[The plasma level of kanamycin after intravenous and intramuscular injections in horses].
A therapeutical dose of kanamycin was tested intravenously and intramuscularly in four normal standardbreds and plasma concentrations were measured over a 12 hour period. Plasma levels exceeded a minimum inhibitory concentration of 4 micrograms/ml within only 15 minutes for 8 hours both after i.v. and i.m. injection. Kanamycin revealed a mean plasma half life of 2.3 hours. Bioavailability of an intramuscular dose was about 76%. The pharmacokinetic parameters demonstrate the rapid onset of antibacterial plasma levels of the test compound. A dose regimen for horses of two times daily 5 mg/kg body weight ensures therapeutically effective plasma levels. The risk of accumulation as well as nephro- or ototoxic side effects are negligible at short-term treatment.
Klee
S
S
Institut für Pharmakologie und Toxikologie, FU Berlin.
Nürnberger
M C
MC
Keller
H
H
Ungemach
F R
FR
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D005260:Female; D006207:Half-Life; D006736:Horses / Q000097:blood*; D007273:Injections, Intramuscular / Q000662:veterinary; D007275:Injections, Intravenous / Q000662:veterinary; D007612:Kanamycin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male
D000900:Anti-Bacterial Agents; D007612:Kanamycin