[Gingival hypertrophy due to cyclosporine. A review of the literature].
Cyclosporine is now the elective drug for immunosuppressive treatment in organ transplant patients. Compared to traditional immunosuppressants this molecule offers the therapeutic advantage that it does not act indiscriminately on all components of the immune system. In addition to the primary pharmacological action, cyclosporine also presents a number of undesirable effects, among which it is worth mentioning short and long-term nephrotoxicity and the development of neoplasia, in particular lymphomas. Other undesired effects of the drug are the possibility of overinfection, thrombosis, hypertension, hypertrichosis, hepatotoxicity and the development of the hypertrophic and hyperplastic gingival pathology.
Vescovi
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Istituto di Clinica Odontoiatrica, Università degli Studi, Parma.
Savi
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Oppici
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Gennari
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PU
D003094:Collagen / Q000187:drug effects / Q000378:metabolism; D016572:Cyclosporine / Q000009:adverse effects*; D005881:Gingiva / Q000187:drug effects / Q000378:metabolism; D005886:Gingival Hypertrophy / Q000139:chemically induced* / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003094:Collagen