[Development of anti tumor agents targeting angiogenesis].
Aberrant angiogenesis is closely involved in invasion/metastasis as well as enlargement of tumor. One recent highlight is to develop anti angiogenic drugs by targeting tumor angiogenesis. Here we describe how tumor angiogenesis is regulated and also recent topics related to angiogenic drug in clinical trials.
Ono
M
M
Dept. of Biochemistry, Kyushu University School of Medicine.
Kuwano
M
M
D000970:Antineoplastic Agents / Q000494:pharmacology; D002986:Clinical Trials as Topic; D003510:Cyclohexanes; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D006877:Hydroxamic Acids; D016898:Interferon-alpha / Q000494:pharmacology; D018664:Interleukin-12 / Q000494:pharmacology; D009369:Neoplasms / Q000098:blood supply* / Q000473:pathology*; D009389:Neovascularization, Pathologic; D000077609:O-(Chloroacetylcarbamoyl)fumagillol; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000494:pharmacology; D010978:Platelet Factor 4 / Q000494:pharmacology; D011135:Polysaccharides, Bacterial / Q000494:pharmacology; D012717:Sesquiterpenes / Q000494:pharmacology; D013792:Thalidomide / Q000494:pharmacology; D013876:Thiophenes / Q000494:pharmacology; D014227:Triazines / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D003510:Cyclohexanes; D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D016898:Interferon-alpha; D011135:Polysaccharides, Bacterial; D012717:Sesquiterpenes; D013876:Thiophenes; D014227:Triazines; D014230:Triazoles; C032263:streptococcal polysaccharide type III group B; D018664:Interleukin-12; D010978:Platelet Factor 4; D010649:Phenylalanine; D013792:Thalidomide; C062058:carboxyamido-triazole; C080985:batimastat; C100342:marimastat; C041836:irsogladine; D000077609:O-(Chloroacetylcarbamoyl)fumagillol