title: Sucrose polyester does not inhibit gastric acid secretion or stimulate cholecystokinin release in men.
abstract: Replacement of dietary fat by sucrose polyester reduces fat intake. However, little is known about the effects of sucrose polyester on gastrointestinal function. To investigate the effect on gastric acid secretion and on release of cholecystokinin into plasma, we perfused eight healthy male volunteers intraduodenally with sucrose polyester, digestible fat, or saline on separate days in random order. Intraduodenal perfusion of sucrose polyester did not suppress gastrin-stimulated gastric acid secretion (-1.8 +/- 6.8%) whereas digestible fat suppressed gastric acid secretion by 64 +/- 9% (P = 0.001) compared with saline. Sucrose polyester did not affect plasma cholecystokinin concentrations (-12.8 +/- 9.3 pmol.30 min/L) whereas perfusion with digestible fat resulted in a significant increase (31.7 +/- 9.3 pmol.30 min/L, P = 0.017) compared with saline. We conclude that sucrose polyester, in contrast with digestible fat, does not inhibit gastrin-stimulated gastric acid secretion or stimulate release of cholecystokinin.
authors.affiliation: Department of Gastroenterology and Hepatology, University Hospital Nijmegen, Netherlands.
authors.forename: M I
authors.initials: MI
authors.lastname: Maas
authors.forename: W P
authors.initials: WP
authors.lastname: Hopman
authors.forename: T
authors.initials: T
authors.lastname: van der Wijk
authors.forename: M B
authors.initials: MB
authors.lastname: Katan
authors.forename: J B
authors.initials: JB
authors.lastname: Jansen
mesh_terms: D000328:Adult; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D002766:Cholecystokinin / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology; D005227:Fatty Acids / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D005755:Gastrins / Q000097:blood; D006801:Humans; D008297:Male; D011897:Random Allocation; D013270:Stomach / Q000187:drug effects; D013395:Sucrose / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000924:Anticholesteremic Agents; D004041:Dietary Fats; D005227:Fatty Acids; D005755:Gastrins; D013395:Sucrose; C013692:sucrose polyester; D002766:Cholecystokinin