Comparative genomic hybridization study of primary neuroblastoma tumors. United Kingdom Children's Cancer Study Group.
Neuroblastoma tumors show a complex interaction of genetic abnormalities, among which some are of significant prognostic importance; however, analysis of chromosome changes in this tumor is often unsuccessful. Twenty primary tumors were studied by comparative genomic hybridization (CGH), and abnormalities were found in 19. While these changes included deletions of chromosome arm Ip (45%) and MYCN oncogene amplification (30%), gains of chromosome 17 material were much more frequent (75%). We also found evidence in two cases of a new amplification site at band 2p23.
Lastowska
M
M
Department of Human Genetics, University of Newcastle upon Tyne, UK.
Nacheva
E
E
McGuckin
A
A
Curtis
A
A
Grace
C
C
Pearson
A
A
Bown
N
N
D000293:Adolescent; D015139:Blotting, Southern; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002886:Chromosomes, Human, Pair 17; D002889:Chromosomes, Human, Pair 2; D004273:DNA, Neoplasm / Q000032:analysis; D005784:Gene Amplification; D016259:Genes, myc; D006801:Humans; D007091:Image Processing, Computer-Assisted; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D008677:Metaphase; D009447:Neuroblastoma / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D014178:Translocation, Genetic
D004273:DNA, Neoplasm