[Clinical investigation of the action of tramazoline inpatients with chronic obstructive bronchitis. The importance of mucosal swelling].
Swelling of the bronchial mucosa is discussed as part of the increased airways on patients with obstructive bronchitis (OB). The excellent effect of alpha-receptor-stimulants like tramazoline for the deblockage of the nasal mucosa has been previously established experimentally as well as clinically. On 19 patients with OB tramazoline (CAS 74195-73-6) aerosol (Rhinospray) (0.14 (n = 9) resp. 0.19 (n = 10 mg) was administered into the bronchial system. There were no effects seen on airways resistance nor on the intrathoracic gas volume. The important improvement on patients with OB and nasal blockage at the same time seen after tramazoline aerosol given into the nose is caused only by the effect on the nasal mucosa.
Schött
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Medizinische Klinik des Kreiskrankenhauses Siegen, Lungenfunktionsforschung Bochum.
Ulmer
W T
WT
D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D000403:Airway Resistance; D001784:Blood Gas Analysis; D001991:Bronchitis / Q000188:drug therapy* / Q000473:pathology*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002908:Chronic Disease; D004487:Edema / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000187:drug effects / Q000473:pathology
D001993:Bronchodilator Agents; D007093:Imidazoles; C005370:tramazoline
Klinische Untersuchungen zur Wirkung von Tramazolin bei Patienten mit chronisch obstruktiver Bronchitis. Ein Beitrag zur Bedeutung der Schleimhaustschwellung.