title: Case report: anti-proteinase 3 antibody activity in a patient with primary sclerosing cholangitis: clinical remission following ursodeoxycholic acid therapy.
abstract: Primary sclerosing cholangitis is rare among Chinese. We report on a 71 year old male patient who presented with clinical features consistent with the disorder. Subsequent investigations confirmed the diagnosis. The patient was found to have anti-neutrophil cytoplasmic antibodies with specificity against proteinase 3. Treatment with ursodeoxycholic acid resulted in clinical remission and disappearance of the antibodies.
authors.affiliation: Department of Medicine, Our Lady of Maryknoll Hospital, Wong Tai Sin, Kowloon, Hong Kong.
authors.forename: S S
authors.initials: SS
authors.lastname: Wong
authors.forename: J W
authors.initials: JW
authors.lastname: Lawton
mesh_terms: D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D000918:Antibody Specificity; D001324:Autoantigens / Q000276:immunology; D002756:Cholagogues and Choleretics / Q000627:therapeutic use*; D015209:Cholangitis, Sclerosing / Q000188:drug therapy* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008297:Male; D053146:Myeloblastin; D012697:Serine Endopeptidases / Q000276:immunology*; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001324:Autoantigens; D002756:Cholagogues and Choleretics; D014580:Ursodeoxycholic Acid; D012697:Serine Endopeptidases; D053146:Myeloblastin