A polysaccharide-peptide complex from cultured mycelia of the mushroom Tricholoma mongolicum with immunoenhancing and antitumor activities.
A polysaccharide-peptide complex with immunoenhancing and antitumor activities was obtained from the mycelial culture of Tricholoma mongolicum, an edible mushroom found in Northern China. The polysaccharide-peptide complex had a molecular mass of 15.5 kDa, as estimated by gel filtration, and a carbohydrate-protein ratio of about 8:1 and was not adsorbed on DEAE-Sepharose CL-6B. It possessed the activities of activating macrophages, stimulating macrophage antigen-presenting activity, which in turn enhanced proliferation of T-cells, and inhibiting the growth of sarcoma 180 cells that had been implanted in mice.
Wang
H X
HX
Department of Biology, Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
Ng
T B
TB
Ooi
V E
VE
Liu
W K
WK
Chang
S T
ST
D000276:Adjuvants, Immunologic / Q000302:isolation & purification / Q000627:therapeutic use*; D000364:Agaricus / Q000276:immunology*; D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D016215:Macrophage-Activating Factors / Q000096:biosynthesis; D017737:Macrophages, Peritoneal / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008934:Mitogens / Q000494:pharmacology; D009573:Nitrites / Q000378:metabolism; D010455:Peptides / Q000494:pharmacology*; D011134:Polysaccharides / Q000494:pharmacology*; D012510:Sarcoma 180 / Q000188:drug therapy / Q000473:pathology; D013601:T-Lymphocytes / Q000187:drug effects; D014407:Tumor Cells, Cultured
D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D016215:Macrophage-Activating Factors; D008934:Mitogens; D009573:Nitrites; D010455:Peptides; D011134:Polysaccharides