title: Corino-Andrade disease (familial amyloidotic polineuropathy type I) in Spain: urological and andrological disorders.
abstract: In our hospital, we have followed a group of patients with familial amyloidotic polyneuropathy (FAP), type I. This disease is characterized by a progressive sensitive-motor and autonomic polyneuropathy. The amyloid fibrils of FAP I contain a mutant transthyretin (TTR) molecule. More than 90% of TTR production occurs in the liver. Thus, therapy with liver transplantation has proved useful. All our patients received this treatment. In this study we describe the urological and andrological disorders caused by FAP type I in 12 patients with low bladder pressure and bladder neck obstruction with micturition disorders. In some males, it was accompanied by impotence and retrograde ejaculation produced by autonomic neuropathy. We believe hepatic transplantation may be the best treatment for this disease.
authors.affiliation: Virgen de la Arrixaca University Urological Service, Clinical Hospital, Murcia, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Hita Villaplana
authors.forename: E
authors.initials: E
authors.lastname: Hita Rosino
authors.forename: P
authors.initials: P
authors.lastname: López Cubillana
authors.forename: L
authors.initials: L
authors.lastname: Asensio Egea
authors.forename: P
authors.initials: P
authors.lastname: Martínez Pertusa
authors.forename: M
authors.initials: M
authors.lastname: Pérez Albacete
mesh_terms: D000328:Adult; D017772:Amyloid Neuropathies / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005832:Genital Diseases, Male / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D016031:Liver Transplantation / Q000502:physiology; D008297:Male; D008875:Middle Aged; D013030:Spain / Q000453:epidemiology; D014570:Urologic Diseases / Q000503:physiopathology* / Q000601:surgery