Influences of ovariectomy and continuous replacement of 17beta-estradiol on the tail skin temperature and behavior in the forced swimming test in rats.
The effect of ovariectomy and continuous subcutaneous replacement of 17beta-estradiol was examined in female Wistar rats. Tail skin temperature significantly increased in ovariectomized rats 6 days after ovariectomy, and the elevated level was sustained until 21 days after ovariectomy. 17beta-Estradiol at doses of 0.3 and 1.0 microg/body/day suppressed the increases in tail skin temperature. In the forced swimming test, the ovariectomized control rats showed significantly prolonged immobility time in comparison with sham-ovariectomized rats 14 days after ovariectomy. The duration of immobility of ovariectomized rats treated with 17beta-estradiol (0.3, 1.0, 3.0 microg/body/day) or maprotiline (0.6 mg/body/day) was significantly shorter than that of ovariectomized control rats.
Okada
M
M
Pharmaceutical Division, Ciba-Geigy Japan Limited, Takarazuka, Hyogo, Japan.
Hayashi
N
N
Kometani
M
M
Nakao
K
K
Inukai
T
T
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology* / Q000627:therapeutic use; D015914:Estrogen Replacement Therapy; D005260:Female; D008376:Maprotiline / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D012881:Skin Temperature / Q000187:drug effects*; D013623:Tail / Q000187:drug effects* / Q000502:physiology
D000929:Antidepressive Agents, Tricyclic; D008376:Maprotiline; D004958:Estradiol