title: Perioperative collapse: prevalence of latex allergy in patients sensitive to anaesthetic agents.
abstract: The evidence in the literature suggests that the prevalence of latex allergy in the general population is approximately 1%. With increasing awareness of transmission of HIV and other infections such as hepatitis B, the use of latex gloves and condoms has escalated in recent years. As cheaper latex gloves of variable and doubtful quality flood the market, health care workers and patients are being increasingly sensitized by these latex products. A retrospective study investigated the prevalence of latex allergy in a cohort of 26 patients who suffered perioperative anaphylactoid reactions. 84% of these patients were hypersensitive to at least 1 anaesthetic-related agent. 7.7% were also allergic to latex (p = 0.028). Atopy is a strong predisposing factor (p = 0.006). An accurate preoperative history of atopy and past reactions to latex will identify most at-risk patients. Prick test and RAST to latex will confirm the latex allergy. Anaesthetists, surgeons, allergists and other health practitioners should be aware of this problem.
authors.affiliation: Department of Dermatology, North Staffordshire Hospital, Keele, UK.
authors.forename: B B
authors.initials: BB
authors.lastname: Tan
authors.forename: J T
authors.initials: JT
authors.lastname: Lear
authors.forename: J
authors.initials: J
authors.lastname: Watts
authors.forename: P
authors.initials: P
authors.lastname: Jones
authors.forename: J S
authors.initials: JS
authors.lastname: English
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000707:Anaphylaxis / Q000139:chemically induced*; D000777:Anesthetics / Q000009:adverse effects*; D018686:Anesthetics, Intravenous / Q000009:adverse effects; D015331:Cohort Studies; D017280:Condoms / Q000009:adverse effects; D003876:Dermatitis, Atopic / Q000150:complications; D005260:Female; D005932:Gloves, Surgical / Q000009:adverse effects; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology*; D007431:Intraoperative Complications / Q000139:chemically induced*; D007840:Latex / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000009:adverse effects; D015995:Prevalence; D011852:Radioallergosorbent Test; D012189:Retrospective Studies; D012307:Risk Factors; D012882:Skin Tests
chemical_list: D000777:Anesthetics; D018686:Anesthetics, Intravenous; D007840:Latex; D009465:Neuromuscular Agents