Aminoacyl-tRNA synthesis: divergent routes to a common goal.
Aminoacyl-tRNAs are key components in protein synthesis. They are formed directly by correct acylation of tRNA (by aminoacyl-tRNA synthetases) or indirectly by tRNA-dependent transformation of misacylated tRNAs. The accuracy of aminoacyl-tRNA synthesis is enhanced by a number of further protein-RNA or protein-protein interactions, some of which are restricted to Archaea, and might reflect adaptation mechanisms to diverse conditions.
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Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520-8114, USA.
Curnow
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Söll
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D000604:Amino Acyl-tRNA Synthetases / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D012346:RNA, Transfer, Amino Acyl / Q000096:biosynthesis*
D012346:RNA, Transfer, Amino Acyl; D000604:Amino Acyl-tRNA Synthetases