What is the difference of bone growth in SHR and SD rats?
1. Both sexes of spontaneously hypertensive rats (SHR) and Sprague-Dawley (SD) rats were used in this study. 2. At 6, 12, 18, 24, 30, 36, 42, 48, 54 and 60 weeks old, tibia length (L), volume (V), dry weight (DW), bone mineral density (BMD) in tibia and serum biochemical parameters (Ca2+, Ca, iP, ALP, TRAP) were measured. 3. At the 18 and 48 weeks old, bone morphometry was performed (mineral apposition rate, trabecular bone volume and trabecular thickness). Serum PTH and osteocalcin level were determined in 18 week old rats. 4. The time course change of DW, L and V were almost the same as the trends of bodyweight in each group, namely, male SD had the highest value, female SD and male SHR showed the same value and the lowest figures were obtained in female SHR. 5. BMD of the middle area showed almost the same trends with the time course change of bodyweight. On the other hand, both sexes of SHR had lower BMD than that of SD in the proximal area. 6. Serum biochemical parameters showed the same trends in both sexes of SD and SHR except for ALP (a marker of bone formation) which was higher in male than in female rats. 7. Mineral apposition rate, trabecular bone volume and trabecular thickness were not different between the same sex of SD and SHR. 8. These findings suggest that trabecular bone in SHR had a lower mineral status than that of SD rats not only in the adult but also in the young. This alteration may due to the abnormal mineralization mechanisms.
Inoue
T
T
Pharma Research and Development Division, Hoechst Japan Ltd., Kawagoe-shi, Saitama.
Moriya
A
A
Goto
K
K
Tanaka
T
T
Inazu
M
M
D000375:Aging / Q000502:physiology; D000818:Animals; D001835:Body Weight / Q000502:physiology; D015519:Bone Density; D001846:Bone Development / Q000235:genetics / Q000502:physiology*; D001842:Bone and Bones / Q000033:anatomy & histology; D005260:Female; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D017207:Rats, Sprague-Dawley; D013752:Tetracycline / Q000494:pharmacology
D011500:Protein Synthesis Inhibitors; D013752:Tetracycline