title: Mutations at codon 974 of the DPYD gene are a rare event.
abstract: A mutation at codon 974 of the dihydropyrimidine dehydrogenase (DPD) gene was previously described in a cancer patient with undetectable DPD enzyme activity who experienced severe toxicity when treated with 5-fluorouracil. We have studied the frequency of this mutation in 29 Scottish subjects with low DPD enzyme activity and in 274 American subjects. We detected no mutations in the 606 alleles studied and conclude that mutations at codon 974 are a rare event.
authors.affiliation: Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, UK.
authors.forename: S A
authors.initials: SA
authors.lastname: Ridge
authors.forename: O
authors.initials: O
authors.lastname: Brown
authors.forename: J
authors.initials: J
authors.lastname: McMurrough
authors.forename: P
authors.initials: P
authors.lastname: Fernandez-Salguero
authors.forename: W E
authors.initials: WE
authors.lastname: Evans
authors.forename: F J
authors.initials: FJ
authors.lastname: Gonzalez
authors.forename: H L
authors.initials: HL
authors.lastname: McLeod
mesh_terms: D042943:Dihydrouracil Dehydrogenase (NADP); D005787:Gene Frequency; D006801:Humans; D010088:Oxidoreductases / Q000235:genetics*; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D010088:Oxidoreductases; D042943:Dihydrouracil Dehydrogenase (NADP)