Murine coronavirus infection: a paradigm for virus-induced demyelinating disease.
A variety of neurological diseases in humans, including multiple sclerosis (MS), have been postulated to have a viral etiology. The use of animal models provides insights into potential mechanism(s) involved in the disease process. The murine coronavirus-induced demyelinating disease in rodents is one such model for demyelinating disease in humans.
Lane
T E
TE
Dept of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037, USA.
Buchmeier
M J
MJ
D000818:Animals; D002908:Chronic Disease; D018352:Coronavirus Infections / Q000209:etiology* / Q000276:immunology*; D003711:Demyelinating Diseases / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008967:Molecular Biology / Q000379:methods; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000821:virology; D006517:Murine hepatitis virus / Q000276:immunology / Q000472:pathogenicity* / Q000502:physiology; D051381:Rats; D014777:Virus Diseases / Q000175:diagnosis / Q000235:genetics; D017735:Virus Latency