Effect of interferon-alpha on DOI-induced wet-dog shakes in rats.
Acute (1 h) intraperitoneal (i.p.) treatment with interferon (IFN)-alpha-2a (300 IU/g) significantly inhibited wet-dog shakes (WDS) induced by (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane (DOI; 0.5, 1.0 mg/kg), which is mediated by serotonin (5-hydroxytryptamine; 5-HT)2 receptor in rats. IFN-alpha did not affect spontaneous locomotion. The inhibition of DOI (0.5 mg/kg)-induced WDS by IFN-alpha was dose (90-300 IU/g)- and time (1-6 h)-dependent, and was prevented by 30 min pretreatment with naltrexone (NLTX; 1.0 mg/kg, i.p.), an opioid receptor antagonist. Acute (1 h) intracerebroventricular (i.c.v.) treatment with IFN-alpha (1,500 IU/rat) also inhibited DOI (0.5 mg/kg)-induced WDS, and the effect was blocked by NLTX (50 micrograms/rat, i.c.v.). These results suggest that IFN-alpha may modulate 5-HT2 receptor-mediated behavior through opioid receptors in the central nervous system.
Kugaya
A
A
Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Japan.
Kagaya
A
A
Uchitomi
Y
Y
Yokota
N
N
Yamawaki
S
S
D000662:Amphetamines / Q000037:antagonists & inhibitors*; D000704:Analysis of Variance; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000494:pharmacology*; D008297:Male; D019964:Mood Disorders / Q000503:physiopathology*; D009043:Motor Activity / Q000187:drug effects*; D009271:Naltrexone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000502:physiology*; D011994:Recombinant Proteins; D017366:Serotonin Receptor Agonists / Q000633:toxicity*
D000662:Amphetamines; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D009292:Narcotic Antagonists; D011985:Receptors, Serotonin; D011994:Recombinant Proteins; D017366:Serotonin Receptor Agonists; D009271:Naltrexone; C015952:4-iodo-2,5-dimethoxyphenylisopropylamine