Cell proliferation, cell loss and expression of bcl-2 and p53 in human pulmonary neoplasms.
Immunohistochemical staining of bcl-2 and p53 proteins was compared with thymidine labelling index (TLI) and cell loss factor (O) in lung cancer. Neither bcl-2 nor p53 overexpression was associated with high cell loss but strong bcl-2 staining was associated with higher TLI. Concomitant strong p53 and bcl-2 expression, not the usual inverse relationship, plus high cell-loss factor was present in three neuroendocrine carcinomas. Other factors presumably have a role in controlling cell death in these tumours.
Kennedy
M M
MM
Department of Pathology, Aberdeen University Medical School, Foresterhill, UK.
Lamb
D
D
King
G
G
Kerr
K M
KM
D017209:Apoptosis; D002283:Carcinoma, Bronchogenic / Q000378:metabolism* / Q000473:pathology*; D002455:Cell Division; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology*; D009363:Neoplasm Proteins / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D009363:Neoplasm Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53