Effect of seizures and diuretics on the osmolality of the cerebrospinal fluid.
There was a significant increase in the osmolality of the cerebrospinal fluid (CSF) of the anesthetized rats after treatment with 80 mg/kg (but not 39 mg/kg) furosemide and 1 g/kg of mannitol, but not during seizures induced by kainic acid. Furosemide (10 mg/kg) blocked seizure activity by kainic acid, while mannitol (1 g/kg) did not. The results suggest that the antiepileptic effect of furosemide is due to a direct CNS effect not related to a change in CSF osmolality.
Stringer
J L
JL
Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA. janets@bcm.tmc.edu
Pan
E
E
D000758:Anesthesia; D000818:Animals; D002555:Cerebrospinal Fluid / Q000737:chemistry* / Q000187:drug effects; D004232:Diuretics / Q000134:cerebrospinal fluid* / Q000494:pharmacology; D004234:Diuretics, Osmotic / Q000494:pharmacology; D018690:Excitatory Amino Acid Agonists; D005665:Furosemide / Q000494:pharmacology; D007608:Kainic Acid; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D009994:Osmolar Concentration; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000134:cerebrospinal fluid* / Q000139:chemically induced / Q000503:physiopathology
D004232:Diuretics; D004234:Diuretics, Osmotic; D018690:Excitatory Amino Acid Agonists; D008353:Mannitol; D005665:Furosemide; D007608:Kainic Acid