Vitamin C deficiency and risk of myocardial infarction: prospective population study of men from eastern Finland.
OBJECTIVE
To examine the association between plasma vitamin C concentrations and the risk of acute myocardial infarction.


METHODS
Prospective population study.


METHODS
Eastern Finland.


METHODS
1605 randomly selected men aged 42, 48, 54, or 60 who did not have either symptomatic coronary heart disease or ischaemia on exercise testing at entry to the Kuopio ischaemic heart disease risk factor study in between 1984 and 1989.


METHODS
Number of acute myocardial infarctions; fasting plasma vitamin C concentrations at baseline.


RESULTS
70 of the men had a fatal or non-fatal myocardial infarction between March 1984 and December 1992.91 men had vitamin C deficiency (plasma ascorbate < 11.4 mumol/l, or 2.0 mg/l), of whom 12 (13.2%) had a myocardial infarction; 1514 men were not deficient in vitamin C, of whom 58 (3.8%) had a myocardial infarction. In a Cox proportional hazards model adjusted for age, year of examination, and season of the year examined (August to October v rest of the year) men who had vitamin C deficiency had a relative risk of acute myocardial infarction of 3.5 (95% confidence interval 1.8 to 6.7, P = 0.0002) compared with those who were not deficient. In another model adjusted additionally for the strongest risk factors for myocardial infarction and for dietary intakes of tea fibre, carotene, and saturated fats men with a plasma ascorbate concentration < 11.4 mumol/l had a relative risk of 2.5 (1.3 to 5.2, P = 0.0095) compared with men with higher plasma vitamin C concentrations.


CONCLUSIONS
Vitamin C deficiency, as assessed by low plasma ascorbate concentration, is a risk factor for coronary heart disease.
Nyyssönen
K
K
Research Institute of Public Health, University of Kuopio, Finland.
Parviainen
M T
MT
Salonen
R
R
Tuomilehto
J
J
Salonen
J T
JT
D000328:Adult; D001206:Ascorbic Acid Deficiency / Q000150:complications* / Q000453:epidemiology; D001794:Blood Pressure / Q000502:physiology; D003327:Coronary Disease / Q000453:epidemiology; D004032:Diet; D005387:Finland / Q000453:epidemiology; D005527:Food, Fortified; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000209:etiology; D011446:Prospective Studies; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology