title: Congenital absence of the uterus and vagina is not commonly transmitted as a dominant genetic trait: outcomes of surrogate pregnancies.
abstract: OBJECTIVE
  To determine the inheritance pattern of congenital absence of the uterus and vagina in affected women undergoing surrogacy IVF with this disorder.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  A hospital-based reproductive endocrinology and infertility center.
  
  
  METHODS
  Women diagnosed with congenital absence of the uterus and vagina undergoing IVF with subsequent transfer of embryos to a surrogate uterus.
  
  
  METHODS
  Questionnaires were sent to all infertility treatment centers performing surrogate procedures.
  
  
  METHODS
  Number, gender, and frequency of congenital anomalies in progeny.
  
  
  RESULTS
  Thirty-two of 53 surveyed programs responded (60%). One hundred sixty-two IVF cycles were performed, and 34 liveborn children were delivered (half female). No congenital anomalies were found, except for one male child with a middle ear defect and hearing loss.
  
  
  CONCLUSIONS
  These results strongly suggest that congenital absence of the uterus and vagina, if genetically transmitted, is not inherited commonly in a dominant fashion.
authors.affiliation: Department of Obstetrics and Gynecology, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts 02111, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Petrozza
authors.forename: M R
authors.initials: MR
authors.lastname: Gray
authors.forename: A J
authors.initials: AJ
authors.lastname: Davis
authors.forename: R H
authors.initials: RH
authors.lastname: Reindollar
mesh_terms: D000013:Congenital Abnormalities / Q000235:genetics; D004432:Ear, Middle / Q000002:abnormalities; D005260:Female; D005307:Fertilization in Vitro; D005799:Genes, Dominant; D006311:Hearing Disorders / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D013533:Gestational Carriers; D014599:Uterus / Q000002:abnormalities*; D014621:Vagina / Q000002:abnormalities*