Regulation of RNA polymerases I and III by the retinoblastoma protein: a mechanism for growth control?
The retinoblastoma protein, RB, is an important tumour suppressor. Recent studies have shown that it inhibits the synthesis of both rRNA and tRNA by RNA polymerases I and III. Suppression of these important determinants of biosynthetic capacity might provide a mechanism for restraining cell growth. Loss of this control could constitute one step towards tumour progression.
White
R J
RJ
Institute of Biomedical and Life Sciences, University of Glasgow, UK. rwhite@udcf.gla.ac.uk
D000818:Animals; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D002455:Cell Division / Q000502:physiology*; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D005544:Forecasting; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism; D011506:Proteins; D012318:RNA Polymerase I / Q000235:genetics* / Q000378:metabolism*; D012320:RNA Polymerase III / Q000235:genetics / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism; D016160:Retinoblastoma Protein / Q000235:genetics / Q000378:metabolism*; D056465:Retinoblastoma-Binding Protein 1; D050720:Retinoblastoma-Like Protein p107; D050717:Retinoblastoma-Like Protein p130; D050680:Transcription Factor DP1; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D009687:Nuclear Proteins; D010750:Phosphoproteins; D011506:Proteins; C493837:RBL2 protein, human; D012097:Repressor Proteins; D016160:Retinoblastoma Protein; D056465:Retinoblastoma-Binding Protein 1; D050720:Retinoblastoma-Like Protein p107; D050717:Retinoblastoma-Like Protein p130; D050680:Transcription Factor DP1; D014157:Transcription Factors; D012318:RNA Polymerase I; D012320:RNA Polymerase III