Chronopharmacology of etoposide given by low dose prolonged infusion in lung cancer patients.
We examined the chronopharmacology of prolonged etoposide administration by intravenous infusion over 14 days in 9 patients with lung cancer. Blood samples were obtained every 4 hours between 24 hours and 48 hours after initiation of the infusion. Using the unpaired t-test, the percentage plasma etoposide concentration at 09:00 hours calculated from the 24 hour average value, was significantly higher than that at 21:00 hours (p = 0.024). However, neither ANOVA nor cosinor analysis revealed any significant effect of sampling time (ANOVA: p = 0.29, cosinor analysis: p = 0.46).
Yamamoto
N
N
Department of Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.
Tamura
T
T
Ohe
Y
Y
Oshita
F
F
Kasai
T
T
Kurata
T
T
Shinkai
T
T
Eguchi
K
K
Saijo
N
N
D000328:Adult; D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D019454:Chronotherapy; D005047:Etoposide / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging
D000972:Antineoplastic Agents, Phytogenic; D005047:Etoposide