Importance of cholinolytic drug selection for the efficacy of HI-6 against soman in rats.
The influence of cholinolytic drugs (atropine, benactyzine, biperiden) on the efficacy of the oxime HI-6 (1-[[[(4-aminocarbonyl)pyridinio]methoxy ]methyl]-2-[hydroxyimino)methyl]pyridinium dichloride monohydrate) on soman-induced anticholinesterase and stressogenic effects was studied in rats. Soman-induced acetylcholinesterase inhibition in blood and diaphragm and the stressogenic effects of soman, i.e. an increase in plasma corticosterone level and liver tyrosine aminotransferase activity, were more significantly diminished by HI-6 in combination with benactyzine or biperiden in comparison with HI-6 plus atropine. These findings support a hypothesis that benactyzine as well as biperiden can increase the efficacy of the oxime HI-6 in comparison with atropine. They demonstrate the importance of cholinolytic drug selection in the treatment of soman poisoning in rats. Ltd.
Kassa
J
J
Purkyne Military Medical Academy, Hradec Králové, Czech Republic.
D000110:Acetylcholinesterase / Q000097:blood / Q000378:metabolism; D000818:Animals; D000931:Antidotes / Q000494:pharmacology*; D001285:Atropine / Q000494:pharmacology; D001535:Benactyzine / Q000494:pharmacology; D001712:Biperiden / Q000494:pharmacology; D001921:Brain / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology / Q000633:toxicity*; D002801:Cholinesterase Reactivators / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood; D003964:Diaphragm / Q000201:enzymology; D004347:Drug Interactions; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D010091:Oximes; D011726:Pyridinium Compounds / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012999:Soman / Q000633:toxicity*; D013312:Stress, Physiological / Q000139:chemically induced; D014444:Tyrosine Transaminase / Q000378:metabolism
D000931:Antidotes; D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D010091:Oximes; D011726:Pyridinium Compounds; D001712:Biperiden; D001535:Benactyzine; D001285:Atropine; D012999:Soman; D014444:Tyrosine Transaminase; D000110:Acetylcholinesterase; C022870:asoxime chloride; D003345:Corticosterone