Proton-decoupled 19F spectroscopy of 5-FU catabolites in human liver.
An RF network and a dual-tuned surface coil are described for obtaining proton-decoupled, NOE enhanced 19F spectra from a whole body clinical imager operating at 1.5 Tesia. The network removes 19F frequency noise from the decoupler transmitter, and prevents preamplifier saturation from high-level decoupling signals. Proton decoupling of 19F spectra was optimized using a sample of urine containing 5-fluorouracil (5-FU) and its catabolite fluoro-beta-alanine (FBAL). Proton-decoupled 19F spectroscopy in vivo is demonstrated by obtaining both nonlocalized spectra and spectra localized with three-dimensional chemical shift imaging from the liver of patients undergoing 5-FU chemotherapy.
Murphy-Boesch
J
J
Department of NMR and Medical Spectroscopy, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. jmurphy@abel.fccc.ed
Li
C W
CW
He
L
L
Padavic-Shaller
K A
KA
Negendank
W
W
Brown
T R
TR
D005472:Fluorouracil / Q000378:metabolism* / Q000627:therapeutic use / Q000652:urine; D006801:Humans; D008099:Liver / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation* / Q000379:methods; D019047:Phantoms, Imaging; D015091:beta-Alanine / Q000031:analogs & derivatives / Q000378:metabolism / Q000652:urine
D015091:beta-Alanine; C032348:alpha-fluoro-beta-alanine; D005472:Fluorouracil