The effect of lethal doses of radiation in vivo on the lipid microviscosity of tumor nuclear membranes.
The changes in the microviscosity of the nuclear membranes of tumor and liver cells of tumor hosts with developing Erlich ascites carcinoma at different times after irradiation of lethal dose has been studied by spin probe method. Using two iminoxyl radicals localized in various lipid regions, it was shown that the character and degree of changes in microviscosity, estimated from rotational correlation time for spin probes, indicate the different response to irradiation of liver and tumor cells.
Mal'tseva
E L
EL
Russian Academy of Sciences, Institute of Biochemical Physics, Moscow, Russia.
Pal'mina
N P
NP
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods; D005609:Free Radicals / Q000032:analysis / Q000378:metabolism / Q000528:radiation effects; D008099:Liver / Q000378:metabolism / Q000528:radiation effects; D008560:Membrane Fluidity / Q000528:radiation effects*; D008563:Membrane Lipids / Q000378:metabolism / Q000528:radiation effects*; D051379:Mice; D009685:Nuclear Envelope / Q000378:metabolism / Q000528:radiation effects*; D013113:Spin Labels; D014783:Viscosity
D005609:Free Radicals; D008563:Membrane Lipids; D013113:Spin Labels