title: Confluent and reticulated papillomatosis responsive to minocycline.
abstract: Confluent and reticulated papillomatosis (Gougerot and Carteaud) is a distinctive clinico-pathologic entity of unknown etiology, whose relationship to fungi is still controversial. We report a 15-year-old Japanese male in whom Malassezia yeasts were found on direct microscopic examination. Treatment with oral itraconazole initially resulted in partial improvement but later became ineffective. The rash virtually disappeared with administration of minocycline. These observations indicate that the role of Malassezia yeasts in the pathogenesis of this disease is probably less important than that of microorganisms sensitive to minocycline.
authors.affiliation: Division of Dermatology, Ogikubo Hospital, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Shimizu
authors.forename: H
authors.initials: H
authors.lastname: Han-Yaku
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003881:Dermatomycoses / Q000150:complications / Q000188:drug therapy; D005500:Follow-Up Studies; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage / Q000627:therapeutic use; D008290:Malassezia / Q000302:isolation & purification; D008297:Male; D008911:Minocycline / Q000008:administration & dosage / Q000627:therapeutic use*; D010212:Papilloma / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D012008:Recurrence; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D017964:Itraconazole; D008911:Minocycline