T-cell receptors: feeling out the complex.
Recent crystallographic studies show that the T-cell receptor has a largely immunoglobulin-like structure and binds to MHC-peptide complexes through loops from paired Valpha and Vbeta domains that focus on the central amino acids of the MHC-bound peptide, and to bacterial superantigens via peripheral aspects of the Vbeta domain.
Padlan
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EA
Laboratory of Molecular Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-1892, USA.
Marguilies
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DH
D006801:Humans; D007136:Immunoglobulins / Q000737:chemistry; D008285:Major Histocompatibility Complex / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry*
D007136:Immunoglobulins; D011948:Receptors, Antigen, T-Cell