High uptake of [2-11C]acetyl-L-carnitine into the brain: a PET study.
The brain uptake of acetylcarnitine was investigated in rhesus monkeys using different position labeled acetyl-L-carnitine and related molecules with 11C by positron emission tomography. The uptake values of radio-labeled acetylcarnitine into the brain were quite different depending on the labeling positions of 11C. That is, the uptake values of L-[methyl-11C]carnitine and acetyl-L-[methyl-11C]carnitine were almost the same and extremely low, while the uptake of [1-11C]-acetyl-L-carnitine was slightly higher. The uptake value of [2-11C]acetyl-L-carnitine was by far the highest among the 11C-labeled acetyl-L-carnitine and L-carnitine. The uptake of [2-11C]acetyl-L-carnitine into the brain was suppressed by the intravenous administration of glucose. These results suggest that endogenous serum acetyl-L-carnitine has some roles on conveying an acetyl moiety into the brain especially under an energy crisis, and that an unknown metabolic pathway of [2-11C]acetyl moiety might be rather active in the brain.
Kuratsune
H
H
Subfemtomole Biorecognition Project, Japan Science and Technology Corporation, Osaka, Japan. kuratune@bldon.med.osaka-u.ac.jp
Watanabe
Y
Y
Yamaguti
K
K
Jacobsson
G
G
Takahashi
M
M
Machii
T
T
Onoe
H
H
Onoe
K
K
Matsumura
K
K
Valind
S
S
Kitani
T
T
Långström
B
B
D000108:Acetylcarnitine / Q000493:pharmacokinetics*; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D002250:Carbon Radioisotopes; D002952:Citric Acid Cycle; D008253:Macaca mulatta; D014055:Tomography, Emission-Computed
D002250:Carbon Radioisotopes; D000108:Acetylcarnitine