Using models to explore whole-body metabolism and accessing models through a model library.
A model is a mathematical representation of a system that can be used to explore the system in a number of ways: to determine the system's internal connections, to calculate properties of the system such as flow rates and pool sizes, and to make predictions about the system's behavior under different conditions. The use of modeling to explore whole-body metabolism is demonstrated using a compartmental model of zinc kinetics as an example. Because models are useful tools for exploring systems, a facility called a "model library" is being established on the Internet to provide access to working versions of published models.
Wastney
M E
ME
Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20007, USA.
Subramanian
K N
KN
Broering
N
N
Boston
R
R
D000818:Animals; D006801:Humans; D007700:Kinetics; D008660:Metabolism; D008954:Models, Biological; D051381:Rats; D013552:Swine; D013997:Time Factors; D015032:Zinc / Q000097:blood / Q000378:metabolism*; D015037:Zinc Radioisotopes
D015037:Zinc Radioisotopes; D015032:Zinc