title: Hemostatic efficacy and safety of TachoComb in surgery. Ready to use and rapid hemostatic agent.
abstract: TachoComb is a new, ready-to-use hemostatic agent consisting of a collagen sheet coated on one side with human fibrinogen, bovine thrombin, and bovine aprotinin. The product was used in 125 surgical operations (vascular, hepatic, urological and ENT) in which secondary hemostasis was required. It was placed over the cut surface or over the edges of the wound. The investigating surgeons expressed their opinion on the intra- and postoperative hemostatic efficacy, and routine laboratory tests were done postoperatively. TachoComb had good hemostatic efficacy in 67.2% of cases, and very good in 22.4%. No noteworthy systemic changes were observed. As an adjuvant to obtain complete hemostasis in surgery, TachoComb is effective, practical and quick to use, and is very well tolerated.
authors.affiliation: Surgical Department, University of Milan, Italy.
authors.forename: G B
authors.initials: GB
authors.lastname: Agus
authors.forename: A V
authors.initials: AV
authors.lastname: Bono
authors.forename: E
authors.initials: E
authors.lastname: Mira
authors.forename: S
authors.initials: S
authors.lastname: Olivero
authors.forename: A
authors.initials: A
authors.lastname: Peilowich
authors.forename: E
authors.initials: E
authors.lastname: Homdrum
authors.forename: C
authors.initials: C
authors.lastname: Benelli
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D007611:Aprotinin; D016063:Blood Loss, Surgical / Q000503:physiopathology / Q000517:prevention & control; D001803:Blood Transfusion; D002417:Cattle; D004338:Drug Combinations; D005260:Female; D005340:Fibrinogen; D006488:Hemostasis, Surgical; D006801:Humans; D008297:Male; D008875:Middle Aged; D013917:Thrombin; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; C093991:tachocomb; D005340:Fibrinogen; D007611:Aprotinin; D013917:Thrombin