title: Morphological and biomechanical difference in healing in segmental tibial defects implanted with Biocoral or tricalcium phosphate cylinders.
abstract: To evaluate the effects of two bioceramics on bone regeneration during repair of segmental bone defects, Biocoral and tricalcium phosphate cylinders were implanted in osteotomized sheep tibial defects 16 mm in length and followed up for 16 weeks. In comparison with the TCP-implanted defect, a significant increment in area and density of external callus was quantified radiomorphometrically at 3 weeks, and a marked increase in maximal torque capacity, maximal angle of deformation and absorption of energy was demonstrated mechanically in the Biocoral-implanted tibia at 16 weeks after implantation. Better bone integration with the substratum was microscopically observed in Biocoral cylinders. With good osteointegration and biomechanical-performance, Biocoral seems to be superior to TCP in repair of segmental defects in weight-bearing limbs.
authors.affiliation: Institute of Medical Technology, University of Tampere, Finland.
authors.forename: T J
authors.initials: TJ
authors.lastname: Gao
authors.forename: T K
authors.initials: TK
authors.lastname: Tuominen
authors.forename: T S
authors.initials: TS
authors.lastname: Lindholm
authors.forename: B
authors.initials: B
authors.lastname: Kommonen
authors.forename: T C
authors.initials: TC
authors.lastname: Lindholm
mesh_terms: D000818:Animals; D018786:Bone Substitutes; D002130:Calcium Phosphates; D002516:Ceramics; D005260:Female; D017102:Fracture Healing; D008855:Microscopy, Electron, Scanning; D019736:Prostheses and Implants; D011859:Radiography; D012756:Sheep; D013978:Tibial Fractures / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D019415:Torque
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous