Activity of juvenile hormone and juvenile hormone analogues on the growth of Trypanosoma cruzi.
The effects of juvenile hormone-III (JH-III) and the juvenile hormone analogues (JHA) methoprene and fenoxycarb on the growth and macromolecular biosynthesis in Trypanosoma cruzi were studied in vitro. It was observed that JH-III and JHA blocked growth and 3H-thymidine incorporation without killing the cells within certain concentrations (< or = 1 x 10(-4) M), but they caused cellular death at concentrations over 1 x 10(-3) M. The inhibitory effect on growth was partially reversible. On the other hand, the inhibitory action of JH-III, methoprene and fenoxycarb was an unspecific effect according to the results obtained with Leishmania mexicana mexicana (promastigotes) and human peripheral blood lymphocytes. The JHA have a good possibility of being used in the control of trypanosomiasis.
Stoka
A M
AM
Instituto Nacional de Diagnóstico e Investigación de la Enfermedad deChagas (INDIECH), Buenos Aires, Argentina.
D000818:Animals; D002219:Carbamates / Q000494:pharmacology*; D016054:DNA, Protozoan / Q000096:biosynthesis / Q000187:drug effects; D006801:Humans; D007306:Insecticides / Q000494:pharmacology; D007605:Juvenile Hormones / Q000494:pharmacology*; D007894:Leishmania mexicana / Q000187:drug effects* / Q000378:metabolism; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism / Q000469:parasitology; D008726:Methoprene / Q000494:pharmacology*; D048448:Phenylcarbamates; D014176:Protein Biosynthesis; D011498:Protein Precursors / Q000187:drug effects / Q000378:metabolism; D011506:Proteins / Q000187:drug effects; D012322:RNA Precursors / Q000187:drug effects / Q000378:metabolism; D016053:RNA, Protozoan / Q000096:biosynthesis / Q000187:drug effects; D013936:Thymidine / Q000378:metabolism; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000254:growth & development
D002219:Carbamates; D016054:DNA, Protozoan; D007306:Insecticides; D007605:Juvenile Hormones; D048448:Phenylcarbamates; D011498:Protein Precursors; D011506:Proteins; D012322:RNA Precursors; D016053:RNA, Protozoan; D008726:Methoprene; C052034:fenoxycarb; D013936:Thymidine