Cell death in the inner ear associated with aging is apoptosis?
Programmed cell death (apoptosis) in the inner ear of senescence-accelerated mouse was identified using specific labeling of fragmented DNA (the TUNEL method). In spite of some inter-individual differences, the apoptotic cells were predominantly found in the phylogenetically newer part of the inner ear, the cochlea and the saccules. In the saccules, sensory hair cells as well as supporting cells were positively labeled. In the cochlea, positive staining was detected in inner and outer hair cells, pillar cells, Deiters' cells, interdental cells, the stria vascularis (marginal cells, intermediate cells, basal cells), and cells in Reissner's membrane. The present results suggest that age-related cell death, which may cause hearing impairment and dysequilibrium, is due to apoptosis occurring in the inner ear.
Usami
S
S
Dept. of Otorhinolaryngology, Hirosaki University School of Medicine, Japan. usami@cc.hirosaki-u.ac.jp
Takumi
Y
Y
Fujita
S
S
Shinkawa
H
H
Hosokawa
M
M
D000375:Aging / Q000235:genetics / Q000502:physiology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D003051:Cochlea / Q000166:cytology / Q000502:physiology; D053938:DNA Fragmentation; D007758:Ear, Inner / Q000166:cytology*; D006199:Hair Cells, Auditory, Inner / Q000502:physiology; D051379:Mice; D008815:Mice, Inbred Strains; D008856:Microscopy, Fluorescence; D012444:Saccule and Utricle / Q000166:cytology / Q000502:physiology