Synthesis and antitumor activity of spin labeled derivatives of podophyllotoxin.
Three new nitroxyl labeled derivatives of podophyllotoxin 4-6 have been synthesized and evaluated for their antitumor activity in vitro. Compounds 4-6 showed significant inhibitory activity against human nasopharyngeal carcinoma KB,lung cancer A549 and stomach carcinoma SGC-7901 cells, as well as mouse leukemia L1210 and P388 cells. Compounds 4 and 5 exhibited comparable or superior activity to clinically used etoposide (VP-16,2) in their inhibition of these cell lines.
Tian
X
X
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, P.R. China.
Wang
Y G
YG
Yang
M G
MG
Chen
Y Z
YZ
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D011034:Podophyllotoxin / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013113:Spin Labels; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D013113:Spin Labels; D011034:Podophyllotoxin