High-lipid diet intake is a possible predisposing factor in the development of hypogonadal osteoporosis.
The effects of a high-lipid diet on the intestinal transference of Ca2+ and the activities of intestinal enzymes were studied in ovariectomized rats. The plasma Ca2+ level and urinary loss of Ca2+ were also observed. Ovariectomy decreased both alkaline phosphatase (AP) and calcium ATPase (Ca(2+)-ATPase) activity, and also reduced the mucosal transference of Ca2+ in all parts of the small intestine. Although the plasma Ca2+ level did not change significantly, the urinary loss of Ca2+ was enhanced. A high-lipid diet supplement enhanced all these parameters in ovariectomized rats. It is therefore believed that a high-lipid diet may promote osteoporosis in ovariectomized rats as the result of Ca2+ transfer and enhanced urinary Ca2+ loss.
Chanda
S
S
Department of Physiology, Presidency College, Calcutta, India.
Islam
M N
MN
Pramanik
P
P
Mitra
C
C
D000469:Alkaline Phosphatase / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D000252:Calcium-Transporting ATPases / Q000502:physiology; D004041:Dietary Fats / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007421:Intestine, Small / Q000201:enzymology*; D015663:Osteoporosis, Postmenopausal / Q000201:enzymology / Q000503:physiopathology*; D010052:Ovariectomy; D011446:Prospective Studies; D051381:Rats; D017208:Rats, Wistar
D004041:Dietary Fats; D000469:Alkaline Phosphatase; D000252:Calcium-Transporting ATPases; D002118:Calcium