[The pathophysiological significance of the low triiodothyronine syndrome with increased clearance in cancer of the stomach and large intestine].
Investigations designed to study T3 pharmacokinetics under malignant tumors of the stomach and large intestine showed an augmented total T3 clearance, which fact is indicative of enhancement of the processes of 5-monodeiodezing of thyroid hormones. It is to be thought that intensification of T3 metabolism and rise in inverse T3 produced through peripheral conversion of T4 underlie the pathogenesis of that low triiodothyronine syndrome to be encountered in malignant tumors. Since the above mechanism of development of low T3 syndrome has been identified in traumata and infectious diseases, the changes in question might be considered to be one of the links in the general adaptive syndrome directed towards satisfaction of the phagocytosing leucocytes' requirements in the biocydic substrate iodine and augmentation of the production of the fat-mobilizing factor inverse T3.
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D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000601:surgery; D007420:Intestine, Large; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000601:surgery; D013577:Syndrome; D013607:Tablets; D013997:Time Factors; D014284:Triiodothyronine / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics
D013607:Tablets; D014284:Triiodothyronine