[Monoclonal antibodies and transplantation].
Several monoclonal antibodies have been evaluated in allograft transplantation, these past years, without being able, to date, to replace polyclonal antibodies. They are classified in four families, each having an individual interest: antibody directed against the CD3/T receptor complex; anti-interleukine II receptor antibodies, specifically blocking activated T lymphocytes; antibodies against adhesion molecules, mainly LFA1 and ICAM1, that, by preventing the reperfusion injury syndrome, should have many clinical applications in the future; antibodies against co-receptor molecules, such as CD4, inducing indefinite allograft tolerance in models of transplantation in rodents, that could be reproducible in human.
Hourmant
M
M
Service de néphrologie et d'immunologie clinique, INSERM U437, Hôtel-Dieu, Nantes.
D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D017252:CD3 Complex / Q000276:immunology; D015704:CD4 Antigens / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000276:immunology; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D016377:Organ Transplantation; D015375:Receptors, Interleukin-2 / Q000276:immunology
D000911:Antibodies, Monoclonal; D017252:CD3 Complex; D015704:CD4 Antigens; D015815:Cell Adhesion Molecules; D015375:Receptors, Interleukin-2