title: mRNA and cytoskeletal filaments.
abstract: The localization of some mRNAs to distinct intracellular regions is achieved through interactions of the mRNA with cytoskeletal filaments. RNA-cytoskeletal interactions exist that influence the transport, anchoring and translation of mRNA. Recent analysis of RNA movements in living cells suggests the formation of RNA granules and their active transport along microtubules. The anchoring and translation of mRNA may be mediated by interactions with orthogonal networks of F-actin and elongation factor 1alpha.
authors.affiliation: Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
authors.forename: G
authors.initials: G
authors.lastname: Bassell
authors.forename: R H
authors.initials: RH
authors.lastname: Singer
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism*; D001692:Biological Transport / Q000502:physiology; D003599:Cytoskeleton / Q000737:chemistry* / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger