Diverse molecular interactions of the hnRNP K protein.
The hnRNP K protein is a versatile molecule that interacts with RNA, DNA, the proto-oncoprotein VaV, Src-like tyrosine and inducible serine/threonine kinases, the transcription factor TBP and a number of zinc-finger transcriptional repressors. The interaction of K protein with some of its protein partners is modulated by nucleic acids and K protein can alter the in vivo and in vitro rate of transcription. K protein can simultaneously engage several proteins and may facilitate molecular cross-talk. Taken together these diverse interactions suggest that K protein may act as a nucleic acid-regulated docking platform.
Bomsztyk
K
K
Department of Medicine, University of Washington, Seattle 98195, USA. karolb@u.washington.edu
Van Seuningen
I
I
Suzuki
H
H
Denisenko
O
O
Ostrowski
J
J
D000595:Amino Acid Sequence; D004247:DNA / Q000378:metabolism; D015870:Gene Expression; D034641:Heterogeneous-Nuclear Ribonucleoprotein K; D034441:Heterogeneous-Nuclear Ribonucleoproteins; D006801:Humans; D012313:RNA / Q000378:metabolism; D012261:Ribonucleoproteins / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction
D034641:Heterogeneous-Nuclear Ribonucleoprotein K; D034441:Heterogeneous-Nuclear Ribonucleoproteins; D012261:Ribonucleoproteins; D012313:RNA; D004247:DNA