Effect of theophylline on adaptation of the heart to myocardial ischemia during percutaneous transluminal coronary angioplasty in patients with stable angina pectoris.
This study was designed to examine whether theophylline, an adenosine receptor antagonist, affects cardiac adaptation to ischemia during progression of repetitive balloon inflations of percutaneous transluminal coronary angioplasty (PTCA). Theophylline abolished this cardiac adaptation, suggesting that endogenous adenosine is a key mediator for cardiac adaptation during PTCA.
Hashimura
K
K
Cardiovascular Division, Ishinkai Yao General Hospital, Oska, Japan.
Kijima
Y
Y
Matsu-ura
Y
Y
Ueda
T
T
Kato
Y
Y
Mori
I
I
Minamino
T
T
Kitakaze
M
M
Hori
M
M
D000222:Adaptation, Physiological / Q000187:drug effects*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000188:drug therapy; D058915:Purinergic P1 Receptor Antagonists; D013806:Theophylline / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*
D058915:Purinergic P1 Receptor Antagonists; D014665:Vasodilator Agents; D013806:Theophylline