title: Juvenile hemangioma of the testis: analysis of expression of angiogenic factors.
abstract: We present a case of juvenile hemangioma of the testis associated with hemangiomas of the liver and skin. The testicular hemangioma appeared to progress after therapy with interferon alpha-2a (IFN alpha-2a), whereas the liver and skin hemangiomas regressed. Analysis of growth factors responsible for proliferation of hemangioma revealed that the tumor expressed vascular endothelial growth factor but not basic fibroblast growth factor (bFGF), which is reported to be inhibited by IFN alpha-2a. This finding suggests that a possible explanation for the inadequate efficacy of IFN alpha-2a for testicular hemangioma is a lack of bFGF expression.
authors.affiliation: Department of Urology, Sapporo Medical University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Uchida
authors.forename: A
authors.initials: A
authors.lastname: Takahashi
authors.forename: N
authors.initials: N
authors.lastname: Miyao
authors.forename: K
authors.initials: K
authors.lastname: Takeda
authors.forename: H
authors.initials: H
authors.lastname: Tsutsumi
authors.forename: M
authors.initials: M
authors.lastname: Satoh
authors.forename: T
authors.initials: T
authors.lastname: Tsukamoto
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000096:biosynthesis*; D015972:Gene Expression Regulation, Neoplastic; D018324:Hemangioma, Capillary / Q000378:metabolism*; D006801:Humans; D007223:Infant; D008297:Male; D009378:Neoplasms, Multiple Primary; D013736:Testicular Neoplasms / Q000378:metabolism*
chemical_list: D043925:Angiogenesis Inducing Agents