Effects of opioid-type stressors on serum digoxin-like immunoreactivity in rats.
The effects of opioid-type stressors (immobilization, electric footshock and forced swimming) on serum digoxin-like immunoreactivity (SDLI) were investigated in rats. All of the stressors significantly elevated the SDLI. Naloxone treatment after application of stressors prevented the elevation of SDLI, whereas naloxone treatment alone did not cause any significant changes. The observed increase in SDLI in this study may be attributed to the actions of endogenous opioid peptides released during stress.
Uresin
Y
Y
Department of Pharmacology and Clinical Pharmacology, Istanbul University Medical Faculty, Turkey.
Eroglu
L
L
Yildiran
G
G
D000818:Animals; D002298:Cardenolides; D004077:Digoxin; D004597:Electroshock; D004791:Enzyme Inhibitors / Q000097:blood*; D007103:Immobilization; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D005082:Physical Exertion; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000097:blood*; D013312:Stress, Physiological / Q000378:metabolism*
D002298:Cardenolides; D004791:Enzyme Inhibitors; D009292:Narcotic Antagonists; D012503:Saponins; C034504:digoxin-like factors; D009270:Naloxone; D004077:Digoxin