Myocardial infarction postpartum in patients taking bromocriptine for the prevention of breast engorgement.
Three cases of myocardial infarction (MI) in women taking bromocriptine for milk suppression are presented. The incidents occurred in 1993 and 1994, the last only two weeks before the withdrawal of the drug from the American market as a drug suitable for ablactation. In one patient, the MI presented on the 12 day postpartum and was accompanied by signs and symptoms reminiscent to ergotism. Another mother suffered MI, accompanied by hypertension, six days after a vaginal delivery complicated by postpartum haemorrhage. The third patient began to take bromocriptine more than 2 weeks postpartum and died suddenly 24 days after her childbirth. To the knowledge of the authors, these are the 12th to 14th literary reports describing an apparent association between the use of bromocriptine for ablactation and the occurrence of MI in the puerperium.
Hopp
L
L
Department of Pediatrics, UMDNJ-New Jersey Medical School, Newark, USA.
Haider
B
B
Iffy
L
L
D000328:Adult; D001971:Bromocriptine / Q000009:adverse effects*; D004562:Electrocardiography; D005260:Female; D006727:Hormone Antagonists / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D008895:Milk, Human / Q000187:drug effects*; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000453:epidemiology / Q000503:physiopathology; D049590:Postpartum Period / Q000187:drug effects* / Q000502:physiology
D006727:Hormone Antagonists; D001971:Bromocriptine