title: [Prognostic risk factors in patients operated on for perforated peptic ulcer. A retrospective analysis of critical factors of mortality and morbidity in a series of 40 patients who underwent simple closure surgery].
abstract: OBJECTIVE
  To identify factors affecting mortality and morbidity in patients operated on for perforated peptic ulcer.
  
  
  METHODS
  Retrospective analysis.
  
  
  METHODS
  University Hospital, Italy.
  
  
  METHODS
  Forty patients consecutively operated on for perforated peptic ulcer by simple suture procedure performed either by laparotomy (n = 26) or laparoscopic (n = 14) approach.
  
  
  RESULTS
  Mortality was 20% (n = 8) and morbidity in survivors was 25% (n = 8). Compared to survivors, non-survivors were older (mean age 79.3 yrs. vs 60.0 yrs., p < 0.01), had worse APACHE II and SAPS scores (mean 20.1 vs 8.5, p < 0.001; and 13.1 vs. 5.5, p < 0.0001 respectively), were treated later (mean interval from outbreak of symptoms to surgery 30.8 hrs. vs. 11.1 hrs., p < 0.01), and the size of their perforation was larger (mean 15.1 mm. vs. 8.6 mm, p < 0.05). The laparoscopic approach was the only factor that significantly was associated with morbidity in survivors (p < 0.01). The presence of at least two risk factors, enhanced the probability of death.
  
  
  CONCLUSIONS
  Old age, great APACHE II and SAPS scores, delay in treatment and large size of the perforation were associated significantly to mortality in perforated peptic ulcer patients. Efforts should be made perioperatively for patients having these risk factors.
authors.affiliation: Dipartimento di Chirurgia, Università degli Studi di Pisa.
authors.forename: M
authors.initials: M
authors.lastname: Chiarugi
authors.forename: P
authors.initials: P
authors.lastname: Buccianti
authors.forename: O
authors.initials: O
authors.lastname: Goletti
authors.forename: L
authors.initials: L
authors.lastname: Decanini
authors.forename: F
authors.initials: F
authors.lastname: Sidoti
authors.forename: E
authors.initials: E
authors.lastname: Cavina
mesh_terms: D018806:APACHE; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D004381:Duodenal Ulcer / Q000150:complications*; D005260:Female; D006801:Humans; D010535:Laparoscopy; D007813:Laparotomy; D008297:Male; D008875:Middle Aged; D010439:Peptic Ulcer Perforation / Q000401:mortality / Q000601:surgery*; D011183:Postoperative Complications; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013276:Stomach Ulcer / Q000150:complications*