title: [Current diagnosis and prognostic importance of EBV-associated neoplasms].
abstract: In addition to endemic Burkitt's lymphoma and nasopharyngeal carcinoma a variety of other epithelial-and lymphoid-derived proliferative diseases has been shown to closely link with Epstein-Barr virus (EBV) infection. The former include thymic lymphoepithelial carcinoma, oral hairy leukoplakia and gastric carcinoma. The latter include B-cell lymphoproliferative disorders arising in individuals with primary or secondary immunodeficiency, Hodgkin's disease and T/NK lymphoma. The significance of serological, immunohistochemical and molecular biological methods such as PCR, in situ hybridization and Southern blotting is described. And also the possible prognostic impact of EBV in T/NK-lymphoma is discussed.
authors.affiliation: Osaka Medical Center.
authors.forename: K
authors.initials: K
authors.lastname: Kawa
mesh_terms: D006566:Herpesviridae Infections / Q000175:diagnosis* / Q000628:therapy; D004854:Herpesvirus 4, Human; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy; D014412:Tumor Virus Infections / Q000175:diagnosis* / Q000628:therapy