title: Levels of stem cell factor and interleukin-3 in serum in acute Plasmodium falciparum malaria.
abstract: The purpose of the present study was to measure serum concentrations of stem cell factor (SCF) and interleukin-3 (IL-3) in patients with acute Plasmodium falciparum malaria. Serum samples from 15 patients were taken on day of admission and days 7, 14, 21, and 28. Anemia developed in 80% of patients. A transient increase in IL-3 could be observed at the beginning of the disease. It remains controversial whether the measured concentrations of IL-3 and SCF correlate with the grade of anemia. The possibly suppressed IL-3 and SCF production may contribute to the prolonged anemia in P. falciparum malaria, as has been shown for erythropoietin.
authors.affiliation: Department of Internal Medicine I, University of Vienna, Austria.
authors.forename: H
authors.initials: H
authors.lastname: Burgmann
authors.forename: S
authors.initials: S
authors.lastname: Looareesuwan
authors.forename: E C
authors.initials: EC
authors.lastname: Wiesinger
authors.forename: W
authors.initials: W
authors.lastname: Winter
authors.forename: W
authors.initials: W
authors.lastname: Graninger
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000740:Anemia / Q000097:blood / Q000209:etiology*; D016022:Case-Control Studies; D004920:Erythropoiesis; D005260:Female; D006400:Hematocrit; D006801:Humans; D007377:Interleukin-3 / Q000097:blood*; D016778:Malaria, Falciparum / Q000097:blood* / Q000150:complications* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D019089:Stem Cell Factor / Q000097:blood*
chemical_list: D007377:Interleukin-3; D019089:Stem Cell Factor