Genetic analysis of a meningococcal population based on polymorphism of the pilA-pilB locus: a molecular approach for meningococcal epidemiology.
The genetic relationships between 88 meningococcal strains were analyzed by using the polymorphism of the pilA gene and the multilocus enzyme electrophoresis. While a good agreement was observed, correlation with antigenic formula (serogroup, serotype, and serosubtype) was incomplete. The inadequacy of serological classification alone in outbreak surveillance may be overcome by DNA-based approaches.
Guibourdenche
M
M
Unité des Neisseria, Institut Pasteur, Paris, France.
Giorgini
D
D
Guèye
A
A
Larribe
M
M
Riou
J Y
JY
Taha
M K
MK
D000483:Alleles; D001426:Bacterial Proteins / Q000235:genetics; D015373:Bacterial Typing Techniques; D004268:DNA-Binding Proteins / Q000235:genetics; D004196:Disease Outbreaks; D036781:Fimbriae Proteins; D005798:Genes, Bacterial; D006801:Humans; D008589:Meningococcal Infections / Q000453:epidemiology / Q000382:microbiology; D017720:Molecular Epidemiology; D009345:Neisseria meningitidis / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D010088:Oxidoreductases; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012703:Serotyping
D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D036781:Fimbriae Proteins; D010088:Oxidoreductases; C068255:pilB protein, Bacteria