title: [Surgery of primary malignant melanomas of the mucosa of the nasal fossa and facial sinuses].
abstract: A retrospective analysis of 22 patients with primary malignant melanoma of the nasal fossa and/or paranasal sinuses consecutively managed with surgery at our department from 1975 to 1993 was conducted. Fifteen patients had negative margins of resection. Neoadjuvant chemotherapy and post-operative radiation therapy was associated in 4 and 5 of these 15 patients, respectively. Four patients had positive margins. Adjunctive treatment was chemotherapy and postoperative radiation therapy in 2 and 3 of these 4 patients, respectively. The remaining 3 patients were managed with palliative treatment (debulking surgery and chemotherapy). No patients were lost to follow up. A 3-year follow-up was always achieved. In patients in whom surgical resection achieved negative margins, the 5-year actuarial survival, and local control estimate was 17.9%, and 26.9%, respectively. None of the variables under analysis were statistically related to local recurrence or survival. Death always occurred within 24 months from initial diagnosis in all 7 patients but one in whom surgical resection with negative margins was not achieved or debulking surgery was performed.
authors.affiliation: Service d'Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale, Hôpital Laennec, Assistance Publique des Hópitaux de Paris, Université Paris V.
authors.forename: O
authors.initials: O
authors.lastname: Laccourreye
authors.forename: I
authors.initials: I
authors.lastname: Wagner
authors.forename: R
authors.initials: R
authors.lastname: Cauchois
authors.forename: V
authors.initials: V
authors.lastname: Jouffre
authors.forename: W
authors.initials: W
authors.lastname: Shen
authors.forename: D
authors.initials: D
authors.lastname: Brasnu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000401:mortality / Q000601:surgery*; D008875:Middle Aged; D009297:Nasal Mucosa; D009669:Nose Neoplasms / Q000601:surgery*; D010255:Paranasal Sinus Neoplasms / Q000401:mortality / Q000601:surgery*; D012189:Retrospective Studies