Retinoblastoma protein in growth suppression and death protection.
Puzzling new information indicates an inadequacy in our understanding of the retinoblastoma protein (RB). RB and the transcription factor E2F appear to be collaborators. RB-E2F interaction is necessary but not sufficient for growth suppression. Unbecoming of a tumor suppressor, RB has an active role in antagonizing the death response. How RB integrates its multiple functions into a tumor suppression program is still an open issue.
Wang
J Y
JY
Department of Biology, University of California, San Diego 9500 Gilman Drive, La Jolla, California 92093-0347, USA. jywang@ucsd.edu
D000818:Animals; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D016923:Cell Death / Q000502:physiology*; D002455:Cell Division / Q000502:physiology*; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D006801:Humans; D016160:Retinoblastoma Protein / Q000502:physiology*; D056465:Retinoblastoma-Binding Protein 1; D050680:Transcription Factor DP1; D014157:Transcription Factors / Q000378:metabolism
D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D016160:Retinoblastoma Protein; D056465:Retinoblastoma-Binding Protein 1; D050680:Transcription Factor DP1; D014157:Transcription Factors