[Crystalline cholesterol as a factor in thrombus formation].
The model using crystalline cholesterol as the thrombogenic process inductor was developed. Thrombi that are morphologically equivalent to the human arterial thrombi under atherosclerosis were created in experiment on standard animals. It was shown that the "head" (conglutinational part) of such thrombi includes the thrombocyte mass, organised into the system of branched trabeculae surrounded by leucocytal limbus. The "caudal" (coagulational part) of the experimentally obtained thrombi consists of fibrin and erythrocytes. Data obtained make it possible to consider crystalline cholesterol of atheromatous plaques as the most probable trigger factor of thrombogenesis during atherosclerotic process.
Poliakov
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AE
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D002784:Cholesterol / Q000378:metabolism*; D003460:Crystallization; D004195:Disease Models, Animal; D008297:Male; D008854:Microscopy, Electron; D011817:Rabbits; D012756:Sheep; D013927:Thrombosis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology
D002784:Cholesterol