Changes in cerebral blood flow velocity in healthy young men during overnight sleep and while awake.
Using transcranial Doppler ultrasonography, we measured in 6 healthy young men cerebral blood flow velocity (CBFV) in the middle cerebral artery as well as oxygen saturation by a non-invasive method. Continuous recordings were taken starting from a point before the onset of sleep, throughout the duration of normal nighttime sleep, ending after awakening. During stages 2, 3 and 4, CBFV was approximately 15% lower than during the waking period preceding sleep. CBFV during rapid eye movement sleep did not differ from the presleep waking value, whereas the postsleep waking value was 6.6% lower. In 5 subjects CBFV showed a transient rise after sleep onset. Oxygen saturation was lower during sleep than during waking.
Kuboyama
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T
Department of Neurosurgery, Ohmihachiman City Hospital, Shiga, Japan.
Hori
A
A
Sato
T
T
Mikami
T
T
Yamaki
T
T
Ueda
S
S
D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology*; D001921:Brain / Q000098:blood supply* / Q000378:metabolism; D002245:Carbon Dioxide / Q000378:metabolism; D006801:Humans; D008297:Male; D010100:Oxygen / Q000378:metabolism; D012890:Sleep / Q000502:physiology*; D017585:Ultrasonography, Doppler, Transcranial; D014851:Wakefulness / Q000502:physiology
D002245:Carbon Dioxide; D010100:Oxygen