Adenosine and neuronal plasticity.
Adenosine is considered an important neuromodulator of the nervous system acting at pre-, post- and non-synaptic levels. In the present review we describe how adenosine modifies paired-pulse facilitation (PPF), posttetanic depression (PTD), long-term potentiation (LTP), long-term depression (LTD) and depotentiation at the hippocampus, and therefore how this nucleoside modulates synaptic plasticity.
de Mendonça
A
A
Laboratory of Pharmacology, Gulbenkian Institute of Science, Oeiras, Portugal.
Ribeiro
J A
JA
D000241:Adenosine / Q000037:antagonists & inhibitors / Q000502:physiology*; D000818:Animals; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology*; D014970:Xanthines / Q000494:pharmacology
D014970:Xanthines; C051360:1,3-dipropyl-8-cyclopentylxanthine; D000241:Adenosine