title: Lack of effect of hepatocyte growth factor on bone marrow suppression induced by total body irradiation in the rat.
abstract: We examined the role of hepatocyte growth factor (HGF) on the bone marrow suppression by irradiation, by analyzing peripheral blood counts 2 weeks after 7 Gy of total body irradiation in rats. The rats underwent two weeks of continuous intraperitoneal human recombinant HGF injection (50 mg/day) from one day before irradiation using an Alzet osmotic pump. Red blood cell, white blood cell, and platelet counts did not increase with response to administration of HGF. Thus HGF does not show protection against myelosuppression caused by total body irradiation.
authors.affiliation: Department of Radiation Oncology, Osaka University Medical School, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yamazaki
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: J T
authors.initials: JT
authors.lastname: Tang
authors.forename: T
authors.initials: T
authors.lastname: Nose
authors.forename: M
authors.initials: M
authors.lastname: Koizumi
authors.forename: E
authors.initials: E
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Teshima
authors.forename: S
authors.initials: S
authors.lastname: Ozeki
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Inoue
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects*; D017228:Hepatocyte Growth Factor / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000494:pharmacology; D014916:Whole-Body Irradiation
chemical_list: D011994:Recombinant Proteins; D017228:Hepatocyte Growth Factor