Dietary docosahexaenoic acid (22: 6n-3) prevents the development of hypertension in SHRSP.
1. We previously reported that hypertension in stroke-prone spontaneously hypertensive rats (SHRSP) caused renal membrane phospholipid degradation. Renal phospholipase A2 activity increased and membranous phospholipids decreased along with age in SHRSP. Membranous abnormalities induced by membrane fluidity and calcium permeability changes may contribute to the elevation of blood pressure in SHRSP. DHA, a major component of fish oil, constitutes a part of membrane phospholipid acylchains. 2. The purpose of this study was to clarify the effect of DHA on the relationship between the renal function and the development of hypertension in SHRSP. 3. Six week old male SHRSP were fed a semi-purified diet supplemented with DHA (0, 1 and 5%) for 14 weeks. 4. The systolic blood pressure of control SHRSP (DHA 0%) significantly increased from 120.2 mmHg to 202.9 mmHg. This increase in systolic blood pressure was significantly inhibited in a dose-dependent manner by 1 and 5% DHA diet to 167.8 to 149.8 mmHg, respectively. 5. Serum creatinine concentration and blood urea nitrogen (BUN) were significantly lower in DHA (5%)-treated SHRSP than in the control SHRSP. 6. These results indicate that DHA prevents the development of hypertension in SHRSP, which is associated with changes in renal function.
Kimura
S
S
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan.
Minami
M
M
Saito
H
H
Kobayashi
T
T
Okuyama
H
H
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001806:Blood Urea Nitrogen; D002561:Cerebrovascular Disorders / Q000235:genetics / Q000503:physiopathology; D003404:Creatinine / Q000097:blood; D004032:Diet; D004281:Docosahexaenoic Acids / Q000627:therapeutic use*; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology / Q000517:prevention & control*; D007677:Kidney Function Tests; D051381:Rats; D011918:Rats, Inbred SHR
D004281:Docosahexaenoic Acids; D003404:Creatinine