[Biological behavior of hypopharyngeal carcinoma].
Hypopharyngeal squamous cell carcinomas (HPC) has an extremely poor prognosis. Characteristics of cell lines of head and neck squamous cell carcinomas including HPC were studied by various methods, e.g., chemosensitivity test and the immunohistochemistry staining method, to determine whether this poor prognosis is due to the biological behavior of this cancer. An HPC cell line was found to be resistant to anti tumor drugs, i.e., PEP, MTX and CPM and moderately sensitive to CDDP, 5-FU and ADM. Thermoresistance to hyperthermatic treatment and weak expression of ICAM-1 on the HPC cell line were observed. DNA synthesis by the HPC cell line was induced by stimulation with a low concentration of EGF and the amount of EGFR on these HPC cells was very high. In addition, cyclinD1 overexpression was found in the HPC cell line. Based on the above findings, further analysis of hypopharyngeal carcinoma cells and the development of a new treatment modality to control tumor growth and metastatic factors influencing the poor outcome are necessary to improve the prognosis of this cancer.
Zhou
L X
LX
Department of Otorhinolaryngology, Yokohama City University, School of Medicine.
D000970:Antineoplastic Agents / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology*; D019938:Cyclin D1; D016213:Cyclins / Q000378:metabolism; D004273:DNA, Neoplasm / Q000096:biosynthesis; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D066246:ErbB Receptors / Q000378:metabolism; D006258:Head and Neck Neoplasms / Q000473:pathology; D006801:Humans; D007013:Hypopharynx; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D015513:Oncogene Proteins / Q000378:metabolism; D010610:Pharyngeal Neoplasms / Q000737:chemistry / Q000473:pathology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D016213:Cyclins; D004273:DNA, Neoplasm; D015513:Oncogene Proteins; D018799:Intercellular Adhesion Molecule-1; D019938:Cyclin D1; D066246:ErbB Receptors