title: Diversity and evolution of the DRB1*03 family: description of DRB1*03022,*0307,*0308.
abstract: Three previously unreported DRB1*03 alleles are described, adding to the diversity of the DRB1 family of alleles. DRB1*03022 contains a silent substitution at codon 77. DRB1*0307 differs from DRB1*03011 by a substitution at codon 26 resulting in a predicted change from tyrosine to phenylalanine. DRB1*0308 is almost identical to DRB1*03011 differing at codon 58 which specifies the glutamic acid residue commonly found in DRB1*11 alleles. The new alleles (DRB1*03022,*0307,*0308) may have arisen by gene conversion-like events and add to the increasing complexity of the HLA system.
authors.affiliation: Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, District of Columbia, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Ellis
authors.forename: N
authors.initials: N
authors.lastname: Steiner
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: T T
authors.initials: TT
authors.lastname: Tang
authors.forename: C K
authors.initials: CK
authors.lastname: Hurley
mesh_terms: D000483:Alleles; D001483:Base Sequence; D018076:DNA, Complementary; D019143:Evolution, Molecular; D014644:Genetic Variation; D006684:HLA-DR Antigens / Q000145:classification / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008969:Molecular Sequence Data
chemical_list: D018076:DNA, Complementary; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains