Telomere crisis, the driving force in cancer cell evolution.
Cancer cells show characteristic telomere dynamics. Their chromosomes usually have short telomeres and a high telomerase activity. The "telomere crisis model" proposed here suggests that these unique telomeric features are responsible for the progression of cancer.
Ishikawa
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Department of Life Science, Tokyo Institute of Technology, Midori-ku, Yokohama, Japan.
D015139:Blotting, Southern; D002471:Cell Transformation, Neoplastic; D002877:Chromosomes, Human / Q000502:physiology / Q000648:ultrastructure; D004273:DNA, Neoplasm / Q000235:genetics; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D010677:Philadelphia Chromosome; D012091:Repetitive Sequences, Nucleic Acid; D019098:Telomerase / Q000378:metabolism*; D016615:Telomere / Q000473:pathology / Q000502:physiology*
D004273:DNA, Neoplasm; D019098:Telomerase