title: RelB, a member of the Rel/NF-kappa B family of transcription factors.
abstract: RelB, originally identified as an immediate early gene product, is a member of the Rel/NF-kappa B family of transcription factors important for the regulation of genes involved in immune and inflammatory processes. RelB by itself is inactive due to its inability to homodimerize and to bind to kappa B sequences. However, in the presence of the Rel/NF-kappa B proteins p50 or p52, RelB is a potent transactivator. Transcriptional activation domains were identified in the NH2 and COOH termini of RelB separated by the approximately 300 amino acids spanning the Rel homogy domain (RHD). The last 120 amino acids of this domain are necessary for the dimerization of RelB and were analyzed in detail by in vitro mutagenesis. RelB forms complexes with p50 and p52 but not with RelA and c-Rel. In contrast to RelA-containing complexes, RelB-containing complexes are only weakly inhibited in their activity by I kappa B alpha. Furthermore, in lymphoid tissues RelB is not associated with I kappa B alpha. In contrast to other members of the Rel/NF-kappa B family, high expression of RelB is limited to interdigitating dendritic cells. Mice with a targeted disrupted relB locus show phenotypic abnormalities including multifocal, mixed inflammatory cell infiltration in several organs, myeloid hyperplasia, splenomegaly due to extramedullary hematopoiesis, and a reduced population of thymic dendritic cells.
authors.affiliation: Department of Oncology, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA.
authors.forename: R P
authors.initials: RP
authors.lastname: Ryseck
authors.forename: F
authors.initials: F
authors.lastname: Weih
authors.forename: D
authors.initials: D
authors.lastname: Carrasco
authors.forename: R
authors.initials: R
authors.lastname: Bravo
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000502:physiology; D008221:Lymphoid Tissue / Q000502:physiology; D051379:Mice; D016328:NF-kappa B; D011518:Proto-Oncogene Proteins; D051841:Transcription Factor RelB; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology; D015533:Transcriptional Activation
chemical_list: D016328:NF-kappa B; D011518:Proto-Oncogene Proteins; C497594:Relb protein, mouse; D014157:Transcription Factors; D051841:Transcription Factor RelB