title: Subretinal aspiration biopsy of ocular lymphoma.
abstract: OBJECTIVE
  Large-cell lymphoma can be difficult to diagnose because vitreous biopsies may fail to disclose neoplastic cells.
  
  
  METHODS
  We report one such case in which diagnosis was confirmed by subretinal aspiration of yellow-white infiltrates using a pars plana approach.
  
  
  RESULTS
  A 67-year-old woman with recurrent bilateral uveitis was diagnosed with large-cell lymphoma by subretinal aspiration of yellow-white infiltrates after two vitreous biopsies and a concurrent retinal biopsy failed to confirm the diagnosis.
  
  
  CONCLUSIONS
  When the suspicion of intraocular lymphoma remains high despite previous negative vitreous biopsies, retinal biopsy and aspiration biopsy of subretinal lesions may enhance the diagnostic yield.
authors.affiliation: Department of Ophthalmology, Indiana University School of Medicine, USA.
authors.forename: T A
authors.initials: TA
authors.lastname: Ciulla
authors.forename: R D
authors.initials: RD
authors.lastname: Pesavento
authors.forename: S
authors.initials: S
authors.lastname: Yoo
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D001707:Biopsy, Needle; D003561:Cytarabine / Q000627:therapeutic use; D004322:Drainage / Q000379:methods; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy; D012160:Retina / Q000473:pathology*; D012164:Retinal Diseases / Q000175:diagnosis* / Q000628:therapy; D014792:Visual Acuity
chemical_list: D000964:Antimetabolites, Antineoplastic; D003561:Cytarabine