[Systemic and pulmonary hemodynamics in the course of substitute therapy with exosurf neonatal in newborn infants with respiratory distress syndrome].
The effect of double endotracheal administration of Exosurf Neonatal (Wellcome, Great Britain) in a dose of 5 ml/kg on the central and pulmonary hemodynamics, frequency of hemodynamically significant functioning arterial duct (FAD), and lung hemorrhages was studied by Doppler echocardiography in 25 newborns with the respiratory distress syndrome. The hemodynamic parameters were assessed before drug administration, directly and 2 hours after it, and at the age of 1, 2, and 3 days. An unreliable reduction of pulmonary vascular resistance and increase of volumic pulmonary blood flow were observed as soon as during the first minutes after administration of exosurf; this was not paralleled by a pathological increase of the left-right shunting of the blood through patent ductus arteriosus. During the three days that followed the postloading of the right ventricle reliably decreased and the pulmonary bloodflow, cardiac output, and systemic arterial pressure increased. If the traditional measures preventing the possible volumic overloading of the pulmonary circulation in the presence of patent ductus arteriosus were not neglected, administration of exosurf to newborns with the respiratory distress syndrome did not lead to an increase in the frequency of hemodynamically significant FAD and pulmonary hemorrhages.
Milenin
O B
OB
Efimov
M S
MS
D000328:Adult; D000367:Age Factors; D001034:Apgar Score; D004338:Drug Combinations; D004374:Ductus Arteriosus, Patent / Q000503:physiopathology; D005233:Fatty Alcohols / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000503:physiopathology; D008297:Male; D007744:Obstetric Labor Complications; D010767:Phosphorylcholine; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000627:therapeutic use*; D011247:Pregnancy; D011248:Pregnancy Complications; D011652:Pulmonary Circulation; D011663:Pulmonary Surfactants / Q000008:administration & dosage / Q000627:therapeutic use*; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D013997:Time Factors; D014655:Vascular Resistance
D004338:Drug Combinations; D005233:Fatty Alcohols; D011663:Pulmonary Surfactants; D010767:Phosphorylcholine; D011092:Polyethylene Glycols; C047049:dipalmitoylphosphatidylcholine, hexadecanol, tyloxapol drug combination
Sistemnaia i legochnaia gemodinamika na fone zamestitel'noĭ terapii sinteticheskikm surfaktantom "ekzosurf neonatal" u novorozhdennykh s respiratornym distress-sindromom.