[Effects of a synthetic carbon-mineral sorbent and antibiotics on the development of combined radiation and thermal injury].
Male Wistar rats exposed to whole-body irradiation, the midline absorbed dose was 7.5 Gy. Full-sickness thermal burn 15% of body surface inflicted immediately after irradiation. Experimental study of the therapeutic efficacy of enterosorption alone or in combination with antibiotics doxycycline and ciprofloxacin performed. The strong decrease of bacterial endotoxemia, toxic oligopeptides' level and general blood toxicity revealed after treatment compared with non-treated animals with combined injuries. Corrections of postirradiation intestinal dysbacteriosis revealed too. The best result observed when carbon mineral sorbent and antibiotics administered daily within the first 10-14 days after combined injury. Survival of treated animals increased up to 80% (all rats of control group died during 30 days after combined injury).
Nesterenko
V S
VS
Makarov
G F
GF
Budagov
R S
RS
Bollueva
N G
NG
Iatsenko
E M
EM
Rachkovskaia
L N
LN
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001419:Bacteria / Q000302:isolation & purification; D002056:Burns / Q000150:complications / Q000628:therapy*; D002244:Carbon; D002939:Ciprofloxacin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004318:Doxycycline / Q000627:therapeutic use*; D016061:Enterosorption / Q000379:methods; D007422:Intestines / Q000382:microbiology; D008297:Male; D008903:Minerals; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000150:complications / Q000628:therapy*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014916:Whole-Body Irradiation
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D008903:Minerals; D002939:Ciprofloxacin; D002244:Carbon; D004318:Doxycycline