An indoor air quality-pharmacokinetic simulation of passive inhalation of marijuana smoke and the resultant buildup of 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid in urine.
In military courts of law, the good soldier defense is often used by the defendant to explain the presence of 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid in urine (hereafter referred to as THCA) above the Department of Defense (DOD) established limit of 15 ng/mL. The defense will contend the defendant unwittingly breathed side-stream marijuana smoke, thus resulting in the presence of THCA in the defendant's urine. The purpose of this work was to link an indoor air quality model (IAQ) with a pharmacokinetic (PK) model to predict a passive marijuana smoker's resultant concentration of the major urinary metabolite THCA.
Giardino
N J
NJ
Armstrong Laboratory, Occupational Environmental Medicine and Health, Brooks Air Force Base, San Antonio, TX 78235-5114, USA.
D000393:Air Pollutants / Q000493:pharmacokinetics* / Q000652:urine*; D016902:Air Pollution, Indoor / Q000032:analysis*; D002188:Cannabis / Q000378:metabolism*; D003198:Computer Simulation; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000652:urine; D006801:Humans; D008962:Models, Theoretical; D014028:Tobacco Smoke Pollution / Q000331:legislation & jurisprudence*
D000393:Air Pollutants; D014028:Tobacco Smoke Pollution; C016780:11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid; D013759:Dronabinol