title: Monocular optokinetic nystagmus in humans with age-related maculopathy.
abstract: OBJECTIVE
  To investigate full field monocular optokinetic nystagmus (OKN) in patients with age-related maculopathy (ARM) and relative central scotoma.
  
  
  METHODS
  Six patients aged 59-88 years with bilateral ARM and an aged-matched control group of six patients aged 54-83 years were examined. Visual fields were assessed with a Humphrey field analyser using the threshold 30-1 routine. Monocular full field horizontal optokinetic stimuli were presented on a hemicylindrical screen subtending 172 degrees horizontally and 50 degrees vertically. The stimulus was a projected random dot pattern and three stimulus velocities were used, 30, 50, and 70 degrees/s in both nasalward and temporalward directions. Each trial lasted between 30 and 40 seconds and eye movements were monitored using infrared oculography.
  
  
  RESULTS
  The ARM patients had relative central scotomas with an average depth of 10 dB. Neither the ARM nor the age-matched groups displayed any directional preponderance or a buildup of the slow phase eye velocity with time. No statistically significant difference in the gain was found between the two groups (p > 0.05).
  
  
  CONCLUSIONS
  Marked central field loss in ARM does not significantly impair OKN gain. This supports the view that complete central retinal integrity is by no means essential and that the peripheral retina provides an important input to the generation of OKN.
authors.affiliation: Department of Optometry and Vision Sciences, UMIST, Manchester.
authors.forename: R V
authors.initials: RV
authors.lastname: Abadi
authors.forename: M
authors.initials: M
authors.lastname: Pantazidou
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D017120:Nystagmus, Optokinetic / Q000502:physiology*; D012607:Scotoma / Q000503:physiopathology; D014792:Visual Acuity; D014794:Visual Fields