All-trans-retinoic acid and pseudotumor cerebri.
Pseudotumor cerebri or idiopathic intracranial hypertension is a neurological syndrome characterized by signs and symptoms of intracranial hypertension without clinical and radiological evidence of infective or space occupying lesions. Iatrogenic factors are frequent; in particular, cases of Pseudotumor cerebri associated with all-trans-retinoic acid treatment in acute promyelocytic leukemia (APL) have been frequently described in pediatric patients. We review the literature and give diagnostic and therapeutic guidelines.
Visani
G
G
Institute of Hematology, Seragnoli, University of Bologna, Italy.
Manfroi
S
S
Tosi
P
P
Martinelli
G
G
D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy; D011559:Pseudotumor Cerebri / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D014212:Tretinoin / Q000009:adverse effects* / Q000627:therapeutic use
D014212:Tretinoin