title: Sodium profiling in elderly haemodialysis patients.
abstract: Intradialytic vascular instability continues to be one of the most frequent complications in elderly haemodialysis patients. Signs of impending hypotension such as sweating, apprehension, tachycardia, nausea, or vomiting may be infrequent in the geriatric population. The onset of hypotension in the elderly may be sudden and profound and may lead to serious consequences such as myocardial infarction, stroke, or aspiration if not treated promptly. Prevention of vascular instability is extremely important in the elderly. Avoiding rapid ultrafiltration sedatives, or antihypertensive medications and food intake may be beneficial. Optimal dialysate composition (dialysate sodium, bicarbonate, and calcium concentration) is important. Dialysate sodium profiling may be useful in the elderly to reduce intradialytic hypotension. Step sodium profiles result in better plasma volume refilling in early dialysis, while linear dialysate sodium profiles have greater plasma volume in late dialysis, suggesting that dialysate sodium profiles may need to be individualized for optimal response. Sodium profiling could also result in sodium retention, and long-term studies are needed in the elderly before their widespread use is recommended. Use of newer modalities such as continuous monitoring of plasma volume with Crit Line, and determination and monitoring of body-fluid compartments with bioimpedance may further improve vascular stability in the elderly.
authors.affiliation: Kraftsow Division of Nephrology, Albert Einstein Medical Center, Philadelphia, PA 19141, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Raja
mesh_terms: D000368:Aged; D000375:Aging / Q000378:metabolism*; D015314:Dialysis Solutions / Q000627:therapeutic use; D006801:Humans; D007022:Hypotension / Q000209:etiology / Q000517:prevention & control; D007700:Kinetics; D006435:Renal Dialysis / Q000009:adverse effects; D012964:Sodium / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use
chemical_list: D015314:Dialysis Solutions; D012964:Sodium