Role of the beta3-adrenoceptor in the control of leptin expression.
The inhibitory effect of beta-adrenoceptor agonists on leptin expression in brown and white adipose tissues is now well documented both in vivo and in vitro. It suggests the existence in vivo of a retroregulatory loop by which leptin inhibits its own expression via the sympathetic nervous system and the beta3-adrenoceptor. The hypothesis that the defect in beta3-adrenoceptor described in the adipose tissue of hereditary obese rodents can contribute to the resistance to leptin and to the increase in leptin expression observed in these animals is discussed.
Giacobino
J P
JP
Département de Biochimie Médicale, Centre Médical Universitaire, Genève, Switzerland.
D000222:Adaptation, Physiological; D000818:Animals; D003080:Cold Temperature; D005786:Gene Expression Regulation; D006801:Humans; D020738:Leptin; D009765:Obesity; D011506:Proteins / Q000235:genetics*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D054411:Receptors, Leptin
C515448:LEPR protein, human; D020738:Leptin; D011506:Proteins; D011943:Receptors, Adrenergic, beta; D054411:Receptors, Leptin