Gene ordering and localization by linkage analysis.
This chapter has covered the preparation of pedigree and datafiles suitable for linkage analysis, the calculation of gene frequencies and recombination fractions, the ordering of markers into a genetic map, and the placing of an unknown locus, such as a disease locus or phenotype, onto a fixed map of markers. The chapter has concentrated on the use of the GAS package, but some other programs for linkage analysis have also been mentioned.
March
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Biochemistry Department, University of Oxford, UK.
D000483:Alleles; D002874:Chromosome Mapping; D003195:Computer Communication Networks; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree; D010641:Phenotype; D011995:Recombination, Genetic; D012984:Software; D018709:Statistics, Nonparametric
D005819:Genetic Markers