The role of endogenous nitric oxide synthesis in contractility of term or preterm human myometrium.
OBJECTIVE
To assess in vitro the role of endogenous myometrial nitric oxide synthesis on human myometrial contraction.


METHODS
Strips of myometrium were mounted in a standard organ bath for assessment of isometric contraction and the response to modulators of nitric oxide synthesis determined.


METHODS
A teaching hospital research laboratory.


METHODS
Women undergoing elective nonlabour caesarean section under regional anaesthesia: 54 at term and seven preterm.


RESULTS
Neither addition of L-arginine, the substrate for nitric oxide synthase, nor of an inhibitor of nitric oxide synthase led to any specific change in spontaneous myometrial contraction.


CONCLUSIONS
Endogenous nitric oxide production does not play an important role in the control of human term of preterm nonlabouring uterine smooth muscle contractility.
Jones
G D
GD
Division of Obstetrics and Gynaecology, UMDS, St Thomas' Hospital, London, UK.
Poston
L
L
D001120:Arginine / Q000494:pharmacology; D005260:Female; D006801:Humans; D009119:Muscle Contraction / Q000187:drug effects; D009215:Myometrium / Q000201:enzymology*; D016202:N-Methylaspartate / Q000494:pharmacology; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000096:biosynthesis*; D019001:Nitric Oxide Synthase / Q000494:pharmacology; D007752:Obstetric Labor, Premature; D011247:Pregnancy
D009569:Nitric Oxide; D016202:N-Methylaspartate; D001120:Arginine; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester