title: p53 mutations in two patients with intraductal papillary adenoma of the pancreas.
abstract: There has been no report on p53 gene mutation in benign human pancreatic intraductal tumors. We examined pancreatic juice and tissue specimens from two patients with intraductal papillary adenoma of the pancreas by polymerase chain reaction-single-strand conformation polymorphism analysis and direct sequencing and found point mutations of p53 gene resulting in amino acid substitutions in exons 6 and 8. Thus, p53 gene mutation may be an early event in the neoplastic process of some pancreatic intraductal tumors and may play an important role in tumorigenesis.
authors.affiliation: First Department of Internal Medicine, Yamaguchi University School of Medicine, Ube.
authors.forename: M
authors.initials: M
authors.lastname: Kaino
authors.forename: S
authors.initials: S
authors.lastname: Kondoh
authors.forename: S
authors.initials: S
authors.lastname: Okita
authors.forename: S
authors.initials: S
authors.lastname: Ryozawa
authors.forename: S
authors.initials: S
authors.lastname: Hatano
authors.forename: K
authors.initials: K
authors.lastname: Shiraishi
authors.forename: S
authors.initials: S
authors.lastname: Kaino
authors.forename: T
authors.initials: T
authors.lastname: Akiyama
authors.forename: K
authors.initials: K
authors.lastname: Okita
authors.forename: T
authors.initials: T
authors.lastname: Kawano
mesh_terms: D000236:Adenoma / Q000235:genetics*; D004247:DNA / Q000737:chemistry; D006801:Humans; D016296:Mutagenesis; D010190:Pancreatic Neoplasms / Q000235:genetics*; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D016159:Tumor Suppressor Protein p53; D004247:DNA