title: Cerebral perfusion correlates of depressed mood.
abstract: BACKGROUND
  The spontaneous diurnal variation of mood and other symptoms provides a substrate for the examination of the relationship between symptoms and regional brain activation in depression.
  
  
  METHODS
  Twenty unipolar depressed patients with diurnal variation of mood were examined at 8 a.m. and 8 p.m. with neuropsychological measures, clinical ratings and single photon emission tomography (SPET). Brain perfusion maps were spatially transformed into standard stereotactic space and compared pixel-by-pixel. A parametric (correlational) analysis was used to examine the relationship between symptom severity and brain perfusion, both between and within subjects.
  
  
  RESULTS
  Global depression severity and an independent 'vital' depression factor were associated in subjects with increased perfusion in cingulate and other paralimbic areas. In addition there was a probable association between an increase in an anxious-depression factor and reduced frontal neocortical perfusion.
  
  
  CONCLUSIONS
  Depressive symptom changes are associated with metabolic changes in the cingulate gyrus and associated paralimbic structures.
authors.affiliation: Medical Research Council Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh.
authors.forename: K P
authors.initials: KP
authors.lastname: Ebmeier
authors.forename: J T
authors.initials: JT
authors.lastname: Cavanagh
authors.forename: A P
authors.initials: AP
authors.lastname: Moffoot
authors.forename: M F
authors.initials: MF
authors.lastname: Glabus
authors.forename: R E
authors.initials: RE
authors.lastname: O'Carroll
authors.forename: G M
authors.initials: GM
authors.lastname: Goodwin
mesh_terms: D000328:Adult; D001007:Anxiety / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002940:Circadian Rhythm; D003866:Depressive Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D014055:Tomography, Emission-Computed
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime