title: A report on 158 cases of transcervical chorionic villus sampling.
abstract: Between 1989 and 1994 first trimester transcervical chorionic villus sampling was offered to 158 patients after proper counselling. The gestational age range was 9-12 weeks. The most important indication was advanced maternal age (75.4%). Adequate sampling after two, and a maximum of three attempts, was achieved in 98% and 99.3% of patients respectively. After the first year of the study karyotyping using the direct method alone was successful in 96% of cases. The success of karyotyping cultures was 98%. Excluding one false positive result the rate of fetal karyotypic abnormalities was 4.8%. 5 spontaneous abortions occurred (3.2%), all in patients of advanced maternal age. Moderate or severe vaginal bleeding occurred in 6.7% of the patients. There was no case of chorioamnionitis.
authors.affiliation: Department of Obstetrics and Gynecology, University of Saarland, Homburg/Saar, Germany.
authors.forename: H M
authors.initials: HM
authors.lastname: Salihu
authors.forename: R
authors.initials: R
authors.lastname: Boos
authors.forename: W
authors.initials: W
authors.lastname: Schmidt
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D000328:Adult; D002584:Cervix Uteri; D015193:Chorionic Villi Sampling / Q000009:adverse effects*; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D008423:Maternal Age; D011247:Pregnancy; D018566:Pregnancy, High-Risk; D014592:Uterine Hemorrhage / Q000209:etiology