[p53 mutation does not determine prognosis in non-Hodgkin's lymphoma].
We studied the clinical significance of the extent of p53 protein expression by immunohistochemical analysis and p53 mutations by functional analysis of p53 in 42 patients with high and intermediate grade of Non-Hodgkin's Lymphoma (NHL). Neither p53 expression nor mutation correlated with short survival or resistance to chemoradiotherapy, implying that p53 mutation is not a prognostic factor in NHL.
Osada
M
M
Dept. of Clinical Oncology, Tohoku University.
Ishioka
C
C
Murakawa
Y
Y
Ichinohasama
R
R
Kanamaru
R
R
Ikawa
S
S
D016158:Genes, p53; D006801:Humans; D007150:Immunohistochemistry; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000378:metabolism / Q000401:mortality*; D009154:Mutation; D011379:Prognosis; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
D016159:Tumor Suppressor Protein p53