title: Metastatic seminoma simulating malignant lymphoma in an HIV infected hemophiliac.
abstract: Although most common, malignant lymphoma and Kaposi's sarcoma are not the only malignancies encountered in lymph nodes from HIV-infected patients. An increased frequency of testicular germ cell tumors in HIV-infected individuals has been reported. We report here the first case, to our knowledge, of a metastatic seminoma in an HIV-infected hemophiliac. The atypical clinical presentation, cervical and axillary adenopathy, simulated malignant lymphoma. The diagnosis was first suspected when a fine needle aspiration biopsy from an enlarged cervical node revealed a mixture of benign appearing lymphocytes and loosely cohesive large tumor cells in a "tigroid" background. Immunocytochemistry and a subsequent excisional biopsy confirmed the cytologic diagnosis. Metastatic germ cell tumors should be considered in the differential diagnosis of HIV-related lymphadenopathy.
authors.affiliation: Department of Pathology, University of South Florida College of Medicine, Tampa 33612, USA.
authors.forename: J I
authors.initials: JI
authors.lastname: Diaz
authors.forename: S V
authors.initials: SV
authors.lastname: Nicosia
authors.forename: J
authors.initials: J
authors.lastname: Szakacs
authors.forename: J
authors.initials: J
authors.lastname: Powsang
authors.forename: H I
authors.initials: HI
authors.lastname: Saba
mesh_terms: D000328:Adult; D003581:Cytodiagnosis; D003937:Diagnosis, Differential; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000175:diagnosis*; D008297:Male; D012074:Remission Induction / Q000379:methods; D018239:Seminoma / Q000175:diagnosis* / Q000532:radiotherapy / Q000556:secondary