title: Sotalol-induced torsades de pointes in patients with renal failure.
abstract: The risk of torsades de pointes in patients on sotalol is increased in the setting of renal failure. QT dispersion and prolonged QT intervals have been described as markers for pro-arrhythmia. Four cases of torsades de pointes caused by low dose sotalol in patients with renal failure are reported. All four cases demonstrated that the 12-lead electrocardiogram, with markedly prolonged QT intervals and increased QT dispersion, could have been used to predict pro-arrhythmia.
authors.affiliation: Sunnybrook Health Science Centre, Toronto, Ontario.
authors.forename: D
authors.initials: D
authors.lastname: Dancey
authors.forename: Z
authors.initials: Z
authors.lastname: Wulffhart
authors.forename: P
authors.initials: P
authors.lastname: McEwan
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000009:adverse effects*; D000368:Aged; D000369:Aged, 80 and over; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000150:complications* / Q000628:therapy; D012307:Risk Factors; D013015:Sotalol / Q000009:adverse effects*; D016171:Torsades de Pointes / Q000139:chemically induced*
chemical_list: D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D013015:Sotalol