[The role of glycosaminoglycans and proteoglycans in hemopoiesis and the physiological functions of the blood cells].
Literature review as well as own data on the role of glycosaminoglycans and proteoglycans of leukocytes, platelets and hemopoietic microenvironment are presented. These compounds are involved in the storage of lysosomal enzymes, cationic antibacterial polypeptides and other granular constituents of blood cells, take part in mediating of cellular interactions, occurring in hematopoiesis, phagocytosis, immunity and other processes. Due to the capacity to react with many substances, including enzymes, cell growth factors, cytokines, receptors, changing their conformation and biological activity glycosaminoglycans and proteoglycans can take part in regulation of cell adhesion, migration, proliferation differentiation and special functions of various types of hematopoietic and lymphoid cells.
Kharchenko
M F
MF
Rybakova
L P
LP
Golenko
O D
OD
Kornilova
N V
NV
Zakharov
Iu M
IuM
D000818:Animals; D001773:Blood Cells / Q000502:physiology*; D002450:Cell Communication; D002454:Cell Differentiation; D002455:Cell Division; D006025:Glycosaminoglycans / Q000502:physiology*; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology; D011509:Proteoglycans / Q000502:physiology*
D006025:Glycosaminoglycans; D011509:Proteoglycans
Rol' glikozaminoglikanov i proteoglikanov v gemopoéze i fiziologicheskikh funktsiiakh kletok krovi.