title: Human hepatocyte nuclear factor-4 (hHNF-4) gene maps to 20q12-q13.1 between PLCG1 and D20S17.
abstract: Human hepatocyte nuclear factor 4 (hHNF-4) is a member of the nuclear hormone receptor superfamily and an important transcription factor and developmental regulator of liver-specific genes. Distinct hHNF-4 cDNAs corresponding to various HNF-4 isoforms have been recently characterised. Three cDNAs, hHNF-4A, B and C, are considered splice variants of a single hHNF-4 gene. We have mapped hHNF-4 to 20q12-q13.1 between PLCG1 and D20S17 by genetic linkage analysis, taking advantage of an adjacent PstI restriction fragment length polymorphism, (RFLP), and by fluorescence in situ hybridisation. hHFN-4 maps to chromosome 20 in a region syntenic with mouse chromosome 2 where the hnf-4 homologue has been assigned.
authors.affiliation: Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology, Heraklion, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Argyrokastritis
authors.forename: S
authors.initials: S
authors.lastname: Kamakari
authors.forename: M
authors.initials: M
authors.lastname: Kapsetaki
authors.forename: A
authors.initials: A
authors.lastname: Kritis
authors.forename: I
authors.initials: I
authors.lastname: Talianidis
authors.forename: N K
authors.initials: NK
authors.lastname: Moschonas
mesh_terms: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D002874:Chromosome Mapping; D002890:Chromosomes, Human, Pair 20; D004268:DNA-Binding Proteins; D008040:Genetic Linkage; D005819:Genetic Markers; D051557:Hepatocyte Nuclear Factor 4; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007527:Isoenzymes / Q000235:genetics; D051966:Phospholipase C gamma; D010750:Phosphoproteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D014157:Transcription Factors / Q000235:genetics*; D010738:Type C Phospholipases / Q000235:genetics
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D004268:DNA-Binding Proteins; D005819:Genetic Markers; D051557:Hepatocyte Nuclear Factor 4; D007527:Isoenzymes; C403128:MLX protein, human; D010750:Phosphoproteins; C501970:Tcfl4 protein, mouse; D014157:Transcription Factors; D010738:Type C Phospholipases; D051966:Phospholipase C gamma