Allogeneic vascularized grafting of a human knee joint with postoperative immunosuppression.
In this paper we report the first successful allogeneic vascularized transplantation of a fresh and perfused human knee joint. A 17-year-old male had lost his knee in a motorvehicle accident. The graft was harvested from a multiorgan donor, perfused with 41 UW solution and transplanted within 21 h. Osteosyntheses were performed employing intramedullary nails. Immunosuppression was based mainly on two drugs: cyclosporin A and azathioprine. Five months after the operation the patient is fully mobilized, and the graft perfusion still intact. Osteotomies of the femur and tibia demonstrate callus formation and osseous consolidation.
Hofmann
G O
GO
Berufsgenossenschaftliche Unfallklinik Murnau, Germany.
Kirschner
M H
MH
Wagner
F D
FD
Land
W
W
Bühren
V
V
D000063:Accidents, Traffic; D000293:Adolescent; D000792:Angiography; D001379:Azathioprine / Q000008:administration & dosage; D016572:Cyclosporine / Q000008:administration & dosage; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007718:Knee Injuries / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D007719:Knee Joint / Q000098:blood supply / Q000601:surgery*; D008297:Male; D009104:Multiple Trauma / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery; D011182:Postoperative Care; D016059:Range of Motion, Articular; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D001379:Azathioprine