title: Salvage treatment for inoperable neck nodes in head and neck cancer using combined iridium-192 brachytherapy and surgical reconstruction.
abstract: The results of debulking surgery and re-irradiation with radioactive implants (brachytherapy) are reported for 39 patients with inoperable metastatic neck nodes from primary head and neck cancers. For 13 patients conventional salvage by partial debulking surgery and brachytherapy proved effective, with 68 per cent control at 1 year, but six patients suffered severe radiation fibrosis, necrosis and contractures. Some 26 patients were treated by combined tumour debulking, skin resurfacing and brachytherapy implant. Initial tumour control and freedom from serious toxicity was achieved in 24 patients. Local control was achieved in 63 per cent of patients at 1 year, with a serious morbidity rate of 12 per cent.
authors.affiliation: Head and Neck Unit, Royal Marsden Hospital, London, UK.
authors.forename: P G
authors.initials: PG
authors.lastname: Cornes
authors.forename: H J
authors.initials: HJ
authors.lastname: Cox
authors.forename: P R
authors.initials: PR
authors.lastname: Rhys-Evans
authors.forename: N M
authors.initials: NM
authors.lastname: Breach
authors.forename: J M
authors.initials: JM
authors.lastname: Henk
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D003131:Combined Modality Therapy; D006258:Head and Neck Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D007496:Iridium Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D016879:Salvage Therapy / Q000379:methods; D013518:Surgery, Plastic; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D007496:Iridium Radioisotopes