title: TRF1, a mammalian telomeric protein.
abstract: Telomerase adds TTAGGG repeats onto mammalian chromosome ends, replenishing the terminal sequence loss incurred during DNA replication. This maintenance of telomeric DNA preserves binding sites for telomeric proteins, which form a protective nucleoprotein complex at chromosome ends. The recent isolation of TRF1, the mammalian telomeric-repeat binding factor, should now allow the structure and function of the telomeric complex to be examined in detail.
authors.affiliation: Rockefeller University, New York, NY 10021, USA.
authors.forename: S
authors.initials: S
authors.lastname: Smith
authors.forename: T
authors.initials: T
authors.lastname: de Lange
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D016147:Genes, Tumor Suppressor; D006801:Humans; D008969:Molecular Sequence Data; D020626:Oncogene Proteins v-myb; D011487:Protein Conformation; D012091:Repetitive Sequences, Nucleic Acid; D015682:Retroviridae Proteins, Oncogenic / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D016615:Telomere / Q000737:chemistry / Q000378:metabolism; D035321:Telomeric Repeat Binding Protein 1; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D020626:Oncogene Proteins v-myb; D015682:Retroviridae Proteins, Oncogenic; D035321:Telomeric Repeat Binding Protein 1; D014157:Transcription Factors