title: Thrombotic microangiopathy in a patient with chronic myelogenous leukemia on hydroxyurea.
abstract: We describe the case of a 57-year-old woman with chronic myelogenous leukemia who was on hydroxyurea and developed a fatal thrombotic microangiopathy with renal, retinal and central nervous system involvement. There was no evidence of medullary or extramedullary leukemia transformation. Repeated examinations of the peripheral blood film revealed only minimal morphological changes of microangiopathic hemolysis. The diagnosis was made by postmortem examination of the kidneys, brain, meninges and retina. The underlying etiology may have been a paraneoplastic phenomenon of the chronic phase of CML or may have indicated the beginning of transformation to an accelerated phase. A late side effect of hydroxyurea therapy cannot be excluded.
authors.affiliation: Department of Medicine, Central Hospital In Rogaland, Stavanger, Norway.
authors.forename: F
authors.initials: F
authors.lastname: Shammas
authors.forename: P
authors.initials: P
authors.lastname: Meyer
authors.forename: R
authors.initials: R
authors.lastname: Heikkila
authors.forename: T
authors.initials: T
authors.lastname: Apeland
authors.forename: L
authors.initials: L
authors.lastname: Gøransson
authors.forename: J
authors.initials: J
authors.lastname: Berland
authors.forename: K
authors.initials: K
authors.lastname: Kjellevold
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000188:drug therapy; D008875:Middle Aged; D011697:Purpura, Thrombotic Thrombocytopenic / Q000209:etiology* / Q000503:physiopathology
chemical_list: D000970:Antineoplastic Agents; D006918:Hydroxyurea