title: Alpha-brain spectrin mRNA belongs to the population of intradendritically transported mRNAs.
abstract: Brain spectrin is a cytoskeletal protein involved in neuronal polarization and differentiation. We have studied the intraneuronal expression of non-erythroid (NE) alpha-spectrin mRNA in the rat brain during the development of the CA3 pyramidal cells, and compared it with alpha-tubulin mRNA expression. In contrast to alpha-tubulin expression, which remains located in the neuronal somata, NE alpha-spectrin mRNA was present in the dendritic compartment during the first 2 weeks of life. NE alpha-Brain spectrin mRNA transport into the dendrites coincides with critical development events, including dendritic arborization, growth and synaptogenesis, and could be dependent on the appearance of synaptic activity at the mossy fibre/CA3 synapse.
authors.affiliation: INSERM U29, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Gelot
authors.forename: J
authors.initials: J
authors.lastname: Moreau
authors.forename: Y
authors.initials: Y
authors.lastname: Ben Ari
authors.forename: H
authors.initials: H
authors.lastname: Pollard
mesh_terms: D000818:Animals; D001345:Autoradiography; D001692:Biological Transport / Q000502:physiology; D001923:Brain Chemistry / Q000502:physiology*; D003712:Dendrites / Q000378:metabolism*; D017403:In Situ Hybridization; D008297:Male; D015345:Oligonucleotide Probes; D017966:Pyramidal Cells / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013049:Spectrin / Q000096:biosynthesis*; D013569:Synapses / Q000378:metabolism / Q000502:physiology; D014404:Tubulin / Q000096:biosynthesis
chemical_list: D015345:Oligonucleotide Probes; D012333:RNA, Messenger; D014404:Tubulin; D013049:Spectrin