Central noradrenergic & dopaminergic modulation of brewer's yeast-induced inflammation & nociception in rats.
The possibility of central noradrenergic and dopaminergic modulation of Brewer's yeast-induced peripheral inflammation was investigated in rats. Centrally administered noradrenaline (NA), amphetamine, which liberates NA and dopamine in the central nervous system and L-dopa, the precursor of dopamine significantly suppressed paw oedema. Conversely, the beta-adrenoceptor blocker, propranolol, catecholaminergic neuron degenerator, 6-hydroxydopamine (6-OHDA), dopaminergic antagonist, haloperidol and dopamine synthesis inhibitor, alpha-methyl para tyrosine (AMPT) augmented paw oedema. In addition, 6-OHDA and haloperidol produced significant reduction in pain threshold. The results of this study indicate that central NA and dopamine exert inhibitory effects on Brewer's yeast-induced peripheral inflammation.
Hore
S K
SK
Division of Pharmacology & Toxicology, Indian Veterinary Research Institute, Izatnagar.
Dumka
V K
VK
Kumar
D
D
Tripathi
H C
HC
Tandan
S K
SK
D000661:Amphetamine / Q000008:administration & dosage*; D000818:Animals; D004298:Dopamine / Q000502:physiology*; D007249:Inflammation / Q000503:physiopathology*; D008297:Male; D009638:Norepinephrine / Q000008:administration & dosage*; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012441:Saccharomyces cerevisiae; D013566:Sympathomimetics / Q000008:administration & dosage*
D013566:Sympathomimetics; D000661:Amphetamine; D004298:Dopamine; D009638:Norepinephrine