title: Prediction of results following Gamma Knife surgery for brain stem and other centrally located arteriovenous malformations: relation to natural course.
abstract: Two models for predicting the results of Gamma Knife surgery for brain stem and other centrally located arteriovenous malformations (AVMs) are presented. By using these models, the probability of total obliteration and the risk of complications can be predicted. The model to predict the probability for obliteration is based on the following two observations. First, there is a positive relationship between the minimum dose given to the AVM nidus and the incidence of obliteration. Second, there is a negative relationship between the AVM nidus volume and the minimum dose given in the obliterated cases. The risk estimation model is also based on two observations. First, centrally located AVMs carry a higher risk of complications than those located peripherally. Second, the average dose to volumes which are large for radiosurgery is related to the incidence of complications. The findings of this study may be used to estimate the consequences of Gamma Knife treatment for every individual case prior to the treatment. This makes a comparison between different treatment options and no treatment possible. The risk of hemorrhage without any treatment is also quantified.
authors.affiliation: Department of Neurosurgery, Karolinska Hospital, Stockholm, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Karlsson
authors.forename: I
authors.initials: I
authors.lastname: Lax
authors.forename: M
authors.initials: M
authors.lastname: Söderman
authors.forename: L
authors.initials: L
authors.lastname: Kihlström
authors.forename: C
authors.initials: C
authors.lastname: Lindquist
mesh_terms: D000293:Adolescent; D001933:Brain Stem / Q000098:blood supply / Q000601:surgery*; D002543:Cerebral Hemorrhage / Q000209:etiology; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D016014:Linear Models; D008297:Male; D011336:Probability; D011379:Prognosis; D016634:Radiosurgery / Q000009:adverse effects*; D012307:Risk Factors