title: An analysis of valve re-replacement after aortic valve replacement with biologic devices.
abstract: Biologic valve re-replacement was examined in a series of 1343 patients who underwent aortic valve replacement at The Prince Charles Hospital, Brisbane, with a cryopreserved or 4 degrees C stored allograft valve or a xenograft valve. A parametric model approach was used to simultaneously model the competing risks of death without re-replacement and re-replacement before death. One hundred eleven patients underwent a first re-replacement for a variety of reasons (69 patients with xenograft valves, 28 patients with 4 degrees C stored allograft valves, and 14 patients with cryopreserved allograft valves). By multivariable analysis younger age at operation was associated with xenograft, 4 degrees C stored allograft, and cryopreserved allograft valve re-replacement. However, this effect was examined in the context of longer survival of younger patients, which increases their exposure to the risk of re-replacement as compared with that in older patients whose decreased survival reduced their probability of requiring valve re-replacement. In patients older than 60 years at the time of aortic valve replacement, the probability of re-replacement (for any reason) before death was similar for xenografts and cryopreserved allograft valves but higher for 4 degrees C stored valves. However, in patients younger than 60 years, the probability of re-replacement at any time during the remainder of the life of the patient was lower with the cryopreserved allograft valve compared with the xenograft valve and 4 degrees C stored allografts.
authors.affiliation: Department of Cardiac Surgery, Prince Charles Hospital, Queensland, Australia.
authors.forename: D C
authors.initials: DC
authors.lastname: McGiffin
authors.forename: A J
authors.initials: AJ
authors.lastname: Galbraith
authors.forename: M F
authors.initials: MF
authors.lastname: O'Brien
authors.forename: G J
authors.initials: GJ
authors.lastname: McLachlan
authors.forename: D C
authors.initials: DC
authors.lastname: Naftel
authors.forename: P
authors.initials: P
authors.lastname: Adams
authors.forename: S
authors.initials: S
authors.lastname: Reddy
authors.forename: L
authors.initials: L
authors.lastname: Early
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000601:surgery; D001705:Bioprosthesis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous