Effects of dopamine agonists on Cebus apella monkeys with previous long-term exposure to fluphenazine.
Sixty-one weeks after 48 weeks of treatment with fluphenazine decanoate or placebo, 37 socially living Cebus apella monkeys were evaluated for differences in dopaminergic sensitivity by exposure to 0.75 mg/kg, i.m. of amphetamine (AMPH) (indirect agonist) and apomorphine (APOM) (direct agonist). The fluphenazine-treated animals differed (p < or = 0.05) from control animals on some hourly measures of composite behavioral variables (CBVs). Animals exposed to fluphenazine showed a greater decrease in the aggressiveness CBV and a smaller decrease in self- and environment-directed behaviors than placebo animals. CBVs for normal locomotion and directs affiliation showed no significant differences. The fluphenazine-treated group showed greater agonist induction of stereotypic behavior (p < or = 0.01), and larger decreases in prolactin response to AMPH (p < or = 0.05). Our findings indicate that following extended treatment with an antipsychotic there is increased sensitivity to dopamine, as evidenced by stereotypies and possibly hypophyseal responsiveness.
Lifshitz
K
K
Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA.
O'Keeffe
R T
RT
Linn
G S
GS
Lee
K L
KL
Camp-Bruno
J A
JA
Suckow
R F
RF
D000661:Amphetamine / Q000097:blood / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000097:blood / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D002428:Cebus; D018491:Dopamine Agonists / Q000097:blood / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000097:blood / Q000494:pharmacology*; D005260:Female; D005476:Fluphenazine / Q000097:blood / Q000494:pharmacology*; D013006:Growth Hormone / Q000097:blood; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011388:Prolactin / Q000097:blood; D013239:Stereotyped Behavior / Q000187:drug effects
D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D011388:Prolactin; D013006:Growth Hormone; D000661:Amphetamine; D001058:Apomorphine; D005476:Fluphenazine