Comparative effects of thiopentone and propofol on respiratory resistance after tracheal intubation.
To compare the effects of propofol and thiopentone on tracheal intubation-induced bronchoconstriction, 37 patients were allocated randomly to anaesthesia with either thiopentone 4 mg kg-1 followed by a 15-mg kg-1 h-1 continuous infusion or propofol 3 mg kg-1 followed by a 9-mg kg-1 h-1 continuous infusion. Intubation was facilitated by vecuronium 0.1-0.2 mg kg-1. Respiratory system resistance (Rrs) was measured by a CP-100 pulmonary function monitor, 5 min after intubation. The 5-min post-intubation Rrs values were significantly lower in the propofol group (8.5 (SD 1.5) cm H2O litre-1 S-1) than in the thiopentone group (10.9 (3.2) cm H2O litre-1 S-1). Thirty minutes after commencing isoflurane-nitrous oxide anaesthesia, Rrs declined by 17.5 (SEM 3.6)% from baseline in the thiopentone group, but by only 1.6 (2.6)% in the propofol group. We conclude that the dose of propofol administered provided more protection against tracheal intubation-induced bronchoconstriction than an induction dose of thiopentone.
Wu
R S
RS
Department of Anaesthesiology, Chang Gung Memorial Hospital, Taiwan, Republic of China.
Wu
K C
KC
Sum
D C
DC
Bishop
M J
MJ
D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D018685:Anesthetics, Inhalation / Q000494:pharmacology; D018686:Anesthetics, Intravenous / Q000627:therapeutic use*; D001986:Bronchial Spasm / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009093:Mucus / Q000378:metabolism; D015742:Propofol / Q000627:therapeutic use*; D013874:Thiopental / Q000627:therapeutic use*; D014132:Trachea / Q000378:metabolism
D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D013874:Thiopental; D015742:Propofol