title: PACAP type I receptor gene expression in the paraventricular and supraoptic nuclei of rats.
abstract: We have examined the distribution of pituitary adenylate cyclase-activating polypeptide (PACAP) type I receptor gene expression in the rat paraventricular (PVN) and supraoptic nuclei (SON) using in situ hybridization histochemistry. PACAP type I receptor gene was expressed moderately in the whole area of the PVN and the SON. In particular, PACAP type I gene transcripts were found in both the magnocellular and the parvocellular parts of the PVN. The results are consistent with the hypothesis that neurosecretory cells in the PVN and the SON might be modulated by PACAP through PACAP type I receptor.
authors.affiliation: Department of Physiology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nomura
authors.forename: Y
authors.initials: Y
authors.lastname: Ueta
authors.forename: R
authors.initials: R
authors.lastname: Serino
authors.forename: N
authors.initials: N
authors.lastname: Kabashima
authors.forename: I
authors.initials: I
authors.lastname: Shibuya
authors.forename: H
authors.initials: H
authors.lastname: Yamashita
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000096:biosynthesis / Q000235:genetics; D003346:Corticotropin-Releasing Hormone / Q000096:biosynthesis / Q000235:genetics; D015870:Gene Expression; D006651:Histocytochemistry; D017403:In Situ Hybridization; D008297:Male; D009479:Neuropeptides / Q000378:metabolism / Q000502:physiology; D018377:Neurotransmitter Agents / Q000378:metabolism / Q000502:physiology; D010121:Oxytocin / Q000096:biosynthesis / Q000235:genetics; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism*; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D051381:Rats; D017208:Rats, Wistar; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; D011979:Receptors, Pituitary Hormone / Q000096:biosynthesis* / Q000235:genetics; D013462:Sulfur Radioisotopes; D013495:Supraoptic Nucleus / Q000378:metabolism*
chemical_list: C495403:Adcyap1 protein, rat; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; D011979:Receptors, Pituitary Hormone; D013462:Sulfur Radioisotopes; D001127:Arginine Vasopressin; D010121:Oxytocin; D003346:Corticotropin-Releasing Hormone