[The antimicrobial activity of a new wound-healing compound ointment].
Drug composition containing polyethyleneoxide PEO-400 and PEO-1500 (8:2), antimicrobe agent-chloramphenical as well as new antiinflammatory mean of plant origin EOL in concentration of 5% has been created. Introduction of EOL to the composition of the drug under elaboration permitted decreasing chloramphenicol concentration 2-4 times as compared to concentrations used in contemporary ointments. This has lowered toxic and allergenic properties of the drug suggested for healing the infected wounds.
Iakushchenko
V A
VA
Biriukova
S V
SV
Dziuban
N F
NF
Piminov
A F
AF
Volianskiĭ
Iu L
IuL
Prokopenko
T S
TS
D000287:Administration, Topical; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000891:Anti-Infective Agents, Local / Q000494:pharmacology / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects; D002701:Chloramphenicol / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D005260:Female; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D008826:Microbial Sensitivity Tests; D009824:Ointments; D009930:Organic Chemicals; D010592:Pharmaceutic Aids / Q000494:pharmacology / Q000627:therapeutic use; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D011092:Polyethylene Glycols / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D009824:Ointments; D009930:Organic Chemicals; D010592:Pharmaceutic Aids; D010936:Plant Extracts; C088307:levosin; D011092:Polyethylene Glycols; D002701:Chloramphenicol
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