[The effect of cytochrome c preparations on the autoregulation of the cerebral blood flow in ischemia].
The effect of animal cytochrome C (Ca), biotechnological cytochrome (Cb) and its hemtetradecapeptide (HTDP) on cerebral blood flow autoregulation during rapid decrease of systemic arterial pressure (SAP) was studied in acute experiments on rats. Cytochrome C preparations caused no effect on the autoregulatory responses of the cerebral vessels in animals with normal cerebral circulation. Injection of 5 mg/kg Ca and Cb and 0.8 mg/kg HTDP promoted restoration of the phenomenon of cerebral blood flow autoregulation in ischemic brain damage in change of SAP from 120 to 60 mm Hg. Prophylactic injection of 20 mg/kg Ca and Cb and 3.3 mg/kg HTDP prevented cerebral blood flow autoregulation disturbance caused by transitory brain ischemia.
Pogorelyĭ
V E
VE
Gaevyĭ
M D
MD
Arl't
A V
AV
Davidov
E R
ER
Gatsura
V V
VV
D000208:Acute Disease; D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy / Q000503:physiopathology* / Q000517:prevention & control; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003574:Cytochrome c Group / Q000494:pharmacology* / Q000627:therapeutic use; D045304:Cytochromes c; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006470:Hemorrhage / Q000503:physiopathology; D006706:Homeostasis / Q000187:drug effects*; D007022:Hypotension / Q000503:physiopathology; D010446:Peptide Fragments / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D013997:Time Factors
D003574:Cytochrome c Group; D010446:Peptide Fragments; C103878:cytochrome C heme tetradecapeptide; D045304:Cytochromes c