MLL cleavage occurs in approximately 5% of de novo acute myeloid leukemia, including in patients analyzed before treatment induction.
Macintyre
E
E
Bourquelot
P
P
Leboeuf
D
D
Rimokh
R
R
Archimbaud
E
E
Smetsers
T
T
Zittoun
R
R
D000208:Acute Disease; D002880:Chromosomes, Human, Pair 11; D053938:DNA Fragmentation; D004268:DNA-Binding Proteins / Q000235:genetics*; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy* / Q000235:genetics*; D051788:Myeloid-Lymphoid Leukemia Protein; D011519:Proto-Oncogenes; D012074:Remission Induction; D014157:Transcription Factors
D004268:DNA-Binding Proteins; C497422:KMT2A protein, human; D014157:Transcription Factors; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase