title: High intensity of oral anticoagulant therapy in patients with cerebral haemorrhage: cause or consequence of the bleeding?
abstract: In assessing the optimal intensity of anticoagulant therapy, the International Normalized Ratio (INR) at admission is used as a basis for INR-specific incidence rates. In 47 patients suffering a haemorrhagic stroke we tested the assumption that the INR at admission is an acceptable measure for the INR that preceded the haemorrhage. We found high D-dimer levels in 70% of the patients, which indicated activated coagulation and fibrinolysis. This was not of such an extent that it could also be measured with other routine coagulation tests, with the possible exception of two patients. We found normal INRs in 33 non-anticoagulated patients, and only a mildly prolonged INR of 1.9 in one patient, which was most probably caused by a vitamin K deficiency. We concluded that the INR at admission can be used in studies to assess the optimal level of anticoagulation.
authors.affiliation: Haemostasis and Thrombosis Research Centre, Department of Haematology, University Hospital Leiden, The Netherlands.
authors.forename: S C
authors.initials: SC
authors.lastname: Cannegieter
authors.forename: F R
authors.initials: FR
authors.lastname: Rosendaal
authors.forename: E L
authors.initials: EL
authors.lastname: Bollen
authors.forename: E
authors.initials: E
authors.lastname: Briët
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001778:Blood Coagulation Disorders / Q000188:drug therapy; D002543:Cerebral Hemorrhage / Q000139:chemically induced*; D002561:Cerebrovascular Disorders / Q000209:etiology; D005169:Factor VIII / Q000032:analysis; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D005169:Factor VIII; D005340:Fibrinogen