title: The use of 99Tcm-DTPA aerosol and caesium iodide mini-scintillation detectors in the assessment of lung injury during cardiopulmonary bypass surgery.
abstract: Lung injury is a well-documented adverse effect of cardiopulmonary bypass. The mechanism of injury is not fully understood, but pulmonary hypoxia may be a factor. Post-operative pulmonary epithelial permeability (PEP) in ventilated versus non-ventilated lungs was measured within 2 h of return to the intensive care unit using a 99Tcm-diethylenetriamine pentaacetate aerosol technique. A portable scintillation detector system was required. Sodium iodide detectors have been used previously with this technique but are cumbersome. This study used mini caesium iodide detectors (Oakfield Instruments, Oxon, UK), which can be attached directly to the patient and are more suited to the intensive care setting. The clearance half-time from lung to blood (T1/2LB) was measured in 31 patients (62 lungs). The mean (+/- S.E.M.) clearance half-times were 42.3 +/- 2.7 and 45.7 +/- 3.8 min for non-ventilated and ventilated lungs respectively, with a mean difference of 3.4 +/- 3.1 min (P > 0.05). We conclude that, using this technique, no significant difference in PEP is observed between ventilated and non-ventilated lungs in patients undergoing cardiopulmonary bypass.
authors.affiliation: Regional Medical Physics Department, Freeman Hospital, Newcastle upon Tyne, UK.
authors.forename: P M
authors.initials: PM
authors.lastname: Keavey
authors.forename: A
authors.initials: A
authors.lastname: Hasan
authors.forename: J
authors.initials: J
authors.lastname: Au
authors.forename: J H
authors.initials: JH
authors.lastname: Dark
mesh_terms: D000328:Adult; D000336:Aerosols; D000368:Aged; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D002586:Cesium; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D007454:Iodides; D008168:Lung / Q000000981:diagnostic imaging*; D055370:Lung Injury; D008297:Male; D008875:Middle Aged; D008904:Miniaturization; D011877:Radionuclide Imaging; D012588:Scintillation Counting / Q000295:instrumentation / Q000379:methods; D016284:Technetium Tc 99m Pentetate / Q000008:administration & dosage
chemical_list: D000336:Aerosols; D007454:Iodides; D002586:Cesium; C040050:cesium iodide; D016284:Technetium Tc 99m Pentetate