Placental Na+, K+ activated ATP-ase activity in SHRSP in connection with pregnancy induced hypertension and intra-uterine growth retardation.
1. Placental Na+, K+ -ATPase activities were measured in connection with the active transport of amino acid, intra-uterine growth retardation (IUGR) or small for date infants (SFD) in salt-loaded pregnant SHRSP. 2. All parameters such as fetal weight, placental weight and Na+, K+ -ATPase activity in the placental tissue were significantly depressed in SHRSP, especially in the salt-loaded SHRSP compared with WKY. 3. Besides a decrease of blood flow, a decline of Na+, K+ -ATPase activity associated with an active transport of amino acid in the placenta would cause IUGR and SFD in the salt-loaded pregnant SHRSP. 4. Pregnant SHRSP given water containing salt would be a good model for pregnancy induced hypertension in humans.
Fuchi
I
I
Department of Obstetrics and Gynecology, Kinki University School of Medicine, Osaka-Sayama, Japan.
Higashino
H
H
Noda
K
K
Suzuki
A
A
Matsubara
Y
Y
D000818:Animals; D002561:Cerebrovascular Disorders / Q000235:genetics / Q000503:physiopathology; D005314:Embryonic and Fetal Development / Q000502:physiology; D004789:Enzyme Activation / Q000502:physiology; D005260:Female; D005317:Fetal Growth Retardation / Q000201:enzymology*; D006973:Hypertension / Q000201:enzymology*; D010920:Placenta / Q000201:enzymology*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000201:enzymology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012965:Sodium Chloride / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D012965:Sodium Chloride; D000254:Sodium-Potassium-Exchanging ATPase