title: The role of cholecystectomy in acquired immunodeficiency syndrome.
abstract: BACKGROUND
  Hepatobiliary disease is a common manifestation of acquired immunodeficiency syndrome, although the role of surgical intervention in the spectrum of therapy is unclear.
  
  
  METHODS
  A retrospective review was designed to evaluate the characteristics of patients given a diagnosis of human immunodeficiency virus infection or acquired immunodeficiency syndrome and undergoing cholecystectomy between January 1, 1986, and November 1, 1995.
  
  
  RESULTS
  The study included 40 patients (35 men, 5 women; mean age, 42 +/- 9 years), 33 (82.5 percent) with acquired immunodeficiency syndrome; their mean preoperative T-helper (CD4) cell count was 163/mL3. Gross pathologic findings included acute (n = 9, 22.5 percent) and chronic (n = 31, 77.5 percent) cholecystitis. Gallbladder specimens were positive for cholelithiasis in 28 (70 percent), Cryptococcus organisms in 5 (12.5 percent), cytomegalovirus in 3 (7.5 percent), and lymphoma in 2 (5 percent). The median follow-up time was 48 months (range, 6 to 63 months). The percentage survival was 92.5 percent (n = 37) at 30 days, and 57.5 percent (n = 23), 37.5 percent (n = 15), and 25 percent (n = 10) at 12, 24, and 36 months, respectively. The mean survival time was 25.1 months. The likelihood of survival was directly linked to the CD4 cell count. The mean survival period was 25 months for patients with CD4 cell counts less than 200/mL3 compared with 48 months for those with CD4 cell counts greater than 200/mL3.
  
  
  CONCLUSIONS
  Although the pathologic changes identified in patients with acquired immunodeficiency syndrome may occasionally be atypical, the clinical presentation, indications for operation, and pathologic findings identified are quite common. Patients tolerate cholecystectomy well with good long-term outcome and minimal infectious complications. Even in patients with the most compromised immune status, a 2-year survival after operation is acceptable. Cholecystectomy has a clear role in the spectrum of treatment for biliary disease relative to acquired immunodeficiency syndrome.
authors.affiliation: Department of Surgery, St. Vincent's Hospital and Medical Center, New York, NY, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Flum
authors.forename: S D
authors.initials: SD
authors.lastname: Steinberg
authors.forename: A Y
authors.initials: AY
authors.lastname: Sarkis
authors.forename: J R
authors.initials: JR
authors.lastname: Pacholka
authors.forename: M K
authors.initials: MK
authors.lastname: Wallack
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology / Q000401:mortality; D000208:Acute Disease; D000328:Adult; D015704:CD4 Antigens; D002763:Cholecystectomy; D002764:Cholecystitis / Q000150:complications* / Q000601:surgery*; D002908:Chronic Disease; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000276:immunology / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors
chemical_list: D015704:CD4 Antigens