Chronic administration of Oren-gedoku-to (TJ15) inhibits ischemia-induced changes in brain indoleamine metabolism and muscarinic receptor binding in the Mongolian gerbil.
We examined the effect of Oren-gedoku-to (TJ15), which is a traditional herbal Kampo prescription used as an anti-cerebral apoplexy agent on these changes. Chronic pre- and post-ischemia TJ15 oral administration almost completely abolished the ischemia-induced muscarinic receptor reduction and 5-hydroxyindoleacetic acid level increase. These results suggest that TJ15 prevents cholinergic synaptic dysfunction and serotonergic presynaptic hyperactivity induced by transient ischemia.
Kabuto
H
H
Department of Neuroscience, Okayama University Medical School, Japan.
Asanuma
M
M
Nishibayashi
S
S
Iida
M
M
Ogawa
N
N
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005849:Gerbillinae; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism*; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D016548:Prosencephalon / Q000098:blood supply; D011976:Receptors, Muscarinic / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors
D004365:Drugs, Chinese Herbal; D011976:Receptors, Muscarinic; C061676:oren gedoku to; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D000109:Acetylcholine