Killing mechanisms of cytotoxic lymphocytes.
Killer lymphocytes are primary immune effectors of virus, certain bacteria, and tumor immunity and play a role in autoimmunity and transplant rejection. This article reviews progress in deciphering the mechanisms by which they kill target cells through induction of apoptosis by either the secretory, perforin/granzyme-based pathway or the nonsecretory pathway, (i.e., by triggering the cell-surface death receptor Fas (CD95) by the membrane-bound Fas ligand of the killer).
Berke
G
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Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D006801:Humans; D013602:T-Lymphocytes, Cytotoxic; D019014:fas Receptor / Q000276:immunology*
D019014:fas Receptor