title: [Thrombolytic therapy with rt-PA of recurrent thrombosis in tricuspid valve prosthesis during pregnancy].
abstract: The authors report a case of a woman who had two episodes of a tricuspid Saint-Jude prosthesis thrombosis treated with fibrinolysis using rt-PA, during the fourth month of pregnancy. A first course of thrombolytic therapy was successful with normal valve function despite threatening abortion and uterine bleeding. An early rethrombosis of the prosthetic valve and a failure of a second course of thrombolysis required the interruption of pregnancy with a replacement of the tricuspid valve prosthesis.
authors.affiliation: Service de réanimation polyvalente, hôpital Edouard-Herriot, Lyon, France.
authors.forename: C
authors.initials: C
authors.lastname: Di Roio
authors.forename: D
authors.initials: D
authors.lastname: Perrot
authors.forename: J M
authors.initials: JM
authors.lastname: Védrinne
authors.forename: G
authors.initials: G
authors.lastname: Méllier
authors.forename: J
authors.initials: J
authors.lastname: Robin
authors.forename: J
authors.initials: J
authors.lastname: Motin
mesh_terms: D000032:Abortion, Therapeutic; D000328:Adult; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008796:Metrorrhagia / Q000209:etiology; D010960:Plasminogen Activators / Q000627:therapeutic use*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D012008:Recurrence; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D014261:Tricuspid Valve
chemical_list: D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator