Case study: two additional sudden deaths with tricyclic antidepressants.
Since 1990, there have been five reported cases of sudden death in children treated with desipramine. This case study describes the sudden deaths of two additional children treated with tricyclic antidepressants, one with desipramine, 3.3 mg/kg per day, the other with imipramine, 6 mg/kg per day and thioridazine, 1 mg/kg per day. The reports add to concerns about the use of tricyclics in children.
Varley
C K
CK
Division of Child and Adolescent Psychiatry, University of Washington, Seattle, USA.
McClellan
J
J
D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D014150:Antipsychotic Agents / Q000009:adverse effects; D002648:Child; D003645:Death, Sudden / Q000209:etiology*; D003891:Desipramine / Q000009:adverse effects*; D006801:Humans; D007099:Imipramine / Q000009:adverse effects*; D008297:Male; D013881:Thioridazine / Q000009:adverse effects
D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D013881:Thioridazine; D007099:Imipramine; D003891:Desipramine