Candidates for cognitive enhancer extracted from medicinal plants: paeoniflorin and tetramethylpyrazine.
A traditional Chinese medicine, Shimotsu-to, consisting of four herbs: Japanese angelica root, cnidium rhizome, peony root and rehmannia root, has been reported to improve spatial working memory in rats. The present results indicate that Paeoniflorin and tetramethylpyrazine (TMP) extracted from peony root and cnidium rhizome, respectively, are candidates for cognitive enhancer.
Watanabe
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Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University, Japan.
D000375:Aging / Q000523:psychology; D000818:Animals; D001479:Basal Ganglia / Q000502:physiology; D001565:Benzoates; D001952:Bridged-Ring Compounds; D003071:Cognition / Q000187:drug effects*; D004193:Discrimination Learning / Q000187:drug effects; D016166:Free Radical Scavengers / Q000494:pharmacology; D005960:Glucosides / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008570:Memory, Short-Term / Q000187:drug effects; D039821:Monoterpenes; D018697:Nootropic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D017208:Rats, Wistar; D006027:Glycosides
D001565:Benzoates; D001952:Bridged-Ring Compounds; D016166:Free Radical Scavengers; D005960:Glucosides; D039821:Monoterpenes; D018697:Nootropic Agents; D011719:Pyrazines; C015423:peoniflorin; D006027:Glycosides; C017953:tetramethylpyrazine