[The effect of the acetylation phenotype on the course severity and outcome of acute viral hepatitis B].
Acetylation phenotype was studied in 70 inpatients with acute viral hepatitis B. Of them, 51 had fast and 19 slow acetylation. Fast-type acetylation was associated with mild-severe form of hepatitis B, while slow-type acetylation--with recurrences and aggravations, severe form of hepatitis. The duration of HB antigenemia in the slow-type group was twice as long as in the fast-type group. Two patients, "slow acetylators", suffered from hepatitis B in the mild-severe form, later on chronic active hepatitis (CAH) developed. In "fast" acetylators the development of CAH was not observed. Thus, determination of phenotype by acetylation may be used for prognosis of acute viral hepatitis severity as well as for identification of high-risk groups and planning policy of follow-up.
Usmanova
L P
LP
Kasimova
N B
NB
Kuznetsova
T A
TA
Kotel'nikova
L I
LI
Bogdanova
A G
AG
Cherenova
O P
OP
D000107:Acetylation; D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D006509:Hepatitis B / Q000276:immunology / Q000652:urine*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006801:Humans; D008875:Middle Aged; D010641:Phenotype; D011379:Prognosis; D012008:Recurrence; D012720:Severity of Illness Index; D000077589:Sulfathiazole; D013432:Sulfathiazoles / Q000652:urine
D006514:Hepatitis B Surface Antigens; D013432:Sulfathiazoles; D000077589:Sulfathiazole
Vliianie fenotipa atsetilirovaniia na tiazhest' techeniia i iskhody ostrogo virusnogo gepatita B.