title: [Pathogenesis of complicated cataract in herpetic kerato-uveitis].
abstract: BACKGROUND
  Keratitis, retinitis and secondary cataract are well known complications of ocular herpes simplex infection. We report on a case of herpetic keratouveitis and cataract. Acute and inflammatory pathogenesis of cataract formation resemble a phacoanaphylactic reaction.
  
  
  METHODS
  A 15-year-old girl with recurrent herpes keratitis was referred for acute spontaneous cataract formation accompanied by iridocyclitis and hypotony. Visual acuity was decreased from 0.4 to light projection. During cataract extraction the anterior chamber was tabbed for immunological analysis. The thickened anterior lens capsule was examined by light microscopy. We found a significant local synthesis of herpes antibodies in the aqueous. Histologically the lens capsule depicted a defect and a granulomatous inflammatory infiltrate towards the basal membrane material. The specimen was not suitable to judge on eventual additional phacoanaphylaxis. After cataract extraction and systemic acyclovir and corticosteroids the keratouveitis subsided. Visual acuity improved to 0.4, but was limited by the disciform corneal scar.
  
  
  CONCLUSIONS
  The granulomatous response towards lens capsule shown here, resembles the granulomatous reaction towards Descemet's membrane in advanced herpetic corneal ulcer. We speculate on the pathogenesis of the lens capsule defect as a, so far unknown, herpes-associated autoimmun response against the basal membrane material of the lens. The acuteness of cataract formation may be a consequence of contact of aqueous with lens fibres. Additional phacoanaphylaxis combined with secondary glaucoma is possible.
authors.affiliation: Universitäts-Augenklinik Köln.
authors.forename: K U
authors.initials: KU
authors.lastname: Bartz-Schmidt
authors.forename: C
authors.initials: C
authors.lastname: Hartmann
authors.forename: B
authors.initials: B
authors.lastname: Kirchhof
authors.forename: G K
authors.initials: GK
authors.lastname: Krieglstein
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage; D000293:Adolescent; D000867:Anterior Chamber / Q000276:immunology / Q000473:pathology; D000914:Antibodies, Viral / Q000378:metabolism; D000998:Antiviral Agents / Q000008:administration & dosage; D001082:Aqueous Humor / Q000276:immunology; D002386:Cataract / Q000276:immunology / Q000473:pathology*; D002387:Cataract Extraction; D003131:Combined Modality Therapy; D003315:Cornea / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D015863:Iridocyclitis / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D016849:Keratitis, Herpetic / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D007903:Lens Capsule, Crystalline / Q000276:immunology / Q000473:pathology / Q000601:surgery; D018139:Simplexvirus / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents; D000212:Acyclovir
vernacular_title: Zur Genese der Cataracta complicata bei herpetischer Keratouveitis.