title: [Spinal para-medullary conduction anesthesia in therapy with anticoagulant drugs].
abstract: Epidural and spinal blocks can lead to iatrogenic bleeding in the spinal canal. Incidence of this severe complication is considered low, but the risk of irreversible neurological defects for the patient requires increased attention by the anaesthetist. The perioperative risk is higher in patients under anticoagulant therapy. The different pharmacodynamics and pharmacokinetics of practically relevant anticoagulants are discussed and recommendations for the performance of centroneuraxis blocks in patients under anticoagulant therapy are given.
authors.affiliation: Klinik und Poliklinik für Anästhesiologie und Intensivmedizin, Ernst-Mortiz-Arndt-Universität Greifswald.
authors.forename: T
authors.initials: T
authors.lastname: Hesse
authors.forename: D
authors.initials: D
authors.lastname: Holst
authors.forename: M
authors.initials: M
authors.lastname: Möllmann
authors.forename: M
authors.initials: M
authors.lastname: Wendt
mesh_terms: D000767:Anesthesia, Epidural / Q000009:adverse effects*; D000775:Anesthesia, Spinal / Q000009:adverse effects*; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D006470:Hemorrhage / Q000097:blood / Q000139:chemically induced*; D006801:Humans; D012307:Risk Factors; D013122:Spinal Diseases / Q000097:blood / Q000139:chemically induced*
chemical_list: D000925:Anticoagulants
vernacular_title: Rückenmarknahe Leitungsanästhesie bei Therapie mit gerinnungshemmenden Medikamenten.