Metabolic inactivation and efflux of daunorubicin as complementary mechanisms in tumor cell resistance.
Soldan
M
M
Department of Pharmacology and Toxicology, Philipps-University of Marburg, Germany.
Maser
E
E
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis*; D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000449:Aldehyde Reductase / Q000378:metabolism; D000074408:Aldo-Keto Reductases; D001711:Biotransformation; D003630:Daunorubicin / Q000493:pharmacokinetics* / Q000633:toxicity*; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D008954:Models, Biological; D010088:Oxidoreductases / Q000378:metabolism; D010190:Pancreatic Neoplasms; D011794:Quercetin / Q000031:analogs & derivatives / Q000494:pharmacology; D012431:Rutin / Q000494:pharmacology; D014158:Transcription, Genetic / Q000187:drug effects; D014407:Tumor Cells, Cultured
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D007527:Isoenzymes; C012526:quercitrin; D012431:Rutin; D011794:Quercetin; D010088:Oxidoreductases; D000429:Alcohol Oxidoreductases; D000074408:Aldo-Keto Reductases; D000449:Aldehyde Reductase; C048338:trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; D003630:Daunorubicin