title: Action of elgodipine on atherosclerosis development, cell growth, and oncogene expression in vascular smooth muscle cells.
abstract: 1. Elgodipine (ELG) had no significant effect on aortic content of cholesterol, plasma cholesterol, or triglycerides concentrations in cholesterol-fed rabbits. However, ELG administration produced a dose-dependent and significant reduction of calcium content of the aorta. 2. In vitro studies showed that ELG was able to inhibit vascular smooth muscle proliferation through a mechanism independent of the expression of the transcription factors c-fos and c-jun.
authors.affiliation: Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Del Rio
authors.forename: E
authors.initials: E
authors.lastname: Ruiz
authors.forename: T
authors.initials: T
authors.lastname: Tejerina
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects* / Q000378:metabolism; D001161:Arteriosclerosis / Q000517:prevention & control; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000032:analysis; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004095:Dihydropyridines / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects; D006937:Hypercholesterolemia / Q000097:blood / Q000378:metabolism; D008074:Lipoproteins / Q000097:blood; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis; D011817:Rabbits; D014280:Triglycerides / Q000097:blood
chemical_list: D002121:Calcium Channel Blockers; D002791:Cholesterol, Dietary; D004095:Dihydropyridines; D008074:Lipoproteins; D011518:Proto-Oncogene Proteins; D014280:Triglycerides; C063839:elgodipine; D002118:Calcium