[The potentials for therapy of the postresuscitation process using regulatory peptides after 10 and 15 minutes of heart arrest].
The therapeutic effect of a single systemic injection of regulatory peptides was assessed in experiments oil white rats exposed to 10- and 15-min heart arrest. The effect of regulatory peptides was found to depend on the initial body resistance to hypoxia and on the duration of heart arrest. Positive effects of thyrotropin-releasing factor, ACTH4-10 and substance P on the recovery of cerebral function grew weaker as the duration of heart arrest increased, whereas the effects of oxitocin and somatostatin were unchanged, and that of taftsin even increased. In animals nonresistant to hypoxia cardiopulmonary resuscitation and survival of 50% of animals after 15-min heart arrest was provided by injection of thyrotropin-releasing factor at the beginning of resuscitation and of somatostatin 30 min later.
Volkov
A V
AV
Murav'ev
O V
OV
Misharina
G V
GV
D000818:Animals; D004353:Drug Evaluation, Preclinical; D005260:Female; D006323:Heart Arrest / Q000503:physiopathology / Q000628:therapy*; D000860:Hypoxia / Q000503:physiopathology / Q000628:therapy; D008297:Male; D010455:Peptides / Q000627:therapeutic use*; D051381:Rats; D012151:Resuscitation / Q000009:adverse effects*; D013997:Time Factors
D010455:Peptides