[An experimental study of the effect of Zofran on the manifestations of a primary reaction to irradiation].
Zofran is a selective antagonist of 5-HT3 receptors which effectively prevents postradiation dyspeptic and behavioral disorders in dogs and rats. Administration of the drug normalizes intestinal absorption and propulsion activity in irradiated animals.
Legeza
V I
VI
Shagoian
M G
MG
Kamynina
M F
MF
Lokteva
O I
OI
Turlakov
Iu S
IuS
D000818:Animals; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D004353:Drug Evaluation, Preclinical; D005260:Female; D005720:Gamma Rays; D006897:Hydroxyindoleacetic Acid / Q000097:blood / Q000528:radiation effects; D008297:Male; D017294:Ondansetron / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000150:complications / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D012701:Serotonin / Q000097:blood / Q000528:radiation effects; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D014916:Whole-Body Irradiation / Q000009:adverse effects
D011837:Radiation-Protective Agents; D012702:Serotonin Antagonists; D012701:Serotonin; D017294:Ondansetron; D006897:Hydroxyindoleacetic Acid