title: Inhibition by hop bract polyphenols of cellular adherence and water-insoluble glucan synthesis of mutans streptococci.
abstract: The inhibitory effect of hop bract polyphenols (HBP) on cariogenic streptococci was investigated. It was found that the high molecular weight polyphenol (estimated about 36,000-40,000) inhibited the cellular adherence of Streptococcus mutans MT8148 (serotype C) and Streptococcus sobrinus ATCC 33478 (serotype g) at much small concentrations than the polyphenols extracted from oolong tea or green tea leaves. Furthermore, HBP also inhibited the action of glucosyltransferase, which was involved in the water-insoluble glucan synthesis, but did not suppress the growth and the acid production of the bacteria. These results suggest that HBP would be a candidate to act against dental caries caused by Mutans Streptococci.
authors.affiliation: Bioscience Research & Development Laboratory, Asahi Breweries Ltd., Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tagashira
authors.forename: K
authors.initials: K
authors.lastname: Uchiyama
authors.forename: T
authors.initials: T
authors.lastname: Yoshimura
authors.forename: M
authors.initials: M
authors.lastname: Shirota
authors.forename: N
authors.initials: N
authors.lastname: Uemitsu
mesh_terms: D001422:Bacterial Adhesion / Q000187:drug effects*; D003731:Dental Caries / Q000517:prevention & control; D005419:Flavonoids; D005936:Glucans / Q000096:biosynthesis*; D005964:Glucosyltransferases / Q000378:metabolism; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts; D010946:Plants, Medicinal / Q000737:chemistry*; D011108:Polymers / Q000302:isolation & purification / Q000494:pharmacology*; D059808:Polyphenols; D013295:Streptococcus mutans / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D016986:Streptococcus sobrinus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D014867:Water
chemical_list: D005419:Flavonoids; D005936:Glucans; D010636:Phenols; D010936:Plant Extracts; D011108:Polymers; D059808:Polyphenols; D014867:Water; D005964:Glucosyltransferases