title: Role of surgery in the treatment of recurrent esophageal cancer.
abstract: Neoplastic recurrence is the most common cause of death after surgery for esophageal cancer. The Authors review the therapeutic options evaluating in terms of palliation of dysphagia and complication and mortality rates. Prognostic factors and mechanisms determining the recurrence are also reviewed. A strategy for a rational approach in the management of recurrent esophageal cancer emerges from both the literature and their own experience. Notwithstanding the small life span of these patients, the treatment of esophageal obstruction is mandatory. The therapeutic options that be considered are: palliative resection, surgical bypass, laser therapy, intubation, radiotherapy. The site of obstruction, the presence of metastasis, the general status can lead to the optimal choice. In terms of palliation of dysphagia the surgical approach seems to obtain the best results, even if high complication and mortality rates have been reported. Bypass is the second surgical choice when applicable. The other non-surgical modalities have been administered in large series of patients with good results. Combination therapies can obtain better results.
authors.affiliation: Third Department of Surgery, Regina Elena Cancer Institute, Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Carlini
authors.forename: F
authors.initials: F
authors.lastname: Grauso
authors.forename: P
authors.initials: P
authors.lastname: Perri
authors.forename: R
authors.initials: R
authors.lastname: Pasquali Lasagni
authors.forename: L
authors.initials: L
authors.lastname: Piarulli
authors.forename: A
authors.initials: A
authors.lastname: Cavallari
authors.forename: P
authors.initials: P
authors.lastname: Bruno
authors.forename: A
authors.initials: A
authors.lastname: Benaglia
authors.forename: V
authors.initials: V
authors.lastname: Cerasoli
authors.forename: N
authors.initials: N
authors.lastname: Campioni
mesh_terms: D003680:Deglutition Disorders / Q000209:etiology / Q000601:surgery; D004938:Esophageal Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007442:Intubation, Intratracheal; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D010166:Palliative Care