Trans-signaling by cytokine and growth factor receptors.
Although ligand-induced dimerization or oligomerization of receptors is a well established mechanism of growth factor signaling, increasing evidence indicates that biological responses are often mediated by receptor trans-signaling mechanisms involving two or more receptor systems. These include G protein-coupled receptors, cytokine, growth factor and trophic factor receptors. Greater responsiveness and inhibitory signaling responses are provided when different signaling pathways merge through receptor trans-signaling.
Castellino
A M
AM
Department of Cell Biology and Anatomy, Cornell University Medical College, New York, NY 10021, USA.
Chao
M V
MV
D000818:Animals; D002450:Cell Communication; D016207:Cytokines / Q000502:physiology*; D004815:Epidermal Growth Factor / Q000502:physiology; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000502:physiology; D046911:Macromolecular Substances; D008565:Membrane Proteins / Q000502:physiology; D018121:Receptors, Cytokine / Q000502:physiology*; D017978:Receptors, Growth Factor / Q000502:physiology*; D015398:Signal Transduction; D013917:Thrombin / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D016207:Cytokines; D006133:Growth Substances; D007328:Insulin; D046911:Macromolecular Substances; D008565:Membrane Proteins; D018121:Receptors, Cytokine; D017978:Receptors, Growth Factor; D014409:Tumor Necrosis Factor-alpha; D004815:Epidermal Growth Factor; D013917:Thrombin