title: Protective effects of acidic fibroblast growth factor against cardiac arrhythmias induced by ischemia and reperfusion in rats.
abstract: An in vivo study has been conducted to evaluate the effect of acidic fibroblast growth factor (aFGF) on cardiac arrhythmias which occur in transient myocardial ischemia followed by reperfusion. In a rat model of myocardial ischemia and reperfusion, cardiac arrhythmias were assessed during the first three minutes of reperfusion. Systemic administration of 2.6 micrograms aFGF just before coronary recirculation resulted in a significant reduction in incidence and severity of ventricular extra beats (VEBs), ventricular tachycardia (VT) and ventricular fibrillation (VF), compared with control rats (VT incidence: 30% vs 80%, VF incidence: 10% vs 40%; episodes of VT: 4.1 +/- 0.34 vs 8.8 +/- 0.95; episodes of VF: 4.8 +/- 0.32 vs 11.5 +/- 1.47). Our results suggest a novel role for FGFs as potential antiarrhythmic agents.
authors.affiliation: Servicio de Histología, Hospital Ramón y Cajal, Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Cuevas
authors.forename: F
authors.initials: F
authors.lastname: Carceller
authors.forename: A
authors.initials: A
authors.lastname: Hernández-Madrid
authors.forename: B
authors.initials: B
authors.lastname: Cuevas
authors.forename: V
authors.initials: V
authors.lastname: Martínez-Coso
authors.forename: G
authors.initials: G
authors.lastname: Giménez-Gallego
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*; D003326:Coronary Circulation / Q000187:drug effects; D016220:Fibroblast Growth Factor 1 / Q000494:pharmacology*; D006801:Humans; D015994:Incidence; D017202:Myocardial Ischemia / Q000503:physiopathology*; D015425:Myocardial Reperfusion; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000627:therapeutic use; D017180:Tachycardia, Ventricular / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D013997:Time Factors; D014693:Ventricular Fibrillation / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control
chemical_list: D011994:Recombinant Proteins; D016220:Fibroblast Growth Factor 1