title: Immunogenicity of influenza vaccine (1993-94 winter season) in HIV-seropositive and -seronegative ex-intravenous drug users.
abstract: The humoral response (haemagglutination inhibiting antibodies) to trivalent split influenza vaccine for the 1993-94 winter season (A/Beijing/32/92 (H3N2), A/Singapore/6/86 (H1N1) and B/Panama/45/90) was evaluated in a group of young HIV-seropositive ex-intravenous heroin users and compared with responses measured in HIV-seronegative individuals with a similar history. HIV-negative volunteers showed an overall positive response suggesting that previous heroin use did not influence their humoral response to influenza vaccine. Comparable results were obtained in HIV-positive subjects with CD4+ lymphocyte counts > 500 microliters-1, whereas impaired reactivity was found in HIV-positive volunteers with CD4+ counts < 500 microliters-1. Booster vaccination did not increase antibody levels in any of the groups studied, although the data did not exclude a positive influence of a second vaccine dose on persistence of antibody at 120 days after the first dose. No significant changes were observed in p24 antigenemia levels in HIV-positive individuals after vaccination.
authors.affiliation: Department of Hygiene, University of Perugia, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Iorio
authors.forename: A
authors.initials: A
authors.lastname: Alatri
authors.forename: D
authors.initials: D
authors.lastname: Francisci
authors.forename: R
authors.initials: R
authors.lastname: Preziosi
authors.forename: M
authors.initials: M
authors.lastname: Neri
authors.forename: I
authors.initials: I
authors.lastname: Donatelli
authors.forename: M R
authors.initials: MR
authors.lastname: Castrucci
authors.forename: L R
authors.initials: LR
authors.lastname: Biasio
authors.forename: C
authors.initials: C
authors.lastname: Tascini
authors.forename: R
authors.initials: R
authors.lastname: Iapoce
authors.forename: P
authors.initials: P
authors.lastname: Pierucci
authors.forename: F
authors.initials: F
authors.lastname: Baldelli
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000096:biosynthesis; D018791:CD4 Lymphocyte Count; D005260:Female; D015483:HIV Antibodies / Q000097:blood; D016655:HIV Core Protein p24 / Q000097:blood; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D018023:HIV Seronegativity / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary; D007252:Influenza Vaccines / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D015819:Substance Abuse, Intravenous / Q000150:complications*
chemical_list: D000914:Antibodies, Viral; D015483:HIV Antibodies; D016655:HIV Core Protein p24; D007252:Influenza Vaccines