The in-vitro activity of an antifungal antibiotic benanomicin A in comparison with amphotericin B.
Benanomicin A showed a broad antifungal spectrum, inhibiting the growth of all test strains of 41 yeasts, 23 dimorphic fungi, 23 dematiaceous fungi, 16 aspergilli, and 19 dermatophytes, with the exception of 12 zygomycetic strains. The MIC values of benanomicin A were comparable to those of amphotericin B against Cryptococcus. Rhodotorula, Trichosporon, Geotrichum, Sporothrix, and some dermatophytes, but were two to eightfold higher than those of amphotericin B against other fungal pathogens tested. The action of benanomicin A was fungicidal.
Watanabe
M
M
Research Center for Medical Mycology, Teikyo University School of Medicine, Tokyo, Japan.
Hiratani
T
T
Uchida
K
K
Ohtsuka
K
K
Watabe
H
H
Inouye
S
S
Kondo
S
S
Takeuchi
T
T
Yamaguchi
H
H
D000666:Amphotericin B / Q000494:pharmacology*; D018943:Anthracyclines; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D000095643:Pradimicins and Benanomicins
D000666:Amphotericin B; D018943:Anthracyclines; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; C056805:benanomicin A; D000095643:Pradimicins and Benanomicins