[Lung transplantation in cystic fibrosis].
OBJECTIVE
Since 1990 we have performed 40 lung transplants in the Hospital "La Fe" in Valencia. Nine of them have been performed in cystic fibrosis patients, which is the subject of this paper.


METHODS
The mean age of the patients was 19.8 years, with the youngest patient being 14 years of age. In regards to patient selection, it is important to mention that one had a previous lobectomy, another one a thoracic deformity due to long term atelectasis and one needed intubation for hemoptysis within the 7 days before the lung transplant. Prophylaxis with imipenem and cyprofloxicin, aerosolized colistin and amphotericin B, prompt weaning and intensive respiratory physiotherapy were important for controlling postoperative infection.


RESULTS
With 15.3 months as the mean follow-up (range 36-3), 3 year survival was 87.5%. Pulmonary infection, which was the most frequent complication, had a good response to adequate antibiotic treatment. The main postoperative problem pertained to the bronchial suture with 2 partial dehiscences, 2 stenoses and one bronchopleural fistula by Aspergillus, all of which were resolved with conservative procedures without surgery.


CONCLUSIONS
Middle and long term evolution in these patients shows an excellent quality of life with spirometric and ergometric tests within the normal range.
Borro Maté
J M
JM
Servicio de Cirugía Torácica, Hospital Universitario La Fe, Valencia.
Calvo Medina
V
V
Morant Guillén
P
P
Morales Marín
P
P
Vicente Guillén
R
R
Tarrazona Hervas
V
V
Ramos Briones
F
F
Lozano Ruiz
C
C
Ferrer Calvete
F
F
D000293:Adolescent; D000328:Adult; D003550:Cystic Fibrosis / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D015774:Ganciclovir / Q000627:therapeutic use; D006084:Graft Rejection / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D017053:Infection Control; D008168:Lung / Q000503:physiopathology / Q000601:surgery*; D016040:Lung Transplantation; D008297:Male; D011788:Quality of Life
D007166:Immunosuppressive Agents; D015774:Ganciclovir