title: Intrauterine growth correlation to postnatal growth--influence of risk factors and complications in pregnancy.
abstract: In a population of 616 pregnant women with increased risk of intrauterine growth retardation, we examined the relationship of third trimester fetal growth to maternal and pregnancy risk factors, the infants condition at birth, and postnatal growth. Intrauterine growth velocity was calculated from repeated estimations of fetal weight using ultrasound. Postnatal growth up to 3 months was measured in 313 of the infants. Intrauterine growth velocity was directly correlated to birth weight deviation (R = 0.35, P < 0.0001) and inversely correlated to postnatal growth (R = 0.21, P = 0.0001). Heavy smoking throughout pregnancy was the most pronounced factor associated with loss of fetal growth percentiles (P = 0.006), and it was also associated with postnatal catchup (P = 0.01). Infants who needed neonatal care had significantly lower intrauterine growth velocities compared to the rest of the study group; no correlation was found between intrauterine growth velocity and Apgar scores or umbilical pH. It is concluded that growth retardation in the third trimester can be identified by ultrasound fetometry, and is associated with maladaptation at birth and postnatal catchup. However, the correlations were weak suggesting that deviation at birth reflects, only to a limited degree, acceleration or deceleration of growth in the third trimester.
authors.affiliation: Department of Obstetrics and Gynecology, Herlev Hospital, University of Copenhagen, Denmark.
authors.forename: T
authors.initials: T
authors.lastname: Larsen
authors.forename: G
authors.initials: G
authors.lastname: Greisen
authors.forename: S
authors.initials: S
authors.lastname: Petersen
mesh_terms: D001034:Apgar Score; D001724:Birth Weight / Q000502:physiology; D005314:Embryonic and Fetal Development / Q000502:physiology*; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology* / Q000503:physiopathology; D005500:Follow-Up Studies; D005865:Gestational Age; D006128:Growth / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011263:Pregnancy Trimester, Third / Q000502:physiology; D011446:Prospective Studies; D011897:Random Allocation; D012044:Regression Analysis; D012307:Risk Factors