title: Schwann cell invasion of the central nervous system of the myelin mutants.
abstract: Schwann cells are excluded from the CNS during development by the glial limiting membrane, an area of astrocytic specialisation present at the nerve root transitional zone, and at blood vessels in the neuropil. This barrier, however, can be disrupted and, with the highly migratory nature of Schwann cells, can result in their invasion and myelination of the CNS in many pathological situations. In this paper we demonstrate that this occurs in a number of myelin mutants, including the myelin deficient (md) and taiep rats and the canine shaking (sh) pup. While it is still relatively uncommon in the rodent mutants, the sh pup shows extensive Schwann cell invasion along the neuraxis. This invasion involves the spinal cord, brain stem, and cerebellum and increases in amount and distribution with age. In situ hybridisation studies using a Pzero riboprobe suggest that the likely origin of these cells in the sh pup is the nerve roots, primarily the dorsal roots. Paradoxically, Schwann cell myelination of the CNS increases with time in the sh pup despite a marked, progressive gliosis involving the glia limitans and neuropil. Thus the mechanism by which these cells migrate into the CNS through the gliosed nerve root transitional zone or from vasa nervorum remains unknown. Extensive Schwann cell CNS myelination may have therapeutic significance in human myelin disease.
authors.affiliation: Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706, USA. duncani@svm.vetmed.wisc.edu
authors.forename: I D
authors.initials: ID
authors.lastname: Duncan
authors.forename: R L
authors.initials: RL
authors.lastname: Hoffman
mesh_terms: D000818:Animals; D002465:Cell Movement; D002490:Central Nervous System / Q000502:physiology*; D004285:Dogs; D009186:Myelin Sheath / Q000502:physiology*; D051381:Rats; D011922:Rats, Mutant Strains; D012583:Schwann Cells / Q000502:physiology*