Micronuclei-induction and its correlation to cell survival in HeLa cells treated with different doses of adriamycin.
The treatment of HeLa cells with different concentrations of adriamycin (0, 5, 10, 25, 50 and 100 microg/ml) resulted in a significant and dose-dependent decline in the cell survival. Conversely, the frequency of micronuclei increased in a concentration-dependent manner. The micronuclei-induction and cell survival were found to be inversely related.
Jagetia
G C
GC
Department of Radiobiology, Kasturba Medical College, Manipal, India.
Nayak
V
V
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage / Q000494:pharmacology*; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D015162:Micronucleus Tests
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin