title: Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning.
abstract: Cadherins, a family of Ca2+-dependent cell-cell adhesion molecules, mediate neural cell-cell interactions and may play important roles in neural development. By searching for molecules that interact with beta-catenin, a cytoplasmic regulator of cadherins, we have identified a new member of the cadherin family, which we named human cadherin-14. Cadherin-14 had high amino acid sequence homology with the type II subgroup of cadherins and was broadly expressed in the central nervous system. Cadherin-14 is a novel neurally specific cell-cell adhesion molecule and may regulate neural morphogenesis.
authors.affiliation: Pathology Division, National Cancer Center Research Institute, 5-1-1, Tsukiji, Tokyo 104, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shibata
authors.forename: Y
authors.initials: Y
authors.lastname: Shimoyama
authors.forename: M
authors.initials: M
authors.lastname: Gotoh
authors.forename: S
authors.initials: S
authors.lastname: Hirohashi
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D015820:Cadherins / Q000235:genetics* / Q000302:isolation & purification; D003001:Cloning, Molecular; D006801:Humans; D008969:Molecular Sequence Data; D011485:Protein Binding / Q000235:genetics; D011994:Recombinant Proteins / Q000235:genetics / Q000302:isolation & purification; D016415:Sequence Alignment
chemical_list: C104822:CDH18 protein, human; D015820:Cadherins; D011994:Recombinant Proteins