title: Long-term comparison of antireflux surgery versus conservative therapy for reflux esophagitis.
abstract: OBJECTIVE
  The purpose of the study was to evaluate the long-term symptomatic and endoscopic outcome in gastroesophageal reflux disease with erosive esophagitis, comparing conservative with operative management.
  
  
  METHODS
  The study comprised 105 of 120 patients consecutively referred for severe reflux symptoms to the gastroenterologic outpatient department of a teaching hospital, where erosive esophagitis was confirmed endoscopically. If conservative management (modified lifestyle and medication) failed to relieve symptoms and heal the esophagitis, antireflux surgery (Nissen fundoplication) was undertaken. Follow-up (median, 10.9 years) evaluation of all patients included comprehensive, standardized interviews; self-scoring of symptoms at the time of referral and currently; and observations at endoscopy.
  
  
  RESULTS
  Nissen fundoplication was performed on 37 of the 105 patients. At follow-up of these 37 patients, (31) 84% had no or only occasional mild heartburn, (33) 89% were free from erosive esophagitis, and (2) 5% were taking H2 antagonists or omeprazole. The corresponding figures in the 68 patients with only conservative treatment were (36) 53%, (31) 45%, and (14) 21%. The mean change in symptom score between referral time and follow-up was 5.7 in the surgically treated group and 1.7 in the nonsurgically treated group. Fifteen new cases of Barrett's metaplasia were found at follow-up.
  
  
  CONCLUSIONS
  In gastroesophageal reflux disease with erosive esophagitis, surgical treatment gave results subjectively and objectively superior to those from conservative management.
authors.affiliation: Department of Surgery, School of Medicine, University of Tampere, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Isolauri
authors.forename: M
authors.initials: M
authors.lastname: Luostarinen
authors.forename: M
authors.initials: M
authors.lastname: Viljakka
authors.forename: E
authors.initials: E
authors.lastname: Isolauri
authors.forename: O
authors.initials: O
authors.lastname: Keyriläinen
authors.forename: A L
authors.initials: AL
authors.lastname: Karvonen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004942:Esophagitis, Peptic / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors