title: A pilot study of intravenous ondansetron for hyperemesis gravidarum.
abstract: OBJECTIVE
  We attempted to determine whether the antiemetic ondansetron would be more effective than promethazine in treating hyperemesis gravidarum.
  
  
  METHODS
  Patients with hyperemesis gravidarum who required hospital admission were randomized to receive either intravenous ondansetron (n = 15) or intravenous promethazine (n = 15) in a double-blind manner. Severity of disease was determined by electrolyte status, weight loss, ketonuria, and prior use of outpatient antiemetics. Outcome variables included degree of nausea, weight gain during treatment, days of hospitalization, and number of medication doses.
  
  
  RESULTS
  In this preliminary investigation ondansetron offered no advantage when compared with promethazine in the relief of nausea, weight gain, days of hospitalization (4.5 +/- 2.3 vs 4.5 +/- 1.5), and total doses of medication per hospitalization (2.1 +/- 1.2 vs 1.9 +/- 1.3).
  
  
  CONCLUSIONS
  This preliminary trial of ondansetron demonstrated no benefit over promethazine in patients hospitalized for hyperemesis gravidarum.
authors.affiliation: Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson 39216-4505, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Sullivan
authors.forename: C A
authors.initials: CA
authors.lastname: Johnson
authors.forename: H
authors.initials: H
authors.lastname: Roach
authors.forename: R W
authors.initials: RW
authors.lastname: Martin
authors.forename: D K
authors.initials: DK
authors.lastname: Stewart
authors.forename: J C
authors.initials: JC
authors.lastname: Morrison
mesh_terms: D000328:Adult; D000932:Antiemetics / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000188:drug therapy* / Q000503:physiopathology; D007275:Injections, Intravenous; D017294:Ondansetron / Q000627:therapeutic use*; D010865:Pilot Projects; D011247:Pregnancy; D011398:Promethazine / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000932:Antiemetics; D017294:Ondansetron; D011398:Promethazine