title: Alternative approach for management of infected aortic grafts.
abstract: OBJECTIVE
  Prosthetic infection after aortic reconstructive surgery historically has been treated with extraanatomical bypass, graft excision, and aortic stump closure, but at the cost of substantial mortality and amputation rates. Alternatives to this strategy include in situ prosthetic replacement in the infected area, as well as autogenous reconstructions. Inherent to all of these procedures, however, is either the creation of an aortic stump, which carries a significant risk of subsequent blowout, or the placement of a bypass conduit in the infected field, thereby maintaining the potential for subsequent infectious complications. To avoid such problems, we have used retroperitoneal in-line aortic bypass with polytetrafluoroethylene through dean tissue planes.
  
  
  METHODS
  Since 1987 we have treated 16 graft infections in this manner. The surgical approach consisted of obtaining retroperitoneal proximal aortic control outside of the infected field (above or below the renal arteries), followed by infrarenal division and oversewing of the distal aorta. A polytetrafluoroethylene bifurcated graft was then sewn to the proximal aorta and tunnelled through the psoas sheath laterally to the profunda femoris artery on the ipsilateral side and via the space of Retzius to the contralateral appropriate femoral vessel, so as to avoid any contact with the infected areas. After the closure of the wounds, a plastic barrier was placed over all incisions and the patient was placed supine. The old infected graft was removed transperitoneally. Extensive cultures were taken at various sites to demonstrate no cross-contamination.
  
  
  RESULTS
  All patients were followed-up clinically and with tagged white cell scans at 6-month intervals. There were no immediate postoperative deaths and no amputations. One patient had a myocardial infarction and died at 5 months, and a second patient died at 2 months. Of the remaining 14 patients, none had recurrent sepsis and all have had negative Indium-labeled white cell scans in follow-up. Eleven (78%) are still alive, with a mean follow-up of 32 months (range, 20 to 106 months).
  
  
  CONCLUSIONS
  In-line aortic bypass for treatment of aortic graft infections yields excellent results and has become our treatment of choice in dealing with this difficult problem.
authors.affiliation: Section of Vascular Surgery, Albany Medical College, NY 12208, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Darling
authors.forename: M
authors.initials: M
authors.lastname: Resnikoff
authors.forename: P B
authors.initials: PB
authors.lastname: Kreienberg
authors.forename: B B
authors.initials: BB
authors.lastname: Chang
authors.forename: P S
authors.initials: PS
authors.lastname: Paty
authors.forename: R P
authors.initials: RP
authors.lastname: Leather
authors.forename: D M
authors.initials: DM
authors.lastname: Shah
mesh_terms: D000368:Aged; D001011:Aorta / Q000601:surgery*; D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011138:Polytetrafluoroethylene; D016459:Prosthesis-Related Infections / Q000209:etiology / Q000601:surgery*; D012086:Reoperation; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D011138:Polytetrafluoroethylene