Resistance to UV-irradiation of DNA synthesis in fibroblast cell lines derived from LEC strain rats.
After UV-irradiation, no difference in the survival curves was observed among cell lines derived from LEC strain (LEC) rats and WKAH strain (WKAH) rats. The dose-response curves for inhibition of DNA synthesis in WKAH-derived cells showed a sharp decline at lower doses and a mild decline at higher doses of UV-rays. In contrast, the dose-response curves in LEC-derived cell lines had no sharp component, and were almost identical to the mild component of the curves in WKAH-derived cells. These results show that DNA synthesis in the cell lines of LEC rats was more resistant to UV-irradiation than that of WKAH rats.
Uehara
K
K
Department of Veterinary Radiology, Faculty of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan.
Arai
S
S
Okui
T
T
Hayashi
M
M
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects*; D004247:DNA / Q000096:biosynthesis* / Q000528:radiation effects; D004261:DNA Replication / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005347:Fibroblasts / Q000166:cytology / Q000528:radiation effects; D051381:Rats; D011919:Rats, Inbred Strains; D014466:Ultraviolet Rays
D004247:DNA