title: Ginseng total saponin inhibits the dopaminergic depletions induced by methamphetamine.
abstract: Pretreatment with ginseng total saponin (GTS) reduced the magnitude of the methamphetamine-induced dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillinic acid (HVA) depletions. It is suggested that GTS can, in part, prevent the methamphetamine-induced striatal dopaminergic depletions.
authors.affiliation: Department of Pharmacology, College of Pharmacy, Chungbuk National University, Cheongju, Korea.
authors.forename: K W
authors.initials: KW
authors.lastname: Oh
authors.forename: H S
authors.initials: HS
authors.lastname: Kim
authors.forename: G C
authors.initials: GC
authors.lastname: Wagner
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003342:Corpus Striatum / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D018765:Dopamine Uptake Inhibitors / Q000037:antagonists & inhibitors*; D004563:Electrochemistry; D006719:Homovanillic Acid / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008297:Male; D008694:Methamphetamine / Q000037:antagonists & inhibitors*; D051379:Mice; D005894:Panax / Q000737:chemistry*; D010946:Plants, Medicinal; D012503:Saponins / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D018765:Dopamine Uptake Inhibitors; D012503:Saponins; D015102:3,4-Dihydroxyphenylacetic Acid; D008694:Methamphetamine; D004298:Dopamine; D006719:Homovanillic Acid