title: [Sensitivity and selectivity enhancing parameters in the determination of substances in biological material in the pg range with HPLC and electrochemistry detection using a new xanthine derivative].
abstract: Quality aspects influencing the determination of a xanthine derivative in plasma by HPLC and coulometric detection are described. The experiences made within the scope of these experiments enable an adequate optimization of the method and a practical and time saving qualification of the status of sensitivity of the electrochemical working electrode.
authors.affiliation: Institut für Pharmazeutische Chemie der Karl-Franzens-Universität Graz, Austria.
authors.forename: R
authors.initials: R
authors.lastname: Wintersteiger
authors.forename: G
authors.initials: G
authors.lastname: Berliz
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004563:Electrochemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D010726:Phosphodiesterase Inhibitors / Q000097:blood*; D014970:Xanthines / Q000097:blood*
chemical_list: D007202:Indicators and Reagents; C095074:MKS 213492; D010726:Phosphodiesterase Inhibitors; D014970:Xanthines