title: Long- and short-term effects of transmyocardial laser revascularization in acute myocardial ischemia.
abstract: OBJECTIVE
  This study examined the effect of transmyocardial laser revascularization (TMLR) on infarct size and global and regional left ventricular (LV) function.
  
  
  METHODS
  Acute ischemia was induced in 24 dogs by ligating the left anterior descending artery. TMLR was done through a left thoracotomy in 12 dogs. The 12 control dogs had ligation only. Global and regional LV function were measured before ligation, then at 6 hours or 3 months after ligation. We calculated the volumetric ratio of damaged myocardium to myocardium at risk (Vd/Vr).
  
  
  RESULTS
  At 6 hours, global compensation despite regional dyskinesia was universal; Vd/Vr was the same in control and TMLR dogs. At 3 months, global function during stress was significantly higher in TMLR dogs than in control dogs (P < .05); regional contractions were synergic only in TMLR dogs; mean Vd/Vr was significantly lower in TMLR dogs.
  
  
  CONCLUSIONS
  TMLR limits infarct expansion and improves long-term global and regional function after acute ischemia.
authors.affiliation: Cardiovascular Research Laboratory, Texas Heart Institute, Houston 77030, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Kadipasaoglu
authors.forename: S
authors.initials: S
authors.lastname: Pehlivanoglu
authors.forename: J L
authors.initials: JL
authors.lastname: Conger
authors.forename: E
authors.initials: E
authors.lastname: Sasaki
authors.forename: D H
authors.initials: DH
authors.lastname: de Villalobos
authors.forename: M
authors.initials: M
authors.lastname: Cloy
authors.forename: V
authors.initials: V
authors.lastname: Piluiko
authors.forename: F J
authors.initials: FJ
authors.lastname: Clubb
authors.forename: D A
authors.initials: DA
authors.lastname: Cooley
authors.forename: O H
authors.initials: OH
authors.lastname: Frazier
mesh_terms: D000818:Animals; D003326:Coronary Circulation; D004285:Dogs; D053685:Laser Therapy; D017202:Myocardial Ischemia / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D009204:Myocardial Revascularization / Q000379:methods; D009206:Myocardium / Q000473:pathology; D016277:Ventricular Function, Left