Neural reflex-mediated tracheal response during bronchoconstriction induced by ovalbumin antigen in guinea pigs.
1. The biphasic reflex tracheal response (constriction followed by dilatation) occurred during bronchoconstriction induced by inhalation of ovalbumin antigen (OA) in sensitized guinea pigs. 2. The reflex tracheal constriction was largely reduced by atropine, and the dilatation was inhibited by propranolol and N omega-nitro-L-arginine methyl ester (L-NAME). The noradrenaline, adrenaline, cyclic AMP, and cyclic GMP contents in the tracheal segment were significantly higher during reflex tracheal dilatation. 3. These findings suggest that cholinergic nerves may mediate reflex tracheal constriction and that adrenergic and NOergic nerves may mediate the ensuing reflex tracheal dilatation.
Takahashi
Y
Y
Department of Pharmacology, SS Pharmaceutical Co., Chiba, Japan.
Mizuno
H
H
Ohno
H
H
Misawa
M
M
D000485:Allergens; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D016084:Bronchoconstriction / Q000187:drug effects / Q000502:physiology*; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism; D006168:Guinea Pigs; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009412:Nerve Fibers / Q000187:drug effects; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D009638:Norepinephrine / Q000378:metabolism; D010047:Ovalbumin; D011433:Propranolol / Q000494:pharmacology; D012018:Reflex / Q000187:drug effects; D013779:Tetrodotoxin / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects / Q000294:innervation* / Q000378:metabolism; D014628:Vagotomy
D000485:Allergens; D009569:Nitric Oxide; D013779:Tetrodotoxin; D001285:Atropine; D010047:Ovalbumin; D011433:Propranolol; D000242:Cyclic AMP; D019001:Nitric Oxide Synthase; D006152:Cyclic GMP; D019331:NG-Nitroarginine Methyl Ester; D009638:Norepinephrine; D004837:Epinephrine