Caudal hindbrain neuromedin B-preferring receptors participate in the control of food intake.
Recent studies have identified two subtypes of bombesin (BN) receptors in the rat central nervous system: gastrin releasing-peptide (GRP) preferring and neuromedin B (NMB) preferring. To investigate a role for the NMB-preferring receptor subtype in feeding suppression elicited by fourth ventricular (4V) BN administration, we evaluated the ability of a selective NMB-preferring receptor antagonist, BIM-23127, to block suppression of glucose intake produced by 4V BN (10 pmol). Our results showed that 4V administration of BIM-23127 dose dependently antagonized the suppression of glucose intake produced by 4V BN. In addition, 4V administration of BIM-23127 alone increased glucose intake above that observed in the baseline condition. These results support a role for the NMB-preferring BN receptor subtype in the suppression of intake produced by 4V BN administration and suggest that endogenously released NMB participates in ingestive control.
Ladenheim
E E
EE
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. laden@welchlink.welch.jhu.edu
Taylor
J E
JE
Coy
D H
DH
Carrigan
T S
TS
Wohn
A
A
Moran
T H
TH
D000818:Animals; D001839:Bombesin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects / Q000502:physiology*; D005947:Glucose; D007276:Injections, Intraventricular; D008297:Male; D010456:Peptides, Cyclic / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018004:Receptors, Bombesin / Q000502:physiology*; D012249:Rhombencephalon / Q000378:metabolism*; D012996:Solutions
C092829:BIM 23127; D010456:Peptides, Cyclic; D018004:Receptors, Bombesin; D012996:Solutions; D005947:Glucose; D001839:Bombesin