Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer.
Tumor specimens from 109 patients with previously untreated squamous cell lung carcinomas were analyzed immunohistologically for the expression of vascular endothelial growth factor (VEGF) and its receptor Flt-1. Our analysis attempted to determine whether these factors have additional prognostic value for the patients' survival. VEGF staining was seen in 59% and Flt-1 staining in 68% of the cases. No significant correlations were detected between VEGF or Flt-1 expression and stage or metastasis. Patients with VEGF-stained tumors had significantly lower survival times than patients with negative tumors. Expression of Flt-1 showed no significant correlation with survival. Combining VEGF and Flt-1 expressions did not improve the prognostic value. Multivariate analysis showed that metastasis and VEGF expression are significant and independent prognostic factors for the survival of patients with squamous cell lung carcinomas.
Volm
M
M
German Cancer Research Center, Department of Oncological Diagnostics and Therapy, Heidelberg, Germany.
Koomägi
R
R
Mattern
J
J
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D016228:Endothelial Growth Factors / Q000032:analysis*; D005260:Female; D006801:Humans; D015993:Life Tables; D008175:Lung Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D008222:Lymphokines / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D020794:Receptor Protein-Tyrosine Kinases / Q000032:analysis*; D017978:Receptors, Growth Factor / Q000032:analysis; D015996:Survival Rate; D013997:Time Factors; D042461:Vascular Endothelial Growth Factor A; D040281:Vascular Endothelial Growth Factor Receptor-1; D042442:Vascular Endothelial Growth Factors
D014408:Biomarkers, Tumor; D016228:Endothelial Growth Factors; D008222:Lymphokines; D011518:Proto-Oncogene Proteins; D017978:Receptors, Growth Factor; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D020794:Receptor Protein-Tyrosine Kinases; D040281:Vascular Endothelial Growth Factor Receptor-1