Expression of the amiloride-sensitive sodium channel beta subunit gene in human B lymphocytes.
The amiloride-sensitive, epithelial sodium channel (ENaC) is composed of at least three subunits (alpha, beta, and gamma). This study demonstrates that the ENaC beta subunit gene is expressed in human B cell lines, peripheral blood lymphocytes, and lymph node at the mRNA level. Further, this study shows that both wild-type and mutated alleles of the ENaC beta subunit gene are transcribed in human B lymphocytes derived from an individual affected with Liddle's syndrome, an autosomal dominant form of human hypertension.
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Department of Medicine, University of Alabama at Birmingham 35294, USA.
Warnock
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D000483:Alleles; D000584:Amiloride / Q000494:pharmacology; D001402:B-Lymphocytes / Q000378:metabolism*; D002460:Cell Line; D017931:DNA Primers / Q000737:chemistry; D004232:Diuretics / Q000494:pharmacology; D053503:Epithelial Sodium Channels; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000378:metabolism; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000096:biosynthesis; D015222:Sodium Channels / Q000096:biosynthesis* / Q000187:drug effects / Q000235:genetics; D013577:Syndrome; D014158:Transcription, Genetic
D017931:DNA Primers; D004232:Diuretics; D053503:Epithelial Sodium Channels; D012333:RNA, Messenger; C507048:SCNN1B protein, human; D015222:Sodium Channels; D000584:Amiloride