title: Distinct central anticholinergic syndrome following general anaesthesia.
abstract: The purpose of this prospective study was to identify the incidence of a distinct central anticholinergic syndrome following routine anaesthesia. For 2 months, all inpatients aged more than 15 years scheduled for elective procedures and cared for in the recovery room were investigated for symptoms of the syndrome. Patients with neuropsychiatric disease or other disorders that could alter consciousness were excluded. Prolonged action of anaesthetics or relaxants, respiratory depression and metabolic disorder were ruled out before making the diagnosis. Out of 962 patients (366 men, 596 women), 18 (4 men, 14 women) developed the syndrome. The difference between men and women was not statistically significant. Six out of 60 women developed the syndrome after a hysterectomy with or without adnectomy/oophorectomy, and this high incidence was significantly different from that observed after all other procedures in women (P = 0.003) or all other gynaecological procedures (P = 0.013). The reason for this is unknown. In six of the 18 cases, untreated prolonged somnolence lasted for more than 2 h. All patients woke up after an injection of physostigmine, but six of them relapsed into somnolence and needed a second, and in one case a third, injection. The findings of the study emphasize that, when there is delayed recovery from anaesthesia, the diagnosis of central anticholinergic syndrome should be considered if other accessible causes for that condition have been excluded.
authors.affiliation: Freie Universität Berlin, Klinikum Benjamin Franklin, Klinik für Anaesthesiologie und Operative Intensivmedizin, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Link
authors.forename: G
authors.initials: G
authors.lastname: Papadopoulos
authors.forename: D
authors.initials: D
authors.lastname: Dopjans
authors.forename: I
authors.initials: I
authors.lastname: Guggenmoos-Holzmann
authors.forename: K
authors.initials: K
authors.lastname: Eyrich
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General / Q000009:adverse effects*; D002493:Central Nervous System Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D018680:Cholinergic Antagonists / Q000009:adverse effects*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010830:Physostigmine / Q000627:therapeutic use; D011183:Postoperative Complications; D011446:Prospective Studies; D013577:Syndrome
chemical_list: D018680:Cholinergic Antagonists; D002800:Cholinesterase Inhibitors; D010830:Physostigmine