title: p53 immunostaining in differential diagnosis of pleural mesothelial proliferations.
abstract: We evaluated tissues for the overexpression of p53 protein in 35 malignant mesotheliomas and 20 reactive pleural hyperplasias, obtained from open biopsies or pleurectomies. Of the 35 neoplasms investigated, 30 (85.7%) displayed positive nuclear staining for p53. No staining was seen in any specimens of hyperplasia. We found no significant statistical difference in p53 expression when we compared p53 overexpression in the different histological subtypes of mesotheliomas. Moreover, p53 overexpression did not correlate in a statistical manner with survival. We conclude that p53 overexpression is a frequent feature of pleural mesothelioma and is useful for routine differentiating between malignant and non-neoplastic mesothelial alterations. The reason for p53 overexpression in mesothelioma, however, remains to be determined.
authors.affiliation: Department of Pathology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia PA 19107, USA.
authors.forename: V
authors.initials: V
authors.lastname: Esposito
authors.forename: A
authors.initials: A
authors.lastname: Baldi
authors.forename: A
authors.initials: A
authors.lastname: De Luca
authors.forename: P P
authors.initials: PP
authors.lastname: Claudio
authors.forename: G
authors.initials: G
authors.lastname: Signoriello
authors.forename: A
authors.initials: A
authors.lastname: Bolognese
authors.forename: P
authors.initials: P
authors.lastname: Centonze
authors.forename: G G
authors.initials: GG
authors.lastname: Giordano
authors.forename: M
authors.initials: M
authors.lastname: Caputi
authors.forename: F
authors.initials: F
authors.lastname: Baldi
authors.forename: A
authors.initials: A
authors.lastname: Giordano
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D003937:Diagnosis, Differential; D006801:Humans; D008654:Mesothelioma / Q000737:chemistry*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D010997:Pleural Neoplasms / Q000737:chemistry*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D016159:Tumor Suppressor Protein p53