title: Plasma fatty acid levels in South African interethnic male high school pupils at different ultimate risks of coronary heart disease.
abstract: While coronary heart disease (CHD) is responsible for about a quarter of deaths in South African white, coloured and Indian populations, the rate is very low in the black population. Dietary risk factors for CHD include high intakes of saturated fatty acids and cholesterol, with low intakes of mono and polyunsaturated fatty acids. In a characterization study, plasma fatty acid profiles have been determined in seven groups of high school pupils aged 16-18 years, namely, white, rural black, urban black and middle-class and lower socio-economic class coloureds and Indians. Plasma fatty acids were measured by gas liquid chromatography in 20 subjects from each group. Contrary to expectation, urban and rural black pupils had the highest mean molar composition of saturated fatty acids, largely myristic (14:0) and palmitic (16:0) acids. Rural blacks and middle-class coloureds had the highest molar percentage composition of monounsaturated fatty acids, primarily oleic acid (18:1). Again unexpectedly, white, coloured and Indian groups had the highest level of polyunsaturated fatty acids, due entirely to linoleic acid (18:2). As the findings are unrelated to proneness to CHD mortality in the particular communities studied, plasma fatty acid levels are not predictive of the disease. Epidemiologically, there are many examples of lack of correlation in serum lipid levels and proneness to CHD.
authors.affiliation: Department of Haematology, School of Pathology, South African Institute for Medical Research, Johannesburg.
authors.forename: N
authors.initials: N
authors.lastname: Chetty
authors.forename: N H
authors.initials: NH
authors.lastname: Naran
authors.forename: A R
authors.initials: AR
authors.lastname: Walker
authors.forename: H C
authors.initials: HC
authors.lastname: Seftel
authors.forename: B I
authors.initials: BI
authors.lastname: Joffe
authors.forename: F J
authors.initials: FJ
authors.lastname: Raal
mesh_terms: D000293:Adolescent; D000328:Adult; D044383:Black People; D003327:Coronary Disease / Q000097:blood* / Q000453:epidemiology* / Q000208:ethnology; D005227:Fatty Acids / Q000097:blood*; D006801:Humans; D007194:India / Q000208:ethnology; D008297:Male; D012307:Risk Factors; D012424:Rural Population; D013019:South Africa / Q000453:epidemiology; D014505:Urban Population
chemical_list: D005227:Fatty Acids