Cervical gangliectomy does not affect in vitro tryptophan hydroxylase activity in rat brain base arteries.
The presence of a serotonergic innervation in rat cerebral arteries of peripheral origin was explored. Superior cervical ganglia removal did not change tryptophan hydroxylase activity measured in cell-free extracts of brain base vessels. A low enzyme activity was detected in the ganglia. These results suggest that rat cerebral arteries do not receive a serotonergic innervation from the superior cervical ganglia.
Moreno
M J
MJ
Departamento de Fisiología, Facultad de Medicina, Universidad Autonóma de Madrid, Spain.
López de Pablo
A L
AL
Marco
E J
EJ
D000818:Animals; D002536:Cerebral Arteries / Q000201:enzymology* / Q000294:innervation; D015171:Ganglionectomy; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism / Q000502:physiology; D017783:Superior Cervical Ganglion / Q000201:enzymology / Q000502:physiology; D013562:Sympathectomy; D014365:Tryptophan Hydroxylase / Q000378:metabolism*
D012701:Serotonin; D014365:Tryptophan Hydroxylase; D009638:Norepinephrine