title: Effects of pulsatile versus non-pulsatile pulpal pressure simulations on diffusional transport across human dentine in vitro.
abstract: The influence of a simulated pulsatile pulpal pressure on the diffusion of NaCl through slices of human dentine (n = 12) was evaluated in vitro. The average hydraulic conductance of the slices of dentine was 0.0131 +/- 0.0031 microliter/cm2 per min per cmH2O(x +/- SD). A 1 mol/l NaCl solution was placed on one side of the slices of dentine and deionized water on the other side. The time needed to reach a steady state and the quantity of NaCl that diffused through the slice were successively measured on the same slice of dentine, under three conditions: without pressure simulation, with a static pressure of 1.5 kPa, and with a pulsatile pressure varying from 1.2 to 1.8 kPa. The pressure was applied to the deionized water. When a static pressure was applied, the time required to reach a steady state increased from 24 to 30 h. When a pulsatile pressure was applied the time required to reach a steady state decreased from 24 to 12 h. No statistically significant difference was found between the quantity of NaCl that had diffused when the steady state was reached.
authors.affiliation: IMEB EA 1787, Faculté d'Odontologie, Marseille, France.
authors.forename: J
authors.initials: J
authors.lastname: Camps
authors.forename: V
authors.initials: V
authors.lastname: Santin
authors.forename: R
authors.initials: R
authors.lastname: Rieu
authors.forename: J
authors.initials: J
authors.lastname: Fuseri
authors.forename: J C
authors.initials: JC
authors.lastname: Franquin
mesh_terms: D000704:Analysis of Variance; D003782:Dental Pulp / Q000502:physiology; D003806:Dentin Permeability / Q000502:physiology*; D019234:Dentinal Fluid / Q000502:physiology; D004058:Diffusion; D006801:Humans; D006874:Hydrostatic Pressure; D011673:Pulsatile Flow; D012965:Sodium Chloride / Q000378:metabolism
chemical_list: D012965:Sodium Chloride