Synthesis of some new quinazolines and quinoxalines of potential antiinflammatory activity.
A number of quinazoline derivatives containing basic amine substituents at position 4, as well as new derivatives of triazolo[4,3-alpha]quinoxalines carrying basic amine or carboxylic acid moieties have been synthesized. A tetracyclic imidazotriazoloquinoxaline compound is also reported. Two of the new products (2b and 7b) exhibited good antiinflammatory activity in rats, although inferior to that of indomethacin.
el-Bendary
E R
ER
Dept. of Medicinal Chemistry, Faculty of pharmacy, University of Mansoura, Egypt.
el-Ashmawy
M B
MB
Barghash
A M
AM
Shehata
I A
IA
el-Kerdawy
M M
MM
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011799:Quinazolines; D011810:Quinoxalines; D002351:Carrageenan