A teratoid Wilms' tumor with raised serum alpha-fetoprotein level.
Tumor markers are used to diagnose certain cancers and can be useful in monitoring the response to treatment. We describe a renal tumor with the features of a teratoid nephroblastoma associated with a raised serum level of alpha-fetoprotein (AFP). The serum AFP remained high during chemotherapy but returned to normal after nephrectomy. AFP was demonstrated by immunohistochemistry in cysts lined by enteric-type epithelium within the tumor. Cytogenetic examination of the tumor showed a clone of cells with trisomy 8. Raised serum AFP has not previously been described in teratoid Wilms' tumor.
Ashworth
M T
MT
Department of Pediatric Pathology, Bristol Royal Hospital for Sick Children, United Kingdom.
Pizer
B L
BL
Oakhill
A
A
Spicer
R D
RD
Berry
P J
PJ
D001774:Blood Chemical Analysis; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000737:chemistry* / Q000473:pathology*; D013724:Teratoma / Q000737:chemistry* / Q000473:pathology*; D009396:Wilms Tumor / Q000737:chemistry* / Q000473:pathology*; D000509:alpha-Fetoproteins / Q000032:analysis* / Q000096:biosynthesis*
D000509:alpha-Fetoproteins