Argenteanones C-E and argenteanols B-E, cytotoxic cycloartanes from Aglaia argentea.
Seven new cycloartanes, argenteanones C-E (4-6) and argenteanols B-E (7-10), have been isolated from Aglaia argentea leaves. All of these compounds possess significant cytotoxic activity against KB cells (IC50 values between 3.7 and 6.2 micrograms/mL). Structure elucidation was performed by 2D NMR spectroscopy, aided by molecular modeling in the case of the side chain of compound 7.
Mohamad
K
K
Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France.
Martin
M T
MT
Leroy
E
E
Tempête
C
C
Sévenet
T
T
Awang
K
K
Païs
M
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D018515:Plant Leaves / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism; D014315:Triterpenes; D014407:Tumor Cells, Cultured
D012503:Saponins; D014315:Triterpenes; C085352:cycloartane