Nociceptin: an endogenous agonist for central opioid like1 (ORL1) receptors possesses systemic vasorelaxant properties.
The purpose of the present study was to investigate the effects of nociceptin on peripheral arterial rings from the cat. When feline renal, mesenteric, carotid and femoral rings with intact endothelium were precontracted with phenylephrine (100 nanomolar), nociceptin (3 x 10(-11)-3 x 10(-6) M) decreased tension in a concentration-dependent manner. The present data suggest nociceptin possesses biologic activity outside the CNS and may contribute to the regulation of systemic blood pressure and regional blood flow.
Gumusel
B
B
HL Labs, Inc., New Orleans, LA 70112, USA.
Hao
Q
Q
Hyman
A
A
Chang
J K
JK
Kapusta
D R
DR
Lippton
H
H
D000818:Animals; D001158:Arteries / Q000502:physiology*; D002415:Cats; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D018847:Opioid Peptides / Q000502:physiology*; D011957:Receptors, Opioid / Q000819:agonists*; D014664:Vasodilation / Q000502:physiology*; D000097629:Nociceptin
D018847:Opioid Peptides; D011957:Receptors, Opioid; D000097629:Nociceptin