title: Blockade of afferent impulse activity disrupts on/off sublamination in the ferret lateral geniculate nucleus.
abstract: The ferret retinogeniculate projection is organized into on/off sublaminae within each eye-specific layer. The role of afferent activity in the formation of these sublaminae was examined. We report that when the activity of retinal ganglion cells is blocked with tetrodotoxin during postnatal weeks three and four, on/off sublamination is disrupted, supporting a role for afferent activity in the formation of this pattern.
authors.affiliation: Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA. karina@ai.mit.edu
authors.forename: K S
authors.initials: KS
authors.lastname: Cramer
authors.forename: M
authors.initials: M
authors.lastname: Sur
mesh_terms: D000344:Afferent Pathways / Q000187:drug effects; D000818:Animals; D001931:Brain Mapping / Q000379:methods*; D005123:Eye / Q000166:cytology / Q000187:drug effects*; D005289:Ferrets; D005829:Geniculate Bodies / Q000187:drug effects*; D008845:Microinjections; D012165:Retinal Ganglion Cells / Q000187:drug effects*; D013779:Tetrodotoxin / Q000494:pharmacology*; D014795:Visual Pathways / Q000187:drug effects*; D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
chemical_list: D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; D013779:Tetrodotoxin