title: Asymptomatic carotid endarterectomy. Patient and surgeon selection.
abstract: OBJECTIVE
  The applicability of prospective carotid endarterectomy protocols to the general population has been questioned. Outcomes for asymptomatic patients undergoing carotid endarterectomy were compared with the results of the Asymptomatic Carotid Atherosclerosis Study (ACAS) patients treated concurrently at our institution.
  
  
  METHODS
  Asymptomatic patients undergoing carotid endarterectomies (n = 277) from 1987 to 1993 (ACAS enrollment period) were reviewed. Primary end points were mortality, myocardial infarction, and stroke. Five subgroups were studied: (1) ACAS surgical patients; (2) ACAS-eligible patients not enrolled and ACAS surgeons; (3) ACAS-eligible patients not enrolled and non-ACAS surgeons; (4) ACAS-ineligible patients and ACAS surgeons; and (5) ACAS-ineligible patients and non-ACAS surgeons.
  
  
  RESULTS
  ACAS-eligible patients were younger (P = .014), had more severe carotid stenosis (P = .001), and had lower incidences of pulmonary (P = .015) and renal (P = .008) diseases compared with ineligible patients. Patient selection (ACAS eligibility) significantly improved outcomes for mortality (P = .014) and myocardial infarction (P = .006). Length of stay favored ACAS-eligible patients (P = .004). ACAS surgeons operated on more severely stenotic carotid lesions (P = .005) and on patients with a lower incidence of coronary artery disease (P = .007). There was no difference in outcomes between ACAS and non-ACAS surgeons.
  
  
  CONCLUSIONS
  Patient selection was a significant factor in determining outcome. With strict adherence to ACAS enrollment guidelines, the conclusions of ACAS appear applicable to patients seen at our institution with asymptomatic carotid stenosis.
authors.affiliation: Department of Surgery, Lehigh Valley Hospital, Allentown, PA 18105-1556, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Marcinczyk
authors.forename: G G
authors.initials: GG
authors.lastname: Nicholas
authors.forename: J F
authors.initials: JF
authors.lastname: Reed
authors.forename: S A
authors.initials: SA
authors.lastname: Nastasee
mesh_terms: D000328:Adult; D000368:Aged; D002561:Cerebrovascular Disorders / Q000453:epidemiology / Q000517:prevention & control; D002985:Clinical Protocols; D003327:Coronary Disease / Q000150:complications / Q000601:surgery*; D016894:Endarterectomy, Carotid / Q000401:mortality / Q000592:standards / Q000706:statistics & numerical data; D005260:Female; D013502:General Surgery; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic / Q000592:standards; D009203:Myocardial Infarction / Q000453:epidemiology / Q000517:prevention & control; D018579:Patient Selection; D010414:Pennsylvania; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic / Q000592:standards; D016896:Treatment Outcome