Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23.
We have localized the human homolog of the rabbit vasopressin-activated calcium-mobilizing receptor VACM-1 to a region close to the gene for ataxia telangiectasia ATM on chromosome 11q22-23. We have determined the complete amino acid sequence of the human Hs-VACM-1 protein, which is 780 amino acids long. The human and rabbit sequences are highly conserved, differing at only seven amino acids. Northern analysis of the human gene showed expression in a wide range of human tissues. The Hs-VACM-1 gene has homology with the Caenorhabditis elegans gene Ce-cul-5, a member of a family of cullin genes that are involved in cell cycle regulation and that might, when mutated, contribute to tumor progression.
Byrd
P J
PJ
Stankovic
T
T
McConville
C M
CM
Smith
A D
AD
Cooper
P R
PR
Taylor
A M
AM
D000595:Amino Acid Sequence; D000818:Animals; D002880:Chromosomes, Human, Pair 11; D044842:Cullin Proteins; D015870:Gene Expression; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D011817:Rabbits; D017483:Receptors, Vasopressin / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
C094547:Cul5 protein, rat; D044842:Cullin Proteins; D008565:Membrane Proteins; D017483:Receptors, Vasopressin