title: Diverse molecular interactions of the hnRNP K protein.
abstract: The hnRNP K protein is a versatile molecule that interacts with RNA, DNA, the proto-oncoprotein VaV, Src-like tyrosine and inducible serine/threonine kinases, the transcription factor TBP and a number of zinc-finger transcriptional repressors. The interaction of K protein with some of its protein partners is modulated by nucleic acids and K protein can alter the in vivo and in vitro rate of transcription. K protein can simultaneously engage several proteins and may facilitate molecular cross-talk. Taken together these diverse interactions suggest that K protein may act as a nucleic acid-regulated docking platform.
authors.affiliation: Department of Medicine, University of Washington, Seattle 98195, USA. karolb@u.washington.edu
authors.forename: K
authors.initials: K
authors.lastname: Bomsztyk
authors.forename: I
authors.initials: I
authors.lastname: Van Seuningen
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: O
authors.initials: O
authors.lastname: Denisenko
authors.forename: J
authors.initials: J
authors.lastname: Ostrowski
mesh_terms: D000595:Amino Acid Sequence; D004247:DNA / Q000378:metabolism; D015870:Gene Expression; D034641:Heterogeneous-Nuclear Ribonucleoprotein K; D034441:Heterogeneous-Nuclear Ribonucleoproteins; D006801:Humans; D012313:RNA / Q000378:metabolism; D012261:Ribonucleoproteins / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D034641:Heterogeneous-Nuclear Ribonucleoprotein K; D034441:Heterogeneous-Nuclear Ribonucleoproteins; D012261:Ribonucleoproteins; D012313:RNA; D004247:DNA