title: Effects of diabetes on methamphetamine-induced place preference in mice.
abstract: The effects of diabetes on methamphetamine-induced place preference in mice were examined. Methamphetamine caused a dose-dependent place preference in both diabetic and non-diabetic mice. Methamphetamine preferentially induced place preference in diabetic mice as compared to those in non-diabetic mice. Indeed, methamphetamine-induced place preference at a dose of 0.3 mg/kg in diabetic mice was similar to that at 3 mg/kg in non-diabetic mice. Furthermore, methamphetamine-induced place preference in both diabetic and non-diabetic mice was significantly antagonized by pretreatment with quinpirole, a dopamine D2/D3 receptor agonist. Methamphetamine-induced place preference was also antagonized by pretreatment with 7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT), a selective dopamine D3 receptor agonist. On the other hand, 7-OH-DPAT produced significant place aversion in non-diabetic mice. 7-OH-DPAT produced neither place preference nor place aversion in diabetic mice. These results suggest that methamphetamine-induced place preference may be modulated by dopamine D3 receptors. Furthermore, increased dopamine neurotransmission associated with the down-regulation of presynaptic dopamine D3 receptor-mediated functions may account for the enhancement of methamphetamine's reinforcing effect in diabetic mice.
authors.affiliation: Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Kamei
authors.forename: M
authors.initials: M
authors.lastname: Ohsawa
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000523:psychology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D009714:Nucleus Accumbens / Q000187:drug effects / Q000502:physiology; D019257:Quinpirole / Q000494:pharmacology; D017448:Receptors, Dopamine D2 / Q000502:physiology; D050637:Receptors, Dopamine D3; D012054:Reinforcement, Psychology; D013311:Streptozocin; D013764:Tetrahydronaphthalenes / Q000494:pharmacology
chemical_list: C493594:Drd3 protein, mouse; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D013764:Tetrahydronaphthalenes; D019257:Quinpirole; D008694:Methamphetamine; D013311:Streptozocin; C031349:7-hydroxy-2-N,N-dipropylaminotetralin