The ER-overload response: activation of NF-kappa B.
Various conditions that perturb the function of the endoplasmic reticulum (ER) were recently shown to activate the transcription factor NF-kappa B. Activation of NF-kappa B is caused by the accumulation of proteins in the ER membrane, a condition we have called ER overload. Both the release of Ca2+ from the ER and the subsequent production of reactive oxygen intermediates are required for ER-overload-mediated NF-kappa B activation. This novel intracellular signal transduction pathway might be important in antiviral defense and play a role in various diseases as well as in B-cell development.
Pahl
H L
HL
Institute for Experimental Cancer Research, Tumor Biology Center, Freiburg, Germany. pahl@sun2.ruf.uni-freiburg.de
Baeuerle
P A
PA
D000818:Animals; D002118:Calcium / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
D016328:NF-kappa B; D017382:Reactive Oxygen Species; D002118:Calcium