[Keratosis palmoplantaris varians et punctata. Clinical variability of an single genetic defect?].
Palmoplantar keratodermia (PPK) varians and PPK punctata are considered different entities within the group of hereditary palmoplantar keratodermas. Keratosis punctata of the palmar creases constitutes a localized form of keratodermia palmoplantaris punctata. We describe a 31-year-old man exhibiting both nummular and papular keratoses on the soles, as well as small punctate keratoses confined to the palmar creases. In view of the co-occurrence of these two types of PPK, the question arises whether keratosis palmoplantaris of the varians and the punctate type represent distinct entities or represent variable manifestations of the same gene defect.
Lucker
G P
GP
Dermatologische Klinik, Universitätsspital, Nijmegen, Niederlande.
Steijlen
P M
PM
D000328:Adult; D005838:Genotype; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D010641:Phenotype; D012867:Skin / Q000473:pathology