[The effect of CO2 on the blocking of excitation conduction by local anesthetics in feline A-delta and C fibers].
The data obtained showed that the CO2 potentiated the conduction blockade of the saphenous nerve with tertiary amine trimecaine in anesthetised cats. The data suggests that acidification of cytoplasm with increased CO2 increases the concentration of active cationic protonated forms of a local anesthetic agent.
Mangusheva
N A
NA
Katalymov
L L
LL
Solov'ev
A S
AS
D000200:Action Potentials / Q000187:drug effects; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D001566:Benzocaine / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000494:pharmacology*; D002415:Cats; D004347:Drug Interactions; D004558:Electric Stimulation; D006863:Hydrogen-Ion Concentration; D009412:Nerve Fibers / Q000187:drug effects* / Q000502:physiology; D009413:Nerve Fibers, Myelinated / Q000187:drug effects* / Q000502:physiology; D009433:Neural Inhibition / Q000187:drug effects*; D014288:Trimecaine / Q000494:pharmacology*
D000779:Anesthetics, Local; D002245:Carbon Dioxide; D014288:Trimecaine; D001566:Benzocaine