title: Management of twin pregnancies discordant for anencephaly.
abstract: OBJECTIVE
  To examine options of management and outcome of twin pregnancies discordant for anencephaly.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Research Centre for Fetal Medicine.
  
  
  METHODS
  Twenty-four twin pregnancies discordant for anencephaly.
  
  
  METHODS
  A computer search was made of our database for twin pregnancies discordant for anencephaly. The data were reviewed for gestation at presentation, chorionicity, management and pregnancy outcome.
  
  
  METHODS
  Pregnancy outcome in relation to chorionicity and management.
  
  
  RESULTS
  There were 13 dichorionic and 11 monochorionic twin pregnancies discordant for anencephaly. In the dichorionic group five pregnancies had selective fetocide at 17 to 21 weeks; one pregnancy resulted in spontaneous abortion but in the others a healthy infant was born at a median gestation of 37 weeks. The other eight dichorionic pregnancies were managed expectantly, but three developed polyhydramios at 26 to 30 weeks; in one case amniodrainage was performed and in another selective fetocide was carried out. In this group the median gestation at delivery was 35 weeks. All 11 monochorionic pregnancies were managed expectantly and in three there was intrauterine death of both fetuses. In the other eight cases the normal twin was liveborn at a median gestation of 34 weeks; in four of these pregnancies polyhydramnios developed and two were managed by amniodrainage.
  
  
  CONCLUSIONS
  In monochorionic pregnancies, expectant management is associated with a high rate of intrauterine lethality of the normal twin. In dichorionic pregnancies selective fetocide in the second trimester prevents the development of polyhydramnios and is associated with a lower risk of preterm delivery but can cause miscarriage.
authors.affiliation: Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, Medical School, London, UK.
authors.forename: N J
authors.initials: NJ
authors.lastname: Sebire
authors.forename: W
authors.initials: W
authors.lastname: Sepulveda
authors.forename: K S
authors.initials: KS
authors.lastname: Hughes
authors.forename: P
authors.initials: P
authors.lastname: Noble
authors.forename: K H
authors.initials: KH
authors.lastname: Nicolaides
mesh_terms: D000757:Anencephaly / Q000628:therapy*; D002585:Cesarean Section; D005260:Female; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D018607:Pregnancy Reduction, Multifetal; D012189:Retrospective Studies; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic