title: Treatment options in struvite stones.
abstract: Urinary calculi have plagued man over the centuries. The epidemiology and pathogenesis of infection have been studied. The curative treatment remains problematic. Without therapy, a vicious cycle of stone formation occurs. This results in renal damage and even death. Multimodality therapy is the key. Nonoperative treatment leads to progressive renal damage. The combination of maximal surgical ablation and medical therapy is synergistic. The combination of PCNL-ESWL has not appeared to produce ill effects. PCNL-ESWL is a less morbid surgical alternative than open surgical procedures. Adjunctive medical therapy, such as culture-specific antibiotics and urease inhibitors, complements surgical ablation by reducing the morbidity with persistent UTIs and stone recurrence. The urologist today must approach struvite staghorns with a vast armamentarium of surgical and medical techniques. Each patient requires a unique solution.
authors.affiliation: Department of Surgery (Urology), University of Kansas School of Medicine, Kansas City, USA.
authors.forename: L P
authors.initials: LP
authors.lastname: Wang
authors.forename: H Y
authors.initials: HY
authors.lastname: Wong
authors.forename: D P
authors.initials: DP
authors.lastname: Griffith
mesh_terms: D006801:Humans; D007669:Kidney Calculi / Q000737:chemistry / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy*; D008096:Lithotripsy; D017616:Magnesium Compounds; D009403:Nephrostomy, Percutaneous; D010710:Phosphates; D000069877:Struvite; D014510:Urease / Q000037:antagonists & inhibitors; D014556:Urine
chemical_list: D017616:Magnesium Compounds; D010710:Phosphates; D000069877:Struvite; D014510:Urease