Trace element composition and histological analysis of rat bones from the space shuttle.
The physiological and pharmacobiological changes associated with space flight are of greater concern. Exposure to a weightless environment has been shown to have numerous effects on body composition and organ functions. Alterations include decreases in muscle and liver mass, changes in bone structure and integrity, and changes in cardiovascular functions. Zero-gravity in particular has been reported to inhibit several physiological processes of bone formation, retard bone growth and impair the mechanical properties of bones. This report examines the effect of 14 days of spaceflight on the bone trace element compositions of rapidly growing rats. Marked changes of bone trace element contents were found in either weight-bearing bones or non-weight-bearing bones, depending on the metal species. Histological examination revealed an irregular thickening of the endosteal surface of the cortical bone (thoracic vertebrae) of the in-flight rat, whereas it was uniform in the ground control. We suggest that the microgravity environment causes several bone alternations, such as abnormal trace element compositions and defects in vertebral maturation.
Yamada
G
G
Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering, Kagoshima University, Japan. gen@apc.eng.kagoshima-u.ac.jp
Sugimura
K
K
Nakamura
S
S
Yamada
M O
MO
Tohno
Y
Y
Maruyama
I
I
Kitajima
I
I
Minami
T
T
D000818:Animals; D016723:Bone Remodeling; D001862:Bone Resorption; D001842:Bone and Bones / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D010012:Osteogenesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012272:Ribs / Q000378:metabolism / Q000473:pathology; D013026:Space Flight; D013131:Spine / Q000378:metabolism / Q000473:pathology; D013997:Time Factors; D014131:Trace Elements / Q000378:metabolism*; D014893:Weightlessness / Q000009:adverse effects*
D014131:Trace Elements