title: Mib-1 evaluated proliferative activity in ovarian cancer with respect to prognostic significance.
abstract: In the present study, tumor tissue of 251 patients with ovarian cancer was immunohistochemically analysed for proliferative activity using the monoclonal antibody mib-1 and the analyse system CAS 200. The rate of the growth fraction varied from 0% to 71% mib-1 positive tumor cells with a median of 17%. There was a strongly significant association between proliferative activity and the degree of histological differentiation (p = 0.0005), whereas there was no significant correlation with tumor stage and histological subtypes. Using the median as the cut-off point, patients with higher proliferating tumors (> or = 17%) had a statistically significant worse prognosis (p = 0.0431). Especially in the group of patients with grade 1 and grade 2 tumors, measurement of the proliferative activity is of help for prediction of the postoperative survival time of patients (p = 0.0336), suggesting that measurement of the growth fraction estimated by mib-1 reflects more closely the degree of tumor differentiation. However, multivariate analyses cannot confirm these results.
authors.affiliation: Department of Pathology, University of Göttingen, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Marx
authors.forename: H
authors.initials: H
authors.lastname: Meden
authors.forename: T
authors.initials: T
authors.lastname: Brune
authors.forename: M
authors.initials: M
authors.lastname: Kron
authors.forename: M
authors.initials: M
authors.lastname: Korabiowska
authors.forename: W
authors.initials: W
authors.lastname: Kuhn
authors.forename: A
authors.initials: A
authors.lastname: Schauer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D034961:Antigens, Nuclear; D002455:Cell Division / Q000276:immunology; D000939:Epitopes; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen; D008875:Middle Aged; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000032:analysis*; D010051:Ovarian Neoplasms / Q000276:immunology / Q000473:pathology*; D015996:Survival Rate
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D034961:Antigens, Nuclear; D000939:Epitopes; D019394:Ki-67 Antigen; D009687:Nuclear Proteins