The prophylactic effects of superoxide dismutase, catalase, desferrioxamine, verapamil and disulfiram in experimental colitis.
In our study we have tried to compare the prophylactic effects of superoxide dismutase (SOD), SOD+catalase (CAT), desferrioxamine, verapamil and disulfiram, which are all free oxygen radical (FOR) scavengers, in an animal model of experimental acetic acid colitis. The control group had 58.3% colonic ulcers. The SOD group (48.6% ulcerated area) and the SOD+CAT group (47.2% ulcerated area) did not show a significant difference when compared with the control group. The values were significantly different in all other groups when compared with the control group (desferrioxamine (29.2% ulcerated area): P < 0.01; verapamil (10.4% ulcerated area) and disulfiram (7.6% ulcerated area): P < 0.001. In conclusion, desferrioxamine, verapamil and disulfiram have been found to be effective as prophylactics in experimental acetic acid colitis.
Köksoy
F N
FN
Department of Surgery, Istanbul Taksim Hospital, Istanbul Medical School, Turkey.
Köse
H
H
Soybír
G R
GR
Yalçin
O
O
Cokneşelí
B
B
D019342:Acetic Acid / Q000009:adverse effects; D000818:Animals; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002374:Catalase / Q000627:therapeutic use*; D003092:Colitis / Q000517:prevention & control*; D003108:Colonic Diseases / Q000517:prevention & control; D003676:Deferoxamine / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004221:Disulfiram / Q000627:therapeutic use*; D016166:Free Radical Scavengers / Q000627:therapeutic use; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D017382:Reactive Oxygen Species; D017262:Siderophores / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000627:therapeutic use; D014456:Ulcer / Q000517:prevention & control; D014700:Verapamil / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D016166:Free Radical Scavengers; D005765:Gastrointestinal Agents; D017382:Reactive Oxygen Species; D017262:Siderophores; D014700:Verapamil; D002374:Catalase; D013482:Superoxide Dismutase; D003676:Deferoxamine; D019342:Acetic Acid; D004221:Disulfiram