title: Configuration of linear dynamic cardiomyoplasty for hypoplastic right ventricle.
abstract: BACKGROUND
  The purpose of this study is to determine feasibility of linear dynamic cardiomyoplasty with a briefly preconditioned latissimus dorsi in the experimental model simulating patch enlargement of the hypoplastic right ventricle.
  
  
  METHODS
  In 8 mongrel dogs, a diminished right ventricular chamber was reconstructed with an extended pericardial patch. A left latissimus dorsi, preconditioned for 2 weeks (2 Hz) after a previous 2-week vascular delay period, was placed on the patch, with the muscle fiber oriented in parallel to the right ventricular long axis.
  
  
  RESULTS
  Graft pacing with trained-pulses of 25 Hz at a 1:1 ratio showed significant augmentation of pulmonary flow and pressure (158% +/- 21%, 156% +/- 14%, respectively), contributing to restoring right ventricular function comparable with preoperative control, which was also confirmed by the right ventricular function curve and pressure-volume relationship analyzes. Continuous pacing was performed in 4 animals for 7 hours without evidence of muscle fatigue, implying feasibility of "working conditioning" after minimum preconditioning for this type of right heart assist.
  
  
  CONCLUSIONS
  Linear latissimus dorsi myoplasty can restore normal right ventricular performance at a physiologic preload, and may provide a surgical option for the hypoplastic right ventricle.
authors.affiliation: Department of Cardiovascular Surgery, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Morita
authors.forename: H
authors.initials: H
authors.lastname: Kurosawa
authors.forename: S
authors.initials: S
authors.lastname: Ishii
authors.forename: M
authors.initials: M
authors.lastname: Yoshitake
authors.forename: M
authors.initials: M
authors.lastname: Hanai
mesh_terms: D000818:Animals; D018421:Cardiomyoplasty / Q000379:methods*; D004285:Dogs; D004452:Echocardiography; D005240:Feasibility Studies; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D006352:Heart Ventricles / Q000002:abnormalities*; D016278:Ventricular Function, Right / Q000502:physiology