Intravenous alpha-1-antitrypsin replacement therapy: case report after one year of treatment.
Alpha-1-antitrypsin deficiency is an autosomally inherited disease in which individuals homozygous for the disorder are prone to develop severe emphysema. We report the case of a 43 yr old man with severe deficiency and advanced emphysema and the first experience in Ireland with intravenous alpha-1-antitrypsin replacement. After 1 yr of replacement therapy we report our experience with dosage and frequency of infusion as well as pulmonary function test data before and during treatment.
Ward
A C
AC
Mater Misericordiae Hospital, Dublin.
Keogh
B A
BA
D000328:Adult; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006801:Humans; D007494:Ireland; D008297:Male; D011656:Pulmonary Emphysema / Q000188:drug therapy* / Q000209:etiology; D012129:Respiratory Function Tests; D015842:Serine Proteinase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D000515:alpha 1-Antitrypsin / Q000008:administration & dosage / Q000627:therapeutic use*
D015842:Serine Proteinase Inhibitors; D000515:alpha 1-Antitrypsin