[Modifying effects of goitrogens on the tumor development in the liver and lung of rats].
In order to investigate whether goitrogens and liver enzyme-inducers modify the tumorigenesis in the liver or lung, 6-week old male F344 rats were given single subcutaneous injection of DHPN, and starting one week later received water containing goitrogens, namely sulfadimethoxine (SDM), propylthiouracil (PTU) and potassium thiocyanate (KSCN), or an enzyme-inducer, phenobarbital (PB), for 19 weeks ad libitum. Although the number of GST-P positive foci in the liver was significantly increased in the PB group as compared to the control group, there were no significant fluctuations in the SDM, PTU and PB groups. With respect to the lung, it is suggested that SDM, KSCN and PB may enhance the lung tumorigenesis, since the multiplicities of hyperplasias of alveolar epithelia were increased in groups treated with these compounds.
Takegawa
K
K
Mitsumori
K
K
Onodera
H
H
Shimo
T
T
Takahashi
M
M
Yasuhara
K
K
Takahashi
M
M
D000818:Animals; D013956:Antithyroid Agents / Q000633:toxicity*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D009602:Nitrosamines / Q000633:toxicity; D010634:Phenobarbital / Q000633:toxicity; D011441:Propylthiouracil / Q000633:toxicity; D051381:Rats; D011916:Rats, Inbred F344; D013412:Sulfadimethoxine / Q000633:toxicity; D013861:Thiocyanates / Q000633:toxicity
D013956:Antithyroid Agents; D009602:Nitrosamines; D013861:Thiocyanates; D013412:Sulfadimethoxine; C012457:diisopropanolnitrosamine; D011441:Propylthiouracil; C009941:potassium thiocyanate; D010634:Phenobarbital