Relation between amiodarone and desethylamiodarone plasma concentrations and ventricular defibrillation energy requirements.
The main finding of this prospective, controlled study is that amiodarone and desethylamiodarone plasma concentrations < 1 mg/L are associated with a 23% increase in the acute defibrillation energy requirement and with a 31% increase in the requirement for a subcutaneous patch or array. The defibrillation energy requirement does not correlate with the plasma concentrations of amiodarone, desethylamiodarone, amiodarone plus desethylamiodarone, or with the duration or daily dosage of amiodarone therapy.
Daoud
E G
EG
Department of Internal Medicine, University of Michigan, Ann Arbor 48109-0022, USA.
Man
K C
KC
Horwood
L
L
Morady
F
F
Strickberger
S A
SA
D000368:Aged; D000638:Amiodarone / Q000031:analogs & derivatives* / Q000097:blood*; D017147:Defibrillators, Implantable; D004554:Electric Countershock; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
C036116:desethylamiodarone; D000638:Amiodarone