title: Tumor interstitial fluid: misconsidered component of the internal milieu of a solid tumor.
abstract: The tumor interstitial fluid (TIF) is a fluid phase present in the extracellular space of all tumors whose importance in oncology is seldom recognized. In order to stimulate other researchers to give it the due importance, a review of the available data (including our own) is provided. An hypothesis is presented for the genesis, fate and role of the TIF in the processes of invasion, growth and metastatization. Open questions regarding the TIF's role in tumor response to therapy are raised.
authors.affiliation: Department of Animal Biology, University of Pavia, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Freitas
authors.forename: G F
authors.initials: GF
authors.lastname: Baronzio
authors.forename: B
authors.initials: B
authors.lastname: Bono
authors.forename: P
authors.initials: P
authors.lastname: Griffini
authors.forename: V
authors.initials: V
authors.lastname: Bertone
authors.forename: N
authors.initials: N
authors.lastname: Sonzini
authors.forename: G R
authors.initials: GR
authors.lastname: Magrassi
authors.forename: L
authors.initials: L
authors.lastname: Bonandrini
authors.forename: G
authors.initials: G
authors.lastname: Gerzeli
mesh_terms: D000818:Animals; D005110:Extracellular Space / Q000502:physiology*; D006801:Humans; D009336:Necrosis; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology* / Q000628:therapy