Presence of the bcr/abl rearrangement in a patient with chronic neutrophilic leukaemia.
An 83 year old women presented with a myeloproliferative disorder involving the myeloid and megakaryocytic lines, and characterised by mature neutrophil leucocytosis. There was a high/normal neutrophil alkaline phosphatase activity and absence of the Philadelphia chromosome, features compatible with a diagnosis of chronic neutrophilic leukaemia (CNL). Southern blot analysis of the patient's DNA revealed the presence of the bcr/abl rearrangement. Combined with a previous report of detection of Ph1 chromosome in long term bone marrow cultures in a patient with CNL, this finding suggests that the bcr/abl hybrid gene might occasionally result in a myeloproliferative disorder with a phenotype closely resembling that of CNL.
Christopoulos
C
C
First Department of Internal Medicine, Agia Olga Hospital, Athens, Greece.
Kottoris
K
K
Mikraki
V
V
Anevlavis
E
E
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D006801:Humans; D015467:Leukemia, Neutrophilic, Chronic / Q000235:genetics*
D016044:Fusion Proteins, bcr-abl