title: Helicobacter pylori in kidney allograft recipients: high prevalence of colonization and low incidence of active inflammatory lesions.
abstract: Since kidney transplant recipients are at enhanced risk for developing severe upper gastrointestinal disease and Helicobacter pylori (Hp) is an important pathogen in active gastritis and peptic ulcer, we performed gastroduodenoscopic examination, coupled with assessment of Hp colonization in 29 renal allograft recipients complaining of recurrent dyspepsia. Results were compared with those of 25 chronically hemodialyzed patients and 16 subjects free from renal disease, also suffering from upper gastrointestinal symptoms of similar severity. We found that while transplant recipients have had a high prevalence of Hp infection (62 vs. 34.6% in dialysis and 43.6% in control dyspeptic patients), active gastritis was clearly less frequently seen in these patients than in control subjects (transplant group: 6.9%, dialysis 3.8%, control 31.3%) and peptic ulceration was totally absent. Prevalence of Hp colonization was even higher in renal graft recipients on triple posttransplant immunosuppression (82%). In dyspeptic transplant and dialysis patients, colonization with Hp did not account for development of active inflammatory lesions, an association frequently seen in subjects free from renal disease and immunosuppressive therapy.
authors.affiliation: Department of Nephrology, Wrocław School of Medicine, Poland.
authors.forename: Z
authors.initials: Z
authors.lastname: Hruby
authors.forename: K
authors.initials: K
authors.lastname: Myszka-Bijak
authors.forename: G
authors.initials: G
authors.lastname: Gościniak
authors.forename: J
authors.initials: J
authors.lastname: Błaszczuk
authors.forename: W
authors.initials: W
authors.lastname: Czyz
authors.forename: P
authors.initials: P
authors.lastname: Kowalski
authors.forename: K
authors.initials: K
authors.lastname: Falkiewicz
authors.forename: G
authors.initials: G
authors.lastname: Szymańska
authors.forename: A
authors.initials: A
authors.lastname: Przondo-Mordarska
mesh_terms: D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D001706:Biopsy; D004415:Dyspepsia / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology; D016145:Endoscopy, Digestive System; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology* / Q000473:pathology; D006084:Graft Rejection / Q000517:prevention & control; D016481:Helicobacter Infections / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D016480:Helicobacter pylori / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012008:Recurrence
chemical_list: D000907:Antibodies, Bacterial; D007166:Immunosuppressive Agents