title: Investigation of the influence of the Mm musculus MyoD1 allele on the efficiency of skeletal muscle regeneration.
abstract: MyoD1 alleles distinguish between the Mm musculus and Mm domesticus subspecies of Mus musculus. SJL/J mice, which belong to the Mm musculus subspecies, are able to regenerate skeletal muscle more efficiently than BALB/c mice which possess the Mm domesticus MyoD1 allele. Hence the possibility that regeneration responses are due to species-specific genetic differences including MyoD1 was investigated in this study. Quantitative morphometric analysis following muscle crush injury of 2 Mm musculus strains, MBK and MGL, has indicated that regeneration phenotype is not species-specific and may not be directly related to MyoD1 alleles. These results contrast with prior investigations conducted in SJL/J and BALB/c mice, and indicate that other genes may have a direct influence on skeletal muscle regeneration.
authors.affiliation: Department of Pathology, University of Western Australia, Nedlands, Australia.
authors.forename: S A
authors.initials: SA
authors.lastname: Marlow
authors.forename: P H
authors.initials: PH
authors.lastname: Kay
authors.forename: J K
authors.initials: JK
authors.lastname: McGeachie
authors.forename: J M
authors.initials: JM
authors.lastname: Papadimitriou
mesh_terms: D000483:Alleles; D000818:Animals; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018482:Muscle, Skeletal / Q000293:injuries / Q000473:pathology / Q000502:physiology*; D017570:MyoD Protein / Q000235:genetics* / Q000502:physiology; D010641:Phenotype; D012038:Regeneration / Q000502:physiology*; D013045:Species Specificity
chemical_list: D017570:MyoD Protein