Effect of age and caloric restriction on cutaneous wound closure in rats and monkeys.
Cutaneous wounds close more slowly in rats and monkeys as age increases. Caloric restriction of 40% in rats and 30% in monkeys did not significantly affect healing rates, although it did exert a trend toward faster closure. Similarly, voluntary exercise did not significantly alter healing rates in rats. Thus, impaired wound healing appears to be a generalized physiological manifestation of aging, but its possible amelioration by "anti-aging" interventions remains to be established.
Roth
G S
GS
Laboratory of Cellular and Molecular Biology, National Institute on Aging, Baltimore, USA. geor@vax.grc.nia.nih.gov
Kowatch
M A
MA
Hengemihle
J
J
Ingram
D K
DK
Spangler
E L
EL
Johnson
L K
LK
Lane
M A
MA
D000375:Aging / Q000502:physiology*; D000818:Animals; D002149:Energy Intake; D008253:Macaca mulatta; D008297:Male; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000293:injuries*; D014945:Wound Healing / Q000502:physiology*; D014950:Wounds, Penetrating / Q000503:physiopathology*