[Effects of Gosha-Jinki-Gan on the function of the urinary bladder in anesthetized dogs].
Gosha-Jinki-Gan is clinically used for the treatment of pollakiuria in patients with benign prostatic hyperplasia. The effect of Gosha-Jinki-Gan on the function of the urinary bladder in anesthetized dogs was examined. Gosha-Jinki-Gan (100 mg/kg) inhibited the rhythmic bladder contractions (RBC). However, the frequency of RBC increased resembling the effect of atropine (0.1 mg/body), and the amplitude decreased. On the cystometrogram, Gosha-Jinki-Gan caused an increase in maximum vesical volume (not significant). These findings indicated that Gosha-Jinki-Gan is a useful drug for the treatment of pollakiuria.
Suzuki
T
T
Department of Urology, Gunma University School of Medicine.
Kurokawa
K
K
Suzuki
K
K
Higashi
H
H
Ohma
C
C
Imai
K
K
Yamanaka
H
H
D000758:Anesthesia; D000818:Animals; D003864:Depression, Chemical; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D012018:Reflex / Q000187:drug effects; D001743:Urinary Bladder / Q000187:drug effects* / Q000502:physiology; D014554:Urination / Q000187:drug effects
D004365:Drugs, Chinese Herbal