title: Improved results after aggressive treatment of colonic involvement in necrotizing pancreatitis.
abstract: OBJECTIVE
  Colonic involvement is a rare but serious event in necrotizing pancreatitis. Early detection of this complication is difficult; a delay of diagnosis may lead to perforation and peritonitis. Two strategies of therapy have been developed in the past few years: an aggressive regimen of early resection and a conservative approach by ileostomy and observation.
  
  
  METHODS
  Fourteen of 118 patients treated for necrotizing pancreatitis from 1988 to 1995 presented with colonic necrosis. The diagnosis of necrosis was made if the color of the bowel wall demonstrated ischemia or hemorrhagic infarction or pulsations of the mesocolic vessels could not be palpated. The first two patients were treated by a conservative approach, the following 12 patients by immediate large bowel resection. Follow-up results of all surviving patients were obtained.
  
  
  RESULTS
  Patients with colonic lesions demonstrated an advanced septic state compared to patients who did not present this complication. Differences in the average Apache 2 scores on admission and the incidence of multiple organ failure were significant (Apache 2 score; 16.6 versus 11.9, p = 0.028, Wilcoxon; multiple organ failure; 71% versus 35%, p = 0.028, Fisher's exact test). Results after establishment of early discontinuity-resection of colonic necrosis compared favorably to those of a conservative strategy (mortality 4/12; 33% versus 2/2; 100%). The overall mortality was 43% (6 of 14 patients). Restorative surgery was performed in 6 patients without substantial morbidity and no mortality. Follow-up results were satisfactory in the majority of the patients.
  
  
  CONCLUSIONS
  Early resection of colonic lesions improves results in this dangerous complication of necrotizing pancreatitis.
authors.affiliation: First Department of Surgery, Rudolfstiftung Hospital, Vienna, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Kriwanek
authors.forename: C
authors.initials: C
authors.lastname: Armbruster
authors.forename: P
authors.initials: P
authors.lastname: Beckerhinn
authors.forename: K
authors.initials: K
authors.lastname: Dittrich
authors.forename: E
authors.initials: E
authors.lastname: Redl
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003082:Colectomy; D003106:Colon / Q000473:pathology; D003108:Colonic Diseases / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007081:Ileostomy; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D019283:Pancreatitis, Acute Necrotizing / Q000150:complications*; D016896:Treatment Outcome