title: Kinesin-73 in the nervous system of Drosophila embryos.
abstract: Kinesin-73 cDNA was shown to encode a kinesin heavy chain protein that contains an N-terminal motor domain and a long central region that lacks extensive coiled-coils. The amino acid sequence of the motor domain of kinesin-73 protein is most closely related to the motor domains of Caenorhabditis elegans unc-104 and mouse KIF1A. The central region of kinesin-73 protein also is related to unc-104 and KIF1A, but the homology is lower than that of the motor domain. The C-terminal region of kinesin-73 protein contains a cytoskeleton associated protein Gly-rich domain, which is a putative microtubule binding site that is present in some cytoskeleton or dynein-associated proteins. Kinesin-73 mRNA was shown by in situ hybridization to be maternally expressed and widely distributed in the syncytial blastoderm embryo. However, later in Drosophila embryo development, expression of the kinesin-73 gene becomes restricted mostly to the central and peripheral nervous systems.
authors.affiliation: Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-4036, USA.
authors.forename: H P
authors.initials: HP
authors.lastname: Li
authors.forename: Z M
authors.initials: ZM
authors.lastname: Liu
authors.forename: M
authors.initials: M
authors.lastname: Nirenberg
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D030801:Animals, Genetically Modified; D001483:Base Sequence; D003001:Cloning, Molecular; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D029721:Drosophila Proteins; D015698:Genomic Library; D017403:In Situ Hybridization; D019476:Insect Proteins / Q000235:genetics* / Q000302:isolation & purification; D016547:Kinesins / Q000235:genetics* / Q000302:isolation & purification; D051379:Mice; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000302:isolation & purification; D009420:Nervous System / Q000737:chemistry* / Q000196:embryology; D011487:Protein Conformation; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution
chemical_list: D029721:Drosophila Proteins; D019476:Insect Proteins; C104644:Khc-73 protein, Drosophila; D009419:Nerve Tissue Proteins; D016547:Kinesins