Serum interleukin-10 in acquired immunodeficiency syndrome lymphoma patients. Seroco-Hemoco Study Group.
Interleukin-10 (IL-10) has multiple effects on lymphoid development, particularly as a stimulant of activated B-cell proliferation and differentiation. It is thought that IL-10 might play a role in the development of B lymphoid malignancies based on the observation that lymphomatous tissues from HIV+ patients contain numerous cells containing IL-10 mRNA as well as IL-10 protein. The aim of this study using an Elisa test was to analyze IL-10 in the serum of 18 HIV+ patients with non Hodgkin's B lymphoma (NHL) and compared the presence of this cytokine in the serum of 18 HIV+ patients without NHL. In this comparative study we also considered the different parameters such as the mode of contamination, sex, age and number of CD4 cells. 44% of the patients with HIV-related NHL had significant levels of IL-10 (> or = 12 pg/ml) in their serum, in comparison to the patients without NHL who did not show detectable serum IL-10.
Edelman
L
L
Institut Pasteur, Paris, France.
Deveau
C
C
Raphael
M
M
Monchatre
E
E
Gabarre
J
J
Deville-Chabrol
A
A
Pialoux
G
G
Emilie
D
D
Joab
I
I
Galanaud
P
P
D000328:Adult; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016679:Genome, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D016483:Lymphoma, AIDS-Related / Q000097:blood* / Q000821:virology; D016393:Lymphoma, B-Cell / Q000097:blood* / Q000821:virology; D008297:Male; D008875:Middle Aged
D016753:Interleukin-10