title: Functional dose-volume histograms for functionally heterogeneous normal organs.
abstract: Functional dose-volume histograms are proposed as an extension of the conventional dose-volume histograms, for quantitative assessment of three-dimensional radiation dose coverage of functionally heterogeneous normal organs. Examples are given to illustrate possible applications of this approach to the treatment of a brain tumour or a lung tumour, in which cases the distribution of the normal organ function can be obtained from functional dose-volume modalities. It is shown that a significant difference exists between the functional dose-volume histograms and the conventional dose-volume histograms when the normal organ function is non-uniformly distributed within the organ. Utilization of functional dose-volume histograms as the input for the calculation of normal tissue complication probabilities is discussed for different normal tissue structures.
authors.affiliation: Department of Radiation and Cellular Oncology, University of Chicago, IL 60637, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Lu
authors.forename: D R
authors.initials: DR
authors.lastname: Spelbring
authors.forename: G T
authors.initials: GT
authors.lastname: Chen
mesh_terms: D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy; D008279:Magnetic Resonance Imaging; D008962:Models, Theoretical; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D019047:Phantoms, Imaging; D011829:Radiation Dosage; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon