The lethal (2) giant larva (l(2)gl), a recessive oncogene, is required during embryonic and post-embryonic development in Drosophila.
Recessive oncogenes have genetic functions important for the regulation of tissue growth and differentiation. Defining the role of these genes in normal developmental and physiological processes is important to the development of the accurate models of the normal regulation of growth and differentiation. We report here a genetic analysis of the requirement for the lethal (2) giant larva function during development. The results demonstrate that the lethal (2) giant larva function is required during embryonic and post-embryonic development to maintain the normal developmental capacity.
Baek
K H
KH
Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA. baek@rascal.med.harvard.edu
Hanratty
W P
WP
D000818:Animals; D004330:Drosophila / Q000196:embryology / Q000235:genetics* / Q000254:growth & development; D005260:Female; D017344:Genes, Insect / Q000502:physiology*; D005808:Genes, Recessive / Q000502:physiology*; D005809:Genes, Regulator / Q000502:physiology; D009857:Oncogenes / Q000502:physiology*; D010641:Phenotype