title: Inhibition of IL-1-induced IL-6 production by synthetic retinoids.
abstract: The effects of retinoids and retinoid antagonists on IL-6 production in MC3T3-E1 cells were investigated. None of the synthetic retinoids examined stimulated IL-6 production, but all of them strongly inhibited IL-6 production induced by mouse IL-1 alpha. Their inhibitory activities correlated well with their differentiation-inducing activities in HL-60 assay or their binding affinities to nuclear retinoic acid receptors (RARs). Among three retinoid antagonists, two weak antagonists exhibited similar inhibition of mouse IL-1 alpha-induced IL-6 production, whereas a potent retinoid antagonist, 4-(13H-10,11,12,13-tetrahydro-10,10,13,13,15-pentamethyl-dinaph tho[2,3-b] [1,2-e]diazepin-7-yl)benzoic acid (LE540, 14), enhanced IL-6 production under the same conditions.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kagechika
authors.forename: E
authors.initials: E
authors.lastname: Kawachi
authors.forename: H
authors.initials: H
authors.lastname: Fukasawa
authors.forename: G
authors.initials: G
authors.lastname: Saito
authors.forename: N
authors.initials: N
authors.lastname: Iwanami
authors.forename: H
authors.initials: H
authors.lastname: Umemiya
authors.forename: Y
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: K
authors.initials: K
authors.lastname: Shudo
mesh_terms: D016475:3T3 Cells; D000818:Animals; D003984:Dibenzazepines / Q000494:pharmacology; D007375:Interleukin-1 / Q000494:pharmacology*; D015850:Interleukin-6 / Q000096:biosynthesis*; D051379:Mice; D018168:Receptors, Retinoic Acid / Q000187:drug effects; D012176:Retinoids / Q000037:antagonists & inhibitors / Q000494:pharmacology*
chemical_list: D003984:Dibenzazepines; D007375:Interleukin-1; D015850:Interleukin-6; C104182:LE 135; C104183:LE 540; D018168:Receptors, Retinoic Acid; D012176:Retinoids