[The treatment of pulmonary tuberculosis patients with liver involvement].
It has been ascertained both in an experimental and clinical setting that of all the pathogenetic means of treatment pulmonary tuberculosis tocoferolum acetatum is a preparation of choice for PT patients presenting with concurrent hepatic pathology. This drug preparation has hepatoprotective immunomodulating effect. Shown for the first time is surfactant-correcting action of the drug. In a clinical setting, in a series of a total of 118 patients with pulmonary tuberculosis presenting with hepatic pathology the efficacy of tocoferolum acetatum was found to be superior to that of other hepatoprotectors. Tocoferolum acetatum eliminates the hepatotoxic reactions 2.5-3.5 times as often as hepatoprotectors and vitamins group B, ascorbic acid and bioflavonoids.
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D000276:Adjuvants, Immunologic / Q000627:therapeutic use / Q000633:toxicity; D000328:Adult; D000818:Animals; D000995:Antitubercular Agents / Q000627:therapeutic use / Q000633:toxicity; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D006168:Guinea Pigs; D006801:Humans; D008875:Middle Aged; D024505:Tocopherols; D014386:Tuberculosis, Hepatic / Q000188:drug therapy* / Q000209:etiology; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy*; D014810:Vitamin E / Q000031:analogs & derivatives / Q000627:therapeutic use / Q000633:toxicity; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D000276:Adjuvants, Immunologic; D000995:Antitubercular Agents; D014810:Vitamin E; D024502:alpha-Tocopherol; D024505:Tocopherols