Tinnitus remission by lidocaine demonstrated by auditory-evoked magnetoencephalogram. A preliminary report.
An auditory-evoked magnetic field was recorded before and during tinnitus remission induced by an intravenous lidocaine injection. One and 4 kHz probe tones were presented monaurally in four tinnitus patients, and the responses were recorded using a 122-channel magnetometer. Three normal volunteers were also examined as controls. In tinnitus patients, the N100 m peak became sharper, while there was no marked change except for slight reduction in amplitude in normal subjects. Tinnitus remission by lidocaine may be related to attenuation of a masking-like effect of tinnitus on the sound-evoked responses.
Shiomi
Y
Y
Department of Hearing and Speech Science, Faculty of Medicine, Kyoto University, Japan.
Nagamine
T
T
Fujiki
N
N
Hirano
S
S
Naito
Y
Y
Shibasaki
H
H
Honjo
I
I
D000368:Aged; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D005072:Evoked Potentials, Auditory; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000627:therapeutic use*; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D014012:Tinnitus / Q000175:diagnosis* / Q000188:drug therapy*; D016896:Treatment Outcome
D000779:Anesthetics, Local; D008012:Lidocaine