Tumor necrosis factor production and colon cancer.
Tumor necrosis factor (TNF) production in B10 mice exhibiting H-2 gene heterogeneity and in C3H/He mice differing in lipopolysaccharide (LPS) responsiveness was investigated following stimulation with OK-432. TNF-producing capacity in these mice was H-2-restricted, while their LPS responsiveness was independent of the gene. TNF production in humans was found to be HLA-B antigen-restricted. An investigation was then made of the effect of endogenous TNF induction with OK-432 on the survival rate of colorectal cancer patients. Patients in the TNF-producing group showed a trend toward having a better prognosis as compared to those in the TNF-nonproducing group. Cancer therapy formulated with consideration of host responsiveness to OK-432 may afford greater therapeutic benefit and may prolong survival.
Ito
H
H
Ito Clinic, Zama, Kanagawa.
Yagita
A
A
Fujitsuka
M
M
Atomi
Y
Y
Tatekawa
I
I
D000328:Adult; D000368:Aged; D000818:Animals; D015179:Colorectal Neoplasms / Q000097:blood / Q000378:metabolism*; D005260:Female; D015235:HLA-B Antigens / Q000032:analysis; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D015235:HLA-B Antigens; D014409:Tumor Necrosis Factor-alpha