title: Persistent efficacy of topical moxidectin against Dictyocaulus viviparus and Ostertagia ostertagi.
abstract: The persistent activity of moxidectin topically administered at the dose rate of 0.5 mg kg-1 bodyweight was evaluated against experimental nematode infection in 30 calves randomly allocated to six groups. Five groups were treated on days -42, -35, -28, -21 and -14. The 6th group remained untreated as a control. On Day 0, the calves were infected experimentally with 1000 Dictyocaulus viviparus and 50,000 Ostertagia ostertagi larvae and killed 3 weeks later. The formulation of moxidectin showed excellent activity against both parasites for up to 5 weeks (> 99%). Six weeks after treatment the reduction in the number of D. viviparus was still high (> 90%). No adverse reactions to moxidectin were observed in any of the animals.
authors.affiliation: INRA Station de Pathologie Aviaire et de Parasitologie, Unité d'Helminthologie, Nouzilly, France.
authors.forename: J
authors.initials: J
authors.lastname: Hubert
authors.forename: D
authors.initials: D
authors.lastname: Kerboeuf
authors.forename: B
authors.initials: B
authors.lastname: Cardinaud
authors.forename: F
authors.initials: F
authors.lastname: Blond-Riou
authors.forename: R
authors.initials: R
authors.lastname: Fournier
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents; D002417:Cattle; D002418:Cattle Diseases; D004022:Dictyocaulus Infections / Q000188:drug therapy* / Q000517:prevention & control; D007814:Larva; D018942:Macrolides / Q000008:administration & dosage / Q000627:therapeutic use; D010029:Ostertagiasis / Q000188:drug therapy / Q000662:veterinary*; D013997:Time Factors
chemical_list: D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D018942:Macrolides; C027837:moxidectin