title: Malignant hyperthermia induced by general anesthesia for bone marrow harvesting.
abstract: We present a case of a bone marrow donor who developed rhabdomyolysis, acute renal failure and pulmonary edema following an apparently uneventful general anesthesia for bone marrow harvesting. Because malignant hyperthermia (MH) was suspected, he was treated with dantrolene, fluid loading, and continuous hemodiafiltration along with symptomatic supportive care. He made a full recovery and was discharged 3 weeks after harvest. Although the incidence of MH is low, marrow donation involves the risks of anesthesia as is seen in this case. Close monitoring is required to prevent life-threatening complications associated with the bone marrow harvesting procedure.
authors.affiliation: Third Department of Internal Medicine, University of Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Hosoya
authors.forename: K
authors.initials: K
authors.lastname: Miyagawa
authors.forename: T
authors.initials: T
authors.lastname: Mimura
authors.forename: S
authors.initials: S
authors.lastname: Hoshide
authors.forename: H
authors.initials: H
authors.lastname: Akazawa
authors.forename: Y
authors.initials: Y
authors.lastname: Kanda
authors.forename: N
authors.initials: N
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Hirai
authors.forename: K
authors.initials: K
authors.lastname: Maekawa
authors.forename: Y
authors.initials: Y
authors.lastname: Yazaki
mesh_terms: D000328:Adult; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D001853:Bone Marrow; D016026:Bone Marrow Transplantation; D004357:Drug Synergism; D006417:Hematuria / Q000139:chemically induced; D006801:Humans; D007530:Isoflurane / Q000009:adverse effects*; D008297:Male; D008305:Malignant Hyperthermia / Q000209:etiology*; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects*; D011654:Pulmonary Edema / Q000139:chemically induced; D012206:Rhabdomyolysis / Q000139:chemically induced; D013390:Succinylcholine / Q000009:adverse effects*; D014019:Tissue Donors
chemical_list: D018685:Anesthetics, Inhalation; D003473:Neuromuscular Nondepolarizing Agents; D007530:Isoflurane; D013390:Succinylcholine