title: Time-dependent influence of the somatostatin analogue octreotide on the proliferation of rat astrocytes and glioma cells.
abstract: The somatostatin receptor subtype sst2 was visualized by immunostaining on cultivated rat astrocytes and C6 rat glioma cells. Octreotide, a metabolically stable sst2 agonist reduced [3H]thymidine incorporation into DNA of both cell types dose-dependently only after short-time application (2-5 h), after prolonged incubation (> 12 h) no antiproliferative effect was measurable. We conclude that sst2 receptors may be desensitized. Thus, desensitization might hinder application of octreotide to reduce glial tumour growth.
authors.affiliation: Anatomisches Institut, Universität zu Kiel, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Feindt
authors.forename: R
authors.initials: R
authors.lastname: Mentlein
authors.forename: B
authors.initials: B
authors.lastname: Krisch
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001253:Astrocytes / Q000166:cytology* / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D005910:Glioma; D006728:Hormones / Q000494:pharmacology*; D007150:Immunohistochemistry; D008969:Molecular Sequence Data; D015282:Octreotide / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000031:analogs & derivatives; D013997:Time Factors; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000187:drug effects
chemical_list: D006728:Hormones; D013004:Somatostatin; D015282:Octreotide