title: Potential antitumor agents. 25 [1]. Synthesis and cytotoxic activity of 3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones.
abstract: The Knoevenagel reaction between 2-indolinones and 2-chloroindolaldehydes gave 3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones which were tested as potential antitumor agents on cultures of HeLa cells. 2-Chloro derivatives with at least one unsubstituted NH group, are promising candidates for further investigation.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Bologna, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Andreani
authors.forename: A
authors.initials: A
authors.lastname: Locatelli
authors.forename: M
authors.initials: M
authors.lastname: Rambaldi
authors.forename: A
authors.initials: A
authors.lastname: Leoni
authors.forename: R
authors.initials: R
authors.lastname: Bossa
authors.forename: A
authors.initials: A
authors.lastname: Fraccari
authors.forename: I
authors.initials: I
authors.lastname: Galatulas
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis*
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles