title: Increased expression of cardiac phosphatases in patients with end-stage heart failure.
abstract: Type 1 phosphatase activity was increased in membrane vesicles from failing human ventricles compared with non-failing controls. Likewise, expression of the mRNA encoding for type 1 phosphatase was enhanced by 37%. The present study provides evidence that alterations of phosphatase activity coincide with end-stage heart failure. Thus, enhanced activity of phosphatases may be causally related to heart failure and/or may aggravate the well known decreased cardiac responsiveness to positive inotropic agents in end-stage heart failure.
authors.affiliation: Institut für Pharmakologie und Toxikologie der Westfälischen Wilhelms-Universität, Münster, FRG.
authors.forename: J
authors.initials: J
authors.lastname: Neumann
authors.forename: T
authors.initials: T
authors.lastname: Eschenhagen
authors.forename: L R
authors.initials: LR
authors.lastname: Jones
authors.forename: B
authors.initials: B
authors.lastname: Linck
authors.forename: W
authors.initials: W
authors.lastname: Schmitz
authors.forename: H
authors.initials: H
authors.lastname: Scholz
authors.forename: N
authors.initials: N
authors.lastname: Zimmermann
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism; D000328:Adult; D000818:Animals; D015152:Blotting, Northern; D002311:Cardiomyopathy, Dilated / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D006352:Heart Ventricles / Q000378:metabolism*; D006801:Humans; D008297:Male; D008566:Membranes / Q000378:metabolism; D008875:Middle Aged; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics*; D051381:Rats
chemical_list: D010744:Phosphoric Monoester Hydrolases; D000262:Adenylyl Cyclases