[Effect of the calcium antagonist amlodipine on non-vascular smooth muscle exemplified by the uterus].
The effect of amlodipine, a recently developed calciumantagonist on 21 uterine strips was investigated. Uterine activity, expressed by the area under the curve was depressed from 504 (51 to 1056) mm2 to 0 (0 to 130) 10 min after the application of amlodipine. After 20 and 60 min, the values were 0 (0 to 1310) and 0 (0 to 317) (median, 10th and 90th percentile). The decrease of uterine activity was highly significant (p < 0.0001). In summary, amlodipine exhibits a prompt and excellent relaxation on the spontaneous contractions of uterine strips.
Lechner
W
W
Universitätsklinik für Frauenheilkunde, Innsbruck.
Bergant
A
A
Sölder
E
E
Kölle
D
D
D017311:Amlodipine / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002585:Cesarean Section; D046508:Culture Techniques; D003864:Depression, Chemical; D005260:Female; D006801:Humans; D009130:Muscle, Smooth / Q000187:drug effects*; D011247:Pregnancy; D014590:Uterine Contraction / Q000187:drug effects*
D002121:Calcium Channel Blockers; D017311:Amlodipine
Die Wirkung des Kalziumantagonisten Amlodipin an nichtvaskulärer, glatter Muskulatur am Beispiel des Uterus.