Mouse embryonal carcinoma cell-somatic cell hybrids as experimental tools for the study of cell differentiation and X chromosome activity.
Remarkable properties of murine embryonal carcinoma cells, stem cells of teratocarcinomas, manifest themselves when they are fused with differentiated somatic cells. Among others the capacity to reprogram genomes from these somatic cells and restore genetic pluripotency is most striking.
Takagi
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Division of Bioscience, Hokkaido University, Sapporo, Japan.
D000818:Animals; D018236:Carcinoma, Embryonal / Q000235:genetics* / Q000473:pathology; D002454:Cell Differentiation / Q000235:genetics*; D019175:DNA Methylation; D004171:Diploidy; D004303:Dosage Compensation, Genetic; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells / Q000473:pathology; D051379:Mice; D010641:Phenotype; D013045:Species Specificity; D014960:X Chromosome / Q000235:genetics*