Electric current density imaging of mice tumors.
The use of electric current density imaging (CDI) to map spatial distribution of electric currents through tumors is presented. Specifically, a method previously tested on phantoms was implemented in vivo and in vitro for mapping electric current pulses of the same order of magnitude (j approximately 2500 A/m2) as in electrochemotherapy through T50/80 mammary carcinomas, B-16 melanomas and SA-1 sarcomas. A technically simplified method of electric current density imaging is discussed as well. Three geometries of electrodes (flat-flat, point-point, point-flat) indicate altered electric current distribution for the same tumor. This indicates that the method can be used for monitoring the effects of electrochemotherapy as a function of electrode geometry.
Sersa
I
I
Jozef Stefan Institute, University of Ljubijana, Slovenia.
Beravs
K
K
Dodd
N J
NJ
Zhao
S
S
Miklavcic
D
D
Demsar
F
F
D000818:Animals; D001943:Breast Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D004558:Electric Stimulation; D004566:Electrodes; D005260:Female; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008819:Mice, Nude; D012878:Skin Neoplasms / Q000737:chemistry / Q000175:diagnosis*