The mydriatic effect of tropicamide and its diagnostic use in Alzheimer's disease.
The mydriatic effect of topically administered tropicamide was investigated as a possible diagnostic indicator for Alzheimer's disease. Although an initial series seemed to show a correlation between hypersensitivity to tropicamide and intellectual impairment, subsequent testing showed a greater inter- and intra-individual variation than that between the normal group and the group of patients with intellectual impairment. This procedure seems, therefore, to lack sufficient specificity to be useful for such a diagnostic purpose.
Reitner
A
A
Department of Ophthalmology, University of Vienna, Austria. andreas.Reitner@akh-wien.ac.at
Baumgartner
I
I
Thuile
C
C
Baradaran Dilmaghani
R
R
Ergun
E
E
Kaminski
S
S
Lukas
J
J
Dal Bianco
P
P
D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis*; D003315:Cornea / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D009184:Mydriatics / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects; D015203:Reproducibility of Results; D014331:Tropicamide / Q000494:pharmacology
D009184:Mydriatics; D014331:Tropicamide