title: Life-threatening anaemia caused by B19 parvovirus infection in a non-immunocompromised patient.
abstract: A 21-year-old Surinam boy suffering from a combined heterozygous sickle-cell beta-thalassaemia presented with an extreme anaemia (haemoglobin concentration 0.7 mmol/l) and severe haemolysis without signs of increased erythropoiesis. An acute B19 parvovirus infection was diagnosed by a transient increase of IgM anti-B19 parvovirus titres and a positive polymerase chain reaction for B19 parvovirus. The patient recovered spontaneously after a short period of supportive care with red cell transfusions and mechanical ventilation.
authors.affiliation: Department of Haematology, University Hospital Utrecht, Netherlands.
authors.forename: D H
authors.initials: DH
authors.lastname: Biesma
authors.forename: H K
authors.initials: HK
authors.lastname: Nieuwenhuis
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000175:diagnosis / Q000821:virology*; D000755:Anemia, Sickle Cell / Q000150:complications*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D010322:Parvoviridae Infections / Q000150:complications* / Q000628:therapy; D016732:Parvovirus B19, Human; D017086:beta-Thalassemia / Q000150:complications*
chemical_list: D007075:Immunoglobulin M