title: Body fat distribution before and after weight gain in anorexia nervosa.
abstract: OBJECTIVE
  To study abdominal fat distribution in anorexia nervosa subjects and to assess the effects of initial weight regain on abdominal fat distribution.
  
  
  METHODS
  Longitudinal, clinical study. The baseline measurement was acquired within four days of admission to the eating disorders clinic. All patients were treated by re-feeding, reinforced by psychotherapy. Following weight regain of at least 5 kg, a second body fat distribution evaluation was performed. Of the 21 subjects evaluated at baseline, 14 achieved the goal of body weight regain and were retested.
  
  
  METHODS
  Fourteen subjects (age: 18-38 y; body mass index: 11.5-18.3; relative body weight: 54.9-88.3%).
  
  
  METHODS
  Total, subcutaneous and visceral abdominal adipose tissue areas at the L4-L5 level were evaluated by computed tomography.
  
  
  RESULTS
  At baseline the subjects showed a higher proportion of visceral adipose tissue (% visceral adipose tissue = 55.3 +/- 26.1). A significant association was observed between body weight and both subcutaneous adipose tissue and total adipose tissue. A regain of body weight of 7.3 +/- 1.6 kg was accompanied by a significant increase in total adipose tissue, comprising both subcutaneous and visceral adipose tissue. The increase observed in subcutaneous adipose tissue, however, was significantly greater than for visceral adipose tissue (212.6% vs 116.8%, respectively, P < 0.01).
  
  
  CONCLUSIONS
  The results of the current study show a higher proportion of visceral adipose tissue than subcutaneous adipose tissue in anorexia nervosa subjects. With regain of body weight there is a preferential regain of subcutaneous adipose tissue. These data demonstrate a redistribution of abdominal adipose tissue with weight regain in anorexia nervosa subjects.
authors.affiliation: Institute of Internal Medicine, University of Verona, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Zamboni
authors.forename: F
authors.initials: F
authors.lastname: Armellini
authors.forename: E
authors.initials: E
authors.lastname: Turcato
authors.forename: P
authors.initials: P
authors.lastname: Todisco
authors.forename: D
authors.initials: D
authors.lastname: Gallagher
authors.forename: R
authors.initials: R
authors.lastname: Dalle Grave
authors.forename: S
authors.initials: S
authors.lastname: Heymsfield
authors.forename: O
authors.initials: O
authors.lastname: Bosello
mesh_terms: D000005:Abdomen / Q000502:physiology; D000273:Adipose Tissue / Q000033:anatomy & histology; D000328:Adult; D000856:Anorexia Nervosa / Q000503:physiopathology*; D001823:Body Composition; D001824:Body Constitution; D005260:Female; D006801:Humans; D011860:Radiography, Abdominal; D015898:Tomography Scanners, X-Ray Computed; D015430:Weight Gain / Q000502:physiology*