[The significance of lipid peroxidation in the pathogenesis of leptospirosis and its complications].
Lipid peroxidation (LPO) and antioxidant plasma activity were evaluated in 39 patients with leptospiral jaundice. At the height of the disease LPO proceeded more actively, being the highest in cases of severe complications. Early in the disease course general antioxidant activity of plasma was inhibited significantly more noticeably in complicated versus uncomplicated leptospirosis. This confirms pathogenetic implication of membrane LPO in leptospirosis. The approaches to prognostication of the disease course and completeness of the response are proposed.
Shuvalova
E P
EP
Antonova
T V
TV
Alekseeva
E A
EA
D058186:Acute Kidney Injury / Q000097:blood / Q000209:etiology; D000975:Antioxidants / Q000032:analysis; D006801:Humans; D007922:Leptospirosis / Q000097:blood* / Q000150:complications / Q000209:etiology; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000097:blood; D017114:Liver Failure, Acute / Q000097:blood / Q000209:etiology; D008315:Malondialdehyde / Q000097:blood; D011379:Prognosis; D012772:Shock, Septic / Q000097:blood / Q000209:etiology; D013997:Time Factors
D000975:Antioxidants; D008054:Lipid Peroxides; D008315:Malondialdehyde
Znachenie perekisnogo okisleniia lipidov v patogeneze leptospiroza i ego oslozhneniĭ.