Plasmid virulence gene expression induced by short-chain fatty acids in Salmonella dublin: identification of rpoS-dependent and rpo-S-independent mechanisms.
The Salmonella plasmid virulence spvABCD genes are growth phase regulated and require RpoS for maximal expression in stationary phase. We identified a growth phase-independent expression of spv which is mediated by short-chain fatty acids. During this fatty acid-mediated expression of spv, RpoS is required for induction only during exponential phase. In stationary phase, an rpoS-independent mechanism is responsible for expression of spv.
El-Gedaily
A
A
Department of Medicine, University Hospital of Zurich, Switzerland.
Paesold
G
G
Chen
C Y
CY
Guiney
D G
DG
Krause
M
M
D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D003470:Culture Media; D005232:Fatty Acids, Volatile / Q000494:pharmacology*; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D005809:Genes, Regulator; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics*; D012475:Salmonella / Q000235:genetics* / Q000254:growth & development / Q000472:pathogenicity*; D012808:Sigma Factor / Q000235:genetics / Q000502:physiology*; D014774:Virulence / Q000235:genetics
D001426:Bacterial Proteins; D003470:Culture Media; D005232:Fatty Acids, Volatile; D012808:Sigma Factor; C069567:sigma factor KatF protein, Bacteria