title: Polymorphisms of the TAP2 gene may influence antibody response to live measles vaccine virus.
abstract: The transporter associated with antigen processing (TAP) gene products transport peptides from the cytosol to the endoplasmic reticulum for processing by the immune system. We hypothesized that polymorphisms within the TAP genes may influence measles vaccine antigen processing and hence antibody response. TAP genotypes were determined for subjects who were measles vaccine nonresponders (n = 32) and hyper-responders (n = 28). TAP1 and TAP2 alleles were determined by PCR amplification of specific alleles (PASA). Measles vaccine nonresponders were more likely to be homozygous at TAP2 position 665 than were hyper-responders (OR = 5.0, P = 0.016). Lastly, a trend was found in the overall distribution of all TAP2 genotype frequencies between hyper-responders and nonresponders (P = 0.08). No association was found between TAP1 polymorphisms and vaccine response. These data reveal an association between TAP2 genotype and measles vaccine antibody response which may explain one mechanism behind vaccine failure.
authors.affiliation: Mayo Vaccine Research Group, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Hayney
authors.forename: G A
authors.initials: GA
authors.lastname: Poland
authors.forename: P
authors.initials: P
authors.lastname: Dimanlig
authors.forename: D J
authors.initials: DJ
authors.lastname: Schaid
authors.forename: R M
authors.initials: RM
authors.lastname: Jacobson
authors.forename: J J
authors.initials: JJ
authors.lastname: Lipsky
mesh_terms: D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000917:Antibody Formation / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005787:Gene Frequency; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008458:Measles Vaccine / Q000276:immunology*; D011110:Polymorphism, Genetic
chemical_list: D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D000914:Antibodies, Viral; D008458:Measles Vaccine; C071692:TAP2 protein, human