Pancreatic ductal changes in HIV-infected patients.
BACKGROUND
AIDS-related sclerosing cholangitis occurs in patients with advanced immunodeficiency, but ductal pancreatic alterations have not been evaluated in large series.


METHODS
Twenty-nine consecutive patients with a mean age of 33 years underwent ERCP for biliary work-up. Complete pancreatography was obtained in 28 patients. Serum levels of amylase were increased in 17 patients prior to ERCP. The mean duration of HIV infection was 6.1 years (range 3 to 10 years).


RESULTS
Fifteen patients (53.6%) had pancreatographic changes classified according to the Cambridge classification (stage 1, 4 cases; stage 2, 7 cases; stage 3, 4 cases). Dilatations, irregularities, short stenoses of the main pancreatic duct, and irregularities of side branches were the most frequent abnormalities. Fourteen of these 15 patients (93.3%) had cholangitis and a CD4 cell count of less than 60 per cubic millimeter. Risk factors for pancreatic damage were similar in patients with and without pancreatographic changes. Opportunistic infection occurred in 14 of 15 patients with pancreatographic changes (candida, cytomegalovirus, cryptosporidia, microsporidia, and mycobacteria).


CONCLUSIONS
Abnormal pancreatographies were found in about half of the HIV-infected patients who underwent ERCP. The pancreatographic features were suggestive of chronic pancreatitis and were closely related to the presence of AIDS-related sclerosing cholangitis.
Barthet
M
M
Department of Gastroenterology and Hepatology, Hopital Sainte-Marguerite, Marseille, France.
Chauveau
E
E
Bonnet
E
E
Petit
N
N
Bernard
J P
JP
Gastaut
J A
JA
Sahel
J
J
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000503:physiopathology; D000328:Adult; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002761:Cholangitis / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010182:Pancreatic Diseases / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D010183:Pancreatic Ducts / Q000000981:diagnostic imaging / Q000473:pathology*; D011379:Prognosis; D012307:Risk Factors