An essential cysteine (Cys-227) in human carbonyl reductase is involved in glutathione binding.
Tinguely
J
J
Department of Clinical Chemistry, University of Berne, Inselspital, Switzerland.
Ernst
E
E
Wermuth
B
B
D000429:Alcohol Oxidoreductases / Q000737:chemistry* / Q000378:metabolism*; D000449:Aldehyde Reductase; D000074408:Aldo-Keto Reductases; D001665:Binding Sites; D003545:Cysteine; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005978:Glutathione / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D016297:Mutagenesis, Site-Directed; D017354:Point Mutation; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism
D004791:Enzyme Inhibitors; D011994:Recombinant Proteins; D000429:Alcohol Oxidoreductases; D000074408:Aldo-Keto Reductases; D000449:Aldehyde Reductase; D005978:Glutathione; D003545:Cysteine