[Changes in the sensitivity of the baroreceptor reflex during the development of renal parenchymatous hypertension in waking cats].
Hemodynamic parameters were investigated in experiments with chronically instrumented hypertensive cats. It was shown, that mean arterial pressure level raised by 35%, heart rate decreased by 20% and peripheral resistance raised by 56% in awake hypertensive cats. The study demonstrates that the mean blood pressure raised on the 30th day after hypertension induction, however, baroreflex sensitivity lowered only on the 40th day. The values of the system hemodynamics indices permit considering that the model of hypertension in awake cats has been worked out for the first time.
Rozin
B D
BD
Orlova
Ts R
TsR
Zhigalina
S G
SG
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D017704:Baroreflex / Q000187:drug effects / Q000502:physiology*; D002415:Cats; D004195:Disease Models, Animal; D006439:Hemodynamics / Q000187:drug effects; D006977:Hypertension, Renal / Q000209:etiology / Q000503:physiopathology*; D009599:Nitroprusside / Q000494:pharmacology; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology*
D000959:Antihypertensive Agents; D009599:Nitroprusside
Izmenenie chuvstvitel'nosti baroretseptivnogo refleksa v khode razvitiia renoparenkhimatoznoĭ gipertenzii u bodrstvuiushchikh koshek.