title: Genes of the membrane-type matrix metalloproteinase (MT-MMP) gene family, MMP14, MMP15, and MMP16, localize to human chromosomes 14, 16, and 8, respectively.
abstract: The membrane-type matrix metalloproteinases (MT-MMPs) constitute a newly discovered family of four enzymes within the matrix metalloproteinase (MMP) superfamily. We have mapped the genes for MT1-MMP (MMP14), MT2-MMP (MMP15), and MT3-MMP (MMP16) using in situ hybridization to human metaphase chromosomes. In contrast to the genes for many MMPs that are clustered on chromosome 11, the genes MMP14, MMP15, and MMP16 all map to distinct chromosomes. MMP14 maps to human chromosome 14, MMP15 to human chromosome 16, and MMP16 to human chromosome 8.
authors.affiliation: Hospital d'Enfants, INSERM U406, Groupe Hospitalier de la Timone, Marseille, France.
authors.forename: M G
authors.initials: MG
authors.lastname: Mattei
authors.forename: N
authors.initials: N
authors.lastname: Roeckel
authors.forename: B R
authors.initials: BR
authors.lastname: Olsen
authors.forename: S S
authors.initials: SS
authors.lastname: Apte
mesh_terms: D002478:Cells, Cultured; D002883:Chromosomes, Human, Pair 14; D002885:Chromosomes, Human, Pair 16; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D053511:Matrix Metalloproteinase 14; D053517:Matrix Metalloproteinase 15; D053513:Matrix Metalloproteinase 16; D053504:Matrix Metalloproteinases, Membrane-Associated; D008666:Metalloendopeptidases / Q000235:genetics*
chemical_list: C507098:MMP15 protein, human; C507102:MMP16 protein, human; D053517:Matrix Metalloproteinase 15; D053513:Matrix Metalloproteinase 16; D053504:Matrix Metalloproteinases, Membrane-Associated; D008666:Metalloendopeptidases; C507086:MMP14 protein, human; D053511:Matrix Metalloproteinase 14