title: Interferon-alpha 2b treatment in hepatitis B carriers. Effect on hepatitis B virus DNA levels in children infected with different genotypes.
abstract: Eleven hepatitis B virus (HBV) carrier children, infected with genotypes A-D, were treated with interferon-alpha. Two children had a sustained loss of hepatitis B e-antigen and HBV DNA. They were infected with the non-Asian genotypes A and D, and had low HBV DNA and high ALT levels in serum before treatment. However, HBV DNA titres decreased during treatment also in children infected with the East-Asian genotypes B and C.
authors.affiliation: Department of Medicine, University Hospital, Uppsala, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Sangfelt
authors.forename: H
authors.initials: H
authors.lastname: Norder
authors.forename: L O
authors.initials: LO
authors.lastname: Magnius
authors.forename: A
authors.initials: A
authors.lastname: Alaeus
authors.forename: T
authors.initials: T
authors.lastname: Carlsson
authors.forename: O
authors.initials: O
authors.lastname: Reichard
mesh_terms: D000293:Adolescent; D002353:Carrier State / Q000097:blood* / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000097:blood*; D005260:Female; D005838:Genotype; D006509:Hepatitis B / Q000097:blood* / Q000628:therapy*; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D011994:Recombinant Proteins
chemical_list: D004279:DNA, Viral; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins