Naloxone attenuates serum corticosterone and augments serum glucose concentrations in broilers stimulated with adrenocorticotropin.
The effects of exogenous naloxone and adrenocorticotropin (ACTH) on circulating concentrations of corticosterone and glucose in broilers were determined. Birds were injected i.m. at 0 and 2 h with either saline or naloxone, then i.v. at 2.5 h with either saline or ACTH. Control birds received saline at each injection. Blood samples were taken before the experiment started (0 min) and 30, 60, and 90 min after the last injection. Intramuscular injections of naloxone significantly reduced subsequent ACTH-stimulated increases in serum corticosterone; however, when followed by saline, naloxone elevated corticosterone by 90 min after the final injection of saline. Glucose levels were significantly elevated at 60 min in birds receiving ACTH i.v., but remained elevated through 90 min in birds pretreated with naloxone. Naloxone pretreatment attenuated serum corticosterone but augmented serum glucose concentrations in ACTH-stimulated broilers.
Peebles
E D
ED
Poultry Science Department, Department Mississippi State University, Mississippi 39762, USA.
Pond
A L
AL
Thompson
J R
JR
McDaniel
C D
CD
Cox
N M
NM
Latour
M A
MA
D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis* / Q000378:metabolism; D002645:Chickens / Q000097:blood*; D003345:Corticosterone / Q000097:blood*; D004347:Drug Interactions; D007275:Injections, Intravenous; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D011863:Radioimmunoassay / Q000379:methods / Q000662:veterinary; D011897:Random Allocation; D013997:Time Factors
D001786:Blood Glucose; D009292:Narcotic Antagonists; D009270:Naloxone; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone