[A study of autonomic innervation of the atrial septum by iso-integral mapping in dogs].
Although neuronal cell bodies have been identified in the upper part of the atrial septum, the functional anatomy of its autonomic innervation remains unknown. To study parasympathetic inputs to the atrial septum, we performed isointegral distribution mapping using a 64-electrode balloon array inserted in the right atrium under cardiopulmonary bypass in 9 anesthetized mongrel dogs. Unipolar electrograms were recorded during stimulation of either the right or left vagus nerve or right atrialpulmonary vein ganglionated plexus before and after surgical ablation of tissues along the superior vena cava, of the right atrial-pulmonary vein ganglionated plexus, the aorto-pulmonary tissues and the inferior vena cava fat pad. Local neural effects were estimated from integral changes of each electrogram which were plotted on a septal grid to generate isointegral distribution maps. Changes were considered significant whenever integral differences exceeded twice the standard deviation of control values. Stimulation of the right and left vagi induced significant effects in the high atrial septum in 5 preparations and in the low septum in 6. These effects were suppressed by the dissection of tissues around the superior vena cava and ablation of the right atrial-pulmonary vein ganglionated plexus, but not by that of the inferior vena cava or the aorto-pulmonary tissues. Direct stimulation of the right atrial-pulmonary vein ganglionated plexus produced effects in the high and low septum in 8 and 4 preparations, respectively, which persisted after dissection around the superior vena cava, suggesting the existence of local circuit neural elements. We conclude that the canine atrial septum is innervated by axons from both vagi which course near the superior vena cava and converge through the right atrial-pulmonary vein ganglionated plexus and also by intrinsic neural elements independent of central parasympathetic efferents.
Do
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QB
Service de Chirurgie Cardiaque, Hôpital du Sacré-Coeur de Montreal, Québec, Canada.
Dandan
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N
Cardinal
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R
Pagé
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P
D000818:Animals; D001341:Autonomic Nervous System / Q000033:anatomy & histology; D003714:Denervation; D004195:Disease Models, Animal; D004285:Dogs; D004562:Electrocardiography / Q000379:methods*; D006325:Heart Atria / Q000294:innervation* / Q000503:physiopathology; D006339:Heart Rate; D006346:Heart Septum / Q000294:innervation* / Q000503:physiopathology; D010275:Parasympathetic Nervous System / Q000033:anatomy & histology