title: Hydroxyapatite and fluorapatite coatings for fixation of weight loaded implants.
abstract: Survivor analysis of total hip replacement recently has shown disappointing results in younger patients. To improve this, ceramic coatings have been applied to prostheses for cementless use. A new fluorine containing coating, fluorapatite, has been shown to increase bone ingrowth compared with hydroxyapatite in unloaded models. In a weight loaded model, the effects of hydroxyapatite and fluorapatite coated implants on implant fixation and bone ingrowth were evaluated. Eight hydroxyapatite and fluorapatite coated implants with porous surface were inserted into the medial femoral condyles of 8 mature dogs in a paired design. The implants initially were surrounded by a gap communicating with the joint space and were loaded during each gait cycle. After 25 weeks, no differences in pushout data or bone ingrowth between hydroxyapatite and fluorapatite coated implants were found. An important finding was the absence of foreign body reaction in the bone. Neither hydroxyapatite nor fluorapatite coatings delaminated during implantation or as a result of the pushout test. Bone repair activity remained in the initial gap zone, but most of the bone was of the lamellar type. No difference in bone remodeling between the hydroxyapatite and fluorapatite coated implants was found in the initial gap zone. Microprobe analysis showed no increase in fluorine content around the fluorapatite coated implants. The hydroxyapatite and fluorapatite coatings seem efficacious after a 25-week implantation period under weight loaded conditions.
authors.affiliation: Department of Orthopaedics, Orthopaedic Hospital, Aarhus, Denmark.
authors.forename: S
authors.initials: S
authors.lastname: Overgaard
authors.forename: M
authors.initials: M
authors.lastname: Lind
authors.forename: H
authors.initials: H
authors.lastname: Glerup
authors.forename: S
authors.initials: S
authors.lastname: Grundvig
authors.forename: C
authors.initials: C
authors.lastname: Bünger
authors.forename: K
authors.initials: K
authors.lastname: Søballe
mesh_terms: D000818:Animals; D001031:Apatites / Q000627:therapeutic use*; D001672:Biocompatible Materials / Q000627:therapeutic use*; D016723:Bone Remodeling; D004285:Dogs; D017886:Durapatite / Q000627:therapeutic use*; D005069:Evaluation Studies as Topic; D016348:Osseointegration; D019736:Prostheses and Implants
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; D017886:Durapatite; C025105:fluorapatite