title: Superoxide dismutase activity and lipid peroxidation in the liver of guinea pig infected with Leptospira interrogans.
abstract: Superoxide dismutase (SOD) activity and the degree of lipid peroxidation were studied over a two week period in guinea pigs infected with Leptospira interrogans derived from wild mice. The total SOD activity in infected host liver increased by four-fold two days after infection; this was followed by a 20% decrease resulting in levels comparable to normal, uninfected liver. During the period of decreasing SOD activity after day two, the levels of TBA-reactive material (TBARS) are increased by three-fold in infected guinea pig, liver, compared to uninfected liver. The results indicate that SOD attenuates intracellular superoxide-mediated toxic effects in guinea pigs infected with L. interrogans. In addition, electron microscopy structure demonstrates correlated pathogenic shrinkage of mitochondrial and Kupffer cell structures.
authors.affiliation: Department of Biological Science, College of Natural Sciences, Chosun University, Kwangju, Korea.
authors.forename: Y G
authors.initials: YG
authors.lastname: Kim
authors.forename: D Y
authors.initials: DY
authors.lastname: Jeon
authors.forename: M K
authors.initials: MK
authors.lastname: Yang
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D015227:Lipid Peroxidation; D008099:Liver / Q000201:enzymology* / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008854:Microscopy, Electron; D013482:Superoxide Dismutase / Q000378:metabolism*; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D014895:Weil Disease / Q000201:enzymology* / Q000473:pathology
chemical_list: D017392:Thiobarbituric Acid Reactive Substances; D013482:Superoxide Dismutase