Mycoplasma fermentans enhances concanavalin A-induced apoptosis of mouse splenic T cells.
Mycoplasma fermentans, an AIDS-associated mycoplasma, possessed the activity of enhancing concanavalin A-induced apoptosis of T cells purified from mouse spleen by a nylon wool column, and tumor necrosis factor-alpha played an important role in expression of the activity. M. salivarium, an oral mycoplasma, used for comparative purposes also possessed the activity, the level of which was lower than that of M. fermentans.
Shibata
K
K
Department of Oral Bacteriology, Hokkaido University School of Dentistry, Sapporo, Japan. shibaken@den.hokudai.ac.jp
Watanabe
T
T
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001425:Bacterial Outer Membrane Proteins / Q000494:pharmacology; D003208:Concanavalin A / Q000494:pharmacology*; D005434:Flow Cytometry; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D016858:Mycoplasma fermentans / Q000502:physiology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000382:microbiology*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D001425:Bacterial Outer Membrane Proteins; D014409:Tumor Necrosis Factor-alpha; D003208:Concanavalin A