Role of serum interleukin-8 and intercellular adhesion molecule-1 in the severity of alcoholic hepatitis.
Among patients with alcoholic hepatitis, three groups were distinguished by histological findings and clinico-pathological features. The aim of this study was to clarify the role of soluble intercellular adhesion molecule-1 (sICAM-1) and interleukin-8 (IL-8) in the development of severe alcoholic hepatitis. The levels of sICAM-1 and IL-8 were well correlated with the severity of liver injuries. The concentrations of serum IL-8 were significantly correlated with the number of polymorphonuclear leukocytes infiltrating the liver. Serial determination of these two markers revealed that IL-8 may be complementary in assessing the severity and prognosis of alcoholic hepatitis.
Ishii
K
K
Second Department of Medicine, Kurume University School of Medicine, Japan.
Furudera
S
S
Kumashiro
R
R
Seo
J
J
Koga
Y
Y
Sata
M
M
Tanikawa
K
K
D000328:Adult; D015815:Cell Adhesion Molecules; D005260:Female; D006519:Hepatitis, Alcoholic / Q000097:blood*; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D011379:Prognosis; D012720:Severity of Illness Index; D014409:Tumor Necrosis Factor-alpha
D015815:Cell Adhesion Molecules; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha