Mutational specificity of the syn 1,2-dihydrodiol 3,4-epoxide of 5-methylchrysene.
The mutational specificity of the syn dihydrodiol epoxide of 5-methylchrysene in the supF gene of the pSP189 vector was examined. Transversion mutations at GC pairs predominated with G --> T and G --> C changes accounting for 42 and 21% of total base change mutations. The types of mutations found reflect the previously determined chemical preference of this reactive species for reaction with deoxyguanosine residues in DNA.
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J E
JE
Chemistry of Carcinogenesis Laboratory, NCI Frederick Cancer Research and Development Center, MD 21702-1201, USA.
Pataki
J
J
Harvey
R G
RG
Dipple
A
A
D001483:Base Sequence; D002273:Carcinogens / Q000633:toxicity*; D002911:Chrysenes / Q000633:toxicity*; D005822:Genetic Vectors / Q000187:drug effects* / Q000235:genetics; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed / Q000235:genetics*; D014162:Transfection
D002273:Carcinogens; D002911:Chrysenes; C037783:1,2-dihydroxy-epoxy-1,2,3,4-tetrahydro-5-methylchrysene