5-Fluorouracil-induced severe but reversible cardiogenic shock: a case report.
5-fluorouracil cardiotoxicity is increasingly recognized with variable presentation. We report a patient who developed cardiogenic shock due to high-dose 5-fluorouracil infusion (1,000 mg/m2 every 24 hr for 96 hr). There was no evidence of myocardial necrosis. The patient recovered completely without any residual cardiac dysfunction. The exact cause of 5-fluorouracil toxicity remains to be determined. The case highlights the need for careful monitoring of patients who receive high-dose 5-fluorouracil for the development of cardiotoxicity.
Akhtar
S S
SS
Department of Medical Oncology, S.K. Institute of Medical Sciences, Soura Srinagar, Kashmir, India.
Wani
B A
BA
Bano
Z A
ZA
Salim
K P
KP
Handoo
F A
FA
D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D004562:Electrocardiography; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D012770:Shock, Cardiogenic / Q000139:chemically induced* / Q000503:physiopathology
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil