title: Persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking mGluR1.
abstract: Most of the cerebellar Purkinje cells (PCs) of an adult animal are innervated individually by a single climbing fiber (CF) that forms strong excitatory synapses with the PCs. This one-to-one relationship between a PC and a CF is a consequence of a developmentally regulated regression of the innervation of PCs by CFs. We found that, in mice deficient in the type 1 metabotropic glutamate receptor (mGluR1), the regression of supernumerary CFs ceases by the end of the second postnatal week, which is about one week earlier than in normal mice. Consequently, about one third of PCs in the mGluR1 mutant mice are innervated by multiple CFs in adulthood. We conclude that the regression of CFs normally occurs in two developmental phases and that mGluR1 plays a crucial role in the second phase.
authors.affiliation: Department of Physiology, Jichi Medical School, Minamikawachi-machi, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kano
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: H
authors.initials: H
authors.lastname: Kurihara
authors.forename: M
authors.initials: M
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Inoue
authors.forename: A
authors.initials: A
authors.lastname: Aiba
authors.forename: S
authors.initials: S
authors.lastname: Tonegawa
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002531:Cerebellum / Q000254:growth & development / Q000502:physiology*; D004594:Electrophysiology / Q000379:methods; D005071:Evoked Potentials; D066298:In Vitro Techniques; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D018345:Mice, Knockout; D008818:Mice, Neurologic Mutants; D009412:Nerve Fibers / Q000502:physiology*; D009473:Neuronal Plasticity; D011689:Purkinje Cells / Q000502:physiology*; D018094:Receptors, Metabotropic Glutamate / Q000187:drug effects* / Q000235:genetics; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission
chemical_list: D018094:Receptors, Metabotropic Glutamate; C104077:metabotropic glutamate receptor type 1