Antibody to the host cellular gene-derived epitope GOR-1 in liver transplant recipients with hepatitis C virus infection.
The presence of anti-GOR was determined in paired pre-orthotopic liver transplantation (pre-OLT) and post-OLT sera from 87 OLT patients with hepatitis C virus infection. Before OLT, 48/87 patients were seropositive for anti-GOR, but this marker had no relationship with the clinical and biochemical parameters, or viremia level. Anti-GOR was less commonly detected in patients infected with genotype 3a, compared with genotypes 1 and 2, which might be related to the less conserved nature of the proposed shared epitope (amino acid sequence 9-18) in genotype 3a isolates. After OLT (median follow-up 16 months), anti-GOR was detected in 31/87 patients and it had no correlation with the clinical and biochemical parameters, viremia level, histologic disease activity, and clinical outcome. Changes in anti-GOR status (before OLT versus after OLT) were also not related to any of the clinical parameters. Although anti-GOR is commonly detected in OLT patients infected with hepatitis C virus genotypes 1 and 2, it has no clinical or prognostic significance.
Reiser
M
M
Department of Medicine, University of Florida, Gainesville 32610, USA.
Terrault
N
N
Nelson
D R
DR
Mizokami
M
M
Ferrell
L
L
Lake
J R
JR
Roberts
J P
JP
Ascher
N L
NL
Wright
T L
TL
Lau
J Y
JY
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D000939:Epitopes; D005260:Female; D016174:Hepacivirus / Q000145:classification; D006526:Hepatitis C / Q000276:immunology* / Q000821:virology; D018937:Hepatitis C Antibodies / Q000032:analysis; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged
D001323:Autoantibodies; D000939:Epitopes; D018937:Hepatitis C Antibodies