title: A multicenter clinical trial of a biosynthetic skin replacement, Dermagraft-TC, compared with cryopreserved human cadaver skin for temporary coverage of excised burn wounds.
abstract: This multicenter study compared the use of a biosynthetic human skin substitute with frozen human cadaver allograft for the temporary closure of excised burn wounds. Dermagraft-TC (Advanced Tissue Sciences, Inc.) (DG-TC) consists of a synthetic material onto which human neonatal fibroblasts are cultured. Burn wounds in 66 patients with a mean age of 36 years and a mean burn size of 44% total body surface area (28% total body surface area full-thickness) were surgically excised. Two comparable sites, each approximately 1% total body surface area in size, were randomized to receive either DG-TC or allograft. Both sites were then treated in the same manner. When clinically indicated (> 5 days after application) both skin replacements were removed, and the wound beds were evaluated and prepared for grafting. DG-TC was equivalent or superior to allograft with regard to autograft take at postautograft day 14. DG-TC was also easier to remove, had no epidermal slough, and resulted in less bleeding than did allograft while maintaining an adequate wound bed. Overall satisfaction was better with DG-TC.
authors.affiliation: Department of Surgery, University of Texas, Southwestern Medical Center, Dallas 75235-9031, USA.
authors.forename: G F
authors.initials: GF
authors.lastname: Purdue
authors.forename: J L
authors.initials: JL
authors.lastname: Hunt
authors.forename: J M
authors.initials: JM
authors.lastname: Still
authors.forename: E J
authors.initials: EJ
authors.lastname: Law
authors.forename: D N
authors.initials: DN
authors.lastname: Herndon
authors.forename: I W
authors.initials: IW
authors.lastname: Goldfarb
authors.forename: W R
authors.initials: WR
authors.lastname: Schiller
authors.forename: J F
authors.initials: JF
authors.lastname: Hansbrough
authors.forename: W L
authors.initials: WL
authors.lastname: Hickerson
authors.forename: H N
authors.initials: HN
authors.lastname: Himel
authors.forename: G P
authors.initials: GP
authors.lastname: Kealey
authors.forename: J
authors.initials: J
authors.lastname: Twomey
authors.forename: A E
authors.initials: AE
authors.lastname: Missavage
authors.forename: L D
authors.initials: LD
authors.lastname: Solem
authors.forename: M
authors.initials: M
authors.lastname: Davis
authors.forename: M
authors.initials: M
authors.lastname: Totoritis
authors.forename: G D
authors.initials: GD
authors.lastname: Gentzkow
mesh_terms: D000328:Adult; D002056:Burns / Q000601:surgery*; D002102:Cadaver; D015925:Cryopreservation; D005260:Female; D006801:Humans; D008297:Male; D016038:Skin Transplantation; D017768:Skin, Artificial; D014184:Transplantation, Homologous; D014945:Wound Healing; D014946:Wound Infection