Reversible palmitoylation of signaling proteins.
Palmitoylation is unique among lipid modifications of proteins in that it is reversible and regulable. Recent advances in the study of palmitoylation include the following: the correlation of this modification with the localization of a signaling protein to specific membrane subdomains; the demonstration of a specific protein-protein interaction that is promoted by palmitoylation; and the identification, characterization, and purification of enzymes catalyzing this modification.
Mumby
S M
SM
Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75235-9041, USA. smumby@mednet.swmed.edu
D002462:Cell Membrane / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism; D019308:Palmitic Acid / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction
D011956:Receptors, Cell Surface; D019308:Palmitic Acid; D019204:GTP-Binding Proteins