title: Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana.
abstract: Bioassay-guided isolation procedures using human tumor cell lines led to isolation of dibromophakellstatin (4) from the Republic of Seychelles sponge Phakellia mauritiana. The isolation, X-ray crystal structure elucidation, absolute stereochemistry, and antineoplastic activity have been summarized. P. mauritiana was also found to contain dibromophakellin (1), debromohymenialosine (2), thymidine, deoxyuridine, and thymine.
authors.affiliation: Department of Chemistry, Arizona State University, Tempe 85287-2404, USA.
authors.forename: G R
authors.initials: GR
authors.lastname: Pettit
authors.forename: J
authors.initials: J
authors.lastname: McNulty
authors.forename: D L
authors.initials: DL
authors.lastname: Herald
authors.forename: D L
authors.initials: DL
authors.lastname: Doubek
authors.forename: J C
authors.initials: JC
authors.lastname: Chapuis
authors.forename: J M
authors.initials: JM
authors.lastname: Schmidt
authors.forename: L P
authors.initials: LP
authors.lastname: Tackett
authors.forename: M R
authors.initials: MR
authors.lastname: Boyd
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007093:Imidazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D007093:Imidazoles; C104805:dibromophakellstatin