title: The effects of posterior fixation on internal intervertebral disc mechanics.
abstract: Posterior fixation of intervertebral discs is used to treat, and occasionally diagnose, discogenic pain since it is thought that it will reduce the internal loading of the discs in vitro. We measured the internal loading of ten intervertebral discs using stress profilometry under simulated physiological loads and then after posterior fixation. Partial discectomies were performed to simulate advanced disc degeneration and the sequence repeated. Posterior fixation had very little effect on the magnitude of the loads acting on the disc and none when disc degeneration was simulated. It did, however, reduce bulging of the anterior annulus under combined bending and compression (p < 0.03). Recent experiments in vivo have shown that discogenic pain is associated with abnormal bulging of the annulus which suggests that the clinical benefit of fixation may be due to this.
authors.affiliation: Department of Anatomy, University of Bristol, UK.
authors.forename: A G
authors.initials: AG
authors.lastname: Edwards
authors.forename: D S
authors.initials: DS
authors.lastname: McNally
authors.forename: R C
authors.initials: RC
authors.lastname: Mulholland
authors.forename: A E
authors.initials: AE
authors.lastname: Goodship
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001696:Biomechanical Phenomena; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007403:Intervertebral Disc / Q000601:surgery*; D007405:Intervertebral Disc Displacement / Q000503:physiopathology* / Q000601:surgery*; D008297:Male; D008722:Methods; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D013314:Stress, Mechanical