Severe humoral hypercalcemia in primary isolated non-Hodgkin's lymphoma of the heart.
The etiology of hypercalcemia was investigated in a patient with primary isolated non-Hodgkin's lymphoma of the heart. There was no evidence of bone involvement, and parathyroid hormone and calciterol levels were suppressed. Plasma parathyroid-hormone-related protein (PTHrP 1-86) detected by immunoradiometric assay was increased (15 pmol/l compared with < 0.3 pmol/l in a control). We demonstrated that PTHrP was the humoral mediator of severe hypercalcemia in our patient.
Yigla
M
M
Division of Pulmonary Diseases, Northern Israel Oncology of Center, Haifa, Israel.
Ben-Arieh
Y
Y
Beny
A
A
Milo
S
S
Markiewicz
W
W
Reisner
S A
SA
D006338:Heart Neoplasms / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000209:etiology*; D015592:Immunoradiometric Assay; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D044162:Parathyroid Hormone-Related Protein; D010446:Peptide Fragments / Q000097:blood; D010455:Peptides / Q000097:blood
D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D010446:Peptide Fragments; D010455:Peptides; C068871:parathyroid hormone-related protein (1-86)