title: Cytobrush and endocervical curettage in the diagnosis of dysplasia and malignancy of the uterine cervix.
abstract: BACKGROUND
  The validity of cytobrush and endocervical curettage combined with colposcopically directed biopsies in the diagnosis of cervical dysplasia and malignancy has not been evaluated in randomized trials. We aimed to elucidate the diagnostic validity of the two methods.
  
  
  METHODS
  A prospective, randomized study of 180 consecutive patients. All patients were examined without anesthesia by colposcopically directed biopsies of the ectocervix and randomly assigned to either cytobrush or endocervical curettage. Patients with < or = CIN 1 were investigated with the alternative method three months later. Patients with > or = CIN 2 had a cone biopsy.
  
  
  RESULTS
  One hundred and thirty-one patients were evaluable. The sensitivity of cytobrush and endocervical curettage combined with colposcopically directed biopsies of the ectocervix was 96% and 84% (p = 0.08), respectively. The specificities of the two investigations were 95% and 88%, respectively (p = 0.78). All cytobrush specimens were evaluable but because of a low recovery of endocervical material a diagnosis could not be made in 12% of the patients examined by endocervical curettage.
  
  
  CONCLUSIONS
  The sensitivity of the combined use of cytobrush and biopsies of the ectocervix was equal to or higher than the sensitivity of endocervical curettage and ectocervical biopsies. The specificities of the two investigations were much alike. All cytobrush specimens were evaluable but a diagnosis could not be performed in 12% of the endocervical curettage specimens because of too little endocervical material. Furthermore, cytobrush is less inconvenient to the patient. Therefore, in the follow-up of patients with cervical dysplasia endocervical curettage may be replaced with cytobrush.
authors.affiliation: Department of Gynecology and Obstetrics, Randers Regional Hospital, Randers, Denmark.
authors.forename: S T
authors.initials: ST
authors.lastname: Mogensen
authors.forename: M
authors.initials: M
authors.lastname: Bak
authors.forename: M
authors.initials: M
authors.lastname: Dueholm
authors.forename: L
authors.initials: L
authors.lastname: Frost
authors.forename: N O
authors.initials: NO
authors.lastname: Knoblauch
authors.forename: J
authors.initials: J
authors.lastname: Praest
authors.forename: H
authors.initials: H
authors.lastname: Svanholm
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003663:Decision Trees; D004107:Dilatation and Curettage; D005260:Female; D006801:Humans; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology; D014626:Vaginal Smears / Q000295:instrumentation*