Transcranial magnetic stimulation downregulates beta-adrenoreceptors in rat cortex.
Recently, a method for transcranial magnetic stimulation (TMS) of the brain has been developed. Thus, it is possible to explore neurochemical and behavioral effects of TMS in rats. Repeated TMS (9 days) reduced beta-adrenergic receptor binding in cortex, as does electroconvulsive shock (ECS) and other antidepressant treatments. Thus TMS appears to be a potential antidepressive treatment.
Fleischmann
A
A
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA.
Sternheim
A
A
Etgen
A M
AM
Li
C
C
Grisaru
N
N
Belmaker
R H
RH
D000318:Adrenergic beta-Agonists / Q000493:pharmacokinetics; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism / Q000528:radiation effects*; D015536:Down-Regulation / Q000528:radiation effects; D004574:Electromagnetic Fields; D006624:Hippocampus / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D008566:Membranes / Q000378:metabolism; D011412:Propanolamines / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D011943:Receptors, Adrenergic, beta / Q000528:radiation effects*
D000318:Adrenergic beta-Agonists; D011412:Propanolamines; D011943:Receptors, Adrenergic, beta; C033394:CGP 12177