Status of free radicals and their scavenging enzymes in pregnancy induced hypertension (PIH).
The levels of lipid peroxidation (malonaldialdehyde), one of the consequence of free radical damage, and the antioxidant enzymes superoxide dismutase and catalase were estimated in the blood samples of fourteen normal and thirteen pregnancy induced hypertensive patients. A marked increase in malonaldialdehyde (p < 0.001) with concomitant decrease in superoxide dismutase (p < 0.001), catalase (p < 0.001) activities were observed in PIH as compared to normal pregnancy, thereby indicating the involvement of free radicals in PIH.
Pandey
S
S
Department of Pharmacology & Therapeutics, King George's Medical College, Lucknow, India.
Gujrati
V R
VR
Chandravati
Sanger
K C
KC
Shanker
K
K
D000328:Adult; D002374:Catalase / Q000097:blood; D005260:Female; D016166:Free Radical Scavengers / Q000378:metabolism*; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000209:etiology / Q000378:metabolism*; D008315:Malondialdehyde / Q000097:blood; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000201:enzymology / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000097:blood
D016166:Free Radical Scavengers; D005609:Free Radicals; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase