Comparison of cocaine-induced vasoconstriction of left and right coronary arterial systems.
In patients undergoing cardiac catheterization, we measured left and right coronary arterial dimensions before and 15 minutes after intranasal saline (n = 8) or cocaine (n = 8). In response to cocaine, left and right coronary arterial areas declined by 11 +/- 6% and 12 +/- 11%, respectively; thus, intranasal cocaine induces a similar magnitude of vasoconstriction of the left and right coronary arteries.
Vongpatanasin
W
W
Department of Internal Medicine Cardiovascular Division, University of Texas Southwestern Medical Center, Dallas 75235-9047, USA.
Lange
R A
RA
Hillis
L D
LD
D000281:Administration, Intranasal; D000328:Adult; D000368:Aged; D003042:Cocaine / Q000494:pharmacology*; D003331:Coronary Vessels / Q000187:drug effects*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012965:Sodium Chloride / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects*; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D014662:Vasoconstrictor Agents; D012965:Sodium Chloride; D003042:Cocaine