title: Malignant fibrous histiocytoma secondary to fibrous dysplasia. A case report.
abstract: A man of 50 years of age had a malignant fibrous histiocytoma secondary to asymptomatic fibrous dysplasia of the proximal femur. Radiographs showed ill-defined osteolytic changes near to the fibrous lesion which had a ground glass appearance. The histology was of a malignant fibrous histiocytoma concomitant with fibrous dysplasia. An extensive resection of the tumour was carried out and chemotherapy given, but the patient died from a liver metastasis 9 months later. The possibility of malignancy should be considered if a patient with fibrous dysplasia has any progressive symptoms.
authors.affiliation: Department of Orthopaedic Surgery, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ohmori
authors.forename: H
authors.initials: H
authors.lastname: Matsui
authors.forename: M
authors.initials: M
authors.lastname: Kanamori
authors.forename: K
authors.initials: K
authors.lastname: Yudoh
authors.forename: T
authors.initials: T
authors.lastname: Yasuda
authors.forename: S
authors.initials: S
authors.lastname: Terahata
mesh_terms: D002471:Cell Transformation, Neoplastic; D017809:Fatal Outcome; D005266:Femoral Neoplasms / Q000473:pathology* / Q000601:surgery; D005269:Femur / Q000473:pathology* / Q000601:surgery; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged