[The hypotensive action and side effects of the carboanhydrase inhibitor dorzolamide hydrochloride].
Effects of a carboanhydrase inhibitor 2% dorsolamine hydrochloride solution (Trusopt) on intraocular pressure and some ocular functions have been studied in patients with primary open-angle glaucoma (POAG): 10 patients aged 56 to 72 (16 eyes) with POAG and 5 patients aged 60 to 68 (8 eyes) with normal ophthalmic tone administered a single instillation of Trusopt and 15 subjects aged 63 to 82 (21 eyes) with POAG to whom Trusopt was administered three times daily for 14 days. A single instillation of the drug resulted in a reliable decrease of intraocular pressure both in glaucoma patients and subjects with normal ophthalmic tone. Maximal lowering of intraocular pressure was recorded 2 hours after instillation, by 21.4% of initial, on average. The hypotensive effect persisted for 12 hours (8.9% reduction of intraocular pressure). 80% of examinees complained of a sensation of short-term burning in the eye directly after instillation. Prolonged use of Trusopt was associated with a tendency to boosting the hypotensive effect: after 12 hours intraocular pressure was 15.4% lower than initially. Tonography showed a reliable (18.5%) reduction of aqueous humor production.
Egorov
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D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002257:Carbonic Anhydrase Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D004341:Drug Evaluation; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D013449:Sulfonamides / Q000008:administration & dosage* / Q000009:adverse effects; D013876:Thiophenes / Q000008:administration & dosage* / Q000009:adverse effects; D013997:Time Factors; D014065:Tonometry, Ocular
D000959:Antihypertensive Agents; D002257:Carbonic Anhydrase Inhibitors; D009883:Ophthalmic Solutions; D013449:Sulfonamides; D013876:Thiophenes; C062765:dorzolamide
Izuchenie gipotenzivnogo deĭstviia i pobochnykh éffektov ingibitora karboangidrazy dorzolamida gidrokhlorida.