[The membrane hetero-organic antigens of tumors of hepatocellular and myogenic origins].
Cell-surface antigens of some tumors and homologous definitive tissues were investigated with organospecific immunoserum against rat kidney membranes using methods of immunofluorescence and enzyme immunoassay. Myogenic cells were also tested to resolve the role of the membrane hetero-organic antigens in the process of proliferation. Membrane hetero-organic antigens, commonly attributed to definitive kidney tissue, were found on the cell surface of rat rhabdomyosarcoma RA-2 and cultured cells of rat hepatomas HTC and 27. However, hetero-organic antigens on the surface of active proliferating myogenic cells were not found. It is concluded that membrane hetero-organic antigens, usually attributed to definitive kidney tissue, represent one of characteristic manifestations of neoplastic cell transformation rather than results of intensive proliferation of the cells.
Teriukova
N P
NP
Tiuriaeva
I I
II
Grandilevskaia
A B
AB
Ivanov
V A
VA
D000818:Animals; D015478:Antigens, Heterophile / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000276:immunology; D002478:Cells, Cultured; D005347:Fibroblasts / Q000276:immunology; D019084:Fluorescent Antibody Technique, Indirect; D007124:Immunoenzyme Techniques; D007668:Kidney / Q000166:cytology / Q000276:immunology; D008114:Liver Neoplasms, Experimental / Q000276:immunology*; D051379:Mice; D009132:Muscles / Q000166:cytology / Q000276:immunology; D009368:Neoplasm Transplantation; D051381:Rats; D012208:Rhabdomyosarcoma / Q000276:immunology*; D014407:Tumor Cells, Cultured
D015478:Antigens, Heterophile; D000951:Antigens, Neoplasm; D000954:Antigens, Surface
Membrannye geteroorgannye antigeny opukholeĭ gepatotselliuliarnogo i miogennogo proiskhozhdeniia.