title: Antibodies to epithelial components in oral lichen planus (OLP) associated with hepatitis C virus (HCV) infection.
abstract: Oral lichen planus (OLP) is a common chronic inflammatory disorder sometimes associated with hepatitis C virus (HCV) infection. An increased prevalence of autoimmune markers has been reported in patients with HCV infection. The aim of the present study was to determine, by conventional indirect immunofluorescence, the nature and frequency of circulating antibodies to epithelial antigens in the sera of HCV-positive patients who also have OLP. The study comprised four groups: 14 patients with OLP and HCV infection. 14 HCV-seronegative patients with OLP, 21 HCV-seropositive patients without OLP and 18 healthy controls. We found a significant association between the concomitance of OLP and HCV infection and the presence of such antibodies. It is concluded that some patients with HCV-associated OLP may have circulating antibodies to epithelial antigens, although their precise aetiological role in the development of this disease in HCV infection remains unknown.
authors.affiliation: Department of Oral Medicine, Eastman Dental Institute, London, UK.
authors.forename: G
authors.initials: G
authors.lastname: Lodi
authors.forename: I
authors.initials: I
authors.lastname: Olsen
authors.forename: A
authors.initials: A
authors.lastname: Piattelli
authors.forename: E
authors.initials: E
authors.lastname: D'Amico
authors.forename: L
authors.initials: L
authors.lastname: Artese
authors.forename: S R
authors.initials: SR
authors.lastname: Porter
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood; D004848:Epithelium / Q000276:immunology; D019084:Fluorescent Antibody Technique, Indirect; D006526:Hepatitis C / Q000150:complications* / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D017676:Lichen Planus, Oral / Q000150:complications* / Q000276:immunology*; D009061:Mouth Mucosa / Q000276:immunology
chemical_list: D000998:Antiviral Agents; D001323:Autoantibodies; D016898:Interferon-alpha