title: Mitomycin-C in laser sclerostomy: benefit and complications.
abstract: OBJECTIVE
  The authors studied the effect of topical mitomycin-C administration on the maintenance of filter function and intraocular pressure (IOP) following laser sclerostomy.
  
  
  METHODS
  Twenty-six patients with a presumed high risk of episcleral scarring were treated intraoperatively with topical mitomycin-C (0.5 mg/ml) for 3 to 5 minutes. Their IOPs were monitored for at least 2 years. The IOP data of these patients were compared with the results for 46 patients who underwent the identical procedure without antimetabolite.
  
  
  RESULTS
  IOPs below 23 mm Hg were achieved in 70% of the mitomycin-C-treated patients. Compared with the non-mitomycin-C group, the rate and duration of early postoperative hypotony was significantly increased in the mitomycin-C-treated group.
  
  
  CONCLUSIONS
  Mitomycin-C is useful for maintaining successful filter function in patients with unfavorable prognoses. However, severe and persistent hypotony may occur.
authors.affiliation: University Eye Hospital Lübeck, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Schmidt-Erfurth
authors.forename: W
authors.initials: W
authors.lastname: Wetzel
authors.forename: G
authors.initials: G
authors.lastname: Dröge
authors.forename: R
authors.initials: R
authors.lastname: Birngruber
mesh_terms: D000287:Administration, Topical; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000009:adverse effects; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects / Q000502:physiology; D053685:Laser Therapy / Q000379:methods*; D016685:Mitomycin / Q000008:administration & dosage* / Q000009:adverse effects; D015814:Ocular Hypotension / Q000139:chemically induced / Q000503:physiopathology; D009883:Ophthalmic Solutions; D011183:Postoperative Complications / Q000139:chemically induced / Q000503:physiopathology; D011446:Prospective Studies; D012599:Sclerostomy / Q000379:methods*
chemical_list: D000903:Antibiotics, Antineoplastic; D009883:Ophthalmic Solutions; D016685:Mitomycin