title: Imaging of delta- and mu-opioid receptors in temporal lobe epilepsy by positron emission tomography.
abstract: The involvement of opioid neurotransmitter systems in seizure mechanisms is well documented. In previous positron emission tomography (PET) studies in patients with unilateral temporal lobe epilepsy, we have found evidence for differential regulation of the opioid-receptor subtypes. The present study extends our previous observations to delta-opioid receptors by using the delta-receptor-selective antagonist [11C]methylnaltrindole ([11C]MeNTI). Paired measurements of delta- and mu-opioid receptor binding and metabolic activity were performed with PET using [11C]MeNTI and [11C]carfentanil ([11C]CFN) and [18F]fluorodeoxyglucose ([18F]FDG), respectively. Binding of [11C]MeNTI and [11C]CFN increased and [18F]FDG uptake decreased in the temporal cortex (TC) ipsilateral to the focus. Decreases in [18F]FDG uptake were more widespread regionally than were increases in opioid receptors. Increases in the delta- and mu-receptor binding showed different regional patterns. Increases in mu-receptor binding were confined to the middle aspect of the inferior TC, whereas binding of delta receptors increased in the mid-inferior TC and anterior aspect of the middle and superior TC. The increase in delta receptors suggests their anticonvulsant action, as previously shown for the delta-receptor subtype, whereas the different regional pattern of receptor alterations suggest the distinct roles of different opioid-receptor subtypes in seizure phenomena.
authors.affiliation: Department of Radiology, Johns Hopkins University, Baltimore, MD 21287, USA.
authors.forename: I
authors.initials: I
authors.lastname: Madar
authors.forename: R P
authors.initials: RP
authors.lastname: Lesser
authors.forename: G
authors.initials: G
authors.lastname: Krauss
authors.forename: J K
authors.initials: JK
authors.lastname: Zubieta
authors.forename: J R
authors.initials: JR
authors.lastname: Lever
authors.forename: C M
authors.initials: CM
authors.lastname: Kinter
authors.forename: H T
authors.initials: HT
authors.lastname: Ravert
authors.forename: J L
authors.initials: JL
authors.lastname: Musachio
authors.forename: W B
authors.initials: WB
authors.lastname: Mathews
authors.forename: R F
authors.initials: RF
authors.lastname: Dannals
authors.forename: J J
authors.initials: JJ
authors.lastname: Frost
mesh_terms: D000328:Adult; D000679:Amygdala / Q000378:metabolism; D000704:Analysis of Variance; D001284:Atrophy; D001665:Binding Sites; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging* / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017465:Receptors, Opioid, delta / Q000378:metabolism*; D017450:Receptors, Opioid, mu / Q000378:metabolism*; D014055:Tomography, Emission-Computed; D015854:Up-Regulation
chemical_list: D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu; D005947:Glucose