The in vitro effect of Pidotimod on some immune functions in cancer patients.
There are several reports concerning an impairment of cellular immune response in patients affected by malignant disease. The aim of this study was to evaluate the in vitro effect of Pidotimod, a synthetic biological response modifier, on some immune functions in 14 cancer patients. In particular, we showed that these subjects had a significantly reduced peripheral blood mononuclear cell (PBMC) proliferation both in response to PHA and to Con A in comparison with a group of healthy subjects. Besides, they showed a significantly reduced PBMC IL2 production, which was evaluated both through an ELISA method and a biological assay. The in vitro addition of increasing concentrations of Pidotimod (10, 25 and 50 ug/ml) was able to enhance PBMC proliferation and IL2 production significantly. However, in spite of the addition of Pidotimod, both immune functions in our neoplastic patients did not reach normal values.
Di Renzo
M
M
Department of Clinical Immunology, University of Siena, Italy.
Pasqui
A L
AL
Bruni
F
F
Saletti
M
M
Bova
G
G
Chiarion
C
C
Girardello
R
R
Ferrì
P
P
Auteri
A
A
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007155:Immunologic Factors / Q000276:immunology* / Q000494:pharmacology*; D007376:Interleukin-2 / Q000096:biosynthesis / Q000172:deficiency / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D008213:Lymphocyte Activation; D008297:Male; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology*; D053778:Thiazolidines
D000276:Adjuvants, Immunologic; D007155:Immunologic Factors; D007376:Interleukin-2; D013844:Thiazoles; D053778:Thiazolidines; C064893:pidotimod; D011761:Pyrrolidonecarboxylic Acid