Recovery from doxacurium infusion administered to produce immobility for more than four days in pediatric patients in the intensive care unit.
Doxacurium was administered by titrated infusion to 14 pediatric patients for 4.7-12.3 days after laryngotracheal reconstruction to produce minimum spontaneous movement and less than five posttetanic movements of the first toe after stimulation of the posterior tibial nerve. Recovery was documented by stimulation of the ulnar nerve with 2 Hz for 2 s (train-of-four [TOF]) at intervals of 1 min and measurement of the ratio of the fourth to the first response (TOF ratio) at the adductor pollicis. During spontaneous recovery, the TOF ratio was between 0.4 and 0.7 for 0.6-3.3 h, mean (SEM) 2.2 (0.31) h. The TOF ratio equaled 1 between 4.7 and 23.0 h, mean (SEM) 11.0 (2.1) h after termination of doxacurium infusion. In six of the patients, weakness and decreased coordination were noted for a few days to weeks postoperatively. There were no complications related to impairment of upper airway function or ventilation in those patients who had recovery of neuromuscular transmission to the extent of TOF ratio equal to 1 prior to extubation or in those patients in whom weakness or lack of coordination was noted after tracheal extubation.
Brandom
B W
BW
Department of Anesthesiology/Critical Care Medicine, Children's Hospital of Pittsburgh, Pennsylvania 15213-2583, USA. BWB@vms.cis.pitt.edu
Yellon
R F
RF
Lloyd
M E
ME
Gronert
B J
BJ
Theroux
M C
MC
Simhi
E
E
Chakravorti
S
S
Venkataraman
S
S
Dohar
J E
JE
Shapiro
A M
AM
Rimell
F L
FL
Reilly
J S
JS
D002648:Child; D002675:Child, Preschool; D004576:Electromyography; D005071:Evoked Potentials; D006801:Humans; D007103:Immobilization; D007223:Infant; D007362:Intensive Care Units; D007442:Intubation, Intratracheal; D007546:Isoquinolines / Q000009:adverse effects / Q000493:pharmacokinetics; D007830:Larynx / Q000601:surgery; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects / Q000493:pharmacokinetics; D009435:Synaptic Transmission / Q000187:drug effects; D013997:Time Factors; D014132:Trachea / Q000601:surgery; D014459:Ulnar Nerve / Q000502:physiology
D007546:Isoquinolines; D003473:Neuromuscular Nondepolarizing Agents; C049429:doxacurium