Physicochemical and pathophysiological factors in the release of membrane-bound alkaline phosphatase from cells.
Alkaline phosphatase is bound to cell membranes by a glycan phosphatidylinositol anchoring domain. The structure of this domain and ways in which it may be cleaved by chemical and enzymatic means provide a basis for understanding the solubilization of alkaline phosphatase from tissues in vitro and in vivo and the generation of isoforms.
Moss
D W
DW
Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
D000469:Alkaline Phosphatase / Q000737:chemistry* / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000737:chemistry / Q000201:enzymology* / Q000378:metabolism*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006801:Humans
D000469:Alkaline Phosphatase