Amyloid fibrils. Mutations make enzyme polymerize.
Perutz
M F
MF
D000544:Alzheimer Disease / Q000473:pathology; D000682:Amyloid / Q000737:chemistry / Q000378:metabolism*; D000686:Amyloidosis / Q000235:genetics*; D001921:Brain / Q000473:pathology; D006801:Humans; D009113:Muramidase / Q000235:genetics* / Q000378:metabolism; D017354:Point Mutation; D017096:Prion Diseases / Q000473:pathology; D011328:Prions / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation
D000682:Amyloid; D011328:Prions; D009113:Muramidase