Metabolism and bioaccumulation of fenvalerate and its metabolites in rat organs.
Metabolism and bioaccumulation of fenvalerate and its fenvalerate its metabolites in liver, kidney and brain of rat following the oral administration of a sub-lethal dose (15 mg/kg) of the pesticide for 7, 15 and 30 day periods was investigated by high-performance liquid chromatography (HPLC) in terms of the relative mole concentrations in rat tissues. The cleavage of the ester linkage in fenvalerate yielding two metabolites was found to be primary step in the biodegradation of fenvalerate in rat organs. These metabolites were purified to homogeneity by HPLC and characterized by infra-red spectroscopy as 4-chloro-alpha-(1-methylethyl) benzeneacetic acid and 3-phenoxy benzoic acid.
Misra
S
S
Department of Biosciences and Biotechnology, University of Roorkee, India.
Sharma
C B
CB
D000818:Animals; D001921:Brain / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D007306:Insecticides; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D009570:Nitriles; D011722:Pyrethrins / Q000378:metabolism* / Q000493:pharmacokinetics*; D051381:Rats; D013055:Spectrophotometry, Infrared
D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017690:fenvalerate