[Molecular mechanisms of cell-to-cell interactions during the progress and healing of tuberculosis].
The role of some protein systems of humoral regulation and of some lipid mediators in the development, course, and outcomes of tuberculous inflammation has been studied. The authors discuss regularities in the changes of the kallikrein-kinin system, blood clotting and fibrinolysis systems, proteinase-inhibitor balance, pool and functional activity of fibronectin in the blood and various parts of the respiratory systems, shifts in the content and ratios of prostaglandins E and F2 alpha in pulmonary tissue and bronchoalveolar space, in the level of platelet activation factor in liquid biological media and various types of phagocytizing cells. Shifts in all these systems are uniform, starting from acute-phase mobilization and eventuating in loss of autoregulation and depletion. Changes in all the above-listed systems of humoral regulation are due to the bactericidal activity of phagocytes, specific features of the cytogram of bronchoalveolar lavage, vascular permeability, morphological characteristics, and course and outcomes of the tuberculous process in the lungs.
Kaminskaia
G O
GO
Central NII of Tuberculosis RMNA, Moscow.
Abdullaev
R I
RI
Grigor'eva
E V
EV
Serebrianaia
B A
BA
D000818:Animals; D001777:Blood Coagulation; D002450:Cell Communication / Q000502:physiology*; D018450:Disease Progression; D005342:Fibrinolysis; D006801:Humans; D016234:Kallikrein-Kinin System / Q000502:physiology; D012038:Regeneration / Q000502:physiology*; D014397:Tuberculosis, Pulmonary / Q000378:metabolism* / Q000473:pathology