Competition between adjacent meiotic recombination hotspots in the yeast Saccharomyces cerevisiae.
In a wild-type strain of Saccharomyces cerevisiae, a hotspot for meiotic recombination is located upstream of the HIS4 gene. An insertion of a 49-bp telomeric sequence into the coding region of HIS4 strongly stimulates meiotic recombination and the local formation of meiosis-specific double-strand DNA breaks (DSBs). When strains are constructed in which both hotspots are heterozygous, hotspot activity is substantially less when the hotspots are on the same chromosome than when they are on opposite chromosomes.
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Department of Biology, University of North Carolina, Chapel Hill 27599-3280, USA.
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D000429:Alcohol Oxidoreductases; D000619:Aminohydrolases; D005656:Fungal Proteins / Q000235:genetics*; D006579:Heterozygote; D008540:Meiosis / Q000235:genetics*; D011755:Pyrophosphatases; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins; D016615:Telomere; D014157:Transcription Factors / Q000235:genetics*
D005656:Fungal Proteins; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D000429:Alcohol Oxidoreductases; C092116:HIS4 protein, S cerevisiae; D000619:Aminohydrolases; D011755:Pyrophosphatases