A novel malaria protein, Pfs28, and Pfs25 are genetically linked and synergistic as falciparum malaria transmission-blocking vaccines.
Antibodies to Pfs28 block Plasmodium falciparum transmission and when combined with antibodies to Pfs25 provide synergy in blocking transmission. Pfs28 and Pfs25 are immunogenic, have limited antigenic diversity, and are structurally similar and genetically linked on chromosome 10. Pfs28 may prove a useful addition to Pfs25 in an effective transmission-blocking vaccine.
Duffy
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PE
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-0425, USA.
Kaslow
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DC
D000595:Amino Acid Sequence; D000818:Animals; D000852:Anopheles; D000953:Antigens, Protozoan / Q000235:genetics / Q000276:immunology*; D005260:Female; D008040:Genetic Linkage; D016778:Malaria, Falciparum / Q000517:prevention & control / Q000635:transmission*; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D010963:Plasmodium falciparum / Q000276:immunology*; D015800:Protozoan Proteins / Q000235:genetics / Q000276:immunology*; D016052:Protozoan Vaccines / Q000276:immunology*
D000953:Antigens, Protozoan; C071284:Pfs25 protein, Plasmodium falciparum; D015800:Protozoan Proteins; D016052:Protozoan Vaccines