title: 2-Aryl-6-methyl-3-phenylamino-6,7-dihydropyrano[4,3-c]pyrazol-4(2H)-ones with analgesic activity.
abstract: A series of 2-aryl-6-methyl-3-phenylamino-6,7-dihydropyrano[4,3-c]pyrazol-4(2H )-ones were prepared and tested for antiinflammatory, analgesic, antipyretic, antiarrhythmic, antihypertensive and platelet antiaggregating activities. All of them showed an appreciable level of analgesic activity in mice.
authors.affiliation: Istituto di Scienze Farmaceutiche dell'Università, Genova.
authors.forename: O
authors.initials: O
authors.lastname: Bruno
authors.forename: S
authors.initials: S
authors.lastname: Schenone
authors.forename: A
authors.initials: A
authors.lastname: Ranise
authors.forename: F
authors.initials: F
authors.lastname: Bondavalli
authors.forename: G
authors.initials: G
authors.lastname: Falcone
authors.forename: W
authors.initials: W
authors.lastname: Filippelli
authors.forename: I
authors.initials: I
authors.lastname: Marabese
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D051379:Mice; D011720:Pyrazoles / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D018712:Analgesics, Non-Narcotic; D011720:Pyrazoles