title: Is there a gain from "chance-corrected" measures of diagnostic validity?
abstract: Several authors have proposed alternatives to sensitivity and specificity which they recommend as so-called "chance-corrected" versions of these parameters of diagnostic validity. We argue that these new measures have some undesirable properties in comparison with the established measures and no substantial advantages. In particular, the extension of this concept to chance-corrected ROC curves is shown to be less useful than classical ROC analysis.
authors.affiliation: GSF-Forschungszentrum für Umwelt und Gesundheit, Neuherberg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Holle
authors.forename: J
authors.initials: J
authors.lastname: Windeler
mesh_terms: D003933:Diagnosis; D005069:Evaluation Studies as Topic; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity