Asymptomatic lymphoma associated with elevation of immunoglobulin E.
BACKGROUND
Elevation of immunoglobulin E (IgE) is rarely detected in patients with underlying malignancy. There has been only one report of such a finding in a patient with a T cell lymphoma and none to our knowledge in association with a B-cell lymphoma.


OBJECTIVE
To report a patient with elevation of IgE associated with a B-cell lineage lymphoma.


METHODS
Case report and review of literature.


RESULTS
A 73-year-old woman was found to have elevated IgE (11,766 IU/mL) in a routine evaluation for rhinitis. No underlying allergic diathesis or disease associated with IgE elevation was noted. Because of an abnormal lymphocyte profile, an extensive malignancy evaluation was performed which revealed a B-cell lymphoma.


CONCLUSIONS
B-cell lineage lymphoma can be associated with elevated of IgE and should be included in the differential diagnosis in a patient presenting with this finding.
Koutsonikolis
A
A
Department of Pediatrics, University of South Florida/All Children's Hospital, St. Petersburg, USA.
Day
N
N
Chamizo
W
W
Good
R A
RA
Kornfeld
S J
SJ
D000368:Aged; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology* / Q000473:pathology*; D007073:Immunoglobulin E / Q000097:blood* / Q000276:immunology*; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology*
D007073:Immunoglobulin E