title: Fetal distress due to placental insufficiency at 26 through 31 weeks: a comparison between an active and a more conservative management.
abstract: OBJECTIVE
  To compare perinatal mortality and short-term morbidity in extremely preterm infants with fetal distress due to placental insufficiency in two centers with different management attitude.
  
  
  METHODS
  Retrospective cohort study in two university hospitals of all infants with fetal growth retardation due to placental insufficiency resulting in signs of fetal distress at 26 through 31 weeks gestational age, during the years 1984 through 1989. Center A followed a conservative management: in some cases the risk of major handicaps or mortality was estimated so high, based on antenatally estimated fetal weight and gestational age, that the decision was taken to abstain from treatment. In all other cases cesarean section took place, but only if fetal distress was obvious. Center B used a more active management: cesarean section was performed in all cases, sometimes with only minor changes in fetal heart rate variability.
  
  
  RESULTS
  Overall survival differed significantly: 55% (center A) versus 72% (center B), largely due to antenatal mortality in center A. Discharge survival rate of liveborn infants was 81% in center A and 72% in center B. More than half of the postnatal mortality was attributed to respiratory causes in both centres. An active management showed a tendency to a higher incidence of short-term morbidity.
  
  
  CONCLUSIONS
  Selection by antenatal prediction of postnatal mortality using estimated fetal weight fails. Even in the group with the lowest birthweight postnatal mortality did not surpass 50%. Early intervention may be associated with higher short-term morbidity. Long-term follow-up of these children is needed to discriminate between both policies with regard to further development of surviving infants.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Amsterdam, Netherlands.
authors.forename: A H
authors.initials: AH
authors.lastname: Schaap
authors.forename: H
authors.initials: H
authors.lastname: Wolf
authors.forename: H W
authors.initials: HW
authors.lastname: Bruinse
authors.forename: R
authors.initials: R
authors.lastname: de Leeuw
authors.forename: I
authors.initials: I
authors.lastname: van Ertbruggen
authors.forename: P E
authors.initials: PE
authors.lastname: Treffers
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology; D002585:Cesarean Section; D015331:Cohort Studies; D005260:Female; D005316:Fetal Distress / Q000209:etiology* / Q000401:mortality / Q000628:therapy*; D005317:Fetal Growth Retardation / Q000209:etiology* / Q000628:therapy; D005865:Gestational Age; D006785:Hospitals, University; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D010927:Placental Insufficiency / Q000150:complications*; D011247:Pregnancy; D012121:Respiration, Artificial; D012127:Respiratory Distress Syndrome, Newborn / Q000453:epidemiology; D012189:Retrospective Studies; D015996:Survival Rate