The antioxidant properties of thioctic acid: characterization by cyclic voltammetry.
Thioctic acid (TA) level and its antioxidant capacity were monitored by cyclic voltammetry (CV), in solution and in human plasma. A linear correlation between the anodic wave current Ia at 900 mV and [TA] was obtained. This indicates that TA, commonly found in human plasma, is an antioxidant component characterized by a potential E1/2 = 900 mV and constitute, at least in part, the second anodic wave of the CV tracing. When plasma from diabetic patients was analyzed by CV, those patients under treatment with TA showed higher Ia than others not taking the drug. When the patients under treatment with TA were divided into groups according to the severity of their nephropathy, or according to the severity of their total complication count, Ia levels representing TA were significantly higher in those patients with more severe complications.
Chevion
S
S
Department of Internal Medicine, Heidelberg University, Germany.
Hofmann
M
M
Ziegler
R
R
Chevion
M
M
Nawroth
P P
PP
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000097:blood* / Q000188:drug therapy; D004563:Electrochemistry; D005260:Female; D006493:Heparin; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D008063:Thioctic Acid / Q000097:blood* / Q000378:metabolism / Q000627:therapeutic use
D000975:Antioxidants; D008063:Thioctic Acid; D006493:Heparin