title: A novel method to evaluate thromboresistance of drip chambers with filter used in extracorporeal blood circuits for hemodialysis.
abstract: We have developed a novel method to simultaneously evaluate thromboresistance of two different types of drip chambers with a filter used in extracorporeal blood circuits for hemodialysis using canine arteriovenous shunt models. Bilateral bypasses between the femoral artery and vein on both sides of the animal were formed with 2 test circuits consisting of polyvinyl chloride tubing and two types of drip chambers with filters. Blood flow was derived into the drip chambers with a filter and returned to the femoral vein without using peristaltic pumps and systemic anticoagulants. By monitoring the quantitative changes of the blood flow rate through each drip chamber with a filter and measuring the time elapsed before the blood flow through its was completely obstructed by clots, thromboresistance of the drip chambers was evaluated under the same blood conditions. The drip chamber with a filter that had a small effective filter area, a big pore size, and slitlike pores showed better thromboresistance. This novel method proved useful in evaluating the thromboresistance of differently designed drip chambers with a filter.
authors.affiliation: Department of Membranes and Biomedical Materials, Japan Research Center, W.R. Grace & Co.-Conn., Atsugi, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamazaki
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Mori
authors.forename: T
authors.initials: T
authors.lastname: Satoh
authors.forename: S
authors.initials: S
authors.lastname: Kubota
mesh_terms: D000818:Animals; D001166:Arteriovenous Shunt, Surgical; D001672:Biocompatible Materials; D001783:Blood Flow Velocity; D004285:Dogs; D005112:Extracorporeal Circulation / Q000592:standards*; D005374:Filtration / Q000295:instrumentation; D008297:Male; D011143:Polyvinyl Chloride / Q000378:metabolism; D006435:Renal Dialysis / Q000592:standards*; D012212:Rheology; D013927:Thrombosis / Q000517:prevention & control
chemical_list: D001672:Biocompatible Materials; D011143:Polyvinyl Chloride