title: [Autoimmune hypoglycemia syndrome with specific anti-human insulin antibodies].
abstract: A 33 year old woman with episodes of severe hypoglycemia is presented. The studies showed anti-insulin antibodies and variable C-peptide levels. Circulating insulin measured after acid-ethanol extraction, was of 1,600 uU/ml and shown to be human insulin after characterization by HLPC. Specific anti-human insulin antibodies were of high affinity (Ka1: 6.20 x 10(10) M-1; Ka2: 2.42 x 10(9) M-1). A small cross-reactive porcine and bovine antibody subpopulation was also detected (IgG, light k type chain). Plasmapheresis was undertaken when symptoms were spontaneously declining and turned antibody title negative. Prolonged follow-up showed no relapse of this syndrome.
authors.affiliation: Hospital de Niños Dr Ricardo Gutiérrez, Buenos Aires, Argentina.
authors.forename: J C
authors.initials: JC
authors.lastname: Cresto
authors.forename: J E
authors.initials: JE
authors.lastname: Abdenur
authors.forename: N
authors.initials: N
authors.lastname: Chamoles
authors.forename: P
authors.initials: P
authors.lastname: Bresciani
authors.forename: M
authors.initials: M
authors.lastname: Ruiz
authors.forename: B
authors.initials: B
authors.lastname: Massa
authors.forename: M C
authors.initials: MC
authors.lastname: Camberos
authors.forename: J C
authors.initials: JC
authors.lastname: Basabe
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000276:immunology* / Q000628:therapy; D002846:Chromatography, Affinity; D003429:Cross Reactions; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000276:immunology* / Q000628:therapy; D007328:Insulin / Q000097:blood; D007330:Insulin Antibodies; D010956:Plasmapheresis; D013577:Syndrome
chemical_list: D007328:Insulin; D007330:Insulin Antibodies