Tranilast suppresses the vascular intimal hyperplasia after balloon injury in rabbits fed on a high-cholesterol diet.
Intimal hyperplasia is a serious problem after percutaneous transluminal coronary angioplasty. In this study, we assessed the effect of tranilast on vascular intimal hyperplasia after balloon injury in rabbits fed on a high-cholesterol diet. In this animal model, intimal hyperplasia more severe than that in rabbits fed on a normal diet was observed. In addition, medial thickening and lipid deposits in both media and intima were also noted. These findings indicate that balloon injury caused intimal and medial hyperplasia and that this hyperplasia was accelerated by the high cholesterol load. Tranilast (300 mg/kg) significantly decreased the intimal area, medial area, and stenosis ratio, and increased the luminal/total area ratio, in the cholesterol-fed rabbits. These results suggest that tranilast may be useful for prevention of restenosis after percutaneous transluminal coronary angioplasty of patients, including those with a clinical risk of hypercholesterolemia.
Fukuyama
J
J
Pharmacological Laboratories, Kissei Pharmaceutical Co., Ltd., Hotaka, Minamiazumi, Nagano, Japan.
Ichikawa
K
K
Hamano
S
S
Shibata
N
N
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D002404:Catheterization / Q000009:adverse effects*; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D003327:Coronary Disease / Q000628:therapy; D006965:Hyperplasia; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000473:pathology; D011817:Rabbits; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D018926:Anti-Allergic Agents; D002791:Cholesterol, Dietary; D062367:ortho-Aminobenzoates; C012293:tranilast