title: Detrusor myopathy: an accurate predictor of bladder hypocompliance and contracture in interstitial cystitis.
abstract: OBJECTIVE
  To determine whether any histological characteristics within the detrusor in cases of early interstitial cystitis (IC) predict the subsequent development of severe symptoms due to bladder contracture.
  
  
  METHODS
  The detrusor muscle component of bladder biopsies from 21 patients with IC was examined in sections stained with haematoxylin and eosin. Videocystometrography was performed at least 2 months after the biopsy and the patients were then followed up clinically for at least 3 years.
  
  
  RESULTS
  The detrusor appeared normal in 13 patients; in eight there was evidence of detrusor myopathy. Patients with biopsies confirming detrusor myopathy were significantly more likely to have hypocompliant bladders than those with normal detrusor muscle histology (P < 0.02). Over the following 3 years, six of the eight patients with detrusor myopathy developed progressively severe symptoms and required subtotal cystectomy and enterocystoplasty. None of the 13 patients without detrusor myopathy required bladder substitution.
  
  
  CONCLUSIONS
  In IC, detrusor myopathy is associated with bladder hypocompliance. Patients with detrusor myopathy appear to have more severe disease and are more likely to progress to bladder contracture requiring substitution enterocystoplasty.
authors.affiliation: Department of Urology, Chelsea and Westminster Hospital, London.
authors.forename: T J
authors.initials: TJ
authors.lastname: Christmas
authors.forename: G L
authors.initials: GL
authors.lastname: Smith
authors.forename: J
authors.initials: J
authors.lastname: Rode
mesh_terms: D003286:Contracture / Q000473:pathology / Q000503:physiopathology; D018856:Cystitis, Interstitial / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009135:Muscular Diseases / Q000473:pathology* / Q000503:physiopathology; D011312:Pressure; D012680:Sensitivity and Specificity; D014554:Urination; D014563:Urodynamics