title: [Royleanones in the roots of Salvia officinalis L. of domestic provenance and their antimicrobial activity].
abstract: The reported investigation of the constituents of the petroleum ether extract of the root of Salvia officinalis L. confirmed the presence of the following diterpene quinones: 12.hydroxy-8, 12-abietadiene-11, 14-dione (royleanone), 7 alpha, 12-dihydroxy-8.12-abistadiene-11-14-dione (horminone) and 7 alpha-acetoxy-12-hydroxy-8, 12-abietadiene-11,14-dione (7-O-acetylhorminone). The compounds were identified on the basic of the interpretation of results of spectral analysis. Isolated royleanones show antimicrobial activity against gram-positive bacteria (Staphylococcus aureus). A study of abietate diterpenoids in the root of Salvia officinalis L. of Slovak provenance has been performed for the first time.
authors.affiliation: Katedra farmakognógie a botaniky Farmaceutickaj fakulty Univerzity Komenského, Bratislava.
authors.forename: I
authors.initials: I
authors.lastname: Masterová
authors.forename: E
authors.initials: E
authors.lastname: Misíková
authors.forename: L
authors.initials: L
authors.lastname: Sirotková
authors.forename: S
authors.initials: S
authors.lastname: Vaverková
authors.forename: K
authors.initials: K
authors.lastname: Ubik
mesh_terms: D045784:Abietanes; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D018154:Slovakia; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: C103400:7-O-acetylhorminone; D045784:Abietanes; D000900:Anti-Bacterial Agents; D004224:Diterpenes; D010936:Plant Extracts; C103399:royleanone; C045490:horminone