title: Benign and malignant portal vein thrombosis: differentiation by CT characteristics.
abstract: OBJECTIVE
  The purpose of this study was to determine if unique characteristics revealed by CT can allow radiologists to reliably distinguish benign from malignant portal vein thrombus (PVT) in patients with cirrhosis.
  
  
  METHODS
  CT examinations of 58 patients with cirrhosis and PVT were retrospectively reviewed. Images were assessed for location, extent, enhancement, neovascularity, and maximal diameter of PVT. The type of PVT was proven histologically in 42 patients and clinically in the remaining 16 patients. Using different threshold PVT diameters or the presence of PVT neovascularity, we calculated the sensitivity and specificity of CT for revealing malignant PVT.
  
  
  RESULTS
  Forty-seven patients had malignant and 11 patients had benign PVT. CT scans of patients with malignant PVT showed direct extension of hepatocellular carcinoma into the portal vein in 15 patients. In 29 patients with malignant PVT, CT scans showed PVT adjacent to tumor; CT scans showed tumor PVT remote from hepatocellular carcinoma in the remaining three patients with malignant PVT. The mean diameters of malignant and benign portal vein thrombi were significantly different (23.4 mm versus 16 mm; p = .0001). CT scans of 83% (39/47) of patients with malignant PVT and 18% (2/11) of patients with benign PVT showed generalized enhancement. Neovascularity was seen on CT scans in 43% (20/47) of patients with malignant PVT and in no patient with benign PVT. Identification of a main PVT diameter greater than or equal to 23 mm or PVT neovascularity resulted in a sensitivity and specificity for the CT characterization of malignant PVT of 86% and 100%, respectively.
  
  
  CONCLUSIONS
  Malignant and benign thrombi can often be differentiated by radiologists on the basis of CT imaging characteristics.
authors.affiliation: Department of Radiology, University of Pittsburgh Medical Center, PA 15213, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Tublin
authors.forename: G D
authors.initials: GD
authors.lastname: Dodd
authors.forename: R L
authors.initials: RL
authors.lastname: Baron
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000150:complications*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008113:Liver Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011169:Portal Vein / Q000000981:diagnostic imaging*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013927:Thrombosis / Q000000981:diagnostic imaging* / Q000209:etiology; D014057:Tomography, X-Ray Computed