title: Respective role of TNF receptors in the development of experimental cerebral malaria.
abstract: The respective role of the two receptors of TNF in experimental cerebral malaria (CM) was investigated. During CM, a significant upregulation of TNF-receptor 2 (TNFR2), but not of TNFR1, was found in brain microvessels of susceptible, but not resistant mice. Mice genetically deficient for TNFR2 (Tnfr2null) were significantly protected from CM, while TNFR1-deficient (Tfnr1null) mice were as susceptible as wild-type mice. The protection of Tnfr2null mice could be explained by their absence of ICAM-1 upregulation and leukocyte sequestration, known to occur in brain microvessels of CM-susceptible animals.
authors.affiliation: Dept. of Anaesthesiology, Pharmacology and Surgical Intensive Care, University Medical Center, Geneva, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Lucas
authors.forename: J N
authors.initials: JN
authors.lastname: Lou
authors.forename: P
authors.initials: P
authors.lastname: Juillard
authors.forename: M
authors.initials: M
authors.lastname: Moore
authors.forename: H
authors.initials: H
authors.lastname: Bluethmann
authors.forename: G E
authors.initials: GE
authors.lastname: Grau
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D016779:Malaria, Cerebral / Q000209:etiology* / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008833:Microcirculation / Q000276:immunology / Q000378:metabolism; D010963:Plasmodium falciparum; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology*; D015854:Up-Regulation / Q000276:immunology
chemical_list: D018124:Receptors, Tumor Necrosis Factor