[Coronary risk factors in chronic hemodialysis patients].
BACKGROUND
In contrast to persons with normal renal function, coronary risk factors or indicators until yet could not clearly be defined in renal insufficiency.


METHODS
30 patients under chronic hemodialysis therapy were investigated; 15 patients with severe coronary artery disease and 15 patients with normal coronary angiogram were compared. Numerous factors of the manner of living (diet, smoking behaviour etc.) were registered and glucose and lipid metabolism, hemostatic and fibrinolytic system as well as blood pressure level were investigated.


RESULTS
Besides higher HDL-cholesterol and tissue plasminogen activator (TPA) levels in patients without coronary heart disease, no significant difference could be found between both groups. The higher HDL levels were mainly due to the higher percentage of women in the coronary healthy group. There was no evidence of insulin resistance as a major pathogenic factor in the group with coronary heart disease. The blood pressure levels were not significantly different in both groups.


CONCLUSIONS
Our quantitative examination of accepted or suspected coronary risk factors revealed no entity which turned out to be a reliable risk indicator for practical purposes.
Lübbecke
F
F
Zentrum für Innere Medizin, Medizinische Klinik II, Justus-Liebig-Universität Giessen.
Matthias
F R
FR
Richter
U
U
Frettlöh
A
A
Katz
N
N
Wizemann
V
V
Schütterle
G
G
D000368:Aged; D001779:Blood Coagulation Factors / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure / Q000502:physiology; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood*; D008019:Life Style; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012307:Risk Factors
D001779:Blood Coagulation Factors; D001786:Blood Glucose; D007328:Insulin; D008055:Lipids