title: Long-term observations of uterine contractions in nonpregnant dogs.
abstract: Uterine contractile activity in nonpregnant conscious dogs was investigated based on 2- to 6-mo-long continuous recording by means of a chronically implanted force transducer. We found that nonpregnant uterine contractile activity could be classified into six major patterns: sporadic contractions, weak and strong tonic contractions, weak and strong phasic contractions, and phasic contraction bursts. The contractile patterns during proestrus and estrus were the most active, with strong phasic and tonic contractions and phasic contraction bursts. The phasic and tonic contractions were inhibited dose-dependently by a beta 2 adrenergic agonist, ritodrine, and reproduced by an alpha 2 adrenergic agonist, clonidine. In contrast, the cholinergic inhibitors atropine and hexamethonium did not affect the spontaneous occurrence of these contractions, although bethanechol evoked uterine contractions. Oxytocin and prostaglandin F2 alpha-induced contractions were phasic during estrus, whereas they showed tonic increases with phasic contractions during proestrus, diestrus, and anestrus, and these contractions did not resemble the spontaneous contractions. In conclusion, the nonpregnant uterus contracts continuously in harmony with the estrous cycle phases, and its contractile activity is enhanced by alpha adrenergic receptors and inhibited by beta 2 adrenergic receptors.
authors.affiliation: Gastrointestinal Research Laboratory, Gunma University, Maebashi, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Ibuki
authors.forename: N
authors.initials: N
authors.lastname: Haga
authors.forename: S
authors.initials: S
authors.lastname: Muramatsu
authors.forename: A
authors.initials: A
authors.lastname: Mizumoto
authors.forename: Z
authors.initials: Z
authors.lastname: Itoh
mesh_terms: D000322:Adrenergic Agonists / Q000494:pharmacology; D000818:Animals; D018680:Cholinergic Antagonists / Q000494:pharmacology; D015237:Dinoprost / Q000494:pharmacology; D004285:Dogs; D004967:Estrogens / Q000097:blood; D004971:Estrus / Q000187:drug effects / Q000502:physiology; D005260:Female; D010121:Oxytocin / Q000494:pharmacology; D011374:Progesterone / Q000097:blood; D013270:Stomach / Q000502:physiology; D014160:Transducers, Pressure; D014590:Uterine Contraction / Q000502:physiology*; D014621:Vagina / Q000166:cytology / Q000502:physiology
chemical_list: D000322:Adrenergic Agonists; D018680:Cholinergic Antagonists; D004967:Estrogens; D011374:Progesterone; D010121:Oxytocin; D015237:Dinoprost