[Interactions of adenosine with sympathetic neurotransmission in the heart].
Adenosine exerts most of its cardiac effects via direct interaction with sympathetic neurotransmission: Release of norepinephrine is inhibited in presynaptic neurons, and catecholamine-induced activation of adenylyl cyclase is inhibited in postsynaptic effector cells. While presynaptic effects fade rapidly during ischemia, postsynaptic antagonism to catecholamines remains an important protective element during sustained ischemia.
Ungerer
M
M
Medizinische Klinik II, Medizinische Universität zu Lübeck.
Richardt
G
G
D000241:Adenosine / Q000502:physiology*; D000067956:Adenylyl Cyclase Inhibitors; D000262:Adenylyl Cyclases / Q000502:physiology; D000818:Animals; D004562:Electrocardiography; D004837:Epinephrine / Q000502:physiology; D006321:Heart / Q000294:innervation*; D006801:Humans; D017202:Myocardial Ischemia / Q000503:physiopathology*; D009638:Norepinephrine / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology*
D000067956:Adenylyl Cyclase Inhibitors; D000262:Adenylyl Cyclases; D000241:Adenosine; D009638:Norepinephrine; D004837:Epinephrine
Interaktionen von Adenosin mit der sympathischen Neurotransmission im Herzen.