title: Dynamic and static scintigraphic evaluation of cerebral arteriovenous malformations to evaluate radiosurgical treatment.
abstract: The radiobiologic changes induced by cobalt-60 gamma irradiation in cerebral arteriovenous malformations (AVMs) is a torpid process. Complete obliteration may take 1 or 2 years or even longer. Neuroradiological modalities like magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) do not provide sufficient information to comprehend this process. Digital subtraction angiography represents an invasive method and is therefore most often performed when complete obliteration is expected. The purpose of this study was to investigate the value of blood pool scintigraphy and functional imaging, such as single photon emission computed tomography (SPECT), to gain more knowledge about the volumetric changes of AVMs treated by radiosurgery. Twenty consecutive candidates for Gamma Knife treatment were selected for comparative MRI/ MRA and scintigraphic studies. All lesions ranging from 0.6 to 18.6 cm3 could be identified on blood pool and SPECT images. Seven patients had repetitive examinations at 3-month intervals to compare the relative volumetric change of the lesion. In 5 cases, a marked decrease in blood pooling was noticed after 3 months, and in 2 patients no significant change was evident. In contrast, MRI/MRA scans done at the same time did not similarly indicate progressive obliteration changes. This preliminary result indicates that scintigraphic evaluation using the blood pool technique is a very sensitive method to describe the relative volumetric change of radiosurgically treated AVMs.
authors.affiliation: Department of Neurosurgery, Karl Franzens University School of Medicine, Graz, Austria.
authors.forename: K A
authors.initials: KA
authors.lastname: Leber
authors.forename: R
authors.initials: R
authors.lastname: Aigner
authors.forename: R
authors.initials: R
authors.lastname: Nicoletti
authors.forename: G F
authors.initials: GF
authors.lastname: Fueger
authors.forename: G
authors.initials: G
authors.lastname: Pendl
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D005720:Gamma Rays; D015637:Gated Blood-Pool Imaging; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000000981:diagnostic imaging / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery; D013667:Technetium; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D013667:Technetium