The correlation between pharmacodynamics and pharmacokinetics: basics of pharmacokinetics--pharmacodynamics modeling.
This article gives an introduction to the combination of drug transports and drug action in a body system. With the law of mass action, the Emax model has been deduced as the basis of correlation between pharmacokinetics and pharmacodynamics.
Cawello
W
W
Schwarz Pharma AG, Monheim am Rhein, Germany.
Antonucci
T
T
D000818:Animals; D006801:Humans; D008954:Models, Biological; D010599:Pharmacokinetics; D010600:Pharmacology / Q000379:methods*; D011955:Receptors, Drug / Q000187:drug effects
D011955:Receptors, Drug