5-HT1A receptors are not involved in clozapine's lack of cataleptogenic potential.
Clozapine and 8-OH-DPAT antagonized haloperidol-induced catalepsy in rats (ED50 10 and 0.1 mg/kg s.c., respectively). Whereas the selective 5-HT1A receptor antagonist WAY 100635 (0.1 mg/kg s.c.) completely antagonized the inhibitory effect of 8-OH-DPAT, clozapine's effect was not affected. On the other hand, clozapine and 8-OH-DPAT inhibited ultrasonic vocalization in rats (ED50 0.7 and 0.03 mg/kg s.c., respectively), which effects were antagonized by WAY 100635. The lack of catalepsy of clozapine, therefore, cannot be addressed primarily to clozapine's agonistic activity at 5-HT1A receptors.
Bartoszyk
G D
GD
Merck KGaA, Department of CNS Research, CNS Pharmacology, Darmstadt, Germany.
Roos
C
C
Ziegler
H
H
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002375:Catalepsy / Q000139:chemically induced / Q000517:prevention & control*; D003024:Clozapine / Q000494:pharmacology*; D006220:Haloperidol / Q000633:toxicity; D008297:Male; D010879:Piperazines / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D014465:Ultrasonics; D014828:Vocalization, Animal / Q000187:drug effects
D014150:Antipsychotic Agents; D010879:Piperazines; D011725:Pyridines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; C090413:N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D003024:Clozapine; D006220:Haloperidol