Urinary polyamine evaluation for effective diagnosis of various cancers.
With a newly modified analytical method, the concentrations of free and acetylated urinary polyamines were simultaneously determined in a control group (32 cases) and patients with various types of cancers (104 cases, 20 males and 84 females) by gas chromatography-nitrogen-phosphorus detection. Significant concentration differences between normal subjects and various cancer patients were found. The various types of cancers (advanced gastric carcinoma, ovarian cancer, acute myelocyte leukemia, non-Hodgkin's lymphoma) gave unique patterns of urinary polyamine profile as well as significant differences of concentration. To indirectly evaluate the possible involvement of enzymes, precursor-to-product concentration ratios were compared between controls and patients with various types of cancers.
Suh
J W
JW
Doping Control Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.
Lee
S H
SH
Chung
B C
BC
Park
J
J
D000328:Adult; D002277:Carcinoma / Q000175:diagnosis / Q000652:urine; D002849:Chromatography, Gas / Q000379:methods; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000652:urine; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000652:urine; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis / Q000652:urine*; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000652:urine; D011073:Polyamines / Q000652:urine*; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000652:urine
D011073:Polyamines