[Drug intolerance].
The authors present experimental data on luminol-dependent neutrophil chemiluminescence of blood from patients with drug intolerance. A decrease in intensity of neutrophil and whole blood chemiluminescence was registered in the presence of intolerated drugs. In acute phase of generalized intolerance reaction the chemiluminescence test showed readiness of the blood cells to react inadequately to the contact with different drugs leading to variations in generation of active oxygen forms. Improvement in patients' condition was followed by narrowing spectrum of drugs causing a decrease in the intensity of the chemiluminescence. Later, the chemiluminescence ratio remained low in testing only those drugs causing intolerance reaction.
Didkovskiĭ
N A
NA
Reshetova
N V
NV
Treskunov
V K
VK
Malashenkova
I K
IK
Sarsaniia
Zh Sh
ZhSh
D001782:Blood Donors; D004361:Drug Tolerance; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D007202:Indicators and Reagents; D008163:Luminescent Measurements; D008165:Luminol / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D017382:Reactive Oxygen Species
D007202:Indicators and Reagents; D017382:Reactive Oxygen Species; D008165:Luminol