[The effect of calcium channel blockers on the effects of ethanol in the immobilization of mice].
A model of the depressive behavior was used to study the action of the calcium channel blockers combined with ethanol. The ethanol dose used (2 g/kg, per os) caused behavioral changes by the depressive type. From two drugs fendilin (20 mg/kg) and nifedipine (10 mg/kg) showing the antidepressive activity in the test the ethanol effect was counteracted only by the nifedipine. Other drugs, such as cinnarizine (50 mg/kg), verapamil (25 mg/kg), flunarizine, and sabeluzol (10 mg/kg), did not produce a significant effect.
Kozlovskiĭ
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VL
Prakh'e
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D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D012149:Restraint, Physical; D013623:Tail; D013997:Time Factors
D002121:Calcium Channel Blockers; D000431:Ethanol