Conversion of cyclooxygenase inhibitors into hydroxythiazole 5-lipoxygenase inhibitors.
Representative examples of NSAID cyclooxygenase inhibitors such as naproxen, ibufenac, ibuprofen, and butibufen have been transformed into 5-lipoxygenase inhibitors by replacement of the carboxylic acid moiety with a 4-hydroxythiazole group.
Kerdesky
F A
FA
Abbott Laboratories, Abbott Park, IL 60064-3500, USA.
Brooks
C D
CD
Hulkower
K I
KI
Bouska
J B
JB
Bell
R L
RL
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry*; D006801:Humans; D007527:Isoenzymes / Q000032:analysis / Q000187:drug effects; D016859:Lipoxygenase Inhibitors / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases / Q000032:analysis / Q000187:drug effects; D011994:Recombinant Proteins / Q000032:analysis / Q000037:antagonists & inhibitors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D016859:Lipoxygenase Inhibitors; D008565:Membrane Proteins; D011994:Recombinant Proteins; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; C496511:PTGS1 protein, human; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases