title: [The role of adenosine in "ischemic preconditioning"].
abstract: Repeated short coronary occlusions trigger probably more than one pathway leading to increased tolerance toward ischemia. Adenosine plays probably a very important but not an exclusive role. It may act via opening of A1-receptor-operated K(+)-channels that lead to hyperpolarization of the cell, and it has antiadrenergic actions. A proposed action of adenosine via protein kinase C is not confirmed. Trophic factors are expressed during short periods of ischemia and contribute to survival, probably via inhibition of apoptosis.
authors.affiliation: Max-Planck-Institut, Abteilung für experimentelle Kardiologie, Bad Nauheim.
authors.forename: W
authors.initials: W
authors.lastname: Schaper
authors.forename: A
authors.initials: A
authors.lastname: Vogt
authors.forename: P
authors.initials: P
authors.lastname: Htun
mesh_terms: D000241:Adenosine / Q000502:physiology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D004562:Electrocardiography; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D015221:Potassium Channels / Q000502:physiology; D011493:Protein Kinase C / Q000502:physiology; D018047:Receptors, Purinergic P1 / Q000502:physiology
chemical_list: D015221:Potassium Channels; D018047:Receptors, Purinergic P1; D011493:Protein Kinase C; D000241:Adenosine
vernacular_title: Die Rolle von Adenosin bei "ischemic preconditioning".