A comparison of amino acid sequences of hepatitis B virus S gene in 46 children presenting various clinical features for immunoprophylaxis.
We compared amino acid sequences of hepatitis B virus (HBV) S protein deduced from analyzed DNA sequence in 46 children who received immunoprophylaxis to prevent mother-to-child transmission of HBV. They were classified into 6 groups by their clinical features. The antibody escape mutants were found in 8 cases among 46 cases. We studied the difference in clinical features in these cases and speculated that 126 Ser or 140 Ser-strain may have a different behavior in relation to antibody to hepatitis B surface antigen from 126 Asn or 145 Arg-strain.
Miyake
Y
Y
Department of Pediatrics, Nagoya City University Medical School, Japan.
Oda
T
T
Li
R
R
Sugiyama
K
K
D000595:Amino Acid Sequence; D005260:Female; D005814:Genes, Viral; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006511:Hepatitis B Antigens / Q000032:analysis*; D006513:Hepatitis B e Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D007167:Immunotherapy; D007223:Infant; D007231:Infant, Newborn; D008969:Molecular Sequence Data; D009154:Mutation; D011247:Pregnancy; D011315:Preventive Medicine / Q000379:methods*
D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens; D006513:Hepatitis B e Antigens