title: Managing the risk of thrombosis in the perioperative period in patients undergoing orthopedic and trauma surgery with low-molecular-weight heparin: enoxaparin.
abstract: Patients undergoing arthroplastic surgery of the lower limbs and those with multiple injuries have a high risk of thromboembolism. Enoxaparin is a highly effective antithrombotic drug that is well tolerated and without the need for monitoring. Numerous controlled trials in these patient groups have demonstrated enoxaparin to be at least as effective as heparin in reducing the occurrence of deep vein thrombosis while showing a tendency towards lower risk of bleeding complications; therefore, enoxaparin is recommended as thromboprophylaxis in patients undergoing major hip or knee surgery or suffering from multiple trauma.
authors.affiliation: Department of Orthopedics, Hillerød Hospital, Denmark.
authors.forename: M R
authors.initials: MR
authors.lastname: Lassen
authors.forename: L C
authors.initials: LC
authors.lastname: Borris
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D001842:Bone and Bones / Q000293:injuries*; D017984:Enoxaparin / Q000627:therapeutic use*; D006470:Hemorrhage / Q000209:etiology; D006622:Hip Prosthesis; D006801:Humans; D007595:Joint Prosthesis; D007720:Knee Prosthesis; D011183:Postoperative Complications / Q000517:prevention & control*; D013923:Thromboembolism / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin