title: In vivo genotoxicity of selected herbicides in the mouse bone-marrow micronucleus test.
abstract: The herbicides alachlor, atrazine, terbuthylazine, gluphosinate-ammonium, isoproturon, pendimethaline and trifluralin were tested for genotoxicity in the mouse bone-marrow micronucleus test (MNT). Both atrazine and trifluraline caused a significant increase in the number of micronuclei at doses of 1,400 mg/kg body weight in female mice only. Alachlor, terbuthylazine, gluphosinate-ammonium, isoproturon and pendimethaline did not have any genotoxic effect in the mouse bone-marrow micronucleus test in either female or male animals.
authors.affiliation: Medical Institute for General Hygiene and Environmental Health, Georg-August-Universität, Göttingen, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Gebel
authors.forename: S
authors.initials: S
authors.lastname: Kevekordes
authors.forename: K
authors.initials: K
authors.lastname: Pav
authors.forename: R
authors.initials: R
authors.lastname: Edenharder
authors.forename: H
authors.initials: H
authors.lastname: Dunkelberg
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure*; D005260:Female; D006540:Herbicides / Q000633:toxicity*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*
chemical_list: D006540:Herbicides; D009153:Mutagens