title: Illudinic acid, a novel illudane sesquiterpene antibiotic.
abstract: A novel illudane sesquiterpene antibiotic (1) with activity against methicillin-resistant Staphylococcus aureus (MRSA), has been isolated. Its MIC against MRSA was found to be 16 micrograms/mL. It also shows L-1210 cytotoxicity with an IC50 of 10-15 micrograms/mL.
authors.affiliation: Merck Research Laboratories, Rahway, New Jersey 07065, USA. claude_dufresne@merck.com
authors.forename: C
authors.initials: C
authors.lastname: Dufresne
authors.forename: K
authors.initials: K
authors.lastname: Young
authors.forename: F
authors.initials: F
authors.lastname: Pelaez
authors.forename: A
authors.initials: A
authors.lastname: Gonzalez del Val
authors.forename: D
authors.initials: D
authors.lastname: Valentino
authors.forename: A
authors.initials: A
authors.lastname: Graham
authors.forename: G
authors.initials: G
authors.lastname: Platas
authors.forename: A
authors.initials: A
authors.lastname: Bernard
authors.forename: D
authors.initials: D
authors.lastname: Zink
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007939:Leukemia L1210 / Q000473:pathology; D051379:Mice; D008826:Microbial Sensitivity Tests; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D014407:Tumor Cells, Cultured
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D012717:Sesquiterpenes; C104806:illudinic acid