title: [Clinical aspects of amyotrophic lateral sclerosis].
abstract: Amyotrophic lateral sclerosis is a progressive degenerative disease of upper and lower motor neurons with a prevalence of 4.3/100.000. The clinical symptoms include peripheral weakness and central spastic paresis and bulbar paralysis (weakness of mimic muscles, atrophy of the tongue, dysarthria). The prognosis leads to death within a few years. Pathogenetic factors are free O2-radicals, a disturbance of glutamate-metabolism, abnormal accumulation of neuronal proteins and autoimmunological mechanisms.
authors.affiliation: Universittsklinik für Neurologie, Wien.
authors.forename: J
authors.initials: J
authors.lastname: Zeitlhofer
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis* / Q000503:physiopathology; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000503:physiopathology; D010244:Bulbar Palsy, Progressive / Q000175:diagnosis / Q000503:physiopathology; D003937:Diagnosis, Differential; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D009046:Motor Neurons / Q000502:physiology; D009128:Muscle Spasticity / Q000175:diagnosis / Q000503:physiopathology; D009460:Neurologic Examination; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D018698:Glutamic Acid