[A comparative study of the cholinesterase and carboxylesterase sensitivities of mammals and arthropods to new phenyl and glycidyl esters of dialkyl thiophosphoric acid].
The antienzymic activities of 14 organophosphorous compounds, the derivatives of dialkyl thiophosphoric acid, towards the acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and carboxylesterase (CE) from the spring grain aphid and mammals were investigated. The dependence of inhibitory activity of the compounds on their alkyl radical length was shown to be different for the AchE from the aphid and man. Some less pronounced differences in this dependence were revealed between the BuChEs from the aphid and horse as well as between the CEs from the aphid, mouse and red spider mite. The data give evidence of a distinction in structure of the active surfaces of the enzymes from the aphid and mammals. Some peculiar properties of the aphid cholinesterases are discussed taking account of the results of the present and previous papers.
Brestkin
A P
AP
Kormilitsyn
B N
BN
Kugusheva
L I
LI
Maĭzel'
E B
EB
Moralev
S N
SN
Mukanova
K D
KD
Khovanskikh
A E
AE
Abduvakhabov
A A
AA
Babaev
B N
BN
Dalimov
D N
DN
D000818:Animals; D001042:Aphids / Q000201:enzymology; D002265:Carboxylic Ester Hydrolases / Q000187:drug effects* / Q000302:isolation & purification; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D002802:Cholinesterases / Q000187:drug effects* / Q000302:isolation & purification; D004912:Erythrocytes / Q000201:enzymology; D006736:Horses; D006801:Humans; D008099:Liver / Q000201:enzymology; D051379:Mice; D008807:Mice, Inbred BALB C; D008925:Mites / Q000201:enzymology; D063086:Organothiophosphates / Q000494:pharmacology*; D012995:Solubility
D002800:Cholinesterase Inhibitors; D063086:Organothiophosphates; D002265:Carboxylic Ester Hydrolases; D002802:Cholinesterases
Sravnitel'noe issledovanie chuvstvitel'nosti kholinesteraz i karboksilésteraz nekotorykh mlekopitaiushchikh i chlenistonogikh k novym fenilovym i glitsidilovym éfiram dialkiltiofosfornoĭ kisloty.