Congenital absence of the uterus and vagina is not commonly transmitted as a dominant genetic trait: outcomes of surrogate pregnancies.
OBJECTIVE
To determine the inheritance pattern of congenital absence of the uterus and vagina in affected women undergoing surrogacy IVF with this disorder.


METHODS
Retrospective study.


METHODS
A hospital-based reproductive endocrinology and infertility center.


METHODS
Women diagnosed with congenital absence of the uterus and vagina undergoing IVF with subsequent transfer of embryos to a surrogate uterus.


METHODS
Questionnaires were sent to all infertility treatment centers performing surrogate procedures.


METHODS
Number, gender, and frequency of congenital anomalies in progeny.


RESULTS
Thirty-two of 53 surveyed programs responded (60%). One hundred sixty-two IVF cycles were performed, and 34 liveborn children were delivered (half female). No congenital anomalies were found, except for one male child with a middle ear defect and hearing loss.


CONCLUSIONS
These results strongly suggest that congenital absence of the uterus and vagina, if genetically transmitted, is not inherited commonly in a dominant fashion.
Petrozza
J C
JC
Department of Obstetrics and Gynecology, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts 02111, USA.
Gray
M R
MR
Davis
A J
AJ
Reindollar
R H
RH
D000013:Congenital Abnormalities / Q000235:genetics; D004432:Ear, Middle / Q000002:abnormalities; D005260:Female; D005307:Fertilization in Vitro; D005799:Genes, Dominant; D006311:Hearing Disorders / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D013533:Gestational Carriers; D014599:Uterus / Q000002:abnormalities*; D014621:Vagina / Q000002:abnormalities*