title: [The optimization of the infusion therapy procedure in patients with acute leukemias].
abstract: In a trial of 202 patients with acute leukemia (AL) the authors studied the effect of volume and quality of infusion therapy (forced diuresis 2.5 l/m, parenteral nutrition, hemocomponent therapy) on early mortality, frequency of complications, complete remission, overall and relapse-free survival. It is shown that the response in remission induction depends on the scope and quality of infusion therapy. Balanced complete infusion therapy led to a complete remission in 75% and 92% of patients with acute nonlymphoblastic and acute lymphoblastic leukemia, respectively, compared to 29 and 50% for infusion-untreated patients. Early lethality was 6 and 0%, 42 and 18%, respectively. Higher efficacy of acute leukemia treatment in adjuvant balanced infusion therapy results from lower toxicity of chemotherapy and possible performance of induction therapy without reduction of drug doses.
authors.forename: S I
authors.initials: SI
authors.lastname: Moiseev
authors.forename: K M
authors.initials: KM
authors.lastname: Abdulkadyrov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007262:Infusions, Intravenous / Q000379:methods; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D011379:Prognosis; D012074:Remission Induction; D013997:Time Factors