Lithium-induced neurotoxicity at serum lithium levels within the therapeutic range.
OBJECTIVE
To report the occurrence of lithium-induced neurotoxicity and extrapyramidal symptoms at serum lithium levels within the therapeutic range.


METHODS
On two occasions, a 73-year-old patient presented with symptoms of lithium-induced neurotoxicity and extrapyramidal symptoms when her serum lithium levels were within the therapeutic range.


RESULTS
Both lithium-induced neurotoxicity and extrapyramidal symptoms resolved when lithium was withdrawn.


CONCLUSIONS
Even when serum lithium levels are within the therapeutic range, lithium-induced neurotoxicity may occur. Patients on neuroleptics and the elderly in particular may be more vulnerable to these side effects.
Arya
D K
DK
Masterton Hospital, New Zealand.
D000368:Aged; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001480:Basal Ganglia Diseases / Q000209:etiology; D003866:Depressive Disorder / Q000188:drug therapy / Q000523:psychology; D005260:Female; D006801:Humans; D016651:Lithium Carbonate / Q000009:adverse effects* / Q000097:blood* / Q000627:therapeutic use
D000928:Antidepressive Agents; D016651:Lithium Carbonate