title: Radioprotective effect of whole-body hyperthermia on mice exposed to lethal doses of total-body gamma irradiation.
abstract: The whole-body hyperthermia (40 degrees C, 1 hr) 20-48 hr prior to total-body irradiation (TBI) with 9 Gy gamma rays gave 80% protection as assessed by survival of the animals. However this was reduced to 50% when mice were irradiated 7 or 15 days after hyperthermia. The local hyperthermia (42 degrees C, 1 hr) given prior to irradiation, on the other hand, did not show any protective effect. The whole-body or local hyperthermia given after TBI had no protective effect on survival of animals.
authors.affiliation: Radiation Biology and Biochemistry Division, Bhabha Atomic Research Centre, Bombay, India.
authors.forename: M S
authors.initials: MS
authors.lastname: Patil
authors.forename: G S
authors.initials: GS
authors.lastname: Kaklij
authors.forename: T B
authors.initials: TB
authors.lastname: Poduval
authors.forename: B B
authors.initials: BB
authors.lastname: Singh
mesh_terms: D000818:Animals; D005720:Gamma Rays; D006979:Hyperthermia, Induced; D008297:Male; D051379:Mice; D011836:Radiation Tolerance; D014916:Whole-Body Irradiation