title: [A clinico-pharmacological basis for optimizing the treatment of therapy-resistant forms of epilepsy].
abstract: On 44 epileptic patients antiepileptic phenobarbital, finlepsin, diphenine, hexamidine were studied. The alterations in the level of free and bound fractions under the drug application in maximal tolerance daily doses, depending on changes in the administration frequency during the day, were recorded. It was established that level fluctuations of the total preparation occur mainly owing to level alterations in the fraction not bound to serum proteins. An increase in the drug administration frequency under the constant daily dose leads to a distinct reduction in the free fraction level fluctuations between doses, to a decrease in the intensity or removal of side effects, and makes it possible to further build up the daily dose to obtain the required effect.
authors.forename: S A
authors.initials: SA
authors.lastname: Gromov
authors.forename: D P
authors.initials: DP
authors.lastname: Smirnov
authors.forename: S K
authors.initials: SK
authors.lastname: Khorshev
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage* / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011485:Protein Binding; D013607:Tablets; D013997:Time Factors
chemical_list: D000927:Anticonvulsants; D001798:Blood Proteins; D013607:Tablets