title: A comparative trial of standard or high-dose S subunit recombinant hepatitis B vaccine versus a vaccine containing S subunit, pre-S1, and pre-S2 particles for revaccination of healthy adult nonresponders.
abstract: The efficacy of 10-microg and 40-microg hepatitis B vaccines was compared with that of an investigational vaccine containing pre-S1, pre-S2, and S subunit particles (mixed particle vaccine) in inducing protective anti-hepatitis B surface antigen (anti-HBs) concentrations in 46 otherwise healthy persons who previously did not develop measurable levels of antibodies to at least one complete course of vaccine. A statistically significant difference was seen in the percentage of subjects who developed protective levels of anti-HBs (> or = 10 mIU/mL) with three 40-microg doses of S subunit vaccine versus the other groups. One hundred percent of the 40-microg dose group developed protective anti-HBs titers. No difference in adverse effects was noted.
authors.affiliation: Bassett Healthcare, Cooperstown, New York 13326-1394, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Bertino
authors.forename: P
authors.initials: P
authors.lastname: Tirrell
authors.forename: R N
authors.initials: RN
authors.lastname: Greenberg
authors.forename: H L
authors.initials: HL
authors.lastname: Keyserling
authors.forename: G A
authors.initials: GA
authors.lastname: Poland
authors.forename: D
authors.initials: D
authors.lastname: Gump
authors.forename: M L
authors.initials: ML
authors.lastname: Kumar
authors.forename: K
authors.initials: K
authors.lastname: Ramsey
mesh_terms: D000328:Adult; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006510:Hepatitis B Antibodies / Q000096:biosynthesis*; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014614:Vaccines, Synthetic / Q000008:administration & dosage
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic