title: [Chronic insulin overdosage, hyperinsulinemia, atherosclerosis].
abstract: Biochemical and immunological indices were studied with regard to insulin dose in 321 patients with diabetes mellitus type I. Overdosage of insulin in these patients induced significantly more frequently clinical manifestations of atherosclerosis, marked shifts in lipid spectrum of the serum and in immunological picture. In diabetics on physiological doses of insulin atherosclerosis is a rare finding, lipid spectrum and immunological indices in stable normoglycemia did not differ much from controls. Implication of chronic insulin overdosage in mechanism of atherosclerosis onset is suggested.
authors.affiliation: Department of Faculty Therapy, State Medical Univesity, Saint-Petersburg.
authors.forename: E I
authors.initials: EI
authors.lastname: Krasil'nikova
authors.forename: V A
authors.initials: VA
authors.lastname: Almazov
authors.forename: I V
authors.initials: IV
authors.lastname: Blagosklonnaia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001161:Arteriosclerosis / Q000097:blood / Q000209:etiology* / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D062787:Drug Overdose; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood / Q000209:etiology* / Q000276:immunology; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D007328:Insulin / Q000009:adverse effects*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D007004:Hypoglycemic Agents; D007328:Insulin; D008055:Lipids