title: Natural killer cell receptors and MHC class I interactions.
abstract: Natural killer cells express two distinct families of genes encoding receptors for polymorphic MHC class I molecules. Recent advances indicate that immunoreceptor tyrosine-based inhibitory motifs in the cytoplasmic domains of the killer cell inhibitory receptors and Ly-49 receptors recruit the SH2-containing protein tyrosine phosphatases, SHP-1 and SHP-2, resulting in inhibition of natural-killer- and T-cell-mediated cytotoxicity and cytokine secretion.
authors.affiliation: DNAX Research Institute of Molecular and Cellular Biology, Department of Human Immunology, 901 California Avenue, Palo Alto, CA 94304-1104, USA. lanier@dnax.org
authors.forename: L L
authors.initials: LL
authors.lastname: Lanier
mesh_terms: D000818:Animals; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D007694:Killer Cells, Natural / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000378:metabolism*
chemical_list: D015395:Histocompatibility Antigens Class I; D011971:Receptors, Immunologic