Failure of insulin-like growth factor 1 to improve radiocontrast nephropathy.
Exogenous insulin-like growth factor 1 (IGF-1) has been reported to improve experimental ischemic acute renal failure. We investigated a possible beneficial role of IGF-1 in a model of radiocontrast nephropathy induced by indomethacin, nitro-L-arginine ester and iothalamate. Multiple injections of recombinant human IGF-1 (or its vehicle) at 150 microg/100 g body weight/day were given for 24 h starting 1 h after radiocontrast, or initiated 1 day after the insults and continued for 48 h. IGF-1 prevented neither the fall in creatinine clearance nor medullary thick ascending limb necrosis observed at 24 h. Similarly IGF-1, given for 2 days after renal failure had been established, did not accelerate functional recovery at 72 h, did not ameliorate catabolism and did not alter the morphological evolution of intrarenal damage. In conclusion, IGF-1 had no beneficial effects in this model of radiocontrast nephropathy.
Fuchs
S
S
Department of Medicine, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel.
Yaffe
R
R
Beeri
R
R
Rosen
S
S
Heyman
S N
SN
Brezis
M
M
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D001710:Biotin; D003287:Contrast Media / Q000633:toxicity*; D003404:Creatinine / Q000378:metabolism; D053938:DNA Fragmentation; D003856:Deoxyuracil Nucleotides; D004195:Disease Models, Animal; D006801:Humans; D007213:Indomethacin / Q000633:toxicity; D007334:Insulin-Like Growth Factor I / Q000378:metabolism / Q000494:pharmacology*; D007483:Iothalamic Acid / Q000633:toxicity; D008297:Male; D009336:Necrosis; D019335:Nitroarginine / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000097:blood / Q000494:pharmacology; D012079:Renal Circulation; D013194:Staining and Labeling
D003287:Contrast Media; D003856:Deoxyuracil Nucleotides; D011994:Recombinant Proteins; D007483:Iothalamic Acid; D019335:Nitroarginine; D007334:Insulin-Like Growth Factor I; D001710:Biotin; D003404:Creatinine; D007213:Indomethacin