[Piperazine analogs of aryloxyaminopropanols and a study of their effects on a model of the isolated guinea pig ileum].
Seven compounds belonging to the group of aryloxyaminopropanols with carbamate substitution of the aromatic ring and with derivatives of N-phenylpiperazine in the lipophilic part were prepared by a well-tried method. Selected drugs were pharmacologically evaluated by in vitro experiments. Aryloxyaminopropanol drugs confirmed their anti-calcium activity on the intestinal model. Significant anti-calcium activity of agents IIIq and IIIb (pA2 = 6,83 +/- 1,47; 7, 12 +/- 1, 12 was comparable to that found for the standards verapamil and flunarizine. These compounds were selected for in vivo experiments and evaluated for their effect on reperfusion-induced arrhythmias in anaesthetized rats. Results of these evaluations are given in the next article.
Celková
H
H
Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava.
Csöllei
J
J
Cizmárik
J
J
Jadronová
O
O
Seginko
J
J
D000818:Animals; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D010879:Piperazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D010879:Piperazines