Controlled pilot study of rapid amphotericin B infusions.
This pilot study compared the toxicity of a one hour with a four hour amphotericin B infusion in children. There were more severe chills in the former group on the first day of infusion, and more hypotension in the latter group over the study duration.
Dele Davies
H
H
Department of Paediatrics, Hospital for Sick Children, Toronto, Canada.
King
S M
SM
Doyle
J
J
Matlow
A
A
Koren
G
G
Hamilton
R
R
Portwine
C
C
D000293:Adolescent; D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage* / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D010865:Pilot Projects; D012768:Shivering
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000666:Amphotericin B