[Third generation cephalosporins (cefoperazone, cefotaxime, ceftazidime and ceftriaxone) in the prevention and treatment of experimental plague in albino mice].
Strains of the plague microbe of different origin were found to by highly susceptible to the third generation cephalosporins such as cefoperazone, cefotaxime, ceftazidime and ceftriaxone. The MICs ranged form 0.012 to 0.5 microgram/ml. A comparative study on the efficacy of the 3rd generation cephalosporins in the treatment of experimental plague in albino mice revealed that the use of cefoperazone, cefotaxime, ceftazidime and ceftriaxone in the therapy of etiotropic plague was promising. Ceftriaxone, an antibiotic with prolonged action, which was the most efficient in the experiments on the laboratory animals was shown to be the drug of choice among the 3rd generation cephalosporins.
Ryzhko
I V
IV
Tsuraeva
R I
RI
Pasiukov
V V
VV
Samokhodkina
E D
ED
Shcherbaniuk
A I
AI
D000818:Animals; D002438:Cefoperazone / Q000627:therapeutic use; D002439:Cefotaxime / Q000627:therapeutic use; D002442:Ceftazidime / Q000627:therapeutic use; D002443:Ceftriaxone / Q000627:therapeutic use; D002511:Cephalosporins / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D051379:Mice; D008826:Microbial Sensitivity Tests; D010930:Plague / Q000188:drug therapy* / Q000517:prevention & control; D016896:Treatment Outcome; D015010:Yersinia pestis / Q000187:drug effects
D002511:Cephalosporins; D002443:Ceftriaxone; D002438:Cefoperazone; D002442:Ceftazidime; D002439:Cefotaxime
Tsefalosporiny tret'ego pokoleniia (tsefoperazon, tsefotaksim, tseftazidim, tseftriakson) v profilaktike i lechenii éksperimental'noĭ chumy belykh mysheĭ.