The cytotoxic T-lymphocyte response to Sendai virus is unimpaired in the absence of gamma interferon.
Sendai virus is eliminated from the respiratory tract of gamma interferon (IFN-gamma) -/- BALB/c mice with normal kinetics. The level of virus-specific cytotoxic T-lymphocyte (CTL) activity in the cell population recovered by bronchoalveolar lavage is unimpaired, the prevalence of interleukin-4 (IL-4)-producing cells is increased, and the titers of virus-specific immunoglobulins IgG1 and IgG2b are higher in the IFN-gamma -/- mice. The emergence of this T-helper 2 response profile in both lymphoid tissue and the pneumonic lung has no obvious deleterious consequences. Virus clearance is slightly delayed following depletion of the CD4+ subset, with the effect being similar in magnitude for IFN-gamma -/- and +/+ mice. However, the generation of CTL precursors (CTLp) is diminished in the IFN-gamma -/- (but not +/+) mice in the absence of concurrent CD4+ T help. Apparently the clonal expansion of the CTLp population can be promoted either by a cytokine (perhaps IL-2) produced by the IFN-gamma -/- CD4+ T cells or by IFN-gamma made by other cell types in the +/+ mice.
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Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Tripp
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Sangster
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Doherty
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D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007371:Interferon-gamma / Q000235:genetics / Q000276:immunology*; D015847:Interleukin-4 / Q000032:analysis; D015848:Interleukin-5 / Q000032:analysis; D051379:Mice; D008807:Mice, Inbred BALB C; D011024:Pneumonia, Viral / Q000097:blood / Q000276:immunology* / Q000821:virology; D018108:Respirovirus / Q000276:immunology* / Q000302:isolation & purification; D010253:Respirovirus Infections / Q000097:blood / Q000276:immunology* / Q000821:virology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D015848:Interleukin-5; D015847:Interleukin-4; D007371:Interferon-gamma