[The effect of picrotoxin-induced seizure activity on the cAMP-dependent phosphorylation of synapsin-I in rats].
Picrotoxin administration decreased the incorporation of labelled phosphate in neurospecific protein synapsin I in vitro in cortex. In the animal hippocampus, the incorporation was more expressed. The data obtained suggest that activation of the cAMP-dependent phosphorylation occurs during seizure in the cortex.
Arkhipov
V I
VI
Shilakina
T G
TG
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism; D003292:Convulsants; D000242:Cyclic AMP / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D010761:Phosphorus Radioisotopes; D010766:Phosphorylation / Q000187:drug effects; D010852:Picrotoxin; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism*; D016704:Synapsins / Q000378:metabolism*; D013574:Synaptosomes / Q000378:metabolism
D003292:Convulsants; D000242:Cyclic AMP; D010761:Phosphorus Radioisotopes; D010852:Picrotoxin; D016704:Synapsins
Vliianie sudorozhnoĭ aktivnosti, indutsirovannoĭ pikrotoksinom, na tsAMF-zavisimoe fosforilirovanie sinapsina-1 u krys.