title: The genomic structure of a mouse seminal vesicle autoantigen.
abstract: The genomic structure of an androgen-stimulated mouse seminal vesicle autoantigen was determined. Analysis of the nucleotide sequence established 2135 bp of the 5'-flanking region, four exons of 123, 136, 112, 227 bp, three introns of 1555, 1931, 316 bp, and 185 bp of the 3'-flanking region of this gene. Ten DNA segments, five in the 5'-flanking region, two in the first intron, and three in the second intron were identified to have more than 50% homology with the consensus sequence of the androgen response element (ARE). Two sets of adjacent DNA segments, one including -213 to -199 bp and -124 to -110 bp in the 5'-flanking region and the other including 2532 to 2546 bp and 2582 to 2596 bp in the second intron, are noticeable for their high degree of homology with ARE.
authors.affiliation: Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan.
authors.forename: L C
authors.initials: LC
authors.lastname: Yu
authors.forename: Y L
authors.initials: YL
authors.lastname: Hsiao
authors.forename: Y H
authors.initials: YH
authors.lastname: Yang
authors.forename: M
authors.initials: M
authors.lastname: Lin
authors.forename: Y H
authors.initials: YH
authors.lastname: Chen
mesh_terms: D000728:Androgens / Q000494:pharmacology; D000818:Animals; D001324:Autoantigens / Q000235:genetics*; D001483:Base Sequence; D016384:Consensus Sequence; D005091:Exons; D005796:Genes; D015698:Genomic Library; D007438:Introns; D051379:Mice; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D012045:Regulatory Sequences, Nucleic Acid; D029607:Seminal Vesicle Secretory Proteins; D014158:Transcription, Genetic
chemical_list: D000728:Androgens; D001324:Autoantigens; D029607:Seminal Vesicle Secretory Proteins; C085073:seminal vesicle autoantigen