A member of the Frizzled protein family mediating axis induction by Wnt-5A.
In Xenopus laevis embryos, the Wingless/Wnt-1 subclass of Wnt molecules induces axis duplication, whereas the Wnt-5A subclass does not. This difference could be explained by distinct signal transduction pathways or by a lack of one or more Wnt-5A receptors during axis formation. Wnt-5A induced axis duplication and an ectopic Spemann organizer in the presence of hFz5, a member of the Frizzled family of seven-transmembrane receptors. Wnt-5A/hFz5 signaling was antagonized by glycogen synthase kinase-3 and by the amino-terminal ectodomain of hFz5. These results identify hFz5 as a receptor for Wnt-5A.
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National Cancer Institute, Building 49, Room 4A56, National Institutes of Health, Bethesda, MD 20892, USA. xhe.nhgri.nih.gov
Saint-Jeannet
J P
JP
Wang
Y
Y
Nathans
J
J
Dawid
I
I
Varmus
H
H
D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics; D029721:Drosophila Proteins; D047108:Embryonic Development; D004627:Embryonic Induction; D051157:Frizzled Receptors; D038362:Glycogen Synthase Kinase 3; D038341:Glycogen Synthase Kinases; D051956:Goosecoid Protein; D018398:Homeodomain Proteins; D006801:Humans; D008024:Ligands; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled; D012097:Repressor Proteins; D015398:Signal Transduction; D014157:Transcription Factors; D051153:Wnt Proteins; D000071818:Wnt-5a Protein; D029867:Xenopus Proteins; D014982:Xenopus laevis / Q000196:embryology
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D051157:Frizzled Receptors; D051956:Goosecoid Protein; D018398:Homeodomain Proteins; D008024:Ligands; D008565:Membrane Proteins; D011506:Proteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D012097:Repressor Proteins; D014157:Transcription Factors; D051153:Wnt Proteins; D000071818:Wnt-5a Protein; C085096:Wnt5a protein, Xenopus; D029867:Xenopus Proteins; C058784:fz protein, Drosophila; D038341:Glycogen Synthase Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D038362:Glycogen Synthase Kinase 3