title: [Lichen planus associated with liver disease caused by hepatitis C virus].
abstract: The association between lichen planus (LP) and liver disease by the hepatitis C virus (HCV) has recently been described although its significance is controversial. The charts of 10 patients (8 women, 2 men) clinically and/or histologically diagnosed of LP and with positive HCV serology were retrospectively reviewed. Nine of the patients presented mucosal involvement, four of which were of the erosive form. In 7 patients liver disease preceded the appearance of LP. In the remaining 3 patients HCV infection was detected after the diagnosis of LP despite no alterations being observed in the liver function tests in 2 cases. Alpha-interferon 2b treatment triggered the lesions in 3 cases while leading to resolution of LP in another case. These data confirm the findings referred in the references and support the direct or indirect participation of HCV in LP.
authors.affiliation: Servicio de Dermatología, Hospital General Vall d'Hebron, Barcelona.
authors.forename: L
authors.initials: L
authors.lastname: Jáuregui
authors.forename: V
authors.initials: V
authors.lastname: García-Patos
authors.forename: R
authors.initials: R
authors.lastname: Pedragosa
authors.forename: J
authors.initials: J
authors.lastname: Vidal
authors.forename: A
authors.initials: A
authors.lastname: Castells
mesh_terms: D000368:Aged; D005260:Female; D006526:Hepatitis C / Q000150:complications* / Q000628:therapy; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D008010:Lichen Planus / Q000209:etiology* / Q000473:pathology; D017676:Lichen Planus, Oral / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D011994:Recombinant Proteins; D012189:Retrospective Studies; D012867:Skin / Q000473:pathology
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins
vernacular_title: Liquen plano asociado a hepatopatía por virus de la hepatitis C.