[Investigation of immune response in rubber workers at high risk for cancer].
The study was concerned with immune response in the workers engaged in rubber manufacture which is a cancer hazard. A group of healthy donors were in control. The study group was divided into those free from carcinogen-protein adducts (CPA) and those who revealed them and, therefore, are considered at high risk for cancer. CPAs containing benzidine, 2-naphtylamine or 3-oxyanthranyl acid were assayed in blood serum. B- and T-immunity inhibition was shown to be present in both study sub-groups. A significant difference in immune response indices was established between the CPA-free and CPA-containing groups of the rubber workers. The latter group had relatively higher levels of IgA, IgM and globulins of immunocomplexes, and revealed inhibition of formation of antibody-forming cells to ovine erythrocytes following injection of CPA-containing blood serum into mice as well as relatively higher suppression of T-cell immunity in the workers at high risk.
Belokhvostova
A T
AT
Potapenkova
L S
LS
Kaverzneva
T T
TT
D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood; D001402:B-Lymphocytes / Q000276:immunology*; D002273:Carcinogens / Q000009:adverse effects*; D016022:Case-Control Studies; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007221:Industry; D008875:Middle Aged; D011506:Proteins / Q000276:immunology*; D012408:Rubber; D013601:T-Lymphocytes / Q000276:immunology*
D000936:Antigen-Antibody Complex; D002273:Carcinogens; D007070:Immunoglobulin A; D007075:Immunoglobulin M; D011506:Proteins; D012408:Rubber
Issledovanie immunoreaktivnosti u rabochikh rezinovoĭ promyshlennosti v gruppe povyshennogo onkologicheskogo riska.