title: The source of urinary nitrosamines in patients with enterocystoplasties.
abstract: OBJECTIVE
  To assess the factors influencing urinary nitrosamine production in patients with enterocystoplasties.
  
  
  METHODS
  The study comprised 100 patients with an enterocystoplasty, 20 patients with interstitial cystitis, 30 with infective cystitis and 120 control subjects drawn from hospital staff and out-patients. Urinary nitrosamine levels were measured and the urine samples cultured for microorganisms.
  
  
  RESULTS
  Nitrosamine levels were significantly higher only in patients with enterocystoplasties who also had higher urinary white cell counts or significant bacteriuria.
  
  
  CONCLUSIONS
  Patients with an enterocystoplasty and significant bacteriuria are most at risk from potential nitrosamine-induced epithelial injury.
authors.affiliation: Academic Department of Urology, Guy's Hospital, London, UK.
authors.forename: T A
authors.initials: TA
authors.lastname: Creagh
authors.forename: D
authors.initials: D
authors.lastname: Picramenos
authors.forename: E T
authors.initials: ET
authors.lastname: Smalley
authors.forename: C L
authors.initials: CL
authors.lastname: Walters
authors.forename: A R
authors.initials: AR
authors.lastname: Mundy
mesh_terms: D001437:Bacteriuria / Q000652:urine; D003556:Cystitis / Q000382:microbiology / Q000652:urine*; D018856:Cystitis, Interstitial / Q000652:urine; D006801:Humans; D007958:Leukocyte Count; D009602:Nitrosamines / Q000652:urine*; D014547:Urinary Diversion; D014552:Urinary Tract Infections / Q000652:urine*
chemical_list: D009602:Nitrosamines