title: High-frequency oscillatory ventilation with partial liquid ventilation in a model of acute respiratory failure.
abstract: OBJECTIVE
  To determine whether there is an improvement in oxygenation when partial liquid ventilation and high-frequency oscillatory ventilation are combined in the treatment of acute lung injury, compared with high-frequency oscillatory ventilation alone.
  
  
  METHODS
  Controlled animal trial.
  
  
  METHODS
  Research laboratory in a university setting.
  
  
  METHODS
  Ten 3-kg piglets.
  
  
  METHODS
  Anesthetized piglets underwent high-frequency oscillatory ventilation, with mean airway pressure of 20 cm H2O, before induction of acute lung injury with repeated saline lavage. When PaO2 values were < 100 torr (< 13.3 kPa), five animals were randomized to receive escalating doses (3, 15, and 30 mL/kg) of perflubron at 60-min intervals. The other five animals remained on high-frequency oscillatory ventilation only. Sham dosing was performed at 60-min intervals in these animals. Arterial blood gases were obtained in both groups at baseline, after injury, and after perflubron and sham doses.
  
  
  RESULTS
  Statistically significant improvements in oxygenation were demonstrated in animals that received 3 mL/kg of perflubron with high-frequency oscillatory ventilation compared with animals receiving high-frequency oscillatory ventilation alone (253 +/- 161 vs. 90 +/- 30 torr [33.65 +/- 21.46 vs. 12.0 +/- 4.0 kPa], p < .05). Improvements in oxygenation with additional administration of perflubron were not greater than the improvements seen in the high-frequency oscillatory ventilation-only group. PaCO2 and pH were similar in both groups at all times. No hemodynamic compromise occurred in either group of animals.
  
  
  CONCLUSIONS
  The combination of low-dose perflubron with high-frequency oscillatory ventilation leads to more rapid improvement in arterial oxygenation than high-frequency oscillatory ventilation alone, in a piglet model of acute lung injury. Although the group receiving high-frequency oscillatory ventilation alone eventually achieved PaO2 values that were equivalent to the group receiving high-frequency ventilation and perflubron, the combination of perflubron with high-frequency oscillatory ventilation may permit effective oxygenation and ventilation at lower mean airway pressures by facilitating alveolar expansion and decreasing intrapulmonary shunt.
authors.affiliation: Department of Anesthesiology, University of Washington School of Medicine and Children's Hospital, Seattle, USA.
authors.forename: H P
authors.initials: HP
authors.lastname: Baden
authors.forename: J D
authors.initials: JD
authors.lastname: Mellema
authors.forename: S L
authors.initials: SL
authors.lastname: Bratton
authors.forename: P P
authors.initials: PP
authors.lastname: O'Rourke
authors.forename: J C
authors.initials: JC
authors.lastname: Jackson
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D001784:Blood Gas Analysis; D005466:Fluorocarbons / Q000627:therapeutic use*; D006612:High-Frequency Ventilation; D006842:Hydrocarbons, Brominated; D008954:Models, Biological; D012131:Respiratory Insufficiency / Q000628:therapy*; D013552:Swine
chemical_list: D019440:Anti-Obesity Agents; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; C003072:perflubron