[New concepts of the mechanisms of immunopatholgies+ of Streptococcal etiology].
The paper summarizes the data on the role of immunoglobulin Fc-receptor proteins of group A streptococci as one of the leading agents of the pathogenicity that initiates severe poststreptococcal complications in the comprehensive immunological and morphological study of acute experimental glomerulonephritis. In addition to some pathogenic effects, evidence is presented for the capacity of IgG FcR-positive, rather than IgG FcR-negative, group A streptococci of inducing the synthesis of great quantities of anti-IgG which has been detected both in free circulation and as part of immune complexes. IgG FcR proteins induced the release of antiinflammatory cytokines (TNF-alpha in particular) and anti-IgG FcR proteins, concurrently with complement C, formed deposits in the structures of glomerules, resulting in destructive and degenerative changes. The morphological criteria for delayed hypersensitivity processes, which are typical of inflammatory reactions in immunopathologies are discussed in the paper. Immunomorphological and electron microscopic studies at early stages revealed signs of membrane-proliferative glomerulonephritis with a predominant response of podocytes and mesangial cells, which later progressed to developed fibrous, atrophic, glomerulonephritis. It should be stressed that IgG FcR proteins, such as A and G staphylococcal protein, group G streptococcal protein, unlike group A streptococcal protein with the similar function either failed to cause the described events or the latter occurred rarely or delayed. The findings provide evidence for the author's concept of the role of IgG Fc-receptors of group A streptococci in the development of complications of streptococcal etiology.
Burova
L A
LA
NII of Experimental Medicine RAMN, Saint-Petersburg.
Nagornev
V A
VA
Pigarevskii
P V
PV
Gladilina
M M
MM
Seliverstova
V S
VS
Totolian
A A
AA
D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D000907:Antibodies, Bacterial / Q000276:immunology*; D005921:Glomerulonephritis / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D007074:Immunoglobulin G / Q000276:immunology*; D007668:Kidney / Q000276:immunology / Q000648:ultrastructure; D011817:Rabbits; D017452:Receptors, IgG / Q000276:immunology*; D013290:Streptococcal Infections / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D013291:Streptococcus / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D017452:Receptors, IgG