[Curative treatment with fluconazole in 5 cases of invasive candidiasis].
BACKGROUND
Amphotericin B is the treatment of choice for invasive and disseminated Candida sp. infections. Fluconazole is an antifungal drug with less toxicity. Because of its pharmacokinetic properties, fluconazole can be specially useful in the treatment of invasive candidiasis. Although it is useful in several forms of candidiasis, its efficacy in deep-seated candidal infections is not totally proved due to the lack of comparative studies with amphotericin. In order to contribute new data about the usefulness of fluconazole in the treatment of invasive candidiasis, we report 5 patients which cured with this antifungal drug.


METHODS
The clinical records of those patients with invasive candidiasis that cured with fluconazole were retrospectively reviewed.


RESULTS
Fluconazole was used in 2 patients after detecting toxicity to amphotericin. Fluconazole was used from the beginning in the other 3 patients. None of the patients were neutropenic. All the patients cured without recurrence.


CONCLUSIONS
In this series, the employment of fluconazole was a non-toxic and effective alternative to amphotericin B in nonneutropenic patients with invasive candidiasis.
Martínez-Marcos
F J
FJ
Departamento de Medicina Interna, Hospital Universitario Virgen del Rocío, Sevilla.
Jiménez-Mejías
M E
ME
Moreno-Maqueda
I
I
Caballero-Granado
J
J
Rodríguez-Hernández
M J
MJ
Pachón-Díaz
J
J
D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
D000935:Antifungal Agents; D015725:Fluconazole