Blockade of K(ATP) channels with glibenclamide does not abolish preconditioning during demand ischemia.
The role of adenosine triphosphate-sensitive potassium channels in the adaptive response to demand ischemia was tested in 22 patients treated with placebo or glibenclamide before sequential exercise testing or atrial pacing. Glibenclamide did not affect the improvement in signs of ischemia in both protocols, indicating that opening of these channels is not a mechanism of this adaptive response in humans.
Correa
S D
SD
Department of Internal Medicine, University of California, Davis 95616, USA.
Schaefer
S
S
D000222:Adaptation, Physiological; D000255:Adenosine Triphosphate / Q000494:pharmacology; D000368:Aged; D002304:Cardiac Pacing, Artificial; D004311:Double-Blind Method; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D005905:Glyburide / Q000494:pharmacology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000503:physiopathology*; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology*
D007004:Hypoglycemic Agents; D015221:Potassium Channels; D000255:Adenosine Triphosphate; D005905:Glyburide