title: Estimation of 99Tcm-MAG3 clearance using a single blood sample obtained over a continuous time interval.
abstract: Simplified methods based on a single blood sample have been proposed to estimate the clearance of 131I-hippuran (HIP) and 99Tcm-mercaptoacetyltriglycine (MAG). The blood sample is usually drawn at that time which yields a minimum error between the estimated clearance and that obtained by the standard nine-sample method. In this paper, we establish the regression equations to obtain the HIP and MAG clearances using one sample withdrawn during a fixed time interval. As HIP has long been the agent of choice, we have also established regression equations to estimate the clearance of HIP using one sample after MAG administration. Our results suggest that it is possible to obtain plasma samples 30-50 min post-injection which result in an error of the estimate only slightly higher than the minimum.
authors.affiliation: Servicio de Medicina Nuclear, Hospital Clínic i Provincial, Barcelona, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Piera
authors.forename: D
authors.initials: D
authors.lastname: Ros
authors.forename: J
authors.initials: J
authors.lastname: Pavia
authors.forename: D
authors.initials: D
authors.lastname: Fuster
authors.forename: A
authors.initials: A
authors.lastname: Muxi
mesh_terms: D000328:Adult; D001800:Blood Specimen Collection; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D007465:Iodohippuric Acid / Q000493:pharmacokinetics; D007674:Kidney Diseases / Q000175:diagnosis* / Q000503:physiopathology*; D008657:Metabolic Clearance Rate; D012016:Reference Values; D012044:Regression Analysis; D015203:Reproducibility of Results; D017263:Technetium Tc 99m Mertiatide / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors
chemical_list: D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D017263:Technetium Tc 99m Mertiatide