Peroxidative damage in sickle-cell erythrocyte ghosts: protective effect of allopurinol.
1. Malondialdehyde (MDA) levels of erythrocyte membranes of sickle-cell disease patients were measured as an indicator of peroxidative damage and allopurinol was used as a lipid peroxide scavenger. 2. Incubating sickle-cell erythrocytes with allopurinol significantly reduced MDA levels of erythrocyte membranes compared with before-treatment values. 3. Allopurinol seems to reduce the peroxidative damage in sickle-cell erythrocytes, but the mechanism is still unknown.
Sertac
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A
Department of Biochemistry, Ministry of Health, Ankara Training Hospital, Cebeci, Turkey.
Bingol
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F
Aydin
S
S
Uslu
A
A
D000328:Adult; D000493:Allopurinol / Q000494:pharmacology*; D000755:Anemia, Sickle Cell / Q000097:blood*; D000975:Antioxidants / Q000494:pharmacology*; D001772:Blood Cell Count; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis
D000975:Antioxidants; D008315:Malondialdehyde; D000493:Allopurinol