title: Comparison of a lactate-versus acetate-based hemofiltration replacement fluid in patients with acute renal failure.
abstract: The objective of the study was to determine the impact of a lactate- and an acetate-based hemofiltration replacement fluid (HF) on the acid-base status in patients with acute renal failure (ARF) and continuous venovenous hemofiltration (CVVH). The prospective, cohort study was carried out in the intensive care unit of the Heinrich-Heine University Hospital, Düsseldorf, FRG. Subjects were 84 critically ill patients with ARF and CVVH. Fifty-two patients were subjected to lactate-based (group 1) and 32 to acetate-based hemofiltration (group 2). Thirty-eight patients had a septic, 46 a cardiovascular origin of the ARF. Creatinine, BUN, serum bicarbonate, arterial pH, lactate and APACHE II score were noted daily. Mean CVVH duration was 9.8 +/- 8.1 days; mortality was 65%. The groups did not differ with regard to the main clinical parameters. Lacate-based hemofiltration led to significantly higher serum bicarbonate and arterial pH values as compared to the acetate-based hemofiltration. Baseline serum bicarbonate values were 23.3 +/- 8.3 mmol/L in group 1 and 21.6 +/- 4.3 mmol/L in group 2 (NS); values at 48 h after initiating CVVH treatment were 25.7 +/- 3.8 mmol/L and 20.6 +/- 3.1 mmol/L, respectively (p < 0.001). Arterial pH prior to CVVH treatment was 7.36 +/- 0.1 in group 1 and 7.34 +/- 0.1 in group 2 (NS), and 7.43 +/- 0.07 versus 7.37 +/- 0.06 (p < 0.001) on day 2. These findings were maintained throughout therapy. While a lack of increase in serum bicarbonate and arterial pH was correlated to a poor prognosis in lactate-based hemofiltration, no such observation could be made in acetate-based hemofiltration. Septic patients did not differ in their acid-base status from nonseptic patients. Lactic acidosis occurred in 8 septic patients irrespective of the substitution fluid. All 8 patients died. There was a significant increase in HCO3 and arterial pH values in lactate-based as compared to acetate-based HF.
authors.affiliation: Department of Nephrology, Heinrich-Heine University, Düsseldorf, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Morgera
authors.forename: P
authors.initials: P
authors.lastname: Heering
authors.forename: T
authors.initials: T
authors.lastname: Szentandrasi
authors.forename: E
authors.initials: E
authors.lastname: Manassa
authors.forename: M
authors.initials: M
authors.lastname: Heintzen
authors.forename: R
authors.initials: R
authors.lastname: Willers
authors.forename: J
authors.initials: J
authors.lastname: Passlick-Deetjen
authors.forename: B
authors.initials: B
authors.lastname: Grabensee
mesh_terms: D018806:APACHE; D000085:Acetates / Q000009:adverse effects / Q000097:blood; D000136:Acid-Base Equilibrium; D000140:Acidosis, Lactic / Q000097:blood / Q000139:chemically induced / Q000401:mortality; D058186:Acute Kidney Injury / Q000097:blood / Q000401:mortality / Q000628:therapy*; D001639:Bicarbonates / Q000097:blood; D001806:Blood Urea Nitrogen; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D015314:Dialysis Solutions / Q000009:adverse effects; D005260:Female; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000009:adverse effects / Q000097:blood; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015996:Survival Rate
chemical_list: D000085:Acetates; D001639:Bicarbonates; D015314:Dialysis Solutions; D019344:Lactic Acid; D003404:Creatinine