An epitope in the third hypervariable region of the DRB1 gene is involved in the susceptibility to endemic pemphigus foliaceus (fogo selvagem) in three different Brazilian populations.
Endemic pemphigus foliaceus or fogo selvagem (FS) in an organ-specific autoimmune skin disease characterized by epidermal vesicles and mediated by autoantibodies. Family cases are frequent and not everyone living in endemic region develops FS suggesting that host factors play a role in determining whether exposed individuals will be affected. Because our previous works with Brazilian Mestizos and with Xavante Indians have shown that particular HLA alleles confer increased risk for the disease, we decided to extend these studies to another homogeneous population, the Terena Indians. 19 out of 20 Terena patients were either positive for DRB1*0404, 1402 or 1406 (p < 0.005, RR = 14). These findings were in agreement with the data obtained from the Xavante study. In Mestizos the association was with DRB1*01. All these alleles involved in predisposition to the disease in different populations shared the same amino acid sequence at position 67-74 on the third hypervariable region of the DRB1 gene: LLEQRRAA, suggesting that inheritance of this sequence is involved in the susceptibility to FS. When patients and controls data from different studies were pooled and analyzed disregarding the ethnic background and the HLA alleles involved, the results obtained clearly supported the hypothesis that matching for this epitope is highly significant and predictive of FS predisposition (p < 0.00001, RR = 6.4).
Moraes
M E
ME
Fundação Pro-Sangue/Hemocentro de São Paulo, Brazil.
Fernandez-Vina
M
M
Lazaro
A
A
Diaz
L A
LA
Filho
G H
GH
Friedman
H
H
Rivitti
E
E
Aoki
V
V
Stastny
P
P
Moraes
J R
JR
D000483:Alleles; D001938:Brazil / Q000453:epidemiology; D004198:Disease Susceptibility / Q000276:immunology; D019353:Endemic Diseases; D000939:Epitopes / Q000235:genetics*; D005787:Gene Frequency; D006684:HLA-DR Antigens / Q000235:genetics* / Q000276:immunology; D059811:HLA-DRB1 Chains; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D010392:Pemphigus / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D044465:White People / Q000235:genetics
D000939:Epitopes; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains