The effects of noribogaine and harmaline in rats trained with ibogaine as a discriminative stimulus.
In the present investigation, Fischer-344 rats were trained to discriminate 10.0 mg/kg of ibogaine from water using a pretreatment time of 60 minutes. Analysis of dose response data generated an ED50 of 4.6 mg/kg. The time course of the ibogaine (10.0 mg/kg) cue was also determined. The stimulus reached a maximum level of 94% ibogaine-appropriate responding at the 60-min pretreatment time. This was followed by a time-dependent decrease in ibogaine-appropriate responding. At a pretreatment time of 8 hrs only 6.4% drug-appropriate responding was observed. In substitution experiments, intermediate generalization was observed with a metabolite of ibogaine, 12-hydroxyibogamine [noribogaine] (71.6%) whereas complete generalization was seen with harmaline (83.5%).
Helsley
S
S
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo 14214-3000, USA.
Rabin
R A
RA
Winter
J C
JC
D000818:Animals; D004193:Discrimination Learning / Q000187:drug effects* / Q000502:physiology; D006213:Hallucinogens / Q000494:pharmacology; D006246:Harmaline / Q000494:pharmacology*; D006801:Humans; D007050:Ibogaine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D019966:Substance-Related Disorders / Q000188:drug therapy; D013997:Time Factors
D006213:Hallucinogens; D007050:Ibogaine; C094385:noribogaine; D006246:Harmaline