Evaluation of some acylamide derivatives as potential hypoglycemic agents.
A series of new acylamide derivatives with piperidine, pyrrolidinyl and alanyl have been tested for their hypoglycemic activities. 2-(Pyrrolidynyl)-N-(3-chlorophenyl) acetamide and 2-(Piperazinyl)-N-(4-methoxy phenyl) acetamide were found most active hypoglycemic compounds. Probably the amides have mode of action similar to sulphonylureas.
Srivastava
V
V
Dept. of Pharmaceutics, I.T., Varanasi, India.
Suresh
A J
AJ
Pandeya
S N
SN
Pandey
A
A
D000083:Acetanilides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy; D005260:Female; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D008297:Male; D051379:Mice; D051381:Rats
D000083:Acetanilides; D001786:Blood Glucose; D007004:Hypoglycemic Agents