Hyperactive behavioural effects induced by intranigral infusion of a pyridinium metabolite of haloperidol in rats.
Amphetamine-like behaviours such as sniffing and head movements were observed in rats intranigrally injected with a pyridinium metabolite of haloperidol (HP+). Photobeam interruptions by rats injected with HP+ were over 200 times more frequent than those of control rats 24 h after the operation. This apparent dopamine agonist effect of HP+ may be relevant to some of the clinical side effects of haloperidol such as acute dystonia and chronic tardive dyskinesia, which have been proposed to be the result of dopaminergic hyperactivity.
Fang
J
J
Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004421:Dystonia / Q000139:chemically induced; D006220:Haloperidol / Q000008:administration & dosage / Q000378:metabolism* / Q000633:toxicity*; D006948:Hyperkinesis / Q000139:chemically induced*; D007276:Injections, Intraventricular; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D011726:Pyridinium Compounds / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013378:Substantia Nigra / Q000187:drug effects*
D011726:Pyridinium Compounds; D006220:Haloperidol