title: A 2.8 megabase YAC contig spanning D8S339, which is tightly linked to the Werner syndrome locus.
abstract: A number of gene loci, including the locus for Werner syndrome (WRN), map to proximal human chromosome 8p near the genetic marker D8S339. In this report, we present a long range physical map of an approximately 2.8 megabase yeast artificial chromosome contig centred on D8S339. In this map, we localize the WRN-linked polymorphic sequence-tagged sites (STS) D8S339 and D8S1055, as well as a novel polymorphic STS, D8S2297. We also refine the positions of three known gene loci, GTF2E2, GSR, and PPP2CB, relative to the location of WRN within the map.
authors.affiliation: Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Bruskiewich
authors.forename: M
authors.initials: M
authors.lastname: Schertzer
authors.forename: S
authors.initials: S
authors.lastname: Wood
mesh_terms: D002460:Cell Line; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D002898:Chromosomes, Human, Pair 8; D003360:Cosmids; D005819:Genetic Markers; D006801:Humans; D011110:Polymorphism, Genetic; D016324:Sequence Tagged Sites; D014898:Werner Syndrome / Q000235:genetics*
chemical_list: D005819:Genetic Markers