title: [A clinico-laboratory evaluation of an immunomodulating drug of bacterial derivation].
abstract: The authors report the results of a study aimed at evaluating the action of an immunomodulating drug of bacterial derivation whose mechanism of action is correlated to both the parietal and ribosomal components of the bacteria capable of stimulating specific and aspecific cell-mediated and humoral immunity. The study reports an increase in IgA-S (in line with other reports), a statistically significant decrease in neutrophilia and the disappearance, in 80% of the cases treated, of salivary bacteria. It is also worth pointing out the reduced IgE fraction. These laboratory results are correlated with a clinical improvement in the subjects treated, all of whom were affected by recurrent catharral or obstructive infections.
authors.affiliation: Divisione di Pneumologia, Ospedale Infantile Regina Margherita, Torino.
authors.forename: D
authors.initials: D
authors.lastname: Castello
authors.forename: D
authors.initials: D
authors.lastname: Franchi
authors.forename: M
authors.initials: M
authors.lastname: Castello
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects / Q000627:therapeutic use*; D001772:Blood Cell Count / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000097:blood / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology; D012463:Saliva / Q000187:drug effects / Q000382:microbiology
chemical_list: D000276:Adjuvants, Immunologic
vernacular_title: Valutazione clinico-laboratoristica di un farmaco immunomodulante di derivazione batterica.