Effects of lutein from marigold extract on immunity and growth of mammary tumors in mice.
The effects of dietary lutein from marigold extract on the development and growth of a transplantable murine mammary tumor and on lymphocyte function were investigated. Mice were fed a diet containing 0.1% or 0.4% of lutein. In experiment 1, mice were fed the diets for 3 weeks and infused with mammary tumor cells into the mammary gland. Dietary lutein increased tumor latency and inhibited mammary tumor growth in a dose-dependent manner. The incidence of palpable tumors on day 28 post-infusion and final tumor weight were lower in mice fed lutein. In experiment 2, dietary lutein enhanced phytohemagglutinin-induced lymphocyte proliferation but had no effect on interleukin-2 production or lymphocyte cytotoxicity. Therefore dietary lutein increased tumor latency, suppressed mammary tumor growth and enhanced lymphocyte proliferation.
Chew
B P
BP
Department of Animal Sciences, Washington State University, Pullman 99164-6320, USA.
Wong
M W
MW
Wong
T S
TS
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D005260:Female; D007111:Immunity, Cellular; D014975:Lutein / Q000097:blood / Q000494:pharmacology* / Q000600:supply & distribution; D008213:Lymphocyte Activation; D008325:Mammary Neoplasms, Experimental / Q000097:blood / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D010936:Plant Extracts; D014975:Lutein