title: [Treatment of juvenile myoclonic epilepsy with low-dose sodium valproate].
abstract: Eleven patients with Juvenile Myoclonic Epilepsy were treated using small doses of a sustained-release form of valproic acid (500 mg/day). This treatment has lasted for an average of 33 months (8-69) and has been continued in all of the patients. None of them has experienced a new generalized tonic-clonic seizure. The myoclonias have become considerably less frequent and less intense. No side-effects have been spontaneously reported by the group of patients. Thus, we suggest to start newly diagnosed patients on small doses of valproic acid.
authors.affiliation: Clinique Neurologique, CHU Bretonneau, Tours.
authors.forename: B
authors.initials: B
authors.lastname: De Toffol
authors.forename: A
authors.initials: A
authors.lastname: Autret
mesh_terms: D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004831:Epilepsies, Myoclonic / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014635:Valproic Acid / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid