title: I-123 iofetamine single-photon computed emission tomography in rapid cycling bipolar disorder: a clinical study.
abstract: The regional distribution of I-123 iofetamine (IMP) in the brain of 12 patients with rapid cycling bipolar disorder was studied by single-photon computed emission tomography imaging. Patients who were either medication free (n = 4) or on lithium monotherapy (n = 8) were assessed serially in depressed/dysphoric, manic/hypomanic, or euthymic states. In 23 imaging studies, IMP images of the brain were taken on a GE Starcam system 20 min after injection of 3-4 mCi of I-123 labeled IMP. The I-123 IMP distribution in the anterior part of the temporal lobes was asymmetric in both depression/dysphoria and mania/hypomania but not in euthymia. Images taken sequentially on the same patient showed temporal lobe asymmetry in the pathological mood states that diminished or disappeared in the euthymic state. The observed changes most likely reflect an altered cerebral blood flow and changes in high-affinity IMP binding to amine receptors in the temporal lobes. This pilot study suggests the presence of a state-dependent temporal dysfunction in bipolar disorder.
authors.affiliation: Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia 19104, USA.
authors.forename: L
authors.initials: L
authors.lastname: Gyulai
authors.forename: A
authors.initials: A
authors.lastname: Alavi
authors.forename: K
authors.initials: K
authors.lastname: Broich
authors.forename: J
authors.initials: J
authors.lastname: Reilley
authors.forename: W B
authors.initials: WB
authors.lastname: Ball
authors.forename: P C
authors.initials: PC
authors.lastname: Whybrow
mesh_terms: D000328:Adult; D000339:Affect / Q000502:physiology; D000368:Aged; D000662:Amphetamines; D001143:Arousal / Q000502:physiology; D001714:Bipolar Disorder / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000523:psychology; D001931:Brain Mapping; D003866:Depressive Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000523:psychology; D004292:Dominance, Cerebral / Q000502:physiology; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D013702:Temporal Lobe / Q000000981:diagnostic imaging* / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine