[Post-mortem concentration of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI-1) in the vitreous body of the human eye].
After sudden death the blood remains fluid and after late death the thrombi are present in heart and vasa. Earlier we observed after sudden death high concentrations of t-PA Ag in plasma with strong activation of fibrinolysis, consumption of PAI-1, plasminogen, fibrinogen, alfa-2 antiplasmin and a big increase of FDP. Fibrinolysis is mainly regulated by t-PA, u-PA and PAI-1.


OBJECTIVE
The aim of our study was the evaluation of t-PA and PAI-1 in corpus vitreous and plasma of patients after sudden (26) and late death (12).


METHODS
The concentration of t-PA Ag was measured with COA SET of Kabi Vitrum and the activity of PAI-1 with reagents of Biopool.


RESULTS
In corpus vitreous the concentration of t-PA after sudden death was 3.65 +/- 1.83 ng/ml and after late death 1.93 +/- 1.63 ng/ml. The activity of PAI-1 was respectively 0.61 +/- 1.2 IU/ml and 2.25 +/- 3.30 IU/ml. After sudden death the concentration of t-PA was twice higher and PAI-1 three times lower as after late death.


CONCLUSIONS
No dependence of t-PA concentration and the time after death could be observed.
Przygońska
J
J
Katedry i Zakladu Medycyny Sadowej AM w Bydgoszczy.
Kotschy
M
M
Sliwka
K
K
Kulwas
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003645:Death, Sudden / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis*; D011180:Postmortem Changes; D010959:Tissue Plasminogen Activator / Q000032:analysis*; D014822:Vitreous Body / Q000737:chemistry*
D017395:Plasminogen Activator Inhibitor 1; D010959:Tissue Plasminogen Activator