Effect of several antidepressant drugs on isolated rat vas deferens in vitro.
Imipramine-N-oxide, quinupramine, clomipramine, doxepin, maprotiline, amineptine, amoxapine, mianserin, minaprine, nomifensine, viloxacine, trazodone and lofepramine effects were studied on rat vas deferens responses to noradrenaline. Tissues were prepared in Krebs-Henseleit solution with and without adding cocaine. 17 beta-estradiol and propranolol for blocking neuronal and extraneuronal noradrenaline reuptake. In normal Krebs-Henseleit solution imipramine-N-oxide, nomifensine, viloxacine and lofepramine increased noradrenaline responses, while clomipramine, trazodone and doxepin behaved as competitive antagonists. When adding cocaine, 17 beta-estradiol and propranolol to the solution there was antagonism but no increase in responses.
Velasco
A
A
Department of Pharmacology, Faculty of Medicine, University of Valladolid, Spain.
Hervás
J
J
Carvajal
A
A
Alvarez
F J
FJ
Alamo
C
C
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D001667:Binding, Competitive; D003042:Cocaine / Q000494:pharmacology; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018340:Receptors, Adrenergic, alpha-1 / Q000187:drug effects* / Q000502:physiology; D014649:Vas Deferens / Q000187:drug effects*
D000316:Adrenergic alpha-Agonists; D000319:Adrenergic beta-Antagonists; D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D018765:Dopamine Uptake Inhibitors; D018340:Receptors, Adrenergic, alpha-1; D004958:Estradiol; D011433:Propranolol; D003042:Cocaine; D009638:Norepinephrine