Inhaled low-dose nitric oxide for postoperative care in patients with congenital heart defects.
Postoperative pulmonary hypertensive crisis is a major problem that may account for a substantial part of the postoperative mortality and morbidity. We, therefore, evaluated the effect of inhalation of low-dose nitric oxide (NO) on postoperative care in pediatric patients with pulmonary hypertension. We studied 10 infants and children ages 1-108 months (median age, 11 months) with congenital heart disease associated with pulmonary hypertension. The NO and N2 gas mixture was then mixed with varied quantities of air and oxygen and delivered into a respirator instead of an inspiratory tube. Patients were treated with inhaled NO for 38.6 +/- 19.6 h (range 1-200 h). All patients were eventually weaned from high level sedation and respirator. The NO concentration ranged from 2 to 5 parts per million. During NO inhalation patients demonstrated a statistically significant reduction in systolic pulmonary arterial pressure by approximately 26%; from 55 +/- 10 to 41 +/- 20 mm Hg. Inhalation of NO resulted in a significant increase of Pao2 from 110 +/- 16 to 149 +/- 29 mm Hg. A-aDo2 significantly decreased from 284 +/- 27 to 247 +/- 31 mm Hg. In conclusion, we have shown that a low-dose NO inhalation acted as pulmonary vasodilator in patients with preexisting pulmonary hypertension.
Shimpo
H
H
Department of Thoracic and Cardiovascular Surgery, Mie University, School of Medicine, Japan.
Mitani
Y
Y
Tanaka
J
J
Mizumoto
T
T
Onoda
K
K
Tani
K
K
Yuasa
H
H
Yada
I
I
Maruyama
K
K
D000280:Administration, Inhalation; D002315:Cardiopulmonary Bypass; D002648:Child; D004305:Dose-Response Relationship, Drug; D006330:Heart Defects, Congenital / Q000150:complications / Q000601:surgery*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D007223:Infant; D007231:Infant, Newborn; D008163:Luminescent Measurements; D009569:Nitric Oxide / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D009584:Nitrogen / Q000008:administration & dosage / Q000627:therapeutic use; D010100:Oxygen / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D011182:Postoperative Care; D011183:Postoperative Complications / Q000517:prevention & control; D014655:Vascular Resistance / Q000187:drug effects
D006454:Hemoglobins; D009569:Nitric Oxide; D009584:Nitrogen; D010100:Oxygen