title: [Sepsis related to a permanent central venous catheter in children with neoplastic disease: practical implications of a continuous surveillance of the etiology].
abstract: Indwelling central venous catheter-related bacteremias are an important complication in patients with cancer. In general they are due to Staphylococcus aureus and Candida, while bacteremias caused by Gram-negatives are less common and often related to infusate contaminans. We describe a survey of etiological surveillance of Broviac catheter-related infections at G. Gaslini Children's Hospital of Genoa, Italy. In the period 1989-1992 an increase of Broviac catheter-related bacteremias due to Gram-negatives was demonstrated as compared with previous years (1985-1988). At home parental management was suspected as an important risk factor, since this complication was frequently due to infusate contaminants and no epidemic cluster or positive surveillance culture was observed in the Hospital. Therefore at home management was changed, especially regarding heparin storage. The subsequent, prospective follow-up from July 1993 to December 1995 showed a significant decrease in catheter-related bacteremias due to Gram-negatives (P = 0.003, chi-square test). In conclusion, a strict control on at home catheter management procedures must be maintained in order to reduce the risk of indwelling central venous catheter-related infections in children with cancer.
authors.affiliation: Divisione di Malattie Infettive, Istituto "G. Gaslini" di Genova, Italia.
authors.forename: E
authors.initials: E
authors.lastname: Castagnola
authors.forename: A
authors.initials: A
authors.lastname: Garaventa
authors.forename: E
authors.initials: E
authors.lastname: Montinaro
authors.forename: P
authors.initials: P
authors.lastname: Sarni
authors.forename: L
authors.initials: L
authors.lastname: Manfredini
authors.forename: A
authors.initials: A
authors.lastname: Calvi
authors.forename: M
authors.initials: M
authors.lastname: Conte
authors.forename: C
authors.initials: C
authors.lastname: Milanaccio
authors.forename: P
authors.initials: P
authors.lastname: Venzano
authors.forename: C
authors.initials: C
authors.lastname: Micalizzi
authors.forename: E
authors.initials: E
authors.lastname: Lanino
authors.forename: L
authors.initials: L
authors.lastname: Tasso
authors.forename: R
authors.initials: R
authors.lastname: Giacchino
authors.forename: C
authors.initials: C
authors.lastname: Viscoli
authors.forename: L
authors.initials: L
authors.lastname: Massimo
mesh_terms: D016470:Bacteremia / Q000382:microbiology*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002408:Catheters, Indwelling / Q000009:adverse effects*; D002648:Child; D006801:Humans; D011446:Prospective Studies; D012189:Retrospective Studies
vernacular_title: Sepsi correlate a catetere venoso centrale a permanenza in bambini affetti da malattia neoplastica: implicazioni pratiche di una sorveglianza continua dell'eziologia.