Oxygen delivery as a factor in the development of fatal postoperative complications after oesophagectomy.
BACKGROUND
This study was designed to assess the impact of oxygen transport variables on outcome in 115 patients undergoing elective surgery for oesophageal carcinoma.


METHODS
Haemodynamic parameters were determined using a Swan-Ganz catheter in all patients on the day before operation, 6 h after operation, and daily for the first 4 days after operation.


RESULTS
Oxygen delivery and consumption at 6 h were significantly higher in survivors than in non-survivors. However, oxygen delivery and consumption in both groups did not differ significantly after postoperative day 1. Of 17 patients with oxygen delivery levels lower than 445 ml min-1 m-2 at 6 h, eight died in hospital. Oxygen delivery in patients who developed either an anastomotic leak or severe pneumonia was significantly lower 6 h after surgery. Lower levels of oxygen delivery preceded postoperative complications.


CONCLUSIONS
Oxygen delivery 6 h after oesophagectomy correlates with postoperative complications and may be a determinant of hospital mortality.
Kusano
C
C
First Department of Surgery, Kagoshima University, School of Medicine, Japan.
Baba
M
M
Takao
S
S
Sane
S
S
Shimada
M
M
Shirao
K
K
Natsugoe
S
S
Fukumoto
T
T
Aikou
T
T
D000368:Aged; D001692:Biological Transport; D001794:Blood Pressure; D004938:Esophageal Neoplasms / Q000503:physiopathology / Q000601:surgery*; D016629:Esophagectomy / Q000379:methods* / Q000401:mortality; D005260:Female; D005541:Forced Expiratory Volume; D006439:Hemodynamics; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000493:pharmacokinetics*; D010101:Oxygen Consumption; D013318:Stroke Volume; D014655:Vascular Resistance; D014797:Vital Capacity
D010100:Oxygen