title: Ménétrier's disease evaluated serially by abdominal ultrasonography.
abstract: We report the case of a 3-year-old boy with Ménétrier's disease who presented with prominent anasarca associated with hypoproteinemia, but no proteinuria. An early sonogram of the stomach demonstrated thickening of the gastric wall which was found to resolve gradually on serial sonograms. Consequently, we considered that the submucosal layer of the gastric wall was particularly thickened as a result of Ménétrier's disease. A gastric biopsy was performed 18 days after onset of the disease, and an electron-microscopic examination of the sample disclosed persistent widening of gastric tight junctions by more than 10 nm. The patient made a full recovery on supportive treatment in 3 weeks. Ultrasonography provided us with a potent tool not only in making the diagnosis, but also in following the course of the disease.
authors.affiliation: Department of Pediatrics, Kansai Medical University, Fumizonocho 10-15, Moriguchi, Osaka 570, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Takaya
authors.forename: Y
authors.initials: Y
authors.lastname: Kawamura
authors.forename: M
authors.initials: M
authors.lastname: Kino
authors.forename: Y
authors.initials: Y
authors.lastname: Kawashima
authors.forename: A
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
mesh_terms: D000005:Abdomen / Q000000981:diagnostic imaging*; D001706:Biopsy; D002675:Child, Preschool; D004487:Edema / Q000473:pathology; D005500:Follow-Up Studies; D005748:Gastric Fundus / Q000000981:diagnostic imaging / Q000473:pathology; D005753:Gastric Mucosa / Q000000981:diagnostic imaging / Q000473:pathology; D005758:Gastritis, Hypertrophic / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007019:Hypoproteinemia / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D011507:Proteinuria; D013270:Stomach / Q000000981:diagnostic imaging; D019108:Tight Junctions / Q000648:ultrastructure; D014463:Ultrasonography