title: In search of virulence factors of human bacterial disease.
abstract: Traditional genetic techniques and a variety of animal and tissue-culture model systems have sustained the study of bacterial virulence mechanisms for several decades. However, the recent application of newly developed molecular and cellular techniques has brought our understanding of bacterial pathogenesis to new heights by permitting the identification and analysis of previously unknown constitutively and differentially expressed virulence-associated factors.
authors.affiliation: Divn of AIDS, STD and TB Laboratory Research, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. fdq1@ciddas1.em.cdc.gov
authors.forename: F D
authors.initials: FD
authors.lastname: Quinn
authors.forename: G W
authors.initials: GW
authors.lastname: Newman
authors.forename: C H
authors.initials: CH
authors.lastname: King
mesh_terms: D001419:Bacteria / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000235:genetics / Q000276:immunology / Q000382:microbiology*; D018929:Cell Culture Techniques / Q000379:methods; D003001:Cloning, Molecular; D004591:Electrophoresis, Polyacrylamide Gel; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial / Q000502:physiology; D006801:Humans; D008967:Molecular Biology / Q000379:methods*; D016296:Mutagenesis; D009693:Nucleic Acid Hybridization / Q000379:methods; D016133:Polymerase Chain Reaction / Q000379:methods; D014774:Virulence / Q000235:genetics / Q000276:immunology