title: Large amounts of polyethylene debris in the interface tissue surrounding bipolar endoprostheses. Comparison to total hip prostheses.
abstract: A histologic and biochemical comparison of interface membranes around femoral components of bipolar endoprostheses (n = 17) and total hip prostheses (n = 17) inserted without cement was conducted. The patients' profiles were similar in both groups with respect to age, sex, primary diagnosis, weight, and the interval between primary and revision arthroplasty. Macroscopically, marked circumferential abrasion of the polyethylene insert in the retrieved bipolar cups was noted. Histologic analysis revealed significantly larger amounts of polyethylene debris in the bipolar group. The membranes from the bipolar group also produced significantly greater amounts of prostaglandin E2 (P < .05). The inflammatory membranes associated with large amounts of polyethylene debris may have contributed to aseptic loosening and osteolysis in patients with a bipolar hip prosthesis.
authors.affiliation: Department of Orthopaedic Surgery, University of Pittsburgh, Pennsylvania, USA.
authors.forename: K J
authors.initials: KJ
authors.lastname: Kim
authors.forename: H E
authors.initials: HE
authors.lastname: Rubash
mesh_terms: D017364:Collagenases / Q000032:analysis; D015232:Dinoprostone / Q000032:analysis; D005260:Female; D005272:Femur Neck / Q000737:chemistry / Q000473:pathology; D005549:Foreign-Body Reaction / Q000209:etiology* / Q000473:pathology; D015743:Giant Cells, Foreign-Body / Q000473:pathology; D006621:Hip Joint / Q000473:pathology; D006622:Hip Prosthesis / Q000009:adverse effects*; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010014:Osteolysis / Q000209:etiology / Q000473:pathology; D011095:Polyethylenes; D011474:Prosthesis Design; D011475:Prosthesis Failure; D012086:Reoperation; D013583:Synovial Membrane / Q000737:chemistry / Q000473:pathology*
chemical_list: D007375:Interleukin-1; D011095:Polyethylenes; D017364:Collagenases; D015232:Dinoprostone