Recognition of telomeric DNA.
The three-dimensional structure of the yeast telomere-binding protein RAP1 in complex with DNA provides the first insight into telomeric DNA recognition. RAP1 binds to DNA via two Myb/homeodomain-like motifs, which are DNA-binding folds previously identified in transcription factors. This, together with the finding that human TRF1 and other telomere-binding factors contain Myb-like motifs, has led us to speculate that a conserved protein fold might be used for telomeric DNA recognition.
König
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Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Rhodes
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000378:metabolism*; D004271:DNA, Fungal / Q000235:genetics / Q000378:metabolism; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D016615:Telomere / Q000378:metabolism*; D020668:rap GTP-Binding Proteins
D004271:DNA, Fungal; D005656:Fungal Proteins; D004247:DNA; D019204:GTP-Binding Proteins; D020668:rap GTP-Binding Proteins