title: Malignant hemangioendothelioma of the left calcaneus associated with fever and hematological abnormalities.
abstract: A case of malignant hemangioendothelioma of the left calcaneus associated with unique system manifestations is reported here. The severe toxic manifestations included: high fever, anemia, leukocytosis, coagulation abnormalities, and other signs. Because of poor response to many antibiotic regimens, the confusion of diagnosis, and severe coagulation abnormalities with clinical signs that the life of the patient was endangered, below the knee amputation was performed. Pathological studies revealed a malignant hemangioendothelioma. A review of the case suggests that the signs and symptoms were possibly due to an immune response to the tumor rather than to secondary infection, although the latter possibility cannot be completely excluded.
authors.affiliation: Department of Orthopedic Surgery, Nagoya University, School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Rong
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: S
authors.initials: S
authors.lastname: Yamamura
authors.forename: H
authors.initials: H
authors.lastname: Sugiura
authors.forename: H
authors.initials: H
authors.lastname: Katagiri
authors.forename: H
authors.initials: H
authors.lastname: Iwata
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D002111:Calcaneus; D003131:Combined Modality Therapy; D005334:Fever / Q000150:complications* / Q000628:therapy; D005500:Follow-Up Studies; D006390:Hemangioendothelioma / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D006402:Hematologic Diseases / Q000150:complications* / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male