Enantioselective behaviour of drugs used in domestic animals: a review.
The chirality of drugs, with particular reference to agents used in veterinary medicine, is reviewed. Basic concepts of chirality and aspects of the methodology for the separation of enantiomers are considered. Chiral compounds are in common use in animals and their pharmacological actions and side-effects (pharmacodynamics) and absorption into and fate within the body (pharmacokinetics) are of fundamental importance; pharmacodynamic and pharmacokinetic properties of enantiomeric pairs commonly differ and this has major implications for their effective and safe therapeutic use. As examples of the particular significance of chirality in veterinary medicine, the following drug classes are reviewed; benzimidazole anthelmintics, cloprostenol, verapamil, ketamine, halogenated hydrocarbon anaesthetics and 2-arylpropionic acid anti-inflammatory drugs. The implications of chirality for drug product development and approval by registration authorities are discussed.
Landoni
M F
MF
Catedra de Farmacologia, Facultad de Ciencias Veterinarias, Universidad Nacional de la Plata, Argentina.
Soraci
A L
AL
Delatour
P
P
Lees
P
P
D000777:Anesthetics / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D000829:Animals, Domestic / Q000502:physiology*; D000871:Anthelmintics / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D003008:Cloprostenol / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D015195:Drug Design; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D009626:Terminology as Topic; D014665:Vasodilator Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D014700:Verapamil / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D019155:Veterinary Drugs / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology
D000777:Anesthetics; D000871:Anthelmintics; D000893:Anti-Inflammatory Agents; D014665:Vasodilator Agents; D019155:Veterinary Drugs; D003008:Cloprostenol; D014700:Verapamil