Illudinic acid, a novel illudane sesquiterpene antibiotic.
A novel illudane sesquiterpene antibiotic (1) with activity against methicillin-resistant Staphylococcus aureus (MRSA), has been isolated. Its MIC against MRSA was found to be 16 micrograms/mL. It also shows L-1210 cytotoxicity with an IC50 of 10-15 micrograms/mL.
Dufresne
C
C
Merck Research Laboratories, Rahway, New Jersey 07065, USA. claude_dufresne@merck.com
Young
K
K
Pelaez
F
F
Gonzalez del Val
A
A
Valentino
D
D
Graham
A
A
Platas
G
G
Bernard
A
A
Zink
D
D
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007939:Leukemia L1210 / Q000473:pathology; D051379:Mice; D008826:Microbial Sensitivity Tests; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D012717:Sesquiterpenes; C104806:illudinic acid