title: Marigenol-concentrates comprising Taxol and/or Taxan esters as active substances.
abstract: Marigen is a Swiss Research Company based in Riehen (Canton of Basle). It has developed and tested a Solubilization System for its phytosteryl ester compounds having antitumor and antiviral/virucidal activity. By formulating spontaneously dispersible concentrates, which comprise such compounds, it is now possible to produce thermodynamically stable, aqueous ultramicroemulsions which achieve outstanding bioavailability and bio-reactivity for the active principles comprised in these Marigenol-Concen-trates. As a consequence, unwanted side-effects are drastically reduced in therapeutical use or even completely absent, and the economy of the system permits a remarkable optimization of the dose-efficacy relationship and hence also of drug safety.
authors.affiliation: Marigen S.A., Riehen.
authors.forename: C
authors.initials: C
authors.lastname: Eugster
authors.forename: G
authors.initials: G
authors.lastname: Rivara
authors.forename: G
authors.initials: G
authors.lastname: Forni
authors.forename: S
authors.initials: S
authors.lastname: Vai
mesh_terms: D000470:Alkaloids / Q000008:administration & dosage* / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry*; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004655:Emulsions; D006801:Humans; D017239:Paclitaxel / Q000008:administration & dosage* / Q000737:chemistry*; D014677:Pharmaceutical Vehicles / Q000008:administration & dosage* / Q000737:chemistry*; D010840:Phytosterols / Q000737:chemistry; D012995:Solubility; D043823:Taxoids
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D004655:Emulsions; D014677:Pharmaceutical Vehicles; D010840:Phytosterols; D043823:Taxoids; C073950:baccatin III; D017239:Paclitaxel