Involvement of pre- and postsynaptic mechanisms in posttetanic potentiation at Aplysia synapses.
Posttetanic potentiation (PTP) is a common form of short-term synaptic plasticity that is generally thought to be entirely presynaptic. Consistent with that idea, PTP of evoked excitatory postsynaptic potentials at Aplysia sensory-motor neuron synapses in cell culture was reduced by presynaptic injection of a slow calcium chelator and was accompanied by an increase in the frequency but not the amplitude of spontaneous excitatory postsynaptic potentials. However, PTP was also reduced by postsynaptic injection of a rapid calcium chelator or postsynaptic hyperpolarization. Thus, PTP at these synapses is likely to involve a postsynaptic induction mechanism in addition to the known presynaptic mechanisms.
Bao
J X
JX
Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Kandel
E R
ER
Hawkins
R D
RD
D020003:1-Octanol; D000200:Action Potentials; D000818:Animals; D001048:Aplysia; D002118:Calcium / Q000502:physiology; D002478:Cells, Cultured; D002614:Chelating Agents / Q000494:pharmacology; D004533:Egtazic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D017774:Long-Term Potentiation; D009046:Motor Neurons / Q000502:physiology*; D009473:Neuronal Plasticity; D009475:Neurons, Afferent / Q000502:physiology*; D000442:Octanols / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission
D002614:Chelating Agents; D000442:Octanols; D012701:Serotonin; D004533:Egtazic Acid; C025603:1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid; D020003:1-Octanol; D002118:Calcium