Novel reduction and hydroxylation products formed by Aspergillus fumigatus from Reichstein's substance S.
Fermentation of Reichstein's Substance S with Aspergillus fumigatus (AM-21) under aerobic conditions yielded 17 alpha, 21-dihydroxy-5 alpha-pregn-l-ene-3.20-dione. 17 alpha,20 alpha, 21-trihydroxy-5 alpha-pregn-l-en-3-one. 6 beta,17 alpha, 21-trihydroxypregn-4-en-3,20-dione. 15 beta,17 alpha,21-trihydroxy-5 alpha-pregnane-3,20-dione, and 15 beta, 17 alpha,20 alpha,21-tetrahydroxy-5 alpha-pregn-l-en-3-one. Each microbial metabolite was characterized by spectroscopic methods, including 13C NMR chemical shifts.
Garai
S
S
Indian Institute of Chemical Biology, Calcutta, India.
Mahato
S B
SB
D001232:Aspergillus fumigatus / Q000378:metabolism*; D003350:Cortodoxone / Q000737:chemistry*; D005285:Fermentation; D006900:Hydroxylation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010084:Oxidation-Reduction; D013256:Steroids / Q000096:biosynthesis* / Q000737:chemistry
D013256:Steroids; D003350:Cortodoxone