The HSR chromosome 1 in the house mouse, Mus musculus, from regions of the Urals polluted by mutagens.
The incidence of the HSR chromosome 1 was examined in Mus musculus musculus from 12 localities of the Middle and South Urals and Northwestern Siberia. The HSR chromosome was found in 7 localities, its frequency varying from 5 up to 18%. The HSR incidence was shown to correlate with the mean pooled frequency of aneuploidy and polyploidy in bone marrow, but not with the mean proportion of cells carrying structural chromosome aberrations. In mice heterozygous for HSR the rate of aneuploidy and polyploidy was significantly higher than in animals with standard karyotype, on average by a factor 2.35. HSRs tend to be more abundant in localities adjacent to sites of radiation incidents with contamination mainly by 90Sr.
Gileva
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EA
Institute of Plant and Animal Ecology, Russian Academy of Sciences, Ekaterinburg, Russia.
D000818:Animals; D002871:Chromosome Banding; D004785:Environmental Pollutants / Q000633:toxicity*; D005838:Genotype; D051379:Mice; D009153:Mutagens / Q000633:toxicity*; D010641:Phenotype; D012426:Russia; D013194:Staining and Labeling
D004785:Environmental Pollutants; D009153:Mutagens