title: Effect of peripheral nerve injury on nuclear magnetic resonance relaxation times of rat skeletal muscle.
abstract: OBJECTIVE
  The authors evaluate the changes in magnetic resonance (MR) relaxation times of rat skeletal muscles in vivo after nerve injury and during neural recovery, and determine the major determinants of relaxation times.
  
  
  METHODS
  Magnetic resonance relaxation times, blood volume, and water and fat content were examined after nerve injury and during recovery with time course.
  
  
  RESULTS
  Nerve injury led to longer T2 values compared with controls, but there were no significant changes in T1 values. After the initial prolongation of T2 after nerve injury, no changes were observed. Neural recovery resulted in a return of T2 values to normal. The time course of changes in blood volume was similar to that of changes in T2, and T2 values were correlated strongly with 19-fluorine-MR spectroscopy estimates of blood volume (r2 = 0.94).
  
  
  CONCLUSIONS
  T2 values may be useful to monitor recovery after nerve injury and may be related to the blood volume in skeletal muscle.
authors.affiliation: Department of Orthopedic Surgery, School of Medicine, University of Tokushima, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
authors.forename: T
authors.initials: T
authors.lastname: Ikata
authors.forename: H
authors.initials: H
authors.lastname: Takai
authors.forename: S
authors.initials: S
authors.lastname: Takata
authors.forename: M
authors.initials: M
authors.lastname: Ishikawa
authors.forename: T
authors.initials: T
authors.lastname: Sogabe
authors.forename: K
authors.initials: K
authors.lastname: Koga
mesh_terms: D000818:Animals; D001810:Blood Volume; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009121:Muscle Denervation; D018482:Muscle, Skeletal / Q000294:innervation / Q000378:metabolism* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000293:injuries*