title: Serum protein alterations in canine ehrlichiosis.
abstract: Serum protein electrophoresis was performed in 42 dogs with naturally occurring Ehrlichia canis infection and in 15 clinically healthy dogs (control dogs). The infected dogs were found to have a significant hypoalbuminaemia, hyperglobulinaemia and hypergammaglobulinaemia compared to the control dogs (P < 0.001). A polyclonal gammopathy was found in all but one of the infected dogs which presented a monoclonal gammopathy. alpha-1 globulin was lower while alpha-2 and beta-2 globulin concentrations were significantly higher in the infected dogs (P < 0.0001, P < 0.05 and P < 0.005, respectively). The infected dogs were divided into two subgroups according to haematological parameters, defined as pancytopenic (n = 13) and non-pancytopenic (n = 29). When compared, the pancytopenic group revealed significantly lower concentrations of total protein, total globulin and gammaglobulin (P < 0.01, P < 0.05 and P < 0.005 respectively). The lower concentrations of the gammaglobulins coupled with the pancytopenia suggest that the immune state of the pancytopenic E. canis infected dogs is more compromised, and therefore secondary infections should be expected more frequently in these dogs.
authors.affiliation: Small Animal, Internal Medicine Department, School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel. harrus@agri.huji.ac.il
authors.forename: S
authors.initials: S
authors.lastname: Harrus
authors.forename: T
authors.initials: T
authors.lastname: Waner
authors.forename: Y
authors.initials: Y
authors.lastname: Avidar
authors.forename: E
authors.initials: E
authors.lastname: Bogin
authors.forename: H
authors.initials: H
authors.lastname: Peh
authors.forename: H
authors.initials: H
authors.lastname: Bark
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000032:analysis / Q000378:metabolism*; D004283:Dog Diseases; D004285:Dogs; D016873:Ehrlichiosis / Q000097:blood / Q000662:veterinary*; D004587:Electrophoresis, Agar Gel; D012709:Serum Albumin / Q000032:analysis; D012712:Serum Globulins / Q000032:analysis
chemical_list: D001798:Blood Proteins; D012709:Serum Albumin; D012712:Serum Globulins