title: Genetic controls of susceptibility and resistance to 4-nitroquinoline 1-oxide-induced tongue carcinomas in rats.
abstract: We analyzed the incidence of infiltrative mass-type tongue carcinomas (IMTC) induced in 550 rats by continuous oral administration of 0.001% 4-nitroquinoline 1-oxide solution for 180 days. The study included various crosses of susceptible Dark-Agouti rats (DA) and resistant Wistar/Furth rats (WF). DA showed a 93.6% incidence of IMTC measuring more than 5 mm in their largest diameter, while WF showed only a 4% incidence. Reciprocal F1 and F2 hybrids mated by DA and WF showed 47.5% and 45.8% incidences, respectively. Meanwhile, reciprocal backcrossed hybrids to DA and WF showed 73.7%, and 24.6% incidences, respectively. Segregation of the incidences suggests that there are two autosomal dominant genes, one linked to the susceptibility of DA and the other to the resistance of WF.
authors.affiliation: Department of Oral Pathology, Kagoshima University Dental School, Sakuragaoka.
authors.forename: M
authors.initials: M
authors.lastname: Kitano
authors.forename: Y
authors.initials: Y
authors.lastname: Hirayama
authors.forename: J
authors.initials: J
authors.lastname: Tanuma
authors.forename: H
authors.initials: H
authors.lastname: Matsuuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Miura
authors.forename: T J
authors.initials: TJ
authors.lastname: Li
authors.forename: I
authors.initials: I
authors.lastname: Semba
authors.forename: H S
authors.initials: HS
authors.lastname: Ozaki
authors.forename: T
authors.initials: T
authors.lastname: Kokubu
authors.forename: H
authors.initials: H
authors.lastname: Hatano
authors.forename: M
authors.initials: M
authors.lastname: Tada
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Shisa
mesh_terms: D015112:4-Nitroquinoline-1-oxide / Q000633:toxicity*; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D003043:Cocarcinogenesis; D004198:Disease Susceptibility; D019008:Drug Resistance, Neoplasm; D005260:Female; D008297:Male; D051381:Rats; D011920:Rats, Inbred WF; D014062:Tongue Neoplasms / Q000139:chemically induced* / Q000235:genetics*
chemical_list: D002273:Carcinogens; D015112:4-Nitroquinoline-1-oxide