[The methodological aspects of experimental modelling and of assessing the hereditary sequelae of the irradiation of one and both parents].
The paper summarises some methodological approaches which may be used in experimental modelling and study of hereditary radiation effects in mammals. These approaches are aimed to the elucidation of the possible specific character (aggravation) of radiation damage in the offspring determined by the participation of two exposed parents in conception. The main attention is drawn to the dependence of hereditary radiation effects yield on the stages of the cell cycle of the parent germ cells at the moment of exposure and to criteria of evaluation of radiation damage in the offspring during the ontogenetic development.
Nefedov
I Iu
IIu
Nefedova
I Iu
IIu
Palyga
G F
GF
D000818:Animals; D004195:Disease Models, Animal; D005220:Fathers; D005260:Female; D005718:Gametogenesis / Q000528:radiation effects; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011831:Radiation Genetics / Q000379:methods; D011833:Radiation Injuries, Experimental / Q000235:genetics*