Strategic proposals for predicting drug-drug interactions during new drug development: based on sixteen deaths caused by interactions of the new antiviral sorivudine with 5-fluorouracil prodrugs.
Watabe
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Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan.
D000818:Animals; D000998:Antiviral Agents / Q000009:adverse effects*; D001086:Arabinofuranosyluracil / Q000009:adverse effects / Q000031:analogs & derivatives*; D015195:Drug Design; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005472:Fluorouracil / Q000009:adverse effects*; D006562:Herpes Zoster / Q000188:drug therapy; D006801:Humans; D007564:Japan; D011355:Prodrugs / Q000009:adverse effects*; D051381:Rats; D018570:Risk Assessment
D000998:Antiviral Agents; D011355:Prodrugs; D001086:Arabinofuranosyluracil; C031368:sorivudine; D005472:Fluorouracil