title: Growth dynamics of the cricoid cartilage and subglottic injury. An autoradiographic and histometric study in the rabbit.
abstract: Earlier studies in young growing rabbits have suggested that post-traumatic developmental deformities of the cricoid might play a role in failing treatment in children with similar injuries. Specific patterns of malformations in the animals occurred preferentially at the anterior side of the cricoid ring. In this study, the growth dynamics of the cricoid were studied by histometry and autoradiography. Results indicated that (1) the cell/matrix ratio remains unchanged from 4 to 24 weeks of age, with both tissue components thus contributing equally to growth of the cricoid; (2) mitoses occur in cartilage and perichondrium, indicating interstitial as well as appositional growth; (3) mitotic activity is mainly restricted to the first 4 weeks of life, while cell hypertrophy is thereafter the dominant feature; (4) the highest degree of mitotic activity and cell hypertrophy is found in the anterior half of the cricoid ring which therefore can be considered as a growth center. This center might play a role in the development of trauma-induced deformation in the anterior part of the cricoid ring.
authors.affiliation: Erasmus University Medical Center Rotterdam (EMCR), The Netherlands.
authors.forename: H L
authors.initials: HL
authors.lastname: Verwoerd-Verhoef
authors.forename: F C
authors.initials: FC
authors.lastname: Adriaansen
authors.forename: R J
authors.initials: RJ
authors.lastname: Laeijendecker
authors.forename: G J
authors.initials: GJ
authors.lastname: van Osch
authors.forename: C D
authors.initials: CD
authors.lastname: Verwoerd
mesh_terms: D000375:Aging / Q000473:pathology; D000818:Animals; D001345:Autoradiography; D002452:Cell Count; D003413:Cricoid Cartilage / Q000254:growth & development* / Q000293:injuries / Q000473:pathology; D003584:Cytological Techniques; D005109:Extracellular Matrix / Q000473:pathology; D005260:Female; D005931:Glottis / Q000254:growth & development / Q000293:injuries / Q000473:pathology; D006984:Hypertrophy; D008938:Mitosis; D011817:Rabbits; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
chemical_list: D014316:Tritium; D013936:Thymidine