Epidural anaesthesia, ephedrine and phenylephrine in a patient taking moclobemide, a new monoamine oxidase inhibitor.
We report a case of low thoracic epidural and general anaesthesia in a patient receiving moclobemide, a new selective inhibitor of monoamine oxidase A. Intra-operative hypotension was initially treated with phenylephrine and then with ephedrine. The short half-life of moclobemide and its modest interaction with direct and indirect acting sympathomimetic drugs permit the use of epidural anaesthesia, since any associated hypotension can be safely treated.
Martyr
J W
JW
Department of Anaesthetics, King Edward Memorial Hospital, Subiaco, Perth, Australia.
Orlikowski
C E
CE
D000368:Aged; D000767:Anesthesia, Epidural / Q000009:adverse effects*; D000768:Anesthesia, General; D001549:Benzamides / Q000494:pharmacology*; D004347:Drug Interactions; D004809:Ephedrine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007022:Hypotension / Q000188:drug therapy* / Q000209:etiology; D020912:Moclobemide; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D010656:Phenylephrine / Q000627:therapeutic use; D013566:Sympathomimetics / Q000494:pharmacology / Q000627:therapeutic use*
D001549:Benzamides; D008996:Monoamine Oxidase Inhibitors; D013566:Sympathomimetics; D010656:Phenylephrine; D004809:Ephedrine; D020912:Moclobemide