title: Dose-dependent protective effect of BPC 157 on capsaicin-induced rhinitis in rats.
abstract: Protection of BPC 157 on capsaicin-induced rhinitis was studied in Wistar rats for its effect on mastocyte infiltration, degranulation and inflammatory cell infiltration. Animals were pretreated with 10 microg/kg, 10 ng/kg or 2 ml saline i.p. and capsaicin (0.05 ml/nostril of 1750 nmol/l sol.) was applied intranasally. They were then euthanized at 1, 3 and 12 h after capsaicin provocation. Nasal mucosa was analyzed and scored for mastocyte infiltration, degranulation and inflammatory cell infiltration. BPC 157 pretreatment significantly prevented mastocyte infiltration at 1 h. Polymorphonuclear leukocyte infiltration was significantly reduced in rats pretreated with 10 microg/kg BPC 157. A dose-dependent effect of BPC 157 pretreatment was demonstrated only for polymorphonuclear leukocyte infiltration at 12 h.
authors.affiliation: Department of Otolaryngology/Head & Neck Surgery, University Hospital Sestre milosrdnice, Zagreb, Croatia.
authors.forename: L
authors.initials: L
authors.lastname: Kalogjera
authors.forename: M
authors.initials: M
authors.lastname: Ries
authors.forename: T
authors.initials: T
authors.lastname: Baudoin
authors.forename: Z
authors.initials: Z
authors.lastname: Ferencic
authors.forename: R
authors.initials: R
authors.lastname: Trotic
authors.forename: B
authors.initials: B
authors.lastname: Pegan
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D002211:Capsaicin / Q000008:administration & dosage / Q000009:adverse effects*; D002452:Cell Count; D015550:Cell Degranulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007249:Inflammation; D007274:Injections, Intraperitoneal; D008214:Lymphocytes / Q000187:drug effects / Q000473:pathology; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000473:pathology; D009297:Nasal Mucosa / Q000187:drug effects / Q000473:pathology; D009299:Nasal Provocation Tests; D009504:Neutrophils / Q000187:drug effects / Q000473:pathology; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D011506:Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012220:Rhinitis / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D012965:Sodium Chloride
chemical_list: D010446:Peptide Fragments; D011506:Proteins; D012965:Sodium Chloride; C083833:BPC 157; D002211:Capsaicin