Regulation of transcription of MHC class II genes.
Genetic and biochemical analyses have identified multiple DNA-binding and non-DNA-binding proteins that functionally regulate MHC class II genes. These include RFX, X2BP, NF-Y, CIITA, OCT-2 and Bob1. One of the essential non-DNA-binding proteins, CIITA, appears to function as a limiting molecular switch that is responsible for the control of class II expression and the regulation of expression by interferon-gamma.
Boss
J M
JM
Department of Microbiology and Immunology, Emory University School of Medicine, 3131 Rollins Research Center, Atlanta, GA 30322, USA. boss@microbio.emory.edu
D005786:Gene Expression Regulation / Q000276:immunology*; D005802:Genes, MHC Class II / Q000276:immunology*; D006801:Humans; D014158:Transcription, Genetic / Q000276:immunology*