Pentavalent 99mTc DMSA: uptake into a variety of human rhabdomyosarcoma xenografts.
BACKGROUND
Rhabdomyosarcoma is a common soft tissue sarcoma of childhood. While Ga is currently the most accurate modality for imaging residual or recurrent tumour its dosimetry is unfavourable. Pentavalent 99mTc DMSA [99mTc (V) DMSA] has been shown to accumulate in this tumour in a limited number of clinical cases.


METHODS
Biodistribution of 99mTc (V) DMSA was determined in non-tumour bearing BALB-C mice. Operative specimens from four clinically 67Ga avid tumours were xenografted into nude mice and allowed to reach a significant size. Biodistribution studies were performed after the injection of 99mTc (V) DMSA in all animals and 125I HSA and 67Ga in a limited number of animals.


RESULTS
None of the tumours investigated demonstrated significant 99mTc (V) DMSA accumulation. Biodistribution was identical in tumour and non-tumour bearing animals.


CONCLUSIONS
Rhabdomyo-sarcoma xenografts do not demonstrate significant uptake of 99mTc (V) DMSA.
Van der Wall
H
H
Department of Nuclear Medicine, Prince of Wales Hospital, Sydney, Australia.
Henderson
D
D
Baker
R
R
Murray
I P
IP
D000418:Albumins / Q000493:pharmacokinetics; D000818:Animals; D002648:Child; D005710:Gallium Radioisotopes / Q000493:pharmacokinetics; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D007700:Kinetics; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D012208:Rhabdomyosarcoma / Q000000981:diagnostic imaging*; D004113:Succimer / Q000493:pharmacokinetics; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D014018:Tissue Distribution; D014183:Transplantation, Heterologous
D000418:Albumins; D005710:Gallium Radioisotopes; D007457:Iodine Radioisotopes; D015609:Organotechnetium Compounds; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D004113:Succimer