title: [Preparation of fiber materials containing both the immobilized proteolytic enzyme and antimicrobial substance, and study of their properties].
abstract: Properties of joint immobilization of a proteolytic enzyme (terrilytin, trypsin, collytin, or protease C) and an anti-microbe compound to cellulose copolymer containing carboxyl groups were investigated. It was established that the molecule of anti-microbe substance containing a few base groups enhanced stability of the enzyme immobilized, most likely due to additional fixation of the enzyme macromolecule. Changes in activity of the materials containing both protease and anti-microbe compound were studied upon gamma-sterilization and subsequent prolonged storage. The materials with combined biological action were demonstrated to accelerate markedly wound cleansing and healing.
authors.forename: A D
authors.initials: AD
authors.lastname: Virnik
authors.forename: I F
authors.initials: IF
authors.lastname: Skokova
authors.forename: T N
authors.initials: TN
authors.lastname: Iudanova
authors.forename: K P
authors.initials: KP
authors.lastname: Khomiaakov
authors.forename: M V
authors.initials: MV
authors.lastname: Ivanova
authors.forename: A V
authors.initials: AV
authors.lastname: Sedov
authors.forename: P I
authors.initials: PI
authors.lastname: Tolstykh
authors.forename: V K
authors.initials: VK
authors.lastname: Gostintsev
authors.forename: B N
authors.initials: BN
authors.lastname: Arutiunian
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015169:Colony Count, Microbial; D010450:Endopeptidases / Q000737:chemistry / Q000302:isolation & purification*; D004800:Enzymes, Immobilized / Q000737:chemistry / Q000302:isolation & purification*; D006868:Hydrolysis; D013210:Staphylococcus / Q000187:drug effects / Q000254:growth & development; D013242:Sterilization
chemical_list: D000900:Anti-Bacterial Agents; D004800:Enzymes, Immobilized; D010450:Endopeptidases