The use of tolerance for transplantation across xenogeneic barriers.
The success of human organ transplantation as a clinical treatment has created a conundrum for the transplant community. It has caused a shortage of human donor organs and uncovered problems of chronic immunosuppression in those lucky enough to receive organ transplants due to their use of chronic immunosuppressive drugs. Our aim is to attempt to approach both issues by establishing specific transplantation tolerance to pig organ grafts.
Greenstein
J L
JL
Bio Transplant Incorporated, Charlestown Navy Yard, MA 02129, USA.
Sachs
D H
DH
D000222:Adaptation, Physiological / Q000276:immunology*; D000818:Animals; D002678:Chimera; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D011323:Primates; D013552:Swine; D013556:Swine, Miniature; D014019:Tissue Donors; D014183:Transplantation, Heterologous / Q000276:immunology*
D007166:Immunosuppressive Agents