title: Hyperkeratosis of the nipple: report of two cases.
abstract: Hyperkeratosis of the nipple and areola is a rare condition; its characteristic properties are verrucous thickening and brownish discoloration of the nipples and areola. The nevoid form of the disease is extremely rare, usually seen in women in the second or third decade of life. The nipple is seldom affected alone. We report two cases of the nevoid form of hyperkeratosis of the nipple. In both female patients, lesions developed after puberty and were confined to both nipples alone. One of the patients' lesions became darker and more verrucous during pregnancy, making breast feeding impossible.
authors.affiliation: Department of Dermatology, Akdeniz University Medical Faculty, Antalya, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Alpsoy
authors.forename: E
authors.initials: E
authors.lastname: Yilmaz
authors.forename: A
authors.initials: A
authors.lastname: Aykol
mesh_terms: D000293:Adolescent; D000328:Adult; D001941:Breast Diseases / Q000188:drug therapy / Q000473:pathology; D001942:Breast Feeding; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000188:drug therapy / Q000473:pathology; D007641:Keratolytic Agents / Q000627:therapeutic use; D007642:Keratosis / Q000188:drug therapy / Q000473:pathology*; D009558:Nipples / Q000473:pathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000473:pathology; D014212:Tretinoin / Q000627:therapeutic use; D014860:Warts / Q000188:drug therapy / Q000473:pathology
chemical_list: D007641:Keratolytic Agents; D014212:Tretinoin