TJS-010, a new prescription of oriental medicine, enhances 8-OH-DPAT-induced effects in rats.
We evaluated the effect of TJS-010, a new prescription of oriental medicine, on hypothermia and flat body posture in rats, induced by activation of serotonin (5-HT)-1A receptors by (+/-)-8-hydroxy-2-(di-N-propylamino)-tetralin (8-OH-DPAT). Hypothermia was induced by 8-OH-DPAT in a dose and time-dependent manner. The hypothermia induced by 0.1 mg/kg 8-OH-DPAT was enhanced by 500 and 750 mg/kg of TJS-010. At the concentration of 0.1 mg/kg, 8-OH-DPAT also produced flat body posture in rats, and 750 mg/kg TJS-010 increased the flat body posture. These results suggest that TJS-010 facilitates the 5-HT-1A receptors in the central nervous system.
Kagaya
A
A
Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Japan.
Tanra
A J
AJ
Shinno
H
H
Kugaya
A
A
Muraoka
M
M
Oyamada
T
T
Uchitomi
Y
Y
Yamawaki
S
S
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D011187:Posture / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D010936:Plant Extracts; D017366:Serotonin Receptor Agonists; C103811:TJS 010; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin