Role of dopamine D1- and NMDA receptors in regulating neurotensin release in the striatum and nucleus accumbens.
Stimulation of dopamine D1-receptors by SKF 82958 increased extracellular neurotensin (NT) levels in the striatum and nucleus accumbens as measured by in vivo microdialysis while blockade of D1-receptors had no effect. Antagonism of NMDA receptors with MK 801 completely prevented the increased NT release induced by D1-stimulation in both structures. Tissue content of striatal NT anterior and posterior to the microdialysis probe was oppositely altered by D1-stimulation: increases were observed in the anterior striatum with decreased NT levels in the posterior striatum.
Wagstaff
J D
JD
NIMH, Laboratory of Neurophysiology, National Institute of Health, Bethesda, MD, USA.
Gibb
J W
JW
Hanson
G R
GR
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D016291:Dizocilpine Maleate / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D008297:Male; D017551:Microdialysis; D009496:Neurotensin / Q000378:metabolism*; D009714:Nucleus Accumbens / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000502:physiology*
D018691:Excitatory Amino Acid Antagonists; D017447:Receptors, Dopamine D1; D016194:Receptors, N-Methyl-D-Aspartate; D009496:Neurotensin; D016291:Dizocilpine Maleate