title: Avian models in developmental biology.
abstract: The avian embryo is uniquely amenable to experimental manipulation. The most widely used models are chimeras resulting from heterotopic or orthotopic exchanges of rudiments between chick and quail embryos, according to Le Douarin's technique (1969). Cell migrations and fates are traced in these chimeras either through the identification of quail cell nuclei stained for DNA or by means of monoclonal antibodies that recognize a particular lineage in only one of the two species. The ontogeny of the hemopoietic and endothelial lineages, as enlightened through appropriately designed chimeras, is reviewed in the present article. Homologies recently disclosed in mouse and human embryo are emphasized. Finally, the possibilities afforded by retroviral somatic transgenesis in the avian embryo will be envisaged.
authors.affiliation: Institut d'Embryologíe cellulaire et moléculaire du CNRS et du Collège de France.
authors.forename: F
authors.initials: F
authors.lastname: Dieterlen-Lièvre
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D001717:Birds / Q000196:embryology* / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002642:Chick Embryo / Q000166:cytology / Q000502:physiology*; D002678:Chimera; D003370:Coturnix / Q000196:embryology* / Q000502:physiology; D005822:Genetic Vectors; D006801:Humans; D007185:Incubators / Q000662:veterinary*; D008322:Mammals / Q000196:embryology* / Q000502:physiology; D051379:Mice; D008954:Models, Biological