title: Iris juvenile xanthogranuloma studied by immunohistochemistry and flow cytometry.
abstract: An unusual large tan iris mass in a 19-month-old child was removed by iridocyclectomy and studied by light microscopy, immunohistochemistry, and flow cytometry. The excised mass consisted of granulomatous inflammation with numerous osteoclast-like giant cells and scattered atypical Touton giant cells. Immunohistochemistry studies showed that the cells were most consistent with mononuclear histiocytes. Flow cytometry showed that 90% of the cells sampled were T-lymphocytes, with a predominance of T-suppresser cytotoxic cells. Juvenile xanthogranuloma (XG) of the iris can occur as a large solitary mass, without signs of intraocular inflammation or hyphema.
authors.affiliation: Oncology Service, Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Shields
authors.forename: R C
authors.initials: RC
authors.lastname: Eagle
authors.forename: C L
authors.initials: CL
authors.lastname: Shields
authors.forename: M L
authors.initials: ML
authors.lastname: Collins
authors.forename: P
authors.initials: P
authors.lastname: DePotter
mesh_terms: D015415:Biomarkers / Q000032:analysis; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007498:Iris / Q000737:chemistry / Q000473:pathology; D007499:Iris Diseases / Q000473:pathology* / Q000601:surgery; D013601:T-Lymphocytes / Q000473:pathology; D014972:Xanthogranuloma, Juvenile / Q000473:pathology* / Q000601:surgery
chemical_list: D015415:Biomarkers