title: Is TNF really involved in cachexia?
abstract: A review on the possible involvement of tumor necrosis factor-alpha (TNF) in cachexia is presented. While this cytokine is definitely linked to sepsis and tumor-associated weight loss in some experimental models, other cytokines, such as interleukin-6 (IL-6) or interferon-gamma (IFN-gamma), alone or in combination with TNF, may also play an important role in the development of cachexia.
authors.affiliation: Department of Biochemistry and Physiology, Facultat de Biologia, Universitat de Barcelona, Spain.
authors.forename: C
authors.initials: C
authors.lastname: García-Martínez
authors.forename: P
authors.initials: P
authors.lastname: Costelli
authors.forename: F J
authors.initials: FJ
authors.lastname: López-Soriano
authors.forename: J M
authors.initials: JM
authors.lastname: Argilés
mesh_terms: D000818:Animals; D002100:Cachexia / Q000209:etiology / Q000276:immunology*; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
chemical_list: D014409:Tumor Necrosis Factor-alpha