TRF1, a mammalian telomeric protein.
Telomerase adds TTAGGG repeats onto mammalian chromosome ends, replenishing the terminal sequence loss incurred during DNA replication. This maintenance of telomeric DNA preserves binding sites for telomeric proteins, which form a protective nucleoprotein complex at chromosome ends. The recent isolation of TRF1, the mammalian telomeric-repeat binding factor, should now allow the structure and function of the telomeric complex to be examined in detail.
Smith
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Rockefeller University, New York, NY 10021, USA.
de Lange
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D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D016147:Genes, Tumor Suppressor; D006801:Humans; D008969:Molecular Sequence Data; D020626:Oncogene Proteins v-myb; D011487:Protein Conformation; D012091:Repetitive Sequences, Nucleic Acid; D015682:Retroviridae Proteins, Oncogenic / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D016615:Telomere / Q000737:chemistry / Q000378:metabolism; D035321:Telomeric Repeat Binding Protein 1; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D004268:DNA-Binding Proteins; D020626:Oncogene Proteins v-myb; D015682:Retroviridae Proteins, Oncogenic; D035321:Telomeric Repeat Binding Protein 1; D014157:Transcription Factors