title: The significance of pre-epiglottic space invasion in supraglottic laryngeal carcinomas.
abstract: It is widely accepted that tumoral invasion of the pre-epiglottic space (PES) has a significant prognostic importance in supraglottic laryngeal carcinomas. The lymphatics of the supraglottic larynx drain to cervical lymph nodes via the PES. Since the supraglottic larynx is an embryological unit that contains the PES, malignant lesions of this region must be resected with en bloc surgery, including the PES. Tumors with PES invasion are already considered to be T3 in TNM staging. The purpose of this study was to review the clinical experience we have had with these tumors at Ankara University. The study comprised 150 patients with squamous cell carcinomas of the supraglottic larynx treated with either partial or total laryngectomies. Findings suggested that PES invasion occurred at early stages of supraglottic tumor progression. Suprahyoid epiglottic lesions behaved less aggressively than tumors originating from other supraglottic subsites and did not invade the PES until advanced stages. PES invasion was not considered to be a significant prognostic factor because the majority of the supraglottic lesions studied demonstrated PES invasion regardless of cervical lymph node metastases. Analysis of oncological and functional results revealed that en bloc resection of the supraglottis with the PES was facilitated by preservation of the hyoid bone.
authors.affiliation: Department of Ears, Nose and Throat, Ankara University Medical School, Mebusevleri, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Dursun
authors.forename: R
authors.initials: R
authors.lastname: Keser
authors.forename: T
authors.initials: T
authors.lastname: Aktürk
authors.forename: M N
authors.initials: MN
authors.lastname: Akìner
authors.forename: A
authors.initials: A
authors.lastname: Demireller
authors.forename: S D
authors.initials: SD
authors.lastname: Sak
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D018450:Disease Progression; D004825:Epiglottis / Q000473:pathology*; D005260:Female; D005931:Glottis / Q000473:pathology* / Q000601:surgery; D006801:Humans; D006928:Hyoid Bone / Q000473:pathology; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery; D007825:Laryngectomy / Q000379:methods; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008208:Lymphatic System / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009333:Neck; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D014421:Turkey