Arthritis syndromes associated with human T cell lymphotropic virus type I infection.
Arthritis syndromes occur associated with HTLV-I infection both in the presence and in the absence of clinical ATL, and polyarthritis may be the presenting manifestation of HTLV-I-associated ATL. In both clinical settings, HTLV-I-infected T cells home to affected joints, and tax-transgenic mouse studies have suggested a pathogenic role for the HTLV-I tax gene in inducing synovial cell proliferation in HAA. Understanding the pathogenesis of rheumatoid arthritis-like arthritis syndromes that occur in the setting of HTLV-I infection should also provide insights into understanding of cellular and molecular mechanisms of synovial cell proliferation in HTLV-I-negative rheumatoid arthritis.
McCallum
R M
RM
Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Patel
D D
DD
Moore
J O
JO
Haynes
B F
BF
D000818:Animals; D001168:Arthritis / Q000235:genetics / Q000473:pathology / Q000503:physiopathology / Q000821:virology; D001170:Arthritis, Infectious / Q000235:genetics / Q000473:pathology / Q000503:physiopathology / Q000821:virology*; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000473:pathology / Q000503:physiopathology / Q000821:virology; D002455:Cell Division; D016355:Genes, pX / Q000235:genetics; D015490:HTLV-I Infections / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D008822:Mice, Transgenic; D008967:Molecular Biology; D013577:Syndrome; D013583:Synovial Membrane / Q000473:pathology / Q000821:virology