title: Purpura caused by Emla is of toxic origin.
abstract: Emla cream has been widely used as a local anaesthetic for superficial procedures. Blanching and redness are commonly observed side-effects. We observed purpura in 5 patients after application of Emla. Other authors have not reported this before. In 4 patients, purpura was observed after 30 min Emla application before the treatment of mollusca contagiosa. In 1 patient, Emla was used for 60 min before taking a lip biopsy. In these patients, patch tests were performed with the individual ingredients of Emla cream, Emla cream itself, placebo cream, and Tegaderm plaster. All tests were negative at an early reading after 30 min as well as after 2 and 3 days. We concluded that the purpuric reaction was not of an allergic nature. Possibly, it was caused by a toxic effect on the capillary endothelium.
authors.affiliation: Department of Dermato-Venereology (Pediatric Dermatology Unit), University Hospital Rotterdam, The Netherlands.
authors.forename: F B
authors.initials: FB
authors.lastname: de Waard-van der Spek
authors.forename: A P
authors.initials: AP
authors.lastname: Oranje
mesh_terms: D000779:Anesthetics, Local / Q000009:adverse effects*; D001706:Biopsy; D002196:Capillaries / Q000187:drug effects; D003877:Dermatitis, Contact / Q000209:etiology; D004338:Drug Combinations; D004730:Endothelium, Vascular / Q000187:drug effects; D006801:Humans; D008012:Lidocaine / Q000009:adverse effects*; D000077442:Lidocaine, Prilocaine Drug Combination; D008046:Lip / Q000473:pathology; D008976:Molluscum Contagiosum / Q000601:surgery; D009779:Occlusive Dressings / Q000009:adverse effects; D009824:Ointments; D010328:Patch Tests; D010919:Placebos; D011318:Prilocaine / Q000009:adverse effects*; D011693:Purpura / Q000139:chemically induced*; D013997:Time Factors
chemical_list: D000779:Anesthetics, Local; D004338:Drug Combinations; D000077442:Lidocaine, Prilocaine Drug Combination; D009824:Ointments; D010919:Placebos; D011318:Prilocaine; D008012:Lidocaine