[An analysis of the cellular distribution of chromosome aberrations induced in human lymphocytes after a single irradiation and under conditions of preliminary adaptive exposure].
Irradiation by an adaptive dose 0.05 Gy at the G0 stage decreased the number of chromosome aberrations induced in lymphocytes by a challenge dose 0.5 Gy at the G2 stage. Adaptive response was not observed at the G1 stage, when the cells were exposed to adaptive dose 0.05 Gy and challenge dose 1.0 Gy respectively after 24 h and 29 h incubation with PHA. In lymphocytes exposed to 1.0 Gy at the G1 stage, cellular distribution of chromosomal aberrations followed the Poisson distribution, while in lymphocytes exposed to 0.5 Gy at the G2 stage, the distribution of aberrations differed from the Poisson distribution and was nearer to the degenerated Poisson distribution. The adaptive dose 0.05 Gy did not alter the distribution of chromosome aberrations induced by the challenge dose at the G1 or the G2 stages. The role of independent and whole-cellular repair in the formation of chromosome and chromatid aberration is discussed.
Riabchenko
N I
NI
Antoshchina
M M
MM
Nasonova
V A
VA
Fesenko
E V
EV
D000222:Adaptation, Physiological / Q000528:radiation effects*; D002478:Cells, Cultured; D016009:Chi-Square Distribution; D002869:Chromosome Aberrations; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D007399:Interphase / Q000528:radiation effects; D008214:Lymphocytes / Q000528:radiation effects* / Q000648:ultrastructure; D016012:Poisson Distribution; D013997:Time Factors