Randomized blinded study of aprotinin infusion for liver crush injuries in the pig model.
Repeat exploratory laparotomies for intra-abdominal bleeding in patients who sustain severe blunt intra-abdominal trauma are common. Reexploration usually reveals no single site of bleeding and the abdomen is closed with laparotomy pad packing, with a presumed diagnosis of coagulopathy. These postoperative coagulational defects may be the result of dilution, consumption, dysfunction, or acquired defects of either the coagulation, fibrinolytic, or platelet systems. The liver plays a major role in the balance of hemostatic systems, and this balance is disrupted by liver trauma. This study investigates the use of intravenous aprotinin, a naturally occurring serine protease inhibitor, in a pig liver crush model to evaluate its effectiveness in reducing intra-abdominal bleeding in experimentally induced shock and non-shock states.
Thomae
K R
KR
Department of Surgery, University of Mississippi Medical Center, Jackson 39216-4505, USA.
Mason
D L
DL
Rock
W A
WA
D000007:Abdominal Injuries / Q000150:complications*; D000818:Animals; D007611:Aprotinin / Q000008:administration & dosage / Q000627:therapeutic use*; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D006490:Hemostatics / Q000008:administration & dosage / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D008099:Liver / Q000293:injuries*; D015842:Serine Proteinase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D012771:Shock, Hemorrhagic / Q000209:etiology; D013552:Swine; D014949:Wounds, Nonpenetrating / Q000150:complications*
D006490:Hemostatics; D015842:Serine Proteinase Inhibitors; D007611:Aprotinin