Isolation and chemical characterization of polysaccharides from Iwatake, Gyrophora esculenta Miyoshi.
A heteropolysaccharide and a beta-D-glucan were isolated from a lichen, Gyrophora esculenta Miyoshi (Iwatake), by cold water and alkali extractions, respectively. The chemical properties of purified polysaccharides were examined by acid hydrolysis, methylation, and GC-MS. The heteropolysaccharide is a highly branched galactomannan-type polysaccharide, containing an alpha-(1->6)-linked D-mannan backbone, and the glucan is a linear (1->6)-beta-D-glucan. With regard to the antitumor activity, both the galactomannan and (1->6)-beta-D-glucan had moderate inhibition activities on Sarcoma 180, but lower than those of branched (1->3)-beta-D-glucans.
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Department of Food and Nutrition, Faculty of Human Life Science, Osaka City University, Japan.
Isoda-Johmura
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Misaki
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D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D002240:Carbohydrate Sequence; D005591:Chemical Fractionation; D005690:Galactose / Q000031:analogs & derivatives; D005936:Glucans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008011:Lichens / Q000737:chemistry*; D008351:Mannans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D008969:Molecular Sequence Data; D009368:Neoplasm Transplantation; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012510:Sarcoma 180 / Q000188:drug therapy
D000970:Antineoplastic Agents; D005936:Glucans; D008351:Mannans; D011134:Polysaccharides; C012990:galactomannan; D005690:Galactose