Intracisternal papaverine administration associated with acute onset of hyperthermia and metabolic acidosis in a craniotomy.
A case in which the administration of intracisternal papaverine at the end of a craniotomy for aneurysm produced a constellation of signs suggestive of malignant hyperthermia is presented. The published literature on this subject is reviewed.
McLoughlin
A L
AL
Department of Anesthesiology, University of Michigan, Ann Arbor, USA.
D000138:Acidosis / Q000139:chemically induced*; D000328:Adult; D017130:Angioplasty; D002339:Carotid Arteries / Q000601:surgery; D002533:Cerebral Angiography; D002536:Cerebral Arteries / Q000601:surgery; D002544:Cerebral Infarction / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy; D003399:Craniotomy; D004569:Electroencephalography; D006801:Humans; D002532:Intracranial Aneurysm / Q000601:surgery*; D002546:Ischemic Attack, Transient / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy; D008297:Male; D008305:Malignant Hyperthermia / Q000209:etiology*; D016343:Monitoring, Intraoperative; D010208:Papaverine / Q000008:administration & dosage / Q000009:adverse effects*; D013346:Subarachnoid Space; D014057:Tomography, X-Ray Computed; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000009:adverse effects*
D014665:Vasodilator Agents; D010208:Papaverine