NSAID-induced gastrointestinal damage. Epidemiology, risk and prevention, with an evaluation of the role of misoprostol. An Asia-Pacific perspective and consensus.
The problem of nonsteroidal anti-inflammatory drug (NSAID)-induced gastrointestinal toxicity was reviewed by members of the Asia Pacific League of Associations for Rheumatology (APLAR) in a consensus conference in September 1992. This paper by the participants presents the consensus conclusions incorporating knowledge from recent publications. There had been a high level of concern that much of the toxicity had resulted from extensive and indiscriminate prescribing of NSAIDs. The implementation of evidence-based guidelines was considered likely to be able to effect a substantial reduction in toxicity without significant loss of overall therapeutic benefit. The evidence from which such guidelines could be developed is critically appraised.
Champion
G D
GD
St Vincent's Clinic, Sydney, Australia.
Feng
P H
PH
Azuma
T
T
Caughey
D E
DE
Chan
K H
KH
Kashiwazaki
S
S
Liu
H C
HC
Nasution
A R
AR
Nobunaga
M
M
Prichanond
S
S
Torralba
T P
TP
Udom
V
V
Utis
D
D
Wang
S R
SR
Wong
W S
WS
Yang
D J
DJ
Yoo
M C
MC
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D003362:Cost-Benefit Analysis; D004064:Digestive System / Q000187:drug effects*; D006801:Humans; D016595:Misoprostol / Q000494:pharmacology*; D010437:Peptic Ulcer / Q000139:chemically induced / Q000517:prevention & control; D012307:Risk Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D016595:Misoprostol