Outcome of acetaminophen overdose in pediatric patients and factors contributing to hepatotoxicity.
Seventy-three medical records of pediatric patients admitted for acetaminophen overdose were reviewed. Twenty-eight patients (39%) had severe liver toxic effects, and six of them underwent liver transplantation. Multiple miscalculated overdoses given by parents, with delay in therapy, are risk factors and the major cause of overdose in children 10 years of age or younger.
Rivera-Penera
T
T
University of California, Medical Center, Los Angeles 90095, USA.
Gugig
R
R
Davis
J
J
McDiarmid
S
S
Vargas
J
J
Rosenthal
P
P
Berquist
W
W
Heyman
M B
MB
Ament
M E
ME
D000082:Acetaminophen / Q000008:administration & dosage / Q000009:adverse effects*; D000293:Adolescent; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000009:adverse effects*; D002140:California / Q000453:epidemiology; D056486:Chemical and Drug Induced Liver Injury / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D062787:Drug Overdose / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D005260:Female; D006801:Humans; D007223:Infant; D016031:Liver Transplantation; D008297:Male; D008508:Medication Errors / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen