[Medicamentous therapy of alcoholic polyneuropathy. Randomized double-blind study comparing 2 vitamin B preparations and a nucleotide preparation].
In a randomized double-blind study involving 303 patients with alcoholic polyneuropathy the efficacy and tolerability of the combinations thiamine/pyridoxine, benfotiamine/pyridoxine, and the nucleotides of cytidine and uridine administered orally for 21 days were compared. Pain and paraesthesia, measured on a visual 10-cm-long analogue scale, as also pallaesthesia and the strength of the dorsiflexion and plantar flexors of the foot, clearly improved in all treatment groups. Clinically relevant differences in efficacy were not observed. All the drugs tested were well tolerated.
Kretschmar
C
C
III. Psychiatrische Klinik, Klinik für Suchtkrankheiten, Schwerin.
Kaumeier
S
S
Haase
W
W
D000328:Adult; D000437:Alcoholism / Q000150:complications* / Q000534:rehabilitation; D003562:Cytidine / Q000008:administration & dosage*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy*; D011736:Pyridoxine / Q000008:administration & dosage*; D013831:Thiamine / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D016896:Treatment Outcome; D014529:Uridine / Q000008:administration & dosage*
D003562:Cytidine; D011736:Pyridoxine; D014529:Uridine; D013831:Thiamine; C013835:benphothiamine
Die medikamentöse Therapie der alkoholischen Polyneuropathie. Randomisierte Doppelblindstudie zum Vergleich zweier Vitamin-B-Präparate und eines Nukleotid-Präparates.