Macrophages infected with cytopathic bovine viral diarrhea virus release a factor(s) capable of priming uninfected macrophages for activation-induced apoptosis.
Bovine bone marrow-derived macrophages infected with the cytopathic biotype of bovine viral diarrhea virus released an antiviral activity into the supernatant which was tentatively characterized as type I interferon because of its physicochemical properties. Such supernatants primed both infected and uninfected macrophages for decreased nitric oxide production and apoptosis in response to lipopolysaccharide. This finding strongly suggests a role of this pathway in the pathogenesis of mucosal disease, a lethal form of infection with cytopathic bovine viral diarrhea virus in which the principal lesions are located in the oral cavity and the gastrointestinal tract, which are known to contain a high concentration of endotoxin.
Adler
B
B
Institute of Veterinary Virology, University of Bern, Switzerland.
Adler
H
H
Pfister
H
H
Jungi
T W
TW
Peterhans
E
E
D000818:Animals; D017209:Apoptosis; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000821:virology; D002417:Cattle; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral; D001908:Diarrhea Viruses, Bovine Viral / Q000302:isolation & purification / Q000502:physiology*; D007371:Interferon-gamma / Q000276:immunology; D008262:Macrophage Activation; D008264:Macrophages / Q000166:cytology / Q000276:immunology / Q000821:virology*; D009569:Nitric Oxide / Q000276:immunology; D015398:Signal Transduction
D009569:Nitric Oxide; D007371:Interferon-gamma