Promotion of interleukin-2 activity as a strategy for 'rejuvenating' geriatric immune function.
The age-related decline in immune capacities is largely attributable to a decrease in the ability of activated T lymphocytes to achieve efficient clonal expansion. This in turn reflects a decrease in the expression of both interleukin-2 and its receptor. Nutritional/hormonal measures which up-regulate such expression may thus have a 'rejuvenatory' impact on geriatric immune function. Such measures may include: subtoxic selenium intakes, which increase the inducibility of interleukin-2 receptor; high-dose vitamin E and possibly chromium, which may counteract the down-regulatory effect of cAMP on interleukin-2 activity; as well as carotenoids and ascorbic acid. Restoring more youthful serum levels of the hormones DHEA and melatonin may also have a positive effect in this regard. In addition to their likely value for boosting geriatric immune defenses, these measures deserve evaluation as adjuvants to cancer immunotherapies and to drug treatments for HIV infection.
McCarty
M F
MF
Nutrition 21, San Diego, CA 92109, USA.
D000375:Aging / Q000276:immunology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002338:Carotenoids / Q000494:pharmacology; D002857:Chromium / Q000494:pharmacology; D017635:Clonal Anergy; D003687:Dehydroepiandrosterone / Q000494:pharmacology; D004032:Diet; D015658:HIV Infections / Q000628:therapy; D006801:Humans; D007167:Immunotherapy; D007376:Interleukin-2 / Q000096:biosynthesis / Q000502:physiology*; D008550:Melatonin / Q000494:pharmacology / Q000502:physiology; D008954:Models, Biological; D009369:Neoplasms / Q000628:therapy; D015375:Receptors, Interleukin-2 / Q000187:drug effects / Q000502:physiology*; D012643:Selenium / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D002857:Chromium; D014810:Vitamin E; D002338:Carotenoids; D003687:Dehydroepiandrosterone; D012643:Selenium; D008550:Melatonin