Is TNF really involved in cachexia?
A review on the possible involvement of tumor necrosis factor-alpha (TNF) in cachexia is presented. While this cytokine is definitely linked to sepsis and tumor-associated weight loss in some experimental models, other cytokines, such as interleukin-6 (IL-6) or interferon-gamma (IFN-gamma), alone or in combination with TNF, may also play an important role in the development of cachexia.
García-Martínez
C
C
Department of Biochemistry and Physiology, Facultat de Biologia, Universitat de Barcelona, Spain.
Costelli
P
P
López-Soriano
F J
FJ
Argilés
J M
JM
D000818:Animals; D002100:Cachexia / Q000209:etiology / Q000276:immunology*; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
D014409:Tumor Necrosis Factor-alpha