Lipid-laden macrophage infiltration of human adenocarcinoma in vivo associated with taxol and GCSF treatment.
This brief report illustrates the presence of lipid-laden macrophages in proximity to metastatic adenocarcinoma cells within the bone marrow of a patient receiving taxol and GCSF therapy. The pathophysiological mechanism is uncertain. Taxol, which is associated with macrophage function in vitro, may have been responsible for the recruitment of macrophages in this patient. GCSF could have contributed as well; however, GCSF usually has little effect on monocytes and macrophages.
Abramson
N
N
Baptist Regional Cancer Institute, Baptist Medical Center, Jacksonville, Florida, USA.
Castro
S
S
Goldstein
J D
JD
D000230:Adenocarcinoma / Q000276:immunology / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001856:Bone Marrow Examination; D019046:Bone Marrow Neoplasms / Q000276:immunology / Q000473:pathology / Q000556:secondary*; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D050356:Lipid Metabolism; D008175:Lung Neoplasms / Q000473:pathology / Q000628:therapy; D008264:Macrophages / Q000378:metabolism / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D016179:Granulocyte Colony-Stimulating Factor; D017239:Paclitaxel