title: [Scintigraphic method in the quantification of morphological and functional changes of thyroid autonomy before and after iodine radiotherapy].
abstract: The regional excess of function and cell mass in potentially "toxic" thyroid areas with nonimmunogenic hyperthyroidism (NIH) (unifocal [UFA, previously "toxic adenoma"] and multifocal functional autonomies [MFA or "toxic goiter"]) are quantified by an enhanced diagnostic method: double isotope subtraction scintigraphy (Ssc) with radioiodine and 99mTc-MIBI. In 125 patients, a toxicity index T was derived from the Ssc (*J-*MIBI), and a cell density index Q from the *MIBI image. The median value of T, as an expression of the regional autonomous excess function (165 in UFA, 15 in MFA), by far exceeded the median value of Q (3.8 in UFA, 2.0 in MFA). The significant (p < 0.001) effects of radioiodine therapy (RIT) were monitored by the changes towards normalization of T and Q in 53 patients in follow-ups 3 and 9 months thereafter. Our aim was (a) to extend the conventional field of measurement of NIH-hyperthyroidism with the scintigraphically quantified function and morphology, and (b) to compare the return to euthyroid state with scintigraphic scarification of the functionally autonomous areas.
authors.affiliation: Abteilung Nuklearmedizin, Inselspital, Universität Bern.
authors.forename: C
authors.initials: C
authors.lastname: Als
authors.forename: M
authors.initials: M
authors.lastname: Listewnik
authors.forename: H P
authors.initials: HP
authors.lastname: Ritter
authors.forename: H
authors.initials: H
authors.lastname: Rösler
mesh_terms: D003287:Contrast Media; D005500:Follow-Up Studies; D006801:Humans; D006980:Hyperthyroidism / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000532:radiotherapy*; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D011877:Radionuclide Imaging; D013382:Subtraction Technique; D017256:Technetium Tc 99m Sestamibi; D013961:Thyroid Gland / Q000033:anatomy & histology / Q000378:metabolism
chemical_list: D003287:Contrast Media; D007457:Iodine Radioisotopes; D017256:Technetium Tc 99m Sestamibi
vernacular_title: Szintigraphisches Verfahren zur Quantifizierung der morphologischen und funktionellen Veränderungen der thyreoidalen Autonomie vor und nach Radiojodtherapie.