Prostate-specific antigen-producing cells in the bone marrow of a patient with early-stage prostate cancer.
This report describes a clinical case that supports the hypothesis that occult bone marrow disease may exist even in early-stage and low prostate-specific antigen (less than 10 ng/mL) prostate cancer. The concept of adding androgen suppression to definitive local therapy in these patients is discussed.
D'Amico
A V
AV
Joint Center for Radiation Therapy, Harvard Medical School, North Dartmouth, Massachusetts 02747, USA.
Matelski
H
H
O'Leary
M
M
Sussman
B
B
D000368:Aged; D001853:Bone Marrow / Q000378:metabolism*; D001854:Bone Marrow Cells; D019046:Bone Marrow Neoplasms / Q000378:metabolism / Q000473:pathology / Q000556:secondary; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D017430:Prostate-Specific Antigen / Q000096:biosynthesis*; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology
D017430:Prostate-Specific Antigen