Brain ischemia and gastric mucosal damage in spontaneously hypertensive rats: the role of arterial vagal adrenoceptors.
Brain ischemia is often accompanied by acute gastric lesions. To clarify the underlying mechanism, the influence of acute ischemic insult to the brain on gastric hemodynamics and mucosal integrity was examined in spontaneously hypertensive rats. One hour after brain ischemia, gastric mucosal blood flow decreased to 71% of the preischemic levels in the control rats but was preserved significantly better, at 94 and 108%, in the prazosin-treated and guanethidine-treated rats, respectively. Vagotomy almost abolished the decrease in gastric mucosal blood flow during cerebral ischemia. Intragastric 0.6 N hydrochloric acid administered just after reperfusion induced more severe hemorrhagic ulcers in the control than in the prazosin-treated and vagotomized groups. These results suggest that noradrenergic neurons acting through alpha1-adrenoceptors contributes to the decrease in gastric mucosal blood flow, and the subsequent disturbed integrity of the gastric mucosa, through the vagal adrenergic pathway during brain ischemia in spontaneously hypertensive rats.
Kawakubo
K
K
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Ibayashi
S
S
Nagao
T
T
Doi
K
K
Aoyagi
K
K
Iida
M
M
Sadoshima
S
S
Fujishima
M
M
D018663:Adrenergic Agents / Q000494:pharmacology; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D001016:Aortic Bodies / Q000502:physiology*; D002560:Cerebrovascular Circulation; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000098:blood supply*; D006145:Guanethidine / Q000494:pharmacology; D002546:Ischemic Attack, Transient / Q000503:physiopathology*; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D011941:Receptors, Adrenergic / Q000502:physiology*; D012039:Regional Blood Flow / Q000187:drug effects; D014628:Vagotomy; D014655:Vascular Resistance / Q000187:drug effects
D018663:Adrenergic Agents; D000317:Adrenergic alpha-Antagonists; D011941:Receptors, Adrenergic; D011224:Prazosin; D006145:Guanethidine