Isolation and structure of ciguatoxin-4A, a new ciguatoxin precursor, from cultures of dinoflagellate Gambierdiscus toxicus and parrotfish Scarus gibbus.
A new ciguatoxin congener, ciguatoxin-4A (CTX4A), was isolated from cultures of marine dinoflagellate Gambierdiscus toxicus, and its structure was elucidated to be 52-epiciguatoxin-4B on the basis of spectroscopic data. Chromatographic and spectral comparisons indicated that CTX4A was identical with a structurally unelucidated congener known as scaritoxin or SG1.
Satake
M
M
Faculty of Agriculture, Tohoku Univeristy, Sendai, Japan.
Ishibashi
Y
Y
Legrand
A M
AM
Yasumoto
T
T
D000818:Animals; D002240:Carbohydrate Sequence; D002478:Cells, Cultured; D056890:Eukaryota / Q000737:chemistry*; D005399:Fishes / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008969:Molecular Sequence Data; D013056:Spectrophotometry, Ultraviolet