title: Fibrinogen-like substance and thrombin-like enzyme in seminal plasma: coagulation system of human semen.
abstract: This investigation was conducted to examine the presence of fibrinogen-like substance and thrombin-like enzyme in human semen (human seminal plasma) after liquefaction. The human seminal plasma contained small amounts of respective substances which are absorbed on anti-fibrinogen and anti-thrombin III affinity columns, respectively. The thrombin-like enzyme with Gly-Pro-Arg-pNA amidolytic activity was inhibited by human seminal plasma trypsin-like enzyme inhibitor (HSP-TI) and antithrombin III. The fibrinogen-like substance reacted with the thrombin-like enzyme, forming a fibrin-like substance. It would appear that certain aspects of the coagulation process in human semen constitute the same process as the final stage of the blood coagulation system.
authors.affiliation: Department of Obstetrics and Gynecology, Eulji General Hospital, Chung-Ku, Seoul, Korea.
authors.forename: J Y
authors.initials: JY
authors.lastname: Park
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshimura
authors.forename: S
authors.initials: S
authors.lastname: Nozawa
authors.forename: T
authors.initials: T
authors.lastname: Umeda
authors.forename: S
authors.initials: S
authors.lastname: Akihama
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuda
mesh_terms: D000990:Antithrombin III / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005337:Fibrin / Q000378:metabolism; D005340:Fibrinogen / Q000737:chemistry; D006801:Humans; D008297:Male; D029584:Prostatic Secretory Proteins; D011506:Proteins / Q000032:analysis* / Q000737:chemistry / Q000502:physiology; D012661:Semen / Q000737:chemistry* / Q000201:enzymology / Q000502:physiology; D029589:Seminal Plasma Proteins; D013917:Thrombin / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D029584:Prostatic Secretory Proteins; D011506:Proteins; D029589:Seminal Plasma Proteins; C043076:beta-microseminoprotein; D000990:Antithrombin III; D005337:Fibrin; D005340:Fibrinogen; D013917:Thrombin