Muramyl-dipeptide-induced fever in cats.
The characteristics of fever induced by intravenous injection of muramyl dipeptide (MDP; 25 micrograms/kg) were studied in cats implanted with electrodes for chronic recording of electromyograms, brain temperature (Tb) and subcutaneous temperature. Intravenous injection of MDP was followed by a bimodal fever response after a latent period of 19.4 +/- 1.3 min. Maximum Tb was reached 62.0 +/- 20.7 min after injection, with a second minor peak at about 4 h following injection. Tb returned to baseline after 6-8 h. A single intravenous injection of MDP induced a stable reproducible thermal response which allowed to study the properties of body temperature and effector mechanisms during fever in cats.
Amini-Sereshki-Kormi
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Department of Biology, Worchester State College, MA 01602, USA.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002415:Cats; D004569:Electroencephalography / Q000187:drug effects; D005334:Fever / Q000139:chemically induced / Q000503:physiopathology*; D007275:Injections, Intravenous
D000119:Acetylmuramyl-Alanyl-Isoglutamine