title: Mechanical characteristics of dilated polytetraflouroethylene used for transluminally placed endovascular grafts.
abstract: This study was conducted to assess the mechanical characteristics of dilated polytetraflouroethylene (PTFE) for use in transluminally placed endovascular grafts (TPEGs). Ten-centimeter lengths of 3- and 4-mm thinwalled PTFE were dilated to 8, 10, 12, and 15 mm diameters (3 mm) and 10-, 14-, 16-, and 20-mm diameters (4 mm), respectively (n = 6 for each size). The dilated PTFE segments were evaluated for leakage, further dilation, structural changes (with electron microscopy), and changes in wall thickness occurring after 24 hours of perfusion at pressures of 300-350 mmHg. Both 3- and 4-mm thinwalled PTFE could be dilated to five times their initial diameter before rupture occurred. Three-millimeter grafts dilated to 12- and 4-mm grafts dilated to 14 mm remained resistant to leakage at perfusion pressures up to 350 mmHg. When 3-mm grafts were dilated to 15 mm, the PTFE leaked saline at a rate of 20.3 +/- 9.3 cc per hour at 300 mmHg. pressure. Four-millimeter grafts dilated to 16- and 20-mm diameters leaked saline at 8.4 +/- 7.8 and 52.8 +/- 22 cc per minute, respectively, at the same pressure. No grafts were found to increase in diameter after 24 hours of pressure perfusion. Electron microscopy revealed that PTFE node size was significantly smaller in dilated grafts than in undilated grafts, but there was no significant change in internodal distance. This data suggests that thinwalled PTFE can be dilated to large diameters and retain sufficient strength to resist supraphysiologic pressures. Long-term studies are needed to determine the late structural integrity of dilated PTFE.
authors.affiliation: Department of Surgery, University of North Carolina School of Medicine, Chapel Hill 27599-7212, USA.
authors.forename: W A
authors.initials: WA
authors.lastname: Marston
authors.forename: G L
authors.initials: GL
authors.lastname: Risley
authors.forename: E
authors.initials: E
authors.lastname: Criado
authors.forename: P
authors.initials: P
authors.lastname: McHugh
authors.forename: R L
authors.initials: RL
authors.lastname: Reddick
authors.forename: J T
authors.initials: JT
authors.lastname: Woosley
authors.forename: B A
authors.initials: BA
authors.lastname: Keagy
mesh_terms: D001807:Blood Vessel Prosthesis; D002404:Catheterization; D006801:Humans; D008855:Microscopy, Electron, Scanning; D010477:Perfusion; D011138:Polytetrafluoroethylene; D011475:Prosthesis Failure; D013314:Stress, Mechanical; D013997:Time Factors
chemical_list: D011138:Polytetrafluoroethylene