title: Craniospinal dissemination of central neurocytoma. Report of two cases.
abstract: Central neurocytoma was first described in the literature in 1982 and has been noted to be a benign neuronal tumor usually located in the ventricular system. Of the more than 100 reported cases, only seven recurrences have been reported, all of which have been local. The authors report two cases of recurrent central neurocytoma that disseminated through the ventricular system with seeding to the spine, as evidenced by magnetic resonance images and positive cerebrospinal fluid cytology. The histological appearance of these two tumors was typical for the lesion and lacked evidence of malignant change. Central neurocytoma may not be as benign as previously thought, and the recognition of this more malignant behavior has implications for patient follow up and therapy.
authors.affiliation: Department of Neurosurgery, University of Texas, M. D. Anderson Cancer Center, Houston, USA.
authors.forename: D Y
authors.initials: DY
authors.lastname: Eng
authors.forename: F
authors.initials: F
authors.lastname: DeMonte
authors.forename: L
authors.initials: L
authors.lastname: Ginsberg
authors.forename: G N
authors.initials: GN
authors.lastname: Fuller
authors.forename: K
authors.initials: K
authors.lastname: Jaeckle
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002551:Cerebral Ventricle Neoplasms / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004388:Dura Mater / Q000473:pathology; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009366:Neoplasm Seeding; D009360:Neoplastic Cells, Circulating / Q000473:pathology; D018306:Neurocytoma / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D012688:Septum Pellucidum / Q000473:pathology; D013120:Spinal Cord Neoplasms / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D000972:Antineoplastic Agents, Phytogenic; D005047:Etoposide; D003520:Cyclophosphamide; D002945:Cisplatin