title: [Subjective diurnal fatigue and sleep deprivation response].
abstract: 29 major depressive patients, the majority suffering from a melancholic subtype and typical diurnal variation of mood, rated subjective tiredness on a 100 mm analogous scale before and after total sleep deprivation (TSD). In study A every four hours during the day before and after TSD and every 2 hours during the TSD-night ratings were performed, in study B at 8.00 a.m. before and after TSD. The mean response rate was 55.2% in the 2 studies. In study A subsequent responders were less tired during the afternoon before TSD. Responding patients were more alert the morning after sleep deprivation than non-responders. A higher inter-individually variability of tiredness ratings in responders before and after sleep deprivation was found in study B, assuming an arousing property and a greater variability in subjective arousal at least during the morning hours. In summary the determination of the subjective arousal level may help to predict response.
authors.affiliation: Klinik für Klinische Psychiatrie und Psychotherapie II, Johann-Wolfgang-Goethe-Universität, Frankfurt am Main, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Volk
authors.forename: S
authors.initials: S
authors.lastname: von Nessen
authors.forename: J
authors.initials: J
authors.lastname: Brandt
authors.forename: K
authors.initials: K
authors.lastname: Georgi
authors.forename: B
authors.initials: B
authors.lastname: Pflug
mesh_terms: D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000523:psychology / Q000628:therapy; D002940:Circadian Rhythm; D003866:Depressive Disorder / Q000523:psychology / Q000628:therapy*; D019263:Dysthymic Disorder / Q000523:psychology / Q000628:therapy; D005221:Fatigue / Q000523:psychology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012892:Sleep Deprivation; D016896:Treatment Outcome