title: Reduction of red-green discrimination by dopamine D1 receptor antagonists and retinal dopamine depletion.
abstract: Reduction of wavelength discrimination ability in the 560-640 nm range, but not in the 404-540 nm range, has been demonstrated in goldfish after intravitreal injection of D1-dopamine receptor antagonists. Intravitreal injection of the dopaminergic neurotoxin 6-OH-dopamine severely reduced wavelength discrimination ability in the 540-661 nm range within 3 days. Discrimination ability could be reconstituted by the D1-agonist SKF 38393. Animals recovered from injection of 6-OH-dopamine within 14-16 days. No change of wavelength discrimination was induced by 6-OH-dopamine in the 461-540 nm range. We conclude that under photopic conditions dopamine modulates retinal mechanisms involved in red-green colour coding via D1-dopamine receptor-like binding sites.
authors.affiliation: Institut für Zoologie III, Johannes Gutenberg Universität Mainz, Germany. cmora@life.bio.sunysb.edu
authors.forename: C
authors.initials: C
authors.lastname: Mora-Ferrer
authors.forename: C
authors.initials: C
authors.lastname: Neumeyer
mesh_terms: D000818:Animals; D003118:Color Perception / Q000187:drug effects* / Q000502:physiology; D004192:Discrimination, Psychological / Q000502:physiology; D004298:Dopamine / Q000502:physiology*; D018491:Dopamine Agonists / Q000494:pharmacology; D006054:Goldfish / Q000502:physiology*; D006892:Hydroxydopamines / Q000494:pharmacology; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors* / Q000502:physiology; D012160:Retina / Q000378:metabolism*
chemical_list: D018491:Dopamine Agonists; D006892:Hydroxydopamines; D017447:Receptors, Dopamine D1; D004298:Dopamine