title: Validation of chromatographic methods in biomedical analysis. Viewpoint and discussion.
abstract: Bioanalytical method validation is the process used to establish that a quantitative analytical method is suitable for biomedical applications. Reassurances as to the quality of the method and its reliability come from adopting a minimum series of validation experiments and obtaining satisfactory results. Consistent evaluation of the key analytical parameters: recovery, response function, sensitivity, precision, accuracy, selectivity and stability, is discussed with a view to improving scientific standards in manuscripts submitted for publication.
authors.affiliation: GlaxoWellcome Research and Development, Beckenham, Kent, UK.
authors.forename: R
authors.initials: R
authors.lastname: Causon
mesh_terms: D002845:Chromatography / Q000379:methods*; D006801:Humans; D011786:Quality Control; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity