Sarcoma of bone-cement membrane: a case report and review of the literature.
The development of a cancerous tumour at the site of total joint replacement is a rare but virtually always fatal event. The previously unreported scenario of a patient who was found to have a malignant fibrous histocytoma at the bone-cement membrane after revision for a loose total hip prosthesis is reported. Recent biologic information evaluating the response of mesenchymal cells to metallic debris suggests that the environment surrounding a loosened prosthesis may provide conditions appropriate for the development of a sarcoma.
Bell
R S
RS
Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Ont.
Hopyan
S
S
Davis
A M
AM
Kandel
R
R
Gross
A E
AE
D001707:Biopsy, Needle; D001843:Bone Cements; D002858:Chromium Alloys; D017809:Fatal Outcome; D005260:Female; D005266:Femoral Neoplasms / Q000175:diagnosis / Q000209:etiology*; D006618:Hip Dislocation, Congenital / Q000150:complications / Q000601:surgery; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D020366:Methylmethacrylate; D008768:Methylmethacrylates; D008875:Middle Aged; D009367:Neoplasm Staging; D015207:Osteoarthritis, Hip / Q000209:etiology / Q000601:surgery; D011095:Polyethylenes; D011475:Prosthesis Failure; D012509:Sarcoma / Q000209:etiology*
D001843:Bone Cements; D002858:Chromium Alloys; D008768:Methylmethacrylates; D011095:Polyethylenes; D020366:Methylmethacrylate