title: [Foscarnet therapy for ganciclovir-refractory cytomegalovirus hepatitis in a patient who underwent bone marrow transplantation from an unrelated donor].
abstract: Cytomegalovirus (CMV) hepatitis refractory to ganciclovir treatment occurred after prolonged administration of ganciclovir in a 36-year-old woman with chronic myelogeneous leukemia who had undergone allogeneic bone marrow transplantation (BMT) from an HLA-identical unrelated donor. The number of CMV antigen-positive leukocytes in blood were well correlated with the serum levels of transaminases and the antigenemia assay was useful in monitoring CMV hepatitis. The patient was treated with foscarnet, a potent inhibitor of CMV DNA-polymerase, which led to rapid improvement of the CMV antigenemia and the transaminase concentrations. Foscarnet therapy should be considered for ganciclovir-resistant CMV disease in the setting of BMT.
authors.affiliation: First Department of Internal Medicine, Kyushu University.
authors.forename: T
authors.initials: T
authors.lastname: Fujisaki
authors.forename: H
authors.initials: H
authors.lastname: Gondo
authors.forename: N
authors.initials: N
authors.lastname: Uchida
authors.forename: I
authors.initials: I
authors.lastname: Matsuo
authors.forename: K
authors.initials: K
authors.lastname: Takenaka
authors.forename: K
authors.initials: K
authors.lastname: Tanimoto
authors.forename: T
authors.initials: T
authors.lastname: Otsuka
authors.forename: T
authors.initials: T
authors.lastname: Minematsu
authors.forename: Y
authors.initials: Y
authors.lastname: Minamishima
authors.forename: Y
authors.initials: Y
authors.lastname: Niho
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D003586:Cytomegalovirus Infections / Q000188:drug therapy*; D004351:Drug Resistance; D005260:Female; D017245:Foscarnet / Q000627:therapeutic use*; D015774:Ganciclovir / Q000494:pharmacology*; D006525:Hepatitis, Viral, Human / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy
chemical_list: D000998:Antiviral Agents; D017245:Foscarnet; D015774:Ganciclovir