Free radical scavenging activities of mushroom polysaccharide extracts.
The superoxide and hydroxyl radical scavenging activities of eight mushroom antitumor polysaccharide extracts were investigated using phenazin methosulphate-NADH-nitroblue tetrazolium system and ascorbic acid-Cu(2+)-cytochrome C system respectively. The results showed that six of eight mushroom polysaccharide extracts had superoxide and hydroxyl radical scavenging activities. The protein content of the polysaccharide extracts appeared to contribute a direct effect on free radical scavenging activity. However, none of the mushroom polysaccharide extracts had antioxidative activity as measured by detecting malondialdehyde (MDA) contents of liver microsomes.
Liu
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Department of Biology, Chinese University of Hong Kong, Shatin, N. T., Hong Kong.
Ooi
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Chang
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D000970:Antineoplastic Agents / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology*; D005656:Fungal Proteins / Q000032:analysis; D017665:Hydroxyl Radical / Q000378:metabolism*; D007912:Lentinan / Q000737:chemistry / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000378:metabolism; D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology*; D011509:Proteoglycans / Q000737:chemistry / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism*
D000970:Antineoplastic Agents; D016166:Free Radical Scavengers; D005656:Fungal Proteins; D011134:Polysaccharides; D011509:Proteoglycans; D013481:Superoxides; D017665:Hydroxyl Radical; D007912:Lentinan; C010770:polysaccharide-K; D008315:Malondialdehyde