UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. II. Structural elucidation.
UK-2A, B, C and D, novel antibiotics produced by Streptomyces sp. 517-02, exhibit strong antifungal activity. The structures were elucidated based on spectral and chemical evidence that these compounds are the derivatives of the nine-membered dilactone formed from serine and 4-hydroxypentanoic acid moiety.
Hanafi
M
M
Faculty of Science, Osaka City University, Japan.
Shibata
K
K
Ueki
M
M
Taniguchi
M
M
D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification; D003460:Crystallization; D006860:Hydrogen Bonding; D006868:Hydrolysis; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D008968:Molecular Conformation; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry / Q000302:isolation & purification; D013302:Streptomyces / Q000378:metabolism
D000935:Antifungal Agents; D007783:Lactones; D011725:Pyridines; C101439:UK 2A; C101494:UK 2B; C101495:UK 2C; C101496:UK 2D