title: [Echographic and ERCP-manometric study of gallbladder and Oddi's sphincter behavior in biliary colic in patients with cholelithiasis. Effects of cerulein].
abstract: In a previous study, we have shown that caerulein relieves biliary colic pain in gallstone patients. This study was initiated to determine gallbladder and sphincter of Oddi behaviour during biliary colic and their response to caerulein. In 10 gallstone patients gallbladder volume was measured by real-time ultrasonography during a biliary colic episode and 72 hours after cessation of pain, before and after caerulein administration. Basal sphincter of Oddi pressure was determined by CPRE manometry in 10 gallstone patients during biliary colic and three days after cessation of pain, before and after caerulein. The results of this study show that, during biliary colic, gallbladder volume is 8 times greater than in the post-colic state. Basal sphincter of Oddi pressure was also significantly higher during biliary colic than in the post-colic state. Caerulein relieved in all cases the biliary colic pain while reducing gallbladder volume and decreasing the sphincter of Oddi.
authors.affiliation: II Clinica Chirurgica, Università degli Studi di Roma La Sapienza.
authors.forename: G
authors.initials: G
authors.lastname: Pizzuto
authors.forename: D
authors.initials: D
authors.lastname: Surgo
authors.forename: L
authors.initials: L
authors.lastname: Nasorri
authors.forename: R
authors.initials: R
authors.lastname: Marsico
authors.forename: V
authors.initials: V
authors.lastname: Tretola
authors.forename: L
authors.initials: L
authors.lastname: Raparelli
authors.forename: E
authors.initials: E
authors.lastname: Grasso
authors.forename: A
authors.initials: A
authors.lastname: Materia
authors.forename: N
authors.initials: N
authors.lastname: Basso
mesh_terms: D000328:Adult; D002108:Ceruletide / Q000627:therapeutic use*; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002769:Cholelithiasis / Q000188:drug therapy* / Q000503:physiopathology*; D003085:Colic / Q000188:drug therapy* / Q000503:physiopathology*; D003627:Data Interpretation, Statistical; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D009803:Sphincter of Oddi / Q000503:physiopathology*; D014463:Ultrasonography
chemical_list: D005765:Gastrointestinal Agents; D002108:Ceruletide
vernacular_title: Studio ecografico e CPRE-manometrico del comportamento della colecisti e dello sfintere di Oddi in corso di colica biliare in pazienti con colelitiasi. Effetto della ceruleina.