[Effectiveness of the treatment of staphylococcal pneumonia with liposomal gentamicin in an experiment].
An in vivo comparative study on penetration of free gentamicin sulfate and liposome-entrapped gentamicin sulfate to macrophages was performed and the efficacy of the treatment of destructive pneumonia was estimated on albino mice. The liposome-entrapped antibiotic was arrested by the cells of the mononuclear phagocytic system thus providing higher concentrations of the drug in the organs with high counts of macrophages, the antibiotic retention time in the organs being longer than that after the use of free gentamicin. The use of liposome-entrapped gentamicin in the treatment of destructive pneumonia made it possible to increase the host protection from 17 to 50 per cent.
Perepelkin
A I
AI
Rotov
K A
KA
Tikhonov
N G
NG
Petrov
V I
VI
Andreev
D A
DA
D000042:Absorption; D000818:Animals; D002463:Cell Membrane Permeability; D004337:Drug Carriers; D005839:Gentamicins / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008081:Liposomes; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D011023:Pneumonia, Staphylococcal / Q000188:drug therapy*; D016896:Treatment Outcome
D004337:Drug Carriers; D005839:Gentamicins; D008081:Liposomes