Human lymphocyte micronucleus genotoxicity test with mixtures of phytochemicals in environmental concentrations.
This study was carried out to assess the genotoxicity of mixtures of pesticides using the micronucleus test with human lymphocytes in culture. Benomyl, azinphos-methyl, diazinon, dimethoate, pirimiphos-methyl pesticides were tested at doses estimated from their daily intake (EDI). Benomyl is a carbamate fungicide, the other compounds are organophosphorous insecticides. The compounds were tested both separately and in combination. The results showed a weak genotoxicity for three of the four organophosphorous insecticides and for benomyl. The various mixtures did not give additive effects.
Bianchi-Santamaria
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Institute of Medical Pharmacology, University of Pavia, Italy.
Gobbi
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Cembran
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Arnaboldi
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A
D001387:Azinphosmethyl / Q000633:toxicity; D001542:Benomyl / Q000633:toxicity; D002478:Cells, Cultured; D003976:Diazinon / Q000633:toxicity; D004117:Dimethoate / Q000633:toxicity; D004347:Drug Interactions; D004785:Environmental Pollutants / Q000633:toxicity*; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D015162:Micronucleus Tests; D009946:Organothiophosphorus Compounds / Q000633:toxicity; D010575:Pesticides / Q000633:toxicity*
D004785:Environmental Pollutants; D009946:Organothiophosphorus Compounds; D010575:Pesticides; D001387:Azinphosmethyl; C014153:pirimiphos methyl; D001542:Benomyl; D004117:Dimethoate; D003976:Diazinon