Physiological regulation of blood pressure and kidney function by guanylyl cyclase isoforms.
Guanylyl cyclase isoforms can serve as receptors for various molecules including atrial natriuretic peptide, brain natriuretic peptide, C-type natriuretic peptide and nitric oxide. It has been speculated these signaling pathways are important regulators of cardiovascular and renal physiology. Within the past year, gene targeting in particular has strengthened this speculation, suggesting critical roles of guanylyl cyclase receptors in both the chronic and acute regulation of blood pressure.
Kishimoto
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Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas 75235-9050, USA.
Garbers
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D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D006162:Guanylate Cyclase / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007527:Isoenzymes / Q000502:physiology*; D007668:Kidney / Q000201:enzymology* / Q000502:physiology*
D007527:Isoenzymes; D006162:Guanylate Cyclase