title: Efficacy of nonpharmacologic interventions in adults with high-normal blood pressure: results from phase 1 of the Trials of Hypertension Prevention. Trials of Hypertension Prevention Collaborative Research Group.
abstract: Phase 1 of the Trials of Hypertension Prevention was conducted in 2182 adults, aged 35-54 y, with diastolic blood pressure of 80-89 mm Hg to test the feasibility and blood pressure-lowering effects of seven nonpharmacologic interventions (weight loss, sodium reduction, stress management, and supplementation with calcium, magnesium, potassium, and fish oil). At 6 and 18 mo, weight loss and sodium reduction were well-tolerated and produced significant declines in systolic and diastolic blood pressures (-2.9/-2.4 and -2.1/-1.2 mm Hg for weight loss and sodium reduction, respectively, at 18 mo). None of the other interventions lowered blood pressure significantly at either the 6- or 18-mo follow-up visits. These results suggest that both weight loss and sodium reduction provide an effective means to prevent hypertension. The long-term effects of both of these interventions are being tested in phase 2 of the trial.
authors.affiliation: Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University School of Hygiene and Public Health, Baltimore, USA. pwhelton@mailhost.tcs.tulane.edu
authors.forename: P K
authors.initials: PK
authors.lastname: Whelton
authors.forename: S K
authors.initials: SK
authors.lastname: Kumanyika
authors.forename: N R
authors.initials: NR
authors.lastname: Cook
authors.forename: J A
authors.initials: JA
authors.lastname: Cutler
authors.forename: N O
authors.initials: NO
authors.lastname: Borhani
authors.forename: C H
authors.initials: CH
authors.lastname: Hennekens
authors.forename: L H
authors.initials: LH
authors.lastname: Kuller
authors.forename: H
authors.initials: H
authors.lastname: Langford
authors.forename: D W
authors.initials: DW
authors.lastname: Jones
authors.forename: S
authors.initials: S
authors.lastname: Satterfield
authors.forename: N L
authors.initials: NL
authors.lastname: Lasser
authors.forename: J D
authors.initials: JD
authors.lastname: Cohen
mesh_terms: D000328:Adult; D001794:Blood Pressure; D001835:Body Weight; D004039:Diet, Sodium-Restricted; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000517:prevention & control*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011788:Quality of Life; D012307:Risk Factors; D012964:Sodium / Q000652:urine; D012982:Sodium, Dietary / Q000008:administration & dosage; D013312:Stress, Physiological / Q000517:prevention & control; D015431:Weight Loss
chemical_list: D012982:Sodium, Dietary; D012964:Sodium