A characteristic of aspirin-induced hearing loss in auditory brainstem response of conscious rats.
The acute effects of aspirin on auditory functions were examined electrophysiologically in conscious rats with chronically implanted electrodes for auditory brainstem response (ABR) recording. A single intravenous injection of aspirin at a dose of 225 mg/kg caused a reduction in the amplitude of the ABR P1 wave evoked by a 2 kHz tone pip 1 and 24 hr after dosing at almost all sound intensity levels, while the P1 amplitude at 4 kHz was reduced mainly 1 hr after dosing, and the P1 amplitude at 8 kHz was not significantly affected at middle and high intensities even 1 hr after dosing. The audiogram obtained from the P1 amplitude showed a significant increase in the sound threshold 1 and 24 hr after dosing at 2 kHz, and 1 hr after dosing at 4 kHz, but not at 8 kHz. The peak latency of the P1 wave was also prolonged. Furthermore, reduction of the P2 and P4 wave amplitude and prolongation of the P1-P2 and P2-P4 interpeak latency were also observed at 2 kHz but not a 4 or 8 kHz. These results suggest that the rat auditory function for low frequency is vulnerable to the effects of aspirin. This paradigm, i.e., frequency selectivity, n rats may be useful to further assess the different outer hair cells along the cochlear duct and provide additional evidence for the mechanism(s) or site underlying aspirin ototoxicity.
Kurata
K
K
Drug Safety Research Laboratories, Takeda Chemical Industries, Ltd., Osaka, Japan.
Yamamoto
M
M
Tsukuda
R
R
Suzuki
T
T
Sato
S
S
D000161:Acoustic Stimulation; D000818:Animals; D001241:Aspirin / Q000633:toxicity*; D001933:Brain Stem / Q000187:drug effects / Q000503:physiopathology*; D003051:Cochlea / Q000502:physiology / Q000503:physiopathology; D004594:Electrophysiology; D006313:Hearing Loss, Central / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time
D001241:Aspirin