title: Local regulation of ileal tone in healthy humans.
abstract: We previously showed that a meal induced, in the human terminal ileum, a delayed tonic relaxation, which could be related to the ileal delivery of meal residues and/or endogenous secretions released by a meal. In this study, we assessed the effects of some components of the ileal contents on its motor activity. In six healthy subjects, we studied ileal tonic and phasic motility in response to the infusion into the terminal ileum of different isotonic solutions: saline, glycochenodeoxycholic acid (GDCA), triglycerides, and short-chain fatty acids (SCFA). Tonic activity was not modified by saline, whereas it was significantly decreased by GDCA and triglycerides (maximal increase in intrabag volume 139 +/- 7% and 152 +/- 16%, respectively, P < 0.01), and significantly increased by SCFA (maximal decrease in intrabag volume 72 +/- 4%, P < 0.01). No significant change of phasic activity was evidenced with either solution. We conclude that 1) bile acids and triglycerides not absorbed in the more proximal gut could be involved in the ileal relaxation occurring after eating and 2) local stimulation of chemoreceptors is of importance in the regulation of ileal motility.
authors.affiliation: Unité de Recherche sur les Fonctions Intestinales, le Métabolisme et la Nutrition, Institut National de la Santé et de la Recherche Médicale U 290, Hôpital Saint-Lazare, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Coffin
authors.forename: M
authors.initials: M
authors.lastname: Lémann
authors.forename: B
authors.initials: B
authors.lastname: Flourié
authors.forename: P
authors.initials: P
authors.lastname: Jouet
authors.forename: J C
authors.initials: JC
authors.lastname: Rambaud
authors.forename: R
authors.initials: R
authors.lastname: Jian
mesh_terms: D000328:Adult; D005232:Fatty Acids, Volatile / Q000494:pharmacology; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D005999:Glycochenodeoxycholic Acid / Q000494:pharmacology; D006801:Humans; D007082:Ileum / Q000187:drug effects / Q000502:physiology*; D008055:Lipids / Q000494:pharmacology; D008297:Male; D009129:Muscle Tonus / Q000187:drug effects / Q000502:physiology*; D012965:Sodium Chloride
chemical_list: D005232:Fatty Acids, Volatile; D008055:Lipids; D012965:Sodium Chloride; D005999:Glycochenodeoxycholic Acid