title: Basophil count in neonates is not suitable for atopy predictivity.
abstract: Basophil granulocytes and their mediators are involved in the pathogenesis of allergic inflammation. We evaluated basophil count, blood histamine content, eosinophil count and serum total IgE levels in one hundred-thirteen healthy newborns at birth. 102 children were prospectively studied with a follow up to 18 months of age for development of atopic disorders. No difference was found in newborns with biparental family history of atopy (FHA) in comparison with newborns with monoparental FHA and with newborns without FHA. Children who developed atopic disorders had neonatal basophil counts higher than those who did not develop atopic symptoms (p = 0.03). No significant correlation was found between basophil and eosinophil counts (rs = 0.013), between basophil count and serum total IgE levels (rs = 0.012) and between basophil count and blood histamine content. Positive predictive value and sensitivity of basophil count for allergy up to 18 months of age was only 33% and 27%, respectively. Our data indicate that an increased basophil count at birth is not associated with FHA and is not a good predictive marker of atopy.
authors.affiliation: Department of Pediatrics, Villa Bianca Hospital, Naples, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Calbi
authors.forename: L
authors.initials: L
authors.lastname: Giacchetti
authors.forename: A
authors.initials: A
authors.lastname: Coppola
authors.forename: M
authors.initials: M
authors.lastname: Triggiani
mesh_terms: D001491:Basophils; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000097:blood* / Q000175:diagnosis*; D007231:Infant, Newborn; D007958:Leukocyte Count; D011237:Predictive Value of Tests