Reduction of adhesions with fibrin glue after laparoscopic excision of large ovarian endometriomas.
OBJECTIVE
To evaluate the effect of fibrin glue on the formation of adhesions after laparoscopic excision of endometriomas.


METHODS
Prospective case series.


METHODS
Department of Obstetrics and Gynecology at a university-affiliated hospital.


METHODS
Thirty women with ovarian cysts.


METHODS
In 10 women (16 cysts) we performed laparoscopic resection of endometriomas leaving the ovarian capsule open. Twenty patients (25 cysts) underwent laparoscopic removal of endometriomas and fibrin glue approximation of the ovarian capsule, as well as coating of serosal defects with the glue. At second-look laparoscopy 4 to 6 months after the initial surgery, postoperative adhesion formation was assessed according to the revised American Fertility Society classification.


RESULTS
The mean (+/- SEM) adnexal adhesion score in patients without fibrin glue was 8.6 +/- 2.2 at initial surgery and increased slightly to 12.6 +/- 2.6 at second-look laparoscopy. In patients treated with fibrin glue, the score decreased significantly from 10.9 +/- 1.4 to 7.8 +/- 1.3 (p <0.02). The decrease was most marked in women with endometriomas 5 cm or more in diameter and for those with a preoperative adhesion score of 8 or higher.


CONCLUSIONS
Fibrin glue reduced postoperative adhesions after laparoscopic resection of endometriomas.
Takeuchi
H
H
Department of Obstetrics and Gynecology, Juntendo University School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo 113, Japan.
Awaji
M
M
Hashimoto
M
M
Nakano
Y
Y
Mitsuhashi
N
N
Kuwabara
Y
Y
D004715:Endometriosis / Q000601:surgery*; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage*; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects / Q000379:methods*; D010048:Ovarian Cysts / Q000601:surgery; D010049:Ovarian Diseases / Q000601:surgery*; D011446:Prospective Studies; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control
D015718:Fibrin Tissue Adhesive