Effects of SWL on glomerular filtration rate and renal plasma flow in uninephrectomized minipigs.
This study tested the hypothesis that the effects of SWL on hemodynamics in solitary kidneys differ from those in kidneys of binephric animals. Five female miniature pigs (Pitman-Moore, 6 months of age, 30-35 kg) were anesthetized for unilateral nephrectomy. Seven pigs served as binephric controls. Two weeks later, each pig was anesthetized, prepared for unilateral or bilateral urine collections, and subjected to SWL (Dornier HM3, 2000 shocks, 24 kV). Clearances of inulin (glomerular filtration rate; GFR) and para-aminohippurate (renal plasma flow; RPF) were measured 1 hour prior to and 1, 4, and 24 hours after SWL. The GFR and RPF were higher in uninephrectomized than in intact pigs at all time points. In both groups, SWL reduced GFR and RPF. In the binephric pigs, RPF was reduced at all times post-SWL, but in the uninephrectomized pigs, RPF was returning toward baseline by 4 hours post-SWL and was not different from baseline at 24 hours. A comparison of whole-animal GFR and RPF (righ plus left clearances in binephric pigs v solitary renal clearances in uninephrectomized pigs) showed that whole-animal GFR and RPF did not differ between the groups before or after SWL. Compensatory renal hypertrophy and improved hemodynamics in solitary kidneys may acutely attenuate the renal vasoconstrictive effect of SWL. The long-term consequences of the compensatory changes are unknown.
Willis
L R
LR
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, USA.
Evan
A P
AP
Connors
B A
BA
Fineberg
N S
NS
Lingeman
J E
JE
D000818:Animals; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006417:Hematuria / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D006984:Hypertrophy; D007444:Inulin; D007668:Kidney / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D008096:Lithotripsy; D009392:Nephrectomy; D017595:Renal Plasma Flow / Q000502:physiology*; D013552:Swine; D013556:Swine, Miniature; D014563:Urodynamics; D010130:p-Aminohippuric Acid
D007444:Inulin; D010130:p-Aminohippuric Acid