title: Atypical, severe toxoplasmic retinochoroiditis in elderly patients.
abstract: BACKGROUND
  The diagnosis of toxoplasmic retinochoroiditis is based primarily on characteristic ocular findings, with supportive serologic evidence. Clinical recognition of atypical presentations is critical for timely antiparasitic drug therapy.
  
  
  METHODS
  Case histories were reviewed for seven presumed immunocompetent elderly patients with atypically severe (multifocal or diffuse or both) toxoplasmic retinochoroiditis. Three cases initially were misdiagnosed as acute retinal necrosis syndrome. The correct diagnosis was confirmed in each case by response to antiparasitic drug therapy, polymerase chain reaction studies of intraocular specimens, or histopathologic analysis.
  
  
  RESULTS
  The patients ranged in age from 69 to 82 years (median, 74 years). Only three patients had intercurrent medical conditions that may be associated with subtle immune dysfunction (diabetes mellitus and hepatitis C). The extensive necrotizing retinochoroiditis in each patient was nonhemorrhagic and not associated with occlusive retinal arteritis. Despite prompt response to antiparasitic drug therapy, prolonged treatment usually was required, and four patients had retinitis reactivation after discontinuing treatment. Significant visual loss accompanied the infection in most eyes.
  
  
  CONCLUSIONS
  Toxoplasmosis should be considered as a cause of multifocal or diffuse necrotizing retinitis or both in elderly patients. Older patients may be more susceptible to severe ocular Toxoplasma infections because of age-related decline in cell-mediated immunity and chronic underlying diseases.
authors.affiliation: W.K. Kellogg Eye Center, Department of Ophthalmology, University of Michigan School of Medicine, Ann Arbor 48105, USA.
authors.forename: M W
authors.initials: MW
authors.lastname: Johnson
authors.forename: G M
authors.initials: GM
authors.lastname: Greven
authors.forename: G J
authors.initials: GJ
authors.lastname: Jaffe
authors.forename: H
authors.initials: H
authors.lastname: Sudhalkar
authors.forename: A K
authors.initials: AK
authors.lastname: Vine
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D002825:Chorioretinitis / Q000175:diagnosis* / Q000188:drug therapy / Q000469:parasitology; D003937:Diagnosis, Differential; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D015882:Retinal Necrosis Syndrome, Acute / Q000175:diagnosis; D014122:Toxoplasma / Q000276:immunology; D014126:Toxoplasmosis, Ocular / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D014792:Visual Acuity
chemical_list: D000913:Antibodies, Protozoan; D000981:Antiprotozoal Agents; D005938:Glucocorticoids