title: Pyridinium cross-links in multiple myeloma: correlation with clinical parameters and use for monitoring of intravenous clodronate therapy--a pilot study of the German Myeloma Treatment Group (GMTG).
abstract: The relevance of quantitative determinations of urinary deoxypyridinolines (DPY) and pyridinolines (PY), and of serum type I collagen carboxyterminal cross-linked telopeptides (ICTP), has been evaluated for patient monitoring in multiple myeloma (MM). In 178 untreated MM patients, a clear correlation was found between ICTP concentrations, bone destructions and serum calcium levels. Furthermore, serum ICTP, urinary DPY and PY concentrations were estimated before and during treatment in a further 33 MM patients randomly allocated to four groups receiving intravenous melphalan/prednisone (MivP) chemotherapy alone, or MivP in combination with three different doses of i.v. clodronate. 1800 mg of i.v. clodronate combined monthly with MivP induced a rapid and sustained reduction in bone resorption parameters to the normal range, a result not obtained with either MivP alone, or with a lower clodronate dose. While confirming the relevance of determining pyridinium cross-links for estimating bone resorption in MM, our data indicate that measurements of these parameters could be useful for dose finding and monitoring of bisphosphonate therapy.
authors.affiliation: Abt. Klinische Immunologie, Medizinische Hochschule Hannover, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Peest
authors.forename: H
authors.initials: H
authors.lastname: Deicher
authors.forename: W
authors.initials: W
authors.lastname: Fett
authors.forename: P
authors.initials: P
authors.lastname: Harms
authors.forename: H J
authors.initials: HJ
authors.lastname: Braun
authors.forename: M
authors.initials: M
authors.lastname: Planker
authors.forename: U
authors.initials: U
authors.lastname: Kindler
authors.forename: C
authors.initials: C
authors.lastname: Klinkenstein
authors.forename: E
authors.initials: E
authors.lastname: Schäfer
authors.forename: K
authors.initials: K
authors.lastname: Schumacher
authors.forename: H
authors.initials: H
authors.lastname: Siecke
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000596:Amino Acids / Q000378:metabolism* / Q000652:urine; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001862:Bone Resorption / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D004002:Clodronic Acid / Q000627:therapeutic use; D003094:Collagen / Q000097:blood; D024042:Collagen Type I; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000473:pathology; D009367:Neoplasm Staging; D010257:Paraneoplastic Syndromes / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D010455:Peptides / Q000097:blood; D010865:Pilot Projects
chemical_list: D000596:Amino Acids; D014408:Biomarkers, Tumor; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D004002:Clodronic Acid; C015484:pyridinoline; C036020:deoxypyridinoline; D003094:Collagen