[Absorption of various actinomycins by Staphylococcus aureus cells].
The absorption of actinomycin D by the cell suspension of Staphylococcus aureus via diffusion linearly depended on the antibiotic concentration in the suspension within the ranges of 2 to 15 micrograms/ml. The absorption of active actinomycins C2, C3 and Au6 was the same as that of actinomycin D. The Staphylococcus intact membranes limited the inlet of the actinomycins to the cells since the membranotropic substances such as gramicidin S and its derivatives and thyrocidin increased their absorption by 30-70 per cent. The absorption of a low active actinomycin D0 and inactive actinomycinic acid even after the exposure to the membranotropic substances was not detectable. These compounds did not form any complexes with DNA. The level of the absorption of the actinomycins by the cells was likely defined by their ability to complex with DNA.
Polin
A N
AN
Bulgakova
V G
VG
Orlova
T I
TI
Grushina
V A
VA
D000042:Absorption; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004269:DNA, Bacterial / Q000737:chemistry; D003609:Dactinomycin / Q000737:chemistry / Q000493:pharmacokinetics*; D006096:Gramicidin / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000378:metabolism*; D013696:Temperature
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D006096:Gramicidin; D003609:Dactinomycin
Pogloshchenie kletkami Staphylococcus aureus razlichnykh aktinomitsinov.