[Changes in the energy metabolism in the kidneys of white rats in the dynamics of acute sodium nitrate poisoning].
Experimental study of white rats has shown that the intragastric introduction of sodium nitrate at a rate of 9.6 g/kg of their mass is followed by the development of considerable disturbances of energy metabolism in kidneys. It was shown that the depression and separation of oxidation and phosphorylation, decrease energetic potential in the kidney tissues. The results obtained permit supposing the significant role of nitric oxide in kidneys as a factor resulting in bioenergetic disturbances. Maximum maintenance of Fe-NO complexes was marked 24 hours after the introduction of sodium nitrate and it corresponded to maximum disturbances of energy metabolism.
Kostenko
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D000208:Acute Disease; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D004734:Energy Metabolism / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D009566:Nitrates / Q000506:poisoning*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D011041:Poisoning / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D002273:Carcinogens; D009566:Nitrates; C031618:sodium nitrate