title: Elevated soluble intercellular adhesion molecules-1 in inflammatory myopathy.
abstract: BACKGROUND
  We evaluated the serum level of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with polymyositis (PM) and dermatomyositis (DM) and investigated the correlation between the serum level of sICAM-1 and clinical findings.
  
  
  METHODS
  We measured the serum level of sICAM-1 using an enzyme-linked immunosorbent assay in 19 untreated patients with inflammatory myopathy (14 patients with PM and 5 patients with DM), 20 patients with other neuromuscular disorders in which immunological mechanisms are unlikely to be involved, and 14 normal healthy controls.
  
  
  RESULTS
  The serum level of sICAM-1 was significantly higher in patients with PM/DM compared with patients with other neurological disorders and control subjects. The sICAM-1 level was, however, not correlated with the clinical characteristic including disease severity, the duration of illness, and the serum level of CK.
  
  
  CONCLUSIONS
  These findings suggest that sICAM-1 is involved in the inflammatory process of PM and DM.
authors.affiliation: Third Department of Internal Medicine, Oita Medical University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kumamoto
authors.forename: T
authors.initials: T
authors.lastname: Abe
authors.forename: H
authors.initials: H
authors.lastname: Ueyama
authors.forename: R
authors.initials: R
authors.lastname: Sugihara
authors.forename: T
authors.initials: T
authors.lastname: Shigenaga
authors.forename: T
authors.initials: T
authors.lastname: Tsuda
mesh_terms: D000328:Adult; D000368:Aged; D003882:Dermatomyositis / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017285:Polymyositis / Q000097:blood*; D012720:Severity of Illness Index
chemical_list: D018799:Intercellular Adhesion Molecule-1