title: The acoustic properties of capsaicin-induced cough in healthy subjects.
abstract: Acoustic analysis of cough both in the time and frequency domain has been reported using voluntary and spontaneous cough. The main aim of this study was to discover whether such analysis of capsaicin-induced cough enables differences between normal subjects to be recognized. We present data from 13 healthy subjects (with normal lung function and no history of respiratory disease) using a new method of acoustic analysis, which presents the data in three graphical forms: 1) spectrogram; 2) overall spectral energy, 3) root mean square (RMS) pressure plots. Using the RMS sound pressure traces, different subjects had either two peaks, a single peak or multiple peaks. The occurrence of single and multiple peaks has previously been associated with disease states but we found them in normal subjects. The number of peaks and the visual pattern of the spectrogram was reproducible within and specific to each individual over time. During a peal of coughs in a single expiration, the peak amplitude of successive coughs decreased as lung volume reduced. Despite similarities in the overall spectral energy between individuals, there were marked differences in the small visual details of the spectrograms. However, in an individual, these small details were remarkably constant both within and between days, and can be regarded as a "cough signature". This type of spectrographic analysis provides a new approach to the analysis both of normal and abnormal cough sounds, and has identified similarities and differences in capsaicin-induced cough in normal individuals. It has potential as a tool with which to study the pathophysiology of cough.
authors.affiliation: Aintree Chest Centre, Fazakerley Hospital, Liverpool, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Doherty
authors.forename: L J
authors.initials: LJ
authors.lastname: Wang
authors.forename: S
authors.initials: S
authors.lastname: Donague
authors.forename: M G
authors.initials: MG
authors.lastname: Pearson
authors.forename: P
authors.initials: P
authors.lastname: Downs
authors.forename: S A
authors.initials: SA
authors.lastname: Stoneman
authors.forename: J E
authors.initials: JE
authors.lastname: Earis
mesh_terms: D000162:Acoustics; D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D001985:Bronchial Provocation Tests; D002211:Capsaicin / Q000008:administration & dosage / Q000009:adverse effects*; D003371:Cough / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D007509:Irritants / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009330:Nebulizers and Vaporizers; D010364:Pattern Recognition, Visual; D015203:Reproducibility of Results; D012119:Respiration; D012815:Signal Processing, Computer-Assisted; D013018:Sound Spectrography; D014797:Vital Capacity / Q000502:physiology
chemical_list: D007509:Irritants; D002211:Capsaicin