Cripto expression in human urological tumors.
The expression of cripto, a novel transforming gene of the epidermal growth factor superfamily, was immunohistochemically examined in 20 cases of urinary bladder, one ureter, three renal pelvic, 18 kidney, nine prostate, three adrenal and four testicular tumors. Three cases of urinary bladder carcinomas, two of grade 2 and one of grade 3 transitional cell carcinoma which were T1a and T3b, and INF beta and INF gamma, respectively, showed positive binding of specific antibody, along with one cortical carcinoma of the adrenal gland positive staining. None of the ureter, renal pelvic, kidney, prostate or testicular tumors showed positive staining. These results indicate that cripto is not frequently expressed in urological tumors.
Okajima
E
E
Department of Oncological Pathology, Cancer Center, Nara Medical University, Shijyo-cho, Kashihara, Japan.
Tsutsumi
M
M
Okajima
E
E
Konishi
Y
Y
D000310:Adrenal Gland Neoplasms / Q000737:chemistry; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D002295:Carcinoma, Transitional Cell / Q000737:chemistry*; D004815:Epidermal Growth Factor; D005260:Female; D058851:GPI-Linked Proteins; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008562:Membrane Glycoproteins; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis* / Q000235:genetics; D011471:Prostatic Neoplasms / Q000737:chemistry; D013736:Testicular Neoplasms / Q000737:chemistry; D014571:Urologic Neoplasms / Q000737:chemistry*
D014408:Biomarkers, Tumor; D058851:GPI-Linked Proteins; D036341:Intercellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; C070636:TDGF1 protein, human; D004815:Epidermal Growth Factor