title: Effect of early treatment with praziquantel on serum connective tissue metabolite markers in children and adolescents with intestinal schistosomiasis mansoni.
abstract: This work was designed to assess the reflection of early treatment by praziquantel (CAS 55268-74-1, EMBAY 8440, Biltricide) on serum connective tissue metabolite markers (hyaluronic acid and procollagen III peptide) in patients with active intestinal schistosomiasis. Children and adolescent subjects from primary and secondary schools in an endemic area of schistosomiasis mansoni were included. Age-matched subjects from an urban area served as normal controls. All subjects were examined clinically and parasitologically. Detection of hepatitis B seromarkers was also done. The infected subjects were treated with praziquantel at a dose of 60 mg/kg of body weight which was repeated after 4 weeks. Serum hyaluronic acid and procollagen III peptide were measured by radioimmunoassay. High hyaluronic acid was encountered in infected subjects when compared to their respective age-matched controls. Significant decrease of 4 and 8 weeks post-treatment was noted when compared to ist level before treatment. There was no significant change in serum procollagen III peptide on comparing infected subjects to their controls, whereas a significant increase was observed in its level after 4 and 8 weeks post-treatment compared to that before treatment. This work suggests that early treatment of intestinal schistosomiasis with specific chemotherapy (praziquantel) decreases serum hyaluronic acid and increases procollagen III peptide probably via downregulation of granulomatous inflammatory cell reaction and activation of collagenase enzymes, respectively.
authors.affiliation: Theodor Bilharz Research Institute (TBRI), Imbaba, Guiza (Egypt).
authors.forename: H I
authors.initials: HI
authors.lastname: Hassanein
authors.forename: M M
authors.initials: MM
authors.lastname: Zoheiry
authors.forename: B
authors.initials: B
authors.lastname: Voss
authors.forename: G M
authors.initials: GM
authors.lastname: el Attar
authors.forename: S I
authors.initials: SI
authors.lastname: Hassan
authors.forename: Z A
authors.initials: ZA
authors.lastname: Demerdash
authors.forename: H M
authors.initials: HM
authors.lastname: el Baz
authors.forename: O A
authors.initials: OA
authors.lastname: Yousif
mesh_terms: D000293:Adolescent; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D000947:Antigens, Helminth / Q000032:analysis; D015415:Biomarkers; D002648:Child; D003238:Connective Tissue / Q000378:metabolism*; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism; D011223:Praziquantel / Q000627:therapeutic use*; D011347:Procollagen / Q000378:metabolism; D011863:Radioimmunoassay; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000378:metabolism*
chemical_list: D000871:Anthelmintics; D000947:Antigens, Helminth; D015415:Biomarkers; D011347:Procollagen; D011223:Praziquantel; D006820:Hyaluronic Acid