Patterns of oncogene activation in human neuroblastoma cells.
Human neuroblastoma is the most frequent solid tumor in children. Recent studies suggest that a multiplicity of genomic alterations contributes to neuroblastoma, the most frequent and well studied being deletion of the short arm of chromosome 1 and amplification of N-MYC. We here present and discuss different patterns of oncogene activation including, amplification of N-MYC, duplication of N-MYC and amplification of MDM2.
Corvi
R
R
Deursches Krebsforschungszentrum, Abteilung Zytogenetik, Heidelberg, Germany.
Savelyeva
L
L
Schwab
M
M
D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D016259:Genes, myc / Q000235:genetics; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics; D009447:Neuroblastoma; D009687:Nuclear Proteins; D009857:Oncogenes / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics; D051736:Proto-Oncogene Proteins c-mdm2
D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2