alpha-Adrenergic receptors may contribute to the hypertriglyceridemia associated with tumour growth.
The inoculation of the Yoshida AH-130 ascites hepatoma to rats resulted in an important loss of adipose tissue associated with a decrease in lipoprotein lipase (LPL) activity. Tumour burden also resulted in an important hyperlipidemia which affected both triglyceride and free fatty acids. Administration of phentolamine (an alpha-adrenergic antagonist) to tumour-bearing rats did not influence LPL activity, but it reversed the increase in plasma triglycerides associated with tumour burden. It is suggested that the hypertriglyceridemia associated with tumour growth may be, in part, a consequence of the effect of catecholamines on hepatic triglyceride secretion, via alpha-adrenergic receptors.
López-Soriano
J
J
Unitat de Bioquímica i Biologia Molecular B, Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain.
Carbó
N
N
Costelli
P
P
López-Soriano
F J
FJ
Argilés
J M
JM
D000273:Adipose Tissue / Q000201:enzymology*; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D002100:Cachexia / Q000097:blood / Q000209:etiology; D015228:Hypertriglyceridemia / Q000209:etiology*; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D009363:Neoplasm Proteins / Q000502:physiology*; D009374:Neoplasms, Experimental / Q000150:complications* / Q000378:metabolism; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D014280:Triglycerides / Q000378:metabolism
D000317:Adrenergic alpha-Antagonists; D009363:Neoplasm Proteins; D011942:Receptors, Adrenergic, alpha; D014280:Triglycerides; D008071:Lipoprotein Lipase; D010646:Phentolamine