title: Phenobarbital induction of CYP6D1 is due to a trans acting factor on autosome 2 in house flies, Musca domestica.
abstract: To improve our understanding of phenobarbital (PB) mediated induction of CYP6D1 we examined the genetic linkage of PB induction using PB responsive (aabys) and non-responsive (LPR) strains of house flies. PB induction was linked to autosome 2, indicating that CYP6D1 is trans regulated by this PB inducible element. Our results are discussed relative to a previous hypothesis that the same regulatory genes are responsible for both induction and monooxygenase-mediated insecticide resistance.
authors.affiliation: Department of Entomology, Cornell University, Ithaca, New York 14853-0901, USA.
authors.forename: N
authors.initials: N
authors.lastname: Liu
authors.forename: J G
authors.initials: JG
authors.lastname: Scott
mesh_terms: D000818:Animals; D015152:Blotting, Northern; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D000072472:Cytochrome P450 Family 6; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D006793:Houseflies / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D019476:Insect Proteins; D010634:Phenobarbital / Q000494:pharmacology*; D015533:Transcriptional Activation
chemical_list: D019476:Insect Proteins; D003577:Cytochrome P-450 Enzyme System; C092307:CYP6D1 protein, Musca domestica; D000072472:Cytochrome P450 Family 6; D010634:Phenobarbital