Bactericidal activity, post antibiotic effect and modified controlled effective regrowth time of meropenem at high concentrations.
The effect of increasing meropenem concentrations up to 250 mg/L, as might occur if 3 g was given as a single daily intravenous dose, was investigated in terms of bactericidal activity, post antibiotic effect (PAE) and modified controlled effective regrowth time (mCERT). Increasing the meropenem concentration above 50 mg/L did not result in increased bacterial killing, while concentrations over 75 mg/L did not result in longer PAE or mCERT.
Bowker
K E
KE
Bristol Centre for Antimicrobial Research & Evaluation, Southmead Health Services NHS Trust, UK. lesassays@ukneqasaa.win-uk.net
Holt
H A
HA
Reeves
D S
DS
MacGowan
A P
AP
D004754:Enterobacter / Q000187:drug effects / Q000254:growth & development; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000254:growth & development*; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000254:growth & development*; D007700:Kinetics; D007709:Klebsiella / Q000187:drug effects / Q000254:growth & development; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013845:Thienamycins / Q000494:pharmacology*
D013845:Thienamycins; D000077731:Meropenem