title: Rapid increase of resistance to erythromycin and clindamycin in Streptococcus pyogenes in Italy, 1993-1995. The Italian Surveillance Group for Antimicrobial Resistance.
abstract: A survey of antibiotic resistance in Streptococcus pyogenes in Italy showed a sharp increase in erythromycin resistance. In 1993, the incidence of erythromycin-resistant strains was on average 5.1%, with marked variations by geographic area. Two years later, the incidence of these strains had registered a 1.5- to roughly 20-fold increase, with a mean value of 25.9%, exceeding 40% in three centers out of 13 and 30% in another four. For all the strains studied, normal levels of susceptibility to penicillin were reported.
authors.affiliation: Institute of Microbiology, University of Verona, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Cornaglia
authors.forename: M
authors.initials: M
authors.lastname: Ligozzi
authors.forename: A
authors.initials: A
authors.lastname: Mazzariol
authors.forename: M
authors.initials: M
authors.lastname: Valentini
authors.forename: G
authors.initials: G
authors.lastname: Orefici
authors.forename: R
authors.initials: R
authors.lastname: Fontana
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001426:Bacterial Proteins / Q000276:immunology; D002981:Clindamycin / Q000627:therapeutic use*; D004268:DNA-Binding Proteins / Q000235:genetics; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000627:therapeutic use*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D013290:Streptococcal Infections / Q000188:drug therapy* / Q000453:epidemiology; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000235:genetics / Q000276:immunology; D014157:Transcription Factors / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C086680:ETV5 protein, human; D014157:Transcription Factors; D002981:Clindamycin; D004917:Erythromycin