Evolution of left ventricular hypertrophy and function during long-term treatment of systemic hypertension with enalapril.
Continued treatment of hypertensive patients with enalapril reduced left ventricular (LV) hypertrophy steadily over a period of 5 years (by which time gross structural parameters were normal) and produced no further reduction during the following 2 years. Temporary suspension of treatment after 5-year follow-up gave rise to an increase in blood pressure, and to deterioration of LV isovolumic relaxation time and deceleration of the ventricular filling E wave, both of which chiefly reflect the active relaxation of the ventricle.
González-Juanatey
J R
JR
Cardiology Department and Hypertension Unit, Complejo Hospitalario Universitario, La Coruna, Spain.
Pose Reino
A
A
Román
A V
AV
García Acuña
J M
JM
Fernández López
J A
JA
Cerrato
J C
JC
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D015150:Echocardiography, Doppler; D004656:Enalapril / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000187:drug effects*
D000959:Antihypertensive Agents; D004656:Enalapril