title: In vitro susceptibility of Trichophyton rubrum isolates to griseofulvin and tioconazole. Induction and isolation of a resistant mutant to both antimycotic drugs. Mutant of Trichophyton rubrum resistant to griseofulvin and tioconazole.
abstract: The in vitro susceptibility of three clinical Trichophyton rubrum isolates to griseofulvin and tioconazole, determined by the minimal inhibitory concentration (MIC), was 2 and 0.5 to 1.0 micrograms/ml, respectively. One mutant (gril) obtained after mutagenic treatment of one of these isolates was selected and showed simultaneous resistance to griseofulvin (MIC > 2000 micrograms/ml) and tioconazole (MIC = 1.0 microgram/ml). The clinical importance and the possibility of a multidrug resistance (MDR)-type mechanism being involved in this event is discussed.
authors.affiliation: Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, USP, Brazil.
authors.forename: A L
authors.initials: AL
authors.lastname: Fachin
authors.forename: C M
authors.initials: CM
authors.lastname: Maffei
authors.forename: N M
authors.initials: NM
authors.lastname: Martinez-Rossi
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial / Q000235:genetics; D006118:Griseofulvin / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009154:Mutation; D014249:Trichophyton / Q000187:drug effects* / Q000235:genetics
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; D006118:Griseofulvin; C020527:tioconazole