title: [The pharmacokinetic determinants of the analgesic effect of benzofurocaine in patients with burns and wounds of the joints].
abstract: The non-narcotic analgetic benzofurocaine in intravenous administration at the dose level of 300 mg exerts an apparent analgesic effect in those patients with various pathogenetic mechanisms of the pain syndrome. The pharmacologic effect of the drug depends upon its blood plasma content. The character of the interrelationship is described by hysteresis curve suggesting the pharmacologic effect to be behind the time of building up of maximum blood drug concentration. The pharmacokinetic determinants of the analgesic action of benzofurocaine are the area under the pharmacokinetic curve, half-life period, and average time of drug retention in blood. There is a close direct correlation between the above determinants.
authors.forename: M A
authors.initials: MA
authors.lastname: Stanislavchuk
authors.forename: O O
authors.initials: OO
authors.lastname: Pentiuk
authors.forename: I F
authors.initials: IF
authors.lastname: Semenenko
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000779:Anesthetics, Local / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001572:Benzofurans; D002056:Burns / Q000097:blood* / Q000188:drug therapy; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007592:Joint Diseases / Q000097:blood / Q000188:drug therapy; D007596:Joints / Q000293:injuries*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D000779:Anesthetics, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001572:Benzofurans; C040205:benzofurocaine
vernacular_title: Farmakokinetychni determinanty analhetychnoho efektu benzofurokaïnu u khvorykh z opikamy ta urazhenniam suhlobiv.