Pulmonary mucormycosis in diabetic renal allograft recipients.
Renal allograft recipients are prone to opportunistic infections due to their need of immunosuppression to prevent rejection. Mucormycosis is a rare opportunistic infection caused by a fungi of the order Mucorales. Risk factors predisposing to this disease include prolonged neutropenia, chelation therapy for iron or aluminum overdose, diabetes, and patients who are immunosuppressed. Life-threatening infections can occur, as this fungi has the propensity to invade blood vessel endothelium, resulting in hematologic dissemination. Early diagnosis and prompt aggressive therapy is imperative to achieve an improved outcome. We present two cases of pulmonary mucormycosis in diabetic renal allograft recipients who were treated successfully with amphotericin B and surgical resection of the lesions with preservation of their allograft function. In this era of intensified immunosuppression, we may see an increased incidence of mucormycosis in our transplant population.
Latif
S
S
Department of Internal Medicine, St John Hospital and Medical Center, Detroit, MI 48236, USA.
Saffarian
N
N
Bellovich
K
K
Provenzano
R
R
D000328:Adult; D016866:Bacteroidaceae Infections / Q000175:diagnosis / Q000209:etiology; D003131:Combined Modality Therapy; D003928:Diabetic Nephropathies / Q000150:complications* / Q000601:surgery; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D009894:Opportunistic Infections / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D001443:Prevotella melaninogenica; D012233:Rhizopus; D014184:Transplantation, Homologous