Effects of acute prenatal ethanol exposure on Bergmann glia cells early postnatal development.
The effects of acute ethanol exposure during the prenatal phase of Bergmann glia cell (Bgc) generation were evaluated in three postnatal days. Ethanol exposed rats showed Bgc with reduced soma size, decreased number and width of their fibers, and increased fiber length, when compared with control animals. These differences, however, were significant at postnatal day 12. Our results demonstrate that acute, prenatal exposure to ethanol during critical stages of brain development disrupts Bgc early postnatal development.
Pérez-Torrero
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E
Centro de Neurobiología, Universidad Nacional Autónoma de México, Ciudad Universitaria, México D.F..
Durán
P
P
Granados
L
L
Gutiérez-Ospina
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G
Cintra
L
L
Díaz-Cintra
S
S
D000818:Animals; D048429:Cell Size / Q000187:drug effects; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D002531:Cerebellum / Q000187:drug effects / Q000254:growth & development; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D009457:Neuroglia / Q000187:drug effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar
D002492:Central Nervous System Depressants; D000431:Ethanol