title: Gender-specific correlation of platelet ionized magnesium and serum low-density-lipoprotein cholesterol concentrations in apparently healthy subjects.
abstract: We previously found an inverse correlation between platelet ionized magnesium concentration ((Mg2+)i) and serum total cholesterol concentration in normal male but not female subjects. In the present study, we determined the platelet (Mg2+)i by using a fluorescent ionized magnesium (Mg2+) indicator, FURAPTRA, and measured the serum concentrations of the following: total cholesterol; very-low-density lipoprotein cholesterol (VLDL-C); low-density lipoprotein cholesterol (LDL-C); high-density lipoprotein cholesterol (HDL-C); antioxidized low-density lipoprotein (LDL) autoantibodies; lipoprotein(a); apolipoproteins A-I (apo A-I) and B (apo B); triglycerides; estradiol-17 (E2); ceruloplasmin (Cp); and selected electrolytes, including total and ionized magnesium and calcium and total protein and albumin. In men, but not in women, platelet (Mg2+)i significantly inversely correlated with serum total cholesterol (r = -0.52, p < 0.02), LDL-C (r = -0.54, p < 0.009 by a "direct" method; r = -0.40, p < 0.05 by an electrophoretic method), and apo B (r = -0.42, p < 0.04). We found no significant correlations between platelet (Mg2+)i and any other variables, including serum total and ionized magnesium, antioxidized LDL autoantibodies, Cp, and E2. We speculate that decreased platelet (Mg2+)i is a possible marker for platelet membrane alterations that may affect platelet involvement in thrombosis and atherogenesis.
authors.affiliation: Clinical Pathology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892-1508, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Niemela
authors.forename: G
authors.initials: G
authors.lastname: Csako
authors.forename: M N
authors.initials: MN
authors.lastname: Bui
authors.forename: R J
authors.initials: RJ
authors.lastname: Elin
mesh_terms: D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood / Q000502:physiology; D001055:Apolipoproteins B / Q000097:blood / Q000502:physiology; D001792:Blood Platelets / Q000737:chemistry / Q000502:physiology*; D002118:Calcium / Q000032:analysis / Q000502:physiology; D008076:Cholesterol, HDL / Q000097:blood / Q000502:physiology; D008078:Cholesterol, LDL / Q000097:blood / Q000502:physiology*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood / Q000502:physiology; D008274:Magnesium / Q000032:analysis / Q000502:physiology*; D008297:Male; D012727:Sex Characteristics; D018709:Statistics, Nonparametric
chemical_list: D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D008274:Magnesium; D002118:Calcium