title: [Microbiological studies of a nasal positive pressure respirator with and without a humidifier system].
abstract: 13 patients with obstructive sleep apnea syndrome treated with CPAP-therapy and complicating affections of the nasal and pharyngeal mucosa were enrolled in a randomized cross-over study comparing therapy with a heated humidifier (HC 100, company Fisher & Paykel) and treatment with a heat and moisture exchanger (Typ I, company Dahlhausen). We assessed the bacterial and fungal colonisation of the nasal masks of all patients. Samples of mask rinses were taken after the two treatment periods (2 weeks each) and the period without humidification in between. All microbes were found to have pathological potency. There was no significant difference in the total concentration of the microbes in the different treatment modalities. In a few cases however, gram negative bacteria were detected on the masks during humidification with a heated humidifier, but not with heat and moisture exchangers. Legionella spec. were not detectable in any of the samples. Candida albicans was the only fungus detectable. No patient had any infection of the upper or lower respiratory system associated with humidification therapy.
authors.affiliation: Abteilung Innere Medizin II, Universitätsklinik Ulm, Deutschland.
authors.forename: J
authors.initials: J
authors.lastname: Hetzel
authors.forename: S
authors.initials: S
authors.lastname: Herb
authors.forename: M
authors.initials: M
authors.lastname: Hetzel
authors.forename: T
authors.initials: T
authors.lastname: Rusteberg
authors.forename: G
authors.initials: G
authors.lastname: Kleiser
authors.forename: J
authors.initials: J
authors.lastname: Weber
authors.forename: M
authors.initials: M
authors.lastname: Kochs
authors.forename: V
authors.initials: V
authors.lastname: Hombach
mesh_terms: D000328:Adult; D000368:Aged; D000391:Air Microbiology; D015169:Colony Count, Microbial; D004866:Equipment Contamination; D005260:Female; D006801:Humans; D006813:Humidity; D008297:Male; D008875:Middle Aged; D011175:Positive-Pressure Respiration / Q000295:instrumentation*; D012307:Risk Factors; D012891:Sleep Apnea Syndromes / Q000382:microbiology / Q000628:therapy*