title: Regional cerebral blood flow and negative/positive symptoms in 24 drug-naive schizophrenics.
abstract: SPECT/PET studies in schizophrenia revealed inconsistent changes of regional cerebral blood flow (rCBF). Frontal hyperperfusion as well as hypoperfusion are described. This study was undertaken to investigate the relations between rCBF, psychopathology according to PANSS and effects of neuroleptic therapy.
  
  
  METHODS
  Twenty-four drug-naive acute patients with a first manifestation of schizophrenia were examined with 99mTc-HMPAO brain SPECT and assessed according to PANSS. Of these, 22 were controlled again after neuroleptic treatment. Following attenuation correction, region-to-cerebellar count ratios were obtained from 98 irregular regions of interest drawn in all slices (6.25 mm). The ratios were compared to 20 control subjects, and changes lying outside of 2 s.d. were considered abnormal.
  
  
  RESULTS
  In different drug-naive patients, hyperperfusion as well as hypoperfused patterns were found. In drug-naive patients, the seven subscores of positive symptoms (pos 1-7) in PANSS showed different correlations to rCBF: Formal thought disorders (pos 2) and grandiosity (pos 5) were positively correlated to bifrontal and bitemporal rCBF (r = +0.59 to +0.70). Delusional ideas (pos 1), hallucinatory behavior (pos 3) and suspiciousness (pos 6) demonstrated a negative correlation to bifrontal, cingulate, left temporal and left thalamic rCBF (r = -0.59 to -0.66). Stereotyped ideas (neg 7) as a negative symptom showed a negative correlation to left frontal, left temporal and left parietal rCBF (r = -0.59 to -0.65). No correlations were found between residual positive symptoms and rCBF after neuroleptic treatment and clinical improvement, but all negative symptoms (neg 1-7) had a negative correlation to bifrontal, bitemporal, cingulate, basal ganglia and thalamic rCBF (r = -0.59 to -0.74).
  
  
  CONCLUSIONS
  Our results illustrate that different positive symptoms are accompanied by different rCBF values: some induce hyperperfusion, others hypoperfusion. After therapy (and reduction of positive symptoms), only negative symptoms correlate exclusively to hypoperfusion. This may be the crucial factor in explaining inconsistencies of past results in perfusion pattern in drug-naive schizophrenic patients.
authors.affiliation: Department of Nuclear Medicine, Technical University of Aachen, Germany.
authors.forename: O
authors.initials: O
authors.lastname: Sabri
authors.forename: R
authors.initials: R
authors.lastname: Erkwoh
authors.forename: M
authors.initials: M
authors.lastname: Schreckenberger
authors.forename: U
authors.initials: U
authors.lastname: Cremerius
authors.forename: G
authors.initials: G
authors.lastname: Schulz
authors.forename: C
authors.initials: C
authors.lastname: Dickmann
authors.forename: H J
authors.initials: HJ
authors.lastname: Kaiser
authors.forename: E M
authors.initials: EM
authors.lastname: Steinmeyer
authors.forename: H
authors.initials: H
authors.lastname: Sass
authors.forename: U
authors.initials: U
authors.lastname: Buell
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D015588:Observer Variation; D015609:Organotechnetium Compounds; D010091:Oximes; D012039:Regional Blood Flow / Q000187:drug effects; D012559:Schizophrenia / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000503:physiopathology; D012720:Severity of Illness Index; D013223:Statistics as Topic; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D014150:Antipsychotic Agents; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime