Effects of colectomy on gallbladder motility in patients with ulcerative colitis.
In order to gain insight into the possible mechanisms involved in gallstone formation in colectomized ulcerative colitis patients, we studied gallbladder motility by means of ultrasonography in three groups of subjects: controls (N = 40) and ulcerative colitis patients without (N = 30) and with (N = 20) colectomy. Impaired gallbladder emptying after a liquid fatty meal stimulus was observed in ulcerative colitis patients with colectomy compared with those obtained in ulcerative colitis patients without colectomy and controls (P = 0.001). The maximum percentage of gallbladder emptying also, was significantly lower (59.8%) than those seen in ulcerative colitis patients without colectomy (74.5%) and controls (77.8%) (P = 0.001). Diminished gallbladder emptying with ensuing stasis might be a contributory factor to the increased prevalence of gallstones in colectomized patients.
Damião
A O
AO
Department of Gastroenterology, University of São Paulo (USP) Medical School, Brazil.
Sipahi
A M
AM
Vezozzo
D P
DP
Gonçalves
A L
AL
Habr-Gama
A
A
Teixeira
M G
MG
Fukushima
J T
JT
Laudanna
A A
AA
D000328:Adult; D003082:Colectomy / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D016473:Gallbladder Emptying; D005746:Gastric Emptying; D006801:Humans; D008297:Male