title: Maternal serum alpha-fetoprotein and epithelial tumour marker concentrations are not increased by fetal sacrococcygeal teratoma.
abstract: Maternal serum alpha-fetoprotein (AFP) and total beta-human chorionic gonadotrophin (hCG) concentrations were measured at the 15th gestational week in ten pregnancies complicated by fetal sacrococcygeal teratoma. The findings corresponded to those in normal pregnancies. Similarly, third-trimester concentrations of cancer antigen 12-5, tumour-associated trypsin inhibitor, and the amino-terminal propeptide of type III procollagen in the maternal serum were not significantly elevated. Histologically mature and immature/malignant cases did not differ from each other as regards the above-mentioned parameters. This abnormality cannot be detected by maternal serum trisomy screening in the second trimester.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Kuopio, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Kirkinen
authors.forename: S
authors.initials: S
authors.lastname: Heinonen
authors.forename: K
authors.initials: K
authors.lastname: Vanamo
authors.forename: M
authors.initials: M
authors.lastname: Ryynänen
mesh_terms: D015415:Biomarkers / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D005260:Female; D005315:Fetal Diseases / Q000097:blood*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010446:Peptide Fragments / Q000097:blood; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011296:Prenatal Diagnosis / Q000379:methods*; D011347:Procollagen / Q000097:blood; D011446:Prospective Studies; D011863:Radioimmunoassay; D012445:Sacrococcygeal Region; D013724:Teratoma / Q000097:blood*; D014314:Trisomy / Q000175:diagnosis; D014359:Trypsin Inhibitor, Kazal Pancreatic / Q000097:blood; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D015415:Biomarkers; D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; D011347:Procollagen; D000509:alpha-Fetoproteins; C041876:procollagen Type III-N-terminal peptide; D014359:Trypsin Inhibitor, Kazal Pancreatic