[The biological range and characteristics of the importance of adenosine receptors for the resistance of the brain to total ischemia].
In the total brain ischemia the cerebroprotective effect (CPE) of adenosine was pronounced in the following order: mouse > rat approximately guinea pig (males > females). The sensitizing effect (SE) of theophylline is the same in different species but is more pronounced in females compared to males. Newborn rats are much more tolerant to the total brain ischemia. The adenosine CPE increases and the theophylline SE decreases with age. The adenosine receptor component, evidently, contributes greatly to the natural tolerance of newborn animals to the total brain ischemia.
Kulinskiĭ
V I
VI
Sufianova
G Z
GZ
Usov
L A
LA
D000241:Adenosine / Q000494:pharmacology; D000375:Aging / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D002545:Brain Ischemia / Q000503:physiopathology*; D005260:Female; D006168:Guinea Pigs; D007113:Immunity, Innate / Q000187:drug effects; D008297:Male; D051379:Mice; D051381:Rats; D018047:Receptors, Purinergic P1 / Q000187:drug effects* / Q000502:physiology; D012727:Sex Characteristics; D013045:Species Specificity; D013806:Theophylline / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology
D018047:Receptors, Purinergic P1; D014665:Vasodilator Agents; D013806:Theophylline; D000241:Adenosine