Quassinoids as inhibitors of Epstein-Barr virus early antigen activation.
Short-term in vitro assays for tumor promoters and antitumor promoters (Epstein-Barr virus activation test) were carried out for 14 quassinoids isolated from Ailanthus altissima. Some quassinoids, including ailantinol B, ailantinol C, ailanthone, and shinjulactone A, showed moderate activity at a molar ratio of 1:100 (TPA/quassinoids), and the results led to the elucidation of structure-activity relationships.
Kubota
K
K
Department of Interdisciplinary Studies on Natural Environment, Faculty of Integrated Arts, Hiroshima University, Kagamiyama, Japan.
Fukamiya
N
N
Tokuda
H
H
Nishino
H
H
Tagahara
K
K
Lee
K H
KH
Okano
M
M
D000956:Antigens, Viral / Q000378:metabolism*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002273:Carcinogens / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D005900:Glaucarubin / Q000031:analogs & derivatives / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013755:Tetradecanoylphorbol Acetate / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000956:Antigens, Viral; D000972:Antineoplastic Agents, Phytogenic; D002273:Carcinogens; C033305:Epstein-Barr virus early antigen; D005900:Glaucarubin; D013755:Tetradecanoylphorbol Acetate