title: Urinary tract dysfunction in multiple sclerosis: is there a relation with disease-related parameters?
abstract: The lower urinary tract is affected by multiple sclerosis in many patients. We screened urologically and neurologically 120 patients with a confirmed diagnosis of multiple sclerosis. The mean age was 42 years (range 22 to 69 years). Urodynamic investigation as well as neuro-urophysiological investigations were performed in all patients. Renal ultrasound was used to study morphology, and excretory urogram (IVU) was used to assess renal function and the upper urinary tracts in 105 patients. Obstructive symptoms were found more commonly than irritative symptoms. The urinary symptoms were found to be related to disease duration and not to disability status. Urodynamic abnormalities were statistically significantly related to disease duration (X2 = 38.51; P = 0.0001), and to the disability status (X2 = 76.70; P = 0.0001). Few patients, only 3.3%, had upper urinary tract dilatation. With medical management, hydronephrosis disappeared in all of the patients and did not recur. A combination of oral pharmacological agents and clean intermittent catheterization was used in the majority of the patients. We conclude that lower urodynamic abnormalities can be present in every patient with multiple sclerosis, and appear to be related to disease duration and disability status, thus early treatment based upon urodynamic evaluation and close follow-up can reduce morbidity and improve the quality of life.
authors.affiliation: Clinica Urologica, Università di Cagliari, Italia.
authors.forename: D
authors.initials: D
authors.lastname: Porru
authors.forename: G
authors.initials: G
authors.lastname: Campus
authors.forename: A
authors.initials: A
authors.lastname: Garau
authors.forename: M
authors.initials: M
authors.lastname: Sorgia
authors.forename: A C
authors.initials: AC
authors.lastname: Pau
authors.forename: G
authors.initials: G
authors.lastname: Spinici
authors.forename: M P
authors.initials: MP
authors.lastname: Pischedda
authors.forename: M G
authors.initials: MG
authors.lastname: Marrosu
authors.forename: R M
authors.initials: RM
authors.lastname: Scarpa
authors.forename: E
authors.initials: E
authors.lastname: Usai
mesh_terms: D000328:Adult; D000368:Aged; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D006869:Hydronephrosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D007677:Kidney Function Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications*; D014463:Ultrasonography; D014517:Ureteral Obstruction / Q000503:physiopathology; D014551:Urinary Tract / Q000000981:diagnostic imaging / Q000503:physiopathology*; D014563:Urodynamics / Q000502:physiology*; D014567:Urography; D014570:Urologic Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology