Anticipation of end-stage renal disease in autosomal dominant polycystic kidney disease.
Recently, anticipation of renal failure, i.e. earlier onset of end-stage renal disease in successive generations, has been reported in autosomal dominant polycystic kidney disease. In order to evaluate differences in length of time in reaching end-stage renal disease, we examined 55 families with accurate information about renal death. In 12 families the average difference between the age at renal death in 17 parent-offspring pairs was 7.7 years (range from -5 to 22 years). This value was significantly greater than zero (P = 0.0004). Thus, a substantial decrease in the age at renal death in the offspring as compared with the parent has been observed in this group of families.
Gonzalo
A
A
Servicio de Nefrologia, Hospital Ramon y Cajal, Madrid, Spain.
Gallego
A
A
San Millan
J L
JL
Ortuño
J
J
D017668:Age of Onset; D000368:Aged; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications* / Q000235:genetics