Hematopoiesis: origin pinned down at last?
The sequence of events leading to definitive adult hematopoiesis in the mouse has long been debated. The traditional notion that yolk-sac-derived stem cells seed the adult compartment has now been challenged by evidence that intra-embryonic stem cells play a crucial role.
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Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria, 3050, Australia.
D000818:Animals; D004622:Embryo, Mammalian / Q000502:physiology; D006410:Hematopoiesis / Q000502:physiology*; D051379:Mice; D013234:Stem Cells / Q000502:physiology