title: Molecular mechanisms underlying the actions of the pro-inflammatory cytokine interleukin 1. Royal Irish Academy Medal Lecture.
authors.affiliation: Department of Biochemistry, Trinity College Dublin, Ireland.
authors.forename: L A
authors.initials: LA
authors.lastname: O'Neill
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology*; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000494:pharmacology* / Q000502:physiology*; D008322:Mammals; D016328:NF-kappa B / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D011494:Protein Kinases; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors / Q000502:physiology; D053573:Receptors, Interleukin-1 Type I; D053574:Receptors, Interleukin-1 Type II; D015290:Second Messenger Systems; D012795:Sialoglycoproteins / Q000502:physiology; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism; D010566:Virulence Factors, Bordetella / Q000494:pharmacology
chemical_list: C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D016328:NF-kappa B; D010743:Phospholipids; D017472:Receptors, Interleukin-1; D053573:Receptors, Interleukin-1 Type I; D053574:Receptors, Interleukin-1 Type II; D012795:Sialoglycoproteins; D014157:Transcription Factors; D010566:Virulence Factors, Bordetella; D000242:Cyclic AMP; D011494:Protein Kinases; D019204:GTP-Binding Proteins