No evidence for an allelic association between schizophrenia and markers D22S278 and D22S283.
We report a case control association study using markers D22S278 and D22S283 in 90 unrelated patients with DSMIII-R schizophrenia and 90 controls matched for ethnicity, age and sex. No differences between allele frequencies for either marker were observed when the two groups were compared (D22S278: chi 2 = 6.53, df = 7, P = 0.51; D22S283: chi 2 = 14.73, df = 15, P = 0.48). These findings fail to support previous work by others suggesting the presence of allelic association between the markers D22S278 and D22S283 and schizophrenia.
Williams
N M
NM
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK.
Jones
L A
LA
Murphy
K C
KC
Cardno
A G
AG
Asherson
P
P
Williams
J
J
McGuffin
P
P
Owen
M J
MJ
D000483:Alleles; D016022:Case-Control Studies; D002892:Chromosomes, Human, Pair 22; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012559:Schizophrenia / Q000235:genetics*
D005819:Genetic Markers