Association of body mass index, blood pressure and serum levels of triglycerides and high-density lipoprotein cholesterol in childhood with the insulin sensitivity index in young adulthood: a 13-year follow-up.
BACKGROUND
Tracking of body mass index (BMI), blood pressure and serum lipids from childhood to adulthood has been demonstrated in previous studies. Whether these factors are associated with the insulin-sensitivity index measured in young adulthood (ISIadult) remains undetermined.


OBJECTIVE
To determine whether any association exists between the ISIadult and BMI, blood pressure and plasma lipids measured in childhood (1979).


METHODS
The study included 227 unrelated white subjects (aged 18-32 years). Their ISIadult were measured in 1992/93 with a combined intravenous glucose (0.3 gl/kg body weight) and tolbutamide (3 mg/kg body weight) tolerance test. BMI, blood pressure and blood lipids were measured in 1979 and again in 1992/93.


RESULTS
In men, plasma high-density lipoprotein cholesterol (HDLC) in 1979 (rs = 0.25, F = 0.006) was positively associated with ISIadult and plasma triglyceride measured in 1979 (rs = -0.34, P = 0.001). BMI (rs = -0.29, P = 0.002) and systolic blood pressure, both measured in 1979 (rs = -0.29, P = 0.002) were associated negatively with ISIadult. In women, plasma HDLC measured in 1979 was associated positively and significantly with ISIadult (rs = 0.21, P = 0.024) and BMI measured in 1979 was associated significantly and negatively with ISIadult (rs = -0.22, P = 0.018). Plasma triglyceride or systolic blood pressure, both measured in 1979, were not associated with ISIadult. In gender-stratified multiple-regression analyses [controlling for waist circumference(adult) maximal aerobic capacity (VO2max(adult)), age and women's use of oral contraceptives], plasma HDLC measured in 1979 was associated significantly with ISIadult in men (P = 0.026) but not in women (P = 0.066). A negative association was found between plasma triglyceride measured in 1979 and ISIadult (P = 0.045) in men, but not in women (P = 0.30). BMI, total cholesterol and systolic and diastolic blood pressure, all measured in 1979, were not associated with ISIadult.


CONCLUSIONS
Low plasma HDLC, high plasma triglyceride and high BMI in childhood are associated with low insulin-sensitivity index values in young adulthood.
Clausen
J O
JO
Medical Department C, Glostrup Hospital, University of Copenhagen, Denmark.
Ibsen
H
H
Ibsen
K K
KK
Borch-Johnsen
K
K
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000209:etiology / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin; D007333:Insulin Resistance; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
D007328:Insulin; D008075:Lipoproteins, HDL; D014280:Triglycerides