title: Langerhans cell histiocytosis mimicking malignancy: a radiological appraisal.
abstract: OBJECTIVE
  To analyze the radiologic characteristics, clinical course and long-term follow-up of 7 radiologically uncommon pediatric cases of Langerhans cell histiocytosis and to identify prognostic factors related to imaging patterns.
  
  
  METHODS
  The clinical records and complete imaging data of 75 patients with LCH diagnosed and treated at the National Cancer Institute of Milan between January 1975 and December 1993 were analyzed, and 43 cases presenting as unifocal bone lesions were identified. The plain film, computed tomography and magnetic resonance characteristics enabled the identification of 7 radiologically aggressive and rapidly progressive cases, which were analyzed at presentation and during follow-up.
  
  
  RESULTS
  Although at disease presentation bone lesions appeared lytic destructive, rapidly progressive and often involved adjacent soft tissues, after adequate therapy the disease course was invariably benign and led to almost complete restoration of normal structure and function. Long-term follow-up confirmed the favorable outcome and lack of disease recurrence in all cases.
  
  
  CONCLUSIONS
  There is no correlation between radiologically aggressive characteristics and final outcome in Langerhans cell histiocytosis. Radiologists and pediatric oncologists should be acquainted with less common radiologic forms which, at presentation, can mimic more ominous diseases. If recognized and adequately treated, monostotic forms almost invariably have a benign prognosis.
authors.affiliation: Department of Diagnostic Radiology A, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Potepan
authors.forename: J D
authors.initials: JD
authors.lastname: Tesoro-Tess
authors.forename: A
authors.initials: A
authors.lastname: Laffranchi
authors.forename: G M
authors.initials: GM
authors.lastname: Danesini
authors.forename: C
authors.initials: C
authors.lastname: Gianni
authors.forename: E
authors.initials: E
authors.lastname: Uslenghi
authors.forename: I
authors.initials: I
authors.lastname: Spagnoli
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D006646:Histiocytosis, Langerhans-Cell / Q000000981:diagnostic imaging*; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D011379:Prognosis; D014057:Tomography, X-Ray Computed