control study of the current use of oral contraceptives (OC) and cardiovascular diseases. Data from "true" controls matched to a subset of cases were compared with those supplied by proxy respondents about the true controls.
  
  
  METHODS
  Hospitals in 21 centres from Africa, Asia, Europe, and Latin America.
  
  
  METHODS
  For a subset of cases, 403 pairs of controls-one "true" and one proxy-were interviewed. "True" controls were matched by age, place, and time of admission and were admitted with 1 of 27 permissible diagnoses not associated with OC use. Proxy controls were either relatives or friends of true controls.
  
  
  RESULTS
  Levels of concordance between data from proxy and true controls were high for most variables regarding recent events, including current OC use, but were greatly diminished when detailed information, particularly from the past, was required. Husbands were usually the best proxy, although this was question-specific. The sensitivity and specificity of proxy responses were 93% (95% confidence intervals: 77%, 99%) and 100% (98%, 100%) respectively, for current use of OC. Assuming the misclassification of current OC use by proxy cases is similar to that produced by proxy controls, the estimated impact of using proxy data on risk estimates associated with current OC use was to bias the overall estimate of risk of stroke by less than 3% and the risks of both acute myocardial infarction and venous thromboembolism by less than 1%.
  
  
  CONCLUSIONS
  Friends or relatives, and particularly husbands, provided reliable information when used as proxy respondents for young women. The estimated impact of misclassification by proxy respondents on overall risk estimates in the WHO collaborative study was less than that which would have arisen if information from proxy respondents had not been used.
authors.affiliation: Department of Epidemiology and Public Health, University College London Medical School.
authors.forename: N R
authors.initials: NR
authors.lastname: Poulter
authors.forename: C L
authors.initials: CL
authors.lastname: Chang
authors.forename: T M
authors.initials: TM
authors.lastname: Farley
authors.forename: M G
authors.initials: MG
authors.lastname: Marmot
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000209:etiology*; D016022:Case-Control Studies; D003276:Contraceptives, Oral / Q000009:adverse effects*; D003625:Data Collection / Q000379:methods / Q000592:standards*; D005190:Family; D005260:Female; D014943:Global Health; D006801:Humans; D007407:Interviews as Topic; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D003276:Contraceptives, Oral