title: Etoposide and thiotepa followed by ABMT (autologous bone marrow transplantation) in children and young adults with high-grade gliomas.
abstract: The addition of conventional chemotherapy to irradiation has improved the outcome of children with malignant gliomas. The application of high-dose chemotherapy has been proposed as a possible way to increase the response rate and thus the survival in children with malignant brain tumours. High-dose etoposide (500 mg/m2/day x 3) and thiotepa (300 mg/m2/day x 3) followed by bone marrow transplantation were given to 22 patients (age range 4-20 years) with newly diagnosed or recurrent high-grade glioma. The response rate in the 14 assessable patients was 29% with one complete and three partial responses. 5 patients had stable disease, and 5 progressive disease. 2 patients died of treatment-related toxicity. Only 3 patients remain alive disease free 54, 60 and 65 months after high-dose therapy. For children with high-grade gliomas, survival using high-dose chemotherapy is no better than that reported with conventional treatments.
authors.affiliation: Paediatric Department, Centre Léon Bérard, Lyon, France.
authors.forename: E
authors.initials: E
authors.lastname: Bouffet
authors.forename: C
authors.initials: C
authors.lastname: Mottolese
authors.forename: A
authors.initials: A
authors.lastname: Jouvet
authors.forename: I
authors.initials: I
authors.lastname: Philip
authors.forename: D
authors.initials: D
authors.lastname: Frappaz
authors.forename: C
authors.initials: C
authors.lastname: Carrie
authors.forename: M
authors.initials: M
authors.lastname: Brunat-Mentigny
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D001932:Brain Neoplasms / Q000473:pathology / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D005910:Glioma / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D015996:Survival Rate; D013852:Thiotepa / Q000008:administration & dosage
chemical_list: D005047:Etoposide; D013852:Thiotepa