title: Blue toe syndrome associated with rapidly progressive glomerulonephritis: ultimately revealed essential mixed cryoglobulinemia.
abstract: The blue toe syndrome is a rare presentation in a number of medical disorders. We report a 35-year-old woman who initially presented with blue toe syndrome and rapidly progressive glomerulonephritis. Essential mixed cryoglobulinemia with vasculitis and renal failure was documented by laboratory tests and renal biopsy. She was on maintenance hemodialysis as renal failure persisted after steroid and immunosuppressive agents therapy. Her gangrenous changes of bilateral toes were autoamputated symmetrically and uneventfully.
authors.affiliation: Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung Medical and Technological College, Taipei, Taiwan, Republic of China.
authors.forename: J T
authors.initials: JT
authors.lastname: Fang
authors.forename: C C
authors.initials: CC
authors.lastname: Huang
mesh_terms: D000328:Adult; D000671:Amputation, Surgical; D001706:Biopsy; D018438:Blue Toe Syndrome / Q000150:complications* / Q000473:pathology / Q000601:surgery; D003449:Cryoglobulinemia / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D018450:Disease Progression; D005260:Female; D005921:Glomerulonephritis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D051437:Renal Insufficiency / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D012867:Skin / Q000473:pathology; D014657:Vasculitis / Q000150:complications / Q000473:pathology
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents