title: A teratoid Wilms' tumor with raised serum alpha-fetoprotein level.
abstract: Tumor markers are used to diagnose certain cancers and can be useful in monitoring the response to treatment. We describe a renal tumor with the features of a teratoid nephroblastoma associated with a raised serum level of alpha-fetoprotein (AFP). The serum AFP remained high during chemotherapy but returned to normal after nephrectomy. AFP was demonstrated by immunohistochemistry in cysts lined by enteric-type epithelium within the tumor. Cytogenetic examination of the tumor showed a clone of cells with trisomy 8. Raised serum AFP has not previously been described in teratoid Wilms' tumor.
authors.affiliation: Department of Pediatric Pathology, Bristol Royal Hospital for Sick Children, United Kingdom.
authors.forename: M T
authors.initials: MT
authors.lastname: Ashworth
authors.forename: B L
authors.initials: BL
authors.lastname: Pizer
authors.forename: A
authors.initials: A
authors.lastname: Oakhill
authors.forename: R D
authors.initials: RD
authors.lastname: Spicer
authors.forename: P J
authors.initials: PJ
authors.lastname: Berry
mesh_terms: D001774:Blood Chemical Analysis; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000737:chemistry* / Q000473:pathology*; D013724:Teratoma / Q000737:chemistry* / Q000473:pathology*; D009396:Wilms Tumor / Q000737:chemistry* / Q000473:pathology*; D000509:alpha-Fetoproteins / Q000032:analysis* / Q000096:biosynthesis*
chemical_list: D000509:alpha-Fetoproteins