title: Patterns of oncogene activation in human neuroblastoma cells.
abstract: Human neuroblastoma is the most frequent solid tumor in children. Recent studies suggest that a multiplicity of genomic alterations contributes to neuroblastoma, the most frequent and well studied being deletion of the short arm of chromosome 1 and amplification of N-MYC. We here present and discuss different patterns of oncogene activation including, amplification of N-MYC, duplication of N-MYC and amplification of MDM2.
authors.affiliation: Deursches Krebsforschungszentrum, Abteilung Zytogenetik, Heidelberg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Corvi
authors.forename: L
authors.initials: L
authors.lastname: Savelyeva
authors.forename: M
authors.initials: M
authors.lastname: Schwab
mesh_terms: D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D016259:Genes, myc / Q000235:genetics; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics; D009447:Neuroblastoma; D009687:Nuclear Proteins; D009857:Oncogenes / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics; D051736:Proto-Oncogene Proteins c-mdm2
chemical_list: D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2