title: Efficacy of 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) on an ARC/AIDS rhesus macaque (Macaca mulatta) infected with simian immunodeficiency virus.
abstract: The efficacy of 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) was investigated in vivo by using a male ARC/AIDS rhesus macaque infected with simian immunodeficiency virus (SIVmac251/32H). He was administered subcutaneously 6-Cl-ddG (50 mg/kg B.W.) every 8 hr for 14 days when he showed clinical features of recurrent weight loss, severe diarrhea and neuropathy. The number of CD4+, CD8+ cells and total T cells increased rapidly after administration of 6-Cl-ddG and a high level was maintained for 2 months, but the B cell count decreased during the treatment. The antibody titer to SIV did not change significantly during or after the treatment, but the virus load in the plasma measured by RT-PCR dropped to one-third at the start of the 6-Cl-ddG treatment. Within 3 days after the start of 6-Cl-ddG administration, he began to show recovery in clinical signs including weight increase, and disappearance of diarrhea and neuropathy. These findings suggested that 6-Cl-ddG was effective at the stage of ARC/AIDS in a rhesus monkey infected with SIV.
authors.affiliation: Iwakuni Research Laboratory of Technology, Nippon Paper Industries Co., Ltd., Yamaguchi, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Fujii
authors.forename: R
authors.initials: R
authors.lastname: Mukai
authors.forename: Y
authors.initials: Y
authors.lastname: Murayama
authors.forename: H
authors.initials: H
authors.lastname: Akari
authors.forename: M
authors.initials: M
authors.lastname: Machida
authors.forename: K
authors.initials: K
authors.lastname: Mori
authors.forename: M
authors.initials: M
authors.lastname: Takasaka
authors.forename: K
authors.initials: K
authors.lastname: Murakami
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshikawa
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D018414:CD8-Positive T-Lymphocytes; D015224:Dideoxynucleosides / Q000627:therapeutic use*; D018655:Lymphocyte Count; D008253:Macaca mulatta; D008297:Male; D016097:Simian Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D015302:Simian Immunodeficiency Virus
chemical_list: C095793:6-chloro-2',3'-dideoxyguanosine; D000998:Antiviral Agents; D015224:Dideoxynucleosides