title: Effect of Azadirachta indica hydroalcoholic leaf extract on the cardiovascular system.
abstract: 1. The effect of Azadirachta indica hydroalcoholic leaf extract on the cardiovascular system was studied. 2. The leaf extract was found to reduce a dose-dependent hypotensive effect without altering the amplitude or rate of respiration. 3. In isolated frog heart, there was no noticeable change in amplitude of contraction or rate of the heart at lower doses of leaf extract. However, at higher doses, there was temporary cardiac arrest in diastole. 4. The results are discussed.
authors.affiliation: Biometry Research Unit, Indian Statistical Institute, Calcutta, India.
authors.forename: R R
authors.initials: RR
authors.lastname: Chattopadhyay
mesh_terms: D000818:Animals; D001001:Anura; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D008515:Medicine, Ayurvedic; D009200:Myocardial Contraction / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal
chemical_list: D010936:Plant Extracts