title: Metabolic adaptation of terminal ileal mucosa after construction of an ileoanal pouch.
abstract: BACKGROUND
  The major nutrients for the large bowel and small bowel mucosa are, respectively, butyrate and glutamine. The degree of mucosal adaptation that may occur in response to changes in nutrient supply and faecal stasis after the formation of an ileoanal pouch is poorly understood.
  
  
  METHODS
  The ability of ileal mucosal biopsies, from nine patients with ulcerative colitis and from 18 with an ileoanal pouch, to oxidize [14C]-glucose, glutamine and butyrate to carbon dioxide was quantified.
  
  
  RESULTS
  Glucose, glutamine and butyrate were oxidized respectively at a median of 12.5 (95 per cent confidence interval (4-22), 77 (34-207) and 194 (81-321) pmol microgram-1 h-1 by ileal mucosa and 12.9 (6-21), 35 (11-57) and 194 (73-737) pmol microgram-1 h-1 by pouch mucosa.
  
  
  CONCLUSIONS
  Ileoanal pouch construction and subsequent bacterial colonization and faecal stasis resulted in a significant (P < 0.05) reduction in the mucosal ability to oxidize glutamine whereas there was no difference in the rate of butyrate oxidation.
authors.affiliation: Department of Surgery, London Hospital Medical School, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: Chapman
authors.forename: M
authors.initials: M
authors.lastname: Hutton
authors.forename: M F
authors.initials: MF
authors.lastname: Grahn
authors.forename: N S
authors.initials: NS
authors.lastname: Williams
mesh_terms: D000328:Adult; D000368:Aged; D002087:Butyrates / Q000378:metabolism*; D020148:Butyric Acid; D003093:Colitis, Ulcerative / Q000378:metabolism* / Q000601:surgery; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005973:Glutamine / Q000378:metabolism*; D006801:Humans; D007082:Ileum / Q000378:metabolism*; D007413:Intestinal Mucosa; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D016737:Proctocolectomy, Restorative
chemical_list: D002087:Butyrates; D005973:Glutamine; D020148:Butyric Acid; D005947:Glucose