The inhibitory action of fatty acids on oral bacteria.
Saturated and unsaturated fatty acids and fatty acid derivatives were examined for their growth-inhibitory effects towards three selected oral bacteria: Porphyromonas gingivalis, Selenomonas artemidis, and Streptococcus sobrinus. Of the 45 compounds surveyed, only one, myristoleic acid, was inhibitory towards S. artemidis at a concentration < 100 micrograms/ml. cis-Hexadecenoic and cis-octadecenoic acids were generally inhibitory towards P. gingivalis and S. sobrinus, but there was no correlation between the position of the double bond and the minimum inhibitory concentration. Supra-minimum inhibitory concentrations of palmitoleic acid did not promote leakage of intracellular materials from either P. gingivalis or S. sobrinus, nor was L-isoleucine uptake by S. sobrinus inhibited. Fatty acids and derivatives were also examined for prospective synergistic or antagonistic interactions with thymol vis-à-vis growth inhibition of the test strains. Lauric acid and myristic acid each behaved synergistically with thymol to inhibit the growth of at least one test strain, whereas cis-10-heptadecenoic acid and thymol were noticeably antagonistic towards the growth of S. sobrinus.
Shapiro
S
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Institut für orale Mikrobiologie und allgemeine Immunologie, Zentrum für Zahn-, Mund- und Kieferheilkunde, Universität Zürich, Switzerland.
D001421:Bacteria, Anaerobic / Q000187:drug effects*; D004357:Drug Synergism; D005227:Fatty Acids / Q000737:chemistry / Q000494:pharmacology*; D005229:Fatty Acids, Monounsaturated / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009227:Myristic Acids / Q000494:pharmacology; D016966:Porphyromonas gingivalis / Q000187:drug effects*; D013291:Streptococcus / Q000187:drug effects; D016986:Streptococcus sobrinus / Q000187:drug effects*; D013943:Thymol / Q000494:pharmacology
D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D009227:Myristic Acids; C008757:palmitoleic acid; D013943:Thymol