Nucleation mechanisms in protein folding.
Experiment and theory are converging on the importance of nucleation mechanisms in protein folding. These mechanisms do not use classic nuclei, which are well formed elements of structure present in ground states, but they use diffuse, extended regions, which are observed in transition states.
Fersht
A R
AR
Cambridge University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK. ARF10@cam.ac.uk
D007700:Kinetics; D011487:Protein Conformation; D017510:Protein Folding