A novel rapid throughput phototolerance screen in mice.
A relatively simple, rapid throughput phototolerance screen in small animals would be very useful in early drug development. It could prioritize or select potential lead compounds from among a number of analogs with similar biological activities. This study describes an in vivo mouse phototolerance screen established for that purpose. It also reports phototolerance data with standard reference drugs obtained using this screen.
Shapiro
M A
MA
Department of Infectious Diseases, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, Michigan 48105, USA.
Sesnie
J C
JC
Joannides
E T
ET
Malta
T E
TE
Dever
J A
JA
Heifetz
C L
CL
D000818:Animals; D017484:Dermatitis, Phototoxic / Q000209:etiology*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D015363:Quinolones / Q000633:toxicity; D012871:Skin Diseases / Q000139:chemically induced / Q000209:etiology; D014116:Toxicology / Q000379:methods*
D015363:Quinolones