Protection by trehalose of DNA from radiation damage.
The most serious damage to cells exposed to radiation is attributed mostly to effects on the structure of cellular DNA. We found that trehalose protects DNA from irradiation. In the presence of 10 mM trehalose, DNA can be protected from about 4 times higher doses of beta- and gamma-ray irradiation. The protective effect increases with the amount of the sugar. Other disaccharides, sucrose, and maltose had similar effects.
Yoshinaga
K
K
Department of Chemistry, Faculty of Science, Shizuoka University, Japan.
Yoshioka
H
H
Kurosaki
H
H
Hirasawa
M
M
Uritani
M
M
Hasegawa
K
K
D001610:Beta Particles; D004249:DNA Damage / Q000187:drug effects* / Q000528:radiation effects*; D004270:DNA, Circular / Q000737:chemistry / Q000187:drug effects / Q000528:radiation effects; D004277:DNA, Single-Stranded / Q000737:chemistry / Q000187:drug effects / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004587:Electrophoresis, Agar Gel; D005720:Gamma Rays; D008320:Maltose / Q000494:pharmacology; D011835:Radiation Protection / Q000379:methods*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D012680:Sensitivity and Specificity; D013395:Sucrose / Q000494:pharmacology; D014199:Trehalose / Q000494:pharmacology*
D004270:DNA, Circular; D004277:DNA, Single-Stranded; D011837:Radiation-Protective Agents; D013395:Sucrose; D008320:Maltose; D014199:Trehalose