title: Efficacy of prophylactic vena cava filters in high-risk trauma patients.
abstract: Severely injured trauma patients are at increased risk of pulmonary embolism (PE). Certain injuries may preclude the use of standard prophylactic measures, and even when used, these measures may be ineffective in the trauma population. We defined a group of trauma patients who are at statistically elevated risk of venous thromboembolic events. We then adopted an aggressive approach to the placement of prophylactic inferior vena cava (IVC) filters in these high-risk patients. Between January 1994 and January 1996 we treated 250 trauma patients who met our high-risk criteria. Prophylactic IVC filters were placed in 99 of these patients, and 151 received deep venous thrombosis prophylaxis with either heparin, sequential compression stockings, or a combination of these modalities. High-risk patients did not receive filters if they were unlikely to survive or showed rapid clinical improvement and were felt to not remain at high risk. The incidence of pulmonary embolism in this high-risk population was 1.6%. This is a significant reduction (p = 0.045, Fisher exact test) from the 4.8% incidence of PE in high-risk historical control patients with similar injury profiles. No patient with a prophylactic IVC filter suffered a clinically evident PE and there were no complications associated with placement of these filters. We conclude that the placement of prophylactic IVC filters in high-risk trauma patients is a safe and effective method of reducing the incidence of pulmonary embolism.
authors.affiliation: Department of Surgery, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Gosin
authors.forename: A M
authors.initials: AM
authors.lastname: Graham
authors.forename: R G
authors.initials: RG
authors.lastname: Ciocca
authors.forename: J S
authors.initials: JS
authors.lastname: Hammond
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D001458:Bandages; D016022:Case-Control Studies; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D015994:Incidence; D008297:Male; D011655:Pulmonary Embolism / Q000453:epidemiology / Q000517:prevention & control*; D012307:Risk Factors; D013924:Thrombophlebitis / Q000453:epidemiology / Q000517:prevention & control; D016306:Vena Cava Filters; D014947:Wounds and Injuries / Q000150:complications*
chemical_list: D000925:Anticoagulants; D006493:Heparin