title: Effects of calcisorb on fecal bile acids and fatty acids in human volunteers.
abstract: The intake of calcium (Ca) is negatively associated with colorectal cancer (crc) risk. The aim of this study was to investigate in a double-blind, placebo-controlled trial, the effects of the Ca-binder Calcisorb, which is given to kidney stone patients with hypercalciuria type I, on risk factors for crc risk, bile acids (BA), and long-chain fatty acids (LCFA) in fecal water. Results show that the concentration of BA and LCFA in fecal water did not change, although the urinary excretion of Ca and magnesium (Mg) and the concentration of Ca and magnesium in fecal water decreased. The daily excretion of BA and LCFA acids decreased significantly (p < 0.05) during the Calcisorb period. In conclusion, binding dietary Ca and Mg with Calcisorb from a diet with a relatively low amount of fat does not enhance the solubility of BA and LCFA in fecal water.
authors.affiliation: Department of Urology, University Hospital Maastricht, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: van Faassen
authors.forename: A E
authors.initials: AE
authors.lastname: van den Bogaard
authors.forename: M J
authors.initials: MJ
authors.lastname: Hazen
authors.forename: P
authors.initials: P
authors.lastname: Geerlings
authors.forename: R J
authors.initials: RJ
authors.lastname: Hermus
authors.forename: R A
authors.initials: RA
authors.lastname: Janknegt
mesh_terms: D000328:Adult; D001647:Bile Acids and Salts / Q000032:analysis*; D002118:Calcium / Q000652:urine; D002482:Cellulose / Q000031:analogs & derivatives* / Q000494:pharmacology; D004311:Double-Blind Method; D005227:Fatty Acids / Q000032:analysis*; D005243:Feces / Q000737:chemistry*; D006801:Humans; D008274:Magnesium / Q000652:urine; D008297:Male; D012016:Reference Values; D012307:Risk Factors
chemical_list: D001647:Bile Acids and Salts; D005227:Fatty Acids; D002482:Cellulose; C008881:phosphocellulose; D008274:Magnesium; D002118:Calcium