DCC's function takes shape in the nervous system.
Deleted in colorectal cancer (DCC), a candidate tumor-suppressor gene, has recently been found to encode a netrin receptor required for axon guidance in vitro. Mutations in Caenorhabditis elegans and Drosophila genes encoding DCC-related proteins affect axon guidance, and these phenotypes resemble those of mutations in netrin genes. Netrins and their DCC-related receptors thus play an evolutionarily conserved role in midline guidance, and DCC may be required more generally for cellular morphogenesis.
Kolodziej
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PA
823 Light Hall, Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232-0295, USA. kolodzp@ctrvax. vanderbilt.edu
D000595:Amino Acid Sequence; D000818:Animals; D001369:Axons / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000502:physiology*; D000075389:DCC Receptor; D016163:Genes, DCC / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D009424:Nervous System Physiological Phenomena; D011956:Receptors, Cell Surface; D025521:Tumor Suppressor Proteins
D015815:Cell Adhesion Molecules; D000075389:DCC Receptor; C501909:DCC protein, human; D011956:Receptors, Cell Surface; D025521:Tumor Suppressor Proteins