title: Pheromone signalling and polarized morphogenesis in yeast.
abstract: Yeast cells respond to mating pheromones by activating a signal transduction pathway involving a seven transmembrane receptor/G protein complex linked to a mitogen-activated protein kinase module. Regulation of the G protein signal is controlled by the receptor and Sst2p; Sst2p may function as a GTPase-activating protein for the G protein alpha subunit. The Ste20 kinase acts in the linkage between the G protein and the MAP kinase module. Experiments suggest that binding of the Rho-like GTPase Cdc42p to Ste20p is not required for the mating response, yet is needed for the pseudohyphal growth response which involves many of the same kinases.
authors.affiliation: NRC Biotechnology Research Institute, 6100 Royalmount Avenue, Montreal Quebec, Canada H4P 2R2.
authors.forename: E
authors.initials: E
authors.lastname: Leberer
authors.forename: D Y
authors.initials: DY
authors.lastname: Thomas
authors.forename: M
authors.initials: M
authors.lastname: Whiteway
mesh_terms: D019204:GTP-Binding Proteins / Q000502:physiology; D010675:Pheromones / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000254:growth & development*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D010675:Pheromones; D019204:GTP-Binding Proteins