title: Alanylglutamine-enriched total parenteral nutrition improves protein metabolism more than branched chain amino acid-enriched total parenteral nutrition in protracted peritonitis.
abstract: Branched chain amino acids (BCAAs) and glutamine are both recommended in catabolic states. The object of this study was to compare the efficacies of alanylglutamine (Ala-Gln)-enriched and BCAA-enriched total parenteral nutrition (TPN) on the protein kinetics in peritonitis. Rats were divided into Ala-Gln and BCAA groups after intraperitoneal implantation of an osmotic pump, delivering a continuous infusion of Escherichia coli. Glutamine composed 30.0% (w/v) of the total amino acids in the Ala-Gln group, and BCAA composed 30.5% (w/v) of the total amino acids in the BCAA group. The two solutions were isocaloric and isonitrogenous. Whole body protein turnover and organ fractional protein synthetic rates (FSR) were measured on days 3 and 5. Serum amino acid levels and mucosal morphology were determined. Ala-Gln group had higher rates of whole body protein turnover, and hepatic FSR on both days. Serum glutamine levels correlated with hepatic and muscle FSR. Ala-Gln TPN group had greater mucosal thickness, numbers of mitoses per crypt, and FSR in distal intestine. Ala-Gln-enriched TPN may be a useful nutritional treatment modality in sepsis.
authors.affiliation: Department of Surgery, The University of Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Naka
authors.forename: H
authors.initials: H
authors.lastname: Saito
authors.forename: Y
authors.initials: Y
authors.lastname: Hashiguchi
authors.forename: M T
authors.initials: MT
authors.lastname: Lin
authors.forename: S
authors.initials: S
authors.lastname: Furukawa
authors.forename: T
authors.initials: T
authors.lastname: Inaba
authors.forename: R
authors.initials: R
authors.lastname: Fukushima
authors.forename: N
authors.initials: N
authors.lastname: Wada
authors.forename: T
authors.initials: T
authors.lastname: Muto
mesh_terms: D000596:Amino Acids / Q000097:blood; D000597:Amino Acids, Branched-Chain / Q000627:therapeutic use*; D000818:Animals; D004151:Dipeptides / Q000627:therapeutic use*; D004195:Disease Models, Animal; D008297:Male; D010289:Parenteral Nutrition, Total / Q000379:methods*; D010538:Peritonitis / Q000097:blood / Q000378:metabolism* / Q000628:therapy*; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000596:Amino Acids; D000597:Amino Acids, Branched-Chain; D004151:Dipeptides; D011506:Proteins; C054122:alanylglutamine