title: Major depression following smoking cessation.
abstract: OBJECTIVE
  The authors examined the incidence and predictors of major depression following successful smoking cessation treatment, with special attention to the influence of past major depression.
  
  
  METHODS
  Three-month follow-up data were obtained from 126 subjects who successfully completed a 10-week smoking cessation program.
  
  
  RESULTS
  The 3-month incidence of new major depression following treatment for nicotine dependence was 2%, 17%, and 30% among subjects with histories of no major depression, single major depression, and recurrent major depression, respectively. A history of major depression and persistent withdrawal symptoms independently predicted posttreatment major depression.
  
  
  CONCLUSIONS
  Continued patient care beyond the 2-4-week period associated with the nicotine withdrawal syndrome is indicated when abstinence is attempted by smokers with prior major depression.
authors.affiliation: Department of Psychiatry, College of Physicians and Surgeons, Columbia, University, New York, NY, USA.
authors.forename: L S
authors.initials: LS
authors.lastname: Covey
authors.forename: A H
authors.initials: AH
authors.lastname: Glassman
authors.forename: F
authors.initials: F
authors.lastname: Stetner
mesh_terms: D003866:Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000009:adverse effects; D016017:Odds Ratio; D010555:Personality Inventory; D012008:Recurrence; D016540:Smoking Cessation; D013375:Substance Withdrawal Syndrome / Q000453:epidemiology / Q000209:etiology*; D014029:Tobacco Use Disorder / Q000534:rehabilitation
chemical_list: D009538:Nicotine