title: Effect of azadirachtin A on the fine structure of the midgut of Rhodnius prolixus.
abstract: Rhodnius prolixus fed with azadirachtin A showed significant changes in the ultrastructural organization of the epithelial cells of the stomach and the intestine. Changes included (a) clustering of the microvilli, (b) disorganization of the extracellular membrane layers, (c) modifications in the array of spherocytes, and (d) disorganization of the basal portion of the epithelial cells. We suggest that these changes interfere significantly with the intestinal environment, making it unsuitable for survival and multiplication of the protozoan Trypanosoma cruzi.
authors.affiliation: Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense, Av. Alberto Lamego 2000, Rio de Janeiro, CEP 28015-620, Campos dos Goytacazes, Brasil.
authors.forename: N F
authors.initials: NF
authors.lastname: Nogueira
authors.forename: M
authors.initials: M
authors.lastname: Gonzales
authors.forename: E M
authors.initials: EM
authors.lastname: Garcia
authors.forename: W
authors.initials: W
authors.lastname: de Souza
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000633:toxicity*; D003594:Cytoplasmic Granules / Q000187:drug effects / Q000648:ultrastructure; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D007422:Intestines / Q000187:drug effects* / Q000648:ultrastructure; D036701:Limonins; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects / Q000648:ultrastructure; D013270:Stomach / Q000187:drug effects* / Q000648:ultrastructure; D014315:Triterpenes / Q000633:toxicity*
chemical_list: D000962:Antimalarials; D036701:Limonins; D014315:Triterpenes; C010329:azadirachtin