title: Increased levels of interleukin-1beta and soluble intercellular adhesion molecule-1 in cerebrospinal fluid of patients with subacute sclerosing panencephalitis.
abstract: Proinflammatory cytokines (interleukin [IL]-1beta, tumor necrosis factor [TNF]-alpha, and IL-6) and soluble intercellular adhesion molecule-1 (sICAM-1) were measured in paired cerebrospinal fluid (CSF) and serum samples from patients with subacute sclerosing panencephalitis (SSPE), multiple sclerosis (MS), or other neurologic diseases (OND) by ELISA. IL-1beta was significantly increased in CSF of the SSPE group compared with levels in the MS or OND group. IL-1beta CSF/serum ratios were higher in the SSPE than in the MS or OND group. TNF-alpha and IL-6 levels were similar in the 3 groups. CSF sICAM-1 was higher in the SSPE group than in the MS or OND group. sICAM-1 CSF/serum ratios were higher in the SSPE than the OND group. The increased CSF/serum ratios of IL-1beta and sICAM-1 in SSPE indicate synthesis of IL-1beta and sICAM-1 in the central nervous system and may be important in the pathogenesis of disease.
authors.affiliation: Institute for Basic Research in Developmental Disabilities, Staten Island, and State University of New York at Stony Brook, 10314-6399, USA.
authors.forename: P D
authors.initials: PD
authors.lastname: Mehta
authors.forename: J
authors.initials: J
authors.lastname: Kulczycki
authors.forename: S P
authors.initials: SP
authors.lastname: Mehta
authors.forename: P K
authors.initials: PK
authors.lastname: Coyle
authors.forename: H M
authors.initials: HM
authors.lastname: Wisniewski
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000134:cerebrospinal fluid*; D007375:Interleukin-1 / Q000134:cerebrospinal fluid*; D015850:Interleukin-6 / Q000134:cerebrospinal fluid; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid; D013344:Subacute Sclerosing Panencephalitis / Q000134:cerebrospinal fluid*; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1