[The participation of the serotonin link in the neurochemical mechanism of transcranial electroanalgesia].
Metergoline and 5, 7-dihydroxytryptamine were found to suppress and to prevent an electroanalgesic effect, resp. An increase in the serotonine contents in the CSF after electroanalgesia suggests an activation of the brain serotoninergic system. DL-5-hydroxytryptophan and allopurinol enhanced the electroanalgetic effect. The data obtained suggests an existence of a serotoninergic component of the transcranial electroanalgesia mechanism.
Lebedev
V P
VP
Savchenko
A B
AB
Otellin
V A
VA
Kucherenko
R P
RP
D000818:Animals; D004558:Electric Stimulation; D008297:Male; D010146:Pain / Q000209:etiology / Q000503:physiopathology; D059408:Pain Management; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000134:cerebrospinal fluid / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013997:Time Factors; D004561:Transcutaneous Electric Nerve Stimulation
D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D012701:Serotonin