title: Brasiliquinones A, B and C, new benz[alpha]anthraquinone antibiotics from Nocardia brasiliensis. I. Producing strain, isolation and biological activities of the antibiotics.
abstract: New benz[alpha]anthraquinone antibiotics (brasiliquinones A, B and C) with an ethyl group at C-3 were isolated. The producer was identified as Nocardia brasiliensis. The antibiotics were active against Gram-positive bacteria including Mycobacterium sp., but not active against Gram-negative bacteria or fungi. They were also active against multiple drug-resistant P388/ADR tumor cells.
authors.affiliation: Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Nemoto
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Karasaki
authors.forename: H
authors.initials: H
authors.lastname: Komaki
authors.forename: K
authors.initials: K
authors.lastname: Yazawa
authors.forename: Y
authors.initials: Y
authors.lastname: Mikami
authors.forename: T
authors.initials: T
authors.lastname: Tojo
authors.forename: K
authors.initials: K
authors.lastname: Kadowaki
authors.forename: M
authors.initials: M
authors.lastname: Tsuda
authors.forename: J
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D051379:Mice; D009615:Nocardia / Q000145:classification / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D000880:Anthraquinones; D000900:Anti-Bacterial Agents; C104992:brasiliquinone A; C104993:brasiliquinone B; C104994:brasiliquinone C