[The role of thromboxane in the pathogenesis of nephropathies].
Impaired haemostasis, in particular aggregation in renal disease stimulated research of its prevention and treatment. The achieved results are a significant contribution not only to theoretical research but also to its application in nephrological practice. The submitted review presents specific features of nephrological patients ensuing from overproduction of prostaglandins, in particular thromboxane, by renal cells, focused on glomeruli where mesangial and epithelial cells participate in prostaglandin production and where thromboxane is associated with hyperfiltrations, proliferation, aggregation and other processes damaging glomeruli.
Dzúrik
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R
Klinika farmakoterapie Ustavu preventívnej a klinickej medicíny, Bratislava.
Krivosíková
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Z
Spustová
V
V
D000818:Animals; D006487:Hemostasis; D006801:Humans; D007668:Kidney / Q000502:physiology / Q000503:physiopathology; D007674:Kidney Diseases / Q000097:blood / Q000503:physiopathology*; D013931:Thromboxanes / Q000502:physiology*
D013931:Thromboxanes