Novel polymeric solid-phase extraction material for complex biological matrices. Portable and disposable artificial kidney.
The replacement of conventional hemodialysis treatment for a patient with malfunctioning kidneys by providing him/her with a portable and disposable "artificial kidney" which is connected to implanted artery and veneous cannulas on a patient's wrist is discussed. During a continuous flow of blood, plasma diffuses through a plasmapheretic membrane, passes through a bed of plasmacompatible sorbent Styrosorb, and arrives at an ultrafiltration membrane. Vacuum-operated ultrafiltration removes excess water together with dissolved urea and other small molecules, and Stryosorb removes medium-sized toxic substances. The hemocompatibility of the sorbent is improved by chemical modification of the surface.
Davankov
V A
VA
Institute of Organo-Element Compounds, Russian Academy of Sciences, Moscow, Russia.
Pavlova
L A
LA
Tsyurupa
M P
MP
Tur
D R
DR
D001672:Biocompatible Materials; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D007688:Kidneys, Artificial; D011137:Polystyrenes / Q000627:therapeutic use*; D006435:Renal Dialysis; D014462:Ultrafiltration
D001672:Biocompatible Materials; D011137:Polystyrenes