A reductive acidolysis final deprotection strategy in solid phase peptide synthesis based on safety-catch protection.
A reductive acidolysis final deprotection strategy in solid phase peptide synthesis was developed using a new safety-catch type of semi-permanent protecting groups and new linkers which were derived from 4-methylsulfinylbenzyl protection. This new strategy was based on a two-dimensional protection scheme employing acid-labile temporary and acid-stable but reductive acidolysis-cleavable semi-permanent protecting groups. By using this strategy, we successfully synthesized four model peptides, of which two contained C-terminal amide.
Kimura
T
T
Department of Medicinal Chemistry, Kyoto Pharmaceutical University, Japan.
Fukui
T
T
Tanaka
S
S
Akaji
K
K
Kiso
Y
Y
D000595:Amino Acid Sequence; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry
D010455:Peptides