title: Palliative iodized talc pleurodesis with instillation via tube thoracostomy.
abstract: Pleural effusions are a severe complication of advanced malignant disease. Palliative treatment strategies should be simple and effective. We investigated iodized talc pleurodesis through tube thoracostomy for this purpose. A total of 43 patients received a suspension of 5 g talc with 3 g thymol iodine via chest tube. The procedure was well tolerated without major complications in all cases. Unfortunately, 4 patients died of disease within the 1st month after treatment, so that only 39 patients were evaluable for treatment outcome. Follow-up ranged from 1 to 14 months. The success rate after 3 months was 92.5%. In conclusion, iodized talc pleurodesis is an excellent tool in the palliative management of malignant pleural effusions. Administration via chest tube is sufficient for treatment success.
authors.affiliation: Department of Surgery, University of Cologne, Köln, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Türler
authors.forename: M
authors.initials: M
authors.lastname: Gawenda
authors.forename: M
authors.initials: M
authors.lastname: Walter
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015505:Chest Tubes; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007322:Instillation, Drug; D017613:Iodine Compounds / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D016066:Pleural Effusion, Malignant / Q000628:therapy; D018700:Pleurodesis; D015996:Survival Rate; D013627:Talc / Q000008:administration & dosage*; D013907:Thoracostomy / Q000295:instrumentation* / Q000379:methods; D013943:Thymol / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D017613:Iodine Compounds; D013627:Talc; D013943:Thymol