[Connection between the level of transferrin in blood plasma and the level of malondialdehyde in mouse liver].
To study possible correlation between plasma transferrin content and level of 2-thiobarbituric acid-reactive substances (malonic dialdehyde (MDA)) in the liver of mice, these parameters were assayed during brombenzol-induced lipid peroxidation and when this process was inhibited by zinc-metallothionein (zinc-MT). In 24 h after brombenzol injection (0.5-2 g/kg intraperitoneally), mice had decreased blood transferrin concentration and increased MDA level in the liver. On the contrary, in 24 h after the zinc-MT injection (1-4 mg/kg intraperitoneally), blood transferrin concentration was 2-3-fold increased and liver MDA content was 2-3-fold decreased. The effects of zinc-MT were observed even in brombenzol-injected animals. Zinc-MT injection increased total transferrin content in the blood and decreased glycosylation of this glycoprotein. Changes in blood transferrin content negatively correlates (r = -0.75) with changes in liver MDA. The data confirm that plasma transferrin can participate in regulation of tissue lipid peroxidation.
Kon'
I Ia
IIa
Shilina
N M
NM
Koterov
A N
AN
D000818:Animals; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D008668:Metallothionein / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D014168:Transferrin / Q000378:metabolism*
D014168:Transferrin; C021267:zinc thionein; D008315:Malondialdehyde; D008668:Metallothionein