[The ethanol elimination pharmacokinetics--the effects of genotypes of ALDH2 and CYP2E1 on the ethanol metabolism].
The effects of the genotypes of CYP2E1, ALDH2, ADH upon the blood ethanol and acetaldehyde levels were investigated. The predicting 95% confidence bounds determined on regression analysis of the data suggested that after venous injection of ethanol, the blood ethanol and acetaldehyde concentrations in a volunteer normal homozygous for ALDH2 (ALDH2*1/1) were significantly lower than that heterozygous (ALDH2*1/2). And the blood ethanol and acetaldehyde concentrations in a volunteer with C2 allele (C1/C2) were significantly lower than that in (C1/1). However, there were no significant differences in the blood ethanol and acetaldehyde concentrations between volunteers with ADH2*1/1 and ALDH2*1/2. It is possible that the ALDH2*1 and C2 alleles may correspond to the lower blood ethanol and acetaldehyde concentrations after intravenous administrations of 0.2 g /kg of ethanol.
Iwahashi
K
K
Department of Neuropsychiatry, Faculty of Medicine, Kagawa Medical University, Japan.
Ameno
K
K
Kinoshita
H
H
Nakamura
K
K
Miyatake
R
R
Suwaki
H
H
Ijiri
I
I
Ishikawa
Y
Y
Ichikawa
Y
Y
Mendori
T
T
Orino
K
K
D000328:Adult; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D000431:Ethanol / Q000493:pharmacokinetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans
D000431:Ethanol; D019392:Cytochrome P-450 CYP2E1; D000444:Aldehyde Dehydrogenase