[Altered calcium homeostasis in chronic heart failure].
Intracellular calcium homoeostasis is greatly altered in heart failure. This does not seem to be due to altered calcium influx through L-type calcium channels but rather due to altered calcium uptake mechanisms of the sarcoplasmic reticulum. Recently, a negative force-frequency behaviour of the human myocardium has been detected in hearts from patients with severe heart failure. In the myocardium from these patients, SR-Ca(2+)-ATPase activity was decreased. The same defect has been reported in human isolated cardiac myocytes. A disturbed calcium release from the SR may also contribute to this finding of the inverse force-frequency-relationship in the failing myocardium. The altered intracellular calcium handling is connected with the diastolic and systolic failure of the myocardium. Mg++ and Na(+)-channel modulators are able to restore the positive force-frequency-relationship even in severely failing myocardium.
Erdmann
E
E
Klinik III für Innere Medizin, Universität zu Köln.
Schwinger
R H
RH
Beuckelmann
D
D
Böhm
M
M
D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000502:physiology*; D000252:Calcium-Transporting ATPases / Q000502:physiology; D046508:Culture Techniques; D006333:Heart Failure / Q000503:physiopathology*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology; D009206:Myocardium / Q000201:enzymology; D010210:Papillary Muscles / Q000503:physiopathology; D012519:Sarcoplasmic Reticulum / Q000502:physiology
D015220:Calcium Channels; D000252:Calcium-Transporting ATPases; D002118:Calcium
Die gestörte Kalzium-Homöostase bei chronischer Herzinsuffizienz.