title: 99Tcm-N,N-ethylenedicysteine scintigraphy in children with various renal disorders: a comparative study with 99Tcm-MAG3.
abstract: We evaluated the clinical usefulness of 99Tcm-N,N-ethylenedicysteine (99Tcm-EC), a new renal tubular agent, in normal children and in children with various renal disorders and compared it with 99Tcm-mercaptoacetyltriglycine (99Tcm-MAG3). In a first group of children (Group 1), which included 15 patients and 4 normal children, both 99Tcm-EC and 99Tcm-MAG3 renal scintigraphy were performed within a period of 1-5 days. In a second group (Group 2), consisting of 12 patients, only 99Tcm-EC scintigraphy was performed. In the normal children, renograms, differential renal function (DRF) ratios and semi-quantitative parameters of the two agents were similar. For 99Tcm-EC and 99Tcm-MAG3, the mean (+/- S.D.) time to peak activity (Tmax) values were 3.2 +/- 0.5 and 3.1 +/- 0.4 min respectively, and the mean time from peak activity to 50% activity (T1/2) values were 6.3 +/- 0.5 and 6.4 +/- 0.4 min respectively. The mean parenchymal transit time index (PTTI) and mean whole-kidney transit time index (WKTTI) for 99Tcm-EC were 1.7 +/- 0.3 and 2.8 +/- 0.4 respectively, and for 99Tcm-MAG3 they were 1.8 +/- 0.2 and 3.0 +/- 0.3 min respectively. There were also no significant differences between these parameters for the two agents in children with various renal disorders, and the correlation coefficients (r) for DRF, Tmax, T1/2, PTTI and WKTTI were 0.99, 0.98, 0.94, 0.77 and 0.63 respectively. We conclude that 99Tcm-EC has excellent imaging characteristics in children, and even has some advantages over 99Tcm-MAG3. We suggest this agent can be used routinely with children.
authors.affiliation: Department of Nuclear Medicine, Cukurova Universitesi Tip Fakültesi, Nükleer Tip Anabilim Dali, Adana, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Kibar
authors.forename: A
authors.initials: A
authors.lastname: Noyan
authors.forename: A
authors.initials: A
authors.lastname: Anarat
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003545:Cysteine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005260:Female; D015902:Gamma Cameras; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging* / Q000502:physiology / Q000503:physiopathology; D007674:Kidney Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000000981:diagnostic imaging; D007677:Kidney Function Tests; D008297:Male; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D012016:Reference Values; D012044:Regression Analysis; D017263:Technetium Tc 99m Mertiatide / Q000493:pharmacokinetics; D014055:Tomography, Emission-Computed
chemical_list: D015609:Organotechnetium Compounds; C073806:technetium Tc 99m-ethylenedicysteine; D017263:Technetium Tc 99m Mertiatide; D003545:Cysteine