title: Individual and combined effects of moniliformin present in Fusarium fujikuroi culture material and aflatoxin in broiler chicks.
abstract: The individual and combined effects of feeding diets containing 100 mg moniliformin (M) and 3.5 mg aflatoxins (AF)/kg of diet were evaluated in male broiler chicks from day of hatch to 3 wk of age. When compared with controls, BW gains were reduced 29% by M, 13% by AF, and 33% by the M and AF combination. The efficiency of feed utilization was adversely affected by M independent of AF. Feeding M resulted in decreased relative weights of the bursa of Fabricius and increased relative weights of the heart, increased serum concentrations of creatinine and calcium, increased activities of alkaline phosphatase and alanine aminotransferase, and changes in hematological values. Feeding AF resulted in increased relative weights of the kidney and heart, decreased serum concentrations of total protein, albumin, cholesterol, and calcium, and decreased mean corpuscular volume. Feeding the combination of M and AF resulted in increased relative weights of the heart, decreased serum concentrations of total protein, albumin, and inorganic phosphorus, increased concentrations of creatinine and activity of alanine aminotransferase, and changes in hematological values. Results indicate additive or less than additive toxicity, but not toxic synergy, for most parameters when chicks are fed diets containing the combination of 100 mg M and 3.5 mg AF/kg of diet. The likelihood of encountering these high concentrations of these mycotoxins in finished feed is small; however, additional data on the naturally occurring concentrations of M are necessary before the importance of this mycotoxin to the poultry industry can be assessed.
authors.affiliation: USDA, Agricultural Research Service, College Station, Texas 77845, USA.
authors.forename: L F
authors.initials: LF
authors.lastname: Kubena
authors.forename: R B
authors.initials: RB
authors.lastname: Harvey
authors.forename: S A
authors.initials: SA
authors.lastname: Buckley
authors.forename: T S
authors.initials: TS
authors.lastname: Edrington
authors.forename: G E
authors.initials: GE
authors.lastname: Rottinghaus
mesh_terms: D000348:Aflatoxins / Q000008:administration & dosage / Q000633:toxicity*; D000410:Alanine Transaminase / Q000097:blood; D000821:Animal Feed; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects*; D002060:Bursa of Fabricius / Q000033:anatomy & histology / Q000187:drug effects; D002118:Calcium / Q000097:blood; D002645:Chickens; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D003503:Cyclobutanes / Q000008:administration & dosage / Q000633:toxicity*; D004347:Drug Interactions; D004734:Energy Metabolism / Q000187:drug effects; D005670:Fusarium; D006321:Heart / Q000033:anatomy & histology / Q000187:drug effects; D007668:Kidney / Q000033:anatomy & histology / Q000187:drug effects; D008297:Male; D009183:Mycotoxins / Q000008:administration & dosage / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects
chemical_list: D000348:Aflatoxins; D001798:Blood Proteins; D003503:Cyclobutanes; D009183:Mycotoxins; C008539:moniliformin; D002784:Cholesterol; D003404:Creatinine; D000410:Alanine Transaminase; D002118:Calcium