title: Direct-coupled interstitial ultrasound applicators for simultaneous thermobrachytherapy: a feasibility study.
abstract: This study presents the design and performance evaluation of interstitial ultrasound applicators designed specifically for thermal therapy with simultaneous brachytherapy. The applicator consists of a multielement array of piezoceramic tubular radiators, each with separate power control, surrounded by thin layers of electrically-insulating and biocompatible coatings (< 2.6 mm OD). A catheter which is compatible with remote afterloaders and standard brachytherapy technology forms the inner lumen. These 'direct-coupled interstitial ultrasound applicators' (DCIUA's) are placed within the tumour or target region, with the coated transducer surface forming the outer wall of the implant catheter. Thermocouple sensors embedded in the coating over each transducer can be used for continuous monitoring of the tissue/applicator interface temperatures for feedback control of power to each transducer segment. Theoretical acoustic power deposition and corresponding temperature distributions from thermal simulations have demonstrated that the radius of effective heating is highly dependent upon the acoustic efficiency of the piezoceramic transducers, with effective heating extending > 1 - 1.5 cm radially for typical DCIUA applicators that are 60-65% efficient. This exceeds the effective heating radius of both thermal conduction and RF heating technologies. Measurements with prototype multielement ultrasound applicators have demonstrated acoustic efficiencies between 60 and 65% and beam distributions which are fairly uniform and collimated to the transducer axial length. Thermal dosimetry measurements within in vivo tissues have demonstrated controllable therapeutic temperature rises at 1 - 1.5 cm radial depth from the applicators, which were in agreement with the simulations. This study demonstrates that direct-coupled ultrasound applicators, designed without an active cooling mechanism in order to accommodate the insertion of radiation sources, are practicable for simultaneous thermobrachytherapy and promises to give more adjustable heating patterns than current alternative techniques.
authors.affiliation: University of California, San Francisco-Radiation Oncology Department, San Francisco, CA 94143-0226, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Diederich
authors.forename: I S
authors.initials: IS
authors.lastname: Khalil
authors.forename: P R
authors.initials: PR
authors.lastname: Stauffer
authors.forename: P K
authors.initials: PK
authors.lastname: Sneed
authors.forename: T L
authors.initials: TL
authors.lastname: Phillips
mesh_terms: D000818:Animals; D001918:Brachytherapy / Q000295:instrumentation*; D002404:Catheterization; D005334:Fever; D008962:Models, Theoretical; D011878:Radiotherapy; D013552:Swine; D013696:Temperature; D014159:Transducers; D014463:Ultrasonography / Q000295:instrumentation / Q000379:methods*