title: Management of advanced juvenile granulosa cell tumor of the ovary.
abstract: Juvenile granulosa cell tumors (JGCTs) of the ovary are rare. They usually present in children and adolescents. About 90% are diagnosed in early stage (FIGO I) with a favorable prognosis. More advanced stages (FIGO II-IV) have a poor clinical outcome. We report two cases of short-term, disease-free survival of teenagers with Stage III JGCTs treated with aggressive debulking and thorough staging but conservative surgery relative to the uterus and contralateral tube and ovary plus carboplatin and etoposide chemotherapy. These results are encouraging, but the best treatment for extensive and recurrent disease has yet to be determined.
authors.affiliation: Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, New Hanover Regional Medical Center, Wilmington 28402-9025, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Powell
authors.forename: C N
authors.initials: CN
authors.lastname: Otis
mesh_terms: D000293:Adolescent; D003131:Combined Modality Therapy; D005260:Female; D006106:Granulosa Cell Tumor / Q000473:pathology / Q000628:therapy*; D006801:Humans; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000473:pathology / Q000628:therapy*; D012074:Remission Induction