Serum levels of androstenedione, testosterone and dehydroepiandrosterone sulfate in patients with premature ovarian failure to age-matched menstruating controls.
Serum concentrations of androstenedione, testosterone and dehydroepiandrosterone sulfate (DHEAS) were measured in 29 patients with premature ovarian failure (POF) and an identical number of age-matched normal control subjects. The study was aimed at determining possible differences in androgen concentrations of ovarian and adrenal origin in POF patients and age-matched normal menstruating controls. Serum testosterone and DHEAS concentrations in the 2 populations were not significantly different. The serum androstenedione concentration in the POF patient group (3,077.50 +/- 1,122.33 pmol/l) was significantly lower than in age-matched normal control subjects (4,167.70 +/- 1,381.09 pmol/l, p < 0.005), possibly reflecting the loss of ovarian androstenedione secretion and/or a subtle defect in adrenal steroidogenic capacity.
Elias
A N
AN
Department of Medicine, University of California at Irvine, USA.
Pandian
M R
MR
Rojas
F J
FJ
D000328:Adult; D000735:Androstenedione / Q000097:blood*; D003687:Dehydroepiandrosterone / Q000097:blood*; D005260:Female; D006801:Humans; D008598:Menstruation / Q000097:blood; D016649:Primary Ovarian Insufficiency / Q000097:blood*; D012016:Reference Values; D013739:Testosterone / Q000097:blood*
D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone