Sustained-release methylphenidate for cognitive impairment in HIV-1-infected drug abusers: a pilot study.
Other investigators have reported clinical improvement from psychostimulant drugs in patients with HIV-1-related cognitive impairment. However, no previous research has substantiated this claim by using a controlled study design. We examined the efficacy of sustained-release methylphenidate (MSR) in a sample of substance abusers with HIV-1-related cognitive impairment. Eight HIV-1-infected methadone patients with impaired neuropsychological test performance participated in an inpatient double-blind placebo-controlled crossover trial of MSR 20-40 mg/day. On a composite neuropsychological measure, patients improved significantly from baseline during MSR but not placebo treatment. Nevertheless, MSR performance did not differ significantly from placebo performance. Patients appeared to improve as a function of time, regardless of sequence, with somewhat more improvement during MSR than placebo treatment.
van Dyck
C H
CH
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.
McMahon
T J
TJ
Rosen
M I
MI
O'Malley
S S
SS
O'Connor
P G
PG
Lin
C H
CH
Pearsall
H R
HR
Woods
S W
SW
Kosten
T R
TR
D000328:Adult; D001288:Attention / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000627:therapeutic use*; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000523:psychology*; D015497:HIV-1; D006801:Humans; D007858:Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D008774:Methylphenidate / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D009483:Neuropsychological Tests; D009293:Opioid-Related Disorders / Q000523:psychology; D010865:Pilot Projects; D011597:Psychomotor Performance / Q000187:drug effects; D019966:Substance-Related Disorders / Q000150:complications / Q000523:psychology*
D000697:Central Nervous System Stimulants; D003692:Delayed-Action Preparations; D008774:Methylphenidate