[The effect of transitional metal cations on pepsinogen extrusion by dispersed gastric glands].
It has been found that transient metal cations (Mn2+, Co2+, Cd2+, La3+) cause substantial disturbance of pepsinogen extrusion by isolated gastric glands of guinea pigs. In low concentrations (10(-5)-10(-4) mol/l) they are found to decrease spontaneous and stimulated pepsinogen extrusion by inhibition of Ca2+ influx into the secretory cells. In high concentrations (10(-3)-10(-2) mol/l) metal cations are able either to stimulate (Mn2+, Co2+) or to inhibit (La3+, Cd2+) pepsinogen extrusion depending on their type. Their effect is not connected with disturbance of calcium transport into the cells.
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D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008670:Metals / Q000494:pharmacology*; D010435:Pepsinogens / Q000187:drug effects* / Q000378:metabolism*; D013997:Time Factors
D008670:Metals; D010435:Pepsinogens; D002118:Calcium