title: Antimicrobial susceptibility of Streptococcus pneumoniae isolated from pediatric carriers in Spain.
abstract: The in vitro activity of several beta-lactam agents, macrolides, and cotrimoxazole was investigated against 53 Streptococcus pneumoniae isolates recovered from healthy children. The rates of resistance to penicillin or amoxicillin, cefaclor, and cefuroxime were 30%, 51%, and 37%, respectively. No cefotaxime-resistant isolates were found. Rates of resistance to erythromycin, clarithromycin, and cotrimoxazole were 22.6%, 13.2%, and 83%, respectively. Pneumococci with divergent antimicrobial susceptibility profiles (susceptible or moderately resistant vs. resistant isolates) coexisted in 32% samples, with divergencies more often involving beta-lactam agents and/or macrolides. In five of these samples, isolates belonged to different serotypes.
authors.affiliation: Department of Microbiology, School of Medicine, University Hospital, Valencia, Spain.
authors.forename: J
authors.initials: J
authors.lastname: García-de-Lomas
authors.forename: C
authors.initials: C
authors.lastname: Gimeno
authors.forename: E
authors.initials: E
authors.lastname: Millás
authors.forename: M
authors.initials: M
authors.lastname: Bermejo
authors.forename: M A
authors.initials: MA
authors.lastname: Lázaro
authors.forename: D
authors.initials: D
authors.lastname: Navarro
authors.forename: L
authors.initials: L
authors.lastname: García-Ponte
authors.forename: B
authors.initials: B
authors.lastname: Garijo
mesh_terms: D000293:Adolescent; D000658:Amoxicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002353:Carrier State / Q000382:microbiology*; D002433:Cefaclor / Q000494:pharmacology; D002444:Cefuroxime / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D017291:Clarithromycin / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000494:pharmacology; D006801:Humans; D007223:Infant; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology; D013030:Spain; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D004917:Erythromycin; D002433:Cefaclor; D000658:Amoxicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D017291:Clarithromycin; D002444:Cefuroxime