Cytotoxicity and electron microscopy of cell death induced by goniothalamin.
The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HGC-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells. Drug exposure studies indicated that the cytotoxic action of goniothalamin was time- and dose-dependent. At the ultrastructural level, goniothalamin-induced cytotoxicity revealed a necrotic mode of cell death towards MCF-7 cells.
Ali
A M
AM
Department of Biotechnology, Faculty of Food Science and Biotechnology, Universiti Pertanian Malaysia, Selangor, Malaysia.
Mackeen
M M
MM
Hamid
M
M
Aun
Q B
QB
Zauyah
Y
Y
Azimahtol
H L
HL
Kawazu
K
K
D016475:3T3 Cells; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects*; D006801:Humans; D051379:Mice; D008854:Microscopy, Electron; D011753:Pyrones / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D011753:Pyrones; C103280:goniothalamin