Antimutagenic activity of caffeic acid and related compounds.
Effects of caffeic acid and chlorogenic acid on mutagenicity were studied using the Salmonella typhimurium system. These compounds had inhibitory effects on the mutagenicity of Trp-P-1 and Glu-P-2. Caffeic acid completely eliminated the mutagenicity induced by activated Glu-P-2. Some compounds analogous to caffeic acid, such as cinnamic acid, coumaric acid, and ferulic acid, also significantly decreased the mutagenicity of Glu-P-2.
Yamada
J
J
Laboratory of Food Science, Faculty of Education, Yamaguchi University, Japan.
Tomita
Y
Y
D016587:Antimutagenic Agents / Q000494:pharmacology*; D002109:Caffeic Acids / Q000494:pharmacology*; D002726:Chlorogenic Acid / Q000494:pharmacology*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity
D016587:Antimutagenic Agents; D002109:Caffeic Acids; D009153:Mutagens; D002726:Chlorogenic Acid; C040048:caffeic acid