[Participation of inducible stress-proteins in realizing the cardioprotective effect of Rhodiolae rosea].
The effects of the Rhodiolae rosea extract on contractility of rat hearts isolated by the Langendorff's technique, creatine phosphokinase activity in the perfusate, and induction of myocardial stress protein synthesis (hsp-70) were studied after total ischemia and reperfusion. The adaptogen produces cardioprotector effects and prevents ischemia- and reperfusion-induced contractility aberrations. The possible role of inducible stress proteins (hsp-70) in these effects is discussed.
Afanas'ev
S A
SA
Krylatov
A V
AV
Lasukova
T V
TV
Lishmanov
Iu V
IuV
D000818:Animals; D003402:Creatine Kinase / Q000378:metabolism; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis / Q000502:physiology*; D006321:Heart / Q000187:drug effects*; D017202:Myocardial Ischemia / Q000201:enzymology / Q000517:prevention & control; D015428:Myocardial Reperfusion Injury / Q000201:enzymology / Q000517:prevention & control; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D018840:HSP70 Heat-Shock Proteins; D010936:Plant Extracts; D003402:Creatine Kinase