Inhibition of pancreatic lipase by phenolic acids--examination in vitro.
The influence of addition 2,4,6,8, and 10 microM of benzoic and cinnamic acids and selected phenolic acids (salicylic, p-hydroxybenzoic, gentisic, protocatechuic, vanillic, syringic, o-coumaric, p-coumaric, caffeic, ferulic, sinapic) on the activity of pancreatic lipase was examined in vitro. The strongest inhibition activities were observed with caffeic, ferulic and benzoic acid, while sinapic and gentisic acids produced the lowest inhibition.
Karamać
M
M
Division of Food Science, Polish Academy of Sciences, Olsztyn, Poland.
Amarowicz
R
R
D000818:Animals; D002109:Caffeic Acids / Q000494:pharmacology; D002934:Cinnamates / Q000494:pharmacology*; D003373:Coumaric Acids / Q000494:pharmacology*; D062385:Hydroxybenzoates / Q000494:pharmacology*; D008049:Lipase / Q000037:antagonists & inhibitors*; D010179:Pancreas / Q000201:enzymology; D013329:Structure-Activity Relationship
D002109:Caffeic Acids; D002934:Cinnamates; D003373:Coumaric Acids; D062385:Hydroxybenzoates; D008049:Lipase; C040048:caffeic acid