title: Simultaneous bilateral thalamic hemorrhages following the administration of intravenous tissue plasminogen activator.
abstract: A patient suffered the onset of simultaneous bilateral thalamic hemorrhage several hours after the administration of intravenous tissue plasminogen activator. The patient exhibited features of the paramedian diencephalic syndrome, including executive dysfunction, anterograde amnesia, inattention, and disturbances of visual perception. During rehabilitation, she made significant gains in overlearned activities of daily living tasks, but her inability to retain new information left her severely disabled. The use of intravenous thrombolytic therapy is believed to account for this patient's unusual stroke syndrome. With recent evidence supporting the efficacy of intravenous thrombolysis in acute stroke, patients with multiple hemorrhagic strokes as a result of thrombolysis may become more common on rehabilitation services.
authors.affiliation: Stroke Rehabilitation Service, Division of Rehabilitation, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: A W
authors.initials: AW
authors.lastname: Dromerick
authors.forename: J F
authors.initials: JF
authors.lastname: Meschia
authors.forename: A
authors.initials: A
authors.lastname: Kumar
authors.forename: R E
authors.initials: RE
authors.lastname: Hanlon
mesh_terms: D000368:Aged; D000647:Amnesia / Q000139:chemically induced; D002543:Cerebral Hemorrhage / Q000139:chemically induced* / Q000503:physiopathology*; D003072:Cognition Disorders / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D009203:Myocardial Infarction / Q000188:drug therapy; D010960:Plasminogen Activators / Q000009:adverse effects*; D010959:Tissue Plasminogen Activator / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed
chemical_list: D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator