Natural killer cell receptors and MHC class I interactions.
Natural killer cells express two distinct families of genes encoding receptors for polymorphic MHC class I molecules. Recent advances indicate that immunoreceptor tyrosine-based inhibitory motifs in the cytoplasmic domains of the killer cell inhibitory receptors and Ly-49 receptors recruit the SH2-containing protein tyrosine phosphatases, SHP-1 and SHP-2, resulting in inhibition of natural-killer- and T-cell-mediated cytotoxicity and cytokine secretion.
Lanier
L L
LL
DNAX Research Institute of Molecular and Cellular Biology, Department of Human Immunology, 901 California Avenue, Palo Alto, CA 94304-1104, USA. lanier@dnax.org
D000818:Animals; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D007694:Killer Cells, Natural / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000378:metabolism*
D015395:Histocompatibility Antigens Class I; D011971:Receptors, Immunologic