Scavenging of hypochlorous acid by carvedilol and ebselen in vitro.
1. The antihypertensive drug carvedilol and the antiinflammatory selenoorganic compound ebselen were tested for their ability to react with the reactive oxygen species hypochlorous acid (HOCl) in vitro. 2. Carvedilol scavenges HOCl at a rate sufficient to protect a model molecule catalase against inactivation by HOCl. 3. Ebselen was resistant to HOCl when its glutathione-peroxidase mimetic property was compared with that of glutathione peroxidase.
Aruoma
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Pharmacology Group, University Of London King's College, UK.
D001393:Azoles / Q000494:pharmacology*; D002227:Carbazoles / Q000737:chemistry*; D000077261:Carvedilol; D002374:Catalase / Q000737:chemistry; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000737:chemistry; D006997:Hypochlorous Acid / Q000737:chemistry*; D054833:Isoindoles; D016566:Organoselenium Compounds / Q000494:pharmacology*; D011412:Propanolamines / Q000737:chemistry*
D001393:Azoles; D002227:Carbazoles; D016166:Free Radical Scavengers; D054833:Isoindoles; D016566:Organoselenium Compounds; D011412:Propanolamines; D000077261:Carvedilol; C042986:ebselen; D006997:Hypochlorous Acid; D002374:Catalase; D005979:Glutathione Peroxidase