[Diagnostic value of serum soluble interleukin-2 receptor levels in interstitial pneumonia of the patients with hematological disorders].
Serum levels of soluble interleukin-2 receptor (SIL-2R) and C-reactive protein (CRP) were measured in 12 patients with interstitial pneumonia (IP) and 10 patients with bacterial pneumonia (BP) of hematological malignancies. Mean SIL-2R levels (U/ml) were 394 +/- 140 in normal controls, 755 +/- 320 in BP, and 2328 +/- 943 in IP. A significantly higher level was found in IP than BP (p < 0.05). Moreover, the SIL-2R/CRP ratio which was over 260 in all cases of IP completely distinguished IP from BP. Levels of SIL-2R rose before the onset of IP and were closely associated with clinical course in most cases. From these results, measurement of serum SIL-2R may be useful for the diagnosis and monitoring of the clinical course of IP complicated with hematological diseases.
Kohda
K
K
Department of Hematology, Japanese Red Cross Asahikawa Hospital.
Koike
K
K
Matsumoto
S
S
Kida
M
M
Nakazawa
O
O
Nagamachi
Y
Y
Mizushima
S
S
D002097:C-Reactive Protein / Q000032:analysis; D019337:Hematologic Neoplasms / Q000150:complications*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000175:diagnosis; D015375:Receptors, Interleukin-2 / Q000097:blood*
D015375:Receptors, Interleukin-2; D002097:C-Reactive Protein