Antibacterial activity of T-5575, a novel 2-carboxypenam, and its stability to beta-lactamase.
The in-vitro activity of T-5575, 2-carboxypenam, a new parenteral antibiotic and its stability to beta-lactamases were compared with those of ceftazidime and imipenem. The activity of T-5575 was equal or superior to that of ceftazidime or imipenem against Gram-negative bacteria that produced penicillinase with the exception of the enzyme OXA-1. Against strains that produced Cephalosporinase and zinc-dependent beta-lactamase, the activity of T-5575 was superior to that of ceftazidime or imipenem. T-5575 was a poor substrate and had low affinity for beta-lactamases produced by Citrobacter freundii, Enterobacter cloacae and Pseudomonas aeruginosa. The activity of T-5575 was less influenced by the derepressed production of chromosomal enzymes than that of ceftazidime. Overall, T-5575 had excellent activity against Gram-negative pathogens that produced various types of beta-lactamases.
Matsumura
N
N
Episome Institute, Gunma, Japan.
Minami
S
S
Mitsuhashi
S
S
D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D015780:Carbapenems / Q000378:metabolism / Q000494:pharmacology; D002442:Ceftazidime / Q000378:metabolism / Q000494:pharmacology; D002511:Cephalosporins / Q000378:metabolism / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000201:enzymology / Q000235:genetics; D006868:Hydrolysis; D015378:Imipenem / Q000378:metabolism / Q000494:pharmacology; D007700:Kinetics; D009154:Mutation; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D002511:Cephalosporins; C097413:T 5575; D047090:beta-Lactams; D015378:Imipenem; D002442:Ceftazidime; D001618:beta-Lactamases