title: [Methods of diagnosis of thallium intoxication and its antidote therapy].
abstract: Absence of early signs specific for thallium intoxication requires objective diagnostic methods. The studies covered 4 techniques: electroretinography (ERG), assessment of urine levels of thallium and delta-aminolevulinic acid, capillaroscopy. The authors supported their previous foundation concerning diagnostic value of ERG for early diagnosis of thallium effects (higher amplitude of b-wave in one and that of a-wave in 8 out of 10 examinees). Further experimental and clinical basis for grading the intoxication through amounts of urinary thallium were found promising. Capillaroscopy method appeared informative: 8 out of 12 examinees demonstrated spastic and atonic state of hand capillaries--that provided objective verification of vascular disorders in workers exposed to thallium and its derivatives.
authors.forename: L P
authors.initials: LP
authors.lastname: Shabalina
authors.forename: V F
authors.initials: VF
authors.lastname: Krillov
authors.forename: V S
authors.initials: VS
authors.lastname: Spiridonova
authors.forename: M M
authors.initials: MM
authors.lastname: Poliakova
authors.forename: O L
authors.initials: OL
authors.lastname: Popova
authors.forename: A M
authors.initials: AM
authors.lastname: Shamshinova
mesh_terms: D000622:Aminolevulinic Acid / Q000652:urine; D000931:Antidotes; D002196:Capillaries; D004596:Electroretinography; D006225:Hand / Q000098:blood supply; D006801:Humans; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis* / Q000188:drug therapy; D011041:Poisoning / Q000175:diagnosis / Q000188:drug therapy; D013793:Thallium / Q000506:poisoning* / Q000652:urine
chemical_list: D000931:Antidotes; D000622:Aminolevulinic Acid; D013793:Thallium
vernacular_title: Metody diagnostiki tallievykh intoksikatsiĭ i antidotnaia terapiia tallotoksikozov.