TMC-1 A, B, C and D, new antibiotics of the manumycin group produced by Streptomyces sp. Taxonomy, production, isolation, physico-chemical properties, structure elucidation and biological properties.
Four new antitumor antibiotics, TMC-1 A, B, C and D were isolated from a fermentation broth of Streptomyces sp. A-230. Spectroscopic studies have shown that TMC-1 A to D were new members of the manumycin class of antibiotics. These antibiotics showed cytotoxic activities against various tumor cell lines in vitro.
Kohno
J
J
Lead Generation Research Laboratory at Toda, Japan.
Nishio
M
M
Kawano
K
K
Nakanishi
N
N
Suzuki
S
S
Uchida
T
T
Komatsubara
S
S
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D003470:Culture Media; D003512:Cyclohexanones / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D053284:Polyunsaturated Alkamides; D013302:Streptomyces / Q000145:classification / Q000302:isolation & purification / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D000903:Antibiotics, Antineoplastic; D003470:Culture Media; D003512:Cyclohexanones; D011090:Polyenes; D053284:Polyunsaturated Alkamides; C104488:TMC 1 A; C104489:TMC 1 B; C104490:TMC 1 C; C104491:TMC 1 D; C054474:manumycin