title: Oral squamous cell carcinoma following treatment of acute lymphoblastic leukaemia.
abstract: With substantially increased survival after most paediatric cancers over the past decades have come the late sequelae of treatment. Of all late complications of treatment, second malignancies are generally considered to be the most serious. We report on a 20-year-old man with an oral squamous cell carcinoma 17 years after initial chemotherapy and irradiation for acute lymphoblastic leukaemia. Although occurrence of the oral malignancy in this patient could have been treatment-related, one should keep in mind that the occurrence of second tumours may also be based on a shared genetic aetiology.
authors.affiliation: Department of Oral & Maxillofacial Surgery/Oral Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.
authors.forename: R I
authors.initials: RI
authors.lastname: van der Waal
authors.forename: A J
authors.initials: AJ
authors.lastname: Veerman
authors.forename: G B
authors.initials: GB
authors.lastname: Snow
authors.forename: I
authors.initials: I
authors.lastname: van der Waal
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D016371:Cranial Irradiation; D017809:Fatal Outcome; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009062:Mouth Neoplasms / Q000473:pathology* / Q000601:surgery; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local; D016609:Neoplasms, Second Primary / Q000473:pathology* / Q000601:surgery; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000532:radiotherapy; D012074:Remission Induction