[The mechanisms of Epstein-Barr virus activation in B cells].
Epstein-Barr virus (EBV) infects B lymphocytes, resulting in immortalization of the cells. We have been studying the mechanisms of EBV activation in the Akata cells. Crosslinking of mIg of B cells led to rapid tyrosine phosphorylation which is an essential event in EBV activation. We found that EBV activation was induced with calcium ionophore, which was synergized by protein kinase C agonists. The expression of ZEBRA, BZLF1 immediate early gene product is sufficient to trigger the activation for the virus lytic cycle. We analyzed the regulation of BZLF1 promoter and defined the anti-Ig responsive elements. We found the phosphorylation for serine residues of ZEBRA in Akata cells.
Sairenji
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Department of Biosignaling, School of Life Science, Faculty of Medicine, Tottori University.
D001402:B-Lymphocytes / Q000502:physiology / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000254:growth & development*; D015398:Signal Transduction; D014775:Virus Activation / Q000502:physiology*