Furanocoumarins with affinity to brain benzodiazepine receptors in vitro.
Eight furanocoumarins were isolated from a methanol extract of dried roots of Angelica dahurica. One of these, phellopterin, strongly (IC50 = 0.36 microM) inhibits the binding of [3H]diazepam to central nervous system benzodiazepine receptors in vitro, while the others, despite their structural similarities with phellopterin, are considerably less active.
Bergendorff
O
O
Division of Organic Chemistry 2, University of Lund, Sweden.
Dekermendjian
K
K
Nielsen
M
M
Shan
R
R
Witt
R
R
Ai
J
J
Sterner
O
O
D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003975:Diazepam / Q000378:metabolism*; D005663:Furans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D018517:Plant Roots; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism*
D003374:Coumarins; D005663:Furans; D011963:Receptors, GABA-A; C104601:phellopterin; D003975:Diazepam