Serotonin 5-HT3 receptor binding kinetics in the cortex of suicide victims are normal.
Serotonergic abnormalities have been identified in the brain of suicide victims independent of psychiatric diagnosis. We report the first study of serotonin 5-HT3 receptors in the brain of suicide victims. There were no differences in the number (Bmax) or affinity (KD) of 5-HT3 receptors in the temporal cortex of suicide victims compared to matched controls. There was a negative correlation between brain serotonin levels and receptor number (r = -0.5, p = 0.04) in both groups. This study indicates that alterations in serotonergic function in the brain of suicide victims do not appear to directly involve the 5-HT3 receptor.
Mann
J J
JJ
Department of NEuroscience, New York State Psychiatric Institute, New York, USA.
Arango
V
V
Henteleff
R A
RA
Lagattuta
T F
TF
Wong
D T
DT
D000328:Adult; D001923:Brain Chemistry / Q000502:physiology; D002540:Cerebral Cortex / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007191:Indazoles; D007700:Kinetics; D008297:Male; D011985:Receptors, Serotonin / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists; D013405:Suicide; D014326:Tropanes; D014364:Tryptophan / Q000378:metabolism
D007191:Indazoles; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D014326:Tropanes; C061531:LY 278584; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan