Iris juvenile xanthogranuloma studied by immunohistochemistry and flow cytometry.
An unusual large tan iris mass in a 19-month-old child was removed by iridocyclectomy and studied by light microscopy, immunohistochemistry, and flow cytometry. The excised mass consisted of granulomatous inflammation with numerous osteoclast-like giant cells and scattered atypical Touton giant cells. Immunohistochemistry studies showed that the cells were most consistent with mononuclear histiocytes. Flow cytometry showed that 90% of the cells sampled were T-lymphocytes, with a predominance of T-suppresser cytotoxic cells. Juvenile xanthogranuloma (XG) of the iris can occur as a large solitary mass, without signs of intraocular inflammation or hyphema.
Shields
J A
JA
Oncology Service, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Eagle
R C
RC
Shields
C L
CL
Collins
M L
ML
DePotter
P
P
D015415:Biomarkers / Q000032:analysis; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007498:Iris / Q000737:chemistry / Q000473:pathology; D007499:Iris Diseases / Q000473:pathology* / Q000601:surgery; D013601:T-Lymphocytes / Q000473:pathology; D014972:Xanthogranuloma, Juvenile / Q000473:pathology* / Q000601:surgery
D015415:Biomarkers