title: [Use of enzyme substitutes in hypolactasia].
abstract: The paper presents the results of clinical and laboratory studies of lactrase, a drug containing lactase. This agent is recommended for splitting lactic sugar in subjects with appreciably decreased production of endogenous lactase (hypolactasia). Twenty-eight patients with this condition were examined. Manifest clinical symptoms of the condition were observed after loading with 50 g of lactose in all examinees. Addition of 250 mg of lactrase to lactose led to complete clinical compensation of the deficit of endogenous lactase in 75% examinees, and if 500 mg of lactrase was administered, hypolactasia was compensated in virtually all patients. A single intake of 50 g of lactose with lactrase causes a statistically reliable increase of glycemia in such patients. Moreover, a reliable effect of lactrase was observed when measuring galactose in the urine following the lactose test with 250 and 500 mg of lactrase. Our results indicate a high efficacy of lactrase in the treatment of patients with hypolactasia.
authors.affiliation: Department of Propaedeutics of Internal Diseases, University, Petrozavodsk.
authors.forename: L N
authors.initials: LN
authors.lastname: Valenkevich
authors.forename: O I
authors.initials: OI
authors.lastname: Iakhontova
authors.forename: M E
authors.initials: ME
authors.lastname: Shubina
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D006801:Humans; D043322:Lactase; D007785:Lactose / Q000172:deficiency*; D007787:Lactose Intolerance / Q000097:blood / Q000188:drug therapy*; D007789:Lactose Tolerance Test; D008875:Middle Aged; D001616:beta-Galactosidase / Q000627:therapeutic use*
chemical_list: D043322:Lactase; D001616:beta-Galactosidase; D007785:Lactose