Occurrence of myeloma in a chronic lymphocytic leukemia patients after response to differentiation therapy with interleukin-4.
The occurrence of chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) in a single individual is rare, and the clonal relationship between the two neoplasms is unclear. We describe here a patient with CLL who developed symptoms of MM while responding to experimental therapy with interleukin-4 (IL-4). This patient was treated with 2-chlorodeoxyadenosine (2-CDA), and had a response in both malignancies.
Makower
D
D
Department of Oncology, Albert Einstein Cancer Center, Bronx, New York, USA.
Venkatraj
U
U
Dutcher
J P
JP
Wiernik
P H
PH
D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D002454:Cell Differentiation / Q000187:drug effects; D017338:Cladribine / Q000627:therapeutic use; D006801:Humans; D015847:Interleukin-4 / Q000009:adverse effects* / Q000627:therapeutic use*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000188:drug therapy*
D000970:Antineoplastic Agents; D015847:Interleukin-4; D017338:Cladribine