title: Fixed drug eruption of the penis due to hydroxyzine hydrochloride.
abstract: OBJECTIVE
  To report four cases of fixed drug eruption induced by hydroxyzine hydrochloride (Otarex, Teva, Israel).
  
  
  METHODS
  Four children with restlessness who were treated with hydroxyzine hydrochloride developed fixed drug eruption of the penis. Drug discontinuation was followed by complete resolution of the skin eruption. Rechallenge resulted in the same drug rash. Macrophage migration inhibiting factor (MIF) assay with hydroxyzine hydrochloride was positive.
  
  
  CONCLUSIONS
  The pathogenesis of fixed drug eruption and the role of macrophage MIF assay in diagnosis is discussed.
  
  
  CONCLUSIONS
  A fixed drug eruption induced by hydroxyzine hydrochloride is possible, but is a rare phenomenon.
authors.affiliation: Department of Family Medicine, Sackler School of Medicine, Tel Aviv University, Petach Tikvah, Israel.
authors.forename: H A
authors.initials: HA
authors.lastname: Cohen
authors.forename: A
authors.initials: A
authors.lastname: Barzilai
authors.forename: A
authors.initials: A
authors.lastname: Matalon
authors.forename: L
authors.initials: L
authors.lastname: Harel
authors.forename: S
authors.initials: S
authors.lastname: Gross
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D003875:Drug Eruptions / Q000276:immunology; D006168:Guinea Pigs; D006801:Humans; D006919:Hydroxyzine / Q000009:adverse effects* / Q000627:therapeutic use; D007223:Infant; D008263:Macrophage Migration-Inhibitory Factors / Q000032:analysis; D008297:Male; D010413:Penis; D011595:Psychomotor Agitation / Q000188:drug therapy*
chemical_list: D014151:Anti-Anxiety Agents; D008263:Macrophage Migration-Inhibitory Factors; D006919:Hydroxyzine