Cell anchorage and the cytoskeleton as partners in growth factor dependent cell cycle progression.
Several studies in the past year have shown that the cell cycle events typically attributed to a response to growth factors actually require signals provided by both growth factors and the extracellular matrix. Moreover, at least some of these matrix-based effects seem to involve matrix-dependent organization of the cytoskeleton rather than cell adhesion per se. Overall, these studies are providing new insights into the long-appreciated concepts of anchorage- and shape-dependent growth.
Assoian
R K
RK
Department of Cell Biology and Anatomy, Cancer Center, University of Miami School of Medicine, PO Box 016960 (R124), Miami, FL 33101, USA. rassoian@mednet.med.miami.edu
Zhu
X
X
D002448:Cell Adhesion / Q000502:physiology*; D002453:Cell Cycle / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology*; D006133:Growth Substances / Q000502:physiology*
D006133:Growth Substances