[The pattern of predisposition to rheumatism].
The present study was based on the results of many-year studies of the Mongoloid populations the Tofalars (793 and 661 persons in 1973 and 1984, respectively), the Dolgans (n = 952) the Taimyr Yakuts (n = 452), the Todji Tuvins (n = 819) and a sample from 200 families of rheumatic patients in Moscow and Moscow Region. The interpopulation gene differentiation expressed through the generalized genetic distance (8) and the prevalence of rheumatism correlated (r = 0.63). There was also a correlation between the mean heterozygocity of the populations and the spread of rheumatism-the determination rate was 72%. Therefore, structural features of the populations have a definite impact on the prevalence of rheumatism and suggest that there is a genetic component in the determination of the disease. A segregative analysis indicated the adequacy of a multifactorial model for the majority of the studied populations, the contribution of a genetic component to the determination of varying susceptibility to rheumatism ranged from 71% in the population of the Tofalars to 100% in the populations of the Dolgans and the Tuvins. The results of testing the type of rheumatism inheritance using a SAL-2 model, the data of a regression analysis of susceptibility heritability and inbreedity of the populations, and a component resolution of phenotypic dispersion of susceptibility are indicative of its involvement, along with an additive component, in the determination of rheumatism. Clinical and genetic findings also suggest that there is a genetic heterogeneity both of rheumatism as a whole (verified +likely) and verified rheumatism (without and with cardiac diseases).
Miakotkin
V A
VA
Institute of Rheumatology, RAMN, Moscow.
D044466:Asian People; D005260:Female; D006801:Humans; D008297:Male; D009031:Moscow / Q000208:ethnology; D010375:Pedigree; D010641:Phenotype; D015995:Prevalence; D012189:Retrospective Studies; D012216:Rheumatic Diseases / Q000208:ethnology* / Q000235:genetics; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology