title: Signal transduction by members of the transforming growth factor-beta superfamily.
abstract: Transforming growth factor-beta (TGF beta) superfamily members exert their diverse biological effects through their interaction with heteromeric receptor complexes of transmembrane serine/threonine kinases. Both components of the receptor complex, known as receptor I and receptor II are essential for signal transduction. The composition of these complexes can vary significantly due to the promiscuous nature of the ligands and the receptors, and this diversity of interactions can yield a variety of biological responses. Several receptor interacting proteins and potential mediators of signal transduction have now been identified. Recent advances, particularly in our understanding of the function of Mothers against dpp-related (MADR) proteins, are providing new insights into how the TGF beta superfamily signals its diverse biological activities.
authors.affiliation: Department of Anatomy and Cell Biology, University of Toronto, Ontario, Canada. lattis@sickkids.on.ca
authors.forename: L
authors.initials: L
authors.lastname: Attisano
authors.forename: J L
authors.initials: JL
authors.lastname: Wrana
mesh_terms: D019883:Alkyl and Aryl Transferases; D000818:Animals; D015703:Antigens, CD; D002352:Carrier Proteins / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology; D051152:Clusterin; D004268:DNA-Binding Proteins / Q000502:physiology; D029721:Drosophila Proteins; D000071063:Endoglin; D039621:Eukaryotic Initiation Factor-3; D051231:Farnesyltranstransferase; D006023:Glycoproteins / Q000502:physiology; D006360:Heat-Shock Proteins / Q000502:physiology; D006801:Humans; D019476:Insect Proteins / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; D046911:Macromolecular Substances; D018832:Molecular Chaperones; D005810:Multigene Family; D011485:Protein Binding; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D011506:Proteins / Q000502:physiology; D011509:Proteoglycans / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology; D051096:Proto-Oncogene Proteins c-ret; D011940:Receptor Aggregation; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology; D011956:Receptors, Cell Surface; D018125:Receptors, Transforming Growth Factor beta / Q000145:classification / Q000502:physiology*; D015398:Signal Transduction; D051785:Smad Proteins; D022021:Tacrolimus Binding Proteins; D015534:Trans-Activators; D014157:Transcription Factors / Q000502:physiology; D014166:Transferases / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000502:physiology*; D019010:Vascular Cell Adhesion Molecule-1 / Q000502:physiology; D000099176:Noggin Protein
chemical_list: D019883:Alkyl and Aryl Transferases; D015703:Antigens, CD; D002352:Carrier Proteins; D051152:Clusterin; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D000071063:Endoglin; D039621:Eukaryotic Initiation Factor-3; D051231:Farnesyltranstransferase; D006023:Glycoproteins; D006360:Heat-Shock Proteins; D019476:Insect Proteins; D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; D046911:Macromolecular Substances; D018832:Molecular Chaperones; D017346:Protein Serine-Threonine Kinases; D011506:Proteins; D011509:Proteoglycans; D011518:Proto-Oncogene Proteins; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases; D011956:Receptors, Cell Surface; D018125:Receptors, Transforming Growth Factor beta; D051785:Smad Proteins; D022021:Tacrolimus Binding Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D014166:Transferases; D016212:Transforming Growth Factor beta; D019010:Vascular Cell Adhesion Molecule-1; D000099176:Noggin Protein; C495242:CLU protein, human; C064206:ENG protein, human; C064196:dpp protein, Drosophila; C094066:shn protein, Drosophila; C091428:sog protein, Drosophila; C071736:betaglycan; C096013:EIF3I protein, human; C054234:chordin; C416649:Ret protein, Drosophila