Assessment of sperm motion characteristics in infertile renal transplant recipients using computerized analysis.
A total of 34 kidney transplant recipients (18 infertile and 16 fertile) and 31 nontransplant persons (15 infertile and 16 fertile) were included in this study. All subjects were assessed clinically and by measurement of basal concentrations of total testosterone, FSH, cyclosporine whole blood trough levels, serum creatinine, haemoglobin and semen analysis using computer-aided sperm analysis (CASA) as well as scrotal ultrasonography to evaluate testicular dimensions. Our results demonstrate a significant decrease (p < 0.05) in sperm concentration, the percentage of motile spermatozoa, straight line velocity (VSL), linearity (LIN) and velocity of average path (VAP) among infertile transplant patients in comparison with the fertile transplant group. Serum testosterone, FSH levels and testicular dimensions did not differ significantly (p > 0.05) between fertile and infertile transplant recipients. Both sperm concentration and VSL were inversely correlated to the cyclosporine whole blood trough levels (p < 0.05). The time spent on haemodialysis was inversely correlated (p < 0.05) with the percentage of motile spermatozoa and the amplitude of lateral head displacement (ALH). In conclusion, CASA is valuable in evaluation of sperm motility in infertile renal transplant patients. Stabilization of the cyclosporine whole blood trough level within the target therapeutic level and correction of anaemia (if any) could improve the fertility potential in kidney transplant recipients.
Eid
M M
MM
Department of Andrology and Urology, Mansoura University, Egypt.
Abdel-Hamid
I A
IA
Sobh
M A
MA
el-Saied
M A
MA
D000328:Adult; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007248:Infertility, Male / Q000503:physiopathology*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012735:Sexual Dysfunction, Physiological / Q000503:physiopathology; D013081:Sperm Motility; D013737:Testis / Q000473:pathology
D007166:Immunosuppressive Agents