Arousal and inhibition of human NK cells.
NK cells express receptors for polymorphic MHC class I molecules that inhibit killing of potential target cells bearing appropriate class I allotypes. Here we review the membrane receptors on human NK cells that are known to initiate cell-mediated cytotoxicity and demonstrate regulation of these responses by the killer cell inhibitory (KIR) receptors.
Lanier
L L
LL
DNAX Research Institute of Molecular and Cellular Biology, Department of Human Immunology, Palo Alto, CA 94304, USA. lanier@dnax.org
Corliss
B
B
Phillips
J H
JH
D000595:Amino Acid Sequence; D000950:Antigens, Ly; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects / Q000378:metabolism*; D037181:Lectins, C-Type; D008213:Lymphocyte Activation / Q000187:drug effects; D008562:Membrane Glycoproteins / Q000502:physiology*; D008969:Molecular Sequence Data; D011971:Receptors, Immunologic / Q000502:physiology*; D055630:Receptors, NK Cell Lectin-Like; D013491:Suppressor Factors, Immunologic / Q000502:physiology*
D000950:Antigens, Ly; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; D055630:Receptors, NK Cell Lectin-Like; D013491:Suppressor Factors, Immunologic