title: Combination chemotherapy for malignant paraganglioma.
abstract: Treatment with a combination chemotherapeutic regimen consisting of cyclophosphamide, vincristine, and dacarbazine for malignant paraganglioma with hepatic metastasis is reported. A 51-year-old male presented with tumors in the retroperitoneal space and liver. The patient was diagnosed as having paraganglioma based on elevated levels of serum neuron-specific enolase, urinary catecholamine and vanillylmandelic acid, and on histological findings of the liver specimen. The patient was treated with this combination chemotherapy in repeated 21-day cycles. Temporary improvement in laboratory findings and a 20% reduction in the size of the hepatic masses were observed without severe adverse effects.
authors.affiliation: Department of Medicine, Nishiwaki Municipal Hospital.
authors.forename: S
authors.initials: S
authors.lastname: Kimura
authors.forename: M
authors.initials: M
authors.lastname: Iwai
authors.forename: T
authors.initials: T
authors.lastname: Fukuda
authors.forename: T
authors.initials: T
authors.lastname: Akamatsu
authors.forename: F
authors.initials: F
authors.lastname: Ochi
authors.forename: J
authors.initials: J
authors.lastname: Masugi
authors.forename: O
authors.initials: O
authors.lastname: Nakano
authors.forename: T
authors.initials: T
authors.lastname: Sakamoto
authors.forename: H
authors.initials: H
authors.lastname: Fukunaga
authors.forename: M
authors.initials: M
authors.lastname: Amano
authors.forename: T
authors.initials: T
authors.lastname: Fujimori
authors.forename: S
authors.initials: S
authors.lastname: Maeda
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002395:Catecholamines / Q000652:urine; D003520:Cyclophosphamide / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary; D008297:Male; D008875:Middle Aged; D010236:Paraganglioma, Extra-Adrenal / Q000175:diagnosis / Q000188:drug therapy* / Q000556:secondary; D010751:Phosphopyruvate Hydratase / Q000097:blood; D012186:Retroperitoneal Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D014642:Vanilmandelic Acid / Q000652:urine; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D002395:Catecholamines; D014642:Vanilmandelic Acid; D014750:Vincristine; D003606:Dacarbazine; D003520:Cyclophosphamide; D010751:Phosphopyruvate Hydratase