Renin-angiotensin system in the antihypertensive effect of isoteoline in spontaneously hypertensive rats.
1. The aim of the present study was to examine the effects of isoteoline (IST), a new tetrahydroaporphine derivative, on the blood pressure and some of the components of renin-angiotensin-aldosterone system (RAAS) in spontaneously hypertensive rats (SHR). 2. After long-term treatment (14 days, 3 times daily) in a dose of 1 mg/kg orally and intraperitoneally, IST induced a significant decrease of the systolic blood pressure (SBP) in SHR (from 192 +/- 2 to 155 +/- 5 mgHg). 3. At the same time, IST induced a significant decrease of the levels of plasma renin activity (PRA) and aldosterone (ALD) and manifested a trend to increase the sodium plasma level. 4. These results indicate that IST after chronic long-term treatment induced a marked antihypertensive effect and inhibited the components of RAAS in SHR. Apparently, the long-lasting antihypertensive effect of IST in SHR was mediated and realized in part by inhibition of the components of RAAS.
Markov
M
M
Department of Pharmacology, Faculty of Medicine, Higher Medical School, Sofia, Bulgaria.
Higashino
H
H
Suzuki
A
A
D000450:Aldosterone / Q000097:blood; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001060:Aporphines / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D066298:In Vitro Techniques; D051379:Mice; D051381:Rats; D011918:Rats, Inbred SHR; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects*
D000959:Antihypertensive Agents; D001060:Aporphines; D000450:Aldosterone; C044170:isoteolin; D012083:Renin