title: Regulation of cell signaling by the protein tyrosine phosphatases, CD45 and SHP-1.
abstract: An equilibrium between positive and negative regulation of immunoreceptor signaling leads to the proper execution of lymphocyte activation. Tyrosine phosphorylation is the initial event in antigen receptor-induced lymphocyte activation. It is generally accepted that protein tyrosine kinases are involved in positive regulation, whereas protein tyrosine phosphatases are important for the negative regulation of tyrosine phosphorylation-dependent processes. However, the interaction between protein tyrosine kinases and protein tyrosine phosphatases is complex. This article discusses the role of two protein tyrosine phosphatases. CD45 and SHP-1, in the regulation of immunoreceptor signaling. SHP-1 acts as a negative regulator for several immunoreceptors, including those for T- and B-cell antigen receptors. The major role of CD45 is in the positive regulation of T- and B-cell antigen receptor signaling.
authors.affiliation: Washington University, School of Medicine, Department of Pathology, St. Louis MO 63110, USA.
authors.forename: T
authors.initials: T
authors.lastname: Ulyanova
authors.forename: J
authors.initials: J
authors.lastname: Blasioli
authors.forename: M L
authors.initials: ML
authors.lastname: Thomas
mesh_terms: D000818:Animals; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases / Q000276:immunology* / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C516724:PTPN11 protein, human; C509249:PTPN6 protein, human; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases