Tying loose ends: roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks.
A convergence of information from biochemistry, yeast and mammalian genetics, immunology, and radiation biology has permitted identification of some of the protein participants - Ku, DNA-PK, XRCC4 - and the reaction intermediates in DNA end joining, suggesting how broken chromosomal ends may be recognized and repaired in eukaryotic cells. Some components may be defective in inherited disorders.
Lieber
M R
MR
Division of Molecular Oncology, Departments of Pathology, Biochemistry and Molecular Biophysics, Campus Box 8118, Washington University Schoolof Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA. lieber@pathology.wustl.edu
Grawunder
U
U
Wu
X
X
Yaneva
M
M
D000818:Animals; D034961:Antigens, Nuclear; D004265:DNA Helicases; D004260:DNA Repair / Q000502:physiology*; D051747:DNA-Activated Protein Kinase; D004268:DNA-Binding Proteins / Q000502:physiology*; D000072200:Ku Autoantigen; D009687:Nuclear Proteins / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins; D015003:Yeasts / Q000235:genetics
D034961:Antigens, Nuclear; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins; C081647:high affinity DNA-binding factor, S cerevisiae; D051747:DNA-Activated Protein Kinase; D017346:Protein Serine-Threonine Kinases; D004265:DNA Helicases; C106893:XRCC5 protein, human; C000606509:Xrcc6 protein, human; D000072200:Ku Autoantigen