title: Metastasizing placental site trophoblastic tumor: immunohistochemical and DNA analysis. 2 case reports and a review of the literature.
abstract: Placental-site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasia. The clinical behaviour of PSTT is usually benign, but sometimes it can be highly malignant with late recurrence and metastasis. We describe two cases of PSTT with pulmonary metastasis in patients aged 35 and 29 years respectively. The mitotic rate was elevated to 9 and 13 mitotic figures per 10 high-power fields respectively. Immunohistochemical staining showed a predominance of human placental lactogen (hPL) positive cells when compared with human chorionic gonadotropin (hCG) reactive cells in one case, and a reverse pattern in the other one. DNA measurement in one case showed an aneuploid tumor with a tetraploid DNA peak. The clinical behaviour of PSTT remains unpredictable, and there are no reliable means of predicting clinical outcome.
authors.affiliation: Institut de Pathologie Clinique, Hôpital Cantonal Universitaire de Genève, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Remadi
authors.forename: B
authors.initials: B
authors.lastname: Lifschitz-Mercer
authors.forename: H
authors.initials: H
authors.lastname: Ben-Hur
authors.forename: R
authors.initials: R
authors.lastname: Dgani
authors.forename: B
authors.initials: B
authors.lastname: Czernobilsky
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology / Q000556:secondary*; D008938:Mitosis; D009364:Neoplasm Recurrence, Local; D010928:Placental Lactogen / Q000032:analysis; D011247:Pregnancy; D018245:Trophoblastic Tumor, Placental Site / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology*; D014594:Uterine Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology*; D014625:Vaginal Neoplasms / Q000556:secondary
chemical_list: D006063:Chorionic Gonadotropin; D004273:DNA, Neoplasm; D010928:Placental Lactogen