[Clinical efficacy of silver sulfadiazine (AgSD: Geben cream) for ulcerative skin lesions infected with MRSA].
The clinical efficacy was evaluated on 1% silver sulfadiazine (AgSD) cream (Geben cream) for the treatment of ulcerative skin lesions infected with MRSA (methicillin-resistant Staphylococcus aureus). 1% AgSD cream was applied once a day to cutaneous ulcers such as burns or decubitus or various other ulcers, infected with MRSA, in 13 patients. MRSA was eradicated in 45.5% of 11 evaluable patients. The clinical efficacy rate of 1% AgSD cream was 72.7% in this series of treatment. No side effects were noted in any of the patients, either locally or systemically. The results of the present study have indicated that 1% AgSD cream is useful for cutaneous ulcers such as burns or decubitus, infected with MRSA.
Yoshida
T
T
Department of Plastic and Reconstructive Surgery, School of Medicine, Hokkaido University.
Ohura
T
T
Sugihara
T
T
Yoshida
T
T
Ishikawa
T
T
Homma
K
K
Kouraba
S
S
Kimura
C
C
Murazumi
M
M
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D016106:Methicillin Resistance; D008875:Middle Aged; D009824:Ointments; D012837:Silver Sulfadiazine / Q000008:administration & dosage*; D017192:Skin Diseases, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D012883:Skin Ulcer / Q000188:drug therapy* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000302:isolation & purification
D000891:Anti-Infective Agents, Local; D009824:Ointments; D012837:Silver Sulfadiazine