Omeprazole-induced acute interstitial nephritis.
Omeprazole is a proton pump inhibitor widely used for the treatment of peptic ulcer disease. We report a patient presenting nonoliguric acute renal failure following omeprazole treatment. Both eosinophilia and eosinophiluria were observed, and the patient was diagnosed as having drug-induced acute interstitial nephritis. Renal failure spontaneously resolved when omeprazole was discontinued.
d'Adamo
G
G
Nephrology and Dialysis Unit, Ospedale Santa Spirito, Rome, Italy.
Spinelli
C
C
Forte
F
F
Gangeri
F
F
D000208:Acute Disease; D000368:Aged; D000897:Anti-Ulcer Agents / Q000009:adverse effects*; D001706:Biopsy; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004381:Duodenal Ulcer / Q000150:complications / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009395:Nephritis, Interstitial / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D009853:Omeprazole / Q000009:adverse effects*
D000897:Anti-Ulcer Agents; D003404:Creatinine; D009853:Omeprazole