Slow dendritic transport of dissociated mouse hippocampal neurons exposed to aluminum.
We determined the influence of aluminum on dendritic transport, using an in vitro system of dissociated mouse hippocampal neurons. Newly synthesized RNA from dissociated mouse hippocampal neurons was more slowly transported into dendrites in the presence of aluminum chloride when compared to those without the addition of aluminum chloride to the culture medium. Suppression of dendritic transport of newly synthesized RNA may be responsible for the dendritic degeneration observed in aluminum neurotoxicity, eventually leading to neuronal degeneration.
Wakayama
I
I
Research Center of Neurological Diseases, Kansai College of Oriental Medicine, Kumatori, Osaka, Japan.
Song
K J
KJ
Nerurkar
V R
VR
Yoshida
S
S
Garruto
R M
RM
D000535:Aluminum / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003712:Dendrites / Q000378:metabolism*; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D009474:Neurons / Q000378:metabolism*; D012313:RNA / Q000378:metabolism
D012313:RNA; D000535:Aluminum