Cholinergic innervation of the lateralis medialis-suprageniculate nuclear complex (LM-Sg) of the cat's thalamus: a double labeling immunohistochemical study.
The purpose of this study was to investigate morphological characteristics of the synaptic relations of choline acetyltransferase (ChAT)-positive terminals that are made with a variety of post-synaptic profiles in the lateralis medialis-suprageniculate nuclear complex (LM-Sg) using ChAT, gamma-aminobutyric acid (GABA) and glutamate immunohistochemistry in combination with electron microscopical observations. The ChAT immunopositive profiles make asymmetrical synaptic contacts with glutamate immunopositive dendrites that are presumably derived from projection neurons, and/or GABA immunopositive interneurons. The present results indicate that ascending cholinergic mechanisms may be important for modifying information in both the extrinsic and intrinsic circuitries of LM-Sg.
Hoshino
K
K
Department of Neurobiology and Anatomy, Niigata University School of Medicine, Japan.
Hicks
T P
TP
Meguro
R
R
Hirano
S
S
Kase
M
M
Norita
M
M
D000818:Animals; D002415:Cats; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003712:Dendrites / Q000201:enzymology; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D009434:Neural Pathways / Q000166:cytology / Q000502:physiology; D009474:Neurons / Q000201:enzymology / Q000502:physiology* / Q000648:ultrastructure; D010275:Parasympathetic Nervous System / Q000166:cytology / Q000201:enzymology / Q000502:physiology*; D017729:Presynaptic Terminals / Q000201:enzymology; D013787:Thalamic Nuclei / Q000166:cytology / Q000201:enzymology / Q000502:physiology*
D002795:Choline O-Acetyltransferase