The effect of ethanol upon early development in mice and rats. XXIII. The effect of indomethacin on beer-induced disturbances of preimplantation development in rats.
The effect of Indomethacin on beer-induced modifications of preimplantation development was investigated in rats (control on day 5 of pregnancy), using the following criteria: the mean number of embryos/animal, topographical distribution of embryos, the developmental stage attained, the appearance of pathological forms, the mean cell number/embryo. It resulted that previous administration of Indomethacin antagonized the main deleterious effect of repeated acute administration of beer in the preimplantation period, supporting the hypothesis of prostaglandins (PG) being involved in the pathogenetic action of this alcoholic beverage.
Fazakas-Todea
I
I
Laboratory of Embryology and Teratology, Center of Medicine and for Sanitary Services and Management, Timişoara, Romania.
Checiu
M
M
D000818:Animals; D001515:Beer / Q000633:toxicity*; D001755:Blastocyst / Q000187:drug effects* / Q000201:enzymology; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D000431:Ethanol / Q000037:antagonists & inhibitors / Q000633:toxicity*; D005260:Female; D007213:Indomethacin / Q000494:pharmacology*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
D016861:Cyclooxygenase Inhibitors; D000431:Ethanol; D007213:Indomethacin