Double cancer of the stomach, one AFP-producing tumor.
In recent years, many cases of alpha-fetoprotein-producing gastric cancer (AFPGC) characterized by increased serum levels of alpha-fetoprotein (AFP) and AFP positivity of the gastric cancer have been reported. Here we present a case of AFPGC coexistent with a different histological type of gastric cancer: The AFPGC was Borrmann type 1 advanced gastric cancer with multiple liver metastasis and appeared to produce both AFP and des-gamma-carboxy prothrombin (PIVKA-II). The second cancer was IIc type early gastric cancer and did not produce AFP. Despite receiving palliative chemotherapy, the patient died, due to hepatic failure, 45 days after admission.
Hyodo
T
T
Department of Internal Medicine, Nomura Hospital, Ehime, Japan.
Kawamoto
R
R
D000230:Adenocarcinoma / Q000737:chemistry / Q000556:secondary*; D015415:Biomarkers; D014408:Biomarkers, Tumor; D001706:Biopsy; D017809:Fatal Outcome; D005773:Gastroscopy; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000737:chemistry / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000737:chemistry / Q000473:pathology*; D011498:Protein Precursors / Q000032:analysis; D011516:Prothrombin / Q000032:analysis; D013274:Stomach Neoplasms / Q000737:chemistry / Q000473:pathology*; D000509:alpha-Fetoproteins / Q000032:analysis*
D015415:Biomarkers; D014408:Biomarkers, Tumor; D011498:Protein Precursors; D000509:alpha-Fetoproteins; C008208:acarboxyprothrombin; D011516:Prothrombin