Molecular genetic analysis of synaptic plasticity, activity-dependent neural development, learning, and memory in the mammalian brain.
Recently, dozens of mutant mice generated with gene targeting or transgenic technologies have been shown to exhibit a distinct set of impairments in the brain and behavior. In this review, we discuss how studies of mutant mice have helped elucidate the mechanisms that underlie synaptic plasticity and the relationship of these synaptic mechanisms to the activity-dependent phase of neural development and learning and memory. We focus on the recent progress in the analysis of whisker-related pattern formation, elimination of climbing fibers, long-term potentiation, long-term depression, and various learning and memory tasks in mutant mice.
Chen
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Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.
Tonegawa
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D000818:Animals; D001921:Brain / Q000502:physiology; D007858:Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D051379:Mice; D008967:Molecular Biology; D009473:Neuronal Plasticity / Q000235:genetics*; D017729:Presynaptic Terminals / Q000502:physiology*