title: Dysregulation of bcl-2, c-myc, and Fas expression during tricyclic antidepressant-induced apoptosis in human peripheral lymphocytes.
abstract: Tricyclic antidepressants (TCAs) have been shown to induce apoptosis in human lymphocytes. In the present report, we investigated in parallel the regulation of the three oncogenes bcl-2, c-myc, and Fas. A reduction in c-myc and bcl-2 levels of 35-40% and 22-27%, respectively, was observed. On the other hand, Fas expression on the outer surface of the plasma membrane was increased up to 31%. In conclusion, bcl-2, c-myc, and Fas are undergoing dysregulation due to TCA-induced apoptosis.
authors.affiliation: Unit for Biochemical Toxicology, Wallenberg Laboratory, University of Stockholm, Sweden.
authors.forename: Z
authors.initials: Z
authors.lastname: Xia
authors.forename: J W
authors.initials: JW
authors.lastname: DePierre
authors.forename: L
authors.initials: L
authors.lastname: Nässberger
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000633:toxicity*; D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D015283:Citalopram / Q000633:toxicity; D002997:Clomipramine / Q000633:toxicity; D005786:Gene Expression Regulation / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D007099:Imipramine / Q000633:toxicity; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000378:metabolism; D019014:fas Receptor / Q000235:genetics / Q000378:metabolism
chemical_list: D000929:Antidepressive Agents, Tricyclic; D019253:Proto-Oncogene Proteins c-bcl-2; D016271:Proto-Oncogene Proteins c-myc; D019014:fas Receptor; D015283:Citalopram; D002997:Clomipramine; D007099:Imipramine