Liposome-delivered 131I-labelled Zn(II)-phthalocyanine as a radiodiagnostic agent for tumours.
131I-Zn(II)-phthalocyanine (ZnPc) incorporated into unilamellar liposomes has been systemically injected to mice bearing a transplanted MS-2 fibrosarcoma. Biodistribution studies show that the pharmacokinetic behaviour of 131I-ZnPc is very similar to that defined for the parent molecule ZnPc including a serum half-life of ca. 12 h, a high recovery from liver and spleen and minimal accumulation in kidney and brain. The most important pharmacokinetic parameter is represented by the high tumour/ muscle ratio of 131I-ZnPc concentration (ca. 9 at 24 h post-injection). These results suggest the possible use of the radiolabelled derivative for a real-time non-invasive monitoring of the ZnPc concentration in the tumour and peritumoural tissue during photodynamic therapy.
Polo
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Dipartimento di Biologia, Università di Padova, Italy.
Segalla
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A
Jori
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Bocchiotti
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Verna
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Franceschini
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Mosca
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De Filippi
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PG
D000818:Animals; D005354:Fibrosarcoma / Q000000981:diagnostic imaging / Q000378:metabolism; D007211:Indoles / Q000493:pharmacokinetics*; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D054833:Isoindoles; D008081:Liposomes; D051379:Mice; D008807:Mice, Inbred BALB C; D009132:Muscles / Q000378:metabolism; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D011877:Radionuclide Imaging; D013997:Time Factors; D014018:Tissue Distribution; D014407:Tumor Cells, Cultured; D017967:Zinc Compounds
D007211:Indoles; D007457:Iodine Radioisotopes; D054833:Isoindoles; D008081:Liposomes; D009942:Organometallic Compounds; D017967:Zinc Compounds; C052159:Zn(II)-phthalocyanine