[Contrast medium supported imaging of tumorous vessels by color Doppler and power Doppler mode in animal experiments].
OBJECTIVE
The purpose was to determine tumor neovascularisation via colour-coded Doppler (duplex) sonography and the "power mode", both visually and quantitatively, by means of videodensitometry.


METHODS
6 VX2 tumours of 4 to 11 mm size were implanted in 4 rabbits at various sites. The colour-coded duplex sonography and the new sonographic power technique were tested before and after having injected a new contrast medium (SH U 616A).


RESULTS
If no contrast medium was injected, tumour neovascularisation was identified in only 50% of the cases. Injection of contrast medium increased signal intensity three to fourfold with all examined tumors. Combined use of the sonographic method by the power technique with injection of contrast medium is outstandingly suitable for tumor vessel imaging even of small tumors, as these initial results seem to show.


CONCLUSIONS
If these results are corroborated by further studies, contrast-medium supported sonographic technique may possibly become established as an alternative method to other imaging procedures.
Graubner
T
T
Institut für Diagnostische und Interventionelle Radiologie, Klinikum, Friedrich-Schiller-Universität Jena.
Fritzsch
T
T
Hauff
P
P
Kaiser
W A
WA
D000273:Adipose Tissue / Q000000981:diagnostic imaging; D000818:Animals; D003287:Contrast Media; D003720:Densitometry; D009374:Neoplasms, Experimental / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging*; D011134:Polysaccharides; D011817:Rabbits; D018608:Ultrasonography, Doppler; D018615:Ultrasonography, Doppler, Color; D014741:Video Recording
D003287:Contrast Media; D011134:Polysaccharides; C059891:SHU 508