Potent antifungal effects of a new derivative of partricin A in a murine model of cerebral cryptococcosis.
A new member of the polyene family, N-dimethylaminoacetyl-partricin A 2-dimethylaminoethylamide diaspartate (SPA), was investigated and was found to be more effective than amphotericin B (i) in vivo by enhancing mouse resistance to cryptococcal meningoencephalitis and (ii) in vitro by potentiating the anticryptococcal activity of murine microglial cells.
Luna
T
T
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.
Mazzolla
R
R
Romanò
G
G
Blasi
E
E
D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001921:Brain / Q000382:microbiology; D001927:Brain Diseases / Q000188:drug therapy* / Q000382:microbiology; D015169:Colony Count, Microbial; D004305:Dose-Response Relationship, Drug; D005260:Female; D016919:Meningitis, Cryptococcal / Q000188:drug therapy* / Q000382:microbiology; D051379:Mice; D011090:Polyenes / Q000008:administration & dosage / Q000627:therapeutic use
D000935:Antifungal Agents; D011090:Polyenes; C100293:partricin; D000666:Amphotericin B