Histone H4 mRNA from the nematode Ascaris lumbricoides is cis-spliced and polyadenylated.
A histone H4 gene from Ascaris lumbricoides contains an intron of approx. 2040 bp. Transcripts of the gene are spliced and polyadenylated. This is the first intron-containing H4 gene described for a metazoan. Notably, H4 mRNA from another nematode, Caenorhabditis elegans, is intron-less and lacks poly A (Roberts, S.B., Emmons, S.W. and Childs, G. (1989) J. Mol. Biol. 206, 567-577).
Wyler-Duda
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Abteilung für Entwicklungsbiologie, Universität Bern, Switzerland.
Bernard
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Stadler
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Suter
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Schümperli
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D
D000818:Animals; D017164:Ascaris lumbricoides / Q000235:genetics*; D017238:Genes, Helminth / Q000235:genetics; D006657:Histones / Q000235:genetics*; D007438:Introns / Q000235:genetics; D008969:Molecular Sequence Data; D011061:Poly A; D012326:RNA Splicing / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics*; D015183:Restriction Mapping; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
D006657:Histones; D012333:RNA, Messenger; D011061:Poly A