title: Primary cutaneous Langerhans cell histiocytosis treated with photochemotherapy.
abstract: A 23-year-old man with Langerhans cell histiocytosis presented with asymptomatic, purplish, slightly scaly, confluent papules of one year's duration. Histological studies of biopsy specimens revealed a dense infiltrate of histiocytic mononuclear cells beneath the epidermis; these cells reacted strongly with anti-S-100 antibodies. Extensive investigations failed to detect systemic involvement. He was treated with repeated oral 8-methoxypsoralen (8-MOP) plus ultraviolet A (PUVA) therapy three times a week for two months and then once or twice with maintenance phototherapy. The lesions did not recur during the four-month follow-up period.
authors.affiliation: Department of Dermatology, Seoul National University, College of Medicine, Korea.
authors.forename: O S
authors.initials: OS
authors.lastname: Kwon
authors.forename: K H
authors.initials: KH
authors.lastname: Cho
authors.forename: K Y
authors.initials: KY
authors.lastname: Song
mesh_terms: D000284:Administration, Oral; D000328:Adult; D004817:Epidermis / Q000473:pathology; D005500:Follow-Up Studies; D006644:Histiocytes / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D008730:Methoxsalen / Q000008:administration & dosage / Q000627:therapeutic use; D011701:PUVA Therapy; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000627:therapeutic use; D009418:S100 Proteins / Q000032:analysis; D012871:Skin Diseases / Q000188:drug therapy* / Q000473:pathology
chemical_list: D017319:Photosensitizing Agents; D009418:S100 Proteins; D008730:Methoxsalen