title: Expression of the chicken progesterone receptor forms A and B is differentially regulated by estrogen in vivo.
abstract: The chicken progesterone receptor (cPR), like its human counterpart (hPR), exists as two isoforms, PR-A and PR-B, displaying different biological activities depending upon cellular and promoter contexts. Here we show that the ratio of PR isoforms observed in the immature chicken oviduct is changed during estrogen-induced differentiation from PR-B dominancy to that of PR-A. This is the first report describing that the expression ratio of PR isoforms is altered by upregulation of PR-A by estrogen action in vivo. This result provides a plausible explanation to the differences in oviduct's response to progesterone depending on hormonal and developmental status of the animal.
authors.affiliation: Institute of Medical Technology, University of Tampere, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Syvälä
authors.forename: A
authors.initials: A
authors.lastname: Vienonen
authors.forename: T
authors.initials: T
authors.lastname: Ylikomi
authors.forename: M
authors.initials: M
authors.lastname: Bläuer
authors.forename: Y H
authors.initials: YH
authors.lastname: Zhuang
authors.forename: P
authors.initials: P
authors.lastname: Tuohimaa
mesh_terms: D000818:Animals; D015152:Blotting, Northern; D015153:Blotting, Western; D002645:Chickens; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects*; D010057:Oviducts / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics; D011980:Receptors, Progesterone / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D011980:Receptors, Progesterone; D004958:Estradiol