title: Oral immunoglobulin treatment in Crohn's disease.
abstract: Two patients with severe Crohn's disease who failed to respond to traditional medical treatment were given immunoglobulin orally. We used the 6-h urinary recovery of mixture of polyethyleneglycols PEG 400 and 1000 (molecular weight range 282-1250 Da) to test the intestinal permeability. Both patients showed a similar permeability pattern with an increased leakage of large-sized PEGs before treatment and a lower urinary recovery of probes after treatment with immunoglobulin. This might indicate that the inflammatory process in Crohn's disease can be affected from the luminal side of the mucosa.
authors.affiliation: Department of Paediatrics, Norrköping Hospital, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Tjellström
authors.forename: L
authors.initials: L
authors.lastname: Stenhammar
authors.forename: K E
authors.initials: KE
authors.lastname: Magnusson
authors.forename: T
authors.initials: T
authors.lastname: Sandqvist
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D003424:Crohn Disease / Q000628:therapy*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage*; D011092:Polyethylene Glycols / Q000008:administration & dosage
chemical_list: D007136:Immunoglobulins; D011092:Polyethylene Glycols