[Recovery rate in chemotherapy of glanders].
It was shown that out of all the studied methods for the estimation of the recovery rate in animals with experimental malleus the solid-phase enzyme immunoassay with parallel growing of the test material and subsequent isolation of the antigens and L-forms proved to be the most efficient. In addition to the routine criteria of the recovery the malleinic test was a valuable diagnostic means for the estimation of the recovery rate and the efficacy of the antibacterial drugs in a model of guinea pigs. The immunological investigations revealed a dependence of the host sanation on the term of the animal chemotherapy. There was detected no L-transformation of Pseudomonas mallei during the treatment of the animals with experimental malleus with combinations of sulfanilamides with trimethoprim (biseptol and sulfaton) or rifampicin which was evident of their high sanation activity and safety in comparison to sulfamonomethoxin used alone.
Batmanov
V P
VP
Iliukhin
V I
VI
Lozovaia
N A
NA
Iakovlev
A T
AT
D000818:Animals; D000900:Anti-Bacterial Agents; D006224:Cricetinae; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005896:Glanders / Q000188:drug therapy*; D006168:Guinea Pigs; D007118:Immunoassay; D008647:Mesocricetus; D011549:Pseudomonas / Q000187:drug effects* / Q000472:pathogenicity; D012698:Serologic Tests; D014170:Transformation, Genetic; D016896:Treatment Outcome; D014774:Virulence
D000900:Anti-Bacterial Agents
Izuchenie stepeni izlechennosti pri khimioterapii éksperimental'nogo sapa.