Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells.
A lymphocyte population that expresses surface markers found on T cells and natural killer (NK) cells secretes large amounts of interleukin-4 (IL-4) immediately after T cell receptor ligation. These NK-like T cells are thus thought to be important for the initiation of type 2 T helper cell (TH2) responses. CD1-deficient mice were found to lack this lymphocyte subset, but they could nevertheless mount a protypical TH2 response; after immunization with antibody to immunoglobulin D (IgD), CD1-deficient mice produced IgE. Thus, although dependent on CD1 for their development, IL-4-secreting NK-like T cells are not required for TH2 responses.
Smiley
S T
ST
Department of Cancer Biology, Harvard School of Public Health (HSPH), Boston, MA 02115, USA.
Kaplan
M H
MH
Grusby
M J
MJ
D000818:Animals; D000906:Antibodies / Q000276:immunology; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D018949:Antigens, CD1 / Q000235:genetics / Q000502:physiology*; D017252:CD3 Complex / Q000276:immunology; D002478:Cells, Cultured; D018390:Gene Targeting; D007072:Immunoglobulin D / Q000276:immunology; D007073:Immunoglobulin E / Q000096:biosynthesis*; D016130:Immunophenotyping; D007371:Interferon-gamma / Q000235:genetics / Q000378:metabolism; D015847:Interleukin-4 / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D007694:Killer Cells, Natural / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology; D001613:beta 2-Microglobulin / Q000235:genetics / Q000502:physiology
D000906:Antibodies; D000888:Antibodies, Anti-Idiotypic; D018949:Antigens, CD1; D017252:CD3 Complex; D007072:Immunoglobulin D; D012333:RNA, Messenger; D011948:Receptors, Antigen, T-Cell; D001613:beta 2-Microglobulin; D015847:Interleukin-4; D007073:Immunoglobulin E; D007371:Interferon-gamma