[Ovulation induction in women in the in vitro fertilization program].
In-vitro fertilization presents a method of assisted reproduction where fusion of two gametes (fertilization) occurs in laboratory conditions. In this way part of the process which normally happens in the fallopian tube is being imitated. By ovulation the number of follicles increases, thus increasing the number of oocytes, that is the number of embryos and at the same time increasing chance of pregnancy. Ovulation induction was achieved by: clomiphene citrate (CC), human menopausal gonadotropin (hMG), human chorionic gonadotropin (hCG) and luteinizing hormone-releasing hormone (LHRH). Our trial compared effects of three induction schemes: HMG-hCG; CC-hMG-hCG and LHRH-hMG-hCG. We compared the following parameters: total number of follicles, number of mature follicles (16mm with simultaneous estradiol level 350pg/ml per follicle), number of aspirated oocytes as well as the number of embryos produced by insemination of aspirated oocytes. Our examination revealed that there was no significant difference in number of follicles, aspirated and produced oocytes in patients undergoing stimulated ovulation scheme CC-hMG-hCG in regard to those with hMG-hCG schemes. In patients undergoing LHRH-hMG-hCG scheme the number of follicles was decreased and there were less oocytes, but the number of developed embryos after oocytes insemination was increased. This leads to the conclusion that in-vitro fertilization depends on quality, not only the number of oocytes obtained by LHRH agonists induction.
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Klinika za ginekologiju i akuserstvo, Medicinski fakultet, Novi Sad.
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D000328:Adult; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy