title: TJS-010, a new prescription of oriental medicine, enhances 8-OH-DPAT-induced effects in rats.
abstract: We evaluated the effect of TJS-010, a new prescription of oriental medicine, on hypothermia and flat body posture in rats, induced by activation of serotonin (5-HT)-1A receptors by (+/-)-8-hydroxy-2-(di-N-propylamino)-tetralin (8-OH-DPAT). Hypothermia was induced by 8-OH-DPAT in a dose and time-dependent manner. The hypothermia induced by 0.1 mg/kg 8-OH-DPAT was enhanced by 500 and 750 mg/kg of TJS-010. At the concentration of 0.1 mg/kg, 8-OH-DPAT also produced flat body posture in rats, and 750 mg/kg TJS-010 increased the flat body posture. These results suggest that TJS-010 facilitates the 5-HT-1A receptors in the central nervous system.
authors.affiliation: Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kagaya
authors.forename: A J
authors.initials: AJ
authors.lastname: Tanra
authors.forename: H
authors.initials: H
authors.lastname: Shinno
authors.forename: A
authors.initials: A
authors.lastname: Kugaya
authors.forename: M
authors.initials: M
authors.lastname: Muraoka
authors.forename: T
authors.initials: T
authors.lastname: Oyamada
authors.forename: Y
authors.initials: Y
authors.lastname: Uchitomi
authors.forename: S
authors.initials: S
authors.lastname: Yamawaki
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D011187:Posture / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
chemical_list: D014151:Anti-Anxiety Agents; D010936:Plant Extracts; D017366:Serotonin Receptor Agonists; C103811:TJS 010; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin