[Relation between the conformation and antioxidant properties in a series of topochemical analogs of carnosine and carcinine with different N-acyl substitutes].
To elucidate the influence of the nature of N-acyl substituent on antioxidant properties of carcinine analogs, the corresponding histamine derivatives were synthesized. Antioxidant activity of the compounds prepared was investigated in the Fe(2+)-ascorbate-dependent system of oxidation of the linoleic acid micellar solution. Conformations of carnosine, carcinine, and their analogs were calculated by the molecular mechanics MM+ method. The structural elements and conformations that are preferable for the appearance of antioxidant activity were found.
Rozhkova
E A
EA
Ogrel'
S A
SA
Grigor'ev
D N
DN
Nebol'sin
V E
VE
Zheltukhina
G A
GA
Evstigneeva
R P
RP
D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D002336:Carnosine / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D008958:Models, Molecular; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
D000975:Antioxidants; D002336:Carnosine; C015055:carcinine