Graves' disease associated with exophthalmos, cerebral ventricular dilatation and accelerated growth.
A report is presented of a girl with Graves' disease, which was diagnosed at the age of 1.7 years. The mother had no thyroid disease. The patient developed signs of hyperthyroidism shortly before her first birthday, and the most prominent manifestations were accelerated skeletal maturation and linear growth, and dilatation of the brain ventricles. The latter manifestation, which has not been reported previously, was reversible upon normalisation of thyroid function with antithyroid treatment for three years.
Arisaka
O
O
Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.
Hosaka
A
A
Arai
H
H
Fujiwara
S
S
Tadokoro
R
R
Yabuta
K
K
D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D013956:Antithyroid Agents / Q000627:therapeutic use; D001927:Brain Diseases / Q000150:complications / Q000188:drug therapy; D002552:Cerebral Ventricles; D002675:Child, Preschool; D004108:Dilatation, Pathologic / Q000150:complications / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D006111:Graves Disease / Q000150:complications* / Q000188:drug therapy; D006130:Growth Disorders / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007223:Infant; D008713:Methimazole / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D016896:Treatment Outcome
D000318:Adrenergic beta-Agonists; D013956:Antithyroid Agents; D008713:Methimazole; D011433:Propranolol