Abnormal expression of the p53 tumor suppressor gene in the conjunctiva of patients with pterygium.
OBJECTIVE
To determine whether pterygium is a disorder of abnormal growth by examining the expression of the p53 gene in the conjunctiva of patients with pterygium.


METHODS
Immunostaining for abnormal expression of p53 was performed using mouse monoclonal antibody to human p53, pAb 240, on six eyes with primary pterygium and two eyes with recurrent pterygium.


RESULTS
In three of the eight eyes with pterygium, specimens were positive for abnormal expression in the epithelium of the pterygium and in the superior bulbar conjunctiva.


CONCLUSIONS
Abnormal p53 expression in the epithelium of primary and recurrent pterygium specimens suggests that pterygium is a growth disorder rather than a degeneration.
Tan
D T
DT
Singapore National Eye Centre, Republic of Singapore. snecdt@pacific.net.sg
Lim
A S
AS
Goh
H S
HS
Smith
D R
DR
D000911:Antibodies, Monoclonal; D003228:Conjunctiva / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D015870:Gene Expression; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D007124:Immunoenzyme Techniques; D011625:Pterygium / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D016159:Tumor Suppressor Protein p53