Elevated soluble intercellular adhesion molecules-1 in inflammatory myopathy.
BACKGROUND
We evaluated the serum level of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with polymyositis (PM) and dermatomyositis (DM) and investigated the correlation between the serum level of sICAM-1 and clinical findings.


METHODS
We measured the serum level of sICAM-1 using an enzyme-linked immunosorbent assay in 19 untreated patients with inflammatory myopathy (14 patients with PM and 5 patients with DM), 20 patients with other neuromuscular disorders in which immunological mechanisms are unlikely to be involved, and 14 normal healthy controls.


RESULTS
The serum level of sICAM-1 was significantly higher in patients with PM/DM compared with patients with other neurological disorders and control subjects. The sICAM-1 level was, however, not correlated with the clinical characteristic including disease severity, the duration of illness, and the serum level of CK.


CONCLUSIONS
These findings suggest that sICAM-1 is involved in the inflammatory process of PM and DM.
Kumamoto
T
T
Third Department of Internal Medicine, Oita Medical University, Japan.
Abe
T
T
Ueyama
H
H
Sugihara
R
R
Shigenaga
T
T
Tsuda
T
T
D000328:Adult; D000368:Aged; D003882:Dermatomyositis / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017285:Polymyositis / Q000097:blood*; D012720:Severity of Illness Index
D018799:Intercellular Adhesion Molecule-1