Finally! The Brambell receptor (FcRB). Mediator of transmission of immunity and protection from catabolism for IgG.
F. W. Rogers Brambell was the father of the field of transmission of immunity, which he entered 50 years before the present era. As part of his quantitative and temporal studies on transmission, he defined the first Fc receptor system for IgG, and furthermore recognized the link between transmission of passive immunity from mother to young and protection from catabolism for IgG. This article provides a historical overview of the efforts of Professor Brambell and summarizes the subsequent elaboration of the details of the physiology and molecular biology of this remarkable receptor system.
Junghans
R P
RP
Faculty of Immunology, Harvard Medical School, New England Deaconess Hospital, Boston, MA 02215, USA.
D000486:Allergy and Immunology / Q000266:history*; D000818:Animals; D001692:Biological Transport / Q000276:immunology; D004730:Endothelium, Vascular / Q000276:immunology / Q000378:metabolism; D049673:History, 20th Century; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007074:Immunoglobulin G / Q000266:history / Q000276:immunology*; D051379:Mice; D011817:Rabbits; D011961:Receptors, Fc / Q000266:history / Q000276:immunology* / Q000502:physiology; D017452:Receptors, IgG / Q000276:immunology* / Q000502:physiology
D007074:Immunoglobulin G; D011961:Receptors, Fc; D017452:Receptors, IgG