A human candidate spermatogenesis gene, RBM1, is conserved and amplified on the marsupial Y chromosome.
Three genes, RBM1, DAZ and TSPY, map to a small region of the long arm of the human Y chromosome which is deleted in azoospermic men. RBM1, but not DAZ or TSPY, has a Y-linked homologue in marsupials which is transcribed in the testis. This suggests that RBM1 has been retained on the Y chromosome because of a critical male-specific function. Marsupial RBM1 is closely related to human RBM1, but, like the related autosomal gene hnRNPG, lacks the amplification of an exon. This suggests that RBM1 evolved from hnRNPG at least 130 million years ago and has undergone internal amplification in primates, as well as independent amplification in several therian [corrected] lineages.
Delbridge
M L
ML
School of Genetics and Human Variation, La Trobe University, Bundoora, Victoria, Australia.
Harry
J L
JL
Toder
R
R
O'Neill
R J
RJ
Ma
K
K
Chandley
A C
AC
Graves
J A
JA
D000595:Amino Acid Sequence; D000818:Animals; D018797:Cell Cycle Proteins; D002874:Chromosome Mapping; D004268:DNA-Binding Proteins / Q000235:genetics; D000075364:Deleted in Azoospermia 1 Protein; D019143:Evolution, Molecular; D005784:Gene Amplification; D005796:Genes; D006801:Humans; D008297:Male; D008322:Mammals / Q000235:genetics; D008394:Marsupialia / Q000235:genetics*; D008969:Molecular Sequence Data; D009687:Nuclear Proteins; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000235:genetics*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D051876:Sex-Determining Region Y Protein; D013045:Species Specificity; D013091:Spermatogenesis / Q000235:genetics*; D014157:Transcription Factors; D014998:Y Chromosome / Q000235:genetics* / Q000648:ultrastructure
D018797:Cell Cycle Proteins; C095668:DAZ1 protein, human; D004268:DNA-Binding Proteins; D000075364:Deleted in Azoospermia 1 Protein; D009687:Nuclear Proteins; C501499:RBMY1A1 protein, human; D016601:RNA-Binding Proteins; D051876:Sex-Determining Region Y Protein; C497749:TSPY1 protein, human; D014157:Transcription Factors