Cytochrome P450 2E1 polymorphism as a risk factor for lung cancer: in relation to p53 gene mutation.
The distribution of cytochrome P450 2E1 (CYP2E1) genetic polymorphism was compared in 126 patients with non-small cell lung cancer (NSCLC) and 612 control subjects by PCR-based assay. Incidence of C type (c2/c2) of CYP2E1 polymorphism in the patients with squamous cell carcinoma (9.4%) was significantly higher than that in healthy controls (4.1%) or in the patients with adenocarcinoma (2.7%) within the Japanese population. The relative risk (95% confidence limit) of C type compared with A and B type in patients with squamous cell carcinoma was 2.45 (0.92-6.48). The incidence of p53 gene mutation was studied in an association with CYP2E1 polymorphism. When all the NSCLC patients were considered, the incidence of p53 mutations in type C (85.7%) was significantly higher than that of A and B type (32.8%). It is suggested that C type of CYP2E1 may define individuals at an increased risk of squamous cell carcinoma through the impaired metabolism of a certain carcinogen which predisposes to p53 gene mutation.
Oyama
T
T
Department of Surgery II, School of Medicine, Kitakyushu, Japan.
Kawamoto
T
T
Mizoue
T
T
Sugio
K
K
Kodama
Y
Y
Mitsudomi
T
T
Yasumoto
K
K
D000230:Adenocarcinoma / Q000201:enzymology* / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000201:enzymology* / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000235:genetics*; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
D019392:Cytochrome P-450 CYP2E1