title: Pathological association and dissociation of functional systems in multiple sclerosis and Huntington's disease.
abstract: This study examined pathological associations and dissociations of functional cognitive systems in patients with multiple sclerosis and Huntington's disease. Using the subtests of the WAIS-R, two motor tests, and the word fluency test, the interest correlations showed distinct patterns. In comparison to normals, the two clinical groups exhibited a greater degree of association among the tests. Subsequently, word fluency performance was predicted from these tests. For the normals, the overall predictive power was quite low (7%). For the MS group, the predictive power rose to 28%. For the HD group, the predictive power was 50%. These results suggest that pathological association of functional systems may be a marker of brain dysfunction and that the affected systems may be delineated by these methods.
authors.affiliation: Department of Psychiatry, University of British Columbia, Canada.
authors.forename: C M
authors.initials: CM
authors.lastname: Clark
authors.forename: C
authors.initials: C
authors.lastname: Jacova
authors.forename: H
authors.initials: H
authors.lastname: Klonoff
authors.forename: B
authors.initials: B
authors.lastname: Kremer
authors.forename: M
authors.initials: M
authors.lastname: Hayden
authors.forename: D
authors.initials: D
authors.lastname: Paty
mesh_terms: D000328:Adult; D003071:Cognition / Q000502:physiology*; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000503:physiopathology* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000503:physiopathology* / Q000523:psychology; D011569:Psychiatric Status Rating Scales