Insulin resistance: a common factor in the triad of dyslipidemia, hypertension, and coronary artery disease?
In addition to the goal of controlling elevated blood pressure in patients with hypertension improving Dyslipidemia associated with insulin resistance may be an important element in preventing coronary artery disease. Antihypertensive treatment may differ based on the pathophysiology present. It appears that the evidence that supports the development of lipid abnormalities in patients who have insulin resistance is growing. In such patients the morbidity and mortality associated with coronary artery disease may be significantly decreased by selecting agents with favourable metabolic consequences.
Hariawala
M D
MD
Beth Israel Deaconess Medical Center and Harvard Medical School, Division of Cardiothoracic Surgery, Boston, Massachusetts 02215, USA. mukesh@bidmc.harvard.edu
Deshmukh
V V
VV
Sellke
F W
FW
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D003327:Coronary Disease / Q000209:etiology; D006801:Humans; D006949:Hyperlipidemias / Q000209:etiology; D006973:Hypertension / Q000209:etiology / Q000628:therapy; D007333:Insulin Resistance; D050356:Lipid Metabolism; D010600:Pharmacology
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents