title: Life-threatening, recurrent anaphylaxis caused by allergy to gliadin and exercise.
abstract: BACKGROUND
  Exercise-induced urticaria or anaphylaxis is regarded as a distinct form of physical allergy. In some patients the symptoms occur only after ingestion of various food products in connection with exercise. We have come across patients with cereal dependent exercise-induced anaphylaxis.
  
  
  OBJECTIVE
  The purpose of the present study was to analyse the allergens in cereals responsible for the severe anaphylactic symptoms and to verify the test methods suitable for screening the patients with cereal dependent exercise-induced anaphylaxis.
  
  
  METHODS
  The patients underwent skin-prick tests (SPT) with common inhalant and food allergens as well as with various cereal extracts. IgE-immunoblotting was used to identify the allergenic fractions.
  
  
  RESULTS
  Five patients found positive in SPT with NaCl wheat suspension had IgE antibodies to wheat, rye, barley and oats, especially directed against the ethanolsoluble protein fractions in immunoblotting. No IgE antibodies were detected against other cereals. The patients had been unaware of any cereal allergy since anaphylaxis occurred only in association with exercise postprandially. The patients were directed to follow a gluten-free diet and have been free from symptoms, being able to continue their outdoor physical activities.
  
  
  CONCLUSIONS
  Wheat gliadin and the corresponding ethanol-soluble proteins of taxonomically closely related cereals were found to be the allergens in cereal-dependent exercise-induced anaphylaxis. Skin-prick testing with NaCl wheat suspension was a simple and practical test to screen patients with this kind of occult, possibly life-threatening, allergy to cereals.
authors.affiliation: Department of Dermatology, University Hospital of Helsinki, Finland.
authors.forename: E
authors.initials: E
authors.lastname: Varjonen
authors.forename: E
authors.initials: E
authors.lastname: Vainio
authors.forename: K
authors.initials: K
authors.lastname: Kalimo
mesh_terms: D000328:Adult; D000368:Aged; D000707:Anaphylaxis / Q000209:etiology* / Q000276:immunology / Q000401:mortality; D015444:Exercise; D017809:Fatal Outcome; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications* / Q000178:diet therapy; D005903:Gliadin / Q000009:adverse effects* / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011852:Radioallergosorbent Test; D012008:Recurrence; D012882:Skin Tests; D014581:Urticaria / Q000209:etiology
chemical_list: D005903:Gliadin