Simple preparation of nanoparticles coated with carbohydrate-carrying polymers.
Nanoparticles bearing carbohydrate chains on the surface can be prepared by the simple diafiltration method. The nanoparticles prepared by the present method displayed high yield, no-aggregation formation, small size, narrow size distribution, and one-step procedure. Also, the high density carbohydrate chains on the particles can be recognized by liver cells.
Cho
C S
CS
Department of Polymer Engineering, Chonnam National University, Kwangju, Korea.
Jeong
Y I
YI
Ishihara
T
T
Takei
R
R
Park
J U
JU
Park
K H
KH
Maruyama
A
A
Akaike
T
T
D000818:Animals; D002241:Carbohydrates / Q000737:chemistry* / Q000493:pharmacokinetics; D004337:Drug Carriers; D005260:Female; D005434:Flow Cytometry; D019344:Lactic Acid / Q000737:chemistry*; D008099:Liver / Q000378:metabolism*; D008854:Microscopy, Electron; D010316:Particle Size; D011091:Polyesters; D011099:Polyglutamic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013499:Surface Properties
D002241:Carbohydrates; D004337:Drug Carriers; D011091:Polyesters; D011108:Polymers; C003172:poly-gamma-benzyl-L-glutamate; D011099:Polyglutamic Acid; D019344:Lactic Acid; C033616:poly(lactide)