title: Recurrent type I membranoproliferative glomerulonephritis after renal transplantation and protective role of cyclosporine in acute crescentic transformation.
abstract: Almost all diseases affecting the native kidney may recur in the transplanted kidney, with one of the most frequent being recurrent glomerulonephritis. Among the glomerulonephritides, membranoproliferative glomerulonephritis (MPGN), immunoglobulin A nephropathy (IgA), and focal-segmental glomerulosclerosis (FSGS) have the highest rates of recurrence. Here we report a patient who, after living-related kidney transplantation, suffered allograft loss shortly after surgery due to recurrence of glomerulonephritis. Two weeks prior to transplant nephrectomy light microscopic examination of the allograft biopsy failed to show glomerulonephritis. Subsequent histopathology of the transplant nephrectomy specimen demonstrated a crescentic form of type I MPGN following withdrawal of cyclosporin A (CsA) and intense course or oral steroid therapy. The entity of recurrent type I MPGN in kidney transplantation is reviewed, and a possible protective role of CsA against rapidly progressive crescentic type I MPGN is explored.
authors.affiliation: Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University - College of Medicine, Hershey 17033, USA.
authors.forename: N
authors.initials: N
authors.lastname: Ahsan
authors.forename: E C
authors.initials: EC
authors.lastname: Manning
authors.forename: D J
authors.initials: DJ
authors.lastname: Dabbs
authors.forename: R R
authors.initials: RR
authors.lastname: Gifford
authors.forename: H C
authors.initials: HC
authors.lastname: Yang
mesh_terms: D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000473:pathology / Q000601:surgery*; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007668:Kidney / Q000473:pathology; D016030:Kidney Transplantation; D019520:Living Donors; D008875:Middle Aged; D012008:Recurrence
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine