Levels of stem cell factor and interleukin-3 in serum in acute Plasmodium falciparum malaria.
The purpose of the present study was to measure serum concentrations of stem cell factor (SCF) and interleukin-3 (IL-3) in patients with acute Plasmodium falciparum malaria. Serum samples from 15 patients were taken on day of admission and days 7, 14, 21, and 28. Anemia developed in 80% of patients. A transient increase in IL-3 could be observed at the beginning of the disease. It remains controversial whether the measured concentrations of IL-3 and SCF correlate with the grade of anemia. The possibly suppressed IL-3 and SCF production may contribute to the prolonged anemia in P. falciparum malaria, as has been shown for erythropoietin.
Burgmann
H
H
Department of Internal Medicine I, University of Vienna, Austria.
Looareesuwan
S
S
Wiesinger
E C
EC
Winter
W
W
Graninger
W
W
D000293:Adolescent; D000328:Adult; D000368:Aged; D000740:Anemia / Q000097:blood / Q000209:etiology*; D016022:Case-Control Studies; D004920:Erythropoiesis; D005260:Female; D006400:Hematocrit; D006801:Humans; D007377:Interleukin-3 / Q000097:blood*; D016778:Malaria, Falciparum / Q000097:blood* / Q000150:complications* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D019089:Stem Cell Factor / Q000097:blood*
D007377:Interleukin-3; D019089:Stem Cell Factor