title: Immunohistochemical study of hepatocellular carcinoma-specific aldehyde dehydrogenase.
abstract: Tumor-associated aldehyde dehydrogenase (ALDH) was reported in cases of human hepatocellular carcinoma and animal hepatoma models. This ALDH isozyme is similar to ALDH3 which exists in the stomach and lung; however, the biochemical and clinical significance of this unique ALDH isozyme have not been established. Human tumor-associated ALDH was purified, and polyclonal antibodies prepared. Using these antibodies, specific development of tumor-associated ALDH was confirmed by immunohistochemical techniques. It was found that about 50% of hepatocellular carcinomas reacted with the antibody. This unique ALDH isozyme may be a novel tumor marker of hepatocellular carcinoma.
authors.affiliation: Department of Internal Medicine, Kitasato University, School of Medicine, Sagamihara, Kanagawa, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Shibuya
authors.forename: A
authors.initials: A
authors.lastname: Takeuchi
authors.forename: H
authors.initials: H
authors.lastname: Shibata
authors.forename: K
authors.initials: K
authors.lastname: Saigenji
authors.forename: A
authors.initials: A
authors.lastname: Yoshida
mesh_terms: D000444:Aldehyde Dehydrogenase / Q000276:immunology*; D000906:Antibodies; D014408:Biomarkers, Tumor; D006528:Carcinoma, Hepatocellular / Q000276:immunology*; D046508:Culture Techniques; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000276:immunology*; D008113:Liver Neoplasms / Q000276:immunology*
chemical_list: D000906:Antibodies; D014408:Biomarkers, Tumor; D000444:Aldehyde Dehydrogenase