Spindle cell carcinoma of the tongue in a long-term survivor of childhood acute lymphoblastic leukemia.
A 25-year-old male previously treated (age 9 years) for acute lymphoblastic leukemia developed a spindle cell carcinoma of the tongue. Possible causes for the development of his second malignancy are discussed. A combination of scatter from cranial irradiation, poor oral hygiene, alcohol consumption, and cigarette smoking is likely to be contributory. Genetic predisposition can never be fully excluded.
Shaw
M P
MP
Department of Paediatric Oncology, Royal Hospital for Sick Children, Edinburgh, Scotland.
Wallace
W H
WH
Eden
O B
OB
D000328:Adult; D002277:Carcinoma / Q000209:etiology*; D002648:Child; D006801:Humans; D008297:Male; D016609:Neoplasms, Second Primary / Q000209:etiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000628:therapy*; D012074:Remission Induction / Q000379:methods; D017741:Survivors; D014062:Tongue Neoplasms / Q000209:etiology*