title: [Effect of flubendazole on Muellerius capillaris in mouflon].
abstract: Muellerius capillaris is the most important pneumonematode of the mouflon kept in the Czech Republic. Particularly high values of prevalence and intensity of infection are recorded in the mouflon stocks kept in preserves. Numerous anthelmintics can be used for pharmacotherapy. Adulticide effect of the drug in verminous lung foci should be the aim of administrations. The aim of this study was to test anthelmintic efficacy of flubendazole (FBZ) against M. capiollaris in mouflon. The study was conducted in 16 mouflons in a small game preserve. An FBZ dose of 3 x 15 mg/kg live weight was chosen to be tested. Samples of mixed droppings were collected before treatment, during it and after its termination. LPG values were determined by larvoscopic examinations. Four (2 x 2) mouflons were shot on day 7 and 14 after treatment termination and they were subjected to detailed helminthologic examinations (macroscopic description of pulmonary verminous lesions, larvoscopy of verminous foci and mucus smears from the respiratory tract, larvoscopy of individual droppings). The game were extremely willing to ingest the drug applied with feed, the dosing schedule being confirmed. Pre-treatment LPG values of mixed droppings (Fig. 1) fell rapidly after the treatment started, and the excretion of M. capillaris larvae completely terminated beginning on day 7 after treatment termination. Pulmonary and coprological LPG findings in the shot mouflons (their description is in Tab. I) were minimum, in one animal only (Tab. II), in the others the findings were zero. Macroscopic findings (Fig. 2) showed that all shot mouflons had suffered from the infection to a large extent before treatment. The therapeutic efficacy of FBZ administered at a dose of 3 x 15 mg/kg of body weight can be in general evaluated highly positively. The drug administration quickly stopped larvae excretion in the mouflon droppings due to adulticide effect in the verminous foci of the lungs.
authors.affiliation: Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Lamka
authors.forename: M
authors.initials: M
authors.lastname: Vondrejc
authors.forename: J
authors.initials: J
authors.lastname: Klecá ková
mesh_terms: D000818:Animals; D000835:Animals, Wild / Q000469:parasitology*; D000969:Antinematodal Agents / Q000627:therapeutic use*; D018153:Czech Republic; D008463:Mebendazole / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008681:Metastrongyloidea / Q000187:drug effects*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*; D017206:Strongylida Infections / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000969:Antinematodal Agents; D008463:Mebendazole; C018945:flubendazole