Effect of monochlorohydrins of linoleic acid on guinea-pig cardiac papillary muscles.
The hydrogen peroxide (H2O2)-myeloperoxidase system can convert linoleic acid (LA) to monochlorohydrins. LA monochlorohydrins can also be produced when LA monoepoxides are subjected to low pH solutions. We chemically synthesized and purified LA monochlorohydrins and examined their effect on the developed tension of guinea-pig papillary muscles in vitro in terms of both concentration and the duration of exposure. A decrease in muscular tension was observed immediately after addition of LA monochlorohydrins at concentrations of 30, 100, and 300 microM. We also compared the effect of LA monochlorohydrins on muscle tension with those of LA monoepoxides.
Iwase
H
H
Department of Forensic Medicine, Faculty of Medicine, University of Tokyo, Japan.
Yamada
Y
Y
Uemura
H
H
Nakaya
H
H
Takatori
T
T
Nagao
M
M
Iwadate
K
K
D000818:Animals; D002728:Chlorohydrins / Q000032:analysis / Q000494:pharmacology*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000737:chemistry*; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000737:chemistry; D051381:Rats
D002728:Chlorohydrins; D008041:Linoleic Acids; D019787:Linoleic Acid