title: Centration and fixation of silicone intraocular lenses: clinicopathological findings in human autopsy eyes.
abstract: OBJECTIVE
  To analyze centration and fixation of three-piece and one-piece silicone intraocular lenses (IOLs) in human autopsy eyes.
  
  
  METHODS
  Center for Intraocular Lens Research, Medical University of South Carolina, Charleston.
  
  
  METHODS
  Thirty eyes among those submitted to the center between 1986 and 1994 were evaluated. The globes were sectioned at the equatorial plane and photographed from a posterior view. Gross examination was performed to determine IOL type, fixation, centration, and additional pathology. The results were compared with those of a control group of autopsy eyes implanted with one-piece and three-piece poly(methyl methacrylate) (PMMA) IOLs. The control group matched the silicone group in patient age, fixation site, and duration of implantation.
  
  
  RESULTS
  Twenty-three eyes (79.3%) had three-piece silicone IOLs and 7 eyes (20.7%), one-piece plate IOLs. Average patient age in the three-piece group was 77.3 years +/- 6.7 (SD) and in the one-piece group, 74.3 +/- 3.8 years. The 30 IOLs were symmetrically fixated in the bag. Average decentration of the three-piece and one-piece IOLs did not differ significantly, 0.37 +/- 0.31 mm and 0.26 +/- 0.13 mm, respectively (P = .37). There was also no significant difference in decentration between the silicone groups and the PMMA groups (P = .93).
  
  
  CONCLUSIONS
  Centration and fixation of silicone IOLs were equivalent to those of standard PMMA IOLs.
authors.affiliation: Storm Eye Institute, Department of Ophthalmology, Medical University of South Carolina, Charleston 29425-2236, USA.
authors.forename: G U
authors.initials: GU
authors.lastname: Auffarth
authors.forename: C
authors.initials: C
authors.lastname: McCabe
authors.forename: M
authors.initials: M
authors.lastname: Wilcox
authors.forename: J C
authors.initials: JC
authors.lastname: Sims
authors.forename: T A
authors.initials: TA
authors.lastname: Wesendahl
authors.forename: D J
authors.initials: DJ
authors.lastname: Apple
mesh_terms: D000368:Aged; D000869:Anterior Eye Segment / Q000473:pathology*; D002102:Cadaver; D006801:Humans; D007910:Lenses, Intraocular; D008768:Methylmethacrylates; D011680:Pupil; D012189:Retrospective Studies; D012826:Silicone Elastomers
chemical_list: D008768:Methylmethacrylates; D012826:Silicone Elastomers