title: Synthesis of some new quinazolines and quinoxalines of potential antiinflammatory activity.
abstract: A number of quinazoline derivatives containing basic amine substituents at position 4, as well as new derivatives of triazolo[4,3-alpha]quinoxalines carrying basic amine or carboxylic acid moieties have been synthesized. A tetracyclic imidazotriazoloquinoxaline compound is also reported. Two of the new products (2b and 7b) exhibited good antiinflammatory activity in rats, although inferior to that of indomethacin.
authors.affiliation: Dept. of Medicinal Chemistry, Faculty of pharmacy, University of Mansoura, Egypt.
authors.forename: E R
authors.initials: ER
authors.lastname: el-Bendary
authors.forename: M B
authors.initials: MB
authors.lastname: el-Ashmawy
authors.forename: A M
authors.initials: AM
authors.lastname: Barghash
authors.forename: I A
authors.initials: IA
authors.lastname: Shehata
authors.forename: M M
authors.initials: MM
authors.lastname: el-Kerdawy
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011799:Quinazolines; D011810:Quinoxalines; D002351:Carrageenan