Methionine and cysteine metabolism in Fasciola hepatica.
Radiolabel from the methyl groups of serine and methyltetrahydrofolate was readily incorporated into methionine in adult Fasciola hepatica, and a substantial proportion of the label from [35S]methionine appeared in cysteine. The data suggest that methionine synthesis is via methyltetrahydrofolate-homocysteine methyltransferase and that there is cysteine synthesis from methionine. Cystathionine-beta-synthase and gamma-cystathionase activities were demonstrated in homogenates.
Bankov
I
I
Institute of Experimental Pathology and Parasitology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Timanova
A
A
Barrett
J
J
D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000378:metabolism; D000003:Abattoirs; D000818:Animals; D003541:Cystathionine beta-Synthase / Q000378:metabolism; D003542:Cystathionine gamma-Lyase / Q000378:metabolism; D003545:Cysteine / Q000378:metabolism*; D005210:Fasciola hepatica / Q000378:metabolism*; D050904:Homocysteine S-Methyltransferase; D008715:Methionine / Q000378:metabolism*; D008780:Methyltransferases / Q000378:metabolism; D011865:Radioisotope Dilution Technique; D012694:Serine / Q000378:metabolism; D013462:Sulfur Radioisotopes
D013462:Sulfur Radioisotopes; D012694:Serine; D008715:Methionine; D008780:Methyltransferases; D050904:Homocysteine S-Methyltransferase; D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; D003541:Cystathionine beta-Synthase; D003542:Cystathionine gamma-Lyase; D003545:Cysteine