Evolving growth hormone deficiency in children with a subnormal secretion of growth hormone.
Three growth-retarded children with a normal growth hormone (GH) response to provocative tests, but subnormal 24-hour integrated concentrations of GH and insulin-like growth factor-binding protein 3 (IGF-BP3) are presented. Retesting 3 to 4 years later demonstrated a subnormal GH response to stimulation. The initial subnormal growth rate and IGF-BP3, despite a normal GH response to stimulation, may be secondary to a subnormal integrated concentration of GH.
Zadik
Z
Z
Pediatric Department B, Kaplan Hospital, Rehovot, Israel.
Zung
A
A
Sarel
R
R
Cooper
M
M
D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000175:diagnosis / Q000378:metabolism*; D019382:Human Growth Hormone / Q000172:deficiency* / Q000378:metabolism; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D008297:Male; D011863:Radioimmunoassay; D013997:Time Factors
D018972:Insulin-Like Growth Factor Binding Protein 3; D019382:Human Growth Hormone