title: Ovarian pregnancies treated with methotrexate.
abstract: Medical therapy in ectopic and ovarian pregnancies in particular, can be a valid alternative to the surgical approach, since it can guarantee the reproductive function in a better way. More and more attempts with methotrexate, which can induce the death of both embryo and trophoblastic tissue, are being made. Both its administration and results are still under debate. In our case histories, three clinical cases are reported and two of them proved to be successful. In our opinion, apart from the method of administration, the prerequisites for a therapeutic success are: a small ovular sac (max 30 mm), no echographically visible embryo which corresponds to a six-week pregnancy. The success of the therapy, therefore, depends on the precociousness of the diagnosis.
authors.affiliation: Santa Maria delle Grazie Hospital, USL 22-Pozzuoli, Naples, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Annunziata
authors.forename: E
authors.initials: E
authors.lastname: Malignino
authors.forename: R
authors.initials: R
authors.lastname: Zarcone
mesh_terms: D000328:Adult; D005260:Female; D005493:Folic Acid Antagonists / Q000627:therapeutic use*; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use*; D010053:Ovary; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000188:drug therapy*
chemical_list: D005493:Folic Acid Antagonists; D008727:Methotrexate