Marigenol-concentrates comprising Taxol and/or Taxan esters as active substances.
Marigen is a Swiss Research Company based in Riehen (Canton of Basle). It has developed and tested a Solubilization System for its phytosteryl ester compounds having antitumor and antiviral/virucidal activity. By formulating spontaneously dispersible concentrates, which comprise such compounds, it is now possible to produce thermodynamically stable, aqueous ultramicroemulsions which achieve outstanding bioavailability and bio-reactivity for the active principles comprised in these Marigenol-Concen-trates. As a consequence, unwanted side-effects are drastically reduced in therapeutical use or even completely absent, and the economy of the system permits a remarkable optimization of the dose-efficacy relationship and hence also of drug safety.
Eugster
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C
Marigen S.A., Riehen.
Rivara
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Forni
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G
Vai
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S
D000470:Alkaloids / Q000008:administration & dosage* / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry*; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004655:Emulsions; D006801:Humans; D017239:Paclitaxel / Q000008:administration & dosage* / Q000737:chemistry*; D014677:Pharmaceutical Vehicles / Q000008:administration & dosage* / Q000737:chemistry*; D010840:Phytosterols / Q000737:chemistry; D012995:Solubility; D043823:Taxoids
D000470:Alkaloids; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D004655:Emulsions; D014677:Pharmaceutical Vehicles; D010840:Phytosterols; D043823:Taxoids; C073950:baccatin III; D017239:Paclitaxel