Effects of fructose-1,6-diphosphate on the activity of rat liver nitric oxide synthase in vitro.
Fructose-1,6-diphosphate (FDP) was found to cause significant stimulation of nitric oxide synthase (NOS) in rat liver homogenates in vitro. This effect was more pronounced for the inducible isoform than its constitutive counterpart. Furthermore, FDP restored rat liver inducible NOS levels following their depletion by carbon tetrachloride (CCl4). This finding may have further practical implications in hepatoprotection from various noxious chemical and biological agents.
Mihas
A A
AA
Veterans Affairs Medical Center, University of Mississippi School of Medicine, Jackson 39216, USA.
Maliakkal
R J
RJ
Mihas
T A
TA
Kanji
V K
VK
Markov
A K
AK
D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology; D004790:Enzyme Induction; D005635:Fructosediphosphates / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D019001:Nitric Oxide Synthase / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley
D005635:Fructosediphosphates; D002251:Carbon Tetrachloride; D019001:Nitric Oxide Synthase; C029063:fructose-1,6-diphosphate