Biological comparison between three clones of Trypanosoma cruzi and the strain of origin (Bolivia) with reference to clonal evolution studies.
After isolating three clones of Trypanosoma cruzi (Bolivia), we first characterized them according to parasitaemia, pleomorphism and virulence, and then histopathologically. The study's interest lies on the hypothesis that clonal evolution of T. cruzi has a major impact on biologically relevant properties of this parasite. Data obtained from the studies of parasitaemia, pleomorphism and virulence showed no differences between the groups studied. As a final point, the histopathological study shows us a muscular tissue tropism both in clones and in their mother strain (Bolivia). In this paper, we conclude that Bolivia strain and clones isolated from it, pertaining to the same major clone share similar biological properties.
Penin
P
P
Departamento de Medicina Preventiva y Salud Pública, Universidad Autónoma de Madrid, España.
Gamallo
C
C
de Diego
J A
JA
D000818:Animals; D002999:Clone Cells; D018740:Genetic Heterogeneity; D008297:Male; D051379:Mice; D018485:Muscle Fibers, Skeletal / Q000473:pathology; D018482:Muscle, Skeletal / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D018512:Parasitemia; D014349:Trypanosoma cruzi / Q000166:cytology / Q000235:genetics* / Q000472:pathogenicity; D014774:Virulence