Vesicular transport: implications for cell polarity.
In polarized cells intracellular sorting of plasma membrane proteins occurs to a large extent at the trans-Golgi network, giving rise to vesicles destined for distinct plasma membrane domains. This review discusses the several pathways, both direct and indirect, which lead to protein incorporation into the correct cell surface, as well as the mechanisms involved. Proteins contain signals which direct their incorporation into the distinct vesicles destined for plasma membrane microdomains. Specific coat proteins are involved in vesicle assembly and are likely to play a role in the generation of discrete vesicle populations. Molecules involved in vesicle docking and fusion may also add specificity to the targeting process.
Burdick
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Cornell University Medical College, Dyson Institute for Vision Research, New York, NY 10021, USA.
Le Gall
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AH
Rodriguez-Boulan
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D000595:Amino Acid Sequence; D000818:Animals; D001692:Biological Transport; D002460:Cell Line; D016764:Cell Polarity; D018699:Coated Vesicles / Q000502:physiology*; D004285:Dogs; D006056:Golgi Apparatus / Q000378:metabolism; D007668:Kidney; D008561:Membrane Fusion; D008565:Membrane Proteins / Q000145:classification / Q000378:metabolism* / Q000502:physiology; D008954:Models, Biological; D008969:Molecular Sequence Data; D015388:Organelles / Q000378:metabolism; D021382:Protein Sorting Signals / Q000378:metabolism; D050600:SNARE Proteins; D014443:Tyrosine / Q000502:physiology; D033921:Vesicular Transport Proteins
D008565:Membrane Proteins; D021382:Protein Sorting Signals; D050600:SNARE Proteins; D033921:Vesicular Transport Proteins; D014443:Tyrosine