Brasiliquinones A, B and C, new benz[alpha]anthraquinone antibiotics from Nocardia brasiliensis. I. Producing strain, isolation and biological activities of the antibiotics.
New benz[alpha]anthraquinone antibiotics (brasiliquinones A, B and C) with an ethyl group at C-3 were isolated. The producer was identified as Nocardia brasiliensis. The antibiotics were active against Gram-positive bacteria including Mycobacterium sp., but not active against Gram-negative bacteria or fungi. They were also active against multiple drug-resistant P388/ADR tumor cells.
Nemoto
A
A
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
Tanaka
Y
Y
Karasaki
Y
Y
Komaki
H
H
Yazawa
K
K
Mikami
Y
Y
Tojo
T
T
Kadowaki
K
K
Tsuda
M
M
Kobayashi
J
J
D000818:Animals; D000880:Anthraquinones / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D051379:Mice; D009615:Nocardia / Q000145:classification / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D000880:Anthraquinones; D000900:Anti-Bacterial Agents; C104992:brasiliquinone A; C104993:brasiliquinone B; C104994:brasiliquinone C