title: Radiolabelled-tyrosine for the measurement of protein synthesis rate in vivo by positron emission tomography.
abstract: The amino acid incorporation rate, generally described as protein synthesis rate or PSR, can be assessed in vivo using carboxylic-labelled amino acids such as L-[1-11C]tyrosine and PET. In animals, labelled tissue metabolites are below 4% of total tissue radioactivity and are therefore neglected in the model. Labelled plasma metabolites on the other hand rise continuously to 50% of total plasma radioactivity at 40 minutes. After correction of the total plasma radioactivity for the metabolite fraction, a Patlak analysis may be performed to calculate the PSR. A number of applications in the field of oncology were presented. The use of L-[1-11C]tyrosine in the study of metabolic disease was also discussed. It is concluded that the application of [11C]tyrosine-PET in a clinical setting is of interest for an increasing number of diseases.
authors.affiliation: PET Center, Groningen University Hospital, The Netherlands.
authors.forename: A M
authors.initials: AM
authors.lastname: Paans
authors.forename: J
authors.initials: J
authors.lastname: Pruim
authors.forename: A
authors.initials: A
authors.lastname: van Waarde
authors.forename: A T
authors.initials: AT
authors.lastname: Willemsen
authors.forename: W
authors.initials: W
authors.lastname: Vaalburg
mesh_terms: D000818:Animals; D002250:Carbon Radioisotopes; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism; D014055:Tomography, Emission-Computed / Q000379:methods*; D014443:Tyrosine / Q000032:analysis / Q000378:metabolism*
chemical_list: D002250:Carbon Radioisotopes; D011506:Proteins; D014443:Tyrosine