title: Meningeal carcinomatosis as the presenting manifestation of gastric adenocarcinoma.
abstract: Leptomeningeal involvement is usually reported as a secondary event in advanced, already diagnosed, gastric adenocarcinoma. We report a case of leptomeningeal carcinomatosis in which identification of mucus-secreting "signet-ring" carcinoma cells in the cerebrospinal fluid allowed the diagnosis of an otherwise asymptomatic gastric cancer. This is one of the very few reported cases manifesting as such in the medical literature.
authors.affiliation: Department of Internal Medicine, American University of Beirut-Medical Center, Lebanon.
authors.forename: L S
authors.initials: LS
authors.lastname: Deeb
authors.forename: B I
authors.initials: BI
authors.lastname: Yamout
authors.forename: A I
authors.initials: AI
authors.lastname: Shamseddine
authors.forename: N S
authors.initials: NS
authors.lastname: Shabb
authors.forename: S M
authors.initials: SM
authors.lastname: Uthman
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000188:drug therapy; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018279:Carcinoma, Signet Ring Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000556:secondary; D004317:Doxorubicin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000556:secondary; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000964:Antimetabolites, Antineoplastic; D004317:Doxorubicin; D005472:Fluorouracil; D008727:Methotrexate