title: The effect of mode of administration on medical outcomes study health ratings and EuroQol scores in AIDS.
abstract: Brief measures of health-related quality of life are being used with increased frequency in AIDS clinical trials. Self-administration of questionnaires can reduce costs in this setting because they require little time. However, the equivalence between self- and interview-administered responses in clinical trials is not known. We evaluated patient and proxy responses to the Medical Outcomes Study HIV Health Survey (MOS-HIV) and the EuroQol. We randomized 68 patients with advanced HIV disease on (1) mode of administration (self vs. interview); (2) type of interview (face-to-face vs. telephone); (3) questionnaire order (MOS-first vs. EuroQol-first); and (4) 2- vs. 3-item response categories for physical limitations. There were few differences in scores between self and interview administration and type of interview. Proxy respondents viewed patients as more impaired than did patients themselves on subjective aspects of health including mental health (63.8 vs. 75.7, p < 0.001), health distress (67.3 vs. 77.1, p = 0.007), pain (64.4 vs. 70.0, p = 0.04), and vitality (48.4 vs. 55.5, p = 0.04). Results concerning questionnaire order and number of response categories were not conclusive. Our results suggest that for patients with advanced HIV disease, data from the MOS-HIV and the EuroQol collected using different modes may be pooled, but that proxy responses should be calibrated.
authors.affiliation: School of Hygiene and Public Health, Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: A W
authors.initials: AW
authors.lastname: Wu
authors.forename: D L
authors.initials: DL
authors.lastname: Jacobson
authors.forename: R A
authors.initials: RA
authors.lastname: Berzon
authors.forename: D A
authors.initials: DA
authors.lastname: Revicki
authors.forename: C
authors.initials: C
authors.lastname: van der Horst
authors.forename: C J
authors.initials: CJ
authors.lastname: Fichtenbaum
authors.forename: M S
authors.initials: MS
authors.lastname: Saag
authors.forename: L
authors.initials: L
authors.lastname: Lynn
authors.forename: D
authors.initials: D
authors.lastname: Hardy
authors.forename: J
authors.initials: J
authors.lastname: Feinberg
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D015658:HIV Infections / Q000523:psychology*; D006302:Health Services Research; D006304:Health Status; D006306:Health Surveys; D006801:Humans; D007407:Interviews as Topic / Q000379:methods*; D008297:Male; D011788:Quality of Life; D011795:Surveys and Questionnaires