title: Intrahepatic cholangiocarcinoma: MRI and pathologic correlation in 14 patients.
abstract: OBJECTIVE
  Our goal was to determine the MR features of intrahepatic cholangiocarcinoma and to correlate them with pathologic findings in a surgical series.
  
  
  METHODS
  MRI in 14 patients with intrahepatic cholangiocarcinoma who had undergone resection was reviewed. All patients had T1- and T2-weighted SE sequences. Contrast-material-enhanced MRI was performed in 12 cases. Comparison between findings at MRI and pathologic examination was made.
  
  
  RESULTS
  MRI depicted all the lesions but one satellite nodule of 2 cm diameter. All lesions were hypointense relative to the liver on T1-weighted images. On T2-weighted images, the tumors were predominantly isointense or slightly hyperintense relative to liver parenchyma in nine cases (64%) and were strongly hyperintense in five cases (36%). Central hypointense areas or bands were seen in eight cases. No capsule was detected. On contrast-enhanced MR studies, all lesions had progressive and concentric filling with contrast material. Associated findings such as vascular encasement, focal liver atrophy, or dilatation of intrahepatic bile ducts were observed in 10 cases (71%). Comparison with pathologic examination revealed that lesion signal intensity on T2-weighted MR images was due mostly to the amount of fibrosis, necrosis, and mucous secretion within the lesion. The nine isointense or slightly hyperintense lesions contained abundant fibrosis and had a low content of mucous secretion or necrosis, whereas the five hyperintense lesions contained low or moderate fibrosis and prominent mucous secretion and/or necrosis.
  
  
  CONCLUSIONS
  Our study suggests that the MR features of intrahepatic cholangiocarcinoma are well correlated with pathologic findings, but are nonspecific. Associated findings may strengthen the diagnosis of intrahepatic cholangiocarcinoma at MRI.
authors.affiliation: Department of Radiology, Hôpital Beaujon, Clichy, France.
authors.forename: V
authors.initials: V
authors.lastname: Vilgrain
authors.forename: B E
authors.initials: BE
authors.lastname: Van Beers
authors.forename: J F
authors.initials: JF
authors.lastname: Flejou
authors.forename: J
authors.initials: J
authors.lastname: Belghiti
authors.forename: M
authors.initials: M
authors.lastname: Delos
authors.forename: A L
authors.initials: AL
authors.lastname: Gautier
authors.forename: M
authors.initials: M
authors.lastname: Zins
authors.forename: A
authors.initials: A
authors.lastname: Denys
authors.forename: Y
authors.initials: Y
authors.lastname: Menu
mesh_terms: D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000473:pathology; D001653:Bile Ducts, Intrahepatic / Q000473:pathology*; D018281:Cholangiocarcinoma / Q000098:blood supply / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011859:Radiography