[The effect of calcium channel blockers on activity in the sympathetic nerves, on the vasomotor reflex and on cerebral circulation].
Experiments on cats showed that calcium canal blockers of the dihydropyridine series (nimodipine, nifedipine) and, to a lesser measure diphenylpiperazine derivatives increase the activity in sympathetic nerves attributable to the central effect of the drugs. Cinnarizine had a diametrically opposite effect. Cinnarizine, nimodipine, and nifedipine reduced the reflex pressor response of the arterial pressure, whereas flunarizine mainly promoted the vasomotor reflex. Therefore, the central stimulating effect of flunarizine dominated over its peripheral vasodilative action. Nifedipine caused the most pronounced increase in cerebral blood flow, followed by nimodipine, flunarizin, and cinnarizine.
Gan'shina
T S
TS
Mirzoian
N R
NR
D000818:Animals; D017704:Baroreflex / Q000187:drug effects* / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology; D004095:Dihydropyridines / Q000494:pharmacology*; D004558:Electric Stimulation; D007668:Kidney / Q000294:innervation; D010879:Piperazines / Q000494:pharmacology*; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology; D013979:Tibial Nerve / Q000502:physiology; D013997:Time Factors
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D010879:Piperazines