A new perspective in ocular infection and the role of antibiotics.
A new concept of ocular infectious diseases includes two modes of pathogenesis, one being an acute inflammation caused by the attachment of free-floating bacteria, and another being intractable biofilm-related ocular infections. 15-20% of Staphylococcus epidermidis strains isolated from human conjunctiva exhibit slime formation and can be pathogens causing inflammation. Topical application, in the form of, for example, eye drops, of a combination of two antimicrobial agents is usually applied to treat such infections. Any antimicrobial agent having a post-antibiotic effect is generally administered in a twice-a-day regimen.
Miyanaga
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Department of Ophthalmology, Tokyo Women's Medical College, Daini Hospital, Japan.
D000818:Animals; D000900:Anti-Bacterial Agents; D001419:Bacteria / Q000648:ultrastructure; D016667:Bacterial Capsules / Q000502:physiology; D018407:Bacterial Physiological Phenomena; D018441:Biofilms; D003228:Conjunctiva / Q000382:microbiology / Q000648:ultrastructure; D003315:Cornea / Q000382:microbiology / Q000648:ultrastructure; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D015818:Eye Infections, Bacterial / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans
D000900:Anti-Bacterial Agents