Proteases in Fas-mediated apoptosis.
Involvement of a unique family of cysteine proteases in the multistep apoptotic process has been documented. Cloning of several mammalian genes identifies some components of this cellular response. However, it is currently unclear which protease plays a role as a signal and/or effector of apoptosis. We summarize contributions to the data concerning proteases in Fas-mediated apoptosis.
Zhivotovsky
B
B
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Burgess
D H
DH
Schlegel
J
J
Pörn
M I
MI
Vanags
D
D
Orrenius
S
S
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002352:Carrier Proteins / Q000378:metabolism; D020170:Caspase 1; D053148:Caspase 3; D020169:Caspases; D003546:Cysteine Endopeptidases / Q000378:metabolism / Q000502:physiology*; D003593:Cytoplasm / Q000378:metabolism; D053200:Fas-Associated Death Domain Protein; D006801:Humans; D015513:Oncogene Proteins / Q000378:metabolism; D015398:Signal Transduction; D013379:Substrate Specificity; D014764:Viral Proteins / Q000378:metabolism; D019014:fas Receptor / Q000378:metabolism*
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; C505533:FADD protein, human; D053200:Fas-Associated Death Domain Protein; D015513:Oncogene Proteins; D014764:Viral Proteins; D019014:fas Receptor; C505407:CASP3 protein, human; D053148:Caspase 3; D020169:Caspases; D003546:Cysteine Endopeptidases; D020170:Caspase 1