title: Serum carcinoembryonic antigen concentration doubling time correlates with tumor biology and life expectancy in patients with recurrent gastrointestinal carcinoma.
abstract: OBJECTIVE
  To determine if carcinoembryonic antigen (CEA) concentration doubling time (DT) can predict the course of disease and characterize tumor biology.
  
  
  METHODS
  Retrospective case series of patients who exhibited a distinct increase in circulating CEA during disease recurrence in the routine postoperative follow-up.
  
  
  METHODS
  A tertiary general hospital.
  
  
  METHODS
  Twenty patients with recurrent gastric carcinoma and 17 patients with recurrent colorectal carcinoma.
  
  
  METHODS
  The CEA DT was determined from semilogarithmic plots of CEA concentration time courses.
  
  
  METHODS
  The quantitative analyses of the CEA DT as related to various host and tumor characteristics, modes of recurrence, and life expectancy.
  
  
  RESULTS
  The mean CEA DTs for gastric and colorectal carcinomas were 229 days and 86 days, respectively. Although there were no significant differences with regard to patient age, tumor size, gross appearance, and histological differentiation, women had shorter CEA DT than did men. Flow cytometric analysis showed that tumors with a higher proportion of cells in S phase (> or = 15%) had significantly shorter CEA DT than those with a lower S-phase fraction (< 15%). There was a significant correlation between the CEA DT and the length of survival after the initial CEA concentration increase in patients with recurrent gastric and colorectal carcinomas. In the multiple regression analysis of patients who had been treated with curative surgery and chemotherapy, CEA DT proved to be a major independent prognostic factor.
  
  
  CONCLUSIONS
  Carcinoembryonic antigen DT predicts life expectancy in patients with adenocarcinoma of the gastrointestinal tract. Differences in survival time are closely associated with variations in the biological aggressiveness of individual tumors.
authors.affiliation: Department of Surgery, Fukuoka City Hospital, Japan.
authors.forename: D
authors.initials: D
authors.lastname: Korenaga
authors.forename: H
authors.initials: H
authors.lastname: Saeki
authors.forename: K
authors.initials: K
authors.lastname: Mawatari
authors.forename: H
authors.initials: H
authors.lastname: Orita
authors.forename: S
authors.initials: S
authors.lastname: Maekawa
authors.forename: T
authors.initials: T
authors.lastname: Ikeda
authors.forename: K
authors.initials: K
authors.lastname: Sugimachi
mesh_terms: D000328:Adult; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000401:mortality; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000097:blood* / Q000401:mortality; D006801:Humans; D008017:Life Expectancy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors
chemical_list: D002272:Carcinoembryonic Antigen