title: Achievement of near-normal body weight as the prerequisite to normalize sex hormone-binding globulin concentrations in massively obese men.
abstract: OBJECTIVE
  To investigate the effects of weight loss on sex hormone-binding globulin (SHBG) in massively obese males and whether normal SHBG concentrations could be obtained regardless or not of the achievement of normal body weight values.
  
  
  METHODS
  Sera were collected for SHBG determination from 63 massively obese men, partly before they underwent biliopancreatic diversion (pre-op group = 11) and partly during the post-surgical follow up (post-op group = 52), and twenty normal weight healthy control men.
  
  
  METHODS
  Serum SHBG was measured using a noncompetitive liquid-phase immunoradiometric assay.
  
  
  RESULTS
  Baseline general characteristics were similar in both obese groups. Obese patients in the post-op group had lost 46.4 +/- 2.9 kg since they had undergone operation, namely during a mean period of 14.9 +/- 13.8 (range 1-58) months follow up. Obese groups had significantly lower SHBG than normal weight controls (66.2 +/- 18.6 nmol/l). However, pre-op obese (19.9 +/- 5.5 nmol/l) had significantly lower values than post-op obese subjects (45.5 +/- 24.8 nmol/l; P < 0.001). There were a highly significant correlation between SHBG and individual BMI values (r = -0.629; P < 0.001). Moreover, the post-op obese with BMI values lower or equal to 28 had significantly higher SHBG concentrations than those with BMI greater than 28 (62.8 +/- 22.2 nmol/l vs 32.1 +/- 19.6 nmol/l; P < 0.001), but not significantly different with respect to normal weight controls.
  
  
  CONCLUSIONS
  Massively obese men weight loss can completely reverse SHBG abnormalities, which can be restored to the normal range when near-normal body weight is achieved. Since reduced SHBG concentrations can be an independent risk factor for the development of diabetes and cardiovascular disease, this represents an additional benefit of weight loss program in massively obese individuals.
authors.affiliation: Dipartimento di Medicina Interna & Gastroenterologia, S. Orsola-Malpighi Hospital, University of Bologna, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Pasquali
authors.forename: V
authors.initials: V
authors.lastname: Vicennati
authors.forename: N
authors.initials: N
authors.lastname: Scopinaro
authors.forename: G
authors.initials: G
authors.lastname: Marinari
authors.forename: A
authors.initials: A
authors.lastname: Simonelli
authors.forename: R
authors.initials: R
authors.lastname: Flamia
authors.forename: F
authors.initials: F
authors.lastname: Casimirri
authors.forename: L
authors.initials: L
authors.lastname: Gagliardi
mesh_terms: D000328:Adult; D015904:Biliopancreatic Diversion; D001824:Body Constitution; D015992:Body Mass Index; D005500:Follow-Up Studies; D006801:Humans; D015592:Immunoradiometric Assay; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood* / Q000503:physiopathology / Q000601:surgery; D012016:Reference Values; D012738:Sex Hormone-Binding Globulin / Q000032:analysis* / Q000276:immunology; D015431:Weight Loss / Q000502:physiology*
chemical_list: D012738:Sex Hormone-Binding Globulin