Receptor-regulated ion channels.
Recent advances in the study of receptor-regulated ion channels include the cloning of the genes encoding three types of potassium channel that are favorite targets of receptors for transmitters and hormones. Studies of these channels have also provided a strong indication that G-protein betagamma subunits may gate ion channels via direct protein-protein interactions. Similarities between channel regulation by natriuretic peptides and channel regulation by secreted peptide products of the Alzheimer's beta-amyloid precursor protein offer hints for the existence of a receptor for the latter. There are also other novel examples of channel regulation in excitable and nonexcitable cells, including liver cells and blood cells.
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Howard Hughes Medical Institute, Department of Physiology, Biochemistry, University of California San, Francisco, CA 94143-0724, USA. gkw@itsa.ucsf.edu
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D000818:Animals; D004594:Electrophysiology; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D015640:Ion Channel Gating; D007473:Ion Channels / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*
D007473:Ion Channels; D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins