title: Activation of microglial and endothelial cells in the rat brain after treatment with interferon-gamma in vivo.
abstract: Activation of microglial cells occurs during the pathogenesis of various neurologic diseases. However, the mechanisms of activation in vivo are still elusive. We infused adult rats intravenously with interferon-gamma and demonstrated microglial cell activation after three days of treatment. We show for the first time that microglial cells proliferate inside the brain in response to a circulating cytokine. Microglial cells were induced to express major histocompatibility (MHC) class I and class II antigens and small amounts of leukocyte function-associated molecule 1 (LFA-1, CD11a). On endothelial cells of the brain, MHC class I and class II antigens and intercellular adhesion molecule 1 (ICAM-1, CD54) were enhanced.
authors.affiliation: Institute of Anatomy and Cell Biology, Philipps University Marburg, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Grau
authors.forename: B
authors.initials: B
authors.lastname: Herbst
authors.forename: P H
authors.initials: PH
authors.lastname: van der Meide
authors.forename: B
authors.initials: B
authors.lastname: Steiniger
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000187:drug effects*; D002452:Cell Count; D002455:Cell Division; D002540:Cerebral Cortex / Q000166:cytology; D004730:Endothelium, Vascular / Q000187:drug effects*; D007371:Interferon-gamma / Q000494:pharmacology*; D007962:Leukocytes / Q000166:cytology; D008297:Male; D017628:Microglia / Q000187:drug effects*; D010641:Phenotype; D051381:Rats; D011917:Rats, Inbred Lew; D011994:Recombinant Proteins
chemical_list: D011994:Recombinant Proteins; D007371:Interferon-gamma