CSF inositol does not predict antidepressant response to inositol. Short communication.
CSF inositol was reported to be reduced in depression and inositol has been reported to be effective in treatment of depression. We studied CSF inositol in 18 drug-free depressed patients and 36 normal controls; the depressed patients then participated in an open trial of 18 gm daily inositol treatment for 4 weeks. There was no difference in pre-treatment CSF inositol between depressed patients and controls. CSF inositol levels did not predict response on the Hamilton Depression Scale to 4 weeks of inositol treatment.
Levine
J
J
Ministry of Health Mental Health Center. Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel.
Kurtzman
L
L
Rapoport
A
A
Zimmerman
J
J
Bersudsky
Y
Y
Shapiro
J
J
Belmaker
R H
RH
Agam
G
G
D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000134:cerebrospinal fluid* / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy*; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007294:Inositol / Q000134:cerebrospinal fluid* / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011379:Prognosis
D000928:Antidepressive Agents; D007294:Inositol