Effect of Gamma Knife radiosurgery on acoustic neurinomas. Assessment by 99mTc-DTPA-human serum albumin- and 201TlCl-single photon emission computed tomography.
Single photon emission computed tomography (SPECT) was performed on 16 patients with acoustic neurinoma before and 1 and 2 years after Gamma Knife surgery. 201TICI-SPECT was used to determine tumor viability. Early and delayed images of 99mTc-DTPA-human serum albumin (99mTc-HSA-D)-SPECT were used to assess tumor vascularity and permeability, respectively. There was a statistically significant decrease in the 99mTc-HSA-D index of the early image at 1 year (p = 0.013) and at 2 years (p = 0.018) after Gamma Knife surgery. On the other hand, the 201Tl index and the 99mTc-HSA-D index of the delayed image were not significantly different from their pretreatment values. These observations demonstrate that a reduction in tumor vascularity without a decrease in tumor viability may be one of the effects of Gamma Knife surgery on acoustic neurinomas.
Seo
Y
Y
Department of Neurosurgery, Nakamura Memorial Hospital, Hokkaido Brain Research Foundation, Sapporo, Japan.
Fukuoka
S
S
Nakagawara
J
J
Takanashi
M
M
Takahashi
S
S
Suematsu
K
K
Nakamura
J
J
D000328:Adult; D000368:Aged; D003390:Cranial Nerve Neoplasms / Q000098:blood supply / Q000601:surgery*; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000098:blood supply / Q000601:surgery*; D010539:Permeability; D016634:Radiosurgery; D013668:Technetium Tc 99m Aggregated Albumin; D016284:Technetium Tc 99m Pentetate; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D016896:Treatment Outcome
D013668:Technetium Tc 99m Aggregated Albumin; D013794:Thallium Radioisotopes; C057162:technetium Tc 99m DTPA HSA; D016284:Technetium Tc 99m Pentetate