title: Comparison of scintigraphy and lactulose breath hydrogen test for assessment of orocecal transit: lactulose accelerates small bowel transit.
abstract: The lactulose breath test (LBT) and gastroenterocolonic scintigraphy (GECS) can both be used to measure orocecal transit time (OCTT). The aims of this study were (1) to measure OCTT by LBT and GECS and (2) to determine whether lactulose alters orocecal transit.
  
  
  METHODS
  Eight normal subjects underwent simultaneous breath hydrogen testing, GECS, and duodenal manometry while receiving either 10 g lactulose or placebo with a radiolabeled solid/liquid test meal during two studies. There was a good correlation between OCTT by LBT and GECS when performed simultaneously (r = 0.95; P < 0.001). OCTT by GECS with lactulose was significantly faster (P = 0.004) than by GECS without lactulose, despite no change in gastric emptying of liquids and slowing of gastric emptying of solids (P = 0.02). The postprandial duodenal motility index was greater with lactulose than with placebo (P = 0.031). This study demonstrates that LBT and GECS (without lactulose) are not equivalent measures of OCTT. The standard LBT accelerates OCTT and slows gastric emptying. Therefore, lactulose has a direct accelerating effect on small intestinal transit.
authors.affiliation: Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Miller
authors.forename: H P
authors.initials: HP
authors.lastname: Parkman
authors.forename: J L
authors.initials: JL
authors.lastname: Urbain
authors.forename: K L
authors.initials: KL
authors.lastname: Brown
authors.forename: D J
authors.initials: DJ
authors.lastname: Donahue
authors.forename: L C
authors.initials: LC
authors.lastname: Knight
authors.forename: A H
authors.initials: AH
authors.lastname: Maurer
authors.forename: R S
authors.initials: RS
authors.lastname: Fisher
mesh_terms: D000328:Adult; D001944:Breath Tests; D004064:Digestive System / Q000000981:diagnostic imaging*; D004386:Duodenum / Q000502:physiology; D005260:Female; D005746:Gastric Emptying; D005769:Gastrointestinal Motility; D005772:Gastrointestinal Transit; D006801:Humans; D006859:Hydrogen / Q000032:analysis; D007792:Lactulose; D008297:Male; D008365:Manometry; D011877:Radionuclide Imaging; D013270:Stomach / Q000502:physiology
chemical_list: D007792:Lactulose; D006859:Hydrogen