The successful use of hyperstimulated washed therapeutic donor insemination after standard therapeutic donor insemination has failed.
OBJECTIVE
To investigate whether an aggressive therapeutic donor insemination regimen (stimulated folliculogenesis and ovulation plus intrauterine insemination) can produce a better fecundability rate than a more traditional insemination regimen (non-stimulated folliculogenesis plus LH-timed intracervical insemination) in women who have failed to become pregnant during an initial series of six traditional insemination cycles.


METHODS
A retrospective comparison of fecundability rates was undertaken between women undergoing the traditional insemination protocol and those who voluntarily switched to ovarian hyperstimulation coupled with intrauterine insemination.


METHODS
Eight-two women who failed to become pregnant during an initial series of six intracervical insemination cycles.


RESULTS
Fecundability was 5.6% in cycles of continued urinary LH-timed intracervical insemination and 19.4% when the more aggressive regimen was applied. The difference in fecundability between protocols was significant (P < .005).


CONCLUSIONS
After an initial series of donor inseminations has failed, a more aggressive insemination regimen involving ovarian hyperstimulation followed by washed intrauterine insemination provides a higher fecundability rate than continued intracervical insemination.
Dow
M P
MP
Department of Obstetrics and Gynecology, Medical School, University of Wisconsin, Madison, USA.
Jones
J M
JM
Dumesic
D A
DA
Lu
Y
Y
Shapiro
S S
SS
D000328:Adult; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D002996:Clomiphene / Q000494:pharmacology; D015331:Cohort Studies; D015925:Cryopreservation; D005260:Female; D005298:Fertility / Q000187:drug effects; D005300:Fertility Agents, Female / Q000494:pharmacology*; D006801:Humans; D007316:Insemination, Artificial, Heterologous / Q000379:methods*; D008596:Menotropins / Q000494:pharmacology; D010053:Ovary / Q000187:drug effects* / Q000502:physiology; D018873:Pregnancy Rate; D012189:Retrospective Studies; D012662:Semen Preservation
D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D002996:Clomiphene; D008596:Menotropins