title: Atypical fibroxanthoma. An unusual variant with osteoclast-like giant cells.
abstract: We report three cases of an unusual variant of atypical fibroxanthoma with numerous multinucleated osteoclast-like giant cells. Histologically, the lesions were composed of uniformly dispersed multinucleated osteoclast-like giant cells within a pleomorphic cellular proliferation with microscopic and histochemical features of atypical fibroxanthoma. Multinucleated osteoclast-like giant cells, however, stained with KP-1, a macrophage-associated antigen only. These cells are not necessarily an integral part of the tumor and may represent a reactive histiocytic component.
authors.affiliation: Department of Dermatopathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Tomaszewski
authors.forename: G P
authors.initials: GP
authors.lastname: Lupton
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D015726:Giant Cells / Q000166:cytology*; D018219:Histiocytoma, Benign Fibrous / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D010010:Osteoclasts / Q000166:cytology; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology*; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule