Comparative serum estradiol profiles from a new once-a-week transdermal estradiol patch and a twice-a-week transdermal estradiol patch.
Two identical open-label, randomized crossover studies were conducted to compare serum estradiol profiles from the new 12.5- and 25-cm2 once-a-week adhesive patches with those from the 10- and 20-cm2 commercially available twice-a-week Estraderm patches when applied as directed during a 1-week patch-wear period. Both studies were conducted in healthy postmenopausal women; serum estradiol levels were determined by gas chromatography/mass spectroscopy (GC/MS). Although both sizes of both patch treatments produced mean serum estradiol levels in the therapeutic range, the once-a-week patch provided more constant mean levels, avoiding large peak-to-trough fluctuations. As expected, the differences in mean serum estradiol concentrations between the two patch treatments occurred during the second application of the twice-a-week patch. Based on these results, the once-a-week drug in adhesive patch appears to be an acceptable means of hormone replacement therapy.
Harrison
L I
LI
Department of Pharmacokinetics and Drug Metabolism, 3M Pharmaceuticals, St. Paul, Minnesota 55144, USA.
Riedel
D J
DJ
Chang
S F
SF
Jacobson
J P
JP
Sellers
J A
JA
Kanniainen
C M
CM
Crowley
J K
JK
Hinderling
P H
PH
D000279:Administration, Cutaneous; D000368:Aged; D003692:Delayed-Action Preparations; D004958:Estradiol / Q000008:administration & dosage / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged
D003692:Delayed-Action Preparations; D004958:Estradiol