title: [Detection of tuberculosis in children of new risk groups and efficacy of chemoprophylaxis].
abstract: 109 children at risk of tuberculosis frequently suffering from acute respiratory diseases (ARD) and 87 children with rare ARD have undergone a 3-month course of isoniazide chemoprophylaxis. In 95.0% of the examinees the above chemoprophylaxis lowered ARD morbidity to 1-2 times a year, reduced and stabilized tuberculin sensitivity, prevented tuberculosis. Isoniazide treatment of 87 children whose parents worked with cattle that might be infected prevented tuberculosis in them, diminished tuberculin sensitivity. It is thought valid that chemoprophylaxis should be given in sanatoria primarily to children exposed to two and more risk factors (epidemiological, age-sex, medicobiological, social).
authors.affiliation: Central NII of Tuberculosis RAMN, Moscow.
authors.forename: L A
authors.initials: LA
authors.lastname: Mitinskaia
authors.forename: V F
authors.initials: VF
authors.lastname: Elufimova
authors.forename: N V
authors.initials: NV
authors.lastname: Iukhimenko
authors.forename: N D
authors.initials: ND
authors.lastname: Demeshko
authors.forename: M P
authors.initials: MP
authors.lastname: Altynova
authors.forename: G A
authors.initials: GA
authors.lastname: Kufakova
mesh_terms: D000293:Adolescent; D000995:Antitubercular Agents / Q000627:therapeutic use*; D018890:Chemoprevention / Q000379:methods*; D002648:Child; D005500:Follow-Up Studies; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use*; D009017:Morbidity; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D014374:Tuberculin Test; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid