[Heterogeneity of pores formed in erythrocyte membrane by lipophilic hemolysins].
Concentration dependences of the rate of hemolysis are studied for ascorbic acid, sodium dodecylsulfate, triton X-100, ethyl and butyl alcohols. The double logarithmic plot of this dependence for ascorbic acid presents the straight line with the slope (n) of 2, meaning that two hemolytic molecules are necessary for the formation of one pore in the membrane. Other hemolysins are characterized by the curves with n changing from 2 to 24 as hemolysin concentration increases. The nonlinearity of plots found is considered as a consequence of the heterogeneity of pores, which are formed in the membrane bilayer as hemolysin concentration increases.
Chernitskiĭ
E A
EA
Sen'kovich
O A
OA
Kozlova
N M
NM
D001205:Ascorbic Acid / Q000494:pharmacology; D000440:Butanols / Q000494:pharmacology; D003902:Detergents / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000648:ultrastructure; D000431:Ethanol / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D007700:Kinetics; D017830:Octoxynol / Q000494:pharmacology; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology
D000440:Butanols; D003902:Detergents; D012967:Sodium Dodecyl Sulfate; D000431:Ethanol; D017830:Octoxynol; D001205:Ascorbic Acid
Geterogennost' por, obrazuemykh v membrane éritrotsitov lipofil'nymi gemolitikami.