title: The prion folding problem.
abstract: Prion diseases are neurodegenerative disorders in which dramatic conformational change in the structure of the prion protein is the fundamental event. This structural transition involves the loss of substantial alpha-helical content and the acquisition of beta-sheet structure. A convergence of recent biological and structural studies argues that the mechanism underlying the prion diseases is truly unprecedented.
authors.affiliation: University of California, Box Number 450, San Francisco, CA-94143, USA.
authors.forename: P M
authors.initials: PM
authors.lastname: Harrison
authors.forename: P
authors.initials: P
authors.lastname: Bamborough
authors.forename: V
authors.initials: V
authors.lastname: Daggett
authors.forename: S B
authors.initials: SB
authors.lastname: Prusiner
authors.forename: F E
authors.initials: FE
authors.lastname: Cohen
mesh_terms: D001704:Biopolymers; D009682:Magnetic Resonance Spectroscopy; D011328:Prions / Q000737:chemistry*; D017510:Protein Folding; D017434:Protein Structure, Tertiary
chemical_list: D001704:Biopolymers; D011328:Prions