title: Intercalation of small hydrophobic molecules in lipid bilayers containing cholesterol.
abstract: Partitioning of small hydrophobic molecules into lipid bilayers containing cholesterol has been studied using the 2XC diffractometer at the University of Missouri Research Reactor. Locations of the compounds were determined by Fourier difference methods with data from both deuterated and undeuterated compounds introduced into the bilayers from the vapor phase. Data fitting procedures were developed for determining how well the compounds were localized. The compounds were found to be localized in a narrow region at the center of the hydrophobic layer, between the two halves of the bilayer. The structures are therefore intercalated structures with the long axis of the molecules in the plane of the bilayer.
authors.affiliation: Physics Department and Research Reactor, University of Missouri, Columbia 65211, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Worcester
authors.forename: K
authors.initials: K
authors.lastname: Hamacher
authors.forename: H
authors.initials: H
authors.lastname: Kaiser
authors.forename: R
authors.initials: R
authors.lastname: Kulasekere
authors.forename: J
authors.initials: J
authors.lastname: Torbet
mesh_terms: D002784:Cholesterol / Q000737:chemistry*; D003903:Deuterium; D005583:Fourier Analysis; D007364:Intercalating Agents; D016018:Least-Squares Analysis; D008051:Lipid Bilayers / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D010713:Phosphatidylcholines / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D007364:Intercalating Agents; D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D002784:Cholesterol; D003903:Deuterium