title: Altered patterns of subchondral bone mineralization in Kienböck's disease.
abstract: The pattern of subchondral bone density, which is supposed to reflect the long-term distribution of stress, was investigated in both wrist joints of nine healthy young subjects and seven patients suffering from Kienböck's disease by means of CT osteoabsorptiometry. Two density maxima were found on the distal articular surface of the radius in the healthy subjects, corresponding to the position of the scaphoid and the lunate. Our relative quantitative results showed three different physiological types of stress indicated by the predominantly monocentric density maxima either on the scaphoid or the lunate surface of the radius and the symmetrical distribution of the mineralization. In Kienböck's disease no type of mineralization predominated. In the progressive stages the lunate density maximum was absent. The overall mineralization was generally less than in controls. Changes in the pattern of mineralization were also found on the contralateral side.
authors.affiliation: Institute of Anatomy, Ludwig-Maximilians University, Munich, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Giunta
authors.forename: N
authors.initials: N
authors.lastname: Löwer
authors.forename: K
authors.initials: K
authors.lastname: Wilhelm
authors.forename: R
authors.initials: R
authors.lastname: Keirse
authors.forename: C
authors.initials: C
authors.lastname: Rock
authors.forename: M
authors.initials: M
authors.lastname: Müller-Gerbl
mesh_terms: D000328:Adult; D015519:Bone Density / Q000502:physiology*; D002348:Carpal Bones / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D010007:Osteochondritis / Q000175:diagnosis* / Q000503:physiopathology; D010020:Osteonecrosis / Q000175:diagnosis / Q000503:physiopathology; D012016:Reference Values; D014057:Tomography, X-Ray Computed; D016474:Weight-Bearing / Q000502:physiology; D014955:Wrist Joint / Q000473:pathology