Adipocyte differentiation is regulated by a prostaglandin liganded to the nuclear peroxisome proliferator-activated receptor.
Adipocyte differentiation and the homeostasis of fat cell number are regulated by a nuclear receptor protein, the peroxisome proliferator-activated receptor (PPAR gamma). The endogenous ligand is thought to be 15-deoxy-delta 12,14-prostaglandin J2-Thiazolidinedione, an antidiabetic drug, closely mimics the action of the prostaglandin, suggesting a regulatory role by the prostaglandin and PPAR gamma both in adipocyte differentiation and in glucose homeostasis.
Wolf
G
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Department of Nutritional Sciences, University of California, Berkeley 94720-3104, USA.
D017667:Adipocytes / Q000166:cytology* / Q000502:physiology; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002460:Cell Line; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology; D009687:Nuclear Proteins / Q000378:metabolism / Q000502:physiology*; D011453:Prostaglandins / Q000378:metabolism / Q000502:physiology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D000077154:Rosiglitazone; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology; D045162:Thiazolidinediones; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*
D007004:Hypoglycemic Agents; D009687:Nuclear Proteins; D011453:Prostaglandins; D018160:Receptors, Cytoplasmic and Nuclear; D013844:Thiazoles; D045162:Thiazolidinediones; D014157:Transcription Factors; D000077154:Rosiglitazone; D005947:Glucose