title: Leiomyomatosis peritonealis disseminata (LPD) with acute ascites induced by gonadotropin-releasing hormone (GnRH) agonist: a case report.
abstract: Leiomyomatosis peritonealis disseminata (LPD) is a rare disorder characterized by the development of numerous leiomyomata throughout the peritoneal cavity. We present a case of a 29-year-old woman who had LPD with acute ascites induced by a GnRH agonist (Supremon; buserelin acetate nasal solution 400 micrograms/per day). We found abdominal wall leiomyomata under the left rectus muscle. Because the disorder tended to recur with acute ascites in this patient, castration was performed to eliminate the hormonal stimulation of tumor growth. We suggest postponing hormone replacement therapy post-operatively for 6 months, and we recommend close follow-up to prevent tumor recurrence and hypoestrogenism.
authors.affiliation: Department of Obstetrics & Gynecology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, R.O.C.
authors.forename: C W
authors.initials: CW
authors.lastname: Tseng
authors.forename: C C
authors.initials: CC
authors.lastname: ChangChien
authors.forename: J W
authors.initials: JW
authors.lastname: Lin
authors.forename: T Y
authors.initials: TY
authors.lastname: Hsu
authors.forename: S Y
authors.initials: SY
authors.lastname: Chang
mesh_terms: D000208:Acute Disease; D000328:Adult; D001201:Ascites / Q000209:etiology*; D002064:Buserelin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D018231:Leiomyomatosis / Q000150:complications* / Q000628:therapy; D010534:Peritoneal Neoplasms / Q000150:complications* / Q000628:therapy
chemical_list: D002064:Buserelin