Alkaline stress response in Enterococcus faecalis: adaptation, cross-protection, and changes in protein synthesis.
The alkaline shock response in Enterococcus faecalis was studied in this work. Cells adapted to an optimum pH of 10.5 were tolerate to pH 11.9 conditions but acquired sensitivity to acid damage. An analysis of stress proteins revealed that 37 polypeptides were amplified. Two of these are DnaK and GroEL. The combined results show that bile salts and alkaline stress responses are closely related.
Flahaut
S
S
Laboratoire de Microbiologie de l'Environnement, Université de Caen, France. lme@ibba.unicaen.fr
Hartke
A
A
Giard
J C
JC
Auffray
Y
Y
D000143:Acids / Q000494:pharmacology; D000220:Adaptation, Biological; D000468:Alkalies / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000096:biosynthesis*; D001647:Bile Acids and Salts / Q000494:pharmacology; D013293:Enterococcus faecalis / Q000187:drug effects / Q000502:physiology*; D006360:Heat-Shock Proteins / Q000096:biosynthesis*; D006863:Hydrogen-Ion Concentration
D000143:Acids; D000468:Alkalies; D001426:Bacterial Proteins; D001647:Bile Acids and Salts; D006360:Heat-Shock Proteins