The cloning of a human ABC gene (ABC3) mapping to chromosome 16p13.3.
The ATP binding cassette (ABC) transporters, or traffic ATPases, constitute a large family of proteins responsible for the transport of a wide variety of substrates across cell membranes in both prokaryotic and eukaryotic cells. We describe a human ABC protein with regions of strong homology to the recently described murine ABC1 and ABC2 transporters. The gene for this novel protein, human ABC3, maps near the polycystic kidney disease type 1 (PKD1) gene on chromosome 16p13.3. The ABC3 gene is expressed at highest levels in lung compared to other tissues.
Connors
T D
TD
Department of Human Genetics, Genzyme Genetics, Framingham, Massachusetts 01701, USA.
Van Raay
T J
TJ
Petry
L R
LR
Klinger
K W
KW
Landes
G M
GM
Burn
T C
TC
D018528:ATP-Binding Cassette Transporters / Q000235:genetics* / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D015870:Gene Expression; D006801:Humans; D008168:Lung / Q000378:metabolism; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
D018528:ATP-Binding Cassette Transporters