Sumatriptan decreases food intake and increases plasma growth hormone in healthy women.
We studied the effect of the 5-HT1B/ID receptor agonist sumatriptan (6 mg s.c.) on plasma growth hormone and prolactin and food intake in 15 healthy female subjects using a double-blind, placebo-controlled, cross-over design. Sumatriptan significantly elevated plasma growth hormone but did not alter plasma prolactin. Sumatriptan also significantly lowered total food intake in a buffet meal, particularly decreasing the intake of fat. Our results indicate that 5-HT1B/ID receptors may be involved in the regulation of food intake in humans. In addition, while activation of 5-HT1B/ID receptors stimulates growth hormone release in both men and women, sumatriptan lowers plasma prolactin only in men, suggesting sex differences in the 5-HT regulation of prolactin release.
Boeles
S
S
University Department of Psychiatry, Littlemore Hospital, Oxford, UK.
Williams
C
C
Campling
G M
GM
Goodall
E M
EM
Cowen
P J
PJ
D000328:Adult; D018592:Cross-Over Studies; D004435:Eating / Q000187:drug effects*; D005260:Female; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D009325:Nausea / Q000139:chemically induced; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D018170:Sumatriptan / Q000494:pharmacology*
D017366:Serotonin Receptor Agonists; D019382:Human Growth Hormone; D018170:Sumatriptan