The role of HIV1 Nef in T-cell activation: Nef impairs induction of Th1 cytokines and interacts with the Src family tyrosine kinase Lck.
Collette
Y
Y
INSERM U119, Marseille, France.
Dutartre
H
H
Benziane
A
A
Olive
D
D
D000818:Animals; D016207:Cytokines / Q000096:biosynthesis*; D015693:Gene Products, nef / Q000502:physiology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck); D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology* / Q000821:virology; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology; D018808:Transcription Factor AP-1 / Q000378:metabolism; D054311:nef Gene Products, Human Immunodeficiency Virus; D019061:src-Family Kinases / Q000378:metabolism*
D016207:Cytokines; D015693:Gene Products, nef; D007376:Interleukin-2; D011948:Receptors, Antigen, T-Cell; D018808:Transcription Factor AP-1; D054311:nef Gene Products, Human Immunodeficiency Virus; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck); D019061:src-Family Kinases