title: Effect of cytomegalovirus infection status on first-year mortality rates among orthotopic liver transplant recipients. The Boston Center for Liver Transplantation CMVIG Study Group.
abstract: BACKGROUND
  To reduce the mortality rate associated with liver transplantation, it is important to identify the risk factors for increased mortality among liver transplant recipients. It has been suggested that cytomegalovirus (CMV) infection is one such risk factor, but no studies have examined mortality rates associated with the CMV serologic status of the donor and recipient by using multivariate techniques.
  
  
  OBJECTIVE
  To study the effect of CMV on 1-year mortality rates in orthotopic liver transplant recipients.
  
  
  METHODS
  Intention-to-treat analysis of a cohort.
  
  
  METHODS
  146 liver transplant recipients who were enrolled in a multicenter, randomized, placebo-controlled intervention trial.
  
  
  METHODS
  Four university-affiliated transplantation centers.
  
  
  RESULTS
  1-year mortality rates for the four strata of donor and recipient CMV serologic status before transplantation were as follows: seronegative donor and recipient, 11%; seronegative donor and seropositive recipient, 22%; seropositive donor and recipient, 30%; and seropositive donor and seronegative recipient, 44% (P = 0.0091). Multivariate analysis using a time-dependent Cox proportional hazards model showed that retransplantation (relative risk, 4.6 [95% CI, 1.9 to 10.7]; P < 0.001); total number of units of blood products administered during transplantation (relative risk, 1.006 per unit [CI, 1.003 to 1.010]; P < 0.001); and presence of CMV disease (relative risk, 3.9 [CI, 1.8 to 8.5]; P < 0.001), invasive fungal disease (relative risk, 3.3 [CI, 1.5 to 7.1]; P = 0.0020), and bacteremia (relative risk, 2.5 [CI, 1.2 to 5.2]; P = 0.0136) were independently associated with higher mortality rates. If post-transplantation variables that were highly correlated with donor and recipient CMV serologic status were restricted from the model, donor and recipient CMV serologic status was the only pretransplantation variable independently associated with higher mortality rates (P = 0.002).
  
  
  CONCLUSIONS
  Donor and recipient CMV serologic status is a significant pretransplantation determinant for death in liver transplant recipients.
authors.affiliation: New England Medical Center, Boston, Massachusetts, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Falagas
authors.forename: D R
authors.initials: DR
authors.lastname: Snydman
authors.forename: J
authors.initials: J
authors.lastname: Griffith
authors.forename: R
authors.initials: R
authors.lastname: Ruthazer
authors.forename: B G
authors.initials: BG
authors.lastname: Werner
mesh_terms: D000328:Adult; D003586:Cytomegalovirus Infections / Q000175:diagnosis*; D004311:Double-Blind Method; D005500:Follow-Up Studies; D006801:Humans; D016031:Liver Transplantation / Q000401:mortality*; D008875:Middle Aged; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000175:diagnosis*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D014766:Viremia / Q000175:diagnosis*