[Paraneoplastic superior vena cava thrombosis disclosing an ovarian tumor].
We report the case of a patient who was admitted in hospital for evaluation of a superior vena cava thrombosis. The patient exhibited an activated protein C resistance due to an arginine-506 mutation in factor V. Thoracic CT-scan showed a non-compressive complete superior vena cava thrombosis. Other investigations revealed a pleural effusion associated with an ovarian tumor. Pathological data of pleural biopsies showed a papillar carcinoma. Ovarian neoplasia revealed by a paraneoplasic syndrome was diagnosed. Treatment associated cyclophosphamide and carboplatin with anti-K-vitamin was administrated, with a complete remission and disappearance of superior vena cava thrombosis at 27 months of evolution. At this date, we observed a local pelvis recurrence which was treated with paclitaxel associated with surgery.
Padovani
M
M
Département de Pneumologie et Immuno-allergologie, Hôpital Albert-Calmette, Lille.
Tillie-Leblond
I
I
Vennin
P
P
Demarcq
G
G
Wallaert
B
B
D000925:Anticoagulants / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D002291:Carcinoma, Papillary / Q000150:complications* / Q000188:drug therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D005165:Factor V / Q000235:genetics; D005260:Female; D006801:Humans; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D010051:Ovarian Neoplasms / Q000150:complications* / Q000188:drug therapy; D010257:Paraneoplastic Syndromes / Q000188:drug therapy / Q000209:etiology*; D010996:Pleural Effusion / Q000209:etiology; D011486:Protein C / Q000235:genetics; D020151:Protein C Deficiency; D012074:Remission Induction; D013479:Superior Vena Cava Syndrome / Q000188:drug therapy / Q000209:etiology*; D014812:Vitamin K / Q000037:antagonists & inhibitors
D000925:Anticoagulants; D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D011486:Protein C; C095381:factor V Leiden; D014812:Vitamin K; D003520:Cyclophosphamide; D005165:Factor V; D016190:Carboplatin