Chloropeptins, new anti-HIV antibiotics inhibiting gp120-CD4 binding from Streptomyces sp. II. Structure elucidation of chloropeptin I.
The structure of chloropeptin I, a gp120-CD4 binding inhibitor having a potent anti-HIV activity, was elucidated by 1H and 13C NMR experiments and chemical degradation. It is a peptide antibiotic consisting of six aryl amino acids residues and an alpha-oxo aryl acid some of which have chlorine atoms.
Matsuzaki
K
K
School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Ogino
T
T
Sunazuka
T
T
Tanaka
H
H
Omura
S
S
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D019380:Anti-HIV Agents / Q000737:chemistry*; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D002733:Chlorophenols / Q000737:chemistry*; D015699:HIV Envelope Protein gp120 / Q000378:metabolism*; D009842:Oligopeptides / Q000737:chemistry*; D010456:Peptides, Cyclic
D000900:Anti-Bacterial Agents; D019380:Anti-HIV Agents; D002733:Chlorophenols; D015699:HIV Envelope Protein gp120; D009842:Oligopeptides; D010456:Peptides, Cyclic; C090485:chloropeptin I; C023490:complestatin