[Infant mortality among children of 35-39 year-old mothers. An analysis of development of death cause categories and among multiple pregnancies during the period 1980-1993].
The perinatal mortality in Denmark decreased significantly from the late 1980's to 1990-1993 but increased among births by mothers aged 35-39 years, from 9.7 in 1985-1989 to 11.0 per 1000 born in 1990-1993. No increase was observed among infants of teen-age mothers or mothers older than 40 years. Based upon data from the Danish National Register of Causes of Death and the Birth Register all perinatal deaths in 1980-1993 were classified in nine categories including pathoanatomical, obstetrical and paediatric criteria. The increase in perinatal mortality in infants born to mothers aged 35-39 years was because of more deaths due to congenital birth defects, intra-partum events and foeto-placental dysfunction, while mortality due to prematurity decreased. The rate of multiple pregnancies and of primiparas increased significantly among 35-39 year-old mothers. With reference to international literature, the article discusses the possible impact of in-vitro fertilisation and other fertility treatments upon the special trend in perinatal mortality in this mother age-group. A national Danish IVF-register was first established in 1994 and will in the future allow concrete analyses of the outcome of IVF-pregnancies.
Helweg-Larsen
K
K
Dansk Institut for Klinisk Epidemiologi, København.
Bille
H
H
Wichmann
B
B
D000328:Adult; D002423:Cause of Death; D000013:Congenital Abnormalities / Q000401:mortality; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005307:Fertilization in Vitro; D005313:Fetal Death / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D008423:Maternal Age; D011247:Pregnancy; D018566:Pregnancy, High-Risk; D011272:Pregnancy, Multiple; D012042:Registries