Venlafaxine and metabolites are very weak inhibitors of human cytochrome P450-3A isoforms.
von Moltke
L L
LL
Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA.
Duan
S X
SX
Greenblatt
D J
DJ
Fogelman
S M
SM
Schmider
J
J
Harmatz
J S
JS
Shader
R I
RI
D000525:Alprazolam / Q000493:pharmacokinetics; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D001189:Aryl Hydrocarbon Hydroxylases; D001711:Biotransformation; D003511:Cyclohexanols / Q000494:pharmacology*; D051544:Cytochrome P-450 CYP3A; D065607:Cytochrome P-450 Enzyme Inhibitors; D004347:Drug Interactions; D018757:GABA Modulators / Q000493:pharmacokinetics; D006801:Humans; D066298:In Vitro Techniques; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D010089:Oxidoreductases, N-Demethylating / Q000037:antagonists & inhibitors*; D000069470:Venlafaxine Hydrochloride
D018687:Antidepressive Agents, Second-Generation; D003511:Cyclohexanols; D065607:Cytochrome P-450 Enzyme Inhibitors; D018757:GABA Modulators; D007527:Isoenzymes; D000069470:Venlafaxine Hydrochloride; D001189:Aryl Hydrocarbon Hydroxylases; D051544:Cytochrome P-450 CYP3A; D010089:Oxidoreductases, N-Demethylating; D000525:Alprazolam