title: [Elimination of virulence plasmids of Yersinia pseudotuberculosis as affected by fluoroquinolones].
abstract: Pefloxacin, ciprofloxacin and norfloxacin were shown to induce elimination of the virulence plasmids in the strains of Y. pseudotuberculosis. Pefloxacin had a more pronounced eliminating effect than ciprofloxacin and norfloxacin. The elimination of the virulence plasmids with the molecular weight of 40-50 MD in the strains of Y. pseudotuberculosis was more frequent at the subinhibitory concentrations of the fluoroquinolones or at 1/4 of the fluoroquinolone MIC., At 1/8 of the MIC it was rarer. The virulence plasmid elimination in the strains was observed in spite of their serovar but was more frequent in the serovar 1B strains.
authors.forename: E A
authors.initials: EA
authors.lastname: Zaĭtseva
authors.forename: F N
authors.initials: FN
authors.lastname: Shubin
authors.forename: N N
authors.initials: NN
authors.lastname: Besednova
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008970:Molecular Weight; D009643:Norfloxacin / Q000494:pharmacology; D015366:Pefloxacin / Q000494:pharmacology; D010957:Plasmids / Q000187:drug effects* / Q000235:genetics; D014774:Virulence; D015011:Yersinia pseudotuberculosis / Q000235:genetics* / Q000472:pathogenicity
chemical_list: D000890:Anti-Infective Agents; D015366:Pefloxacin; D002939:Ciprofloxacin; D009643:Norfloxacin
vernacular_title: Eliminatsiia plazmid virulentnosti Yersinia pseudotuberculosis pod vliianiem ftorkhinolonov.