title: [Differentiated carcinoma in autonomously functioning thyroid nodule: case report].
abstract: This paper report a case of autonomously functioning thyroid nodule, firstly occurred in a 13 years old women, complicated 9 years later by hyperthyroidism, with no response to thyreostatic treatment, hystologically diagnosed as papillary carcinoma, in a thyroid gland affected by Hashimoto's thyroiditis, with cervical bilateral lymph node metastasis. In literature the rate of coexisting hyperthyroidism, chronic thyroiditis and differentiated carcinoma is low; thus thyroid malignancies are very rare in young people. In this patient the large autonomously functioning nodule was entirely made of neoplastic tissue, while in the remaining thyroid there was no evidence of adenomatous tissue. Moreover, thyreostatic treatment failed in controlling hyperthyroidism. The Authors consider these facts as indirect evidences that this is a rare case of hyperfunctioning differentiated thyroid carcinoma.
authors.affiliation: Divisione ORL e Chirurgia Cervico-Facciale, Instituto Regina Elena per lo studio e la cura dei tumori, Roma.
authors.forename: M
authors.initials: M
authors.lastname: Ducci
authors.forename: M
authors.initials: M
authors.lastname: Appetecchia
authors.forename: A
authors.initials: A
authors.lastname: Marzetti
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000150:complications / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000209:etiology; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D013961:Thyroid Gland / Q000473:pathology / Q000601:surgery*; D013964:Thyroid Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery*; D013967:Thyroiditis, Autoimmune / Q000209:etiology