Mammalian germ cell mutagenicity of ENU, IPMS and MMS, chemicals selected for a transgenic mouse collaborative study.
A collaborative study to systematically assess transgenic mouse mutation assays as screens for germ cell mutagens has been conducted. Three male mouse germ cell mutagens (ENU, iPMS and MMS) were selected for testing. This paper provides a brief review of the effects reported for those 3 chemicals in the most commonly used non-transgenic germ cell mutagenicity assays, namely the dominant lethal, heritable translocation, and specific locus tests. Additionally, information on the DNA reactivity and the molecular nature of mutations induced by these chemicals is summarized.
Shelby
M D
MD
Reproductive Toxicology Group, NIEHS, Research Triangle Park, NC 27709, USA.
Tindall
K R
KR
D000818:Animals; D005038:Ethylnitrosourea / Q000633:toxicity*; D018095:Germ-Line Mutation; D008297:Male; D008698:Mesylates / Q000633:toxicity*; D008741:Methyl Methanesulfonate / Q000633:toxicity*; D051379:Mice; D008822:Mice, Transgenic; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*
D008698:Mesylates; D009153:Mutagens; D008741:Methyl Methanesulfonate; D005038:Ethylnitrosourea; C002531:isopropylmethanesulfonate