title: [Request for pathophysiologic explanation of hypoxemic disorders (e.g. heart defect with right-left shunt, diseases with respiratory insufficiency) leading to clubbed fingers and toes and hour-glass nail manifestations].
authors.affiliation: Medizinische Klinik und Poliklinik mit Schwerpunkt Kardiologie und Pulmologie, Universitätsklinikums Benjamin Franklin Freien Universität, Berlin.
authors.lastname: Horstkotte
mesh_terms: D005385:Fingers / Q000098:blood supply; D006330:Heart Defects, Congenital / Q000503:physiopathology*; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D008173:Lung Diseases, Obstructive / Q000503:physiopathology*; D008533:Megakaryocytes / Q000502:physiology; D009262:Nails / Q000098:blood supply; D009264:Nails, Malformed / Q000503:physiopathology*; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000503:physiopathology*; D010974:Platelet Aggregation / Q000502:physiology; D010982:Platelet-Derived Growth Factor / Q000502:physiology; D014034:Toes / Q000098:blood supply; D014655:Vascular Resistance / Q000502:physiology
chemical_list: D010982:Platelet-Derived Growth Factor