Possible roles of inositol 1,4,5-trisphosphate 3-kinase B in calcium homeostasis.
Some aspects of the roles of inositol trisphosphate (Insp3) and inositol tetrakisphosphate (Insp4) in Ca2+ homeostasis in terms of inositol trisphosphate 3-kinase B (IP3K-B) localization and activity are discussed. The model that we propose is also compatible with IP3K-B participating in the widely reported phenomenon of quantal release of Ca2+ from internal stores, at least in some biological systems.
Soriano
S
S
Department of Biochemistry and BBSRC-funded Molecular Recognition Centre, University of Bristol, UK.
Banting
G
G
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D004789:Enzyme Activation; D005455:Fluorescent Antibody Technique; D006706:Homeostasis / Q000502:physiology*; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D053496:Inositol 1,4,5-Trisphosphate Receptors; D007295:Inositol Phosphates / Q000378:metabolism; D008954:Models, Biological; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000502:physiology*; D051381:Rats; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D015398:Signal Transduction
D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D007295:Inositol Phosphates; D018160:Receptors, Cytoplasmic and Nuclear; C081655:inositol-1,3,4,5-tetrakisphosphate; D015544:Inositol 1,4,5-Trisphosphate; D017853:Phosphotransferases (Alcohol Group Acceptor); C051038:Inositol 1,4,5-trisphosphate 3-kinase; D002118:Calcium