Esophageal carcinoma presenting with nephrotic syndrome: association with anti-neutrophil cytoplasmic antibody.
Malignancy is a cause of membranous glomerulonephritis. We report a patient with an otherwise asymptomatic squamous cell carcinoma of the esophagus whose presenting manifestation was membranous glomerulonephritis and nephrotic syndrome. Perinuclear anti-neutrophil cytoplasmic antibody was positive. This is the first reported case of perinuclear anti-neutrophil cytoplasmic antibody associated with paraneoplastic glomerulonephritis and nephrotic syndrome due to esophageal squamous cell carcinoma.
Yedidag
A
A
Department of Gastroenterology, Christ Hospital & Medical Center, Oak Lawn, Illinois 60453, USA.
Zikos
D
D
Spargo
B
B
MacEntee
P
P
Berkelhammer
C
C
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis*; D004938:Esophageal Neoplasms / Q000175:diagnosis*; D017809:Fatal Outcome; D015433:Glomerulonephritis, Membranous / Q000175:diagnosis; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000175:diagnosis*; D009780:Occult Blood
D019268:Antibodies, Antineutrophil Cytoplasmic