Intra-septal infusions of glucose potentiate inhibitory avoidance deficits when co-infused with the GABA agonist muscimol.
This experiment examined the effects of co-infusions of glucose with the gamma-aminobutyric acid (GABA) agonist muscimol into the medial septum on memory for inhibitory avoidance learning. Co-infusions of muscimol (3 nmol) and glucose (33 nmol) impaired memory, but neither drug did so when administered alone. Thus, although glucose typically reverses memory deficits, these results indicate that glucose potentiates the memory-impairing effects of a GABA agonist.
Parent
M B
MB
Department of Psychology, University of Virginia, Charlottesville 22903, USA. mparent@psych.ualberta.ca
Gold
P E
PE
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001921:Brain; D004357:Drug Synergism; D018755:GABA Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D007267:Injections; D008297:Male; D008568:Memory / Q000187:drug effects; D009118:Muscimol / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D018755:GABA Agonists; D009118:Muscimol; D005947:Glucose