Yeast aldehyde dehydrogenase sensitivity to inhibition by chlorpropamide analogues as an indicator of human aldehyde dehydrogenase sensitivity to these agents.
Devaraj
V R
VR
Department of Pharmacology, University of Minnesota, Minneapolis 55455, USA.
Sreerama
L
L
Lee
M J
MJ
Nagasawa
H T
HT
Sladek
N E
NE
D000230:Adenocarcinoma / Q000201:enzymology; D000444:Aldehyde Dehydrogenase / Q000037:antagonists & inhibitors*; D000080924:Aldehyde Dehydrogenase 1 Family; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D001943:Breast Neoplasms / Q000201:enzymology; D002747:Chlorpropamide / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004926:Escherichia coli; D005260:Female; D005753:Gastric Mucosa / Q000201:enzymology; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D007700:Kinetics; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D050697:Retinal Dehydrogenase; D012441:Saccharomyces cerevisiae / Q000201:enzymology*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D014407:Tumor Cells, Cultured
D004791:Enzyme Inhibitors; D007527:Isoenzymes; D011994:Recombinant Proteins; C030863:corneal protein 54, bovine; D000080924:Aldehyde Dehydrogenase 1 Family; C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial; C510223:ALDH1A1 protein, human; D050697:Retinal Dehydrogenase; D002747:Chlorpropamide