Language processing in aphasia: changes in lateralization patterns during recovery reflect cerebral plasticity in adults.
During single word processing the negative cortical DC-potential reveals a left frontal preponderance in normal right-handers as well as in patients with a history of transient aphasia. Lateralization of DC-negativity therefore provides a reliable and robust method for the assessment of language dominance. In 11 stroke patients with permanent aphasia this physiological pattern changed to bilateral activation reflecting an additional right-hemispheric involvement in compensatory mechanisms in aphasia. Along with complete clinical recovery the classical aphasic syndromes revealed specific differences in changes of their lateralization patterns. In Broca's aphasia the initial right-hemispheric preponderance changed to a left frontal lateralization while in Wernicke's aphasia a presumably permanent shift towards the right hemisphere occurred. Differences in lateralization patterns might reflect different mechanisms of recovery such as the initial disinhibition of homologous areas contralaterally and subsequent collateral sprouting and synaptic modulation. The assessment of changes in lateralization of the cortical DC-potential during language tasks in a non-invasive, safe method with excellent time resolution that might provide further insights in the neural basis of recovery from aphasia.
Thomas
C
C
Department of Neurology, University of Tübingen, Germany.
Altenmüller
E
E
Marckmann
G
G
Kahrs
J
J
Dichgans
J
J
D000200:Action Potentials; D000328:Adult; D000368:Aged; D001037:Aphasia / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009473:Neuronal Plasticity; D013569:Synapses / Q000648:ultrastructure