title: Complete remission following donor PBSC after low-dose cytarabine chemotherapy for early relapse of acute myelogenous leukemia after allogeneic stem cell transplantation.
abstract: A 55-year-old woman with chemotherapy-resistant acute myeloblastic leukemia (AML M2) relapsed 3 months after allogeneic PBSC transplant. The patient was treated with two cycles of low-dose cytarabine chemotherapy followed by G-CSF mobilized donor PBSC after cessation of all immunosuppressive treatment. Hematological and cytogenetic complete remission was observed after the first cycle. The patient had been previously treated for AGVHD after allogeneic PBSC transplantation and experienced a second AGVHD after the second cycles of cytoreductive treatment and donor PBSC infusion. Hematological recovery after donor PBSC infusion was faster than recovery after previous chemotherapy or high-dose chemotherapy. During treatment no febrile neutropenia was observed. This case shows that donor PBSC infusion cannot only provide prolonged complete hematological and cytogenetic remission but also seems to support accelerated hematopoietic recovery for some patients relapsing after allogeneic BMT.
authors.affiliation: Institut J Bordet, Service de Médecine Interne et Laboratoire d'Investigation, Clinique H Tagnon, Brussels, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Trenschel
authors.forename: M
authors.initials: M
authors.lastname: Bernier
authors.forename: P
authors.initials: P
authors.lastname: Stryckmans
authors.forename: A
authors.initials: A
authors.lastname: Verhest
authors.forename: R
authors.initials: R
authors.lastname: Badjou
authors.forename: P
authors.initials: P
authors.lastname: Crombez
authors.forename: D
authors.initials: D
authors.lastname: Bron
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D003561:Cytarabine / Q000008:administration & dosage*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000628:therapy*; D008875:Middle Aged; D012074:Remission Induction; D014184:Transplantation, Homologous
chemical_list: D000964:Antimetabolites, Antineoplastic; D003561:Cytarabine