title: Visualisation of loss of 5-HT2A receptors with age in healthy volunteers using [18F]altanserin and positron emission tomographic imaging.
abstract: We used [18F]altanserin and positron emission tomography (PET) to image serotonin 5-HT2A receptors in humans. The highest [18F]altanserin uptake is found in the cerebral cortex, with specific-to-nonspecific binding ratios varying from 0.53 to 1.91 in humans between 24 and 48 years of age. In all neocortical regions studied, [18F]altanserin uptake correlates negatively with age. No correlations were found between age and uptake in the cerebellum, the regional cerebral blood flow, or the time course of metabolization of [18F]altanserin. The reduction in cerebral 5-HT2A receptor binding thus directly reflects the loss of specific 5-HT2A receptors with age.
authors.affiliation: Laboratory for Neuro- and Psychophysiology, Medical School, K.U. Leuven, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Rosier
authors.forename: P
authors.initials: P
authors.lastname: Dupont
authors.forename: J
authors.initials: J
authors.lastname: Peuskens
authors.forename: G
authors.initials: G
authors.lastname: Bormans
authors.forename: R
authors.initials: R
authors.lastname: Vandenberghe
authors.forename: M
authors.initials: M
authors.lastname: Maes
authors.forename: T
authors.initials: T
authors.lastname: de Groot
authors.forename: C
authors.initials: C
authors.lastname: Schiepers
authors.forename: A
authors.initials: A
authors.lastname: Verbruggen
authors.forename: L
authors.initials: L
authors.lastname: Mortelmans
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D001921:Brain / Q000000981:diagnostic imaging*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000000981:diagnostic imaging; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D005462:Fluorine Radioisotopes; D006801:Humans; D007650:Ketanserin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D008297:Male; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000502:physiology*; D012016:Reference Values; D012702:Serotonin Antagonists / Q000493:pharmacokinetics*; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C071983:altanserin; D007650:Ketanserin