title: Mechanism of initiation of atrial flutter in humans: site of unidirectional block and direction of rotation.
abstract: OBJECTIVE
  Using a standardized induction protocol, we investigated the mechanism of initiation of atrial flutter, before ablation, to determine the site of initiating unidirectional block and to test the hypothesis that the direction of rotation of atrial flutter depends on the pacing site from which it initiates.
  
  
  BACKGROUND
  The high recurrence rate of atrial flutter after presumed successful ablation may be due to difficulty in reinduction after termination. In addition, induction of clockwise flutter is currently of unknown clinical importance.
  
  
  METHODS
  Ten patients with documented typical flutter were studied before ablation. A standard protocol consisting of single and double extrastimuli followed by burst pacing was performed from four sites in the right atrium (high and low trabeculated and smooth right atrium) to assess efficacy at inducing atrial flutter. A 20-pole halo catheter placed around the tricuspid annulus and a decapole catheter placed in the coronary sinus were used for mapping during initiation to determine type of flutter induced and the site of unidirectional block during initiation.
  
  
  RESULTS
  Atrial flutter was induced in 52 (6.2%) of 838 attempted inductions. Of these, 33 were counterclockwise and 20 were clockwise. Of the 20 inductions resulting in clockwise flutter, 18 were from the trabeculated right atrium, whereas all the counterclockwise inductions were from the smooth right atrium. In all but the two inductions, the site of unidirectional block was identified between the os of the coronary sinus and the low lateral right atrium for both counterclockwise and clockwise flutter, in the same isthmus at which ablation is targeted.
  
  
  CONCLUSIONS
  Even in patients with clinical counterclockwise flutter, clockwise flutter is frequently induced before ablation and is dependent on the site of induction: Pacing from the smooth right atrium induces counterclockwise flutter, whereas pacing from the trabeculated right atrium induces clockwise flutter. The site of the unidirectional block during the initiation of either form of flutter is in the low right atrium isthmus.
authors.affiliation: Section of Cardiac Electrophysiology, University of California San Francisco, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Olgin
authors.forename: J M
authors.initials: JM
authors.lastname: Kalman
authors.forename: L A
authors.initials: LA
authors.lastname: Saxon
authors.forename: R J
authors.initials: RJ
authors.lastname: Lee
authors.forename: M D
authors.initials: MD
authors.lastname: Lesh
mesh_terms: D000368:Aged; D001282:Atrial Flutter / Q000503:physiopathology* / Q000628:therapy; D017115:Catheter Ablation; D006801:Humans; D008875:Middle Aged; D012399:Rotation