Functional echoplanar brain imaging correlates of amphetamine administration to normal subjects and subjects with the narcoleptic syndrome.
Two subjects with narcoleptic syndrome and three healthy volunteers underwent functional magnetic resonance imaging during the simultaneous presentation of periodic auditory and visual stimuli both before and after administration of amphetamine. The effect of amphetamine in control subjects was a small reduction in the extent of sensory-induced activation. In the narcoleptic subjects, amphetamine led to an increase in the extent of induced activation within primary and association sensory cortex.
Howard
R J
RJ
Department of Old Age Psychiatry, Institute of Psychiatry, Camberwell, London, UK.
Ellis
C
C
Bullmore
E T
ET
Brammer
M
M
Mellers
J D
JD
Woodruff
P W
PW
David
A S
AS
Simmons
A
A
Williams
S C
SC
Parkes
J D
JD
D000161:Acoustic Stimulation; D000328:Adult; D000661:Amphetamine / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology*; D001931:Brain Mapping; D017352:Echo-Planar Imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000175:diagnosis / Q000503:physiopathology*; D010775:Photic Stimulation
D000661:Amphetamine