title: Breathlessness and exercise capacity in heart failure: the role of bronchial obstruction and responsiveness.
abstract: The cause of the breathlessness and reduced exercise capacity that occur in patients with chronic heart failure remains obscure. We examined the hypothesis that airway obstruction and bronchial hyper-responsiveness, which are recognised features of chronic heart failure, might contribute to the breathlessness and reduced exercise capacity in this condition. We studied 37 patients (7 female) with chronic heart failure, of mean age 61 years. Each patient underwent: (i) lung function testing with spirometry and expiratory flow volume loops. (ii) Measurement of bronchial responsiveness to methacholine. (iii) Symptom-limited treadmill exercise capacity using both incremental and fixed workload protocols, with measurement of Borg scores for breathlessness. Lung function was not significantly related to either exercise time, or Borg symptom scores in either exercise protocol. Bronchial hyper-responsiveness to methacholine was demonstrated in 12 patients. Exercise time did not correlate with the degree of bronchial hyper-responsiveness in these 12 patients. Group mean exercise time and Borg scores were not significantly different in these 12 patients when compared to the 25 patients in whom bronchial hyper-responsiveness was not found. We conclude that airway obstruction and bronchial hyper-responsiveness are not likely to be important determinants of reduced exercise capacity and breathlessness in chronic heart failure.
authors.affiliation: Respiratory Medicine, University Hospital, Nottingham, UK.
authors.forename: S A
authors.initials: SA
authors.lastname: Evans
authors.forename: W J
authors.initials: WJ
authors.lastname: Kinnear
authors.forename: L
authors.initials: L
authors.lastname: Watson
authors.forename: M
authors.initials: M
authors.lastname: Hawkins
authors.forename: A J
authors.initials: AJ
authors.lastname: Cowley
authors.forename: I D
authors.initials: ID
authors.lastname: Johnston
mesh_terms: D000402:Airway Obstruction / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D016084:Bronchoconstriction / Q000187:drug effects / Q000502:physiology*; D016085:Bronchoconstrictor Agents; D002908:Chronic Disease; D003937:Diagnosis, Differential; D004417:Dyspnea / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D005080:Exercise Test; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D006333:Heart Failure / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D008297:Male; D016210:Methacholine Chloride; D008875:Middle Aged; D012129:Respiratory Function Tests
chemical_list: D016085:Bronchoconstrictor Agents; D016210:Methacholine Chloride