[A comparative pharmacological study of the serotoninergic antidepressants tetrindole and fluoxetin].
Tetrindol, a selective inhibitor of MAOA (predominantly of serotonin oxidase) and fluoxetine, an inhibitor of serotonin neuronal uptake, were studied in psychotropic tests on mice and rats. Both drugs significantly intensified 5-hydroxytriptophan-induced head twitching, reduced the effect of reserpine and the destructive action of maximal electroshock and the scopalamine-induced transient disruption of memory in a test for conditioned response of passive avoidance in rats and mice. In a behavioral swimming test the drugs were less active. In potentiation of 5-HT activity both drugs were approximately equal.
Andreeva
N I
NI
Golovina
S M
SM
Parimbetova
R B
RB
Mashkovskiĭ
M D
MD
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D002227:Carbazoles / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D051381:Rats; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D013997:Time Factors
D000928:Antidepressive Agents; D018687:Antidepressive Agents, Second-Generation; D002227:Carbazoles; D005473:Fluoxetine; D008996:Monoamine Oxidase Inhibitors; D017367:Selective Serotonin Reuptake Inhibitors; C082644:tetrindole