[The effect of unilateral destruction of the head of the caudate nucleus with kainic acid on the structure of the wakefulness-sleep cycle and the EEG in rats].
The wakefulness-sleep cycle characteristics changes in Wistar line rats after unilateral lesions of the neuronal elements of the caudate nucleus head with kainic acid (at sparing the conducting ways going through this structure) were studied. It was shown that in 4 days after acid injection the share of the active wakefulness and light slow-wave sleep is significantly increased, whereas the percentage of the passive wakefulness, deep slow-wave stage, and paradoxal sleep (up to 80%) is reduced. The wakefulness-sleep cycle in rats is completely normalized on the 7th day after injection. The obtained data allow to consider the caudate nucleus as a modulator for wakefulness-sleep cycle, that is the structure involved in the motive activity regulation.
Vataev
S I
SI
Dem'ianenko
G P
GP
Titkov
E S
ES
Oganesian
G A
GA
D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D004569:Electroencephalography / Q000187:drug effects*; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology*; D005260:Female; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D010507:Periodicity; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects* / Q000502:physiology
D018690:Excitatory Amino Acid Agonists; D007608:Kainic Acid
Vliianie odnostoronnego razrusheniia golovki khvostatogo iadra kainovoĭ kisloty na strukturu tsikla bodrstvovanie--son i EEG u krys.