Cushing's syndrome secondary to ectopic ACTH secretion from a primary ovarian carcinoma.
We report a 63-year-old woman who presented with clinical and biochemical features of ACTH dependent Cushing's syndrome secondary to a primary ovarian carcinoma. The tumour produced very high levels of ACTH precursors, consistent with defective POMC processing.
Ball
S G
SG
Department of Obstetrics and Gynaecology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Davison
J M
JM
Burt
A D
AD
McNicol
A M
AM
Baylis
P H
PH
D000182:ACTH Syndrome, Ectopic / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D000324:Adrenocorticotropic Hormone / Q000032:analysis; D002277:Carcinoma / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D003480:Cushing Syndrome / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D011333:Pro-Opiomelanocortin / Q000378:metabolism
D011333:Pro-Opiomelanocortin; D000324:Adrenocorticotropic Hormone