Sudomotor function in sympathetic reflex dystrophy.
Sudomotor functions were studied in 27 patients suffering from reflex sympathetic dystrophy (RSD) according to the criteria established by Bonica (18 women, 9 men; mean age 50 +/- 12.3 years; median duration of disease 8 weeks, range 2-468 weeks). To measure local sweating rates, two small chambers (5 cm2) were affixed to corresponding areas of hairy skin on the affected and unaffected limbs. Dry nitrogen gas was passed through the chambers (270 ml/min) and evaporation was recorded at both devices with hygrometers. Thermoregulatory sweating (TST) was induced by raising body temperature (intake of 0.5 1 hot tea and infra-red irradiation). Local sweating was also induced through an axon reflex (QSART) by transcutaneous iontophoretic application of carbachol (5 min, 1 mA). In addition, skin temperature was measured on the affected and unaffected side by infra-red thermography. Mean skin temperature was significantly higher on the affected side (P < 0.003). In spite of the temperature differences, there was no difference in basal sweating on the affected and unaffected side. However, both methods of sudomotor stimulation lead to significantly greater sweating responses on the affected compared to the unaffected side (TST: P < 0.05, QSART: P < 0.004). Latency to onset of sweating was significantly shorter on the affected side under both test conditions (P < 0.04 and P < 0.003, respectively). Sweat responses were not correlated to absolute skin temperature but were probably related to the increased blood flow on the affected side. Our findings imply a differential disturbance of vasomotor and sudomotor mechanisms in affected skin. Whereas vasoconstrictor activity is apparently lowered, sudomotor output is either unaltered or may even be enhanced.
Birklein
F
F
Neurologische Klinik, Friedrich-Alexander-Universität Erlangen, Germany.
Sittl
R
R
Spitzer
A
A
Claus
D
D
Neundörfer
B
B
Handwerker
H O
HO
D001369:Axons / Q000502:physiology; D001833:Body Temperature Regulation / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007478:Iontophoresis; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000502:physiology; D012018:Reflex / Q000502:physiology; D012019:Reflex Sympathetic Dystrophy / Q000503:physiopathology*; D012881:Skin Temperature / Q000502:physiology; D013545:Sweat Glands / Q000294:innervation / Q000503:physiopathology*; D013546:Sweating / Q000502:physiology