title: Detection of human papillomavirus DNA in squamous cell carcinomas of a patient with mycosis fungoides: report of a case.
abstract: Human papillomaviruses (HPV) have been associated with squamous cell carcinomas (SCC) of the skin in both the immunocompetent and the immunocompromised individual. A paucity of literature, however, exists concerning the presence of HPV in SCCs from patients with mycosis fungoides (MF)-[cutaneous T-cell lymphoma (CTCL.)]. We describe a case of multiple SCCs in which HPV DNA was detected over a 9-year period from a patient with MF. This patient with a long history of MF developed 7 small red scaly indurated lesions of sun and non-sun-exposed areas during a 9-year period (1981-1989). Histologic examination of all the lesions revealed that they were SCCs. The patient had no recorded history of arsenic exposure. To investigate the possible role of HPV as a co-carcinogen, we tested the 7 cases of SCC for HPV. Polymerase chain reaction (PCR) was performed on formalin-fixed tissue sections using HPV L.1 consensus sequence primers. Four of the 7 SCCs were positive for HPV DNA. These results suggest a possible role for HPV as a co-carcinogen in the development of SCCs in this patient.
authors.affiliation: Department of Pathology, University of Colorado Health Sciences Center, Denver 80262-0216, USA.
authors.forename: M O
authors.initials: MO
authors.lastname: Liranzo
authors.forename: L
authors.initials: L
authors.lastname: Golitz
authors.forename: K R
authors.initials: KR
authors.lastname: Shroyer
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006801:Humans; D009182:Mycosis Fungoides / Q000821:virology*; D009378:Neoplasms, Multiple Primary / Q000821:virology; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000235:genetics* / Q000473:pathology; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology / Q000821:virology*; D014412:Tumor Virus Infections / Q000235:genetics* / Q000473:pathology
chemical_list: D004279:DNA, Viral