An innate view of gamma delta T cells.
Findings made during the past few years demonstrate that gamma delta T cells apparently share with macrophages a propensity to recognize nonpeptidic molecules of the kind most commonly associated with microorganisms and stressed cells. In general, recognition of these antigens by gamma delta T cells involves the antigen receptor but does not require antigen presenting cells to express MHC gene products or to have a functional antigen processing machinery. Other recent advances continue to support the notion that gamma delta T cells can perform specialized functions related to the repair of tissue damage.
Boismenu
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Department of Immunology, The Scripps Research Institute, IMM-8, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. boismenu@scripps.edu
Havran
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D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism*
D016692:Receptors, Antigen, T-Cell, gamma-delta