title: The effect of intravenous aminophylline on essential tremor.
abstract: OBJECTIVE
  The effects of intravenous aminophylline (375 mg) or placebo (saline) were studied in 10 patients with benign essential tremor.
  
  
  METHODS
  This was a single-blind crossover study. Patients received aminophylline by i.v. infusion over 15 min or saline at least 1 week apart. Tremor was measured by a peizoresistive accelerometer at 15 min intervals predose and up to 2 h. Plasma theophylline concentrations were measured by h.p.l.c.
  
  
  RESULTS
  Tremor power was significantly greater following aminophylline (5.67-6.2 Hz) than placebo (5.6-5.9 Hz).
  
  
  CONCLUSIONS
  We conclude that intravenous aminophylline potentiates benign essential tremor when given acutely by the intravenous route in the doses required to achieve therapeutic benefits in asthma.
authors.affiliation: Department of Pharmacology, University of Wales College of Medicine, Heath Park, Cardiff, UK.
authors.forename: D C
authors.initials: DC
authors.lastname: Buss
authors.forename: R W
authors.initials: RW
authors.lastname: Marshall
authors.forename: N
authors.initials: N
authors.lastname: Milligan
authors.forename: I
authors.initials: I
authors.lastname: McQueen
authors.forename: D A
authors.initials: DA
authors.lastname: Compston
authors.forename: P A
authors.initials: PA
authors.lastname: Routledge
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000628:Aminophylline / Q000627:therapeutic use*; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D016037:Single-Blind Method; D013806:Theophylline / Q000097:blood; D014202:Tremor / Q000188:drug therapy*
chemical_list: D001993:Bronchodilator Agents; D000628:Aminophylline; D013806:Theophylline