Ultrastructural studies on organs of cadmium-poisoned rats treated with oxygen-ozone mixture.
Rats poisoned with cadmium acetate during 12 weeks, at a dose of 50 mg/dm3 given in drinking water, were treated with oxygen-ozone mixture as intraperitoneal injection during the last 10 days of the experiment, at a daily dose of 1 cm3 and ozone concentration 40 micrograms/cm3. The mixture was made of medical oxygen with a Bioozon U type apparatus produced by B. Prochazka GmbH, Germany, Reutlingen. Control groups included animals treated with the above mixture with no cadmium, and rats poisoned with cadmium, with no oxygen-ozone treatment. Liver and cardiac muscle were examined in TEM Philips EM 301. Morphological traits of a protective of the mixture against cadmium-poisoning were observed in both those organs. This was expressed as weaker destructive changes within the endoplasmic reticulum, basal cytoplasm and lysosome of the hepatocytes, and additionally as a stabilization of contractile apparatus fibres in the heart myocytes.
Kuryszko
J
J
Department of Histology and Embroylogy, Agricultural University, Wrocław, Poland.
Madej
J A
JA
Madej
P
P
D000284:Administration, Oral; D000818:Animals; D000931:Antidotes / Q000008:administration & dosage / Q000627:therapeutic use*; D002104:Cadmium / Q000008:administration & dosage; D002105:Cadmium Poisoning / Q000188:drug therapy*; D003593:Cytoplasm / Q000187:drug effects / Q000648:ultrastructure; D004326:Drinking; D004359:Drug Therapy, Combination; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000648:ultrastructure; D005260:Female; D006321:Heart / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008247:Lysosomes / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D009206:Myocardium / Q000473:pathology / Q000648:ultrastructure; D010100:Oxygen / Q000008:administration & dosage / Q000627:therapeutic use*; D010126:Ozone / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D000931:Antidotes; D002104:Cadmium; D010126:Ozone; D010100:Oxygen