[The effect of alpha-adrenoblockaders on the lipid complex of the myocardium, liver and erythrocytes in dogs with pulmonary heart failure].
Fatty acid spectrum of phospholipids and free cholesterol level in the myocardium, liver and erythrocytes were studied in dogs with the experimental lung-heart insufficiency (LHI). The content of polyunsaturated fatty acids of phospholipids in erythrocytes from peripheric blood and in free cholesterol level (2-3 times) in myocardium, liver and erythrocytes of dogs under investigated conditions decreased. It is shown that pharmacotherapy with alpha-adrenoblockers (thropaphen and prasozin) has led to the normalization of disturbances of the erythrocytic lipid complex and had caused inhibition of peroxidase reactions in the myocardium and liver of the dogs with LHI.
Frantsuzova
S B
SB
Arshinnikova
L L
LL
Briuzhina
T S
TS
Kravchenko
E Ia
EIa
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D006321:Heart / Q000187:drug effects*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011224:Prazosin / Q000494:pharmacology* / Q000627:therapeutic use; D011660:Pulmonary Heart Disease / Q000188:drug therapy* / Q000378:metabolism; D014326:Tropanes / Q000494:pharmacology* / Q000627:therapeutic use
D000317:Adrenergic alpha-Antagonists; D005227:Fatty Acids; D014326:Tropanes; C009599:tropodifene; D011224:Prazosin