title: Sarcoma of bone-cement membrane: a case report and review of the literature.
abstract: The development of a cancerous tumour at the site of total joint replacement is a rare but virtually always fatal event. The previously unreported scenario of a patient who was found to have a malignant fibrous histocytoma at the bone-cement membrane after revision for a loose total hip prosthesis is reported. Recent biologic information evaluating the response of mesenchymal cells to metallic debris suggests that the environment surrounding a loosened prosthesis may provide conditions appropriate for the development of a sarcoma.
authors.affiliation: Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Ont.
authors.forename: R S
authors.initials: RS
authors.lastname: Bell
authors.forename: S
authors.initials: S
authors.lastname: Hopyan
authors.forename: A M
authors.initials: AM
authors.lastname: Davis
authors.forename: R
authors.initials: R
authors.lastname: Kandel
authors.forename: A E
authors.initials: AE
authors.lastname: Gross
mesh_terms: D001707:Biopsy, Needle; D001843:Bone Cements; D002858:Chromium Alloys; D017809:Fatal Outcome; D005260:Female; D005266:Femoral Neoplasms / Q000175:diagnosis / Q000209:etiology*; D006618:Hip Dislocation, Congenital / Q000150:complications / Q000601:surgery; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D020366:Methylmethacrylate; D008768:Methylmethacrylates; D008875:Middle Aged; D009367:Neoplasm Staging; D015207:Osteoarthritis, Hip / Q000209:etiology / Q000601:surgery; D011095:Polyethylenes; D011475:Prosthesis Failure; D012509:Sarcoma / Q000209:etiology*
chemical_list: D001843:Bone Cements; D002858:Chromium Alloys; D008768:Methylmethacrylates; D011095:Polyethylenes; D020366:Methylmethacrylate