Significance of the expression of hormone receptors and of p53 protein in breast carcinomas.
A certain proportion of breast cancers contain hormone receptors--specific proteins with high affinity and capacity of selective tie of these hormones. There were selected 30 patients presenting breast cancer, treated at the surgical departments from the County Hospital of Timişoara between 1993 and 1995. The identification of hormone receptors was done on 10% formalin-fixed and paraffin-embedded tissue specimens. As anti-hormone receptors, monoclonal and polyclonal antibodies were used. The immunohistochemical identification of positive to hormone receptors cancer cells was obtained, by nucleus staining. Immunohistochemical assay of the accumulation of p53 protein seems to be an efficient means of selecting breast neoplasms. p53 immunostaining is positive at the level of malignant cells' nuclei and negative for normal cells. From the 30 breast carcinomas, 19 (63.3%) were ER+ and 15 (49.9%) were PR+, resulting an increase of the frequency of ER+ tumors together with the age of the patients; 9 cases (30%) expressed p53 protein, harmonizing with the data in the literature.
Roşianu
A
A
Dept. of Morphopatology, University of Medicine and Pharmacy, Timişoara.
Tudose
N
N
Potencz
E
E
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000737:chemistry*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000032:analysis*; D012189:Retrospective Studies; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
D011956:Receptors, Cell Surface; D016159:Tumor Suppressor Protein p53