title: Unilateral vestibular neuritis with otolithic signs and off-vertical axis rotation.
abstract: Off-vertical axis rotation (OVAR) at constant velocity is a dynamic otolith stimulus that induces horizontal and vertical eye movement responses. To determine the value of this examination as a test for unilateral otolithic hypofunction, we compared the OVAR responses of patients suffering from acute vestibular neuritis (VN) without any sign of otolith affection, with those of patients suffering from acute VN with otolithic signs. The horizontal eye movement bias component shows directional preponderance (DP) significantly higher in patients with otolithic signs than in patients not presenting them. However, as bias DP also reflects the imbalance between right and left horizontal canals activity, this greater bias DP could be explained by the more severe canals impairment-evaluated by caloric test-found in patients with otolithic signs. No significant difference can be shown on horizontal modulation. The DP of vertical modulation is significantly higher in patients presenting otolithic signs than in patients not presenting them: in the case of otolithic signs, the responses are smaller during rotations toward the affected side. Therefore, this variable could be used as an indication of unilateral otolithic hypofunction.
authors.affiliation: ENST, URA CNRS 820, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Darlot
authors.forename: M
authors.initials: M
authors.lastname: Toupet
authors.forename: P
authors.initials: P
authors.lastname: Denise
mesh_terms: D000328:Adult; D005133:Eye Movements / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009443:Neuritis / Q000175:diagnosis* / Q000503:physiopathology; D009759:Nystagmus, Pathologic / Q000175:diagnosis / Q000503:physiopathology; D010037:Otolithic Membrane / Q000503:physiopathology*; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology; D014717:Vertigo / Q000175:diagnosis / Q000503:physiopathology; D015837:Vestibular Diseases / Q000175:diagnosis* / Q000503:physiopathology; D014724:Vestibular Function Tests; D014725:Vestibular Nerve / Q000503:physiopathology*