Cytokines and their effects on maturation, differentiation and migration of dendritic cells.
In this review the role of cytokines in the maturation and migration of phenotypically and functionally diverse dendritic cell (DC) subpopulations is discussed and their role in progress of differentiation from bone marrow progenitors to lymphoid DC is described. GM-CSF is the most important cytokine for the development of functional DC and acts in concert with a varying mixture of other cytokines such as IL-4, IL-1 and TNF-alpha to direct the development of individual DC subpopulations.
Jonuleit
H
H
Department of Dermatology, University of Mainz, Germany.
Knop
J
J
Enk
A H
AH
D000818:Animals; D017951:Antigen Presentation; D000954:Antigens, Surface / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects / Q000276:immunology; D002465:Cell Movement / Q000187:drug effects / Q000276:immunology; D016207:Cytokines / Q000494:pharmacology / Q000502:physiology*; D003713:Dendritic Cells / Q000166:cytology* / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007801:Langerhans Cells / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D008221:Lymphoid Tissue / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects / Q000276:immunology
D000954:Antigens, Surface; D016207:Cytokines