A multicenter clinical trial of a biosynthetic skin replacement, Dermagraft-TC, compared with cryopreserved human cadaver skin for temporary coverage of excised burn wounds.
This multicenter study compared the use of a biosynthetic human skin substitute with frozen human cadaver allograft for the temporary closure of excised burn wounds. Dermagraft-TC (Advanced Tissue Sciences, Inc.) (DG-TC) consists of a synthetic material onto which human neonatal fibroblasts are cultured. Burn wounds in 66 patients with a mean age of 36 years and a mean burn size of 44% total body surface area (28% total body surface area full-thickness) were surgically excised. Two comparable sites, each approximately 1% total body surface area in size, were randomized to receive either DG-TC or allograft. Both sites were then treated in the same manner. When clinically indicated (> 5 days after application) both skin replacements were removed, and the wound beds were evaluated and prepared for grafting. DG-TC was equivalent or superior to allograft with regard to autograft take at postautograft day 14. DG-TC was also easier to remove, had no epidermal slough, and resulted in less bleeding than did allograft while maintaining an adequate wound bed. Overall satisfaction was better with DG-TC.
Purdue
G F
GF
Department of Surgery, University of Texas, Southwestern Medical Center, Dallas 75235-9031, USA.
Hunt
J L
JL
Still
J M
JM
Law
E J
EJ
Herndon
D N
DN
Goldfarb
I W
IW
Schiller
W R
WR
Hansbrough
J F
JF
Hickerson
W L
WL
Himel
H N
HN
Kealey
G P
GP
Twomey
J
J
Missavage
A E
AE
Solem
L D
LD
Davis
M
M
Totoritis
M
M
Gentzkow
G D
GD
D000328:Adult; D002056:Burns / Q000601:surgery*; D002102:Cadaver; D015925:Cryopreservation; D005260:Female; D006801:Humans; D008297:Male; D016038:Skin Transplantation; D017768:Skin, Artificial; D014184:Transplantation, Homologous; D014945:Wound Healing; D014946:Wound Infection