Three new oleanane saponins from Zanha africana.
Three new saponins, zanhasaponins, A, B, and C, were isolated from the MeOH extract of the root bark of Zanha africana and were, respectively, identified by spectroscopic methods as 3-O-beta-D-glucuronopyranosyl-2 beta,16 alpha-dihydroxyolean-12-ene-23,28- dioic acid 28-O-alpha-L-rhamnopyranosyl(1-->2)-alpha-L-rhamnopyranoside (1); 3-O-beta-D-glucuronopyranosyl-2 beta,16 alpha-dihydroxyolean-12-ene- 23,28-dioic acid 28-O-beta-D-xylopyranosyl(1-->2)-alpha-L-rhamnopyranosyl(1-->2)-alpha-L- rhamnopyranoside (2); and 3-O-beta-D-glucuronopyranosyl-2 beta,16 alpha-dihydroxyolean-12-ene- 23,28-dioic acid 28-O-beta-D-xylopyranosyl(1-->3)-beta-D-xylopyranosyl (1-->2)-alpha-L-rhamnopyranosyl(1-->2)-alpha-L-rhamnopyranoside (3). These saponins proved to be effective in a model of topical inflammation induced by phorbol ester. The cyclitols quebrachitol, pinitol, and bornesitol were also identified.
Cuéllar
M J
MJ
Department de Farmacologia, Facultat de Farmàcia, Universitat de València, Spain.
Giner
R M
RM
Recio
M C
MC
Just
M J
MJ
Máñez
S
S
Ríos
J L
JL
Bilia
A R
AR
Msonthi
J
J
Hostettmann
K
K
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D004423:Ear / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity; D014197:Trees / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D012503:Saponins; D013755:Tetradecanoylphorbol Acetate