title: [Relation between the conformation and antioxidant properties in a series of topochemical analogs of carnosine and carcinine with different N-acyl substitutes].
abstract: To elucidate the influence of the nature of N-acyl substituent on antioxidant properties of carcinine analogs, the corresponding histamine derivatives were synthesized. Antioxidant activity of the compounds prepared was investigated in the Fe(2+)-ascorbate-dependent system of oxidation of the linoleic acid micellar solution. Conformations of carnosine, carcinine, and their analogs were calculated by the molecular mechanics MM+ method. The structural elements and conformations that are preferable for the appearance of antioxidant activity were found.
authors.forename: E A
authors.initials: EA
authors.lastname: Rozhkova
authors.forename: S A
authors.initials: SA
authors.lastname: Ogrel'
authors.forename: D N
authors.initials: DN
authors.lastname: Grigor'ev
authors.forename: V E
authors.initials: VE
authors.lastname: Nebol'sin
authors.forename: G A
authors.initials: GA
authors.lastname: Zheltukhina
authors.forename: R P
authors.initials: RP
authors.lastname: Evstigneeva
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D002336:Carnosine / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D008958:Models, Molecular; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D002336:Carnosine; C015055:carcinine