title: Food allergy in human immunodeficiency virus (HIV) infection.
abstract: BACKGROUND
  Gastrointestinal complaints and pruritic skin conditions are common in patients infected with human immunodeficiency virus (HIV). Because atopic disorders such as drug allergy, asthma, and allergic rhinitis are apparently increased, we hypothesized that food allergy may also be more common in patients with HIV.
  
  
  OBJECTIVE
  The purpose of this study was to estimate the prevalence of food allergy in patients infected with HIV.
  
  
  METHODS
  Consecutive patients visiting our outpatient adult HIV clinic were screened for possible food allergy by use of a questionnaire. One hundred seventy-six patients responded. Sixty-two of these patients reported symptoms compatible with a possible food allergy. Followup of the 62 subjects was possible in 40. Thirty-one patients were skin tested for foods thought to produce reactions.
  
  
  RESULTS
  Three patients (1.7%) described previous anaphylactic responses to specific foods and were therefore not skin tested or challenged orally. Six patients (3.4%) described very strong histories of food allergy but either refused or were too ill for testing. Twenty-nine of the 31 patients had negative skin tests. One of the two patients with a positive skin test to a suspected food also had a positive double-blind, placebo-controlled food challenge (DBPCFC). There was no correlation between CD4 cell count and likelihood of food allergy. Based on a strong history alone, the maximal estimated prevalence of food allergy in this group was 5.7% (10 of 176). By using the more strict criterion of positive DBPCFC, the prevalence of food allergy in this patient population was 0.57% (1 of 176).
  
  
  CONCLUSIONS
  These results suggest that food allergy is an uncommon disease in patients with HIV infection with an estimated prevalence similar to that found in the general adult population. Our data do not suggest an obvious direct correlation between HIV infection and food allergy.
authors.affiliation: Department of Medicine, Harbor-UCLA Medical Center, Torrance, California, USA.
authors.forename: V C
authors.initials: VC
authors.lastname: Tubiolo
authors.forename: L A
authors.initials: LA
authors.lastname: Vazzo
authors.forename: G N
authors.initials: GN
authors.lastname: Beall
mesh_terms: D000328:Adult; D000707:Anaphylaxis; D018791:CD4 Lymphocyte Count; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D015995:Prevalence; D011852:Radioallergosorbent Test; D012882:Skin Tests / Q000009:adverse effects; D011795:Surveys and Questionnaires