The 1996 Massry Prize. Inositol trisphosphate and calcium: two interacting second messengers.
Inositol trisphosphate (InsP3) functions as a second messenger to control the release of internal calcium and the entry of external calcium. This InsP3/Ca2+ signalling pathway is based on a hierachical system with the release from individual channels being the fundamental event (Ca2+ blips). A collection of blips produces larger elementary events (Ca2+ puffs) which then fuse through a regenerative process of calcium-induced calcium release to give global events (Ca2+ waves). This highly versatile signalling system has been adapted to regulate a wide range of cellular processes including fertilization, development, proliferation and apoptosis.
Berridge
M J
MJ
Babraham Institute Laboratory of Molecular Signalling, Cambridge, UK. mjb38@cus.cam.ac.uk
D000818:Animals; D017209:Apoptosis; D001363:Awards and Prizes; D002118:Calcium / Q000502:physiology*; D015220:Calcium Channels / Q000378:metabolism; D002455:Cell Division; D005306:Fertilization; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000502:physiology*; D007313:Insecta / Q000378:metabolism; D009398:Nephrology; D012469:Salivary Glands / Q000378:metabolism; D015290:Second Messenger Systems
D015220:Calcium Channels; D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium