title: CCK is involved in both peripheral and central mechanisms controlling food intake in chickens.
abstract: The aim of this work was to study the involvement of cholecystokinin (CCK) in the control of food intake in chickens. The following aspects were studied: 1) the effects of intravenous and intracerebroventricular sulfated octapeptide of CCK (CCK-8s) on voluntary food intake; 2) the effects of two CCK-receptor antagonists. L-365,260 and L-364,718, on food intake; and 3) the ability of such drugs to block the effects of CCK-8s on food intake in the chicken. Intravenous and intracerebroventricular CCK-8s caused a decrease in food intake. Intraperitoneal L-365,260, a CCK-receptor antagonist with low affinity for the two CCK receptors described in the chicken, increases food intake. Intracerebroventricular L-364,718, a drug that has high affinity for the chicken central CCK-receptor type, increased food intake. The effect of intravenous CCK-8s on food intake was not blocked by L-364,718 or L-365,260, whereas that of intracerebroventricular CCK-8s was blocked by intracerebroventricular L-364,718. It is concluded that central endogenous CCK plays a role in the control of food intake, which is dependent on central CCK-receptor type; nevertheless, peripheral CCK also decreases food intake acting on the peripheral CCK-receptor type. The fact that intracerebroventricular L-364,718 is able to increase food intake is related to its high affinity for the central CCK-receptor type of this species. Finally, three different speculations that might explain the fact that intraperitoneal L-365,260 increases food intake are discussed.
authors.affiliation: Department of Cell Biology and Physiology, Veterinary Faculty, Autonomous University of Barcelona, Bellaterra, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez-Sinovas
authors.forename: E
authors.initials: E
authors.lastname: Fernández
authors.forename: X
authors.initials: X
authors.lastname: Manteca
authors.forename: A G
authors.initials: AG
authors.lastname: Fernández
authors.forename: E
authors.initials: E
authors.lastname: Goñalons
mesh_terms: D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D001921:Brain / Q000502:physiology; D002645:Chickens / Q000502:physiology*; D020109:Devazepide; D004435:Eating / Q000187:drug effects*; D006727:Hormone Antagonists / Q000494:pharmacology; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008297:Male; D010671:Phenylurea Compounds; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors / Q000502:physiology; D012844:Sincalide / Q000494:pharmacology*
chemical_list: D001570:Benzodiazepinones; D006727:Hormone Antagonists; D010671:Phenylurea Compounds; D011949:Receptors, Cholecystokinin; C058121:L 365260; D020109:Devazepide; D012844:Sincalide