title: Immunohistological analysis of tumour growth factor beta 1 expression in normal and inflamed salivary glands.
abstract: OBJECTIVE
  To determine whether transforming growth factor-beta 1 (TGF-beta 1) has a pathogenetic role in disease of the salivary glands.
  
  
  METHODS
  An indirect immunohistochemical technique was used to analyse TGF-beta 1 expression in six specimens of normal salivary gland and 23 surgical specimens.
  
  
  RESULTS
  TGF-beta 1 was strongly expressed in the ductal epithelial cells of normal salivary gland tissues (six of six cases) and in inflammatory conditions (eight of 11 cases). In contrast, TGF-beta 1 was not detectable in ductal epithelial cells expressing HLA-DR around infiltrating CD4+ CD45RO+ activated T cells, in the salivary gland tissue of patients with Sjögren's syndrome.
  
  
  CONCLUSIONS
  Because TGF-beta 1 has an essential role in the mucosal immunity of salivary glands, abnormal expression of this cytokine must be regarded as a candidate in the pathogenesis of Sjögren's syndrome.
authors.affiliation: Department of Oral Medicine, Tokyo Dental College, Chiba, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kizu
authors.forename: H
authors.initials: H
authors.lastname: Sakurai
authors.forename: S
authors.initials: S
authors.lastname: Katagiri
authors.forename: N
authors.initials: N
authors.lastname: Shinozaki
authors.forename: M
authors.initials: M
authors.lastname: Ono
authors.forename: K
authors.initials: K
authors.lastname: Tsubota
authors.forename: J
authors.initials: J
authors.lastname: Saito
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D016022:Case-Control Studies; D004848:Epithelium / Q000473:pathology; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D017493:Leukocyte Common Antigens; D008297:Male; D008875:Middle Aged; D012793:Sialadenitis / Q000473:pathology*; D012859:Sjogren's Syndrome / Q000150:complications / Q000473:pathology*; D016212:Transforming Growth Factor beta / Q000032:analysis*
chemical_list: D015415:Biomarkers; D006684:HLA-DR Antigens; D016212:Transforming Growth Factor beta; D017493:Leukocyte Common Antigens