Age-related changes in nociception, behavior, and monoamine levels in rats.
1. Pain threshold, behavioral parameters, and monoamine levels were compared in two groups of rats: adult (12 months old) and old rats (25 months old). 2. No differences in nociception were found between the two groups using the tail-shock test. 3. Behavioral experiments with the holeboard test showed that locomotor activity and exploration activity were lower in aged animals, whereas no significant differences were found in emotivity. 4. Using high-performance liquid chromatography (HPLC) techniques, we found that serotonin and dopamine showed lower levels in the old group.
Goicoechea
C
C
Department of Pharmacology, School of Medicine, Universidad Complutense De Madrid, Spain.
Ormazábal
M J
MJ
Alfaro
M J
MJ
Martín
M I
MI
D000375:Aging / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D002851:Chromatography, High Pressure Liquid; D004298:Dopamine / Q000097:blood* / Q000378:metabolism; D008297:Male; D010147:Pain Measurement; D017288:Pain Threshold / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000097:blood* / Q000378:metabolism
D012701:Serotonin; D004298:Dopamine