title: The effect of tramadol on dento-alveolar surgical pain.
abstract: The aim of the study was to assess the analgesic effect of tramadol in the relief of pain after dentoalveolar operations that involve the removal of bone and suturing. Four-hundred and fifty-two patients over the age of 18 years who were to undergo removal of impacted teeth (n = 362), removal of root (n = 79), or alveolectomy, enucleation of cysts, or removal of soft tissue (n = 11) under local anesthesia were studied. Patients were randomly allocated to receive tramadol 100 mg or 50 mg four times daily, or 50 mg twice daily, or placebo. Median pain scores on the day of operation in the three tramadol groups were similar (2 in each group, ranges 1-5, 1-4.8, and 1-5 respectively) and were all significantly lower than that in the placebo group (2.3 range 1-4.2). The median number of Paracetamol tablets taken by patients in the three tramadol groups was 2 (ranges 0-8, 0-12 and 0-8 respectively), and were all significantly less than in the placebo group (4, range 0-12). More patients given tramadol reported complete pain relief than the placebo group. The advantages of tramadol continued over the next 2 days. There were no serious or unexpected adverse effects. It is concluded that tramadol is an effective analgesic after dentoalveolar operations.
authors.affiliation: Joint Department of Oral and Maxillofacial Surgery, Eastman Dental and University College Hospitals London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Collins
authors.forename: I
authors.initials: I
authors.lastname: Young
authors.forename: P
authors.initials: P
authors.lastname: Sweeney
authors.forename: G C
authors.initials: GC
authors.lastname: Fenn
authors.forename: M E
authors.initials: ME
authors.lastname: Stratford
authors.forename: A
authors.initials: A
authors.lastname: Wilson
authors.forename: M
authors.initials: M
authors.lastname: Harris
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000541:Alveolectomy / Q000009:adverse effects; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000627:therapeutic use; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000766:Anesthesia, Dental; D000772:Anesthesia, Local; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000601:surgery; D009807:Odontogenic Cysts / Q000601:surgery; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D010919:Placebos; D013536:Suture Techniques / Q000009:adverse effects; D013607:Tablets; D014076:Tooth Diseases / Q000601:surgery*; D014092:Tooth Root / Q000601:surgery; D014095:Tooth, Impacted / Q000601:surgery; D014147:Tramadol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D010919:Placebos; D013607:Tablets; D000082:Acetaminophen; D014147:Tramadol