[Nasopharyngeal carcinoma: present and future].
Nasopharyngeal carcinoma (NPC) is one of important problems of public health in the south of Asian countries and North Africa. The Epstein-Barr virus(EBV) is thought to be a key factor in this cancer as attested by several facts: the constant presence of the EBV genome in all malignant cells, the expression of several viral proteins with known oncogenic activity and the precession of serological modifications. Several proto-oncogenes were also activated in relation with viral gene expression. A possible presence of chromosome deletion in the region where some anti-oncogenes are localized, was also described. From these observations, future objective in NPC research will be to define whether EBV is a sole responsible factor in the development of NPC.
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Laboratorie de Virologie MolécuPaire, I.V.M.C. UMR5537, Faculté de Médecine R.T.H. Laënnec, Université Claude Bernard-Lyon I.
D000914:Antibodies, Viral / Q000032:analysis; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000821:virology*; D014764:Viral Proteins / Q000032:analysis
D000914:Antibodies, Viral; D014764:Viral Proteins