Genetics of neural development in zebrafish.
Large-scale mutant screens in zebrafish have led to the identification of more than 50 genes affecting various aspects of neural development and function, including neural induction, anteroposterior and dorsoventral regionalization, axon pathfinding, neuronal differentiation and survival, and behavior. Phenotypic analysis of mutants for some of these genes has already uncovered important genetic and cellular interactions during development. Ongoing molecular analyses promise to further elucidate the mechanisms underlying neural development in vertebrates.
Schier
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AF
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, New York 10016, USA. schier@saturn.med.nyu.edu
D000818:Animals; D003001:Cloning, Molecular; D005314:Embryonic and Fetal Development / Q000235:genetics; D005796:Genes; D009154:Mutation; D009420:Nervous System / Q000196:embryology*; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics*