title: Giant cell tumor of the larynx: case report and review of the literature.
abstract: BACKGROUND
  Primary manifestation of a giant cell tumor (GCT) in the larynx is exceedingly rare. Until now, only 17 cases have been reported in the literature. Characterization of a GCT can be difficult partly because of similarities with the giant cell subtype of malignant fibrous histiocytoma (MFH).
  
  
  METHODS
  The case of a 35-year-old man with a laryngeal GCT is presented. The patient underwent laryngectomy and has been free of recurrence since then (90 months). The literature is reviewed, and previously reported cases are presented in a table and compared with the presented case. The difficulties in the differential diagnosis are discussed.
  
  
  CONCLUSIONS
  When a laryngeal GCT is diagnosed, further differential diagnostic considerations should follow. One of these considerations is the MFH, which displays considerably more cellular atypia than GCT. Because most cases of giant cell MFH are high-grade sarcomas, the distinction between GCT and MFH is necessary.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Kiel, Germany.
authors.forename: J A
authors.initials: JA
authors.lastname: Werner
authors.forename: D
authors.initials: D
authors.lastname: Harms
authors.forename: A
authors.initials: A
authors.lastname: Beigel
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D005870:Giant Cell Tumors / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D007825:Laryngectomy; D008297:Male; D014057:Tomography, X-Ray Computed