Gene deficiency of glutathione S-transferase mu isoform associated with susceptibility to lung cancer in a Chinese population.
Increased lung cancer risk associated with genetic polymorphism of glutathione S-transferase (GST, EC 2.5.1.18) isozyme mu was examined in a Chinese population. A significantly higher proportion in lung cancer patients showed GST mu deficiency compared with control group (71.0% vs. 51.1%, P < 0.005). Although the susceptibility to lung cancer showing gene deletion for GST mu isoform in non-smoking group is not significantly different from that in smoking group, a great number of individuals with gene deletion was found among cancer patients who are less than 50 years old. The pathology of lung tumors related to that lack of class mu isoform which occurred most frequently in patients with small cell carcinomas. Thus, present data further support that sensitivity to chemical toxins and pulmonary carcinogens may be affected by GST mu isoform polymorphism.
Sun
G F
GF
School of Preventive Medicine, China Medical University, Shenyang, China.
Shimojo
N
N
Pi
J B
JB
Lee
S
S
Kumagai
Y
Y
D000230:Adenocarcinoma / Q000235:genetics; D000367:Age Factors; D018288:Carcinoma, Small Cell / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D002681:China / Q000453:epidemiology; D005260:Female; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012907:Smoking / Q000235:genetics
D005982:Glutathione Transferase