Peptic activity and gastroduodenal mucosal damage.
This contribution reviews briefly the history of the discovery and characterization of peptic activity; secretory models and current concepts regarding the regulation of pepsinogen secretion; and evidence that pepsin is a necessary co-factor for gastroduodenal mucosal injury. Several animal studies indicate that peptic activity is required for acid- and nonsteroidal anti-inflammatory drug-induced gastroduodenal ulceration. A more vigorous approach to the development of anti-peptic drugs for the treatment of peptic ulcer disease is encouraged.
Raufman
J P
JP
Division of Gastroenterology, University of Arkansas for Medical Sciences, Little Rock 72205-7199, USA.
D000818:Animals; D004386:Duodenum / Q000187:drug effects* / Q000473:pathology*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology*; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology*; D010434:Pepsin A / Q000009:adverse effects*
D010434:Pepsin A