title: [Treatment of uncomplicated recurrent cystitis in women: lomefloxacin versus norfloxacin].
abstract: OBJECTIVE
  compare the acceptability of 3-day regimen with that of 10-day regimen of fluoroquinolones for the treatment of recurrent uncomplicated lower urinary tract infection in women.
  
  
  METHODS
  a multicentric, randomized open trial was conduced in 421 patients by gynecologic and general practitioners to determine acceptability, efficacy and safety of lomefloxacin 400 mg in a once a day dose given for three days compared with norfloxacin 800 mg in twice a day dose given for ten days for the treatment of recurrent uncomplicated lower urinary tract infection in women.
  
  
  RESULTS
  acceptability, assessed at day 14, was significantly better for lomefloxacin group than norfloxacin group, respectively 57,1 p.100 and 38,0 p.100. Clinical success rate at day 14 was 97,2 p.100 for lomefloxacin and 97,5 p.100 for norfloxacin; at day 30 clinical success rate was respectively 97,6 p.100 and 98,1 p.100 relapse at one year was comparable between two groups. Adverse events were reported respectively in 15,6 p.100 and 16,6 p.100 of the patients, vaginal infections, dermatologic disorders and digestive disorders (abdominal pain, nausea) predominated. There were no serious adverse event.
  
  
  CONCLUSIONS
  the acceptability is better for a 3-day regimen of lomefloxacin than a 10-day regimen of norfloxacin for treatment of recurrent uncomplicated lower urinary tract infection in women for comparable efficacy and safety.
authors.affiliation: Hôpital Saint-Joseph, Paris.
authors.forename: J
authors.initials: J
authors.lastname: Guibert
authors.forename: H
authors.initials: H
authors.lastname: Herman
authors.forename: M H
authors.initials: MH
authors.lastname: Capron
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D003556:Cystitis / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D008875:Middle Aged; D009643:Norfloxacin / Q000627:therapeutic use*; D010342:Patient Acceptance of Health Care; D015363:Quinolones / Q000627:therapeutic use*; D012008:Recurrence; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C053091:lomefloxacin; D009643:Norfloxacin
vernacular_title: Traitement de la cystite non compliquée récidivante de la femme: loméfloxacine versus norfloxacine.