Prevention of NSAID-gastropathy.
The role is reviewed of gastric antisecretory and mucosal protective drugs in the prevention of NSAID-induced gastric and duodenal mucosal lesions. The results of the randomized, double-blind, controlled trials show that misoprostol is the only antiulcer drug proven to be effective in the prevention of NSAID-induced gastric and duodenal ulcers as well as for reducing serious upper gastrointestinal complications (perforation and/or haemorrhage). However, recent data suggest that even omeprazole and high dose of H2-receptor antagonists may have a role in the prevention of NSAID-induced gastric and duodenal ulcerations.
Ardizzone
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Divisione di Gastroenterologia, Ospedale L. Sacco, Polo Universitario, Milano, Italy.
Bianchi Porro
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D000328:Adult; D000367:Age Factors; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000139:chemically induced* / Q000517:prevention & control*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D016595:Misoprostol / Q000627:therapeutic use; D009853:Omeprazole / Q000627:therapeutic use; D010438:Peptic Ulcer Hemorrhage / Q000517:prevention & control; D010439:Peptic Ulcer Perforation / Q000517:prevention & control; D012307:Risk Factors; D012795:Sialoglycoproteins / Q000627:therapeutic use; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000517:prevention & control*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D012795:Sialoglycoproteins; D016595:Misoprostol; C009354:sulglicotide; D009853:Omeprazole