title: Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation.
abstract: OBJECTIVE
  To investigate the association between the apolipoprotein E (APOE) genotypes and dementia in patients with stroke, defined as either vascular dementia (VaD) or Alzheimer disease with cerebrovascular disease (AD with CVD).
  
  
  METHODS
  Population-based, case-control study from Rotterdam, the Netherlands, and New York City.
  
  
  METHODS
  A total of 187 patients with dementia and stroke were compared with 507 controls similar in age and ethnic group.
  
  
  METHODS
  The APOE allele frequencies in patients and controls; the odds ratio of dementia with stroke, VaD, and AD with CVD, adjusted for age, sex, residency, and education; and the percent attributable risk related to the APOE epsilon4 allele.
  
  
  RESULTS
  Overall, patients with dementia and stroke had a higher APOE epsilon4 allele frequency than controls. Compared with APOE epsilon3 homozygote individuals, APOE epsilon4 homozygotes had a 7-fold increased risk of dementia with stroke (OR=6.9; 95% CI, 1.6-29.4), while APOE epsilon4 heterozygotes had nearly a 2-fold increase in risk (OR=1.8; 95% CI, 1.2-2.7). Risks associated with APOE epsilon4 were elevated regardless of the subtype of dementia with stroke or age or sex. The percent attributable risk related to the APOE epsilon4 allele among demented patients with stroke was 41% overall, 33% among those with VaD, and 44% among those with AD with CVD.
  
  
  CONCLUSIONS
  The APOE epsilon4 allele is a genetic risk factor for dementia with stroke, including VaD and AD with CVD. This may imply shared genetic susceptibility to dementia associated with stroke and AD. Alternatively, the category of patients with dementia and stroke, including VaD as currently defined, may include patients with AD.
authors.affiliation: Gertrude H. Sergievsky Center, Columbia University, New York, NY 10032, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Slooter
authors.forename: M X
authors.initials: MX
authors.lastname: Tang
authors.forename: C M
authors.initials: CM
authors.lastname: van Duijn
authors.forename: Y
authors.initials: Y
authors.lastname: Stern
authors.forename: A
authors.initials: A
authors.lastname: Ott
authors.forename: K
authors.initials: K
authors.lastname: Bell
authors.forename: M M
authors.initials: MM
authors.lastname: Breteler
authors.forename: C
authors.initials: C
authors.lastname: Van Broeckhoven
authors.forename: T K
authors.initials: TK
authors.lastname: Tatemichi
authors.forename: B
authors.initials: B
authors.lastname: Tycko
authors.forename: A
authors.initials: A
authors.lastname: Hofman
authors.forename: R
authors.initials: R
authors.lastname: Mayeux
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000704:Analysis of Variance; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D002561:Cerebrovascular Disorders / Q000150:complications* / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D003704:Dementia / Q000150:complications* / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D009483:Neuropsychological Tests; D012307:Risk Factors
chemical_list: D001057:Apolipoproteins E