title: The effects of low-dose dopamine on splanchnic blood flow and oxygen uptake in patients with septic shock.
abstract: OBJECTIVE
  To assess the effects of low-dose dopamine on splanchnic blood flow and splanchnic oxygen uptake in patients with septic shock.
  
  
  METHODS
  Prospective, controlled trial.
  
  
  METHODS
  University hospital intensive care unit.
  
  
  METHODS
  11 patients with septic shock, diagnosed according the criteria of the 1992 American College of Chest Physicians/Society of Critical Care Medicine consensus conference, who required treatment with norepinephrine.
  
  
  RESULTS
  Systemic and splanchnic hemodynamics and oxygen transport were measured before and during addition of low-dose dopamine (3 micrograms/kg per min). Low-dose dopamine and a marked effect on total body hemodynamics and oxygen transport. The fractional splanchnic flow at baseline ranged from 0.15 to 0.57. In 7 patients with a fractional splanchnic flow less than 0.30, low-dose dopamine increased splanchnic flow and splanchnic oxygen delivery and oxygen consumption. In 4 patients with a fractional splanchnic flow above 0.30, low-dose dopamine did not appear to change splanchnic blood flow.
  
  
  CONCLUSIONS
  Low-dose dopamine has a potential beneficial effect on splanchnic blood flow and oxygen consumption in patients with septic shock, provided the fractional splanchnic flow is not already high before treatment.
authors.affiliation: Department of Anesthesia and Critical Care Medicine, Friedrich Schiller University, Jena, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Meier-Hellmann
authors.forename: D L
authors.initials: DL
authors.lastname: Bredle
authors.forename: M
authors.initials: M
authors.lastname: Specht
authors.forename: C
authors.initials: C
authors.lastname: Spies
authors.forename: L
authors.initials: L
authors.lastname: Hannemann
authors.forename: K
authors.initials: K
authors.lastname: Reinhart
mesh_terms: D000328:Adult; D000368:Aged; D001784:Blood Gas Analysis; D004298:Dopamine / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects*; D011446:Prospective Studies; D012044:Regression Analysis; D012772:Shock, Septic / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D013152:Splanchnic Circulation / Q000187:drug effects*; D018709:Statistics, Nonparametric; D016019:Survival Analysis
chemical_list: D004298:Dopamine