title: Evaluation of the efficacy of a 3.2% glutaraldehyde product for disinfection of fibreoptic endoscopes with an automatic machine.
abstract: The efficacy of 'Cidex Plus' 3.2% alkaline glutaraldehyde was evaluated for the disinfection of fibreoptic endoscopes. The glutaraldehyde concentration in 'Cidex Plus', stored in an automatic machine (Olympus EW-20), remained higher than 2% (2.21%) even after a total of 102 disinfection cycles during 28 consecutive days. The results of the in-vitro study on antimicrobial activity showed that this alkaline glutaraldehyde product had a greater activity against 20 test organisms, including vegetative bacteria, bacterial spores, mycobacteria, and fungi, than 2% glutaraldehyde alone. The presence of 10 or 30% human serum did not appear to affect the activity of glutaraldehyde adversely. Instrument samples made from a variety of materials such as stainless steel, glass, teflon, etc. were not damaged after 168 h of immersion in alkaline glutaraldehyde, although it contained approximately 1.7 times more glutaraldehyde than 2% glutaraldehyde alone. Based on these results, 3.2% alkaline glutaraldehyde is considered to be a more effective disinfectant for fibreoptic endoscopes, with the use of an automatic machine, than 2% glutaraldehyde.
authors.affiliation: Department of Pharmacy, Kyushu Kousei-Nenkin Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Akamatsu
authors.forename: K
authors.initials: K
authors.lastname: Tabata
authors.forename: M
authors.initials: M
authors.lastname: Hironaga
authors.forename: M
authors.initials: M
authors.lastname: Uyeda
mesh_terms: D002626:Chemistry, Pharmaceutical; D004203:Disinfection / Q000295:instrumentation* / Q000379:methods*; D004353:Drug Evaluation, Preclinical; D019723:Endoscopes; D004866:Equipment Contamination / Q000517:prevention & control*; D005336:Fiber Optic Technology / Q000295:instrumentation*; D005976:Glutaral / Q000737:chemistry / Q000592:standards*; D006801:Humans
chemical_list: D005976:Glutaral