[The antioxidative properties of furosemide in renal ischemia].
The intensity of lipid peroxidation increases in ischemic damage to the kidneys. That furosemide possesses antioxidant properties was established on a model of in vitro total kidney ischemia. It is supposed that the protective effect of furosemide in ischemic damage is due to inhibition of lipid peroxidation. However, such an effect is not encountered in kidney ischemia in an intact organism. Furosemide does not prevent the fall of selenium concentration in the kidney after ischemia.
Lebedev
A A
AA
Petrenko
N A
NA
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005665:Furosemide / Q000494:pharmacology / Q000627:therapeutic use*; D007511:Ischemia / Q000188:drug therapy* / Q000378:metabolism; D007668:Kidney / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D012643:Selenium / Q000378:metabolism
D000975:Antioxidants; D008315:Malondialdehyde; D005665:Furosemide; D012643:Selenium