Cortical NMDAR-1 gene expression is rapidly upregulated after seizure.
The promoter region of the NMDAR-1 receptor has a cis-regulatory element that is capable of binding to the NGFI-A family of transcription factors. Based on this observation, we hypothesized that situations that cause a change in NGFI-A levels would result in a change in NMDAR-1 expression. In these studies, we have demonstrated that a seizure results in a rapid significant increase in NMDAR-1 mRNA and protein expression, at a time when NGFI-A protein levels are expected to be elevated. Our results indicate that control of NMDAR-1 expression is stimulus, time and tissue dependent.
Jensen
P J
PJ
Department of Physiology, University of Wisconsin, Madison 53705, USA.
Millan
N
N
Mack
K J
KJ
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism* / Q000503:physiopathology*; D015870:Gene Expression; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D012640:Seizures / Q000378:metabolism* / Q000503:physiopathology*; D013997:Time Factors; D015854:Up-Regulation / Q000502:physiology*
D016194:Receptors, N-Methyl-D-Aspartate