Changes in taurine levels in response to repeated administration of the beta 2-agonist salbutamol in lambs.
Repeated oral administration of salbutamol to lambs for 28 days was found to decrease levels of taurine significantly in the serum and heart, and the mean excretion of taurine into urine was significantly less than in controls. Serum urea, low density lipoprotein and high density lipoprotein were also significantly reduced. Consistent with these changes, fat content in muscle was reduced, whereas protein content was not significantly changed. Body weight was not significantly changed by salbutamol treatment but heart and kidney weights (relative to body weight) were significantly increased. Salbutamol excretion in urine was relatively constant and residues were detected in certain organs and tissues, notably liver, bile and kidney. Changes in urinary and serum taurine level may reflect subtle changes in protein metabolism not detectable as changes in body weight or gross protein content.
Bastos
M L
ML
CEQUP/Toxicology Laboratory, Faculty of Pharmacy, Porto University, Portugal.
Carvalho
F
F
Remião
F
F
Mendes
M E
ME
Ferreira
M A
MA
Soares
M E
ME
Timbrell
J A
JA
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000284:Administration, Oral; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D000420:Albuterol / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D005123:Eye / Q000187:drug effects / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D009124:Muscle Proteins / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D011897:Random Allocation; D012756:Sheep / Q000378:metabolism*; D013654:Taurine / Q000097:blood / Q000378:metabolism* / Q000652:urine; D014018:Tissue Distribution; D014132:Trachea / Q000187:drug effects / Q000378:metabolism; D014508:Urea / Q000097:blood
D000318:Adrenergic beta-Agonists; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D009124:Muscle Proteins; D013654:Taurine; D014508:Urea; D000420:Albuterol