Functions of fibroblast growth factors in vertebrate development.
Fibroblast growth factors (FGFs) are a class of secreted polypeptide ligands which mediate diverse cellular responses during embryonic, fetal, and postnatal vertebrate development. The purposes of this review are to provide a condensed overview of FGFs and their receptors, to catalog and categorize the functions of FGFs in vertebrate development, to present recent discoveries relating to the interplay of FGFs with other secreted ligands in the control of tissue growth and patterning, and to discuss several potential directions for future research in the field.
Goldfarb
M
M
Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA. mgoldfa@smtplink.mssm.edu
D000818:Animals; D017209:Apoptosis; D001842:Bone and Bones / Q000196:embryology; D002454:Cell Differentiation; D002455:Cell Division; D005121:Extremities / Q000196:embryology; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors / Q000502:physiology*; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D009024:Morphogenesis; D009420:Nervous System / Q000196:embryology; D011518:Proto-Oncogene Proteins / Q000502:physiology; D017468:Receptors, Fibroblast Growth Factor / Q000502:physiology*; D051153:Wnt Proteins; D029961:Zebrafish Proteins
C496456:FGF8 protein, human; D006133:Growth Substances; D011518:Proto-Oncogene Proteins; D017468:Receptors, Fibroblast Growth Factor; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors