title: Exclusion of linkage between schizophrenia and the gene encoding a neutral amino acid glutamate/aspartate transporter, SLC1A5.
abstract: An abnormality in glutamatergic function has been hypothesized as being of etiological importance in schizophrenia. Twenty-three multiplex English and Icelandic schizophrenia families were genotyped with a polymorphic dinucleotide repeat sequence in the 3'-untranslated region of the glutamate/aspartate transporter gene called SLC1A5. Using the lod and a model-free method of linkage analysis (MFLINK), no evidence of linkage between SLC1A5 and schizophrenia was found. Our results do not support the hypothesis that SLC1A5 gene mutations or allelic variants provide a major gene contribution to the etiology of schizophrenia. However, because of the likelihood of heterogeneity of linkage in schizophrenia, there is a case for testing other pedigrees for linkage to the SLC1A5 locus. The SLC1A5 locus is one of a complex family of genes encoding neutral amino acid transporter proteins and the genetic relation between these other loci and schizophrenia has not yet been established.
authors.affiliation: Department of Psychiatry, University College London Medical School, UK.
authors.forename: A C
authors.initials: AC
authors.lastname: Chen
authors.forename: G
authors.initials: G
authors.lastname: Kalsi
authors.forename: J
authors.initials: J
authors.lastname: Brynjolfsson
authors.forename: T
authors.initials: T
authors.lastname: Sigmundsson
authors.forename: D
authors.initials: D
authors.lastname: Curtis
authors.forename: R
authors.initials: R
authors.lastname: Butler
authors.forename: T
authors.initials: T
authors.lastname: Read
authors.forename: P
authors.initials: P
authors.lastname: Murphy
authors.forename: E A
authors.initials: EA
authors.lastname: Barnard
authors.forename: H
authors.initials: H
authors.lastname: Petursson
authors.forename: H M
authors.initials: HM
authors.lastname: Gurling
mesh_terms: D000483:Alleles; D027322:Amino Acid Transport System X-AG; D002352:Carrier Proteins / Q000235:genetics*; D004739:England; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D007055:Iceland; D008126:Lod Score; D008297:Male; D010375:Pedigree; D016133:Polymerase Chain Reaction; D011995:Recombination, Genetic; D012559:Schizophrenia / Q000235:genetics* / Q000378:metabolism; D012984:Software
chemical_list: D027322:Amino Acid Transport System X-AG; D002352:Carrier Proteins; D005819:Genetic Markers; D006023:Glycoproteins