title: Rapid formation of cholesterol crystals in gallbladder bile is associated with stone recurrence after laparoscopic cholecystotomy.
abstract: Laparoscopic cholecystotomy (LCT) with subsequent extraction of gallstones and primary closure of the gallbladder has been introduced as an alternative therapy for patients with cholecystolithiasis and preserved gallbladder function. However, stone recurrence has to be considered as a major drawback that might be related to lithogenic factors of gallbladder bile or the composition of gallbladder stones. Therefore, these were studied in relation to stone recurrence within an observation period of 1 to 5 years (median, 3.6 years) in 50 patients after LCT. The concentrations of total and individual bile acids, phospholipids, cholesterol, total lipids, mucin, protein, and the cholesterol saturation indices in gallbladder bile were not significantly different between 10 patients with and 40 patients without stone recurrence. However, the crystal observation time was significantly (P < .02) shorter (range, 1-2 days; median, 1.5) in the bile of patients with stone recurrence compared to those without (range, 1-21 days, median 3.5). Moreover, all 10 stone recurrences were observed in the 28 patients with a crystal observation time in the bile of less than or equal to 2 days (approximate annual risk: 12%-15%), and no recurrences were observed in the 22 patients with a crystal observation time greater than 2 days (P < .0001) or in patients with pigment stones. The rapid formation of cholesterol monohydrate crystals in bile seems to be the major risk factor for recurrent stones after LCT. These are most likely cholesterol stones and, therefore, are amenable to oral bile-acid prevention or treatment.
authors.affiliation: Department of Medicine II, Klinikum Grosshadern and Department of Medical Informatics, Technical University of Munich, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Jüngst
authors.forename: R
authors.initials: R
authors.lastname: del Pozo
authors.forename: M H
authors.initials: MH
authors.lastname: Dolu
authors.forename: S G
authors.initials: SG
authors.lastname: Schneeweiss
authors.forename: E
authors.initials: E
authors.lastname: Frimberger
mesh_terms: D001646:Bile / Q000737:chemistry; D017081:Cholecystectomy, Laparoscopic; D002769:Cholelithiasis / Q000737:chemistry* / Q000601:surgery; D002784:Cholesterol / Q000737:chemistry*; D003460:Crystallization; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D013997:Time Factors
chemical_list: D002784:Cholesterol