title: [Clinical, phenotypic and genotypic aspects of nasal T-cell lymphoma and its causal association with Epstein-Barr virus].
abstract: The authors reviewed the clinical, phenotypic, genotypic, and Epstein-Barr virus (EBV)-findings of 18 patients with nasal T-cell lymphoma(NTL). The clinical features were characterized as prolonged fever, widespread dissemination into distant sites, and poor prognosis with median survival of only 6 months. EBV-encoded small nuclear early region(EBER) transcripts were identified in 16 of 18 patients. Monoclonal EBV genome, EBV-encoded nuclear antigen(EBNA)-1, and latent membrane protein(LMP)-1 were also detected in all EBER-positive cases tested. All EBV-positive NTL showed coexpression of natural killer(NK) cell phenotype CD56 and CD2. Of 9 EBV-positive NTL, seven cases expressed T-cell receptor (TCR)-delta chain with rearranged beta-, gamma- and/or delta- genes. These data suggest that some cases of EBV-positive NTL may be derived from the lineage of NK-like T-cells or gamma delta T-cells, and that EBV may play a role in the lymphomagenesis.
authors.affiliation: Department of Otolaryngology, School of Medicine, Sapporo Medical University.
authors.forename: Y
authors.initials: Y
authors.lastname: Harabuchi
authors.forename: S
authors.initials: S
authors.lastname: Imai
authors.forename: A
authors.initials: A
authors.lastname: Kataura
authors.forename: T
authors.initials: T
authors.lastname: Osato
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005838:Genotype; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D016399:Lymphoma, T-Cell / Q000235:genetics / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000235:genetics / Q000821:virology*; D010641:Phenotype