Not just another Fab: the crystal structure of a TcR-MHC-peptide complex.
The structure of a ternary complex formed between a T-cell receptor, a major histocompatibility complex (MHC) protein and a viral peptide provides new insights into the cellular immune response. The results provide a molecular basis for understanding the development of T cells and the reactions leading to transplant rejection and autoimmunity.
Jardetzky
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Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA. jardetz@tochtli. biochem.nwu.edu
D016356:Gene Products, tax / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D015789:HLA-A2 Antigen / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D046911:Macromolecular Substances; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D013379:Substrate Specificity
D016356:Gene Products, tax; D015789:HLA-A2 Antigen; D046911:Macromolecular Substances; D016693:Receptors, Antigen, T-Cell, alpha-beta