title: Esophageal PCO2 as a monitor of perfusion failure during hemorrhagic shock.
abstract: Measurement of gastric wall PCO2 (PgCO2) by tonometric method has emerged as an attractive option for estimating visceral perfusion during circulatory shock. However, gastric acid secretion obfuscates the tonometric measurement. We, therefore, investigated the option of measuring PCO2 in the esophagus to minimize these restraints. Hemorrhagic shock was induced in five Sprague-Dawley rats, and five rats served as sham controls. PgCO2 was measured with an ion-sensitive field effect transistor that was surgically implanted into the gastric wall. Esophageal luminal PCO2 (PeCO2) was measured by a second ion-sensitive field effect transistor sensor. During hemorrhagic shock, mean aortic pressure declined from 150 to 50 mmHg. Gastric blood flow decreased from 58 to 12 ml.min-1.100 g-1 (21% of preshock) and esophageal blood flow from 44 to 7 ml.min-1.100 g-1 (16% of preshock). PgCO2 simultaneously increased from 47 to 116 Torr and PeCO2 from 47 to 127 Torr. The increases in PgCO2 were highly correlated with increases in PeCO2 (r = 0.90). Esophageal tonometry may, therefore, serve as a practical alternative to gastric tonometry.
authors.affiliation: Institute of Critical Care Medicine, Palm Springs 92262-5309, California.
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: M H
authors.initials: MH
authors.lastname: Weil
authors.forename: W
authors.initials: W
authors.lastname: Tang
authors.forename: S
authors.initials: S
authors.lastname: Sun
authors.forename: J
authors.initials: J
authors.lastname: Xie
authors.forename: J
authors.initials: J
authors.lastname: Bisera
authors.forename: H
authors.initials: H
authors.lastname: Hosaka
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism*; D004195:Disease Models, Animal; D004947:Esophagus / Q000503:physiopathology*; D006470:Hemorrhage / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012769:Shock / Q000503:physiopathology*
chemical_list: D002245:Carbon Dioxide