Synthesis of N,N'-bis-aminoalkyl-substituted derivatives of bicyclo[2.2.2]oct-7-ene-2,3,5,6-tetracarboxydiimide with potential anxiolytic activity.
In continuation of the search for discovering new antipsychotic and anxiolytic agents with a reduced production of extrapyramidala side-effects, a series of N,N'-bis-aminoalkyl derivatives of bicyclo[2.2.2]oct-7-ene tetracarboxydiimide was prepared. Evaluation of these compounds in vitro revealed a very low affinity for 5-HT1A receptor.
Turło
J
J
Katedra i Zakład Chemii Medycznej, Akademia Medyczna w Warszawie, Polska (Poland).
Zawadowski
T
T
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects; D001933:Brain Stem / Q000187:drug effects / Q000378:metabolism; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D002065:Buspirone / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D051381:Rats; D011985:Receptors, Serotonin / Q000378:metabolism; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013388:Succinimides / Q000138:chemical synthesis* / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D001952:Bridged-Ring Compounds; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; D013388:Succinimides; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D002065:Buspirone