Killing kinetics of meropenem against penicillin-resistant pneumococci.
The killing kinetics of meropenem against sixteen clinical isolates of pneumococci (12 penicillin-resistant, three penicillin-intermediate and one penicillin-sensitive) were studied. Meropenem was tested at 1x, 2x and 4x the MIC for each individual isolate. The results showed a good bactericidal activity with rapid killing of pneumococci (killing > 3 log10 cfu/mL was obtained for nine strains). This strategy needs clinical assessment and might prove to be a suitable alternative to penicillin and cephalosporins for the treatment of mixed infections involving multiresistant pneumococci.
Barakett
V
V
Laboratoire Central de Microbiologie-CHU Saint-Antoine, Paris, France.
Lesage
D
D
Delisle
F
F
Richard
G
G
Petit
J C
JC
D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D013845:Thienamycins / Q000493:pharmacokinetics / Q000494:pharmacology*
D013845:Thienamycins; D000077731:Meropenem