An investigation of polymorphism in the interleukin-10 gene promoter.
Interleukin-10 (IL-10) has been described as an anti-inflammatory cytokine and B-cell proliferation factor and has been implicated in autoimmunity, tumorigenesis and transplantation tolerance. We have identified three single base pair substitutions in the IL-10 gene promoter and have investigated whether this polymorphism correlates with IL-10 protein production in vitro.
Turner
D M
DM
Tissue Typing Laboratory, St Mary's Hospital, Manchester, UK.
Williams
D M
DM
Sankaran
D
D
Lazarus
M
M
Sinnott
P J
PJ
Hutchinson
I V
IV
D002478:Cells, Cultured; D016207:Cytokines / Q000235:genetics; D005786:Gene Expression Regulation / Q000276:immunology; D005787:Gene Frequency / Q000276:immunology; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis / Q000235:genetics*; D008214:Lymphocytes; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic / Q000276:immunology*; D011401:Promoter Regions, Genetic / Q000276:immunology*; D017422:Sequence Analysis, DNA
D016207:Cytokines; D016753:Interleukin-10