title: Primary cardiac gastrinoma causing Zollinger-Ellison syndrome.
abstract: Primary cardiac tumors are rare, and there are no reports of patients with a functional gastroenteropancreatic tumor syndrome caused by such a tumor. This case report describes a patient with a cardiac gastrinoma causing Zollinger-Ellison syndrome. Evidence is presented that this tumor represents a primary cardiac tumor. The exact identification of this gastrinoma in an extra-abdominal site was facilitated by the use of [111In-DTPA-DPhe1]octreotide scanning for somatostatin receptors, which these tumors characteristically possess in high numbers. The recent availability of this novel localization method may facilitate identification of extra-abdominal sites in an increasing proportion of patients with gastrinomas and related neuroendocrine functional tumors in which no intra-abdominal primary tumor is currently found.
authors.affiliation: Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: F
authors.initials: F
authors.lastname: Gibril
authors.forename: L T
authors.initials: LT
authors.lastname: Curtis
authors.forename: B
authors.initials: B
authors.lastname: Termanini
authors.forename: M K
authors.initials: MK
authors.lastname: Fritsch
authors.forename: I A
authors.initials: IA
authors.lastname: Lubensky
authors.forename: J L
authors.initials: JL
authors.lastname: Doppman
authors.forename: R T
authors.initials: RT
authors.lastname: Jensen
mesh_terms: D000293:Adolescent; D005260:Female; D015408:Gastrinoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism; D006338:Heart Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D009206:Myocardium / Q000473:pathology; D015282:Octreotide / Q000031:analogs & derivatives; D004369:Pentetic Acid / Q000031:analogs & derivatives; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin / Q000378:metabolism; D015043:Zollinger-Ellison Syndrome / Q000209:etiology*
chemical_list: D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin; C071632:SDZ 215-811; D004369:Pentetic Acid; D015282:Octreotide