Selection of amino acid parameters for Fourier transform-based analysis of proteins.
Fourier analysis of the parametric profile of a sequence for the detection and localization of the structural motifs that are characteristic for biologically related proteins has been proposed. In order to select parameters that are most appropriate for this analysis, the informational capacity of 226 physicochemical, thermodynamic, structural and statistical amino acid parameters was analyzed. Based on the results, obtained for the four functionally unrelated protein model groups (lysozyme c, HIV-1 gp120, tubulin and tau proteins, and steroid hormone receptors), the electron-ion interaction potential has been selected as the unique amino acid property that can be used in Fourier transform-based analysis of proteins, independently of their biological function.
Lazović
J
J
Laboratory for Multidisciplinary Research 180/2, Institute of Nuclear Sciences Vinća, Belgrade, Yugoslavia. elazovij@ubbg.etf.bg.ac.yu
D000213:Acyl Carrier Protein / Q000737:chemistry / Q000235:genetics; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003196:Computer Graphics; D004563:Electrochemistry; D005583:Fourier Analysis; D006801:Humans; D008969:Molecular Sequence Data; D015394:Molecular Structure; D011506:Proteins / Q000737:chemistry / Q000235:genetics*; D017421:Sequence Analysis / Q000706:statistics & numerical data*; D013816:Thermodynamics
D000213:Acyl Carrier Protein; D000596:Amino Acids; D001426:Bacterial Proteins; D011506:Proteins