title: Serotonin 5-HT3 receptor binding kinetics in the cortex of suicide victims are normal.
abstract: Serotonergic abnormalities have been identified in the brain of suicide victims independent of psychiatric diagnosis. We report the first study of serotonin 5-HT3 receptors in the brain of suicide victims. There were no differences in the number (Bmax) or affinity (KD) of 5-HT3 receptors in the temporal cortex of suicide victims compared to matched controls. There was a negative correlation between brain serotonin levels and receptor number (r = -0.5, p = 0.04) in both groups. This study indicates that alterations in serotonergic function in the brain of suicide victims do not appear to directly involve the 5-HT3 receptor.
authors.affiliation: Department of NEuroscience, New York State Psychiatric Institute, New York, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Mann
authors.forename: V
authors.initials: V
authors.lastname: Arango
authors.forename: R A
authors.initials: RA
authors.lastname: Henteleff
authors.forename: T F
authors.initials: TF
authors.lastname: Lagattuta
authors.forename: D T
authors.initials: DT
authors.lastname: Wong
mesh_terms: D000328:Adult; D001923:Brain Chemistry / Q000502:physiology; D002540:Cerebral Cortex / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007191:Indazoles; D007700:Kinetics; D008297:Male; D011985:Receptors, Serotonin / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists; D013405:Suicide; D014326:Tropanes; D014364:Tryptophan / Q000378:metabolism
chemical_list: D007191:Indazoles; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D014326:Tropanes; C061531:LY 278584; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan