Antinociceptive effects of intrathecally administered 2-methylserotonin in developing rats.
The present study examined developmental patterns of antinociception mediated by the spinal 5-HT3 receptor system in the neonatal rat. Intrathecally administered 2-methylserotonin (25-100 micrograms) first produced antinociception against formalin-induced acute inflammatory pain at 10 days postnatally, with effect only at the peak dose (100 micrograms). Intrathecal 2-methylserotonin produced dose-dependent antinociception at 14 and 28 days of age that was attenuated by i.t. pretreatment with the 5-HT3 receptor antagonist MDL-72222 (10 micrograms).
Giordano
J
J
Department of Nursing, Neuroscience Section, Lamar University, Beaumont, TX 77710, USA.
D000818:Animals; D000831:Animals, Newborn; D004305:Dose-Response Relationship, Drug; D005557:Formaldehyde; D007249:Inflammation / Q000139:chemically induced; D007278:Injections, Spinal; D008297:Male; D009619:Nociceptors / Q000187:drug effects*; D010147:Pain Measurement; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000031:analogs & derivatives* / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology; D013116:Spinal Cord / Q000737:chemistry / Q000187:drug effects / Q000254:growth & development*; D014326:Tropanes / Q000494:pharmacology
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D014326:Tropanes; D005557:Formaldehyde; D012701:Serotonin; C045918:2-methyl-5-HT; C042253:bemesetron