title: Unrelated peripheral blood stem cell transplantation for Fanconi anemia.
abstract: The Brazilian unrelated bone marrow donor program began in 1993 and an unrelated matched donor was found for a Fanconi anemia patient without a sibling match. An 11-year-old female recipient received FTBI (6.0 Gy) and cyclophosphamide (40 mg/kg) as conditioning. The 41-year-old female unrelated donor received G-CSF at 5 micrograms/kg x 5 days, and on day 6 and 7 postmobilization, peripheral blood stem cells were harvested. Engraftment was seen on day 19 post-BMT and she remains alive and well on day 191+. This case supports the potential role of harvesting G-CSF-stimulated PBSC for unrelated bone marrow transplantation.
authors.affiliation: Department of Hematology, Fundação Pró-Sangue/Hemocentro de São Paulo, Brazil.
authors.forename: C
authors.initials: C
authors.lastname: Massumoto
authors.forename: J R
authors.initials: JR
authors.lastname: Moraes
authors.forename: M E
authors.initials: ME
authors.lastname: Moraes
authors.forename: M C
authors.initials: MC
authors.lastname: Macedo
authors.forename: R
authors.initials: R
authors.lastname: Medeiros
authors.forename: D
authors.initials: D
authors.lastname: Chamone
authors.forename: F
authors.initials: F
authors.lastname: Dulley
mesh_terms: D002648:Child; D005199:Fanconi Anemia / Q000628:therapy*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D014184:Transplantation, Homologous