Precise correlation of histopathological and fluorescein angiographic morphology using retinal vascular casting.
The histopathology of three eyes obtained post mortem from 2 patients with age-related macular degeneration was correlated with the pre mortem fluorescein angiographic morphology. A precise point-by-point correlation between histopathology and the corresponding angiographic appearance was ensured by using the cast retinal vascular system as a pattern of reference. The study showed that both the photoreceptors, the pigment epithelium, and substances accumulated between the retinal and the choroidal vascular systems, may have a blocking effect on choroidal background fluorescence as seen on fluorescein angiograms. Furthermore, it is confirmed that fluorescein angiographic hyperfluorescence may be due to a lack of blocking of the choroidal fluorescence because of a window defect in the retinal photoreceptor layer and/or the pigment epithelium.
Bek
T
T
Department of Ophthalmology, Arhus University Hospital, Denmark.
Prause
J U
JU
D000368:Aged; D016319:Corrosion Casting / Q000379:methods; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008268:Macular Degeneration / Q000473:pathology*; D008297:Male; D012160:Retina / Q000473:pathology*; D012171:Retinal Vessels / Q000473:pathology*; D012680:Sensitivity and Specificity