title: Response to chemotherapy of brain metastases from malignant pleural mesothelioma.
abstract: Brain metastases represent an uncommon complication in malignant pleural mesothelioma. A 55-year-old male suffering from malignant mesothelioma and pretreated with intracavitary chemotherapy and radiotherapy was submitted to systemic chemotherapy including lomustine, carboplatin, vinorelbine, fluorouracil and folates after diagnosis of bilateral cerebral deposits. The patient had an impressive response to chemotherapy, with complete regression of related symptoms. This case report represents the first on response to chemotherapy of brain metastases from mesothelioma. It points out that chemotherapy should be further explored in this subset of patients.
authors.affiliation: Division of Medical Oncology, City Hospital, Castelfranco Veneto, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Colleoni
authors.forename: G
authors.initials: G
authors.lastname: Liessi
authors.forename: C
authors.initials: C
authors.lastname: Avventi
authors.forename: F
authors.initials: F
authors.lastname: Pancheri
authors.forename: G
authors.initials: G
authors.lastname: Sgarbossa
authors.forename: G
authors.initials: G
authors.lastname: Vicario
authors.forename: P
authors.initials: P
authors.lastname: Manente
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary; D016190:Carboplatin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D005492:Folic Acid / Q000008:administration & dosage; D006801:Humans; D008130:Lomustine / Q000008:administration & dosage; D008297:Male; D008654:Mesothelioma / Q000188:drug therapy* / Q000556:secondary; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077235:Vinorelbine
chemical_list: D000964:Antimetabolites, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine; D008130:Lomustine; D005492:Folic Acid; D016190:Carboplatin; D000077235:Vinorelbine; D005472:Fluorouracil