Dopamine agonist amineptine prevents the antidepressant effect of sleep deprivation.
In a double-blind study, the effects of the interaction between the administration of amineptine versus placebo and repeated cycles of total sleep deprivation (TSD), which is thought to act through an enhancement in dopaminergic transmission, were analyzed. Twenty-two consecutively admitted patients with bipolar depression formed the study group. Repeated administrations of TSD significantly enhanced perceived mood levels in placebo-treated patients, while amineptine administration blocked the antidepressant action of TSD. Hypothesized changes in brain dopaminergic transmission attributable to amineptine pretreatment are discussed.
Benedetti
F
F
Istituto Scientifico Ospedale San Raffaele, IRCCS Department of Neuropsychiatric Sciences, University of Milan School of Medicine, Italy.
Barbini
B
B
Campori
E
E
Colombo
C
C
Smeraldi
E
E
D000328:Adult; D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001714:Bipolar Disorder / Q000503:physiopathology* / Q000523:psychology; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D003866:Depressive Disorder / Q000503:physiopathology* / Q000523:psychology; D003986:Dibenzocycloheptenes / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology*; D018491:Dopamine Agonists / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012892:Sleep Deprivation / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
D000929:Antidepressive Agents, Tricyclic; D003986:Dibenzocycloheptenes; D018491:Dopamine Agonists; C011597:amineptin; D004298:Dopamine