title: Age and gender differences in hepatic ascorbic acid concentrations and NADPH-dehydroascorbic acid reductase activity.
abstract: Ascorbic acid content decreased with age in livers of male rats but not in those of female rats. The influence of aging on the regeneration of ascorbic acid from dehydroascorbic acid was investigated as a possible cause of declining ascorbate concentrations. The results demonstrate that hepatic NADPH-dehydroascorbic acid reductase activity is unaffected by aging.
authors.affiliation: University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA.
authors.forename: L E
authors.initials: LE
authors.lastname: Rikans
authors.forename: T R
authors.initials: TR
authors.lastname: Lopez
authors.forename: K R
authors.initials: KR
authors.lastname: Hornbrook
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism*; D005260:Female; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D012727:Sex Characteristics
chemical_list: D009247:NADH, NADPH Oxidoreductases; C023927:monodehydroascorbate reductase (NADH); D001205:Ascorbic Acid