title: Plasmid virulence gene expression induced by short-chain fatty acids in Salmonella dublin: identification of rpoS-dependent and rpo-S-independent mechanisms.
abstract: The Salmonella plasmid virulence spvABCD genes are growth phase regulated and require RpoS for maximal expression in stationary phase. We identified a growth phase-independent expression of spv which is mediated by short-chain fatty acids. During this fatty acid-mediated expression of spv, RpoS is required for induction only during exponential phase. In stationary phase, an rpoS-independent mechanism is responsible for expression of spv.
authors.affiliation: Department of Medicine, University Hospital of Zurich, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: El-Gedaily
authors.forename: G
authors.initials: G
authors.lastname: Paesold
authors.forename: C Y
authors.initials: CY
authors.lastname: Chen
authors.forename: D G
authors.initials: DG
authors.lastname: Guiney
authors.forename: M
authors.initials: M
authors.lastname: Krause
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D003470:Culture Media; D005232:Fatty Acids, Volatile / Q000494:pharmacology*; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D005809:Genes, Regulator; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics*; D012475:Salmonella / Q000235:genetics* / Q000254:growth & development / Q000472:pathogenicity*; D012808:Sigma Factor / Q000235:genetics / Q000502:physiology*; D014774:Virulence / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D003470:Culture Media; D005232:Fatty Acids, Volatile; D012808:Sigma Factor; C069567:sigma factor KatF protein, Bacteria