title: Olfactory bulbectomy increases prepro-galanin mRNA levels in the rat locus coeruleus.
abstract: The effects of olfactory bulbectomy (OBX) on galanin (GAL) gene expression in the locus coeruleus (LC) were examined with quantitative in situ hybridization histochemistry. OBX increased prepro-GAL levels 3 and 14 days after surgery, as compared to sham-operated controls. Levels of mRNA encoding prepro-neuropeptide Y (NPY) were unchanged, and levels of mRNA encoding tyrosine hydroxylase (TH) were elevated in the LC only on day 3. The results indicate that GAL gene expression in the LC increases after lesioning a terminal field.
authors.affiliation: Section on Behavioral Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20892-1380, USA.
authors.forename: P V
authors.initials: PV
authors.lastname: Holmes
authors.forename: J N
authors.initials: JN
authors.lastname: Crawley
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D019004:Galanin / Q000235:genetics*; D015870:Gene Expression; D005815:Genetic Code; D008125:Locus Coeruleus / Q000166:cytology / Q000378:metabolism*; D008297:Male; D009434:Neural Pathways; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D009478:Neuropeptide Y / Q000235:genetics; D009830:Olfactory Bulb / Q000502:physiology*; D011498:Protein Precursors / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics
chemical_list: D009478:Neuropeptide Y; D011498:Protein Precursors; D012333:RNA, Messenger; D019004:Galanin; C042084:preproneuropeptide Y; D014446:Tyrosine 3-Monooxygenase