Function of the bone protein osteocalcin: definitive evidence.
Mice that lacked the genes for the bone protein osteocalcin were generated and were used to study the function of osteocalcin. These osteocalcin-deficient mutants had normal bones at birth but had increased bone density and thickness at 6 months. Their osteoblasts deposited more bone matrix than those of wild-type mice, though mineralization was not affected. Osteocalcin, therefore, was concluded to be a negative regulator of bone formation.
Wolf
G
G
Department of Nutritional Sciences, University of California, Berkeley 94720-3104, USA.
D000818:Animals; D051379:Mice; D015675:Osteocalcin / Q000502:physiology*
D015675:Osteocalcin