title: Incidence and characteristics of lymphoid malignancies in untreated myelodysplastic syndromes.
abstract: We have analyzed 1,198 patients with untreated myelodysplastic syndromes (MDS) with two main objectives: (1) to determine the prevalence of lymphoid malignancies (LM) in MDS patients; and (2) to ascertain whether there is some relationship between the MDS subtype and the LM type. In fourteen of 1,198 primary MDS patients (1%) (4 with refractory anemia, 3 with refractory anemia with ring sideroblasts, 2 with refractory anemia with excess of blasts and 5 with chronic myelomonocytic leukemia) a LM was detected. In all cases, the LM was of the B-cell type: 6 cases of chronic lymphocytic leukemia, 5 cases of lymphoplasmacytoid lymphoma, and 3 cases of multiple myeloma. B-cell malignancy did not prevail in any MDS subtype and no correlation was observed between the different varieties of both diseases. In conclusion, in this large series, 1% of the untreated patients with MDS had B-cell malignancy, an association that in most cases is likely to be merely coincidental.
authors.affiliation: Department of Hematology, Hospital L'Aliança Barcelona, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Florensa
authors.forename: T
authors.initials: T
authors.lastname: Vallespí
authors.forename: S
authors.initials: S
authors.lastname: Woessner
authors.forename: A
authors.initials: A
authors.lastname: Domingo
authors.forename: N
authors.initials: N
authors.lastname: Crespo
authors.forename: M
authors.initials: M
authors.lastname: Rozman
authors.forename: J L
authors.initials: JL
authors.lastname: Aguilar
authors.forename: D
authors.initials: D
authors.lastname: Irriguible
authors.forename: A
authors.initials: A
authors.lastname: Zarco
authors.forename: F
authors.initials: F
authors.lastname: Millá
authors.forename: E
authors.initials: E
authors.lastname: Feliu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D015994:Incidence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000453:epidemiology*; D009190:Myelodysplastic Syndromes / Q000150:complications*; D012189:Retrospective Studies