Singlet oxygen and superoxide characteristics of a series of novel asymmetric photosensitizers.
The singlet oxygen quantum yields and superoxide quantum yields for a series of novel compounds based on an asymmetrical protoporphyrin molecule have been examined. Electron spin resonance was used to measure superoxide yield and time resolved luminescence for singlet oxygen. A comparison between these results and previously published cell survival data was carried out. A broad association was found between singlet oxygen quantum yield and clonogenic cell kill.
Haylett
A K
AK
Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Manchester, UK.
McNair
F I
FI
McGarvey
D
D
Dodd
N J
NJ
Forbes
E
E
Truscott
T G
TG
Moore
J V
JV
D003497:Cyclic N-Oxides / Q000737:chemistry; D004578:Electron Spin Resonance Spectroscopy; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry*; D011789:Quantum Theory; D017382:Reactive Oxygen Species; D013113:Spin Labels; D019097:Spin Trapping; D013481:Superoxides / Q000737:chemistry*
D003497:Cyclic N-Oxides; D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species; D013113:Spin Labels; D013481:Superoxides; C017245:5,5-dimethyl-1-pyrroline-1-oxide