title: Increased apolipoprotein E epsilon 4 in epilepsy with senile plaques.
abstract: Inheritance of the apolipoprotein E (ApoE) epsilon 4 allele is a risk factor for Alzheimer's disease (AD) and is associated with increased deposition of beta-amyloid (A beta) in AD, Down's syndrome, and normal aging. A beta deposition in the form of senile plaques (SPs) has recently been described in patients with temporal lobe epilepsy (TLE). We studied the relationship between ApoE epsilon 4 genotype and the deposition of A beta in temporal lobe tissue from patients who underwent temporal lobectomy for intractable epilepsy. TLE patients with SPs had a 70% ApoE epsilon 4 carrier frequency compared with a 27% carrier frequency among age-matched TLE controls without SPs. Our data suggest that the association between ApoE epsilon 4 and intracerebral A beta accumulation is not unique to the elderly or to those with dementia, and may be a feature of conditions in which there is both an ApoE epsilon 4 allele and over-production of A beta precursor protein, and, presumably, A beta.
authors.affiliation: Department of Neurology and Neuroscience, Cornell University Medical College, New York, NY 10021, USA. gkgouras@mail.med.cornell.edu
authors.forename: G K
authors.initials: GK
authors.lastname: Gouras
authors.forename: N R
authors.initials: NR
authors.lastname: Relkin
authors.forename: D
authors.initials: D
authors.lastname: Sweeney
authors.forename: D G
authors.initials: DG
authors.lastname: Munoz
authors.forename: I R
authors.initials: IR
authors.lastname: Mackenzie
authors.forename: S
authors.initials: S
authors.lastname: Gandy
mesh_terms: D016229:Amyloid beta-Peptides / Q000032:analysis; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001706:Biopsy; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004833:Epilepsy, Temporal Lobe / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D013702:Temporal Lobe / Q000737:chemistry / Q000473:pathology
chemical_list: D016229:Amyloid beta-Peptides; D053327:Apolipoprotein E4; D001057:Apolipoproteins E