title: Tuberculosis of the long bone in children.
abstract: From 1985 to 1994, there were 24 cases of long bone solitary tuberculosis. They were 18 boys and 6 girls with an average age of 18 months. All of the patients were treated by open biopsy and curettage and antituberculosis therapy (isoniazid and rifampin) for 6 months. Two patients had incomplete administration of the drug therapy. The lesions were in the metaphysis. Epiphyseal involvement was not significant. The tuberculin skin test was negative in 3 children and the culture was negative in 17 cases. After 2 years and 8 months' followup, there was radiographic evidence of good bone remodeling. Although there uncommonly is not a delay in diagnosis of skeletal tuberculosis despite prolonged symptoms, diagnostic biopsy with curettage of the lesion is indicated for isolated lesions, especially when the diagnosis is in doubt. It is significant that surgical debridement can shorten the duration of antituberculosis therapy and lead to improved results.
authors.affiliation: Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan, Republic of China.
authors.forename: H N
authors.initials: HN
authors.lastname: Shih
authors.forename: R W
authors.initials: RW
authors.lastname: Hsu
authors.forename: T Y
authors.initials: TY
authors.lastname: Lin
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use*; D001706:Biopsy; D002675:Child, Preschool; D003475:Curettage; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007538:Isoniazid / Q000008:administration & dosage; D008297:Male; D011859:Radiography; D012293:Rifampin / Q000008:administration & dosage; D014394:Tuberculosis, Osteoarticular / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery*
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid; D012293:Rifampin