Detection of acute rejection by 133Xe radiospirometry after single lung transplantation in an experimental porcine model.
Aim of this experimental study was to evaluate acute rejection in a porcine single-lung transplantation model by using 133Xe radiospirometry. Left lung allotransplantation was performed on 11 and autotransplantation on 5 piglets. Postoperative monitoring consisted of 77 radiospirometric examinations with assessments of regional perfusion (Qtx), ventilation (V) and ventilation/perfusion ratio (V/Qtx). Results were compared with transbronchial biopsy. A significant decrease in Qtx (p < 0.01) and an increase in V/Qtx (p < 0.01) were observed during acute rejection, whereas V remained unaltered. These changes were significant already at minimal rejection (grade A1), and further increased at moderate rejection (grade A3). Sensitivity and specificity of Qtx were 82 and 74%, and those of V/Qtx, 87 and 65%. 133Xe radiospirometry detects even minimal acute rejection after single lung transplantation.
Ikonen
T
T
Department of Surgery, Helsinki University Central Hospital, Finland.
Sovijärvi
A R
AR
Taskinen
E
E
Uusitalo
M
M
Kivisaari
L
L
Aarnio
P
P
Harjula
A L
AL
D000208:Acute Disease; D000818:Animals; D001706:Biopsy; D004195:Disease Models, Animal; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D016040:Lung Transplantation / Q000502:physiology; D011184:Postoperative Period; D011237:Predictive Value of Tests; D011859:Radiography; D012680:Sensitivity and Specificity; D013147:Spirometry / Q000379:methods*; D013552:Swine; D014692:Ventilation-Perfusion Ratio; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes