title: Argenteanones C-E and argenteanols B-E, cytotoxic cycloartanes from Aglaia argentea.
abstract: Seven new cycloartanes, argenteanones C-E (4-6) and argenteanols B-E (7-10), have been isolated from Aglaia argentea leaves. All of these compounds possess significant cytotoxic activity against KB cells (IC50 values between 3.7 and 6.2 micrograms/mL). Structure elucidation was performed by 2D NMR spectroscopy, aided by molecular modeling in the case of the side chain of compound 7.
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France.
authors.forename: K
authors.initials: K
authors.lastname: Mohamad
authors.forename: M T
authors.initials: MT
authors.lastname: Martin
authors.forename: E
authors.initials: E
authors.lastname: Leroy
authors.forename: C
authors.initials: C
authors.lastname: Tempête
authors.forename: T
authors.initials: T
authors.lastname: Sévenet
authors.forename: K
authors.initials: K
authors.lastname: Awang
authors.forename: M
authors.initials: M
authors.lastname: Païs
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D018515:Plant Leaves / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism; D014315:Triterpenes; D014407:Tumor Cells, Cultured
chemical_list: D012503:Saponins; D014315:Triterpenes; C085352:cycloartane