Antigen stimulation of human pulmonary smooth muscle: an in vitro model of inflammation.
Human airways in vitro contract when stimulated by anti-IgE, whereas human pulmonary vessels relax. Leukotriene D4 (LTD4) induced a contractile response in the airways, while in pulmonary vessels both contractions and relaxations were observed. The LTD4 contractions in airways were blocked by cysLT1 receptor antagonists (MK 571, ICI 198615, and BAY x7195). In contrast none of the compounds affected the LTD4 contractions of pulmonary veins. These results suggest that the leukotrienes which are released during antigen challenge of airways and pulmonary vessels may be acting at distinct receptors in the human lung.
Gorenne
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I
CNRS URA 1159, Centre Chirurgical Marie Lannelongue, Le Plessis-Robinson, France.
Labat
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Gascard
J P
JP
Brink
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C
D000941:Antigens / Q000494:pharmacology*; D001249:Asthma / Q000276:immunology* / Q000473:pathology*; D001980:Bronchi / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D001993:Bronchodilator Agents / Q000494:pharmacology; D002469:Cell Separation; D006801:Humans; D006880:Hydroxy Acids / Q000494:pharmacology; D007191:Indazoles / Q000494:pharmacology; D017998:Leukotriene D4 / Q000037:antagonists & inhibitors / Q000494:pharmacology; D009130:Muscle, Smooth / Q000187:drug effects / Q000276:immunology*; D009638:Norepinephrine / Q000494:pharmacology; D011422:Propionates / Q000494:pharmacology; D011667:Pulmonary Veins / Q000187:drug effects; D011804:Quinolines / Q000494:pharmacology
D000941:Antigens; D001993:Bronchodilator Agents; D006880:Hydroxy Acids; D007191:Indazoles; D011422:Propionates; D011804:Quinolines; C054217:ICI 198615; C059141:verlukast; D017998:Leukotriene D4; C092294:BAY x 7195; D009638:Norepinephrine