Facilitation of retinal function recovery by coumarin derivatives.
Ischemic retinopathy is a difficult disease to treat, although numerous drugs have been tried in the clinics. Coumarin was one of those tried as an anti-coagulant with a marginal efficacy. In this study, 15 coumarin derivatives were studied on the b-wave recovery in electroretinogram which is an indicator of the functional recovery of retina after ischemic insult. It was found that when positions 6, 7 and 8 were occupied by various functional groups, the b-wave recovery could be markedly enhanced. On the other hand, single occupation of position 3 with any functional group would cause damaging effects to the anti-ischemic activity. It is concluded that some coumarin derivatives with two or all of these positions at 6, 7 and 8 occupied by certain functional groups could result in useful drugs for the treatment of ischemic retinopathy.
Liu
S X
SX
Institute of Ocular Pharmacology, Texas A&M University College of Medicine, College Station, USA.
Kapingu
M C
MC
Wang
M S
MS
Chiou
G C
GC
D000818:Animals; D000925:Anticoagulants / Q000737:chemistry / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D003623:Dark Adaptation; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D004596:Electroretinography; D005260:Female; D007511:Ischemia / Q000188:drug therapy / Q000503:physiopathology; D051381:Rats; D012160:Retina / Q000187:drug effects* / Q000502:physiology; D015356:Retinal Artery Occlusion / Q000188:drug therapy / Q000503:physiopathology; D013329:Structure-Activity Relationship
D000925:Anticoagulants; D003374:Coumarins; D004365:Drugs, Chinese Herbal; C030123:coumarin