title: misshapen encodes a protein kinase involved in cell shape control in Drosophila.
abstract: We have identified a novel protein kinase encoded by the misshapen gene, which is required for the normal shape and orientation of Drosophila photoreceptor cells. misshapen is also expressed in the embryonic mesoderm, pole plasm and other sites of cell shape change or movement. We propose that msn may act in a signal transduction pathway leading to cytoskeletal re-arrangements.
authors.affiliation: MCB and HHMI, University of California at Berkeley 94704, USA. treisman@saturn.med.nyu.edu
authors.forename: J E
authors.initials: JE
authors.lastname: Treisman
authors.forename: N
authors.initials: N
authors.lastname: Ito
authors.forename: G M
authors.initials: GM
authors.lastname: Rubin
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002465:Cell Movement / Q000235:genetics*; D004330:Drosophila / Q000196:embryology* / Q000235:genetics*; D004625:Embryo, Nonmammalian / Q000166:cytology; D005314:Embryonic and Fetal Development / Q000235:genetics; D005123:Eye / Q000196:embryology* / Q000473:pathology; D018507:Gene Expression Regulation, Developmental; D008969:Molecular Sequence Data; D017956:Photoreceptor Cells, Invertebrate / Q000473:pathology; D011494:Protein Kinases / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D014158:Transcription, Genetic
chemical_list: D011494:Protein Kinases