title: Management of aneurysms in Behçet's syndrome: an analysis of 24 patients.
abstract: BACKGROUND
  The surgical therapy of Behçet aneurysms is often unsuccessful, resulting in graft occlusions, anastomoses, and/or new aneurysms.
  
  
  METHODS
  Twenty-nine aneurysms were documented in 24 Behçet's patients during a period of 19 years. All patients were male, ranging in age from 20 to 53 years (mean, 35 +/- 7.3 years). The mean duration of disease was 9 +/- 5 years. There were nine abdominal aorta, four iliac, three common femoral, five superficial femoral, four popliteal, one subclavian, one carotid, and one posterior tibial artery aneurysm. In addition, in one patient an aneurysm developed from the arterialized venous conduit that had been inserted for a common femoral artery aneurysm elsewhere. Five patients were already under immunosuppressive therapy for ocular problems at the time of diagnosis. Fifteen patients received immunosuppressive therapy after operation. We performed one abdominal aneurysmorrhaphy, two iliac artery PTFE graft interpositions, two aortobiliac bypasses (PTFE), six aortic tube graft (three PTFE, three Dacron) interpositions, one avrtofemoral bypass (PTFE), two iliofemoral bypasses (PTFE), two superficial femoral artery graft (PTFE) interpositions, and three popliteal graft interpositions (one PTFE, two vein graft). Also as an initial procedure one carotid, one subclavian, four superficial femoral, one popliteal, and one posterior tibial artery were ligated.
  
  
  RESULTS
  Nineteen patients were followed up for a mean duration of 47.3 +/- 27 months (range, 1 to 108 months). The patient with a subclavian aneurysm died of massive bleeding on postoperative day 15. Four patients were lost to follow-up. In the abdominal aortic aneurysm group one patient died of gastrointestinal bleeding 4 years after the operation. Another patient from the same group died 5 years after operation without any vascular disease. In the common femoral artery group the patient with an occluded iliofemoral graft died of an exsanguinating pulmonary artery aneurysm in the first year after operation. Overall, there were five anastomotic aneurysms. In addition, after the initial operation two iliofemoral, one aortofemoral, and one popliteal interposition graft were occluded without disabling ischemia.
  
  
  CONCLUSIONS
  Aneurysms limited to the extremities could be ligated without disabling ischemia. Abdominal aortic aneurysms could be treated with tube graft insertion, giving satisfactory results. Patients could tolerate graft occlusion without major ischemia.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Cerrahpaşa Medical Faculty, University of Istanbul, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Tüzün
authors.forename: K
authors.initials: K
authors.lastname: Beşirli
authors.forename: A
authors.initials: A
authors.lastname: Sayin
authors.forename: F S
authors.initials: FS
authors.lastname: Vural
authors.forename: V
authors.initials: V
authors.lastname: Hamuryudan
authors.forename: N
authors.initials: N
authors.lastname: Hizli
authors.forename: S
authors.initials: S
authors.lastname: Yurdakul
authors.forename: H
authors.initials: H
authors.lastname: Yazici
mesh_terms: D000328:Adult; D000783:Aneurysm / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D001528:Behcet Syndrome / Q000150:complications / Q000473:pathology / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control