Estradiol and progesterone release form biodegradable d,l-lactide and epsilon-caprolactone copolymer.
A study on the release of 17 beta-estradiol and progesterone from d,l-lactide and epsilon-caprolactone copolymer was performed. The copolymer was used in the form of microsphere, d,l-lactide content in the copolymer was 83%. It was found that nearly constant rate of hormone release during 100 days of experiment can be achieved by using this biodegradable material as a drug carrier.
Nowak
M
M
Department of Pathophysiology, Silesian University School of Medicine, Poland.
Buntner
B
B
Bero
M
M
Górski
J
J
Kajdaniuk
D
D
Głogowska-Szelag
J
J
Plewka
A
A
D000818:Animals; D001711:Biotransformation; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004958:Estradiol / Q000008:administration & dosage* / Q000032:analysis / Q000493:pharmacokinetics; D008297:Male; D008863:Microspheres; D011091:Polyesters / Q000493:pharmacokinetics; D011374:Progesterone / Q000008:administration & dosage* / Q000032:analysis / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011091:Polyesters; D011374:Progesterone; D004958:Estradiol; C062968:lactide-caprolactone copolymer