title: Acute and chronic human adenovirus pneumonia: cellular and extracellular matrix components.
abstract: We present a comparative histopathological study of both acute and chronic human adenovirus pneumonia, with reference to the cellular and extracellular matrix components. Seventeen lungs from autopsied patients whose ages ranged from 2 to 60 months were studied. Adenovirus types 1, 2, 3, 5, and 7 were isolated from 15 patients with acute lung disease, and types 2 and 7 were isolated from the other two patients with chronic pulmonary illness. The results indicated the occurrence of two basic patterns of adenovirus interstitial pneumonia (1) classic pattern (acute), characterized by necrosis and degeneration and many type II pneumocytes with intranuclear inclusion bodies, which were positive for adenovirus DNA by in situ hybridization, and (2) proliferative or proliferative-productive pattern (chronic), which presented with diffuse pulmonary fibrosis and the interstitial proliferation of fibroblast-like cells, compatible with myofibroblasts (positive for vimentin and alpha smooth muscle actin), and increase in collagen types I and III, elastic fibers, and proteoglycans. Alveolar collapse appears to be an important pathogenetic mechanism in the development of this pattern.
authors.affiliation: Departamento de Patologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil.
authors.forename: F C
authors.initials: FC
authors.lastname: Rosman
authors.forename: A S
authors.initials: AS
authors.lastname: Mistchenko
authors.forename: H S
authors.initials: HS
authors.lastname: Ladenheim
authors.forename: J P
authors.initials: JP
authors.lastname: do Nascimento
authors.forename: H N
authors.initials: HN
authors.lastname: Outani
authors.forename: K
authors.initials: K
authors.lastname: Madi
authors.forename: H L
authors.initials: HL
authors.lastname: Lenzi
mesh_terms: D000208:Acute Disease; D000256:Adenoviridae / Q000472:pathogenicity*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003593:Cytoplasm / Q000737:chemistry*; D016326:Extracellular Matrix Proteins / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011024:Pneumonia, Viral / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
chemical_list: D016326:Extracellular Matrix Proteins