Gastrointestinal protection by NO from NSAIDs induced injury.
One of the most deleterious side effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) is gastric injury. In order to prevent this, attempt has been made to make novel nitric oxide (NO) releasing NSAIDs. The NO-releasing moiety (nitroxybutylester), which is combined with NSAIDs, has been shown to be responsible for gastrointestinal protection. Various NO-releasing NSAIDs have been compared with their parent compounds and marked decrease in gastrointestinal side effects were observed in the former case. Various animal studies have been done in this context. However, exact mechanism of action of NO-releasing NSAIDs is not clear.
Rishi
R K
RK
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi.
Kishore
K
K
Seth
S D
SD
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005767:Gastrointestinal Diseases / Q000139:chemically induced* / Q000517:prevention & control*; D006801:Humans; D009569:Nitric Oxide / Q000493:pharmacokinetics / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009569:Nitric Oxide