title: [A chronobiological approach to correcting disorders of time organization of clofelin hemodynamics in patients with stage II essential hypertension].
abstract: The efficacy of clofelin chronotherapy was assessed in 21 patients with stage II essential hypertension with due consideration for the circadian and circaseptan acrophase of arterial pressure (AP). AP and stroke volume were measured by tetrapolar chest rheography. Daily profiles of the major hemodynamic parameters were assessed at 8.00, 12.00, 16.00, 20.00, and 24.00 o'clock for 7 days prior to and 12 days after chronotherapy with clofelin in a single daily dose of 0.0375 to 0.075 mg with due consideration for the circadian and circaseptan acrophase of AP. The circadian and circaseptan rhythm of the basic parameters of circulation was disordered before therapy. Clofelin administered 1.5 to 2 h before the acrophase of circadian and circaseptan rhythm of AP brought about a stable hypotensive effect and positive time course of clinical symptoms on day 4 of chronotherapy; in addition, it improved the chronostructure of the circadian rhythms of the major hemodynamic parameters.
authors.affiliation: Moscow City Clinic #60, Laboratory of Chronobiology of Minnesota University, USA.
authors.forename: K K
authors.initials: KK
authors.lastname: Tokbaeva
authors.forename: R M
authors.initials: RM
authors.lastname: Zaslavskaia
authors.forename: F
authors.initials: F
authors.lastname: Khalberg
authors.forename: M M
authors.initials: MM
authors.lastname: Teiblium
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D019454:Chronotherapy / Q000379:methods*; D003000:Clonidine / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010992:Plethysmography, Impedance; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D003000:Clonidine