title: Suspected acute interstitial nephritis induced by piperacillin-tazobactam.
abstract: A 51-year-old woman developed an acute onset of renal dysfunction accompanied by rash, lumbar pain, arthralgias, fever, eosinophiluria, and an elevated serum creatinine after 6 days of intravenous piperacillin-tazobactam therapy. On discontinuing piperacillin-tazobactam and after a 21-day course of prednisone, the patient's constitutional symptoms dissipated and her renal function returned to baseline. Acute interstitial nephritis has been reported as an adverse effect of many drugs, including antibiotics, but not, to our knowledge, after piperacillin-tazobactam. The time course of events suggested that piperacillin-tazobactam was the cause of acute interstitial nephritis in this patient.
authors.affiliation: Department of Pharmacy, New England Medical Center, Boston, MA 02111, USA.
authors.forename: M W
authors.initials: MW
authors.lastname: Pill
authors.forename: C V
authors.initials: CV
authors.lastname: O'Neill
authors.forename: M M
authors.initials: MM
authors.lastname: Chapman
authors.forename: A K
authors.initials: AK
authors.lastname: Singh
mesh_terms: D000208:Acute Disease; D003404:Creatinine / Q000097:blood; D004359:Drug Therapy, Combination / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D010397:Penicillanic Acid / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D010878:Piperacillin / Q000009:adverse effects / Q000627:therapeutic use; D000077725:Piperacillin, Tazobactam Drug Combination
chemical_list: D000077725:Piperacillin, Tazobactam Drug Combination; D010397:Penicillanic Acid; D003404:Creatinine; D010878:Piperacillin