HIV-1 disease association with HLA-DQ antigens in African Americans and Caucasians.
Previously, we have shown that CD4 levels in African Americans infected with human immunodeficiency virus-1 (HIV-1) were lower than those in Caucasians. To determine whether or not HLA type is associated with susceptibility to HIV-1 infection, we demonstrated serologically that HLA-DQ6(1) and HLA-DQ7(3) were associated with HIV-1 infection in both African Americans and Caucasians. The present investigation was designed to demonstrate whether or not HLA-DQB1 alleles were associated with HIV-1 infection or protection from infection within these two ethnic groups. Oligonucleotide typing was employed and results were analyzed by chi 2 with Fisher's exact test to compare HLA-DQ marker frequencies in the regional control population (98 African Americans, 143 Caucasians) to the disease population (n = 52; 30 African Americans and 22 Caucasians). We found a statistically significant increased risk of HIV infection associated with HLA-DQB1*0605 in African Americans, and with HLA-DQB1*0602 in Caucasians. By contrast, HLA-DQB1*0603 was associated with protection in Caucasians.
Achord
A P
AP
Department of Pathology, University of Mississippi Medical Center, Jackson 39216, USA.
Lewis
R E
RE
Brackin
M N
MN
Henderson
H
H
Cruse
J M
JM
D000293:Adolescent; D000328:Adult; D044383:Black People / Q000235:genetics*; D004198:Disease Susceptibility; D005819:Genetic Markers; D015658:HIV Infections / Q000209:etiology / Q000235:genetics* / Q000276:immunology*; D015497:HIV-1; D006683:HLA-DQ Antigens / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D044465:White People / Q000235:genetics*; D001741:Black or African American
D005819:Genetic Markers; D006683:HLA-DQ Antigens