Nef and PAK: virulence factor and cellular accomplice.
The Nef protein is important in HIV replication and in AIDS pathogenesis. The finding that Nef activates a member of the PAK family of protein kinases provides new insights into the mechanisms of action of this critical virulence factor.
Trono
D
D
Salk Institute for Biological Studies, La Jolla, CA 92037-1099, USA.
Wang
J K
JK
D000163:Acquired Immunodeficiency Syndrome / Q000503:physiopathology; D000818:Animals; D015693:Gene Products, nef / Q000378:metabolism*; D015754:Genes, nef; D015497:HIV-1 / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D008253:Macaca mulatta; D008954:Models, Biological; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000503:physiopathology; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000472:pathogenicity*; D014774:Virulence; D054311:nef Gene Products, Human Immunodeficiency Virus
D015693:Gene Products, nef; D054311:nef Gene Products, Human Immunodeficiency Virus; D017346:Protein Serine-Threonine Kinases