title: Distribution of apolipoprotein E gene polymorphisms in Japanese patients with Alzheimer's disease and in Japanese centenarians.
abstract: We have demonstrated an association between apolipoprotein E (apoE) gene polymorphisms and Alzheimer's disease (AD) in 163 Japanese patients by means of PCR. We found a significant increase in risk of nonfamilial AD for apoE allele epsilon4 in these individuals; this trend decreases with the increase in onset age. In centenarians, the distribution of apoE gene alleles is similar to that in the general population. The protective effect of allele epsilon2 against the development of AD is not statistically significant in our analysis. This indicates that apoE polymorphism is associated with AD regardless of race and that the age of onset is related to the apoE gene in the development of AD.
authors.affiliation: Health Care Center, Yamanashi University, Japan.
authors.forename: Z
authors.initials: Z
authors.lastname: Yamagata
authors.forename: T
authors.initials: T
authors.lastname: Asada
authors.forename: A
authors.initials: A
authors.lastname: Kinoshita
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: A
authors.initials: A
authors.lastname: Asaka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D001057:Apolipoproteins E