Dietary vitamin K1 and stability of oral anticoagulation: proposal of a diet with constant vitamin K1 content.
Case reports cited in Medline or Biological Abstracts (1966-1996) were reviewed to evaluate the impact of vitamin K1 dietary intake on the stability of anticoagulant control in patients using coumarin derivatives. Reported nutrient-drug interactions cannot always be explained by the vitamin K1 content of the food items. However, metabolic data indicate that a consistent dietary intake of vitamin K is important to attain a daily equilibrium in vitamin K status. We report a diet that provides a stable intake of vitamin K1 equivalent to the current U.S. Recommended Dietary Allowance, using food composition data derived from high-performance liquid chromatography. Inconsistencies in the published literature indicate that prospective clinical studies should be undertaken to clarify the putative dietary vitamin K1-coumarin interaction. The dietary guidelines reported here may be used in such studies.
Booth
S L
SL
Jean Mayer USDA Human Nutrition Center on Aging, Tufts University, Boston, MA 02111, USA.
Charnley
J M
JM
Sadowski
J A
JA
Saltzman
E
E
Bovill
E G
EG
Cushman
M
M
D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003374:Coumarins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004032:Diet; D004347:Drug Interactions; D006801:Humans; D009752:Nutritional Status; D010837:Vitamin K 1 / Q000494:pharmacology*; D014859:Warfarin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use
D000925:Anticoagulants; D003374:Coumarins; D014859:Warfarin; D010837:Vitamin K 1