title: On the mechanism of ventricular defibrillation.
abstract: The mechanism of ventricular defibrillation can be considered at many different levels. The highest level is considered at strength of the shock given through the defibrillation electrodes. At the next level, the mechanism of defibrillation can be examined in terms of the electrical field that the shock produces throughout the ventricles. Other levels include the effects this electric field has on the activation sequences and on the cellular action potentials that either initiate or inhibit the early sites of activation following the shock. Yet another level considers the mechanism by which the shock field initiates new action potentials or prolongs the action potential by changing the transmembrane potential during the shock. Finally, the subcellular level is considered, which involves the response of the individual ion channels to the shock. This review gives a brief overview of some salient features of defibrillation at each of these mechanistic levels.
authors.affiliation: Department of Medicine, University of Alabama at Birmingham 35294, USA.
authors.forename: G P
authors.initials: GP
authors.lastname: Walcott
authors.forename: S B
authors.initials: SB
authors.lastname: Knisley
authors.forename: X
authors.initials: X
authors.lastname: Zhou
authors.forename: J C
authors.initials: JC
authors.lastname: Newton
authors.forename: R E
authors.initials: RE
authors.lastname: Ideker
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D004554:Electric Countershock / Q000379:methods*; D017097:Electric Impedance / Q000627:therapeutic use; D006801:Humans; D008955:Models, Cardiovascular; D014693:Ventricular Fibrillation / Q000503:physiopathology* / Q000628:therapy