Technical considerations on intra-arterial papaverine hydrochloride for cerebral vasospasm.
Intra-arterial infusion of papaverine hydrochloride for subarachnoid hemorrhage-induced cerebral vasospasm has become an adjunctive endovascular therapy along with cerebral angioplasty. Our knowledge concerning the mechanism of action, method of administration and potential side effects of this therapeutic alternative are reviewed.
Mathis
J M
JM
Radiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA.
Jensen
M E
ME
Dion
J E
JE
D000800:Angioplasty, Balloon; D002533:Cerebral Angiography / Q000187:drug effects; D003131:Combined Modality Therapy; D006801:Humans; D007269:Injections, Intra-Arterial; D002546:Ischemic Attack, Transient / Q000000981:diagnostic imaging / Q000188:drug therapy*; D010208:Papaverine / Q000008:administration & dosage* / Q000009:adverse effects; D013345:Subarachnoid Hemorrhage / Q000000981:diagnostic imaging / Q000188:drug therapy*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000009:adverse effects
D014665:Vasodilator Agents; D010208:Papaverine