Region specific mitochondrial gene expression in the human retina.
The human mitochondrial genome has not been previously known to differentially express specific mRNA transcripts. Results of northern analysis, using total RNA from two different retinal regions, demonstrate that there is differential expression of five mitochondrial genes. There is a correlation of regional expression of one of these differentially expressed genes with the gene responsible for the majority of cases of foveo-macular mitochondropathy. These findings suggest that there is selective control over specific mitochondrial messenger steady state levels.
Bernstein
S L
SL
Department of Ophthalmology, University of Maryland, Baltimore 21201-1595, USA.
Borst
D E
DE
Wong
P
P
D015152:Blotting, Northern; D015342:DNA Probes; D004272:DNA, Mitochondrial / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D008928:Mitochondria / Q000737:chemistry / Q000201:enzymology; D008969:Molecular Sequence Data; D009243:NAD / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D017949:Retinal Cone Photoreceptor Cells / Q000502:physiology* / Q000648:ultrastructure; D014764:Viral Proteins / Q000235:genetics
C070354:Cox protein, Enterobacteria phage P2; D015342:DNA Probes; D004272:DNA, Mitochondrial; D004268:DNA-Binding Proteins; D007527:Isoenzymes; D012333:RNA, Messenger; D014764:Viral Proteins; D009243:NAD