title: Strategic proposals for predicting drug-drug interactions during new drug development: based on sixteen deaths caused by interactions of the new antiviral sorivudine with 5-fluorouracil prodrugs.
authors.affiliation: Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Watabe
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000009:adverse effects*; D001086:Arabinofuranosyluracil / Q000009:adverse effects / Q000031:analogs & derivatives*; D015195:Drug Design; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005472:Fluorouracil / Q000009:adverse effects*; D006562:Herpes Zoster / Q000188:drug therapy; D006801:Humans; D007564:Japan; D011355:Prodrugs / Q000009:adverse effects*; D051381:Rats; D018570:Risk Assessment
chemical_list: D000998:Antiviral Agents; D011355:Prodrugs; D001086:Arabinofuranosyluracil; C031368:sorivudine; D005472:Fluorouracil