Enhancement of the locomotor response to apomorphine in pertussis toxin-treated animals depends on the site of pertussis toxin injection into the ventral tegmental area.
The locomotor stimulant response to either systemic or intra-accumbens amphetamine was enhanced 1-2 weeks after pre-treatment with pertussis toxin (PTX) into any of 3 different sites in the ventral tegmental area (VTA). An enhanced response to either systemic or intra-accumbens apomorphine occurred only after pre-treatment into the central VTA. Thus, enhanced sensitivity to drugs of either pre- or post-synaptic elements in the nucleus accumbens may develop depending on the site of the PTX pre-treatment within the VTA.
Narayanan
S
S
Division of Pharmacology, College of Pharmacy, Ohio State University, Columbus 43210, USA.
Dalia
A
A
Wallace
L J
LJ
Uretsky
N J
NJ
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D018491:Dopamine Agonists / Q000494:pharmacology*; D004357:Drug Synergism; D007267:Injections; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D037342:Pertussis Toxin; D051381:Rats; D017207:Rats, Sprague-Dawley; D013681:Tegmentum Mesencephali / Q000502:physiology*; D010566:Virulence Factors, Bordetella / Q000008:administration & dosage* / Q000494:pharmacology
D018491:Dopamine Agonists; D010566:Virulence Factors, Bordetella; D037342:Pertussis Toxin; D001058:Apomorphine