title: Three cases of linear lichen planus caused by dental metal compounds.
abstract: Three cases of linear lichen planus on the lower extremities unaccompanied by mucous lesions are described. Dental metal compounds were thought to be the precipitating factor in all cases. Skin lesions did not respond to topical steroid ointment or antihistamines. Two cases showed a positive patch test reaction to gold (HAuCl4) and a positive lymphocyte stimulation test to gold compound (Gold sodium thiomalate). One case showed a positive patch test reaction to mercury (HgCl2), but a negative lymphocyte stimulation test. Suspected metal compounds were demonstrated in their dental materials. Removal of gold materials in one case gradually improved the lesions within 6 months with a transient erythematous swelling of the face shortly after removal of the metal. Both of these cases responded to oral disodium chromoglycate therapy. These results suggest that metal compound specific T cells might be responsible for the development of linear lichen planus.
authors.affiliation: Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, Japan.
authors.forename: G
authors.initials: G
authors.lastname: Sasaki
authors.forename: H
authors.initials: H
authors.lastname: Yokozeki
authors.forename: I
authors.initials: I
authors.lastname: Katayama
authors.forename: K
authors.initials: K
authors.lastname: Nishioka
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D003764:Dental Materials / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D017612:Gold Compounds / Q000009:adverse effects*; D006801:Humans; D008010:Lichen Planus / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010328:Patch Tests
chemical_list: D003764:Dental Materials; D017612:Gold Compounds