Basic helix-loop-helix genes in neural development.
Several major advances in the understanding of the regulation of vertebrate neurogenesis by members of the basic helix-loop-helix (bHLH) protein family have been made in the past year. Specifically, a number of bHLH genes have been cloned and shown to convert non-neuronal fate to neuronal fate when expressed ectopically. In particular, studies on NeuroD and Neurogenin suggest a regulatory pathway, providing powerful molecular tools to study vertebrate neurogenesis.
Lee
J E
JE
Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Campus Box 347, Colorado 80309-0347, USA. jackie.lee@colorado.edu
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D004330:Drosophila; D005314:Embryonic and Fetal Development; D005796:Genes; D018257:Helix-Loop-Helix Motifs / Q000235:genetics*; D009420:Nervous System / Q000196:embryology*