A 3D- and 4D-ESR imaging system for small animals.
A new version of in vivo ESR-CT system composed of custom-made 0.7 GHz ESR spectrometer, air-core magnet with a field-scanning coil, three field-gradient coils, and two computers enables up- and down-field, and rapid magnetic-field scanning linearly controlled by computer. 3D-pictures of distribution of nitroxide radicals injected in brains and livers of rats and mice were obtained in 1.5 min with resolution of 1 mm. We have also succeeded in obtaining spatial-time imagings of the animals.
Oikawa
K
K
Yamagata Research Institute of Technology, Japan.
Ogata
T
T
Togashi
H
H
Yokoyama
H
H
Ohya-Nishiguchi
H
H
Kamada
H
H
D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism; D003497:Cyclic N-Oxides; D004578:Electron Spin Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D005609:Free Radicals / Q000032:analysis / Q000493:pharmacokinetics; D008099:Liver / Q000033:anatomy & histology / Q000378:metabolism; D008297:Male; D051379:Mice; D009589:Nitrogen Oxides / Q000032:analysis / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D013113:Spin Labels; D014054:Tomography / Q000295:instrumentation / Q000379:methods*
D003497:Cyclic N-Oxides; D005609:Free Radicals; D009589:Nitrogen Oxides; D013113:Spin Labels; C039900:nitroxyl; C001803:tempol