Unrelated peripheral blood stem cell transplantation for Fanconi anemia.
The Brazilian unrelated bone marrow donor program began in 1993 and an unrelated matched donor was found for a Fanconi anemia patient without a sibling match. An 11-year-old female recipient received FTBI (6.0 Gy) and cyclophosphamide (40 mg/kg) as conditioning. The 41-year-old female unrelated donor received G-CSF at 5 micrograms/kg x 5 days, and on day 6 and 7 postmobilization, peripheral blood stem cells were harvested. Engraftment was seen on day 19 post-BMT and she remains alive and well on day 191+. This case supports the potential role of harvesting G-CSF-stimulated PBSC for unrelated bone marrow transplantation.
Massumoto
C
C
Department of Hematology, Fundação Pró-Sangue/Hemocentro de São Paulo, Brazil.
Moraes
J R
JR
Moraes
M E
ME
Macedo
M C
MC
Medeiros
R
R
Chamone
D
D
Dulley
F
F
D002648:Child; D005199:Fanconi Anemia / Q000628:therapy*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D014184:Transplantation, Homologous