[Use of the NSAID ketoprofen lysine salt in glucose-6-phosphate dehydrogenase (G6PD) deficiency in inflammatory disease in children].
Nineteen young females, aged 4 months-13 years, suffering from intermediate erythrocyte G6PD deficiency plus 14 hemizygote males, aged 6 months and 16 years, and one dizigote and completely deficient female were treated with ketoprofen lysine salt for upper and lower respiratory tract diseases. The drug was administered rectally at the dose of 30 or 60 mg twice or thrice a day according to the weight of the patients, i.e. around 2,5 mg ketoprofen lysine salt pro kg. Concomitant drugs were present in 6 cases, i.e. antibiotics and or inhaled corticosteroids. Fever disappeared within two days in 80% of cases. No systemic and/or local adverse event or haemolysis was evident both clinically and at laboratory analysis. Ketoprofen lysine salt, when administered for a short time period, is effective and safe also in G6PD deficient patients.
Corda
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Clinica Pediatrica Universitaria di Cagliari, Italia.
Carnelli
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D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007660:Ketoprofen / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008239:Lysine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male
D000894:Anti-Inflammatory Agents, Non-Steroidal; C029946:ketoprofen lysine; D007660:Ketoprofen; D008239:Lysine
Uso del FANS ketoprofene sale di lisina nella carenza di glucosio-6-fosfato deidrogenasi (G6PD) eritrocitaria in corso di affezioni flogistiche di interesse pediatrico.