title: [Assessment of various new predictive parameters of the outcome of mechanical ventilation weaning].
abstract: OBJECTIVE
  To evaluate new indexes predicting weaning outcome from mechanical ventilation.
  
  
  METHODS
  Prospective study with two main end-points: a comparison of weaning indexes between successful and unsuccessful groups and an evaluation of their predicting value.
  
  
  METHODS
  Surgical-Medical Intensive Care Unit.
  
  
  METHODS
  Patients ventilated for more than 72 hours and subjected to a weaning trial until spontaneous ventilation.
  
  
  METHODS
  Traditional weaning parameters [respiratory rate (fsb), expiratory minute volume (Vesb), Maximal Inspiratory Pressure (MIP)] along with the new indexes [fsb/Vtsb) (rate to tidal volume ratio), CROP index (Compliance Rate Oxygenation Pressure), P0.1/MIP, IEQ (Inspiratory Effort Quotient), WI (Weaning Index)] were measured before discontinuation of ventilation support.
  
  
  RESULTS
  A statistically significant difference was observed between successful and unsuccessful groups for the following parameters: fsb, MIP, fsb/.Vtsb, CROP, Po.1/MIP and WI while no differences were observed for Vesb and IEQ. The sensitivity and specificity for the new indexes were respectively: fsb/Vtsb: 0.65 and 0.58; CROP: 0.70 and 0.63; P0.1/MIP: 0.85 and 0.36; WI: 0.69 and 0.47.
  
  
  CONCLUSIONS
  A statistically significant difference between successful and unsuccessful groups was observed for some but not all new indexes; the diagnostic accuracy of the new indexes were no better than additional parameters.
authors.affiliation: Ospedale Maggiore Servizio di Anestesia e Rianimazione, Azienda Ospedale, Parma.
authors.forename: M
authors.initials: M
authors.lastname: Mergoni
authors.forename: A
authors.initials: A
authors.lastname: Costa
authors.forename: S
authors.initials: S
authors.lastname: Primavera
authors.forename: A
authors.initials: A
authors.lastname: Salvadori
authors.forename: A
authors.initials: A
authors.lastname: Saccani
authors.forename: P
authors.initials: P
authors.lastname: Zuccoli
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015300:Ventilator Weaning
vernacular_title: Valutazione di alcuni nuovi parametri predittivi dell'esito dello svezzamento dalla ventilazione meccanica.