title: Colorectal cancer in patients aged 30 years or younger.
abstract: Colorectal cancer (CRC) is believed to carry a grim prognosis in young patients. A retrospective study of patients diagnosed with colorectal cancer at age 30 years or less between 1971 and 1994 was conducted. Statistical analyses were performed using non-parametric one way ANOVA tests and logistic regression models. Sixty-eight of the patients evaluated at our institution were suitable for this study. Risk factors were identified in 28% of patients. The median age at diagnosis was 27 years (range 14-30 years). Fifty-six patients (82%) were Stage III or IV at the time of diagnosis. Twenty-two of the 34 patients who underwent potentially curative surgery had recurring disease at a median of 12 months (range 1-43 months). At a median follow-up of 21.5 months, 54 patients had died from disease. At the time of death, abdominal carcinomatosis and distant disease were the most common patterns of failure. Stage of the primary tumour (P=0.0006) and recurrence (P=0.0001) were the only variables noted to be associated with survival. The stage of the primary tumour and whether the tumour recurred were each associated with survival in patients with colorectal cancer at age 30 years or less.
authors.affiliation: Division of Surgical Oncology and Endoscopy, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Rodriguez-Bigas
authors.forename: M C
authors.initials: MC
authors.lastname: Mahoney
authors.forename: T K
authors.initials: TK
authors.lastname: Weber
authors.forename: N J
authors.initials: NJ
authors.lastname: Petrelli
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D011125:Adenomatous Polyposis Coli / Q000503:physiopathology; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D003093:Colitis, Ulcerative / Q000150:complications; D015179:Colorectal Neoplasms / Q000235:genetics / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D003424:Crohn Disease / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate