Dibenz[b,f]azepines, Part 7. Synthesis of new, potentially CNS active dibenz[b,f]azepine derivatives.
Reactions of 5-carboxamido-5H-dibenz[b,f]azepines (1a-1d) with glyoxylic acid methylester methyl hemiacetal (GMHA) led to 5-(carboxamido-N-alpha-hydroxy-acetic acid methyl ester)-5H- dibenz[b,f]azepines (2a-2d). The reactions with glycols yielded the oligoethylene glycol derivatives (3,4). The new compounds were screened as anticonvulsants and/or antidepressants (AD).
Haász
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Alkaloida Chemical Company Ltd., Tiszavasvári, Hungary.
Tóth
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Galamb
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D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002492:Central Nervous System Depressants / Q000037:antagonists & inhibitors; D003984:Dibenzazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D004597:Electroshock; D005260:Female; D008297:Male; D051379:Mice; D012110:Reserpine / Q000037:antagonists & inhibitors
D000927:Anticonvulsants; D000928:Antidepressive Agents; D002492:Central Nervous System Depressants; D003984:Dibenzazepines; D012110:Reserpine