Potential antitumor agents. 25 [1]. Synthesis and cytotoxic activity of 3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones.
The Knoevenagel reaction between 2-indolinones and 2-chloroindolaldehydes gave 3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones which were tested as potential antitumor agents on cultures of HeLa cells. 2-Chloro derivatives with at least one unsubstituted NH group, are promising candidates for further investigation.
Andreani
A
A
Dipartimento di Scienze Farmaceutiche, Università di Bologna, Italy.
Locatelli
A
A
Rambaldi
M
M
Leoni
A
A
Bossa
R
R
Fraccari
A
A
Galatulas
I
I
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis*
D000970:Antineoplastic Agents; D007211:Indoles