title: [Gastric mucosa changes caused by anti-inflammatory agents in childhood].
abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) and steroids are very commonly prescribed. Morbidity and mortality from nonsteroidal anti-inflammatory drugs (NSAID) and steroids continue to be a significant health problem. In this paper are reported: 1) the biological insights into injurious effects of NSAIDs and steroids on mucosal protection and repair; 2) our clinical experience in the diagnosis and the management of children affected by secondary ulcer disease induced by therapeutic doses of NSAIDs and steroids; 3) the guidelines in the prevention of the NSAIDs and steroids-induced gastric damage.
authors.affiliation: Divisione di Pediatria, Azienda Ospedaliera Santobono di Napoli, Italia.
authors.forename: M
authors.initials: M
authors.lastname: Berni Canani
authors.forename: B
authors.initials: B
authors.lastname: Cirillo
authors.forename: G M
authors.initials: GM
authors.lastname: Della Rotonda
authors.forename: R
authors.initials: R
authors.lastname: Berni Canani
mesh_terms: D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004415:Dyspepsia / Q000139:chemically induced; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D007223:Infant; D008297:Male; D013256:Steroids / Q000009:adverse effects*; D013276:Stomach Ulcer / Q000139:chemically induced
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013256:Steroids
vernacular_title: Alterazioni mucosali gastriche da assunzione di farmaci antinfiammatori in età pediatrica.