Monovalent and polymeric 5N-thioacetamido sialosides as tightly-bound receptor analogs of influenza viruses.
A possible approach to the development of synthetic inhibitors of influenza virus attachment to host cells is based on the anchoring of the minimum receptor determinant of influenza virus, sialic acid, to a polymeric carrier. In this study, the effect of substitution of oxygen by sulphur in the 5N-acetyl moiety of sialic acid on the binding of monovalent and polymeric sialosides by A and B influenza virus strains was investigated. The polymeric inhibitor with pendant 5N-thioacetylneuraminic acid residues was found to be more broadly active against different virus stains that the one prepared from the Neu5Ac ligand.
Tuzikov
A B
AB
Shemyakan Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Byramova
N E
NE
Bovin
N V
NV
Gambaryan
A S
AS
Matrosovich
M N
MN
D009980:Influenza A virus / Q000378:metabolism*; D009981:Influenza B virus / Q000378:metabolism*; D015394:Molecular Structure; D019158:N-Acetylneuraminic Acid / Q000138:chemical synthesis / Q000378:metabolism; D011991:Receptors, Virus / Q000378:metabolism*; D012794:Sialic Acids / Q000138:chemical synthesis / Q000378:metabolism*
D011991:Receptors, Virus; D012794:Sialic Acids; D019158:N-Acetylneuraminic Acid