Molecular cytogenetics of t(12;21) (p13;q22).
The translocation t(12;21)(p13;q22) is a frequent nonrandom rearrangement of B-cell lineage childhood acute lymphoblastic leukemia (ALL) which fuses the TEL and AML1 genes, normally localized to 12p13 and 21q22, respectively. The crucial chimeric gene, TEL-AML1, is transcribed from the der(21) and encodes the 336 NH2 aminoacics of TEL fused to the majority of the AML1 protein. The t(12;21) is very often associated with loss of the normal, untranslocated TEL allele. These various aspects are presented here.
Bernard
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OA
U 301 de l'Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.
Romana
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SP
Poirel
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H
Berger
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R
D002051:Burkitt Lymphoma / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12; D002891:Chromosomes, Human, Pair 21; D006801:Humans; D008967:Molecular Biology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D014178:Translocation, Genetic