title: Short-term effects of topical testosterone in vulvar lichen sclerosus.
abstract: OBJECTIVE
  To evaluate the systemic and therapeutic effect of topical testosterone treatment in vulvar lichen sclerosus.
  
  
  METHODS
  This prospective clinical, single-arm study included ten postmenopausal women with vulvar lichen sclerosus. Testosterone propionate (0.04 g daily) was administered topically for 4 weeks. Serum androgens (testosterone, free testosterone, androstenedione, dehydroepiandrosterone sulfate) were determined before and after 4 weeks of treatment, and vulvodynia was evaluated by a horizontal visual analogue scale.
  
  
  RESULTS
  Serum levels of total testosterone increased in all patients (P < .01) and exceeded normal range in eight of ten women. Vulvodynia improved in nine of ten patients (paired t test: P < .01). Four of ten patients showed clinical signs of hyperandrogenism (enlargement of the clitoris, alterations of the voice, increase in libido) after 4 weeks of treatment. The only patient without subjective improvement had elevated basal serum androgen levels and showed clinical signs of hyperandrogenism before therapy.
  
  
  CONCLUSIONS
  Topical testosterone is effective in normoandrogenic women with lichen sclerosus. Androgen status should be evaluated before treatment, and dosage should be individualized to avoid virilization and metabolic side effects. Because there is a marked systemic effect, clinical controls and a follow-up with evaluation of serum testosterone levels are recommended. Other steroids should be included in therapeutic decisions.
authors.affiliation: Department of Gynecology and Obstetrics, University of Vienna Medical School-AKH, Austria.
authors.forename: E A
authors.initials: EA
authors.lastname: Joura
authors.forename: H
authors.initials: H
authors.lastname: Zeisler
authors.forename: D
authors.initials: D
authors.lastname: Bancher-Todesca
authors.forename: M O
authors.initials: MO
authors.lastname: Sator
authors.forename: B
authors.initials: B
authors.lastname: Schneider
authors.forename: G
authors.initials: G
authors.lastname: Gitsch
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D018459:Lichen Sclerosus et Atrophicus / Q000188:drug therapy*; D008875:Middle Aged; D011446:Prospective Studies; D013739:Testosterone / Q000008:administration & dosage*; D013997:Time Factors; D014845:Vulvar Diseases / Q000188:drug therapy*
chemical_list: D013739:Testosterone