title: Is rheumatoid arthritis becoming a milder disease? Or are we starting second-line therapy in patients with milder disease?
abstract: The aim of the study was to see whether rheumatoid arthritis (RA) is becoming a milder disease. Information on the initial disease activity and patient function (modified Health Assessment Questionnaire-HAQ) was collected in all RA patients enrolled into studies of sulphasalazine since 1980 in two Glasgow teaching hospitals. Patients (352) were enrolled in trials in the decade 1980-1989, and were compared to 374 patients enrolled in 1990-1994. Patients recruited in the 1980s were significantly younger, but had a similar disease duration to the 1990s patients. The 1980s patients had more active disease as measured by erythrocyte sedimentation rate (61 vs 44, P < 0.0001) and C-reactive protein (40 vs 26, P < 0.0001), and significantly worse function (HAQ 2.3 vs 1.9, P < 0.001). The response to sulphasalazine was very similar in the two cohorts, in terms of the percentage of patients remaining on therapy for 6 months, and the percentage improvement in measures of disease activity. Patients with milder disease were enrolled into the more recent trials of sulphasalazine. This may be because RA is becoming a milder disease, but other possible explanations are discussed.
authors.affiliation: Royal Infirmary, Glasgow.
authors.forename: D R
authors.initials: DR
authors.lastname: Porter
authors.forename: H A
authors.initials: HA
authors.lastname: Capell
authors.forename: I
authors.initials: I
authors.lastname: McInnes
authors.forename: R
authors.initials: R
authors.lastname: Munro
authors.forename: R
authors.initials: R
authors.lastname: Madhok
authors.forename: J A
authors.initials: JA
authors.lastname: Hunter
authors.forename: E A
authors.initials: EA
authors.lastname: Thomson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000453:epidemiology* / Q000628:therapy*; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012606:Scotland / Q000453:epidemiology; D012737:Sex Factors; D011795:Surveys and Questionnaires