Migration of Leishmania donovani amastigotes in the cerebrospinal fluid.
A 10-year-old boy had been suffering from kala-azar (visceral leishmaniasis) for two and a half years. He failed to respond to all known anti-leishmanial treatment regimens. Even the drastic step of splenectomy failed to cure him. In November 1991, he presented with symptoms of meningitis. A diagnostic lumbar puncture revealed leishmanial amastigotes in his cerebrospinal fluid. The patient was finally cured with a course of amphotericin B, a drug known to cross the blood-brain barrier.
Prasad
L S
LS
Sen Medical Research Centre, Patna, India.
Sen
S
S
D000666:Amphotericin B / Q000627:therapeutic use*; D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D002555:Cerebrospinal Fluid / Q000469:parasitology*; D002648:Child; D006801:Humans; D007893:Leishmania donovani / Q000254:growth & development / Q000502:physiology*; D007898:Leishmaniasis, Visceral / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000469:parasitology; D008297:Male; D008581:Meningitis / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000469:parasitology*
D000981:Antiprotozoal Agents; D000666:Amphotericin B