Resolution of CNS lesions following treatment of experimental allergic encephalomyelitis in macaques with monoclonal antibody to the CD18 leukocyte integrin.
Experimental allergic encephalomyelitis (EAE) in macaques is an acute inflammatory and demyelinating disease of the central nervous system (CNS) which has been studied extensively as a model of the human demyelinating disease multiple sclerosis (MS). The in vivo administration of monoclonal antibodies against CD18, the common beta-chain of a leukocyte integrin, at the onset of clinical disease, significantly prolonged the survival of nine of 11 macaques (82%) and in some cases completely reversed the clinical appearance of disease. Treatment with anti-CD18 mAbs dramatically reduced the extent of inflammation in brain lesions as determined by magnetic resonance imaging (MRI). These improvements confirm that anti-CD18 mAbs are powerful anti-inflammatory agents in vivo and suggest that such mAbs may provide effective treatment of both demyelinating and inflammatory CNS diseases in man.
Rose
L M
LM
Department of Pathology, University of Washington School of Medicine, Seattle 98195, USA.
Richards
T L
TL
Peterson
J
J
Petersen
R
R
Alvord
E C
EC
D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis / Q000276:immunology* / Q000627:therapeutic use*; D001921:Brain / Q000473:pathology; D018821:CD18 Antigens / Q000276:immunology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000097:blood / Q000175:diagnosis / Q000628:therapy*; D007958:Leukocyte Count; D008252:Macaca fascicularis; D008279:Magnetic Resonance Imaging; D008297:Male; D016019:Survival Analysis
D000911:Antibodies, Monoclonal; D018821:CD18 Antigens