title: Cytotoxicity and electron microscopy of cell death induced by goniothalamin.
abstract: The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HGC-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells. Drug exposure studies indicated that the cytotoxic action of goniothalamin was time- and dose-dependent. At the ultrastructural level, goniothalamin-induced cytotoxicity revealed a necrotic mode of cell death towards MCF-7 cells.
authors.affiliation: Department of Biotechnology, Faculty of Food Science and Biotechnology, Universiti Pertanian Malaysia, Selangor, Malaysia.
authors.forename: A M
authors.initials: AM
authors.lastname: Ali
authors.forename: M M
authors.initials: MM
authors.lastname: Mackeen
authors.forename: M
authors.initials: M
authors.lastname: Hamid
authors.forename: Q B
authors.initials: QB
authors.lastname: Aun
authors.forename: Y
authors.initials: Y
authors.lastname: Zauyah
authors.forename: H L
authors.initials: HL
authors.lastname: Azimahtol
authors.forename: K
authors.initials: K
authors.lastname: Kawazu
mesh_terms: D016475:3T3 Cells; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects*; D006801:Humans; D051379:Mice; D008854:Microscopy, Electron; D011753:Pyrones / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D011753:Pyrones; C103280:goniothalamin