Leptin and OB-R: body weight regulation by a cytokine receptor.
There has been intense recent interest in the molecules and pathways governing mammalian body weight regulation. Leptin (OB), an ancestral member of the cytokine family, is an adipocyte-secreted circulating hormone exhibiting weight regulatory properties. Recently, the leptin receptor (OB-R) was identified and shown to exhibit sequence homology and functional similarity to members of the class I cytokine receptor family. The mechanisms governing OB-R triggering and signal transduction have begun to be elucidated, providing new insight into the pathways controlling mammalian body weight homeostasis.
White
D W
DW
Millennium Pharmaceuticals, Cambridge, MA 02139, USA.
Tartaglia
L A
LA
D000273:Adipose Tissue / Q000502:physiology; D000818:Animals; D001835:Body Weight; D002352:Carrier Proteins / Q000502:physiology*; D003001:Cloning, Molecular; D007031:Hypothalamus / Q000502:physiology; D020738:Leptin; D051379:Mice; D008817:Mice, Mutant Strains; D008820:Mice, Obese / Q000502:physiology; D010227:Parabiosis; D011506:Proteins / Q000502:physiology*; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; D015398:Signal Transduction
D002352:Carrier Proteins; D020738:Leptin; D011506:Proteins; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; C515447:leptin receptor, mouse