Morphological and histochemical changes in the liver of albino Wistar rat given flupenthixol depot.
Histological findings and histoenzymatic reactions have shown that Flupenthixol Depot (FPX dep.) injected to rats in therapeutic doses induced morphologically observable degenerative lesions in the liver. No significant difference in the intensity of the lesions between the groups of male and female animals was found.
Kasacka
I
I
Department of Histology and Embriology, Medical Academy of Białystok.
D000818:Animals; D002467:Cell Nucleus / Q000473:pathology; D003593:Cytoplasm / Q000473:pathology; D005260:Female; D005475:Flupenthixol / Q000031:analogs & derivatives* / Q000633:toxicity; D006003:Glycogen / Q000032:analysis; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008297:Male; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014149:Tranquilizing Agents / Q000633:toxicity*
D014149:Tranquilizing Agents; C007761:flupenthixol decanoate; D006003:Glycogen; D010744:Phosphoric Monoester Hydrolases; D005475:Flupenthixol