Cardiopulmonary bypass causes release of leukocyte proteinase-3.
Activation of leukocytes is an important but not fully understood event during cardiopulmonary bypass. Leukocyte proteinase-3, also known as neutrophil proteinase-4, was analysed in plasma by means of an enzyme-linked immunosorbent assay after heart surgery with extracorporeal circulation. The levels of proteinase-3 increased ninefold after surgery compared with preoperative values. Over the following days, the levels declined but were still elevated on the second postoperative day. The levels of proteinase-3 3 h after heart surgery were correlated to the time on cardiopulmonary bypass. Proteinase-3 is involved in the inflammatory process seen after extracorporeal circulation.
Jönsson
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Department of Thoracic Surgery, Lund University, Sweden.
D000328:Adult; D000368:Aged; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053146:Myeloblastin; D018375:Neutrophil Activation; D012697:Serine Endopeptidases / Q000097:blood*; D012709:Serum Albumin / Q000737:chemistry; D013997:Time Factors; D000515:alpha 1-Antitrypsin / Q000737:chemistry; D000511:alpha-Macroglobulins / Q000737:chemistry
D012709:Serum Albumin; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D012697:Serine Endopeptidases; D053146:Myeloblastin