Prognostic value of histologic findings in neck dissections for squamous cell carcinoma.
BACKGROUND
Cervical node involvement is the most significant prognostic factor in head and neck squamous cell carcinoma. When histologic findings show node invasion, the number of positive nodes and the presence of extracapsular spread are commonly accepted as prognostic factors.


OBJECTIVE
To confirm the findings of recent reports that there is no significant difference in outcome associated with extracapsular spread.


METHODS
Referral center.


METHODS
Retrospective study.


METHODS
Three hundred thirty-seven patients under-going 487 neck dissections for carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx from January 1, 1985, to December 31, 1992. For N3 node involvement, a radical neck dissection was performed; other patients underwent supraomohyoid or functional neck dissection. Two hundred forty-two patients underwent postoperative radiotherapy (mean dose, 59 Gy).


METHODS
Survival capabilities calculated by the Kaplan-Meier method and significance calculated by the log rank test.


RESULTS
Overall 5-year survival was 50.8%. The study of prognostic factors showed no significance for extracapsular spread (P = 45). Conversely, the number of positive nodes had a significant value (P < .001).


CONCLUSIONS
Extracapsular node spread per se might be considered as no longer having a definitive prognostic value. These results, consistent with those of previous reports, may be due to wider use of combined treatment modalities.
Pinsolle
J
J
Department of Maxillofacial and Plastic Surgery, Centre Hospitalier Universitaire de Bordeaux, France.
Pinsolle
V
V
Majoufre
C
C
Duroux
S
S
Demeaux
H
H
Siberchicot
F
F
D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology / Q000556:secondary; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009367:Neoplasm Staging; D011182:Postoperative Care; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D015996:Survival Rate