Plasma levels of protoporphyrin IX in humans after oral administration of 5-aminolevulinic acid.
We report on the pharmacokinetics of PP formation and elimination in 4 patients after the administration of oral ALA (60 mg kg-1). After a brief distribution phase, plasma PP levels decline (half life = 8 h) and was almost undetectable by 48 h post-administration. This confirms pharmacokinetic clinical data which show that ALA in a shortened interval of skin photosensitization compared with other sensitizers such as Photofrin and 'HPD'. A brief summary of other clinical-toxicity findings is reported.
Webber
J
J
Department of Surgery, Wayne State University, Detroit, MI 48201, USA.
Kessel
D
D
Fromm
D
D
D000284:Administration, Oral; D000368:Aged; D000622:Aminolevulinic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017319:Photosensitizing Agents / Q000097:blood*; D011524:Protoporphyrins / Q000097:blood*; D013050:Spectrometry, Fluorescence
D017319:Photosensitizing Agents; D011524:Protoporphyrins; D000622:Aminolevulinic Acid; C028025:protoporphyrin IX