Gene expression of granulocyte colony stimulating factor (G-CSF) in non-small cell lung cancer.
Autonomous or continuous granulocyte colony-stimulating factor. (G-CSF)-production in malignant neoplasms is considered to induce leukocytosis without apparent infection. We examined G-CSF gene expression in human non-small cell lung cancer (NSCLC) and discussed its clinicopathological significance. Northern blot analysis revealed G-CSF gene expression in 14 of 84 surgical specimens (16.7%, 10/30 squamous cell carcinoma, 3/50 adenocarcinoma, 1/4 large cell carcinoma). Eight patients (57.1%, 8/14) with NSCLC showing G-CSF gene-expression had peripheral blood leukocytosis (> 8,000/microliter). The prognosis was significantly worse in 10 stage I or II NSCLC showing G-CSF gene expression (p < 0.01, Cox-Mantel test). These findings suggest that G-CSF gene expression is common event in the early stage of primary NSCLC, while it cannot completely explain the leukocytosis induced by lung cancer.
Nakamura
M
M
Department of Pathology, Tokai University School of Medicine, Kanagawa, Japan.
Oshika
Y
Y
Abe
Y
Y
Ozeki
Y
Y
Katoh
Y
Y
Yamazaki
H
H
Kijima
H
H
Ueyama
Y
Y
Ogata
T
T
Tamaoki
N
N
D000230:Adenocarcinoma / Q000378:metabolism*; D000368:Aged; D018287:Carcinoma, Large Cell / Q000378:metabolism*; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*
D009363:Neoplasm Proteins; D016179:Granulocyte Colony-Stimulating Factor