ERM proteins: head-to-tail regulation of actin-plasma membrane interaction.
ERM (ezrin/radixin/moesin) proteins crosslink actin filaments with plasma membranes. The carboxyl termini of these proteins bind actin filaments, while the amino termini bind plasma membranes using a binding partner, such as CD44. Specific signals activate ERM proteins to bind actin filaments and the plasma membrane; these include phosphoinositides and/or phosphorylation mechanisms, which might be located downstream from the Rho-dependent pathway.
Tsukita
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College of Medical Technology, Kyoto University, Japan. atsukita@mfour.med.kyoto-u.ac.jp
Yonemura
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Tsukita
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D000199:Actins / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D003598:Cytoskeletal Proteins; D003599:Cytoskeleton / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D009479:Neuropeptides; D010802:Phylogeny; D012234:Rho Factor / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism*
D000199:Actins; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins; D008565:Membrane Proteins; D009479:Neuropeptides; D012234:Rho Factor; D014157:Transcription Factors; C028841:erythrocyte membrane band 4.1 protein; C120557:erythrocyte membrane protein band 4.1-like 1