The possibility of predicting tissue accumulation after repeated dosing using a single-dose tissue distribution study.
Mizojiri
K
K
Department of Drug Metabolism and Disposition, Shionogi & Co., Ltd., Osaka, Japan.
Shindo
H
H
Ohno
Y
Y
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D064420:Drug-Related Side Effects and Adverse Reactions; D011237:Predictive Value of Tests; D051381:Rats; D018570:Risk Assessment; D014018:Tissue Distribution; D018675:Toxicity Tests / Q000592:standards* / Q000706:statistics & numerical data