title: Primary aldosteronism with bilateral multiple aldosterone-producing adrenal adenomas.
abstract: A 41-year-old woman developed primary aldosteronism due to bilateral multiple aldosterone-producing adenomas (APA). She was suspected to have idiopathic hyperaldosteronism (IHA) 7 years previously. Although preoperative data suggest APA and IHA was suspected in a postoperative microscopic specimen, a definite clinical diagnosis could not be made. Cytochrome P-450 and other enzymes involved in aldosterone synthesis were found in the tumor portions but not in the zona glomerulosa of attached adrenals, which histopathologically showed "paradoxical hyperplasia". This was a rare case of bilateral multiple APA, which could be differentiated from IHA by immunohistochemical analysis of adrenal steroidogenic enzymes.
authors.affiliation: Department of Internal Medicine, Kin-ikyo chuo Hospital.
authors.forename: A
authors.initials: A
authors.lastname: Matsuda
authors.forename: M
authors.initials: M
authors.lastname: Beniko
authors.forename: A
authors.initials: A
authors.lastname: Ikota
authors.forename: M
authors.initials: M
authors.lastname: Yamazaki
authors.forename: S
authors.initials: S
authors.lastname: Koizumi
authors.forename: H
authors.initials: H
authors.lastname: Mizumoto
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Matsuya
authors.forename: H
authors.initials: H
authors.lastname: Kunita
authors.forename: Y
authors.initials: Y
authors.lastname: Mashio
authors.forename: H
authors.initials: H
authors.lastname: Sasano
mesh_terms: D000236:Adenoma / Q000378:metabolism* / Q000473:pathology; D000310:Adrenal Gland Neoplasms / Q000378:metabolism* / Q000473:pathology; D000324:Adrenocorticotropic Hormone; D000328:Adult; D000450:Aldosterone / Q000378:metabolism*; D002940:Circadian Rhythm; D003907:Dexamethasone; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006929:Hyperaldosteronism / Q000209:etiology*
chemical_list: D000450:Aldosterone; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone