Dysregulation of bcl-2, c-myc, and Fas expression during tricyclic antidepressant-induced apoptosis in human peripheral lymphocytes.
Tricyclic antidepressants (TCAs) have been shown to induce apoptosis in human lymphocytes. In the present report, we investigated in parallel the regulation of the three oncogenes bcl-2, c-myc, and Fas. A reduction in c-myc and bcl-2 levels of 35-40% and 22-27%, respectively, was observed. On the other hand, Fas expression on the outer surface of the plasma membrane was increased up to 31%. In conclusion, bcl-2, c-myc, and Fas are undergoing dysregulation due to TCA-induced apoptosis.
Xia
Z
Z
Unit for Biochemical Toxicology, Wallenberg Laboratory, University of Stockholm, Sweden.
DePierre
J W
JW
Nässberger
L
L
D000929:Antidepressive Agents, Tricyclic / Q000633:toxicity*; D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D015283:Citalopram / Q000633:toxicity; D002997:Clomipramine / Q000633:toxicity; D005786:Gene Expression Regulation / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D007099:Imipramine / Q000633:toxicity; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000378:metabolism; D019014:fas Receptor / Q000235:genetics / Q000378:metabolism
D000929:Antidepressive Agents, Tricyclic; D019253:Proto-Oncogene Proteins c-bcl-2; D016271:Proto-Oncogene Proteins c-myc; D019014:fas Receptor; D015283:Citalopram; D002997:Clomipramine; D007099:Imipramine