Effect of bisquaternary ammonium salts on Salmonella typhimurium.
The effect of 4,7-dioxo-3,8-dioxadekan-1, 1[bis(alkyl-dimethyldiammonium dibromides)] on growth, synthesis of macromolecules, respiration and induction of prophage in Salmonella typhimurium cells was studied. Only those compounds with alkyl chains of C10-C12 (octyl, decyl) in their molecules showed antimicrobial efficacy and inhibition incorporation of [14C]-adenine and [14C]-leucine as precursors of macromolecular biosynthesis. The highest inhibition of endogenous respiration was evoked by compounds with a long alkyl chain in the molecule (tetradecyl, hexadecyl). Endogenous respiration of the cells was more sensitive to a compound with hexadecyl than the respiration of various intermediates of the Krebs cycle. The sub-MICs of compounds with octyl induced a prophage of a lysogenic S. typhimurium strain.
Majtán
V
V
Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
Majtánová
L
L
D000225:Adenine / Q000378:metabolism; D001965:Bromides / Q000494:pharmacology*; D006842:Hydrocarbons, Brominated / Q000494:pharmacology*; D007930:Leucine / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000378:metabolism / Q000821:virology; D014775:Virus Activation / Q000187:drug effects
D001965:Bromides; D006842:Hydrocarbons, Brominated; D007930:Leucine; D000225:Adenine