title: Cortical and subcortical T2 shortening in multiple sclerosis.
abstract: Low signal intensity on long-repetition-time MR sequences has been observed in deep gray matter structures in patients with multiple sclerosis. This T2 shortening most likely represents a nonspecific degenerative process. We recently observed T2 shortening in the pericentral cortical gray matter and subcortical white matter in a patient with severe multiple sclerosis and we postulate that this represents an additional manifestation of neural degeneration.
authors.affiliation: Department of Radiology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA.
authors.forename: C
authors.initials: C
authors.lastname: Russo
authors.forename: W R
authors.initials: WR
authors.lastname: Smoker
authors.forename: W
authors.initials: W
authors.lastname: Kubal
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D007501:Iron / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000175:diagnosis*; D009410:Nerve Degeneration / Q000502:physiology; D009460:Neurologic Examination
chemical_list: D007501:Iron