title: Catalytic hydroxyl/amine dyads within serine proteases.
abstract: The 'catalytic triad' mechanism, which involves a serine, histidine and aspartic acid, has become synonymous with serine proteases. However, recently, mechanistically novel serine proteases have been discovered. These proteases use hydroxyl/epsilon-amine or hydroxyl/alpha-amine 'catalytic dyads' as their reactive centers.
authors.affiliation: Department of Chemistry, Ohio State University, Columbus 43210, USA.
authors.forename: M
authors.initials: M
authors.lastname: Paetzel
authors.forename: R E
authors.initials: RE
authors.lastname: Dalbey
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D006880:Hydroxy Acids / Q000737:chemistry*; D008239:Lysine / Q000737:chemistry; D012694:Serine / Q000737:chemistry; D012697:Serine Endopeptidases / Q000737:chemistry*
chemical_list: D000588:Amines; D006880:Hydroxy Acids; D012694:Serine; D012697:Serine Endopeptidases; D008239:Lysine