Characterization of pharmaceutical solvates by combined thermogravimetric and infrared analysis.
The combined physical analytical technique of thermogravimetric and infrared analysis (TG/IR) is described for the investigation of pharmaceutical solids. TG/IR provides an unequivocal identification of the volatile content of a pharmaceutical solid. In the case of pharmaceutical solvates, TG/IR provides identification of the evolved gas from the crystalline solid. Variable temperature X-ray diffraction and differential scanning calorimetry techniques provide the required information to ascertain whether the evolved gas was due to a solvent incorporated into the crystal lattice or physically adsorbed onto the solid. This work illustrates three examples of TG/IR as utilized in a multidisciplinary approach to the physical characterization of pharmaceutical solids.
Rodriguez
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Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, NJ 08903, USA.
Bugay
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DE
D002152:Calorimetry, Differential Scanning; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012997:Solvents; D013055:Spectrophotometry, Infrared / Q000379:methods*; D014961:X-Ray Diffraction
D004364:Pharmaceutical Preparations; D012997:Solvents