Catastrophic antiphospholipid antibody syndrome in pediatric systemic lupus erythematosus.
Catastrophic antiphospholipid antibody syndrome, reported in a minority of patients with circulating antiphospholipid antibodies, is characterized by widespread vascular occlusions. The term "catastrophic" has been used to describe the severity of symptomatology, sometimes leading to death. We describe a girl aged 11 years, fulfilling diagnostic criteria for systemic lupus erythematosus, with recurrent episodes of thromboembolic phenomena involving lung and skin, complicated with disseminated intravascular coagulation. Treatment with warfarin ultimately resulted in effective control of the disease.
Falcini
F
F
Department of Pediatrics-Rheumatology Unit, Meyer Hospital, University of Florence, Italy.
Taccetti
G
G
Ermini
M
M
Trapani
S
S
Matucci Cerinic
M
M
D000925:Anticoagulants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D002648:Child; D004211:Disseminated Intravascular Coagulation / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D005385:Fingers / Q000473:pathology; D006801:Humans; D007511:Ischemia; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D014859:Warfarin / Q000627:therapeutic use*
D000925:Anticoagulants; D014859:Warfarin