title: Xylaramide, a new antifungal compound, and other secondary metabolites from Xylaria longipes.
abstract: Xylaramide (1), possessing potent antifungal activity towards Nematospora coryli and Saccharomyces cerevisiae, was isolated from the culture fluids of the wood-inhabiting ascomycete Xylaria longipes together with tyrosol (2), 2,5-bis(hydroxymethyl)furan (3) and 2-hexyli-dene-3-methylsuccinic acid (4). The latter has been known as a Xylaria metabolite for many years. Compounds 2 and 3 have been previously reported from other fungi, whereas 1 is a new natural N-(2-phenylethenyl)-2-hydroxypropanamide. The isolation, structure determination and biological properties of xylaramide are described. The biological activities of the other compounds are included.
authors.affiliation: LB Biotechnologie, Universität Kaiserslautern, Bundesrepublik, Deutschland.
authors.forename: G
authors.initials: G
authors.lastname: Schneider
authors.forename: H
authors.initials: H
authors.lastname: Anke
authors.forename: O
authors.initials: O
authors.lastname: Sterner
mesh_terms: D000577:Amides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D004718:Saccharomycetales / Q000187:drug effects; D013098:Xylariales / Q000737:chemistry* / Q000254:growth & development
chemical_list: D000577:Amides; D000935:Antifungal Agents; C104845:xylaramide