Determination of amphetamine and methylenedioxy-amphetamine-derivatives in hair.
Two GC/MS-procedures for the detection of amphetamine and its methylenedioxy-derivatives (MDA, MDMA and MDE) in hair are presented. In these methods a methanol sonication extraction technique was applied. The extracted drugs were derivatized either with propionic acid anhydride (PSA) or trifluoroacetic acid anhydride (TFA). PSA-derivatives are more stable than TFA-derivatives, but the latter provide more specific mass-spectrometric information, and, therefore, seem to be preferably for amphetamine determination. The detection limit for all compounds was in a range of about 0.01 ng/mg, if at least 50-100 mg of hair were analyzed, independent of the derivatization used.
Röhrich
J
J
Zentrum der Rechtsmedizin, Johann Wolfgang Goethe-University Frankfurt, Germany.
Kauert
G
G
D015104:3,4-Methylenedioxyamphetamine / Q000032:analysis*; D000661:Amphetamine / Q000032:analysis*; D000697:Central Nervous System Stimulants / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D006197:Hair / Q000737:chemistry*; D006213:Hallucinogens / Q000032:analysis*; D006801:Humans; D015813:Substance Abuse Detection / Q000379:methods
D000697:Central Nervous System Stimulants; D006213:Hallucinogens; D015104:3,4-Methylenedioxyamphetamine; D000661:Amphetamine