Striatal dopamine D1 receptors in narcolepsy: a PET study with [11C]NNC 756.
We investigated dopamine D1 receptors in the putamen and caudate nucleus with positron emission tomography in six patients with narcolepsy and five healthy controls using [11C]NNC 756 as ligand. The caudate-to-cerebellum and putamen-to-cerebellum ratios of [11C]NNC 756 were within normal limits in patients with narcolepsy. No evidence of increased D1 receptor binding in narcolepsy was found.
Rinne
J O
JO
Department of Neurology, University of Turku, Finland.
Hublin
C
C
Partinen
M
M
Ruottinen
H
H
Någren
K
K
Lehikoinen
P
P
Ruotsalainen
U
U
Laihinen
A
A
D000328:Adult; D001665:Binding Sites; D002421:Caudate Nucleus / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000378:metabolism*; D011699:Putamen / Q000378:metabolism*; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D014055:Tomography, Emission-Computed
D017448:Receptors, Dopamine D2; D004298:Dopamine