The role of B7-1/B7-2:CD28/CLTA-4 pathways in the prevention of anergy, induction of productive immunity and down-regulation of the immune response.
Boussiotis
V A
VA
Division of Hematologic Malignancies, Dana Farber Cancer Institute, Boston, MA 02115, USA.
Freeman
G J
GJ
Gribben
J G
JG
Nadler
L M
LM
D000069594:Abatacept; D015703:Antigens, CD / Q000378:metabolism*; D000943:Antigens, Differentiation / Q000378:metabolism*; D018122:B7-1 Antigen; D051940:B7-2 Antigen; D018106:CD28 Antigens; D060908:CTLA-4 Antigen; D017635:Clonal Anergy / Q000502:physiology; D015536:Down-Regulation; D005786:Gene Expression Regulation; D007108:Immune Tolerance / Q000502:physiology*; D018796:Immunoconjugates; D007166:Immunosuppressive Agents / Q000378:metabolism*; D008213:Lymphocyte Activation; D008562:Membrane Glycoproteins; D011948:Receptors, Antigen, T-Cell; D015398:Signal Transduction
D015703:Antigens, CD; D000943:Antigens, Differentiation; D018122:B7-1 Antigen; D051940:B7-2 Antigen; D018106:CD28 Antigens; D060908:CTLA-4 Antigen; D018796:Immunoconjugates; D007166:Immunosuppressive Agents; D008562:Membrane Glycoproteins; D011948:Receptors, Antigen, T-Cell; D000069594:Abatacept