title: The effect of long-term calcium supplementation on indices of iron, zinc and magnesium status in lactating Gambian women.
abstract: The effect of long-term supplementation with CaCO3 on indices of Fe, Zn and Mg status was investigated in a randomized, double-blind intervention study of sixty lactating Gambian women. The supplement contained 1000 mg Ca and was consumed between meals 5 d/week, for 1 year starting 1.5 weeks postpartum. Compliance was 100%. Plasma ferritin concentration, plasma Zn concentration and urinary Mg output were measured before, during and after supplementation at 1.5, 13, 52 and 78 weeks postpartum. No significant differences in mineral status were observed at any time between women in the supplement and placebo groups. Analysis of the longitudinal data series showed that plasma ferritin and Mg excretion were characteristic of the individual (P < 0.001). Within individuals, ferritin concentration was higher at 1.5 weeks postpartum than later in lactation (P = 0.002). Plasma Zn concentration was lower at 1.5 weeks postpartum than at other times (P < 0.001), an effect which disappeared after albumin correction. Low plasma concentrations of ferritin and Zn indicated that the Gambian women were at high risk of Fe and Zn deficiency. Measurements of alpha 1-antichymotrypsin suggested that the results were not confounded by acute-phase responses. The results of the present study indicate that 1000 mg Ca as CaCO3 given between meals does not deleteriously affect plasma ferritin and Zn concentrations or urinary Mg excretion in women who are at risk of Fe and Zn deficiency.
authors.affiliation: Medical Research Council Dunn Nutrition Unit, Cambridge, The Gambia.
authors.forename: L
authors.initials: L
authors.lastname: Yan
authors.forename: A
authors.initials: A
authors.lastname: Prentice
authors.forename: B
authors.initials: B
authors.lastname: Dibba
authors.forename: L M
authors.initials: LM
authors.lastname: Jarjou
authors.forename: D M
authors.initials: DM
authors.lastname: Stirling
authors.forename: S
authors.initials: S
authors.lastname: Fairweather-Tait
mesh_terms: D000293:Adolescent; D000328:Adult; D002118:Calcium / Q000008:administration & dosage*; D004311:Double-Blind Method; D004739:England; D005260:Female; D005293:Ferritins / Q000097:blood; D005527:Food, Fortified; D005714:Gambia; D006801:Humans; D007774:Lactation / Q000378:metabolism*; D008274:Magnesium / Q000652:urine; D008670:Metals / Q000378:metabolism*; D009752:Nutritional Status; D015032:Zinc / Q000097:blood
chemical_list: D008670:Metals; D005293:Ferritins; D008274:Magnesium; D015032:Zinc; D002118:Calcium