title: Pulmonary hemosiderosis with hypersensitivity to buckwheat.
abstract: BACKGROUND
  Adverse reactions after ingesting buckwheat are known to be IgE-mediated. Further, hypersensitivity reactions may be involved in some patients with pulmonary hemosiderosis related to cow milk sensitivity. We, however, encountered a patient with pulmonary hemosiderosis related to buckwheat protein without high levels of buckwheat-specific IgE antibodies.
  
  
  OBJECTIVE
  The aim of this study was to investigate the mechanisms.
  
  
  METHODS
  RAST for anti-buckwheat IgE, skin prick test, skin patch test, and proliferative responses of peripheral blood mononuclear cells to buckwheat were investigated in this patient.
  
  
  RESULTS
  RAST values for buckwheat protein were negative, and skin prick test for buckwheat protein also gave negative results. On the other hand, skin patch testing for buckwheat protein elicited positive responses. Further, peripheral blood mononuclear cells of our patient responded to buckwheat protein.
  
  
  CONCLUSIONS
  Our patient had pulmonary hemosiderosis related to non-immediate buckwheat protein hypersensitivity.
authors.affiliation: Department of Pediatrics, Gifu University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Agata
authors.forename: N
authors.initials: N
authors.lastname: Kondo
authors.forename: O
authors.initials: O
authors.lastname: Fukutomi
authors.forename: M
authors.initials: M
authors.lastname: Takemura
authors.forename: H
authors.initials: H
authors.lastname: Tashita
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: S
authors.initials: S
authors.lastname: Shinoda
authors.forename: T
authors.initials: T
authors.lastname: Nishida
authors.forename: M
authors.initials: M
authors.lastname: Shinbara
authors.forename: T
authors.initials: T
authors.lastname: Orii
mesh_terms: D002478:Cells, Cultured; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005512:Food Hypersensitivity / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D006486:Hemosiderosis / Q000097:blood / Q000150:complications*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis*; D007073:Immunoglobulin E / Q000032:analysis / Q000276:immunology; D007074:Immunoglobulin G / Q000032:analysis; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000378:metabolism; D008168:Lung / Q000000981:diagnostic imaging; D008171:Lung Diseases / Q000097:blood / Q000150:complications*; D010328:Patch Tests; D010940:Plant Proteins / Q000276:immunology*; D011852:Radioallergosorbent Test; D011859:Radiography; D012882:Skin Tests; D014908:Triticum / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G; D010940:Plant Proteins; D007073:Immunoglobulin E