title: Dynamics of the HIV-1 subtype distribution in the Swedish HIV-1 epidemic during the period 1980 to 1993.
abstract: We have investigated the distribution of the major subtypes, or clades (A to E), in the Swedish human immunodeficiency virus type 1 (HIV-1) epidemic between the years 1980 to 1993, using gp120 V3 domain serotyping and genotyping. Until 1984 the Swedish HIV-1 epidemic was almost exclusively caused by HIV-1 subtype B. During the late 1980s and the early 1990s an increase in nonsubtype B infections (mainly subtypes A and C) was observed. Nonsubtype B infections constituted approximately 30% of the newly diagnosed HIV-1 cases in 1993. In the analyzed material we also noted a substantial increase in the proportion of HIV-1 infections caused by heterosexual transmission. The present data suggest that the subtype distribution in the Swedish HIV-1 epidemic may well continue to change with time, which may have implications for preventive research and vaccine development strategies.
authors.affiliation: Division of Clinical Virology, Karolinska Institutet, Huddinge University Hospital, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Sönnerborg
authors.forename: S
authors.initials: S
authors.lastname: Durdevic
authors.forename: J
authors.initials: J
authors.lastname: Giesecke
authors.forename: M
authors.initials: M
authors.lastname: Sällberg
mesh_terms: D004279:DNA, Viral / Q000097:blood; D004196:Disease Outbreaks; D015483:HIV Antibodies / Q000097:blood; D015699:HIV Envelope Protein gp120 / Q000145:classification* / Q000235:genetics / Q000276:immunology; D015658:HIV Infections / Q000097:blood / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics / Q000276:immunology; D006801:Humans; D010446:Peptide Fragments / Q000145:classification* / Q000235:genetics / Q000276:immunology; D010802:Phylogeny; D012703:Serotyping; D013548:Sweden
chemical_list: D004279:DNA, Viral; D015483:HIV Antibodies; D015699:HIV Envelope Protein gp120; C059762:HIV envelope protein gp120 (305-321); D010446:Peptide Fragments