title: [Nephropathies in a region contaminated by heavy metal salts and the possibilities for therapeutic and prophylactic measures].
abstract: The study of the population in the region contaminated with heavy metal salts has revealed high incidence of nephropathies even in preschool children manifesting initially in the majority of cases with hematuria. All the patients had the signs of urinary dysembryogenesis and marked membranopathological process. Long-term exposure to even small doses of heavy metals is supposed to cause nephropathy. Urinary disease arose more frequently in those genetically predisposed to renal and urinary tract affections. Because urolithiasis is a frequent result of dismetabolic nephropathy in endemic regions, it is advisable to perform active monitoring of children with environmental nephropathy using membrane-stabilizing measures. Optimal for these purpose could be xidifon. Further studies are needed to elucidate the problem of rapid elimination of heavy metals with chelating agents.
authors.forename: M S
authors.initials: MS
authors.lastname: Ignatova
authors.forename: E A
authors.initials: EA
authors.lastname: Kharina
authors.forename: V V
authors.initials: VV
authors.lastname: Dlin
authors.forename: O N
authors.initials: ON
authors.lastname: Trukhina
authors.forename: E A
authors.initials: EA
authors.lastname: Iur'eva
authors.forename: M I
authors.initials: MI
authors.lastname: Osmanov
authors.forename: I V
authors.initials: IV
authors.lastname: Balkarov
mesh_terms: D000293:Adolescent; D000328:Adult; D002614:Chelating Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004198:Disease Susceptibility; D004785:Environmental Pollutants / Q000009:adverse effects* / Q000652:urine; D005260:Female; D006417:Hematuria / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy / Q000517:prevention & control; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy* / Q000517:prevention & control; D008297:Male; D019216:Metals, Heavy / Q000009:adverse effects* / Q000652:urine; D012426:Russia; D014505:Urban Population
chemical_list: D002614:Chelating Agents; D004785:Environmental Pollutants; D019216:Metals, Heavy