title: Phosprenyl: a novel drug with antiviral and immunomodulatory activity.
abstract: A novel antiviral drug with immunomodulatory activity (Phosprenyl) is presented. The main active ingredient of the preparation is polyprenyl phosphates. This medicine is highly efficient against a number of viruses, including HIV in vitro, and tick-borne encephalitis and rabies viruses in the experimental models in vivo. In veterinary practice Phosprenyl is now regarded as an effective therapeutic means for treatment of canine distemper, hepatitis, enteritis, etc.
authors.affiliation: Joint-Stock Company Micro-plus, N.F. Gamaleya Research Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: L L
authors.initials: LL
authors.lastname: Danilov
authors.forename: S D
authors.initials: SD
authors.lastname: Maltsev
authors.forename: A V
authors.initials: AV
authors.lastname: Deyeva
authors.forename: A N
authors.initials: AN
authors.lastname: Narovlyansky
authors.forename: A V
authors.initials: AV
authors.lastname: Sanin
authors.forename: S V
authors.initials: SV
authors.lastname: Ozherelkov
authors.forename: A V
authors.initials: AV
authors.lastname: Pronin
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D006224:Cricetinae; D004216:Distemper / Q000188:drug therapy; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004288:Dolichol Phosphates / Q000502:physiology; D004353:Drug Evaluation, Preclinical; D004751:Enteritis / Q000188:drug therapy / Q000662:veterinary; D006524:Hepatitis, Viral, Animal / Q000188:drug therapy; D051379:Mice; D015394:Molecular Structure; D010322:Parvoviridae Infections / Q000188:drug therapy / Q000662:veterinary; D011106:Polyisoprenyl Phosphates / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D014777:Virus Diseases / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000276:Adjuvants, Immunologic; D000998:Antiviral Agents; D004288:Dolichol Phosphates; D011106:Polyisoprenyl Phosphates; C105485:phosprenyl; C028306:dolichol monophosphate