title: Aminoacyl-tRNA synthesis: divergent routes to a common goal.
abstract: Aminoacyl-tRNAs are key components in protein synthesis. They are formed directly by correct acylation of tRNA (by aminoacyl-tRNA synthetases) or indirectly by tRNA-dependent transformation of misacylated tRNAs. The accuracy of aminoacyl-tRNA synthesis is enhanced by a number of further protein-RNA or protein-protein interactions, some of which are restricted to Archaea, and might reflect adaptation mechanisms to diverse conditions.
authors.affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520-8114, USA.
authors.forename: M
authors.initials: M
authors.lastname: Ibba
authors.forename: A W
authors.initials: AW
authors.lastname: Curnow
authors.forename: D
authors.initials: D
authors.lastname: Söll
mesh_terms: D000604:Amino Acyl-tRNA Synthetases / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D012346:RNA, Transfer, Amino Acyl / Q000096:biosynthesis*
chemical_list: D012346:RNA, Transfer, Amino Acyl; D000604:Amino Acyl-tRNA Synthetases