The effect of a pulsed magnetic field and that of methyl-silane triol on galactosamine induced hepatitis among rats.
Liver cell necrosis was induced in rats by a galactosamine injection. Cell death was due to an increase of Ca++ intracellular levels and was also under the control of genes. Rats were then either exposed or not to a 6 mT 100 HZ pulsed magnetic field (PMF) and they either received or not methylsilane-triol injections. Animals were sacrificed twenty-seven hours after a galactosamine injection. On the one hand it appeared from transaminase levels that the PMF increased the number of animals which were sensitized to galactosamine but decreased transaminase levels. On the other hand PMF decreased the protective effect of MST against galactosamine. We may suggest that PMF should be considered as an additional cellular signal received through genes which would determine the evolution towards or against apoptosis according to the age of the cell itself but also the Ca++ intracellular level.
Bellossi
A
A
Laboratoire de Biophysique, Faculté de Médecine, Rennes, France.
Nawrocki
T
T
Pouvreau-Quillien
V
V
Arulmozhi
V
V
Rocher
C
C
Ruelloux
M
M
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000628:therapy*; D005688:Galactosamine / Q000633:toxicity*; D008280:Magnetics; D008297:Male; D017646:Organosilicon Compounds / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012459:Salicylates / Q000494:pharmacology*
D017646:Organosilicon Compounds; D012459:Salicylates; C039272:conjonctyl; D005688:Galactosamine