[Blood flow and free radical oxidation of lipids in gastric and duodenal mucosa in complicated duodenal ulcers].
38 patients with complicated duodenal ulcer were examined with polarographic method. The significant decrease of tissue blood flow was revealed in all segments of gastroduodenal zone. The increased level of free-radical oxidation of lipids was determined in duodenal mucosa and ulcer edges. Disorders of blood supply and activation of free-radical lipid oxidation play an important role in the mechanism of ulcer formation. The drugs improving blood supply and antioxidants should be used in combined therapy and preoperative preparation.
Potashov
L V
LV
Department of Common Surgery, Medical Institute of IP Pavlov, Saint-Petersburg.
Savranskii
V M
VM
Morozov
V P
VP
D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D001783:Blood Flow Velocity / Q000187:drug effects; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology*; D004386:Duodenum; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D005753:Gastric Mucosa / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care
D000897:Anti-Ulcer Agents; D000975:Antioxidants; D005609:Free Radicals