Maternal inheritance in Parkinson's disease.
To evaluate possible matrilineal factors in the inheritance of Parkinson's disease, we prospectively identified families in which a parent and multiple siblings had Parkinson's disease. In each of the 5 families identified, the affected parent was the mother (p < 0.03). The age at onset in the offspring generation in these 5 families was younger than the age at onset in the parental generation (p < 0.001). In addition, the age at onset in all patients with an affected mother (n = 18) was younger than the age at onset in the affected mothers (p < 0.001). No difference was found between the age at onset in patients with an affected father (n = 14) and the age at onset in the affected fathers. These results are consistent with a role for inherited abnormalities of mitochondrial DNA in the pathogenesis of at least some cases of Parkinson's disease.
Wooten
G F
GF
Department of Neurology, University of Virginia Health Sciences Center, Charlottesville 22908, USA.
Currie
L J
LJ
Bennett
J P
JP
Harrison
M B
MB
Trugman
J M
JM
Parker
W D
WD
D000328:Adult; D017668:Age of Onset; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D018811:Maternal Exposure; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*