title: DIR: a novel DNA rearrangement associated with inverted repeats.
abstract: A novel DNA rearrangement has been characterised that is both a direct and inverted repeat. This rearrangement involves the 2-fold duplication of a plasmid sequence adjacent to the site of insertion of a long palindrome. The sequence of this rearrangement suggests that it has arisen by strand slippage from the leading to the lagging strand of the replication fork as a consequence of the presence of the long palindrome.
authors.affiliation: Institute of Cell and Molecular Biology, University of Edinburgh, Kings Buildings, Edinburgh EH9 3JR, UK.
authors.forename: D J
authors.initials: DJ
authors.lastname: Pinder
authors.forename: C E
authors.initials: CE
authors.lastname: Blake
authors.forename: D R
authors.initials: DR
authors.lastname: Leach
mesh_terms: D015245:Deoxyribonuclease BamHI / Q000378:metabolism; D015246:Deoxyribonuclease EcoRI / Q000378:metabolism; D004587:Electrophoresis, Agar Gel; D004591:Electrophoresis, Polyacrylamide Gel; D015321:Gene Rearrangement; D016254:Mutagenesis, Insertional; D010957:Plasmids; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D015245:Deoxyribonuclease BamHI; D015246:Deoxyribonuclease EcoRI