title: [Treatment of mild and moderate hypertension with diltiazem 240mg. Brazilian multicenter trial].
abstract: OBJECTIVE
  The efficacy and safety of diltiazen 240mg was evaluated in essential hypertensive patients with diastolic pressure in the range of 95 to 115 mmHg.
  
  
  METHODS
  In an open, non-comparative multicenter trial 2.165 hypertensives had the supine and orthostatic arterial blood pressure measured before, after 14 days with non pharmacologic therapy and after 40 days taking diltiazen 240mg/day. Also, the serum levels of lipids, glucose and electrolytes were measured before and after the use of the active drug.
  
  
  RESULTS
  The systolic arterial pressure in the first day was 166 +/- 18mmHg, in the 14th day was 155 +/- 20mmHg; and, in the 54th day was 141 +/- 14mmHg (p < 0.05). Also, supine and orthostatic diastolic blood pressure was lower in the 14th and in the 54th days when compared to baseline (p < 0.05). Cholesterol, triglycerides, urea and uric acid levels decreased significantly (p < 0.05) during treatment.
  
  
  CONCLUSIONS
  This study demonstrates that diltiazem 240mg/day for the treatment of hypertension is well tolerated, efficient and shows no metabolic undesirable effects.
authors.affiliation: Unidade de Hipertensão Arterial do Hospital das Clinicas, Disciplina de Nefrologia da Faculdade de Medicina da USP.
authors.forename: J L
authors.initials: JL
authors.lastname: Santello
authors.forename: K C
authors.initials: KC
authors.lastname: Ortega
authors.forename: D
authors.initials: D
authors.lastname: Mion Júnior
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001794:Blood Pressure / Q000187:drug effects; D004110:Diltiazem / Q000627:therapeutic use*; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D004110:Diltiazem