title: The nature of thrombosis induced by platinum and tungsten coils in saccular aneurysms.
abstract: OBJECTIVE
  To compare the efficacy and biocompatability of electrolytic and mechanically detachable embolization coils of two metal types.
  
  
  METHODS
  Experimental saccular aneurysms in pigs were used to assess embolization induced by platinum or tungsten coils. Longitudinal angiographic and histologic studies were performed on treated and untreated (control) aneurysms to compare thrombosis and cellular responses after embolization with electrolytically detachable platinum coils and with mechanically detached tungsten coils.
  
  
  RESULTS
  Fewer tungsten than platinum coils were needed to induce thrombosis. The inflammatory response within the aneurysmal lumen was more florid in embolized aneurysms than in control aneurysms. No difference was found in the timing or extent of accumulation of eosinophils, lymphocytes, or polymorphs between the two coils used. Giant cell responses were more marked in treated aneurysms; tungsten coils more than platinum coils. The amount of collagen and fibrosis present increased over the study period and was similar in treated and control aneurysms.
  
  
  CONCLUSIONS
  The coil type influenced the initial cellular response but had little effect on the rate or degree to which blood clot within the aneurysm was replaced by fibrous tissue.
authors.affiliation: Department of Neuroradiology, Radcliffe Infirmary, Oxford, England.
authors.forename: J V
authors.initials: JV
authors.lastname: Byrne
authors.forename: J K
authors.initials: JK
authors.lastname: Hope
authors.forename: N
authors.initials: N
authors.lastname: Hubbard
authors.forename: J H
authors.initials: JH
authors.lastname: Morris
mesh_terms: D000818:Animals; D002536:Cerebral Arteries / Q000473:pathology; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D005260:Female; D005549:Foreign-Body Reaction / Q000473:pathology; D002532:Intracranial Aneurysm / Q000473:pathology / Q000628:therapy*; D008422:Materials Testing; D010984:Platinum; D013552:Swine; D014414:Tungsten
chemical_list: D010984:Platinum; D014414:Tungsten