Effect of angiotensin-converting enzyme inhibitors on fructose induced hypertension and hyperinsulinaemia in rats.
1. The effect of angiotensin-converting enzyme inhibitors (ACEI) enalapril, lisinopril and ramipril was studied on fructose-induced hypertensive and hyperinsulinaemic rats. 2. 60 Sprague-Dawley rats were fed a fructose-enriched diet for 5 weeks, which produced hyperinsulinaemia, hypertriglyceridaemia and hypertension. Beginning with week 3 of the diet, lisinopril (10 and 20 mg per kg per day), ramipril (5 and 10 mg/kg per day) and enalapril (20 mg/kg per day) were given daily in drinking water for 2 weeks to 10 rats in each drug group. Ten rats fed only the fructose-enriched diet served as control. 3. Systolic blood pressure was measured weekly by the indirect tail-cuff method. Plasma insulin level was determined using RIA. 4. Data indicate that ACEI improve insulin resistance induced by high-fructose intake in rats; that despite their equal hypotensive effect, ACEI differ in their ability to improve insulin resistance; and that improvement of insulin resistance by ACEI is dose-dependent.
Erlich
Y
Y
Chorley Institute of Hypertension, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Rosenthal
T
T
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004032:Diet; D005632:Fructose; D006946:Hyperinsulinism / Q000139:chemically induced / Q000517:prevention & control*; D006973:Hypertension / Q000139:chemically induced / Q000517:prevention & control*; D007328:Insulin / Q000097:blood; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
D000806:Angiotensin-Converting Enzyme Inhibitors; D007328:Insulin; D014280:Triglycerides; D005632:Fructose