Baroreceptor function is restored by antihypertensive therapy through lowering of blood pressure in adult SHR.
1. We investigated the effects of antihypertensive treatment (8 weeks) with four different agents (trichlormethiazide, atenolol, nicardipine and enalapril) on baroreceptor function in 28 week old spontaneously hypertensive rats (SHR) to measure aortic depressor nerve (ADN) activity. 2. Threshold pressure (Pth) of ADN activity was elevated and the gain sensitivity of the pressure-activity curve, as determined by the maximum gain (Gmax) of a logistic function curve, was depressed in untreated SHR compared to those in untreated Wistar-Kyoto (WKY) rats. 3. Treatment with the four agents similarly reduced blood pressure in SHR. Each of the four agents induced a decrease in Pth and an increase in Gmax to a similar extent in SHR. 4. These findings suggest that antihypertensive therapy in chronic hypertension augments baroreceptor function through the lowering of blood pressure but not through specific pharmacological actions.
Ichikawa
M
M
Department of Internal Medicine, Keio University, School of Medicine, Tokyo, Japan.
Suzuki
H
H
Kumagai
K
K
Ryuzaki
M
M
Kumagai
H
H
Nishizawa
M
M
Saruta
T
T
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001011:Aorta / Q000294:innervation / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D003714:Denervation; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology*; D011311:Pressoreceptors / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D000959:Antihypertensive Agents