DIR: a novel DNA rearrangement associated with inverted repeats.
A novel DNA rearrangement has been characterised that is both a direct and inverted repeat. This rearrangement involves the 2-fold duplication of a plasmid sequence adjacent to the site of insertion of a long palindrome. The sequence of this rearrangement suggests that it has arisen by strand slippage from the leading to the lagging strand of the replication fork as a consequence of the presence of the long palindrome.
Pinder
D J
DJ
Institute of Cell and Molecular Biology, University of Edinburgh, Kings Buildings, Edinburgh EH9 3JR, UK.
Blake
C E
CE
Leach
D R
DR
D015245:Deoxyribonuclease BamHI / Q000378:metabolism; D015246:Deoxyribonuclease EcoRI / Q000378:metabolism; D004587:Electrophoresis, Agar Gel; D004591:Electrophoresis, Polyacrylamide Gel; D015321:Gene Rearrangement; D016254:Mutagenesis, Insertional; D010957:Plasmids; D012091:Repetitive Sequences, Nucleic Acid
D015245:Deoxyribonuclease BamHI; D015246:Deoxyribonuclease EcoRI