title: Subthreshold stimulation in the region of the slow pathway during atrioventricular node reentrant tachycardia: correlation with effect of radiofrequency catheter ablation.
abstract: OBJECTIVE
  The present study sought to investigate the role of subthreshold stimulation in patients with atrioventricular node reentrant tachycardia (AVNRT) undergoing catheter ablation of the slow pathway.
  
  
  BACKGROUND
  Subthreshold stimulation applied to right atrial sites has been demonstrated to terminate AVNRT but has not been correlated with the effects of radiofrequency current delivery to the area of the slow pathway.
  
  
  METHODS
  Eighteen patients with common AVNRT were prospectively included in the study. Sustained AVNRT was reproducibly inducible in all patients (cycle length 334 +/- 58 ms). Anatomic and electrogram guided mapping of the slow pathway was started posteroseptally and continued to more midseptal sites if required. Subthreshold stimulation (3 s, up to 5 mA) during induced AVNRT was performed at each site eligible for slow pathway ablation until termination of AVNRT or capture was observed. Irrespective of the effect of subthreshold stimulation, radiofrequency current was delivered at each site after exclusion of catheter dislocation.
  
  
  RESULTS
  Termination of AVNRT due to block of the anterograde slow pathway induced by subthreshold stimulation occurred without apparent capture in 15 of 18 patients. This phenomenon was exclusively observed at successful posteroseptal to midseptal ablation sites. Subthreshold stimulation was not successful at any of 30 target sites with ineffective radiofrequency current delivery. Thus, subthreshold stimulation identified successful target sites with 83% sensitivity and 100% specificity. Atrioventricular node reentrant tachycardia was abolished in all patients after a median of two (range one to nine) radiofrequency current applications.
  
  
  CONCLUSIONS
  Subthreshold stimulation delivered to the region of the slow pathway terminates AVNRT with high safety and efficacy. High sensitivity and specificity for prediction of the effect of radiofrequency current application suggest that subthreshold stimulation may become a new tool for identifying target sites for slow pathway ablation.
authors.affiliation: Department of Cardiology, University Hospital Eppendorf, Hamburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Willems
authors.forename: C
authors.initials: C
authors.lastname: Weiss
authors.forename: T
authors.initials: T
authors.lastname: Hofmann
authors.forename: C
authors.initials: C
authors.lastname: Rickers
authors.forename: T
authors.initials: T
authors.lastname: Meinertz
mesh_terms: D000328:Adult; D017115:Catheter Ablation; D004599:Electric Stimulation Therapy / Q000379:methods*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000628:therapy*; D016896:Treatment Outcome