Superoxide dismutase activity and lipid peroxidation in the liver of guinea pig infected with Leptospira interrogans.
Superoxide dismutase (SOD) activity and the degree of lipid peroxidation were studied over a two week period in guinea pigs infected with Leptospira interrogans derived from wild mice. The total SOD activity in infected host liver increased by four-fold two days after infection; this was followed by a 20% decrease resulting in levels comparable to normal, uninfected liver. During the period of decreasing SOD activity after day two, the levels of TBA-reactive material (TBARS) are increased by three-fold in infected guinea pig, liver, compared to uninfected liver. The results indicate that SOD attenuates intracellular superoxide-mediated toxic effects in guinea pigs infected with L. interrogans. In addition, electron microscopy structure demonstrates correlated pathogenic shrinkage of mitochondrial and Kupffer cell structures.
Kim
Y G
YG
Department of Biological Science, College of Natural Sciences, Chosun University, Kwangju, Korea.
Jeon
D Y
DY
Yang
M K
MK
D000818:Animals; D006168:Guinea Pigs; D015227:Lipid Peroxidation; D008099:Liver / Q000201:enzymology* / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008854:Microscopy, Electron; D013482:Superoxide Dismutase / Q000378:metabolism*; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D014895:Weil Disease / Q000201:enzymology* / Q000473:pathology
D017392:Thiobarbituric Acid Reactive Substances; D013482:Superoxide Dismutase