Accidental intoxication with methylene dianiline p,p'-diaminodiphenylmethane: acute liver damage after presumed ecstasy consumption.
BACKGROUND
MDA is the abbreviation for methylene dianiline (p,p' diaminodiphenylmethane; 4,4'-methylenedianiline; CAS 101-77-9); and for methylendioxyamphetamine (MDMA, N, alpha-dimethyl-1,3-benzodioxole-5-ethanamine; CAS 42542-10-9). While the former is used for the production of polyurethane foams, the latter is a psychometric drug, which is becoming increasingly popular in the techno scene.


METHODS
We report six participants of a technoparty (1 female, 5 males, ages 17-25) who were admitted to the hospital with severe colicky abdominal pain and subsequently developed symptoms of hepatotoxicity. They had ingested an alcoholic beverage that had been spiked with a powdery substance they dubbed MDA.


RESULTS
All patients showed similar clinical symptoms, with an identical time course. Acute jaundice developed within 2 days after ingestion. Enzymes indicating cholestasis increased steadily over 7 days and reached peak values of 800 U/L (AP) and 380 U/L (GGT), whereas transaminases remained moderately elevated. Between days 5 and 7, all patients became febrile for one day, their body temperatures rising up to 40 degrees C. There was no evidence for hemolysis or an infectious hepatitis. Toxicological analysis revealed the presence of p,p'-diaminodiphenylmethane (4,4'-methylenedianiline) at a concentration of 130 mg/L in one of two urine extracts examined.


CONCLUSIONS
The analytical data indicate that the participants of the technoparty assumed the aniline-derivative, the cause of Epping Jaundice, was methylendioxyamphetamine because the same abbreviation, MDA, is used for both compounds. An overview of the acute liver toxicity of aniline derivatives is given and the possibility of amphetamine-induced liver damage is discussed.
Tillmann
H L
HL
Medizinische Hochschule Hannover, Germany.
van Pelt
F N
FN
Martz
W
W
Luecke
T
T
Welp
H
H
Dörries
F
F
Veuskens
A
A
Fischer
M
M
Manns
M P
MP
D015104:3,4-Methylenedioxyamphetamine / Q000506:poisoning; D000293:Adolescent; D000328:Adult; D000814:Aniline Compounds / Q000097:blood / Q000633:toxicity* / Q000652:urine; D002273:Carcinogens / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000209:etiology*; D008111:Liver Function Tests; D008297:Male; D008499:Medical Records; D001559:Benzhydryl Compounds
D015104:3,4-Methylenedioxyamphetamine; D000814:Aniline Compounds; D002273:Carcinogens; C009505:4,4'-diaminodiphenylmethane; D001559:Benzhydryl Compounds