Effect of TYB-2285 on lung anaphylaxis in actively sensitized rats.
1. We examined the effect of TYB-2285 on the acute phase and the late phase of lung anaphylaxis in rats. 2. TYB-2285 (3-30 mg/kg PO) inhibited antigen-induced bronchoconstriction and TxB2 production during the acute phase of lung anaphylaxis in a dose-dependent manner. 3. Ketotifen fumarate (30 mg/kg p.o.) inhibited bronchoconstriction and TxB2 production less potently than TYB-2285. 4. TYB-2285 (30 mg/kg p.o.) inhibited the accumulation of neutrophils during the late phase of lung anaphylaxis significantly without a significant change in total cells. 5. Hydrocortisone acetate (100 mg/kg p.o.) inhibited the accumulation of total cells as potent as neutrophils.
Watanabe
A
A
Department of Pharmacology, Toyobo Co. Ltd., Shiga, Japan.
Tominaga
T
T
Shutoh
H
H
Hayashi
H
H
Tsuji
J
J
Koda
A
A
Nagai
H
H
Kumazawa
Y
Y
Shimada
H
H
D000707:Anaphylaxis / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000941:Antigens / Q000276:immunology; D016084:Bronchoconstriction / Q000187:drug effects / Q000276:immunology; D006854:Hydrocortisone / Q000494:pharmacology; D007665:Ketotifen / Q000494:pharmacology; D008168:Lung / Q000187:drug effects* / Q000276:immunology / Q000503:physiopathology; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D009570:Nitriles / Q000494:pharmacology*; D010047:Ovalbumin / Q000276:immunology / Q000494:pharmacology; D051381:Rats; D013929:Thromboxane B2 / Q000097:blood / Q000276:immunology
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000941:Antigens; D009570:Nitriles; C081050:3,5-bis(acetoxyacetylamino)-4-chlorobenzonitrile; D013929:Thromboxane B2; D010047:Ovalbumin; D006854:Hydrocortisone; D007665:Ketotifen