[Complete cholesteryl ester transfer protein deficiency increases oxidized-LDL in plasma].
Malondialdehyde-modified LDL(MDA-LDL) is one of the major oxidative LDL. MDA-LDL was determined by enzyme immunoassay in patients with complete and partial cholesteryl ester transfer protein(CETP) deficiency. Significantly increased serum MDA-LDL levels and MDA-LDL/apoB ratios in the LDL fraction were observed in patients with complete CETP deficiency but not for those with partial CETP deficiency. The present results may indicate that patients with complete CETP deficiency have a higher risk for atherosclerosis than those with partial CETP deficiency and normal.
Chiba
H
H
Department of Laboratory Medicine, Medical Hospital, Hokkaido University School of Medicine, Sapporo.
Akita
H
H
Kotani
K
K
Kanno
T
T
Manabe
M
M
D001161:Arteriosclerosis / Q000097:blood / Q000209:etiology; D002352:Carrier Proteins / Q000378:metabolism*; D053480:Cholesterol Ester Transfer Proteins; D005260:Female; D006023:Glycoproteins; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood* / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D012306:Risk
C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D006023:Glycoproteins; D008077:Lipoproteins, LDL