title: Contrast-enhanced MR imaging in the evaluation of treatment response and prediction of outcome in multiple sclerosis.
abstract: MR imaging is becoming increasingly important in the evaluation of multiple sclerosis based on its sensitivity to acute, often subclinical events in the brain and because it provides a basis for measuring the accumulation of disease over time. Contrast-enhanced MR imaging in particular evaluates disease at the fundamental level of events affecting the blood-brain barrier. This review emphasizes (a) recent developments in the use of contrast-enhanced MR imaging as a measure of disease in patient groups and individuals and (b) its emerging role in evaluating new therapies.
authors.affiliation: Department of Radiology, University of Colorado Health Sciences Center, Denver 80262, USA.
authors.forename: J H
authors.initials: JH
authors.lastname: Simon
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000818:Animals; D002986:Clinical Trials as Topic; D003287:Contrast Media; D005069:Evaluation Studies as Topic; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D009900:Optic Nerve / Q000473:pathology; D011237:Predictive Value of Tests; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013116:Spinal Cord / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D003287:Contrast Media