title: Mixed-cryoglobulinemia associated with cutaneous vasculitis and pulmonary symptoms.
abstract: A 45-year-old Japanese man with Sjögren's syndrome developed recurrent skin ulcers, palpable purpura, and dyspnea. Serum mixed-type cryoglobulin level was elevated. A biopsy of his skin lesion showed the characteristic leukocytoclastic vasculitis of mixed-type cryoglobulinemia. Dyspnea, skin ulcers, and purpura resolved along with a reduction in the serum cryoglobulin level after prednisolone administration. This patient demonstrated cryoglobulinemia-associated vasculitis, as well as possible cryoglobulinemia-associated pulmonary symptoms.
authors.affiliation: Department of Internal Medicine, Keio University School of Medicine, Tokyo.
authors.forename: M
authors.initials: M
authors.lastname: Konishi
authors.forename: Y
authors.initials: Y
authors.lastname: Ohosone
authors.forename: M
authors.initials: M
authors.lastname: Matsumura
authors.forename: Y
authors.initials: Y
authors.lastname: Oyamada
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Kawahara
authors.forename: T
authors.initials: T
authors.lastname: Mimori
authors.forename: Y
authors.initials: Y
authors.lastname: Ikeda
mesh_terms: D003449:Cryoglobulinemia / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004417:Dyspnea / Q000209:etiology; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D000860:Hypoxia / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D011655:Pulmonary Embolism / Q000209:etiology; D011693:Purpura / Q000150:complications / Q000188:drug therapy; D012859:Sjogren's Syndrome / Q000150:complications / Q000188:drug therapy; D012871:Skin Diseases / Q000150:complications* / Q000188:drug therapy; D012883:Skin Ulcer / Q000150:complications / Q000188:drug therapy; D014657:Vasculitis / Q000150:complications* / Q000188:drug therapy
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone