title: [Liver transplantation in an adolescent with cystic fibrosis].
abstract: BACKGROUND
  Orthotopic liver transplantation (OLT) is an effective treatment for patients with cystic fibrosis end stage liver disease, especially those with only mild pulmonary involvement. Long-term follow-up in such transplanted patients is still lacking.
  
  
  METHODS
  A 15-year-old girl with cystic fibrosis received an OLT because of severe decompensated cirrhosis. She had been colonized by Pseudomonas aeruginosa for 3 years and had pancreatic insufficiency; she also had mild glucose intolerance. Postoperatively she developed diabetes mellitus requiring insulin therapy for 9 months. Oral cyclosporin was poorly absorbed so that she was given a new emulsion of cyclosporin (Neoral) that was better absorbed. A rapid pubertal catch-up was obtained but the patient remained colonized by Pseudomonas aeruginosa.
  
  
  CONCLUSIONS
  This 3-year postoperative follow-up confirms that OLT can represent a good alternative in those patients with severe liver disease and mild pulmonary involvement.
authors.affiliation: Service de pédiatrie, CHRU, hôpital Claude-Huriez, Lille, France.
authors.forename: P
authors.initials: P
authors.lastname: Thevenot
authors.forename: F
authors.initials: F
authors.lastname: Gottrand
authors.forename: E
authors.initials: E
authors.lastname: Tassin
authors.forename: V
authors.initials: V
authors.lastname: Launay
authors.forename: G A
authors.initials: GA
authors.lastname: Loeuille
authors.forename: M
authors.initials: M
authors.lastname: Razemon
authors.forename: D
authors.initials: D
authors.lastname: Turck
authors.forename: M
authors.initials: M
authors.lastname: Bonnevalle
authors.forename: F R
authors.initials: FR
authors.lastname: Pruvot
authors.forename: V
authors.initials: V
authors.lastname: Hue
authors.forename: J P
authors.initials: JP
authors.lastname: Farriaux
mesh_terms: D000293:Adolescent; D001824:Body Constitution; D003550:Cystic Fibrosis / Q000150:complications / Q000628:therapy*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000601:surgery; D016031:Liver Transplantation; D011184:Postoperative Period