Inhibition of brain tubulin-guanosine 5'-triphosphate interactions by mercury: similarity to observations in Alzheimer's diseased brain.
Pendergrass
J C
JC
College of Pharmacy, Division of Medicinal Chemistry and Pharmaceutics, University of Kentucky Medical Center, Lexington 40536-0082, USA.
Haley
B E
BE
D000280:Administration, Inhalation; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D002614:Chelating Agents / Q000737:chemistry / Q000494:pharmacology; D004492:Edetic Acid / Q000737:chemistry / Q000494:pharmacology; D004533:Egtazic Acid / Q000737:chemistry / Q000494:pharmacology; D018698:Glutamic Acid / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D006160:Guanosine Triphosphate / Q000378:metabolism*; D006801:Humans; D007553:Isotope Labeling; D008628:Mercury / Q000378:metabolism / Q000633:toxicity*; D008870:Microtubules / Q000187:drug effects / Q000378:metabolism; D009711:Nucleotides / Q000737:chemistry / Q000378:metabolism; D051381:Rats; D014404:Tubulin / Q000187:drug effects / Q000378:metabolism*
D002614:Chelating Agents; D009711:Nucleotides; D014404:Tubulin; D018698:Glutamic Acid; D004533:Egtazic Acid; D006160:Guanosine Triphosphate; D004492:Edetic Acid; D008628:Mercury