In vitro drug adsorption to charcoal, silicas, acrylate copolymer and silicone oil with charcoal and with acrylate copolymer.
1. The relative binding constants of four drugs to charcoal, silicone oil silicas and acrylate copolymers was studied using an in-vitro binding technique. 2. The maximum adsorption capacity (K2) was chosen as a measure of the degree of binding and calculated by fitting to the Langmuir equation. 3. Charcoal alone was shown to be the most effective of the adsorbents chosen. The possible use of silicone oils as an adsorbent delivery vehicle in treatment of overdose is discussed.
Cassidy
S L
SL
Dow Corning, Health Environmental and Regulatory Affairs, Barry, South Glamorgan.
Hale
A
A
Buss
D C
DC
Routledge
P A
PA
D000082:Acetaminophen / Q000737:chemistry; D000179:Acrylates / Q000737:chemistry*; D000327:Adsorption; D000983:Antipyrine / Q000737:chemistry; D001665:Binding Sites; D002606:Charcoal / Q000737:chemistry*; D008787:Metoclopramide / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D012827:Silicone Oils / Q000737:chemistry*; D014859:Warfarin / Q000737:chemistry
D000179:Acrylates; D004364:Pharmaceutical Preparations; D012827:Silicone Oils; D002606:Charcoal; D000082:Acetaminophen; D014859:Warfarin; D012822:Silicon Dioxide; D008787:Metoclopramide; D000983:Antipyrine