title: [Multifocal motor neuropathy with conduction block--a clinico-neuropathologic case report].
abstract: Descriptions on patients with multifocal motor neuropathy with conduction block (MMNCB), including histology, nerve fiber teasing and electron microscopy on nerve biopsy, are rare. We report a 64-year old female patient with progredient weakness of the upper extremities without sensory deficit. Electrophysiology shows conduction blocks up to 80% in several examined motor nerves. A biopsy of the sensory sural nerve reveals features of a mixed axonal and de- and remyelinating neuropathy. Thus sural nerve biopsy contributes here significantly to differential diagnosis and supports an immune mediated pathogenesis of MMNCB.
authors.affiliation: Klinischen Institut für Neurologie, Universität Wien.
authors.forename: S
authors.initials: S
authors.lastname: Urbanits
authors.forename: W
authors.initials: W
authors.lastname: Grisold
authors.forename: U
authors.initials: U
authors.lastname: Zifko
authors.forename: H
authors.initials: H
authors.lastname: Budka
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D001369:Axons / Q000473:pathology / Q000502:physiology; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D009046:Motor Neurons / Q000473:pathology / Q000502:physiology; D009186:Myelin Sheath / Q000473:pathology / Q000502:physiology; D009410:Nerve Degeneration / Q000502:physiology; D009412:Nerve Fibers / Q000473:pathology / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology; D009460:Neurologic Examination; D013497:Sural Nerve / Q000473:pathology / Q000503:physiopathology; D009435:Synaptic Transmission / Q000502:physiology*