Interleukin-12 suppresses immunoglobulin E production but enhances immunoglobulin G4 production by human peripheral blood mononuclear cells.
The effect of interleukin-12 (IL-12) on human immunoglobulin G4 (IgG4) and IgE production was examined with cells derived from filarial patients and European controls. IL-12 inhibited IgE release but enhanced IgG4 production in cultures of peripheral blood mononuclear cells stimulated with anti-CD2 plus IL-2. When purified T- and B-cell cocultures were examined, IL-12 again markedly enhanced IgG4, whereas IgE production was no longer inhibited.
de Boer
B A
BA
Department of Parasitology, Faculty of Medicine, Leiden University, The Netherlands.
Kruize
Y C
YC
Rotmans
P J
PJ
Yazdanbakhsh
M
M
D000818:Animals; D002478:Cells, Cultured; D005368:Filariasis / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007371:Interferon-gamma / Q000502:physiology; D018664:Interleukin-12 / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D051379:Mice; D011817:Rabbits
D007074:Immunoglobulin G; D018664:Interleukin-12; D007073:Immunoglobulin E; D007371:Interferon-gamma