title: The single and multiple dose pharmacokinetics of pranlukast in healthy volunteers.
abstract: OBJECTIVE
  The pharmacokinetics of pranlukast, a leukotriene LTD4 antagonist, were studied in 48 young, healthy subjects after single and repeated oral doses (given every 12 h) ranging from 112.5 to 675 mg. The doses were administered 30 minutes after a light breakfast.
  
  
  RESULTS
  Maximal drug concentrations generally occurred between 2 and 6 h after dosing, and there was some evidence of an absorption lag-time. Secondary peaks were observed in the plasma concentration vs. time profiles of many of the study subjects after both single and repeated doses, particularly during the period of maximum drug absorption. In general, after both single and repeated doses, there were related increases in the corresponding Cmax and AUC with a rise in dose, although the increase was diminished at doses above 450 mg. With repeated dosing of pranlukast the mean AUC was generally higher (up to 1.6-fold), and the higher plasma concentrations allowed characterisation of a longer mean t 1/2 than after single dose administration. The mean steady-state trough plasma concentrations attained after evening doses were considerably higher (up to 14-fold) than those obtained after the morning dose.
  
  
  CONCLUSIONS
  The data suggested that the pharmacokinetics of pranlukast are influenced by the time of dosing. Based on analysis of urinary 6 beta-hydroxycortisol excretion, there was no evidence that pranlukast modified the metabolic activity of cytochrome P-450 3A isoenzymes.
authors.affiliation: College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada.
authors.forename: D R
authors.initials: DR
authors.lastname: Brocks
authors.forename: J W
authors.initials: JW
authors.lastname: Upward
authors.forename: P
authors.initials: P
authors.lastname: Georgiou
authors.forename: G
authors.initials: G
authors.lastname: Stelman
authors.forename: E
authors.initials: E
authors.lastname: Doyle
authors.forename: E
authors.initials: E
authors.lastname: Allen
authors.forename: P
authors.initials: P
authors.lastname: Wyld
authors.forename: M J
authors.initials: MJ
authors.lastname: Dennis
mesh_terms: D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy; D002867:Chromones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D017998:Leukotriene D4 / Q000037:antagonists & inhibitors*; D008875:Middle Aged
chemical_list: D002867:Chromones; D017998:Leukotriene D4; D003577:Cytochrome P-450 Enzyme System; C047681:pranlukast