title: Photorepair of ultraviolet radiation (UVR)-induced pyrimidine dimers in lens epithelial DNA of Monodelphis domestica.
abstract: The repair of UV radiation-induced pyrimidine dimers has been measured in lens epithelial DNA of the marsupial Monodelphis domestica using a pyrimidine dimer-specific endonuclease from Micrococcus luteus. Approximately 40% of the initially induced dimers were repaired during 90 min exposures to photoreactivating light. This capacity of the lens epithelium to photorepair pyrimidine dimers may provide a means with which to determine whether pyrimidine dimers in lens epithelial DNA are involved in UV radiation-induced pathologic changes of the lens.
authors.affiliation: Photomedicine Program, Institute for Basic and Applied Medical Research, Lovelace Institutes, Albuquerque, NM 87108, USA.
authors.forename: G B
authors.initials: GB
authors.lastname: Tafoya
authors.forename: J M
authors.initials: JM
authors.lastname: Gale
authors.forename: R D
authors.initials: RD
authors.lastname: Ley
mesh_terms: D000818:Animals; D004260:DNA Repair / Q000528:radiation effects; D007908:Lens, Crystalline / Q000378:metabolism / Q000528:radiation effects*; D009893:Opossums; D010777:Photochemistry; D011740:Pyrimidine Dimers / Q000378:metabolism*; D014466:Ultraviolet Rays
chemical_list: D011740:Pyrimidine Dimers