title: An alternative method of nitrous oxide delivery into a minimal-flow circle breathing system.
abstract: We have sought to define a way in which nitrous oxide can be safely and universally used at minimal to low flows by utilising a circle system with a controlled leak provided by a standard gas analyser sampling line and a fresh gas supply of 50% nitrous oxide in oxygen, entering from a trunk interposed between the ventilator and the circle system. Although preliminary calculations suggested that this arrangement was likely to work, it was found that 13 of 23 patients studied prospectively developed an inspired oxygen fraction below 0.3. We conclude that, although this arrangement provides a new means of introducing nitrous oxide into the circle breathing system, it does not appear inherently safer or more convenient than the conventional route.
authors.affiliation: Magill Department of Anaesthetics, Chelsea and Westminster Hospital, London, UK.
authors.forename: M R
authors.initials: MR
authors.lastname: Nel
authors.forename: J D
authors.initials: JD
authors.lastname: Watts
authors.forename: G G
authors.initials: GG
authors.lastname: Lockwood
mesh_terms: D000764:Anesthesia, Closed-Circuit / Q000295:instrumentation* / Q000379:methods; D000769:Anesthesia, Inhalation / Q000379:methods; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D000077335:Desflurane; D004334:Drug Administration Schedule; D006801:Humans; D007530:Isoflurane / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D009609:Nitrous Oxide / Q000008:administration & dosage*; D010100:Oxygen / Q000008:administration & dosage; D011446:Prospective Studies
chemical_list: D018685:Anesthetics, Inhalation; D000077335:Desflurane; D007530:Isoflurane; D009609:Nitrous Oxide; D010100:Oxygen