title: Aphthous vaginal ulceration in two women with acquired immunodeficiency syndrome.
abstract: Two women with advanced human immunodeficiency virus infection are described who were seen with painful aphthous vaginal ulceration and CD4+ lymphocyte counts < 50 cells/mm3. A chronic rectovaginal fistula developed in one patient. In spite of extensive investigation no underlying cause of the ulceration was discovered. Clinical therapeutic response suggests that corticosteroid therapy may be of value in healing or stabilizing the destructive process. Clinicians should be aware of this complication in human immunodeficiency virus-infected women with severe vaginal pain and unexplained discharge.
authors.affiliation: Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI, USA.
authors.forename: P
authors.initials: P
authors.lastname: Schuman
authors.forename: C
authors.initials: C
authors.lastname: Christensen
authors.forename: J D
authors.initials: JD
authors.lastname: Sobel
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology / Q000473:pathology; D000328:Adult; D018791:CD4 Lymphocyte Count; D005260:Female; D005402:Fistula / Q000150:complications; D006801:Humans; D011241:Prednisone / Q000627:therapeutic use; D012002:Rectal Diseases / Q000150:complications; D013281:Stomatitis, Aphthous / Q000150:complications* / Q000188:drug therapy; D014623:Vaginal Diseases / Q000150:complications* / Q000188:drug therapy
chemical_list: D011241:Prednisone