[Betamethasone Reference Standard (Control 951) of the National Institute of Health Sciences].
The raw material of betamethasone was tested for preparation of the "Betamethasone Reference Standard (Control 951)". Analytical data obtained were as follows: loss on drying, 0.0%; infrared spectrum, the same as that of the JP Betamethasone Reference Standard (Control 845); thin-layer chromatography, no impurity was detected; high-performance liquid chromatography (HPLC), two kinds of impurities were detected and the total amount was estimated to be 0.16 +/- 0.01% (n = 3); assay, 100.0% by HPLC. Based on the above results, the raw material was authorized as the JP Betamethasone Reference Standard (Control 951).
Kitajima
A
A
Maekawa
K
K
Yoshii
K
K
Komatsu
H
H
Tanimoto
T
T
Okada
S
S
D001623:Betamethasone / Q000032:analysis / Q000592:standards*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006077:Government Agencies; D007564:Japan; D010602:Pharmacopoeias as Topic / Q000592:standards; D012015:Reference Standards
D001623:Betamethasone