Adrenomedullin: a new peptide involved in cardiorenal homeostasis?
Adrenomedullin (ADM) was originally discovered in human pheochromocytoma but is now known to be widely distributed in various organs including the kidney. ADM is a potent hypotensive peptide that increases renal blood flow and causes natriuresis and diuresis. While ADM may act in a paracrine manner, circulating levels are increased in hypertension, chronic renal failure and congestive heart failure. Current evidence suggests that ADM may play an important role in cardiorenal homeostasis.
Edwards
R M
RM
Department of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406-0939, USA.
Trizna
W
W
Aiyar
N
N
D053607:Adrenomedullin; D000595:Amino Acid Sequence; D002320:Cardiovascular Physiological Phenomena; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry / Q000502:physiology*; D012079:Renal Circulation / Q000502:physiology*; D014665:Vasodilator Agents / Q000378:metabolism*
D010455:Peptides; D014665:Vasodilator Agents; D053607:Adrenomedullin