Juvenile glaucoma linked to the GLC1A gene on chromosome 1q in a Panamanian family.
OBJECTIVE
To characterize clinically and genetically autosomal dominant juvenile-onset primary open-angle glaucoma in a Panamanian family.


METHODS
Twenty members of a six-generation family underwent ophthalmologic examination and genetic screening with markers near the GLC1A gene on chromosome 1q.


RESULTS
Linkage analysis disclosed evidence linking primary open-angle glaucoma in this family to the GLC1A gene on chromosome 1q, with a maximum lod score of 3.75 for marker D1S431 at an estimated recombination fraction of 0.00.


CONCLUSIONS
This is the first report of a Panamanian family in which primary open-angle glaucoma is linked to the GLC1A gene on chromosome 1q.
Lichter
P R
PR
Department of Ophthalmology, University of Michigan, Ann Arbor 48105, USA.
Richards
J E
JE
Boehnke
M
M
Othman
M
M
Cameron
B D
BD
Stringham
H M
HM
Downs
C A
CA
Lewis
S B
SB
Boyd
B F
BF
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005902:Glaucoma, Open-Angle / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007429:Intraocular Pressure; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D010176:Panama; D010375:Pedigree; D014792:Visual Acuity
D005819:Genetic Markers