[The role of the cells of the hepatic sinusoid in regulating protein biosynthesis in hepatocytes].
The protein synthesis in hepatocytes has been shown to be regulated by nonparenchymal (sinusoidal) liver cells. The rate of 14C-leucine incorporation into hepatic proteins and serum proteins was increased during in vivo stimulation of Kupffer cells by lipopolysaccharide (LPS) from Serratia marcescens. Similar results were obtained during a simultaneous cultivation of hepatocytes with nonparenchymal cells, and after the cultivation of hepatocytes in a conditioned medium containing nonparenchymal cells treated with LPS, high density lipoprotein (HDL) and hydrocortisone. The induction of protein synthesis in hepatocytes is presumably associated with the cooperative action of HDL and glucocorticoids.
Panin
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Usynin
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Khar'kovskiĭ
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D000818:Animals; D002196:Capillaries / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D002250:Carbon Radioisotopes; D018929:Cell Culture Techniques / Q000379:methods; D002478:Cells, Cultured; D005260:Female; D007728:Kupffer Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D007930:Leucine / Q000378:metabolism; D008099:Liver / Q000098:blood supply*; D014176:Protein Biosynthesis; D011506:Proteins / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013268:Stimulation, Chemical
D002250:Carbon Radioisotopes; D011506:Proteins; D007930:Leucine
Rol' kletok pechenochnogo sinusoida v reguliatsii biosinteza belka v gepatotsitakh.