Novel patterns of p53 abnormality in breast cancer from Taiwan: experience from a low-incidence area.
Among 114 breast cancers in Taiwan, the prevalence of p53 mutation (22.8%) and p53 accumulation (38.3%) was similar to that in high-incidence areas. However, novel patterns of p53 abnormalities, including unique sites or types of mutation (i.e. an excessive proportion of G:C to A:T transition at CpG site), and accumulation of wild-type p53 either within nuclear or cytoplasmic compartments were noted. These may have relevance to breast cancer in Taiwan, a low-incidence area.
Lou
M A
MA
Cardinal Tien Hospital, Taipei, Taiwan.
Tseng
S L
SL
Chang
S F
SF
Yue
C T
CT
Chang
B L
BL
Chou
C H
CH
Yang
S L
SL
Teh
B H
BH
Wu
C W
CW
Shen
C Y
CY
D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics*; D005091:Exons; D016158:Genes, p53; D006801:Humans; D015994:Incidence; D009154:Mutation; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D013624:Taiwan