Long-term therapeutic effects of ace inhibitor and calcium antagonists on hypertensive vascular lesions in M-SHRSP.
1. Our results indicate that the drugs used in this study are very effective in malignant hypertension therapy. 2. For M-SHRSP treated with highly effective antihypertensive drugs, if blood pressure remains under 200 mmHg over the long-term, the structures of the small arteries and/or arterioles stay as well preserved as they do in WKY. 3. For M-SHRSP treated with drugs with a lower antihypertensive effect, the occurrence of cerebrovascular lesions and angionecrosis in the various organs are suppressed significantly, even though blood pressure remains over 250 mmHg over the long-term. Based upon effect alone, there is no difference between ACEI and a calcium antagonist. However, inhibition of the proliferation of vascular smooth muscle cells is more potent in the former than in the latter. 4. These results suggest that ACEI might have the potential to suppress smooth muscle cell proliferation independent of high blood pressure.
Ohta
Y
Y
Department of Pathology, Kinki University School of Medicine, Ohno-Higashi, Osaka-Sayama, Japan.
Chikugo
T
T
Suzuki
T
T
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001808:Blood Vessels / Q000473:pathology*; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002455:Cell Division / Q000502:physiology; D002561:Cerebrovascular Disorders / Q000235:genetics / Q000473:pathology; D006974:Hypertension, Malignant / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology*; D008297:Male; D009336:Necrosis; D051381:Rats; D011918:Rats, Inbred SHR
D000806:Angiotensin-Converting Enzyme Inhibitors; D002121:Calcium Channel Blockers