Temporal study of immunoglobin M seroreactivity to Borrelia burgdorferi in patients treated for Lyme borreliosis.
Forty-six patients with late Lyme disease who were considered improved or cured following treatment were monitored by immunoglobin M (IgM) immunoblotting (mean monitoring period, 27.6 months). There was a persistent IgM response in 32 (97%) of 33 initially positive patients. All but three showed a consistent number, type, and intensity of IgM bands over the entire follow-up period. IgM immunoblotting may not be useful for monitoring the response to treatment of Lyme borreliosis.
Hilton
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E
Division of Clinical Research, Long Island Jewish Medical Center, the Long Island Campus for Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA.
Tramontano
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A
DeVoti
J
J
Sood
S K
SK
D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D015748:Borrelia burgdorferi Group / Q000276:immunology*; D005260:Female; D006801:Humans; D015151:Immunoblotting; D007075:Immunoglobulin M / Q000097:blood*; D008193:Lyme Disease / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012698:Serologic Tests; D013997:Time Factors
D000907:Antibodies, Bacterial; D007075:Immunoglobulin M