Prevention of simian immunodeficiency virus, SIVsm, or HIV-2 infection in cynomolgus monkeys by pre- and postexposure administration of BEA-005.
OBJECTIVE
To study the possibilities and limitations of postexposure treatment to prevent the establishment of infection after accidental exposure to HIV.


METHODS
The effect of 2,3'-dideoxy-3'-hydroxymethyl cytidine (B1 A-005) was investigated on acute simian immunodeficiency virus (SIV) and HIV-2 infections in macaques in pre- and postexposure treatment experiments.


RESULTS
Postexposure treatment with BLA-005 (3 x 10 mg/kg) for as short as 3 days prevented infection with SIVsm after intravenous or rectal inoculation. Infection with HIV-2 could also be blocked by postexposure BFA-005 treatment.


CONCLUSIONS
This study shows that therapeutic intervention can block early systemic and mucosal infections with SIV and HIV-2. Further evaluation is ongoing.
Böttiger
D
D
Microbiology and Tumour Biology Centre, Karolinska Institute, Stockholm, Sweden.
Johansson
N G
NG
Samuelsson
B
B
Zhang
H
H
Putkonen
P
P
Vrang
L
L
Oberg
B
B
D000818:Animals; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D003562:Cytidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015658:HIV Infections / Q000517:prevention & control* / Q000821:virology; D015498:HIV-2 / Q000302:isolation & purification*; D008252:Macaca fascicularis; D016097:Simian Acquired Immunodeficiency Syndrome / Q000517:prevention & control*
C105895:2',3'-dideoxy-3'-hydroxymethyl cytidine; D019380:Anti-HIV Agents; D000998:Antiviral Agents; D003562:Cytidine