Systemic immediate-type reactions to gelatin included in Japanese encephalitis vaccines.
Three children had systemic immediate-type reactions to Japanese encephalitis (JE) vaccine which contains gelatin as a stabilizer. We found that all the children had anti-gelatin IgE in their sera. Further, two of the three also had experienced systemic allergic reactions to gelatin-containing foods before the vaccination. We assume that the systemic allergic reactions to JE vaccines might be caused by gelatin in the JE vaccine.
Sakaguchi
M
M
Department of Epidemiology, National Institute of Health, Tokyo, Japan.
Yoshida
M
M
Kuroda
W
W
Harayama
O
O
Matsunaga
Y
Y
Inouye
S
S
D000707:Anaphylaxis / Q000276:immunology; D002675:Child, Preschool; D004664:Encephalitis Virus, Japanese / Q000276:immunology*; D005260:Female; D005780:Gelatin / Q000009:adverse effects / Q000276:immunology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000209:etiology*; D008297:Male; D014765:Viral Vaccines / Q000009:adverse effects* / Q000276:immunology
D014765:Viral Vaccines; D005780:Gelatin