[Synthesis and expression of transforming growth factor-beta in activated macrophages].
It has been established that once macrophages become activated, they pass through different stages of functional activity. Mouse macrophages activated by BCG "exerted" pronounced cytotoxic effects for 2-5 days to be followed later by growth-stimulating ones. However, in other experiments, the cytotoxic effect was either absent or occurred at later stages which was probably due to a certain functional state of macrophages before activation. The synthesis of TGF-beta increased 1-2 days after activation with BCG vaccine, lipopolysacharide and gamma radiation. An increase in mRNA TGF-beta i expression was observed only 5 days after activation of macrophages.
Zubova
S G
SG
Danilov
A O
AO
Okulov
V B
VB
Kiagulov
D F
DF
Stiuf
I I
II
Zaritskiĭ
A I
AI
D000818:Animals; D005720:Gamma Rays; D008070:Lipopolysaccharides; D008262:Macrophage Activation; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D009163:Mycobacterium bovis; D016212:Transforming Growth Factor beta / Q000096:biosynthesis*
D008070:Lipopolysaccharides; D016212:Transforming Growth Factor beta
Sintez i èkspressiia transformiruiushchego faktora rosta-beta aktivirovannymi makrofagami.