Preventive effect of lithospermate B from Salvia miltiorhiza on experimental hepatitis induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide.
The water extract from the root of Salvia miltiorhiza Bunge showed a protective effect on cultured rat hepatocytes against carbon tetrachloride (CCl4)-induced necrosis. A further study was carried out to isolate the active constituent. Activity guided fractionation of the extract and chemical analysis gave us lithospermate B (a salt of lithospermic acid B), a tetramer of caffeic acid. Lithospermate B was also found to have a potent hepatoprotective activity in not only in vitro but also in vivo experimental liver injuries induced by CCl4 or D-galactosamine (D-GalN)/lipopolysaccharide (LPS).
Hase
K
K
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Japan.
Kasimu
R
R
Basnet
P
P
Kadota
S
S
Namba
T
T
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000627:therapeutic use*; D005688:Galactosamine / Q000633:toxicity*; D066298:In Vitro Techniques; D008070:Lipopolysaccharides / Q000633:toxicity*; D008297:Male; D008516:Medicine, Chinese Traditional; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; C061091:lithospermate B; D005688:Galactosamine; D002251:Carbon Tetrachloride