Actin dynamics in vivo.
Actin dynamics in lamellipodia are driven by continuous cycles of actin polymerization, retrograde flow, and depolymerization. In the past year, advances have been made in identifying signaling pathways that regulate actin-filament uncapping and polymerization, in determining the role of myosin motor proteins in retrograde flow, and in evaluating the role of severing proteins in actin depolymerization. Both Listeria monocytogenes and Saccharomyces cerevisiae have emerged as powerful model organisms for studying actin dynamics in cells.
Welch
M D
MD
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143-0450, USA. welch@cgl.ucsf.edu
Mallavarapu
A
A
Rosenblatt
J
J
Mitchison
T J
TJ
D000199:Actins / Q000737:chemistry / Q000502:physiology*; D001426:Bacterial Proteins / Q000737:chemistry / Q000502:physiology*; D005656:Fungal Proteins / Q000737:chemistry / Q000502:physiology*
D000199:Actins; D001426:Bacterial Proteins; D005656:Fungal Proteins