A urochordate putative homolog of human EB1, the protein which binds APC1.
The human EBI protein has been cloned by virtue of its interaction with the C-terminus of the APC (adenomatous polyposis coli) protein, whose C-terminal truncated forms have been shown to accompany sporadic and familial forms of colorectal cancer. We have cloned a putative EBI homolog from Botryllus schlosseri (Urochordata. Ascidiacea). The deduced protein is 287 amino acids long, and is identical with 48% of the residues in human EBI and 24-25% in two yeast hypothetical proteins. We propose that such a high degree of conservation among EBI homologs is indicative of an essential regulatory mechanism in eukaryotic cells.
Pancer
Z
Z
Abteilung für Angewandte Molekularbiologie, Universität, Mainz, Germany.
Cooper
E L
EL
Müller
W E
WE
D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins; D001483:Base Sequence; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011506:Proteins / Q000235:genetics*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D014561:Urochordata / Q000737:chemistry*
D001426:Bacterial Proteins; C104097:EB1 protein, Botryllus schlosseri; D011506:Proteins