title: Allithiamine ingestion does not enhance isokinetic parameters of muscle performance.
abstract: The purpose of this study was to investigate the effect of oral allithiamine administration on isokinetic parameters of muscle performance and lactate accumulation prior to, during and in recovery from isokinetic exercise. A double-blind, counterbalanced, crossover experimental design utilizing a Biodex System 2 Isokinetic Dynamometer was used to test 15 healthy college students. Subjects orally ingested either 1 g. day-1 of a thiamin derivative, allithiamine, or placebo for 5 days and then performed six exercise sets of knee extension and flexion. ANOVA revealed no significant differences between treatment conditions in peak torque, mean peak torque, average power, or total work performed (p > .05). Likewise, lactate accumulation was not significantly different between treatment conditions at any measurement point (p > .05). The absence of significant differences suggests that oral allithiamine administration does not enhance isokinetic parameters of muscle performance or lactate accumulation prior to, during, and following isokinetic exercise.
authors.affiliation: Department of Physical Education, Western Illinois University, Macomb 61455, USA.
authors.forename: M R
authors.initials: MR
authors.lastname: Doyle
authors.forename: M J
authors.initials: MJ
authors.lastname: Webster
authors.forename: L D
authors.initials: LD
authors.lastname: Erdmann
mesh_terms: D000328:Adult; D018592:Cross-Over Studies; D004311:Double-Blind Method; D015444:Exercise; D005260:Female; D006801:Humans; D007773:Lactates / Q000097:blood; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D018482:Muscle, Skeletal / Q000187:drug effects*; D013831:Thiamine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D007773:Lactates; C012710:allithiamine; D013831:Thiamine