Influence of cisapride on the pharmacokinetics and antihypertensive effect of sustained-release nifedipine.
To investigate the clinical significance of interactions between cisapride and sustained-release nifedipine, we compared the plasma nifedipine concentration and blood pressure after administration of nifedipine alone (20 mg) with those obtained after administration of nifedipine cisapride (2.5 mg) in 20 patients with hypertension. The plasma nifedipine level was not altered by cisapride at one hour after administration, but was significantly increased at two (p < 0.01), three (p < 0.01), and four (p < 0.05) hours when compared with the level measured after nifedipine alone. Cisapride significantly decreased the mean blood pressure at three hours (p < 0.05) after administration of nifedipine. The acetaminophen method was used to determine gastric emptying time. The plasma concentration of acetaminophen at 45 minutes after administration was significantly increased by cisapride, suggesting that enhanced gastrointestinal motility might be the basis for the increase in the plasma nifedipine concentration. These results suggest that enhancement of the antihypertensive effect of nifedipine can occur when the drug is prescribed with cisapride, and that caution is needed when using such a combination therapy.
Satoh
C
C
Department of Internal Medicine (IV), Jikei University School of Medicine, Tokyo.
Sakai
T
T
Kashiwagi
H
H
Hongo
K
K
Aizawa
O
O
Watanabe
H
H
Mochizuki
S
S
Okamura
T
T
D000368:Aged; D002121:Calcium Channel Blockers / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D020117:Cisapride; D003692:Delayed-Action Preparations; D004347:Drug Interactions; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D010880:Piperidines / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D003692:Delayed-Action Preparations; D005765:Gastrointestinal Agents; D010880:Piperidines; D009543:Nifedipine; D020117:Cisapride