Microsomal and peroxisomal fatty acid oxidation in streptozotocin diabetic rat liver.
Microsomal lauric acid hydroxylation and fatty acid peroxisomal beta-oxidation were studied in hepatic subcellulant preparations from streptozotocin-induced diabetic and diabetic insulin-treated rats. 2. The liver microsomes of the streptozotocin diabetic rats displayed a similar activity to hydroxylate lauric acid as the control microsomes. 3. Diabetic insulin-treated rats showed lower (omega 1) and omega-lauric acid hydroxylase activities than diabetic and control rats. 4. Streptozotocin-induced diabetes and diabetic insulin-treated rats exhibited no significant changes on peroxisomal palmitoyl CoA beta-oxidation compared to the control rats. 5. Both microsomal and peroxisomal fatty acid oxidation responded in a similar way in this model of experimental diabetes.
Orellana
M
M
Department of Biochemistry, Faculty of Medicine, University of Chile, Santiago, Chile.
Valdés
E
E
Del Villar
E
E
D000818:Animals; D001835:Body Weight; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism*; D007328:Insulin / Q000627:therapeutic use; D007850:Lauric Acids / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008830:Microbodies / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism*; D009929:Organ Size; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
D007328:Insulin; D007850:Lauric Acids; C030358:lauric acid; D013311:Streptozocin; D003577:Cytochrome P-450 Enzyme System