High-dose 5-fluorouracil infusional therapy is associated with hyperammonaemia, lactic acidosis and encephalopathy.
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D000138:Acidosis / Q000139:chemically induced*; D000641:Ammonia / Q000097:blood*; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D001927:Brain Diseases / Q000139:chemically induced*; D003128:Coma; D003937:Diagnosis, Differential; D004569:Electroencephalography; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007262:Infusions, Intravenous; D007773:Lactates / Q000097:blood; D009369:Neoplasms / Q000188:drug therapy*; D012640:Seizures
D000964:Antimetabolites, Antineoplastic; D007773:Lactates; D000641:Ammonia; D005472:Fluorouracil