title: Impaired cerebral autoregulation after mild brain injury.
abstract: BACKGROUND
  Severe head injury may impair cerebral autoregulation, which can increase the risk of secondary neuronal injury. The likelihood of impairment in autoregulation is assumed to be low with mild head injury. We report here the absence of cerebral autoregulation in a patient who suffered a concussion from an automobile accident 6 days earlier.
  
  
  METHODS
  The patient participated in a clinical study approved by the institutional human subjects review committee, investigating the dose-effect relationship of anesthetics on cerebral autoregulation. The patient was scheduled to undergo repair of a knee injury suffered during a motor vehicle accident, during which she had a concussion. The screening evaluation revealed no evidence of neurologic disease. The test was to be performed three times in each patient: baseline autoregulation measurements during stable fentanyl-nitrous oxide anesthesia, second and third measurements during low dose and high dose of the anesthetic to which the patient was assigned. Autoregulation was tested by increasing the mean systemic blood pressure from 80 mm Hg-100 mm Hg using a phenylephrine infusion while simultaneously recording flow velocity from a middle cerebral artery using transcranial Doppler ultrasonography.
  
  
  RESULTS
  Static autoregulation testing during baseline testing demonstrated complete absence of this homeostatic mechanism and the study was canceled. Repeated testing in the recovery unit after the patient awoke showed identical results.
  
  
  CONCLUSIONS
  Trivial mild head injury may result in loss of cerebral autoregulation. A clinical study of a larger series to document the incidence is warranted.
authors.affiliation: Department of Anesthesiology, Harborview Medical Center, Seattle, WA 98104-2499, USA.
authors.forename: S
authors.initials: S
authors.lastname: Strebel
authors.forename: A M
authors.initials: AM
authors.lastname: Lam
authors.forename: B F
authors.initials: BF
authors.lastname: Matta
authors.forename: D W
authors.initials: DW
authors.lastname: Newell
mesh_terms: D000328:Adult; D018685:Anesthetics, Inhalation / Q000494:pharmacology; D018686:Anesthetics, Intravenous / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology*; D001924:Brain Concussion / Q000503:physiopathology*; D005260:Female; D005283:Fentanyl / Q000494:pharmacology; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D007718:Knee Injuries / Q000601:surgery; D009609:Nitrous Oxide / Q000494:pharmacology; D012720:Severity of Illness Index
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D009609:Nitrous Oxide; D005283:Fentanyl