[An immunomodifier--staphylococcal anatoxin--prevents the development of immunosuppression caused by informational stress in mice].
The action of information stress for 14 days leads to the development of immunosuppression, which is manifested by the suppression of humoral response to sheep red blood cells (SRBC) and the decrease of resistance to Langat virus having low pathogenicity. As shown in this investigation, an immunomodifier, purified staphylococcal toxoid (PST), protects experimental animals from the immunosuppressive effect of information stress. After the injection of PST to stress-affected mice in doses of 15 or 1.5 binding units per animal on days 9, 11 and 13 of the experiment their humoral response to SRBC and resistance to Langat virus are partially restored (by 45-60%).
Ozherelkov
S V
SV
Semenova
I B
IB
Vagin
V V
VV
Nikol'skaia
K A
KA
Savanenko
A V
AV
Semenov
B F
BF
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000833:Animals, Suckling; D000917:Antibody Formation / Q000187:drug effects; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004669:Encephalitis Viruses, Tick-Borne; D004675:Encephalitis, Tick-Borne / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D007108:Immune Tolerance / Q000187:drug effects* / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012692:Serial Passage; D013208:Staphylococcal Toxoid / Q000627:therapeutic use*; D013315:Stress, Psychological / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D013997:Time Factors
D000276:Adjuvants, Immunologic; D013208:Staphylococcal Toxoid