The mapping and visual ordering of the human syndecan-1 and N-myc genes near the telomeric region of chromosome 2p.
The chromosomal locations of the human and mouse syndecan genes have been shown to associate with the corresponding locations of members of the myc gene family, proto-oncogenes that code for transcription factors. Here, we demonstrate the precise localization and order of the human syndecan-1 and N-myc genes using fluorescence in situ hybridization techniques that provide different levels of resolution. By visualizing the actual centromere-telomere orientation of these two genes, the human syndecan-1 gene is localized to 2p23-24, just centromeric to the N-myc gene at 2p24.1.
Kaukonen
J
J
Department of Clinical Medicine, University of Helsinki, Finland.
Alanen-Kurki
L
L
Jalkanen
M
M
Palotie
A
A
D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D016259:Genes, myc; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008562:Membrane Glycoproteins / Q000235:genetics*; D011509:Proteoglycans / Q000235:genetics*; D013194:Staining and Labeling; D053668:Syndecan-1; D053667:Syndecans; D016615:Telomere
D008562:Membrane Glycoproteins; D011509:Proteoglycans; C508241:SDC1 protein, human; C508242:Sdc1 protein, mouse; D053668:Syndecan-1; D053667:Syndecans