title: The morphology of the immature HIV-1 virion.
abstract: Newly released HIV-1 particles exhibit an immature morphology, previously reported to be characterized by a doughnut/ring-shaped structure. In this study we showed that among immature extracellular virus particles not only were particles with doughnut-shaped morphology present, but particles with a crescent morphology were also observed. These particles occurred with different frequencies, depending on whether they were in the cell or in cell-free fractions. The crescent-shaped particles were more abundant in the cell-free fractions, whereas the particles in the cell fraction mainly exhibited doughnut-shaped morphology. The crescent-shaped structure may represent an assembly intermediate.
authors.affiliation: Department of Biochemistry, Biomedical Center, Uppsala, Sweden. asa@totem.bm-c.uu.se
authors.forename: A
authors.initials: A
authors.lastname: Ohagen
authors.forename: R B
authors.initials: RB
authors.lastname: Luftig
authors.forename: A S
authors.initials: AS
authors.lastname: Reicin
authors.forename: L
authors.initials: L
authors.lastname: Yin
authors.forename: K
authors.initials: K
authors.lastname: Ikuta
authors.forename: T
authors.initials: T
authors.lastname: Kimura
authors.forename: S P
authors.initials: SP
authors.lastname: Goff
authors.forename: S
authors.initials: S
authors.lastname: Höglund
mesh_terms: D002461:Cell Line, Transformed; D015497:HIV-1 / Q000648:ultrastructure*; D006801:Humans; D014771:Virion / Q000648:ultrastructure