Bcl-x gene expression in Hodgkin's disease.
Bcl-x is a Bcl-2-family protein that has been previously detected in cortical thymocytes, plasma cells, and activated lymphocytes. We report here on the high detection rate of the Bcl-x protein found in 86% of Hodgkin's disease samples and on the significance regarding its complex role among the Bcl-2-family of proteins: Bcl-x is known to heterodimerize with Bcl-2 (an anti-apoptosis protein) and with Bax, a potent inducer of cell death. Moreover, recent evidences show that Bcl-x may induce multiple drug resistance in vitro, suggesting that chemical or biological interactions with this protein may have potential therapeutic value in Hodgkin's disease.
Schlaifer
D
D
Service d'Hématologie, Clinique Dieulafoy, Centre Hospitalier Universitaire, Hôpital de Purpan, Toulouse, France.
Krajewski
S
S
Rigal-Huguet
F
F
Laurent
G
G
Pris
J
J
Delsol
G
G
Reed
J C
JC
Brousset
P
P
D017209:Apoptosis / Q000235:genetics; D002470:Cell Survival / Q000235:genetics; D002883:Chromosomes, Human, Pair 14; D002887:Chromosomes, Human, Pair 18; D003429:Cross Reactions; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006689:Hodgkin Disease / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics*; D014178:Translocation, Genetic; D051020:bcl-X Protein
C494811:BCL2L1 protein, human; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051020:bcl-X Protein