Visualisation of loss of 5-HT2A receptors with age in healthy volunteers using [18F]altanserin and positron emission tomographic imaging.
We used [18F]altanserin and positron emission tomography (PET) to image serotonin 5-HT2A receptors in humans. The highest [18F]altanserin uptake is found in the cerebral cortex, with specific-to-nonspecific binding ratios varying from 0.53 to 1.91 in humans between 24 and 48 years of age. In all neocortical regions studied, [18F]altanserin uptake correlates negatively with age. No correlations were found between age and uptake in the cerebellum, the regional cerebral blood flow, or the time course of metabolization of [18F]altanserin. The reduction in cerebral 5-HT2A receptor binding thus directly reflects the loss of specific 5-HT2A receptors with age.
Rosier
A
A
Laboratory for Neuro- and Psychophysiology, Medical School, K.U. Leuven, Belgium.
Dupont
P
P
Peuskens
J
J
Bormans
G
G
Vandenberghe
R
R
Maes
M
M
de Groot
T
T
Schiepers
C
C
Verbruggen
A
A
Mortelmans
L
L
D000328:Adult; D000375:Aging / Q000502:physiology*; D001921:Brain / Q000000981:diagnostic imaging*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000000981:diagnostic imaging; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D005462:Fluorine Radioisotopes; D006801:Humans; D007650:Ketanserin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D008297:Male; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000502:physiology*; D012016:Reference Values; D012702:Serotonin Antagonists / Q000493:pharmacokinetics*; D014055:Tomography, Emission-Computed
D005462:Fluorine Radioisotopes; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C071983:altanserin; D007650:Ketanserin