Inhibition of human class 3 aldehyde dehydrogenase, and sensitization of tumor cells that express significant amounts of this enzyme to oxazaphosphorines, by the naturally occurring compound gossypol.
Rekha
G K
GK
Department of Pharmacology, University of Minnesota Medical School, Minneapolis 55455, USA.
Sladek
N E
NE
D000230:Adenocarcinoma; D000444:Aldehyde Dehydrogenase / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D018906:Antineoplastic Agents, Alkylating / Q000633:toxicity*; D001943:Breast Neoplasms; D002396:Catechols / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects*; D003520:Cyclophosphamide / Q000031:analogs & derivatives* / Q000633:toxicity; D004790:Enzyme Induction; D005260:Female; D005753:Gastric Mucosa / Q000201:enzymology; D006072:Gossypol / Q000633:toxicity*; D006801:Humans; D007700:Kinetics; D010752:Phosphoramide Mustards / Q000633:toxicity*; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D013379:Substrate Specificity; D014407:Tumor Cells, Cultured
D018906:Antineoplastic Agents, Alkylating; D002396:Catechols; D010752:Phosphoramide Mustards; D011994:Recombinant Proteins; C030863:corneal protein 54, bovine; C030090:phosphoramide mustard; C048341:mafosfamide; D003520:Cyclophosphamide; D000444:Aldehyde Dehydrogenase; D006072:Gossypol; C034221:catechol