Localization of genes encoding two human one-domain members of the AAA family: PSMC5 (the thyroid hormone receptor-interacting protein, TRIP1) and PSMC3 (the Tat-binding protein, TBP1).
The eukaryotic genome contains a putative AT-Pase gene family that encodes proteins with one or two highly conserved domain(s) of approximately 230 amino acids. These proteins have diverse cellular functions and mutation in at least one member of the family has been associated with human disease, while mutations in other family members are known to cause cell cycle defects in yeast. Therefore it is of interest to map more family members and so we have localized PSMC5 (the thyroid hormone receptor-interacting protein, TRIP1) and PSMC3 (the Tat-binding protein, TBP1) to chromosomes 17q24-q25 and 11p12-p13, respectively. We also present the map position of a probable PSMC3 processed pseudogene locus on chromosome 9p.
Hoyle
J
J
Neurogenetics Unit, Imperial College School of Medicine at St. Mary's, London, UK.
Tan
K H
KH
Fisher
E M
EM
D000074183:ATPases Associated with Diverse Cellular Activities; D048868:Adaptor Proteins, Signal Transducing; D000251:Adenosine Triphosphatases / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11; D002886:Chromosomes, Human, Pair 17; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D060588:LIM Domain Proteins; D008969:Molecular Sequence Data; D046988:Proteasome Endopeptidase Complex; D014157:Transcription Factors / Q000235:genetics*
D048868:Adaptor Proteins, Signal Transducing; D004268:DNA-Binding Proteins; D060588:LIM Domain Proteins; C092282:PSMC5 protein, human; D014157:Transcription Factors; D046988:Proteasome Endopeptidase Complex; D000251:Adenosine Triphosphatases; D000074183:ATPases Associated with Diverse Cellular Activities; C064757:PSMC3 protein, human