[A patient with an unexplained low level of high density lipoprotein cholesterol].
A non smoking male patient 42 years old complained of pain in the calves after exercise and had a low 'high density'-lipoprotein (HDL) cholesterol serum concentration. Angiography of the leg vessels revealed no abnormalities. Treatment with simvastatin and gemfibrozil did not affect HDL cholesterol concentrations. Blood tests of relatives made familial hypo-alpha-lipoproteinaemia unlikely. It appeared that the patient had used anabolic steroids; these increase hepatic lipase activity leading to a higher metabolism of HDL and reduced HDL cholesterol levels.
Castro Cabezas
M
M
Afd. Interne Geneeskunde, St. Antonius Ziekenhuis, Nieuwegein.
van Loon
D
D
de Hiep
H J
HJ
Meuwissen
O J
OJ
D000328:Adult; D045930:Anabolic Agents / Q000009:adverse effects / Q000494:pharmacology*; D008076:Cholesterol, HDL / Q000097:blood* / Q000378:metabolism; D006801:Humans; D007009:Hypolipoproteinemias / Q000097:blood* / Q000235:genetics; D008049:Lipase / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008297:Male; D010375:Pedigree
D045930:Anabolic Agents; D008076:Cholesterol, HDL; D008049:Lipase
Een patiënt met een onbegrepen lage concentratie 'high-density'-lipoproteïnecholesterol.