Vitamin E modifies neither fructosamine nor HbA1c levels in poorly controlled diabetes.
OBJECTIVE
To examine the effects of vitamin E on total serum protein glycation (fructosamine), hemoglobin glycation (HbA1c), and serum levels of glucose, total cholesterol, triglycerides, LDL-C, HDL-C, apolipoprotein A1 and apolipoprotein B.


METHODS
Sixty poorly controlled diabetic patients were randomly assigned to receive either 1200 mg/day of vitamin E or identical placebo capsules during a two month period following a double blind cross-over design with a four week wash-out period between regimens.


RESULTS
Seven patients were excluded from the study because of reasons not related to the medication. In the remaining 53 patients, the levels of serum glucose, fructosamine, HbA1c, total cholesterol, HDL-C, LDL-C, Apo A1 and Apo B did not vary significantly with vitamin E as compared with placebo.


CONCLUSIONS
No significant effects of vitamin E on any of the parameters evaluated were observed in poorly controlled diabetic patients.
Gómez-Pérez
F J
FJ
Department of Diabetes and Lipid Metabolism, Instituto Nacional de la Nutrición Salvador Zubirán, México, D.F.
Valles-Sanchez
V E
VE
López-Alvarenga
J C
JC
Choza-Romero
R
R
Ibarra Pascuali
J J
JJ
González Orellana
R
R
Pérez Ortiz
O B
OB
Rodríguez Padilla
E G
EG
Aguilar Salinas
C A
CA
Rull
J A
JA
D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D018592:Cross-Over Studies; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D019270:Fructosamine / Q000097:blood*; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D014810:Vitamin E / Q000494:pharmacology / Q000627:therapeutic use*
D001786:Blood Glucose; D019270:Fructosamine; D006442:Glycated Hemoglobin; D008074:Lipoproteins; D014280:Triglycerides; D014810:Vitamin E