title: Unaltered monocyte function in patients with major depression before and after three months of antidepressive therapy.
abstract: Monocyte phenotypes and functions were studied in 22 patients with major depression, and compared with those of 22 matched healthy controls. Immune measures were performed before and after dexamethasone suppression, and after 4 and 12 weeks of moclobemide therapy in patients. Seven patients terminated after 4 weeks because of treatment failure; 11 out of 15 patients responded to therapy after 12 weeks. Monocyte human leukocyte antigen class II and CD14 antigen expression, tumor necrosis factor production, and plasma interferon-gamma and neopterin did not differ in patients before treatment and controls. The reaction to dexamethasone was also similar in patients and controls. Neither antidepressive treatment per se nor the clinical response to it affected any immunological parameter. In conclusion, corticosteroid-controlled monocyte functions were similar in untreated and treated depressed patients and in controls, and unrelated to the clinical course of the disease.
authors.affiliation: Department of Research, University Hospital, Basel, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Landmann
authors.forename: B
authors.initials: B
authors.lastname: Schaub
authors.forename: S
authors.initials: S
authors.lastname: Link
authors.forename: H R
authors.initials: HR
authors.lastname: Wacker
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001549:Benzamides / Q000627:therapeutic use; D002491:Central Nervous System Agents / Q000009:adverse effects; D016207:Cytokines / Q000096:biosynthesis; D003866:Depressive Disorder / Q000188:drug therapy* / Q000276:immunology* / Q000523:psychology; D003907:Dexamethasone / Q000009:adverse effects; D005260:Female; D005434:Flow Cytometry; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology; D018950:Lipopolysaccharide Receptors / Q000276:immunology; D008297:Male; D008875:Middle Aged; D020912:Moclobemide; D009000:Monocytes / Q000187:drug effects / Q000276:immunology*; D011569:Psychiatric Status Rating Scales
chemical_list: D000928:Antidepressive Agents; D001549:Benzamides; D002491:Central Nervous System Agents; D016207:Cytokines; D000949:Histocompatibility Antigens Class II; D018950:Lipopolysaccharide Receptors; D003907:Dexamethasone; D007371:Interferon-gamma; D020912:Moclobemide