Photorepair of ultraviolet radiation (UVR)-induced pyrimidine dimers in lens epithelial DNA of Monodelphis domestica.
The repair of UV radiation-induced pyrimidine dimers has been measured in lens epithelial DNA of the marsupial Monodelphis domestica using a pyrimidine dimer-specific endonuclease from Micrococcus luteus. Approximately 40% of the initially induced dimers were repaired during 90 min exposures to photoreactivating light. This capacity of the lens epithelium to photorepair pyrimidine dimers may provide a means with which to determine whether pyrimidine dimers in lens epithelial DNA are involved in UV radiation-induced pathologic changes of the lens.
Tafoya
G B
GB
Photomedicine Program, Institute for Basic and Applied Medical Research, Lovelace Institutes, Albuquerque, NM 87108, USA.
Gale
J M
JM
Ley
R D
RD
D000818:Animals; D004260:DNA Repair / Q000528:radiation effects; D007908:Lens, Crystalline / Q000378:metabolism / Q000528:radiation effects*; D009893:Opossums; D010777:Photochemistry; D011740:Pyrimidine Dimers / Q000378:metabolism*; D014466:Ultraviolet Rays
D011740:Pyrimidine Dimers