Oral immunoglobulin treatment in Crohn's disease.
Two patients with severe Crohn's disease who failed to respond to traditional medical treatment were given immunoglobulin orally. We used the 6-h urinary recovery of mixture of polyethyleneglycols PEG 400 and 1000 (molecular weight range 282-1250 Da) to test the intestinal permeability. Both patients showed a similar permeability pattern with an increased leakage of large-sized PEGs before treatment and a lower urinary recovery of probes after treatment with immunoglobulin. This might indicate that the inflammatory process in Crohn's disease can be affected from the luminal side of the mucosa.
Tjellström
B
B
Department of Paediatrics, Norrköping Hospital, Sweden.
Stenhammar
L
L
Magnusson
K E
KE
Sandqvist
T
T
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D003424:Crohn Disease / Q000628:therapy*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage*; D011092:Polyethylene Glycols / Q000008:administration & dosage
D007136:Immunoglobulins; D011092:Polyethylene Glycols