Antibodies to the HIV-1 p17 protein cross-react with human superoxide dismutase-2.
Antibodies reacting with the gag protein p17 of the human immunodeficiency virus type 1 (HIV-1) can occasionally be found in the serum of non-HIV-1-infected individuals. Conversely, anti-p17 antibodies can also react with human tissues from non-infected individuals. Here we report on the isolation from human liver of a molecule that is immunoreactive with anti-p17 antibodies. This molecule was purified to homogeneity and identified as superoxide dismutase-2 (manganese type SOD). Both human SOD-2 and HIV-1 p17 contain the LQPALK hexapeptide which may serve as a common antigenic determinant. This study indicates that human SOD-2 is a target for anti-p17 antibodies and suggests that HIV-1-negative individuals may possess SOD-2 auto-antibodies that cross-react with HIV-1 p17.
Kato
T
T
Third Department of Internal Medicine, Yamagata University School of Medicine, Japan.
Suzuki
J
J
Daimon
M
M
Sasaki
H
H
Ishikawa
K
K
D000595:Amino Acid Sequence; D000911:Antibodies, Monoclonal; D001921:Brain / Q000201:enzymology; D003429:Cross Reactions; D015683:Gene Products, gag / Q000737:chemistry / Q000276:immunology*; D015483:HIV Antibodies; D015488:HIV Antigens / Q000737:chemistry / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D007668:Kidney / Q000201:enzymology; D008969:Molecular Sequence Data; D018482:Muscle, Skeletal / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D010446:Peptide Fragments / Q000737:chemistry* / Q000276:immunology; D017386:Sequence Homology, Amino Acid; D013482:Superoxide Dismutase / Q000737:chemistry / Q000276:immunology*; D014764:Viral Proteins; D054301:gag Gene Products, Human Immunodeficiency Virus
D000911:Antibodies, Monoclonal; D015683:Gene Products, gag; D015483:HIV Antibodies; D015488:HIV Antigens; D010446:Peptide Fragments; D014764:Viral Proteins; D054301:gag Gene Products, Human Immunodeficiency Virus; C054858:p17 protein, Human Immunodeficiency Virus Type 1; D013482:Superoxide Dismutase