title: Distribution of endothelin-1-like activity in the cochlea of normal guinea pigs.
abstract: Distribution of endothelin-1 (ET-1) in the cochlea of normal guinea pigs was determined by immunohistochemistry. ET-1 activity was identified with the mouse anti-human ET-1 IgG1 monoclonal antibody. ET-1 activity was distributed in the modiolus, spiral ligament, stria vascularis, spiral prominence. Reissner's membrane, supporting cells of the organ of Corti and spiral ganglion cells. These findings suggest that ET-1 may be involved in the regulation of fluid volume and ions of the cochlea.
authors.affiliation: Department of Otolaryngology, Nippon Medical School, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Jinnouchi
authors.forename: S
authors.initials: S
authors.lastname: Tomiyama
authors.forename: R
authors.initials: R
authors.lastname: Pawankar
authors.forename: T
authors.initials: T
authors.lastname: Ikezono
authors.forename: T
authors.initials: T
authors.lastname: Yagi
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D003051:Cochlea / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D019332:Endothelin-1 / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006168:Guinea Pigs; D018072:Hair Cells, Auditory, Outer / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D007150:Immunohistochemistry; D009925:Organ of Corti / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D013136:Spiral Ganglion / Q000166:cytology / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D019332:Endothelin-1