Effects of calcisorb on fecal bile acids and fatty acids in human volunteers.
The intake of calcium (Ca) is negatively associated with colorectal cancer (crc) risk. The aim of this study was to investigate in a double-blind, placebo-controlled trial, the effects of the Ca-binder Calcisorb, which is given to kidney stone patients with hypercalciuria type I, on risk factors for crc risk, bile acids (BA), and long-chain fatty acids (LCFA) in fecal water. Results show that the concentration of BA and LCFA in fecal water did not change, although the urinary excretion of Ca and magnesium (Mg) and the concentration of Ca and magnesium in fecal water decreased. The daily excretion of BA and LCFA acids decreased significantly (p < 0.05) during the Calcisorb period. In conclusion, binding dietary Ca and Mg with Calcisorb from a diet with a relatively low amount of fat does not enhance the solubility of BA and LCFA in fecal water.
van Faassen
A
A
Department of Urology, University Hospital Maastricht, The Netherlands.
van den Bogaard
A E
AE
Hazen
M J
MJ
Geerlings
P
P
Hermus
R J
RJ
Janknegt
R A
RA
D000328:Adult; D001647:Bile Acids and Salts / Q000032:analysis*; D002118:Calcium / Q000652:urine; D002482:Cellulose / Q000031:analogs & derivatives* / Q000494:pharmacology; D004311:Double-Blind Method; D005227:Fatty Acids / Q000032:analysis*; D005243:Feces / Q000737:chemistry*; D006801:Humans; D008274:Magnesium / Q000652:urine; D008297:Male; D012016:Reference Values; D012307:Risk Factors
D001647:Bile Acids and Salts; D005227:Fatty Acids; D002482:Cellulose; C008881:phosphocellulose; D008274:Magnesium; D002118:Calcium