Biosynthesis of thromboxane by snake (Elaphe obsoleta) erythrocytes and the requirement of eicosanoid production for blood clotting.
Lower vertebrates provide important insights into the evolution of eicosanoid synthesis and function. Whole snake blood, purified nucleated erythrocytes, and isolated leukocytes activated by clotting or A23187 produced thromboxane, PGE2, and 5-lipoxygenase products. Indomethacin's complete inhibition of clotting suggests eicosanoids produced by these cells are important in snake blood hemostasis.
Herman
C A
CA
Department of Biology, New Mexico State University, Las Cruces 88003, USA. cherman@nmsu.edu
Wang
X
X
Gronert
K
K
D000818:Animals; D001094:Arachidonate 5-Lipoxygenase / Q000032:analysis; D001777:Blood Coagulation; D000001:Calcimycin; D015777:Eicosanoids / Q000096:biosynthesis; D004912:Erythrocytes / Q000378:metabolism*; D007962:Leukocytes / Q000378:metabolism; D012911:Snakes / Q000097:blood*; D013931:Thromboxanes / Q000096:biosynthesis*
D015777:Eicosanoids; D013931:Thromboxanes; D000001:Calcimycin; D001094:Arachidonate 5-Lipoxygenase