Stereoselective interaction of drug enantiomers with human serum transferrin in capillary zone electrophoresis.
Stereoselective interaction of drugs with human serum transferrin in capillary zone electrophoresis is described. The substances passed a pseudo-stationary protein zone applied in a coated capillary and the possible chiral separation of the optical isomers was followed. Drugs with different structures were screened and the enantiomers of bupivacaine, propranolol and promethazine as well as the diastereomers of labetalol were resolved. Racemic mixtures of atenolol and pindolol enantiomers could not be resolved under these conditions.
Kilár
F
F
Central Research Laboratory, Medical School, University of Pécs, Hungary. kilar@main.pote.hu
D002045:Bupivacaine / Q000737:chemistry / Q000378:metabolism; D019075:Electrophoresis, Capillary / Q000379:methods*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007741:Labetalol / Q000737:chemistry / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011398:Promethazine / Q000737:chemistry / Q000378:metabolism; D011433:Propranolol / Q000737:chemistry / Q000378:metabolism; D013237:Stereoisomerism; D014168:Transferrin / Q000378:metabolism*
D004364:Pharmaceutical Preparations; D014168:Transferrin; D011433:Propranolol; D011398:Promethazine; D007741:Labetalol; D002045:Bupivacaine