title: Iridoschisis: high frequency ultrasound imaging. Evidence for a genetic defect?
abstract: OBJECTIVE
  To elucidate changes in the anatomy of the anterior chamber associated with iridoschisis, a rare form of iris atrophy, and their potential contribution to angle closure glaucoma.
  
  
  METHODS
  Both eyes of a 71-year-old woman with bilateral iridoschisis and fibrous dysplasia and her asymptomatic 50-year-old daughter were scanned with a very high frequency (50 MHz) ultrasound system.
  
  
  RESULTS
  The symptomatic patient exhibited diffuse changes in the iris stoma with an intact posterior iris pigmented layer in both eyes. These changes were clinically compatible with the lack of iris transillumination defects. Additionally, iris bowing with a resultant narrowing of the angle occurred. The asymptomatic daughter showed discrete, but less severe iris stromal changes.
  
  
  CONCLUSIONS
  This is the first detailed study of high frequency ultrasonic imaging of the iris in iridoschisis. The observed structural changes suggest angle narrowing by forward bowing of the anterior iris stroma may be a mechanism of IOP elevation in this condition. The ultrasonic detection of iris changes in the asymptomatic daughter of the symptomatic patient and the association of iridoschisis with fibrous dysplasia suggest a possible genetic component in the pathogenesis of this condition.
authors.affiliation: Mt Sinai School of Medicine, New York, USA.
authors.forename: J
authors.initials: J
authors.lastname: Danias
authors.forename: I M
authors.initials: IM
authors.lastname: Aslanides
authors.forename: J W
authors.initials: JW
authors.lastname: Eichenbaum
authors.forename: R H
authors.initials: RH
authors.lastname: Silverman
authors.forename: D Z
authors.initials: DZ
authors.lastname: Reinstein
authors.forename: D J
authors.initials: DJ
authors.lastname: Coleman
mesh_terms: D000368:Aged; D001284:Atrophy; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000209:etiology*; D006801:Humans; D007499:Iris Diseases / Q000000981:diagnostic imaging / Q000235:genetics*; D008850:Microphthalmos / Q000150:complications; D008875:Middle Aged; D010375:Pedigree; D014463:Ultrasonography