title: Fungicidal activity of cecropin A.
abstract: Cecropin A (CA) fungicidal properties were explored. Nongerminated and germinated Aspergillus spp. and Fusarium spp. conidia were treated with CA. CA achieved complete lethality at < or = 25 microM (99 micrograms/ml) for germinating, but not nongerminating, conidia of Aspergillus spp. CA achieved total lethality for nongerminated and germinating conidia of Fusarium spp at 1.5 microM (6 micrograms/ml). MIC and minimal lethal concentration assays in buffered RPMI medium gave similar results.
authors.affiliation: Southern Regional Research Center, U.S. Department of Agriculture, New Orleans, Louisiana 70124, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: DeLucca
authors.forename: J M
authors.initials: JM
authors.lastname: Bland
authors.forename: T J
authors.initials: TJ
authors.lastname: Jacks
authors.forename: C
authors.initials: C
authors.lastname: Grimm
authors.forename: T E
authors.initials: TE
authors.lastname: Cleveland
authors.forename: T J
authors.initials: TJ
authors.lastname: Walsh
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides; D001230:Aspergillus / Q000187:drug effects* / Q000502:physiology; D002784:Cholesterol / Q000737:chemistry; D004875:Ergosterol / Q000737:chemistry; D005670:Fusarium / Q000187:drug effects* / Q000502:physiology; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D013172:Spores, Fungal / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D023181:Antimicrobial Cationic Peptides; D010455:Peptides; C031161:cecropin A; D002784:Cholesterol; D004875:Ergosterol