[The role of magnetic resonance spectroscopic imaging in patients with Parkinson's disease].
There are some single voxel proton magnetic resonance spectroscopy(MRS) of Parkinson's disease but no multi-voxel proton MRS. Proton magnetic resonance spectroscopic imaging(MRSI) is the multi-voxel method, from which we can obtain many spectra from many voxel at the same time. The distribution of each metabolite can be observed in the metabolite map. Although defects in oxidative phosphorylation have been reported from the studies of Parkinson's disease and dopaminergic cell death has been observed, the cause of Parkinson's disease is unknown. The spectra from the striatum and surroundings and the metabolite maps in MRSI will help to understand the pathogenesis of the disease.
Naruse
S
S
Department of Radiology, Kyoto Prefectural University of Medicine.
Kizu
O
O
Furuya
S
S
D001921:Brain / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010085:Oxidative Phosphorylation; D010300:Parkinson Disease / Q000175:diagnosis*; D011522:Protons
D011522:Protons