title: CSF inositol does not predict antidepressant response to inositol. Short communication.
abstract: CSF inositol was reported to be reduced in depression and inositol has been reported to be effective in treatment of depression. We studied CSF inositol in 18 drug-free depressed patients and 36 normal controls; the depressed patients then participated in an open trial of 18 gm daily inositol treatment for 4 weeks. There was no difference in pre-treatment CSF inositol between depressed patients and controls. CSF inositol levels did not predict response on the Hamilton Depression Scale to 4 weeks of inositol treatment.
authors.affiliation: Ministry of Health Mental Health Center. Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Levine
authors.forename: L
authors.initials: L
authors.lastname: Kurtzman
authors.forename: A
authors.initials: A
authors.lastname: Rapoport
authors.forename: J
authors.initials: J
authors.lastname: Zimmerman
authors.forename: Y
authors.initials: Y
authors.lastname: Bersudsky
authors.forename: J
authors.initials: J
authors.lastname: Shapiro
authors.forename: R H
authors.initials: RH
authors.lastname: Belmaker
authors.forename: G
authors.initials: G
authors.lastname: Agam
mesh_terms: D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000134:cerebrospinal fluid* / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy*; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007294:Inositol / Q000134:cerebrospinal fluid* / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D000928:Antidepressive Agents; D007294:Inositol