The effects of a 4.7 tesla static magnetic field on the frequency of micronucleated cells induced by mitomycin C.
The effects of a 4.7 tesla (T) static magnetic field (SMF) on the frequency of micronucleated cells (MN-cells) in CHL/IU cells induced by mitomycin C (MMC) were studied in vitro. Exposure to a 4.7 T SMF for 6 hr significantly decreased the frequency of MMC-induced MN-cells for expression culture periods of 18, 42, 54 and 66 hr. The highest frequency of MMC-induced MN-cells was observed at the expression culture period of 42 hr and decreased gradually in the same manner in both exposed and control groups. These results suggest that a 4.7 T SMF may exert on influence during the DNA damage stage produced by MMC rather than on the formation of micronuclei during the stage following MMC-induced DNA damage.
Okonogi
H
H
Department of Public Health and Environmental Medicine, Jikei University School of Medicine, Tokyo, Japan.
Nakagawa
M
M
Tsuji
Y
Y
D000818:Animals; D002460:Cell Line; D002467:Cell Nucleus / Q000187:drug effects* / Q000648:ultrastructure*; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D004574:Electromagnetic Fields; D016685:Mitomycin / Q000494:pharmacology*; D013997:Time Factors
D016685:Mitomycin