How receptors talk to trimeric G proteins.
Stimulated by hormones and sensory stimuli, serpentine receptors promote the release of GDP that is bound to the alpha subunit of trimeric G proteins and its replacement by GTP. Recent investigations have begun to define the sizes, shapes, and relative orientations of receptors and G proteins, the surfaces through which they interact with one another, and conformational changes in both sets of molecules that underlie receptor-catalyzed guanine-nucleotide exchange.
Bourne
H R
HR
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA. hbourne@quickmail.ucsf.edu
D000818:Animals; D019204:GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D006153:Guanosine Diphosphate / Q000378:metabolism; D006801:Humans; D008968:Molecular Conformation; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism*
D011956:Receptors, Cell Surface; D006153:Guanosine Diphosphate; D019204:GTP-Binding Proteins