Chemoprevention of carcinogen-DNA binding: the relative role of different oxygenated substituents on 4-methylcoumarins in the inhibition of aflatoxin B1-DNA binding in vitro.
Eighteen 4-methylcoumarins bearing methoxy/hydroxy/acetoxy functionalities have been reported to effectively inhibit the rat liver microsome-mediated aflatoxin B1-DNA binding in vitro. The contribution of functionality on coumarin nucleus towards the inhibition of AFB1-DNA binding is in the order acetoxy > hydroxy > methoxy. The results illustrate the structure-activity relationship.
Raj
H G
HG
Department of Biochemistry, V.P. Chest Institute, University of Delhi, India.
Gupta
S
S
Biswas
G
G
Singh
S
S
Singh
A
A
Jha
A
A
Bisht
K S
KS
Sharma
S K
SK
Jain
S C
SC
Parmar
V S
VS
D016604:Aflatoxin B1 / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D002273:Carcinogens / Q000378:metabolism* / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D004247:DNA / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
D002273:Carcinogens; D003374:Coumarins; D004247:DNA; D016604:Aflatoxin B1; C030123:coumarin