title: Kainic acid-induced sprouting of dynorphin- and enkephalin-containing mossy fibers in the dentate gyrus of the rat hippocampus.
abstract: This study utilized Timm histochemistry and immunocytochemistry to determine the prolonged effects of kainic acid on the distribution of dynorphin- and enkephalin-containing mossy fibers in the rat dentate gyrus at progressive time points following kainic acid injection. Beginning 1-2 weeks after kainic acid administration, a progressive increase in the distribution and intensity of staining for supragranular zinc, dynorphin and enkephalin was observed in the dentate gyrus. The kainic acid-induced sprouting of mossy fibers containing dynorphin and enkephalin strongly resembles the pattern observed in the dentate gyrus of humans with temporal lobe epilepsy.
authors.affiliation: The Curriculum in Neurobiology, University of North Carolina, Chapel Hill 27599, USA.
authors.forename: J N
authors.initials: JN
authors.lastname: Simpson
authors.forename: W Q
authors.initials: WQ
authors.lastname: Zhang
authors.forename: G
authors.initials: G
authors.lastname: Bing
authors.forename: J S
authors.initials: JS
authors.lastname: Hong
mesh_terms: D000818:Animals; D018891:Dentate Gyrus / Q000737:chemistry / Q000187:drug effects* / Q000648:ultrastructure; D004399:Dynorphins / Q000032:analysis*; D004745:Enkephalins / Q000032:analysis*; D007150:Immunohistochemistry; D007279:Injections, Subcutaneous; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D009412:Nerve Fibers / Q000737:chemistry / Q000187:drug effects*; D051381:Rats; D011916:Rats, Inbred F344; D013194:Staining and Labeling
chemical_list: D004745:Enkephalins; D004399:Dynorphins; D007608:Kainic Acid