title: Utilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239.
abstract: We examined chemokine receptors for the ability to facilitate the infection of CD4-expressing cells by viruses containing the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239. Expression of either human or simian C-C chemokine receptor CCR5 allowed the SIVmac239 envelope glycoproteins to mediate virus entry and cell-to-cell fusion. Thus, distantly related immunodeficiency viruses such as SIV and the primary human immunodeficiency virus type 1 isolates can utilize CCR5 as an entry cofactor.
authors.affiliation: Division of Human Retrovirology, Dana-Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: L
authors.initials: L
authors.lastname: Marcon
authors.forename: H
authors.initials: H
authors.lastname: Choe
authors.forename: K A
authors.initials: KA
authors.lastname: Martin
authors.forename: M
authors.initials: M
authors.lastname: Farzan
authors.forename: P D
authors.initials: PD
authors.lastname: Ponath
authors.forename: L
authors.initials: L
authors.lastname: Wu
authors.forename: W
authors.initials: W
authors.lastname: Newman
authors.forename: N
authors.initials: N
authors.lastname: Gerard
authors.forename: C
authors.initials: C
authors.lastname: Gerard
authors.forename: J
authors.initials: J
authors.lastname: Sodroski
mesh_terms: D000818:Animals; D001483:Base Sequence; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D004279:DNA, Viral; D015686:Gene Products, env / Q000235:genetics / Q000276:immunology*; D006367:HeLa Cells; D006801:Humans; D008969:Molecular Sequence Data; D019713:Receptors, CCR5; D018121:Receptors, Cytokine / Q000276:immunology*; D015728:Receptors, HIV / Q000276:immunology*; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification / Q000502:physiology*
chemical_list: D004279:DNA, Viral; D015686:Gene Products, env; D019713:Receptors, CCR5; D018121:Receptors, Cytokine; D015728:Receptors, HIV