High-performance liquid chromatographic analysis of cyclosporin A and its oral solutions.
Different columns and conditions were evaluated for the HPLC analysis of cyclosporin A, its congeners and degradation products. The optimised conditions were compared with the pharmacopoeial HPLC method for cyclosporin A analysis and some modifications, applicable among others for the stability studies of oral dosage forms, are proposed.
Husek
A
A
Galena Co., Department of Analytical Chemistry, Opava-Komárov, Czech Republic.
D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D016572:Cyclosporine / Q000032:analysis*; D007202:Indicators and Reagents; D008969:Molecular Sequence Data; D012996:Solutions
D007202:Indicators and Reagents; D012996:Solutions; D016572:Cyclosporine