Enhancement of UV-A-induced cytotoxicity to cancer cell lines by camptothecin.
The exposure of cultured mouse melanoma (B-16) cells, to camptothecin (CAM) after irradiation of the cells with UV-A synergistically enhanced cytotoxicity. CAM treatment prior to irradiation had the same effect. Similar results were also obtained with the combination of gamma-ray irradiation and CAM in this model. Thus, the sensitivity of the cells to UV-A and gamma-ray irradiation was significantly elevated by CAM. These findings have potential clinical utility.
Kojima
S
S
Research Institute for Biosciences, Science University of Tokyo, Chiba, Japan.
Fujishima
H
H
Wang
D S
DS
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002166:Camptothecin / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D008546:Melanoma, Experimental / Q000532:radiotherapy*; D051379:Mice; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014466:Ultraviolet Rays
D000972:Antineoplastic Agents, Phytogenic; D011838:Radiation-Sensitizing Agents; D004247:DNA; D002166:Camptothecin