title: NSAID-induced gastrointestinal damage. Epidemiology, risk and prevention, with an evaluation of the role of misoprostol. An Asia-Pacific perspective and consensus.
abstract: The problem of nonsteroidal anti-inflammatory drug (NSAID)-induced gastrointestinal toxicity was reviewed by members of the Asia Pacific League of Associations for Rheumatology (APLAR) in a consensus conference in September 1992. This paper by the participants presents the consensus conclusions incorporating knowledge from recent publications. There had been a high level of concern that much of the toxicity had resulted from extensive and indiscriminate prescribing of NSAIDs. The implementation of evidence-based guidelines was considered likely to be able to effect a substantial reduction in toxicity without significant loss of overall therapeutic benefit. The evidence from which such guidelines could be developed is critically appraised.
authors.affiliation: St Vincent's Clinic, Sydney, Australia.
authors.forename: G D
authors.initials: GD
authors.lastname: Champion
authors.forename: P H
authors.initials: PH
authors.lastname: Feng
authors.forename: T
authors.initials: T
authors.lastname: Azuma
authors.forename: D E
authors.initials: DE
authors.lastname: Caughey
authors.forename: K H
authors.initials: KH
authors.lastname: Chan
authors.forename: S
authors.initials: S
authors.lastname: Kashiwazaki
authors.forename: H C
authors.initials: HC
authors.lastname: Liu
authors.forename: A R
authors.initials: AR
authors.lastname: Nasution
authors.forename: M
authors.initials: M
authors.lastname: Nobunaga
authors.forename: S
authors.initials: S
authors.lastname: Prichanond
authors.forename: T P
authors.initials: TP
authors.lastname: Torralba
authors.forename: V
authors.initials: V
authors.lastname: Udom
authors.forename: D
authors.initials: D
authors.lastname: Utis
authors.forename: S R
authors.initials: SR
authors.lastname: Wang
authors.forename: W S
authors.initials: WS
authors.lastname: Wong
authors.forename: D J
authors.initials: DJ
authors.lastname: Yang
authors.forename: M C
authors.initials: MC
authors.lastname: Yoo
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D003362:Cost-Benefit Analysis; D004064:Digestive System / Q000187:drug effects*; D006801:Humans; D016595:Misoprostol / Q000494:pharmacology*; D010437:Peptic Ulcer / Q000139:chemically induced / Q000517:prevention & control; D012307:Risk Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D016595:Misoprostol