Biological activity of maleic anhydride copolymers. I. Biocompatibility and antitumoural effects of maleic anhydride-vinyl acetate, maleic anhydride-methyl methacrylate and maleic anhydride-styrene copolymers.
A series of maleic anhydride (MA)-vinyl acetate (VA), MA-methyl methacrylate (MM), and MA-styrene (S) copolymers were prepared and characterized. On employing various amounts of initiator, maleic anhydride-vinyl acetate, methyl methacrylate, and styrene copolymers with molecular weights ranging between 18,000 and 200,000 have been obtained. The in vivo and in vitro tests performed on K562 cellular cultures (human chronic myeloid leukemia) have shown that, as a function of the molecular weight, the synthesized copolymers demonstrate a 50% in vitro cytotoxicity and an average tumour regression of maximum 68%.
Uglea
C V
CV
Institute of Biological Research, Jassy, Romania.
Panaitescu
L
L
Spridon
D
D
Ursu
D
D
Popa
I
I
Ottenbrite
R M
RM
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D002279:Carcinoma 256, Walker / Q000188:drug therapy; D016923:Cell Death / Q000187:drug effects; D006801:Humans; D008297:Male; D008298:Maleates / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D008299:Maleic Anhydrides / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D008422:Materials Testing; D008768:Methylmethacrylates / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D008970:Molecular Weight; D009929:Organ Size / Q000187:drug effects; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D011137:Polystyrenes / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D011145:Polyvinyls / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D008298:Maleates; D008299:Maleic Anhydrides; D008768:Methylmethacrylates; D011108:Polymers; D011137:Polystyrenes; D011145:Polyvinyls; C090736:poly(vinyl acetate-maleic anhydride); C025704:Styromal