title: 7-Sulfooxymethylbenz[a]anthracene is an ultimate electrophilic and carcinogenic form of 7-hydroxymethylbenz[a]anthracene.
abstract: The hypothesis was tested that 7-sulfooxymethylbenz[a]anthracene (7-SBA) is an ultimate electrophilic and carcinogenic form of 7-hydroxymethylbenz[a]anthracene. In conformity with this hypothesis, 7-SBA was more carcinogenic than 7-HBA in inducing sarcomas at the site of repeated subcutaneous injection. These metabolites were individually administered to female Sprague-Dawley rats, beginning at 30 days of age, in 0.2 mumol doses given three times each week for 20 doses. One year after the first injection of 7-SBA, seven of thirteen female Sprague-Dawley rats had developed sarcomas. 7-HBA, on the other hand, had induced sarcomas at the site of injection in only two of tweleve rats. No tumors developed either in the control group given sesame oil:DMSO only or in the untreated control group. It would appear from the results summarized here that the search for an ultimate electrophilic and carcinogenic form of 7-HBA has been successful.
authors.affiliation: Department of Pharmacology, A.B. Chandler Medical Center, University of Kentucky, Lexington 40536-0084, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Flesher
authors.forename: J
authors.initials: J
authors.lastname: Horn
authors.forename: A F
authors.initials: AF
authors.lastname: Lehner
mesh_terms: D000818:Animals; D001551:Benz(a)Anthracenes / Q000737:chemistry* / Q000494:pharmacology; D002273:Carcinogens / Q000737:chemistry*; D005260:Female; D051381:Rats; D017207:Rats, Sprague-Dawley; D012513:Sarcoma, Experimental / Q000139:chemically induced*; D013463:Sulfuric Acid Esters / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D001551:Benz(a)Anthracenes; D002273:Carcinogens; D013463:Sulfuric Acid Esters; C025909:7-hydroxymethylbenz(a)anthracene; C105099:7-sulfooxymethylbenz(a)anthracene