title: Laryngeal radionecrosis versus recurrent cancer.
abstract: This article reviews the nature, pathogenesis, and clinical grading system of laryngeal radionecrosis. The differentiation of radiation-induced soft-tissue complications from recurrent cancer can be a difficult clinical dilemma. Conventional imagery and even biopsy results are frequently equivocal. A treatment-interventional algorithmic approach to the problem patient is presented, and the role of positron emission tomographic scanning in making this differentiation is discussed.
authors.affiliation: Department of Otolaryngology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157-1034, USA.
authors.forename: W F
authors.initials: WF
authors.lastname: McGuirt
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D007818:Laryngeal Diseases / Q000175:diagnosis*; D007822:Laryngeal Neoplasms / Q000532:radiotherapy*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D011832:Radiation Injuries / Q000175:diagnosis*; D011878:Radiotherapy / Q000009:adverse effects*; D014055:Tomography, Emission-Computed