title: Inhibition of the respiration of multi-drug resistant clinical isolates of Mycobacterium tuberculosis by thioridazine: potential use for initial therapy of freshly diagnosed tuberculosis.
abstract: Chlorpromazine and thioridazine are phenothiazines employed in the treatment of psychosis. These agents inhibited the respiration of clinical isolates of Mycobacterium tuberculosis resistant to streptomycin, rifampin, isoniazid, ethambutol and/or pyrazinamid, all first line drugs. Since any adverse reaction to thioridazine is generally less severe than to chlorpromazine, the possibility is attractive that thioridazine may have a potential in the initial management of patients with newly diagnosed tuberculosis with an as yet undetermined antibiotic susceptibility profile.
authors.affiliation: Department of Pathology and Clinical Laboratories, Bronx-Lebanon Hospital Center, New York, USA.
authors.forename: L
authors.initials: L
authors.lastname: Amaral
authors.forename: J E
authors.initials: JE
authors.lastname: Kristiansen
authors.forename: L S
authors.initials: LS
authors.lastname: Abebe
authors.forename: W
authors.initials: W
authors.lastname: Millett
mesh_terms: D014150:Antipsychotic Agents / Q000494:pharmacology; D000995:Antitubercular Agents / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D013881:Thioridazine / Q000494:pharmacology*; D014376:Tuberculosis / Q000188:drug therapy
chemical_list: D014150:Antipsychotic Agents; D000995:Antitubercular Agents; D013881:Thioridazine; D002746:Chlorpromazine