title: Effect of endurance training and seasonal fluctuation on coagulation and fibrinolysis in young sedentary men.
abstract: The effect of 12 wk of submaximal training on hemostatic variables was studied in 20 young sedentary men (Tr) and 19 nontraining matched controls (Con). After training, a more pronounced increase in factor VIII coagulant activity (P < 0.01), reflected in a decrease in activated partial thromboplastin time (P < 0.01) during maximal exercise, was seen. Both basal plasminogen activator inhibitor 1 antigen (PAI-1 Ag) and activity (PAI-1 Act; P < 0.05), as well as basal and exercise-induced tissue-type plasminogen activator antigen (t-PA Ag; P < 0.05), were decreased after training. The overall effect on fibrinolysis was reflected in an increase in the t-PA Act/t-PA Ag ratio in the Tr group. In contrast, during the same period (February-June), the Con group demonstrated an increase in basal PAI-1 Ag and PAI-1 Act (P < 0.05), together with an increase in basal and exercise-induced t-PA Ag (P < 0.05). Both basal and exercise-induced t-PA Act were unchanged, but t-PA Act/t-PA Ag was decreased (P < 0.05) in the Con group. We conclude that physical training promotes both coagulation and fibrinolytic potential during exercise and may reverse unfavorable seasonal effects on fibrinolysis.
authors.affiliation: Department of Medical Physiology and Sports Medicine, University of Utrecht, The Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: van den Burg
authors.forename: J E
authors.initials: JE
authors.lastname: Hospers
authors.forename: M
authors.initials: M
authors.lastname: van Vliet
authors.forename: W L
authors.initials: WL
authors.lastname: Mosterd
authors.forename: B N
authors.initials: BN
authors.lastname: Bouma
authors.forename: I A
authors.initials: IA
authors.lastname: Huisveld
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D008297:Male; D012621:Seasons