[Efficacy of chemotherapy of pulmonary tuberculosis drug-resistant m.tuberculosis].
M. tuberculosis examined in 717 patients with pulmonary tuberculosis appeared resistant to chemotherapy in 67.2% of cases. Whereas chronic patients developed drug resistance (DR) as secondary DR in 90.2% of cases, new cases with DR (50.1% of the examinees) seemed to be infected with drug-resistant M. tuberculosis. 2-stage chemotherapy with 4-5 drugs terminates bacterial discharge within first 3 months of treatment in the majority of the patients, especially if early correction of chemotherapy is used by the results of early determination M. tuberculosis drug sensitivity.
Khomenko
A G
AG
Central NII of Tuberculosis RAMN, Moscow.
Chukanov
V I
VI
Korneev
A A
AA
D000995:Antitubercular Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000382:microbiology
D000995:Antitubercular Agents