title: Local intra-arterial fibrinolysis in thromboembolic "T" occlusions of the internal carotid artery.
abstract: Local intra-arterial fibrinolysis (LIF) is considered to support spontaneous recanalisation, which does not usually occur fast enough to prevent an infarct. Therefore, LIF may, at least theoretically, be especially useful in occlusions with large thromboembolic masses. We report our experience of LIF with urokinase in 12 patients with combined occlusions of the distal internal carotid, anterior and middle cerebral arteries (carotid "T" occlusions). There were 4 patients who survived with minor neurological deficits (Barthel index > 90), 4 with major deficits (Barthel index 40-55) and 4 patients died: in one of the last group a haematoma developed in a middle cerebral artery infarct. Recanalisation and clinical outcome were parallel in 10 of 12 patients. A patient with excellent leptomeningeal collaterals had a good clinical outcome despite only moderate recanalisation, and the patient with the parenchymal haematoma had good recanalisation. Recanalisation with urokinase in carotid "T" occlusions is often poor, but outcome can be good if treatment starts early, recanalisation succeeds and leptomeningeal collateral supply is good. Our results therefore encourage us, unlike previously reported series, to perform LIF in this type of occlusion.
authors.affiliation: Department of Neuroradiology, University of Würzburg, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Urbach
authors.forename: F
authors.initials: F
authors.lastname: Ries
authors.forename: B
authors.initials: B
authors.lastname: Ostertun
authors.forename: L
authors.initials: L
authors.lastname: Solymosi
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000098:blood supply; D002341:Carotid Artery Thrombosis / Q000000981:diagnostic imaging / Q000628:therapy*; D002533:Cerebral Angiography; D002544:Cerebral Infarction / Q000000981:diagnostic imaging / Q000628:therapy*; D003097:Collateral Circulation / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008578:Meninges / Q000098:blood supply; D008875:Middle Aged; D012039:Regional Blood Flow / Q000502:physiology; D015912:Thrombolytic Therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D014568:Urokinase-Type Plasminogen Activator