Wnt signalling goes nuclear.
The Wnt signalling cascade is a highly conserved signalling pathway throughout the animal kingdom. In Xenopus, Wnt signalling functions in mesodermal dorsoventral patterning. Earlier work on deciphering the components of the wnt signalling cascade left a gap between cytosolic beta-catenin, the final member of the cascade, and the nuclear target genes. Several recent papers now reveal how the Wnt signal is transmitted into the nucleus. Surprisingly, beta-catenin directly interacts with the transcription factor LEF-1/XTCF-3, and thereby is not only translocated into the nucleus but also modulates the properties of LEF-1/XTCF-3 as a transcription factor.
Kühl
M
M
Abt. Biochemie, Universität Ulm, Germany.
Wedlich
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D000818:Animals; D002467:Cell Nucleus / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000502:physiology; D004330:Drosophila; D011506:Proteins / Q000502:physiology*; D015398:Signal Transduction; D015534:Trans-Activators; D014157:Transcription Factors / Q000502:physiology; D051153:Wnt Proteins; D000071818:Wnt-5a Protein; D014981:Xenopus; D029867:Xenopus Proteins; D051176:beta Catenin
C495266:CTNNB1 protein, Xenopus; D003598:Cytoskeletal Proteins; D011506:Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D051153:Wnt Proteins; D000071818:Wnt-5a Protein; C085096:Wnt5a protein, Xenopus; D029867:Xenopus Proteins; D051176:beta Catenin