[Ovarian stimulation using a protocol of low dose agonist in patients with an elevated basal FSH].
This study compare the ovarian response of patients with high day 3 FSH (> 6.5 UI/L), treated with two protocols; a protocol with a low dose of GnRH agonist and a so called "long protocol" with GnRH agonist in a depot formula. The ovarian response with the agonist low dose was better with less ampules (37.1 vs 46.6) and a shorter duration of stimulation (10.5 vs 12.4 days). The number of mature oocyte was higher (5.9 vs 4.5) as well as the number of good quality embryo (3.2 versus 2.3). The E2 levels on day 8 was higher (1065 vs 460 pg/ml). The cancellation rate was lower (14% vs 26%). The use of the low dose protocol gave a better ovarian response for patients with high 3 FSH. Large randomized studies are needed to confirm these data.
Olivennes
F
F
Service de Gynécologie-Obstétrique, Hôpital Antoine-Béclère, Clamart.
Righini
C
C
Fanchin
R
R
Torrisi
C
C
Hazout
A
A
Glissant
M
M
Fernandez
H
H
Frydman
R
R
D000328:Adult; D002985:Clinical Protocols; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000188:drug therapy*; D008186:Luteolytic Agents / Q000627:therapeutic use*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D017329:Triptorelin Pamoate / Q000627:therapeutic use*
D008186:Luteolytic Agents; D017329:Triptorelin Pamoate; D005640:Follicle Stimulating Hormone