The morphology of Candida albicans in two different Earle base media in the presence of tunicamycin.
The effect of tunicamycin on the morphology of Candida albicans yeast cells and germ tubes grown in two different Earle's minimal essential media was investigated. Tunicamycin inhibited germ tube and mycelia formation. Inhibition increased the size and caused aberrant morphology of yeast cells, including bud formation. These cells are hydrophobic and could be used for the production of two monoclonal antibodies suitable for the study of adhesion phenomena as well as ectomural properties.
Vespa
M N
MN
Laboratoire d'Immunologie et Parasitologie, Faculté de Pharmacie, Université de Montpellier I, France.
Lebecq
J C
JC
D000911:Antibodies, Monoclonal; D002176:Candida albicans / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure*; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D003470:Culture Media; D008351:Mannans / Q000032:analysis / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D008969:Molecular Sequence Data; D014415:Tunicamycin / Q000494:pharmacology*
D000911:Antibodies, Monoclonal; D003470:Culture Media; D008351:Mannans; D014415:Tunicamycin