title: Experience with gestational surrogacy as a treatment for sterility resulting from hysterectomy.
abstract: A retrospective study was carried out to assess the potential of 16 hysterectomized women to achieve surrogate pregnancies. A total of 11 patients completed 16 cycles of assisted conception treatment incorporating in-vitro fertilization and gestational surrogacy. Three other women failed to respond to ovulation induction while two more patients produced few oocytes which also failed to fertilize. Six host mothers became pregnant thereby giving a pregnancy rate of 37.5% (6/16) per patient and embryo transfer and 27.3% (6/22) per cycle of treatment commenced. Two women later miscarried, three have given birth to twins and the remaining host has delivered a male infant. The commissioning mother's age was closely related to occurrence and continuation of pregnancy in the host. Hysterectomized women demonstrate varying patterns of response to assisted conception treatment but gestational surrogacy generally appears to be a feasible option especially in younger patients.
authors.affiliation: London Gynaecology and Fertility Centre, UK.
authors.forename: G I
authors.initials: GI
authors.lastname: Meniru
authors.forename: I L
authors.initials: IL
authors.lastname: Craft
mesh_terms: D000328:Adult; D000375:Aging; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007044:Hysterectomy; D008297:Male; D008875:Middle Aged; D010062:Ovulation Induction; D011247:Pregnancy; D012189:Retrospective Studies; D013533:Gestational Carriers
chemical_list: D005640:Follicle Stimulating Hormone