Antiinvasive effects of Tiazofurin on liver-metastatic human colon carcinoma xenografts.
The effect of Tiazofurin (TR)-a C nucleoside with significant antineoplastic activity-have been studied on the liver metastasis formation of human colorectal carcinoma xenografts. TR treatment (especially at a dose of 300 mg/kg bwt) produced significant inhibition of metastasis formation in the liver and induced a significant and dose dependent decrease in the serum CEA level. There was not clear connection between the alteration of the weight of the primary tumor bearing spleen and the anti-metastatic activity of TR. In tumor cells derived from tumors obtained from TR treated animals a considerable decrease was observed in the expression of MMP2 metalloproteinase. Furthermore, TR induced a significant dose dependent inhibition of the microinvasiveness of colon carcinoma cells on EHS matrix. Based on the data presented here and published elsewhere, the authors suggest that in the remarkable liver metastasis inhibitory effects of TR modulation and the nonproliferative events of the multistep metastatic cascade plays an important role.
Lapis
K Y
KY
First Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Budapest, Hungary. klapis@korb1.sote.hu
Bocsi
J
J
Tóvári
J
J
Bartha
I
I
Timár
J
J
Rásó
E
E
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology* / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000473:pathology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008113:Liver Neoplasms / Q000517:prevention & control* / Q000556:secondary; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009361:Neoplasm Invasiveness; D012254:Ribavirin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D014183:Transplantation, Heterologous
D000964:Antimetabolites, Antineoplastic; D012254:Ribavirin; C033706:tiazofurin