Ester-type cephalotaxus alkaloids from Cephalotaxus harringtonia var. drupacea.
Three alkaloids, neoharringtonine, homoneoharringtonine and 3'S-hydroxyneoharringtonine, were isolated from the leaves and stems of Cephalotaxus harringtonia var. drupacea. Their structures were established by spectroscopic methods, including two-dimensional NMR and CD spectra, and their antileukaemic activity was evaluated using P-388 leukaemia cells.
Takano
I
I
Tokyo Metropolitan Research Laboratory of Public Health, Japan.
Yasuda
I
I
Nishijima
M
M
Yanagi
Y
Y
Takeya
K
K
Itokawa
H
H
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D002942:Circular Dichroism; D007941:Leukemia P388 / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010944:Plants / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014407:Tumor Cells, Cultured
D000470:Alkaloids