title: Functional echoplanar brain imaging correlates of amphetamine administration to normal subjects and subjects with the narcoleptic syndrome.
abstract: Two subjects with narcoleptic syndrome and three healthy volunteers underwent functional magnetic resonance imaging during the simultaneous presentation of periodic auditory and visual stimuli both before and after administration of amphetamine. The effect of amphetamine in control subjects was a small reduction in the extent of sensory-induced activation. In the narcoleptic subjects, amphetamine led to an increase in the extent of induced activation within primary and association sensory cortex.
authors.affiliation: Department of Old Age Psychiatry, Institute of Psychiatry, Camberwell, London, UK.
authors.forename: R J
authors.initials: RJ
authors.lastname: Howard
authors.forename: C
authors.initials: C
authors.lastname: Ellis
authors.forename: E T
authors.initials: ET
authors.lastname: Bullmore
authors.forename: M
authors.initials: M
authors.lastname: Brammer
authors.forename: J D
authors.initials: JD
authors.lastname: Mellers
authors.forename: P W
authors.initials: PW
authors.lastname: Woodruff
authors.forename: A S
authors.initials: AS
authors.lastname: David
authors.forename: A
authors.initials: A
authors.lastname: Simmons
authors.forename: S C
authors.initials: SC
authors.lastname: Williams
authors.forename: J D
authors.initials: JD
authors.lastname: Parkes
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000661:Amphetamine / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology*; D001931:Brain Mapping; D017352:Echo-Planar Imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000175:diagnosis / Q000503:physiopathology*; D010775:Photic Stimulation
chemical_list: D000661:Amphetamine