[The synchronization of cells in culture by macromolecular complexes of platinum].
Divalent platinum compounds: cis-dichlorodiammineplatinum (II) (DDP) and its new macromolecular complexes poly (hexacis[chloroammineaquaplatinum(II)])-micro- deoxyribonucleats (MCP) have been used for the first time as the cell culture synchronization inductors. It is established that when monolayer cell cultures are incubated in presence of the above compounds, the conditions are created under which cell cycle is blocked at the S-phase and more then 80% of cells are accumulated in the Gl-phase. MCP compound is preferable in this case.
Girin
V N
VN
Trokhimenko
E P
EP
Dziublik
I V
IV
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000187:drug effects; D004273:DNA, Neoplasm / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D046911:Macromolecular Substances; D017671:Platinum Compounds / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D004273:DNA, Neoplasm; D046911:Macromolecular Substances; D017671:Platinum Compounds; D004247:DNA
Sinkhronizatsiia kletok v kul'ture makromolekuliarnymi kompleksami platiny.