title: [Changes of the cutaneous micro-relief in superficial radiation-induced fibrosis: a qualitative study].
abstract: Cutaneous radiation-induced fibrosis (RIF) is characterized by a skin retraction or atrophy, toughness to the palpation and often entails functional limitation. Its clinical evaluation remains poorly quantified. The aim of this study was to propose an analytical method to quantify RIF skin surface with the replica technique. In this preliminary study, we report the qualitative and quantitative evaluation of the cutaneous microrelief in 44 healthy controls and in four patients presenting a superficial RIF, 3 to 20 years after radiotherapy for cancer. The microrelief of these RIF presented an abnormal anisotropy with a parallel reorganization of cutaneous valleys in three cases out of four, suggesting a premature radiation-induced ageing of the skin. Each subject being his own control, the relative vertical amplitude of the skin microrelief was +/-15% in control skin. Vertical amplitude was respectively increased by 84% in one inflammatory fibrosis (3 years after RT), decreased by 18% in one evolutive fibrosis (6 years after RT), decreased by 26% in one voluminous stabilized fibrosis (8 years after RT) and decreased by 53% in one atrophic fibrosis (20 years after RT). The present study suggests that the variations of the microrelief parameters could reflect the RIF evolution. This technique requires a validation in a larger series of patients, including patients with telangiectasia.
authors.affiliation: Laboratoire de radiobiologie et d'étude du génome, DSV-DRR-CEA-Saclay, Gif-sur-Yvette, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Lefaix
authors.forename: S
authors.initials: S
authors.lastname: Delanian
authors.forename: B
authors.initials: B
authors.lastname: Dubray
authors.forename: P
authors.initials: P
authors.lastname: Giraud
authors.forename: E
authors.initials: E
authors.lastname: Berland
authors.forename: S
authors.initials: S
authors.lastname: Sahraoui
authors.forename: J
authors.initials: J
authors.lastname: Mignot
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005355:Fibrosis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011855:Radiodermatitis / Q000473:pathology*; D011878:Radiotherapy / Q000009:adverse effects*; D012867:Skin / Q000473:pathology* / Q000528:radiation effects; D015595:Skin Aging