Comparative evaluation of the inhibitory activities of the novel penicillanic acid sulfone Ro 48-1220 against beta-lactamases that belong to groups 1, 2b, and 2be.
The inhibitory activity of the penicillanic acid sulfone Ro 48-1220 against group 1, 2b, and 2be beta-lactamases was evaluated. Ro 48-1220 inhibited TEM and SHV as effectively as clavulanate and tazobactam. It also inhibited group 1 beta-lactamases at lower concentrations than tazobactam. Ro 48-1220, at a concentration of 4 micrograms/ml, protected ceftriaxone and ceftazidime against strains producing group 1 and 2be beta-lactamases.
Tzouvelekis
L S
LS
Department of Bacteriology, Hellenic Pasteur Institute, Athens, Greece.
Gazouli
M
M
Prinarakis
E E
EE
Tzelepi
E
E
Legakis
N J
NJ
D001419:Bacteria / Q000187:drug effects* / Q000201:enzymology; D004352:Drug Resistance, Microbial; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases
C105421:Ro 48-1220; D065093:beta-Lactamase Inhibitors; D010397:Penicillanic Acid; C054882:beta-lactamase PIT-2; D001618:beta-Lactamases; C034413:beta-lactamase TEM-1; C056342:beta-lactamase TEM-2