[Drug-induced pneumopathies accompanied by acute respiratory insufficiency].
Drug induced pneumonias accompanying acute respiratory failure are defined by a delay in presentation of less two months and severe hypoxaemia (PaO2 < 60 mmHg in ambient air). They are poorly indexed, often poorly understood by the clinician and pose difficult problems both of diagnosis and treatment. This general review touches successively on hypoxaemic drug induced pneumonia observed in oncology and haematology then those observed outside this very specific context. In each of the two groups five questions are posed: 1) Which patients? 2) Which clinical patterns? 3) What initial diagnostic discussion? 4) Which successful elements support the drug induced hypothesis? 5) What outcome? The replies obtained were compared to case reports from the literature (188 references) or from recent general reviews concerned more specifically with the hypoxaemic forms.
Mayaud
C
C
Centre de Pneumologie et de Réanimation Respiratorie, Hôpital Tenon, Paris.
Mangiapan
G
G
De Groote
E
E
Parrot
A
A
Cadranel
J
J
Milleron
B
B
D000208:Acute Disease; D000970:Antineoplastic Agents / Q000009:adverse effects; D003937:Diagnosis, Differential; D064420:Drug-Related Side Effects and Adverse Reactions; D006402:Hematologic Diseases / Q000188:drug therapy; D006801:Humans; D000860:Hypoxia / Q000139:chemically induced / Q000503:physiopathology; D008171:Lung Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D009369:Neoplasms / Q000188:drug therapy; D012131:Respiratory Insufficiency / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D016896:Treatment Outcome
D000970:Antineoplastic Agents