title: Assessment of the functional effect of the intracarotid sodium amobarbital procedure using co-registered MRI/HMPAO-SPECT and SEEG.
abstract: We studied the functional effect of injection of sodium amobarbital (SA) in 10 patients with intractable epilepsy. During the intracarotid amobarbital procedure, we measured delta activity in EEG recording from implanted electrodes and regional cerebral blood flow (rCBF) using HMPAO-SPECT co-registered with MRI. SA injection resulted in an increase in delta activity and a decrease in rCBF in all areas examined. Direct functional changes were observed in structures perfused by the carotid artery injected. In addition, we observed indirect effects, probably owing to deafferentation of neuronal pathways connecting these structures to ipsilateral and contralateral regions, including middle and posterior hippocampus.
authors.affiliation: Montreal Neurological Institute, McGill University, Quebec, Canada.
authors.forename: D
authors.initials: D
authors.lastname: McMackin
authors.forename: F
authors.initials: F
authors.lastname: Dubeau
authors.forename: M
authors.initials: M
authors.lastname: Jones-Gotman
authors.forename: J
authors.initials: J
authors.lastname: Gotman
authors.forename: A
authors.initials: A
authors.lastname: Lukban
authors.forename: G
authors.initials: G
authors.lastname: Dean
authors.forename: A
authors.initials: A
authors.lastname: Evans
authors.forename: D
authors.initials: D
authors.lastname: Tampieri
authors.forename: R
authors.initials: R
authors.lastname: Lisbona
mesh_terms: D000654:Amobarbital / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D001921:Brain / Q000098:blood supply* / Q000187:drug effects*; D002343:Carotid Artery, Internal; D004569:Electroencephalography; D007839:Functional Laterality; D006801:Humans; D007269:Injections, Intra-Arterial; D008279:Magnetic Resonance Imaging; D012039:Regional Blood Flow; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000654:Amobarbital