Immunodiagnosis of prion disease.
The immunodiagnosis of prion diseases is of critical importance due to the transmissibility of these conditions and their fatal prognosis. A panel of monoclonal and polyclonal antibodies have been generated for use in the study and diagnosis of these diseases. This manuscript describes the generation and characterization of these antibodies as well as their diagnostic application.
Kascsak
R J
RJ
NYS Institute for Basic Research In Developmental Disabilities, Staten Island, New York 10314, USA.
Fersko
R
R
Pulgiano
D
D
Rubenstein
R
R
Carp
R I
RI
D000328:Adult; D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis; D000914:Antibodies, Viral / Q000096:biosynthesis; D006224:Cricetinae; D006801:Humans; D007118:Immunoassay / Q000379:methods; D008647:Mesocricetus; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D017096:Prion Diseases / Q000175:diagnosis* / Q000276:immunology*; D011328:Prions / Q000276:immunology*; D011817:Rabbits
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D011328:Prions