[Role of fungi belonging to the genus Candida in the etiology of nonspecific pulmonary diseases].
The sputum specimens from 1363 patients at the age of 16 to 65 years with nonspecific pulmonary diseases and the pleural exudate specimens from 325 patients were tested for fungi in 1989-1994. The etiological significance of Candida was stated at a concentration of > 10(5) GFU per 1 ml of the sputum. The identification was performed by the routine methods. An increase in the rate of the fungi isolation was studied in the time course of the observation: 15.3 +/- 1.9 per cent in 1989 and 31.6 +/- 3.4 per cent in 1994. The fungi were more frequently isolated from the patients with lung abscesses (38.0 +/- 4.1 per cent of the cases). In the patients with pyothorax the fungi were isolated from the pleural exudate specimens only in 6.8 +/- 1.4 per cent of the cases. The groups of risk of the susceptibility to Candida were revealed. They included patients at the age of 21 to 30 years and above 60. Out of 484 Candida isolates 80.7 per cent belonged to C. albicans, 4.2 per cent to C. tropicalis, 2.1 per cent to C. kefyr and 1.8 per cent to C. krusei. The isolates of C. parapsilosis, C. guillermoudii, C. utilis and C. brumptii were rate. The isolates were highly susceptible to nystatin (91,8 per cent) and lowly susceptible to levorin (35.4 per cent), amphoglucamine (24.7 per cent) and ketokonazol (16.8 per cent).
Bahukova
T A
TA
Dobrodeeva
L K
LK
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000666:Amphotericin B / Q000031:analogs & derivatives / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D002174:Candicidin / Q000627:therapeutic use; D002175:Candida / Q000187:drug effects / Q000302:isolation & purification*; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use; D008172:Lung Diseases, Fungal / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009761:Nystatin / Q000627:therapeutic use; D012189:Retrospective Studies; D013183:Sputum / Q000382:microbiology
D000935:Antifungal Agents; D009761:Nystatin; D002174:Candicidin; C023999:amphoglucamine; D000666:Amphotericin B; D007654:Ketoconazole
Rol' gribov roda Candida v étiologii nespetsificheskikh zabolevaniĭ legkikh.