title: Subcutaneous CAMPATH-1H in fludarabine-resistant/relapsed chronic lymphocytic and B-prolymphocytic leukaemia.
abstract: Seven patients with B-cell leukaemia - six with chronic lymphocytic leukaemia (CLL) and one with B-prolymphocytic leukaemia (B-PLL) - were treated with CAMPATH-1H*, a genetically reshaped CD52 monoclonal antibody, administered subcutaneously (s.c.) three times a week for 6-12 weeks. Four were resistant to, and three had had a short partial remission (PR) following, fludarabine chemotherapy. The patient with B-PLL achieved complete remission and three patients with CLL attained PR; two of the latter were retreated. The three remaining patients were non-responders. Three patients were transfusion-dependent before CAMPATH and all three became transfusion-independent after treatment. The overall median survival from starting CAMPATH-1H was 11 months. Three patients reactivated cytomegalovirus (CMV) during the course of treatment, and two were treated with, and responded to, ganciclovir.
authors.affiliation: Academic Department of Haematology and Cytogenetics, Royal Marsden NHS Trust, London.
authors.forename: A L
authors.initials: AL
authors.lastname: Bowen
authors.forename: A
authors.initials: A
authors.lastname: Zomas
authors.forename: E
authors.initials: E
authors.lastname: Emmett
authors.forename: E
authors.initials: E
authors.lastname: Matutes
authors.forename: M J
authors.initials: MJ
authors.lastname: Dyer
authors.forename: D
authors.initials: D
authors.lastname: Catovsky
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D000074323:Alemtuzumab; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D000912:Antibodies, Neoplasm / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D015448:Leukemia, B-Cell / Q000628:therapy*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000628:therapy*; D015463:Leukemia, Prolymphocytic / Q000628:therapy*; D008297:Male; D012008:Recurrence; D014740:Vidarabine / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000912:Antibodies, Neoplasm; D000970:Antineoplastic Agents; D000074323:Alemtuzumab; D014740:Vidarabine; C024352:fludarabine