Improved distribution of pulmonary flush solution to the tracheobronchial wall in pulmonary transplantation.
This report describes the experimental results obtained with conventional (pulmonary artery, PA) flushing versus retrograde perfusion (via left atrium, LA) using 99mTc-labeled macroaggregated albumin (MAA-99mTc) to ascertain the distribution throughout the tracheobronchial (TB) tree in 10 Large-White pigs. Lung preservation was achieved with 4 degrees C Euro-Collins solution (60 ml/kg) instilled via PA (n = 5) or LA (n = 5). Simultaneously, MAA-99mTc was given using the same respective route and the isotope uptake quantified at different TB levels after heart-lung block harvest and dissection of all tissue adjacent to TB: proximal and distal trachea and right and left main bronchi. Retrograde distribution resulted in a significantly higher 99mTc count compared to the PA route (p < 0.01).
Varela
A
A
Thoracic and Cardiovascular Surgery, Hospital Pureta de Hierro, Madrid, Spain.
Montero
C G
CG
Córdoba
M
M
Antequera
A
A
Pérez
M
M
Tabuenca
M J
MJ
Ortiz Berrocal
J
J
Tendillo
F J
FJ
Mascias
A
A
Santos
M
M
Castillo Olivares
J L
JL
D000818:Animals; D001980:Bronchi / Q000000981:diagnostic imaging / Q000378:metabolism*; D006325:Heart Atria; D006982:Hypertonic Solutions / Q000378:metabolism*; D007261:Infusions, Intra-Arterial; D008168:Lung / Q000502:physiology*; D016040:Lung Transplantation; D009926:Organ Preservation / Q000379:methods*; D019188:Organ Preservation Solutions / Q000378:metabolism*; D010477:Perfusion / Q000379:methods; D011651:Pulmonary Artery; D011877:Radionuclide Imaging; D013552:Swine; D013668:Technetium Tc 99m Aggregated Albumin; D014132:Trachea / Q000000981:diagnostic imaging / Q000378:metabolism*
C037096:Euro-Collins' solution; D006982:Hypertonic Solutions; D019188:Organ Preservation Solutions; D013668:Technetium Tc 99m Aggregated Albumin