title: Proton-decoupled 19F spectroscopy of 5-FU catabolites in human liver.
abstract: An RF network and a dual-tuned surface coil are described for obtaining proton-decoupled, NOE enhanced 19F spectra from a whole body clinical imager operating at 1.5 Tesia. The network removes 19F frequency noise from the decoupler transmitter, and prevents preamplifier saturation from high-level decoupling signals. Proton decoupling of 19F spectra was optimized using a sample of urine containing 5-fluorouracil (5-FU) and its catabolite fluoro-beta-alanine (FBAL). Proton-decoupled 19F spectroscopy in vivo is demonstrated by obtaining both nonlocalized spectra and spectra localized with three-dimensional chemical shift imaging from the liver of patients undergoing 5-FU chemotherapy.
authors.affiliation: Department of NMR and Medical Spectroscopy, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. jmurphy@abel.fccc.ed
authors.forename: J
authors.initials: J
authors.lastname: Murphy-Boesch
authors.forename: C W
authors.initials: CW
authors.lastname: Li
authors.forename: L
authors.initials: L
authors.lastname: He
authors.forename: K A
authors.initials: KA
authors.lastname: Padavic-Shaller
authors.forename: W
authors.initials: W
authors.lastname: Negendank
authors.forename: T R
authors.initials: TR
authors.lastname: Brown
mesh_terms: D005472:Fluorouracil / Q000378:metabolism* / Q000627:therapeutic use / Q000652:urine; D006801:Humans; D008099:Liver / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation* / Q000379:methods; D019047:Phantoms, Imaging; D015091:beta-Alanine / Q000031:analogs & derivatives / Q000378:metabolism / Q000652:urine
chemical_list: D015091:beta-Alanine; C032348:alpha-fluoro-beta-alanine; D005472:Fluorouracil