Haliclostanone sulfate and halistanol sulfate from an Indo-Pacific Haliclona sponge.
Two steroids, haliclostanone sulfate (1) and halistanol sulfate (3), were isolated from a Haliclona sp. marine sponge. The structure of the new compound 1 was established based on its spectroscopic data and the properties of a pentaacetate derivative 2. Compound 1 is unique in that it possesses the rare cis C/D ring junction precedented only in marine sterols, contignasterol (4) and xestobergsterols A (5), B (6), and C (7).
Sperry
S
S
Department of Chemistry and Biochemistry, University of California, Santa Cruz 95064, USA.
Crews
P
P
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D010140:Pacific Ocean; D011161:Porifera / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification*; D013463:Sulfuric Acid Esters / Q000737:chemistry / Q000302:isolation & purification*
D013261:Sterols; D013463:Sulfuric Acid Esters; C104551:haliclostanone sulfate; C072244:halistanol trisulfate; D004875:Ergosterol