title: Antimutagenicity of phenothiazine-metal co-ordination complexes in chemically induced mutagenesis.
abstract: Phenothiazines are heterocyclic organic compounds in which nitrogen and sulfur are incorporated in the tricyclic system, and are known to have antimutagenic activity by shielding DNA-base pairs. Inorganic metals have also been intensively studied for DNA-adduct formation as potential anticancer agents. Phenothiazine, promethazine, promazine and chlorpromazine were complexed either with copper, palladium or gold. The antimutagenicity of twelve phenothiazine-metal complexes, four phenothiazines and three inorganic metals was examined on Salmonella typhimurium TA98 strain treated with a strain-specific, direct-acting mutagen, 4-nitro-o-phenylene-diamine, and the ligand-DNA interaction was analyzed by ultraviolet (UV) spectrophotometry. Phenothiazine-metal co-ordination complexes generally increased their antimutagenic activity, compared to their parent compounds, and the enhanced antimutagenicity was attributed to their interaction with DNA as evidenced by the UV spectra.
authors.affiliation: Faculty of Medicine, Institute of Microbiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: J
authors.initials: J
authors.lastname: Molnár
authors.forename: S
authors.initials: S
authors.lastname: Kidd
mesh_terms: D016588:Anticarcinogenic Agents / Q000494:pharmacology; D016587:Antimutagenic Agents / Q000494:pharmacology*; D008670:Metals / Q000494:pharmacology*; D010640:Phenothiazines / Q000494:pharmacology*
chemical_list: D016588:Anticarcinogenic Agents; D016587:Antimutagenic Agents; D008670:Metals; D010640:Phenothiazines