title: [The effect of the live weight of rats on the intestinal in vitro absorption of nickel using everted intestinal sacs].
abstract: The influence of the live weight of the experimental animals on the Ni absorption was investigated in vitro with everted sacs from rats. Totally 75 male rats in the live weight range from 30 to 250 g were used. With increasing live weight the Ni uptake by the intestinal wall and the Ni transfer across the intestinal wall decreased significantly. Ni transfer was already significantly reduced by 45% when body weight increased from 30 to 60 g. For the animals with a live weight above 200 g Ni transfer reached only about 10% of the Ni transfer measured for the animals with 30 g live weight. The decline of the Ni uptake by the intestinal wall was only slightly in the live weight range from 30 to 150 g. Within the live weights higher than 190 g Ni uptake by the intestinal wall decreased significantly to about 25% compared to the animals with 30 g live weight.
authors.affiliation: Institut für Ernährungsphysiologie, Technischen Universität München in Freising-Weihenstephan, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Eidelsburger
authors.forename: M
authors.initials: M
authors.lastname: Kirchgessner
mesh_terms: D000818:Animals; D001835:Body Weight / Q000502:physiology*; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000502:physiology*; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D009532:Nickel / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009532:Nickel
vernacular_title: Zum Einfluss der Lebendmasse von Ratten auf die intestinale in vitro Absorption von Nickel mit evertierten Darmsäckchen.