title: Genetic analysis of a meningococcal population based on polymorphism of the pilA-pilB locus: a molecular approach for meningococcal epidemiology.
abstract: The genetic relationships between 88 meningococcal strains were analyzed by using the polymorphism of the pilA gene and the multilocus enzyme electrophoresis. While a good agreement was observed, correlation with antigenic formula (serogroup, serotype, and serosubtype) was incomplete. The inadequacy of serological classification alone in outbreak surveillance may be overcome by DNA-based approaches.
authors.affiliation: Unité des Neisseria, Institut Pasteur, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Guibourdenche
authors.forename: D
authors.initials: D
authors.lastname: Giorgini
authors.forename: A
authors.initials: A
authors.lastname: Guèye
authors.forename: M
authors.initials: M
authors.lastname: Larribe
authors.forename: J Y
authors.initials: JY
authors.lastname: Riou
authors.forename: M K
authors.initials: MK
authors.lastname: Taha
mesh_terms: D000483:Alleles; D001426:Bacterial Proteins / Q000235:genetics; D015373:Bacterial Typing Techniques; D004268:DNA-Binding Proteins / Q000235:genetics; D004196:Disease Outbreaks; D036781:Fimbriae Proteins; D005798:Genes, Bacterial; D006801:Humans; D008589:Meningococcal Infections / Q000453:epidemiology / Q000382:microbiology; D017720:Molecular Epidemiology; D009345:Neisseria meningitidis / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D010088:Oxidoreductases; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012703:Serotyping
chemical_list: D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D036781:Fimbriae Proteins; D010088:Oxidoreductases; C068255:pilB protein, Bacteria