Genetically engineered mice as animal models for NIDDM.
Genetically engineered animals carrying defined alterations in their genome can represent invaluable tools for better understanding complex polygenic diseases such as non-insulin-dependent diabetes mellitus (NIDDM) at the molecular level. The structure or expression of a number of genes potentially involved in insulin action or pancreatic beta-cell function have recently been altered in the mouse using transgenic or gene-targeting approaches. The obtention of such mice is the first step towards the development of animal models carrying multiple gene defects which would be very useful in NIDDM research.
Joshi
R L
RL
Institut Cochin de Génétique Moléculaire, INSERM U257, Paris, France.
Lamothe
B
B
Bucchini
D
D
Jami
J
J
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D004195:Disease Models, Animal; D018390:Gene Targeting; D005818:Genetic Engineering; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007515:Islets of Langerhans / Q000503:physiopathology; D051379:Mice; D008822:Mice, Transgenic
D007328:Insulin