Immunodepression induced by carbamazepine administration is mediated by CD 8+ spleen T cells.
The values observed in this series of experiments showed that CD 8+ spleen T cells obtained from 15-mg/kg carbamazepine (CBZ)-treated donor mice were capable of diminishing both humoral and cellular immune responses of normal spleen cells when transferred into lethally irradiated recipient animals. Immune responses were evaluated by enumeration of direct and indirect plaque-forming spleen cells (PFC) and by the delayed-type hypersensitivity reaction (DTH) to sheep red blood cells.
Andrade-Mena
C E
CE
Department of Scientific Investigation, University Centre of Health Sciences, University of Guadalajara, México.
D000818:Animals; D000917:Antibody Formation; D000927:Anticonvulsants / Q000494:pharmacology*; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D002220:Carbamazepine / Q000494:pharmacology*; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012756:Sheep; D013154:Spleen / Q000166:cytology
D000927:Anticonvulsants; D007166:Immunosuppressive Agents; D002220:Carbamazepine