title: Myelodysplastic syndrome presenting as third malignancy after non-Hodgkin's lymphoma and osteosarcoma.
abstract: The patient was initially diagnosed as having non-Hodgkin's lymphoma and was cured following treatment with prednisolone, vincristine, daunorubicin, 1-asparaginase, and cyclophosphamide. Seven years and two months later, he developed osteosarcoma in his right femur. He received chemotherapy consisting of methotrexate, carboplatin, etoposide, and ifosfamide and again obtained remission. After 2 years and 7 months, however, he was found to have pancytopenia with morphological abnormalities in the erythroid and myeloid series. Diagnosis of myelodysplastic syndrome (MDS) was made. Cytogenetic analysis of bone marrow cells revealed -5 and -7, which is typical for secondary MDS. This is a rare case of third malignancy presumably caused by alkylating agents.
authors.affiliation: Department of Pediatrics, Kyoto University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kubota
authors.forename: M
authors.initials: M
authors.lastname: Sawada
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: S
authors.initials: S
authors.lastname: Koishi
authors.forename: A
authors.initials: A
authors.lastname: Kataoka
authors.forename: I
authors.initials: I
authors.lastname: Usami
authors.forename: Y W
authors.initials: YW
authors.lastname: Lin
authors.forename: A
authors.initials: A
authors.lastname: Okuda
authors.forename: Y
authors.initials: Y
authors.lastname: Akiyama
authors.forename: K
authors.initials: K
authors.lastname: Furusho
mesh_terms: D000293:Adolescent; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects; D002869:Chromosome Aberrations / Q000209:etiology; D025063:Chromosome Disorders; D002895:Chromosomes, Human, Pair 5; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D007621:Karyotyping; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000139:chemically induced / Q000175:diagnosis* / Q000235:genetics; D012516:Osteosarcoma / Q000175:diagnosis*
chemical_list: D018906:Antineoplastic Agents, Alkylating