title: Three new oleanane saponins from Zanha africana.
abstract: Three new saponins, zanhasaponins, A, B, and C, were isolated from the MeOH extract of the root bark of Zanha africana and were, respectively, identified by spectroscopic methods as 3-O-beta-D-glucuronopyranosyl-2 beta,16 alpha-dihydroxyolean-12-ene-23,28- dioic acid 28-O-alpha-L-rhamnopyranosyl(1-->2)-alpha-L-rhamnopyranoside (1); 3-O-beta-D-glucuronopyranosyl-2 beta,16 alpha-dihydroxyolean-12-ene- 23,28-dioic acid 28-O-beta-D-xylopyranosyl(1-->2)-alpha-L-rhamnopyranosyl(1-->2)-alpha-L- rhamnopyranoside (2); and 3-O-beta-D-glucuronopyranosyl-2 beta,16 alpha-dihydroxyolean-12-ene- 23,28-dioic acid 28-O-beta-D-xylopyranosyl(1-->3)-beta-D-xylopyranosyl (1-->2)-alpha-L-rhamnopyranosyl(1-->2)-alpha-L-rhamnopyranoside (3). These saponins proved to be effective in a model of topical inflammation induced by phorbol ester. The cyclitols quebrachitol, pinitol, and bornesitol were also identified.
authors.affiliation: Department de Farmacologia, Facultat de Farmàcia, Universitat de València, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Cuéllar
authors.forename: R M
authors.initials: RM
authors.lastname: Giner
authors.forename: M C
authors.initials: MC
authors.lastname: Recio
authors.forename: M J
authors.initials: MJ
authors.lastname: Just
authors.forename: S
authors.initials: S
authors.lastname: Máñez
authors.forename: J L
authors.initials: JL
authors.lastname: Ríos
authors.forename: A R
authors.initials: AR
authors.lastname: Bilia
authors.forename: J
authors.initials: J
authors.lastname: Msonthi
authors.forename: K
authors.initials: K
authors.lastname: Hostettmann
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D004423:Ear / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity; D014197:Trees / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D012503:Saponins; D013755:Tetradecanoylphorbol Acetate