title: [Why is iodine deficiency once again present in the Berne region?].
abstract: Owing to the progressive iodination of salt in Switzerland (5, 10, 20 mg KI/kg in the years 1922, 1965, 1980), iodine deficiency in former endemic goiter regions had nearly disappeared. In several areas of the country, urinary iodine had increased from below 30 micrograms/24 h (1920) to > 100 micrograms/g creatinine (1981-1990). In 1991-1992, however, the 24-h-iodinuria in a subgroup of 160 examinations out of a total of 289 persons in Berne was again insufficient (norm > 150 micrograms J/24 h): mean 121 micrograms/24 h (82 micrograms/l), median 107.8 micrograms/24 h (67 micrograms/l). Follow-up of one proband in 1991-1992 (n = 9) and 1996 (n = 11) yielded average 24-h-iodinurias in the slightly deficient domain of (mean +/- SD) 104 +/- 57 micrograms/ 24 h (75 +/- 30 micrograms/l) and 103 +/- 27 micrograms/24 h (44 +/- 17 micrograms/l) respectively, with a wide range (45-258 micrograms l/24 h globally). Possible reasons for the decreasing iodide intake in recent years, resulting in the 1990s in a marginally deficient supply, are reduced intake of salt in recent decades, increased consumption of foodstuffs prepared with non-iodized salt, dietary diversification, and frequent meals away from the family table. Therefore, intake of non-iodized salt should be avoided in Switzerland.
authors.affiliation: Abteilung Nuklearmedizin, Inselspital, Universität Bern.
authors.forename: C
authors.initials: C
authors.lastname: Als
authors.forename: D
authors.initials: D
authors.lastname: Lüscher
authors.forename: H
authors.initials: H
authors.lastname: Gerber
authors.forename: L
authors.initials: L
authors.lastname: Brander
authors.forename: K
authors.initials: K
authors.lastname: Lauber
authors.forename: H
authors.initials: H
authors.lastname: Rösler
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D006043:Goiter, Endemic / Q000517:prevention & control*; D006801:Humans; D007037:Hypothyroidism / Q000652:urine; D007455:Iodine / Q000652:urine*; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013557:Switzerland; D013961:Thyroid Gland / Q000528:radiation effects; D013965:Thyroidectomy
chemical_list: D007457:Iodine Radioisotopes; D007455:Iodine