title: Low diagnostic value of respiratory impedance measurements in children.
abstract: The aim of this study was to determine whether impedance values in children with various chronic respiratory complaints differed from those observed in symptom-free children. Respiratory impedance was measured using the forced oscillation technique in 1,776 Dutch children aged 6-12 yrs. In addition to the commonly used parameters of resistance and reactance, further impedance parameters were obtained by using linear and quadratic regression to describe individual resistance and reactance curves as a function of frequency. Furthermore, the diagnostic value of the individual impedance parameters was evaluated by means of receiver operator characteristic (ROC) curves. Statistically significant differences in impedance values were found in girls with symptoms suggesting asthma compared to symptom-free girls, but not in boys. In children with chronic cough, impedance was not significantly different from the values of symptom-free children. The results obtained by the additional impedance parameters were comparable to those of the commonly used measures. We conclude that the diagnostic values of the impedance parameters appeared to be low, as no cut-off points were found to discriminate clearly between symptomatic and symptom-free children. These findings may reflect absence of functional abnormalities in symptomatic children at this age.
authors.affiliation: Dept of Epidemiology, University of Maastricht, The Netherlands.
authors.forename: C E
authors.initials: CE
authors.lastname: Cuijpers
authors.forename: G J
authors.initials: GJ
authors.lastname: Wesseling
authors.forename: A G
authors.initials: AG
authors.lastname: Kessels
authors.forename: G M
authors.initials: GM
authors.lastname: Swaen
authors.forename: P L
authors.initials: PL
authors.lastname: Mertens
authors.forename: M E
authors.initials: ME
authors.lastname: de Kok
authors.forename: J
authors.initials: J
authors.lastname: Broer
authors.forename: F
authors.initials: F
authors.lastname: Sturmans
authors.forename: E F
authors.initials: EF
authors.lastname: Wouters
mesh_terms: D000403:Airway Resistance / Q000502:physiology; D001249:Asthma / Q000175:diagnosis / Q000503:physiopathology; D002648:Child; D002908:Chronic Disease; D015331:Cohort Studies; D003371:Cough / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D009991:Oscillometry; D012372:ROC Curve; D012044:Regression Analysis; D015656:Respiratory Mechanics / Q000502:physiology*; D012135:Respiratory Sounds / Q000175:diagnosis / Q000503:physiopathology; D012140:Respiratory Tract Diseases / Q000175:diagnosis* / Q000503:physiopathology; D012680:Sensitivity and Specificity; D012737:Sex Factors