Blood lipid changes in repeated infections of vivax malaria.
Alterations in the levels of plasma and erythrocyte membrane lipids in fresh and repeated P. vivax malarial patients were studied. A significant fall in plasma cholesterol and phospholipids was observed in repeated malaria. The decrease was highly significant when the number of attacks were more than five (p < 0.0001). A significant increase in plasma triglycerides and non-esterified fatty acids were observed when the number of attacks was between 4-5 (p < 0.0001). Erythrocyte membrane cholesterol and phospholipids were increased in repeated malaria. The increase in erythrocyte membrane cholesterol and phospholipids, was significant in more than five attacks (p < 0.0001). The activities of LCAT and LPL were decreased significantly in repeated malaria, when the number of attacks were between 4-5 (p < 0.0001). It is suggested that repeated malarial attack alters the lipid metabolism and the changes are marked with increase in the number of malarial attacks.
Sumitha
K
K
Department of Medical Biochemistry, Dr. A.L.M. Postgraduate Institute of Basic Medical Sciences, University of Madras, Taramani, India.
Ravichandiran
K
K
Selvam
R
R
D000293:Adolescent; D000328:Adult; D002784:Cholesterol / Q000032:analysis; D004912:Erythrocytes / Q000737:chemistry; D005227:Fatty Acids / Q000032:analysis; D006801:Humans; D016780:Malaria, Vivax / Q000097:blood* / Q000150:complications; D008563:Membrane Lipids / Q000032:analysis; D010743:Phospholipids / Q000032:analysis; D012008:Recurrence; D014280:Triglycerides / Q000032:analysis
D005227:Fatty Acids; D008563:Membrane Lipids; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol