[Acute interstitial nephritis. Role of ceftazidime].
A 22-year-old man treated with ceftazidime-amikacine for a Pseudomonas aeruginosa pneumonia, experienced two days later allergic symptoms, acute renal failure and urinary sediment abnormalities. The renal biopsy showed an acute interstitial nephritis. Basophils stimulation test was positive for ceftazidime. Early diagnosis and discontinuation of the suspected agent is essential to allow rapid and complete recovery of renal function.
Ladagnous
J F
JF
Service d'anesthésie-réanimation, HIA Legouest, Metz, France.
Rousseau
J M
JM
Gaucher
A
A
Saïssy
J M
JM
Pitti
R
R
D000208:Acute Disease; D000328:Adult; D002442:Ceftazidime / Q000009:adverse effects*; D002511:Cephalosporins / Q000009:adverse effects*; D004802:Eosinophilia / Q000139:chemically induced; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology; D012075:Remission, Spontaneous
D002511:Cephalosporins; D002442:Ceftazidime