title: [Presence of markers predictive of type I pre-diabetes mellitus status in relatives of patients with type I diabetes mellitus].
abstract: BACKGROUND
  The aim of this study was to analyze the predictive factors of IDDM in first degree relatives of IDDM patients.
  
  
  METHODS
  From 1992 to 1994, 1,053 first degree relatives were screened for measuring islet cell antibodies (ICA) by indirect immunofluorescence (iFl). In all ICA positive subjects, beta cell function was analyzed by intravenous glucose tolerance test (IVGTT) and other immunologic parameters were also studied: anti-insulin antibodies (IAA) by radiobinding and antibodies to glutamic acid decarboxylase (GADAb) by ELISA methods.
  
  
  RESULTS
  ICA were found in 3.1% of the first degree relatives. IVGTT showed a significant decrease in acute first phase of insulin response to glucose (IRI 1 minute + 3 minute) in those with ICA > or = 20 JDF units. In patients with ICA > or = 20 JDF units, 20% were found to be positive for IAA and 40% were positive for GAdAb. Thirty-one percent (10/32) of ICA positive first degree relatives fulfilled prediabetes criteria. During follow-up, 40% (4/10) of these prediabetic patients developed IDDM.
  
  
  CONCLUSIONS
  This study confirms the possibility of identifying among first degree relatives of IDDM patients the subgroup with high risk of developing IDDM thus allowing the initiation of therapy for preventing or delaying IDDM onset.
authors.affiliation: Servicio de Endocrinología, Hospital Clínic i Provincial de Barcelona.
authors.forename: C
authors.initials: C
authors.lastname: Rodríguez-Villar
authors.forename: I
authors.initials: I
authors.lastname: Conget
authors.forename: E
authors.initials: E
authors.lastname: Esmatjes
authors.forename: I
authors.initials: I
authors.lastname: Levy
authors.forename: J
authors.initials: J
authors.lastname: Calvet
authors.forename: D
authors.initials: D
authors.lastname: Figuerola
authors.forename: M
authors.initials: M
authors.lastname: Bergua
authors.forename: A
authors.initials: A
authors.lastname: Gutiérrez
authors.forename: J
authors.initials: J
authors.lastname: Miralles
authors.forename: M
authors.initials: M
authors.lastname: Millán
authors.forename: M
authors.initials: M
authors.lastname: Peig
authors.forename: R
authors.initials: R
authors.lastname: Gomis
mesh_terms: D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000097:blood; D015415:Biomarkers; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000235:genetics* / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000097:blood / Q000235:genetics* / Q000276:immunology; D011237:Predictive Value of Tests; D012307:Risk Factors
chemical_list: D000906:Antibodies; D015415:Biomarkers