title: Effectiveness of bacillus of Calmette-Guerin (BCG) vaccination against tuberculous meningitis: a case-control study.
abstract: A hospital-based pair-matched case-control study was carried out at Government Medical College Hospital, Nagpur to estimate the effectiveness of bacillus of Calmette-Guerin (BCG) vaccination against tuberculous meningitis. The study included 92 cases of tuberculous meningitis in the age group of 0-12 years and equal number of controls, matched for age, sex and socio-economic status. The protective effectiveness and prevented fraction were higher for the subjects in the age group of 0-6 years, males and subjects from upper strata of socio-economic class. The overall vaccine effectiveness and prevented fraction were estimated to be 86.54% (70.38-93.88%) and 65.54% (39.22-80.64%) respectively. Results of this study thus indicated that BCG vaccination was highly effective against tuberculous meningitis and played significant role in its prevention, in this population.
authors.affiliation: Government Medical College, Nagpur.
authors.forename: S P
authors.initials: SP
authors.lastname: Zodpey
authors.forename: B R
authors.initials: BR
authors.lastname: Maldhure
authors.forename: S N
authors.initials: SN
authors.lastname: Shrikhande
authors.forename: R R
authors.initials: RR
authors.lastname: Tiwari
mesh_terms: D000367:Age Factors; D001500:BCG Vaccine / Q000627:therapeutic use*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012959:Socioeconomic Factors; D014390:Tuberculosis, Meningeal / Q000628:therapy*
chemical_list: D001500:BCG Vaccine