title: Enhancement of central noradrenaline release during development alters the packing density of neurons in the rat occipital cortex.
abstract: The effect of chronic yohimbine treatment early in life on packing density of neurons was evaluated in the occipital cortex of young rats. Yohimbine administration to pups between days 5 and 16 of postnatal life (2.5 mg/kg/day i.p.) resulted at 45 days of age in significantly higher neuronal density in layers II-V of the occipital cortex, the effect being more marked in the dorsal region than in the dorsolateral and lateral ones. Results suggest a relationship between enhanced central noradrenaline activity and altered development of the neuropil in the occipital cortex.
authors.affiliation: Unit of Neurophysiology and Biophysics, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile.
authors.forename: S
authors.initials: S
authors.lastname: Ruiz
authors.forename: V
authors.initials: V
authors.lastname: Fernández
authors.forename: J
authors.initials: J
authors.lastname: Belmar
authors.forename: A
authors.initials: A
authors.lastname: Hernández
authors.forename: H
authors.initials: H
authors.lastname: Pérez
authors.forename: M
authors.initials: M
authors.lastname: Sanhueza-Tsutsumi
authors.forename: S
authors.initials: S
authors.lastname: Alarcón
authors.forename: R
authors.initials: R
authors.lastname: Soto-Moyano
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D002452:Cell Count; D005260:Female; D008297:Male; D009474:Neurons / Q000166:cytology* / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism*; D009778:Occipital Lobe / Q000166:cytology* / Q000187:drug effects / Q000254:growth & development*; D051381:Rats; D017208:Rats, Wistar; D015016:Yohimbine / Q000494:pharmacology*
chemical_list: D000317:Adrenergic alpha-Antagonists; D015016:Yohimbine; D009638:Norepinephrine