Molecular cloning and chromosomal localization in human and mouse of the SH2-containing inositol phosphatase, INPP5D (SHIP). Amgen EST Program.
The action of lipid phosphatases on inositol phosphates is thought to be one method that the cell uses to attenuate growth factor- or cytokine-induced mobilization of calcium. We have cloned a cDNA from a mouse spleen library that is virtually identical to the recently described inositol tetraphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase, SHIP. Chromosomal localization studies in human and mouse by FISH mapping and interspecies backcrossing in mice have demonstrated that human SHIP is localized to 2q36-q37.1 and that mouse SHIP is localized to 1C5.
Liu
Q
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Amgen Institute, Toronto, Ontario, Canada.
Dumont
D J
DJ
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D003001:Cloning, Molecular; D003433:Crosses, Genetic; D004247:DNA; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D000072183:Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; D010744:Phosphoric Monoester Hydrolases / Q000737:chemistry / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D018909:src Homology Domains
D004247:DNA; D010744:Phosphoric Monoester Hydrolases; C098706:INPPL1 protein, human; D000072183:Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases