title: [Is radiotherapy still the first choice treatment in spinal metastases from breast cancer?].
abstract: The skeletal system is a frequent site of metastatic involvement from breast cancer, whose pattern of spread is such that cure becomes practically impossible. The best palliation with the minimum discomfort for the patient must therefore be the major objective. With an increasing number of reports about major surgical procedures for spinal metastases, we reviewed our series of patients submitted to radiotherapy. Of 2,189 breast cancer patients, we selected 28 who might have been potential candidates for surgical resection (with lesions only in the spine, only one or no more than three contiguous bodies involved and no other metastases). All these patients had been treated with 20 or 30 Gy plus systemic (chemo, hormone, or both) therapy. Follow-up revealed that all of them had developed new metastases outside the treated field within one year. Local control was achieved in 68% of patients and 75% of them had stable or better performance status at 3 months. Median survival was 36 months. From our analysis, even patients with a so called "solitary lesion" seem not to have a better prognosis than others. We conclude that radiotherapy is still the method of choice to treat vertebral metastases from breast cancer. The role of surgery should be limited to patients with neurologic compression or severe mechanical instability.
authors.affiliation: Centro di Oncologia Ortopedica, 1 Ortopedia, Ospedale Civile, Brescia.
authors.forename: E
authors.initials: E
authors.lastname: Micheletti
authors.forename: V
authors.initials: V
authors.lastname: Ippolito
authors.forename: S
authors.initials: S
authors.lastname: Tonoli
authors.forename: F
authors.initials: F
authors.lastname: Barbera
authors.forename: M
authors.initials: M
authors.lastname: Saccalani
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology*; D005500:Follow-Up Studies; D006801:Humans; D012189:Retrospective Studies; D013120:Spinal Cord Neoplasms / Q000532:radiotherapy* / Q000556:secondary*
vernacular_title: La radioterapia è ancora il trattamento di prima scelta delle metastasi vertebrali da cancro della mammella?