title: Evaluation of recombinant allergens Bet v 1 and Bet v 2 (profilin) by Pharmacia CAP system in patients with pollen-related allergy to birch and apple.
abstract: Sixty-five patients presenting either rhinoconjunctivitis or asthma and sensitized to pollens of trees of the order Fagales were studied by the Pharmacia CAP system in order to assess specific IgE for the important birch pollen allergens Bet v 1 and Bet v 2. All 65 subjects reacted to at least one of the recombinant birch allergens: 43% to Bet v 1, 30.7% to Bet v 2, and 26% to both. Patients monosensitized to birch did not react to Bet v 2. Of patients with a history of oral allergy syndrome after eating apples, 16/28 (57%) reacted to Bet v 1; among 20 polysensitized subjects presenting oral allergy syndrome after consumption of apple, four reacted to Bet v 2 (20%). Among patients with IgE against both recombinant allergens, six (35.30%) presented symptoms of allergy after eating apples. Our results indicate that sensitization to Bet v 1 is specific for birch and apple allergies, whereas sensitization to Bet v 2 is common in polysensitized patients.
authors.affiliation: Allergy Unit, S.S. Trinità Hospital, Fossano, Italy.
authors.forename: R E
authors.initials: RE
authors.lastname: Rossi
authors.forename: G
authors.initials: G
authors.lastname: Monasterolo
authors.forename: D
authors.initials: D
authors.lastname: Operti
authors.forename: M
authors.initials: M
authors.lastname: Corsi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000485:Allergens / Q000276:immunology*; D052179:Antigens, Plant; D001249:Asthma / Q000276:immunology; D002648:Child; D003285:Contractile Proteins; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005512:Food Hypersensitivity / Q000276:immunology; D005638:Fruit / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007428:Intradermal Tests / Q000379:methods; D008297:Male; D008840:Microfilament Proteins / Q000276:immunology*; D008875:Middle Aged; D010940:Plant Proteins / Q000276:immunology*; D011058:Pollen / Q000276:immunology*; D051304:Profilins; D011852:Radioallergosorbent Test; D011933:Reagent Kits, Diagnostic; D011994:Recombinant Proteins / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology
chemical_list: D000485:Allergens; D052179:Antigens, Plant; D003285:Contractile Proteins; D008840:Microfilament Proteins; D010940:Plant Proteins; D051304:Profilins; D011933:Reagent Kits, Diagnostic; D011994:Recombinant Proteins; C061312:Bet v 1 allergen, Betula; D007073:Immunoglobulin E