Partial seizures associated with cisplatin administration: a case report.
A 49-year-old man was treated with cisplatin and pirarubicin for tongue cancer. After the second course of chemotherapy, partial seizures including transient motor aphasia, tonic finger movement, and loss of consciousness were observed. The EEG showed frequent diffuse (multiple) spike and slow wave discharges. Following the administration of carbamazepine and diazepam, no seizures occurred and no paroxysmal discharges were observed or EEGs. We conclude that carbamazepine and diazepam administration was effective.
Fuse-Nagase
Y
Y
Department of Psychiatry, Aoyama Tokyo Metropolitan Officers' Hospital, Tokyo, Japan.
Suwa
K
K
Nagao
Y
Y
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives; D004569:Electroencephalography; D017029:Epilepsy, Complex Partial / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D014062:Tongue Neoplasms / Q000188:drug therapy
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin; C027260:pirarubicin; D002945:Cisplatin