Subsets of activated T cells in patients with systemic lupus erythematosus: the relation to cell cycle.
The correlation among the various markers of activated T cells (soluble interleukin 2 receptor (sIL-2R), HLA-DR+ and HLA-DP+ T cells, proliferating cell nuclear antigen (PCNA) positive lymphocytes) were examined in patients with systemic lupus erythematosus (SLE), and related to the cell cycle. The concentration of sIL-2R and the proportion of HLA-DR+ T cells, HLA-DP+ T cells or PCNA+ lymphocytes were increased significantly as compared to that in normal subjects. And, the concentrations of sIL-2R correlated with the proportions of PCNA+ lymphocytes, but not with the proportions of HLA-DR+ T cells, HLA-DP+ T cells. The correlation between sIL-2R and PCNA+ lymphocytes was attributed to both indicators being increased during the G1B or S phase in normal T cells upon stimulation by phytohemagglutinin (PHA). Upon cell cycle analysis it was learned that activated T cells could be found in the G1A and the S phases.
Tokano
Y
Y
Department of Rheumatology and Internal Medicine, Juntendo University, Tokyo, Japan.
Morimoto
S
S
Hishikawa
T
T
Murashima
A
A
Abe
M
M
Sekigawa
I
I
Takasaki
Y
Y
Hashimoto
H
H
Okumura
K
K
Shirai
T
T
Hirose
S
S
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D002453:Cell Cycle / Q000276:immunology*; D005260:Female; D006682:HLA-DP Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D015375:Receptors, Interleukin-2 / Q000032:analysis; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D015415:Biomarkers; D006682:HLA-DP Antigens; D006684:HLA-DR Antigens; D018809:Proliferating Cell Nuclear Antigen; D015375:Receptors, Interleukin-2