Oxygen promotes contraction by endothelin-1 in human umbilical artery.
The influence of oxygen on the contractile response to endothelin-1 in the human umbilical artery was investigated in vitro. Segments of human umbilical artery were suspended in organ baths to record the circular motor activity induced by endothelin-1 at a pO2 of 12 kPascal (kPa) or 45 kPa. Endothelin-1 induced a concentration-dependent contraction which was significantly larger at 45 kPa O2 compared with the contractile response at 12 kPa O2.
Bodelsson
G
G
Department of Obstetrics and Gynecology, University Hospital, Malmö, Sweden.
Laursen
M
M
Stjernquist
M
M
D019332:Endothelin-1 / Q000494:pharmacology*; D005260:Female; D006801:Humans; D009119:Muscle Contraction / Q000187:drug effects*; D010100:Oxygen / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D011247:Pregnancy; D014469:Umbilical Arteries / Q000502:physiology*
D019332:Endothelin-1; D011189:Potassium Chloride; D010100:Oxygen