Event-related potentials and performance of attention-deficit hyperactivity disorder: children and normal controls in auditory and visual selective attention tasks.
Attention-deficit hyperactivity disorder (ADHD) children and normal controls (7-13 yrs old) performed an auditory and visual selective attention task. Subjects were instructed to respond to the infrequent (10%) stimuli in the relevant channel. Processing negativity (PN) and several other ERP peaks were scored at the midline electrodes. In the auditory task, controls had more correct detections (hits), less false alarms, larger P3b amplitudes to nontarget stimuli (but not to hits), a larger central PN and larger early frontal positivity (100-250 ms) to target stimuli than ADHD subjects. In the visual modality, controls had more correct detections, less false alarms, larger P3b amplitudes to nontarget stimuli (but not to hits), and larger frontal P3(1) amplitudes to infrequent than to frequent stimuli. It was hypothesized that in ADHD children in both the auditory and the visual task, there is a deficit in the activation of the P3b process. Incorrect triggering of the P3b process might be caused by disturbances in other aspects of the attention process, preceding the P3b.
Jonkman
L M
LM
Faculty of Pharmacy, Department of Psychopharmacology, Rudolph Magnus Institute for Neurosciences, Utrecht University, The Netherlands.
Kemner
C
C
Verbaten
M N
MN
Koelega
H S
HS
Camfferman
G
G
vd Gaag
R J
RJ
Buitelaar
J K
JK
van Engeland
H
H
D000293:Adolescent; D001143:Arousal / Q000502:physiology*; D001288:Attention / Q000502:physiology*; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D001307:Auditory Perception / Q000502:physiology*; D001931:Brain Mapping; D002648:Child; D003265:Contingent Negative Variation / Q000502:physiology; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology; D005074:Evoked Potentials, Visual / Q000502:physiology; D005260:Female; D005583:Fourier Analysis; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008297:Male; D012016:Reference Values; D012815:Signal Processing, Computer-Assisted; D014796:Visual Perception / Q000502:physiology*