Investigations on the protective action of Condonopsis pilosula (Dangshen) extract on experimentally-induced gastric ulcer in rats.
The action of Codonopsis pilosula extract in 5 animal models of gastric ulcer was investigated. It was found that the extract had higher efficacy on gastric ulcer induced by stress, acetic acid and sodium hydroxide and little significant effect on ulcers induced by pyloroligature and indomethacin. The C. pilosula extract was also capable of reducing gastric acid pepsin secretion. It is possible that inhibition of gastrointestinal movement and propulsion is one of the mechanisms underlying the antiulcer action of C. pilosula extract.
Wang
Z T
ZT
Department of Pharmacognosy, China Pharmaceutical University, Najing, China.
Du
Q
Q
Xu
G J
GJ
Wang
R J
RJ
Fu
D Z
DZ
Ng
T B
TB
D019342:Acetic Acid; D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004386:Duodenum / Q000187:drug effects / Q000502:physiology; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D005769:Gastrointestinal Motility / Q000187:drug effects; D007213:Indomethacin; D051379:Mice; D010434:Pepsin A / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D013312:Stress, Physiological
D000897:Anti-Ulcer Agents; D004365:Drugs, Chinese Herbal; D010434:Pepsin A; D019342:Acetic Acid; D007213:Indomethacin