Cytoplasmic antineutrophil cytoplasmic antibody-positive vasculitis associated with ulcerative colitis.
The case of a man with poorly controlled ulcerative colitis, who developed a cytoplasmic antineutrophil cytoplasmic antibody-positive systemic vasculitis, causing small bowel infarction is reported. Antineutrophil cytoplasmic antibodies occur in 50-70% of patients with ulcerative colitis, but are usually of the perinuclear or atypical pattern; the cytoplasmic pattern seen in this case is indicative of systemic vasculitis. A variety of vasculitic diseases have been reported as occurring rarely with ulcerative colitis, but this report is the first description of a cytoplasmic antineutrophil cytoplasmic antibody-positive vasculitis with this association.
Weir
A
A
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom.
Taylor-Robinson
S D
SD
Poole
S
S
Pignatelli
M
M
Walters
J F
JF
Calam
J
J
D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D003093:Colitis, Ulcerative / Q000150:complications / Q000276:immunology*; D003593:Cytoplasm / Q000276:immunology; D006801:Humans; D007238:Infarction / Q000209:etiology; D007421:Intestine, Small / Q000098:blood supply; D008297:Male; D017445:Skin Diseases, Vascular / Q000150:complications / Q000473:pathology; D014657:Vasculitis / Q000150:complications / Q000276:immunology* / Q000473:pathology; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000150:complications / Q000473:pathology
D019268:Antibodies, Antineutrophil Cytoplasmic