[The membrane-protective action of a new preparation of n-3 polyenic acids in the adrenaline-damaged myocardium].
We undertook this study to evaluate effects of a long-term pretreatment with a new stabilized drug preparation n-3 polyunsaturated fatty acids (PUFAs) in the development of experimental adrenalin-induced necrosis of the myocardium. It was found out that the preliminary administration of PUFAs makes for a significant reduction in the mass of the infarcted area of the myocardium. Severely manifest arrhythmias were less frequently seen in treated animals, with death rates among them being lower than in controls, and what is more, an excess activation of the biomembrane lipid peroxidation and suppression of the function of the system of antioxidant defence, occurring in necrosis of the myocardium in an experimental setting, appeared to be generally preventable. It is suggested that the ability of n-3 PUFAs to modulate the properties of the biological membranes might account for the above effects.
Kresiun
V I
VI
Minakov
O I
OI
Hodziieva
I N
IN
Tyshchenko
O V
OV
Kravchenko
L S
LS
Dzenkevych
I O
IO
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004281:Docosahexaenoic Acids / Q000627:therapeutic use*; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D015118:Eicosapentaenoic Acid / Q000627:therapeutic use*; D004837:Epinephrine; D006321:Heart / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D004338:Drug Combinations; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid; D004837:Epinephrine