title: [Experimental validation of the use of betamecil in ophthalmology].
abstract: Wound-healing activity of 2% betamicil ointment in comparison with the traditional stimulants of corneal repair regeneration (methyluracyl and solcoseril) was studied in experiments. The rate of epithelialization of a standard trephination wound in rabbit cornea (28 animals), mitotic activity of the anterior corneal epithelium, and strength of the regenerated tissue were assessed after use of different stimulants and in control. A maximal positive effect of local betamicil (2% ointment) was observed: the wounds epithelialized 57% sooner than in control, but there was no reliable difference from solcoseril; the regenerate of linear corneal wound was 1.5 times stronger. Use of this ointment in ophthalmology is validated.
authors.forename: E A
authors.initials: EA
authors.lastname: Egorov
authors.forename: N B
authors.initials: NB
authors.lastname: Leonidov
authors.forename: V A
authors.initials: VA
authors.lastname: Kniazhev
authors.forename: S B
authors.initials: SB
authors.lastname: Fitilev
authors.forename: T B
authors.initials: TB
authors.lastname: Dzhafarov
authors.forename: N N
authors.initials: NN
authors.lastname: Avramenko
authors.forename: T K
authors.initials: TK
authors.lastname: Dubovaia
authors.forename: A A
authors.initials: AA
authors.lastname: Dreval'
mesh_terms: D000818:Animals; D003315:Cornea / Q000187:drug effects* / Q000502:physiology; D065306:Corneal Injuries; D004728:Endothelium, Corneal / Q000187:drug effects / Q000502:physiology; D005782:Gels; D008297:Male; D009824:Ointments; D011817:Rabbits; D012038:Regeneration / Q000187:drug effects*; D013268:Stimulation, Chemical; D013997:Time Factors; D014498:Uracil / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D005782:Gels; D009824:Ointments; D014498:Uracil; C008378:6-methyluracil
vernacular_title: Eksperiemntal'noe obosnovanie primeneniia betametsila v oftal'mologii.