title: Chemoprevention of carcinogen-DNA binding: the relative role of different oxygenated substituents on 4-methylcoumarins in the inhibition of aflatoxin B1-DNA binding in vitro.
abstract: Eighteen 4-methylcoumarins bearing methoxy/hydroxy/acetoxy functionalities have been reported to effectively inhibit the rat liver microsome-mediated aflatoxin B1-DNA binding in vitro. The contribution of functionality on coumarin nucleus towards the inhibition of AFB1-DNA binding is in the order acetoxy > hydroxy > methoxy. The results illustrate the structure-activity relationship.
authors.affiliation: Department of Biochemistry, V.P. Chest Institute, University of Delhi, India.
authors.forename: H G
authors.initials: HG
authors.lastname: Raj
authors.forename: S
authors.initials: S
authors.lastname: Gupta
authors.forename: G
authors.initials: G
authors.lastname: Biswas
authors.forename: S
authors.initials: S
authors.lastname: Singh
authors.forename: A
authors.initials: A
authors.lastname: Singh
authors.forename: A
authors.initials: A
authors.lastname: Jha
authors.forename: K S
authors.initials: KS
authors.lastname: Bisht
authors.forename: S K
authors.initials: SK
authors.lastname: Sharma
authors.forename: S C
authors.initials: SC
authors.lastname: Jain
authors.forename: V S
authors.initials: VS
authors.lastname: Parmar
mesh_terms: D016604:Aflatoxin B1 / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D002273:Carcinogens / Q000378:metabolism* / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D004247:DNA / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
chemical_list: D002273:Carcinogens; D003374:Coumarins; D004247:DNA; D016604:Aflatoxin B1; C030123:coumarin