title: Guillain-Barré syndrome and ethylene diamine tetraacetic acid-dependent pseudothrombocytopenia associated with mumps.
abstract: A 35-year-old man with Guillain-Barré syndrome and ethylene diamine tetraacetic acid (EDTA)-dependent pseudothrombocytopenia associated with serologically-confirmed mumps is presented. A polyneuropathy developed 18 days after the onset of mumps, that improved with plasmapheresis. A decreased platelet count was observed 25 days after the onset of mumps attributed to platelet agglutination in blood anticoagulated with EDTA, and the agglutination was prevented by other anticoagulants. Guillain-Barré syndrome associated with mumps is rare and EDTA-dependent pseudothrombocytopenia following mumps has never been documented. This represents the first report of Guillain-Barré syndrome and EDTA-dependent pseudothrombocytopenia following mumps. Furthermore, our findings suggest activation of the humoral immune response as a potential pathogenesis.
authors.affiliation: Department of Internal Medicine, Inami Municipal General Hospital, Toyama.
authors.forename: A
authors.initials: A
authors.lastname: Sawazaki
authors.forename: N
authors.initials: N
authors.lastname: Nakamura
authors.forename: H
authors.initials: H
authors.lastname: Jyokaji
authors.forename: S
authors.initials: S
authors.lastname: Minami
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Matsuda
mesh_terms: D000328:Adult; D004492:Edetic Acid; D006801:Humans; D008297:Male; D009107:Mumps / Q000150:complications*; D011129:Polyradiculoneuropathy / Q000209:etiology*; D013921:Thrombocytopenia / Q000209:etiology*
chemical_list: D004492:Edetic Acid