Improving the yield of 2-[18F]fluoro-2-deoxyglucose using a microwave cavity.
We have investigated the use of a microwave cavity (Labwell AB, Sweden) to improve the radiochemical yield of 2-[18F]fluoro-2-deoxyglucose (2-[18F]FDG). After characterizing the heating properties of the cavity, three steps of the Hamacher 2-[18F]FDG synthesis which require heating--azeotropic distillation of the target water, nucleophilic substitution, and hydrolysis of the product--were investigated separately. The average radiochemical yield of 2-[18F]FDG for the microwave synthesis, using the phase transfer reagent tetrabutylammonium bicarbonate, was 62 +/- 4% (72 +/- 5%, decay corrected, synthesis time = 31 min).
Taylor
M D
MD
Department of Medical Physics, University of Wisconsin-Madison 33706, USA.
Roberts
A D
AD
Nickles
R J
RJ
D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006358:Hot Temperature; D007202:Indicators and Reagents; D007700:Kinetics; D008872:Microwaves; D013997:Time Factors
D005462:Fluorine Radioisotopes; D007202:Indicators and Reagents; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose