Computation of multilocus prior probability of autozygosity for complex inbred pedigrees.
Homozygosity mapping is a very powerful method for mapping rare recessive diseases in humans. In many applications, it is often desirable to compute prior (or unconditional) multilocus probability of autozygosity for inbred pedigrees. This paper proposes a simple yet powerful method for computing the prior multilocus autozygosity probability for complex inbred pedigrees. The method has an added feature of providing explicit multilocus autozygosity probability in terms of recombination fractions, if desired. An example is presented to illustrate the method.
Guo
S W
SW
Department of Biostatistics, University of Michigan, Ann Arbor 48109-2029, USA.
D002874:Chromosome Mapping; D003241:Consanguinity; D005718:Gametogenesis / Q000235:genetics; D005808:Genes, Recessive; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008390:Markov Chains; D010375:Pedigree; D011336:Probability