title: Antibodies to Tamm-Horsfall protein in patients treated with extracorporeal shock wave lithotripsy (ESWL).
abstract: The aim of this study was to determine antibodies to Tamm-Horsfall protein in patients with nephrolithiasis treated with extracorporeal shock wave lithotripsy (ESWL). The values of antibodies to Tamm-Horsfall protein were determined by direct enzyme immunoassay. No statistically significant differences (P > 0.05) were observed for the IgG and IgM classes of antibodies between the groups of healthy subjects and patients with nephrolithiasis before, and 30 and 60 days after ESWL. The values of IgA class determined 30 days after treatment were significantly higher (P < 0.05) in patients, which could be due to the stimulation of the immune system. The highest values of antibodies to Tamm-Horsfall protein were obtained in both groups in the test with secondary antibodies directed toward IgM class, implicated at the presence of cross-reactive antibodies. Determination of antibodies to THP subunits isolated form urine of patients with nephrolithiasis should be performed.
authors.affiliation: Department of Medicine, University Hospital Center Zagreb, School of Medicine, University of Zagreb, Croatia.
authors.forename: B
authors.initials: B
authors.lastname: Jelaković
authors.forename: Z
authors.initials: Z
authors.lastname: Mareković
authors.forename: I
authors.initials: I
authors.lastname: Krhen
authors.forename: J
authors.initials: J
authors.lastname: Benković
authors.forename: N
authors.initials: N
authors.lastname: Cikes
authors.forename: D
authors.initials: D
authors.lastname: Cvoriscec
authors.forename: D
authors.initials: D
authors.lastname: Kuzmanić
authors.forename: T
authors.initials: T
authors.lastname: Roncević
authors.forename: Z
authors.initials: Z
authors.lastname: Krznarić
mesh_terms: D000328:Adult; D000368:Aged; D000906:Antibodies / Q000032:analysis*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007669:Kidney Calculi / Q000276:immunology* / Q000628:therapy; D008096:Lithotripsy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009088:Mucoproteins / Q000276:immunology*; D058949:Uromodulin
chemical_list: D000906:Antibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009088:Mucoproteins; C548612:UMOD protein, human; D058949:Uromodulin