Connective tissue metabolism in scleroderma, including cytokines.
The recent literature on scleroderma emphasizes the importance of cytokine dysregulation, cell-cell interactions, and extracellular matrix overproduction in the pathogenesis of this disease. Advances in our understanding of these areas are discussed here.
Unemori
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Connective Therapeutics Incorporated, Palo Alto, CA 94303, USA.
Amento
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D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D002455:Cell Division; D003238:Connective Tissue / Q000502:physiology; D016207:Cytokines / Q000502:physiology*; D004727:Endothelium / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology*; D005347:Fibroblasts / Q000502:physiology; D006801:Humans; D012595:Scleroderma, Systemic / Q000209:etiology* / Q000503:physiopathology*
D016207:Cytokines