title: Singlet oxygen and superoxide characteristics of a series of novel asymmetric photosensitizers.
abstract: The singlet oxygen quantum yields and superoxide quantum yields for a series of novel compounds based on an asymmetrical protoporphyrin molecule have been examined. Electron spin resonance was used to measure superoxide yield and time resolved luminescence for singlet oxygen. A comparison between these results and previously published cell survival data was carried out. A broad association was found between singlet oxygen quantum yield and clonogenic cell kill.
authors.affiliation: Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Manchester, UK.
authors.forename: A K
authors.initials: AK
authors.lastname: Haylett
authors.forename: F I
authors.initials: FI
authors.lastname: McNair
authors.forename: D
authors.initials: D
authors.lastname: McGarvey
authors.forename: N J
authors.initials: NJ
authors.lastname: Dodd
authors.forename: E
authors.initials: E
authors.lastname: Forbes
authors.forename: T G
authors.initials: TG
authors.lastname: Truscott
authors.forename: J V
authors.initials: JV
authors.lastname: Moore
mesh_terms: D003497:Cyclic N-Oxides / Q000737:chemistry; D004578:Electron Spin Resonance Spectroscopy; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry*; D011789:Quantum Theory; D017382:Reactive Oxygen Species; D013113:Spin Labels; D019097:Spin Trapping; D013481:Superoxides / Q000737:chemistry*
chemical_list: D003497:Cyclic N-Oxides; D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species; D013113:Spin Labels; D013481:Superoxides; C017245:5,5-dimethyl-1-pyrroline-1-oxide