Consistency of a double PAPNET scan of cervical smears.
OBJECTIVE
To determine the reproducibility and accuracy of the PAPNET system in finding and presenting abnormal and atypical cells.


METHODS
To assess the potential variation of a double PAPNET scan on the same cervical smear, 516 cervical smears from women with abnormal histologic diagnoses were scanned twice via PAPNET and reviewed by two independent examiners in a double-blind trial.


RESULTS
The false negative rate of 5.7% in conventional screening was reduced to 0.4% and 0.8%, respectively, by PAPNET testing. The resulting concurrence of the first and the second PAPNET reviews was 99.2%, indicating the accuracy, sensitivity and consistency of this supplemental test.


CONCLUSIONS
The results obtained demonstrate the reproducibility and accuracy of the system in finding and presenting abnormal and atypical cells.
Jenny
J
J
Laboratory of Jacques Jenny, Zurich, Switzerland.
Isenegger
I
I
Boon
M E
ME
Husain
O A
OA
D001331:Automation; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis*; D004311:Double-Blind Method; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation*; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D008328:Man-Machine Systems; D008403:Mass Screening / Q000295:instrumentation; D016571:Neural Networks, Computer; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*; D014626:Vaginal Smears / Q000295:instrumentation*; D014741:Video Recording; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis*