[Induction of biological activities by chemically modified subfragments from human serum IgG and their application to development of medicine].
Immunoglobulin G (IgG) is an important protein in humoral immunity. After IgG binds to the specific foreign antigen, IgG-antigen complexes are eliminated either by making it easier for a phagocytic cell to ingest them or by activating a complement system. We found that the carboxyamidemethylated subfragments obtained from human serum IgG by reduction and alkylation of its interchain disulfide bonds, have anti-ulcerogenic, anti-inflammatory and anti-allergic activities, while no activity was recognized in the original IgG. On the other hand, some saturated and unsaturated fatty acids generally existing in microorganisms were found to have anti-inflammatory and anti-ulcerogenic activities. As the application of these researches, we synthesized hybrid compounds from sulfur-containing amines and fatty acids to make a lead compound for developing a new medicine. In this review, the experimental process will be discussed.
Mimura
T
T
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
D000478:Alkylation; D018926:Anti-Allergic Agents; D000893:Anti-Inflammatory Agents; D000897:Anti-Ulcer Agents; D000936:Antigen-Antibody Complex; D005227:Fatty Acids; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood
D018926:Anti-Allergic Agents; D000893:Anti-Inflammatory Agents; D000897:Anti-Ulcer Agents; D000936:Antigen-Antibody Complex; D005227:Fatty Acids; D007074:Immunoglobulin G