The source of urinary nitrosamines in patients with enterocystoplasties.
OBJECTIVE
To assess the factors influencing urinary nitrosamine production in patients with enterocystoplasties.


METHODS
The study comprised 100 patients with an enterocystoplasty, 20 patients with interstitial cystitis, 30 with infective cystitis and 120 control subjects drawn from hospital staff and out-patients. Urinary nitrosamine levels were measured and the urine samples cultured for microorganisms.


RESULTS
Nitrosamine levels were significantly higher only in patients with enterocystoplasties who also had higher urinary white cell counts or significant bacteriuria.


CONCLUSIONS
Patients with an enterocystoplasty and significant bacteriuria are most at risk from potential nitrosamine-induced epithelial injury.
Creagh
T A
TA
Academic Department of Urology, Guy's Hospital, London, UK.
Picramenos
D
D
Smalley
E T
ET
Walters
C L
CL
Mundy
A R
AR
D001437:Bacteriuria / Q000652:urine; D003556:Cystitis / Q000382:microbiology / Q000652:urine*; D018856:Cystitis, Interstitial / Q000652:urine; D006801:Humans; D007958:Leukocyte Count; D009602:Nitrosamines / Q000652:urine*; D014547:Urinary Diversion; D014552:Urinary Tract Infections / Q000652:urine*
D009602:Nitrosamines