[The effect of calcium chloride on the distribution, protein binding and catabolism of 14C-biotin in the body of white mice].
Calcium chloride injected intramuscularly to white mice in the therapeutical dose of 50 mM/kg, influences considerably distribution, proteidization, enterohepatic recycling level, elimination from the blood, excretion with urine and catabolism of 14C-biotin injected simultaneously in the physiological dose of 0.5 mM/kg. CaCl2 decreases and retards inflow of the 14C-biotin general radio-label to the analyzed tissues and organs, with the simultaneous increase of its proteidization in the same tissues. At the same time permeability of histohematic barriers of these tissues for 14C-biotin under the CaCl2 effect falls markedly. Calcium chloride increases the level of complete catabolism of 14C-biotin to 14CO2 by 51% 480 min after their simultaneous injection. A conclusion is made that calcium introduced as CaCl2 in the mentioned dose inhibits enterohepatic recycling of 14C-biotin in the white mice organism with the simultaneous of 14C-biotin assimilation in the analyzed tissues.
El'kina
V A
VA
Rozanov
A Ia
AIa
D000818:Animals; D001710:Biotin / Q000493:pharmacokinetics*; D002122:Calcium Chloride / Q000494:pharmacology*; D002250:Carbon Radioisotopes; D004347:Drug Interactions; D008297:Male; D051379:Mice; D011485:Protein Binding / Q000187:drug effects; D013997:Time Factors; D014018:Tissue Distribution / Q000187:drug effects
D002250:Carbon Radioisotopes; D001710:Biotin; D002122:Calcium Chloride
Vplyv khlorydu kal'tsiiu na rozpodil, proteïdyzatsiiu ta katabolizm 14C-biotynu v orhanizmi bilykh mysheĭ.