title: Parkinson's disease: an investigation of exercise capacity, respiratory function, and gait.
abstract: OBJECTIVE
  To evaluate the exercise capacity of subjects with mild to moderate Parkinson's disease and determine whether abnormalities in respiratory function and gait affect exercise capacity.
  
  
  METHODS
  Descriptive. Subjects were categorized according to exercise history, disease severity, and presence/absence of upper airway obstruction.
  
  
  METHODS
  Sixteen volunteers with mild to moderate idiopathic Parkinson's disease attended a university research laboratory.
  
  
  METHODS
  Subjects performed a maximum exercise test on a cycle ergometer, together with respiratory function tests and a walking test. Peak values for oxygen consumption and work rate were recorded for the maximum exercise test. Measures of respiratory function included spirometry, flow-volume loops, lung volumes, and mouth pressures. Velocity, stride length, and cadence were measured for preferred and fast speeds of walking. The values obtained on each of these tests were compared with published predicted age- and gender-matched normal values.
  
  
  RESULTS
  Peak oxygen consumptions and peak work loads achieved by subjects with Parkinson's disease were not significantly different from normal values, despite evidence of respiratory and gait abnormalities typical of Parkinson's disease. Exercise category was significantly correlated with percent predicted VO2peak (r = .64, p < .01), with sedentary subjects producing lower scores than exercising subjects. There was no significant correlation between disease severity and percent predicted VO2peak.
  
  
  CONCLUSIONS
  Despite their neurological deficit, individuals with mild to moderate Parkinson's disease have the potential to maintain normal exercise capacity with regular aerobic exercise.
authors.affiliation: School of Physiotherapy, Faculty of Health Sciences, University of Sydney, Lidcombe, NSW, Australia.
authors.forename: C G
authors.initials: CG
authors.lastname: Canning
authors.forename: J A
authors.initials: JA
authors.lastname: Alison
authors.forename: N E
authors.initials: NE
authors.lastname: Allen
authors.forename: H
authors.initials: H
authors.lastname: Groeller
mesh_terms: D000402:Airway Obstruction / Q000150:complications; D015444:Exercise; D005080:Exercise Test; D005260:Female; D005684:Gait; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology*; D012119:Respiration; D012129:Respiratory Function Tests; D012720:Severity of Illness Index