title: Sustained closure of surgically repaired macular holes after retinal detachment with submacular fluid.
abstract: OBJECTIVE
  To examine the behavior of surgically repaired macular holes when subsequent retinal detachment with submacular fluid develops and to correlate these observations with current theories of macular hole formation and closure.
  
  
  METHODS
  We reviewed the medical records of four patients who underwent successful surgical closure of macular holes and subsequently developed rhegmatogenous retinal detachment with macular involvement.
  
  
  RESULTS
  No reopening of the original macular hole occurred in any of the four patients. No focal macular attachment was seen that would suggest firm adherence of the macular hole edges to the underlying retinal pigment epithelium.
  
  
  CONCLUSIONS
  When retinal detachment with submacular fluid develops in patients with a successfully closed macular hole, sustained closure of the macular dehiscence is typically seen. These findings support reapproximation of the hole edges with an associated retinal wound healing response as the mechanism of hole closure.
authors.affiliation: Duke University Eye Center, Durham, North Carolina 27710, USA.
authors.forename: D P
authors.initials: DP
authors.lastname: Hainsworth
authors.forename: M W
authors.initials: MW
authors.lastname: Johnson
authors.forename: G J
authors.initials: GJ
authors.lastname: Jaffe
mesh_terms: D000368:Aged; D001826:Body Fluids; D003452:Cryosurgery; D005260:Female; D005451:Fluorescein Angiography; D005466:Fluorocarbons / Q000008:administration & dosage; D005654:Fundus Oculi; D006801:Humans; D008266:Macula Lutea / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011187:Posture; D012163:Retinal Detachment / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D012167:Retinal Perforations / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery*; D012591:Scleral Buckling; D013459:Sulfur Hexafluoride / Q000008:administration & dosage; D014792:Visual Acuity; D014821:Vitrectomy; D014945:Wound Healing / Q000502:physiology
chemical_list: D005466:Fluorocarbons; C042852:perflutren; D013459:Sulfur Hexafluoride