title: Potential efficacy of low metal diets and dental metal elimination in the management of atopic dermatitis: an open clinical study.
abstract: We performed an open clinical study on the effects of low metal diets and/or dental metal elimination on 27 patients with moderate to severe atopic dermatitis (AD), who showed positive patch tests for metal allergens and/or clinical exacerbation by oral provocation tests with metal salts. All the patients were recommended to ingest low metal diets for 3 months and/or undergo dental metal elimination. Marked or moderate improvement was noted in 18 patients (67%); 7 patients (26%) showed marked improvement and 11 patients (41%), moderate improvement. Nine patients (33%) showed minimal improvement or no change. In the patients who showed marked or moderate improvement, we observed statistically significant decreases (p < 0.05) in both peripheral blood eosinophil counts and serum LDH levels after 3 months of treatment. The present study suggests that restriction of ingested metal allergens to which patients have positive patch tests and/or oral challenge tests may be useful in the management of some patients with AD who have metal sensitivity.
authors.affiliation: Department of Dermatology, Kobe University School of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Adachi
authors.forename: T
authors.initials: T
authors.lastname: Horikawa
authors.forename: T
authors.initials: T
authors.lastname: Takashima
authors.forename: T
authors.initials: T
authors.lastname: Komura
authors.forename: A
authors.initials: A
authors.lastname: Komura
authors.forename: M
authors.initials: M
authors.lastname: Tani
authors.forename: M
authors.initials: M
authors.lastname: Ichihashi
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000009:adverse effects; D002648:Child; D003722:Dental Alloys / Q000009:adverse effects; D003876:Dermatitis, Atopic / Q000097:blood / Q000178:diet therapy / Q000628:therapy*; D004804:Eosinophils / Q000473:pathology; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000178:diet therapy / Q000628:therapy; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D008670:Metals / Q000008:administration & dosage* / Q000009:adverse effects; D010328:Patch Tests; D012074:Remission Induction
chemical_list: D000485:Allergens; D003722:Dental Alloys; D008670:Metals; D007770:L-Lactate Dehydrogenase