title: Effects of lidoflazine on left ventricular function in patients.
abstract: OBJECTIVE
  The present study evaluated the effects of the nucleoside transport inhibitor, lidoflazine, at a dose of 1 mg/kg, on left ventricular function.
  
  
  METHODS
  Patients were randomly assigned to receive either lidoflazine or saline in a double-blind manner.
  
  
  METHODS
  A university hospital.
  
  
  METHODS
  The study was performed in 32 patients scheduled for elective coronary artery bypass surgery.
  
  
  METHODS
  Left ventricular pressures were measured with fluid-filled catheters. Data were digitally recorded during pressure elevation induced by tilt-up of the legs. Transgastric short-axis echocardiographic views of the left ventricle were simultaneously recorded on videotape. Systolic function was evaluated with the slope (Ees, mmHg/mL) of the systolic pressure-volume relationship. Diastolic function was evaluated with the chamber stiffness constant (Kc, mmHg/mL) of the diastolic pressure-volume relationship. Cardiac function was assessed at baseline and after administration of either lidoflazine (group A [n = 16]) or placebo (group B [n = 16]). Data were compared using two-factor analysis of variance.
  
  
  RESULTS
  At baseline, diastolic and systolic function were comparable in both groups. Lidoflazine increased Kc from 0.079 +/- 0.015 to 0.125 +/- 0.017 mmHg/mL and decreased Ees from 2.481 +/- 0.213 to 1.217 +/- 0.211 mmHg/mL (p = 0.009 and p = 0.004, respectively). None of these changes occurred when placebo was administered.
  
  
  CONCLUSIONS
  Administration of lidoflazine before the start of cardiopulmonary bypass impaired left ventricular systolic function but also increased diastolic stiffness.
authors.affiliation: Department of Anesthesiology, University Hospital of Antwerp, Belgium.
authors.forename: S G
authors.initials: SG
authors.lastname: De Hert
authors.forename: I E
authors.initials: IE
authors.lastname: Rodrigus
authors.forename: L R
authors.initials: LR
authors.lastname: Haenen
authors.forename: P W
authors.initials: PW
authors.lastname: Ten Broecke
authors.forename: C J
authors.initials: CJ
authors.lastname: Boeckxstaens
authors.forename: T C
authors.initials: TC
authors.lastname: Gillebert
mesh_terms: D000368:Aged; D001026:Coronary Artery Bypass; D004311:Double-Blind Method; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008013:Lidoflazine / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D014665:Vasodilator Agents / Q000494:pharmacology*; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D014665:Vasodilator Agents; D008013:Lidoflazine