Aggressive B-cell lymphoma induced by Epstein-Barr virus infection in erythrodermic cutaneous T-cell lymphoma.
The coexistence of two cutaneous non-Hodgkin's lymphomas of different lineage is rare. We report a patient with an indolent erythrodermic cutaneous T-cell lymphoma followed by an aggressive B-cell lymphoma. To our best knowledge, this is the first report describing Epstein-Barr virus-associated B-cell lymphoma in a patient with cutaneous T-cell lymphoma. We suggest that the long-standing cutaneous T-cell lymphoma, as well as the long-term chemotherapy, suppressed host immunity and caused reactivation of latent Epstein-Barr virus.
Kikuchi
A
A
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
Anzai
H
H
Kosuge
H
H
Naka
W
W
Nishikawa
T
T
D005260:Female; D006566:Herpesviridae Infections / Q000150:complications*; D004854:Herpesvirus 4, Human; D006801:Humans; D016867:Immunocompromised Host; D016393:Lymphoma, B-Cell / Q000821:virology*; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000821:virology*; D012878:Skin Neoplasms / Q000276:immunology / Q000821:virology; D014412:Tumor Virus Infections / Q000150:complications*