Margarine intake and risk of nonfatal acute myocardial infarction in Italian women.
OBJECTIVE
Since a relation between trans-fatty acids and cardiovascular diseases has been described, we examined the relationship between margarine intake and nonfatal acute myocardial infarction (AMI) in Italian women.


METHODS
Hospital-based case-control study.


METHODS
Northern Italy between 1983 and 1992.


METHODS
Cases were 429 women, aged 18-74 y, in hospital with diagnosis of AMI and 866 controls in hospital for acute, non-cardiovascular, non-neoplastic, non-digestive, non-hormone-related conditions.


METHODS
Odds ratios (OR), with their 95% confidence intervals (CI), were computed by unconditional multiple logistic regression analysis, including terms for age, education, body mass index, smoking, alcohol and coffee drinking, menopausal status, hormone replacement therapy and history of diabetes, hypertension and hyperlipidemia.


RESULTS
Medium or high intake of margarine was associated with an increased risk of AMI (multivariate OR 1.5, 95% CI 1.0-2.2). Analysis in separate strata of covariates indicated that the association was independent of body mass index, history of hypertension and hyperlipidemia, and was greater in older women and in current smokers.


CONCLUSIONS
If real, the association with margarine could explain about 6% of AMI in this population of Italian women.
Tavani
A
A
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Negri
E
E
D'Avanzo
B
B
La Vecchia
C
C
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D004522:Educational Status; D005260:Female; D006801:Humans; D007558:Italy; D008383:Margarine / Q000009:adverse effects*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology*; D016017:Odds Ratio; D012307:Risk Factors; D012907:Smoking
D008383:Margarine