The anxiolytic-like effect of metabotropic glutamate receptor antagonists after intrahippocampal injection in rats.
Using the conflict drinking Vogel test in rats as a model we examined the anxiolytic-like activity, after their intrahippocampal administration of (S)-4-carboxy-3-hydroxyphenyl-glycine (S-4C3H-PG), RS-alpha-methylserine-O-phosphate-monophenyl ester (MSOPPE) and (RS)-alpha-methylserine-O-phosphate (MSOP), the antagonists of the I, the II and the III group of metabotropic glutamate receptors (mGlu receptors), respectively. The results indicate that S-4C3H-PG and MSOP produced a dose-dependent anticonflict effect in rats, which was unrelated to a reduced perception of the stimulus or to an increased thirst drive. The hippocampus may be one of the neuroanatomical sites of the anxiolytic-like effects of both mGlu receptor antagonists.
Chojnacka-Wójcik
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E
Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland.
Tatarczyńska
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E
Pilc
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A
D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003220:Conflict, Psychological; D004326:Drinking / Q000187:drug effects; D004327:Drinking Behavior / Q000187:drug effects; D004597:Electroshock; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D006624:Hippocampus / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D007267:Injections; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors*
D014151:Anti-Anxiety Agents; D018691:Excitatory Amino Acid Antagonists; D018094:Receptors, Metabotropic Glutamate