Erythropoietin is present in the cerebrospinal fluid of neonates.
Erythropoietin (Epo) was measured by enzyme-linked immunosorbent assay in 80 cerebrospinal fluid (CSF) samples to determine whether Epo is present in the CSF of infants, CSF Epo concentrations correlate with age, and CSF Epo concentrations correlate with Epo therapy. Epo was present in the CSF of normal neonates. CSF Epo concentrations correlated negatively with increasing age. Recombinant Epo therapy did not affect CSF Epo concentrations, although values ranged somewhat higher in this group.
Juul
S E
SE
Department of Pediatrics, University of Florida College of Medicine, Gainesville 32610-0296, USA.
Harcum
J
J
Li
Y
Y
Christensen
R D
RD
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000134:cerebrospinal fluid; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D004921:Erythropoietin / Q000134:cerebrospinal fluid* / Q000627:therapeutic use; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn / Q000134:cerebrospinal fluid*; D007234:Infant, Premature / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D011994:Recombinant Proteins / Q000627:therapeutic use
D011994:Recombinant Proteins; D004921:Erythropoietin