title: Asymptomatic primary Sjögren's syndrome in a patient with penicillin drug eruption.
abstract: A 20-year-old woman visited our clinic because of acral numbness and skin eruptions after administration of oral penicillin. Serological tests revealed an increase of immunoglobulins (G & M), positive rheumatoid factor, anti-nuclear factor, anti-SSA and -SSB antibodies. Ophthalmologic and otolaryngological studies were consistent with those of Sjögren's syndrome. However, a skin biopsy specimen failed to show any specific changes for Sjögren's syndrome and the diagnosis of penicillin drug eruption was considered to be more preferable. We briefly discussed the coexistence of a drug allergy and asymptomatic connective tissue disease.
authors.affiliation: Division of Dermatology, Sapporo-Kosei General Hospital, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D003875:Drug Eruptions / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D010406:Penicillins / Q000008:administration & dosage / Q000009:adverse effects*; D012217:Rheumatoid Factor / Q000032:analysis; D012678:Sensation Disorders / Q000139:chemically induced; D012859:Sjogren's Syndrome / Q000150:complications* / Q000473:pathology; D012867:Skin / Q000473:pathology
chemical_list: D000974:Antibodies, Antinuclear; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010406:Penicillins; C035356:SS-A antibodies; C035357:SS-B antibodies; D012217:Rheumatoid Factor