[Gastric mucosa changes caused by anti-inflammatory agents in childhood].
Nonsteroidal anti-inflammatory drugs (NSAIDs) and steroids are very commonly prescribed. Morbidity and mortality from nonsteroidal anti-inflammatory drugs (NSAID) and steroids continue to be a significant health problem. In this paper are reported: 1) the biological insights into injurious effects of NSAIDs and steroids on mucosal protection and repair; 2) our clinical experience in the diagnosis and the management of children affected by secondary ulcer disease induced by therapeutic doses of NSAIDs and steroids; 3) the guidelines in the prevention of the NSAIDs and steroids-induced gastric damage.
Berni Canani
M
M
Divisione di Pediatria, Azienda Ospedaliera Santobono di Napoli, Italia.
Cirillo
B
B
Della Rotonda
G M
GM
Berni Canani
R
R
D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004415:Dyspepsia / Q000139:chemically induced; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D007223:Infant; D008297:Male; D013256:Steroids / Q000009:adverse effects*; D013276:Stomach Ulcer / Q000139:chemically induced
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013256:Steroids
Alterazioni mucosali gastriche da assunzione di farmaci antinfiammatori in età pediatrica.