title: Sonodynamically induced antitumor effect of gallium-porphyrin complex by focused ultrasound on experimental kidney tumor.
abstract: The antitumor effect of a gallium-porphyrin complex, ATX-70, induced by focused ultrasound, on colon 26 carcinoma implanted in a mouse kidney was investigated. Colon 26 tumors were exposed to focused ultrasound at 500 kHz and 1 MHz in a progressive wave mode. Both frequency components were superimposed onto each other in the focal zone to efficiently produce cavitation in the tumor. ATX-70 was administered intravenously at the dose of 2.5 mg/kg, 24 h before the ultrasonic exposure. Antitumor effects were evaluated by histological observation 7 days after the exposure. The destruction of tumor tissue was observed with the ultrasonic treatment in combination with ATX-70, while neither the treatment with ATX-70 alone nor that with ultrasound alone caused any necrosis. These results first demonstrated that antitumor effects of a porphyrin compound can be induced by focused ultrasound in a progressive wave mode.
authors.affiliation: School of Pharmaceutical Science, Toho University, Funabashi, Chiba, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Yumita
authors.forename: K
authors.initials: K
authors.lastname: Sasaki
authors.forename: S
authors.initials: S
authors.lastname: Umemura
authors.forename: A
authors.initials: A
authors.lastname: Yukawa
authors.forename: R
authors.initials: R
authors.lastname: Nishigaki
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D007668:Kidney; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000188:drug therapy / Q000628:therapy*; D011166:Porphyrins / Q000627:therapeutic use*; D014464:Ultrasonic Therapy / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents; D011166:Porphyrins; C081908:ATX 70