title: Novel patterns of p53 abnormality in breast cancer from Taiwan: experience from a low-incidence area.
abstract: Among 114 breast cancers in Taiwan, the prevalence of p53 mutation (22.8%) and p53 accumulation (38.3%) was similar to that in high-incidence areas. However, novel patterns of p53 abnormalities, including unique sites or types of mutation (i.e. an excessive proportion of G:C to A:T transition at CpG site), and accumulation of wild-type p53 either within nuclear or cytoplasmic compartments were noted. These may have relevance to breast cancer in Taiwan, a low-incidence area.
authors.affiliation: Cardinal Tien Hospital, Taipei, Taiwan.
authors.forename: M A
authors.initials: MA
authors.lastname: Lou
authors.forename: S L
authors.initials: SL
authors.lastname: Tseng
authors.forename: S F
authors.initials: SF
authors.lastname: Chang
authors.forename: C T
authors.initials: CT
authors.lastname: Yue
authors.forename: B L
authors.initials: BL
authors.lastname: Chang
authors.forename: C H
authors.initials: CH
authors.lastname: Chou
authors.forename: S L
authors.initials: SL
authors.lastname: Yang
authors.forename: B H
authors.initials: BH
authors.lastname: Teh
authors.forename: C W
authors.initials: CW
authors.lastname: Wu
authors.forename: C Y
authors.initials: CY
authors.lastname: Shen
mesh_terms: D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics*; D005091:Exons; D016158:Genes, p53; D006801:Humans; D015994:Incidence; D009154:Mutation; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D013624:Taiwan