title: Origin of premenstrual syndrome: assessment by endometrial ablation.
abstract: OBJECTIVE
  To determine the origin of premenstrual syndrome (PMS) by endometrial ablation.
  
  
  METHODS
  Evaluation of 108 consecutive women requiring endometrial ablation.
  
  
  METHODS
  The study was conducted in several hospitals and a surgical center in Fort Worth, Texas. Evaluation of patients was done in-office.
  
  
  METHODS
  The women had disabling uterine bleeding not related to malignancy. Of the 108 women, 6 were having a second procedure.
  
  
  METHODS
  All women underwent endometrial ablation with the rollerbar resectoscope under local stand-by anesthesia, with suction curettage preparation of the uterus.
  
  
  RESULTS
  The 73 women who were identified with PMS were evaluated by a 12-point protocol preoperatively and between 1 and 2 years postoperatively to gain insight into the origin of PMS. After surgery most of them were initially amenorrheic and essentially free of symptoms; however, with recurrence of bleeding PMS often recurred. Persistence of amenorrhea after ablation was associated with continued relief of PMS.
  
  
  CONCLUSIONS
  We postulate that the etiology of PMS in women with disabling menstrual bleeding involves products from or substances in endometrial tissue.
authors.affiliation: 1700 Mistletoe Boulevard, Fort Worth, TX 67104, USA.
authors.forename: H T
authors.initials: HT
authors.lastname: Lefler
authors.forename: C F
authors.initials: CF
authors.lastname: Lefler
mesh_terms: D000328:Adult; D004717:Endometrium / Q000473:pathology / Q000601:surgery*; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015907:Hysteroscopy / Q000379:methods*; D008875:Middle Aged; D011293:Premenstrual Syndrome / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D011336:Probability; D011379:Prognosis; D012008:Recurrence