Interspecies comparisons of plasma half-life of trimethoprim in relation to body mass.
The relationship between body mass and plasma half-life of trimethoprim was studied in 10 different species of animals and man using published data. Log half-life was positively and significantly correlated to log body mass based on individual measurements in herbivorous animals (n = 23, P < 0.01), in herbivorous animals+pigs (n = 29, P < 0.01), in ungulates (n = 27, P < 0.01), in ruminants (n = 16, P < 0.01) and in non-herbivorous mammals, except pigs (n = 6, P < 0.05). The correlation was described by the allometric equations: t 1/2 beta = 27 W0.26 in herbivorous animals and t 1/2 beta = 125 W0.32 in non-herbivorous animals except pigs.
Pashov
D A
DA
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Thracian University, Stara Zagora, Bulgaria.
Lashev
L D
LD
Matev
I B
IB
Kanelov
I N
IN
D000818:Animals; D001835:Body Weight / Q000502:physiology*; D002020:Buffaloes; D002417:Cattle; D004285:Dogs; D005493:Folic Acid Antagonists / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006041:Goats; D006207:Half-Life; D006736:Horses; D006801:Humans; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D011817:Rabbits; D051381:Rats; D012016:Reference Values; D012189:Retrospective Studies; D012756:Sheep; D013045:Species Specificity; D013552:Swine; D014295:Trimethoprim / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D005493:Folic Acid Antagonists; D014295:Trimethoprim