Metaplastic bone formation in the subcutaneous nodule of a patient with mixed connective tissue disease.
Cutaneous ossification is a rare phenomenon in collagen diseases, despite the rather frequent occurrence in these diseases of dystrophic calcinosis. We observed metaplastic woven bone formation associated with calcification in biopsy material obtained from a 49-year-old woman suffering from mixed connective tissue disease together with multiple subcutaneous indurations. This is the first case of the presence of metaplastic bone formation in a patient with mixed connective tissue disease.
Nakagawa
S
S
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan.
Tagami
H
H
D005260:Female; D006801:Humans; D008679:Metaplasia; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000473:pathology*; D009999:Ossification, Heterotopic / Q000473:pathology*