Mechanism of gene expression by the glucocorticoid receptor: role of protein-protein interactions.
The glucocorticoid receptor belongs to an important class of transcription factors that alter the expression of target genes in response to a specific hormone signal. The glucocorticoid receptor can function at least at three levels: (1) recruitment of the general transcription machinery; (2) modulation of transcription factor action, independent of DNA binding, through direct protein-protein interactions; and (3) modulation of chromatin structure to allow the assembly of other gene regulatory proteins and/or the general transcription machinery on the DNA. This review will focus on the multifaceted nature of protein-protein interactions involving the glucocorticoid receptor and basal transcription factors, coactivators and other transcription factors, occurring at these different levels of regulation.
McEwan
I J
IJ
Department of Biosciences, Karolinska Institute, Huddinge, Sweden.
Wright
A P
AP
Gustafsson
J A
JA
D000595:Amino Acid Sequence; D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D008969:Molecular Sequence Data; D011485:Protein Binding; D011965:Receptors, Glucocorticoid / Q000502:physiology*; D015398:Signal Transduction
D011965:Receptors, Glucocorticoid