[Blood coagulation, genetics and post-angioplasty restenosis].
Throughout the last few decades, different factors have been related to coronary stenosis which is clinically evidenced by coronary heart disease, the leading cause of death in developed countries. Different experimental models have contributed towards defining some of these factors, and to an understanding of the physiopathology of the atherosclerotic lesion. The genetic basis related to individual responses to the same event is currently being established. As endothelial injury reparative mechanisms are fundamental in atherosclerosis pathogeny, patients who experiment restenosis after undergoing revascularization procedures are useful human models in the study of these processes. We review from the literature the genetic factors related to thrombus formation, which may be associated with restenosis after percutaneous transluminal coronary angioplasty, in order to define the most suitable anticoagulant therapy for each patient. We refer to the recently characterized gene for the platelet receptors and its relationship with fibrinogenous, factor Xa, PAI-I, and the involvement of apolipoprotein (a) in the coagulation process.
García-Ribes
M
M
Departamento de Ciencias Médicas y Quirúrgicas, Universidad de Cantabria. garciami@medi.unican.es
González-Lamuño
D
D
Colman
T
T
García-Fuentes
M
M
Revuelta
J M
JM
D015906:Angioplasty, Balloon, Coronary; D001777:Blood Coagulation; D004198:Disease Susceptibility; D015951:Factor Xa / Q000502:physiology; D005340:Fibrinogen / Q000502:physiology; D006801:Humans; D017270:Lipoprotein(a) / Q000502:physiology; D017202:Myocardial Ischemia / Q000097:blood / Q000235:genetics*; D017395:Plasminogen Activator Inhibitor 1 / Q000502:physiology; D010974:Platelet Aggregation; D012008:Recurrence
D017270:Lipoprotein(a); D017395:Plasminogen Activator Inhibitor 1; D005340:Fibrinogen; D015951:Factor Xa
Coagulación, genética y reestenosis postangioplastia.