title: Striatal dopamine D1 receptors in narcolepsy: a PET study with [11C]NNC 756.
abstract: We investigated dopamine D1 receptors in the putamen and caudate nucleus with positron emission tomography in six patients with narcolepsy and five healthy controls using [11C]NNC 756 as ligand. The caudate-to-cerebellum and putamen-to-cerebellum ratios of [11C]NNC 756 were within normal limits in patients with narcolepsy. No evidence of increased D1 receptor binding in narcolepsy was found.
authors.affiliation: Department of Neurology, University of Turku, Finland.
authors.forename: J O
authors.initials: JO
authors.lastname: Rinne
authors.forename: C
authors.initials: C
authors.lastname: Hublin
authors.forename: M
authors.initials: M
authors.lastname: Partinen
authors.forename: H
authors.initials: H
authors.lastname: Ruottinen
authors.forename: K
authors.initials: K
authors.lastname: Någren
authors.forename: P
authors.initials: P
authors.lastname: Lehikoinen
authors.forename: U
authors.initials: U
authors.lastname: Ruotsalainen
authors.forename: A
authors.initials: A
authors.lastname: Laihinen
mesh_terms: D000328:Adult; D001665:Binding Sites; D002421:Caudate Nucleus / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000378:metabolism*; D011699:Putamen / Q000378:metabolism*; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D014055:Tomography, Emission-Computed
chemical_list: D017448:Receptors, Dopamine D2; D004298:Dopamine