title: Mutational specificity of the syn 1,2-dihydrodiol 3,4-epoxide of 5-methylchrysene.
abstract: The mutational specificity of the syn dihydrodiol epoxide of 5-methylchrysene in the supF gene of the pSP189 vector was examined. Transversion mutations at GC pairs predominated with G --> T and G --> C changes accounting for 42 and 21% of total base change mutations. The types of mutations found reflect the previously determined chemical preference of this reactive species for reaction with deoxyguanosine residues in DNA.
authors.affiliation: Chemistry of Carcinogenesis Laboratory, NCI Frederick Cancer Research and Development Center, MD 21702-1201, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Page
authors.forename: J
authors.initials: J
authors.lastname: Pataki
authors.forename: R G
authors.initials: RG
authors.lastname: Harvey
authors.forename: A
authors.initials: A
authors.lastname: Dipple
mesh_terms: D001483:Base Sequence; D002273:Carcinogens / Q000633:toxicity*; D002911:Chrysenes / Q000633:toxicity*; D005822:Genetic Vectors / Q000187:drug effects* / Q000235:genetics; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed / Q000235:genetics*; D014162:Transfection
chemical_list: D002273:Carcinogens; D002911:Chrysenes; C037783:1,2-dihydroxy-epoxy-1,2,3,4-tetrahydro-5-methylchrysene