Heterocyclic analogues of quinone methide: preparation and cytotoxicity of 3-oxo-3H-pyrazolo[1,5-a]indole derivatives.
A series of 3-oxo-3H-pyrazolo[1,5-a]indole derivatives was prepared and characterized as heterocyclic analogues of quinone methide. These compounds showed some cytotoxicity to cancer cells, but were ineffective in an in vivo test against murine leukemia L1210.
Katayama
H
H
Niigata College of Pharmacy, Japan.
Tagawa
N
N
Kawada
Y
Y
Shiobara
K
K
Kaneko
K
K
Honda
Y
Y
Kondo
N
N
Ikeda
Y
Y
D000818:Animals; D004354:Drug Screening Assays, Antitumor; D045563:Indolequinones; D007211:Indoles / Q000138:chemical synthesis*; D007939:Leukemia L1210 / Q000188:drug therapy; D008297:Male; D051379:Mice; D016685:Mitomycin / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D011809:Quinones / Q000138:chemical synthesis*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D045563:Indolequinones; D007211:Indoles; D011720:Pyrazoles; D011809:Quinones; C068040:quinone methide; D016685:Mitomycin