Relationship between membrane properties and cell size of developing rat genioglossal motoneurons studied in vitro.
Electrical properties and morphology of 21 genioglossal motoneurons were measured in a slice preparation of the rat brainstem at four different postnatal ages. The motoneurons labeled with neurobiotin were reconstructed and quantified in three-dimensional space. There was no strong correlation found between the input resistance or membrane time constant and the total membrane surface area. We conclude that there is no electrical property of these developing motoneurons that can accurately predict their anatomical size.
Núñez-Abades
P A
PA
Department of Neuroscience, University of Pittsburgh, PA 15260, USA.
Cameron
W E
WE
D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000502:physiology; D001933:Brain Stem / Q000166:cytology; D048429:Cell Size; D002478:Cells, Cultured; D004594:Electrophysiology; D009046:Motor Neurons / Q000166:cytology* / Q000502:physiology*; D009132:Muscles / Q000294:innervation*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014059:Tongue / Q000294:innervation*