[Are environmental chemicals with hormone-like properties a health problem?].
Lately, a hypothesis linking higher frequency of testicular cancer, reduced semen quality and malformation of the male sexual organs with increased embryonic/foetal exposure to oestrogenic chemicals has received wide attention in the media. There are several examples where point-source chemical pollution has been convincingly associated with endocrine-related changes in wildlife. Such changes have also been reproduced in experimental studies. There is very little evidence, however, of such an association in humans. Nevertheless, the findings provide a clear challenge to toxicologists and epidemiologists in order to elucidate possible public health risks from environmental exposure to chemicals with hormone-like effects. Better test strategies and reproductive toxicity test guidelines are needed in order to assess any such risks, and to provide a basis for possible regulatory action.
Holme
J A
JA
Avdeling for miljømedisin Statens institutt for folkehelse, Oslo.
Dybing
E
E
D000818:Animals; D004785:Environmental Pollutants / Q000009:adverse effects* / Q000633:toxicity; D004967:Estrogens / Q000009:adverse effects* / Q000633:toxicity; D005260:Female; D006801:Humans; D008297:Male; D012098:Reproduction / Q000187:drug effects; D012307:Risk Factors; D013737:Testis / Q000187:drug effects; D018675:Toxicity Tests
D004785:Environmental Pollutants; D004967:Estrogens
Miljøkjemikalier med hormonliknende effekter et helseproblem?