[Tumor-associated and acute-phase proteins in the diagnosis of cancerous exudative pleurisy].
The examination of 150 patients with pleural exudate of different origin (43 cases of malignant and 107 cases of benign genesis) was made to elucidate diagnostic value of immunochemical serum and pleural fluid estimation of four tumor-associated proteins: carcinoembryonic antigen (CEA), beta 2-microglobulin (beta 2-MG), placental alkaline phosphatase (PAP), ferritin; three acute-phase proteins: C-reactive protein (CRP), lactoferrin, fibrin degradation products (FDP); expression of epithelial membrane antigen (EMA) in e date cells using monoclonal antibodies ICO-25. Determination CEA, beta 2-MG in the serum and pleural fluid, antituberculous an bodies in biological fluids proved diagnostically valuable for verification of pleural exudate characteristics. The discriminant analysis provided formulas for this differential diagnosis. The method identification in pleural fluid of cells expressing EMA with the use of monoclonal antibodies ICO-25 was found to be 2 times more efficient in detection of cancer cells than the standard light microscopy.
Uklistaia
T A
TA
Trubnikov
G A
GA
Sukharev
A E
AE
D000209:Acute-Phase Proteins / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006876:Hydrothorax / Q000175:diagnosis; D007150:Immunohistochemistry; D008297:Male; D009363:Neoplasm Proteins / Q000032:analysis*; D016066:Pleural Effusion, Malignant / Q000737:chemistry / Q000175:diagnosis*; D010998:Pleurisy / Q000175:diagnosis; D012680:Sensitivity and Specificity; D014396:Tuberculosis, Pleural / Q000175:diagnosis
D000209:Acute-Phase Proteins; D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins