Influence of gender and endogenous sex steroids on catecholaminergic structures involved in physiological adaptation to hypoxia.
Mechanisms underlying sex-related differences in adaptation to high altitude were investigated by assessing the turnover of dopamine and noradrenaline in structures of the chemoafferent pathway, i.e. carotid body and brainstem noradrenergic cell groups (A1, A5, A6, A2 to which chemosensory fibres project). The influence of gender was assessed in male and female rats reared at an altitude of 3600 m, whereas the influence of endogenous sex hormones was evaluated by castration. Haematocrit, red blood cell count and plasma erythropoietin levels were lower in females than in males (-5%, -15%, -53%, respectively). Dopamine and noradrenaline turnover were higher in female structures (carotid body: +51%; A2: +140%; A1: +54%; A5: +27%). Dopamine and noradrenaline turnover in carotid body and brainstem cell groups were differently affected by castration, i. e. enhanced by orchidectomy (carotid body: +134%; A2: +120%; A1: +69%; A5: +67%) but inhibited by ovariectomy (carotid body: -33%; A2: -92%). Orchidectomy elicited a reduction in haematocrit (-10%), haemoglobin concentration (-8%) and red blood cell count (-24%), whereas haematological status remained unaltered after ovariectomy. Therefore, both gender and endogenous sex steroids may control catecholamine activity differently in structures involved in the chemoafferent pathway, thus providing a neurochemical basis for sex-related differences in adaptation to hypoxia.
Pequignot
J M
JM
Unité Mixte de Recherche 5578, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon I, Laboratoire de Physiologie, 8 Avenue Rockefeller, F-69373 Lyon Cedex 08, France.
Spielvogel
H
H
Caceres
E
E
Rodriguez
A
A
Semporé
B
B
Pequignot
J
J
Favier
R
R
D000222:Adaptation, Physiological; D000818:Animals; D002628:Chemoreceptor Cells / Q000502:physiology; D004298:Dopamine / Q000502:physiology*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011941:Receptors, Adrenergic / Q000378:metabolism; D012727:Sex Characteristics
D012739:Gonadal Steroid Hormones; D011941:Receptors, Adrenergic; D004298:Dopamine; D009638:Norepinephrine