title: Nucleus raphe obscurus evokes 5-HT-1A receptor-mediated modulation of respiratory neurons.
abstract: We analysed in vivo the synaptic mechanisms underlying serotonin-mediated depression of expiratory neuronal discharges and phrenic nerve activity. We report that nucleus raphe obscurus stimulation not only abolishes phrenic nerve activity, but also hyperpolarizes the membrane potential, depresses periodic synaptic drive potentials and thus action potential discharges in caudal medullary expiratory neurons. These effects originate from pre- and post-synaptic inhibitory processes that involve 5-HT-1A receptor activation.
authors.affiliation: II. Physiology Institute, University of Göttingen, Germany. pl@facstaff.wisc.edu
authors.forename: P M
authors.initials: PM
authors.lastname: Lalley
authors.forename: R
authors.initials: R
authors.lastname: Benacka
authors.forename: A M
authors.initials: AM
authors.lastname: Bischoff
authors.forename: D W
authors.initials: DW
authors.lastname: Richter
mesh_terms: D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D004594:Electrophysiology; D005260:Female; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology*; D018408:Patch-Clamp Techniques; D010791:Phrenic Nerve / Q000187:drug effects / Q000502:physiology; D010879:Piperazines / Q000494:pharmacology; D011903:Raphe Nuclei / Q000187:drug effects / Q000502:physiology*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D015656:Respiratory Mechanics / Q000187:drug effects / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology
chemical_list: D010879:Piperazines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C058895:1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine