title: 13C editing of glutamate in human brain using J-refocused coherence transfer spectroscopy at 4.1 T.
abstract: The method of single quantum 13C editing is analyzed and implemented with water suppressed J-refocused coherence transfer spectroscopy. Analysis of the 13C inversion pulse demonstrates that it is optimally placed into the second echo of the J-refocused sequence. We have used this method to acquire 13C-edited spectra of glutamate from phantoms and in vivo. The turnover of 13C4-labeled glutamate in human brain in vivo was observed in parasagittal gray matter using a volume head coil at 4.1 T with a time resolution of 5.3 min.
authors.affiliation: Department of Neurology, University of Alabama at Birmingham 35294, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Pan
authors.forename: G F
authors.initials: GF
authors.lastname: Mason
authors.forename: J T
authors.initials: JT
authors.lastname: Vaughan
authors.forename: W J
authors.initials: WJ
authors.lastname: Chu
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: H P
authors.initials: HP
authors.lastname: Hetherington
mesh_terms: D001921:Brain / Q000378:metabolism*; D002247:Carbon Isotopes; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*
chemical_list: D002247:Carbon Isotopes; D018698:Glutamic Acid