[Hematologic changes in alimentary Pb deficiency in growing rats].
The effect of an alimentary Pb-deficiency on hematological parameters was examined in two growth- and one generation-experiments with female Sprague Dawley rats. The animals were fed a semisynthetic casein-based diet supplemented with 0 ppb up to 800 ppb Pb as Pb-II-acetate-3-hydrate. In two experiments the blood parameters of the rats of G0-generation fed the diet poor in Pb were changed to a normocytic, normochrome pancytopenia at day 21 resp. 28 of the experiments. At day 28 resp. 41 the blood parameters normalized resp. the different Pb-supply in the diet only effected the mean corpuscular volume- and mean corpuscular hemoglobin-values. It was assumed that the disturbances in blood parameters at deficient Pb-supply are caused by temporary hemolysis.
Eberle
J
J
Institut für Ernährungsphysiologie, Technischen Universität München-Wethenstephan, Freising.
Reichlmayr-Lais
A M
AM
Kirchgessner
M
M
D000818:Animals; D001772:Blood Cell Count; D004032:Diet; D004909:Erythrocyte Indices; D005260:Female; D006400:Hematocrit; D007774:Lactation / Q000097:blood; D007854:Lead / Q000172:deficiency*; D010198:Pancytopenia / Q000209:etiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D007854:Lead