7,8-Dihydroneopterin upregulates interferon-gamma promoter in T cells.
Activated cell-mediated immunity is accompanied by elevated concentrations of interferon-gamma leading to the secretion of neopterin-derivatives which are known as sensitive immune activation markers in clinical laboratory diagnosis. Recent data imply a potential role of neopterin-derivatives in oxygen-free radical-mediated processes and a direct impact of 7,8-dihydroneopterin on tumor necrosis factor alpha-mediated programmed cell death. We report here that 7,8-dihydroneopterin and hydrogen peroxide upregulate the production of interferon-gamma, thereby establishing an autocrine feed-back loop. Data put emphasis on the role of neopterin-derivates within the cytokine network.
Baier-Bitterlich
G
G
Institute for Medical Chemistry and Biochemistry, University of Innsbruck, Austria.
Fuchs
D
D
Wachter
H
H
D000975:Antioxidants / Q000494:pharmacology*; D005609:Free Radicals / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D007371:Interferon-gamma / Q000187:drug effects* / Q000235:genetics; D019169:Jurkat Cells; D019798:Neopterin / Q000031:analogs & derivatives; D011401:Promoter Regions, Genetic / Q000187:drug effects*; D011621:Pteridines / Q000494:pharmacology*; D013481:Superoxides / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D015854:Up-Regulation / Q000187:drug effects* / Q000235:genetics
D000975:Antioxidants; D005609:Free Radicals; D011621:Pteridines; D013481:Superoxides; C000976:7,8-dihydroneopterin; D019798:Neopterin; D007371:Interferon-gamma