title: Hepatic manifestation of malignant histiocytosis: a case study.
abstract: Malignant histiocytosis, as defined by Rappaport, is now known as a manifestation of malignant lymphoma, the majority of which is the T-cell type. However, unlike the typical presentation of most non-Hodgkin lymphomas, this condition presents with atypical features mimicking acute hepatitis or infectious mononucleosis. The latter diagnosis is often made because of the occurrence of atypical mononuclear cells on the peripheral blood films. This is clearly seen in the seven patients we report where the initial diagnoses were that of viral fever or hepatitis. Some characteristics were found in these patients to differentiate the condition from infectious mononucleosis (IMS) and acute hepatitis (AH): paucity of lymph nodes, cholestasis and prolonged prothrombin time (PT) which is atypical IMS; persistent fever, thrombocytopaenia and disproportionately high aspartate aminotransferase which is unusual in AH in the absence of any drug or alcohol history. The PT is the most important prognosis factor. Early diagnosis and treatment led to improved survival in an otherwise aggressive and rapidly fatal condition.
authors.affiliation: Department of Gastroenterology, Singapore General Hospital, Singapore.
authors.forename: W C
authors.initials: WC
authors.lastname: Chow
authors.forename: Y C
authors.initials: YC
authors.lastname: Linn
authors.forename: R S
authors.initials: RS
authors.lastname: Chong
authors.forename: H S
authors.initials: HS
authors.lastname: Ng
authors.forename: K Y
authors.initials: KY
authors.lastname: Ng
authors.forename: J
authors.initials: J
authors.lastname: Ho
authors.forename: P
authors.initials: P
authors.lastname: Tan
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001707:Biopsy, Needle; D001772:Blood Cell Count; D003937:Diagnosis, Differential; D005260:Female; D006505:Hepatitis / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D054747:Histiocytic Sarcoma / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008111:Liver Function Tests; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011517:Prothrombin Time; D015996:Survival Rate