Mutation induction by high-density, 50-Hz magnetic fields in human MeWo cells exposed in the DNA synthesis phase.
Exposure of cultured human MeWo cells to high-density (400 mT at 50 Hz) extremely low frequency magnetic fields (ELF-MF) induced mutations in the hypoxanthine-guanine phosphoribosyl transferase gene. Mutation induced by the ELF-MF increased during the DNA-synthesis phase in synchronously growing cells. DNA replication errors and/or disturbance of the mismatch repair systems caused by exposure to ELF-MF may be involved in the mutagenic effect.
Miyakoshi
J
J
Department of Radiation Genetics, Faculty of Medicine, Kyoto University, Japan.
Kitagawa
K
K
Takebe
H
H
D004247:DNA / Q000096:biosynthesis*; D004574:Electromagnetic Fields / Q000009:adverse effects*; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics*; D009154:Mutation; D016196:S Phase / Q000235:genetics; D014407:Tumor Cells, Cultured
D004247:DNA; D007041:Hypoxanthine Phosphoribosyltransferase