title: Retinoblastoma protein in growth suppression and death protection.
abstract: Puzzling new information indicates an inadequacy in our understanding of the retinoblastoma protein (RB). RB and the transcription factor E2F appear to be collaborators. RB-E2F interaction is necessary but not sufficient for growth suppression. Unbecoming of a tumor suppressor, RB has an active role in antagonizing the death response. How RB integrates its multiple functions into a tumor suppression program is still an open issue.
authors.affiliation: Department of Biology, University of California, San Diego 9500 Gilman Drive, La Jolla, California 92093-0347, USA. jywang@ucsd.edu
authors.forename: J Y
authors.initials: JY
authors.lastname: Wang
mesh_terms: D000818:Animals; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D016923:Cell Death / Q000502:physiology*; D002455:Cell Division / Q000502:physiology*; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D006801:Humans; D016160:Retinoblastoma Protein / Q000502:physiology*; D056465:Retinoblastoma-Binding Protein 1; D050680:Transcription Factor DP1; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D016160:Retinoblastoma Protein; D056465:Retinoblastoma-Binding Protein 1; D050680:Transcription Factor DP1; D014157:Transcription Factors