title: [Anamnestic and polygraphic parameters in obstructive sleep apnea syndrome patients with reduced nasal respiration during the day in comparison with obstructive sleep apnea patients with normal nasal respiration].
abstract: Nasal obstruction is a predictive factor for snoring and may contribute to the development of an obstructive sleep apnea syndrome (OSAS). The aim of this study was to further evaluate the impact of nasal obstruction in OSAS. Therefore, we investigated 2 groups of OSAS-patients, matched pairs concerning gender, age, and BMI: OSAS-patients with nasal obstruction (N, n = 28), total nasal airflow < 500 ccm/s (referred to 150 pa pressure of difference or unilateral nasal resistance > 1 pa/ccm/s), and 28 OSAS-patients without nasal obstruction (control-group K, total nasal airflow > 700 ccm/s [referred to 150 pa pressure of difference or unilateral nasal resistance > 1 pa/ccm/s]). We performed anterior rhinomanometry, lung-function testing, cardio-respiratory polygraphy, and patients answered a standardized questionnaire. We found the following significant differences: 1) N complained more often (n = 17) about dyspnea at night than K (n = 7, p < 0.05, Chi2-test). 2) N had a higher apnea index (20.4 +/- 19.0/h) than K (9.6 +/- 10.0/h, p < 0.05, Student's t-test). There were, however, no significant differences concerning lung function, number of nocturnal hypopneas, nocturnal SaO2 and heart rate. Our results underline the importance of nasal ventilation in the pathogenesis of OSAS. At least in moderate cases of OSAS a therapy of nasal obstruction might be of success in order to abolish nCPAP-therapy or might reduce nasal problems during nCPAP-therapy and thus ameliorate patient's therapy compliance.
authors.affiliation: Berufsgenossenschaftlichen Kliniken Bergmannshell, Universitätsklinik/Ruhr-Universität Bochum, Deutshland.
authors.forename: H W
authors.initials: HW
authors.lastname: Duchna
authors.forename: K
authors.initials: K
authors.lastname: Rasche
authors.forename: M
authors.initials: M
authors.lastname: Orth
authors.forename: T T
authors.initials: TT
authors.lastname: Bauer
authors.forename: G
authors.initials: G
authors.lastname: Schultze-Werninghaus
mesh_terms: D000403:Airway Resistance / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015508:Nasal Obstruction / Q000175:diagnosis / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood; D011175:Positive-Pressure Respiration; D012123:Pulmonary Ventilation / Q000502:physiology; D012891:Sleep Apnea Syndromes / Q000175:diagnosis / Q000503:physiopathology*
chemical_list: D010100:Oxygen