title: Effect of distension and feeding on phasic changes in human proximal gastric tone.
abstract: BACKGROUND
  Proximal stomach by virtue of its property of accommodation acts as a reservoir for the ingested food, but its role in emptying and the factors modulating it remain unexplored.
  
  
  OBJECTIVE
  To assess the effects of distension and of feeding on proximal gastric tone.
  
  
  METHODS
  14 healthy volunteers with no current or past history of any gastro-intestinal symptoms.
  
  
  METHODS
  Isobaric changes in volume of the proximal stomach were recorded both during fasting and for the first 30 minutes after a meal.
  
  
  RESULTS
  For a given degree of distension, the mean (SEM) intragastric pressure was consistently lower, immediately after meal ingestion (9.8 (1.1), mm Hg) than during fasting (12.9 (0.6) mm Hg; p < 0.01). Proximal gastric tone was continuously variable with a frequency of fluctuation of 0.9-1.3/minute and an amplitude of 16.8 (2.2) ml, superimposed upon slower higher amplitude fluctuations in baseline tone. These variations in tone were unaffected by the degree of gastric distension or by food.
  
  
  CONCLUSIONS
  While proximal gastric tone decreases after meal ingestions consistent with accommodation, the fluctuations in tone are not an importance factor in the modulation of nutrient emptying from the proximal stomach in the immediate postprandial period.
authors.affiliation: Department of Medicine (Section of Gastroenterology), University of Manchester Medical School, Hope Hospital.
authors.forename: N K
authors.initials: NK
authors.lastname: Ahluwalia
authors.forename: D G
authors.initials: DG
authors.lastname: Thompson
authors.forename: J
authors.initials: J
authors.lastname: Barlow
mesh_terms: D000328:Adult; D004435:Eating / Q000502:physiology*; D005215:Fasting / Q000502:physiology; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D006801:Humans; D008297:Male; D009129:Muscle Tonus / Q000502:physiology*; D011312:Pressure; D013270:Stomach / Q000502:physiology*