Reed-Sternberg cells and "bystander" lymphocytes in lymph nodes affected by Hodgkin's disease are infected with different strains of Epstein-Barr virus.
In most cases of Epstein-Barr virus (EBV)-associated Hodgkin's disease (HD), EBV-positive Reed-Sternberg (RS) cells and rare EBV-positive reservoir lymphocytes coexist in lymph nodes. Here we show that, in two cases of EBV-associated HD, strains infecting RS cells and reservoir lymphocytes of the same patient have different BNLF-1 genes. This suggests that RS cells and reservoir lymphocytes of the same patient are infected by different EBV strains.
Meggetto
F
F
Centre d'Immunopathologie et de Génétique Humaine, CNRS UPR8291, Toulouse, France.
Brousset
P
P
Selves
J
J
Delsol
G
G
Mariame
B
B
D000818:Animals; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006689:Hodgkin Disease / Q000821:virology*; D006801:Humans; D008198:Lymph Nodes / Q000821:virology; D008214:Lymphocytes / Q000821:virology; D051379:Mice; D016513:Mice, SCID