title: Effect of potassium channel modulators on male sexual behavior.
abstract: In the adult sexually experienced male rat, the intracerebroventricular (i.c.v.) injection of pinacidil, a KATP channel opener, at the dose of 100-150-300 micrograms/rat worsened the copulatory performance in the presence of a receptive female, whereas the administration of glibenclamide, a KATP channel blocker, at the dose of 0.5 and 3 mg/kg intraperitoneally (i.p.) had an improving effect. These data indicate that KATP channels in target neurons may play an important role in the physiology of male sexual behavior.
authors.affiliation: Department of Biomedical Sciences, University of Modena, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Benelli
authors.forename: R
authors.initials: R
authors.lastname: Arletti
authors.forename: R
authors.initials: R
authors.lastname: Poggioli
authors.forename: E
authors.initials: E
authors.lastname: Cavazzuti
authors.forename: M
authors.initials: M
authors.lastname: Mameli
authors.forename: A
authors.initials: A
authors.lastname: Bertolini
mesh_terms: D000818:Animals; D005260:Female; D005905:Glyburide / Q000008:administration & dosage / Q000494:pharmacology*; D006146:Guanidines / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D020110:Pinacidil; D026902:Potassium Channel Blockers; D015221:Potassium Channels / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012726:Sexual Behavior, Animal / Q000187:drug effects*
chemical_list: D006146:Guanidines; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D020110:Pinacidil; D005905:Glyburide