[The pharmacokinetics of D-lactate, L-lactate and acetate in humans].
In this study, the pharmacokinetics of D-lactate, L-lactate and acetate were investigated in 36 adult surgical patients. After induction of general anaesthesia, the subjects received intravenous injection of either 5 mmoles of D-lactate and 5 mmoles of L-lactate simultaneously (Group DL), 10 mmoles of L-lactate (Group L), or 10 mmoles of acetate (Group A). Serial arterial blood samples were obtained before the injection, and 3, 5, 7, 9 and 11 minutes after the infusion of each preparation. Plasma concentrations of D-lactate, L-lactate and acetate were measured by high performance liquid chromatography, enzymatic analysis and spectrophotometry. The pharmacokinetic parameters; distribution volume (Vd) and half-life (t1/2) were calculated with a one-compartment model from the incremental plasma concentration decay curve after administration. In Group DL, there were no differences between D-lactate and L-lactate in Vd and t1/2. Also, between L-lactate in Group DL and that in Group L, there were no differences in Vd and t1/2. The Vd and T1/2 of acetate, however, were smaller than those of L-lactate in Group L. We conclude that the pharmacokinetics of D-lactate is similar to those of L-lactate, and that acetate may be metabolized more rapidly than L-lactate.
Hamada
T
T
Department of Anesthesiology, Faculty of Medicine, Toyama Medical and Pharmaceutical University.
Yamamoto
M
M
Nakamaru
K
K
Iwaki
K
K
Ito
Y
Y
Koizumi
T
T
D019342:Acetic Acid / Q000097:blood / Q000493:pharmacokinetics*; D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D005260:Female; D006207:Half-Life; D006801:Humans; D007552:Isotonic Solutions / Q000493:pharmacokinetics*; D019344:Lactic Acid / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D000077325:Ringer's Lactate; D013237:Stereoisomerism
D007552:Isotonic Solutions; D000077325:Ringer's Lactate; C028570:Ringer's acetate; D019344:Lactic Acid; D019342:Acetic Acid