Chemosensory-event-related potentials to olfactory stimulations.
Odorant pulses were introduced into the noses of 18 healthy volunteers by using a pressurized nasal spray. Just prior to the onset of inspiration, the spray tip was inserted 1 cm into the nostril as atraumatically as possible. The odorant pulse trigger was the subject's respiration. Responses to aerosolized skatole consisted mainly of a positive wave with a peak latency of 147.1 +/- 5.3 ms. These positive waves were distinguishable as an evoked response by employing curve superimpositions before and after averaging positive responses. In our cases, saturation of responses was found after 4-5 averagings with the response becoming most clear after 7-8 averagings. The response peak latency to more concentrated skatole was consistently shorter by 9-19 ms than that to 10% diluted skatole in all subjects tested.
Wada
M
M
Department of Otorhinolaryngology, National Center of Neurology and Psychiatry, Kohnodai Hospital, Chiba, Japan.
D000281:Administration, Intranasal; D000328:Adult; D000336:Aerosols; D001547:Benzaldehydes / Q000008:administration & dosage / Q000494:pharmacology; D002628:Chemoreceptor Cells / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology*; D005421:Flavoring Agents / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D001239:Inhalation; D008297:Male; D009666:Nose / Q000502:physiology; D009812:Odorants; D010812:Physical Stimulation; D011930:Reaction Time / Q000187:drug effects; D012862:Skatole / Q000008:administration & dosage / Q000494:pharmacology; D012903:Smell / Q000502:physiology*
D000336:Aerosols; D001547:Benzaldehydes; D005421:Flavoring Agents; D012862:Skatole; C100058:vanillin