[Fat-soluble vitamins E and A in the tumor tissue and in the blood of patients with renal-cell cancer].
The level of vitamin E was measured in 31 renal carcinomas and unaffected renal cortex taken as control. Two groups were formed in respect to cell composition of the carcinoma: 14 tumors composed of clear cells; 17 tumors composed of other types cells. Vitamin E concentrations and total lipids in the tumor tissue were elevated. Despite a significant positive correlation between levels of vitamin E and lipids in cancer tissue, high content of lipids is not the main reason of vitamin E accumulation. Concentration of vitamin A measured in 17 carcinomas was similar to control as per 1 mg of tissue lipids. Blood levels of vitamin E and total lipids in 12 patients with renal cell carcinoma were significantly higher than in healthy subjects and returned to normal after nephrectomy.
Nikiforova
N V
NV
Chumakov
A M
AM
Kirpatovskiĭ
V I
VI
Komarova
V A
VA
D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000737:chemistry* / Q000601:surgery; D005260:Female; D006801:Humans; D007672:Kidney Cortex / Q000737:chemistry; D007680:Kidney Neoplasms / Q000737:chemistry* / Q000601:surgery; D008055:Lipids / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D012995:Solubility; D014801:Vitamin A / Q000032:analysis*; D014810:Vitamin E / Q000032:analysis*
D008055:Lipids; D014801:Vitamin A; D014810:Vitamin E