[The interaction of clofelin and ketamine in the body of patients].
Overall thirty-three patients (two groups) I-III ASA operated on with no premedication were examined. In group K an effective dose of ketamine (EDK) was determined, inducing unconsciousness during the intravenous administration with the aid of a dose-metering device. Because of an inadequate sedative effect, determining the effective dose of clonidine in the same way was found to be impossible without exceeding too much the permissible dose. 30 minutes after intravenous administration of a standard dose of clonidine (SDCl) we started infusing ketamine in group "KCl" as we did in group K. ED of ketamine was determined once again against the background of the action of clonidine (EDKCl). Deriving proportions by known EDK, EDKCl, and SDCl, a "mythical" dose EDCl was calculated. According to the published literature man loses consciousness with the dose exceeding the estimated EDCl 33.8-67.5-fold.


CONCLUSIONS
interaction of clonidine and ketamine in the organism of patients is synergic by nature.
Byshovets
S N
SN
D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D000778:Anesthetics, Dissociative / Q000008:administration & dosage / Q000494:pharmacology*; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007649:Ketamine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D013514:Surgical Procedures, Operative; D013997:Time Factors
D000316:Adrenergic alpha-Agonists; D000778:Anesthetics, Dissociative; D007649:Ketamine; D003000:Clonidine
Vzaimodeĭstvie klofelina i ketamina v organizme bol'nykh.