title: Promoting effect of unilateral nephrectomy on urinary bladder carcinogenesis in rats.
abstract: The effect of unilateral nephrectomy on the growth of bladder tumors was investigated in male F344 rats treated with 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine(BBN) for 6 weeks by means of macroscopical and microscopical examinations. Unilateral nephrectomy 4 weeks after the initiation of BBN administration significantly increased both the number and the volume of visible tumors per rat as compared with the sham-operated group. Histological examination also revealed that the numbers of papillonodular hyperplasia and cancer per basement membrane were significantly increased by unilateral nephrectomy. The results imply a growth-enhancing effect of unilateral nephrectomy on carcinogenesis of the rat bladder.
authors.affiliation: Department of Urology, Fukui Medical School, Matsuoka.
authors.forename: S
authors.initials: S
authors.lastname: Saikawa
authors.forename: H
authors.initials: H
authors.lastname: Kanamaru
authors.forename: B
authors.initials: B
authors.lastname: Li
authors.forename: S
authors.initials: S
authors.lastname: Matsukawa
authors.forename: K
authors.initials: K
authors.lastname: Okada
mesh_terms: D000818:Animals; D002085:Butylhydroxybutylnitrosamine / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D003043:Cocarcinogenesis; D004326:Drinking / Q000187:drug effects; D008297:Male; D009392:Nephrectomy / Q000009:adverse effects*; D051381:Rats; D011916:Rats, Inbred F344; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology
chemical_list: D002273:Carcinogens; D002085:Butylhydroxybutylnitrosamine