title: [Drug-induced pneumonitis associated PABRON-GOLD].
abstract: A 75-year-old man had for many years taken the commercially sold medicine PABRON-S whenever he caught a cold. He caught a cold and took the drug six days before admission. When PABRON-S was not available, he took PABRON-GOLD and experienced dyspnea the next day. A roentgenogram at another hospital revealed bilateral diffuse lung shadows. He was referred to our hospital. A thoracic CT scan showed bilateral interstitial shadows. Bronchoalveolar lavage fluid contained inflammatory cells including neutrophils and lymphocytes. Examination of a transbronchial lung biopsy specimen showed infiltration of mononuclear cells into the thick alveolar wall and interstitum. A drug lymphocyte stimulation test with PABRON-GOLD was positive. Based on these findings, we believe that this patient had drug-induced pneumonitis caused by PABRON-GOLD. He was treated with a steroid hormone and his symptoms resolved immediately, the abnormal roentgenographic shadows remained longer.
authors.affiliation: Second Department of Internal Medicine, Koseiren Takaoka Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nomura
authors.forename: M
authors.initials: M
authors.lastname: Fujimura
authors.forename: T
authors.initials: T
authors.lastname: Matsuda
authors.forename: M
authors.initials: M
authors.lastname: Kitagawa
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D000368:Aged; D003061:Codeine / Q000009:adverse effects / Q000031:analogs & derivatives*; D004338:Drug Combinations; D006801:Humans; D008297:Male; D009113:Muramidase / Q000009:adverse effects*; D004366:Nonprescription Drugs / Q000009:adverse effects; D011014:Pneumonia / Q000139:chemically induced*
chemical_list: D004338:Drug Combinations; D004366:Nonprescription Drugs; C105883:PABRON-GOLD; D000082:Acetaminophen; D009113:Muramidase; D003061:Codeine