title: [Nephrotic syndrome as the initial symptom of Crohn disease].
abstract: In february 1993, a now 54-year-old man presented with an increased serum-creatinine of 1.7 mg/dl known since september 1992 associated with peripheral edema. He reported painless and infrequent diarrhea during the previous 15 years. Clinically, he showed typical symptoms of a nephrotic syndrome. A renal biopsy revealed an amyloidosis. By further investigations the diagnosis of underlying Crohn's disease could be established. An ileocecal resection and a subsequent immunosuppressive therapy with azathioprine was performed. Following this procedure the serum-creatinine has meanwhile increased to 3.2 mg/dl with the proteinuria remaining stable. Furthermore, the patient developed a renal hypertension. However, at present the patient is otherwise asymptomatic and in a good general condition.
authors.affiliation: Klinik und Poliklinik für Innere Medizin I, Universität Regensburg.
authors.forename: F
authors.initials: F
authors.lastname: Kullmann
authors.forename: M
authors.initials: M
authors.lastname: Kullmann
authors.forename: H G
authors.initials: HG
authors.lastname: Leser
authors.forename: B K
authors.initials: BK
authors.lastname: Krämer
authors.forename: A J
authors.initials: AJ
authors.lastname: Riegger
authors.forename: J
authors.initials: J
authors.lastname: Schölmerich
mesh_terms: D000686:Amyloidosis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D001379:Azathioprine / Q000008:administration & dosage; D001706:Biopsy; D002432:Cecum / Q000473:pathology / Q000601:surgery; D003131:Combined Modality Therapy; D003424:Crohn Disease / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy
chemical_list: D007166:Immunosuppressive Agents; D001379:Azathioprine
vernacular_title: Nephrotisches Syndrom als Erstsymptom eines M. Crohn.