[Development of a new statistical evaluation method for brain SPECT images].
The purpose of this study was to develop a new statistical evaluation method for Brain SPECT images. First, we made normal brain image databases using 99mTc-ECD and SPECT in 10 normal subjects as described previously. Each SPECT images were globally normalized and anatomically standardized to the standard brain shape using Human Brain Atlas (HBA) of Roland et al. and each subject's X-CT. Then, mean and SD images were calculated voxel by voxel. For the next step, 99mTc-ECD SPECT images of a patient were obtained, and global normalizing and anatomical standardization were performed as the same way. Then, a statistical map was calculated as following voxel by voxel; (P-Mean)/SD x 10 + 50, where P, Mean and SD indicate voxel value of patient, mean and SD images of normal databases, respectively. We found this statistical map was helpful for clinical diagnosis of brain SPECT studies.
Kawashima
R
R
Department of Nuclear Medicine and Radiology, IDAC, Tohoku University.
Sato
K
K
Ito
H
H
Koyama
M
M
Goto
R
R
Yoshioka
S
S
Ono
S
S
Sato
T
T
Fukuda
H
H
D001921:Brain / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D003545:Cysteine / Q000031:analogs & derivatives*; D003627:Data Interpretation, Statistical; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D015899:Tomography, Emission-Computed, Single-Photon
D015609:Organotechnetium Compounds; C059659:technetium Tc 99m bicisate; D003545:Cysteine