title: Progress towards an alanine/ESR therapy level reference dosimetry service at NPL.
abstract: This paper describes work being carried out at the National Physical Laboratory towards the establishment of an alanine reference dosimetry service for radiotherapy applications. A precision fused quartz holder has been constructed to allow precise positioning of alanine dosimeters in the ESR cavity. A novel method of signal analysis based on spectrum fitting has been developed to minimize the effect of baseline distortions. Data are also presented on the relative response of alanine to 60Co gamma rays and high energy photons (4-12 MeV).
authors.affiliation: National Physical Laboratory, Teddington, Middlesex, U.K.
authors.forename: P H
authors.initials: PH
authors.lastname: Sharpe
authors.forename: K
authors.initials: K
authors.lastname: Rajendran
authors.forename: J P
authors.initials: JP
authors.lastname: Sephton
mesh_terms: D000409:Alanine / Q000737:chemistry / Q000528:radiation effects*; D004578:Electron Spin Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D005609:Free Radicals / Q000032:analysis / Q000528:radiation effects; D005720:Gamma Rays; D006801:Humans; D017785:Photons; D011874:Radiometry / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy; D012015:Reference Standards
chemical_list: D005609:Free Radicals; D000409:Alanine