title: [Regimens for administering plasminogen activators].
abstract: The results of biochemical and clinical studies of the dosage regimens for plasminogen activators were analyzed. The tendency to administer plasminogen activators in a bolus was revealed, so as to provide early medical aid and reduce the term of infusion to attain complete reperfusion of the occluded vessel. The importance of developing plasminogen activators of the next generation by chemical and biological synthesis and applying them according to a simplified dosage schedule was emphasized. It was pointed out that thrombolytic compositions promoting a favorable long-term prognosis in patients with cardiovascular diseases must be formed.
authors.forename: A V
authors.initials: AV
authors.lastname: Maksimenko
mesh_terms: D000818:Animals; D004359:Drug Therapy, Combination; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D010960:Plasminogen Activators / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D005343:Fibrinolytic Agents; D010960:Plasminogen Activators