title: The relationship between maternal birthweight and gestational age in twins and singletons and those of their offspring in Norway.
abstract: In order to elucidate whether maternal plurality affects offspring intrauterine growth, the relationship between birthweight and gestational age of twins and singletons and those of their first singleton liveborn children in Norway was studied using data from the Medical Birth Registry. The population-based sample consisted of 49,698 mother-offspring pairs (48,842 with singleton and 856 with twin-mothers). In bivariate analyses, no significant differences in mean birthweight and gestational age of offspring of twin and singleton mothers were found, although the mean birthweight and gestational age of the twin-mothers themselves were significantly lower than those of singletons (819 g and 14 days respectively). In multiple regression analysis, the expected birthweight of offspring was 230.3 g (95% CI: 193.2-267.4 g) higher when the mother was a twin than when the mother was a singleton, when controlling for non-standardised maternal birthweight. When adjusting for relative maternal birthweight (z-score), the association between maternal plurality and offspring birthweight was not statistically significant. The results suggest that being born as a twin has no substantial consequences on offspring growth in utero and show that mean differences in birthweight between twins and singletons should be standardised when both groups are included in multivariate studies.
authors.affiliation: Department of Epidemiology, National Institute of Public Health, Oslo, Norway.
authors.forename: S V
authors.initials: SV
authors.lastname: Glinianaia
authors.forename: P
authors.initials: P
authors.lastname: Magnus
authors.forename: R
authors.initials: R
authors.lastname: Skjaerven
authors.forename: L S
authors.initials: LS
authors.lastname: Bakketeig
mesh_terms: D001724:Birth Weight / Q000502:physiology*; D005314:Embryonic and Fetal Development / Q000502:physiology*; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D015999:Multivariate Analysis; D009664:Norway / Q000453:epidemiology; D012044:Regression Analysis; D014427:Twins