title: [Comparative study between seric I pepsinogen and seric gastrin, in the differentiation of the different types and localizations of chronic gastritis].
abstract: The present work analyzes the serie levels of pepsinogen I (PG I) and gastrin in relation to the histopathological findings with the optical microscope (OM) and electron microscope (EM) of different gastric mucosa biopsies obtained through fibrogastroscopy. 45 patients were studied (19 men and 26 women) with an average age of 63 with different clinical diagnoses documented later by fibrogastroscopy (peptic ulcer, neoplasia etc.), whose previous consent, two biopsies were taken at an antrum level and two biopsies at a fundic-body area level, analyzed later by OM and EM. The anatomopathological criteria followed in order to classify the condition of the mucosa was Whitehead's classification. The PG I and gastrin determination was carried out with RIA against a control group of 25 healthy individuals. Our study allows us to conclude that the normal or high serie concentration of PG I reflects a functional integrity of the fundic-body area, and low levels imply the presence of atrophic chronic gastritis at a fundic-body level. Thus a low level of PG I is a reliable marker of the atrophic condition of the mucosa and it can be considered as a precancerous factor.
authors.affiliation: Departamento de Medicina Interna, Hospital Clínico Universitario, Salamanca.
authors.forename: A
authors.initials: A
authors.lastname: Sánchez Rodríguez
authors.forename: J A
authors.initials: JA
authors.lastname: Martín Oterino
authors.forename: V
authors.initials: V
authors.lastname: Chimpen Ruiz
authors.forename: P
authors.initials: P
authors.lastname: Alonso Hernández
authors.forename: P
authors.initials: P
authors.lastname: Araoz Sánchez
authors.forename: J
authors.initials: J
authors.lastname: Portugal Alvarez
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D002908:Chronic Disease; D005260:Female; D005755:Gastrins / Q000097:blood*; D005756:Gastritis / Q000097:blood* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010435:Pepsinogens / Q000097:blood*; D013274:Stomach Neoplasms / Q000097:blood
chemical_list: D015415:Biomarkers; D005755:Gastrins; D010435:Pepsinogens
vernacular_title: Estudio comparativo de pepsinógeno I sérico y gastrina sérica en la diferenciación de los distintos tipos y localizaciones de gastritis crónica.