title: Dual dynamic contrast-enhanced MR imaging.
abstract: A method was devised for obtaining dynamic contrast-enhanced T1-weighted and relaxation rate (delta R2*) images simultaneously to evaluate regional hemodynamics of the brain tumors. On a 1.5-T MR system, dual dynamic contrast-enhanced images were obtained using a gradient echo (dual echo fast field echo) pulse sequence with the keyhole technique to improve temporal and spatial resolution during a rapid bolus injection of gadopentetate dimeglumine. The dynamic T1 contrast images were obtained from the first echo: moreover. integral delta R2*dt values were calculated from the first and the second echo images. The dynamic T1 contrast images provided information about characteristic enhancement pattern (vascularization and disruption of blood-brain barrier), and the integral delta R2*dt values provided a map of regional blood pool in tumor site, peritumoral edema, and other surrounding regions of the brain. The ability to obtain dynamic contrast-enhanced T1 contrast and delta R2* imaging at the same time allows optimization of the advantages of each and thereby more information about the microvascular circulation of the brain lesions.
authors.affiliation: Department of Central Radiology, Nagoya City University Hospital, Alchi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miyati
authors.forename: T
authors.initials: T
authors.lastname: Banno
authors.forename: M
authors.initials: M
authors.lastname: Mase
authors.forename: H
authors.initials: H
authors.lastname: Kasai
authors.forename: H
authors.initials: H
authors.lastname: Shundo
authors.forename: M
authors.initials: M
authors.lastname: Imazawa
authors.forename: S
authors.initials: S
authors.lastname: Ohba
mesh_terms: D001921:Brain / Q000473:pathology*; D001932:Brain Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000473:pathology; D003287:Contrast Media; D003937:Diagnosis, Differential; D006439:Hemodynamics; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D012680:Sensitivity and Specificity; D013120:Spinal Cord Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000473:pathology
chemical_list: D003287:Contrast Media