Radiological signs in newborns exposed to primary Toxoplasma infection in utero.
A total of 44 181 serum samples from 16 733 pregnant women were analyzed for findings suggesting primary Toxoplasma infection. Thirty-seven newborns exposed to maternal primary Toxoplasma infection in utero were studied prospectively with ultrasound, CT, and MRI for signs of intrauterine infection. Their mothers had been treated during pregnancy, and all infants were treated. The children were assigned to three groups according to their mothers' serological status, and the radiological results were compared with the clinical outcome. Although radiological signs were scarce, ultrasound findings combined with maternal serology were found to be significantly related to clinical outcome.
Virkola
K
K
Department of Radiology, Children's Hospital, University of Helsinki, Stenbäckink 11, FIN-00290 Helsinki, Finland.
Lappalainen
M
M
Valanne
L
L
Koskiniemi
M
M
D000005:Abdomen / Q000469:parasitology; D000913:Antibodies, Protozoan / Q000097:blood; D003952:Diagnostic Imaging; D005260:Female; D005865:Gestational Age; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000097:blood / Q000188:drug therapy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012737:Sex Factors; D014057:Tomography, X-Ray Computed; D014123:Toxoplasmosis / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000635:transmission; D016781:Toxoplasmosis, Cerebral / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy; D014125:Toxoplasmosis, Congenital / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy; D016896:Treatment Outcome; D014463:Ultrasonography
D000913:Antibodies, Protozoan; D007074:Immunoglobulin G; D007075:Immunoglobulin M