title: Evaluation of the international index in the prognosis of high grade gastric malt lymphoma.
abstract: The International Prognostic Index identifies four risk groups with different survival rates in aggressive non-Hodgkin's lymphoma. We have studied whether a slight modification of this index has prognostic significance in high grade gastric B-cell MALT lymphoma. In 53 patients with high grade gastric B-cell MALT lymphoma the following survival factors were investigated: age over or under 60 years, sex, B symptoms, more than one extranodal site of involvement other than the stomach, serum LDH levels, performance status, stage I/IIE1/IIE2 v.s. stage III/IV, treatment with surgery, chemotherapy or both modalities together and the four risk groups as defined by the Modified International Prognostic Index (MIPI). A multivariate Cox's test was used to evaluate the independent prognostic significance on survival of all the above variables. Advanced stage (III/IV) and involvement of more than one extranodal site not including stomach were the only variables influencing survival. The MIPI was not sufficient to separate groups with significant differences in survival or to stratify prognostic groups. In this series, the MIPI did not show prognostic significance in high grade gastric B-cell MALT lymphoma.
authors.affiliation: Department of Internal Medicine, Fundación Jimenez Díaz, Universidad Autónoma, Madrid, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Castrillo
authors.forename: C
authors.initials: C
authors.lastname: Montalbán
authors.forename: V
authors.initials: V
authors.lastname: Abraira
authors.forename: R
authors.initials: R
authors.lastname: Carrion
authors.forename: M A
authors.initials: MA
authors.lastname: Cruz
authors.forename: J G
authors.initials: JG
authors.lastname: Laraña
authors.forename: J
authors.initials: J
authors.lastname: Menarguez
authors.forename: C
authors.initials: C
authors.lastname: Bellas
authors.forename: M A
authors.initials: MA
authors.lastname: Piris
authors.forename: F
authors.initials: F
authors.lastname: Gomez-Marcos
authors.forename: M
authors.initials: M
authors.lastname: Serrano
authors.forename: C
authors.initials: C
authors.lastname: Rivas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007391:International Cooperation; D018442:Lymphoma, B-Cell, Marginal Zone / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D013274:Stomach Neoplasms / Q000473:pathology*; D015996:Survival Rate