Mapping abnormal synovial vascular permeability in temporomandibular joint arthritis in the rabbit using MRI.
An automated method for two-dimensional spatial depiction (mapping) of quantitative physiological tissue characteristics derived from contrast-enhanced MRI was applied to a model of inflammatory disease represented by antigen-induced arthritis of the temporomandibular joint in the rabbit. Specifically, an established two-compartment kinetic model of unidirectional mass transport was implemented on a pixel-by-pixel basis to generate maps of tissue permeability surface area product (PS) and fractional blood volume (BV) based on dynamic MRI intensity data after administration of albumin-(Gd-DTPA)30, a prototype macromolecular contrast medium designed for blood pool enhancement. Maps of PS and BV in a disease model of induced arthritis clearly depicted zones of increased permeability (up to approximately 200 microliters/cc/h-compared to 25 microliters/cc/h in normal tissues).
Demsar
F
F
Department of Radiology, University of California, San Francisco, USA.
Van Dijke
C F
CF
Kirk
B A
BA
Kapila
S
S
Peterfy
C G
CG
Roberts
T P
TP
Shames
D M
DM
Tomazic
S
S
Mann
J
J
Brasch
R C
RC
D000818:Animals; D001168:Arthritis / Q000473:pathology*; D002199:Capillary Permeability; D004195:Disease Models, Animal; D008279:Magnetic Resonance Imaging; D008297:Male; D011817:Rabbits; D013583:Synovial Membrane / Q000098:blood supply*; D013704:Temporomandibular Joint / Q000473:pathology*