Gene therapy for liver tumors.
Therapeutic gene transfer has progressed quite rapidly in recent years. Noticeably, it has now reached the clinical stage in both fields of inherited and acquired diseases. Numerous studies of liver-targeted gene therapy and cancer gene therapy have supported the hope that such innovative approaches may be of help in the treatment of primary or secondary liver tumors. In this article, the main strategies of experimental, hepatic cancer gene therapy in the prospect of a clinical use are reviewed.
Panis
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Y
Service de Chirurgie Digestive, Hôpital Lariboisière, Paris, France.
Rad
A R
AR
Boyer
O
O
Houssin
D
D
Salzmann
J L
JL
Klatzmann
D
D
D000256:Adenoviridae / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000628:therapy; D005544:Forecasting; D018014:Gene Transfer Techniques; D030342:Genetic Diseases, Inborn / Q000628:therapy; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D009857:Oncogenes / Q000235:genetics; D012190:Retroviridae / Q000235:genetics