Homology with a repeated Yersinia pestis DNA sequence IS100 correlates with pesticin sensitivity in Yersinia pseudotuberculosis.
We have identified IS100 sequences in a specific subset of Yersinia pseudotuberculosis isolates that were also sensitive to the Y. pestis-produced bacteriocin, pesticin. In contrast, Y. pseudotuberculosis strains which did not contain IS100 sequences were not sensitive to pesticin. We propose that IS100 serves as a molecular marker that identifies a subset of Y. pseudotuberculosis isolates that have a particularly close evolutionary and/or ecological relationship with Y. pestis.
McDonough
K A
KA
David Axelrod Institute, Wadsworth Center, New York State Department of Health, Albany 12201-2002, USA. kathleen.mcdonough@wadsworth.org
Hare
J M
JM
D000818:Animals; D001430:Bacteriocins / Q000494:pharmacology*; D015342:DNA Probes; D004251:DNA Transposable Elements; D004269:DNA, Bacterial / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D008969:Molecular Sequence Data; D012150:Polymorphism, Restriction Fragment Length; D012091:Repetitive Sequences, Nucleic Acid; D012689:Sequence Homology, Nucleic Acid; D015010:Yersinia pestis / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D015011:Yersinia pseudotuberculosis / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity / Q000502:physiology
D001430:Bacteriocins; D015342:DNA Probes; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D005819:Genetic Markers; C011330:Pesticin