[Changes in the activation markers of blood coagulation and fibrinolysis in the neonatal period].
BACKGROUND
Activation markers of the clotting and fibrinolytic systems are elevated immediately after birth and decline to near adult levels during the first 24 hours of life. The aims of this study were to investigate, whether the activation of both clotting and fibrinolysis is dependent on the mode of delivery, and to measure activation markers in newborns with infection beyond the first days of life.


METHODS
We have studied activation markers thrombin-antithrombin III complex, prothrombin fragment 1 + 2, D-dimer and plasmin-antiplasmin complex by use of commercially available ELISA techniques in 20 newborns after elective Cesarean sections because of previous sections, in 20 newborns after Cesarean sections and a trial of labor with uterine contractions over a period of > 20 hours and in 20 newborns (34.-41. gestational week) aged 10-25 days with infection. 20 healthy adults served as controls.


RESULTS
A significant elevation of all activation markers was observed both in the newborns after Cesarean sections and in the 10-25 days old children with infection. There were no differences among newborns after elective sections compared to newborns after section and a trial of labor with uterine contractions over a period of > 20 hours.


CONCLUSIONS
The clotting and fibrinolytic systems reveal increased activation immediately after delivery, but uterine contractions over a period of > 20 hours seem not to make a difference. During infection, the activation markers of the hemostatic system in newborns aged 10-25 days behaves similarly to the mature adult system.
Ries
M
M
Klinik mit Poliklinik für Kinder und Jugendliche, Universität Erlangen-Nürnberg.
Klinge
J
J
Rauch
R
R
Zenker
M
M
Aydin
I
I
Harms
D
D
D000328:Adult; D000367:Age Factors; D000990:Antithrombin III / Q000032:analysis*; D002585:Cesarean Section; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D005341:Fibrinolysin / Q000032:analysis*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood*; D008297:Male; D010446:Peptide Fragments / Q000032:analysis*; D010447:Peptide Hydrolases / Q000032:analysis*; D011247:Pregnancy; D011516:Prothrombin / Q000032:analysis*; D012016:Reference Values; D018805:Sepsis / Q000097:blood* / Q000175:diagnosis; D014219:Trial of Labor; D000979:alpha-2-Antiplasmin / Q000032:analysis*
D005338:Fibrin Fibrinogen Degradation Products; D010446:Peptide Fragments; D000979:alpha-2-Antiplasmin; C046193:antithrombin III-protease complex; C036309:fibrin fragment D; C045879:prothrombin fragment 1.2; D000990:Antithrombin III; D011516:Prothrombin; D010447:Peptide Hydrolases; D005341:Fibrinolysin
Veränderungen der Aktivierungsmarker der Gerinnung und Fibrinolyse im Neugeborenenalter.