[The nootropic agent vinpocetine blocks the delayed rectifier potassium channel more strongly than the high-conductance calcium channel].
In isolated neurons of Helix snail high-threshold Ca(2+)- and K(+)-currents were recorded using two-microelectrode voltage clamp technique. Extracellular application of nootropic drug vinpocetine rapidly and reversibly blocked both types of current. Vinpocetine effects were dose-dependent and voltage-independent. The maximal effect of Ca(2+)-current blockade was 27% during application of vinpocetine in the concentration of 600 mcM. The maximal blockade of K(+)-current was 75% when the drug was applied in the concentration of 30 mcM. Results suggest that K(+)-channels are more probable targets for vinpocetine than Ca(2+)-channels.
Bukanova
Iu V
IuV
Solntseva
E I
EI
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects* / Q000502:physiology; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006372:Helix, Snails; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D018697:Nootropic Agents / Q000494:pharmacology*; D018408:Patch-Clamp Techniques; D026902:Potassium Channel Blockers; D015221:Potassium Channels / Q000187:drug effects* / Q000502:physiology; D014748:Vinca Alkaloids / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D018697:Nootropic Agents; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D014748:Vinca Alkaloids; C013983:vinpocetine
Nootrop vinotsetin blokiruet kalievyĭ tok zaderzhannogo vypriamleniia sil'nee, chem vysokoporogovyĭ kal'tsievyĭ tok.