title: [Outlook for using bacteria of the genus Bacillus for the design of new biopreparations].
abstract: The data evident of the promising use of Bacillus as a basis of new probiotics are presented. The criteria of the Bacillus screening among the other representatives of the exogenic microflora provided the design of a probiotic, named biosporin, which markedly differed from the other biological preparations based on aerobic sporulating bacteria. Biosporin proved to be an efficient agent in the treatment of acute intestinal infection due to pathogenic and opportunistic bacteria as well as in the treatment of dysbacteriosis of various etiology. A principally new probiotic, named subalin, with antibacterial and antiviral properties was designed on the basis of biosporin by the gene engineering. The data on the promising use of Bacillus in the composition of complex probiotics are also presented.
authors.forename: I B
authors.initials: IB
authors.lastname: Sorokulova
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001407:Bacillus / Q000502:physiology*; D001412:Bacillus subtilis; D001685:Biological Factors / Q000494:pharmacology; D001688:Biological Products; D015195:Drug Design; D006801:Humans; D007410:Intestinal Diseases / Q000188:drug therapy; D009894:Opportunistic Infections / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D001685:Biological Factors; D001688:Biological Products; C091592:biosporin