title: Postirradiation laryngeal osteosarcoma: case report and literature review.
abstract: BACKGROUND
  Laryngeal sarcoma is a rare disease entity. In review of the literature, chondrosarcoma is the most common sarcoma, followed by fibrosarcoma. Osteosarcoma is very rare; there are only seven cases reported in the literature. Postirradiation sarcoma is a late complication of radiotherapy. Osteosarcoma is the most common type in this group. The larynx is often involved in the radiation field of treatment for head and neck malignancies. However, postirradiation laryngeal osteosarcoma has not yet been reported.
  
  
  METHODS
  We present a 56-year-old man who under went radiotherapy for nasopharyngeal carcinoma 32 years ago and later developed a laryngeal osteosarcoma.
  
  
  RESULTS
  The patient underwent total laryngectomy but died 1 year and 9 months later with locally extensive disease.
  
  
  CONCLUSIONS
  We report the first case of postirradiation laryngeal osteosarcoma. In addition to surgical treatment, adjunctive therapies should be considered for this group of patients.
authors.affiliation: Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: T S
authors.initials: TS
authors.lastname: Sheen
authors.forename: C T
authors.initials: CT
authors.lastname: Wu
authors.forename: T
authors.initials: T
authors.lastname: Hsieh
authors.forename: M M
authors.initials: MM
authors.lastname: Hsu
mesh_terms: D017809:Fatal Outcome; D005887:Gingival Neoplasms / Q000175:diagnosis / Q000532:radiotherapy* / Q000556:secondary; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000532:radiotherapy*; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis / Q000209:etiology*; D012516:Osteosarcoma / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D011882:Radiotherapy, High-Energy / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed