[The mutagenic action of gamma radiation on Chinese hamster cells. The cytogenetic characteristics of the mutants at the HPRT locus].
The peculiarities of mutation induction and cytogenetic characteristics of spontaneous and radiation-induced HPRT mutant clones have been studied. The linear-quadratic dependence of the mutation induction on radiation dose has been found. High heterogeneity of cytogenetic parameters (aneuploidy and chromosome aberration frequency) has been shown in the mutants.
Govorun
R D
RD
Koshlan'
I V
IV
Krasavin
E A
EA
Shmakova
N L
NL
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000235:genetics*; D006224:Cricetinae; D003412:Cricetulus; D004307:Dose-Response Relationship, Radiation; D004351:Drug Resistance; D005720:Gamma Rays; D005796:Genes / Q000528:radiation effects*; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics / Q000528:radiation effects*; D016296:Mutagenesis; D013866:Thioguanine / Q000037:antagonists & inhibitors
D007041:Hypoxanthine Phosphoribosyltransferase; D013866:Thioguanine