title: Response programming in dementia of the Alzheimer type: a kinematic analysis.
abstract: Although planning is important for the functioning of patients with dementia of the Alzheimer Type (DAT), little is known about response programming in DAT. This study used a cueing paradigm coupled with quantitative kinematic analysis to document the preparation and execution of movements made by a group of 12 DAT patients and their age and sex matched controls. Participants connected a series of targets placed upon a WACOM SD420 graphics tablet, in response to the pattern of illumination of a set of light emitting diodes (LEDs). In one condition, participants could programme the upcoming movement, whilst in another they were forced to reprogramme this movement on-line (i.e. they were not provided with advance information about the location of the upcoming target). DAT patients were found to have programming deficits, taking longer to initiate movements, particularly in the absence of cues. While problems spontaneously programming a movement might cause a greater reliance upon on-line guidance, when both groups were required to guide the movement on-line, DAT patients continued to show slower and less efficient movements implying declining sensori-motor function; these differences were not simply due to strategy or medication status.
authors.affiliation: Department of Psychology, Monash University, Clayton, Victoria, Australia.
authors.forename: M A
authors.initials: MA
authors.lastname: Bellgrove
authors.forename: J G
authors.initials: JG
authors.lastname: Phillips
authors.forename: J L
authors.initials: JL
authors.lastname: Bradshaw
authors.forename: K A
authors.initials: KA
authors.lastname: Hall
authors.forename: I
authors.initials: I
authors.lastname: Presnell
authors.forename: H
authors.initials: H
authors.lastname: Hecht
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000503:physiopathology*; D000704:Analysis of Variance; D016022:Case-Control Studies; D003463:Cues; D005260:Female; D006801:Humans; D008297:Male; D009069:Movement Disorders / Q000209:etiology*; D011596:Psychomotor Disorders / Q000209:etiology*; D011930:Reaction Time; D014836:Volition / Q000502:physiology*