[Autoimmune gastritis in its various stages].
Based on 196 consecutively diagnosed cases of autoimmune gastritis the histological spectrum of this disease was examined with special regard to the so called active autoimmune gastritis. The analysis revealed statistically significant differences. The chronic atrophic type showed more often microglandular hyperplasia of endocrine cells (p < 0.005) and revealed less often colonisation of the body mucosa by Helicobacter pylori (p < 0.001) than the active form. The inflammatory reaction of the antral mucosa, however, showed no differences. In addition immunohistochemical stainings were performed in 25 patients in whom parietal cell antibodies had been detected. In cases with active autoimmune gastritis T cells were found not only in the lamina propria but as well within the oxyntic glands as contrasted with the atrophic form. Only in the former group of patients furthermore B cells could be identified in the lamina propria. We conclude that especially with respect to the active form further knowledge of the progression of the autoimmune process might be gained.
Eidt
S
S
Institut für Pathologie, Universität Köln.
Oberhuber
G
G
Stolte
M
M
D000368:Aged; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D005756:Gastritis / Q000276:immunology* / Q000382:microbiology / Q000473:pathology*; D016481:Helicobacter Infections / Q000276:immunology / Q000473:pathology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D006965:Hyperplasia; D008297:Male
Die Autoimmungastritis in ihren verschiedenen Stadien.