title: Comparative study of the efficacy of lysine acetylsalicylate, indomethacin and pethidine in acute renal colic.
abstract: The aim of this study was to compare the analgesic efficacy of intravenous lysine acetylsalicylate 1.8 g, indomethacin 100 mg and pethidine 100 mg in acute renal colic in a randomized double-blind clinical trial. One hundred and fifty patients with acute renal colic were divided into three groups. The first group received lysine acetylsalicylate 1.8 g, the second group received indomethacin 100 mg and the third group received pethidine 100 mg. The degree of pain relief was recorded 5, 15, 30 and 60 min after intravenous administration of the drugs. There was no statistically significant difference between the degree of analgesia provided by pethidine and indomethacin. Lysine acetylsalicylate was less effective than indomethacin and pethidine. It is concluded that intravenous indomethacin is an effective alternative to intravenous pethidine in the treatment of acute renal colic. Intravenous lysine acetylsalicylate is inferior to intravenous indomethacin in treatment of acute renal colic.
authors.affiliation: Department of Emergency, Mubarak Al-Kabeer Hospital, Kuwait.
authors.forename: K S
authors.initials: KS
authors.lastname: al-Sahlawi
authors.forename: O M
authors.initials: OM
authors.lastname: Tawfik
mesh_terms: D000328:Adult; D000700:Analgesics / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001241:Aspirin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003085:Colic / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D007674:Kidney Diseases / Q000188:drug therapy*; D008239:Lysine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008614:Meperidine / Q000627:therapeutic use*; D008875:Middle Aged; D010147:Pain Measurement; D013997:Time Factors
chemical_list: D000700:Analgesics; D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D008614:Meperidine; D008239:Lysine; D001241:Aspirin; C010395:acetylsalicylic acid lysinate; D007213:Indomethacin