Mapping a gene for adult-onset primary open-angle glaucoma to chromosome 3q.
Glaucoma is the third-leading cause of blindness in the world, affecting >13.5 million people. Adult-onset primary open-angle glaucoma (POAG) is the most common form of glaucoma in the United States. We present a family in which adult-onset POAG is inherited as an autosomal dominant trait. Twelve affected family members were identified from 44 at-risk individuals. The disease-causing gene was mapped to chromosome 3q21-24, with analysis of recombinant haplotypes suggesting a total inclusion region of 11.1 cM between markers D3S3637 and D3S1744. This is the first report of mapping of an adult-onset POAG gene to chromosome 3q, gene symbol GLC1C.
Wirtz
M K
MK
Department of Ophthalmology, Oregon Health Sciences University, Portland 97201-4197, USA.
Samples
J R
JR
Kramer
P L
PL
Rust
K
K
Topinka
J R
JR
Yount
J
J
Koler
R D
RD
Acott
T S
TS
D000328:Adult; D000368:Aged; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D005902:Glaucoma, Open-Angle / Q000235:genetics*; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D010375:Pedigree