title: Absorption of ciprofloxacin and norfloxacin when administered as niosome-encapsulated inclusion complexes.
abstract: An attempt has been made to design suitable niosome-encapsulated drug delivery system for ciprofloxacin and norfloxacin. Encapsulation of ciprofloxacin and norfloxacin in niosomes was investigated and the nasal and intestinal absorption of the products studied. More than 80% of the drugs were successfully encapsulated to give products with sustained release characteristics. Encapsulation in niosomes also improved the stability of the antibacterial compounds. Although the systemic availability of these niosome-encapsulated antibacterial compounds was not increased after nasal administration, intestinal absorption was significantly higher in comparison with that of plain inclusion complexes.
authors.affiliation: College of Pharmaceutical Sciences, Manipal, India.
authors.forename: S A
authors.initials: SA
authors.lastname: D'Souza
authors.forename: J
authors.initials: J
authors.lastname: Ray
authors.forename: S
authors.initials: S
authors.lastname: Pandey
authors.forename: N
authors.initials: N
authors.lastname: Udupa
mesh_terms: D000042:Absorption; D000281:Administration, Intranasal; D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003505:Cyclodextrins; D004337:Drug Carriers; D004355:Drug Stability; D008081:Liposomes; D009643:Norfloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D013696:Temperature; D047392:beta-Cyclodextrins
chemical_list: D000890:Anti-Infective Agents; D003505:Cyclodextrins; D004337:Drug Carriers; D008081:Liposomes; D047392:beta-Cyclodextrins; D002939:Ciprofloxacin; C031215:betadex; D009643:Norfloxacin