[Serotonin in diabetic retinopathy].
OBJECTIVE
The present study was designed to evaluate a possible participation of serotonin in the development of retinopathy in diabetes mellitus.


METHODS
Serotonin of whole blood and platelets was studied in 12 patients with Type I and II diabetes using high pressure liquid chromatography method.


RESULTS
The concentration of serotonin in the blood was markedly increased (210 +/- 50 ng/ml in diabetes and 150 +/- 35 ng/ml in control, p < 0.01) and not changed in platelets in diabetes. There was a relation between blood serotonin level and the presence of retinopathy.


CONCLUSIONS
These results suggest that serotonin may be involved in the pathogenesis of diabetic microangiopathy.
Andrzejewska-Buczko
J
J
Kliniki Okulistycznej AM w Białymstoku.
Pawlak
D
D
Walkowiak
M
M
Stankiewicz
A
A
D000368:Aged; D001792:Blood Platelets / Q000737:chemistry; D003920:Diabetes Mellitus / Q000097:blood; D003930:Diabetic Retinopathy / Q000097:blood*; D005260:Female; D006801:Humans; D012701:Serotonin / Q000097:blood*
D012701:Serotonin