Dose-dependent protective effect of BPC 157 on capsaicin-induced rhinitis in rats.
Protection of BPC 157 on capsaicin-induced rhinitis was studied in Wistar rats for its effect on mastocyte infiltration, degranulation and inflammatory cell infiltration. Animals were pretreated with 10 microg/kg, 10 ng/kg or 2 ml saline i.p. and capsaicin (0.05 ml/nostril of 1750 nmol/l sol.) was applied intranasally. They were then euthanized at 1, 3 and 12 h after capsaicin provocation. Nasal mucosa was analyzed and scored for mastocyte infiltration, degranulation and inflammatory cell infiltration. BPC 157 pretreatment significantly prevented mastocyte infiltration at 1 h. Polymorphonuclear leukocyte infiltration was significantly reduced in rats pretreated with 10 microg/kg BPC 157. A dose-dependent effect of BPC 157 pretreatment was demonstrated only for polymorphonuclear leukocyte infiltration at 12 h.
Kalogjera
L
L
Department of Otolaryngology/Head & Neck Surgery, University Hospital Sestre milosrdnice, Zagreb, Croatia.
Ries
M
M
Baudoin
T
T
Ferencic
Z
Z
Trotic
R
R
Pegan
B
B
D000281:Administration, Intranasal; D000818:Animals; D002211:Capsaicin / Q000008:administration & dosage / Q000009:adverse effects*; D002452:Cell Count; D015550:Cell Degranulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007249:Inflammation; D007274:Injections, Intraperitoneal; D008214:Lymphocytes / Q000187:drug effects / Q000473:pathology; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000473:pathology; D009297:Nasal Mucosa / Q000187:drug effects / Q000473:pathology; D009299:Nasal Provocation Tests; D009504:Neutrophils / Q000187:drug effects / Q000473:pathology; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D011506:Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012220:Rhinitis / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D012965:Sodium Chloride
D010446:Peptide Fragments; D011506:Proteins; D012965:Sodium Chloride; C083833:BPC 157; D002211:Capsaicin