title: [The efficacy and mechanisms of action of lerivon in alcoholism].
abstract: Clinico-biological examination of 50 alcoholic patients was carried out. 30 patients were treated with lerivon (L) during 1 month. 15 control patients received amitriptylin for 1 month and 15 patients received relanium for 7 days. It was determined that L was quite effective in treatment of depression in alcoholic patients. The main L effects were anxiolytic, antidepressive and hypnotic. The drug also decreased alcohol addiction, had vegetostabilising and sedative effects. The conclusion was made on pathogenetic action of L in alcoholism: It influences upon dopaminergic mediation in catecholamine system. Administration of L permitted to normalize neurochemical processes underlying alcohol addiction and depression. L was well tolerated. Side effects complications, drug addiction were not registered.
authors.forename: N N
authors.initials: NN
authors.lastname: Ivanets
authors.forename: I P
authors.initials: IP
authors.lastname: Anokhina
authors.forename: B M
authors.initials: BM
authors.lastname: Kogan
authors.forename: V V
authors.initials: VV
authors.lastname: Chirko
authors.forename: T P
authors.initials: TP
authors.lastname: Nebarakova
authors.forename: A V
authors.initials: AV
authors.lastname: Rusinov
mesh_terms: D000293:Adolescent; D000328:Adult; D000427:Alcohol Deterrents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D000437:Alcoholism / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D000639:Amitriptyline / Q000627:therapeutic use; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003975:Diazepam / Q000627:therapeutic use; D000431:Ethanol / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008803:Mianserin / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy
chemical_list: D000427:Alcohol Deterrents; D014151:Anti-Anxiety Agents; D000929:Antidepressive Agents, Tricyclic; D000639:Amitriptyline; D008803:Mianserin; D000431:Ethanol; D003975:Diazepam