Prognostic value from DNA quantification by static cytometry in breast cancer.
OBJECTIVE
To determine if DNA quantification on fine needle aspiration (FNA) has predictive value in breast cancer.


METHODS
Forty-nine patients with breast cancer were selected for this study because of their common characteristics. The smears were studied using image cytometry.


RESULTS
With the type of histogram and value of entropy, two large groups, with high and low degrees of malignancy, were obtained. Survival was utilized as a variable of interest. Kaplan-Meier survival curves for both groups were formulated, and the results were supported with statistical data.


CONCLUSIONS
The survival differences between both groups were statistically significant (P < .001), thus demonstrating the predictive value of DNA quantification.
Azúa
J
J
Department of Morphologic Sciences, Faculty of Medicine, University of Zaragoza, Spain.
Romeo
P
P
Serrano
M
M
Martinez Tello
D
D
Azúa
J
J
D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology*; D004396:Coloring Agents; D004273:DNA, Neoplasm / Q000032:analysis*; D018450:Disease Progression; D005260:Female; D006416:Hematoxylin; D006801:Humans; D019044:Image Cytometry / Q000379:methods*; D011003:Ploidies; D011237:Predictive Value of Tests; D012984:Software; D015996:Survival Rate
D004396:Coloring Agents; D004273:DNA, Neoplasm; D006416:Hematoxylin