title: Hb S/Hb Lepore with mild sickling symptoms: a hemoglobin variant with mostly delta-chain sequences ameliorates sickle-cell disease.
abstract: Three cases are reported of Hb S/Hb Lepore combination with very mild sickling manifestations. The presence of a nonalpha-chain variant with a high proportion of delta chain sequences, including 22 ala, appears to ameliorate sickle-cell disease. Efforts to increase the proportion of Hb A2 may be beneficial in sickle-cell disease.
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: V F
authors.initials: VF
authors.lastname: Fairbanks
authors.forename: D J
authors.initials: DJ
authors.lastname: McCormick
authors.forename: K S
authors.initials: KS
authors.lastname: Kubik
authors.forename: W N
authors.initials: WN
authors.lastname: Rezuke
authors.forename: D
authors.initials: D
authors.lastname: Black
authors.forename: M S
authors.initials: MS
authors.lastname: Ochaney
authors.forename: D
authors.initials: D
authors.lastname: Schwartz
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000503:physiopathology*; D005260:Female; D014644:Genetic Variation; D006451:Hemoglobin, Sickle / Q000032:analysis*; D006454:Hemoglobins / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006801:Humans; D008297:Male
chemical_list: D006451:Hemoglobin, Sickle; D006454:Hemoglobins; D006455:Hemoglobins, Abnormal; C037659:hemoglobin Lepore