title: UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. II. Structural elucidation.
abstract: UK-2A, B, C and D, novel antibiotics produced by Streptomyces sp. 517-02, exhibit strong antifungal activity. The structures were elucidated based on spectral and chemical evidence that these compounds are the derivatives of the nine-membered dilactone formed from serine and 4-hydroxypentanoic acid moiety.
authors.affiliation: Faculty of Science, Osaka City University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hanafi
authors.forename: K
authors.initials: K
authors.lastname: Shibata
authors.forename: M
authors.initials: M
authors.lastname: Ueki
authors.forename: M
authors.initials: M
authors.lastname: Taniguchi
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification; D003460:Crystallization; D006860:Hydrogen Bonding; D006868:Hydrolysis; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D008968:Molecular Conformation; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry / Q000302:isolation & purification; D013302:Streptomyces / Q000378:metabolism
chemical_list: D000935:Antifungal Agents; D007783:Lactones; D011725:Pyridines; C101439:UK 2A; C101494:UK 2B; C101495:UK 2C; C101496:UK 2D