Effect of sairei-to on prostaglandin E2-induced phosphatidylinositol breakdown in aminonucleoside nephrotic rat.
We describe the effects of Sairei-to, a Chinese herbal medicine, on aminonucleoside-induced nephrotic rats (ANNR), and analyze the urinary excretion of protein and phosphatidylinositol (PI) turnover via prostaglandin E2 (PGE2) receptors in isolated glomeruli. Sairei-to suppressed urinary excretion of protein and PGE2 in ANNR, and inhibited acceleration of PI turnover in isolated nephrotic glomeruli. The affected responsiveness of the PI turnover system to PGE2 in a nephrotic state was presumed to be normalized by Sairei-to. These findings suggest that Sairei-to restores abnormal changes in the PI turnover system in ANNR kidneys, and thereby inhibit excretion of protein into the urine.
Suzuki
J
J
Department of Pediatrics, Fukushima Medical College, Japan.
Watanabe
K
K
Kobayashi
T
T
Yoshida
K
K
Watanabe
Y
Y
Kumada
K
K
Suzuki
S
S
Kume
K
K
Suzuki
H
H
D000818:Animals; D015232:Dinoprostone / Q000652:urine*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism; D008297:Male; D009404:Nephrotic Syndrome / Q000139:chemically induced / Q000188:drug therapy / Q000652:urine; D010716:Phosphatidylinositols / Q000378:metabolism*; D011507:Proteinuria / Q000188:drug therapy / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D018078:Receptors, Prostaglandin E / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D010716:Phosphatidylinositols; D018078:Receptors, Prostaglandin E; C080903:sairei-to; D015232:Dinoprostone