title: Incidence of acute oligoanuric renal failure in dextran 40 treated patients with acute ischemic stroke stage III or IV.
abstract: Two hundred eleven patients with acute ischemic stroke, stage III or IV, received daily intravenous infusion of 500-1000 mL low-molecular dextran (dextran 40) over a period of 4 days. In 10 cases (4.7%) acute renal failure, associated with dextran infusion, could be observed; oligoanuria occurred after a mean time of 4 (3-6) days. The incidence of dextran-induced acute renal failure was significantly higher in patients with a preexisting reduction of glomerular filtration rate below 30 mL/min/1.73 m2 (p < 0.005). Five of the patients (50%) with acute renal failure died within 4-12 days after the hemodilution therapy with dextran 40; this high lethality was due to nonrenal complications.
authors.affiliation: Second Department of Medicine, General Hospital Linz, Austria.
authors.forename: G
authors.initials: G
authors.lastname: Biesenbach
authors.forename: W
authors.initials: W
authors.lastname: Kaiser
authors.forename: J
authors.initials: J
authors.lastname: Zazgornik
mesh_terms: D000208:Acute Disease; D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000503:physiopathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001002:Anuria / Q000139:chemically induced* / Q000503:physiopathology; D002545:Brain Ischemia / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D003911:Dextrans / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D015994:Incidence; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011859:Radiography; D017582:Renal Replacement Therapy; D012189:Retrospective Studies
chemical_list: D000925:Anticoagulants; D003911:Dextrans