[Immunophenotype of nasal T-cell lymphoma].
The immunophenotype of 14 cases of nasal T/NK-cell lymphomas in Southern Japan were determined by double labelling with EBER-1 in situ hybridization and immunohistochemical staining. In all cases, EBER-1-positive tumor cells were positive for CD3 epsilon in their cytoplasms, but negative for CD4 and CD8. EBER-1-negative infiltrating cells were positive for CD3, CD4, and CD8 in 12 out of 14 cases. Therefore, the tumor cells in these nasal T/NK-cell lymphomas seem to be activated NK cells.
Eizuru
Y
Y
Div. Persistent and Oncogenic Viruses, Faculty of Medicine, Kagoshima University.
Ueno
K
K
D015703:Antigens, CD / Q000032:analysis; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D007694:Killer Cells, Natural / Q000276:immunology; D016399:Lymphoma, T-Cell / Q000821:virology*; D009669:Nose Neoplasms / Q000821:virology*; D010641:Phenotype
D015703:Antigens, CD