Isolation of two flavonoids from Tanacetum microphyllum as PMA-induced ear edema inhibitors.
The CH2Cl2 extract of Tanacetum microphyllum exhibited antiinflammatory activity on PMA-mouse ear model. Two antiinflammatory flavonoids, 5,7-dihydroxy-3,6,4'-trimethoxyflavone (santin) (1) and 5,7-dihydroxy-3,4'-dimethoxyflavone (ermanin) (2), were isolated.
Martinez
J
J
Department of Pharmacology, Faculty of Pharmacy, University Complutense, Madrid, Spain.
Silván
A M
AM
Abad
M J
MJ
Bermejo
P
P
Villar
A
A
Söllhuber
M
M
D000818:Animals; D004423:Ear / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D010944:Plants / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity*
D005419:Flavonoids; C104804:ermanin; C104803:santin; D013755:Tetradecanoylphorbol Acetate