title: Control of cell cycle arrest by the Mec1sc/Rad3sp DNA structure checkpoint pathway.
abstract: The Mec1(sc)/Rad3(sp) protein family is central to the checkpoint pathways of cells. Functions upstream and downstream of Mec1(sc)/Rad3(sp) show both similarities and differences when compared between organisms. Analogy with a related protein, DNAPKcs, suggests that different subunits may activate Mec1(sc)/Rad3(sp) in response to specific DNA or DNA-protein structures.
authors.affiliation: MRC Cell Mutation Unit, Sussex University, Falmer BN1 9RR UK. a.m. carr@sussex.ac.uk
authors.forename: A M
authors.initials: AM
authors.lastname: Carr
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D002453:Cell Cycle / Q000502:physiology*; D004265:DNA Helicases / Q000378:metabolism*; D004271:DNA, Fungal / Q000378:metabolism*; D005656:Fungal Proteins / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins; D017346:Protein Serine-Threonine Kinases; D029701:Saccharomyces cerevisiae Proteins
chemical_list: D004271:DNA, Fungal; D005656:Fungal Proteins; D047908:Intracellular Signaling Peptides and Proteins; D029701:Saccharomyces cerevisiae Proteins; C088937:MEC1 protein, S cerevisiae; D017346:Protein Serine-Threonine Kinases; D000251:Adenosine Triphosphatases; C061897:Rad3 protein, S cerevisiae; D004265:DNA Helicases