A structural model for 30 Rh D epitopes based on serological and DNA sequence data from partial D phenotypes.
Both cDNA RHD sequences and reactivity with monoclonal anti-D have been reported in a number of partial D phenotypes, where parts (some epitopes) of the normal D antigen are missing, and anti-D of restricted specificity may be made in response to challenge with normal D positive blood. This paper analyses these reports together and proposes a model for the structure which comprise the epitopes of the Rh D antigen. Some epitopes are proposed to be comprised of continuous peptide sequence within one extracellular loop, whereas others require interactions between two or the extracellular peptide loops.
Scott
M L
ML
IBGRL, Bristol, UK.
Voak
D
D
Jones
J W
JW
Avent
N D
ND
Liu
W
W
Hughes-Jones
N
N
Sonneborn
H
H
D004247:DNA; D000939:Epitopes; D006801:Humans; D008958:Models, Molecular; D010641:Phenotype; D017434:Protein Structure, Tertiary; D012204:Rh-Hr Blood-Group System / Q000235:genetics* / Q000276:immunology; D012699:Serology
D000939:Epitopes; D012204:Rh-Hr Blood-Group System; D004247:DNA