p53 DO-1 immunohistochemical overexpression in premalignant and malignant cervical lesions.
One hundred-fourteen cervical lesions, including paraffin sections from benign, premalignant and malignant cervical tissue specimens were examined immunohistochemically for overexpression of p53 protein, using the p53 DO-1 monoclonal antibody (MoAb). p53 overexpression was observed in 66% of premalignant cervical lesions and in 90% of invasive squamous cell carcinomas. The difference in p53 positive lesions of premalignant and malignant cervical lesions was statistically very significant (p < 0.001) and the difference between CIN1 and CIN2 and CIN3 statistically significant (p < 0.01). Our results indicate that p53 overexpression may be involved at an early stage in cervical carcinogenesis.
Skopelitou
A
A
Pathology Department of University Medical School of Ioannina, Greece.
Kamina
S
S
Krikoni
O
O
Alexopoulou
V
V
Agnantis
N J
NJ
D000911:Antibodies, Monoclonal / Q000276:immunology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D011230:Precancerous Conditions / Q000737:chemistry*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis* / Q000276:immunology; D002583:Uterine Cervical Neoplasms / Q000737:chemistry*; D002578:Uterine Cervical Dysplasia / Q000737:chemistry
D000911:Antibodies, Monoclonal; D016159:Tumor Suppressor Protein p53