Ceftibuten concentrations in human tonsillar tissue.
In a study designed to determine ceftibuten concentrations in tonsillar tissue, subjects scheduled to undergo tonsillectomy were administered 400 mg of ceftibuten in a single oral dose. Between 2 and 24 h after the dose was given, tonsillar tissue samples were taken during surgery and assayed for ceftibuten. Mean concentrations in tonsillar tissue 4.4 h and 24.6 h after the 400 mg dose were 5.3 +/- 2.7 and 0.3 +/- mg/g, respectively. Concurrent mean serum concentrations were 7.42 +/- 1.66 and 0.15 +/- 0.13 mg/ml, respectively. The apparent half-life of drug in the tissue was 5.3 h. The presence of high ceftibuten concentrations in tonsillar tissue suggests that a once-daily regimen may be effective in treating tonsillitis and pharyngitis.
Scaglione
F
F
Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Università Degli Studi di Milano, Italy.
Pintucci
J P
JP
Demartini
G
G
Dugnani
S
S
D000293:Adolescent; D000328:Adult; D000077722:Ceftibuten; D002511:Cephalosporins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006207:Half-Life; D006801:Humans; D008297:Male; D014066:Palatine Tonsil / Q000187:drug effects*; D010612:Pharyngitis / Q000188:drug therapy; D014068:Tonsillectomy; D014069:Tonsillitis / Q000188:drug therapy
D002511:Cephalosporins; D000077722:Ceftibuten