The effects of triethanolamine myristate, a fatty acid salt, on the bioavailability of riboflavin in dogs.
A study in dogs was performed in which a physiologic approach to delaying gastric emptying was examined. Triethanolamine myristate (a fatty acid salt) was used to delay gastric emptying in hopes of increasing the bioavailability of riboflavin. A bilayer tablet consisting of triethanolamine myristate and riboflavin resulted in an absolute bioavailability of 2-3 times greater than the bioavailability of riboflavin alone. Increases in bioavailability although to a lesser extent, were also seen with the 30 min pretreatment with triethanolamine myristate. The results suggest that it was possible to delay gastric emptying.
Forusz
H
H
University of Cincinnati Medicl Center, USA.
Ritschel
W A
WA
D000818:Animals; D001682:Biological Availability; D004285:Dogs; D004983:Ethanolamines / Q000494:pharmacology*; D005746:Gastric Emptying / Q000187:drug effects*; D007275:Injections, Intravenous; D017319:Photosensitizing Agents / Q000097:blood / Q000493:pharmacokinetics*; D012256:Riboflavin / Q000097:blood / Q000493:pharmacokinetics*
D004983:Ethanolamines; D017319:Photosensitizing Agents; C009546:triethanolamine; D012256:Riboflavin