Evaluation of antibiotics for the elimination of the tonsillar carrier state of Streptococcus suis in pigs.
Seventy clinically normal 13-day-old crossbred pigs from 10 litters from a Streptococcus suis-infected herd were randomly assigned by litter and weight to 7 groups of 10 pigs each to determine whether different antibiotic regimens would eliminate the tonsillar carrier state of S. suis. Six antimicrobial regimens were tested: penicillin intramuscularly (IM) once daily (s.i.d.) for 3 consecutive days; penicillin IM s.i.d. for 5 consecutive days; ampicillin IM s.i.d. for 5 consecutive days; ampicillin per os s.i.d. for 5 consecutive days; ampicillin intranasally s.i.d. for 5 consecutive days; and ceftiofur sodium IM s.i.d. for 5 consecutive days. The seventh group consisted of untreated control pigs. Tonsillar swab samples were collected before treatment, and tonsillar tissue samples were collected after treatment for cultural examination for S. suis. Streptococcus suis was identified in pigs from all groups prior to treatment and after treatment. Pigs did not have clinical signs of disease during the study. All antimicrobial treatments tested in this study failed to eliminate the tonsillar carrier state of S. suis. Early weaning and medication used in this study were not effective for the elimination of the tonsillar carrier state of S. suis in pigs. Optimization of management and environment of pigs coupled with strategic medication of clinically ill animals should be used for control and prevention of mortality caused by streptococcosis.
Amass
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SF
School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
Wu
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CC
Clark
L K
LK
D000281:Administration, Intranasal; D000284:Administration, Oral; D000667:Ampicillin / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002353:Carrier State / Q000188:drug therapy / Q000662:veterinary*; D002511:Cephalosporins / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D007273:Injections, Intramuscular; D014066:Palatine Tonsil / Q000382:microbiology*; D010406:Penicillins / Q000008:administration & dosage / Q000627:therapeutic use*; D013290:Streptococcal Infections / Q000188:drug therapy / Q000662:veterinary*; D017011:Streptococcus suis / Q000145:classification / Q000302:isolation & purification; D013552:Swine; D013553:Swine Diseases
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D010406:Penicillins; D000667:Ampicillin; C053503:ceftiofur