[AIDS-related eosinophilic folliculitis. Efficacy of high dose topical corticotherapy].
BACKGROUND
A chronic pruriginous eruption of eosinophil-rich follicular papules and pustules is observed in AIDS patients. The pathogenesis of this disease, termed eosinophil folliculitis, is poorly understood and treatment is debated.


METHODS
A 30-year-old woman with AIDS developed highly pruriginous lesions of 5 month duration localized on the face, the trunk and upper limbs. There were papulo-pustules and excoriated papules. The elementary lesion was a follicular pustula. The eosinophil count was normal. The pathology examination revealed a rich eosinophil infiltration around the hair follicles and sebaceous glands as well as follicular spongiosis. Search for demodex, pityrosporons and a large number of infectious agents was negative. Oral minocyclin was uneffective. Local high-dose corticosteroids produced a remarkable effect and led to complete remission in 9 months.


CONCLUSIONS
Most cases of eosinophil folliculitis associated with AIDS have been reported in men, but rarely in Europe. The remarkable efficacy of the local corticosteroid in this case was exceptional. This condition could result from inappropriate inflammatory reaction in AIDS induced by various factors including demodex and pityrosporon. Several therapeutic approaches have been proposed to eradicate the triggering factors and others to modify the immune response. The exceptional response to the short local treatment with corticosteroids would suggest that this approach could be proposed as first intention treatment in eosinophil folliculitis associated with AIDS.
Grange
F
F
Service de Dermatologie, Hôpital Pasteur, Cedex.
Schoenlaub
P
P
Tortel
M C
MC
Peter
B
B
Audhuy
B
B
Guillaume
J C
JC
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000287:Administration, Topical; D000328:Adult; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001415:Back; D001623:Betamethasone / Q000008:administration & dosage; D002990:Clobetasol / Q000008:administration & dosage / Q000031:analogs & derivatives; D004359:Drug Therapy, Combination; D004802:Eosinophilia / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D005148:Facial Dermatoses / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D005260:Female; D005499:Folliculitis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D005938:Glucocorticoids; D006801:Humans; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D001623:Betamethasone; D002990:Clobetasol