Relative activity of N-(beta-D-glucopyranosyl)nicotinic acid to nicotinic acid as a niacin nutrient in rats and in Lactobacillus plantarum ATCC 8014.
We investigated the relative activity of N-(beta-D-glucopyranosyl)-nicotinic acid as a niacin nutrient in rats and in Lactobacillus plantarum ATCC 8014. N-(beta-D-Glucopyranosyl)-nicotinic acid is a detoxified product or storage form of nicotinic acid that is found in plants. The relative activity of N-(beta-D-glucopyranosyl)nicotinic acid to nicotinic acid in rats was 1/2.3, 1/2.2, 1/1.0, and 1/1.7 as indices of the body weight gain, food intake, blood NAD content, and the increased urinary excretion of niacin and its metabolites, respectively. N-(beta-D-Glucopyranosyl)nicotinic acid had no niacin activity in Lactobacillus plantarum ATCC 8014.
Nishitani
H
H
R&D Center, Terumo Corporation, Kanagawa, Japan.
Taguchi
H
H
Yonezima
M
M
Shibata
K
K
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005947:Glucose / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D007778:Lactobacillus / Q000378:metabolism*; D008297:Male; D009243:NAD / Q000097:blood; D009525:Niacin / Q000378:metabolism / Q000494:pharmacology*; D009536:Niacinamide / Q000031:analogs & derivatives / Q000652:urine; D009539:Nicotinic Acids / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
C099086:N-glucopyranosylnicotinic acid; D009539:Nicotinic Acids; D009243:NAD; D009536:Niacinamide; D009525:Niacin; C005211:N'-methyl-2-pyridone-5-carboxamide; D005947:Glucose