A biochemical perspective of methotrexate neurotoxicity with insight on nonfolate rescue modalities.
Quinn
C T
CT
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235-9063, USA.
Kamen
B A
BA
D000208:Acute Disease; D000241:Adenosine / Q000378:metabolism; D001708:Biopterins / Q000378:metabolism; D002908:Chronic Disease; D005493:Folic Acid Antagonists / Q000009:adverse effects*; D006710:Homocysteine / Q000378:metabolism; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects*; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000145:classification; D019384:Nucleic Acid Synthesis Inhibitors / Q000009:adverse effects*
D005493:Folic Acid Antagonists; D019384:Nucleic Acid Synthesis Inhibitors; D006710:Homocysteine; D001708:Biopterins; D000241:Adenosine; D008727:Methotrexate