Novel transferable beta-lactam resistance with cephalosporinase characteristics in Salmonella enteritidis.
An isolate of Salmonella enteritidis was found to produce a plasmid-encoded beta-lactamase (DHA-1) that conferred resistance to extended-spectrum cephalosporins and cephamycins. The substrate and inhibition profiles of this enzyme resemble a class C beta-lactamase. This is the first report of a plasmid-mediated cephalosporinase of this class in the Salmonella genus.
Gaillot
O
O
Department of Microbiology, King Fahd Military Medical Complex, Dhahran, Kingdom of Saudi Arabia.
Clément
C
C
Simonet
M
M
Philippon
A
A
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002510:Cephalosporinase / Q000378:metabolism*; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000494:pharmacology; D003227:Conjugation, Genetic; D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D018014:Gene Transfer Techniques; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010957:Plasmids; D012477:Salmonella enteritidis / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D018440:beta-Lactam Resistance / Q000235:genetics*; D065093:beta-Lactamase Inhibitors
D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D004269:DNA, Bacterial; D004791:Enzyme Inhibitors; D065093:beta-Lactamase Inhibitors; D019818:Clavulanic Acid; D002510:Cephalosporinase