title: Effects of colectomy on gallbladder motility in patients with ulcerative colitis.
abstract: In order to gain insight into the possible mechanisms involved in gallstone formation in colectomized ulcerative colitis patients, we studied gallbladder motility by means of ultrasonography in three groups of subjects: controls (N = 40) and ulcerative colitis patients without (N = 30) and with (N = 20) colectomy. Impaired gallbladder emptying after a liquid fatty meal stimulus was observed in ulcerative colitis patients with colectomy compared with those obtained in ulcerative colitis patients without colectomy and controls (P = 0.001). The maximum percentage of gallbladder emptying also, was significantly lower (59.8%) than those seen in ulcerative colitis patients without colectomy (74.5%) and controls (77.8%) (P = 0.001). Diminished gallbladder emptying with ensuing stasis might be a contributory factor to the increased prevalence of gallstones in colectomized patients.
authors.affiliation: Department of Gastroenterology, University of São Paulo (USP) Medical School, Brazil.
authors.forename: A O
authors.initials: AO
authors.lastname: Damião
authors.forename: A M
authors.initials: AM
authors.lastname: Sipahi
authors.forename: D P
authors.initials: DP
authors.lastname: Vezozzo
authors.forename: A L
authors.initials: AL
authors.lastname: Gonçalves
authors.forename: A
authors.initials: A
authors.lastname: Habr-Gama
authors.forename: M G
authors.initials: MG
authors.lastname: Teixeira
authors.forename: J T
authors.initials: JT
authors.lastname: Fukushima
authors.forename: A A
authors.initials: AA
authors.lastname: Laudanna
mesh_terms: D000328:Adult; D003082:Colectomy / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D016473:Gallbladder Emptying; D005746:Gastric Emptying; D006801:Humans; D008297:Male