Synthetic peptides derived from human MHC class I sequences delay allograft rejection in rodents and inhibit cell-mediated cytotoxicity in vivo and in vitro.
Cuturi
M C
MC
Institut de Transplantation et de Recherche en Transplantation (ITERT), INSERM Unit, Nantes, France.
Josien
R
R
Douillard
P
P
Giral
M
M
Soulillou
J P
JP
D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control*; D015235:HLA-B Antigens / Q000737:chemistry / Q000494:pharmacology; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007111:Immunity, Cellular; D007166:Immunosuppressive Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology*; D012377:Rodentia; D014184:Transplantation, Homologous / Q000276:immunology
D015235:HLA-B Antigens; D015395:Histocompatibility Antigens Class I; D007166:Immunosuppressive Agents; D010455:Peptides