Lack of effect of hepatocyte growth factor on bone marrow suppression induced by total body irradiation in the rat.
We examined the role of hepatocyte growth factor (HGF) on the bone marrow suppression by irradiation, by analyzing peripheral blood counts 2 weeks after 7 Gy of total body irradiation in rats. The rats underwent two weeks of continuous intraperitoneal human recombinant HGF injection (50 mg/day) from one day before irradiation using an Alzet osmotic pump. Red blood cell, white blood cell, and platelet counts did not increase with response to administration of HGF. Thus HGF does not show protection against myelosuppression caused by total body irradiation.
Yamazaki
H
H
Department of Radiation Oncology, Osaka University Medical School, Japan.
Inoue
T
T
Tang
J T
JT
Nose
T
T
Koizumi
M
M
Tanaka
E
E
Teshima
T
T
Ozeki
S
S
Nakamura
H
H
Inoue
T
T
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects*; D017228:Hepatocyte Growth Factor / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000494:pharmacology; D014916:Whole-Body Irradiation
D011994:Recombinant Proteins; D017228:Hepatocyte Growth Factor