[Acute band-shaped keratopathy after intraocular fibrinolysis with recombinant tissue plasminogen activator (rt-PA)].
BACKGROUND
Intraocular fibrinolysis with recombinant tissue-plasminogen activator (rt-PA) in patients with severe fibrin reactions following anterior segment surgery is widely accepted because of the low complication rate.


METHODS
We present two eyes of two patients developing acute bandkeratopathy within the first week after intraocular rt-PA fibrinolysis (10 mg/100 ml). In the first patient, calcium deposition occurred inferiorly of the optic axis without visual impairment. In the second patient, a dense bandkeratopathy reaching from limbus to limbus developed, with a severe decrease of vision. A corneal abrasion together with the chelating agent disodium ethylene diamine tetra-acetate (EDTA) 0.5% in neutral solution led only to an incomplete resolution of the depositions.


CONCLUSIONS
Acute development of a bandkeratopathy is very rare. Several risk factors are identified so far, e.g. the use of phosphate containing eye drops. Their interactions and the possible pathomechanism are discussed in detail. The close coincidence of intraocular rt-PA fibrinolysis and acute band-keratopathy in our two patients is in favor of an at least additive causative role of rt-PA fibrinolysis. Therefore, the indication should be limited to severe fibrin reactions and local application of phosphate containing drugs should be avoided.
Althaus
C
C
Augenklinik, Heinrich-Heine-Universität Düsseldorf.
Schelle
C
C
Sundmacher
R
R
D000368:Aged; D000369:Aged, 80 and over; D003318:Corneal Opacity / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D005337:Fibrin / Q000378:metabolism*; D006801:Humans; D007910:Lenses, Intraocular; D011183:Postoperative Complications / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D010959:Tissue Plasminogen Activator / Q000009:adverse effects* / Q000627:therapeutic use
D011994:Recombinant Proteins; D005337:Fibrin; D010959:Tissue Plasminogen Activator
Akute bandförmige Keratopathie nach intraokularer Fibrinolyse mit rekombinantem Tissue-Plasminogen-Aktivator (rt-PA).