Inhibition of 3,3',4,4',5-pentachlorobiphenyl-induced chicken embryotoxicity by 2,2',4,4',5,5'-hexachlorobiphenyl.
3,3',4,4',5-Pentachlorobiphenyl (pentaCB) caused a dose-dependent induction of chicken embryolethality, malformations, edema, and liver lesions at doses ranging from 0.5 to 12.0 microg/kg. In contrast, no embryotoxicity was observed after treatment with 10, 25, or 50 mg/kg 2,2',4,4',5,5'-hexaCB. In eggs cotreated with 2.0 microg/kg, 3,3',4,4',5-pentaCB plus 10, 25, or 50 mg/kg 2,2',4,4',5,5'-hexaCB, there was significant protection from 3,3',4,4',5-pentaCB-induced embryo malformations, edema, and liver lesions, whereas no inhibition of embryolethality was observed. These results further extend the response-specific nonadditive interactions of binary mixtures of polychlorinated biphenyls (PCBs) and should be considered in the development of approaches for hazard assessment of PCB mixtures and related compounds.
Zhao
F
F
Department of Veterinary Anatomy and Public Health, Texas A&M University, College Station 77843-4458, USA.
Mayura
K
K
Kocurek
N
N
Edwards
J F
JF
Kubena
L F
LF
Safe
S H
SH
Phillips
T D
TD
D000014:Abnormalities, Drug-Induced / Q000517:prevention & control*; D000818:Animals; D001502:Beak / Q000002:abnormalities*; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004625:Embryo, Nonmammalian / Q000002:abnormalities / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005124:Eye Abnormalities / Q000139:chemically induced / Q000517:prevention & control*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D011078:Polychlorinated Biphenyls / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D014921:Wings, Animal / Q000002:abnormalities*
D011078:Polychlorinated Biphenyls; C023035:3,4,5,3',4'-pentachlorobiphenyl; C014024:2,4,5,2',4',5'-hexachlorobiphenyl