A comparison of the bioavailability of oral and intramuscular dexamethasone in women in late pregnancy.
OBJECTIVE
To compare the bioavailability of oral and intramuscular (i.m.) dexamethasone in third-trimester pregnant women.


METHODS
Oral and i.m. dexamethasone levels were compared in a randomized, parallel, crossover bioavailability study involving 11 gravid women in the third trimester of pregnancy. Subjects were randomized to receive either 6 mg of i.m. or 8 mg of oral dexamethasone. The following week, the alternative regimen was administered. Serial blood samples were obtained after drug administration. Dexamethasone concentrations were measured by radioimmunoassay. Total area under the curve was compared for the oral and i.m. groups using a paired t test.


RESULTS
Eight of the 11 women completed the study through 12 hours; all 11 women completed the study through 6 hours. Among the 11 women, peak levels of dexamethasone occurred 30 minutes after i.m. injection (mean +/- standard deviation, 101.7 +/- 19.2 ng/mL) and 120 minutes after oral administration (65.9 +/- 20.5 ng/mL). Area under the curve did not differ significantly between those receiving i.m. dexamethasone (258.3 +/- 50.0 ng/minute/mL) and those receiving oral dexamethasone (251.8 +/- 59.7 ng/minute/mL) when measured 6 hours after administration of the drug. Terminal half-lives were similar in the i.m. and oral groups. Similar findings were noted among the eight women who were studied through 12 hours. This study had a power of 87% to detect a 20% difference in area under the curve between the two groups.


CONCLUSIONS
The bioavailability of 8 mg of oral dexamethasone is similar to that of a 6-mg IM dose, as determined by the area under the curve.
Egerman
R S
RS
Department of Obstetrics and Gynecology, University of Tennessee, Memphis, USA.
Pierce
W F
WF
Andersen
R N
RN
Umstot
E S
ES
Carr
T L
TL
Sibai
B M
BM
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001682:Biological Availability; D018592:Cross-Over Studies; D003907:Dexamethasone / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D011247:Pregnancy; D011263:Pregnancy Trimester, Third
D003907:Dexamethasone