[The effect of phenol on the ion currents of the frog motor nerve ending].
Phenol was shown to enhance the quantum content of the end-plate currents and to increase the duration of the nerve ending response. The effect could be abolished by the potassium channel blockers. The data obtained suggest that alteration of the kinetics of the potential-dependent potassium current of the nerve terminal is one of the mechanisms of the phenol facilitating effect on neuro-muscular transmission.
Sitdikova
G F
GF
Khalilov
I A
IA
Zefirov
A L
AL
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology; D003472:Curare / Q000037:antagonists & inhibitors; D004558:Electric Stimulation; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects* / Q000502:physiology; D008839:Microelectrodes; D009045:Motor Endplate / Q000187:drug effects* / Q000502:physiology; D019800:Phenol; D010636:Phenols / Q000494:pharmacology*; D017729:Presynaptic Terminals / Q000187:drug effects* / Q000502:physiology; D011895:Rana ridibunda; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
D002121:Calcium Channel Blockers; D007473:Ion Channels; D010636:Phenols; D019800:Phenol; D003472:Curare
Vliianie fenola na ionnye toki dvigatel'nogo nervnogo okonchaniia liagushki.