HLA-DMA and DMB genotyping in patients with rheumatoid arthritis.
OBJECTIVE
To investigate the relation of HLA-DMA and DMB alleles to the development of rheumatoid arthritis (RA).


METHODS
We studied HLA-DMA and DMB alleles in 153 patients with RA and 138 healthy controls using the amplification created restriction site method and digestion with restriction enzymes.


RESULTS
There was no significant difference in frequencies of HLA-DMA and DMB alleles between patients with RA and controls. The HLA-DMA and DMB alleles were not related to extraarticular involvement, seropositivity for rheumatoid factor, or bone erosion. There was also no significant difference in frequencies of HLA-DMA and DMB alleles among DR4-positive and DR4-negative patients and controls.


CONCLUSIONS
HLA-DMA and DMB do not appear to be associated with the pathogenesis of RA.
Yen
J H
JH
Department of Internal Medicine, Kaohsiung Medical College, Kaohsiung City, Taiwan.
Chen
C J
CJ
Tsai
W C
WC
Tsai
J J
JJ
Chang
J G
JG
Liu
H W
HW
D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000235:genetics*; D001862:Bone Resorption / Q000235:genetics; D005787:Gene Frequency; D005838:Genotype; D006681:HLA-D Antigens / Q000235:genetics*; D000949:Histocompatibility Antigens Class II; D006801:Humans; D015995:Prevalence; D012217:Rheumatoid Factor / Q000235:genetics
C416189:H2-M antigens; D006681:HLA-D Antigens; C084245:HLA-DM antigens; D000949:Histocompatibility Antigens Class II; D012217:Rheumatoid Factor