title: Studies on the synthesis and biological activity of 3-(substituted anilinomethyl)-4-(5-substituted-2-furfurylidene)amino-1,2,4 -triazole-5- thiones and their Mannich bases.
abstract: A series of 3-(substituted anilinomethyl)-4-(5-substituted-2- furfurylidene)amino-1,2,4-triazole-5-thiones were synthesized as potential biologically active agents. They were converted to Mannich bases, by treating with suitable amine in the presence of formaldehyde in alcohol medium. The newly synthesized compounds were screened for their antibacterial and antifungal activities.
authors.affiliation: Department of Studies in Chemistry, Mangalore University, Mangalagangothri, India.
authors.forename: B
authors.initials: B
authors.lastname: Kalluraya
authors.forename: S N
authors.initials: SN
authors.lastname: Shetty
authors.forename: P
authors.initials: P
authors.lastname: Gunaga
authors.forename: B S
authors.initials: BS
authors.lastname: Holla
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D008352:Mannich Bases / Q000138:chemical synthesis; D008826:Microbial Sensitivity Tests; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D008352:Mannich Bases; D014230:Triazoles