title: [Out-of-hospital buffer therapy in heart arrest].
abstract: The effects of infusing a buffer solution on resuscitability and outcome were tested in patients during out-of-hospital cardiac arrest. 502 adults with ventricular fibrillation or asystole with failure of first attempt at defibrillation were entered into a prospective, randomized, double-blind, controlled trial where one group received buffer and the other group placebo (saline). 87 of 245 (36%) patients who received a buffer were admitted to hospital and 24 (10%) were discharged alive, as against 92 of 257 (36%) admitted to hospital and 35 (14%) discharged alive for those who received placebo. Only 16 of the 502 patients had arterial alkalosis on arrival at hospital and no patient had a positive base excess. Patients resuscitated after out-of-hospital cardiac arrest had metabolic acidosis but buffer therapy did not improve outcome.
authors.affiliation: Anestesiavdelingen, Ullevål sykehus, Oslo.
authors.forename: T
authors.initials: T
authors.lastname: Dybvik
authors.forename: T
authors.initials: T
authors.lastname: Strand
authors.forename: P A
authors.initials: PA
authors.lastname: Steen
mesh_terms: D000328:Adult; D000368:Aged; D002021:Buffers; D016887:Cardiopulmonary Resuscitation; D004311:Double-Blind Method; D004632:Emergency Medical Services; D005260:Female; D006323:Heart Arrest / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009664:Norway; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D002021:Buffers