[Immunological studies on cataracts under conditions of exposure to low-dose radiation].
Immunopathological changes were studied in cataract patients chronically exposed to low-dose ionizing radiation occupationally or as a result of living in districts polluted with radionuclides after the Chernobyl accident. No cellular autoimmune shifts were detected in the examinees; humoral autoimmune changes in respect of different ocular antigens were revealed. Low-dose ionizing radiation was conducive to the formation of thermostable complement-fixing antibodies to lens tissues. One of the causes of the production of such antibodies were disorders in the helper-suppressor relationships of T-lymphocytes. The studies confirm the hypothesis on the possibility of cataract development as a result of low-dose exposure.
Shubik
V M
VM
NII of Radiation Medicine, Saint-Petersburg.
Kvasova
M D
MD
D000293:Adolescent; D000328:Adult; D000917:Antibody Formation / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D002386:Cataract / Q000209:etiology / Q000276:immunology*; D002648:Child; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007908:Lens, Crystalline / Q000276:immunology* / Q000528:radiation effects; D008875:Middle Aged; D009784:Occupational Diseases / Q000209:etiology / Q000276:immunology*; D016273:Occupational Exposure / Q000009:adverse effects; D011210:Power Plants; D011832:Radiation Injuries / Q000209:etiology / Q000276:immunology*; D011839:Radiation, Ionizing; D018788:Radioactive Hazard Release; D014455:Ukraine
D001323:Autoantibodies