Pentoxifylline inhibits tumor necrosis factor alpha-induced priming of human neutrophils.
The study was designed to study the effect of pentoxifylline PTX on the chemiluminescence responses of neutrophils and on tumor necrosis factor-alpha (TNF-alpha)-induced priming of neutrophils. The results demonstrate that TNF-alpha stimulated the respiratory burst by neutrophils and primed them for enhanced response to fMLP but not to PMA. The effect of TNF-alpha on the oxygen metabolism of neutrophils was inhibited when cells were treated with PTX. This reaction was dose-dependent. Additionally, the inhibiting influence of PTX on the chemiluminescence response of neutrophils was observed.
Paradowski
P T
PT
Department of Orthopedics and Traumatology, Military School of Medicine, Lódź, Poland.
Zeman
K
K
Pietruszyński
R
R
D004305:Dose-Response Relationship, Drug; D006801:Humans; D007700:Kinetics; D008163:Luminescent Measurements; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D010431:Pentoxifylline / Q000494:pharmacology*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology; D016897:Respiratory Burst / Q000187:drug effects; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D010726:Phosphodiesterase Inhibitors; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D009240:N-Formylmethionine Leucyl-Phenylalanine; D013755:Tetradecanoylphorbol Acetate; D010100:Oxygen; D010431:Pentoxifylline