Nonsteroidal anti-inflammatory drug-induced gastrointestinal toxicity: new insights into an old problem.
Nonsteroidal anti-inflammatory drugs are widely used for the treatment of chronic arthropathies, but their gastrointestinal damage remains a significant limitation to their use. In this review, the pathogenic mechanisms through which these drugs are believed to cause gastrointestinal damage are outlined. A better understanding of the pathogenesis of gastric and intestinal injury has resulted in novel strategies that are being employed to develop nonsteroidal anti-inflammatory drugs that do not have significant adverse effects on the gastrointestinal tract.
Davies
N M
NM
Intestinal Disease Research Unit, Faculty of Medicine, University of Calgary, Alberta, Canada.
Wallace
J L
JL
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D004064:Digestive System / Q000187:drug effects*; D004386:Duodenum / Q000187:drug effects; D006801:Humans; D007421:Intestine, Small / Q000187:drug effects; D013270:Stomach / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal