title: High stroke volume para-aortic counterpulsation device versus centrifugal pump in cardiogenic shock: experimental study.
abstract: During the last decades a number of left ventricular assist devices has been used especially for patients resistant to pharmacologic treatment and to intraaortic balloon pump (IABP) support for left ventricular failure. A high stroke volume para-aortic counterpulsation device (PACD) has been developed utilizing the principle of the diastolic counterpulsation technique. In this study the hemodynamic effects of the valveless PACD were compared to those of the centrifugal blood pump (CBP) in nine dogs in acute experimental cardiogenic shock. Hemodynamic measurements were obtained at baseline with both devices off, PACD on and CBP off, or PACD off and CBP on. There was no difference in mean aortic pressure between PACD on (60.0 +/- 11.5 mmHg) and CBP on (69.0 +/- 26.8 mmHg). Similarly, there was no difference in left ventricular end-diastolic pressure with the PACD on (11.9 +/- 5.4 mmHg) versus the CBP on (9.9 +/- 5.2 mmHg) or the cardiac index with the PACD on (84 +/- 36 ml/kg/min) versus the CBP on (77 +/- 36 ml/kg/min). However, the left ventricular systolic pressure (55.0 +/- 19.0 with PACD versus 73.0 +/- 26.0 with CBP,p < 0.001), the tension time index (712 +/- 381 versus 1333 +/- 694,p < 0.01), and the double product (5629 +/- 2574 versus 7440 +/- 3294,p < 0.01) were significantly lower during assistance with the PACD than with the CBP. It was concluded that PACD is at least as effective as CBP for restoring hemodynamic status during acute experimental cardiogenic shock. Moreover, the PACD unloads the left ventricle more effectively than CBP, making it suitable for left ventricular mechanical support in cases with reversible myocardial damage.
authors.affiliation: Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Vas. Sofias 80 & K. Lourou, Athens 11518, Greece.
authors.forename: S N
authors.initials: SN
authors.lastname: Nanas
authors.forename: J N
authors.initials: JN
authors.lastname: Nanas
authors.forename: C E
authors.initials: CE
authors.lastname: Charitos
authors.forename: A
authors.initials: A
authors.lastname: Gougoulakis
authors.forename: K
authors.initials: K
authors.lastname: Makaritsis
authors.forename: J
authors.initials: J
authors.lastname: Chatzigeorgiou
authors.forename: K
authors.initials: K
authors.lastname: Moussoutzani
authors.forename: M I
authors.initials: MI
authors.lastname: Anastasiou-Nana
authors.forename: S D
authors.initials: SD
authors.lastname: Moulopoulos
mesh_terms: D000818:Animals; D015908:Counterpulsation / Q000295:instrumentation*; D004285:Dogs; D004867:Equipment Design; D006439:Hemodynamics / Q000502:physiology; D007423:Intra-Aortic Balloon Pumping / Q000295:instrumentation*; D012770:Shock, Cardiogenic / Q000628:therapy*; D013318:Stroke Volume / Q000502:physiology