Cerebral vasculitis associated with acute post-streptococcal glomerulonephritis.
The following is a case study involving a 13-year-old girl who presented initial symptoms of an upper respiratory infection. One week later she experienced a short seizure and hours later a grand mal seizure. MRI examination of the brain demonstrated multiple changing abnormal foci of increased density in white and gray matter suggestive of a vasculitic inflammatory pattern. As a result of proteinuria and red cell casts on urinalysis, a renal biopsy was performed resulting in a diagnosis of acute post-streptococcal glomerulonephritis (APSGN). We concluded on the basis of the MRI that vasculitis was secondary to APSGN. The following paper is a description of our findings in this case and a review of the literature supporting this new interpretation of CNS disease due to APSGN.
Rovang
R D
RD
Department of Internal Medicine, University of South Dakota School of Medicine, Sioux Falls 57105, USA.
Zawada
E T
ET
Santella
R N
RN
Jaqua
R A
RA
Boice
J L
JL
Welter
R L
RL
D000208:Acute Disease; D000293:Adolescent; D001706:Biopsy; D001921:Brain / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000209:etiology*; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008854:Microscopy, Electron; D012141:Respiratory Tract Infections / Q000150:complications; D013290:Streptococcal Infections / Q000150:complications*; D014657:Vasculitis / Q000209:etiology*