title: Heterocyclic analogues of quinone methide: preparation and cytotoxicity of 3-oxo-3H-pyrazolo[1,5-a]indole derivatives.
abstract: A series of 3-oxo-3H-pyrazolo[1,5-a]indole derivatives was prepared and characterized as heterocyclic analogues of quinone methide. These compounds showed some cytotoxicity to cancer cells, but were ineffective in an in vivo test against murine leukemia L1210.
authors.affiliation: Niigata College of Pharmacy, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Katayama
authors.forename: N
authors.initials: N
authors.lastname: Tagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Kawada
authors.forename: K
authors.initials: K
authors.lastname: Shiobara
authors.forename: K
authors.initials: K
authors.lastname: Kaneko
authors.forename: Y
authors.initials: Y
authors.lastname: Honda
authors.forename: N
authors.initials: N
authors.lastname: Kondo
authors.forename: Y
authors.initials: Y
authors.lastname: Ikeda
mesh_terms: D000818:Animals; D004354:Drug Screening Assays, Antitumor; D045563:Indolequinones; D007211:Indoles / Q000138:chemical synthesis*; D007939:Leukemia L1210 / Q000188:drug therapy; D008297:Male; D051379:Mice; D016685:Mitomycin / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D011809:Quinones / Q000138:chemical synthesis*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D045563:Indolequinones; D007211:Indoles; D011720:Pyrazoles; D011809:Quinones; C068040:quinone methide; D016685:Mitomycin