title: Sertoli Leydig cell tumor with malignant heterologous elements and raised alpha-fetoprotein: a case report.
abstract: A case of a Sertoli Leydig cell tumor in a young female with virilizing symptoms and an androgenic endocrine profile with raised serum alpha-fetoprotein is presented. The tumor consisted predominantly of malignant epithelial and mesenchymal heterologous elements. Such a combination in the same tumor has to the best of our knowledge not been previously reported in English literature. The Leydig cells were immunohistochemically positive for alpha-fetoprotein. Sertoli Leydig cell tumors should be included in the differential diagnosis of tumors with raised alpha-fetoprotein. Chemotherapy in addition to surgery has been recommended for these tumors.
authors.affiliation: Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Z N
authors.initials: ZN
authors.lastname: Singh
authors.forename: M K
authors.initials: MK
authors.lastname: Singh
authors.forename: P
authors.initials: P
authors.lastname: Chopra
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms / Q000097:blood* / Q000473:pathology*; D018310:Sertoli-Leydig Cell Tumor / Q000097:blood* / Q000473:pathology*; D014770:Virilism; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D000509:alpha-Fetoproteins