title: Healing of laser incisions in rat dermis: comparisons of the carbon dioxide laser under manual and computer control and the scalpel.
abstract: OBJECTIVE
  The Computer-Assisted Surgical Techniques (CAST) program was researched to decrease lateral tissue damage and improve wound healing subsequent to laser incision. CAST differs from the traditional laser because it makes the incision in a discontinuous manner, allowing tissue to cool during the incision process.
  
  
  METHODS
  The transient temperature changes in the tissue adjacent to the incision were measured with a thermocouple in a rat model. The subsequent wound healing was studied with histology and tensiometry.
  
  
  RESULTS
  The thermal measurements demonstrated that all CAST settings were cooler than the continuous mode of laser incision. However, histology and tensiometric studies showed mixed results.
  
  
  CONCLUSIONS
  This research demonstrates that CAST can be used in future surgical applications with no delay in wound healing as compared to the manually controlled laser. However, this study also finds no decrease in the wound healing time when using the CAST program.
authors.affiliation: Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
authors.forename: J
authors.initials: J
authors.lastname: Howard
authors.forename: P
authors.initials: P
authors.lastname: Arango
authors.forename: J
authors.initials: J
authors.lastname: Ossoff
authors.forename: R H
authors.initials: RH
authors.lastname: Ossoff
authors.forename: L
authors.initials: L
authors.lastname: Reinisch
mesh_terms: D000818:Animals; D062109:Dermatologic Surgical Procedures; D053685:Laser Therapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012371:Robotics; D012867:Skin / Q000473:pathology; D013718:Tensile Strength; D013813:Therapy, Computer-Assisted; D014945:Wound Healing