RAS gene mutations in Chinese leukaemia patients and members of a family with high incidence of leukaemia.
We investigated mutations of N-RAS and K-RAS by using polymerase chain reaction (PCR)-oligonucleotide hybridization techniques in 40 cases of Chinese leukaemia patients and 17 presently healthy members of a family with high incidence of acute myeloid leukaemia. The results showed only two patients carried the mutation in codon 12 of N-RAS. Strikingly, however, in both cases the malignancies involved lymphoid lineage. There was no hereditary RAS mutation in the members of the remarkable family.
He
L Z
LZ
Department of Haematological Medicine, King's College School of Medicine and Dentistry, London, UK.
Stephenson
J
J
He
G Y
GY
Mufti
G J
GJ
D000208:Acute Disease; D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D002681:China / Q000453:epidemiology; D003062:Codon / Q000235:genetics; D004252:DNA Mutational Analysis; D011905:Genes, ras; D006801:Humans; D015994:Incidence; D007951:Leukemia, Myeloid / Q000453:epidemiology / Q000235:genetics*; D009386:Neoplastic Syndromes, Hereditary / Q000453:epidemiology / Q000235:genetics*; D016133:Polymerase Chain Reaction
D003062:Codon