title: The vav proto-oncogene product (p95vav) interacts with the Tyk-2 protein tyrosine kinase.
abstract: The vav proto-oncogene product participates in the signaling pathways activated by various cell-surface receptors, including the type I IFN receptor. During engagement of the type I IFN receptor, p95vav is phosphorylated on tyrosine residues, but the kinase regulating its phosphorylation has not been identified to date. Our studies demonstrate that p95vav forms a stable complex with the IFN-receptor-associated Tyk-2 kinase in vivo, and strongly suggest that this kinase regulates its phosphorylation on tyrosine. Thus, p95vav is engaged in IFN-signaling by a direct interaction with the functional type I IFN receptor complex to transduce downstream signals.
authors.affiliation: Department of Medicine, University of Illinois at Chicago, 60607, USA.
authors.forename: S
authors.initials: S
authors.lastname: Uddin
authors.forename: M
authors.initials: M
authors.lastname: Sweet
authors.forename: O R
authors.initials: OR
authors.lastname: Colamonici
authors.forename: J J
authors.initials: JJ
authors.lastname: Krolewski
authors.forename: L C
authors.initials: LC
authors.lastname: Platanias
mesh_terms: D016227:Benzoquinones; D018797:Cell Cycle Proteins; D004791:Enzyme Inhibitors / Q000494:pharmacology; D019833:Genistein; D006801:Humans; D016898:Interferon-alpha / Q000378:metabolism / Q000494:pharmacology; D007529:Isoflavones / Q000494:pharmacology; D047029:Lactams, Macrocyclic; D009101:Multiple Myeloma / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D010766:Phosphorylation; D011233:Precipitin Tests; D011505:Protein-Tyrosine Kinases; D011506:Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D051567:Proto-Oncogene Proteins c-vav; D011809:Quinones / Q000494:pharmacology; D017828:Rifabutin / Q000031:analogs & derivatives; D019311:Staurosporine / Q000494:pharmacology; D053634:TYK2 Kinase; D014407:Tumor Cells, Cultured; D014443:Tyrosine / Q000378:metabolism
chemical_list: D016227:Benzoquinones; D018797:Cell Cycle Proteins; D004791:Enzyme Inhibitors; D016898:Interferon-alpha; D007529:Isoflavones; D047029:Lactams, Macrocyclic; C000715470:MAS1 protein, human; D011506:Proteins; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D051567:Proto-Oncogene Proteins c-vav; D011809:Quinones; C496618:VAV1 protein, human; D017828:Rifabutin; D014443:Tyrosine; C020754:herbimycin; D019833:Genistein; D011505:Protein-Tyrosine Kinases; D053634:TYK2 Kinase; C070139:TYK2 protein, human; D019311:Staurosporine