title: [Synthesis and expression of transforming growth factor-beta in activated macrophages].
abstract: It has been established that once macrophages become activated, they pass through different stages of functional activity. Mouse macrophages activated by BCG "exerted" pronounced cytotoxic effects for 2-5 days to be followed later by growth-stimulating ones. However, in other experiments, the cytotoxic effect was either absent or occurred at later stages which was probably due to a certain functional state of macrophages before activation. The synthesis of TGF-beta increased 1-2 days after activation with BCG vaccine, lipopolysacharide and gamma radiation. An increase in mRNA TGF-beta i expression was observed only 5 days after activation of macrophages.
authors.forename: S G
authors.initials: SG
authors.lastname: Zubova
authors.forename: A O
authors.initials: AO
authors.lastname: Danilov
authors.forename: V B
authors.initials: VB
authors.lastname: Okulov
authors.forename: D F
authors.initials: DF
authors.lastname: Kiagulov
authors.forename: I I
authors.initials: II
authors.lastname: Stiuf
authors.forename: A I
authors.initials: AI
authors.lastname: Zaritskiĭ
mesh_terms: D000818:Animals; D005720:Gamma Rays; D008070:Lipopolysaccharides; D008262:Macrophage Activation; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D009163:Mycobacterium bovis; D016212:Transforming Growth Factor beta / Q000096:biosynthesis*
chemical_list: D008070:Lipopolysaccharides; D016212:Transforming Growth Factor beta
vernacular_title: Sintez i èkspressiia transformiruiushchego faktora rosta-beta aktivirovannymi makrofagami.