Accelerated gastric emptying in hypertensive subjects.
The phenomenon of accelerated gastric emptying has been previously reported in two conditions that are considered to be part of the insulin-resistance syndrome: namely, noninsulin-dependent diabetes (NIDDM) and increased body mass index (BMI). No previous studies have assessed the rate of gastric emptying in patients with essential hypertension, another disease considered to be part of the insulin-resistance syndrome.


METHODS
Scintigraphic gastric emptying studies were performed on nine hypertensive subjects and on nine sex-, age-, ethnicity and BMI-matched controls.


RESULTS
Subjects with hypertension had significantly more rapid gastric half-emptying times (gastric T50) (40.0 +/- 6.9 min versus 56.6 +/- 3.7 min, p = 0.02) than controls. There was an inverse relationship between average glucose during the first 30 min and 60 min of the oral glucose tolerance test with the gastric half-emptying time (Spearman rank correlation coefficient rs = -0.64, p = 0.0045 and rs = -0.48, p = 0.0428, respectively).


CONCLUSIONS
The occurrence of accelerated gastric emptying in hypertensive subjects, in addition to that previously reported in subjects with NIDDM or increased BMI, suggests the possibility that accelerated gastric emptying may be a common finding in insulin resistant states.
Phillips
W T
WT
Department of Radiology, University of Texas Health Science Center at San Antonio 78284-7800, USA.
Salman
U A
UA
McMahan
C A
CA
Schwartz
J G
JG
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D005260:Female; D005746:Gastric Emptying / Q000502:physiology; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D013671:Technetium Tc 99m Sulfur Colloid
D001786:Blood Glucose; D007328:Insulin; D013671:Technetium Tc 99m Sulfur Colloid