[Hypertensive cardiac damage in heart transplantation. A noninvasive monitoring study of arterial pressure].
This study is aimed at investigating the relationship between cardiac hypertrophy and blood pressure (BP) 24-h pattern in 34 heart transplanted patients (HTP), 9 out of them (26%) being considered as normotensives, the other ones (74%) being regarded as hypertensives under adequate treatment, via casual sphygmomanometry. The study is an attempt to explain the occurrence of at least one sign of hypertrophic cardiopathy in 20 cases (59%), hypothesizing the presence of false normotensives among the putative normotensives and presumably-cured hypertensives. The ambulatory BP monitoring was able to identify 7 hypertensives (78%) among the putative normotensives, and 17 not well-cured subjects (68%) among the presumably cured hypertensives. At least one sign of cardiac hypertrophy was found in 5 (50%) of the 10 true normotensives, who were all non-dipper, and in 15 (63%) of the 24 hypertensives. The 9 hypertensives without cardiac hypertrophy (37%) had developed hypertension very recently. These findings stress the role of the ambulatory BP monitoring as a diagnostic tool during the follow-up of HTP, in order to identify the false normotensives as well as the not well-treated hypertensives. This role can contribute to optimize the prophylaxis of hypertensive damage for the transplanted heart.
Cugini
P
P
Semeiotica e Metodologia Medica, Università La Sapienza, Roma.
Chiera
A
A
Petrangeli
C M
CM
Capodaglio
P F
PF
Voci
P
P
Laurenti
A
A
Papalia
U
U
Marino
B
B
Scibilia
G
G
D000328:Adult; D018660:Blood Pressure Monitoring, Ambulatory / Q000706:statistics & numerical data; D006332:Cardiomegaly / Q000175:diagnosis* / Q000209:etiology; D004359:Drug Therapy, Combination; D004452:Echocardiography / Q000706:statistics & numerical data; D005260:Female; D005500:Follow-Up Studies; D016027:Heart Transplantation / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000175:diagnosis*; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis* / Q000209:etiology
D007166:Immunosuppressive Agents