Lessons from coronary atherosclerosis "regression" trials.
This article describes the background and methodology of the published studies assessing the effects of cholesterol-lowering therapy and of treatment of multiple risk factors on the progression of coronary atherosclerosis. The results are then presented, followed by a discussion of the lessons that can be learned from this large series of similar trials.
Waters
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Division of Cardiology, Hartford Hospital 06102-5037, USA.
D002986:Clinical Trials as Topic; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000178:diet therapy* / Q000473:pathology* / Q000503:physiopathology; D003331:Coronary Vessels / Q000473:pathology / Q000503:physiopathology; D004036:Diet, Atherogenic; D018450:Disease Progression; D006801:Humans; D011379:Prognosis; D012307:Risk Factors