Visual hallucinosis: the major clinical determinant of distorted chromatic contour perception in Parkinson's disease.
Recently distorted chromatic contour perception has been demonstrated in Parkinson's disease (PD). The aim of our study is to determine the clinical factors which influence chromatic contour perception in PD. Chromatic and achromatic contour perception, colour discrimination and clinical data were evaluated in 73 patients with PD. We used a computer-aided method to determine the chromatic fusion time (CFT) which indicates the acuity of monochromatic contour perception. Chromatic CFT was generally shortened in patients as compared to controls (p < 0.01), whereas achromatic CFT was not significantly different. Variance analysis revealed the ability of colour discrimination and the risk of visual hallucinations as statistically significant (p < 0.05) variables influencing contour perception of certain stimuli. In contrast, disease stage, disease duration and disease severity have no relevant effect on chromatic contour perception in Parkinson's disease. On the basis of those properties one may suggest that distorted chromatic contour perception is due to an impairment at a central stage of visual processing in PD and an imbalance of the serotonergic system. Whether CFT is a reliable method to predict the individual risk of hallucinosis in PD has to be evaluated.
Büttner
T
T
Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Federal Republic of Germany.
Kuhn
W
W
Müller
T
T
Welter
F L
FL
Federlein
J
J
Heidbrink
K
K
Przuntek
H
H
D000368:Aged; D003118:Color Perception / Q000502:physiology*; D003936:Diagnosis, Computer-Assisted; D004192:Discrimination, Psychological / Q000502:physiology; D004298:Dopamine / Q000502:physiology; D005260:Female; D005425:Flicker Fusion / Q000502:physiology; D005556:Form Perception / Q000502:physiology*; D006212:Hallucinations / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology*; D011930:Reaction Time; D012701:Serotonin / Q000502:physiology; D012720:Severity of Illness Index; D014792:Visual Acuity; D014795:Visual Pathways / Q000378:metabolism / Q000503:physiopathology
D012701:Serotonin; D004298:Dopamine