title: Controlled pilot study of rapid amphotericin B infusions.
abstract: This pilot study compared the toxicity of a one hour with a four hour amphotericin B infusion in children. There were more severe chills in the former group on the first day of infusion, and more hypotension in the latter group over the study duration.
authors.affiliation: Department of Paediatrics, Hospital for Sick Children, Toronto, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Dele Davies
authors.forename: S M
authors.initials: SM
authors.lastname: King
authors.forename: J
authors.initials: J
authors.lastname: Doyle
authors.forename: A
authors.initials: A
authors.lastname: Matlow
authors.forename: G
authors.initials: G
authors.lastname: Koren
authors.forename: R
authors.initials: R
authors.lastname: Hamilton
authors.forename: C
authors.initials: C
authors.lastname: Portwine
mesh_terms: D000293:Adolescent; D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage* / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D010865:Pilot Projects; D012768:Shivering
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000666:Amphotericin B