[Royleanones in the roots of Salvia officinalis L. of domestic provenance and their antimicrobial activity].
The reported investigation of the constituents of the petroleum ether extract of the root of Salvia officinalis L. confirmed the presence of the following diterpene quinones: 12.hydroxy-8, 12-abietadiene-11, 14-dione (royleanone), 7 alpha, 12-dihydroxy-8.12-abistadiene-11-14-dione (horminone) and 7 alpha-acetoxy-12-hydroxy-8, 12-abietadiene-11,14-dione (7-O-acetylhorminone). The compounds were identified on the basic of the interpretation of results of spectral analysis. Isolated royleanones show antimicrobial activity against gram-positive bacteria (Staphylococcus aureus). A study of abietate diterpenoids in the root of Salvia officinalis L. of Slovak provenance has been performed for the first time.
Masterová
I
I
Katedra farmakognógie a botaniky Farmaceutickaj fakulty Univerzity Komenského, Bratislava.
Misíková
E
E
Sirotková
L
L
Vaverková
S
S
Ubik
K
K
D045784:Abietanes; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D018154:Slovakia; D013211:Staphylococcus aureus / Q000187:drug effects
C103400:7-O-acetylhorminone; D045784:Abietanes; D000900:Anti-Bacterial Agents; D004224:Diterpenes; D010936:Plant Extracts; C103399:royleanone; C045490:horminone