Pulmonary sarcoid-like granulomata in a patient treated for extrapulmonary Hodgkin's disease.
We report a case of interstitial lung disease developing during treatment with chlorambucil, vinblastine, procarbazine and prednisone for extrapulmonary Hodgkin's disease. Transbronchial biopsies demonstrated noncaseating epithelioid cell granulomata, and bronchoalveolar lavage fluid showed an increased percentage of lymphocytes, with a raised T cell helper-suppressor ratio, suggesting a diagnosis of sarcoidosis. Treatment with corticosteroids brought about complete resolution of the radiographic lesions. A possible relationship between sarcoidosis and lymphoma is discussed, and a short review of the literature is given. This case report has some unique features that, to our knowledge, have not been published before.
van den Berg
Department of Respiratory Diseases, De Wever Hospital, Heerlen, The Netherlands.
Fickers
M
M
Theunissen
P
P
van Noord
J A
JA
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D006689:Hodgkin Disease / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D012074:Remission Induction; D017565:Sarcoidosis, Pulmonary / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014057:Tomography, X-Ray Computed
D000893:Anti-Inflammatory Agents; D011241:Prednisone