title: The mapping and visual ordering of the human syndecan-1 and N-myc genes near the telomeric region of chromosome 2p.
abstract: The chromosomal locations of the human and mouse syndecan genes have been shown to associate with the corresponding locations of members of the myc gene family, proto-oncogenes that code for transcription factors. Here, we demonstrate the precise localization and order of the human syndecan-1 and N-myc genes using fluorescence in situ hybridization techniques that provide different levels of resolution. By visualizing the actual centromere-telomere orientation of these two genes, the human syndecan-1 gene is localized to 2p23-24, just centromeric to the N-myc gene at 2p24.1.
authors.affiliation: Department of Clinical Medicine, University of Helsinki, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Kaukonen
authors.forename: L
authors.initials: L
authors.lastname: Alanen-Kurki
authors.forename: M
authors.initials: M
authors.lastname: Jalkanen
authors.forename: A
authors.initials: A
authors.lastname: Palotie
mesh_terms: D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D016259:Genes, myc; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008562:Membrane Glycoproteins / Q000235:genetics*; D011509:Proteoglycans / Q000235:genetics*; D013194:Staining and Labeling; D053668:Syndecan-1; D053667:Syndecans; D016615:Telomere
chemical_list: D008562:Membrane Glycoproteins; D011509:Proteoglycans; C508241:SDC1 protein, human; C508242:Sdc1 protein, mouse; D053668:Syndecan-1; D053667:Syndecans