title: Histologic differences between flat tubular colorectal neoplasias in Japan and Sweden.
abstract: A total of 231 flat colorectal neoplasias were investigated at two disparate geographical regions (Stockholm and Tokyo). Of the 141 flat neoplasias seen in Tokyo, 24.8% had HGD, 7.0% intramucosal carcinoma and 9.9% invasive carcinoma. On the other hand, of the 90 flat mucosal neoplasias seen in Stockholm, 13.3% had HGD, 1.1% intramucosal carcinoma and 1.1% invasive carcinoma. The differences between flat adenomas with HGD, intramucosal carcinomas and invasive carcinomas in Japanese patients were significantly higher (p < 0.001) than in Swedish patients. While the causes responsible for this geographic difference remains unclear, possible influences of ethnicity and/or of environmental factors were advanced.
authors.affiliation: Department of Pathology, Karolinska Institute and Hospital, Stockholm, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Rubio
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Masaki
authors.forename: T
authors.initials: T
authors.lastname: Muto
mesh_terms: D000236:Adenoma / Q000473:pathology*; D002277:Carcinoma / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000473:pathology*; D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D007564:Japan; D009361:Neoplasm Invasiveness; D013548:Sweden