title: [Efficacy and tolerability of a combination of indomethacin and gentamicin for preventing inflammation after cataract surgery].
abstract: OBJECTIVE
  The aim of the study was to compare 2 combinations of anti-inflammatory drug and antibiotic, in patients undergoing cataract surgery: 0.1% indomethacin/gentamicin or 0.1% dexamethasone/ neomycin.
  
  
  METHODS
  Two hundred and two patients undergoing extra-capsular cataract extraction with posterior chamber lens implantation were included in a randomized, double-blinded multicentric study comparing 2 parallel groups of treatment. Treatment was administered the day before surgery, the day of surgery and for the following 7 days. On the 8th post-operative day, the antibiotic was stopped and the anti-inflammatory treatment continued alone until the 30th post-operative day. Post-operative ocular inflammation was assessed clinically on the 1st, 7th, 15th and 30th post-operative days. The main evaluation criterion of treatment efficacy was the assessment of anterior chamber flare and cells.
  
  
  RESULTS
  No statistically significant difference-was observed between the 2 treatment groups concerning post-operative inflammation. Both treatments were well tolerated.
  
  
  CONCLUSIONS
  Eye drops combining 0.1% indomethacin and gentamicin proved to be effective and well tolerated in preventing inflammation after cataract surgery.
authors.affiliation: Hôtel-Dieu, Paris.
authors.forename: G
authors.initials: G
authors.lastname: Renard
authors.forename: J P
authors.initials: JP
authors.lastname: Adenis
authors.forename: J F
authors.initials: JF
authors.lastname: Rouland
authors.forename: J C
authors.initials: JC
authors.lastname: Dascotte
authors.forename: G
authors.initials: G
authors.lastname: Brasseur
authors.forename: J L
authors.initials: JL
authors.lastname: Couderc
authors.forename: T
authors.initials: T
authors.lastname: Hoang-Xuan
authors.forename: M
authors.initials: M
authors.lastname: Ullern
authors.forename: C
authors.initials: C
authors.lastname: Allaire
authors.forename: C
authors.initials: C
authors.lastname: Trinquand
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D002387:Cataract Extraction; D003907:Dexamethasone / Q000627:therapeutic use; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005839:Gentamicins / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects / Q000627:therapeutic use*; D007249:Inflammation / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005839:Gentamicins; D003907:Dexamethasone; D007213:Indomethacin