title: Mechanisms of induction of chromosomal aberrations and their detection by fluorescence in situ hybridization.
abstract: Fluorescence in situ hybridization (FISH) technique using chromosome specific probes has revolutionized the field of radiation cytogenetics in the last few years. Some of the new insights on the origins of radiation induced chromosome aberrations in human, mouse and Chinese hamster, using FISH are reviewed in this paper.
authors.affiliation: MGC Department of Radiation Genetics and Chemical Mutagenesis, Leiden University, The Netherlands.
authors.forename: A T
authors.initials: AT
authors.lastname: Natarajan
authors.forename: A S
authors.initials: AS
authors.lastname: Balajee
authors.forename: J J
authors.initials: JJ
authors.lastname: Boei
authors.forename: F
authors.initials: F
authors.lastname: Darroudi
authors.forename: I
authors.initials: I
authors.lastname: Dominguez
authors.forename: M P
authors.initials: MP
authors.lastname: Hande
authors.forename: M
authors.initials: M
authors.lastname: Meijers
authors.forename: P
authors.initials: P
authors.lastname: Slijepcevic
authors.forename: S
authors.initials: S
authors.lastname: Vermeulen
authors.forename: Y
authors.initials: Y
authors.lastname: Xiao
mesh_terms: D000818:Animals; D016466:CHO Cells; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects*; D006224:Cricetinae; D003412:Cricetulus; D015342:DNA Probes; D004260:DNA Repair; D005347:Fibroblasts; D016193:G1 Phase; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*; D008214:Lymphocytes; D051379:Mice; D016192:Resting Phase, Cell Cycle; D013154:Spleen / Q000166:cytology; D014740:Vidarabine / Q000494:pharmacology
chemical_list: D015342:DNA Probes; D014740:Vidarabine