13C editing of glutamate in human brain using J-refocused coherence transfer spectroscopy at 4.1 T.
The method of single quantum 13C editing is analyzed and implemented with water suppressed J-refocused coherence transfer spectroscopy. Analysis of the 13C inversion pulse demonstrates that it is optimally placed into the second echo of the J-refocused sequence. We have used this method to acquire 13C-edited spectra of glutamate from phantoms and in vivo. The turnover of 13C4-labeled glutamate in human brain in vivo was observed in parasagittal gray matter using a volume head coil at 4.1 T with a time resolution of 5.3 min.
Pan
J W
JW
Department of Neurology, University of Alabama at Birmingham 35294, USA.
Mason
G F
GF
Vaughan
J T
JT
Chu
W J
WJ
Zhang
Y
Y
Hetherington
H P
HP
D001921:Brain / Q000378:metabolism*; D002247:Carbon Isotopes; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*
D002247:Carbon Isotopes; D018698:Glutamic Acid