Effects of cisplatin on testicular functions in rats.
In adult male rats serum levels of FSH, LH and testosterone were determined following treatment with cisplatin [cis-diamminedichloroplatinum(II)] for 3 alternate days, in order to study the effects of cisplatin on pituitary-testicular axis and subsequent effects on spermatogenesis. The decreased levels of testosterone with elevated FSH and LH levels in CDDP-treated rats are indicative of intact pituitary-testicular axis. The quantitation of spermatogenesis by flow cytometric analysis revealed that various germ cell populations and kinetics of spermatogenesis remain unchanged in CDDP-treated rats. Thus, CDDP treatment has been shown to decrease testosterone production in the testis without affecting the functional status of spermatogenic compartment.
Malarvizhi
D
D
School of Life Sciences, Pondicherry University, India.
Mathur
P P
PP
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002945:Cisplatin / Q000633:toxicity*; D006728:Hormones / Q000097:blood; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000187:drug effects* / Q000503:physiopathology
D000970:Antineoplastic Agents; D006728:Hormones; D002945:Cisplatin