title: [Immune system defence and its correction in patients with chronic inflammatory disorders of lower extremities].
abstract: The factors of immune defense were studied in 83 patients. Chronic osteomyelitis of foot and shin was in 48 patients (hematogenic osteomyelitis in 36 patients, posttraumatic osteomyelitis-in 12 patients). Trophic ulcers were in 25 patients: in 36% in the presence of diabetes mellitus; diabetic angiopathy complicated with diabetic gangrene was in 10 patients. The complex of immune and morphological changes, developing chronic inflammation underlying chronic course of disease, have been detected by clinical trials. The development of immune insufficiency makes it necessary to use various methods of immunocorrection (pharmacological, biological, physical) in treatment of such patients that will decrease rate of postoperative morbidity and improve results of treatment.
authors.affiliation: Department of Common Surgery, Moscow Medical Academy of IM Sechenov.
authors.forename: V K
authors.initials: VK
authors.lastname: Gostishchev
authors.forename: V S
authors.initials: VS
authors.lastname: Paukov
authors.forename: L O
authors.initials: LO
authors.lastname: Shkrob
authors.forename: N G
authors.initials: NG
authors.lastname: Germakova
authors.forename: L P
authors.initials: LP
authors.lastname: Shalchkova
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D017719:Diabetic Foot / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007107:Immune System; D007871:Leg Ulcer / Q000276:immunology* / Q000628:therapy; D008875:Middle Aged; D010019:Osteomyelitis / Q000276:immunology* / Q000628:therapy
chemical_list: D015415:Biomarkers