Efficacy of decoquinate against Neospora caninum tachyzoites in cell cultures.
Neospora caninum is a major cause of abortion in dairy cattle in the United States and other countries. Abortions and neonatal mortality also occur in other ruminant species. Decoquinate is an anticoccidial that is approved for use in cattle and goats in the United States. We studied the efficacy of decoquinate against tachyzoites of N. caninum in a 5-day of treatment, cell culture flask lesion-based assay. Decoquinate killed tachyzoites at concentrations of 0.1 and 0.01 microgram ml-1. Decoquinate had little measurable effect on extracellular tachyzoites. Decoquinate acted quickly to kill intracellular stages at coccidiocidal concentrations; tachyzoites were killed within 5 min at 0.1 microgram ml-1 decoquinate.
Lindsay
D S
DS
Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849-5519, USA.
Butler
J M
JM
Blagburn
B L
BL
D000034:Abortion, Veterinary; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases; D002478:Cells, Cultured; D003048:Coccidiosis / Q000150:complications / Q000662:veterinary; D003049:Coccidiostats / Q000494:pharmacology*; D003667:Decoquinate / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007814:Larva; D008297:Male; D018688:Neospora / Q000187:drug effects*; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000662:veterinary; D012418:Ruminants; D012867:Skin
D003049:Coccidiostats; D003667:Decoquinate