title: [The determination of the complementation groups for the cells of patients with xeroderma pigmentosum and the Cockayne syndrome found in Russia].
abstract: Complementation groups for xeroderma pigmentosum (XP) and Cockayne's syndrome (CS) cells have been first determined for patients encountered in the former Soviet Union. The determination was carried out using fusion of fibroblasts to be examined with those of already known complementation groups, and subsequently registering the level of DNA unscheduled synthesis (for XP cells) and RNA synthesis recovery (for CS cells) after UV-irradiation. The evidence of the complementation was normalization of these indexes. Cells of XP2SP and XP4SP patients are shown to fall under the XPC complementation group, whereas CS1SP cells are classified within the CSA complementation group.
authors.forename: N M
authors.initials: NM
authors.lastname: Pleskach
authors.forename: V M
authors.initials: VM
authors.lastname: Mikhel'son
authors.forename: A
authors.initials: A
authors.lastname: Raams
authors.forename: D
authors.initials: D
authors.lastname: Bootsma
mesh_terms: D002459:Cell Fusion / Q000235:genetics; D002478:Cells, Cultured; D003057:Cockayne Syndrome / Q000235:genetics* / Q000473:pathology; D004247:DNA / Q000096:biosynthesis / Q000528:radiation effects; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism / Q000528:radiation effects; D005816:Genetic Complementation Test / Q000379:methods*; D006801:Humans; D012313:RNA / Q000096:biosynthesis / Q000528:radiation effects; D012426:Russia; D012867:Skin / Q000166:cytology; D012871:Skin Diseases / Q000235:genetics* / Q000473:pathology; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum / Q000235:genetics* / Q000473:pathology
chemical_list: D012313:RNA; D004247:DNA