title: Long-term results of lung metastasectomy: prognostic analyses based on 5206 cases.
abstract: OBJECTIVE
  The International Registry of Lung Metastases was established in 1991 to assess the long-term results of pulmonary metastasectomy.
  
  
  METHODS
  The Registry has accrued 5206 cases of lung metastasectomy, from 18 departments of thoracic surgery in Europe (n = 13), the United States (n = 4) and Canada (n = 1). Of these patients, 4572 (88%) underwent complete surgical resection. The primary tumor was epithelial in 2260 cases, sarcoma in 2173, germ cell in 363, and melanoma in 328. The disease-free interval was 0 to 11 months in 2199 cases, 12 to 35 months in 1857, and more than 36 months in 1620. Single metastases accounted for 2383 cases and multiple lesions for 2726. Mean follow-up was 46 months. Analysis was performed by Kaplan-Meier estimates of survival, relative risks of death, and multivariate Cox model.
  
  
  RESULTS
  The actuarial survival after complete metastasectomy was 36% at 5 years, 26% at 10 years, and 22% at 15 years (median 35 months); the corresponding values for incomplete resection were 13% at 5 years and 7% at 10 years (median 15 months). Among complete resections, the 5-year survival was 33% for patients with a disease-free interval of 0 to 11 months and 45% for those with a disease-free interval of more than 36 months; 43% for single lesions and 27% for four or more lesions. Multivariate analysis showed a better prognosis for patients with germ cell tumors, disease-free intervals of 36 months or more, and single metastases.
  
  
  CONCLUSIONS
  These results confirm that lung metastasectomy is a safe and potentially curative procedure. Resectability, disease-free interval, and number of metastases enabled us to design a simple system of classification valid for different tumor types.
authors.forename: U
authors.initials: U
authors.lastname: Pastorino
authors.forename: M
authors.initials: M
authors.lastname: Buyse
authors.forename: G
authors.initials: G
authors.lastname: Friedel
authors.forename: R J
authors.initials: RJ
authors.lastname: Ginsberg
authors.forename: P
authors.initials: P
authors.lastname: Girard
authors.forename: P
authors.initials: P
authors.lastname: Goldstraw
authors.forename: M
authors.initials: M
authors.lastname: Johnston
authors.forename: P
authors.initials: P
authors.lastname: McCormack
authors.forename: H
authors.initials: H
authors.lastname: Pass
authors.forename: J B
authors.initials: JB
authors.lastname: Putnam
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D016019:Survival Analysis