title: Genes expressed in neurons of adult male Drosophila.
abstract: We have identified two genes, roX1 and roX2, whose expression in the adult fly is restricted to neurons of males. The two genes reside on the X chromosome, and each encodes an RNA with no apparent open reading frame. Both genes are physically linked to female-specific genes that encode proteins expressed in the ovary: opt1, a novel peptide transporter, and nod, a member of the kinesin family. The male-specific transcripts are positively regulated by the dosage compensation pathway in an all-or-none fashion. Our data suggest that the multimeric complex of dosage compensation proteins may operate in different ways on different sets of X-linked genes.
authors.affiliation: Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
authors.forename: H
authors.initials: H
authors.lastname: Amrein
authors.forename: R
authors.initials: R
authors.lastname: Axel
mesh_terms: D000367:Age Factors; D000818:Animals; D001921:Brain / Q000166:cytology; D018076:DNA, Complementary / Q000032:analysis; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D017952:Ganglia, Invertebrate / Q000166:cytology; D018628:Gene Dosage; D015870:Gene Expression / Q000502:physiology; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D015723:Gene Library; D017344:Genes, Insect / Q000502:physiology*; D008040:Genetic Linkage; D007301:Insect Hormones / Q000235:genetics; D008297:Male; D008969:Molecular Sequence Data; D009474:Neurons / Q000502:physiology*; D009687:Nuclear Proteins / Q000235:genetics; D017933:Peripheral Nervous System / Q000166:cytology; D012333:RNA, Messenger / Q000032:analysis / Q000502:physiology; D016601:RNA-Binding Proteins / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D012732:Sex Determination Analysis; D014158:Transcription, Genetic / Q000502:physiology; D014960:X Chromosome; D014998:Y Chromosome
chemical_list: D018076:DNA, Complementary; D029721:Drosophila Proteins; D007301:Insect Hormones; D009687:Nuclear Proteins; C092595:Pabp2 protein, Drosophila; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; C097162:Tra protein, Drosophila