title: Ventricular tachycardia in healing canine myocardial infarction: evidence for multiple reentrant mechanisms.
abstract: Prior studies have demonstrated that unimorphic VT, sometimes due to epicardial reentry, can be induced in healing canine MI; however, the characterization of the types of reentry involved has differed among prior studies. The purpose of this study was to further characterize the spectrum of epicardial reentrant circuits during induced VT in experimental canine MI. Experimental MI was created by total occlusion of the LAD in dogs. Five days later, programmed stimulation was used to induce VT, which was mapped on the epicardium using a combination of vector and isochronal techniques. Pathological analysis was used to determine regions of transmural MI. Epicardial reentrant circuits were identified in eight dogs. The mean cycle length of induced VT was 212 +/- 32 ms. In 3 of 8 experiments, a region of transmural MI was present, which formed at least a portion of a central zone of block around which reentrant impulses circulated. In five experiments, reentry was functional in nature, although the characteristics of the region of functional conduction block were variable. Long lines of functional block, short lines of block with slow conduction transverse to fiber orientation, and leading circle reentry were each observed in different experiments. Although a zone of slow conduction was identified in seven of the experiments, slow conduction transverse to fiber orientation appeared crucial in maintaining reentry in only three experiments. Multiple reentrant mechanisms of VT may be present in this single canine infarction model. Although a zone of slow conduction is usually present, the characteristics of the region of block are highly variable. However, epicardial reentry accounted for only a minority of induced arrhythmia episodes.
authors.affiliation: Department of Internal Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: N
authors.initials: N
authors.lastname: Kanaan
authors.forename: N
authors.initials: N
authors.lastname: Robinson
authors.forename: S I
authors.initials: SI
authors.lastname: Roth
authors.forename: D
authors.initials: D
authors.lastname: Ye
authors.forename: J
authors.initials: J
authors.lastname: Goldberger
authors.forename: A
authors.initials: A
authors.lastname: Kadish
mesh_terms: D000818:Animals; D018780:Body Surface Potential Mapping; D004285:Dogs; D004562:Electrocardiography; D006329:Heart Conduction System / Q000503:physiopathology; D009203:Myocardial Infarction / Q000150:complications*; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000503:physiopathology; D017180:Tachycardia, Ventricular / Q000473:pathology / Q000503:physiopathology*