Suppression of apoptotic DNA fragmentation in herpes simplex virus type 1-infected cells.
HEp-2 cells underwent apoptosis when the cells were incubated in medium containing sorbitol. Infection with herpes simplex virus type 1 (HSV-1) prior to the sorbitol treatment suppressed this apoptosis completely, indicating that HSV-1 carries an antiapoptosis gene. In addition, HSV-1 multiplication was restricted in these apoptotic HEp-2 cells.
Koyama
A H
AH
Department of Virology, School of Medicine, The University of Tokushima, Japan. koyama@basic.med.tokushima-u.ac.jp
Miwa
Y
Y
D017209:Apoptosis / Q000502:physiology*; D053938:DNA Fragmentation; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D006801:Humans; D016296:Mutagenesis; D013012:Sorbitol / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism
D014764:Viral Proteins; C066469:gamma 34.5 protein, Human herpesvirus 1; D013012:Sorbitol