[Autoimmune hypoglycemia syndrome with specific anti-human insulin antibodies].
A 33 year old woman with episodes of severe hypoglycemia is presented. The studies showed anti-insulin antibodies and variable C-peptide levels. Circulating insulin measured after acid-ethanol extraction, was of 1,600 uU/ml and shown to be human insulin after characterization by HLPC. Specific anti-human insulin antibodies were of high affinity (Ka1: 6.20 x 10(10) M-1; Ka2: 2.42 x 10(9) M-1). A small cross-reactive porcine and bovine antibody subpopulation was also detected (IgG, light k type chain). Plasmapheresis was undertaken when symptoms were spontaneously declining and turned antibody title negative. Prolonged follow-up showed no relapse of this syndrome.
Cresto
J C
JC
Hospital de Niños Dr Ricardo Gutiérrez, Buenos Aires, Argentina.
Abdenur
J E
JE
Chamoles
N
N
Bresciani
P
P
Ruiz
M
M
Massa
B
B
Camberos
M C
MC
Basabe
J C
JC
D000328:Adult; D001327:Autoimmune Diseases / Q000276:immunology* / Q000628:therapy; D002846:Chromatography, Affinity; D003429:Cross Reactions; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000276:immunology* / Q000628:therapy; D007328:Insulin / Q000097:blood; D007330:Insulin Antibodies; D010956:Plasmapheresis; D013577:Syndrome
D007328:Insulin; D007330:Insulin Antibodies