Uterine epithelioid leiomyosarcoma in a pig-tailed macaque.
During ultrasonographic examination following spontaneous abortion, an approximately 6-cm diameter mass of mixed echogenicity is detected in the uterine wall of a mature pig-tailed macaque (Macaca nemestrina). Grossly, the mass is associated with the uterine fundus, multilobulate and tan with red-black mottled foci on cut surface. Microscopically, the invasive mass is composed of poorly differentiated round cells arranged in sheets and bundles supported by a fine fibrous stroma. On immunohistochemical evaluation, neoplastic cells contain vimentin, desmin, muscle actin, and smooth muscle alpha-actin antigens and do not react with antibodies to low and high molecular-weight cytokeratins. Cell morphology and immunohistochemical results indicate a diagnosis of epithelioid leiomyosarcoma (clear cell variant).
Birkebak
T A
TA
Department of Comparative Medicine, University of Washington, Seattle 98195-7190, USA.
Wang
N P
NP
Weyhrich
J
J
D000034:Abortion, Veterinary; D000818:Animals; D005260:Female; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D008254:Macaca nemestrina; D008992:Monkey Diseases / Q000175:diagnosis* / Q000473:pathology; D011247:Pregnancy; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*