Negative association of schizophrenia with HLA DQB1*0602: evidence from a second African-American cohort.
The authors attempted a replication of an earlier study of African-Americans, in which they detected a negative association of schizophrenia with HLA DQB1*0602. Patients with schizophrenia (n = 75, DSM-III-R criteria) and screened adult controls of African-American ethnicity (n = 66) were genotyped with respect to HLA DQB1*0602 using a combination of two polymerase chain reaction (PCR) based assays: amplification with sequence specific primers and a dot blot assay. A significant negative association with HLA DQB1 was not noted overall, but was present among women (female patients vs. female controls: odds ratio, OR = 0.42, 95% confidence intervals, CI = 0.32, 0.55). Reanalysis of the earlier study also revealed a gender related association. When the present and earlier samples from both genders were combined, the association persisted (OR 0.48; 95% CI: 0.12, 0.52). The present findings support and association between schizophrenia and the HLA DQB1 gene locus among African-Americans.
Nimgaonkar
V L
VL
Department of Psychiatry, University of Pittsburgh, School of Medicine, PA, USA. nimga@pitt.edu
Rudert
W A
WA
Zhang
X
X
Trucco
M
M
Ganguli
R
R
D000328:Adult; D044383:Black People / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D010414:Pennsylvania; D016133:Polymerase Chain Reaction; D011569:Psychiatric Status Rating Scales; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology; D012737:Sex Factors; D001741:Black or African American
D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen