Insulin therapy in type II diabetes: who needs it, how much of it, and for how long?
Insulin therapy can control glucose levels in patients with type II diabetes. Because of insulin resistance, high doses may be required initially to attain satisfactory control; however, also because of insulin resistance, hypoglycemia with insulin therapy is much less common among patients with type II diabetes than among those with type I diabetes. Insulin therapy need not be permanent. In some cases, temporary worsening of disease is the result of glucose toxicity and insulin can be discontinued or doses reduced when disease severity subsides. On the other hand, beta-cell failure is progressive, and with long duration of diabetes, permanent insulin therapy may be necessary to achieve satisfactory glucose control.
Skyler
J S
JS
Division of Endocrinology, University of Miami School of Medicine, FL 33136, USA. jskyler@mednet.med.miami.edu
D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000145:classification / Q000188:drug therapy* / Q000378:metabolism; D004359:Drug Therapy, Combination; D006801:Humans; D007004:Hypoglycemic Agents / Q000378:metabolism / Q000627:therapeutic use*; D007328:Insulin / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D007333:Insulin Resistance
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin