Physiology of chemotherapy-induced emesis and antiemetic therapy. Predictive models for evaluation of new compounds.
The physiology of emesis has been studied for several hundred years, focusing on the different centres involved and the mechanics of expulsion. The vomiting centre receives inputs from various emetic detectors such as the gut, the vestibular labyrinths and the chemoreceptor trigger zone. Emesis is a common disabling effect in motion sickness, postoperative conditions and in radio- and chemotherapy. Our current understanding of the mechanisms has been provided mainly by the recent introduction of serotonin 5-HT3 receptor antagonists into therapeutic use. Nevertheless, despite the considerable advances made in the understanding of the different pathways involved in emesis, there are number of areas that still require experimental investigation. Different animal and human models are available to study the physiology of emesis and to evaluate the antiemetic activity of new compounds, but they need to be predictors of clinical situations.
Veyrat-Follet
C
C
Laboratoire GlaxoWellcome, Unité de Biocinétique, Evereux, France.
Farinotti
R
R
Palmer
J L
JL
D000818:Animals; D000932:Antiemetics / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000009:adverse effects; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D009325:Nausea / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology*; D011237:Predictive Value of Tests; D014839:Vomiting / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology*
D000932:Antiemetics; D000970:Antineoplastic Agents