Compounds with anti-HIV activity from plants.
Natural products are described which have shown activity against human immunodeficiency virus in vitro. These compounds have a variety of chemical structures and modes of action. The discovery of these compounds and features of their development are used to illustrate aspects of the wider use of natural products as novel pharmaceutical agents. Several compounds detailed are being tested clinically and may provide new leads for viral chemotherapy. The use of extracts with isolated constituents is also discussed.
Houghton
P J
PJ
Department of Pharmacy, King's College, London, UK.
D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D017322:Clinical Trials, Phase II as Topic; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006678:HIV / Q000187:drug effects; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal
D019380:Anti-HIV Agents; D010936:Plant Extracts