Effects of chronic lithium and electroconvulsive stimuli on cholecystokinin mRNA expression in the rat brain.
This study compares the effect of lithium (Li+) and electroconvulsive stimuli (ECS), two treatments commonly used in the treatment of affective disorders, on CCK mRNA expression in the rat brain. Two groups of rats receiving either 4 week Li+ or vehicle food supplementation and two groups receiving 6 ECS or 6 sham ECS during 2 weeks were studied. A significant decrease in CCK mRNA levels was seen in the caudate putamen both after Li+ as compared to vehicle and ECS as compared to sham ECS, 27 and 25%, respectively. A small (10%), yet significant, decrease was also seen in the inner entorhinal cortex after Li+. The results indicate that both Li+ and ECS inhibit CCK synthesis in the caudate putamen and are consistent with other findings of presumed decreased dopaminergic action in this part of the brain following these treatments.
Zachrisson
O
O
Department of Clinical Neuroscience, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden. olofz@psyk.ks.se
Mathé
A A
AA
Lindefors
N
N
D000818:Animals; D001921:Brain / Q000187:drug effects*; D002766:Cholecystokinin / Q000187:drug effects / Q000378:metabolism*; D004597:Electroshock; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D012333:RNA, Messenger; D002766:Cholecystokinin; D008094:Lithium