title: Bone resorption inhibitors from hop extract.
abstract: We searched hop extract for active component(s) that inhibited bone resorption in the pit formation assay, and isolated xanthohumol and humulone as active ingredients. Especially humulone had extraordinarily strong inhibitory activity and the IC50 (concentration of 50% inhibition) value was 5.9 x 10(-9)M.
authors.affiliation: Pharma Research and Development Division, Hoechst Japan Limited, Saitama, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tobe
authors.forename: Y
authors.initials: Y
authors.lastname: Muraki
authors.forename: K
authors.initials: K
authors.lastname: Kitamura
authors.forename: O
authors.initials: O
authors.lastname: Komiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Sugioka
authors.forename: H B
authors.initials: HB
authors.lastname: Maruyama
authors.forename: E
authors.initials: E
authors.lastname: Matsuda
authors.forename: M
authors.initials: M
authors.lastname: Nagai
mesh_terms: D001862:Bone Resorption / Q000188:drug therapy*; D053138:Cyclohexenes; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010945:Plants, Edible / Q000737:chemistry*; D011427:Propiophenones / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology
chemical_list: D053138:Cyclohexenes; D005419:Flavonoids; D010936:Plant Extracts; D011427:Propiophenones; D013729:Terpenes; C007966:humulon; C104536:xanthohumol