title: Ester-type cephalotaxus alkaloids from Cephalotaxus harringtonia var. drupacea.
abstract: Three alkaloids, neoharringtonine, homoneoharringtonine and 3'S-hydroxyneoharringtonine, were isolated from the leaves and stems of Cephalotaxus harringtonia var. drupacea. Their structures were established by spectroscopic methods, including two-dimensional NMR and CD spectra, and their antileukaemic activity was evaluated using P-388 leukaemia cells.
authors.affiliation: Tokyo Metropolitan Research Laboratory of Public Health, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Takano
authors.forename: I
authors.initials: I
authors.lastname: Yasuda
authors.forename: M
authors.initials: M
authors.lastname: Nishijima
authors.forename: Y
authors.initials: Y
authors.lastname: Yanagi
authors.forename: K
authors.initials: K
authors.lastname: Takeya
authors.forename: H
authors.initials: H
authors.lastname: Itokawa
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D002942:Circular Dichroism; D007941:Leukemia P388 / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010944:Plants / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014407:Tumor Cells, Cultured
chemical_list: D000470:Alkaloids