[Lipoprotein anomalies in HIV infections].
Alterations in lipid parameters occur during many acute infections. Different studies suggest that variations in lipid parameters can be used as markers of the progression of human immunodeficiency virus (HIV) infection. Hypocholesterolemia is observed in asymptomatic HIV+ subjects, then hypertriglyceridemia appears in patients with AIDS. Several hypotheses have been raised concerning the potential causes and consequences of these modifications. Cytokine effects on different enzymes of lipid metabolism, studied in vitro and in vivo, are thought to be partially responsible for the dyslipidemia. Hypertriglyceridemia could participate in cachexia and dementia could be facilitated by the changes in cholesterol metabolism. The use of the lipid parameters is proposed in HIV positive subjects, especially during anti-viral treatment.
Keréveur
A
A
Laboratoire de Biochimie, Hôpital Broussais, Paris.
Cambillau
M
M
Kazatchkine
M
M
Moatti
N
N
D002784:Cholesterol / Q000097:blood*; D015658:HIV Infections / Q000097:blood* / Q000150:complications / Q000628:therapy; D006801:Humans; D015228:Hypertriglyceridemia / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D008074:Lipoproteins / Q000097:blood; D013997:Time Factors
D008074:Lipoproteins; D002784:Cholesterol