Apoptosis in the striatum of rats following intraperitoneal injection of 3-nitropropionic acid.
The present study investigated the mechanism of cellular degeneration within the striatum following administration of the mitochondrial toxin, 3-nitropropionic (3-NP) acid. Internucleosomal fragmentation typical of apoptosis was present in the DNA of cells from the striatum of 3-NP-treated rats. DNA fragmentation was also evident in this region by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling. The data suggest that striatal cells die by apoptosis following administration of 3-NP.
Sato
S
S
Department of Neurological Surgery, School of Medicine, University of California, San Francisco 94143-0651, USA.
Gobbel
G T
GT
Honkaniemi
J
J
Li
Y
Y
Kondo
T
T
Murakami
K
K
Sato
M
M
Copin
J C
JC
Chan
P H
PH
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D053938:DNA Fragmentation / Q000187:drug effects; D004591:Electrophoresis, Polyacrylamide Gel; D006651:Histocytochemistry; D007274:Injections, Intraperitoneal; D008297:Male; D017072:Neostriatum / Q000166:cytology* / Q000187:drug effects; D009498:Neurotoxins / Q000008:administration & dosage / Q000494:pharmacology*; D009574:Nitro Compounds; D011422:Propionates / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D009498:Neurotoxins; D009574:Nitro Compounds; D011422:Propionates; C015392:3-nitropropionic acid