Effect of 3-[p-(N-2-pyrimidylsulfamoyl)phenyl hydrazono]pentane-2,4-dione on blood parameters of albino rats.
Intramuscular injection of 3-[p-(N-2-pyrimidylsulfamoyl)phenylhydrazono]pentane-2,4-dio ne (compound I) resulted in decrease in haemoglobin and alanine transaminase (ALT) and increase in aspartate transaminase (AST) values in albino rats. The serum glucose was found to decrease and after administration of 14 doses of 5.4 mg kg-1 body wt glucose level also declined significantly. It is concluded that the compound I is a better hypoglycemic than sulfonamide or hydrazone alone.
Goyal
R N
RN
Department of Chemistry, University of Roorkee, India.
Garg
D K
DK
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001806:Blood Urea Nitrogen; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D011743:Pyrimidines / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats
C105897:3-(4-(N-2-pyrimidylsulfamoyl)phenylhydrazono)pentane-2,4-dione; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D011743:Pyrimidines; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase