title: Initiation of alveolar ridge augmentation in the rat mandible by subperiosteal implantation of octacalcium phosphate.
abstract: The study was designed to investigate the process of bone formation caused by implantation of octacalcium phosphate as well as stability of the bone formed at the alveolar ridge. Synthetic octacalcium phosphate was implanted into a subperiosteal pocket in the rat mandible. Bone formation at the alveolar ridge was examined radiographically and histologically between 1 and 48 week(s) after implantation. Radiopacity of the octacalcium phosphate implant became obvious in week 2. Osteogenesis was initiated from the bone surface near the implantation site and multinucleated giant cells appeared on the implanted octacalcium phosphate in week 1. More apposition of new bone was observed on the implanted octacalcium phosphate in week 2 or later. Some implants were directly enclosed by newly formed bone and no cellular component was seen between the implant and the bone matrix. Many octacalcium phosphate implants were enclosed by bone, whereas the augmented ridge was not seen radiographically in week 24 or later. If its persistence can be improved, octacalcium phosphate could be used to augment atrophic alveolar ridges.
authors.affiliation: Department of Maxillofacial Surgery I, School of Dentistry, Tohoku University, Sendai, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kamakura
authors.forename: Y
authors.initials: Y
authors.lastname: Sasano
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: O
authors.initials: O
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Ohki
authors.forename: M
authors.initials: M
authors.lastname: Kagayama
authors.forename: K
authors.initials: K
authors.lastname: Motegi
mesh_terms: D000539:Alveolar Process / Q000000981:diagnostic imaging / Q000473:pathology / Q000502:physiology; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000543:Alveoloplasty; D000818:Animals; D001284:Atrophy; D001857:Bone Matrix / Q000000981:diagnostic imaging / Q000473:pathology / Q000502:physiology; D018786:Bone Substitutes; D002130:Calcium Phosphates; D003287:Contrast Media; D015726:Giant Cells / Q000473:pathology; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging / Q000473:pathology / Q000502:physiology / Q000601:surgery*; D010012:Osteogenesis; D010521:Periosteum / Q000473:pathology / Q000502:physiology / Q000601:surgery; D019736:Prostheses and Implants; D011859:Radiography; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; D003287:Contrast Media; C022045:octacalcium phosphate