title: Genetic analysis of the larval optic nerve projection in Drosophila.
abstract: The Drosophila larval optic nerve, called Bolwig's nerve (BN), projects into the central brain along a simple invariant path. The growth of the BN proceeds in three phases, during which the nerve changes direction at two intermediate targets, P1 and P2. Here we show that the projection of the BN is amenable to genetic dissection. In a mutagenesis screen, we have isolated mutations in 13 genes that disrupt the BN projection in distinct phases of its development. The mutant phenotypes in combination with the expression patterns of corresponding candidate genes define cellular components necessary for directing the growth of the BN toward P2 and for redirecting its growth at P2, and reveal developmental strategies employed in the establishment of the BN projection.
authors.affiliation: Rockefeller University, Laboratory of Developmental Neurogenetics, New York, NY 10021, USA.
authors.forename: D
authors.initials: D
authors.lastname: Schmucker
authors.forename: H
authors.initials: H
authors.lastname: Jäckle
authors.forename: U
authors.initials: U
authors.lastname: Gaul
mesh_terms: D000483:Alleles; D000818:Animals; D001370:Axonal Transport / Q000235:genetics; D004268:DNA-Binding Proteins; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D029721:Drosophila Proteins; D005819:Genetic Markers; D007814:Larva / Q000737:chemistry / Q000235:genetics; D016296:Mutagenesis; D009419:Nerve Tissue Proteins; D009900:Optic Nerve / Q000737:chemistry* / Q000196:embryology; D011518:Proto-Oncogene Proteins / Q000235:genetics; D014157:Transcription Factors
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D005819:Genetic Markers; D009419:Nerve Tissue Proteins; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors; C083884:pnt protein, Drosophila