title: Mapping abnormal synovial vascular permeability in temporomandibular joint arthritis in the rabbit using MRI.
abstract: An automated method for two-dimensional spatial depiction (mapping) of quantitative physiological tissue characteristics derived from contrast-enhanced MRI was applied to a model of inflammatory disease represented by antigen-induced arthritis of the temporomandibular joint in the rabbit. Specifically, an established two-compartment kinetic model of unidirectional mass transport was implemented on a pixel-by-pixel basis to generate maps of tissue permeability surface area product (PS) and fractional blood volume (BV) based on dynamic MRI intensity data after administration of albumin-(Gd-DTPA)30, a prototype macromolecular contrast medium designed for blood pool enhancement. Maps of PS and BV in a disease model of induced arthritis clearly depicted zones of increased permeability (up to approximately 200 microliters/cc/h-compared to 25 microliters/cc/h in normal tissues).
authors.affiliation: Department of Radiology, University of California, San Francisco, USA.
authors.forename: F
authors.initials: F
authors.lastname: Demsar
authors.forename: C F
authors.initials: CF
authors.lastname: Van Dijke
authors.forename: B A
authors.initials: BA
authors.lastname: Kirk
authors.forename: S
authors.initials: S
authors.lastname: Kapila
authors.forename: C G
authors.initials: CG
authors.lastname: Peterfy
authors.forename: T P
authors.initials: TP
authors.lastname: Roberts
authors.forename: D M
authors.initials: DM
authors.lastname: Shames
authors.forename: S
authors.initials: S
authors.lastname: Tomazic
authors.forename: J
authors.initials: J
authors.lastname: Mann
authors.forename: R C
authors.initials: RC
authors.lastname: Brasch
mesh_terms: D000818:Animals; D001168:Arthritis / Q000473:pathology*; D002199:Capillary Permeability; D004195:Disease Models, Animal; D008279:Magnetic Resonance Imaging; D008297:Male; D011817:Rabbits; D013583:Synovial Membrane / Q000098:blood supply*; D013704:Temporomandibular Joint / Q000473:pathology*