title: The use of hyperventilation and its impact on cerebral ischemia in the treatment of traumatic brain injury.
abstract: Traumatic brain injury is a common occurrence in the United States, leading to approximately 190,000 deaths or long-term disabilities. Following the primary insult, secondary disturbances in cerebral blood flow (CBF) and metabolism may have deleterious effects on potentially viable neurons. Recent studies evaluating CBF immediately following head injury have revealed flows low enough to produce cerebral ischemia. Hyperventilation is used routinely to lower suspected increased intracranial pressure (ICP). Aggressive hyperventilation produces a marked reduction in CBF, which may give rise to or exacerbate cerebral ischemia, thus enhancing rather than reducing secondary injury. This article reviews the role of hyperventilation in the treatment of increased ICP and its impact on cerebral ischemia following traumatic brain injury.
authors.affiliation: Department of Neurological Surgery, Washington University, School of Medicine, St. Louis, Missouri, USA.
authors.forename: K D
authors.initials: KD
authors.lastname: Yundt
authors.forename: M N
authors.initials: MN
authors.lastname: Diringer
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000150:complications* / Q000378:metabolism* / Q000628:therapy*; D002545:Brain Ischemia / Q000209:etiology* / Q000378:metabolism* / Q000628:therapy*; D002560:Cerebrovascular Circulation; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007427:Intracranial Pressure; D010100:Oxygen / Q000378:metabolism*; D012121:Respiration, Artificial
chemical_list: D010100:Oxygen