title: Long-term follow-up after surgical treatment of obstructive sleep apnoea by maxillomandibular advancement.
abstract: Obstructive sleep apnoea (OSA) is a common disorder with potentially serious consequences. If maxillary and mandibular deficiency, often in combination with a narrow posterior airway space is present, therapy of OSA by maxillomandibular osteotomy is possible. However, long-term follow-up of patients undergoing these procedures is lacking. We present the results of 15 OSA patients (1 female and 14 males), who underwent maxillomandibular advancement surgery with a follow-up of at least 2 yrs. Polysomnography was performed before surgery, after 6-12 weeks, and 1 and 2 yrs postoperatively. Mean apnoea/hypopnoea index (AHI) decreased from 51.4 events.h-1 before therapy to 5.0 events.h-1 6 weeks postoperatively, and was 8.5 events.h-1 after 2 yrs. Oxygen saturation significantly increased following surgery. After 2 yrs, the AHI was < 10 events.h-1 in 12 out of 15 subjects. No significant changes were found comparing the 6-12 weeks versus the 2 year follow-up data. The significant increase in stage 3/4 non-rapid eye movement (NREM) sleep and decrease in stage 1 NREM sleep, indicative of the restoration of normal physiological sleep structure, persisted in 14 of the 15 subjects 2 yrs postoperatively. Three patients, however, did not show satisfactory improvement 2 yrs postoperatively; two showed obstructive and one central respiratory events. This study demonstrates that maxillomandibular advancement is successful in a high percentage of patients carefully selected by cephalometric and polysomnographic investigation. Postoperative success has proved to be stable over a period of 2 yrs. Further preoperative evaluation seems necessary in patients with predominantly mixed or central apnoeas.
authors.affiliation: Schlafmedizinisches Labor, Medizinische Poliklinik, Philipps-Universität Marburg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Conradt
authors.forename: W
authors.initials: W
authors.lastname: Hochban
authors.forename: U
authors.initials: U
authors.lastname: Brandenburg
authors.forename: J
authors.initials: J
authors.lastname: Heitmann
authors.forename: J H
authors.initials: JH
authors.lastname: Peter
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001049:Apnea / Q000503:physiopathology; D002508:Cephalometry; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008334:Mandible / Q000601:surgery*; D008437:Maxilla / Q000601:surgery*; D010027:Osteotomy; D019340:Osteotomy, Le Fort; D010101:Oxygen Consumption / Q000502:physiology; D017286:Polysomnography; D012891:Sleep Apnea Syndromes / Q000503:physiopathology / Q000601:surgery*; D012894:Sleep Stages / Q000502:physiology; D012895:Sleep, REM / Q000502:physiology; D016896:Treatment Outcome