title: Three cases of contact allergy after chemical burns from methylchloroisothiazolinone/methylisothiazolinone: one with concomitant allergy to methyldibromoglutaronitrile/phenoxyethanol.
abstract: BACKGROUND
  Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) is known to be a contact sensitizer. It is used extensively in cosmetic products in low concentrations. Occupational exposure usually occurs with concentrated solutions and results in a different reaction pattern.
  
  
  RESULTS
  Three workers developed chemical burns and subsequent sensitization after exposure to concentrated solutions of MCI/MI. One patient was also occupationally sensitized to methyldibromoglutaronitrile/phenoxyethanol.
  
  
  CONCLUSIONS
  Exposure to concentrated solutions of some allergens can be severely irritating in the occupational setting and can probably induce sensitization.
authors.affiliation: Cleveland Clinic Foundation, Department of Dermatology, OH, USA.
authors.forename: E J
authors.initials: EJ
authors.lastname: Primka
authors.forename: J S
authors.initials: JS
authors.lastname: Taylor
mesh_terms: D000328:Adult; D002057:Burns, Chemical / Q000150:complications* / Q000209:etiology; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000209:etiology*; D004202:Disinfectants / Q000009:adverse effects*; D006801:Humans; D007221:Industry; D008297:Male; D008875:Middle Aged; D009570:Nitriles / Q000009:adverse effects*; D010328:Patch Tests; D013844:Thiazoles / Q000009:adverse effects*
chemical_list: D004202:Disinfectants; D009570:Nitriles; D013844:Thiazoles; C037057:Kathon 886; C039411:1,2-dibromo-2,4-dicyanobutane