One-dimensional modelling of the vulnerability to re-entry of homogeneous atrial tissue.
A one-dimensional excitable medium model of atrial tissue derived from the Earm-Hilgemann-Noble excitation equations for atrial excitation is used to investigate (1) the rate dependence of the conduction velocity of travelling wave solutions and (2) vulnerability to unidirectional conduction block and hence re-entry. The effects of changes in the ACh activated K+ current and Na+/K+ pump inhibition on these properties are computed.
Zhang
H
H
Department of Physiology, The University, Leeds.
Holden
A V
AV
D000109:Acetylcholine / Q000502:physiology; D016275:Atrial Function; D000252:Calcium-Transporting ATPases / Q000502:physiology*; D003198:Computer Simulation; D006327:Heart Block; D006329:Heart Conduction System / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D013610:Tachycardia / Q000503:physiopathology
D000252:Calcium-Transporting ATPases; D000109:Acetylcholine