title: Cardiac risk stratification in renal transplantation using a form of artificial intelligence.
abstract: The purpose of this study was to determine if an expert network, a form of artificial intelligence, could effectively stratify cardiac risk in candidates for renal transplant. Input into the expert network consisted of clinical risk factors and thallium-201 stress test data. Clinical risk factor screening alone identified 95 of 189 patients as high risk. These 95 patients underwent thallium-201 stress testing, and 53 had either reversible or fixed defects. The other 42 patients were classified as low risk. This algorithm made up the "expert system," and during the 4-year follow-up period had a sensitivity of 82%, specificity of 77%, and accuracy of 78%. An artificial neural network was added to the expert system, creating an expert network. Input into the neural network consisted of both clinical variables and thallium-201 stress test data. There were 5 hidden nodes and the output (end point) was cardiac death. The expert network increased the specificity of the expert system alone from 77% to 90% (p < 0.001), the accuracy from 78% to 89% (p < 0.005), and maintained the overall sensitivity at 88%. An expert network based on clinical risk factor screening and thallium-201 stress testing had an accuracy of 89% in predicting the 4-year cardiac mortality among 189 renal transplant candidates.
authors.affiliation: Department of Radiology, Oregon Health Sciences University, Portland 97201, USA.
authors.forename: T F
authors.initials: TF
authors.lastname: Heston
authors.forename: D J
authors.initials: DJ
authors.lastname: Norman
authors.forename: J M
authors.initials: JM
authors.lastname: Barry
authors.forename: W M
authors.initials: WM
authors.lastname: Bennett
authors.forename: R A
authors.initials: RA
authors.lastname: Wilson
mesh_terms: D000328:Adult; D001185:Artificial Intelligence; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006331:Heart Diseases / Q000175:diagnosis / Q000401:mortality; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013794:Thallium Radioisotopes
chemical_list: D013794:Thallium Radioisotopes