Evaluation of mercaptoalkyl derivatives of imidazolidine-4-one as potential antioxidants and free radical scavengers.
Mercaptoalkyl derivatives of 5,5-diphenyl- and 5-arylidene hydantoins were synthesized as the result of hydrolytic cleavage of bicyclic imidazothiazoles, -thiazines, and -thiazepines. The title compounds were evaluated as potential antioxidants and free radical scavengers using the enzymic generation of O2- and non-enzymic lipid peroxidation tests. Examined compounds were inactive in both applied tests, where reference substances (flavonoids, nitric oxide donors and Ticlopidine) inhibited non-enzymic lipid peroxidation and scavenged superoxide anions.
Kieć-Kononowicz
K
K
Zakład Technologii Chemicznej Srodków Leczniczych, Collegium Medicum, Uniwersytet Jagielloński, Kraków, Polska.
Robak
J
J
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002855:Chromatography, Thin Layer; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000494:pharmacology; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008315:Malondialdehyde / Q000378:metabolism; D013058:Mass Spectrometry; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D013055:Spectrophotometry, Infrared; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism
D000975:Antioxidants; D016166:Free Radical Scavengers; D007093:Imidazoles; D013438:Sulfhydryl Compounds; D013481:Superoxides; D008315:Malondialdehyde