Influence of auxiliary substances on the release of heptacaine from the drug form.
In the course of the drug form development of heptacaine potential local anaesthetic, the influence of auxiliary substances on the heptacaine release and its local anaesthetic effect was studied. The obtained results show that the following auxiliary substances are optimal: a) 0.3-1.2% solution hydroxypropylmethyl cellulose for 0.025% eye drops, which have the fastest onset of the local anaesthetic effect in the hamster's eye, b) hydroxyethyl cellulose containing 0.5% heptacaine and 10% glycerol or propylene glycol for hydrogels, c) cocoa oil without and with Dimodan S for suppositories.
Vitková
Z
Z
Department of Gelanic Pharmacy, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic.
Gardavská
K
K
Cizmárik
J
J
Rak
J
J
D000772:Anesthesia, Local; D000779:Anesthetics, Local / Q000008:administration & dosage*; D000818:Animals; D002482:Cellulose / Q000031:analogs & derivatives; D006224:Cricetinae; D003692:Delayed-Action Preparations; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives; D009883:Ophthalmic Solutions; D010880:Piperidines / Q000008:administration & dosage*; D012996:Solutions; D013997:Time Factors
D000779:Anesthetics, Local; D003692:Delayed-Action Preparations; D009883:Ophthalmic Solutions; D010880:Piperidines; D012996:Solutions; D065347:Hypromellose Derivatives; C013549:heptacaine; D002482:Cellulose; C002283:hydroxyethylcellulose; D008747:Methylcellulose