title: Adoptive immunotherapy for Epstein-Barr virus-related lymphoma.
abstract: Epstein-Barr virus (EBV) causes opportunistic B cell lymphomas in patients whose cellular immunity is compromised. We have been investigating whether infusions of donor-derived, EBV-specific cytotoxic T cells can prevent and/or treat EBV-related lymphoproliferative disease in children receiving T cell-depleted bone marrow from HLA-matched, unrelated or HLA-mismatched, related donors. In this review, we discuss the rationale for this therapeutic approach, describe our experiences with the regimen thus far, and consider some future directions in immunotherapy.
authors.affiliation: Department of Hematology and Oncology, St. Jude Childrens' Research Hospital, Memphis, TN. 38105, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Smith
authors.forename: C Y
authors.initials: CY
authors.lastname: Ng
authors.forename: S K
authors.initials: SK
authors.lastname: Loftin
authors.forename: C
authors.initials: C
authors.lastname: Li
authors.forename: H E
authors.initials: HE
authors.lastname: Heslop
authors.forename: M K
authors.initials: MK
authors.lastname: Brenner
authors.forename: C M
authors.initials: CM
authors.lastname: Rooney
mesh_terms: D002648:Child; D006566:Herpesviridae Infections / Q000276:immunology* / Q000628:therapy*; D004854:Herpesvirus 4, Human; D006801:Humans; D007111:Immunity, Cellular; D016867:Immunocompromised Host; D016219:Immunotherapy, Adoptive; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000628:therapy* / Q000821:virology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014412:Tumor Virus Infections / Q000276:immunology* / Q000628:therapy*