title: Electric current density imaging of mice tumors.
abstract: The use of electric current density imaging (CDI) to map spatial distribution of electric currents through tumors is presented. Specifically, a method previously tested on phantoms was implemented in vivo and in vitro for mapping electric current pulses of the same order of magnitude (j approximately 2500 A/m2) as in electrochemotherapy through T50/80 mammary carcinomas, B-16 melanomas and SA-1 sarcomas. A technically simplified method of electric current density imaging is discussed as well. Three geometries of electrodes (flat-flat, point-point, point-flat) indicate altered electric current distribution for the same tumor. This indicates that the method can be used for monitoring the effects of electrochemotherapy as a function of electrode geometry.
authors.affiliation: Jozef Stefan Institute, University of Ljubijana, Slovenia.
authors.forename: I
authors.initials: I
authors.lastname: Sersa
authors.forename: K
authors.initials: K
authors.lastname: Beravs
authors.forename: N J
authors.initials: NJ
authors.lastname: Dodd
authors.forename: S
authors.initials: S
authors.lastname: Zhao
authors.forename: D
authors.initials: D
authors.lastname: Miklavcic
authors.forename: F
authors.initials: F
authors.lastname: Demsar
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D004558:Electric Stimulation; D004566:Electrodes; D005260:Female; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008819:Mice, Nude; D012878:Skin Neoplasms / Q000737:chemistry / Q000175:diagnosis*