title: Fine mapping of five human skeletal muscle genes: alpha-tropomyosin, beta-tropomyosin, troponin-I slow-twitch, troponin-I fast-twitch, and troponin-C fast.
abstract: In this paper the chromosomal localization of the human skeletal muscle genes Troponin-I slow-twitch (TNNI1), Troponin-I fast-twitch (TNNI2), and Troponin-C fast (TNNC2) and the refinement of the position for alpha-Tropomyosin (TPM1) and beta-Tropomyosin (TPM2) are reported. By radiation hybrid mapping, TPM1 was assigned to chromosome 15q22.1, TPM2 to chromosome 9p13.2-p13.1, TNNI1 to chromosome 1q31.3, TNNI2 to chromosome 11p15.5, and TNNC2 to chromosome 20q12-q13.11. The genomic distribution of these genes is discussed, with particular emphasis on the cluster organization of the Troponin genes.
authors.affiliation: Biology Department, University of Padova, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Tiso
authors.forename: L
authors.initials: L
authors.lastname: Rampoldi
authors.forename: A
authors.initials: A
authors.lastname: Pallavicini
authors.forename: R
authors.initials: R
authors.lastname: Zimbello
authors.forename: D
authors.initials: D
authors.lastname: Pandolfo
authors.forename: G
authors.initials: G
authors.lastname: Valle
authors.forename: G
authors.initials: G
authors.lastname: Lanfranchi
authors.forename: G A
authors.initials: GA
authors.lastname: Danieli
mesh_terms: D001483:Base Sequence; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D002884:Chromosomes, Human, Pair 15; D002890:Chromosomes, Human, Pair 20; D002899:Chromosomes, Human, Pair 9; D017931:DNA Primers; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D018656:Muscle Fibers, Fast-Twitch / Q000378:metabolism; D018657:Muscle Fibers, Slow-Twitch / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D014335:Tropomyosin / Q000096:biosynthesis / Q000235:genetics*; D019209:Troponin C / Q000096:biosynthesis / Q000235:genetics*; D019210:Troponin I / Q000096:biosynthesis / Q000235:genetics*
chemical_list: D017931:DNA Primers; C518658:TNNI2 protein, human; D014335:Tropomyosin; D019209:Troponin C; D019210:Troponin I