title: Long-term effects of water-soluble dietary fiber in the management of hypercholesterolemia in healthy men and women.
abstract: Fifty-one healthy, moderately hypercholesterolemic men and women consuming their usual fat-modified diets completed a 6-month, randomized, double-blind, placebo-controlled, parallel comparison of 15 g/day supplemental water-soluble dietary fiber (WSDF; a mixture of psyllium, pectin, guar gum, and locust bean gum) and an inactive WSDF control (acacia gum). Compliance with the treatments was > 95%, adverse effects were minimal, and body weights remained constant. The WSDF mixture yielded 6.4% and 10.5% reductions in mean plasma total and low-density lipoprotein cholesterol concentrations, respectively, after 8 weeks, which were sustained at 16 and 24 weeks. Mean plasma high-density lipoprotein cholesterol and triglyceride concentrations were unchanged. No significant changes in mean plasma lipid or lipoprotein concentrations were observed in the control group. These data demonstrate that a WSDF approach to cholesterol management is effective as an adjunct to a fat-modified diet in healthy, moderately hypercholesterolemic men and women.
authors.affiliation: Department of Health Sciences, Shaklee Corporation (a division of Yamanouchi Pharmaceutical Co., Ltd.), San Francisco, California 94111, USA.
authors.forename: C D
authors.initials: CD
authors.lastname: Jensen
authors.forename: W
authors.initials: W
authors.lastname: Haskell
authors.forename: J H
authors.initials: JH
authors.lastname: Whittam
mesh_terms: D000328:Adult; D004043:Dietary Fiber / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000178:diet therapy*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D004043:Dietary Fiber; D008074:Lipoproteins