Magnetic resonance imaging with fluid-attenuated inversion recovery pulse sequences in MELAS syndrome.
We report the brain magnetic resonance imaging findings in the case of a 5-year-old boy with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). Fluid-attenuation inversion recovery (FLAIR) imaging revealed multifocal abnormal cortical signals which were difficult to see on conventional T1- and T2-weighted images. Although the patient was in an advanced clinical stage of disease and had severe cortical atrophy, FLAIR imaging demonstrated characteristic findings of MELAS.
Kimura
M
M
Department of Pediatrics, Shimane Medical University, 89-1 Enya, Izumo, Shimane 693, Japan.
Hasegawa
Y
Y
Yasuda
K
K
Sejima
H
H
Inoue
M
M
Yamaguchi
S
S
Ando
Y
Y
Ohno
S
S
D001284:Atrophy; D001921:Brain / Q000473:pathology; D002536:Cerebral Arteries / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D017241:MELAS Syndrome / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male