title: Estrogen replacement therapy and exercise performance in postmenopausal women with coronary artery disease.
abstract: We treated 10 postmenopausal women with stable angina, positive exercise test, and documented coronary artery disease with oral conjugated equine estrogen (0.625 mg/day of Premarin) or placebo for 4 weeks, in random order, with crossover after a 4-week washout period. Exercise tests, performed after each treatment period while the patients were taking their usual antianginal drugs showed no differences; thus, short-term estrogen does not improve exercise-induced ischemia compared with placebo.
authors.affiliation: 2nd Department of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Sbarouni
authors.forename: Z S
authors.initials: ZS
authors.lastname: Kyriakides
authors.forename: N
authors.initials: N
authors.lastname: Nikolaou
authors.forename: D T
authors.initials: DT
authors.lastname: Kremastinos
mesh_terms: D000368:Aged; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology*; D018592:Cross-Over Studies; D045166:Estradiol Congeners / Q000494:pharmacology; D015914:Estrogen Replacement Therapy; D015444:Exercise / Q000502:physiology*; D005260:Female; D006321:Heart / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause
chemical_list: D045166:Estradiol Congeners