The effect of dexamethasone on phosphatidylcholine species composition in fetal rat lungs.
After dexamethasone treatment, a significant decrease in the monoenoic phosphatidylcholine 32 carbon species (palmitoyl-palmitoleylphosphatidylcholine and palmitoleyl-palmitoylphosphatidylcholine) and the phosphatidylcholine 34 carbon species (primarily palmitoyl-oleoylphosphatidylcholine) could be demonstrated both in absolute and relative terms, while the palmitic acid portion in the phosphatidylcholine fatty acids was nearly unchanged. This is in agreement with a significant reduction of the quantity of palmitoleic and oleic acids in the total phosphatidylcholine fatty acids.
Stettner
S
S
Department of Pathophysiology, Agricultural University, Lublin, Poland.
Ledwozyw
A
A
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D005229:Fatty Acids, Monounsaturated / Q000032:analysis / Q000378:metabolism; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology*; D008168:Lung / Q000737:chemistry* / Q000196:embryology*; D019301:Oleic Acid / Q000032:analysis / Q000378:metabolism; D010713:Phosphatidylcholines / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
D005229:Fatty Acids, Monounsaturated; D005938:Glucocorticoids; D010713:Phosphatidylcholines; C008757:palmitoleic acid; D019301:Oleic Acid; D003907:Dexamethasone