[The effect of difenin, valproate and phenobarbital on the development of an epileptiform seizure attack in Krushinskiĭ-Molodkina rats].
The anticonvulsant action of diphenin, sodium valproate, and pentobarbital was studied in Krushinskiĭ-Molodkina (KM) rats subjected to audiogenic seizures. The anticonvulsant effects of the drugs were different and dose-dependent. Valproate in a dose of 120 mg/kg completely eliminated the tonic phase of seizures. Given in a dose of 300 mg/kg it in 50% of cases prevented from the development of the initial seizure stage of motor excitation. The peculiarity of the pentobarbital action consisted in its ability to change the character of motor excitation during sound stimulation from the one-wave reaction for the two-wave.
Fedotova
I B
IB
Semiokhina
A F
AF
Fless
D A
DA
Arkhipova
G V
GV
D000161:Acoustic Stimulation; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004827:Epilepsy / Q000188:drug therapy* / Q000209:etiology; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D008297:Male; D010424:Pentobarbital / Q000627:therapeutic use*; D010672:Phenytoin / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000188:drug therapy* / Q000209:etiology; D014635:Valproic Acid / Q000627:therapeutic use*
D000927:Anticonvulsants; D006993:Hypnotics and Sedatives; D014635:Valproic Acid; D010672:Phenytoin; D010424:Pentobarbital
Vliianie difenina, val'proata i pentobarbitala na razvitie épileptiformnogo sudorozhnaogo pripadka u krys linii Krushinskogo--Molodkinoĭ.