31P NMR spectroscopy in oligonucleotide research and development.
31P NMR is an extremely valuable tool for oligonucleotide research and development. This brief commentary, which is directed to scientists who do not regularly use 31P NMR in their work, attempts to outline some of the principles, considerations, and representative applications of 31P NMR spectroscopy in oligonucleotide research and development.
Hirschbein
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BL
Lynx Therapeutics, Hayward, California 94545, USA.
Fearon
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KL
D004355:Drug Stability; D007553:Isotope Labeling; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009841:Oligonucleotides / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry*; D010759:Phosphorus Isotopes; D011786:Quality Control
D009841:Oligonucleotides; D010759:Phosphorus Isotopes