In hepatoma cell lines restored lipid peroxidation affects cell viability inversely to aldehyde metabolizing enzyme activity.
Canuto
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RA
Dipartimento di Scienze Cliniche e Biologiche, Università di Torino, Ospedale S. Luigi, Torino, Italy.
Ferro
M
M
Maggiora
M
M
Federa
R
R
Brossa
O
O
Bassi
A M
AM
Lindahl
R
R
Muzio
G
G
D000444:Aldehyde Dehydrogenase / Q000378:metabolism*; D000449:Aldehyde Reductase / Q000378:metabolism*; D000447:Aldehydes / Q000494:pharmacology; D000818:Animals; D016718:Arachidonic Acid / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D005290:Ferric Compounds / Q000494:pharmacology; D007770:L-Lactate Dehydrogenase; D015227:Lipid Peroxidation / Q000187:drug effects; D008114:Liver Neoplasms, Experimental / Q000201:enzymology* / Q000473:pathology; D016877:Oxidants / Q000494:pharmacology; D051381:Rats; D014407:Tumor Cells, Cultured
D000447:Aldehydes; D005290:Ferric Compounds; D016877:Oxidants; D016718:Arachidonic Acid; C061126:iron(III)-ascorbic acid complex; D000449:Aldehyde Reductase; D007770:L-Lactate Dehydrogenase; D000444:Aldehyde Dehydrogenase; C027576:4-hydroxy-2-nonenal; D001205:Ascorbic Acid