MHC class I and class II structures.
The basic structures of MHC class I and class II molecules are now well established. Over the past twelve months structural data on MHC class I molecules have provided details of the peptide binding groove for a number of alleles and have elaborated the mechanisms that allow binding of a range of peptides. Recent MHC class II structures have illustrated the mode of peptide binding both in mature complexes and in the MHC class II complex with a fragment of invariant chain (CLIP) during maturation.
Jones
E Y
EY
Laboratory of Molecular Biophysics, The Rex Richards Building, South Parks Road, Oxford OX1 3QU, UK. yvon@biop.ox.ac.uk
D000818:Animals; D015395:Histocompatibility Antigens Class I / Q000737:chemistry*; D000949:Histocompatibility Antigens Class II / Q000737:chemistry*; D006801:Humans; D011487:Protein Conformation; D013329:Structure-Activity Relationship
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II