Effect of pre-treatment of some calcium channel blockers on catalepsy and stereotypic behaviour in rats.
Effect of pretreatment of intraperitoneally administered Ca-channel blockers Nifedipine (5, 10, 20 mg/kg). Verapamil (5, 10, 20 mg/kg) and Diltiazem (5, 10, 20 mg/kg) was studied on Haloperidol-induced catalepsy and Methamphetamine-induced stereotypy in albino rats. All these drugs reduced the onset of catalepsy, significantly increased the cataleptic score and delayed the onset and inhibited the Methamphetamine-induced stereotypy. The possible involvement of dopaminergic and adrenergic mechanisms and modification by Ca-channel blockers are discussed.
Khanzode
S D
SD
Department of Pharmacology, Indira Gandhi Government Medical College, Nagpur.
Mahakalkar
S M
SM
Belorkar
N R
NR
Kharkar
V T
VT
Manekar
M S
MS
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002375:Catalepsy / Q000139:chemically induced* / Q000523:psychology; D002492:Central Nervous System Depressants / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D004110:Diltiazem / Q000494:pharmacology; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D009543:Nifedipine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013239:Stereotyped Behavior / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D002492:Central Nervous System Depressants; D000697:Central Nervous System Stimulants; D008694:Methamphetamine; D014700:Verapamil; D004110:Diltiazem; D009543:Nifedipine; D006220:Haloperidol