Experimental evidence for toxic damage induced by a dimeric anthracenone: diast T-514 (peroxisomicine A2).
Dimeric anthracenones obtained from the genus Karwinskia (Rhamnaceae) are characteristic compounds isolated from the plants of this species. Previous toxicity studies demonstrated Diast T-514 to be toxic to animals in experimental settings. Diast T-514 extracted and characterized from Karwinskia parvifolia, was studied in CD1 mice. The LD50 for this compound was determined. Animals were tested with Diast T-514 following enteral and parenteral administration. An LD50 dose by both oral and intraperitoneal administration showed selective damage to target organs.
Martínez
F J
FJ
Departamento de Farmacologia y Toxicologia, Nuevo Leon, Mexico.
Durón
R R
RR
de Torres
N W
NW
Piñeyro-Lopez
A
A
D000284:Administration, Oral; D000818:Animals; D000873:Anthracenes / Q000008:administration & dosage / Q000633:toxicity*; D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury; D019281:Dimerization; D005260:Female; D007274:Injections, Intraperitoneal; D008107:Liver Diseases / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D009928:Organ Specificity; D011108:Polymers / Q000008:administration & dosage / Q000633:toxicity; D011654:Pulmonary Edema / Q000139:chemically induced / Q000473:pathology
D000873:Anthracenes; D000972:Antineoplastic Agents, Phytogenic; D011108:Polymers; C075149:Karwinskia toxin T-514