Predictors of the rate of renal function decline in non-insulin-dependent diabetes mellitus.
A multivariate analysis of 263 Mexican-American, African-American, and Non-Hispanic white non-insulin-dependent diabetes mellitus patients with end-stage renal disease revealed that in subjects following a linear course of decline of renal function, Mexican-American ethnicity (p = 0.0503) and female sex (p = 0.0036) hasten the rate of decline of renal function, while age (p = 0.0004), hypertension duration (p = 0.0058), and diabetes duration (p = 0.0587) slow the rate of decline of renal function. Blood pressure and glycemic control do not predict the rate of decline. These data suggest that ethnicity and sex-related factors may be as important as blood pressure and glycemic control during the course of non-insulin-dependent diabetic nephropathy.
Garza
R
R
University of Texas Health Science Center at San Antonio, USA.
Medina
R
R
Basu
S
S
Pugh
J A
JA
D000367:Age Factors; D044383:Black People; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000208:ethnology*; D003928:Diabetic Nephropathies / Q000208:ethnology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D006973:Hypertension / Q000208:ethnology; D007676:Kidney Failure, Chronic / Q000208:ethnology* / Q000209:etiology; D008297:Male; D017058:Mexican Americans; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D012737:Sex Factors; D044465:White People; D001741:Black or African American