title: Resolution of CNS lesions following treatment of experimental allergic encephalomyelitis in macaques with monoclonal antibody to the CD18 leukocyte integrin.
abstract: Experimental allergic encephalomyelitis (EAE) in macaques is an acute inflammatory and demyelinating disease of the central nervous system (CNS) which has been studied extensively as a model of the human demyelinating disease multiple sclerosis (MS). The in vivo administration of monoclonal antibodies against CD18, the common beta-chain of a leukocyte integrin, at the onset of clinical disease, significantly prolonged the survival of nine of 11 macaques (82%) and in some cases completely reversed the clinical appearance of disease. Treatment with anti-CD18 mAbs dramatically reduced the extent of inflammation in brain lesions as determined by magnetic resonance imaging (MRI). These improvements confirm that anti-CD18 mAbs are powerful anti-inflammatory agents in vivo and suggest that such mAbs may provide effective treatment of both demyelinating and inflammatory CNS diseases in man.
authors.affiliation: Department of Pathology, University of Washington School of Medicine, Seattle 98195, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Rose
authors.forename: T L
authors.initials: TL
authors.lastname: Richards
authors.forename: J
authors.initials: J
authors.lastname: Peterson
authors.forename: R
authors.initials: R
authors.lastname: Petersen
authors.forename: E C
authors.initials: EC
authors.lastname: Alvord
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis / Q000276:immunology* / Q000627:therapeutic use*; D001921:Brain / Q000473:pathology; D018821:CD18 Antigens / Q000276:immunology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000097:blood / Q000175:diagnosis / Q000628:therapy*; D007958:Leukocyte Count; D008252:Macaca fascicularis; D008279:Magnetic Resonance Imaging; D008297:Male; D016019:Survival Analysis
chemical_list: D000911:Antibodies, Monoclonal; D018821:CD18 Antigens