Oocyte and zygote ketoaldehyde utilisation.
Mouse oocytes and zygotes, when solubilised demonstrated that a range of ketoaldehydes could be utilised as substrates. Of the five ketoaldehydes investigated the overall substrate utilisation was hydroxypyruvate > glyoxylate > 2-ketobutyrate > pyruvate > glycolate. The utilisation of these ketoaldehydes during early development by LD-1 may provide a source of new metabolic substrates in addition to the potential control of aldehyde toxicity. It is proposed therefore that the LD-1 isoenzyme is responsible for ketoaldehyde utilisation prior to implantation thereby providing a source of alternative metabolic substrates for the developing embryo.
Legge
M
M
Department of Biochemistry, University of Otago, Dunedin, New Zealand.
D000818:Animals; D002087:Butyrates / Q000378:metabolism; D002264:Carboxylic Acids / Q000378:metabolism*; D006016:Glycolates / Q000378:metabolism; D006038:Glyoxylates / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D009865:Oocytes / Q000378:metabolism*; D011773:Pyruvates / Q000378:metabolism; D015053:Zygote / Q000378:metabolism*
D002087:Butyrates; D002264:Carboxylic Acids; D006016:Glycolates; D006038:Glyoxylates; D011773:Pyruvates; C031149:glycolic acid; C005087:alpha-ketobutyric acid; C012375:hydroxypyruvic acid; C031150:glyoxylic acid