title: Comparison technetium of Tc-99m disofenin cholescintigraphy with ultrasonography in the differentiation of biliary atresia from other forms of neonatal jaundice.
abstract: Technetium Tc-99m disofenin cholescintigraphy (CS) and ultrasonography (US) are two major clinical methods used in differentiating biliary atresia (BA) from neonatal jaundice. To compare the diagnostic utility of these two modalities, 66 patients with neonatal cholestasis (15 BA, 3 choledochal cyst (CC), 32 neonatal hepatitis, 13 prolonged jaundice, 2 total parenteral nutrition, and 1 sepsis) underwent Tc-99m disofenin CS and US. The diagnostic sensitivity, specificity, and accuracy of CS in differentiating BA from other forms of neonatal jaundice was 100%, 87.5%, and 90.5%, respectively, and for US 86.7%, 77.1%, and 79.4%, respectively. Tc-99m disofenin CS after premedication with phenobarbital and cholestyramine is a convenient and reliable method of differentiating BA from neonatal hepatitis, with a diagnostic accuracy superior to that of US. However, US is the initial imaging procedure of choice in patients presenting with jaundice to rule out anatomic anomalies such as CC.
authors.affiliation: Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan.
authors.forename: W Y
authors.initials: WY
authors.lastname: Lin
authors.forename: C C
authors.initials: CC
authors.lastname: Lin
authors.forename: S P
authors.initials: SP
authors.lastname: Changlai
authors.forename: Y Y
authors.initials: YY
authors.lastname: Shen
authors.forename: S J
authors.initials: SJ
authors.lastname: Wang
mesh_terms: D001656:Biliary Atresia / Q000000981:diagnostic imaging*; D002792:Cholestyramine Resin / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007098:Imino Acids; D007223:Infant; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000000981:diagnostic imaging*; D008297:Male; D015609:Organotechnetium Compounds; D010634:Phenobarbital / Q000627:therapeutic use; D011237:Predictive Value of Tests; D011292:Premedication; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D019785:Technetium Tc 99m Disofenin; D014463:Ultrasonography
chemical_list: D007098:Imino Acids; D015609:Organotechnetium Compounds; D002792:Cholestyramine Resin; D019785:Technetium Tc 99m Disofenin; D010634:Phenobarbital