title: Repeat hepatic resection for recurrent colorectal cancer.
abstract: Recurrence in the liver following hepatic resection for metastatic colorectal carcinoma is a predictable phenomenon, occurring in about two-thirds of patients who develop recurrence. There are few data, however, about the value of repeated hepatic resection in patients who have a recurrence in the liver following initial resection of their hepatic metastases. We have reviewed our experience with 10 patients (of whom 9 were evaluable), culled from a series of 74 patients who had an initial hepatic resection for metastatic colorectal carcinoma. There were seven men and two women, mean age 52 (range 34-75 years). Duke's stages of the primary cancer were B1 in two patients, B2 in one patient, and C2 in six patients. Most of the patients had elevated carcinoembryonic antigen (CEA) and constitutional symptoms as indications for the second-look procedure. There was one surgical death due to hepatic failure in a patient who required a trisegmentectomy. The average interval between the first and second hepatic resections was 21 months. The estimated 1- and 5-year actuarial survivals from the second liver resection were 78% and 23%, respectively. The median survival was 41 months from the first resection (range 14-100 months) and 16 months from the second resection (range 0-92 months). In conclusion, repeat hepatectomy for recurrent liver metastases is a viable option for the well selected patient. It is a low risk surgical procedure and may augment survival in the patient with well documented metastases limited to the liver.
authors.affiliation: Department of Surgery, Brown University School of Medicine, Roger Williams Medical Center, 825 Chalkstone Avenue, Providence, Rhode Island 02908-4735, U.S.A.
authors.forename: Q D
authors.initials: QD
authors.lastname: Chu
authors.forename: M P
authors.initials: MP
authors.lastname: Vezeridis
authors.forename: K A
authors.initials: KA
authors.lastname: Avradopoulos
authors.forename: H J
authors.initials: HJ
authors.lastname: Wanebo
mesh_terms: D000328:Adult; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D012086:Reoperation; D015996:Survival Rate; D013997:Time Factors