title: Nucleotide sequence of the herpes simplex virus type 2 gene encoding the protease and capsid protein ICP35.
abstract: The complete nucleotide sequence of the gene encoding the protease and ICP35 capsid protein of herpes simplex virus (HSV) type 2 strain G has been determined. The gene consisits of a 1908 bp open reading frame capable of encoding 636 amino acids. Comparative nucleotide sequence analysis of the gene with published HSV-1 sequences revealed that the HSV-2 nucleic acid segment most likely encodes two distinct proteins. The first protein is the HSV-2 protease, which is required for the assembly of the herpes virus capsid. The second protein has been previously designated as ICP35 in HSV-1, and belongs to the family of herpesvirus capsid proteins.
authors.affiliation: Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL 60064, USA.
authors.forename: K R
authors.initials: KR
authors.lastname: Steffy
authors.forename: S
authors.initials: S
authors.lastname: Schoen
authors.forename: C M
authors.initials: CM
authors.lastname: Chen
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D004279:DNA, Viral; D010450:Endopeptidases / Q000235:genetics*; D005814:Genes, Viral; D018258:Herpesvirus 2, Human / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D014764:Viral Proteins / Q000235:genetics*
chemical_list: D004279:DNA, Viral; D014764:Viral Proteins; C056094:herpes simplex virus type 2 protein ICP35; D010450:Endopeptidases