Enhancement of micronuclei frequency by vindesine in mouse bone marrow.
Treatment of mice with various doses (0, 0.25, 0.5, 1.0 and 2.0 mg/kg b.wt.) of vindesine resulted in a dose-dependent increase in the frequency of micronucleated polychromatic erythrocytes (MPCE) and micronucleated normochromatic erythrocytes. Conversely, the polychromatic erythrocyte and normochromatic erythrocyte (P/N ratio) ratio declined with increasing dose of vindesine. The dose effect relationship for MPCE, MNCE and P/N ratio was linear quadratic.
Jagetia
G C
GC
Department of Radiobiology, Kasturba Medical College, Manipal, India.
Jyothi
P
P
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009153:Mutagens; D014751:Vindesine / Q000633:toxicity*
D000972:Antineoplastic Agents, Phytogenic; D009153:Mutagens; D014751:Vindesine