Respective role of TNF receptors in the development of experimental cerebral malaria.
The respective role of the two receptors of TNF in experimental cerebral malaria (CM) was investigated. During CM, a significant upregulation of TNF-receptor 2 (TNFR2), but not of TNFR1, was found in brain microvessels of susceptible, but not resistant mice. Mice genetically deficient for TNFR2 (Tnfr2null) were significantly protected from CM, while TNFR1-deficient (Tfnr1null) mice were as susceptible as wild-type mice. The protection of Tnfr2null mice could be explained by their absence of ICAM-1 upregulation and leukocyte sequestration, known to occur in brain microvessels of CM-susceptible animals.
Lucas
R
R
Dept. of Anaesthesiology, Pharmacology and Surgical Intensive Care, University Medical Center, Geneva, Switzerland.
Lou
J N
JN
Juillard
P
P
Moore
M
M
Bluethmann
H
H
Grau
G E
GE
D000818:Animals; D001921:Brain / Q000098:blood supply / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D016779:Malaria, Cerebral / Q000209:etiology* / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008833:Microcirculation / Q000276:immunology / Q000378:metabolism; D010963:Plasmodium falciparum; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology*; D015854:Up-Regulation / Q000276:immunology
D018124:Receptors, Tumor Necrosis Factor