title: Structural motifs of the PKD1 protein.
abstract: The complete sequence of the polycystic kidney disease gene (PKD1) and its transcript have been described. The predicted protein is not a member of a previously described gene family, but contains several structural motifs that are present in proteins of known function. Most of these domains are present in the extracellular parts of proteins involved in interactions with other proteins and carbohydrates. The PKD1 gene product also contains potential transmembrane sequences. The molecule is likely to be involved in cell-cell or cell-matrix interactions, which is consistent with the different manifestations of polycystic kidney disease.
authors.affiliation: Imperial Cancer Research Fund., London, UK.
authors.forename: C
authors.initials: C
authors.lastname: Löhning
authors.forename: M
authors.initials: M
authors.lastname: Pohlschmidt
authors.forename: M A
authors.initials: MA
authors.lastname: Glücksmann-Kuis
authors.forename: G
authors.initials: G
authors.lastname: Duyk
authors.forename: P
authors.initials: P
authors.lastname: Bork
authors.forename: M O
authors.initials: MO
authors.lastname: Schneider
authors.forename: S T
authors.initials: ST
authors.lastname: Reeders
authors.forename: A M
authors.initials: AM
authors.lastname: Frischauf
mesh_terms: D005796:Genes; D006801:Humans; D016891:Polycystic Kidney, Autosomal Dominant / Q000235:genetics; D011506:Proteins / Q000235:genetics* / Q000502:physiology; D013329:Structure-Activity Relationship; D050396:TRPP Cation Channels
chemical_list: D011506:Proteins; D050396:TRPP Cation Channels