Novel saponins hainaneosides A and B isolated from Marsdenia hainanensis.
Novel saponins possessing fertility-regulating activity, hainaneosides A (1) and B (2), have been isolated from the twigs and stems of Marsdenia hainanensis, and their structures have been elucidated unambiguously as 12-nicotinoyl sarcostin-3-O-beta-D-glucopyranosyl-(1-->4)-3-O-methyl-6-deoxy-bet a-D- allopyranosyl-(1-->4)-beta-D-oleandropyranosyl-(1-->4)-beta-D- cymaropyranosyl-(1-->4)-beta-D-cymaropyranoside and 12-nicotinoyl-20-cinnamoyl sarcostin-3-O-beta-D-glucopyranosyl-(1-->4)-3-O-methyl-6-deoxy-bet a-D- allopyranosyl-(1-->4)-beta-D-oleandropyranosyl-(1-->4)-beta-D-c ymaropyranoside using NMR spectroscopic techniques and chemical transformations.
Ma
B
B
Department of Pharmacy, Tongji Hospital, Tongji Medical University, Wuhan, China.
Fang
T
T
Ma
K
K
Ni
J
J
Wu
H
H
Ding
W P
WP
Jiang
C
C
D000020:Abortifacient Agents, Nonsteroidal / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D009682:Magnetic Resonance Spectroscopy; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D010944:Plants / Q000737:chemistry*; D051381:Rats; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000020:Abortifacient Agents, Nonsteroidal; D012503:Saponins; C104802:hainaneoside B; C104801:hainaneoside A; D009828:Oleanolic Acid