Distribution of platinum in human gynecologic tissues and lymph nodes after intravenous and intraarterial neoadjuvant chemotherapy.
Fourteen patients with ovarian and cervical cancer were treated with platinum drug-based intravenous and intraarterial neoadjuvant chemotherapy, respectively, followed by reductive surgery. Platinum accumulation in tissues was assayed to compare the distribution of platinum in cancer tissues, myometrium, ovary, and pelvic lymph node following intravenous and intraarterial administration. Platinum accumulation was higher in the cancer tissue and in the myometrium than in the ovary and the lymph nodes after the intraarterial neoadjuvant chemotherapy. The level of platinum accumulation in tissues to that in the cancer tissues was calculated and compared between the two groups. The level of platinum accumulation in the lymph node to that in the cancer tissue was significantly higher in the intravenous than in the intraarterial group. Furthermore, the relative platinum accumulation was calculated from the total dosage of cisplatin administered. The relative platinum accumulation in the cancer tissue and the myometrium was significantly higher in the intraarterial than in the intravenous group. However, there were no significant differences in the lymph nodes. These findings suggest that intraarterial neoadjuvant chemotherapy should be effective on advanced cervical cancer.
Ishikawa
H
H
Department of Gynecology, Aichi Cancer Center, Nagoya, Japan.
Kikkawa
F
F
Tamakoshi
K
K
Matsuzawa
K
K
Kawai
M
M
Suganuma
N
N
Tomoda
Y
Y
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D016190:Carboplatin / Q000493:pharmacokinetics / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008875:Middle Aged; D009215:Myometrium / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D010984:Platinum / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000378:metabolism*
D000970:Antineoplastic Agents; D010984:Platinum; D016190:Carboplatin; D002945:Cisplatin