title: Dobutamine echocardiography and quantitative rest-redistribution 201Tl tomography in myocardial hibernation. Relation of contractile reserve to 201Tl uptake and comparative prediction of recovery of function.
abstract: BACKGROUND
  The purposes of this study were to evaluate the comparative accuracy of dobutamine echocardiography and quantitative rest-redistribution 201Tl tomography in the prediction of recovery of function after revascularization and to assess the relation of contractile reserve to thallium uptake.
  
  
  RESULTS
  Thirty-four patients with stable coronary disease and regional dysfunction underwent dobutamine echocardiography (2.5 up to 40 micrograms.kg-1.min-1) and rest-redistribution 201Tl tomography 1 day before revascularization. Resting echocardiography and scintigraphy were repeated at > or = 6 weeks. Before revascularization, resting 201Tl uptake was similar in segments demonstrating biphasic or sustained improvement and was higher than in those exhibiting no change or worsening function during dobutamine. After revascularization, 201Tl uptake increased only in segments that showed a biphasic response (from 66 +/- 12% to 78 +/- 13%; P < .05). Biphasic response had a sensitivity of 74% and specificity of 89% for prediction of recovery. The use of biphasic or sustained improvement responses increased the sensitivity to 86% with a decrease in specificity to 68%. Qualitative thallium assessment provided a high sensitivity (98%) but poor specificity (27%). Quantification of thallium uptake, however, improved its accuracy: a maximal uptake (at rest or redistribution) of > or = 60% yielded a 90% sensitivity and a 56% specificity.
  
  
  CONCLUSIONS
  In patients with myocardial hibernation, biphasic response during dobutamine is less sensitive but more specific for recovery of function, whereas indexes of 201Tl scintigraphy are in general more sensitive and less specific, the least accurate being a qualitative assessment of thallium uptake. The sensitivity and specificity of both methods, however, can be altered depending on the quantitative criteria of thallium uptake or combination of responses of the myocardium to dobutamine.
authors.affiliation: Department of Medicine, Baylor College of Medicine, Methodist Hospital Echocardiography, Houston, TX 77030, USA.
authors.forename: U
authors.initials: U
authors.lastname: Qureshi
authors.forename: S F
authors.initials: SF
authors.lastname: Nagueh
authors.forename: I
authors.initials: I
authors.lastname: Afridi
authors.forename: P
authors.initials: P
authors.lastname: Vaduganathan
authors.forename: A
authors.initials: A
authors.lastname: Blaustein
authors.forename: M S
authors.initials: MS
authors.lastname: Verani
authors.forename: W L
authors.initials: WL
authors.lastname: Winters
authors.forename: W A
authors.initials: WA
authors.lastname: Zoghbi
mesh_terms: D000368:Aged; D004280:Dobutamine; D004452:Echocardiography; D005544:Forecasting; D006801:Humans; D008875:Middle Aged; D009200:Myocardial Contraction; D017682:Myocardial Stunning / Q000175:diagnosis* / Q000503:physiopathology*; D012016:Reference Values; D012146:Rest; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D013794:Thallium Radioisotopes; D004280:Dobutamine