title: Mutation induction by high-density, 50-Hz magnetic fields in human MeWo cells exposed in the DNA synthesis phase.
abstract: Exposure of cultured human MeWo cells to high-density (400 mT at 50 Hz) extremely low frequency magnetic fields (ELF-MF) induced mutations in the hypoxanthine-guanine phosphoribosyl transferase gene. Mutation induced by the ELF-MF increased during the DNA-synthesis phase in synchronously growing cells. DNA replication errors and/or disturbance of the mismatch repair systems caused by exposure to ELF-MF may be involved in the mutagenic effect.
authors.affiliation: Department of Radiation Genetics, Faculty of Medicine, Kyoto University, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Miyakoshi
authors.forename: K
authors.initials: K
authors.lastname: Kitagawa
authors.forename: H
authors.initials: H
authors.lastname: Takebe
mesh_terms: D004247:DNA / Q000096:biosynthesis*; D004574:Electromagnetic Fields / Q000009:adverse effects*; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics*; D009154:Mutation; D016196:S Phase / Q000235:genetics; D014407:Tumor Cells, Cultured
chemical_list: D004247:DNA; D007041:Hypoxanthine Phosphoribosyltransferase