Intestinal metaplasia and dysplastic modifications in H. pylori gastritis.
Certain studies regarding modifications of gastric mucosa in the presence of infections produced by H. pylori add a new element in the pathology of gastric lesions with a high malignancy potential. From the certain premalignant lesions, a special place is occupied by intestinal metaplasia and by gastric dysplasia, because of their high frequency. This study is based upon the interpretation of 130 gastric biopsies in which the identification of H. pylori was pursued (by HE staining, Giemsa), o intestinal metaplasia and their types (by PAS-Blue Alcian ph 2.5 staining and High Iron Diamine-Blue Alcian ph 2.5) and the presence of neoplastic lesions. Particular aspects of our study are given by the association of H. pylori infection with certain types of intestinal metaplasia, with moderate or severe dysplastic lesions and with gastric carcinomas (especially the "intestinal" type).
Tăban
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S
Department of Morphopathology, University of Medicine and Pharmacy, Timişoara.
Tudose
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D005756:Gastritis / Q000382:microbiology / Q000473:pathology*; D016481:Helicobacter Infections / Q000473:pathology*; D016480:Helicobacter pylori; D006801:Humans; D007422:Intestines / Q000473:pathology*; D008679:Metaplasia / Q000473:pathology; D012189:Retrospective Studies