Experimental electroretinographic exploration of retinal ischemia: preventive use of free radical scavengers and anti-PAF agents.
Electroretinographic exploration is an effective approach to evaluate retinal function. In order to investigate physiopathological mechanisms and evaluate potentially protective therapies for retinal ischemia, we developed three experimental models: the first two on isolated retina, with ischemia induced by either stopping perfusion or clamping the ophthalmic artery, and the third, in vivo, with ischemia induced by ocular hypertonia. Since free radicals are implicated in the formation of post-ischemic lesions, we evaluated the protective effects of drugs known to be free radical scavengers and of an immunomediator antagonist, an anti-PAF (platelet activating factor) agent.
Menerath
J M
JM
Facultés de Médecine et de Pharmacie, INSERM U.71. Clermont-Ferrand, France.
Cluzel
J
J
Droy-Lefaix
M T
MT
Doly
M
M
D000704:Analysis of Variance; D000818:Animals; D001381:Azepines / Q000494:pharmacology*; D003623:Dark Adaptation; D004195:Disease Models, Animal; D004596:Electroretinography; D016166:Free Radical Scavengers / Q000494:pharmacology*; D020441:Ginkgo biloba; D007511:Ischemia / Q000188:drug therapy / Q000503:physiopathology*; D010936:Plant Extracts / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012164:Retinal Diseases / Q000188:drug therapy / Q000503:physiopathology; D058924:Thienopyridines; D014230:Triazoles / Q000494:pharmacology*; D000096983:Ginkgo Extract
D001381:Azepines; D016166:Free Radical Scavengers; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D058924:Thienopyridines; D014230:Triazoles; C066686:BN 50730; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract