Xbap, a vertebrate gene related to bagpipe, is expressed in developing craniofacial structures and in anterior gut muscle.
The Drosophila bagpipe (bap) gene is involved in the specification of the musculature of the embryonic midgut. We report the isolation and characterization of a Xenopus sequence, Xbap, which is closely related to bap. Xbap is also expressed in the developing musculature of the midgut, suggesting that this developmental role of bagpipe is evolutionarily conserved. However, a second, novel role in development is suggested by the observation that Xbap is also expressed in a region of the developing facial cartilage. Using a combination of cartilage staining and comparison to the goosecoid head expression pattern, we show that Xbap expression marks the precursors to the basihyobranchial, palatoquadrate, and possibly Meckel's cartilages. This vertebrate bagpipe sequence therefore is expressed in both mesodermally and neural crest-derived tissues.
Newman
C S
CS
Center for Developmental Biology, Department of Zoology, University of Texas at Austin, 78712, USA.
Grow
M W
MW
Cleaver
O
O
Chia
F
F
Krieg
P
P
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002356:Cartilage / Q000196:embryology* / Q000378:metabolism; D018076:DNA, Complementary / Q000235:genetics; D004268:DNA-Binding Proteins / Q000096:biosynthesis; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics*; D019143:Evolution, Molecular; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox; D051956:Goosecoid Protein; D006257:Head / Q000196:embryology; D006321:Heart / Q000196:embryology; D018398:Homeodomain Proteins / Q000096:biosynthesis / Q000235:genetics*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000196:embryology*; D007568:Jaw / Q000196:embryology; D008969:Molecular Sequence Data; D009130:Muscle, Smooth / Q000196:embryology* / Q000378:metabolism; D009432:Neural Crest / Q000378:metabolism; D012097:Repressor Proteins; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012886:Skull / Q000196:embryology* / Q000378:metabolism; D013045:Species Specificity; D014157:Transcription Factors; D029867:Xenopus Proteins; D014982:Xenopus laevis / Q000235:genetics*; D015027:Zebrafish / Q000235:genetics
D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D051956:Goosecoid Protein; D018398:Homeodomain Proteins; C104164:NKX3-2 protein, Xenopus; D012097:Repressor Proteins; D014157:Transcription Factors; D029867:Xenopus Proteins; C104163:bagpipe protein, Drosophila