Role of Bordetella bronchiseptica sialic acid-binding hemagglutinin as a putative colonization factor.
The role of Bordetella bronchiseptica sialic acid-binding hemagglutinin (SBHA) in bacterial colonization was studied by testing the ability of a phase-I strain carrying SBHA and its spontaneous mutants deficient in SBHA to colonize mouse tracheae. The mutants exhibited a remarkable reduction in colonizing ability, approximately 1,000-fold, when compared with that of the parent strain, suggesting that the possession of SBHA and the effective colonization by B. bronchiseptica organisms are closely related.
Ishikawa
H
H
National Institute of Animal Health, Ibaraki, Japan.
Sato
W
W
D000818:Animals; D001884:Bordetella / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D006388:Hemagglutinins / Q000235:genetics / Q000502:physiology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009154:Mutation; D013045:Species Specificity; D014132:Trachea / Q000382:microbiology*
D006388:Hemagglutinins