Colchicine poisoning: report of a fatal case and presentation of an HPLC procedure for body fluid and tissue analyses.
A case involving a suicidal overdose resulting from the ingestion of colchicine tablets is presented. The drug was quantitated using liquid chromatography. The femoral blood level was 62 ng/mL, and the maximum concentration found in bile was 2921 ng/mL. Therefore, bile appears to be the sample of choice for toxicological analysis when a poisoning case involving colchicine is suspected.
Kintz
P
P
Institut de Médecine Légale, Strasbourg, France.
Jamey
C
C
Tracqui
A
A
Mangin
P
P
D000328:Adult; D001646:Bile / Q000737:chemistry; D001826:Body Fluids / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003078:Colchicine / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D062787:Drug Overdose; D017809:Fatal Outcome; D008401:Gas Chromatography-Mass Spectrometry; D006074:Gout Suppressants / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D006801:Humans; D008297:Male; D013405:Suicide; D014018:Tissue Distribution
D006074:Gout Suppressants; D003078:Colchicine