title: Expression of the surface antigen A2B7 in adult and developing honeybee olfactory pathway.
abstract: In order to identify molecules involved in the development of the honeybee olfactory pathway, hybridoma technology has been used. Among different cell lines, A2B7 has been selected. It produces a specific antibody for a surface glycoprotein of 91 kDa. This protein is mainly expressed by both the antennal receptor cells and mushroom body neurons. Based on (i) the spatio-temporal pattern of expression during pupal development; (ii) the cell surface location of the antigen; and (iii) the partial molecular characterization of the antigen, a putative role for this protein in axonal fasciculation and guidance is discussed.
authors.affiliation: Laboratoire de Neurobiologie Comparée des Invertébrés, INRA-CNRS (URA 1190), Bures-sur-Yvette, France.
authors.forename: J
authors.initials: J
authors.lastname: Gascuel
authors.forename: F
authors.initials: F
authors.lastname: Brouillard
authors.forename: C
authors.initials: C
authors.lastname: Papin
authors.forename: C
authors.initials: C
authors.lastname: Masson
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface / Q000096:biosynthesis* / Q000235:genetics; D001369:Axons / Q000502:physiology; D001516:Bees / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006031:Glycosylation; D006825:Hybridomas / Q000276:immunology; D019476:Insect Proteins / Q000096:biosynthesis* / Q000235:genetics; D008675:Metamorphosis, Biological; D051379:Mice; D008807:Mice, Inbred BALB C; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics; D009474:Neurons / Q000145:classification / Q000378:metabolism* / Q000648:ultrastructure; D009833:Olfactory Pathways / Q000254:growth & development / Q000378:metabolism*; D018034:Olfactory Receptor Neurons / Q000378:metabolism / Q000648:ultrastructure; D011499:Protein Processing, Post-Translational; D011679:Pupa
chemical_list: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D019476:Insect Proteins; D009419:Nerve Tissue Proteins; C105899:antigen A2B7, honeybee