Mesalamine-induced hypersensitivity pneumonitis. A case report and review of the literature.
A 49-year-old man with Crohn's disease treated with prednisone and mesalamine (5-ASA) developed worsening respiratory distress and fever. Symptoms improved after discontinuation of mesalamine. A rechallenge 3 months later caused similar pulmonary symptoms, confirming the association between the drug and the respiratory system. Mesalamine may cause hypersensitivity pneumonitis in patients with Crohn's disease.
Sviri
S
S
Division of Medicine, Hadassah University Hospital, Jerusalem, Israel.
Gafanovich
I
I
Kramer
M R
MR
Tsvang
E
E
Ben-Chetrit
E
E
D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced* / Q000175:diagnosis; D000636:Aminosalicylic Acids / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy; D008297:Male; D019804:Mesalamine; D008875:Middle Aged
D000636:Aminosalicylic Acids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine