title: Evaluation of some acylamide derivatives as potential hypoglycemic agents.
abstract: A series of new acylamide derivatives with piperidine, pyrrolidinyl and alanyl have been tested for their hypoglycemic activities. 2-(Pyrrolidynyl)-N-(3-chlorophenyl) acetamide and 2-(Piperazinyl)-N-(4-methoxy phenyl) acetamide were found most active hypoglycemic compounds. Probably the amides have mode of action similar to sulphonylureas.
authors.affiliation: Dept. of Pharmaceutics, I.T., Varanasi, India.
authors.forename: V
authors.initials: V
authors.lastname: Srivastava
authors.forename: A J
authors.initials: AJ
authors.lastname: Suresh
authors.forename: S N
authors.initials: SN
authors.lastname: Pandeya
authors.forename: A
authors.initials: A
authors.lastname: Pandey
mesh_terms: D000083:Acetanilides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy; D005260:Female; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D008297:Male; D051379:Mice; D051381:Rats
chemical_list: D000083:Acetanilides; D001786:Blood Glucose; D007004:Hypoglycemic Agents