Two thrombotic complications in a patient with active ulcerative colitis.
A 30-year-old woman is described with both a cerebral venous thrombosis and a deep vein thrombosis of her leg in association with an exacerbation of her ulcerative colitis. Laboratory investigations revealed a transient functional APC resistance, without Factor V mutation, and a mild hyperhomocysteinaemia. After colectomy the APC ratio was normal. These findings may form a partial explanation of the thrombophilia seen in some patients with active ulcerative colitis.
Gonera
R K
RK
Department of Internal Medicine, St. Elisabeth Hospital, Tilburg, Netherlands.
Timmerhuis
T P
TP
Leyten
A C
AC
van der Heul
C
C
D000328:Adult; D003093:Colitis, Ulcerative / Q000150:complications*; D005260:Female; D006710:Homocysteine / Q000378:metabolism; D006801:Humans; D011486:Protein C / Q000378:metabolism; D012851:Sinus Thrombosis, Intracranial / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D013924:Thrombophlebitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
D011486:Protein C; D006710:Homocysteine