title: The cytokine-mediated imbalance between coagulant and anticoagulant mechanisms in sepsis and endotoxaemia.
abstract: Disseminated intravascular coagulation (DIC) is a frequently occurring complication of sepsis and may contribute to multiple organ failure. More insight into the pathogenesis of this derangement of the coagulation system is necessary to develop more effective therapeutic strategies for this condition. Recently, more detailed knowledge on the pathogenetic pathways involved in DIC has been obtained by the study of models of experimental bacteraemia and endotoxaemia in human subjects and non-human primates. The mechanisms that lead to activation of coagulation, potentiated by the simultaneous depression of physiological inhibitory systems and to impaired function of the fibrinolytic system, are outlined in this review. In addition, the mediatory role of various cytokines in the derangement of coagulation is discussed.
authors.affiliation: Center for Haemostasis, Thrombosis, Athersclerosis and Inflammation Research, University of Amsterdam, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Levi
authors.forename: T
authors.initials: T
authors.lastname: van der Poll
authors.forename: H
authors.initials: H
authors.lastname: ten Cate
authors.forename: S J
authors.initials: SJ
authors.lastname: van Deventer
mesh_terms: D000925:Anticoagulants / Q000494:pharmacology*; D016470:Bacteremia / Q000378:metabolism; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology*; D016207:Cytokines / Q000502:physiology*; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000378:metabolism; D019446:Endotoxemia / Q000097:blood* / Q000378:metabolism; D005342:Fibrinolysis / Q000502:physiology; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D008297:Male; D018805:Sepsis / Q000097:blood* / Q000378:metabolism
chemical_list: D000925:Anticoagulants; D016207:Cytokines