Temperature-sensitive repetitive discharges in paramyotonia congenita.
A 47-year-old female with paramyotonia congenita was studied with electromyography and showed minimal myotonic discharges but prominent repetitive discharges in hand muscles at room temperature. With cooling the hand, the repetitive discharges ceased as the myotonic potentials became prominent. With exercise and further cooling, the myotonic discharges increased and the strength of the muscle and recruitment pattern decreased. With warming, the myotonic discharges decreased as the repetitive discharges reappeared. This is the first report of repetitive discharges occurring in a patient with temperature-sensitive sodium channel myotonia. It is postulated that the repetitive discharges as well as the myotonic discharges are the manifestation of muscle membrane hyperexcitability secondary to the abnormal, noninactivating sodium channels.
Weiss
M D
MD
Department of Neurology, University of Maryland Hospital, Baltimore, MD 21201, USA.
Mayer
R F
RF
D004576:Electromyography; D005260:Female; D006801:Humans; D008564:Membrane Potentials / Q000502:physiology; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000737:chemistry / Q000294:innervation / Q000503:physiopathology; D009224:Myotonia Congenita / Q000503:physiopathology*; D009431:Neural Conduction / Q000502:physiology; D009475:Neurons, Afferent / Q000502:physiology; D015222:Sodium Channels / Q000502:physiology; D013696:Temperature
D015222:Sodium Channels