The metabolic roles, pharmacology, and toxicology of lysine.
L-lysine monohydrochloride (LMH) is widely available to the public as a nonprescription oral supplement. Most of the pharmaceutical-grade product is used as a suppressant of recurrent herpes simplex infections. Recent publications indicate the possibility of other therapeutic uses, e.g., in cardiovascular disease and osteoporosis. These and other potential applications are surveyed and evaluated in this review with suggestions for further study. Data on toxicity are reviewed and recommendations made regarding safety of chronic dosage levels.
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Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile 36688, USA.
D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy; D002561:Cerebrovascular Disorders / Q000188:drug therapy; D004044:Dietary Proteins / Q000378:metabolism* / Q000592:standards; D006561:Herpes Simplex / Q000188:drug therapy; D006801:Humans; D008239:Lysine / Q000378:metabolism / Q000627:therapeutic use / Q000633:toxicity; D009753:Nutritive Value; D010024:Osteoporosis / Q000188:drug therapy; D012008:Recurrence; D014452:Ubiquitins / Q000378:metabolism
D004044:Dietary Proteins; D014452:Ubiquitins; D008239:Lysine