Cyclosporin A and multiple fibroadenomas of the breast.
Multiple bilateral fibroadenomas are uncommon. This finding in four women who had received renal transplants prompted further inquiry. A prospective study was performed on 39 women under the age of 55 years who had received a renal transplant at least 1 year earlier. Clinical examination and breast ultrasonography were performed. Factors considered included immunosuppressive therapy, concurrent medication and renal function. Blood was taken for estimation of oestradiol, prolactin, follicle-stimulating hormone (FSH) and sex hormone binding globulin levels. Fibroadenomas were found in 13 of 29 women who had received cyclosporin A: multiple in ten and bilateral in five. No abnormal breast findings were seen in 10 patients immunosuppressed with steroids and azathioprine alone (chi 2 = 7.30, 1 d.f., P < 0.01). Serum oestradiol concentration was raised in women with fibroadenomas compared with that in those with normal breasts (P < 0.05) and the level of FSH was lower (P < 0.01). Cyclosporin A may act on breast fibroblasts by humoral mechanisms and direct action.
Baildam
A D
AD
Department of Surgery, University Hospital of South Manchester, UK.
Higgins
R M
RM
Hurley
E
E
Furlong
A
A
Walls
J
J
Venning
M C
MC
Ackrill
P
P
Mansel
R E
RE
D000328:Adult; D001943:Breast Neoplasms / Q000139:chemically induced*; D002273:Carcinogens / Q000009:adverse effects*; D015331:Cohort Studies; D016572:Cyclosporine / Q000009:adverse effects*; D004958:Estradiol / Q000097:blood; D005260:Female; D018226:Fibroadenoma / Q000139:chemically induced*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008597:Menstrual Cycle; D008875:Middle Aged; D011388:Prolactin / Q000097:blood; D011446:Prospective Studies; D012738:Sex Hormone-Binding Globulin / Q000032:analysis
D002273:Carcinogens; D007166:Immunosuppressive Agents; D012738:Sex Hormone-Binding Globulin; D004958:Estradiol; D016572:Cyclosporine; D011388:Prolactin; D005640:Follicle Stimulating Hormone