[The age-dependent incidence of Down's syndrome and the free-radical theory].
Age-dependent distribution of Down syndrome frequency in the light of free-radical theory of aging was carried out in this work. The frequency of Down syndrome had been analysed during the period of 1990-1995. The investigation of radical process intensity was performed in the group of women of child-bearing age by the chemoluminescence method. It has been demonstrated that the age of a woman is one of the main reasons both of Down syndrome frequency increase and free radical accumulation. The obtained analogy between age-dependent distribution of Down syndrome frequency and age-dependent accumulation of free radicals is one more argument for the role of free radicals in the pathogenesis of Down syndrome.
Arbuzova
S B
SB
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000097:blood; D004314:Down Syndrome / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005609:Free Radicals / Q000097:blood*; D006801:Humans; D015994:Incidence; D008163:Luminescent Measurements; D008423:Maternal Age; D008875:Middle Aged; D011247:Pregnancy; D014455:Ukraine / Q000453:epidemiology
D005609:Free Radicals