Pheromone signalling and polarized morphogenesis in yeast.
Yeast cells respond to mating pheromones by activating a signal transduction pathway involving a seven transmembrane receptor/G protein complex linked to a mitogen-activated protein kinase module. Regulation of the G protein signal is controlled by the receptor and Sst2p; Sst2p may function as a GTPase-activating protein for the G protein alpha subunit. The Ste20 kinase acts in the linkage between the G protein and the MAP kinase module. Experiments suggest that binding of the Rho-like GTPase Cdc42p to Ste20p is not required for the mating response, yet is needed for the pseudohyphal growth response which involves many of the same kinases.
Leberer
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NRC Biotechnology Research Institute, 6100 Royalmount Avenue, Montreal Quebec, Canada H4P 2R2.
Thomas
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DY
Whiteway
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D019204:GTP-Binding Proteins / Q000502:physiology; D010675:Pheromones / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000254:growth & development*; D015398:Signal Transduction / Q000502:physiology*
D010675:Pheromones; D019204:GTP-Binding Proteins