Mechanisms of induction of chromosomal aberrations and their detection by fluorescence in situ hybridization.
Fluorescence in situ hybridization (FISH) technique using chromosome specific probes has revolutionized the field of radiation cytogenetics in the last few years. Some of the new insights on the origins of radiation induced chromosome aberrations in human, mouse and Chinese hamster, using FISH are reviewed in this paper.
Natarajan
A T
AT
MGC Department of Radiation Genetics and Chemical Mutagenesis, Leiden University, The Netherlands.
Balajee
A S
AS
Boei
J J
JJ
Darroudi
F
F
Dominguez
I
I
Hande
M P
MP
Meijers
M
M
Slijepcevic
P
P
Vermeulen
S
S
Xiao
Y
Y
D000818:Animals; D016466:CHO Cells; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects*; D006224:Cricetinae; D003412:Cricetulus; D015342:DNA Probes; D004260:DNA Repair; D005347:Fibroblasts; D016193:G1 Phase; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*; D008214:Lymphocytes; D051379:Mice; D016192:Resting Phase, Cell Cycle; D013154:Spleen / Q000166:cytology; D014740:Vidarabine / Q000494:pharmacology
D015342:DNA Probes; D014740:Vidarabine