title: Nicardipine as antihypertensive therapy in liver transplant recipients: results of long-term use.
abstract: Arterial hypertension is frequent in liver transplant recipients on cyclosporine A (CsA). Nicardipine is a calcium channel blocker (CCB) that has been shown to be efficient in controlling postoperative hypertension. However, its use has been limited in organ recipients because of its reported interaction with CsA metabolism. In this report, we studied the results of the long-term use of nicardipine after liver transplantation. Forty-nine consecutive liver transplant recipients with a follow-up longer than 2 years were studied. Immunosuppressive regimen was based on CsA and prednisone. Patients with immediate postoperative hypertension received intravenous nicardipine, secondarily switched to oral nicardipine (group 1, n = 27). Patients with delayed hypertension (i.e., >2 weeks posttransplant) received other antihypertensive drugs which did not interact with CsA metabolism. These patients and those without hypertension formed group 2 (n = 22). The two groups were similar for age, sex, body weight, and transplantation indications. Interaction of nicardipine with CsA metabolism was confirmed. Whereas cyclosporine blood levels were similar in both groups at any time during the study, the mean cyclosporine daily dose required to achieve such levels was 30% lower in group 1 compared with group 2 (P < .01). This resulted in a significant cost-containment. The use of nicardipine was not associated with an increased incidence of graft rejection or CsA toxicity episodes. The results in liver transplant recipients showed that nicardipine interacts with CsA metabolism, leading to a 30% reduction in CsA dose and does not increase the risk of CsA toxicity or graft rejection. Nicardipine can be used safely for the treatment of arterial hypertension after liver transplantation with a potential cost-containment.
authors.affiliation: Service d'Hépatologie et de Gastroentérologie, Hôpital Henri Mondor,Créteil, France.
authors.forename: C
authors.initials: C
authors.lastname: Duvoux
authors.forename: D
authors.initials: D
authors.lastname: Cherqui
authors.forename: V
authors.initials: V
authors.lastname: Di Martino
authors.forename: J M
authors.initials: JM
authors.lastname: Métreau
authors.forename: A
authors.initials: A
authors.lastname: Salvat
authors.forename: J Y
authors.initials: JY
authors.lastname: Lauzet
authors.forename: P L
authors.initials: PL
authors.lastname: Fagniez
authors.forename: D
authors.initials: D
authors.lastname: Dhumeaux
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D016572:Cyclosporine / Q000009:adverse effects* / Q000191:economics; D016527:Drug Costs; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy*; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000191:economics; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009529:Nicardipine / Q000627:therapeutic use*
chemical_list: D000959:Antihypertensive Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D009529:Nicardipine