The mythology of hormone replacement therapy.
OBJECTIVE
To evaluate the literature on contraindications contained in pharmaceutical data sheets of five currently available oestrogen replacement preparations (HRT). These contraindications include cardiovascular disease, diabetes, liver diseases, otosclerosis, endometriosis, melanoma and hormone-dependent tumours.


METHODS
Systematic review.


METHODS
Oestrogen replacement regimens.


RESULTS
The contraindications to the five HRT preparations have been taken uncritically from the data sheets of oral contraceptives. In some of these conditions not only is HRT not contraindicated, it is indicated. The data sheets for the HRT preparations all state that cardiovascular disease is a contraindication, but systematic review shows that ischaemic heart disease, hypertension and hyperlipidaemia are not contraindications, and in ischaemic heart disease HRT may actually be indicated. Similarly, systematic review shows that diabetes, chronic liver disease, endometriosis, some cases of treated cancer of the endometrium and breast, melanoma and otosclerosis are not contraindications to HRT.


CONCLUSIONS
The information in the pharmaceutical data sheets of HRT regimens should be modified as more accurate information could influence how these preparations are prescribed by doctors as well as affect patient compliance.
Hartmann
B W
BW
Department of Special Gynaecology, General Hospital, University of Vienna, Austria.
Huber
J C
JC
D001943:Breast Neoplasms / Q000150:complications; D002318:Cardiovascular Diseases / Q000150:complications; D000075202:Contraindications; D048909:Diabetes Complications; D004715:Endometriosis / Q000150:complications; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000150:complications; D008545:Melanoma / Q000150:complications; D009376:Neoplasms, Hormone-Dependent / Q000150:complications; D010040:Otosclerosis / Q000150:complications