title: Killing mechanisms of cytotoxic lymphocytes.
abstract: Killer lymphocytes are primary immune effectors of virus, certain bacteria, and tumor immunity and play a role in autoimmunity and transplant rejection. This article reviews progress in deciphering the mechanisms by which they kill target cells through induction of apoptosis by either the secretory, perforin/granzyme-based pathway or the nonsecretory pathway, (i.e., by triggering the cell-surface death receptor Fas (CD95) by the membrane-bound Fas ligand of the killer).
authors.affiliation: Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
authors.forename: G
authors.initials: G
authors.lastname: Berke
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D006801:Humans; D013602:T-Lymphocytes, Cytotoxic; D019014:fas Receptor / Q000276:immunology*
chemical_list: D019014:fas Receptor