title: Use of intravenous immunoglobulin to prevent or treat infections in persons with immune deficiency.
abstract: Intravenous immunoglobulin (IVIG) concentrates were originally developed as replacement therapy for individuals with primary deficiencies of the immune system. However, in various well-designed, controlled clinical trials, the ability of IVIG to prevent and possibly treat infections in patients with secondary immune deficiencies has also been considered. In this review, we briefly consider these different applications and suggest whether the data are sufficient to employ IVIG in these clinical settings.
authors.affiliation: International Quantitative Consultants, Inc., Glendale, California 91203, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Lee
authors.forename: R P
authors.initials: RP
authors.lastname: Gale
authors.forename: P L
authors.initials: PL
authors.lastname: Yap
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000628:therapy; D002986:Clinical Trials as Topic; D006801:Humans; D007116:Immunization, Passive / Q000379:methods*; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000628:therapy*; D007262:Infusions, Intravenous; D009894:Opportunistic Infections / Q000276:immunology / Q000628:therapy*; D016896:Treatment Outcome