Epi-inositol is biochemically active in reversing lithium effects on cytidine monophosphorylphosphatidate (CMP-PA). Short communication.
In CHOm3 cells and rat cerebral cortex slices, epi-inositol was less potent but as effective as myo-inositol in reversing carbachol/lithium-stimulated CMP-PA accumulation whereas L-chiro- and scyllo-inositol were less active or inactive. These results with the four inositol isomers in two tissues correlate exactly with their effects on lithium-pilocarpine induced seizures and suggest a common mechanism of action for biochemical and behavioural effects.
Richards
M H
MH
Marion Merrell Research Institute, Strasbourg, France.
Belmaker
R H
RH
D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D003568:Cytidine Monophosphate / Q000031:analogs & derivatives* / Q000378:metabolism; D020404:Glycerophospholipids; D066298:In Vitro Techniques; D007294:Inositol / Q000378:metabolism*; D007536:Isomerism; D008094:Lithium / Q000494:pharmacology*; D010712:Phosphatidic Acids / Q000378:metabolism*; D051381:Rats; D011976:Receptors, Muscarinic / Q000235:genetics / Q000378:metabolism; D014162:Transfection
D020404:Glycerophospholipids; D010712:Phosphatidic Acids; D011976:Receptors, Muscarinic; C088379:cytidine monophosphorylphosphatidate; D007294:Inositol; D008094:Lithium; D003568:Cytidine Monophosphate