Membrane immunoglobulin-associated molecules on channel catfish B lymphocytes.
Membrane immunoglobulin (mIgM) on the surface of channel catfish B lymphocytes is non-covalently associated with 64 and 70 kDa molecules which are composed of covalent 32 kDa dimers and covalent 45/25 kDa subunits, respectively. Cross-linking of mIgM on catfish B cells leads to rapid phosphorylation of tyrosine residues in these presumed accessory as well as numerous other cytoplasmic molecules. These data indicate that fish likely use a signal transduction system containing elements similar to those of mammalian B cells.
Rycyzyn
M A
MA
Department of Microbiology, University of Mississippi Medical Center, Jackson 39216, USA.
Wilson
M R
MR
Warr
G W
GW
Clem
L W
LW
Miller
N W
NW
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D007059:Ictaluridae / Q000276:immunology*; D008565:Membrane Proteins / Q000276:immunology* / Q000378:metabolism*; D010766:Phosphorylation; D011485:Protein Binding / Q000276:immunology; D011947:Receptors, Antigen, B-Cell / Q000276:immunology* / Q000378:metabolism*
D008565:Membrane Proteins; D011947:Receptors, Antigen, B-Cell