[The molecular, cellular and systemic mechanisms of the radioprotective action of multivitamin antioxidant complexes].
Exposure to radiation, as well as holding under conditions of limited mobility during 24 h induced decrease of thymus cell number in mice. Usage of water-dispersed forms of beta-carotene with addition of vitamins E and C protected thymus against cellular devastation induced by irradiation and stress, and increased the efficiency of DNA repair in spleen of irradiated mice.
Riabchenko
N I
NI
Ivannik
B P
BP
Khorokhorina
V A
VA
Riabchenko
V I
VI
Sin'kova
R V
RV
Grosheva
I P
IP
Dzikovskaia
L A
LA
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use*; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects / Q000528:radiation effects; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D005720:Gamma Rays; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D012149:Restraint, Physical; D013154:Spleen / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D013315:Stress, Psychological / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D013950:Thymus Gland / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D014810:Vitamin E / Q000627:therapeutic use*; D019207:beta Carotene / Q000627:therapeutic use*
D000975:Antioxidants; D004338:Drug Combinations; D011837:Radiation-Protective Agents; D019207:beta Carotene; D014810:Vitamin E; D004247:DNA; D001205:Ascorbic Acid