title: Early death during initial chemotherapy of squamous cell carcinoma of the oro- or hypopharynx.
abstract: Neoadjuvant chemotherapy produces high response rates in squamous cell carcinoma of the head and neck without increasing the survival time. Furthermore authors have observed a death rate of about 5% (up to 10%) during chemotherapy. A series of patients with an oro- or hypo-pharynx cancer, were retrospectively divided into two groups on the basis of a short (< or = 2 months) or long (> or = 2 years) survival time. Clinical, tumoral and usual biological data from either group were compared. By univariate analysis, obesity index, hemoglobin, albumin concentrations and mononuclear cell counts were lower in patients with a short survival time compared with those in the other group. On the contrary, polymorphonuclear cell and platelet counts were higher. Infection appeared to be more frequent for patients with a poor prognosis without being entirely responsible for early death. By multivariate analysis, obesity index and platelet count were both independent variables associated with prognosis. These results call for further investigation of cardiac function, inflammatory, nutritional and immunological status of patients with squamous cell carcinoma of the head and neck who were given initial chemotherapy, particularly Cisplatin and Fluorouracil.
authors.affiliation: Institut Jean Godinot, Service de Médecine Interne Oncologique, Reims, France.
authors.forename: K
authors.initials: K
authors.lastname: Moutel
authors.forename: S
authors.initials: S
authors.lastname: Nasca
authors.forename: X
authors.initials: X
authors.lastname: Panis
authors.forename: D
authors.initials: D
authors.lastname: Lebrun
authors.forename: J C
authors.initials: JC
authors.lastname: Merol
authors.forename: P
authors.initials: P
authors.lastname: Coninx
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects; D002423:Cause of Death; D006801:Humans; D007013:Hypopharynx; D007822:Laryngeal Neoplasms / Q000188:drug therapy* / Q000401:mortality*; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced; D009959:Oropharyngeal Neoplasms / Q000188:drug therapy* / Q000401:mortality*; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents