title: Bilateral recurrent laryngeal neurectomy as a model for the study of idiopathic canine laryngeal paralysis.
abstract: The purposes of this study were to develop an experimental model of canine laryngeal paralysis that mimicked the naturally occurring disease and to document the upper airway changes produced, both clinically and with pulmonary function testing. Ten dogs had bilateral recurrent laryngeal neurectomy performed and were recovered from anesthesia. Tidal breathing flow-volume loop analysis and upper airway resistance measurements were taken before and after the development of clinical laryngeal paralysis while dogs breathed room air and after the individual administration of 2 respiratory stimulants. Clinical signs of laryngeal paralysis developed 38 days (median) following denervation. Although some variations were present, tidal breathing flow-volume loop analyses on room air, following denervation, were similar to those reported in naturally occurring cases. Upper airway resistance increased following denervation and was significantly increased with both respiratory stimulants. We concluded that bilateral recurrent laryngeal neurectomy resulted in clinical signs and respiratory changes similar to those of idiopathic canine laryngeal paralysis.
authors.affiliation: Department of Veterinary Clinical Medicine, University of Illinois, College of Veterinary Medicine, Urbana 61802, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Greenfield
authors.forename: J C
authors.initials: JC
authors.lastname: Alsup
authors.forename: L L
authors.initials: LL
authors.lastname: Hungerford
authors.forename: B C
authors.initials: BC
authors.lastname: McKiernan
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000494:pharmacology; D004285:Dogs; D004315:Doxapram / Q000494:pharmacology; D007823:Laryngeal Nerves / Q000601:surgery*; D008297:Male; D011184:Postoperative Period; D012119:Respiration / Q000187:drug effects; D019141:Respiratory System Agents / Q000494:pharmacology; D014826:Vocal Cord Paralysis / Q000209:etiology / Q000503:physiopathology / Q000662:veterinary*
chemical_list: D019141:Respiratory System Agents; D002245:Carbon Dioxide; D004315:Doxapram