title: [Percutaneous "high risk" angioplasty with prophylactic cardiopulmonary support. High risk PTCA with mechanical circulatory support].
abstract: With improved technology and development of several mechanical assist devices, the indications of percutaneous transluminal coronary revascularization have been extended. In 39 patients (30 men, mean age = 60.1 +/- 8.1 years) with angina pectoris or heart failure, with poor operative risk-benefit ratio and ejection fraction < 35% and/or target vessel supplying > 50% of the viable myocardium, we performed assisted percutaneous transluminal coronary revascularization. Intraortic balloon counterpulsation (n = 16), extracorporal circulation (n = 21), or hemopump (n = 2) were used for mechanical support. Complete 6-week follow up was possible in 27 patients. An improvement of left-ventricular function (patients with EF < or = 35% demonstrated an improvement: 27 +/- 7 vs 36 +/- 10%, p < 0.05), heart failure (patients with EF < or = 35% demonstrated an improvement of maximal oxygen uptake: 14 +/- 4 vs 17 +/- 4 ml/kg/min; p < 0.05) and a marked improvement of angina (23/38 demonstrated CCS-improvement of at least one class) was found. Hospital mortality was as low as 2.6%. Major postinterventional complications included nonfatal myocardial infarction (n = 2), fatal retroperitoneal bleeding (n = 1), pulmonary edema (n = 1), nonfatal ventricular fibrillation (n = 1), cerebrovascular event without residual (n = 1), and deep vein thrombosis (n = 4). In conclusion, assisted percutaneous revascularization was successful in a high risk subset of patients with increased surgical risk and/or poor ventricular function.
authors.affiliation: I. Medizinische Klinik Charité, Humboldt-Universitáat zu Berlin.
authors.forename: A C
authors.initials: AC
authors.lastname: Borges
authors.forename: F R
authors.initials: FR
authors.lastname: Waldenberger
authors.forename: C
authors.initials: C
authors.lastname: Wolf
authors.forename: I
authors.initials: I
authors.lastname: Reindl
authors.forename: D
authors.initials: D
authors.lastname: Habedank
authors.forename: M
authors.initials: M
authors.lastname: Haisjackl
authors.forename: W J
authors.initials: WJ
authors.lastname: Kox
authors.forename: W
authors.initials: W
authors.lastname: Konertz
authors.forename: G
authors.initials: G
authors.lastname: Baumann
authors.forename: F X
authors.initials: FX
authors.lastname: Kleber
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary; D001243:Assisted Circulation; D002423:Cause of Death; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013318:Stroke Volume / Q000502:physiology; D015996:Survival Rate; D016896:Treatment Outcome