title: Loss of basic fibroblast growth factor in the subcommissural organ of old spontaneously hypertensive rats.
abstract: The immunocytochemical localization of basic fibroblast growth factor (bFGF) was studied in subcommissural organ (SCO) of aged-matched normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SH) rats at 10, 14 and 18 months of age using a polyclonal antibody against bFGF. The bFGF-like immunoreactivity (bFGF-ir) was observed in SCO ependymal cells of young and old normotensive rats. However, a progressive loss of bFGF-immunopositive ependymal SCO cells was observed with age in SH rats (27.24, 57.5 and 96.9% in 10, 14 and 18 months old respectively) compared with aged-matched WKY normotensive rats. Considering the potential role of the SCO in sleep regulation and sodium homeostasis, which are altered in essential hypertension, these data show a new neuroendocrine anomaly to be added to the many others previously observed in this rat strain, when they develop hypertension as they get old.
authors.affiliation: Servicio de Histología, Hospital Universitario Ramón y Cajal, Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Cuevas
authors.forename: D
authors.initials: D
authors.lastname: Reimers
authors.forename: G
authors.initials: G
authors.lastname: Giménez-Gallego
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002452:Cell Count; D002552:Cerebral Ventricles / Q000737:chemistry; D004805:Ependyma / Q000737:chemistry / Q000166:cytology; D016222:Fibroblast Growth Factor 2 / Q000032:analysis / Q000378:metabolism*; D007150:Immunohistochemistry; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013351:Subcommissural Organ / Q000737:chemistry / Q000378:metabolism*
chemical_list: D016222:Fibroblast Growth Factor 2