title: Gene ordering and localization by linkage analysis.
abstract: This chapter has covered the preparation of pedigree and datafiles suitable for linkage analysis, the calculation of gene frequencies and recombination fractions, the ordering of markers into a genetic map, and the placing of an unknown locus, such as a disease locus or phenotype, onto a fixed map of markers. The chapter has concentrated on the use of the GAS package, but some other programs for linkage analysis have also been mentioned.
authors.affiliation: Biochemistry Department, University of Oxford, UK.
authors.forename: R E
authors.initials: RE
authors.lastname: March
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping; D003195:Computer Communication Networks; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree; D010641:Phenotype; D011995:Recombination, Genetic; D012984:Software; D018709:Statistics, Nonparametric
chemical_list: D005819:Genetic Markers