title: Spectrum of morphologic changes of lymph nodes in HIV infection.
abstract: Cervical lymph nodes biopsies from 31 HIV positive patients (with or without AIDS) were studied by histologic methods and immunohistochemistry (StreptABC staining of paraffin sections) to identify cellular and extracellular matrix components. The results were the following: (1) the biopsies were included in the stages of follicular hyperplasia without fragmentation FH-FF (4 cases); follicular hyperplasia with follicular fragmentation FH + FF (16 cases); follicular involution FI (6 cases) and diffuse pattern DP (5 cases); (2) the most important alteration was the germinal centers disruption due to follicle lysis, which began in the light zone; (3) there was coincidence between intrafollicular hemorrhages and segmental hyaline mycroangiopathy; (4) during the progression of the disease occurred; (a) an increase in the number of mast cells, CD68+ and Mac 387+ macrophages; (b) a diffuse augment of collagen III, elastic fibers, laminin, fibronectin and proteoglycans; (c) maintenance of Factor VIII-related antigens in the vascular endothelial cells, with decrease in the expression of Ulex-Europeus I lectin. Follicular hyperplasia (FH - FF or FH + FF) was the most common histologic pattern recognized in the lymph nodes of patients without AIDS and follicular involution and difuse pattern were seen in those who had AIDS. The results indicate that the lymph node biopsies may provide important information about the evolutive stage of the disease and its prognosis.
authors.affiliation: Departamento de Patologia e Laboratórios, Faculdade de Medicina, Universidade do Estado do Rio de Janeiro, Brasil.
authors.forename: D D
authors.initials: DD
authors.lastname: Paiva
authors.forename: J C
authors.initials: JC
authors.lastname: Morais
authors.forename: J
authors.initials: J
authors.lastname: Pilotto
authors.forename: V
authors.initials: V
authors.lastname: Veloso
authors.forename: F
authors.initials: F
authors.lastname: Duarte
authors.forename: H L
authors.initials: HL
authors.lastname: Lenzi
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000473:pathology; D003713:Dendritic Cells / Q000473:pathology*; D005109:Extracellular Matrix; D015658:HIV Infections / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology*; D008264:Macrophages; D008407:Mast Cells