Serum cholesterol reduction and cholesterol absorption inhibition in CaCo-2 cells by a soyprotein peptic hydrolyzate.
The serum cholesterol level in rats was significantly decreased in a group fed on a soyprotein peptic hydrolyzate (SPH) when compared with a group fed on a casein tryptic hydrolyzate (CTH). The fecal excretion of total steroids was significantly greater with rats fed on the SPH diet when compared with the CTH diet. The results of CaCo-2 studies clearly suggest that the suppression of cholesterol absorption in the intestinal epithelia is part of the mechanism for the hypocholesterolemic action induced by SPH.
Nagaoka
S
S
Department of Food Science, Faculty of Agriculture, Gifu University, Japan.
Awano
T
T
Nagata
N
N
Masaoka
M
M
Hori
G
G
Hashimoto
K
K
D000818:Animals; D000924:Anticholesteremic Agents / Q000737:chemistry / Q000494:pharmacology*; D018938:Caco-2 Cells; D002784:Cholesterol / Q000378:metabolism*; D006801:Humans; D008297:Male; D011492:Protein Hydrolysates / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D030262:Soybean Proteins / Q000737:chemistry / Q000494:pharmacology*; D013025:Glycine max / Q000378:metabolism
D000924:Anticholesteremic Agents; D011492:Protein Hydrolysates; D030262:Soybean Proteins; D002784:Cholesterol