Asystole during dipyridamole infusion in patients without coronary artery disease or beta-blocker therapy.
The authors report two patients without coronary artery disease who experienced asystole during the IV infusion of dipyridamole on routine TI-201 myocardial perfusion imaging and review the literature for possible explanations of this rare side effect. Until now, this side effect was only reported in patients with coronary artery disease or beta-blocker therapy. Yet, the cases lacked both concomitant factors and autonomic dysregulation is suggested as a cause for asystole.
Frossard
M
M
Department of Emergency Medicine, University of Vienna, Austria.
Weiss
K
K
Gössinger
H
H
Zeiner
A
A
Leitha
T
T
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000787:Angina Pectoris / Q000175:diagnosis; D001342:Autonomic Nervous System Diseases / Q000150:complications; D001919:Bradycardia / Q000139:chemically induced; D003326:Coronary Circulation; D003327:Coronary Disease / Q000150:complications; D004176:Dipyridamole / Q000008:administration & dosage / Q000009:adverse effects*; D004562:Electrocardiography / Q000187:drug effects; D005080:Exercise Test; D005500:Follow-Up Studies; D006321:Heart / Q000000981:diagnostic imaging; D006323:Heart Arrest / Q000139:chemically induced*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013794:Thallium Radioisotopes; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000009:adverse effects*
D000319:Adrenergic beta-Antagonists; D019275:Radiopharmaceuticals; D013794:Thallium Radioisotopes; D014665:Vasodilator Agents; D004176:Dipyridamole