title: Seroprevalence of antibodies to Sarcocystis neurona in horses residing in a county of southeastern Pennsylvania.
abstract: OBJECTIVE
  To determine seroprevalence of Sarcocystis neurona-specific antibodies in a population of horses residing in Chester County, Pa.
  
  
  METHODS
  Prevalence survey.
  
  
  METHODS
  117 serum samples from selected members of a population of 580 Thoroughbred horses.
  
  
  METHODS
  Serum was analyzed for antibodies to Sarcocystic neurona, using a western blot. Information regarding age, sex, and housing of horse was obtained by questionnaire. Data were analyzed, using multivariable logistic regression.
  
  
  RESULTS
  Seroprevalence was 45.3% (95% CI, 36.3 to 54.3%). A relationship was not found between seroprevalence and sex of horse. Seroprevalence was greater in older horses (logistic regression; P = 0.16).
  
  
  CONCLUSIONS
  High seroprevalence of antibodies to S neurona and the lack of neurologic deficits among horses sampled indicate that positive results of serologic examination alone are of limited value for diagnosis of equine protozoal myeloencephalitis. Clinical signs consistent with the disease are the most important consideration in accurate diagnosis.
authors.affiliation: Department of Medicine, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square 19348-1692, USA.
authors.forename: B G
authors.initials: BG
authors.lastname: Bentz
authors.forename: D E
authors.initials: DE
authors.lastname: Granstrom
authors.forename: S
authors.initials: S
authors.lastname: Stamper
mesh_terms: D017677:Age Distribution; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D015153:Blotting, Western / Q000662:veterinary; D004679:Encephalomyelitis / Q000453:epidemiology / Q000276:immunology / Q000662:veterinary*; D005260:Female; D006734:Horse Diseases / Q000453:epidemiology* / Q000276:immunology; D006736:Horses; D016015:Logistic Models; D008297:Male; D010414:Pennsylvania / Q000453:epidemiology; D015995:Prevalence; D012522:Sarcocystis / Q000276:immunology*; D012523:Sarcocystosis / Q000453:epidemiology / Q000276:immunology / Q000662:veterinary*; D016036:Seroepidemiologic Studies; D017678:Sex Distribution; D011795:Surveys and Questionnaires
chemical_list: D000913:Antibodies, Protozoan