title: Interleukin-12 suppresses immunoglobulin E production but enhances immunoglobulin G4 production by human peripheral blood mononuclear cells.
abstract: The effect of interleukin-12 (IL-12) on human immunoglobulin G4 (IgG4) and IgE production was examined with cells derived from filarial patients and European controls. IL-12 inhibited IgE release but enhanced IgG4 production in cultures of peripheral blood mononuclear cells stimulated with anti-CD2 plus IL-2. When purified T- and B-cell cocultures were examined, IL-12 again markedly enhanced IgG4, whereas IgE production was no longer inhibited.
authors.affiliation: Department of Parasitology, Faculty of Medicine, Leiden University, The Netherlands.
authors.forename: B A
authors.initials: BA
authors.lastname: de Boer
authors.forename: Y C
authors.initials: YC
authors.lastname: Kruize
authors.forename: P J
authors.initials: PJ
authors.lastname: Rotmans
authors.forename: M
authors.initials: M
authors.lastname: Yazdanbakhsh
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D005368:Filariasis / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007371:Interferon-gamma / Q000502:physiology; D018664:Interleukin-12 / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D051379:Mice; D011817:Rabbits
chemical_list: D007074:Immunoglobulin G; D018664:Interleukin-12; D007073:Immunoglobulin E; D007371:Interferon-gamma