title: [Value of cyclosporine in the treatment of the recurrence of nephrosis after renal transplantation].
abstract: From May 1992 to December 1994, 14 children with end stage renal failure secondary to steroid-resistant idiopathic nephrotic syndrome received a cadaver kidney graft. Immediate recurrence of the nephrotic syndrome occurred in four patients. In the four patients, a complete remission was observed shortly after the start of intravenous cyclosporin; two children received in addition methylprednisolone pulses for secondary rejection. Two children were still protein-free 9 and 15 months after transplantation. In the third patient, proteinuria relapsed after 9 months of complete remission and persisted in spite of the reintroduction of intravenous cyclosporin. The fourth graft was lost at 3.5 month from irreversible rejection. The creatinine clearance of the 3 functioning grafts was respectively: 73, 76 and 92 ml/mn/1.73 m2 16, 10 and 15 months after transplantation. Intravenous cyclosporin started shortly after the recurrence, maintaining blood levels between 200 and 300 ng/ml, may induce a remission in recurrent nephrotic syndrome after renal transplantation in childhood.
authors.affiliation: Service de néphrologie pédiatrique, INSERM U423, Hôpital Necker-Enfants-Malades, Paris.
authors.forename: B
authors.initials: B
authors.lastname: Ranchin
authors.forename: M F
authors.initials: MF
authors.lastname: Gagnadoux
authors.forename: M
authors.initials: M
authors.lastname: Broyer
authors.forename: A
authors.initials: A
authors.lastname: Lehnert
authors.forename: A
authors.initials: A
authors.lastname: Juresco
authors.forename: N
authors.initials: N
authors.lastname: Chérif
authors.forename: D
authors.initials: D
authors.lastname: Jan
authors.forename: D
authors.initials: D
authors.lastname: Droz
authors.forename: M C
authors.initials: MC
authors.lastname: Gubler
authors.forename: P
authors.initials: P
authors.lastname: Niaudet
mesh_terms: D002675:Child, Preschool; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D012008:Recurrence
chemical_list: D016572:Cyclosporine