Body composition in clinically stable men with HIV infection.
Clinically stable HIV-infected men (N = 106) receiving investigational antiretrovirals were recruited. Subjects were divided into three HIV disease severity groups by CD4+ cell count. Standard measures of body composition were assessed, as well as serum measures of visceral protein stores and kilocalorie intake. Group 1 subjects (CD4+ T cells < 200) had significantly lower measures of body fat as compared with Group 2 (CD4 between 200 and 600) and Group 3 (CD4 > 600) despite adequate kilocalorie intake. Group 2 and Group 3 were not significantly different from each other. Our entire cohort had significantly lower muscle mass compared to norms. Our data demonstrate that people with advanced HIV disease have reduced muscle and fat.
Grady
C
C
Clinical Therapeutics Laboratory, National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA.
Ropka
M
M
Anderson
R
R
Lane
H C
HC
D000328:Adult; D001823:Body Composition; D018791:CD4 Lymphocyte Count; D003430:Cross-Sectional Studies; D002149:Energy Intake; D019247:HIV Wasting Syndrome / Q000145:classification / Q000276:immunology / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015596:Nutrition Assessment; D012720:Severity of Illness Index