title: Ferumoxides and Tc-99m sulfur colloid: comparison of the tumor-to-liver uptake in focal nodular hyperplasia.
abstract: The tumor-to-liver uptake of two reticuloendothelial agents, namely ferumoxides and technetium-99m (Tc-99m) sulfur colloid, was compared in focal nodular hyperplasia (FNH). Twelve patients with FNH who had undergone ferumoxides-enhanced MR imaging and planar Tc-99m sulfur colloid scintigraphy within 1 year were included from the study. Fourteen patients with FNH with a diameter larger than 3 cm were selected for the comparison. The tumor-to-liver ferumoxides uptake was calculated and the Tc-99m sulfur colloid uptake was assessed visually. Fermuoxides uptake was observed in all but one patient with FNH (mean tumor-to-liver ratio = .36). The six tumors showing normal (n = 5) or increased (n = 1) radiocolloid uptake when compared to the liver accumulated more ferumoxides than the eight tumors showing decreased radiocolloid uptake (P < .01). However, in some tumors, no direct relation was observed between ferumoxides and Tc-99m sulfur colloid uptake. Our observations suggest that ferumoxides uptake might not exactly mimic Tc-99m sulfur colloid uptake in FNH.
authors.affiliation: Department of Radiology, St. Luc University Hospital, Catholic University of Louvain, Brussels, Belgium.
authors.forename: C B
authors.initials: CB
authors.lastname: Grandin
authors.forename: B E
authors.initials: BE
authors.lastname: Van Beers
authors.forename: S
authors.initials: S
authors.lastname: Pauwels
authors.forename: R
authors.initials: R
authors.lastname: Demeure
authors.forename: J
authors.initials: J
authors.lastname: Jamart
authors.forename: J
authors.initials: J
authors.lastname: Pringot
mesh_terms: D000328:Adult; D003287:Contrast Media / Q000493:pharmacokinetics*; D003911:Dextrans; D003937:Diagnosis, Differential; D005260:Female; D052203:Ferrosoferric Oxide; D006801:Humans; D006965:Hyperplasia / Q000175:diagnosis; D007089:Image Enhancement / Q000379:methods; D007501:Iron / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism*; D008107:Liver Diseases / Q000175:diagnosis* / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles; D008297:Male; D008875:Middle Aged; D010087:Oxides / Q000493:pharmacokinetics*; D012680:Sensitivity and Specificity; D013667:Technetium / Q000493:pharmacokinetics*
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; D013667:Technetium; D007501:Iron; C065507:ferumoxides; D052203:Ferrosoferric Oxide