title: Venlafaxine and metabolites are very weak inhibitors of human cytochrome P450-3A isoforms.
authors.affiliation: Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA.
authors.forename: L L
authors.initials: LL
authors.lastname: von Moltke
authors.forename: S X
authors.initials: SX
authors.lastname: Duan
authors.forename: D J
authors.initials: DJ
authors.lastname: Greenblatt
authors.forename: S M
authors.initials: SM
authors.lastname: Fogelman
authors.forename: J
authors.initials: J
authors.lastname: Schmider
authors.forename: J S
authors.initials: JS
authors.lastname: Harmatz
authors.forename: R I
authors.initials: RI
authors.lastname: Shader
mesh_terms: D000525:Alprazolam / Q000493:pharmacokinetics; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D001189:Aryl Hydrocarbon Hydroxylases; D001711:Biotransformation; D003511:Cyclohexanols / Q000494:pharmacology*; D051544:Cytochrome P-450 CYP3A; D065607:Cytochrome P-450 Enzyme Inhibitors; D004347:Drug Interactions; D018757:GABA Modulators / Q000493:pharmacokinetics; D006801:Humans; D066298:In Vitro Techniques; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D010089:Oxidoreductases, N-Demethylating / Q000037:antagonists & inhibitors*; D000069470:Venlafaxine Hydrochloride
chemical_list: D018687:Antidepressive Agents, Second-Generation; D003511:Cyclohexanols; D065607:Cytochrome P-450 Enzyme Inhibitors; D018757:GABA Modulators; D007527:Isoenzymes; D000069470:Venlafaxine Hydrochloride; D001189:Aryl Hydrocarbon Hydroxylases; D051544:Cytochrome P-450 CYP3A; D010089:Oxidoreductases, N-Demethylating; D000525:Alprazolam