Regional chemotherapy approaches for primary and metastatic liver tumors.
There are pharmacologic principles that make regional chemotherapy to the liver a logical treatment strategy. Patients with colorectal liver metastases and hepatocellular carcinoma would appear to be the best candidates for such an approach. Although there are many objective responses to such treatment, survival benefit has not been demonstrated, but new regimens and refined techniques appear to be improving results. Ultimately, regional delivery may be best suited for innovative treatments such as biologicals and gene therapies.
Venook
A P
AP
Department of Medicine, Division of Hematology/Oncology, University of California, San Francisco, USA.
Warren
R S
RS
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001688:Biological Products / Q000008:administration & dosage / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D016461:Chemoembolization, Therapeutic; D010478:Chemotherapy, Cancer, Regional Perfusion; D002985:Clinical Protocols; D003110:Colonic Neoplasms / Q000473:pathology; D015316:Genetic Therapy; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery / Q000628:therapy; D012004:Rectal Neoplasms / Q000473:pathology; D012074:Remission Induction; D015996:Survival Rate
D000970:Antineoplastic Agents; D001688:Biological Products