Damage to Pseudomonas aeruginosa PAO1 bacteriophage F116 DNA by biocides.
The mechanism of action of biocides against viruses has not been widely studied, although two main targets are viral proteins (capsids, enzymes) and the viral genome. This study was undertaken in order to investigate the efficacy of several disinfectants against the nucleic acid of the Pseudomonas aeruginosa PAO bacteriophage F116. Of all the biocides tested, only peracetic acid affected significantly the phage genome. However, it is not clear whether the nucleic acid was damaged inside the phage capsid or when released into the surrounding medium.
Maillard
J Y
JY
Welsh School of Pharmacy, University of Wales College of Cardiff, UK.
Beggs
T S
TS
Day
M J
MJ
Hudson
R A
RA
Russell
A D
AD
D000433:1-Propanol / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology*; D002594:Cetylpyridinium / Q000494:pharmacology; D002710:Chlorhexidine / Q000494:pharmacology; D004249:DNA Damage; D004279:DNA, Viral / Q000187:drug effects* / Q000302:isolation & purification; D000431:Ethanol / Q000494:pharmacology; D005976:Glutaral / Q000494:pharmacology; D010463:Peracetic Acid / Q000494:pharmacology; D019800:Phenol; D010636:Phenols / Q000494:pharmacology; D017105:Pseudomonas Phages / Q000187:drug effects* / Q000235:genetics; D011550:Pseudomonas aeruginosa / Q000821:virology*
D000998:Antiviral Agents; D004279:DNA, Viral; D010636:Phenols; D019800:Phenol; D000431:Ethanol; D000433:1-Propanol; D002594:Cetylpyridinium; D010463:Peracetic Acid; D002710:Chlorhexidine; D005976:Glutaral