[The binding of drugs with erythrocytes].
The article reviews the data on the binding of drugs to erythrocytes. Various mechanisms of the uptake of drugs by the erythrocytes and the role of the red blood cells as carriers of the drugs to the target organs are discussed. Significant correlation of the clinical and pharmacological effect of many drugs with their content in the erythrocytes is shown. Determination of the pharmacological parameters from the content of the drugs in the erythrocytes or whole blood rather than in the plasma is recommended.
Gneushev
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Gneusheva
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D000818:Animals; D001693:Biological Transport, Active; D001798:Blood Proteins / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010949:Plasma / Q000378:metabolism
D001798:Blood Proteins; D004364:Pharmaceutical Preparations