[The results of an experimental study of an anti-Opisthorchis preparation made from plant raw material].
Agents and biologically active fractions derived from medical plants grown in Siberia were tested in vitro and in vivo. The extract from the aspen bark displayed the highest antiopisthorchiatic activity. This agent given at a concentration of 10(-3) caused 100% death of Opisthorchis 72 hours later. In golden hamster experiments, the efficiency of the aspen bark extract was 73.48-83.0%. Butanolic and ethylacetatic extracts were found to have the greatest antiopisthorchiatic activity. The results of chemical and chromatographic studies indicated that active fractions contained salicine and its derivatives. The aspen bark extract produces no substantial toxic effect on laboratory animals and belongs to the class "Low-toxic substances".
Mefod'ev
V V
VV
Krasnov
E A
EA
Stepanova
T F
TF
Sozonova
T A
TA
D000818:Animals; D000980:Antiplatyhelmintic Agents / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical; D007928:Lethal Dose 50; D008297:Male; D008647:Mesocricetus; D051379:Mice; D009889:Opisthorchiasis / Q000188:drug therapy / Q000469:parasitology; D009891:Opisthorchis / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D011223:Praziquantel / Q000031:analogs & derivatives / Q000627:therapeutic use; D051381:Rats; D012800:Siberia; D013997:Time Factors; D014197:Trees; D014992:Xylenes / Q000627:therapeutic use
D000980:Antiplatyhelmintic Agents; D010936:Plant Extracts; D014992:Xylenes; C078071:azinox; D011223:Praziquantel; C000294:hexachloro-4-xylene