Full-field electroretinograms in individuals with the Laurence-Mood-Bardet-Biedl syndrome.
OBJECTIVE
To evaluate rod and cone function in individuals with the Laurence-Moon-Bardet-Biedl syndrome.


METHODS
We obtained a full-field electroretinograms in 36 patients. If responses less than 10 microV were recorded with single white flashes a special techniques with narrow band filter and computer averaging was used.


RESULTS
No rod responses to dim blue light could be obtained in any of the patients. Residual cone flicker responses were measurable in 28 of the individuals. Those with amplitudes < 0.05 microV were significantly older than those with amplitudes > 1.00 microV. The ERG pattern was consistent within affected pairs of siblings in 8 families.


CONCLUSIONS
The retinal dystrophy in Laurence-Moon-Bardet-Biedl syndrome is primarily a rod-cone dystrophy, but even cone flicker amplitudes are severely reduced with further progression with age. There is no intrafamilial variability of the electroretinograms in affected siblings.
Riise
R
R
Department of Ophthalmology, Central Hospital of Hedmark, Hamar, Norway.
Andréasson
S
S
Tornqvist
K
K
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003623:Dark Adaptation / Q000502:physiology; D004596:Electroretinography; D005260:Female; D006801:Humans; D007849:Laurence-Moon Syndrome / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010786:Photoreceptor Cells / Q000502:physiology*; D012162:Retinal Degeneration / Q000235:genetics / Q000503:physiopathology*; D014792:Visual Acuity; D014794:Visual Fields