Social stress, depression, and brain dopamine in female cynomolgus monkeys.
Socially subordinate adult female cynomolgus monkeys are hypercortisolemic, the targets of aggression, fearful, vigilant, receive little positive affiliative contact, exhibit pathological behaviors indicating anxiety, and are disengaged in the social events around them. Subordinates also have altered dopaminergic activity that may be due to decreased D2 receptor binding. Dopaminergic activity indices were more closely associated with affiliative than agonistic behaviors.
Shively
C A
CA
Department of Comparative Medicine, Physiology & Pharmacology, and Radiology, Bowman Gray School of Medicine, Winston-Salem, North Carolina 27157, USA.
Grant
K A
KA
Ehrenkaufer
R L
RL
Mach
R H
RH
Nader
M A
MA
D000374:Aggression; D000818:Animals; D001007:Anxiety; D001921:Brain / Q000378:metabolism*; D003863:Depression / Q000503:physiopathology* / Q000523:psychology; D004291:Dominance-Subordination; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D006120:Grooming; D008252:Macaca fascicularis / Q000502:physiology / Q000523:psychology; D017448:Receptors, Dopamine D2 / Q000032:analysis / Q000502:physiology*; D012919:Social Behavior; D013315:Stress, Psychological; D014055:Tomography, Emission-Computed
D017448:Receptors, Dopamine D2; D004298:Dopamine