The involvement of sigma receptors in the choice reaction performance deficits induced by phencyclidine.
The present study investigated the effects of phencyclidine (PCP) on choice reaction in a 3-choice serial reaction time task for studying attentional function. PCP (3.2 mg/kg) significantly delayed choice reaction time and reduced choice accuracy. A novel sigma receptor antagonist N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]-ethylamine monohydrochloride (NE-100) at 3.2 mg/kg, and 1-(cyclopropylmethyl)-4-[2'-4"-fluorophenyl)-2'-oxoethyl]piperidin e HBr (DuP734) at 1.0-3.2 mg/kg, but not 4-[2'-(4"-cyanophenyl)-2'-oxoethyl]-1-(cyclopropylmethyl)pip eridine (XJ448), antagonized both the delayed choice reaction time and the decreased choice accuracy elicited by PCP administration. The antagonism induced by NE-100 was blocked by the sigma receptor agonist (+)-N-allylnormetazocine HCl [(+)-SKF10,047]. These findings indicated that PCP (3.2 mg/kg) significantly induced attention deficit in a 3-choice serial reaction time task, and that this process may be mediated by sigma receptors.
Jin
J
J
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Yamamoto
T
T
Watanabe
S
S
D000818:Animals; D000840:Anisoles / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000494:pharmacology; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology*; D008024:Ligands; D008297:Male; D010620:Phenazocine / Q000031:analogs & derivatives / Q000494:pharmacology; D010622:Phencyclidine / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology; D011437:Propylamines / Q000494:pharmacology; D011597:Psychomotor Performance / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects*; D017480:Receptors, sigma / Q000187:drug effects / Q000502:physiology*
D000840:Anisoles; D014150:Antipsychotic Agents; D018690:Excitatory Amino Acid Agonists; D008024:Ligands; D010880:Piperidines; D011437:Propylamines; D017480:Receptors, sigma; C083832:N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride; C012134:SK&F 10047; C078773:DuP 734; D010620:Phenazocine; D010622:Phencyclidine