[Definition of a diagnostic score of malignant hyperthermia using P-31 magnetic resonance spectroscopy].
OBJECTIVE
To assess the metabolic muscular disorders associated with malignant hyperthermia (MH) using 31-P MRS, in order to develop a diagnostic tool for MH.


METHODS
Retrospective analysis of a series of case.


METHODS
Group of 39 subjects, including 13 MH susceptible (MHS), and 26 not susceptible (MHN) members of recognized MHS families, according to the results of the in vitro contracture tests.


METHODS
Each subject underwent two protocols, both including rest, exercise and recovery periods. Exercise was performed successively under aerobic and ischaemic conditions.


CONCLUSIONS
A significant early acidosis was recorded for the MHS group under both conditions of exercise (normoxia and ischaemia). However, the sensitivity of this parameter (77%) was not high enough to be considered as discriminant. Therefore a MRS score has been defined, corresponding to the sum of metabolic anomalies (acidosis, anomalies in PCr tum-over and in ATP or phosphomonoesters concentrations) recorded throughout both protocols. This score provided satisfactory results for both sensitivity (93%) and specificity (93%).


CONCLUSIONS
31-P MRS can act as a reliable diagnostic tool for MH.
Bendahan
D
D
Centre de résonance magnétique biologique et médicale (URA-CNRS 1186), faculté de médecine, Marseille, France.
Kozak-Ribbens
G
G
Confort-Gouny
S
S
Cozzone
P J
PJ
D002110:Caffeine; D003286:Contracture / Q000473:pathology; D004198:Disease Susceptibility / Q000175:diagnosis*; D006221:Halothane; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008305:Malignant Hyperthermia / Q000175:diagnosis*; D010759:Phosphorus Isotopes; D012189:Retrospective Studies
D010759:Phosphorus Isotopes; D002110:Caffeine; D006221:Halothane