Progressive multifocal leukoencephalopathy in an HIV-infected child.
A child with perinatally acquired HIV infection presented with acute neurologic deterioration. A cerebellar white matter lesion seen on CT and MRI later proved to be progressive multifocal leukoencephalopathy (PML) by histology. Although a recognized disease of HIV-infected adults, PML is certain to be seen with more frequency in HIV-infected children who are surviving longer as a result of improved medical care. Recognition of the clinical and radiographic manifestations is important because of the dismal prognosis.
Morriss
M C
MC
Department of Radiology, The Children's Hospital of Philadelphia, PA 19104, USA.
Rutstein
R M
RM
Rudy
B
B
Desrochers
C
C
Hunter
J V
JV
Zimmerman
R A
RA
D015526:AIDS Dementia Complex / Q000175:diagnosis* / Q000473:pathology; D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000473:pathology; D001706:Biopsy; D001921:Brain / Q000473:pathology; D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009460:Neurologic Examination; D014057:Tomography, X-Ray Computed