title: [A patient with an unexplained low level of high density lipoprotein cholesterol].
abstract: A non smoking male patient 42 years old complained of pain in the calves after exercise and had a low 'high density'-lipoprotein (HDL) cholesterol serum concentration. Angiography of the leg vessels revealed no abnormalities. Treatment with simvastatin and gemfibrozil did not affect HDL cholesterol concentrations. Blood tests of relatives made familial hypo-alpha-lipoproteinaemia unlikely. It appeared that the patient had used anabolic steroids; these increase hepatic lipase activity leading to a higher metabolism of HDL and reduced HDL cholesterol levels.
authors.affiliation: Afd. Interne Geneeskunde, St. Antonius Ziekenhuis, Nieuwegein.
authors.forename: M
authors.initials: M
authors.lastname: Castro Cabezas
authors.forename: D
authors.initials: D
authors.lastname: van Loon
authors.forename: H J
authors.initials: HJ
authors.lastname: de Hiep
authors.forename: O J
authors.initials: OJ
authors.lastname: Meuwissen
mesh_terms: D000328:Adult; D045930:Anabolic Agents / Q000009:adverse effects / Q000494:pharmacology*; D008076:Cholesterol, HDL / Q000097:blood* / Q000378:metabolism; D006801:Humans; D007009:Hypolipoproteinemias / Q000097:blood* / Q000235:genetics; D008049:Lipase / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008297:Male; D010375:Pedigree
chemical_list: D045930:Anabolic Agents; D008076:Cholesterol, HDL; D008049:Lipase
vernacular_title: Een patiënt met een onbegrepen lage concentratie 'high-density'-lipoproteïnecholesterol.