Spinal anaesthesia with midazolam in the rat.
OBJECTIVE
This study examined in an animal model whether intrathecal midazolam, alone or with fentanyl, can achieve anaesthesia sufficient for laparotomy, comparable to lidocaine. Effects on consciousness and whether anaesthesia was segmental were also examined. The haemodynamic and respiratory changes were compared with those of intrathecal lidocaine or intrathecal fentanyl alone.


METHODS
Sixty Wistar strain rats, with nylon catheters chronically implanted in the lumbar subarachnoid theca, were divided into six groups. Group 1 (n = 12) received 75 microL intrathecal lidocaine 2%. Group 2 (n = 12) received 75 microL intrathecal midazolam 0.1%, Group 3 (n = 12) received intrathecal 37.5 microL midazolam 0.1%, plus 37.5 microL fentanyl 0.005%. Group 4 (n = 12) received intrathecal 50 microL fentanyl 0.005%. Group 5 (n = 6) received 75 microL midazolam 0.1% iv. Group 6 (n = 6) received halothane 0.6% in oxygen by inhalation.


RESULTS
Both groups that received intrathecal midazolam, alone or combined with fentanyl, developed effective segmental sensory and motor blockade of the hind limbs and abdominal wall, sufficient for a pain-free laparotomy procedure. Neither of these groups, unlike the group that received intrathecal lidocaine, developed a reduction in blood pressure or change in heart rate at the time of maximal sensory or motor blockade, nor were there changes in the arterial blood gases or respiratory rate.


CONCLUSIONS
Midazolam, when injected intrathecally, produces reversible, segmental, spinally mediated antinociception, sufficient to provide balanced anaesthesia for abdominal surgery.
Bahar
M
M
Department of Anaesthesiology, Assaf Harofeh, Medical Centre, Zerifin, Israel.
Cohen
M L
ML
Grinshpon
Y
Y
Chanimov
M
M
D000775:Anesthesia, Spinal; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D005283:Fentanyl / Q000494:pharmacology; D006221:Halothane / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D008874:Midazolam / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D018686:Anesthetics, Intravenous; D008012:Lidocaine; D008874:Midazolam; D005283:Fentanyl; D006221:Halothane