title: Killing kinetics of meropenem against penicillin-resistant pneumococci.
abstract: The killing kinetics of meropenem against sixteen clinical isolates of pneumococci (12 penicillin-resistant, three penicillin-intermediate and one penicillin-sensitive) were studied. Meropenem was tested at 1x, 2x and 4x the MIC for each individual isolate. The results showed a good bactericidal activity with rapid killing of pneumococci (killing > 3 log10 cfu/mL was obtained for nine strains). This strategy needs clinical assessment and might prove to be a suitable alternative to penicillin and cephalosporins for the treatment of mixed infections involving multiresistant pneumococci.
authors.affiliation: Laboratoire Central de Microbiologie-CHU Saint-Antoine, Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Barakett
authors.forename: D
authors.initials: D
authors.lastname: Lesage
authors.forename: F
authors.initials: F
authors.lastname: Delisle
authors.forename: G
authors.initials: G
authors.lastname: Richard
authors.forename: J C
authors.initials: JC
authors.lastname: Petit
mesh_terms: D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D013845:Thienamycins / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D013845:Thienamycins; D000077731:Meropenem