title: Impairment of left ventricular function by acute cardiac lymphatic obstruction.
abstract: OBJECTIVE
  We performed the following study to define the effects of acute cardiac lymphatic obstruction on left ventricular (LV) systolic and diastolic function.
  
  
  METHODS
  Cardiac lymphatic obstruction was created in 8 pentobarbital-anesthetized dogs by identifying (Evans blue) and ligating the right and left epicardial lymphatics, the afferent and efferent lymphatics associated with the pretrachael and cardiac lymph nodes, and the thoracic duct. Left ventricular function was assessed by analysis of micromanometer-conductance catheter-derived LV pressure-volume relationships. Contractility was assessed by preload recruitable stroke work (PRSW). The active and passive phases of LV relaxation were assessed by the time constant o isovolumic relaxation (tau) and the end-diastolic pressure-volume relationship (stiffness), respectively.
  
  
  RESULTS
  PRSW decreased significantly and tau increased significantly from baseline at 1, 2, and 3 h after cardiac lymphatic obstruction (n = 8), but stiffness did not change. Cardiac lymphatic obstruction had similar effects on LV function in a group of autonomically blocked dogs (n = 5). Left ventricular function did not change in sham treated controls (n = 8). Cardiac lymphatic obstruction induced a significant increase in LV wet/dry weight ratios (3.58 +/- 0.01) when compared to the control group (3.53 +/- 0.02). Histopathology of the myocardium in the lymphatic obstruction groups revealed significant lymphangiectasis and increased interstitial spacing when compared to controls.
  
  
  CONCLUSIONS
  Acute cardiac lymphatic obstruction depresses contractility and active relaxation and causes mild LV myocardial edema, but does not alter diastolic stiffness.
authors.affiliation: Department of Surgery, Ohio State University, Columbus 43210, USA.
authors.forename: L L
authors.initials: LL
authors.lastname: Ludwig
authors.forename: E R
authors.initials: ER
authors.lastname: Schertel
authors.forename: J W
authors.initials: JW
authors.lastname: Pratt
authors.forename: D E
authors.initials: DE
authors.lastname: McClure
authors.forename: A J
authors.initials: AJ
authors.lastname: Ying
authors.forename: C F
authors.initials: CF
authors.lastname: Heck
authors.forename: P D
authors.initials: PD
authors.lastname: Myerowitz
mesh_terms: D000208:Acute Disease; D000818:Animals; D001340:Autonomic Nerve Block; D003971:Diastole; D004285:Dogs; D004489:Edema, Cardiac / Q000503:physiopathology*; D008297:Male; D009200:Myocardial Contraction; D013318:Stroke Volume; D013599:Systole; D016277:Ventricular Function, Left