Mapping in the region of Danforth's short tail and the localization of tail length modifiers.
We have used an interspecific backcross to generate a detailed genetic map around the mouse tail and kidney developmental mutation Danforth's short tail (Sd). The map includes 14 simple sequence repeat (SSR) markers and four genes in a 5-cM region encompassing Sd. In addition we have used a DNA pooling approach to carry out a genome scan to localize quantitative trait loci (QTL) that modify the tail length of Sd progeny of the backcross. This has allowed us to identify a major QTL on chromosome 10 in the region of nodal and three other putative tail length QTL on chromosomes 1, 9, and 18.
Alfred
J B
JB
Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, UK. janea@hgu.mrc.ac.uk
Rance
K
K
Taylor
B A
BA
Phillips
S J
SJ
Abbott
C M
CM
Jackson
I J
IJ
D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D016678:Genome; D006239:Haplotypes; D006801:Humans; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008817:Mice, Mutant Strains / Q000235:genetics; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D017422:Sequence Analysis, DNA; D013623:Tail / Q000002:abnormalities
D005819:Genetic Markers