Electrophysiological improvement after co-implantation of carbon filaments and fetal tissue in the contused rat spinal cord.
The electrophysiological integrity of the adult rat spinal cord was assessed at the lumbar, lower cervical and cortical levels after the animals sustained a severe contusion injury at the mid-thoracic level (T8) and received either carbon filament cultured with fetal spinal cord tissue implants, fetal tissue implants, or carbon filament implants alone. Somatosensory evoked potentials (SSEPs) and motor evoked potentials (MEPs) were recorded from all animal groups at the end of the 8-week survival period. The results of this study demonstrate that the spinal cord injured animals that received carbon filament cultured with fetal spinal cord tissue implants had the highest degree of electrophysiological recovery, indicating that this combination plays an important role in promoting recovery after injury.
Liu
L S
LS
Rehabilitation Research and Development Center, Hines Veterans Administration Hospital, IL 60141, USA.
Khan
T
T
Sayers
S T
ST
Dauzvardis
M F
MF
Trausch
C L
CL
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D002244:Carbon; D003288:Contusions / Q000503:physiopathology / Q000628:therapy*; D004558:Electric Stimulation; D004594:Electrophysiology; D005071:Evoked Potentials / Q000502:physiology; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D016332:Fetal Tissue Transplantation / Q000502:physiology*; D009046:Motor Neurons / Q000502:physiology; D019736:Prostheses and Implants; D051381:Rats; D013116:Spinal Cord / Q000166:cytology / Q000637:transplantation*; D013119:Spinal Cord Injuries / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*
D002244:Carbon