title: T-cell receptors: feeling out the complex.
abstract: Recent crystallographic studies show that the T-cell receptor has a largely immunoglobulin-like structure and binds to MHC-peptide complexes through loops from paired Valpha and Vbeta domains that focus on the central amino acids of the MHC-bound peptide, and to bacterial superantigens via peripheral aspects of the Vbeta domain.
authors.affiliation: Laboratory of Molecular Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-1892, USA.
authors.forename: E A
authors.initials: EA
authors.lastname: Padlan
authors.forename: D H
authors.initials: DH
authors.lastname: Marguilies
mesh_terms: D006801:Humans; D007136:Immunoglobulins / Q000737:chemistry; D008285:Major Histocompatibility Complex / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry*
chemical_list: D007136:Immunoglobulins; D011948:Receptors, Antigen, T-Cell