title: The role of water in protein-DNA interactions.
abstract: It is becoming well accepted that water plays an important role in both the specificity and affinity of protein-DNA interactions. Recently, a combination of structural, biochemical and thermodynamic techniques has particularly enhanced our understanding of the role of water in complexes between DNA and three different proteins: the trp repressor; the homeodomain; and the glucocorticoid receptor DNA-binding domain.
authors.affiliation: Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. jws@sbl.salk.edu
authors.forename: J W
authors.initials: JW
authors.lastname: Schwabe
mesh_terms: D004247:DNA / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism; D013816:Thermodynamics; D014867:Water / Q000737:chemistry*
chemical_list: D004268:DNA-Binding Proteins; D014867:Water; D004247:DNA