[Effect of five fluoroquinolones on the bactericidal activity of human polymorphonuclear leukocytes against Staphylococcus aureus].
It has been evaluated the effect of norfloxacin, ofloxacin, levofloxacin, fleroxacin and lomefloxacin of the respiratory burst of human polymorphonuclear leukocytes and their intracellular activity against Staphylococcus aureus. None of these agents significantly affected the superoxide and hydrogen peroxide radicals production by the polymorphonuclear leukocytes. All the quinolones except norfloxacin showed significant intracellular activity against S. aureus.
Ballesta
S
S
Departamento de Microbiología, Facultad de Medicina, Universidad de Sevilla.
Pascual
A
A
García
I
I
Conejo
C
C
Perea
E J
EJ
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001770:Blood Bactericidal Activity / Q000187:drug effects*; D024841:Fluoroquinolones; D006801:Humans; D016897:Respiratory Burst / Q000187:drug effects*; D015610:Serum Bactericidal Test; D013211:Staphylococcus aureus / Q000187:drug effects
D000890:Anti-Infective Agents; D024841:Fluoroquinolones
Efecto de cinco fluoroquinolonas en la actividad bactericida de los leucocitos polimorfonucleares humanos contra Staphylococcus aureus.