title: Group B streptococcus colonization in pregnant diabetic women.
abstract: OBJECTIVE
  To evaluate the influence of maternal diabetes on the risk of group B streptococcus colonization during pregnancy.
  
  
  METHODS
  We prospectively analyzed data on 105 pregnant women with diabetes mellitus, both pregestational and gestational, and a control group of 300 pregnant women without carbohydrate intolerance. All had singleton gestations, negative tests for human immunodeficiency virus, and intact membranes at enrollment. Culture specimens for group B streptococcus were obtained from the lower vaginal walls and rectum. Two-tailed unpaired Student t test, Mann-Whitney U test, and chi 2 test were used as appropriate. Multiple logistic regression analyses were performed to evaluate the independent influence of maternal diabetes on the rate of group B streptococcus colonization.
  
  
  RESULTS
  Compared to controls, diabetic women had a higher colonization rate (43.8 versus 22.7%, odds ratio [OR] 2.56, 95% confidence interval [CI] 1.6, 4.1). The prevalence of group B streptococcus colonization in pregestational diabetic women was 54.1% and in women with gestational diabetes it was 35.1% (P = .05). Among women with pregestational diabetes, the prevalence of group B streptococcus colonization was 59.1% in class B and 50.0% in class C to R (P = not significant). After we adjusted for maternal age, race, and obesity, diabetic women continued to be at increased risk of group B streptococcus colonization (OR 3.1, 95% CI 1.8, 5.2).
  
  
  CONCLUSIONS
  Carbohydrate intolerance appears to be an independent risk factor for group B streptococcus colonization during pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, University of Florida Health Science Center, Jacksonville, USA.
authors.forename: E
authors.initials: E
authors.lastname: Ramos
authors.forename: F L
authors.initials: FL
authors.lastname: Gaudier
authors.forename: L R
authors.initials: LR
authors.lastname: Hearing
authors.forename: G O
authors.initials: GO
authors.lastname: Del Valle
authors.forename: S
authors.initials: S
authors.lastname: Jenkins
authors.forename: D
authors.initials: D
authors.lastname: Briones
mesh_terms: D000328:Adult; D002353:Carrier State / Q000382:microbiology*; D016640:Diabetes, Gestational / Q000382:microbiology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D011237:Predictive Value of Tests; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000382:microbiology*; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013290:Streptococcal Infections / Q000382:microbiology*; D013292:Streptococcus agalactiae / Q000302:isolation & purification*