title: [The pharmacokinetics of D-lactate, L-lactate and acetate in humans].
abstract: In this study, the pharmacokinetics of D-lactate, L-lactate and acetate were investigated in 36 adult surgical patients. After induction of general anaesthesia, the subjects received intravenous injection of either 5 mmoles of D-lactate and 5 mmoles of L-lactate simultaneously (Group DL), 10 mmoles of L-lactate (Group L), or 10 mmoles of acetate (Group A). Serial arterial blood samples were obtained before the injection, and 3, 5, 7, 9 and 11 minutes after the infusion of each preparation. Plasma concentrations of D-lactate, L-lactate and acetate were measured by high performance liquid chromatography, enzymatic analysis and spectrophotometry. The pharmacokinetic parameters; distribution volume (Vd) and half-life (t1/2) were calculated with a one-compartment model from the incremental plasma concentration decay curve after administration. In Group DL, there were no differences between D-lactate and L-lactate in Vd and t1/2. Also, between L-lactate in Group DL and that in Group L, there were no differences in Vd and t1/2. The Vd and T1/2 of acetate, however, were smaller than those of L-lactate in Group L. We conclude that the pharmacokinetics of D-lactate is similar to those of L-lactate, and that acetate may be metabolized more rapidly than L-lactate.
authors.affiliation: Department of Anesthesiology, Faculty of Medicine, Toyama Medical and Pharmaceutical University.
authors.forename: T
authors.initials: T
authors.lastname: Hamada
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Nakamaru
authors.forename: K
authors.initials: K
authors.lastname: Iwaki
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Koizumi
mesh_terms: D019342:Acetic Acid / Q000097:blood / Q000493:pharmacokinetics*; D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D005260:Female; D006207:Half-Life; D006801:Humans; D007552:Isotonic Solutions / Q000493:pharmacokinetics*; D019344:Lactic Acid / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D000077325:Ringer's Lactate; D013237:Stereoisomerism
chemical_list: D007552:Isotonic Solutions; D000077325:Ringer's Lactate; C028570:Ringer's acetate; D019344:Lactic Acid; D019342:Acetic Acid