[Immune complexes induce the secretion of Th2 cytokines in human monocytes].
Two experimental models of immune complexes were used to study the secretion of interleukin (IL)-10, IL-6, IL-1 beta and TNF-alpha by human monocytes in vitro. Immune complexes formed of tetanus toxoid and polyclonal anti-tetanus toxoid antiserum as well as heat-aggregated human serum immunoglobulins induced the release of IL-6 and IL-10 in a dose- and antigen: antibody ratio-dependent manner. Antigen-antibody complexes formed near equivalence were most effective in induction of a cytokine response. Additionally, we demonstrated that endogenously synthesized IL-10 limited the immune complex-induced secretion of proinflammatory cytokines tumor necrosis factor-alpha, IL-6 and IL-1 beta. IL-10 is an anti-inflammatory cytokine and closely associated with the T helper type 2 (Th2) immune response. We conclude that immune complexes, besides their well known ability to cause acute and chronic inflammation, can mediate immunosuppressive effects and influence the balance of Th1/ Th2 responses.
Berger
S
S
Institut für Pathologie, Klinikum, Johann Wolfgang Goethe Universität, Frankfurt/M.
Balló
H
H
Stutte
H J
HJ
D000936:Antigen-Antibody Complex; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis* / Q000378:metabolism; D006801:Humans; D007106:Immune Sera; D007074:Immunoglobulin G; D016753:Interleukin-10 / Q000096:biosynthesis; D009000:Monocytes / Q000276:immunology*; D013745:Tetanus Toxoid / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology*
D000936:Antigen-Antibody Complex; D016207:Cytokines; D007106:Immune Sera; D007074:Immunoglobulin G; D013745:Tetanus Toxoid; D016753:Interleukin-10
Immunkomplexe induzieren die Sekretion von Th2-Zytokinen in humanen Monozyten.