title: Patterns of uterine activity. Using oxytocin after intracervical PGE2.
abstract: OBJECTIVE
  To compare patterns of uterine activity from low-dose oxytocin begun immediately or six hours after intracervical placement of prostaglandin E2 (PGE2) gel for the induction of labor.
  
  
  METHODS
  A total of 50 nonlaboring women at term with an unfavorable cervix (Bishop score < or = 4) were given a 0.5-mg dose of PGE2 gel. Each was then randomized either to be observed or to receive a low dose of oxytocin (2 mU/min, increased by 2 mU/min at 30-minute intervals, as necessary). After the six-hour observation, the patient was reexamined, and a low dose of oxytocin was either begun or continued. An adequate sample size (21 per group) was calculated for evaluating uterine activity changes. Comparisons were made using chi 2 testing, Student's t test and analysis of variance, as appropriate.
  
  
  RESULTS
  There were no differences between the two groups in maternal race, gestational age, predose Bishop score, predose uterine activity or indication for induction. Uterine contractions became more frequent (P < .01) and were judged to be more intense (P < .02) and earlier when oxytocin was used immediately after PGE2 placement. No uterine hyperstimulation or abnormal fetal heart rate pattern was observed that required discontinuation of the oxytocin. The percentages of cases delivering vaginally within 24, 36 and 48 hours were greater when oxytocin was begun immediately in nullipara (P < .01).
  
  
  CONCLUSIONS
  Low-dose oxytocin may be started immediately after instilling intracervical PGE2, with shortened time until the onset of adequate contractions.
authors.affiliation: Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA.
authors.forename: F H
authors.initials: FH
authors.lastname: Coleman
authors.forename: W F
authors.initials: WF
authors.lastname: Rayburn
authors.forename: L S
authors.initials: LS
authors.lastname: Burks
authors.forename: K C
authors.initials: KC
authors.lastname: Farmer
authors.forename: J D
authors.initials: JD
authors.lastname: Larson
authors.forename: G L
authors.initials: GL
authors.lastname: Turnbull
mesh_terms: D000282:Administration, Intravaginal; D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D015232:Dinoprostone / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D005260:Female; D005782:Gels; D006801:Humans; D007262:Infusions, Intravenous; D007751:Labor, Induced / Q000379:methods; D010120:Oxytocics / Q000008:administration & dosage / Q000494:pharmacology*; D010121:Oxytocin / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third; D011446:Prospective Studies; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects* / Q000502:physiology
chemical_list: D005782:Gels; D010120:Oxytocics; D010121:Oxytocin; D015232:Dinoprostone