title: Bone formers: osteophyte and enthesophyte formation are positively associated.
abstract: OBJECTIVE
  To test the hypothesis that enthesophyte formation and osteophyte growth are positively associated and to look for associations between bone formation at different sites on the skeleton so that a simple measure of bone formation could be derived.
  
  
  METHODS
  Visual examination of 337 adult skeletons. All common sites of either enthesophyte or osteophyte formation were inspected by a single observer who graded bone formation at these sites on a 0-3 scale. The total score for each feature was divided by the number of sites examined to derive an enthesophyte and an osteophyte score. Cronbach's alpha and principal components analysis were used to identify groupings.
  
  
  RESULTS
  Enthesophyte formation was associated with gender (M > F) and age. There was a positive correlation between enthesophytes and osteophytes (r = 0.65, 95% confidence interval, 0.58 to 0.71) which remained after correction for age and gender. Principal components analysis indicated four different groupings of enthesophyte formation. By choosing one site from each group a simple index of total skeletal bone formation could be derived.
  
  
  CONCLUSIONS
  Osteophytes and enthesophytes are associated, such that a proportion of the population can be classified as "bone formers". Enthesophyte groupings provide some clues to aetiopathogenesis. Bone formation should be investigated as a possible determinant of the heterogeneity of outcome and of treatment responses in common musculoskeletal disorders.
authors.affiliation: Department of Medicine, University of Bristol, Royal Infirmary, United Kingdom.
authors.forename: J
authors.initials: J
authors.lastname: Rogers
authors.forename: L
authors.initials: L
authors.lastname: Shepstone
authors.forename: P
authors.initials: P
authors.lastname: Dieppe
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D007596:Joints / Q000473:pathology*; D008023:Ligaments, Articular; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000473:pathology*; D010164:Paleopathology; D012680:Sensitivity and Specificity; D012737:Sex Factors; D013223:Statistics as Topic