The genomic structure of a mouse seminal vesicle autoantigen.
The genomic structure of an androgen-stimulated mouse seminal vesicle autoantigen was determined. Analysis of the nucleotide sequence established 2135 bp of the 5'-flanking region, four exons of 123, 136, 112, 227 bp, three introns of 1555, 1931, 316 bp, and 185 bp of the 3'-flanking region of this gene. Ten DNA segments, five in the 5'-flanking region, two in the first intron, and three in the second intron were identified to have more than 50% homology with the consensus sequence of the androgen response element (ARE). Two sets of adjacent DNA segments, one including -213 to -199 bp and -124 to -110 bp in the 5'-flanking region and the other including 2532 to 2546 bp and 2582 to 2596 bp in the second intron, are noticeable for their high degree of homology with ARE.
Yu
L C
LC
Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan.
Hsiao
Y L
YL
Yang
Y H
YH
Lin
M
M
Chen
Y H
YH
D000728:Androgens / Q000494:pharmacology; D000818:Animals; D001324:Autoantigens / Q000235:genetics*; D001483:Base Sequence; D016384:Consensus Sequence; D005091:Exons; D005796:Genes; D015698:Genomic Library; D007438:Introns; D051379:Mice; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D012045:Regulatory Sequences, Nucleic Acid; D029607:Seminal Vesicle Secretory Proteins; D014158:Transcription, Genetic
D000728:Androgens; D001324:Autoantigens; D029607:Seminal Vesicle Secretory Proteins; C085073:seminal vesicle autoantigen