Design and synthesis of substrate-derived n-acylaminoalkyl 2-pyridyl disulphides as probes of cysteine proteinase mechanism.
Brocklehurst
K
K
Dept. of Biochemistry, Queen Mary and Westfield College, University of London, UK.
Thomas
E W
EW
Verma
C
C
Patel
M
M
Sreedharan
S K
SK
D001665:Binding Sites; D003545:Cysteine; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D004220:Disulfides / Q000138:chemical synthesis / Q000494:pharmacology*; D015195:Drug Design; D006639:Histidine; D006860:Hydrogen Bonding; D008956:Models, Chemical; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology*; D055672:Static Electricity; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D004220:Disulfides; D011725:Pyridines; D006639:Histidine; D003546:Cysteine Endopeptidases; D003545:Cysteine