[The immunochemical detection of the site of duodenase synthesis and secretion: its functional role in the proteolytic carrier system].
A new protease (duodenase) was discovered, isolated from the bovine duodenum, and purified. The protease manifested two types of specific features: (1) dual tripsin- and chymotripsin-like specifics in respect to exoproteolysis of peptides and their derivatives, and (2) conformational specifics in respect to endoproteolysis of peptides. The duodenase seems to be synthetized and secreted in the duodenal (Brunner) glands.
Morozov
I A
IA
Vorotyntseva
T I
TI
Zamolodchikova
T S
TS
D000818:Animals; D002011:Brunner Glands / Q000201:enzymology / Q000648:ultrastructure; D002417:Cattle; D004789:Enzyme Activation; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000201:enzymology / Q000648:ultrastructure; D008297:Male; D016253:Microscopy, Immunoelectron / Q000379:methods; D010447:Peptide Hydrolases / Q000378:metabolism*; D012697:Serine Endopeptidases / Q000096:biosynthesis* / Q000378:metabolism / Q000502:physiology
D010447:Peptide Hydrolases; D012697:Serine Endopeptidases; C078261:duodenase
Immunokhimicheskoe vyiavlenie mesta sinteza i sekretsii duodenazy: ee funktsional'naia rol' v proteoliticheskom konveĭre.