[The dependence of spontaneous excitation processes on the nature of the metabolic activity in early postnatal ontogeny].
The spontaneous motor experiment expression and parameters (including a number of rhythms from semisecond to semiminute ones as well as parameters of respiratory rythm) dependence of the level of activity for one of the main metabolic pathways, pentose phosphate cycle, were studied in experiments on rat puppies 2-16 days old. With the aim of the action on this pathway the system administration of pentose phosphate cycle inhibitors, hydroquinone and amphetamine, was used. As a result of the study it has been found out that pentose phosphate cycle retardation produces an antilogarithmic effect on the spontaneous excitement processes. The structure of the periodic components for the motor activity changes in accordance with the used inhibitor. It has been shown than studied physiological rhythms are not the result of interaction of the concrete neuronal structures. They are reproduced (simulated) by these concrete neuronal structures depending on passing character of the certain metabolic reactions.
Kuznetsov
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D000375:Aging / Q000187:drug effects / Q000502:physiology*; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D003864:Depression, Chemical; D004576:Electromyography; D006873:Hydroquinones / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D010427:Pentose Phosphate Pathway / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012119:Respiration / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
D006873:Hydroquinones; D000661:Amphetamine; C031927:hydroquinone
Zavisimost' protsessov spontannogo vozbuzhdeniia ot kharaktera metabolicheskoĭ aktivnosti v rannem postnatal'nom ontogeneze.