title: Ewing's sarcoma of the femur. Prognosis in 69 patients treated by the CESS group.
abstract: We reviewed the treatment outcome of 69 patients with Ewing's sarcoma of the femur. The patients received chemotherapy according to the CESS 81 (n 14), CESS 86 (n 43), and CESS 91P (n 12) protocols. The 10-year relapse-free survival rates were 36%, 65%, and 65% (p = 0.01). 68 patients received local treatment. The primary tumor was treated by surgery without radiotherapy in 28 patients; 1 developed a local recurrence and 7 metastases. 10 patients received radiotherapy alone; 4 developed metastases and 4 local recurrences and metastases. 30 cases had a combination of surgery and radiotherapy; 7 developed metastases and 1 a local recurrence and metastasis. The survival of patients after radiotherapy alone was worse than that of patients after surgery with/without radiotherapy (p = 0.005). Pathological fractures (n 16) did not influence the prognosis.
authors.affiliation: Department of Orthopaedics, Westfälische Wilhelms-University, Münster, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Ozaki
authors.forename: A
authors.initials: A
authors.lastname: Hillmann
authors.forename: C
authors.initials: C
authors.lastname: Hoffmann
authors.forename: C
authors.initials: C
authors.lastname: Rübe
authors.forename: B
authors.initials: B
authors.lastname: Dockhorn-Dworniczak
authors.forename: S
authors.initials: S
authors.lastname: Blasius
authors.forename: J
authors.initials: J
authors.lastname: Dunst
authors.forename: J
authors.initials: J
authors.lastname: Treuner
authors.forename: H
authors.initials: H
authors.lastname: Jürgens
authors.forename: W
authors.initials: W
authors.lastname: Winkelmann
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D005266:Femoral Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D011878:Radiotherapy; D012512:Sarcoma, Ewing / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D013514:Surgical Procedures, Operative / Q000379:methods; D016896:Treatment Outcome