Effect of potassium channel modulators on male sexual behavior.
In the adult sexually experienced male rat, the intracerebroventricular (i.c.v.) injection of pinacidil, a KATP channel opener, at the dose of 100-150-300 micrograms/rat worsened the copulatory performance in the presence of a receptive female, whereas the administration of glibenclamide, a KATP channel blocker, at the dose of 0.5 and 3 mg/kg intraperitoneally (i.p.) had an improving effect. These data indicate that KATP channels in target neurons may play an important role in the physiology of male sexual behavior.
Benelli
A
A
Department of Biomedical Sciences, University of Modena, Italy.
Arletti
R
R
Poggioli
R
R
Cavazzuti
E
E
Mameli
M
M
Bertolini
A
A
D000818:Animals; D005260:Female; D005905:Glyburide / Q000008:administration & dosage / Q000494:pharmacology*; D006146:Guanidines / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D020110:Pinacidil; D026902:Potassium Channel Blockers; D015221:Potassium Channels / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D006146:Guanidines; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D020110:Pinacidil; D005905:Glyburide