[The influence of calcium channel blockers on antidepressant effects].
In C57BL/6 mice a combination of nifedipine (5 mg/kg) with imipramine (5 mg/kg), amitriptyline (5 mg/kg), pyrazidol (12.5 mg/kg), anafranil (6 mg/kg), and lithium chloride (25 mg/kg) diminished the immobilization time. The same was observed after treatment with a combination of phendiline (10 mg/kg) with amitriptyline, mianserin (3 mg/kg) and alpazolam (0.01 mg/kg). The inhibitory action of diazepam (0.5 mg/kg) in this test was prevented only by nifedipine. A depressogenic effect of alprazolam was enhanced by verapamil (10 mg/kg) and diminished by phendiline. It was concluded that nifedipine and phendiline has significant perspective in clinical trials.
Kozlovskiĭ
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VL
Prakh'e
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D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000627:therapeutic use; D003863:Depression / Q000209:etiology / Q000517:prevention & control; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D051379:Mice; D008810:Mice, Inbred C57BL; D012149:Restraint, Physical; D013623:Tail
D000928:Antidepressive Agents; D002121:Calcium Channel Blockers