title: Differentiating full thickness macular holes from impending macular holes and macular pseudoholes.
abstract: OBJECTIVE
  The reliability of scanning laser ophthalmoscope (SLO) microperimetry in differentiating full thickness macular holes from macular pseudoholes and impending macular holes was evaluated.
  
  
  METHODS
  106 eyes with the clinical diagnosis of full thickness macular holes, macular pseudoholes, and impending (stage 1) macular holes were examined for the presence of deep or relative scotoma using SLO microperimetry. The relation between these scotomas and the clinical diagnosis was studied.
  
  
  RESULTS
  Deep and relative scotomas were detected in all 57 eyes with clinically defined full thickness macular holes. In contrast, among 49 eyes diagnosed with macular pseudoholes or impending macular holes, no deep and only one relative scotoma was observed. The sensitivity of the presence of a deep scotoma as an indicator of the clinical diagnosis of a full thickness macular hole was 100% (57 of 57), and the specificity was 100% (49 of 49). The sensitivity of the presence of a relative scotoma was 100% (57 of 57) and the specificity was 98.0% (48 of 49).
  
  
  CONCLUSIONS
  With SLO microperimetry, full thickness macular holes can be precisely and objectively distinguished from other conditions that mimic macular holes.
authors.affiliation: Department of Ophthalmology, Osaka University Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tsujikawa
authors.forename: M
authors.initials: M
authors.lastname: Ohji
authors.forename: T
authors.initials: T
authors.lastname: Fujikado
authors.forename: Y
authors.initials: Y
authors.lastname: Saito
authors.forename: M
authors.initials: M
authors.lastname: Motokura
authors.forename: I
authors.initials: I
authors.lastname: Ishimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Tano
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D007834:Lasers; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D012164:Retinal Diseases / Q000175:diagnosis; D012167:Retinal Perforations / Q000150:complications / Q000175:diagnosis*; D012607:Scotoma / Q000175:diagnosis / Q000209:etiology*; D012680:Sensitivity and Specificity; D058609:Visual Field Tests / Q000379:methods