[Experimental use of a cytostatic and a corticosteroid on a collagen implant in surgery for glaucoma].
Clinical and morphologic studies of local application of a cytostatic (5-fluorouracyl) and a corticosteroid (dexasone) on a collagen implant in filtration surgery for glaucoma were carried out. The velocity of regression of filtration cushion (FC), intraocular pressure, and local connective tissue reaction after sinusotrabeculectomy with collagen implant were examined in 30 rabbit eyes. Impregnation of the implant with the preparations prolonged 3-fold the period of FC existence in comparison with the control. The cytostatic 1.5 to 2 times reduced the inflammatory infiltration and fibroblast proliferation in the wound, this creating optimal conditions for the formation of functionally competent discharge canals.
Batmanov
I E
IE
Department of Eye Diseases, Russian State Medical University, Moscow.
Ziangirova
G G
GG
Kolesnikova
L N
LN
Fink
E K
EK
D000287:Administration, Topical; D000818:Animals; D000963:Antimetabolites / Q000008:administration & dosage*; D017024:Chemotherapy, Adjuvant; D002682:Chinchilla; D003094:Collagen; D003907:Dexamethasone / Q000008:administration & dosage*; D004343:Drug Implants; D005472:Fluorouracil / Q000008:administration & dosage*; D005901:Glaucoma / Q000188:drug therapy / Q000601:surgery*; D005938:Glucocorticoids / Q000008:administration & dosage*; D007429:Intraocular Pressure; D011817:Rabbits; D014130:Trabeculectomy / Q000379:methods; D014945:Wound Healing / Q000187:drug effects
D000963:Antimetabolites; D004343:Drug Implants; D005938:Glucocorticoids; D003907:Dexamethasone; D003094:Collagen; D005472:Fluorouracil