title: Serum interleukin-10 in acquired immunodeficiency syndrome lymphoma patients. Seroco-Hemoco Study Group.
abstract: Interleukin-10 (IL-10) has multiple effects on lymphoid development, particularly as a stimulant of activated B-cell proliferation and differentiation. It is thought that IL-10 might play a role in the development of B lymphoid malignancies based on the observation that lymphomatous tissues from HIV+ patients contain numerous cells containing IL-10 mRNA as well as IL-10 protein. The aim of this study using an Elisa test was to analyze IL-10 in the serum of 18 HIV+ patients with non Hodgkin's B lymphoma (NHL) and compared the presence of this cytokine in the serum of 18 HIV+ patients without NHL. In this comparative study we also considered the different parameters such as the mode of contamination, sex, age and number of CD4 cells. 44% of the patients with HIV-related NHL had significant levels of IL-10 (> or = 12 pg/ml) in their serum, in comparison to the patients without NHL who did not show detectable serum IL-10.
authors.affiliation: Institut Pasteur, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Edelman
authors.forename: C
authors.initials: C
authors.lastname: Deveau
authors.forename: M
authors.initials: M
authors.lastname: Raphael
authors.forename: E
authors.initials: E
authors.lastname: Monchatre
authors.forename: J
authors.initials: J
authors.lastname: Gabarre
authors.forename: A
authors.initials: A
authors.lastname: Deville-Chabrol
authors.forename: G
authors.initials: G
authors.lastname: Pialoux
authors.forename: D
authors.initials: D
authors.lastname: Emilie
authors.forename: I
authors.initials: I
authors.lastname: Joab
authors.forename: P
authors.initials: P
authors.lastname: Galanaud
mesh_terms: D000328:Adult; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016679:Genome, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D016483:Lymphoma, AIDS-Related / Q000097:blood* / Q000821:virology; D016393:Lymphoma, B-Cell / Q000097:blood* / Q000821:virology; D008297:Male; D008875:Middle Aged
chemical_list: D016753:Interleukin-10