Cellular environments and apoptosis: tissue microenvironments control activated T-cell death.
Activated T cells must be removed by apoptosis at the end of an immune response in order to maintain cellular homeostasis. Although recent attention has focused on the role of CD95 (Fas/APO-1) in the elimination of activated T cells, apoptosis can also be induced by cytokine deprivation. Here, Arne Akbar and Mike Salmon describe how both death pathways interact in activated T cells and are profoundly influenced by different tissue microenvironments.
Akbar
A N
AN
Dept of Clinical Immunology, Royal Free Hospital School of Medicine, Hampstead, London, UK. akbar@fhsm.ac.uk
Salmon
M
M
D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology*; D014018:Tissue Distribution / Q000276:immunology