title: Clinical Significance of a cervical cytologic diagnosis of atypical squamous cells of undetermined significance. Favoring a reactive process or low grade squamous intraepithelial lesion.
abstract: OBJECTIVE
  To define the clinical significance of qualifying the cytologic diagnosis of atypical squamous cells of undetermined significance (ASCUS) as favoring either a reactive process or a low grade squamous intraepithelial lesion (LSIL) in an effort to provide management guidelines.
  
  
  METHODS
  A total of 118 consecutive nonpregnant women with a cytological diagnosis of ASCUS favoring either a reactive process or LSIL were evaluated in our colposcopy clinic by repeat cervical cytologic smear, colposcopy and colposcopically directed biopsies and/or endocervical curettage, as indicated.
  
  
  RESULTS
  Of the 58 patients evaluated for a smear of ASCUS, favoring a reactive process, 5 (8.6%) had cervical intraepithelial neoplasia (CIN) CIN 1 documented by biopsy. None had a high grade lesion. Twenty-six (45%) of the 58 patients who had a cytologic diagnosis of ASCUS favoring a reactive process had a repeat smear that was normal. None was found to have CIN. Of the 60 patients who had a cervical diagnosis of ASCUS favoring LSIL, 9 (15%) had CIN 1 or CIN 2. Nineteen (32%) of the 60 patients who had a cytologic diagnosis of ASCUS favoring LSIL had a repeat smear that was normal. One of these patients had CIN 1 on biopsy. The sensitivity of a repeat smear, in this limited series, after an initial smear of ASCUS favoring a reactive process is 100%, while it was 66% after an initial smear of ASCUS favoring LSIL.
  
  
  CONCLUSIONS
  This study showed that in our laboratory a cytologic diagnosis of ASCUS favoring either a reactive process or LSIL is associated with a very low risk that the patient is haboring CIN. In the patient whose initial smear shows ASCUS favoring a reactive process, a repeat smear that is normal is reassuring. The patient whose smear shows ASCUS favoring LSIL probably requires further evaluation even in the presence of a normal repeat smear.
authors.affiliation: Department of Obstetrics and Gynecology, Allegheny University, Philidelphia, Pennsylvania 19129, USA.
authors.forename: D
authors.initials: D
authors.lastname: Gonzalez
authors.forename: E
authors.initials: E
authors.lastname: Hernandez
authors.forename: L
authors.initials: L
authors.lastname: Anderson
authors.forename: P
authors.initials: P
authors.lastname: Heller
authors.forename: B F
authors.initials: BF
authors.lastname: Atkinson
mesh_terms: D000293:Adolescent; D000328:Adult; D002278:Carcinoma in Situ / Q000175:diagnosis* / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000473:pathology*; D002584:Cervix Uteri / Q000473:pathology*; D003127:Colposcopy; D004848:Epithelium / Q000473:pathology; D005260:Female; D017408:Guidelines as Topic; D006801:Humans; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D014626:Vaginal Smears