Serum glutathione S-transferase concentrations and creatinine clearance after sevoflurane anaesthesia.
The effects of sevoflurane and isoflurane on serum glutathione S-transferase concentrations and creatinine clearance were compared in 50 ASA I-III patients aged over 18 years undergoing body surface surgery of 1-3 h predicted duration. Patients randomly received sevoflurane (n = 24) or isoflurane (n = 26) in nitrous oxide and oxygen (FIO2 = 0.4) via a nonrebreathing system. Fluids were standardised and patient's lungs ventilated to normocapnia. Expired concentration of anaesthetic agent was adjusted to maintain systolic arterial pressure between 70 and 100% of baseline. Patients received significantly less (p < 0.05) sevoflurane (1.0 MAC-h) than isoflurane (1.5 MAC-h). Using serum glutathione S-transferase concentrations and creatinine clearance as markers of hepatic and renal function respectively, no statistically significant differences were identified between the groups.
Darling
J R
JR
Department of Anaesthesia, Ulster Hospital, Belfast, UK.
Murray
J M
JM
McBride
D R
DR
Trinick
T R
TR
Fee
J P
JP
D000328:Adult; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000378:metabolism*; D004987:Ethers / Q000494:pharmacology*; D005260:Female; D005982:Glutathione Transferase / Q000097:blood* / Q000187:drug effects; D006801:Humans; D007530:Isoflurane / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D008099:Liver / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D008738:Methyl Ethers; D008875:Middle Aged; D011184:Postoperative Period; D000077149:Sevoflurane
D018685:Anesthetics, Inhalation; D015415:Biomarkers; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D003404:Creatinine; D007530:Isoflurane; D005982:Glutathione Transferase