Detection and characterization of human papillomavirus type 45 DNA in the cervical carcinoma cell line MS751.
The cervical carcinoma-derived cell line MS751 was examined for human papillomavirus (HPV) DNA and RNA. A genomic fragment containing both viral and cellular sequences was cloned. Sequence analysis showed that MS751 cells contain a partially deleted HPV-45 genome integrated at a single chromosomal site. HPV sequences from the E6-E7 region are expressed as poly(A)+ RNA.
Geisbill
J
J
Angewandte Tumorvirologie, Deutches Krebsforschungszentrum, Heidelberg, Germany.
Osmers
U
U
Dürst
M
M
D001483:Base Sequence; D004279:DNA, Viral / Q000032:analysis*; D006801:Humans; D008969:Molecular Sequence Data; D027383:Papillomaviridae / Q000235:genetics*; D014407:Tumor Cells, Cultured; D016662:Virus Integration
D004279:DNA, Viral