title: Reed-Sternberg cells and "bystander" lymphocytes in lymph nodes affected by Hodgkin's disease are infected with different strains of Epstein-Barr virus.
abstract: In most cases of Epstein-Barr virus (EBV)-associated Hodgkin's disease (HD), EBV-positive Reed-Sternberg (RS) cells and rare EBV-positive reservoir lymphocytes coexist in lymph nodes. Here we show that, in two cases of EBV-associated HD, strains infecting RS cells and reservoir lymphocytes of the same patient have different BNLF-1 genes. This suggests that RS cells and reservoir lymphocytes of the same patient are infected by different EBV strains.
authors.affiliation: Centre d'Immunopathologie et de Génétique Humaine, CNRS UPR8291, Toulouse, France.
authors.forename: F
authors.initials: F
authors.lastname: Meggetto
authors.forename: P
authors.initials: P
authors.lastname: Brousset
authors.forename: J
authors.initials: J
authors.lastname: Selves
authors.forename: G
authors.initials: G
authors.lastname: Delsol
authors.forename: B
authors.initials: B
authors.lastname: Mariame
mesh_terms: D000818:Animals; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006689:Hodgkin Disease / Q000821:virology*; D006801:Humans; D008198:Lymph Nodes / Q000821:virology; D008214:Lymphocytes / Q000821:virology; D051379:Mice; D016513:Mice, SCID