Endothelium in hemostasis and thrombosis.
Endothelial cells synthesize and secrete PA and PAI, and thus provide anticoagulant and procoagulant regulatory mechanisms, respectively. Both plasminogen and plasminogen activators (t-PA and u-PA) bind to specific cellular receptors; assembly of components of the fibrinolytic system at the endothelial cell surface results in stimulation of fibrinolytic activity. Several mechanisms contribute to this stimulation, eg, enhanced plasminogen activation by t-PA or u-PA, enhanced conversion of scu-PA to tcu-PA, and impaired inhibition of plasmin by alpha2-antiplasmin or of PAs by PAIs. Thus, the endothelial cell surface serves as a focal point for plasmin generation.
Lijnen
H R
HR
Center for Molecular and Vascular Biology, K.U. Leuven, Belgium.
Collen
D
D
D004730:Endothelium, Vascular / Q000166:cytology / Q000502:physiology*; D005342:Fibrinolysis / Q000502:physiology; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology; D015394:Molecular Structure; D013927:Thrombosis / Q000503:physiopathology; D010959:Tissue Plasminogen Activator / Q000502:physiology*; D014568:Urokinase-Type Plasminogen Activator / Q000502:physiology*
D008562:Membrane Glycoproteins; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator