title: Successful hematopoietic reconstitution by transplantation of umbilical cord blood cells in a transfusion-dependent child with Diamond-Blackfan anemia.
abstract: A 4-year-old boy with Diamond-Blackfan anemia and a history of multiple transfusions underwent umbilical cord blood transplantation from his HLA-identical female sibling born by vaginal delivery at 38 weeks. The patient was prepared with busulfan, cyclophosphamide and antilymphocyte globulin. Methotrexate and cyclosporin A were given for the prophylaxis of GVHD. Regimen-related toxicity was not observed and successful engraftment occurred, including the erythroid series. No evidence of acute or chronic GVHD has been observed for 14 months after transplantation. This is the first case of successful umbilical cord blood transplantation to a patient with Diamond-Blackfan anemia.
authors.affiliation: Department of Pediatrics, Mie University, School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Bonno
authors.forename: E
authors.initials: E
authors.lastname: Azuma
authors.forename: T
authors.initials: T
authors.lastname: Nakano
authors.forename: M
authors.initials: M
authors.lastname: Higashikawa
authors.forename: H
authors.initials: H
authors.lastname: Kawaski
authors.forename: H
authors.initials: H
authors.lastname: Nishihara
authors.forename: M
authors.initials: M
authors.lastname: Obata
authors.forename: M
authors.initials: M
authors.lastname: Umemoto
authors.forename: H
authors.initials: H
authors.lastname: Sakatoku
authors.forename: Y
authors.initials: Y
authors.lastname: Komada
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: M
authors.initials: M
authors.lastname: Nagai
authors.forename: M
authors.initials: M
authors.lastname: Sakurai
mesh_terms: D001803:Blood Transfusion; D002675:Child, Preschool; D005199:Fanconi Anemia / Q000628:therapy*; D005260:Female; D005312:Fetal Blood; D016332:Fetal Tissue Transplantation; D006410:Hematopoiesis; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male