title: A comment on interim analyses in crossover trials.
abstract: In a recent issue of Biometrics, Cook (1995, Biometrics, 51, 932-945) considered the possibility of applying sequential analysis to 2 x 2 crossover trials and made a comparison with more conventional approaches. We believe this comparison to be misleading in a number of respects.
authors.affiliation: Biometrics Department, Pfizer Central Research, Kent, United Kingdom.
authors.forename: A P
authors.initials: AP
authors.lastname: Grieve
authors.forename: S
authors.initials: S
authors.lastname: Senn
mesh_terms: D001699:Biometry / Q000379:methods*; D002986:Clinical Trials as Topic / Q000379:methods* / Q000706:statistics & numerical data; D018592:Cross-Over Studies; D003627:Data Interpretation, Statistical; D006801:Humans; D016013:Likelihood Functions