Bacterial 3alpha-hydroxysteroid dehydrogenase is homologous to a fusion of bacterial ribosomal L10 and L7/12 genes.
3alpha-Hydroxysteroid dehydrogenase catalyzes the reversible oxidation of 3alpha-hydroxyl groups of the steroid nucleus. Sequence analysis reveals that this enzyme is homologous to ribosomal proteins L10 and L7/12. The alignment suggests that 3alpha-hydroxysteroid dehydrogenase is formed by a fusion of the two ribosomal proteins.
Baker
M E
ME
Department of Medicine, University of California, San Diego, La Jolla 92093, USA.
D015096:3-Hydroxysteroid Dehydrogenases / Q000737:chemistry* / Q000235:genetics; D045002:3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics; D008969:Molecular Sequence Data; D011549:Pseudomonas / Q000201:enzymology / Q000235:genetics; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000235:genetics; D000080882:Ribosomal Protein L10; D012269:Ribosomal Proteins / Q000737:chemistry* / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D013302:Streptomyces / Q000737:chemistry / Q000235:genetics
D001426:Bacterial Proteins; D011993:Recombinant Fusion Proteins; D012269:Ribosomal Proteins; C016700:ribosomal protein L7-L12; D015096:3-Hydroxysteroid Dehydrogenases; D045002:3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)