title: Lactate and epinephrine during exercise in altitude natives.
abstract: We tested the hypothesis that the reported low blood lactate accumulation ([La]) during exercise in altitude-native humans is refractory to hypoxianormoxia transitions by investigating whether acute changes in inspired O2 fraction (FIo2) affect the [La] vs. power output (W) relationship or, alternatively, as reported for lowlanders, whether changes in [La] vs. W on changes in FIo2 are related to changes in blood epinephrine concentration ([Epi]). Altitude natives [n = 8, age 24 +/- 1 (SE) yr, body mass 62 +/- 3 kg, height 167 +/- 2 cm] in La Paz, Bolivia (3,600 m) performed incremental exercise with two legs and one leg in chronic hypoxia and acute normoxia (AN). Submaximal one- and two-leg O2 uptake (Vo2) vs. W relationships were not altered by FIo2. AN increased two-leg peak Vo2 by 10% and peak W by 7%. AN paradoxically decreased one-leg peak Vo2 by 7%, whereas peak W remained the same. The [La] vs. W relationships were similar to those reported in unacclimatized lowlanders. There was a shift to the right on AN, and maximum [La] was reduced by 7 and 8% for one- and two-leg exercises, respectively. [Epi] and [La] were tightly related (mean r = 0.81) independently of FIo2. Thus normoxia attenuated the increment in both [La] and [Epi] as a function of W, whereas the correlation between [La] and [Epi] was unaffected. These data suggest loose linkage of glycolysis to oxidative phosphorylation under influence from [Epi]. In conclusion, high-altitude natives appear to be not fundamentally different from lowlanders with regard to the effect of acute changes in FIo2 on [La] during exercise.
authors.affiliation: Département de Physiologie, Centre Médical Universitaire, Universität Bern, Switzerland.
authors.forename: B
authors.initials: B
authors.lastname: Kayser
authors.forename: R
authors.initials: R
authors.lastname: Favier
authors.forename: G
authors.initials: G
authors.lastname: Ferretti
authors.forename: D
authors.initials: D
authors.lastname: Desplanches
authors.forename: H
authors.initials: H
authors.lastname: Spielvogel
authors.forename: H
authors.initials: H
authors.lastname: Koubi
authors.forename: B
authors.initials: B
authors.lastname: Sempore
authors.forename: H
authors.initials: H
authors.lastname: Hoppeler
mesh_terms: D000328:Adult; D000531:Altitude; D004837:Epinephrine / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007773:Lactates / Q000378:metabolism*; D008297:Male
chemical_list: D007773:Lactates; D004837:Epinephrine