[The role of adenosine in "ischemic preconditioning"].
Repeated short coronary occlusions trigger probably more than one pathway leading to increased tolerance toward ischemia. Adenosine plays probably a very important but not an exclusive role. It may act via opening of A1-receptor-operated K(+)-channels that lead to hyperpolarization of the cell, and it has antiadrenergic actions. A proposed action of adenosine via protein kinase C is not confirmed. Trophic factors are expressed during short periods of ischemia and contribute to survival, probably via inhibition of apoptosis.
Schaper
W
W
Max-Planck-Institut, Abteilung für experimentelle Kardiologie, Bad Nauheim.
Vogt
A
A
Htun
P
P
D000241:Adenosine / Q000502:physiology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D004562:Electrocardiography; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D015221:Potassium Channels / Q000502:physiology; D011493:Protein Kinase C / Q000502:physiology; D018047:Receptors, Purinergic P1 / Q000502:physiology
D015221:Potassium Channels; D018047:Receptors, Purinergic P1; D011493:Protein Kinase C; D000241:Adenosine
Die Rolle von Adenosin bei "ischemic preconditioning".