[Benzodiazepines in geriatrics--a case report on prolonged action].
Due to the age-dependent changes of pharmacodynamic and pharmcokinetic, the frequency of undesirable side-effects of benzodiazepines is higher in geriatric patients. An increased sensitivity to benzodiazepines and their metabolites can induce extremely prolonged duration of action leading to unconsciousness and respiratory insufficiency. Because of an assumed postoperative "psychosyndrome", a 72-year-old patient was treated with high doses of diazepam combined with single doses of tramal, clonidin and ranitidin. This treatment was followed by the development of respiratory insufficiency requiring intensive care with intubation for 8 days including assisted ventilation for 2 days. The serum concentrations of diazepam and its metabolites lay within the therapeutic range until the 7th day after the end of application. Therefore, the authors conclude that when using benzodiazepines in geriatric patients, the physiological peculiarities of this age group and possible interactions with other drugs leading to an increase in potency must be carefully considered.
Dressler
C
C
Abteilung für Anaesthesie und Intensivtherapie, Krankenhauses im Friedrichshain-Berlin.
Franke
K P
KP
Herzig
M
M
Nagel
U
U
D000368:Aged; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D003704:Dementia / Q000097:blood / Q000188:drug therapy*; D003975:Diazepam / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D004239:Diverticulitis, Colonic / Q000601:surgery*; D004359:Drug Therapy, Combination; D004630:Emergencies; D005260:Female; D006801:Humans; D007416:Intestinal Perforation / Q000601:surgery*; D008657:Metabolic Clearance Rate / Q000502:physiology; D003708:Nordazepam / Q000493:pharmacokinetics; D011183:Postoperative Complications / Q000097:blood / Q000188:drug therapy*
D014151:Anti-Anxiety Agents; D003708:Nordazepam; D003975:Diazepam
Benzodiazepine in der Geriatrie--ein kasuistischer Beitrag zum Effekt einer Wirkungsverlängerung.