title: The use of single fraction Leksell stereotactic radiosurgery in the treatment of uveal melanoma.
abstract: Fourteen patients with posterior uveal melanomas were treated using single fraction stereotactic radiosurgery. In each case a dose of 70 Gy was administered to the periphery of the tumour. Regression of the tumour has been observed in 13 patients, whilst the lesion has remained unchanged in one patient. The visual acuity has deteriorated in all 14 patients. Significant radiation induced adverse reactions were noted in 13 patients and include; retinopathy, optic neuropathy, rubeosis iridis, and secondary glaucoma. Two patients have required enucleation because of intractable rubeotic glaucoma. One patient has died from proven metastases. Although stereotactic radiosurgery appears to be a practical and effective method of treating uveal melanomas, its usefulness is limited by a high incidence of radiation induced adverse reactions. Further work is required to refine the current treatment protocol and establish an optimal prescription dose.
authors.affiliation: Department of Ophthalmology and Orthoptics, University of Sheffield, UK.
authors.forename: I
authors.initials: I
authors.lastname: Rennie
authors.forename: D
authors.initials: D
authors.lastname: Forster
authors.forename: A
authors.initials: A
authors.lastname: Kemeny
authors.forename: L
authors.initials: L
authors.lastname: Walton
authors.forename: I
authors.initials: I
authors.lastname: Kunkler
mesh_terms: D000328:Adult; D000368:Aged; D005123:Eye / Q000528:radiation effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology; D011832:Radiation Injuries / Q000209:etiology; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods*; D012074:Remission Induction; D012189:Retrospective Studies; D016896:Treatment Outcome; D014604:Uveal Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D014792:Visual Acuity