title: Quantitative structure-activity relationship (QSAR) study of polyhydroxyxanthones.
abstract: In the present study 13C-chemical shift additivity rules are developed for polyhydroxyxanthones with antituberculotic activity against Mycobacterium tuberculosis. QSAR investigations are performed by correlating 13C-chemical shifts and calculated dipole moments of several 1,3-substituted polyhydroxyxanthones with their antituberculotic activity and by using the CoMFA approach as a three-dimensional QSAR method.
authors.affiliation: Pharmaceutical Institute, University of Freiburg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Ungwitayatorn
authors.forename: M
authors.initials: M
authors.lastname: Pickert
authors.forename: A W
authors.initials: AW
authors.lastname: Frahm
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry* / Q000494:pharmacology*; D002247:Carbon Isotopes; D009682:Magnetic Resonance Spectroscopy; D013329:Structure-Activity Relationship; D014966:Xanthenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000995:Antitubercular Agents; D002247:Carbon Isotopes; D014966:Xanthenes