title: [Recurrent goiter: analysis of 134 reinterventions].
abstract: Reoperative surgery for thyroid disease still plays a predominant role in the treatment of goiter recurrences. At the moment, neither useful biological nor clinical indicators exist to prevent such recurrences. The effectiveness of TSH-suppressive therapy is still debatable and some authors have proposed total thyroidectomy for this benign disease in order to eliminate the risk of relapse. We analyzed 134 patients who underwent reintervention for recurrence of goitre in order to: 1) study possible clinical or epidemiological characteristics that could influence recurrence, 2) to verify the indications to reoperation, and 3) to evaluate the incidence of complications. For the study of complications, we adopted as a control group a series of 361 patients operated on by the same medical staff and undergoing subtotal thyroidectomy for multinodular goitre, with a minimal follow-up of 10 years. The surgical technique is described and several peculiarities are discussed. In the group of patients who had reoperation two cases (1.5%) of laryngeal palsy and two cases (1.5%) of hypoparathyroidism were recorded and this was not significantly different from the control group. A positive correlation was found between recurrence and young age at the time of first surgery (p < 0.006), female sex (p = 0.045) and esthetic results (p = 0.013). No further clinical recurrence was found in 101 patients after a mean follow-up of 122 months, while in 16 cases the echography revealed nodules in the residual parenchyma. In our opinion total thyroidectomy is not justified as a first standard procedure for this benign disease caused by the activity of various not yet well understood, growth factors.
authors.affiliation: Istituto di Clinica Chirurgica e Terapia Chirurgica, Università degli Studi di Genova.
authors.forename: G C
authors.initials: GC
authors.lastname: Torre
authors.forename: G
authors.initials: G
authors.lastname: Borgonovo
authors.forename: A
authors.initials: A
authors.lastname: Arezzo
authors.forename: D
authors.initials: D
authors.lastname: Bruzzone
authors.forename: G L
authors.initials: GL
authors.lastname: Ansaldo
authors.forename: M
authors.initials: M
authors.lastname: Puglisi
authors.forename: F P
authors.initials: FP
authors.lastname: Mattioli
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006042:Goiter / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012086:Reoperation