title: Antenatal detection of Meckel-Grüber syndrome in only one dizygotic twin following in vitro fertilization and embryo transfer.
abstract: The first case of Meckel-Grüber syndrome in a dizygotic twin pregnancy following in vitro fertilization and embryo transfer is reported. An ultrasound examination at 26 weeks of gestation revealed multiple malformations of the presenting twin: the combination of an occipital encephalomeningocele, bilateral polycystic kidneys and postaxial polydactyly was suggestive of Meckel-Grüber syndrome. Diagnosis was confirmed after birth. The importance of this case is stressed since particular care must be taken to avoid multiple pregnancies in couples at risk undergoing assisted reproduction.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine Kanazawa University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Shozu
authors.forename: K
authors.initials: K
authors.lastname: Akimoto
authors.forename: J
authors.initials: J
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Sonoda
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: Y
authors.initials: Y
authors.lastname: Michikura
mesh_terms: D004200:Diseases in Twins; D004624:Embryo Transfer; D004677:Encephalocele / Q000000981:diagnostic imaging*; D005260:Female; D005307:Fertilization in Vitro; D005865:Gestational Age; D006801:Humans; D008588:Meningocele / Q000000981:diagnostic imaging*; D009778:Occipital Lobe; D007690:Polycystic Kidney Diseases / Q000000981:diagnostic imaging*; D017689:Polydactyly / Q000000981:diagnostic imaging; D011247:Pregnancy; D013577:Syndrome; D014429:Twins, Dizygotic; D016216:Ultrasonography, Prenatal