Genes and lineages in the formation of the enteric nervous system.
The enteric nervous system is large, complex, and independent of the CNS. Its neural-crest-derived precursors migrate along defined pathways to colonize the bowel. Recent studies of the sequential actions of essential growth and transcription factors have revealed that enteric neuronal development involves a complex interaction of lineage-determined and microenvironmental elements.
Gershon
M D
MD
Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA. mdg4@columbia.edu
D000818:Animals; D002460:Cell Line; D004622:Embryo, Mammalian / Q000502:physiology; D004625:Embryo, Nonmammalian; D005314:Embryonic and Fetal Development; D005796:Genes; D007422:Intestines / Q000196:embryology* / Q000294:innervation*; D009420:Nervous System / Q000196:embryology; D009432:Neural Crest / Q000502:physiology; D013234:Stem Cells / Q000502:physiology