Evans' syndrome associated with Graves' disease.
A 36-year-old woman who had had Graves' disease for 6 years was admitted with severe thrombocytopenia. Evans' syndrome was diagnosed. The patient's family history showed multiple cases of Graves' disease but no cases of Evans' syndrome. Both conditions in this patient improved with corticosteroid and thiamazole therapy. Several autoimmune antibodies were found, but a common autoimmune mechanism was not clearly shown. Although the combination of Graves' disease and Evans' syndrome had not occurred previously in her family, genetic factors may play an important role in the pathogenesis of both conditions.
Yashiro
M
M
Third Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki.
Nagoshi
H
H
Kasuga
Y
Y
Isobe
H
H
Kitajima
S
S
Nakagawa
T
T
Ohshima
J
J
Ide
K
K
Someya
K
K
Saito
N
N
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications*; D013956:Antithyroid Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006111:Graves Disease / Q000150:complications* / Q000188:drug therapy / Q000235:genetics; D006801:Humans; D008713:Methimazole / Q000008:administration & dosage*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications*; D013577:Syndrome
D000305:Adrenal Cortex Hormones; D013956:Antithyroid Agents; D008713:Methimazole