Effectiveness of shakuyaku-kanzo-to in neuroleptic-induced hyperprolactinemia: a preliminary report.
We investigated the efficacy of Shakuyaku-kanzo-to (TJ-68) in neuroleptic-induced hyperprolactinemia in 11 treated schizophrenic patients. The mean plasma prolactin level decreased significantly from 28.9 +/- 14.5 ng/mL at baseline to 22.0 +/- 15.2 ng/mL at 4 weeks. Potassium levels did not change significantly. Neither the exacerbation of psychosis nor other adverse effects occurred.
Yamada
K
K
Department of Neuropsychiatry, Keio University, School of Medicine, Tokyo, Japan.
Kanba
S
S
Murata
T
T
Fukuzawa
M
M
Terashi
B
B
Yagi
G
G
Asai
M
M
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006035:Glycyrrhiza; D006801:Humans; D006966:Hyperprolactinemia / Q000139:chemically induced* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D029596:Paeonia; D011388:Prolactin / Q000097:blood; D012559:Schizophrenia / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014150:Antipsychotic Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C038462:shakuyaku-kanzoh-toh; D011388:Prolactin