title: Drug efflux as a mechanism of resistance.
abstract: A review of efflux as a mechanism of antibiotic resistance in both bacterial and eukaryotic cells is presented. This covers membrane transport, the evolution of efflux transporters, their genetic control and classification into families, and an appreciation of the widespread distribution and occurrence of these mechanisms in nature.
authors.affiliation: Department of Biology, Birkbeck College, University of London, England, UK.
authors.forename: J B
authors.initials: JB
authors.lastname: Williams
mesh_terms: D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D001419:Bacteria / Q000187:drug effects / Q000378:metabolism; D001693:Biological Transport, Active / Q000235:genetics; D004352:Drug Resistance, Microbial / Q000235:genetics / Q000502:physiology*; D005057:Eukaryotic Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents