Two cases of Merkel cell carcinoma cured by intratumor injection of natural human tumor necrosis factor.
Two patients were treated with intratumor injection of natural human tumor necrosis factor for recurrent or primary Merkel cell carcinoma. In both patients, local chemotherapy achieved complete tumor regression without causing ulceration or scarring. These results suggest that intratumor injection of natural human tumor necrosis factor may be very effective for the treatment of Merkel cell carcinoma.
Hata
Y
Y
Department of Plastic Surgery, Kagawa Medical School, Japan.
Matsuka
K
K
Ito
O
O
Matsuda
H
H
Furuichi
H
H
Konstantinos
A
A
Nuri
B
B
D000368:Aged; D015266:Carcinoma, Merkel Cell / Q000628:therapy*; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D012074:Remission Induction; D012878:Skin Neoplasms / Q000628:therapy*; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage*
D014409:Tumor Necrosis Factor-alpha