[Treatment and prognosis of juvenile parkinsonism--L-dopa responsiveness].
The treatment and prognosis of juvenile parkinsonism(JP) with onset under the age of 40 years is described. The patients with JP responded better to L-dopa and more gradual progression of symptoms, but, developed dopa-induced dyskinesias and motor fluctuations earlier and more frequently than Parkinson's disease patients. In order to control the dyskinesias and motor fluctuations, a small dose of L-dopa has to be administered several times a day with the combination of dopamine-receptor agonists. As a result of the increased life expectancy with L-dopa treatment the mean duration of the disease has increased in Parkinson's disease and JP, however, mean age at death in JP was still under 60.
Takubo
H
H
Department of Neurology, Juntendo University School of Medicine.
D000328:Adult; D017668:Age of Onset; D000978:Antiparkinson Agents / Q000008:administration & dosage* / Q000009:adverse effects; D018491:Dopamine Agonists / Q000008:administration & dosage; D004361:Drug Tolerance; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage* / Q000009:adverse effects; D010300:Parkinson Disease / Q000188:drug therapy*; D011379:Prognosis
D000978:Antiparkinson Agents; D018491:Dopamine Agonists; D007980:Levodopa