title: [Studies on the synthesis of cholecystokinin A receptor antagonists. II. Synthesis and cholecystokinin A receptor inhibitory activities of sulfur-containing amide-carboxylic acid derivatives].
abstract: A number of sulfur-containing amide-carboxylic acid derivatives were synthesized and tested for cholecystokinin A (CCK-A) receptor inhibitory activity in order to study structure-activity relationships. Significant CCK-A receptor inhibitory activities were found in only two series, that is, sulfoxide-carboxylic acid derivatives (9) and sulfone-carboxylic acid derivatives (10). As the most preferred compound, 5-(3,4-dichlorophenylsulfonyl)-4-(N,N-dipentylcarbamoyl)pent anoic acid (10n) was selected.
authors.affiliation: Central Research Laboratories, Kissei Pharmaceutical Co. Ltd., Nagano, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ajisawa
authors.forename: M
authors.initials: M
authors.lastname: Kitazawa
authors.forename: Y
authors.initials: Y
authors.lastname: Nakano
authors.forename: A
authors.initials: A
authors.lastname: Tsubaki
authors.forename: M
authors.initials: M
authors.lastname: Ban
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Okazaki
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D043886:Receptor, Cholecystokinin A; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013440:Sulfides / Q000494:pharmacology*; D013450:Sulfones / Q000494:pharmacology*; D013454:Sulfoxides / Q000494:pharmacology*
chemical_list: D043886:Receptor, Cholecystokinin A; D011949:Receptors, Cholecystokinin; D013440:Sulfides; D013450:Sulfones; D013454:Sulfoxides