Comparative metabolism of tamoxifen and DNA adduct formation and in vitro studies on genotoxicity.
Tamoxifen has been demonstrated to be hepatocarcinogenic in some but not all strains of the laboratory rat and is not a carcinogen in the mouse. To resolve the question of whether tamoxifen is genotoxic in humans, many laboratories have studied its interspecies metabolism and its propensity to form DNA adducts. This review of the literature concludes that tamoxifen is not genotoxic in adult women based on comparative metabolism and the absence of measurable DNA adducts in women treated with tamoxifen. In addition, tamoxifen does not appear to be mutagenic in in vitro assays.
Tannenbaum
S R
SR
Division of Toxicology, Massachusetts Institute of Technology, Cambridge 02139-4307, USA.
D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000378:metabolism* / Q000494:pharmacology; D018736:DNA Adducts / Q000096:biosynthesis; D006801:Humans; D016296:Mutagenesis; D009152:Mutagenicity Tests; D009153:Mutagens; D013629:Tamoxifen / Q000378:metabolism* / Q000494:pharmacology
D018931:Antineoplastic Agents, Hormonal; D018736:DNA Adducts; D009153:Mutagens; D013629:Tamoxifen