title: Micellar electrokinetic chromatography as a fast screening method for the determination of the doping agents furosemide and piretanide in urine.
abstract: The possibility of using micellar electrokinetic chromatography for the screening of the loop diuretics piretanide and furosemide in urine was studied. A fast and simple method with good repeatability is described. The method was applied to urine samples collected from a healthy volunteer after oral administration of therapeutic doses of each compound. Positive identification in the urine matrix was possible through recording diode array spectra.
authors.affiliation: Department of Organic Chemistry, University of Ghent, Belgium.
authors.forename: S P
authors.initials: SP
authors.lastname: Lalljie
authors.forename: M B
authors.initials: MB
authors.lastname: Barroso
authors.forename: D
authors.initials: D
authors.lastname: Steenackers
authors.forename: R M
authors.initials: RM
authors.lastname: Alonso
authors.forename: R M
authors.initials: RM
authors.lastname: Jiménez
authors.forename: P
authors.initials: P
authors.lastname: Sandra
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D002940:Circadian Rhythm; D004232:Diuretics / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism / Q000652:urine*; D004300:Doping in Sports; D004563:Electrochemistry; D005665:Furosemide / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism / Q000652:urine*; D006801:Humans; D008823:Micelles; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet; D013449:Sulfonamides / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism / Q000652:urine*
chemical_list: D004232:Diuretics; D008823:Micelles; D013449:Sulfonamides; D005665:Furosemide; C015451:piretanide