Evidence for the embryonic origin of partial chromosome 7 deletion in monozygotic twins with juvenile chronic myelogenous leukemia.
During donor evaluation for allogeneic bone marrow transplantation (BMT) of a 28-month-old child with juvenile chronic myelogeneous leukemia (JCML) with 46,XY,-7,+mar karyotype, the potential donor twin brother was found to be thrombocytopenic. Subsequent genotype analysis determined monozygosity with 98% probability. Bone marrow analysis of the twin brother revealed the same 46,XY,-7,+mar karyotype and a diagnosis of JCML was made. Metaphase FISH studies documented that mar chromosome in both twins contains the pericentromeric region of chromosome 7 and thus both twins had a partial monosomy of chromosome 7. A possible embryonic origin of del(7) is proposed.
Najfeld
V
V
Tumor Cytogenetics Laboratory, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029-6574, USA.
Vlachos
A
A
Parker
R
R
Burnett
W
W
Scalise
A
A
Fruchtman
S
S
D000970:Antineoplastic Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics / Q000648:ultrastructure*; D003131:Combined Modality Therapy; D004200:Diseases in Twins / Q000196:embryology* / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D016898:Interferon-alpha / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000196:embryology* / Q000235:genetics / Q000628:therapy; D008297:Male; D014430:Twins, Monozygotic / Q000235:genetics*
D000970:Antineoplastic Agents; D016898:Interferon-alpha