Effect of Bordetella bronchiseptica and serotype D Pasteurella multocida bacterin-toxoid on the occurrence of atrophic rhinitis after experimental infection with B. bronchiseptica and toxigenic type AP. multocida.
In efficacy tests, 7 primary specific-pathogen-free piglets vaccinated with the Bordetella bronchiseptica and type D Pasteurella multocida bacterin-toxoid were challenged with B. bronchiseptica and type A P. multocida. Severe or moderate nasal turbinate atrophy was produced in the non-vaccinated pigs, whereas, only one of the 4 pigs in the vaccinated group had slight turbinate atrophy. Other immune sera against crude toxin of P. multocida type A or D were cross neutralized. The results of the present study show that the P. multocida serotype D bacterin-toxoid is effective against atrophic rhinitis caused by toxigenic P. multocida serotype A as well as toxigenic P. multocida serotype D.
Sakano
T
T
Zen-noh Institute of Animal Health, Chiba, Japan.
Okada
M
M
Taneda
A
A
Mukai
T
T
Sato
S
S
D000818:Animals; D001284:Atrophy; D001428:Bacterial Vaccines / Q000494:pharmacology; D001884:Bordetella / Q000276:immunology / Q000302:isolation & purification*; D001885:Bordetella Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D010326:Pasteurella Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D016979:Pasteurella multocida / Q000145:classification / Q000276:immunology / Q000302:isolation & purification*; D012222:Rhinitis, Atrophic / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D012703:Serotyping; D013552:Swine; D013553:Swine Diseases; D014420:Turbinates / Q000187:drug effects / Q000473:pathology
D001428:Bacterial Vaccines; C105672:Pasteurella multocida bacterin-toxoid