title: [Inflammatory diseases of the spinal cord and spinal nerve roots in the MRI].
abstract: OBJECTIVE
  To evaluate characteristic and reliable MRI patterns of different inflammatory lesions of the spinal cord and the nerve roots in immunologically compromised and immunologically competent patients in order to be able to establish a correct diagnosis based on MRI findings.
  
  
  METHODS
  The MRI examinations of 52 patients (27 men, 25 women, mean age 38.5 years, range 14-75 years) with proven inflammatory lesions (39 patients) or tumorous/postactinic lesions of the spinal cord (6 patients) and vascular malformations of the spinal cord (7 patients) were retrospectively analyzed. All examinations were performed on a 1.5 T MR unit, using bi- or triplanar T1-w pre- and postcontrast as well as T2-w SE sequences. Additionally, a review of the common medical literature concerning inflammatory lesions of the spinal cord was included.
  
  
  RESULTS
  Clinical and radiological examinations allow a subdivision of inflammations of the spinal cord and the nerve roots into (meningoradiculo) myelitis and meningoradiculo (myelitis) in immunologically suppressed or competent patients. The MRI patterns of these two inflammatory subtypes vary: meningoradiculitis presents with an enhancement of the nerve roots and the leptomeninges; myelitis itself is characterized by single or multiple, diffuse or multifocal, with or without nodular, patchy or diffusely enhancing intramedullary lesions, with or without thickening of the cord and leptomeningeal inflammation. This differentiation helps to determine the underlying etiology in some of the patients. The immunologically suppressed patient suffers from viral infections (especially herpes simplex, varicella-zoster virus, cytomegalovirus), bacterinal infections (tuberculosis), but rarely from parasitic infections. The immunologically competent patient suffers from bacterial (borreliosis), but rarely viral infections, sarcoidosis and demyelinating diseases. Idiopathic myelitis is also common.
  
  
  CONCLUSIONS
  Secondary ischemic and demyelinating processes result in a complex morphology of inflammatory lesions on MRI, and therefore the whole spectrum of demyelinating, ischemic and inflammatory lesions has to be included in the differential diagnosis. Even tumors may imitate inflammatory myelitis and radiculitis. Most commonly, meningoradiculitis can be separated from myelitis. A reliable diagnosis of a specific inflammatory lesion is difficult and is mostly achieved in patients with multiple sclerosis and in patients with HIV-associated cytomegalovirus infection.
authors.affiliation: Institut für Neuroradiologie, Universitätsspital Zürich.
authors.forename: S
authors.initials: S
authors.lastname: Sartoretti-Schefer
authors.forename: W
authors.initials: W
authors.lastname: Wichmann
authors.forename: A
authors.initials: A
authors.lastname: Valavanis
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000209:etiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008581:Meningitis / Q000175:diagnosis / Q000209:etiology; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000209:etiology; D009187:Myelitis / Q000175:diagnosis* / Q000209:etiology; D009188:Myelitis, Transverse / Q000175:diagnosis / Q000209:etiology; D011843:Radiculopathy / Q000175:diagnosis* / Q000209:etiology; D012507:Sarcoidosis / Q000175:diagnosis / Q000209:etiology; D013116:Spinal Cord / Q000473:pathology*; D013126:Spinal Nerve Roots / Q000473:pathology*