title: Asymptomatic lymphoma associated with elevation of immunoglobulin E.
abstract: BACKGROUND
  Elevation of immunoglobulin E (IgE) is rarely detected in patients with underlying malignancy. There has been only one report of such a finding in a patient with a T cell lymphoma and none to our knowledge in association with a B-cell lymphoma.
  
  
  OBJECTIVE
  To report a patient with elevation of IgE associated with a B-cell lineage lymphoma.
  
  
  METHODS
  Case report and review of literature.
  
  
  RESULTS
  A 73-year-old woman was found to have elevated IgE (11,766 IU/mL) in a routine evaluation for rhinitis. No underlying allergic diathesis or disease associated with IgE elevation was noted. Because of an abnormal lymphocyte profile, an extensive malignancy evaluation was performed which revealed a B-cell lymphoma.
  
  
  CONCLUSIONS
  B-cell lineage lymphoma can be associated with elevated of IgE and should be included in the differential diagnosis in a patient presenting with this finding.
authors.affiliation: Department of Pediatrics, University of South Florida/All Children's Hospital, St. Petersburg, USA.
authors.forename: A
authors.initials: A
authors.lastname: Koutsonikolis
authors.forename: N
authors.initials: N
authors.lastname: Day
authors.forename: W
authors.initials: W
authors.lastname: Chamizo
authors.forename: R A
authors.initials: RA
authors.lastname: Good
authors.forename: S J
authors.initials: SJ
authors.lastname: Kornfeld
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology* / Q000473:pathology*; D007073:Immunoglobulin E / Q000097:blood* / Q000276:immunology*; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology*
chemical_list: D007073:Immunoglobulin E