Increased anion gap after liver transplantation.
Massive fibrinolysis after a liver transplant resulted in oliguric renal failure and necessitated the continuous infusion of large quantities of fresh frozen plasma. With the increase in plasma protein concentration, there was a simultaneous increase in the anion gap. These two parameters, the anion gap and total protein or albumin level in the blood, demonstrated a high degree of correlation. Weaker but significant correlations were found in a retrospective analysis of patients with a variety of renal diseases and a population of long-term peritoneal but not hemodialysis patients. This entity of hyperproteinemic acidosis should be added to the list of high anion gap acidoses.
Kirschbaum
B
B
Division of Nephrology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0160, USA.
D000136:Acid-Base Equilibrium / Q000502:physiology*; D001798:Blood Proteins / Q000378:metabolism; D001803:Blood Transfusion; D002245:Carbon Dioxide / Q000097:blood; D002412:Cations / Q000097:blood; D002712:Chlorides / Q000097:blood; D004573:Electrolytes / Q000097:blood*; D005342:Fibrinolysis; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D013223:Statistics as Topic
D001798:Blood Proteins; D002412:Cations; D002712:Chlorides; D004573:Electrolytes; D002245:Carbon Dioxide