title: Urokinase thrombolysis as initial therapy for acute and non-acute ischemic extremities.
abstract: Limb ischemia, both acute and chronic, presents a risk to life and limb with mortality rates from 3% to 37% and amputation rates of the same range. Our experience with urokinase thrombolysis as the initial therapy for acute and non-acute ischemic extremities over 57 consecutive cases of native arterial occlusion by either thrombus or embolus has resulted in no mortality and only 3.5% requiring amputation (2 of 57). In 74% of cases initial thrombolytic therapy was followed by either balloon angioplasty (35 patients) or surgery (7 patients) to relieve the underlying cause of obstruction (i.e., stenosis, occlusion or aneurysm). Thrombolysis alone was sufficient and effective treatment in the remaining 26% (15 patients).
authors.affiliation: INOVA Health System, Fairfax Hospital, VA, USA.
authors.forename: D
authors.initials: D
authors.lastname: Byrne
authors.forename: W D
authors.initials: WD
authors.lastname: Byrne
authors.forename: P D
authors.initials: PD
authors.lastname: Kiernan
authors.forename: W
authors.initials: W
authors.lastname: Harshaw
authors.forename: J
authors.initials: J
authors.lastname: Bryne
authors.forename: T
authors.initials: T
authors.lastname: Fulcher
authors.forename: L
authors.initials: L
authors.lastname: Stanton
authors.forename: S
authors.initials: S
authors.lastname: Goodman
authors.forename: M
authors.initials: M
authors.lastname: Karnaze
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000800:Angioplasty, Balloon; D001157:Arterial Occlusive Diseases / Q000188:drug therapy*; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007511:Ischemia / Q000188:drug therapy* / Q000209:etiology / Q000628:therapy; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*; D014656:Vascular Surgical Procedures
chemical_list: D005343:Fibrinolytic Agents; D014568:Urokinase-Type Plasminogen Activator