Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases.
Bafilomycins and concanamycins, two groups of the plecomacrolide-defined class of macrolide antibiotics, have recently been recognized as important tools for studying the physiological role of vacuolar-type, proton-translocating ATPases (V-ATPases) and ATPases with phosphorylated states (P-ATPases) in animal and plant cells as well as in yeast, fungi and bacteria. The following review will give an account of the classification and function of these antibiotics.
Dröse
S
S
Universität Osnabrück, Fachbereich Biologie/Chemie, Germany.
Altendorf
K
K
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001693:Biological Transport, Active / Q000187:drug effects; D004791:Enzyme Inhibitors; D005656:Fungal Proteins / Q000037:antagonists & inhibitors; D006801:Humans; D006863:Hydrogen-Ion Concentration; D018942:Macrolides; D010766:Phosphorylation; D006180:Proton-Translocating ATPases / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D025262:Vacuolar Proton-Translocating ATPases
D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D005656:Fungal Proteins; D018942:Macrolides; C057620:bafilomycin A; C036978:concanamycin A; D000251:Adenosine Triphosphatases; D025262:Vacuolar Proton-Translocating ATPases; D006180:Proton-Translocating ATPases