Serum bupivacaine levels during laparoscopic sterilization using local anesthesia.
OBJECTIVE
To determine the serum levels of bupivacaine during laparoscopic sterilization when bupivacaine 0.5% without epinephrine is used as the sole local anesthetic agent.


METHODS
Case series.


METHODS
Regional medical center and primary teaching hospital of Ob/Gyn Department of the University of Tennessee, Memphis. PATIENTS; Thirty women undergoing laparoscopic sterilization with bupivacaine for local anesthesia.


METHODS
Venous serum bupivacaine levels were measured, with samples drawn at 45, 60, 90, and 120 minutes after injection in 25 patients. Five additional patients had sampling at 15 and 30 minutes as well as at the above times.


RESULTS
The highest concentration of bupivacaine was detected at 15 minutes. The mean concentrations at 15, 30, 45, 60, and 120 minutes were 0.86, 0.74, 0.31, 0.27, 0.23, and 0.22 microg/ml, respectively. This is well below the level of serious toxicity. Only four patients received 2.5 mg/kg or greater of bupivacaine. In these patients, mean serum levels were 1.1, 1.0, 0.28, 0.43, 0.9, and 0.29 microg/ml, respectively.


CONCLUSIONS
Serum bupivacaine levels during sterilization using bupivacaine 0.5% without epinephrine for local anesthesia are well below the threshold for serious toxicity.
Lipscomb
G H
GH
Department of Obstetrics and Gynecology, Room E-102, 853 Jefferson Avenue, Memphis, TN 38163, USA.
Summitt
R L
RL
McCord
M L
ML
Ling
F W
FW
D000772:Anesthesia, Local; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood*; D002045:Bupivacaine / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood*; D002849:Chromatography, Gas; D004837:Epinephrine; D005187:Fallopian Tubes; D005205:Fascia; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010535:Laparoscopy; D012404:Round Ligament of Uterus; D013246:Sterilization, Tubal; D013997:Time Factors; D014472:Umbilicus; D014662:Vasoconstrictor Agents; D014680:Veins
D000779:Anesthetics, Local; D014662:Vasoconstrictor Agents; D002045:Bupivacaine; D004837:Epinephrine