title: HPV-16-positive anal and penile carcinomas in a young man--anogenital 'field effect' in the immunosuppressed male?
abstract: This report presents the unusual occurrence of metachronous perianal and penile carcinomas in a young, immunosuppressed man. Both anogenital cancers were HPV-16-DNA-positive by the polymerase chain reaction. DNA in situ hybridization analysis of the penile carcinoma revealed HPV-16 in most neoplastic cells. HPV-16 appears to have played a central role in both anogenital cancers in this patient, suggesting that, like in immunologically susceptible women, a carcinogenic 'field effect' may exist in the anogenital area of the immunosuppressed male.
authors.affiliation: Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Seruminstitut, Copenhagen, Denmark.
authors.forename: M
authors.initials: M
authors.lastname: Frisch
authors.forename: A J
authors.initials: AJ
authors.lastname: van den Brule
authors.forename: N M
authors.initials: NM
authors.lastname: Jiwa
authors.forename: C J
authors.initials: CJ
authors.lastname: Meijer
authors.forename: M
authors.initials: M
authors.lastname: Melbye
mesh_terms: D000328:Adult; D001005:Anus Neoplasms / Q000276:immunology / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000473:pathology*; D003131:Combined Modality Therapy; D006801:Humans; D016867:Immunocompromised Host; D008223:Lymphoma / Q000188:drug therapy / Q000532:radiotherapy; D008297:Male; D016609:Neoplasms, Second Primary / Q000276:immunology / Q000473:pathology*; D010412:Penile Neoplasms / Q000276:immunology / Q000473:pathology*