Interferon-omega suppresses hepatitis B surface antigen production in human hepatoma cell line.
Biological activities of human interferon (IFN) omega are less well characterized than those of other type I human IFNs. We compared the ability of recombinant IFN-omega, IFN-alpha 2 and IFN-gamma to inhibit the production of viral hepatitis B surface antigen (HBsAg) in the human hepatoma cell line PLC/PRF/5. The results demonstrated that the capacity of IFN-omega to suppress the HBsAg synthesis was similar to that of IFN-alpha 2. The kinetics of the inhibitory effect of IFN-gamma differed from those of the two other IFNs.
Hajnická
V
V
Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
Fuchsberger
N
N
Liptáková
H
H
Stancek
D
D
Kontsek
P
P
D000998:Antiviral Agents / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular; D006514:Hepatitis B Surface Antigens / Q000096:biosynthesis*; D006515:Hepatitis B virus / Q000187:drug effects*; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000998:Antiviral Agents; D006514:Hepatitis B Surface Antigens; D007370:Interferon Type I; C063743:interferon omega 1