Anticandidal activity of Santolina chamaecyparissus volatile oil.
A search for naturally occurring drugs with antifungal activity lead to Santolina oil, a volatile oil distillate of Santolina chamaecyparissus. The studies revealed that Santolina oil was effective in controlling experimental candidiasis in vitro and in vivo. It had a synergistic effect on clotrimazole in controlling Candida albicans in vitro. It significantly controlled experimental vaginal candidiasis and experimental systemic candidosis. Santolina oil was able to control the superficial cutaneous mycoses. It is recommended as a potential candidate for further studies, including clinical studies.
Suresh
B
B
Department of Pharmacology, J.S.S. College of Pharmacy, Tamil Nadu, India.
Sriram
S
S
Dhanaraj
S A
SA
Elango
K
K
Chinnaswamy
K
K
D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002176:Candida albicans / Q000187:drug effects*; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy*; D003022:Clotrimazole / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D003881:Dermatomycoses / Q000139:chemically induced / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D006168:Guinea Pigs; D018859:Hair Follicle / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009822:Oils, Volatile / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000935:Antifungal Agents; D009822:Oils, Volatile; D010938:Plant Oils; D003022:Clotrimazole