title: Metabolic effects of i.v. propacetamol, metamizol or external cooling in critically ill febrile sedated patients.
abstract: We have measured the metabolic response to sequential administration of propacetamol, metamizol and/or external cooling in 20 febrile patients under sedation and analgesia and during mechanical ventilation. There was no change in temperature (T degree) after propacetamol therapy, whereas after metamizol only a small decrease was noted (from 38.9 (SEM 0.2) to 38.5 (0.3) degrees C; P = 0.02). External cooling produced a significant decrease in T degree (39.1 (0.2) to 37.1 (0.2) degrees C; P < 0.0001) accompanied by a decrease in energy expenditure (EE) (2034 (73) to 1791 (88) kcal day-1; P < 0.004). Heart rate and minute ventilation decreased significantly in parallel. There were no other changes in haemodynamics or pulmonary gas exchanges. We conclude that propacetamol and metamizol did not produce a clinically significant decrease in T degree in febrile ICU patients whereas external cooling decreased both T degree and EE. The parallel decrease in body temperature and EE seemed to be related to opioid administration or sedation, or both.
authors.affiliation: Department of Anaesthesiology, Pharmacology and Surgical Intensive Care, Geneva University Hospital, Switzerland.
authors.forename: B
authors.initials: B
authors.lastname: Poblete
authors.forename: J A
authors.initials: JA
authors.lastname: Romand
authors.forename: C
authors.initials: C
authors.lastname: Pichard
authors.forename: P
authors.initials: P
authors.lastname: König
authors.forename: P M
authors.initials: PM
authors.lastname: Suter
mesh_terms: D000082:Acetaminophen / Q000031:analogs & derivatives / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D016638:Critical Illness / Q000628:therapy*; D018592:Cross-Over Studies; D017679:Cryotherapy; D004177:Dipyrone / Q000627:therapeutic use; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D005334:Fever / Q000188:drug therapy / Q000628:therapy*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012121:Respiration, Artificial
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen; C063776:propacetamol; D004177:Dipyrone