title: Mediastinal parathyroid adenoma detected by 99mTc-methoxyisobutylisonitrile: report of a case.
abstract: We report herein the case of a 30-year-old man in whom ectopic mediastinal parathyroid adenoma was detected by 99mTc-methoxyisobutylisonitrile scintigraphy (99mTc-MIBI). The patient presented with a history of recurrent renal stones and was diagnosed as having primary hyperparathyroidism due to elevated serum levels of calcium and intact parathyroid hormone (i-PTH) levels. On admission, his serum calcium value was 12.1 mg/dl and the i-PTH level was 137 pg/ml. Ultrasonography, computed tomography (CT), and 201TlCl-99mTcO4- subtraction scintigraphy (Tl-Tc) were performed but none of these imaging techniques was able to detect an enlarged parathyroid gland. Selective venous sampling revealed that the serum i-PTH level was highest at 422 pg/ml in the left brachiocephalic vein. Exploration of the neck also proved unsuccessful. Finally, we performed 99mTc-MIBI which revealed and delineated an enlarged parathyroid gland in the upper mediastinum. Tumor extirpation was subsequently performed through a left thoracotomy. Pathologically, the tumor was confirmed to be a parathyroid adenoma and the serum calcium and i-PTH levels returned to within the normal ranges postoperatively.
authors.affiliation: First Department of Surgery, Kurume University School of Medicine, Fukuoka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ipponsugi
authors.forename: S
authors.initials: S
authors.lastname: Takamori
authors.forename: K
authors.initials: K
authors.lastname: Suga
authors.forename: T
authors.initials: T
authors.lastname: Koga
authors.forename: A
authors.initials: A
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Sirouzu
authors.forename: M
authors.initials: M
authors.lastname: Ishibashi
authors.forename: J
authors.initials: J
authors.lastname: Watanabe
authors.forename: A
authors.initials: A
authors.lastname: Jimi
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging*; D000328:Adult; D002828:Choristoma / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging*; D010280:Parathyroid Glands; D011877:Radionuclide Imaging; D017256:Technetium Tc 99m Sestamibi
chemical_list: D017256:Technetium Tc 99m Sestamibi