Three cases of contact allergy after chemical burns from methylchloroisothiazolinone/methylisothiazolinone: one with concomitant allergy to methyldibromoglutaronitrile/phenoxyethanol.
BACKGROUND
Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) is known to be a contact sensitizer. It is used extensively in cosmetic products in low concentrations. Occupational exposure usually occurs with concentrated solutions and results in a different reaction pattern.


RESULTS
Three workers developed chemical burns and subsequent sensitization after exposure to concentrated solutions of MCI/MI. One patient was also occupationally sensitized to methyldibromoglutaronitrile/phenoxyethanol.


CONCLUSIONS
Exposure to concentrated solutions of some allergens can be severely irritating in the occupational setting and can probably induce sensitization.
Primka
E J
EJ
Cleveland Clinic Foundation, Department of Dermatology, OH, USA.
Taylor
J S
JS
D000328:Adult; D002057:Burns, Chemical / Q000150:complications* / Q000209:etiology; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000209:etiology*; D004202:Disinfectants / Q000009:adverse effects*; D006801:Humans; D007221:Industry; D008297:Male; D008875:Middle Aged; D009570:Nitriles / Q000009:adverse effects*; D010328:Patch Tests; D013844:Thiazoles / Q000009:adverse effects*
D004202:Disinfectants; D009570:Nitriles; D013844:Thiazoles; C037057:Kathon 886; C039411:1,2-dibromo-2,4-dicyanobutane