title: Reduced glutathione and S-acetylglutathione as selective apoptosis-inducing agents in cancer therapy.
abstract: The effect of reduced glutathione (GSH) and S-acetylglutathione (S-acglu) treatment on several tumor cell lines and normal cells in vitro was investigated. GSH and S-acglu applied at concentrations of 1 mM and 2 mM induced apoptosis in malignant cells as shown by DNA-fragmentation and staining of apoptotic cells with 7-amino-actinomycin D while viability and growth of normal cells were not significantly influenced by this treatment. The results demonstrated that GSH and S-acglu may be selective inducers of apoptosis in malignant cells.
authors.affiliation: Department of Biological Chemistry, University Medical Center, Franfurt am Main, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Donnerstag
authors.forename: G
authors.initials: G
authors.lastname: Ohlenschlager
authors.forename: J
authors.initials: J
authors.lastname: Cinatl
authors.forename: M
authors.initials: M
authors.lastname: Amrani
authors.forename: D
authors.initials: D
authors.lastname: Hofmann
authors.forename: S
authors.initials: S
authors.lastname: Flindt
authors.forename: G
authors.initials: G
authors.lastname: Treusch
authors.forename: L
authors.initials: L
authors.lastname: Träger
mesh_terms: D017209:Apoptosis; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D053938:DNA Fragmentation; D004273:DNA, Neoplasm / Q000032:analysis / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D004587:Electrophoresis, Agar Gel; D005978:Glutathione / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000473:pathology
chemical_list: D004273:DNA, Neoplasm; C096306:S-acetylglutathione; D005978:Glutathione