[Prediction of the central effect of pharmacological preparations in a hyperbaric environment].
A new method for predicting the central effects of pharmacological preparations in hyperbaric helio- and nitrogen-oxygen environments takes into consideration the dynamics of changes in excitability of different structures of the brain in animals compared with EEG and behavioural symptoms of the high pressure nervous syndrome (HPNS), and levels of the barometric pressure. The concept of the central effect of preparations under hyperbaric conditions should be taken into account while rendering the medicamentous assistance to aquanauts directly exposed to elevated pressure. Besides, it was shown that the strategy of searching protectors against NSHP and nitrogen narcosis may consist of selecting substances which will adequately recuperate shifts in the brain excitability due to these hyperbaric pathologies.
Sledkov
A I
AI
Institute of Evolutional Physiology and Biochemistry of IM Sechenov.
D000818:Animals; D001522:Behavior, Animal; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D002491:Central Nervous System Agents / Q000494:pharmacology*; D004558:Electric Stimulation; D004569:Electroencephalography; D004781:Environmental Exposure / Q000009:adverse effects*; D006610:High Pressure Neurological Syndrome / Q000503:physiopathology / Q000517:prevention & control*; D007222:Inert Gas Narcosis / Q000503:physiopathology / Q000517:prevention & control; D051379:Mice; D011237:Predictive Value of Tests; D011312:Pressure / Q000009:adverse effects; D011817:Rabbits
D002491:Central Nervous System Agents