title: Adrenomedullin: a new peptide involved in cardiorenal homeostasis?
abstract: Adrenomedullin (ADM) was originally discovered in human pheochromocytoma but is now known to be widely distributed in various organs including the kidney. ADM is a potent hypotensive peptide that increases renal blood flow and causes natriuresis and diuresis. While ADM may act in a paracrine manner, circulating levels are increased in hypertension, chronic renal failure and congestive heart failure. Current evidence suggests that ADM may play an important role in cardiorenal homeostasis.
authors.affiliation: Department of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406-0939, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Edwards
authors.forename: W
authors.initials: W
authors.lastname: Trizna
authors.forename: N
authors.initials: N
authors.lastname: Aiyar
mesh_terms: D053607:Adrenomedullin; D000595:Amino Acid Sequence; D002320:Cardiovascular Physiological Phenomena; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry / Q000502:physiology*; D012079:Renal Circulation / Q000502:physiology*; D014665:Vasodilator Agents / Q000378:metabolism*
chemical_list: D010455:Peptides; D014665:Vasodilator Agents; D053607:Adrenomedullin