title: The presence of Helicobacter pylori in nonoperated duodenal ulcer patients compared to patients late after highly selective vagotomy.
abstract: There are many recent studies that clearly suggest that Helicobacter pylori (HP) is an etiological agent for duodenal ulcer disease (1-3). Randomized trials have shown that duodenal ulcers treated by omeprazole or H2 blockers heal faster if HP is eradicated concurrently (4-6). Besides, several studies have demonstrated that eradication of HP significantly reduces duodenal ulcer relapses (7-9). Patients followed up to 7 years after eradication of HP demonstrated that 92% remained HP negative, with only 3% recurrence (10). Highly selective vagotomy has been the treatment of choice for duodenal ulcer patients who are candidates for surgical therapy (11, 12). The late results have shown an approximately 10% recurrence rate 8 to 10 years after surgery (13, 14). We hypothesized that in these asymptomatic cases after HSV, HP probably will exist in a minor proportion of cases, similar to what happens after successful medical antiulcer therapy. Therefore the purpose of the present study was to determine the HP status at the antrum in a group of nonoperated duodenal ulcer patients compared to a group submitted to highly selective vagotomy many years prior to the actual study.
authors.affiliation: Gastrointestinal Unit, Department of Surgery University Hospital, Santiago, Chile.
authors.forename: A
authors.initials: A
authors.lastname: Csendes
authors.forename: G
authors.initials: G
authors.lastname: Smok
authors.forename: M
authors.initials: M
authors.lastname: Coronel
authors.forename: R
authors.initials: R
authors.lastname: Avendaño
authors.forename: G
authors.initials: G
authors.lastname: Zenteno
authors.forename: H
authors.initials: H
authors.lastname: Cordova
mesh_terms: D000328:Adult; D000368:Aged; D004381:Duodenal Ulcer / Q000382:microbiology*; D005260:Female; D005500:Follow-Up Studies; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011706:Pyloric Antrum / Q000382:microbiology*; D012008:Recurrence; D014628:Vagotomy