Transcription factors vs nucleosomes: regulation of the PHO5 promoter in yeast.
Activation of the Saccharomyces cerevisiae PHO5 gene is accompanied by the disruption of four positioned nucleosomes at the promoter. The chromatin transition requires a DNA-binding protein, Pho4, and its transactivation domain. The mechanism of nucleosome disruption and the contribution of the nucleosomes to PHO5 regulation are reviewed.
Svaren
J
J
Department of Pathology, Washington University School of Medicine, St Louis, MO 63110-1093, USA.
Hörz
W
W
D002843:Chromatin / Q000737:chemistry / Q000378:metabolism / Q000648:ultrastructure; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D026901:Membrane Transport Proteins / Q000235:genetics*; D009707:Nucleosomes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D028061:Phosphate Transport Proteins; D011401:Promoter Regions, Genetic; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D026901:Membrane Transport Proteins; D009707:Nucleosomes; D028061:Phosphate Transport Proteins; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; C055831:phosphate permease; C069938:SPT2 protein, S cerevisiae