A new family of G-protein regulators - the RGS proteins.
Genetic experiments have recently been used to identify a family of 'regulator of G-protein signaling' (RGS) proteins, which downregulate signaling by heterotrimeric G proteins. The first biochemical studies of RGS proteins have shown that they accelerate the GTPase activities of G-protein alpha subunits, thus driving G proteins into their inactive GDP-bound forms. The physiological significance of the large number of different RGS proteins remains to be explored.
Koelle
M R
MR
Department of Molecular Biophysics and Biochemistry, Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Avenue, PO Box 9812, New Haven, CT 06536, USA. Michael.Koelle@Yale.edu
D000818:Animals; D004789:Enzyme Activation; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction
D011506:Proteins; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins