44-Homooligomycin E, a new cytotoxic macrolide antibiotic from Streptomyces ostreogriseus.
Homooligomycin E (1) was isolated from the culture broth of Streptomyces ostreogriseus and its structure was analyzed on the basis of physicochemical and spectroscopic data. It showed strong cytotoxicity against several human tumor cell lines.
Kim
H S
HS
KRIBB, Korea Institute of Science and Technology, Yusung, Taejon, Korea.
Band
H J
HJ
Lee
S Y
SY
Yoo
O J
OJ
Yoo
J C
JC
Kim
Y H
YH
Lee
J J
JJ
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009840:Oligomycins / Q000737:chemistry*; D013302:Streptomyces / Q000737:chemistry*; D014407:Tumor Cells, Cultured
C105048:44-homooligomycin E; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D009840:Oligomycins