Diversity and evolution of the DRB1*03 family: description of DRB1*03022,*0307,*0308.
Three previously unreported DRB1*03 alleles are described, adding to the diversity of the DRB1 family of alleles. DRB1*03022 contains a silent substitution at codon 77. DRB1*0307 differs from DRB1*03011 by a substitution at codon 26 resulting in a predicted change from tyrosine to phenylalanine. DRB1*0308 is almost identical to DRB1*03011 differing at codon 58 which specifies the glutamic acid residue commonly found in DRB1*11 alleles. The new alleles (DRB1*03022,*0307,*0308) may have arisen by gene conversion-like events and add to the increasing complexity of the HLA system.
Ellis
J M
JM
Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, District of Columbia, USA.
Steiner
N
N
Wang
J
J
Tang
T T
TT
Hurley
C K
CK
D000483:Alleles; D001483:Base Sequence; D018076:DNA, Complementary; D019143:Evolution, Molecular; D014644:Genetic Variation; D006684:HLA-DR Antigens / Q000145:classification / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008969:Molecular Sequence Data
D018076:DNA, Complementary; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains