[Local cerebral ischemia in rats induced by ligation of the middle cerebral artery].
A model of local cerebral ischemia induced by ligation of the middle cerebral artery, which is a modification of the techniques proposed by A. Tamura and others, is suggested. It allows experiments to be conducted on conscious animals with appraisal of the morpho-functional state of the nervous system. Ligation of the middle cerebral artery caused a marked decrease (by 85 +/- 9%) in the blood flow in the temporal area of the cerebral cortex. The use of this method will promote a purposeful search for drugs for the treatment of patients with ischemic disorders of cerebral circulation.
Topchian
A V
AV
Mirzoian
R S
RS
Balasanian
M G
MG
D000818:Animals; D002545:Brain Ischemia / Q000209:etiology* / Q000503:physiopathology; D002536:Cerebral Arteries / Q000601:surgery*; D004195:Disease Models, Animal; D017078:Laser-Doppler Flowmetry; D008026:Ligation; D008833:Microcirculation; D008866:Microsurgery / Q000295:instrumentation / Q000379:methods; D010296:Parietal Lobe / Q000098:blood supply; D051381:Rats; D017208:Rats, Wistar