title: Potential preventive effects of Chelidonium majis L. (Papaveraceae) herb extract on glandular stomach tumor development in rats treated with N-methyl-N'-nitro-N nitrosoguanidine (MNNG) and hypertonic sodium chloride.
abstract: The modifying effects of Chelidonium majis L. (Papaveraceae) herb extract (CH), an analgesic traditionally prescribed for gastric and duodenal ulcer patients, on gastric tumor development were studied in rats given N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Sixty-four male 6-week-old Wistar rats were used. Group 1 rats were initially given MNNG (200 mg/kg b.w.) by gavage at days 0 and 14 as well as saturated sodium chloride solution (S-NaCl, 1 ml per rat) every 3 days during weeks 0-3 (six times), and then placed on basal diet containing 0.1 or 0.2% CH for 16 weeks from week 4. Rats of Group 2 and 3 were treated with MNNG together with S-NaCl or saline (0.9% NaCl, 1 ml per rat), respectively, timed as in Group 1 but without further treatment. All surviving animals were killed at week 20 and histopathologically investigated. In the glandular stomach, the number of preneoplastic pepsinogen 1 altered pyloric glands (PAPGs) in the MNNG + S-NaCl-->CH (0.1%) group (Group 1) was significantly smaller than in the MNNG + S-NaCl group (Group 2) (P < 0.02). The incidences of forestomach neoplastic lesions (papillomas and squamous cell carcinomas) also showed a tendency to decrease with the CH treatment. The results thus indicate that CH exerts inhibitory effects on glandular stomach carcinogenesis in the rat, so that it may have potential as a chemopreventive agent for stomach cancer in man.
authors.affiliation: Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan.
authors.forename: D J
authors.initials: DJ
authors.lastname: Kim
authors.forename: B
authors.initials: B
authors.lastname: Ahn
authors.forename: B S
authors.initials: BS
authors.lastname: Han
authors.forename: H
authors.initials: H
authors.lastname: Tsuda
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens / Q000633:toxicity*; D003043:Cocarcinogenesis; D006965:Hyperplasia; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D010435:Pepsinogens; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal; D011230:Precancerous Conditions / Q000139:chemically induced / Q000517:prevention & control; D011706:Pyloric Antrum; D051381:Rats; D017208:Rats, Wistar; D012462:Saline Solution, Hypertonic / Q000633:toxicity*; D013270:Stomach / Q000187:drug effects / Q000473:pathology; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000517:prevention & control*
chemical_list: D016588:Anticarcinogenic Agents; D002273:Carcinogens; D010435:Pepsinogens; D010936:Plant Extracts; D012462:Saline Solution, Hypertonic; D008769:Methylnitronitrosoguanidine