Actions of lidocaine on reentrant ventricular rhythms in the subacute myocardial infarction period in dogs.
The actions of lidocaine were studied in 18 dogs, 4 days after ligation of the left anterior descending artery, by computerized mapping. Lidocaine only occasionally suppressed the induction of reentry. At fast heart rates, lidocaine actually facilitated the induction of reentry. The effects on conduction and refractoriness of normal and ischemic myocardium were measured using high-resolution techniques. Lidocaine promoted reentry by a rate-dependent increase in refractory gradient, resulting in additional block, and a selective decrease in conduction velocity in ischemic tissue, resulting in additional conduction delay. Lidocaine could prevent reentry through a rate-independent differential increase in refractory period gradient at the entrance to the common pathway of the circuit, causing block of the reentrant impulse. We conclude that the proarrhythmic effect of lidocaine is due to increased conduction delay and block while the antiarrhythmic effect is due to block of the reentrant impulse by prolonged refractoriness in the common pathway.
Yin
H
H
State University of New York Health Sciences Center at Brooklyn, USA.
el-Sherif
N
N
Caref
E B
EB
Ndrepepa
G
G
Levin
R
R
Isber
N
N
Stergiopolus
K
K
Assadi
M A
MA
Gough
W B
WB
Restivo
M
M
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000209:etiology; D004285:Dogs; D006329:Heart Conduction System / Q000187:drug effects / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D008012:Lidocaine / Q000494:pharmacology*; D009203:Myocardial Infarction / Q000503:physiopathology*; D017202:Myocardial Ischemia / Q000503:physiopathology; D010507:Periodicity; D012016:Reference Values; D012032:Refractory Period, Electrophysiological / Q000187:drug effects; D013997:Time Factors; D016276:Ventricular Function / Q000187:drug effects*
D000889:Anti-Arrhythmia Agents; D008012:Lidocaine