title: [Pubertal development after pediatric heart transplantation].
abstract: Twenty-one children and adolescents underwent orthotopic cardiac transplantation at the Hôpital Sainte-Justine between July 1984 and June 1993. Of those patients, 16 (4 girls and 12 boys) who survived more than one year after the procedure were followed prospectively for documentation of onset and progression of puberty. The immunosuppressive therapy included cyclosporine, azathioprine and prednisone. Subjects were evaluated at 6 month intervals for the study of: pubertal development according to staging by the method of Marshall and Tanner and hormonal profile (FSH, LH, testosterone, DHEAS). Despite a stagnation of pubertal signs before surgery, puberty carried on and progressed normally postoperatively. The urinary levels of gonadotropins rose to adequate levels for age. Testosterone levels in boys were related to the progression of secondary sexual characteristics. Levels of DHEAS were drastically reduced, most likely because of the supraphysiological doses of oral glucocorticoids. Our results indicate that after pediatric heart transplantation, puberty progresses normally at adolescence.
authors.affiliation: Service de Chirurgie Cardiovasculaire, Hôpital Sainte-Justine, Université de Montréal, Québec, Canada.
authors.forename: E
authors.initials: E
authors.lastname: De Broux
authors.forename: C
authors.initials: C
authors.lastname: Huot
authors.forename: S
authors.initials: S
authors.lastname: Vobecky
authors.forename: S
authors.initials: S
authors.lastname: Chartrand
authors.forename: C
authors.initials: C
authors.lastname: Dupuis
authors.forename: C
authors.initials: C
authors.lastname: Chartrand
mesh_terms: D000293:Adolescent; D001379:Azathioprine / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D016572:Cyclosporine / Q000008:administration & dosage; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D005260:Female; D006065:Gonadotropins, Pituitary / Q000097:blood / Q000652:urine; D006084:Graft Rejection / Q000517:prevention & control; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D011241:Prednisone / Q000008:administration & dosage; D011446:Prospective Studies; D011627:Puberty; D012737:Sex Factors; D013739:Testosterone / Q000097:blood
chemical_list: D006065:Gonadotropins, Pituitary; D007166:Immunosuppressive Agents; D013739:Testosterone; D019314:Dehydroepiandrosterone Sulfate; D016572:Cyclosporine; D001379:Azathioprine; D011241:Prednisone