[Cerebral proton spectroscopy of people infected with the human immunodeficiency virus].
BACKGROUND
This article presents a combined magnetic resonance imaging and proton spectroscopy protocol (MRI/1H-MRS) applied to study the brain of human immunodeficiency virus (HIV) infected patients. The spectroscopic results were compared with clinical and radiological parameters.


METHODS
The proton spectra of 57 HIV patients and 20 control subjects were obtained from a volume of interest of 8 cm3 located in the parietooccipital region of the brain that did not include any focal lesion. The resonance areas due to N-acetyl aspartate (NAA), creatine (Cr) and choline (Cho) were obtained. The MRI exam allowed us to determine the presence of focal or diffuse lesions and the degree of atrophy. Finally, the clinical exploration included the performance of a Mini-Mental test. The NAA/Cr, NAA/Cho and Cho/Cr ratios were correlated with clinical characteristics, the result of the Mini-Mental test, the presence of lesions and the degree of atrophy.


RESULTS
There were altered spectral patterns in a volume of the brain that did not contain any focal lesion. The decrease in the NAA/Cr or NAA/Cho ratios was significative when considering the presence of atrophy, the existence of signs of cognitive deficiencies or the diagnosis of AIDS-dementia complex.


CONCLUSIONS
The spectral changes found in the present study suggest the existence of neuronal lesions that would be due to the HIV-infection. A combined MRI/1H-MRS study may provide a more complete information about the neurological impairment by HIV and could constitute a marker of AIDS-dementia complex.
Alonso
J
J
Unitat de Ressonància Magnètica Vall d'Hebron, Institut de Diagnòstic per la lmatge, Barcelona.
Rovira
A
A
Capellades
J
J
Ocaña
I
I
Río
J
J
Wicklow
K
K
Sauter
R
R
Gili
J
J
D000328:Adult; D001927:Brain Diseases / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013052:Spectrometry, X-Ray Emission