Enhancement by neurotensin of hepatocarcinogenesis by N-nitrosomorpholine in Sprague-Dawley rats.
The effect of neurotensin on hepatocarcinogenesis by N-nitrosomorpholine (NNM) was investigated in Sprague-Dawley rats. Rats were given drinking water containing NNM for 8 weeks and alternate-day injections of neurotensin from the beginning until the end of the experiment. Preneoplastic and neoplastic lesions stained for placental type glutathione-S-transferase (GST-P) were examined histochemically. Administration of neurotensin significantly increased the percentage area and the number of GST-P-positive lesions, and the labeling indices of pre-neoplastic lesions and adjacent liver. These findings indicate that neurotensin enhances hepatocarcinogenesis and that this effect may be related to its effect in increasing cell proliferation in preneoplastic lesions.
Nakaizumi
A
A
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari-ku, Japan.
Uehara
H
H
Baba
M
M
Iishi
H
H
Tatsuta
M
M
D000818:Animals; D002273:Carcinogens; D004357:Drug Synergism; D005982:Glutathione Transferase / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000201:enzymology; D008297:Male; D009363:Neoplasm Proteins / Q000378:metabolism; D009496:Neurotensin / Q000494:pharmacology*; D009602:Nitrosamines; D051381:Rats; D017207:Rats, Sprague-Dawley
D002273:Carcinogens; D009363:Neoplasm Proteins; D009602:Nitrosamines; D009496:Neurotensin; C002741:N-nitrosomorpholine; D005982:Glutathione Transferase