title: Polysomnographic studies in patients referred for ECT: pre-ECT studies.
abstract: Forty-one patients referred for electroconvulsive therapy (ECT) were evaluated with a standardized clinical protocol and had polysomnographic studies performed pre-ECT after 10 or more days drug free. Clinical evaluations were performed by blind investigators and included the Research Diagnostic Criteria and the Hamilton Rating Scale for Depression (HRSD). Patients were categorized according to the clinical response. Thirty patients (73%) reached a post-ECT HRSD < or = 10, whereas 21 of them (51.2%) reached a post-ECT HRSD score < or = 6. Sleep-onset rapid eye movement (SOREM) periods were present in 27 (66%) of the patients. Few polysomnographic variables differentiated between excellent responders and patients with residual symptoms. Older patients had significantly more disrupted polysomnographic study parameters. Although present in a significant proportion of patients, baseline SOREM was not a factor in outcome.
authors.affiliation: Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, USA.
authors.forename: L
authors.initials: L
authors.lastname: Grunhaus
authors.forename: J E
authors.initials: JE
authors.lastname: Shipley
authors.forename: A
authors.initials: A
authors.lastname: Eiser
authors.forename: A C
authors.initials: AC
authors.lastname: Pande
authors.forename: R
authors.initials: R
authors.lastname: Tandon
authors.forename: A
authors.initials: A
authors.lastname: Remen
authors.forename: J F
authors.initials: JF
authors.lastname: Greden
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002540:Cerebral Cortex / Q000503:physiopathology; D003866:Depressive Disorder / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D004565:Electroconvulsive Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011930:Reaction Time / Q000502:physiology; D012894:Sleep Stages / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology; D016896:Treatment Outcome