Anti-Ro(SS-A) antibody positive Sjögren's/lupus erythematosus overlap syndrome.
Unlike anti-Ro(SS-A) antibody positive subacute cutaneous lupus erythematosus (SCLE) patients, anti-Ro(SS-A) antibody positive lupus patients with Sjögren's syndrome (SS/LE) appear to have a more guarded prognosis. Our studies indicate these SS/LE patients have an increased frequency of pulmonary, neurological, and renal disease compared to SCLE patients.
Provost
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Johns Hopkins University School of Medicine, Department of Dermatology, Baltimore, Maryland, USA.
Watson
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Simmons-O'Brien
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D000293:Adolescent; D000328:Adult; D000368:Aged; D001168:Arthritis / Q000209:etiology / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D001324:Autoantigens / Q000276:immunology*; D002493:Central Nervous System Diseases / Q000209:etiology / Q000276:immunology; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000209:etiology / Q000276:immunology; D008178:Lupus Erythematosus, Cutaneous / Q000150:complications / Q000276:immunology*; D008875:Middle Aged; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins / Q000276:immunology*; D012859:Sjogren's Syndrome / Q000150:complications / Q000276:immunology*; D016463:Sweet Syndrome / Q000209:etiology / Q000276:immunology; D014657:Vasculitis / Q000209:etiology / Q000276:immunology; D000099207:SS-A Antigen
D001323:Autoantibodies; D001324:Autoantigens; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C116006:RO60 protein, human