title: [Pancreatic beta-cell hyperplasia in adults. A clinical case].
abstract: The author describe a rare case of pancreatic beta-cell hyperplasia. The patient was referred to us because of serious hypoglycemic crises. During hospitalization, endogenous hyperinsulinism was confirmed by hematochemical and instrumental tests. AngioCT of the pancreas evidenced a small lesion of the corpus, suspected of insulinoma. The patient underwent a corpus caudalis pancreatectomy: a small nodule with histologic neuroendocrine traits was ablated. A few days after the operation, new symptomatic hypoglycemia appeared. The hormonal tests confirmed a recurrence of endogenous hyperinsulinism. The patient underwent a new operation for pancreaticoduodenectomy: histological examination confirmed a pancreatic beta-cells hyperplasia. This condition has to be taken into account in the differential diagnosis of post prandial hypoglycemia. Besides, the observation of an insulinoma doesn't exclude the presence of a diffused disorder of islet cells as in the case above described.
authors.affiliation: Divisione di Endocrinologia e Malattie del Ricambio, Ospedale Mauriziano Umberto I, Torino .
authors.forename: C
authors.initials: C
authors.lastname: Rossi
authors.forename: A
authors.initials: A
authors.lastname: Grassi
authors.forename: B
authors.initials: B
authors.lastname: Torchio
authors.forename: N
authors.initials: N
authors.lastname: Ravarino
authors.forename: G
authors.initials: G
authors.lastname: Nasi
authors.forename: G
authors.initials: G
authors.lastname: Gallone
authors.forename: D
authors.initials: D
authors.lastname: Fonzo
mesh_terms: D002096:C-Peptide / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology* / Q000601:surgery; D006965:Hyperplasia; D007003:Hypoglycemia / Q000209:etiology* / Q000601:surgery; D007340:Insulinoma / Q000175:diagnosis; D007515:Islets of Langerhans / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000175:diagnosis; D016577:Pancreaticoduodenectomy
chemical_list: D002096:C-Peptide