[The stress-protector properties of new analogs of mediator amino acids].
Stress-protective effect of phosphonglycerid and acyl analogs of neurotransmitter amino acids, which displayed nootropic activity was obtained. These compounds exerted positive influence on behavioral failure and morphological statement after 18-h immobilization. Dilithium-N-acetyl-L-aspartic acid (AKF-94) and di(3-dimethoxyphosphorylpropyl) ester of N-acetyl-DL-aspartic acid (PIR-87-6-0) displayed the most expressive activity. Previously activating influence of these compounds at excitatory amino acid transmission had been shown. We supposed participation of this way in stress-protective effect of new compounds.
Petrov
V I
VI
Grigor'ev
I A
IA
Adzhienko
V L
VL
Ianitskaia
A V
AV
D000311:Adrenal Glands / Q000187:drug effects / Q000473:pathology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003975:Diazepam / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D018697:Nootropic Agents / Q000627:therapeutic use*; D010889:Piracetam / Q000627:therapeutic use; D051381:Rats; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D013997:Time Factors
D014151:Anti-Anxiety Agents; C103877:N-acetylaspartic acid di(3-dimethoxyphosphorylpropyl) ester; D018697:Nootropic Agents; D001224:Aspartic Acid; D003975:Diazepam; D010889:Piracetam