Origin, maturation and antigen presenting function of dendritic cells.
Dendritic cells are cells specialized for antigen capture, migration and T cell stimulation. Recent advances have been made in understanding their origin, their heterogeneity, the mechanism of antigen uptake, and the signals that induce their migration and maturation into immunostimulatory antigen-presenting cells. Dendritic cells represent the natural adjuvants for T cell responses and their therapeutic exploitation in the near future is foreseen.
Cella
M
M
Basel Institute for Immunology, Grenzacherstrasse 487, CH4005 Basel, Switzerland.
Sallusto
F
F
Lanzavecchia
A
A
D000818:Animals; D017951:Antigen Presentation; D002454:Cell Differentiation / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology* / Q000276:immunology*; D006801:Humans