Intravenous versus oral corticosteroids in the management of acute asthma in children.
OBJECTIVE
To determine whether oral corticosteroids are significantly better at preventing the need for hospital admission than i.v. corticosteroids in children with moderate to severe asthma exacerbation.


METHODS
We carried out a randomized, double-blind, controlled trial of patients in the emergency department of a tertiary urban children's hospital. Patients who presented to the ED with moderate to severe asthma (defined as forced expiratory volume in 1 second [FEV1] < 60% predicted for height in patients aged 7 to 18 years and as Pulmonary Index Score [PIS] between 6 and 11 for patients aged 18 months through 6 years). Patients were randomized to receive 2 mg/kg oral methylprednisolone or 2 mg/kg i.v. methylprednisolone 30 minutes after the initial treatment with nebulized albuterol. Each patient was otherwise treated with an identical regimen of frequent nebulized albuterol and i.v. theophylline for a total of 4 hours.


RESULTS
Forty-nine patients were enrolled. Four hours after treatment, both groups had similar respiratory rates, oxygen saturation, PISs, and FEV1 values. Eleven of 23 patients in the oral group (48%) and 13 of 26 patients in the i.v group (50%) were admitted to the hospital (P = .88). The 90% confidence interval for the 2% cifference in admission rate to the hospital (favoring oral methylprednisolone) ranged from 21% (favoring i.v. methylpredinisolone) to 25% (favoring oral methylprednisolone). Patients discharged home demonstrated greater improvement from baseline with regard to PIS and FEV1 than patients who were admitted. Two patients in each group failed to complete the standard treatment or returned to the hospital within 48 hours of ED discharge.


CONCLUSIONS
These data suggest that for children with moderate to severe asthma exacerbation, hospital admission rates are similar in children given oral methylprednisolone and those given i.v. methylprednisolone.
Barnett
P L
PL
Division of Emergency Medicine, Children's Hospital, Boston, Massachusetts, USA.
Caputo
G L
GL
Baskin
M
M
Kuppermann
N
N
D000284:Administration, Oral; D000293:Adolescent; D000420:Albuterol / Q000008:administration & dosage; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D013806:Theophylline / Q000008:administration & dosage; D016896:Treatment Outcome; D014797:Vital Capacity / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D001993:Bronchodilator Agents; D013806:Theophylline; D000420:Albuterol; D008775:Methylprednisolone