title: High-signal lesions in the midbrain on T1-weighted MRI in an HIV-infected patient.
abstract: In addition to opportunistic infections, neoplasms or cerebrovascular complications, metabolic encephalopathies are a classical cause of diffuse brain dysfunction in HIV infection and are frequent in the terminal stage. We report an HIV-infected patient with symmetrical, focally increased signal in the midbrain on proton density-and T1-weighted MRI without corresponding high signal on T2-weighted images or on CT. While the precise nature and cause of this uncommon finding is not fully understood, the available evidence suggests that these lesions might represent a novel metabolic encephalopathy.
authors.affiliation: Department of Neurology, University of Münster, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Lüttmann
authors.forename: I W
authors.initials: IW
authors.lastname: Husstedt
authors.forename: G
authors.initials: G
authors.lastname: Schuierer
authors.forename: G
authors.initials: G
authors.lastname: Kuhlenbaümer
authors.forename: S
authors.initials: S
authors.lastname: Stodieck
authors.forename: M
authors.initials: M
authors.lastname: Riedasch
authors.forename: D
authors.initials: D
authors.lastname: Reichelt
authors.forename: W
authors.initials: W
authors.lastname: Zidek
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis*; D000328:Adult; D001928:Brain Diseases, Metabolic / Q000175:diagnosis; D003937:Diagnosis, Differential; D006679:HIV Seropositivity / Q000175:diagnosis; D015497:HIV-1; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008636:Mesencephalon / Q000473:pathology*; D011712:Pyramidal Tracts / Q000473:pathology; D013378:Substantia Nigra / Q000473:pathology; D014057:Tomography, X-Ray Computed