Actions of lectins from the mushroom Tricholoma mongolicum on macrophages, splenocytes and life-span in sarcoma-bearing mice.
Two lectins isolated from the mushroom Tricholoma mongolicum stimulated the production of nitrite ions by macrophages in normal and tumor-bearing mice. Both lectins exhibited negligible mitogenic activity toward T-cells or splenocytes from normal mice in vitro when compared with Con A. Similarly, T-cells from sarcoma-bearing mice treated with the lectins did not exhibit a mitogenic response different from that of the control. However, T-cells from normal lectin-treated mice demonstrated a reduced mitogenic response when compared with the control. In mice the growth of sarcoma 180 cells in the peritoneal cavity was inhibited and the life-span was prolonged by the two lectins.
Wang
H X
HX
Department of Biology, Chinese University of Hong Kong, Shatin, Hong Kong.
Ng
T B
TB
Ooi
V E
VE
Liu
W K
WK
Chang
S T
ST
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D037102:Lectins / Q000494:pharmacology*; D008213:Lymphocyte Activation; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008934:Mitogens / Q000494:pharmacology; D009573:Nitrites / Q000378:metabolism; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000276:immunology; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology
D000970:Antineoplastic Agents; D037102:Lectins; D008934:Mitogens; D009573:Nitrites