title: Hypercalcaemia in osteogenesis imperfecta treated with pamidronate.
abstract: The response to the bisphosphonate, pamidronate, is reported in a child with osteogenesis imperfecta who had recurrent symptomatic hypercalcaemia after immobilisation following fractures. Oral clodronate was effective in the prevention of immobilisation hypercalcaemia in the same child. The bisphosphonates may have other roles in osteogenesis imperfecta by decreasing bone turnover.
authors.affiliation: Department of Paediatrics, York District Hospital.
authors.forename: C J
authors.initials: CJ
authors.lastname: Williams
authors.forename: R A
authors.initials: RA
authors.lastname: Smith
authors.forename: R J
authors.initials: RJ
authors.lastname: Ball
authors.forename: H
authors.initials: H
authors.lastname: Wilkinson
mesh_terms: D000293:Adolescent; D004164:Diphosphonates / Q000627:therapeutic use*; D005598:Fractures, Spontaneous / Q000150:complications; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D010013:Osteogenesis Imperfecta / Q000150:complications*; D000077268:Pamidronate; D012008:Recurrence
chemical_list: D004164:Diphosphonates; D000077268:Pamidronate