Lack of association of the angiotensin converting enzyme polymorphism with essential hypertension in a Chinese population.
To examine the association between insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE) gene and essential hypertension in a Chinese population, a case-control study was conducted using 157 hypertensive and 115 normotensive subjects. The I/D polymorphism of the ACE gene was identified by polymerase chain reaction. Plasma ACE activity was determined using spectrophotometry. The difference of allele frequencies between normotensives and hypertensives was statistically significant (chi 2 = 4.467, P = .035), while the genotype distribution was not different between normotensive and hypertensive subjects (chi 2 = 3.954, P = .138). Plasma ACE activity was highest in the DD genotype, followed by the ID genotype, and the lowest in the II genotype (P = .0001 in normotensives and P = .163 in hypertensives, respectively). Thus, we conclude that the ACE gene polymorphism is not associated with essential hypertension in this Chinese population, but plasma ACE activity is genetically determined in the normotensive Chinese.
Chiang
F T
FT
Department of Laboratory Medicine, National Taiwan University, Taipei, Republic of China.
Lai
Z P
ZP
Chern
T H
TH
Tseng
C D
CD
Hsu
K L
KL
Lo
H M
HM
Tseng
Y Z
YZ
D000328:Adult; D000368:Aged; D002681:China; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D008875:Middle Aged; D015999:Multivariate Analysis; D007703:Peptidyl-Dipeptidase A / Q000032:analysis / Q000097:blood / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic
D007703:Peptidyl-Dipeptidase A