title: Genetically engineered mice as animal models for NIDDM.
abstract: Genetically engineered animals carrying defined alterations in their genome can represent invaluable tools for better understanding complex polygenic diseases such as non-insulin-dependent diabetes mellitus (NIDDM) at the molecular level. The structure or expression of a number of genes potentially involved in insulin action or pancreatic beta-cell function have recently been altered in the mouse using transgenic or gene-targeting approaches. The obtention of such mice is the first step towards the development of animal models carrying multiple gene defects which would be very useful in NIDDM research.
authors.affiliation: Institut Cochin de Génétique Moléculaire, INSERM U257, Paris, France.
authors.forename: R L
authors.initials: RL
authors.lastname: Joshi
authors.forename: B
authors.initials: B
authors.lastname: Lamothe
authors.forename: D
authors.initials: D
authors.lastname: Bucchini
authors.forename: J
authors.initials: J
authors.lastname: Jami
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D004195:Disease Models, Animal; D018390:Gene Targeting; D005818:Genetic Engineering; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007515:Islets of Langerhans / Q000503:physiopathology; D051379:Mice; D008822:Mice, Transgenic
chemical_list: D007328:Insulin