title: Body iron stores are associated with serum insulin and blood glucose concentrations. Population study in 1,013 eastern Finnish men.
abstract: OBJECTIVE
  To study if there is an association between mildly elevated body iron and glucose homeostasis indexes.
  
  
  METHODS
  A cross-sectional population study was conducted in 1,013 middle-aged men, and an association of serum ferritin with concentrations of serum insulin, blood glucose, and serum fructosamine was tested.
  
  
  RESULTS
  The mean concentration of fasting serum insulin was 21.6% higher (95% CI 7.3-37.9%, P < 0.001) in the 5th quintile of serum ferritin compared with the 1st quintile. The elevation in blood glucose was 6.1% (95% CI 2.3-9.9%, P < 0.001) and in serum fructosamine 3.9% (1.5-6.9%, P < 0.01).
  
  
  CONCLUSIONS
  Mildly elevated body iron stores are associated with statistically significant elevations in glucose homeostasis indexes.
authors.affiliation: Research Institute of Public Health, University of Kuopio, Finland.
authors.forename: T P
authors.initials: TP
authors.lastname: Tuomainen
authors.forename: K
authors.initials: K
authors.lastname: Nyyssönen
authors.forename: R
authors.initials: R
authors.lastname: Salonen
authors.forename: A
authors.initials: A
authors.lastname: Tervahauta
authors.forename: H
authors.initials: H
authors.lastname: Korpela
authors.forename: T
authors.initials: T
authors.lastname: Lakka
authors.forename: G A
authors.initials: GA
authors.lastname: Kaplan
authors.forename: J T
authors.initials: JT
authors.lastname: Salonen
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis* / Q000378:metabolism; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000209:etiology; D005215:Fasting; D005293:Ferritins / Q000097:blood* / Q000378:metabolism; D005387:Finland; D005500:Follow-Up Studies; D019270:Fructosamine / Q000097:blood; D005951:Glucose Tolerance Test; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D007328:Insulin; D019270:Fructosamine; D005293:Ferritins