[The activity of trypsin and proteolytic inhibitors in complicated forms of appendicitis in children].
The activity of trypsin, alpha 1-proteinase inhibitor, and alpha 2-macroglobulin (MG) was measured in the blood plasma of patients with destructive appendicitis and localized and generalized peritonitis during admission to hospital and for 3 weeks after surgery. A deficit of MG was found in all forms of these diseases. A decreased activity of MG in the blood plasma is apparently a risk factor for emergency inflammatory diseases of abdominal organs. After appendectomy a more demonstrative index of patient's status is trypsin activity, an increase of which is most of all expressed in generalized peritonitis. Quantitative assessment of the trypsin-inhibitor system activity before and after surgery is necessary for a more accurate diagnosis and for monitoring the quality of treatment.
Sukhanova
G A
GA
Shalbueva
N I
NI
Shalygin
V A
VA
D000293:Adolescent; D001064:Appendicitis / Q000150:complications / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D004796:Clinical Enzyme Tests; D006552:Hernia, Inguinal / Q000175:diagnosis; D006554:Hernia, Umbilical / Q000175:diagnosis; D006801:Humans; D010447:Peptide Hydrolases / Q000097:blood*; D010538:Peritonitis / Q000175:diagnosis / Q000209:etiology; D011184:Postoperative Period; D014357:Trypsin / Q000097:blood*
D010447:Peptide Hydrolases; D014357:Trypsin
Aktivnost' tripsina i ingibitorov proteoliza pri oslozhnennykh formakh appenditsita u deteĭ.