title: [Effects of Gosha-Jinki-Gan on the function of the urinary bladder in anesthetized dogs].
abstract: Gosha-Jinki-Gan is clinically used for the treatment of pollakiuria in patients with benign prostatic hyperplasia. The effect of Gosha-Jinki-Gan on the function of the urinary bladder in anesthetized dogs was examined. Gosha-Jinki-Gan (100 mg/kg) inhibited the rhythmic bladder contractions (RBC). However, the frequency of RBC increased resembling the effect of atropine (0.1 mg/body), and the amplitude decreased. On the cystometrogram, Gosha-Jinki-Gan caused an increase in maximum vesical volume (not significant). These findings indicated that Gosha-Jinki-Gan is a useful drug for the treatment of pollakiuria.
authors.affiliation: Department of Urology, Gunma University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Kurokawa
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Higashi
authors.forename: C
authors.initials: C
authors.lastname: Ohma
authors.forename: K
authors.initials: K
authors.lastname: Imai
authors.forename: H
authors.initials: H
authors.lastname: Yamanaka
mesh_terms: D000758:Anesthesia; D000818:Animals; D003864:Depression, Chemical; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D012018:Reflex / Q000187:drug effects; D001743:Urinary Bladder / Q000187:drug effects* / Q000502:physiology; D014554:Urination / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal