title: Peptic activity and gastroduodenal mucosal damage.
abstract: This contribution reviews briefly the history of the discovery and characterization of peptic activity; secretory models and current concepts regarding the regulation of pepsinogen secretion; and evidence that pepsin is a necessary co-factor for gastroduodenal mucosal injury. Several animal studies indicate that peptic activity is required for acid- and nonsteroidal anti-inflammatory drug-induced gastroduodenal ulceration. A more vigorous approach to the development of anti-peptic drugs for the treatment of peptic ulcer disease is encouraged.
authors.affiliation: Division of Gastroenterology, University of Arkansas for Medical Sciences, Little Rock 72205-7199, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Raufman
mesh_terms: D000818:Animals; D004386:Duodenum / Q000187:drug effects* / Q000473:pathology*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology*; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology*; D010434:Pepsin A / Q000009:adverse effects*
chemical_list: D010434:Pepsin A