[Diagnosis of Epstein-Barr virus-associated gastric carcinoma and its background gastric mucosa].
Recently, the presence of Epstein-Barr virus(EBV) in almost 7% of gastric carcinoma lesions was reported. From our observation, EBV-associated gastric carcinomas located mainly in the gastric body, and moderate to poorly differentiated adenocarcinoma with lymphoid infiltration, as currently reported. Macroscopically, there were mainly thick and ulcerated lesions, EBV-associated gastric carcinomas had close relation with intestinal metaplasia, and EBV could be suspected to provide the immortalized epithelial cells.
Yanai
H
H
First Department of Internal Medicine, Yamaguchi University School of Medicine.
Mizugaki
Y
Y
Nishikawa
J
J
Tada
M
M
Okita
K
K
Shimizu
N
N
Takada
K
K
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology; D005753:Gastric Mucosa / Q000473:pathology; D006566:Herpesviridae Infections / Q000473:pathology*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology; D014412:Tumor Virus Infections / Q000473:pathology*