[Optimization of the diagnosis and treatment of anemias under exposure to aromatic-type organic solvents].
171 iron-deficient painters and 20 subjects with chronic intoxication with aromatic hydrocarbons were studied in a large aircraft construction factory. After correlative analysis of iron metabolism, ferritin, erythrocytes, diameter and perimeter of reticulocytes, length of service three types of iron-deficiency were identified: typical, with evident toxicity, with a high risk of toxic damage. An important role of lipid peroxidation activity and toxic erythrocyto-membranopathy for pathomorphosis of iron deficiency anemia and progress of toxic anemia is demonstrated. A differential approach to treatment of different anemia variants was used. The treatment included membranoprotectors (alpha-tocopherol, essential, lypostabil) and unspecific detoxication (SUMS-enterosorbent, unitiol).
Shpagina
L A
LA
Loseva
M I
MI
Sukharevskaia
T M
TM
Sharapov
V I
VI
Sazonova
O V
OV
Tret'iakov
S V
SV
D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D000401:Aircraft; D000740:Anemia / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis / Q000628:therapy; D002908:Chronic Disease; D003131:Combined Modality Therapy; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009784:Occupational Diseases / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D010150:Paint / Q000009:adverse effects; D012997:Solvents / Q000009:adverse effects*
D000395:Air Pollutants, Occupational; D012997:Solvents
Optimizatsiia diagnostiki i lecheniia anemiĭ v usloviiakh vozdeĭstviia organicheskikh rastvoriteleĭ aromaticheskogo riada.