Effects of eicosanoids on parameters in isolated rat hepatocytes and isolated rat hepatocyte couplets: protective effects of eicosanoid receptor antagonists.
A number of eicosanoids caused plasma membrane blebbing in hepatocytes and this could be inhibited in a dose-dependent fashion by the receptor antagonists AH6809 and ICI 192605. The pattern of effectiveness of eicosanoids interfering with canalicular vacuole accumulation in hepatocyte couplets differed from that causing blebbing; the two most effective eicosanoids here were PGD2 and PGF2 alpha.
Hutchinson
S M
SM
School of Biochemistry, University of Birmingham, Edgbaston, UK.
Hammond
T G
TG
Coleman
R
R
Horton
A A
AA
D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D002478:Cells, Cultured; D002793:Cholic Acids / Q000378:metabolism; D015237:Dinoprost / Q000494:pharmacology; D015232:Dinoprostone / Q000494:pharmacology; D004146:Dioxanes / Q000494:pharmacology; D015777:Eicosanoids / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005452:Fluoresceins / Q000378:metabolism; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D015230:Prostaglandin D2 / Q000494:pharmacology; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology; D051381:Rats; D018055:Receptors, Eicosanoid / Q000037:antagonists & inhibitors*; D013928:Thromboxane A2 / Q000031:analogs & derivatives / Q000494:pharmacology; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014966:Xanthenes / Q000494:pharmacology; D044004:Xanthones
D002793:Cholic Acids; D004146:Dioxanes; D015777:Eicosanoids; D005452:Fluoresceins; D011448:Prostaglandin Antagonists; D011450:Prostaglandin Endoperoxides, Synthetic; D018055:Receptors, Eicosanoid; D014662:Vasoconstrictor Agents; D014966:Xanthenes; D044004:Xanthones; C072313:cholyl-lysylfluorescein; C057498:ICI 192605; C053876:6-isopropoxy-9-oxoxanthene-2-carboxylic acid; D013928:Thromboxane A2; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D015237:Dinoprost; D015232:Dinoprostone; D015230:Prostaglandin D2