title: Absence of EBV genome in lymphoepithelioma-like carcinomas of the larynx.
abstract: Undifferentiated nasopharyngeal carcinomas are universally associated with Epstein-Barr virus (EBV). This association has been exclusively established in lymphoepithelioma-like carcinomas in some locations. The relationship between EBV and lymphoepithelioma-like carcinomas in the larynx is unknown. In none of the few laryngeal lymphoepithelioma-like carcinomas reported have EBV investigations been carried out. We present here two supraglottic laryngeal lymphoepithelioma-like carcinomas in which EBV antigens were not demonstrable using immunohistochemical and molecular methods. Our results suggest that EBV may not be involved in laryngeal lymphoepithelioma-like carcinoma at least in Western patients.
authors.affiliation: Department of Pathology, Hospital Severo Ochoa, Leganés, Spain.
authors.forename: J C
authors.initials: JC
authors.lastname: Tardío
authors.forename: E
authors.initials: E
authors.lastname: Cristóbal
authors.forename: F
authors.initials: F
authors.lastname: Burgos
authors.forename: J
authors.initials: J
authors.lastname: Menárguez
mesh_terms: D001402:B-Lymphocytes / Q000821:virology; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D004825:Epiglottis; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007633:Keratins / Q000378:metabolism; D007822:Laryngeal Neoplasms / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000821:virology; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis*; D012189:Retrospective Studies; D013601:T-Lymphocytes / Q000821:virology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D012367:RNA, Viral; D016159:Tumor Suppressor Protein p53; D007633:Keratins