title: Infection after open reduction and internal fixation with dynamic compression plates--clinical and experimental data.
abstract: Infection rates for open reduction and internal fixation (ORIF) with the DCP in clinical studies are based on heterogeneous data on general risk factors and do not take into account the direct effect of the implant (material, design, surface, technique). The initial degree of bacterial contamination is generally unknown and the applied definition of the term infection is not mentioned. In our own prospective randomized clinical study including 281 cases of ORIF with the DCP (154 steel vs 127 titanium), the influence of the implant material on susceptibility to local infection was examined in relation to initial bacteria contamination (109 non-contaminated / 172 contaminated). Although in the group of contaminated DCPs the difference in the infection rates for stainless steel (sSt) and commercially pure titanium (cpTi) showed no statistical significance, a tendency was apparent. In an animal experiment, the lower rates of infection for c.p.Ti-DCP compared to sSt-DCP in the presence of a local bacterial challenge could be demonstrated with statistical significance. The need for further experimental research in the field of implant related local infection after ORIF will be discussed and strategies for further investigations proposed.
authors.affiliation: AO/ASIF Research Institute, Davos, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Arens
authors.forename: M
authors.initials: M
authors.lastname: Hansis
authors.forename: U
authors.initials: U
authors.lastname: Schlegel
authors.forename: H
authors.initials: H
authors.lastname: Eijer
authors.forename: G
authors.initials: G
authors.lastname: Printzen
authors.forename: W J
authors.initials: WJ
authors.lastname: Ziegler
authors.forename: S M
authors.initials: SM
authors.lastname: Perren
mesh_terms: D000818:Animals; D005593:Fracture Fixation, Internal / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D011446:Prospective Studies; D019736:Prostheses and Implants / Q000009:adverse effects*; D011817:Rabbits; D011897:Random Allocation; D012307:Risk Factors; D013193:Stainless Steel / Q000009:adverse effects; D013530:Surgical Wound Infection / Q000209:etiology* / Q000382:microbiology; D014025:Titanium / Q000009:adverse effects
chemical_list: D013193:Stainless Steel; D014025:Titanium