Immunisation of sheep by drug-abbreviated infections of Ostertagia circumcincta and Trichostrongylus colubriformis against field challenge of gastro-intestinal nematodes.
A very high level of protection was achieved against homologous (up to 97%) and heterologous (up to 87%) infections in 12-month-old Romney sheep immunised with oxfendazole-abbreviated infections of Ostertagia circumcincta and Trichostrongylus colubriformis. No significant protection occurred following ivermectin-abbreviated infections. None of the immunised sheep showed an increase in antibody level against excretory-secretory antigen of T. colubriformis infective larvae. The immunisation procedures did not cause a decrease in wool production, or liveweight gains compared with non-immunised controls.
Stankiewicz
M
M
AgResearch Wallaceville Animal Research Centre, Upper Hutt, New Zealand. stankiewiczm@agresearch.cri.nz
Cabaj
W
W
Pernthaner
A
A
Hadas
E
E
D000821:Animal Feed; D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D000947:Antigens, Helminth / Q000276:immunology; D000969:Antinematodal Agents / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use; D005260:Female; D005767:Gastrointestinal Diseases / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D007559:Ivermectin / Q000627:therapeutic use; D010028:Ostertagia / Q000276:immunology* / Q000302:isolation & purification; D010029:Ostertagiasis / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D010058:Oviposition; D010270:Parasite Egg Count; D006109:Poaceae; D012756:Sheep; D012757:Sheep Diseases; D014253:Trichostrongylosis / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D014254:Trichostrongylus / Q000276:immunology* / Q000302:isolation & purification; D014612:Vaccines
D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D000969:Antinematodal Agents; D001562:Benzimidazoles; D014612:Vaccines; D007559:Ivermectin; C011030:oxfendazole