Evaluation of renal acidification in HIV-infected patients with hypergammaglobulinemia.
Distal renal tubular acidosis has been reported in several diseases associated with hypergammaglobulinemia, particularly Sjögren's syndrome. Since HIV infection is now a common cause of hypergammaglobulinemia, we evaluated renal acidification under basal and dynamic conditions in 8 asymptomatic HIV-seropositive subjects. Basal acid-base status was normal in all except 1 patient who had respiratory acidosis subsequent to recent pneumonia. Acid-loading tests showed normal acid excretion except for 1 patient who had low acid excretion attributed to non-ingestion of the ammonium chloride capsules. Bicarbonate-loading tests showed normal distal acidification indexes in 7 patients. The only patient with a low acidification defect was diagnosed 2 weeks later as having tuberculosis. Our results suggest that hypergammaglobulinemia per se is not a sufficient condition to induce renal tubular acidosis.
Seux-Levieil
M L
ML
Service de Médecine interne, Hospitalo-Universitaire Bichat-Claude Bernard, Paris, France.
Joly
V
V
Yeni
P
P
Carbon
C
C
Blanchet
F
F
D000141:Acidosis, Renal Tubular / Q000097:blood / Q000209:etiology* / Q000652:urine; D000328:Adult; D005069:Evaluation Studies as Topic; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000150:complications* / Q000652:urine; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006942:Hypergammaglobulinemia / Q000097:blood / Q000209:etiology* / Q000652:urine; D008297:Male; D017693:Sodium Bicarbonate / Q000008:administration & dosage / Q000097:blood; D005719:gamma-Globulins / Q000378:metabolism
D005719:gamma-Globulins; D017693:Sodium Bicarbonate