title: Dacryocystorhinostomy with intraoperative mitomycin C.
abstract: OBJECTIVE
  To observe the effect of intraoperative mitomycin C on the size of the osteotomy site after dacryocystorhinostomy.:
  
  
  METHODS
  A total of 15 eyes of 14 patients diagnosed with primary acquired nasolacrimal duct obstruction were assigned randomly to either a mitomycin C group or a control group. The surgical procedures in both groups were exactly the same, except that in the patients in the mitomycin C group, a piece of neurosurgical cottonoid soaked with 0.2 mg/ml mitomycin C was applied to the osteotomy site and then after 30 minutes was removed transnasally. Nasoendoscopic findings were recorded at the completion of the surgery and at 1 month, 3 months, and 6 months after surgery for the two groups. A computer-aided digitizer was used to calculate the surface area of the osteotomy site, and a Student's t test was used to compare the difference between the two groups.
  
  
  RESULTS
  All patients in the mitomycin C group remained symptom free after removal of their silicone tube (100% success), and there was one patient in the control group who had recurrent epiphora (87.5% success). Septo-osteotomy adhesion was found in two patients in the control group (25%), but there was no such adhesion found in the patients in the mitomycin C group. In the mitomycin C group, the average final surface area of the osteotomy at the end of the sixth postoperative month was 27.10 +/- 5.78 mm2, whereas that of the control group was only 10.83 +/- 3.37 mm2. Although the immediate postoperative surface area of the osteotomy showed no significant difference between the two groups, a statistically significant difference was noted at 6 months.
  
  
  CONCLUSIONS
  Intraoperative mitomycin C is effective in maintaining a larger osteotomy size. This modification may possibly improve success rates over the traditional dacryocystorhinostomy procedure.
authors.affiliation: Department of Ophthalmology, National Taiwan University Hospital, Taipei.
authors.forename: S C
authors.initials: SC
authors.lastname: Kao
authors.forename: C L
authors.initials: CL
authors.lastname: Liao
authors.forename: J H
authors.initials: JH
authors.lastname: Tseng
authors.forename: M S
authors.initials: MS
authors.lastname: Chen
authors.forename: P K
authors.initials: PK
authors.lastname: Hou
mesh_terms: D017024:Chemotherapy, Adjuvant; D003608:Dacryocystorhinostomy; D005500:Follow-Up Studies; D006801:Humans; D007430:Intraoperative Care; D007767:Lacrimal Duct Obstruction / Q000188:drug therapy; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D009301:Nasolacrimal Duct / Q000187:drug effects / Q000601:surgery*; D019384:Nucleic Acid Synthesis Inhibitors / Q000008:administration & dosage*; D010030:Ostomy; D016896:Treatment Outcome
chemical_list: D019384:Nucleic Acid Synthesis Inhibitors; D016685:Mitomycin