title: Effects of contrast dose, delayed imaging, and magnetization transfer saturation on gadolinium-enhanced MR imaging of brain lesions.
abstract: This paper discusses the types of paramagnetic agents available for clinical brain imaging and reviews investigations that have sought to optimize the use of these agents by varying the administered dose, delaying the imaging time after contrast administration, and altering image contrast by using magnetization transfer saturation pulses.
authors.affiliation: Department of Radiology, Indiana University School of Medicine, Indianapolis, USA.
authors.forename: V P
authors.initials: VP
authors.lastname: Mathews
authors.forename: K S
authors.initials: KS
authors.lastname: Caldemeyer
authors.forename: J L
authors.initials: JL
authors.lastname: Ulmer
authors.forename: H
authors.initials: H
authors.lastname: Nguyen
authors.forename: W T
authors.initials: WT
authors.lastname: Yuh
mesh_terms: D001812:Blood-Brain Barrier; D001927:Brain Diseases / Q000175:diagnosis* / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis / Q000556:secondary; D002544:Cerebral Infarction / Q000175:diagnosis; D002986:Clinical Trials as Topic; D003287:Contrast Media / Q000008:administration & dosage*; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D005682:Gadolinium / Q000008:administration & dosage*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D005682:Gadolinium