Lipid mediators and protein kinase C for intracellular signalling.
1. The stimulation of a cell surface receptor initiates a degradation cascade of various membrane lipid constituents. 2. Many of their metabolites have potentials to induce, intensify and prolong the activation of protein kinase C that is needed for sustained cellular responses.
Nishizuka
Y
Y
Department of Biochemistry, Kobe University School of Medicine, Japan.
Nakamura
S
S
D000818:Animals; D007527:Isoenzymes / Q000378:metabolism; D008055:Lipids / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism; D011493:Protein Kinase C / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D007527:Isoenzymes; D008055:Lipids; D008565:Membrane Proteins; D011493:Protein Kinase C