Binding of monoclonal antibodies to platelet glycoproteins Ib and IIb/IIIa in uremic patients.
In this study, we have found a reduced binding of monoclonal antibodies (CD42b and CD41a) to glycoproteins Ib and IIb/IIIa of uremic platelets. Presumably, this was due to the altered structure of the sugary part of these glycoproteins. Change in the glycoprotein composition may have effected the disturbed adhesion and aggregation of uremic platelets.
Komarnicki
M
M
Department of Hematology, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
Kaźmierczak
M
M
de Mezer-Dambek
M
M
D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000378:metabolism*; D001792:Blood Platelets / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D009844:Oligosaccharides / Q000737:chemistry; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D011485:Protein Binding; D006435:Renal Dialysis; D014511:Uremia / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D009844:Oligosaccharides; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D019038:Platelet Glycoprotein GPIb-IX Complex