Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning.
Cadherins, a family of Ca2+-dependent cell-cell adhesion molecules, mediate neural cell-cell interactions and may play important roles in neural development. By searching for molecules that interact with beta-catenin, a cytoplasmic regulator of cadherins, we have identified a new member of the cadherin family, which we named human cadherin-14. Cadherin-14 had high amino acid sequence homology with the type II subgroup of cadherins and was broadly expressed in the central nervous system. Cadherin-14 is a novel neurally specific cell-cell adhesion molecule and may regulate neural morphogenesis.
Shibata
T
T
Pathology Division, National Cancer Center Research Institute, 5-1-1, Tsukiji, Tokyo 104, Japan.
Shimoyama
Y
Y
Gotoh
M
M
Hirohashi
S
S
D000595:Amino Acid Sequence; D001483:Base Sequence; D015820:Cadherins / Q000235:genetics* / Q000302:isolation & purification; D003001:Cloning, Molecular; D006801:Humans; D008969:Molecular Sequence Data; D011485:Protein Binding / Q000235:genetics; D011994:Recombinant Proteins / Q000235:genetics / Q000302:isolation & purification; D016415:Sequence Alignment
C104822:CDH18 protein, human; D015820:Cadherins; D011994:Recombinant Proteins