title: Coccoid and spiral Helicobacter pylori differ in their abilities to adhere to gastric epithelial cells and induce interleukin-8 secretion.
abstract: Helicobacter pylori exists as an actively dividing spiral form and a nonculturable, but viable, metabolizing coccoid form. Both forms are present in the stomach, but their relative pathophysiologic significances are unknown. Here we show that the coccoid form of H. pylori, in contrast to the spiral form, binds poorly to gastric epithelial cells and induces little, if any, interleukin-8 secretion by these cells.
authors.affiliation: Department of Medicine, University of California, San Diego, La Jolla 92093, USA. sheri_cole@som-bsb.ucsd.edu
authors.forename: S P
authors.initials: SP
authors.lastname: Cole
authors.forename: D
authors.initials: D
authors.lastname: Cirillo
authors.forename: M F
authors.initials: MF
authors.lastname: Kagnoff
authors.forename: D G
authors.initials: DG
authors.lastname: Guiney
authors.forename: L
authors.initials: L
authors.lastname: Eckmann
mesh_terms: D001422:Bacterial Adhesion; D002455:Cell Division; D002460:Cell Line; D004848:Epithelium / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D005753:Gastric Mucosa / Q000276:immunology / Q000378:metabolism / Q000382:microbiology*; D016480:Helicobacter pylori / Q000166:cytology* / Q000254:growth & development / Q000502:physiology*; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism*
chemical_list: D016209:Interleukin-8