title: [First intention treatment of arterial hypertension using a combination of two drugs].
abstract: The limited efficacy of single-drug regimens in the treatment of high blood pressure has led to an evaluation of combination regimens for first intention treatment. Two-drug regimens favor the hypotensive efficacy and reduce the frequency of certain side effects. Medications combining two drugs in a single formulation would allow use as first line treatment although marketing authorizations have not yet been obtained. In addition, current good clinical practice recommendations do not allow combination therapy in this situation. A complete assessment based on medical results and cost effectiveness will undoubtedly confirm the usefulness of two-drug therapies as first line treatment for moderate hypertension.
authors.affiliation: Service de Médecine interne et thérapeutique, Hôpital Broussais, Paris.
authors.forename: X
authors.initials: X
authors.lastname: Girerd
authors.forename: J
authors.initials: J
authors.lastname: Blacher
authors.forename: J J
authors.initials: JJ
authors.lastname: Mourad
authors.forename: M
authors.initials: M
authors.lastname: Safar
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage*; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations