title: Are there ethnic differences in deletions in the dystrophin gene?
abstract: We studied 160 cases of Duchenne muscular dystrophy (DMD) drawn from all parts of India, using multiplex PCR of 27 exons. Of these, 103 (64.4%) showed intragenic deletions. Most (69.7%) of the deletions involved exons 45-51. The phenotype of cases with deletion of single exons did not differ significantly from those with deletion of multiple exons. The distribution of deletions in studies from different countries was variable, but this was accounted for either by the small number of cases studied, or by fewer exons analyzed. It is concluded that there is likely to be no ethnic difference with respect to deletions in the DMD gene.
authors.affiliation: Department of Pediatrics, World Health Organization Collaborating Centre in Genetics, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: M
authors.initials: M
authors.lastname: Banerjee
authors.forename: I C
authors.initials: IC
authors.lastname: Verma
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D017931:DNA Primers / Q000235:genetics; D016189:Dystrophin / Q000235:genetics*; D004587:Electrophoresis, Agar Gel; D005091:Exons; D006801:Humans; D007194:India / Q000453:epidemiology / Q000208:ethnology; D008297:Male; D017720:Molecular Epidemiology; D009136:Muscular Dystrophies / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D017384:Sequence Deletion / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
chemical_list: D017931:DNA Primers; D016189:Dystrophin