title: Successful management with interferon alpha-2a after prednisone therapy failure in an infant with a giant cavernous hemangioma.
abstract: A giant cavernous hemangioma of the left arm with severe thrombocytopenia and consumptive coagulopathy was observed in a neonate. Initial treatment with prednisone, platelet transfusions, and clotting replacement failed to control the bleedings. The child was then treated with daily subcutaneous infusions of interferon alpha-2a. Coagulopathy rapidly improved and transfusions were drastically reduced. The hemangioma regressed progressively and disappeared after 4 months of treatment.
authors.affiliation: Department of Pediatrics, University La Sapienza, Rome, Italy.
authors.forename: M A
authors.initials: MA
authors.lastname: Castello
authors.forename: G
authors.initials: G
authors.lastname: Ragni
authors.forename: A
authors.initials: A
authors.lastname: Antimi
authors.forename: A
authors.initials: A
authors.lastname: Todini
authors.forename: G
authors.initials: G
authors.lastname: Patti
authors.forename: R
authors.initials: R
authors.lastname: Lubrano
authors.forename: A
authors.initials: A
authors.lastname: Clerico
authors.forename: A
authors.initials: A
authors.lastname: Calisti
mesh_terms: D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D004211:Disseminated Intravascular Coagulation / Q000150:complications / Q000151:congenital; D005260:Female; D005542:Forearm; D006392:Hemangioma, Cavernous / Q000150:complications / Q000151:congenital / Q000628:therapy*; D006801:Humans; D007231:Infant, Newborn; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D011241:Prednisone / Q000627:therapeutic use*; D011994:Recombinant Proteins; D013577:Syndrome; D013909:Thorax; D013921:Thrombocytopenia / Q000150:complications / Q000151:congenital; D017211:Treatment Failure
chemical_list: D018931:Antineoplastic Agents, Hormonal; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011241:Prednisone