Molecular mechanisms of hemoglobin switching.
The developmental regulation of the human beta-globin cluster embodies all aspects of transcriptional control of eukaryotic genes. The cis-acting sequences within the cluster, distal regulatory regions and trans-acting factors all contribute to provide stringent temporal and tissue-specific expression. This review will examine the individual regulatory mechanisms which govern globin gene expression and highlight recent advances which expand our understanding of these dynamic interactions.
Jane
S M
SM
Rotary Bone Marrow Research Laboratories, Royal Melbourne Hospital, Parkville, Victoria, Australia. jane@wehi.edu.au
Cunningham
J M
JM
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D004268:DNA-Binding Proteins / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D005812:Genes, Switch; D005914:Globins / Q000235:genetics; D006454:Hemoglobins / Q000235:genetics*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D005810:Multigene Family
D004268:DNA-Binding Proteins; D006454:Hemoglobins; D005914:Globins