title: cDNA cloning and immunological characterization of rabbit p53.
abstract: We have cloned and sequenced the p53-encoding rabbit cDNA (Oryctolagus cuniculus). The encoded product is 86% and 80% homologous to human and mouse p53, respectively. It features many characteristics found in all p53 proteins: (i) the five domains highly conserved during evolution, (ii) an acidic N terminus, (iii) a hydrophilic C terminus and (iv) a penultimate serine residue. Immunoprecipitation of the cDNA-encoded protein by monoclonal antibodies specific for mammalian p53 has confirmed the identity of the protein.
authors.affiliation: U64 INSERM, Hôpital Tenon, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Le Goas
authors.forename: P
authors.initials: P
authors.lastname: May
authors.forename: P
authors.initials: P
authors.lastname: Ronco
authors.forename: C
authors.initials: C
authors.lastname: Caron de Fromentel
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D003429:Cross Reactions; D018076:DNA, Complementary / Q000235:genetics; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D011233:Precipitin Tests; D011817:Rabbits / Q000235:genetics*; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000276:immunology*
chemical_list: D018076:DNA, Complementary; D016159:Tumor Suppressor Protein p53