Genetic recombination: sex-change operations in yeast.
The 'directionality' of mating-type switching in building yeast is determined by mechanisms that regulate genetic recombination along the whole left arm of chromosome III. In MATa cells, a cis-acting 'recombinational enhancer' activates this entire region, while in MATalpha cells the enhancer is turned off by the alpha2 repressor.
Shore
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Department of Molecular Biology, University of Geneva, 30 quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland. David.Shore@molbio.unige.ch
D015825:Chromosomes, Fungal; D004742:Enhancer Elements, Genetic; D005800:Genes, Fungal; D049770:Genes, Mating Type, Fungal; D011995:Recombination, Genetic; D012098:Reproduction; D012441:Saccharomyces cerevisiae / Q000235:genetics*