title: [Surgical treatment of multinodular goiter].
abstract: A homogeneous series of 361 patients operated on for multinodular goitre was analyzed. Minimum and mean follow-up were 10 and 18.6 years, respectively. In most cases a subtotal or near total thyroidectomy was performed, while total thyroidectomy was reserved for patients with cancer. The goal of the study was to verify the long term outcome of this therapeutic strategy in terms of complications, disease recurrence, need of complementary therapies (TSH-suppressive or substitutive) and reinterventions. Global recurrences were 14.7%, and 4.9% of these needed a second operation for indications similar to those of the first operation. Long term complications were vocal cord palsy 1.1% and permanent hypoparothyroidism 0.3%, while the global complications of reinterventions were 3% (n.s.). Nearly half of the patients had not followed any functional or instrumental check-up for at least 5 years nor undergone any hormonal therapy. Among the patients who had a TSH-suppressive therapy, the recurrence rate was not significantly different compared to the group that had no treatment. On the basis of these data, it seems that subtotal thyroidectomy is adequate intervention for multinodular goitre, as long as the number of clinical recurrences is not significantly high. On the contrary, it might be expected that total interventions, performed in non specialized centers, would introduce a higher rate of complications. The need for TSH-suppressive therapy to reduce recurrences was not proven.
authors.affiliation: Istituto di Clinica Chirurgica e Terapia Chirurgica, Università degli Studi di Genova.
authors.forename: F P
authors.initials: FP
authors.lastname: Mattioli
authors.forename: G C
authors.initials: GC
authors.lastname: Torre
authors.forename: G
authors.initials: G
authors.lastname: Borgonovo
authors.forename: A
authors.initials: A
authors.lastname: Arezzo
authors.forename: A
authors.initials: A
authors.lastname: Amato
authors.forename: A
authors.initials: A
authors.lastname: De Negri
authors.forename: D
authors.initials: D
authors.lastname: Bruzzone
mesh_terms: D005260:Female; D006044:Goiter, Nodular / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged