The JAK-STAT pathway in Drosophila.
Recent studies in Drosophila have identified a single JAK and a single STAT protein. Genetic and biochemical analyses reveal that these two proteins operate in the same signal transduction pathway. Phenotypic analyses of JAK and STAT mutants implicate this pathway in a number of developmental decisions, in particular the regulation of pair-rule genes and fly hematopoiesis.
Hou
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XS
Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. hou@rascal.med.harvard.edu
Perrimon
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N
D000818:Animals; D002455:Cell Division / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism*; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D029721:Drosophila Proteins; D004625:Embryo, Nonmammalian; D005260:Female; D018507:Gene Expression Regulation, Developmental; D053612:Janus Kinases; D007814:Larva; D008894:Milk Proteins; D009369:Neoplasms / Q000235:genetics; D011505:Protein-Tyrosine Kinases / Q000235:genetics* / Q000378:metabolism*; D050791:STAT Transcription Factors; D050799:STAT5 Transcription Factor; D015398:Signal Transduction; D015534:Trans-Activators / Q000235:genetics* / Q000378:metabolism*; D014157:Transcription Factors
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D008894:Milk Proteins; D050791:STAT Transcription Factors; D050799:STAT5 Transcription Factor; C105675:Stat92E protein, Drosophila; D015534:Trans-Activators; D014157:Transcription Factors; D011505:Protein-Tyrosine Kinases; D053612:Janus Kinases; C085845:hop protein, Drosophila