title: Haemostasis during infrarenal aortic aneurysm surgery: effect of volume loading and cross-clamping.
abstract: OBJECTIVE
  To study thrombin and plasmin activation during elective abdominal aortic aneurysm surgery.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  University Hospital.
  
  
  METHODS
  Nine consecutive patients undergoing elective surgery were included. The mean age was 72 years (range 60-79). Blood samples were drawn: (1) before induction of anaesthesia; (2) after induction and Swan Ganz catherisation; (3) just before cross-clamping; (4) before declamping; (5) 8 h postoperatively; (6) 18 h postoperatively.
  
  
  METHODS
  Assays included: prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, prothrombin fragments (F 1 + 2), anti-thrombin III (ATIII), plasminogen, alpha 2-antiplasmin, haematocrit, platelet and serum protein for correction of haemodilution. Data were expressed as mean (S.D.). Differences between mean values were tested by means of the ANOVA for repeated measures and the Wilcoxon signed rank test.
  
  
  RESULTS
  The APTT and TT did not change until heparinisation. The F 1 + 2 were already elevated preoperatively. After correction for haemodilution the AT III and alpha 2-antiplasmin decreased in time (p = 0.009 and 0.0023, respectively) and the F1 + 2 increased (p < 0.0001). Postoperatively (t5 and 6) the values normalised again.
  
  
  CONCLUSIONS
  The coagulation and fibrinolytic systems are activated during and after elective aortic replacement. Standard tests, like the prothrombin and partial thromboplastin time, are unreliable when assessing the coagulation status of the patient.
authors.affiliation: Department of Vascular Surgery, Vrije Universiteit Hospital, Amsterdam, The Netherlands.
authors.forename: A C
authors.initials: AC
authors.lastname: Vahl
authors.forename: A J
authors.initials: AJ
authors.lastname: Mackaay
authors.forename: P C
authors.initials: PC
authors.lastname: Huijgens
authors.forename: G J
authors.initials: GJ
authors.lastname: Scheffer
authors.forename: J A
authors.initials: JA
authors.lastname: Rauwerda
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D017544:Aortic Aneurysm, Abdominal / Q000097:blood / Q000601:surgery*; D005340:Fibrinogen / Q000032:analysis; D006438:Hemodilution; D006488:Hemostasis, Surgical / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D010958:Plasminogen / Q000032:analysis; D011446:Prospective Studies; D011516:Prothrombin / Q000032:analysis; D011517:Prothrombin Time; D016896:Treatment Outcome
chemical_list: D011516:Prothrombin; D005340:Fibrinogen; D010958:Plasminogen