Ginseng total saponin inhibits the dopaminergic depletions induced by methamphetamine.
Pretreatment with ginseng total saponin (GTS) reduced the magnitude of the methamphetamine-induced dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillinic acid (HVA) depletions. It is suggested that GTS can, in part, prevent the methamphetamine-induced striatal dopaminergic depletions.
Oh
K W
KW
Department of Pharmacology, College of Pharmacy, Chungbuk National University, Cheongju, Korea.
Kim
H S
HS
Wagner
G C
GC
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003342:Corpus Striatum / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D018765:Dopamine Uptake Inhibitors / Q000037:antagonists & inhibitors*; D004563:Electrochemistry; D006719:Homovanillic Acid / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008297:Male; D008694:Methamphetamine / Q000037:antagonists & inhibitors*; D051379:Mice; D005894:Panax / Q000737:chemistry*; D010946:Plants, Medicinal; D012503:Saponins / Q000008:administration & dosage / Q000494:pharmacology*
D018765:Dopamine Uptake Inhibitors; D012503:Saponins; D015102:3,4-Dihydroxyphenylacetic Acid; D008694:Methamphetamine; D004298:Dopamine; D006719:Homovanillic Acid