How Ras-related proteins talk to their effectors.
More and more effectors for the Ras-related protein superfamily are being discovered and it is emerging that these GTP-binding proteins interact with more than one effector to generate more than one cellular signal. Atomic details for the interaction of Rap/Ras with one of the effectors, the protein kinase c-Raf-1, have recently become available by X-ray structure analysis. The implications for the specificity of the signal transduction pathway, and how the GTP-dependent switch mechanism modulates the interaction with effectors will be discussed here, using Ras as a paradigm.
Wittinghofer
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Max-Planck-Institut für Molekulare Physiologie, Dortmund, Germany. Alfred.Wittinghofer@mpi-dortmund.mpg.de
Nassar
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D000818:Animals; D001665:Binding Sites; D019204:GTP-Binding Proteins / Q000737:chemistry* / Q000145:classification / Q000378:metabolism*; D006153:Guanosine Diphosphate / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D008958:Models, Molecular; D009711:Nucleotides / Q000378:metabolism; D011487:Protein Conformation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D019908:Proto-Oncogene Proteins c-raf; D018631:ras Proteins / Q000737:chemistry* / Q000145:classification / Q000378:metabolism*
D009711:Nucleotides; D011518:Proto-Oncogene Proteins; D006153:Guanosine Diphosphate; D006160:Guanosine Triphosphate; D017346:Protein Serine-Threonine Kinases; D019908:Proto-Oncogene Proteins c-raf; D019204:GTP-Binding Proteins; D018631:ras Proteins