TAP polymorphisms in Swedish myasthenia gravis patients.
The association between myasthenia gravis (MG) and TAP polymorphisms was studied in 79 Swedish patients and 155 unrelated controls. TAP typing was performed by ARMS-PCR technique and stratification analysis was used to determine if the TAP associations were independent or secondary to linkage disequilibrium with DQ2 and DR3. TAP1 and TAP2 alleles did not confer independent risk for MG. TAP2*0101 was, however, positively associated with MG in patients with an early onset of disease compared to patients with a late onset of disease. TAP1 and TAP2 alleles did not confer risk in MG patients negative for DQ2. In conclusion, susceptibility to MG is not primarily conferred by TAP alleles in the extended DR3 haplotype.
Hjelmström
P
P
Department of Medicine, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden.
Giscombe
R
R
Lefvert
A K
AK
Pirskanen
R
R
Kockum
I
I
Landin-Olsson
M
M
Sanjeevi
C B
CB
D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000483:Alleles; D004198:Disease Susceptibility; D005787:Gene Frequency; D006683:HLA-DQ Antigens / Q000097:blood*; D015803:HLA-DR3 Antigen / Q000097:blood*; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D009157:Myasthenia Gravis / Q000235:genetics* / Q000276:immunology*; D013548:Sweden
D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D006683:HLA-DQ Antigens; C053186:HLA-DQ2 antigen; D015803:HLA-DR3 Antigen; C073119:TAP1 protein, human; C071692:TAP2 protein, human