The use of SPECT in a multidisciplinary memory clinic.
We tested the interobserver reliability of visual rating of HMPAO-SPECT imaging in 271 outpatients referred to a memory clinic, and followed over 1 year. The clinical diagnoses were Alzheimer's disease (n = 156), frontotemporal dementia (n = 47); vascular dementia (n = 21), senile dementia of Lewy body type (n = 12), anxiety/depressive disorders (n = 14) and miscellaneous memory disorders (n = 21). The interobserver agreement was good (k = 0.68). However, the heterogeneity of the patterns-independent from demographic data, age at onset and duration of the disease- and their lack of sensibility and specificity limited the contribution of SPECT for diagnostic purposes in routine practice.
Pasquier
F
F
Department of Neurology, University Hospital, Lille, France.
Lavenu
I
I
Lebert
F
F
Jacob
B
B
Steinling
M
M
Petit
H
H
D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging; D001923:Brain Chemistry / Q000502:physiology; D003704:Dementia / Q000000981:diagnostic imaging; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000000981:diagnostic imaging*; D015588:Observer Variation; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D013702:Temporal Lobe / Q000000981:diagnostic imaging; D015899:Tomography, Emission-Computed, Single-Photon
D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime