title: Teicoplanin concentrations in serum, pericardium, pericardial fluid and thoracic wall fat in patients undergoing cardio-pulmonary bypass surgery.
abstract: The concentrations of teicoplanin in serum, pericardium, pericardial fluid and thoracic wall fat were measured in patients undergoing cardio-pulmonary bypass (CPB) after the administration of a single i.v. 12 mg/kg dose. Five minutes after the start of CPB, teicoplanin serum concentrations decreased by, on average, 35% (95% confidence interval (CI): 28-42%) and remained significantly lower than the expected values over the subsequent 60 min period. After aortic unclamping drug concentrations rebounded but remained significantly lower than the expected values in the next 60 min. Immediately before CPB, penetration of teicoplanin in pericardium and thoracic wall fat was 0.44 (95% CI: 0.23-0.65) and 0.05 (95% CI: 0.03-0.7), respectively, and increased at the end of CPB to 0.90 (95% CI: 0.55-1.25) and 0.17 (95% CI: 0.05-0.29), respectively. MICs for most staphylococcal strains were attained during CPB procedure in pericardium but not in thoracic wall fat. However, since staphylococcal infections involve the interstitial space it is likely that penetration into fat cells is not important for antimicrobial prophylaxis. In this respect, it is worth noting that drug concentration in pericardial fluid, which should reflect the interstitial concentration, was higher than the MIC for most staphylococcal strains. Although no infective complications were observed in our limited series of patients, larger clinical trials are needed to assess whether the dose regimen employed is effective in preventing post-CPB surgery infections.
authors.affiliation: Department of Pharmacology, University of Padova, Italy.
authors.forename: P A
authors.initials: PA
authors.lastname: Miglioli
authors.forename: F
authors.initials: F
authors.lastname: Merlo
authors.forename: A
authors.initials: A
authors.lastname: Fabbri
authors.forename: R
authors.initials: R
authors.lastname: Padrini
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000368:Aged; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D002315:Cardiopulmonary Bypass; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010490:Pericardial Effusion / Q000378:metabolism*; D010496:Pericardium / Q000378:metabolism*; D017334:Teicoplanin / Q000493:pharmacokinetics*; D013909:Thorax
chemical_list: D000900:Anti-Bacterial Agents; D017334:Teicoplanin