title: Chemistry of indoles carrying a basic function, Part 3. Synthesis of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H)-ones with antihypoxic effects.
abstract: Hydroxyindolones (1-6, 15-16) were transformed into isatinylidenes (7, 9-13, 17-19) by dehydration with 4-toluenesulfonic acid. The dimer-type compounds (14, 20) were also isolated in a few cases. The obtained isatinylidenes were transformed into 3-spiro-cyclopropane-oxindoles (21-32) with dimethyloxosulfonium methylide. Compound 22 shows protective effects against hypobaric hypoxia and triethyltin induced brain edema.
authors.affiliation: Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest, Hungary.
authors.forename: I
authors.initials: I
authors.lastname: Moldvai
authors.forename: E
authors.initials: E
authors.lastname: Gács-Baitz
authors.forename: M
authors.initials: M
authors.lastname: Balázs
authors.forename: M
authors.initials: M
authors.lastname: Incze
authors.forename: C
authors.initials: C
authors.lastname: Szántay
mesh_terms: D000399:Air Pressure; D000818:Animals; D001929:Brain Edema / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control*; D000860:Hypoxia / Q000150:complications / Q000188:drug therapy*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D009682:Magnetic Resonance Spectroscopy; D051381:Rats; D011918:Rats, Inbred SHR; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D014267:Triethyltin Compounds
chemical_list: D007211:Indoles; D013141:Spiro Compounds; D014267:Triethyltin Compounds