title: Liposome-delivered 131I-labelled Zn(II)-phthalocyanine as a radiodiagnostic agent for tumours.
abstract: 131I-Zn(II)-phthalocyanine (ZnPc) incorporated into unilamellar liposomes has been systemically injected to mice bearing a transplanted MS-2 fibrosarcoma. Biodistribution studies show that the pharmacokinetic behaviour of 131I-ZnPc is very similar to that defined for the parent molecule ZnPc including a serum half-life of ca. 12 h, a high recovery from liver and spleen and minimal accumulation in kidney and brain. The most important pharmacokinetic parameter is represented by the high tumour/ muscle ratio of 131I-ZnPc concentration (ca. 9 at 24 h post-injection). These results suggest the possible use of the radiolabelled derivative for a real-time non-invasive monitoring of the ZnPc concentration in the tumour and peritumoural tissue during photodynamic therapy.
authors.affiliation: Dipartimento di Biologia, Università di Padova, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Polo
authors.forename: A
authors.initials: A
authors.lastname: Segalla
authors.forename: G
authors.initials: G
authors.lastname: Jori
authors.forename: G
authors.initials: G
authors.lastname: Bocchiotti
authors.forename: G
authors.initials: G
authors.lastname: Verna
authors.forename: R
authors.initials: R
authors.lastname: Franceschini
authors.forename: R
authors.initials: R
authors.lastname: Mosca
authors.forename: P G
authors.initials: PG
authors.lastname: De Filippi
mesh_terms: D000818:Animals; D005354:Fibrosarcoma / Q000000981:diagnostic imaging / Q000378:metabolism; D007211:Indoles / Q000493:pharmacokinetics*; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D054833:Isoindoles; D008081:Liposomes; D051379:Mice; D008807:Mice, Inbred BALB C; D009132:Muscles / Q000378:metabolism; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D011877:Radionuclide Imaging; D013997:Time Factors; D014018:Tissue Distribution; D014407:Tumor Cells, Cultured; D017967:Zinc Compounds
chemical_list: D007211:Indoles; D007457:Iodine Radioisotopes; D054833:Isoindoles; D008081:Liposomes; D009942:Organometallic Compounds; D017967:Zinc Compounds; C052159:Zn(II)-phthalocyanine