[The cytogenetic activity of some brands of epoxy resins].
The studies have allow us to ascertain that some epoxy resins, such as DE-500, DE-1000, DE-2000, UP-650, UP-650T, under gastric administration at the dose levels of 1/10 and 1/50 DL50 (DL50 = 5338 +/- 1134, 6644 +/- 1114, 9180 +/- 1154, 7717 +/- 586, 6980 +/- 621 mg/kg for DE-500, DE-1000, DE-2000, UP-650, UP-650T respectively) and ED-22F under inhalational exposure at 1 mg/m3 as per epichlorhydrine over three to four months, have a striking effect on the chromosomal apparatus of the laboratory animals bone marrow cells, bringing about chromosomal structural aberrations. The cytogenetic activity was found to be dependent upon the dose employed as well as duration of the exposure and chemical structure of the epoxy resins.
Iavorovskiĭ
A P
AP
Bariliak
I R
IR
Paustovskiĭ
Iu A
IuA
D000280:Administration, Inhalation; D000284:Administration, Oral; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D004853:Epoxy Resins / Q000008:administration & dosage / Q000633:toxicity*; D007928:Lethal Dose 50; D009153:Mutagens / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D013270:Stomach / Q000187:drug effects; D013997:Time Factors
D004853:Epoxy Resins; D009153:Mutagens
O tsitogeneticheskoĭ aktivnosti nekotorykh marok époksidnykh smol.