title: Human lymphocyte micronucleus genotoxicity test with mixtures of phytochemicals in environmental concentrations.
abstract: This study was carried out to assess the genotoxicity of mixtures of pesticides using the micronucleus test with human lymphocytes in culture. Benomyl, azinphos-methyl, diazinon, dimethoate, pirimiphos-methyl pesticides were tested at doses estimated from their daily intake (EDI). Benomyl is a carbamate fungicide, the other compounds are organophosphorous insecticides. The compounds were tested both separately and in combination. The results showed a weak genotoxicity for three of the four organophosphorous insecticides and for benomyl. The various mixtures did not give additive effects.
authors.affiliation: Institute of Medical Pharmacology, University of Pavia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Bianchi-Santamaria
authors.forename: M
authors.initials: M
authors.lastname: Gobbi
authors.forename: M
authors.initials: M
authors.lastname: Cembran
authors.forename: A
authors.initials: A
authors.lastname: Arnaboldi
mesh_terms: D001387:Azinphosmethyl / Q000633:toxicity; D001542:Benomyl / Q000633:toxicity; D002478:Cells, Cultured; D003976:Diazinon / Q000633:toxicity; D004117:Dimethoate / Q000633:toxicity; D004347:Drug Interactions; D004785:Environmental Pollutants / Q000633:toxicity*; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D015162:Micronucleus Tests; D009946:Organothiophosphorus Compounds / Q000633:toxicity; D010575:Pesticides / Q000633:toxicity*
chemical_list: D004785:Environmental Pollutants; D009946:Organothiophosphorus Compounds; D010575:Pesticides; D001387:Azinphosmethyl; C014153:pirimiphos methyl; D001542:Benomyl; D004117:Dimethoate; D003976:Diazinon