[Nitric oxide and carbon monoxide--a new class of signal molecules].
Recent data concerning the physiological, biochemical and pathological aspects of NO and CO in the brain are reviewed. Among them: biosynthesis, regulation and localization of corresponding enzymes (NOS, GO-2) and also cGMP in discrete populations of neurons; interrelationship between glutamate, NMDA-receptors, NO and CO; the role of NO and CO in different physiological and pathological processes in the nervous system, etc. On the basis of data obtained during the last several years, a conception of NO and CO as a novel class of signal molecules operating as neuromediators and/or retrograde transsynaptic messengers is discussed.
Markov
Kh M
KhM
D000818:Animals; D001921:Brain / Q000502:physiology; D002248:Carbon Monoxide / Q000378:metabolism*; D006801:Humans; D009474:Neurons / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology; D009569:Nitric Oxide / Q000502:physiology*; D017981:Receptors, Neurotransmitter / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D018377:Neurotransmitter Agents; D017981:Receptors, Neurotransmitter; D009569:Nitric Oxide; D002248:Carbon Monoxide