title: Juvenile glaucoma linked to the GLC1A gene on chromosome 1q in a Panamanian family.
abstract: OBJECTIVE
  To characterize clinically and genetically autosomal dominant juvenile-onset primary open-angle glaucoma in a Panamanian family.
  
  
  METHODS
  Twenty members of a six-generation family underwent ophthalmologic examination and genetic screening with markers near the GLC1A gene on chromosome 1q.
  
  
  RESULTS
  Linkage analysis disclosed evidence linking primary open-angle glaucoma in this family to the GLC1A gene on chromosome 1q, with a maximum lod score of 3.75 for marker D1S431 at an estimated recombination fraction of 0.00.
  
  
  CONCLUSIONS
  This is the first report of a Panamanian family in which primary open-angle glaucoma is linked to the GLC1A gene on chromosome 1q.
authors.affiliation: Department of Ophthalmology, University of Michigan, Ann Arbor 48105, USA.
authors.forename: P R
authors.initials: PR
authors.lastname: Lichter
authors.forename: J E
authors.initials: JE
authors.lastname: Richards
authors.forename: M
authors.initials: M
authors.lastname: Boehnke
authors.forename: M
authors.initials: M
authors.lastname: Othman
authors.forename: B D
authors.initials: BD
authors.lastname: Cameron
authors.forename: H M
authors.initials: HM
authors.lastname: Stringham
authors.forename: C A
authors.initials: CA
authors.lastname: Downs
authors.forename: S B
authors.initials: SB
authors.lastname: Lewis
authors.forename: B F
authors.initials: BF
authors.lastname: Boyd
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005902:Glaucoma, Open-Angle / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007429:Intraocular Pressure; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D010176:Panama; D010375:Pedigree; D014792:Visual Acuity
chemical_list: D005819:Genetic Markers