title: Antibody to the host cellular gene-derived epitope GOR-1 in liver transplant recipients with hepatitis C virus infection.
abstract: The presence of anti-GOR was determined in paired pre-orthotopic liver transplantation (pre-OLT) and post-OLT sera from 87 OLT patients with hepatitis C virus infection. Before OLT, 48/87 patients were seropositive for anti-GOR, but this marker had no relationship with the clinical and biochemical parameters, or viremia level. Anti-GOR was less commonly detected in patients infected with genotype 3a, compared with genotypes 1 and 2, which might be related to the less conserved nature of the proposed shared epitope (amino acid sequence 9-18) in genotype 3a isolates. After OLT (median follow-up 16 months), anti-GOR was detected in 31/87 patients and it had no correlation with the clinical and biochemical parameters, viremia level, histologic disease activity, and clinical outcome. Changes in anti-GOR status (before OLT versus after OLT) were also not related to any of the clinical parameters. Although anti-GOR is commonly detected in OLT patients infected with hepatitis C virus genotypes 1 and 2, it has no clinical or prognostic significance.
authors.affiliation: Department of Medicine, University of Florida, Gainesville 32610, USA.
authors.forename: M
authors.initials: M
authors.lastname: Reiser
authors.forename: N
authors.initials: N
authors.lastname: Terrault
authors.forename: D R
authors.initials: DR
authors.lastname: Nelson
authors.forename: M
authors.initials: M
authors.lastname: Mizokami
authors.forename: L
authors.initials: L
authors.lastname: Ferrell
authors.forename: J R
authors.initials: JR
authors.lastname: Lake
authors.forename: J P
authors.initials: JP
authors.lastname: Roberts
authors.forename: N L
authors.initials: NL
authors.lastname: Ascher
authors.forename: T L
authors.initials: TL
authors.lastname: Wright
authors.forename: J Y
authors.initials: JY
authors.lastname: Lau
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D000939:Epitopes; D005260:Female; D016174:Hepacivirus / Q000145:classification; D006526:Hepatitis C / Q000276:immunology* / Q000821:virology; D018937:Hepatitis C Antibodies / Q000032:analysis; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged
chemical_list: D001323:Autoantibodies; D000939:Epitopes; D018937:Hepatitis C Antibodies