title: The gene for Pendred syndrome is located between D7S501 and D7S692 in a 1.7-cM region on chromosome 7q.
abstract: Pendred syndrome is an autosomal recessive disorder characterized by goiter and congenital deafness. The primary defect is not yet known, although the gene causing Pendred syndrome has been localized very recently on chromosome 7q, a region that also contains a gene responsible for nonsyndromal hearing loss (DFNB4). We confirmed linkage to this chromosome 7 region in five Pendred families originating from different ethnic groups, with a highest cumulative lod score of 8.26 for marker D7S501. In combination with previous reports, our results define a candidate region for the Pendred gene of 1.7 cM flanked by markers D7S501 and D7S692.
authors.affiliation: Department of Medical Genetics, University of Antwerp-UIA, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Coucke
authors.forename: G
authors.initials: G
authors.lastname: Van Camp
authors.forename: O
authors.initials: O
authors.lastname: Demirhan
authors.forename: Y
authors.initials: Y
authors.lastname: Kabakkaya
authors.forename: W
authors.initials: W
authors.lastname: Balemans
authors.forename: P
authors.initials: P
authors.lastname: Van Hauwe
authors.forename: T
authors.initials: T
authors.lastname: Van Agtmael
authors.forename: R J
authors.initials: RJ
authors.lastname: Smith
authors.forename: A
authors.initials: A
authors.lastname: Parving
authors.forename: C H
authors.initials: CH
authors.lastname: Bolder
authors.forename: C W
authors.initials: CW
authors.lastname: Cremers
authors.forename: P J
authors.initials: PJ
authors.lastname: Willems
mesh_terms: D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006042:Goiter / Q000151:congenital / Q000235:genetics*; D006239:Haplotypes; D006319:Hearing Loss, Sensorineural / Q000151:congenital / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree; D013577:Syndrome
chemical_list: D005819:Genetic Markers