Self-regenerating bone implant: ectopic osteoinduction following intramuscular implantation of a combination of rhBMP-2, atelopeptide type I collagen and porous hydroxyapatite.
A combination of recombinant human bone morphogenetic protein-2 (rhBMP-2), atelopeptide Type I collagen (CL) as a carrier and porous hydroxyapatite (pHAP) was implanted in a calf muscle pouch of the rat. Three rhBMP-2-implanted groups (2, 10 and 50 micrograms; each n = 5) and the control group (n = 5), in which only CL and pHAP were implanted, were established. Three weeks later, the implants were examined.
Kusumoto
K
K
Department of Plastic and Reconstructive Surgery, Kansai Medical University, Osaka, Japan.
Bessho
K
K
Fujimura
K
K
Konishi
Y
Y
Ogawa
Y
Y
Iizuka
T
T
D000818:Animals; D001672:Biocompatible Materials; D001853:Bone Marrow / Q000473:pathology; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000627:therapeutic use*; D003094:Collagen / Q000627:therapeutic use*; D004337:Drug Carriers; D017886:Durapatite; D004912:Erythrocytes / Q000473:pathology; D006801:Humans; D008297:Male; D008648:Mesoderm / Q000473:pathology; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D010006:Osteoblasts / Q000473:pathology; D010012:Osteogenesis; D016062:Porosity; D011859:Radiography; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*
C525718:BMP2 protein, human; D001672:Biocompatible Materials; C525720:Bmp2 protein, rat; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes; D004337:Drug Carriers; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C059821:atelocollagen; C499469:recombinant human bone morphogenetic protein-2; D003094:Collagen; D017886:Durapatite