Propionibacterium acnes in the cortex of patients with Alzheimer's disease.
Propionibacterium acnes was found in the cortex of three patients with Alzheimer's disease and in one frontal cortex of an elderly patient with cardiovascular risk factors and hypoxia due to a large glioblastoma of the right frontal lobe with severely increased intracranial pressure. Propionibacterium acnes is an atypical anaerobic bacterium which is sensitive to cephalosporins, but insensitive to metronidazole. It is concluded that a capillary microangiopathy (in consequence of old age and cardiovascular risk factors such as high blood pressure) leads to cortical hypoxia and reduced resistance of the cortical immune system. Prevention by dietary regimes counteracting microangiopathy and treatment with cephalosporins are recommended.
Kornhuber
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D000368:Aged; D000544:Alzheimer Disease / Q000382:microbiology*; D002540:Cerebral Cortex / Q000382:microbiology*; D006801:Humans; D011425:Propionibacterium acnes / Q000302:isolation & purification*