Fungicidal activity of cecropin A.
Cecropin A (CA) fungicidal properties were explored. Nongerminated and germinated Aspergillus spp. and Fusarium spp. conidia were treated with CA. CA achieved complete lethality at < or = 25 microM (99 micrograms/ml) for germinating, but not nongerminating, conidia of Aspergillus spp. CA achieved total lethality for nongerminated and germinating conidia of Fusarium spp at 1.5 microM (6 micrograms/ml). MIC and minimal lethal concentration assays in buffered RPMI medium gave similar results.
DeLucca
A J
AJ
Southern Regional Research Center, U.S. Department of Agriculture, New Orleans, Louisiana 70124, USA.
Bland
J M
JM
Jacks
T J
TJ
Grimm
C
C
Cleveland
T E
TE
Walsh
T J
TJ
D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides; D001230:Aspergillus / Q000187:drug effects* / Q000502:physiology; D002784:Cholesterol / Q000737:chemistry; D004875:Ergosterol / Q000737:chemistry; D005670:Fusarium / Q000187:drug effects* / Q000502:physiology; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D013172:Spores, Fungal / Q000187:drug effects
D000935:Antifungal Agents; D023181:Antimicrobial Cationic Peptides; D010455:Peptides; C031161:cecropin A; D002784:Cholesterol; D004875:Ergosterol