Coexistence of serum anti-DNA topoisomerase I and anti-Sm antibodies: report of 3 cases.
We describe 3 Japanese patients having both serum anti-DNA topoisomerase I and anti-Sm antibodies. All 3 patients had typical features of systemic lupus erythematosus, such as glomerulonephritis, in addition to skin thickening and systemic sclerosis related organ involvement, including pulmonary interstitial fibrosis and renal crisis. This is the first report of the coexistence of these 2 disease specific autoantibodies.
Kameda
H
H
Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Kuwana
M
M
Hama
N
N
Kaburaki
J
J
Homma
M
M
D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology*; D004264:DNA Topoisomerases, Type I / Q000276:immunology*; D004586:Electrophoresis; D005260:Female; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology; D017411:Ribonucleoproteins, Small Nuclear / Q000276:immunology*; D012595:Scleroderma, Systemic / Q000150:complications* / Q000276:immunology; D055517:snRNP Core Proteins
D000974:Antibodies, Antinuclear; D001324:Autoantigens; D017411:Ribonucleoproteins, Small Nuclear; D055517:snRNP Core Proteins; D004264:DNA Topoisomerases, Type I