title: Systemic lupus erythematosus. Diagnosis and treatment.
abstract: Systemic lupus erythematosus is a multisystem inflammatory disease characterized by antinuclear antibody production. The diagnosis of this disease is established on the basis of a constellation of clinical and serologic features. Therapy is directed to specific disease manifestations and involves an array of anti-inflammatory and immunosuppressive agents that are administered judiciously to limit toxicity.
authors.affiliation: Division of Rheumatology, Allergy and Clinical Immunology, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Pisetsky
authors.forename: G
authors.initials: G
authors.lastname: Gilkeson
authors.forename: E W
authors.initials: EW
authors.lastname: St Clair
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000974:Antibodies, Antinuclear / Q000096:biosynthesis / Q000097:blood; D001168:Arthritis / Q000188:drug therapy; D018450:Disease Progression; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D008181:Lupus Nephritis / Q000188:drug therapy
chemical_list: D000893:Anti-Inflammatory Agents; D000974:Antibodies, Antinuclear; D007166:Immunosuppressive Agents