[Smoking and pregnancy: search for a correlation between cotininemia and Doppler findings].
OBJECTIVE
To search for a possible correlation between an effective marker of smoking and uterine and placental resistance during pregnancy.


METHODS
A prospective study was conducted at the Intercommunal Hospital Center of Montreuil, France: 81 healthy pregnant women underwent uterine and placental Doppler and cotidin blood assay, the best current test for smoking.


RESULTS
This study shows a significative increase of utero-placental vascular resistances according with increased cotidine levels.


CONCLUSIONS
The previously observed association between smoking and perinatal events most likely involves vascular resistance of uterus and placenta.
Lymperopoulou
A
A
Service de Gynécologie-Obstétrique, Centre Hospitalier Intercommunal, Montreuil.
Hainaut
F
F
Crimail
P
P
Durand
J L
JL
Locatelli
C
C
Maison
C
C
D000328:Adult; D015415:Biomarkers / Q000097:blood; D003367:Cotinine / Q000097:blood*; D005260:Female; D006801:Humans; D021041:Placental Circulation; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000000981:diagnostic imaging*; D011446:Prospective Studies; D012907:Smoking / Q000097:blood*; D016216:Ultrasonography, Prenatal; D014655:Vascular Resistance
D015415:Biomarkers; D003367:Cotinine