title: Epidemiology of Whipple's disease in Germany. Analysis of 110 patients diagnosed in 1965-95.
abstract: BACKGROUND
  The epidemiology of Whipple's disease (WD) is obscure. To obtain basic data, we performed an evaluation of WD patients in Germany.
  
  
  METHODS
  Information was collected from 110 WD patients diagnosed during 1965-95 at 5 institutions in different regions of Germany. Four items were evaluated: 1) year in which the diagnosis was made; 2) residence and 3) age at the time of diagnosis; and 4) sex.
  
  
  RESULTS
  WD patients originated from all parts of Germany. The incidence of new cases was relatively stable, with a mean of one to two cases per year per collecting centre. In 1995, a maximum of 13 new WD patients was diagnosed. There was a significant increase in the mean age of patients (1965-75, 48.7 years; confidence interval, +/- 3.98 years; 1976-85, 50.7 years, +/- 3.69 years; 1986-95, 57.0 years, +/- 2.80 years; P < 0.01) and an increasing proportion of women (1965-85, 4%; 1986-1995, 22%).
  
  
  CONCLUSIONS
  Whipple's disease is not quite as rare as commonly assumed. There is no obvious geographic predominance. During the past three decades, the demography of WD patients has changed.
authors.affiliation: Institute of Pathology, University of Heidelberg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: von Herbay
authors.forename: H F
authors.initials: HF
authors.lastname: Otto
authors.forename: M
authors.initials: M
authors.lastname: Stolte
authors.forename: F
authors.initials: F
authors.lastname: Borchard
authors.forename: T
authors.initials: T
authors.lastname: Kirchner
authors.forename: H J
authors.initials: HJ
authors.lastname: Ditton
authors.forename: M
authors.initials: M
authors.lastname: Maiwald
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000704:Analysis of Variance; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D017678:Sex Distribution; D008061:Whipple Disease / Q000453:epidemiology*