Long- and short-term effects of transmyocardial laser revascularization in acute myocardial ischemia.
OBJECTIVE
This study examined the effect of transmyocardial laser revascularization (TMLR) on infarct size and global and regional left ventricular (LV) function.


METHODS
Acute ischemia was induced in 24 dogs by ligating the left anterior descending artery. TMLR was done through a left thoracotomy in 12 dogs. The 12 control dogs had ligation only. Global and regional LV function were measured before ligation, then at 6 hours or 3 months after ligation. We calculated the volumetric ratio of damaged myocardium to myocardium at risk (Vd/Vr).


RESULTS
At 6 hours, global compensation despite regional dyskinesia was universal; Vd/Vr was the same in control and TMLR dogs. At 3 months, global function during stress was significantly higher in TMLR dogs than in control dogs (P < .05); regional contractions were synergic only in TMLR dogs; mean Vd/Vr was significantly lower in TMLR dogs.


CONCLUSIONS
TMLR limits infarct expansion and improves long-term global and regional function after acute ischemia.
Kadipasaoglu
K A
KA
Cardiovascular Research Laboratory, Texas Heart Institute, Houston 77030, USA.
Pehlivanoglu
S
S
Conger
J L
JL
Sasaki
E
E
de Villalobos
D H
DH
Cloy
M
M
Piluiko
V
V
Clubb
F J
FJ
Cooley
D A
DA
Frazier
O H
OH
D000818:Animals; D003326:Coronary Circulation; D004285:Dogs; D053685:Laser Therapy; D017202:Myocardial Ischemia / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D009204:Myocardial Revascularization / Q000379:methods; D009206:Myocardium / Q000473:pathology; D016277:Ventricular Function, Left