Time-related effects of stress on cholinergic sensitivity.
The effect of the administration of the muscarinic cholinergic agonist oxotremorine on locomotor activity was investigated in DBA/2 mice subjected to chronic restraint stress of different durations (120 min daily for 10, 14 or 18 days). Oxotremorine induced a depressant effect on locomotion, which was reduced after 10 and 14 days of restraint, but not after a 18-day restraint stress. Acetylcholine (ACh) content was significantly reduced in prefrontal cortex after 10 and 14 days of stress but returned to control values after 18 days of restraint. No changes in ACh content were observed in nucleus accumbens and striatum. These results are discussed in terms of possible changes in muscarinic receptor sensitivity.
Pullia
D
D
Istituto di Psicobiologia e Psicofarmacologia, CNR, Roma, Italy.
D'Amato
F R
FR
Mele
A
A
Oliverio
A
A
Zocchi
A
A
Pavone
F
F
D000109:Acetylcholine / Q000378:metabolism*; D000223:Adaptation, Psychological / Q000187:drug effects; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009043:Motor Activity / Q000187:drug effects*; D018721:Muscarinic Agonists / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism; D010095:Oxotremorine / Q000494:pharmacology*; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000378:metabolism*; D013997:Time Factors
D018721:Muscarinic Agonists; D010095:Oxotremorine; D000109:Acetylcholine