HLA class I antigens in Japanese patients with melanoma.
In this study, we analyzed the frequencies of human leukocyte antigen (HLA) class I alleles in 110 Japanese patients with melanoma using serological methods, and compared such frequencies with clinical parameters. As expected, frequencies of HLA allele distribution in patients with melanoma reflected the frequencies observed in the normal Japanese population. Because these are different from populations belonging to other races (e.g., white), it followed that the HLA allele distribution in melanoma patients varies among different races. This differences may have significant implications for T-cell-mediated, HLA-restricted therapeutic modalities. No significant associations between HLA and clinical parameters were noted in this study. This report may help design future clinical trials involving therapeutic approaches based on HLA-restricted mechanisms.
Kageshita
T
T
Department of Dermatology, Kumamoto University School of Medicine, Japan.
Naruse
T
T
Hirai
S
S
Horikoshi
T
T
Nakagawa
H
H
Tamaki
K
K
Hayashibe
K
K
Ichihashi
M
M
Nakayama
J
J
Hori
Y
Y
Ozawa
A
A
Miyahara
M
M
Ohkido
M
M
Inoko
H
H
Ono
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008545:Melanoma / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012878:Skin Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*
D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I