Identification of nucleotide sequences that regulate transcription of the MCF13 murine leukemia virus long terminal repeat in activated T cells.
The region downstream of the enhancer (DEN) of the long terminal repeat of the mink cell focus-forming murine leukemia virus is important for viral pathogenicity. Another important activity of DEN is its control of transcription in activated T cells, and we have determined that an NF-kappaB site is critical for this activity.
Yoshimura
F K
FK
Department of Immunology and Microbiology, Wayne State University, Detroit, Michigan 48201, USA. fyoshi@med.wayne.edu
Cankovic
M
M
Smeltz
R
R
Ibrahim
S
S
D000818:Animals; D015967:Gene Expression Regulation, Viral; D006801:Humans; D015759:Ionomycin / Q000494:pharmacology; D019169:Jurkat Cells; D008213:Lymphocyte Activation; D008908:Mink Cell Focus-Inducing Viruses / Q000235:genetics* / Q000472:pathogenicity; D016296:Mutagenesis; D016328:NF-kappa B / Q000378:metabolism; D012045:Regulatory Sequences, Nucleic Acid; D012091:Repetitive Sequences, Nucleic Acid; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014158:Transcription, Genetic
D016328:NF-kappa B; D015759:Ionomycin; D013755:Tetradecanoylphorbol Acetate