Evidence for rhythmic firing being caused by feedback inhibition in pinch-inhibited raphe magnus neurons.
Raphe magnus cells that are inhibited by skin pinching fire spontaneously with strongly preferred interspike intervals (mean cycle 85 ms, n = 33). In pentobarbital-anesthetized rats, mid-cycle cathodal activation (0.3 ms) or end-cycle anodal black (30-60 ms) at approximately 1 Hz through the extracellular recording microelectrode delayed expected spikes; respective post-stimulus latencies peaked on average at 1.17 (n = 14) and 0.40 (n = 6) cycles. Feedback inhibition following random excitation, but not free-running intrinsic or afferent oscillations, may therefore cause the rhythm.
Hentall
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Department of Biomedical Sciences, University of Illinois, College of Medicine at Rockford 61107-1897, USA. ianh@uic.edu
White
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D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004594:Electrophysiology; D005110:Extracellular Space / Q000187:drug effects / Q000502:physiology; D005246:Feedback; D005260:Female; D008839:Microelectrodes; D009474:Neurons / Q000502:physiology*; D010146:Pain / Q000503:physiopathology*; D010812:Physical Stimulation; D011903:Raphe Nuclei / Q000166:cytology / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley