title: Oxysporidinone: a novel, antifungal N-methyl-4-hydroxy-2-pyridone from Fusarium oxysporum.
abstract: Oxysporidinone (1), a novel 3,5-disubstituted N-methyl-4-hydroxy-2-pyridone, was isolated from fermentations of Fusarium oxysporum (CBS 330.95) by counter-current chromatography. The structure was determined by spectroscopic methods including NMR, MS, IR, and UV analysis. Oxysporidinone exhibited growth inhibitory activity against several common plant pathogenic fungi.
authors.affiliation: Novo Nordisk A/S, Bagsvaerd, Denmark. jbre@novo.dk
authors.forename: J
authors.initials: J
authors.lastname: Breinhold
authors.forename: S
authors.initials: S
authors.lastname: Ludvigsen
authors.forename: B R
authors.initials: BR
authors.lastname: Rassing
authors.forename: C N
authors.initials: CN
authors.lastname: Rosendahl
authors.forename: S E
authors.initials: SE
authors.lastname: Nielsen
authors.forename: C E
authors.initials: CE
authors.lastname: Olsen
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D005670:Fusarium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D011728:Pyridones / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000935:Antifungal Agents; D011728:Pyridones; C104552:oxysporidinone