In vivo inhibition of the regenerative capacity of hydatid material after treatment with netobimin.
The effect of netobimin and netobimin plus fenbendazole administration on secondary hydatid disease was studied. Secondary hydatid disease in gerbils (Meriones unguiculatus) was produced by intraperitoneal inoculation of protoscolices of Echinococcus granulosus. The experimental animals received doses of 20 and 50 mg/kg of netobimin or a mixture of netobimin and 1.7 mg/kg of fenbendazole. The results showed that after a single dose of netobimin at the studied concentrations, the cystic material transplanted into the mouse produced a significant recurrence of the disease, but the most remarkable finding was that the hydatid-cyst recurrence never took place when netobimin was given together with fenbendazole.
García-Llamazares
J L
JL
Department of Physiology, Pharmacology and Toxicology, Faculty of Veterinary, University of León, Spain.
Alvarez-de-Felipe
A I
AI
Redondo-Cardeña
P
P
Voces-Alonso
J A
JA
Prieto-Fernández
J G
JG
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D004443:Echinococcosis / Q000473:pathology / Q000517:prevention & control* / Q000635:transmission; D004446:Echinococcus / Q000187:drug effects / Q000254:growth & development*; D005243:Feces / Q000469:parasitology; D005273:Fenbendazole / Q000494:pharmacology*; D005849:Gerbillinae; D006146:Guanidines / Q000494:pharmacology*; D051379:Mice; D012008:Recurrence; D012756:Sheep
D000871:Anthelmintics; D006146:Guanidines; D005273:Fenbendazole; C049626:netobimin