Integrin-ligand interactions: scratching the surface.
Integrins provide cells with critical means of communication with their microenvironments. By linking events at the cell surface to a dynamic cytoskeleton-signaling complex, integrins enable cells to rapidly modify their mechanical and genetic machinery in response to environmental cues. This review highlights major advances made in understanding the structural basis of integrin-ligand interactions and their regulation.
Kanazashi
S I
SI
Department of Medicine, Massachusetts General Hospital, Charleston, USA.
Sharma
C P
CP
Arnaout
M A
MA
D000818:Animals; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D008024:Ligands; D015398:Signal Transduction
D016023:Integrins; D008024:Ligands