[Stimulation of mitochondrial respiration, induced by laser irradiation in the presence of rhodamine dyes].
The effect of micromolar concentration of rhodamine 123 (methylrhodamine) and ethyl and amyl esters of unsubstituted rhodamine on oxygen consumption by rat liver mitochondria was studied under irradiation by an argon laser (488 and 514 nm). Irradiation of mitochondria in the presence of rhodamine stimulates their respiration. Light-induced stimulation of respiration is not inhibited by free radical scavenger ionol and by inhibitor of the permeability transition pore cyclosporine A. Stimulation of respiration by moderate doses of radiation is reversed in the dark. Increase in radiation dose resulted in only partial reversal of stimulated respiration in the dark. Rhodamine efficacy in stimulation of mitochondrial respiration depends on its structure (amyl > ethyl > methylrhodamine).
Krasnikov
B F
BF
Zorov
D B
DB
D000818:Animals; D007834:Lasers; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D010100:Oxygen / Q000378:metabolism*; D051381:Rats; D020112:Rhodamine 123; D012235:Rhodamines / Q000494:pharmacology*
D012235:Rhodamines; D020112:Rhodamine 123; D010100:Oxygen