Diabetic scleredema: a case report and biochemical analysis for glycosaminoglycans.
We report a patient with the typical lesions of diabetic scleredema. Histological findings of the involved skin were thickening of the dermis, depositions of mucins, and fibrosis. Biochemical analysis revealed an increase in glycosaminoglycans in the involved skin as well as in the cutaneous lupus mucinosis. Mucinous materials were composed of hyaluronic acid.
Kobayashi
T
T
Division of Dermatology, Tokyo Daini National Hospital, Higashigaoka, Meguro, Japan.
Yamasaki
Y
Y
Watanabe
T
T
D002809:Chondroitin Sulfates / Q000032:analysis; D003871:Dermatan Sulfate / Q000032:analysis; D048909:Diabetes Complications; D005260:Female; D005355:Fibrosis; D006025:Glycosaminoglycans / Q000032:analysis*; D006801:Humans; D006820:Hyaluronic Acid / Q000032:analysis; D008875:Middle Aged; D017520:Mucinoses / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D009077:Mucins / Q000032:analysis; D012592:Scleredema Adultorum / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D012867:Skin / Q000378:metabolism* / Q000473:pathology
D006025:Glycosaminoglycans; D009077:Mucins; D003871:Dermatan Sulfate; D006820:Hyaluronic Acid; D002809:Chondroitin Sulfates