title: Mixture distribution and receiver operating characteristic analysis of bedside chest imaging with screen-film and computed radiography.
abstract: OBJECTIVE
  The authors demonstrated the use of mixture distribution analysis as an alternative to receiver operating characteristic (ROC) analysis in a clinical study, where independent verification of the imaging diagnosis is not always feasible.
  
  
  METHODS
  ROC and mixture distribution analyses were applied to the blind readings of four radiologists on a stratified, random sample of 95 screen-film radiographs and 95 computed radiographs of the chest obtained from a medical intensive care unit. The imaging diagnosis established by an expert panel was used as the truth for the ROC analysis, and agreement of ratings was used for the mixture distribution analysis.
  
  
  RESULTS
  Both methods yielded similar values for the proportion of correct diagnoses.
  
  
  CONCLUSIONS
  Mixture distribution analysis may be useful for comparing imaging techniques in situations where the true imaging diagnosis cannot be established with a method independent of that being evaluated.
authors.affiliation: Department of Radiology, University of Pennsylvania, Philadelphia, USA.
authors.forename: H L
authors.initials: HL
authors.lastname: Kundel
authors.forename: M
authors.initials: M
authors.lastname: Polansky
mesh_terms: D006801:Humans; D007362:Intensive Care Units; D019095:Point-of-Care Systems; D012372:ROC Curve; D013902:Radiography, Thoracic / Q000379:methods*; D016037:Single-Blind Method; D014057:Tomography, X-Ray Computed / Q000379:methods*