title: Semantic, phonological, and perceptual changes following left and right intracarotid injection (Wada) with a low amytal dosage.
abstract: Intracarotid injection of a low dosage of amobarbital (75 mg, 5% solution) was studied in 30 temporal lobectomy candidates while naming achromatic, incongruously, and congruously colored pictorial objects and reading real, nonsense, and embedded words. Semantic errors and phonological alexia followed the left injection, while the right injection induced visuoperceptual errors. When the contralateral hemisphere was anesthetized, the left brain formulated supraordinate categories for words and objects, while the right brain applied concrete labels. The basic language proficiency of patients influenced recovery and outcome; left temporal patients who were interictally anomic performed especially poorly after both injections. Codifying phonological and perceptual changes during the intracarotid amobarbital procedure can improve interpretations about language laterality and organization.
authors.affiliation: Department of Neuropsychology, National Institute of Neurological Disorders and Stroke and Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: P
authors.initials: P
authors.lastname: Fedio
authors.forename: A
authors.initials: A
authors.lastname: August
authors.forename: N
authors.initials: N
authors.lastname: Patronas
authors.forename: S
authors.initials: S
authors.lastname: Sato
authors.forename: C
authors.initials: C
authors.lastname: Kufta
mesh_terms: D000328:Adult; D000654:Amobarbital / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D002343:Carotid Artery, Internal; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007269:Injections, Intra-Arterial; D007806:Language Disorders / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000175:diagnosis; D010468:Perceptual Disorders / Q000139:chemically induced* / Q000175:diagnosis; D010700:Phonetics; D012660:Semantics
chemical_list: D000654:Amobarbital