Kallikrein-kinin system in patients with neoplastic diseases.
The concentrations of kininogens, prokallikrein, fibrinogen, plasma protein, proteinase inhibitor antigens, and the kininase, fibrinolytic and antipapain activities in plasma of 29 patients with various tumours (lung cancers, lymphomas, and others) during chemotherapy were measured. The same studies were performed on blood plasma of female patients operated on because of cervical or endometrial carcinoma (37 subjects) and submitted to subsequent local radiotherapy (before and after radiotherapy). A weak activation of kallikrein-kinin system and significant decrease in kininase and fibrinolytic activities were found in those patients. It may suggest a role of bradykinin in prevention of therapy-induced hypercoagulability in patients with neoplastic diseases.
Czokało
M
M
Department of General and Experimental Pathology, Medical Academy of Białystok.
Pałka
M
M
Kralisz
P
P
Filipkowski
T
T
D000328:Adult; D001920:Bradykinin / Q000502:physiology; D003131:Combined Modality Therapy; D005260:Female; D005342:Fibrinolysis / Q000502:physiology; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D016234:Kallikrein-Kinin System / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000503:physiopathology* / Q000628:therapy*
D001920:Bradykinin