title: Transdermally administered nicotine accumulates in gastric juice.
abstract: METHODS
  Transdermal nicotine patches (Nicorette 15 mg.16 h-1) were administered to 7 healthy volunteers. Nicotine concentrations in gastric juice were monitored for 8 h via a naso-gastric tube and so was nicotine in saliva and plasma.
  
  
  RESULTS
  Nicotine accumulated in gastric juice, the average concentration being 60.6-times higher than in plasma. In saliva, too, the concentration was higher than in plasma, the average ratio being 10.5. These results strongly suggested ion-trapping of nicotine base in the acidic gastric juice and possibly also in the acinar cells, followed by active secretion. It is hypothesised that accumulation in saliva occurs via a similar mechanism. Pretreatment with omeprazole did not increase the pH to a sufficiently high degree to test the hypothesis that the accumulation of nicotine in gastric juice was pH dependent.
  
  
  CONCLUSIONS
  Transdermal administration of nicotine produced a high intragastric concentration. The clinical consequence of this effect of long-term nicotine replacement therapy during smoking cessation is unclear.
authors.affiliation: Department of Surgery, University Hospital Lund, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Lindell
authors.forename: E
authors.initials: E
authors.lastname: Lunell
authors.forename: H
authors.initials: H
authors.lastname: Graffner
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D005260:Female; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012463:Saliva / Q000378:metabolism
chemical_list: D009538:Nicotine