title: BSE: a decade on--Part I.
abstract: Bovine spongiform encephalopathy (BSE), popularly known as "mad cow disease", was discovered in 1986 and has accounted for the deaths of over 165,000 cattle in the UK (by the end of January, 1997) with about 34,000 (mainly dairy) herds involved. The syndrome in the cow includes changes in posture and temperament, apprehension, and loss of coordination. There are many parallels with scraple in sheep, with similar neuropathological changes in the hindbrain that give it a spongiform appearance under the microscope. The facts have been broadly reviewed in The Lancet in 1990 and 1993, and in much more detail elsewhere. In a two-part article, the first of which appears here, we now summarise recent developments.
authors.affiliation: Department of Medical Microbiology, University Medical School, Edinburgh, UK.
authors.forename: J G
authors.initials: JG
authors.lastname: Collee
authors.forename: R
authors.initials: R
authors.lastname: Bradley
mesh_terms: D000821:Animal Feed / Q000009:adverse effects; D000818:Animals; D002417:Cattle; D003612:Dairying; D004196:Disease Outbreaks; D016643:Encephalopathy, Bovine Spongiform / Q000635:transmission; D005506:Food Contamination; D006801:Humans; D011328:Prions; D012608:Scrapie / Q000635:transmission; D012756:Sheep; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D011328:Prions