title: Synthesis and antitumor activity of spin labeled derivatives of podophyllotoxin.
abstract: Three new nitroxyl labeled derivatives of podophyllotoxin 4-6 have been synthesized and evaluated for their antitumor activity in vitro. Compounds 4-6 showed significant inhibitory activity against human nasopharyngeal carcinoma KB,lung cancer A549 and stomach carcinoma SGC-7901 cells, as well as mouse leukemia L1210 and P388 cells. Compounds 4 and 5 exhibited comparable or superior activity to clinically used etoposide (VP-16,2) in their inhibition of these cell lines.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, P.R. China.
authors.forename: X
authors.initials: X
authors.lastname: Tian
authors.forename: Y G
authors.initials: YG
authors.lastname: Wang
authors.forename: M G
authors.initials: MG
authors.lastname: Yang
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Chen
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D011034:Podophyllotoxin / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013113:Spin Labels; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013113:Spin Labels; D011034:Podophyllotoxin