Malignancy after retinoblastoma: secondary cancer or recurrence?
The risk of second malignancy after retinoblastoma is reported to be as high as 20% at 10 years after initial diagnosis. This incidence may be an overestimate because of difficulties in distinguishing a second malignancy from recurrent tumor. We encountered a patient with bilateral retinoblastoma who developed a temporal mass 3.5 years after initial treatment for what had first been diagnosed as rhabdomyosarcoma; further study suggested that it was recurrent retinoblastoma manifesting as primitive neuroectodermal tumor (PNET) with multilineage differentiation. Chromosome 13 abnormalities were compatible with either rhabdomyosarcoma or recurrent retinoblastoma. To determine how often second malignancies in retinoblastoma patients may be confused with recurrent primary tumor, we reviewed our experience at Children's Hospital of Pittsburgh. Of 43 retinoblastoma patients seen between 1951 and 1992, presumed second malignancies were documented in four, including the current case. Of the three other second tumors, one had both neural and skeletal muscle differentiation; another was diagnosed as rhabdomyosarcoma unclassifiable as embryonal or alveolar; the last was an osteosarcoma. Only the osteosarcoma was clearly a second neoplasm; two and perhaps three of the other cases may be recurrent retinoblastoma. The distinction between second malignancy and recurrent retinoblastoma may be difficult but is worth determining, because treatment may differ, depending on the correct designation.
Dickman
P S
PS
Department of Pathology, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, PA 15213, USA.
Barmada
M
M
Gollin
S M
SM
Blatt
J
J
D002871:Chromosome Banding; D003582:Cytogenetics; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D003937:Diagnosis, Differential; D017629:Gap Junctions / Q000648:ultrastructure; D006801:Humans; D007223:Infant; D008854:Microscopy, Electron; D008870:Microtubules / Q000648:ultrastructure; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000648:ultrastructure; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000648:ultrastructure; D012175:Retinoblastoma / Q000175:diagnosis* / Q000648:ultrastructure; D012189:Retrospective Studies; D012509:Sarcoma / Q000175:diagnosis* / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000648:ultrastructure