title: Systemic sclerosis associated with diabetes insipidus.
abstract: A rare case of systemic sclerosis that preceded the development of diabetes insipidus is reported. This 25-year-old man presented with Raynaud's phenomenon and ulceration of the tip of the right thumb. The diagnosis of systemic sclerosis was based on findings of proximal scleroderma, sclerodactyly, serological abnormalities, and skin abnormalities verified histologically. Partial central diabetes insipidus was later diagnosed after the sudden appearance of polyuria and polydipsia. Coexistence of systemic sclerosis with diabetes insipidus suggests that diabetes insipidus in this patient might have occurred via an autoimmune mechanism.
authors.affiliation: Second Department of Medicine, Kurume University School of Medicine.
authors.forename: M
authors.initials: M
authors.lastname: Harada
authors.forename: H
authors.initials: H
authors.lastname: Yoshida
authors.forename: Y
authors.initials: Y
authors.lastname: Mimura
authors.forename: K
authors.initials: K
authors.lastname: Ohtsubo
authors.forename: T
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: S
authors.initials: S
authors.lastname: Murashima
authors.forename: K
authors.initials: K
authors.lastname: Sasatomi
authors.forename: A
authors.initials: A
authors.lastname: Komai
authors.forename: M
authors.initials: M
authors.lastname: Miyazato
authors.forename: T
authors.initials: T
authors.lastname: Iwao
authors.forename: M
authors.initials: M
authors.lastname: Sata
authors.forename: K
authors.initials: K
authors.lastname: Tanikawa
mesh_terms: D000328:Adult; D015551:Autoimmunity; D003919:Diabetes Insipidus / Q000150:complications* / Q000209:etiology / Q000276:immunology; D006801:Humans; D008297:Male; D011928:Raynaud Disease / Q000150:complications; D012595:Scleroderma, Systemic / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D012883:Skin Ulcer / Q000150:complications