Intravenous clofilium for conversion of atrial fibrillation.
Clofilium was administered to 14 patients with mainly chronic atrial fibrillation in a pilot study. QTc prolongation was observed, and 2 patients had conversion to sinus rhythm after drug infusion.
Borzak
S
S
Cardiovascular Division, Henry Ford Hospital, Detroit, Michigan 48202, USA.
Al-Khaled
N
N
Douthat
L
L
Steinberg
M
M
Goldberg
A D
AD
D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000503:physiopathology; D002908:Chronic Disease; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology / Q000627:therapeutic use*
D000889:Anti-Arrhythmia Agents; D000644:Quaternary Ammonium Compounds; C022799:clofilium