title: Changes in gene expression for skin-type fatty acid binding protein in hypoglossal motor neurons following nerve crush.
abstract: The changeability in the gene expression for five species of fatty acid binding protein (FABP) was investigated in the crushed hypoglossal nucleus by in situ hybridization histochemistry. Increased gene expression for skin-type fatty acid binding protein (S-FABP) was evident in the affected hypoglossal neurons on the 3rd day after nerve crush, and it lasted until the postoperative day 14. On the other hand, no significant gene expression for heart-, liver-, intestinal- or brain-type FABPs was detected in the hypoglossal neurons of normal control or in these neurons for 3 weeks after the nerve crush. These findings suggest that skin-type FABP may selectively contribute to some important roles in morphological and biochemical changes of neuronal cells associated with the nerve regeneration.
authors.affiliation: Department of Anatomy, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Owada
authors.forename: A
authors.initials: A
authors.lastname: Utsunomiya
authors.forename: T
authors.initials: T
authors.lastname: Yoshimoto
authors.forename: H
authors.initials: H
authors.lastname: Kondo
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids / Q000378:metabolism; D015870:Gene Expression; D007002:Hypoglossal Nerve / Q000473:pathology / Q000502:physiology*; D017403:In Situ Hybridization; D008297:Male; D008473:Median Eminence / Q000473:pathology / Q000502:physiology*; D018996:Myelin P2 Protein / Q000235:genetics*; D009363:Neoplasm Proteins; D009409:Nerve Crush; D009419:Nerve Tissue Proteins; D009474:Neurons / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D012879:Skin Physiological Phenomena
chemical_list: D002352:Carrier Proteins; C490174:Fabp7 protein, rat; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D018996:Myelin P2 Protein; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins