Diets deficient in selenium and vitamin E affect plasma lipoprotein and apolipoprotein concentrations in the rat.
The present study examined the effects of Se, vitamin E and combined Se and vitamin E deficiencies in rats on plasma lipid, lipoprotein and apolipoprotein (apo) concentrations. Deficiencies were induced by feeding rats the respective diets for 6 weeks. The study shows that Se deficiency results in increased concentrations of plasma cholesterol and apo E. Both could be explained by an increase in the HDL1 fraction. Vitamin E deficiency alone had no significant effect on plasma lipid, lipoprotein and apo concentrations. Se deficiency in combination with vitamin E deficiency leads to an increase in plasma LDL and apo B concentrations. These results point to the need for further investigations on the mechanism by which Se deficiency affects lipoprotein metabolism.
Mazur
A
A
Centre de Recherche en Nutrition Humaine de Clermont-Ferrand, Unité Maladies Métaboliques et Micronutriments, INRA, Theix, Saint-Genès-Champanelle, France.
Nassir
F
F
Gueux
E
E
Moundras
C
C
Bellanger
J
J
Grolier
P
P
Rock
E
E
Rayssiguier
Y
Y
D000818:Animals; D001053:Apolipoproteins / Q000097:blood; D001057:Apolipoproteins E / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000172:deficiency*; D014811:Vitamin E Deficiency / Q000097:blood*
D001053:Apolipoproteins; D001057:Apolipoproteins E; D008074:Lipoproteins; D002784:Cholesterol; D012643:Selenium