[Preparation of fiber materials containing both the immobilized proteolytic enzyme and antimicrobial substance, and study of their properties].
Properties of joint immobilization of a proteolytic enzyme (terrilytin, trypsin, collytin, or protease C) and an anti-microbe compound to cellulose copolymer containing carboxyl groups were investigated. It was established that the molecule of anti-microbe substance containing a few base groups enhanced stability of the enzyme immobilized, most likely due to additional fixation of the enzyme macromolecule. Changes in activity of the materials containing both protease and anti-microbe compound were studied upon gamma-sterilization and subsequent prolonged storage. The materials with combined biological action were demonstrated to accelerate markedly wound cleansing and healing.
Virnik
A D
AD
Skokova
I F
IF
Iudanova
T N
TN
Khomiaakov
K P
KP
Ivanova
M V
MV
Sedov
A V
AV
Tolstykh
P I
PI
Gostintsev
V K
VK
Arutiunian
B N
BN
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015169:Colony Count, Microbial; D010450:Endopeptidases / Q000737:chemistry / Q000302:isolation & purification*; D004800:Enzymes, Immobilized / Q000737:chemistry / Q000302:isolation & purification*; D006868:Hydrolysis; D013210:Staphylococcus / Q000187:drug effects / Q000254:growth & development; D013242:Sterilization
D000900:Anti-Bacterial Agents; D004800:Enzymes, Immobilized; D010450:Endopeptidases