Syndrome of inappropriate secretion of antidiuretic hormone in two elderly women with elevated serum fluoxetine.
OBJECTIVE
Fluoxetine is widely prescribed for depressed patients. Hyponatremia secondary to inappropriate secretion of antidiuretic hormone has been reported in a few cases associated with routine use of fluoxetine, especially in elderly patients. The mechanism has been postulated to be linked to the inappropriate secretion of antidiuretic hormone. Serum concentrations of antidiuretic hormone and fluoxetine have not been reported in previously published reports.


METHODS
We report two new cases of severe and reversible hyponatremia associated with routine use of fluoxetine therapy in two elderly women. Fluoxetine-induced inappropriate secretion of antidiuretic hormone was confirmed by elevated serum concentrations of antidiuretic hormone and fluoxetine.
Girault
C
C
Medical Intensive Care Unit, Charles Nicolle University Hospital, Rouen, France.
Richard
J C
JC
Chevron
V
V
Goullé
J P
JP
Droy
J M
JM
Bonmarchand
G
G
Leroy
J
J
D000368:Aged; D000369:Aged, 80 and over; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects* / Q000097:blood; D000075202:Contraindications; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects* / Q000097:blood; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced / Q000209:etiology*; D007177:Inappropriate ADH Syndrome / Q000175:diagnosis* / Q000628:therapy; D014667:Vasopressins / Q000097:blood
D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine; D014667:Vasopressins