[Why do tumors metastasize and why to the lung or liver?].
Biological alterations of tumor cells which lead to metastasizing properties can now be identified in some cases in specific molecules (adhesion molecules, proteases, cytoskeleton, angiogenesis factors). To explain organ-specific metastasis, organ-specific mechanisms of adhesion to endothelial and parenchymal cells have been in the forefront for two decades. Based primarily, but not exclusively, on animal models, we must include more and more paracrine growth factors produced by the target organ, including the lung.
Burger
M M
MM
Friedrich-Miescher-Institut, Basel.
D043925:Angiogenesis Inducing Agents / Q000502:physiology; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D010450:Endopeptidases / Q000096:biosynthesis; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary*; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary*; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis / Q000473:pathology* / Q000503:physiopathology; D009928:Organ Specificity
D043925:Angiogenesis Inducing Agents; D015815:Cell Adhesion Molecules; D010450:Endopeptidases
Weshalb metastasiert ein Malignom und weshalb in die Lunge oder die Leber?