[The dynamics of bone defect healing after the implantation of collagen and hydroxyapatite complexes (an experimental morphological study)].
Healing of standard bone defects in the distal third of the femoral bone was studied in experiments on 48 rats. In order to repair the defect, colapol or a new composition with structurized collagen and hydroxyapatite powder and granulate KP-2 were used. Histological study showed that healing was optimal after repair with KP-2 composition: callus formed rapidly, as did the typical osseogranular complexes. Newly formed bone structures mature much sooner than after implantation of colapol. The authors come to a conclusion that the use of KP-2 composition holds good promise as material for maxillofacial surgery in plastic repair of bone defects.
Grigor'ian
A S
AS
Pulatova
N A
NA
Volozhin
A I
AI
Istranov
L P
LP
D000818:Animals; D018786:Bone Substitutes / Q000627:therapeutic use*; D001842:Bone and Bones / Q000187:drug effects* / Q000473:pathology; D002516:Ceramics / Q000627:therapeutic use; D003094:Collagen / Q000627:therapeutic use*; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D017886:Durapatite / Q000627:therapeutic use*; D005269:Femur / Q000187:drug effects / Q000473:pathology; D051381:Rats; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
D018786:Bone Substitutes; C098475:Colapol; D004338:Drug Combinations; C104009:KP-2 composition; D003094:Collagen; D017886:Durapatite
Dinamika zazhivleniia kostnykh defektov pri implantatsii v nikh kompleksov kollagena i gidroksiapatita (éksperimental'no-morfologicheskoe issledovanie).