Prediction of diabetes mellitus (NIDDM).
This study was made to analyze predictive NIDDM markers using a long-term GTT follow-up observation period of 1-30 years. Subjects of this study were 5446 cases (3994 males, 1452 females). Results are as follows: (1) NIDDM development rate increased gradually with increasing 2 h-PG levels at GTT, but for groups with 2 h-PG > or = 170 mg/dl, the rate rose rapidly. (2) PG at GTT was higher in the NIDDM development group than in the control group. Mean 1 h-PG reached > or = 200 mg/dl for 4 years before onset in the NIDDM group. Frequency of 1 h-PG > or = 200 mg/dl was 54% 4 years before and 67% 1 year before onset. (3) The highest NIDDM prediction accuracy was in 1 h-PG levels of 200 mg/dl or more and/or 2 h-PG levels of 170 mg/dl or more. Sensitivity was 75.2%, and specificity, 63.4% within 3 years before onset. (4) With addition of delta IRI/delta PG, sensitivity increased, but specificity decreased. (5) The highest relationship with NIDDM development was for high PG levels (1 h-PG > or = 200 mg/dl and/or 2 h-PG > or = 170 mg/dl), the odds ratio being 5.65. The odds ratio of delta IRI/delta PG was lower than ratio of high PG levels. (6) NIDDM development rate increased about 50% in the under-60-years age group and in the group of BMI > or = 25.
Ito
C
C
Hiroshima Atomic Bomb Casualty Council, Health Management Center, Japan.
Maeda
R
R
Nakamura
K
K
Sasaki
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test / Q000379:methods; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000276:immunology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity
D001786:Blood Glucose; D007328:Insulin