Chronobiologic aspects of ischemic coronary artery disease.
Convincing evidence is now available suggesting that several unfavorable cardiovascular events respect a well-defined diurnal pattern in their occurrence. In particular, ischemic heart disease has been widely investigated, and many data indicate a constellation of underlying risk factors whose temporal coincidence might act as triggering factors in the occurrence of acute events. In this paper, the recent knowledge concerning both epidemiology of ischemic heart disease and potentially favoring factors are reviewed from a chronobiological point of view.
Manfredini
R
R
First Institute of Internal Medicine, University of Ferrara, Italy.
Gallerani
M
M
Portaluppi
F
F
Salmi
R
R
Chierici
F
F
Tassi
A
A
Rizzioli
E
E
Notarstefano
P
P
Risichella
I S
IS
Mirizio
A M
AM
Fersini
C
C
D000787:Angina Pectoris / Q000453:epidemiology; D002940:Circadian Rhythm; D003327:Coronary Disease / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D016757:Death, Sudden, Cardiac / Q000453:epidemiology; D004562:Electrocardiography; D006339:Heart Rate; D006801:Humans; D009203:Myocardial Infarction / Q000453:epidemiology; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption; D017395:Plasminogen Activator Inhibitor 1 / Q000502:physiology; D012307:Risk Factors; D010959:Tissue Plasminogen Activator / Q000502:physiology
D017395:Plasminogen Activator Inhibitor 1; D010959:Tissue Plasminogen Activator